http://hdl.handle.net/2268/92 Search this channel search http://orbi.ulg.ac.be/simple-search http://hdl.handle.net/2268/150763 Title: Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations in PER3 polymorphism under sleep deprivation <br/> <br/>Author, co-author: Muto, Vincenzo; Meyer, Christelle; Jaspar, Mathieu; Shaffii-LeBourdiec, Anahita; Chellappa, Sarah Laxhmi; Vandewalle, Gilles; Collette, Fabienne; Archer, Simon; Dijk, Derk Jan; MAQUET, Pierre Tue, 18 Jun 2013 14:55:09 GMT http://hdl.handle.net/2268/150752 Title: Technical and clinical evaluation of the VITROS Immunodiagnostic Products 25-OH Vitamin D Total Assay - comparison with marketed automated immunoassays and a liquid chromatography - tandem mass spectrometry method <br/> <br/>Author, co-author: CAVALIER, Etienne; ROUSSELLE, Olivier; FERRANTE, Nunzio; CARLISI, Ignazia; LE GOFF, Caroline; Souberbielle, Jean-Claude <br/> <br/>Abstract: Background: The study was conducted to evaluate the technical and clinical performance of the VITROS ® Immunodiagnostic Products 25-OH Vitamin D Total Assay, and compare it with the performance of five marketed automated assays and a liquid chromatography/mass spectrometry reference method (LC-MS/MS). Methods: Three hundred patient serum samples were used to compare the correlation of the VITROS ® 25-OH Vitamin D Total Assay with both the other immunoassays and the LC-MS/MS method, using Passing-Bablok regression and Bland-Altman analyses. Concordance of the diagnosis of vitamin D status was calculated to test the agreement between the different assays. In addition, samples containing vitamin D2 were used to test the assay ’ s ability to detect the D2 form of the vitamin. Results and conclusions: These results from the VITROS ® 25-OH Vitamin D Total Assay generally correlated well with those from most of the marketed immunoassays. Cross-reactivity of the D2 form was calculated as being close to 100%. Additionally, we found substantial variability in performance amongst the various assays, which suggests the need for optimisation and recalibration of commercial methods. Tue, 18 Jun 2013 12:54:58 GMT http://hdl.handle.net/2268/150750 Title: Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials. <br/> <br/>Author, co-author: Franquesa, Marcella; Hoogduijn, Martin J.; Reinders, Marlies E.; Eggenhofer, Elke; Engela, Anja U.; Mensah, Fane K.; Torras, Joan; Pileggi, Antonello; van Kooten, Cees; Mahon, Bernard; DETRY, Olivier; Popp, Felix C.; Benseler, Volker; Casiraghi, Federica; Johnson, Christian; Ancans, Janis; Fillenberg, Barbara; Delarosa, Olga; Aran, Josep M.; Roemeling-Vanrhijn, Marieke; Pinxteren, Jef; Perico, Norberto; Gotti, Eliana; Christ, Bruno; Reading, James; Introna, Martino; Deans, Robert; Shagidulin, Murat; Farre, Ramon; Rambaldi, Alessandro; Sanchez-Fueyo, Albert; Obermajer, Natasha; Pulin, Andrey; Dor, Frank J. M. F.; Portero-Sanchez, Isabel; Baan, Carla C.; Rabelink, Ton J.; Remuzzi, Giuseppe; Betjes, Michiel G. H.; Dahlke, Marc H.; Grinyo, Josep M. <br/> <br/>Abstract: The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies. Tue, 18 Jun 2013 11:36:54 GMT http://hdl.handle.net/2268/150693 Title: Multisegmented radiation therapy as an alternative to 3D conformal radiation therapy, with special reference to breast cancer tangential fields <br/> <br/>Author, co-author: GULYBAN, Akos; Kovacs, P.; Farkas, R.; Sebestyen, Z.; Derczy, K.; Hideghety, K.; Esik, O. <br/> <br/>Abstract: The paper compares the techniques of 3DCRT and MSCRT in terms of PTV coverage and doses to OARs. The study population consisted of 175 breast cancer patients in whom treatement was analysed in regard to the use of lateral and medial tangential fields. Although we have failed to establish statistical significance at the P=0.05 levelthe results look clinically promising in favour of MSCRT. Tue, 18 Jun 2013 04:42:59 GMT http://hdl.handle.net/2268/150692 Title: Improving patient positioning accuracy for breast cancer radiation therapy by using the infra red based ExacTrac system <br/> <br/>Author, co-author: GULYBAN, Akos; Hortobágyi, E.; Sebestyén, Z.; Kovács, P.; Liposits, G.; Farkas, R.; Hideghéty, K.; Mangel, L.; Ésik, O. <br/> <br/>Abstract: We report on a pilot study to investigate for cancer of the breast, the accuracy of patient positioning with the