|Reference : Fetal nuchal translucency thickness in different cut-off points for aneuploidy screening...|
|Scientific journals : Article|
|Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)|
|Fetal nuchal translucency thickness in different cut-off points for aneuploidy screening in the south of Vietnam|
|To, Hong [Université de Liège - ULg > > > Doct. sc. médicales (Bologne)]|
|Schaaps, Jean-Pierre [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]|
|Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]|
|Journal of Obstetrics and Gynaecology Research|
|Yes (verified by ORBi)|
|[en] Nuchal translucency ; Aneuploidy ; First trimester ; cut-off point ; fetal nuchal translucency thickness; ; Trisomy 21|
|[en] Aims: The purpose of this study was to define the most suitable cut-off point for fetal nuchal translucency thickness in a screening program for aneuploidy and trisomy 21 in the south of Vietnam.
<br />Material & Methods: Two thousand and five hundred cases of singleton pregnancies were followed prospectively from the first trimester to the delivery. The rate of aneuploidy was calculated by seeking a relationship to increased fetal nuchal translucency thickness then calculating the sensitivity and specificity of different cut-off points in thickness measurement to find the most suitable point for screening.
<br />Results: The prevalence of fetal abnormality was 1.5% (95% CI 1.1–2.1), and 1.2% (95% CI 0.8–1.7) of aneuploidy cases found and the commonest was trisomy 21. A cut-off point at 2.4 mm showed the highest level of sensitivity and specificity for the detection of aneuploidy (65.5 and 95.7%) and trisomy 21 (75.0 and 95.1%), with a false-positive rate of 4.3 and 4.9%, respectively.
<br />Conclusion: Using a cut-off point of nuchal translucency at 2.4 mm has potential for aneuploidy and trisomy 21 screening in the south of Vietnam.
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