Working memory; Schizophrenia; Cognitive rehabilitation; everyday activities; Updating; Mémoire de travail; Schizophrénie; Remédiation cognitive; Activités de la vie quotidienne; Mise à jour
Abstract :
[en] Working memory problems have been identified as a core cognitive deficit in schizophrenia. In this paper, we present the results of a cognitive rehabilitation programme (Duval & Coyette, 2005) administered to a schizophrenia patient, and specifically designed to improve the updating sub-component of working memory. The original feature of this programme was that it involved two types of updating exercises: cognitive and ecological. The purpose was to enable the patient to acquire cognitive strategies that alleviate the mental load of the central executive and to transfer them to daily life. The specificity and efficacy of the programme were assessed with multiple (cognitive, ecological and non-target) baseline measurements. In addition, several questionnaires were administered to assess the effect of the programme on subjective cognitive complaints affecting daily life, psychiatric symptoms and self-esteem. The results demonstrated the efficacy of the rehabilitation programme on the updating function and the generalisation of these beneficial effects to daily life. A significant decrease in both subjective cognitive complaints and psychiatric symptoms was also observed. However, the patient's self-esteem did not improve.
Disciplines :
Theoretical & cognitive psychology
Author, co-author :
Levaux, Marie-Noëlle ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Vezzaro, J.
Laroi, Frank ; Université de Liège - ULiège > Département des sciences cognitives > Psychologie clinique cognitive et comportementale
Offerlin-Meyer, I.
Danion, J-M
Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Language :
English
Title :
Cognitive rehabilitation of the updating sub-component of working memory in schizophrenia: a case study.
Publication date :
2009
Journal title :
Neuropsychological Rehabilitation
ISSN :
0960-2011
eISSN :
1464-0694
Publisher :
Lawrence Erlbaum Associates, Inc., Hove, United Kingdom
Alptekin, K., Akvardar, Y., Akdede, B. B. K., Dumlu, K., Isik, D., Pirinçci, F. et al. (2005). Is quality of life associated with cognitive impairment in schizophrenia? Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29, 239-244.
American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders, (4th ed.). Washington, DC: American Psychiatric Association.
Baddeley, A. D. (1986). Working Memory. Oxford: Clarendon Press.
Baddeley, A. D. (1992). Is working memory working? Quarterly Journal of Experimental Psychology, 44A, 1-31.
Baddeley, A. D. (2000). The episodic buffer: A new component of working memory? Trends in Cognitive Sciences, 4, 417-423.
Baddeley, A. D., & Wilson, B. A. (2002). Prose recall and amnesia: Implications for the structure of working memory. Neuropsychologia, 40, 1737-1743.
Bagner, D. M., Melinder, M. R. D., & Barch, D. M. (2003). Language comprehension and working memory language comprehension and working memory deficits in patients with schizophrenia. Schizophrenia Research, 60, 299-309.
Barch, D. M., Carter, C. S., Braver, T. S., Sabb, F. W., MacDonald III, A., Noll, D. C. et al. (2001). Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Archives of General Psychiatry, 58, 280-288.
Belleville, S., Rouleau, N., & Caza, N. (1988). Effect of normal aging on the manipulation of information in working memory. Memory and Cognition, 26, 572-583.
Callicott, J. H., Bertolino, A., Mattay, V. S., Langheim, F. J. P., Dyun, J., Coppola, R. et al. (2000). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex, 10, 1078-1092.
Carter, C. S., Perlstein, W., Ganguli, R., Brar, J., Mintun, M., & Cohen, J. D. (1998). Functional hypofrontality and working memory dysfunction in schizophrenia. American Journal of Psychiatry, 155, 1285-1287.
Carter, C., Robertson, L., Nordahl, T., Chaderjian, M., Kraft, L., & O'Shora-Celaya, L. (1996). Spatial working memory deficit and their relationship to negative symptoms in unmedicated schizophrenia patients. Biological Psychiatry, 40, 930-932.
Chan, R. C. K., Chen, E. Y. H., & Law, C. W. (2006). Specific executive dysfunction in patients with first-episode medication-naive schizophrenia. Schizophrenia Research, 82, 51-64.