normal standard method (ST) and with the standard method extended with the ExacTrac system (ET). Our work in progress pilot study population consisted of four patients: two positioned using ST and two positioned using ET. The results from the daily electronic portal images showed that with ExacTrac the positional accuracy could be unproved by 50% but with a corresponding increase in overall treatment time of about 2 minutes. Tue, 18 Jun 2013 04:34:09 GMT http://hdl.handle.net/2268/150662 Title: Hysteroscopic resection of abnormally invasive placenta residuals. <br/> <br/>Author, co-author: Nisolle, Michelle; DELBECQUE, Katty; PERRIER d'HAUTERIVE, Sophie; FIRQUET, Anne; CHANTRAINE, Frédéric <br/> <br/>Abstract: OBJECTIVE: To present our experience in hysteroscopic removal of abnormally invasive placenta (AIP) residuals using bipolar energy. DESIGN: Case series. SETTING: University hospital. POPULATION: Sixteen patients with AIP residuals after 17 pregnancies. METHODS: Cases were identified by ultrasound, treated with hysteroscopic bipolar electrosurgery and oral contraceptives, and followed up by ultrasound or hysteroscopy. Nine subsequent pregnancies were described. MAIN OUTCOME MEASURES AND RESULTS: Complete removal of AIP residuals was achieved by hysteroscopic bipolar electrosurgery in all cases except one. No peroperative complications occurred. AIP residual recurred in one patient after a subsequent pregnancy and was successfully treated using the same procedure. CONCLUSIONS: AIP residual is a rare condition. Management by hysteroscopic resection using bipolar energy is save and feasible. Mon, 17 Jun 2013 11:19:09 GMT http://hdl.handle.net/2268/150661 Title: Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation. <br/> <br/>Author, co-author: Coudyzer, Pauline; Lemoine, Pascale; Jordan, Benedicte F.; Gallez, Bernard; Galant, Christine; Nisolle, Michelle; Courtoy, Pierre J.; Henriet, Patrick; Marbaix, Etienne <br/> <br/>Abstract: Menstrual endometrial breakdown induced by estradiol and progesterone withdrawal is regularly attributed to vasospasm of spiral arteries causing ischemia and hypoxia. We investigated whether hypoxia actually occurred in an in vivo model of menstruation. Three complementary approaches were used to look for signs of hypoxia in fragments of human functionalis xenografted to ovariectomized immunodeficient mice bearing pellets-releasing estradiol and progesterone, and then deprived of ovarian steroids. Hormone withdrawal 21 d after grafting induced menstrual breakdown and MMP expression within 4 d. Local partial oxygen pressure (pO2) was measured by electron paramagnetic resonance using implanted lithium phtalocyanine crystals. In mice with hormone maintenance until sacrifice, pO2 was low one week after grafting (14.8+/-3.4 mmHg) but increased twofold from the second week when tissue was largely revascularized. After 3 wk, pO2 was not modified by hormone withdrawal but was slightly increased on hormone reimpregnation 4 d after removal (34.7+/-6.1 mmHg) by comparison with hormone maintenance (27.1+/-8.6 mmHg). These results were confirmed using fluorescence quenching-based OxyLite measurements. In a further search for signs of hypoxia, we did not find significant HIF1-alpha immunostaining, nor pimonidazole adducts after hormone withdrawal. We conclude that hypoxia is not needed to trigger menstrual-like tissue breakdown or repair in human endometrial xenograft.-Coudyzer, P., Lemoine, P., Jordan, B. F., Gallez, B., Galant, C., Nisolle, M., Courtoy, P. J., Henriet, P., and Marbaix, E. Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation. Mon, 17 Jun 2013 11:18:11 GMT http://hdl.handle.net/2268/150655 Title: Falsification des médicaments: mythe ou réalité ? <br/> <br/>Author, co-author: Marini Djang'Eing'A, Roland; Fillet, Marianne; Vancauwenberghe, Roy; Crommen, Jacques; Frederich, Michel; Hubert, Philippe <br/> <br/>Abstract: La santé publique est de nos jours minée par la problématique des médicaments falsifiés ou de qualité inférieure, avec plusieurs conséquences sanitaires, économiques voire professionnelles. On estime à 7% la part du marché pharmaceutique mondial que représenterait ce fléau; l’Afrique, l’Asie et de nombreux pays d'Amérique latine étant les régions les plus touchées avec plus de 30% de