http://orbi.ulg.ac.be The ORBi institutional repository system captures, stores, indexes, preserves, and distributes digital research material. Search this channel search http://orbi.ulg.ac.be/simple-search http://hdl.handle.net/2268/212949 Title: Deforestation and timber production in Congo after implementationof sustainable management policy: A reaction to the article by J.S.Brandt, C. Nolte and A. Agrawal (Land Use Policy 52:15–22) <br/> <br/>Author, co-author: Karsenty, Alain; Romero, Claudia; Cerutti, Paolo Omar; Doucet, Jean-Louis; Putz, Francis E.; Bernard, Christelle; Eba'a Atyi, Richard; Douard, Pascal; Claeys, Florian; Desbureaux, Sébastien; Ezzine de Blas, Driss; Fayolle, Adeline; Fomété, Timothée; Forni, Eric; Gond, Valéry; Gourlet-Fleury, Sylvie; Kleinschroth, Fritz; Mortier, Frédéric; Nasi, Robert; Nguinguiri, Jean-Claude; Vermeulen, Cédric; de Wasseige, Carlos <br/> <br/>Abstract: tThis viewpoint paper presents a reaction to the article by Brandt et al. (2016). It highlights the complexitiesinherent to the attribution of deforestation impacts to policy interventions when using remote-sensingdata. This critique argues that in the context of the Congo a suite of factors (i.e., population density inparticular) other than those considered by Brandt et al. (e.g., type of forest, distance from roads and mar-kets) play essential roles in determining the fates of forests. It also contends that care is needed whenmaking decisions regarding which units will be included in the comparison group so that contextual fac-tors and on-the-ground information are properly considered (e.g., when logging operations are inactiveor when a concession is used for ‘conservation’ purposes). Finally, it proposes that a focus on an analysisof deforestation rates for a given level of timber production might be a metric that more accurately rep-resents one aspect of the consequences of forest management, which should also consider the appraisalof trade-offs associated with a larger set of social, financial and ecological objectives. Fri, 14 Jul 2017 09:44:43 GMT http://hdl.handle.net/2268/212948 Title: From local initiatives to territorial transition project: case study of a grassroots food belt project in Liège (Belgium) <br/> <br/>Author, co-author: Feyereisen, Marlène; Stassart, Pierre M; Jonet, Christian <br/> <br/>Abstract: This study analyses a local food initiatives in Liege (Belgium) linked to the Transition Network movement: Ceinture Aliment-Terre Liégeoise (CATL). The study aims to analyse how CATL evolved from a marginal grassroots movement, to a project of transition of the agri-food system which is considered exemplary by Belgian institutional actors. Fri, 14 Jul 2017 08:52:59 GMT http://hdl.handle.net/2268/212947 Title: Étude de cas : Une longue tradition d'enquêtes au Musée de la Vie wallonne <br/> <br/>Author, co-author: Postula, Jean-Louis Fri, 14 Jul 2017 07:43:48 GMT http://hdl.handle.net/2268/212946 Title: Patrimoine culturel immatériel et musée : Acquérir, conserver, étudier, exposer et transmettre <br/> <br/>Author, co-author: Postula, Jean-Louis; Gob, André Fri, 14 Jul 2017 07:36:36 GMT http://hdl.handle.net/2268/212945 Title: Strategic challenges and potential benefits of Open Access publishing: lessons for senior management <br/> <br/>Author, co-author: Rentier, Bernard Fri, 14 Jul 2017 06:45:44 GMT http://hdl.handle.net/2268/212944 Title: Calibration and testing of wide-field UV instruments <br/> <br/>Author, co-author: Frey, Harald; Mende, Stephen; Loicq, Jerôme; Habraken, Serge <br/> <br/>Abstract: As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations difficult is the need for working in vacuum substantially extending the required time and effort compared to visible systems. In theory a ray tracing and characterization of each individual component of the optical system (mirrors, windows, and grating) should provide the transmission efficiency of the combined system. However, potentially unknown effects (contamination, misalignment, and measurement errors) can make the final error too large and unacceptable for most applications. Therefore, it is desirable to test and measure the optical properties of the whole system in vacuum and compare the overall response to the response of a calibrated photon