[en] Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with the 11 other previously published myeloid-associated t(2p;3q) cases confirms that this nonrandom translocation involves a pluripotent stem cell and is associated with a poor prognosis.
Disciplines :
Hematology Genetics & genetic processes
Author, co-author :
Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > Génétique
Hermanne, Jean-Philippe; Centre Hospitalier Universitaire de Liège - CHU
Tassin, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Fassotte, Marie-France ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Thiry, Albert ; Université de Liège - ULiège > Anatomie pathologique
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