médicaments falsifiés. D’après l'OMS, plus de 50% des médicaments achetés à partir des sites internet illégaux sont contrefaits, annihilant très fortement les chances de succès thérapeutique. Ces médicaments viennent dans la plupart des cas des pays asiatiques et de l’Eurasie. Le trafic de faux médicaments est un crime contre l'humanité qui représente environ 50 milliards de dollars par an (10-15 % de plus que le marché de la drogue). Au travers de deux leçons, la situation de la falsification des médicaments sera présentée au grand public dans le but de le sensibiliser à ce fléau. La première leçon présentera la situation en Europe avec un accent sur la Belgique. La problématique du droit à la propriété intellectuelle et de l’encadrement législatif sera abordée, ainsi que la falsification des médicaments modernes et des phytomédicaments, ces derniers étant utilisés par plus de 40% de la population en Europe et aux Etats-Unis. Dans la seconde leçon sera abordée la situation vécue en Afrique. L’approvisionnement en médicaments de qualité par le partage de l’information sera présenté ainsi que les moyens analytiques à la disposition de ce continent pour combattre ce fléau. Des membres du Département de Pharmacie de l’Université de Liège, de l’Agence Fédérale des Médicaments et des Produits de Santé ainsi que du programme QUAMED (Quality Medicines for All) feront partager leur expérience sur cette question d’une brûlante actualité.  Mon, 17 Jun 2013 09:53:30 GMT http://hdl.handle.net/2268/150619 Title: Effect of low concentration of tetracycline solution on collagen membrane biodegradation: a rat study <br/> <br/>Author, co-author: LECLOUX, Geoffrey; GRENADE, Charlotte; PEVEE, Jean Michel; LAMBERT, France; ROMPEN, Eric Sun, 16 Jun 2013 16:02:11 GMT http://hdl.handle.net/2268/150616 Title: Roxolid a new implant material <br/> <br/>Author, co-author: LAMBERT, France; ROMPEN, Eric Sun, 16 Jun 2013 15:29:39 GMT http://hdl.handle.net/2268/150615 Title: Roxolid a new implant material <br/> <br/>Author, co-author: LAMBERT, France; ROMPEN, Eric Sun, 16 Jun 2013 15:28:55 GMT http://hdl.handle.net/2268/150599 Title: Oral Photography <br/> <br/>Author, co-author: LAMBERT, France Sun, 16 Jun 2013 14:38:31 GMT http://hdl.handle.net/2268/150595 Title: Persistent Organochlorine Pollutants with Endocrine Activity and Blood Steroid Hormone Levels in Middle- Aged Men <br/> <br/>Author, co-author: Emeville, Elise; Giton, Frank; Giusti, Arnaud; Oliva, Alejandro; Fiet, Jean; Thomé, Jean-Pierre; Blanchet, Pascal; Multigner, Luc <br/> <br/>Abstract: Abstract Background: Studies relating long-term exposure to persistent organochlorine pollutants (POPs) with endocrine activities (endocrine disrupting chemicals) on circulating levels of steroid hormones have been limited to a small number of hormones and reported conflicting results. Objective: We examined the relationship between serum concentrations of dehydroepiandrosterone, dehydroepiandrosterone sulphate, androstenedione, androstenediol, testosterone, free and bioavailable testosterone, dihydrotestosterone, estrone, estrone sulphate, estradiol, sex-hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone as a function of level of exposure to three POPs known to interfere with hormone-regulated processes in different way: dichlorodiphenyl dichloroethene (DDE), polychlorinated biphenyl (PCB) congener 153, and chlordecone. Methods: We collected fasting, morning serum samples from 277 healthy, non obese, middle-aged men from the French West Indies. Steroid hormones were determined by gas chromatography-mass spectrometry, except for dehydroepiandrosterone sulphate, which was determined by immunological assay, as were the concentrations of sex-hormone binding globulin, follicle-stimulating hormone and luteinizing hormone. Associations were assessed by multiple linear regression analysis, controlling for confounding factors, in a backward elimination procedure, in multiple bootstrap samples. Results: DDE exposure was negatively associated to dihydrotestosterone level and positively associated to luteinizing hormone level. PCB 153 was positively associated to androstenedione and estrone levels. No association was found for chlordecone. Conclusions: These results suggested that the endocrine response pattern, estimated by determining