Cochet, A., Saoud, M., Gabriele, S., Broallier, V., El Asmar, C., Daléry, J. et al. (2006). Impact de la remédiation cognitive dans la schizophrénie sur les stratégies de résolution de problèmes et l'autonomie sociale: Utilisation du logiciel REHACOM. L'Encéphale, 32, 189-195.
Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences (2nd Ed.) Hillsdale, NJ: Lawrence Erlbaum Associates.
Conklin, H. M., Curtis, C. E., Katsanis, J., & Iacono, W. G. (2000). Verbal working memory impairment in schizophrenia patients and their first-degree relatives: Evidence from the Digit Span task. American Journal of Psychiatry, 157, 275-277.
Coopersmith, S. (1981). Self-Esteem Inventories. Palo Alto, CA: Consulting Psychologists.
Coopersmith, S. (1984). Inventaire D'estime de Soi (SEI). Traduction Française. Paris: Les Editions du Centre de Psychologie Appliquée.
Cornblatt, B. A., Risch, N., Faris, J., Friedman, G., & Erlenmeyer-Kimling, D. (2004). Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Research, 26, 223-238.
Coyette, F., Arno, P., Leclerq, M., Seron, X., Van der Linden, M., & Grégoire, J. (1999). Questionnaire d'Auto-évaluation de l'Attention (QAA). Unpublished document, Centre de Revalidation Neuropsychologique des Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Daban, C., Amado, I., Bourdel, M.-C., Loo, H., Olié, J.-P., Poirier, M.-P. et al. (2005). Cognitive dysfunctions in medicated and unmedicated patients with recent-onset schizophrenia. Journal of Psychiatry Research, 39, 391-398.
Duval, J., & Coyette, F. (2005). Programme de Revalidation de l'Administrateur Central de la Mémoire de Travail. Unpublished document. Louvain: Centre de revalidation neuropsychologique, Cliniques Universitaires Saint-Luc.
Duval, J., Coyette, F., & Seron, X. (2008). Rehabilitation of the central executive component of working memory: A reorganisation approach applied to a single case. Neuropsychological Rehabilitation.(in press).
Galletly, C. A., MacFarlane, A. C., & Clark, C. R. (2007). Impaired updating of working memory in schizophrenia. International Journal of Psychophysiology, 63, 265-274.
Garnier, C., Enot-Joyeux, F., Jokic, C., Le Thiec, F., Desgranges, B., & Eustache, F. (1998). Une évaluation des fonctions exécutives chez les traumatisés crâniens: L'adaptation du test des six éléments. Revue de Neuropsychologie, 8, 385-414.
Goldberg, T. E., Egan, M. F., Gscheidle, T., Coppola, R., Weickert, T., Kolachana, B. S. et al. (2003). Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase val158Met genotype and schizophrenia. Archives of General Psychiatry, 60, 889-896.
Goldstein, G., & Shemansky, W. J. (1995). Influences on cognitive heterogeneity in schizophrenia. Schizophrenia Research, 18, 59-69.
Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry, 153, 321-330.
Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J. (2000). Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the "right stuff"? Schizophrenia Bulletin, 26, 119-136.
Greenwood, K. E., Landau, S., & Wykes, T. (2005). Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapy. Schizophrenia Bulletin, 31, 910-921.
Gur, R. E., Calkins, M. E., Gur, R. C., Horan, W. P., Nuechterlein, K. H., Seidman, L. J. et al. (2007). The consortium on the genetics of schizophrenia: Neurocognitive endophenotypes. Schizophrenia Bulletin, 33, 49-68.
Hiernaux, A., & Demoulin, V. (1999). Questionnaire d'Auto-évaluation de la Mémoire de Travail (QAMT). Unpublished document. Liège: Service de Neuropsychologie des Cliniques Universitaires du Sart-Tilman.
Hofer, A., Baumgartner, S., Bodner, T., Edlinger, M., Hummer, M., Kemmler, G. et al. (2005). Patient outcomes in schizophrenia II: The impact of cognition. European Psychiatry, 20, 395-402.
Joyce, E. M., Hutton, S. B., Mutsatsa, S. H., & Barnes, T. R. E. (2005). Cognitive heterogeneity in first-episode schizophrenia. British Journal of Psychiatry, 187, 516-522.
Joyce, E. M., & Roiser, J. P. (2007). Cognitive heterogeneity in schizophrenia. Current Opinion in Psychiatry, 20, 268-272.
