Reference : Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers c...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.
Cerda Cristerna, Bernardino Isaac mailto [Université de Liège - ULg > > > GIGA - Utilisateurs machines]
Flores, Héctor mailto [> >]
Pozos, Amaury mailto [> >]
Sevrin, Chantal mailto [Université de Liège - ULg > > Centre interfacultaire des biomatériaux (CEIB) >]
Grandfils, Christian mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Journal of Controlled Release
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] Poly(2-dimethylamino-ethylmethacrylate) ; Hemocompatibility ; red blood cells ; hemagglutination ; hemolysis ; red blood cell aggregation
[en] Polycations are frequently reported to tailor drug delivery systems,
there is still a need to better correlate theirmacromolecular features with
their biocompatibility, in particular with blood. In this view, we have
analysed the RBC aggregation and hemolysis response caused by poly
(dimethylamino-ethylmethacrylate) or poly(ethyleneimine) under a
free form, i.e. without their preliminary association with polyanionic
drug. Our results highlight that the molecular weight of PDMAEMA
significantly affects theRBC aggregationwithout inducing any hemolysis.
Centre Interfacultaire des Biomatériaux - CEIB
Researchers ; Professionals ; Students

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