blood levels of steroid hormones, varies depending on the POPs studied, possibly reflecting differences in the modes of action generally attributed to these compounds. It remains to be investigated whether this response pattern is predictive of the subsequent occurrence of disease. Sun, 16 Jun 2013 11:59:26 GMT http://hdl.handle.net/2268/150592 Title: Revisited rules of papilla level adjacent to single-tooth dental implants according recent implant designs. A retrospective study. <br/> <br/>Author, co-author: LECLOUX, Geoffrey; Beaujan, Laurie; ROMPEN, Eric; LAMBERT, France <br/> <br/>Abstract: Background: According to Choquet and Tarnow principles (2001), a papilla is always present if the distance from the base of the contact point between two crowns to the crest of the bone is 5 mm or less. The arrival of new designs in implantology suggested more tissue preservation and so a possible evolution for the aesthetic treatments. Aim: This study was designed to determine whether the distance from the base of the contact point to the crest of the bone would correlate with the presence or absence of the interproximal papillae adjacent to single-tooth implants using the recent implant designs. Methods: A clinical, photographical and radiographical retrospective evaluation of the papilla level around single dental implants and their adjacent teeth was performed in the anterior maxilla in 34 patients restored with 39 implants. These implants were loaded at least 6 months and present a modified profile (Implants : NobelConcept and NobelActive, Nobel Biocare ; Bone Level, Straumann. Abutments : Platform-switching and curvy). Sixty-three papillae were available for evaluation. The Jemt index, the vertical distance between the base of the contact point and the bone crest, the distance from the papilla level to the contact point were measured. The measurements were rounded off to the nearest 0,001 millimeter and used with calibration computer programs (ImageJ) to be analyzed. The statistical analyses were realized with SAS program (SAS Institute, Cary, NC, USA). Results: When the measurements from the contact point to the crest of bone was 5 mm or less, the papilla was present 100% of the time. When the distance was 6 mm, the papilla was present 96% of the time. And when the distance was 7 and 8 mm, the papilla was present 57,14% and 50% of the time. Conclusions and clinical implications: These results show the influence of the bone crest on the presence or absence of papillae between implants and adjacent teeth. The data also show a positive influence for recent designs of implant and abutment systems. This designs shift the actual critical bone distance under the contact point from 5mm to 6mm and could improve the aesthetic outcome. Sun, 16 Jun 2013 11:33:02 GMT http://hdl.handle.net/2268/150585 Title: Evaluation of a technique for ridge preservation after tooth extraction 'saddle connective tissue graft and BHA' <br/> <br/>Author, co-author: LECLOUX, Geoffrey; ROMPEN, Eric; LAMBERT, France; RAEPSAET, Nicolas Sun, 16 Jun 2013 11:08:09 GMT http://hdl.handle.net/2268/150583 Title: One-piece zirconium implant with concave transmucosal profile: an 18 month prospective study <br/> <br/>Author, co-author: LAMBERT, France; ROMPEN, Eric Sun, 16 Jun 2013 11:02:48 GMT http://hdl.handle.net/2268/150570 Title: Les sutures en dentisterie : cours théorique et travaux pratiques <br/> <br/>Author, co-author: LAMBERT, France Sun, 16 Jun 2013 10:38:52 GMT http://hdl.handle.net/2268/150569 Title: Mise en charge immédiate en zone esthétique avec un pilier zircone préformé <br/> <br/>Author, co-author: COMPEYRON, Yoann; LECLOUX, Geoffrey; LEGROS, Caroline; ROMPEN, Eric; LAMBERT, France Sun, 16 Jun 2013 10:37:37 GMT http://hdl.handle.net/2268/150568 Title: Placement précoce d’implant dans des sites d’extractions préservés : résultats à 1 an. <br/> <br/>Author, co-author: DETHIER, Frédéric; LECLOUX, Geoffrey; ROMPEN, Eric; LAMBERT, France Sun, 16 Jun 2013 10:37:12 GMT http://hdl.handle.net/2268/150567 Title: extractions dentaires et risque d'ostéonécrose de la mâchoire chez les patients traités par bisphosphonates en intraveineuse <br/> <br/>Author, co-author: GAUDIN, Elise; HERION, Francine; LECLOUX, Geoffrey; ROMPEN, Eric; LAMBERT, France Sun, 16 Jun 2013 10:26:03 GMT