Kay, S. R., Opler, L. A., & Fiszbein, A. (1986). Positive and Negative Syndrome Scale (PANSS), Rating Manual. New York: Albert Einstein College, SF Medicine, Department of Psychiatry.
Krieger, S., Lis, S., Cetin, T., Gallhofer, B., & Meyer-Lindenberg, A. (2005). Executive function and cognitive subprocesses in first-episode, drug-naive schizophrenia: An analysis of n-back performance. American Journal of Psychiatry, 162, 1206-1208.
Lee, J., & Park, S. (2005). Working memory impairments in schizophrenia: A meta-analysis. Journal of Abnormal Psychology, 114, 599-611.
Lépine, J. P., Piron, J. J., & Chapatot, E. (1989). Factor analysis of the PANSS in schizophrenia patients. In C. N. Stefanis, C. R. Soltados, & A. D. Rabavilas (Eds.), Psychiatry Today: Accomplishments and Promises. Amsterdam: Experta Medica.
Mackinnon, A., & Mulligan, R. (2005). Estimation de l'intelligence prémorbide chez les francophones. L'Encéphale, 31, 31-43.
Marsh, R., Alexander, G. M., Packard, M. G., Zhu, H., & Peterson, B. S. (2005). Perceptual-motor skill learning in Gilles de la Tourette syndrome: Evidence for multiple procedural learning and memory systems. Neuropsychologia, 43, 1456-1465.
McGurk, S. R., Twamley, E. W., Sitzer, D. I., McHugo, G. J., & Mueser, K. T. (2007). A meta-analysis of cognitive remediation in schizophrenia. American Journal of Psychiatry, 164, 1791-1802.
Medalia, A., Dorn, H., & Watras-Gans, S. (2000). Treating problem-solving deficits on an acute care psychiatric inpatient unit. Psychiatry Research, 97, 79-88.
Meulemans, T., Coyette, F., & Van der Linden, M. (in preparation). Adaptation et validation du test informatisé de Brown-Peterson.
Mitropoulou, V., Harvey, P. D., Zegarelli, G., New, A. S., Silverman, J. M., & Siever, L. J. (2005). Neuropsychological performance in schizotypal personality disorder: Importance of working memory. American Journal of Psychiatry, 162, 1896-1903.
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000). The unity and diversity of executive functions and their contributions to complex "frontal lobe" tasks: A latent variable analysis. Cognitive Psychology, 41, 49-100.
Myles-Worsley, M., & Park, S. (2002). Spatial working memory deficits in schizophrenia patients and their first degree relatives from Palau, Micronesia. American Journal of Medical Genetics, 114, 609-615.
Nelson, H. E. (1982). National Adult Reading Test. Windsor, UK: NFER-Nelson.
Palladino, P., Cornoldi, C., De Beni, R., & Pazzaglia, F. (2001). Working memory and updating processes in reading comprehension. Memory and Cognition, 29, 344-354.
Park, S., Holzman, P. S., & Lenzenweger, M. F. (1995). Individual differences in spatial working memory in relation to schizotypy. Journal of Abnormal Psychology, 104, 355-363.
Park, S., & McTigue, K. (1997). Working memory and the syndromes of schizotypal personality. Schizophrenia Research, 26, 213-220.
Perlstein, W. M., Dixit, N. K., Carter, C. S., Noll, D. C., & Cohen, J. D. (2003). Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Society of Biological Psychiatry, 53, 25-38.
Prouteau, A., Verdoux, H., Briand, C., Lesage, A., Lalonde, P., Nicole, L. et al. (2004). Self-assessed cognitive dysfunction and objective performance in outpatients with schizophrenia participating in a rehabilitation programme. Schizophrenia Research, 69, 85-91.
Ranganath, C., Cohen, M. X., & Brozinsky, C. J. (2005). Working memory maintenance contributes to long-term memory formation: Neutral and behavioral evidence. Journal of Cognitive Neuroscience, 17, 994-1010.
Reeder, C., Newton, E., Frangou, S., & Wykes, T. (2004). Which executive skills should we target to affect social functioning and symptom change? A study of a cognitive remediation therapy programme. Schizophrenia Bulletin, 30, 87-100.
Reitan, R. M. (1958). Validity of the Trail Making Test as an indication of organic brain damage. Perceptual Motor Skills, 8, 271-276.
