ORBi: Cerda Cristerna Bernardino Isaac - Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.

Reference : Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers c...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/100167

Title :	Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.
Language :	English
Author, co-author :	Cerda Cristerna, Bernardino Isaac [Université de Liège - ULg > > > GIGA - Utilisateurs machines]
	Flores, Héctor [> >]
	Pozos, Amaury [> >]
	Sevrin, Chantal [Université de Liège - ULg > > Centre interfacultaire des biomatériaux (CEIB) >]
	Grandfils, Christian [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Publication date :	20-Nov-2010
Journal title :	Journal of Controlled Release
Publisher :	Elsevier Science
Volume :	148
Issue/season :	1
Pages :	e30-e31
Audience :	International
ISSN :	0168-3659
e-ISSN :	1873-4995
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Poly(2-dimethylamino-ethylmethacrylate) ; Hemocompatibility ; red blood cells ; hemagglutination ; hemolysis ; red blood cell aggregation
Abstract :	[en] Polycations are frequently reported to tailor drug delivery systems, there is still a need to better correlate theirmacromolecular features with their biocompatibility, in particular with blood. In this view, we have analysed the RBC aggregation and hemolysis response caused by poly (dimethylamino-ethylmethacrylate) or poly(ethyleneimine) under a free form, i.e. without their preliminary association with polyanionic drug. Our results highlight that the molecular weight of PDMAEMA significantly affects theRBC aggregationwithout inducing any hemolysis.
Research units :	Centre Interfacultaire des Biomatériaux - CEIB
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/100167
DOI :	10.1016/j.jconrel.2010.07.040
Other URL :	http://www.sciencedirect.com/science/article/pii/S0168365910005213

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Open access	10.Increment in Mw of PDMAEMA caused strong RBC aggregation but no hemolysis.Cerda.JCR.pdf		Author postprint	118.08 kB	View/Open

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