detector. A proper comparison then allows the quantification of individual sources of uncertainty and ensures that the whole instrument performance is within acceptable tolerances or pinpoints which parts fail to meet requirements. Based on the experience with the IMAGE Spectrographic Imager, the Wide-band Imaging Camera, and the ICON Far Ultraviolet instruments, we discuss the steps and procedures for the proper radiometric sensitivity and passband calibration, spot size, imaging distortions, flatfield, and field of view determination. Fri, 14 Jul 2017 06:45:42 GMT http://hdl.handle.net/2268/212943 Title: IN VIVO STUDY OF THE SV2A PROTEIN IN THE KAINIC ACID EPILEPSY RAT MODEL <br/> <br/>Author, co-author: Serrano Navacerrada, Maria Elisa; Becker, Guillaume; Bahri, Mohamed Ali; Warnier, Corentin; Aerts, Joël; Mievis, Frédéric; Giacomelli, Fabrice; Lemaire, Christian; Salmon, Eric; Luxen, André; Plenevaux, Alain <br/> <br/>Abstract: Introduction Epilepsy is one of the commonest neurological disorders [1]. Antiepileptic drugs mainly target the SV2A protein [2] but its actual role is still largely unknown. [18F]UCB-H was developed to study in vivo SV2A brain proteins [3, 4]. The present pilot study was undertaken to evaluate for the first time in vivo in rats SV2A expression in the Kaïnic Acid (KA) epilepsy model [5]. Although this model is well studied in mice, few reports were devoted to rats. Imaging-wise, rats are very interesting thanks to a bigger brain size (reduction of the partial volume effect). Methods Three male Sprague-Dawley were used, one injected with saline and two with multiple KA injections (3 x 5mg/kg) [6]. 75 days later, when spontaneous seizures started to appear, microPET (Focus 120 ) was performed under isoflurane anesthesia (2.5-3 % in air) for 1 hour with [18F]UCB-H (41 ± 5 MBq IV tail vein) followed by MRI (9.4T Agilent, anatomical T2). Coregistration was done with PMOD 3.6 software. Data were expressed as SUV and areas under the curve were calculated for the different regions. Results [18F]UCB-H microPET images showed an important reduction (20-30%) for SV2A after KA injections mainly localized in amygdala, hippocampus, lateral parietal association cortex and cingulate cortex. The rest of the brain was globally unchanged. MRI revealed atrophy and inflammation in amygdala and hippocampus. Conclusions These preliminary results obtained in KA treated rats showed that [18F]UCB-H was able to detect important modifications for SV2A in relevant regions for epilepsy and appears as a valuable tool to follow in vivo SV2A through longitudinal studies. KA model in rats deserves for further development and validation as a tool for the study of epilepsy. Fri, 14 Jul 2017 04:33:36 GMT http://hdl.handle.net/2268/212942 Title: Evaluating the specificity of [18F] UCB-H for the isoform SV2A, compared with isoforms SV2B and SV2C <br/> <br/>Author, co-author: Serrano Navacerrada, Maria Elisa; Becker, Guillaume; Bahri, Mohamed Ali; Warnier, Corentin; Aerts, Joël; Mievis, Frédéric; Giacomelli, Fabrice; Lemaire, Christian; Salmon, Eric; Luxen, André; Plenevaux, Alain <br/> <br/>Abstract: Background: SV2A is the most studied isoform of the Synaptic Vesicle 2 proteins, which are involved in the synaptic vesicle trafficking, being important in normal and pathological process, like the epilepsy (1, 2). [18F]UCB-H was developed like a tool to study the role of this isoform with neuroimaging techniques (3, 4). The objective of this study was to evaluate its specificity to this isoform comparing with the others, through a competition assay in rats with ex-vivo autoradiography and mPET imaging. Methods: Forty male Sprague-Dawley were used in ex-vivo autoradiography experiments (N=20) and in microPET imaging (N=20). Animals were pre-treated 30 minutes before the injection of [18F]UCB-H with a dose IP either of vehicle, Keppra (SV2A ligand), UCB068 (SV2B ligand) or UCB054 (SV2C ligand). Ex-vivo autoradiography was carried out 5 minutes after radiotracer injection while mPET images were acquiring with a dynamic scanner of 1 hour. Data were expressed in Standard Uptake Value and then, the area under the curve was calculated for the total process. Results: In ex-vivo autoradiography, ANOVA of two-ways showed statistical significant