Rosenberg, M. (1965). Society and the Adolescent Self Image. Princeton, NJ: Princeton University Press.
Seaton, B. E., Goldstein, G., & Allen, D. N. (2001). Sources of heterogeneity in schizophrenia: The role of neuropsychological functioning. Neuropsychology Review, 11, 45-67.
Seron, X., & Van der Linden, M. (2000). Objectifs et stratégies de la revalidation neuropsychologique. In X. Seron & M. Van der Linden (Eds.), Traité de Neuropsychologie Clinique, Tome II (pp. 9-16). Marseille: Solal.
Shallice, T., & Burgess, P. W (1991). Deficits in strategy application following frontal lobe damage in humans. Brain, 114, 727-741.
Shallice, T., Burgess, P. W., & C. D. Frith (1991). Can the neuropsychological case-study approach be applied to schizophrenia? Psychological Medicine, 21, 621-673.
Silver, H., & Feldman, P. (2005). Evidence for sustained attention and working memory in schizophrenia sharing a common mechanism. Journal of Neuropsychiatry and Clinical Neurosciences, 17, 391-398.
Silver, H., Feldman, P., Bilker, W., & Gur, R. C. (2003). Working memory deficit as a core neuropsychological dysfunction in schizophrenia. American Journal of Psychiatry, 160, 1809-1816.
Stip, E., Caron, J., Renaud, S., Pampoulova, T., & Lecomte, Y. (2003). Exploring cognitive complaints in schizophrenia: The subjective scale to investigate cognition in schizophrenia. Comprehensive Psychiatry, 44, 331-340.
Takahashi, H., Iwase, M., Nakahachi, T., Sekiyama, R., Tabushi, K., Kajimoto, O. et al. (2005). Spatial working memory deficit correlates with disorganization symptoms and social functioning in schizophrenia. Psychiatry and Clinical Neurosciences, 59, 453-460.
Tallent, K. A., & Gooding, D. C. (1999). Working memory and Wisconsin Card Sorting Test performance in schizotypic individuals: A replication and extension. Psychiatry Research, 89, 161-170.
Twamley, E. W., Palmer, B. W., Jeste, D. V., Taylor, M. J., & Heaton, R. K. (2006). Transient and executive function working memory in schizophrenia. Schizophrenia Research, 87, 185-190.
Van der Linden, M., Meulemans, T., Marczewski, P., & Colette, F. (2000). The relationships between episodic memory, working memory, and executive functions: The contribution of the prefrontal cortex. Psychologica Belgica, 40, 275-297.
Van der Linden, M., Wyns, C., Coyette, F., von Frenckell, R., & Seron, X. (1989). Questionnaire d'Auto-évaluation de la Mémoire (QAM). Brussels: Editest.
Van der Linden, M., Adam, S., Agniel, A., Baisset-Mouly, C., Bardet, F., Coyette, F., et al. (2004). L'évaluation des Troubles de la Mémoire: Présentation de Quatre Tests de Mémoire Episodique (avec leur étalonnage). Marseille: Solal.
Wechsler, D. (2000). WAIS-III: Echelle d'Intelligence de Wechsler pour Adultes (3rd ed.). Paris: Les éditions du Centre de Psychologie.
Wechsler, D. (2001). MEM-III: Manuel de l'Echelle Clinique de Mémoire (3rd ed.). Paris: Les éditions du Centre de Psychologie.
Wilson, B. A., Alderman, N., Burgess, P., Emslie, H., & Evans, J. J. (1996). Behavioral Assessment of the Dysexecutive Syndrome (BADS). Bury St. Edmunds, UK: Thames Valley Test Company.
World Health Organization (1980). International Classification of Impairments, Disabilities and Handicaps. Geneva: Author.
Wykes, T., Reeder, C., Corner, J., Williams, C., & Everitt, B. (1999). The effects of neurocognitive remediation on executive processing in patients with schizophrenia. Schizophrenia Bulletin, 25, 291-307.
Wykes, T., Reeder, C., Williams, C., Corner, J., Rice, C., & Everitt, B. (2003). Are the effects of cognitive remediation therapy (CRT) durable? Results from an exploratory trial in schizophrenia. Schizophrenia Research, 61, 163-174.
Zimmerman, P., & Fimm, B. (1994). Test for Attentional Performance (TAP). Herzogenrath, Germany: PsyTest.