differences in brain uptake of [18F]UCB-H among the groups pretreated with Keppra or the ligand for SV2B and the control group. Regarding mPET data, statistical significant differences were found between the group injected with keppra and the rest of groups. Conclusion: Even if a considerable affinity between the ligands UCB068 and UCB054, and the receptor for the isoform SV2A exists, it is only detected during the first 5 minutes (ex-vivo technique), being certainly due to a nonspecific binding. This binding is not strong enough to show a direct competition with the radiotracer during a mPET acquisition. These results allow us to conclude that [18F]UCB-H is a suitable radiotracer for the imaging of the isoform SV2A in vivo, allowing us the clinical study about the molecular base of a disease with a high population impact, like the epilepsy. Fri, 14 Jul 2017 04:33:21 GMT http://hdl.handle.net/2268/212941 Title: Temporality of Features in Near-Death Experience Narratives <br/> <br/>Author, co-author: Martial, Charlotte; Cassol, Helena; Antonopoulos, Georgios; Charlier, Thomas; Héros, Julien; Donneau, Anne-Françoise; Charland-Verville, Vanessa; Laureys, Steven <br/> <br/>Abstract: Background: After an occurrence of a Near-Death Experience (NDE), Near- Death Experiencers (NDErs) usually report extremely rich and detailed narratives. Phenomenologically, a NDE can be described as a set of distinguishable features. Some authors have proposed regular patterns of NDEs, however, the actual temporality sequence of NDE core features remains a little explored area. Objectives: The aim of the present study was to investigate the frequency distribution of these features (globally and according to the position of features in narratives) as well as the most frequently reported temporality sequences of features. Methods: We collected 154 French freely expressed written NDE narratives (i.e., Greyson NDE scale total score 7/32). A text analysis was conducted on all narratives in order to infer temporal ordering and frequency distribution of NDE features. Results: Our analyses highlighted the following most frequently reported sequence of consecutive NDE features: Out-of-Body Experience, Experiencing a tunnel, Seeing a bright light, Feeling of peace. Yet, this sequence was encountered in a very limited number of NDErs. Conclusion: These findings may suggest that NDEs temporality sequences can vary across NDErs. Exploring associations and relationships among features encountered during NDEs may complete the rigorous definition and scientific comprehension of the phenomenon. Fri, 14 Jul 2017 04:32:53 GMT http://hdl.handle.net/2268/212940 Title: Specification guidelines for surface preparation of concrete prior to repair <br/> <br/>Author, co-author: Courard, Luc; Bissonnette, Benoît; Garbacz, Andrzej <br/> <br/>Abstract: The repair of concrete requests specific preparation operations needed for guaranteeing compatibility between substrate and new materials as well as the development of adhesion properties. These specification guidelines contain design and construction recommendations for surface preparation of concrete for repair and overlay. The paper summarizes current knowledge, best practices and results of the research concerning the surface preparation of concrete prior to application of repair/overlay materials. The specifications are applicable to repairing damaged or deteriorated concrete structures, correcting design or construction deficiencies, or upgrading a structure for new uses, or to meet more restrictive code requirements. This is based on 10 years research activities on this topic through scientific cooperation programs between Wallonia, Quebec and Poland and support of American Concrete Institute. Fri, 14 Jul 2017 04:32:17 GMT http://hdl.handle.net/2268/212939 Title: ROLE OF IMAGING IN LEFT ATRIAL APPENDAGE OCCLUSION <br/> <br/>Author, co-author: LEMPEREUR, Mathieu; AMINIAN, Adel; DULGHERU, Raluca Elena; DE POTTER, Tom; Oury, Cécile; LANCELLOTTI, Patrizio Fri, 14 Jul 2017 04:30:34 GMT http://hdl.handle.net/2268/212938 Title: A NASICON-type material as positive electrode in Li-ion and Na-ion batteries <br/> <br/>Author, co-author: Eshraghi, Nicolas Thu, 13 Jul 2017 15:19:26 GMT http://hdl.handle.net/2268/212937 Title: A NASICON-type material as positive electrode in Li-ion and Na-ion batteries <br/> <br/>Author, co-author: Eshraghi, Nicolas Thu, 13 Jul 2017 15:15:09 GMT http://hdl.handle.net/2268/212936 Title: Designing an air-to-air heat exchanger dedicated to single room ventilation with heat recovery <br/> <br/>Author, co-author: Gendebien, Samuel; Martens, Jonathan; Prieels, Luc; Lemort, Vincent <br/> <br/>Abstract: The present paper focuses on the development steps of heat exchangers dedicated to single room ventilation unit with heat recovery (SRVHR) by proposing a numerical approach. A methodology is suggested in order to determine the best trade-off between hydraulic and thermal performance given a specific geometry. The methodology consists in a mapping of the coefficient of performance (COP) of the unit. The latter is defined as the ratio between recovered heat and the fan energy use, given a specific indoor/outdoor temperature difference. However, the energy performance should not be the only criterion to be taken into account in the frame of the design steps of a heat recovery exchanger: technical, economic and acoustic aspects should also be considered. This numerical methodology is illustrated by means of a real example of a newly developed heat exchanger dedicated to a SRVHR. The optimization is first performed while using a semi-empirical model (based on the use of correlations and on a spatial division of the studied heat exchanger). The semi-empirical model allows for the creation of a COP map in order to identify the most effective geometry parameters for the heat exchanger. The decision concerning the final geometry is made accounting for the so-called technical, economic and acoustic considerations. A discussion on some parameters needed for the COP establishment is also proposed. Thu, 13 Jul 2017 14:00:33 GMT http://hdl.handle.net/2268/212935 Title: IN VIVO STUDY OF THE SV2A PROTEIN IN AN EPILEPTIC RAT MODEL <br/> <br/>Author, co-author: Serrano Navacerrada, Maria Elisa; Becker, Guillaume; Bahri, Mohamed Ali; Warnier, Corentin; Aerts, Joël; Mievis, Frédéric; Giacomelli, Fabrice; Lemaire, Christian; Salmon, Eric; Luxen, André; Plenevaux, Alain <br/> <br/>Abstract: Introduction Epilepsy is one of the commonest neurological disorders, affecting more than 60 million people worldwide [1]. New and effective antiepileptic drugs mainly target the SV2A protein [2] but its actual role is still largely unknown. [18F]UCB-H was developed as a tool to study in vivo the brain expression of this isoform [3, 4]. Due to the fact that only post-mortem studies were reported so far [5] the present pilot study was undertaken in order to evaluate for the first time in vivo in rats the SV2A expression in the validated Kaïnic Acid (KA) epilepsy model [6]. Methods Three male Sprague-Dawley were used, one injected with saline (Sham) and two with multiple KA systemic injections (5mg/kg x 3) [9]. SV2A brain levels were estimated at day 75, when spontaneous seizures started to appear. Animals were anesthetized (2.5 to 3 % isoflurane), and scanned for 1 hour with [18F]UCB-H (41 ± 5 MBq IV tail vein) in a Focus 120 microPET system and with MRI (9.4T Agilent, anatomical T2). Coregistration was done with PMOD 3.6 software. Data were expressed in SUV and areas under the curve were calculated for the different regions. Results [18F]UCB-H microPET images showed an important reduction (20-30%) for SV2A after KA injections mainly localized in amygdala, hippocampus, lateral parietal association cortex and cingulate cortex. The rest of the brain was globally unchanged. MRI revealed atrophy and inflammation in amygdala and hippocampus. Conclusions These preliminary results in KA treated rats presenting spontaneous seizures showed that [18F]UCB-H microPET was able to detect important reductions for the SV2A proteins in relevant regions for epilepsy [5]. Accordingly to this, we can infer that the KA model in rats deserves for further development and validation as a tool for the study of epilepsy. [18F]UCB-H appears as a valuable tool to follow in vivo SV2A proteins through longitudinal protocols and in turn to better understand its actual role in epilepsy. References/acknowledgements This work was funded by University of Liège, F.R.S.-FNRS, Walloon Region and UCB Pharma. Alain Plenevaux is research director from F.R.S.-FNRS. [1] Alexopoulos, Epileptology, 2004 [2] Hamann et al., Eur J Pharmacol, 2008 [3] Bretin et al., Molecular Imaging and Biology, 2015 [4] Warnock et al., J Nucl Med., 2014 [5] Wang et al., J Mol Neurosci., 2014 [6] Hellier et al., Epilepsy Res., 1998 Thu, 13 Jul 2017 12:50:25 GMT http://hdl.handle.net/2268/212934 Title: [18F]UCB-H RADIOTRACER AS A TOOL TO UNDERSTAND THE ROLE OF THE SV2A PROTEIN <br/> <br/>Author, co-author: Serrano Navacerrada, Maria Elisa; Becker, Guillaume; Bahri, Mohamed Ali; Warnier, Corentin; Aerts, Joël; Mievis, Frédéric; Giacomelli, Fabrice; Lemaire, Christian; Salmon, Eric; Luxen, André; Plenevaux, Alain <br/> <br/>Abstract: Background: SV2A is the most studied isoform of the Synaptic Vesicle 2 proteins, which are involved in the synaptic vesicle trafficking, being important both in normal as in pathological process (1, 2). Until now, only one study in vivo has been reported, showing a reduction of SV2A levels in the epilepsy (3). [18F]UCB-H was developed like a current tool to study the role of SV2A with in vivo techniques (4, 5), and as a tool in clinical investigations. The objective of this research was to evaluate the radiotracer specificity to this isoform comparing with the others, through a competition assay in rats with ex-vivo autoradiography and mPET imaging. Methods: Forty male Sprague-Dawley were used in ex-vivo autoradiography experiments (N=20) and in microPET imaging (N=20). Animals were pre-treated 30 minutes before the injection of [18F]UCB-H with a dose IP either of vehicle, Keppra (SV2A ligand), UCB068 (SV2B ligand) or UCB054 (SV2C ligand). Ex-vivo autoradiography was carried out 5 minutes after radiotracer injection while mPET images were acquiring with a dynamic scanner of 1 hour. Standard Uptake Value (SUV) and Distribution Volume (VT) were calculated and the correlation between both parameters was determined. Results: In ex-vivo autoradiography, ANOVA of two-ways showed statistical significant differences in brain uptake of [18F]UCB-H among the groups pretreated with Keppra or the ligand for SV2B and the control group. Regarding mPET data, statistical significant differences were found between the group injected with keppra and the rest of groups. Pearson Correlation between SUV and VT was strong, with a value of 0.955. Conclusion: Even if a considerable affinity between the ligands UCB068 and UCB054, and the receptor for the isoform SV2A exists, it is only detected during the first 5 minutes (ex-vivo technique), being certainly due to a nonspecific binding. This binding is not strong enough to show a direct competition with the radiotracer during a mPET acquisition. These results allow us to conclude that [18F]UCB-H is a suitable radiotracer for the imaging of the isoform SV2A in vivo, allowing us the clinical study about the molecular base of a disease with a high population impact, like the epilepsy. 1) Van Vliet et al., 2009. Epilepsia 2) Crèvecœur et al., 2013. BMC Neurosci. 3) Finnema et al., 2016; Sci Transl Med. 4) Bretin et al., 2013.EJNMMI Res 5) Bretin et al., 2015.Mol Imaging Biol Thu, 13 Jul 2017 12:49:30 GMT http://hdl.handle.net/2268/212933 Title: A damage to crack transition model accounting for stress triaxiality formulated in a hybrid non-local implicit discontinuous Galerkin - cohesive band model framework <br/> <br/>Author, co-author: Leclerc, Julien; Wu, Ling; Nguyen, Van Dung; Noels, Ludovic <br/> <br/>Abstract: Modelling the entire ductile fracture process remains a challenge. On the one hand, continuous damage models succeed in capturing the initial diffuse damage stage but are not able to represent discontinuities or cracks. On the other hand, discontinuous methods, as the cohesive zones, which model the crack propagation behaviour, are suited to represent the localised damaging process. However, they are unable to represent diffuse damage. Moreover, most of the cohesive models do not capture triaxiality effect. In this paper, the advantages of the two approaches are combined in a single damage to crack transition framework. In a small deformation setting, a non-local elastic damage model is associated with a cohesive model in a discontinuous Galerkin finite element framework. A cohesive band model is used to naturally introduce a triaxiality-dependent behaviour inside the cohesive law. Practically, a numerical thickness is introduced to recover a 3D-state, mandatory to incorporate the in-plane stretch effects. This thickness is evaluated to ensure the energy consistency of the method and is not a new numerical parameter. The traction-separation law is then built from the underlying damage model. Thu, 13 Jul 2017 11:20:16 GMT http://hdl.handle.net/2268/212932 Title: Language and analogical reasoning in children with Specific Language Impairment: The effect of articulatory suppression <br/> <br/>Author, co-author: Krzemien, Magali; Thibaut, Jean-Pierre; Stoffels, Valentine; Maillart, Christelle <br/> <br/>Abstract: Analogical reasoning shares a mutual influence with language development: analogical reasoning is improved by labelling analogical items with words describing the relations that they contain. Conversely, structural alignment, a core mechanism of analogical reasoning, allows the acquisition of novel words and the development of grammar (Gentner, 2010). Given those findings, some authors have taken interest in the analogical reasoning ability of children with language disorders, and specifically of children with Specific Language Impairment (SLI). Those children have worse performance than their age-matched peers without language disorders in linguistic or non-linguistic analogical tasks (Leroy, Maillart, & Parisse, 2014). Our aim here is to see if this weakness is due to their language disorders and if they use the same verbal strategies as their peers to solve an analogical task. To experience these assumptions, we use a perceptual analogical task following an A:B::C:D paradigm: participants have to find the relation between two geometric forms A and B and to apply it to the C term in order to find the D term among distractors. The distractors either share perceptual features with the C term, what creates a competition that shall be inhibited, or not. Moreover, children are faced with three interfering task conditions: one without any interfering task, one with an articulatory suppression secondary task and one with a tapping secondary task, which is used in order to measure the general dual task demands. Comparing the results of these conditions will allow us to evaluate the impact of language and verbal strategies on analogical reasoning in control and SLI children. Thu, 13 Jul 2017 10:00:31 GMT http://hdl.handle.net/2268/212931 Title: Biologie, diversité et outils pour l'analyse de la diversité génétique de l'oignon, Allium cepa L. (synthèse bibliographique) <br/> <br/>Author, co-author: Rabiou, Abdou; Bakasso, Yacoubou; Adam, Toudou; Saadou, Mahamane; Baudoin, Jean-Pierre <br/> <br/>Abstract: Cette étude synthétise les principaux résultats sur la biologie de l'oignon, les ressources phytogénétiques, la position taxonomique ainsi que les marqueurs morphologiques, biochimiques et moléculaires pour l'analyse de la diversité génétique de l'oignon, avec une attention particulière pour l'Afrique. Plante monocotylédone, allogame, entomophile, avec une cycle cultural annuel pour la production des bulbes, bisannuel pour celles des graines, l'oignon est l'un des légumes les plus importants au monde en raison de son utilisation en alimentation et en médecine.; This study explores important information on biology, genetic resources, taxonomy, as well as morphological, biochemical and molecular markers in order to provide a better understanding of the genetic diversity of the onion (Allium cepa L.). The study has a particular focus on the plant as grown in Africa. The onion is a monocotyledonous, allogamous, and entomophilous plant, with a one-year production cycle for bulb production, and a two-year production cycle for seeds. The onion is one of the most significant vegetables in the world because of its use as both a food and a médicine. Thu, 13 Jul 2017 09:57:25 GMT http://hdl.handle.net/2268/212930 Title: Analyse de la diversité des cultivars d'oignon (Allium cepa L.) du Niger en vue de leur consrvation et de leur amélioration <br/> <br/>Author, co-author: Abdou, Rabiou; Zakari, Mounir; Bakasso, Yacoubou; Saadou, Mahamane; Baudoin, Jean-Pierre Thu, 13 Jul 2017 09:56:14 GMT