http://hdl.handle.net/2268/115 Search this channel search http://orbi.ulg.ac.be/simple-search http://hdl.handle.net/2268/148051 Title: PET-CT and PET-MRI in Oncology, A practical Guide: Gastrointestinal (135-159) <br/> <br/>Author, co-author: HUSTINX, Roland <br/> <br/>Abstract: PET-CT combines in a single imaging session both anatomical and metabolic information. Depending on the strategy, the CT part of the study may yield only crude anatomical information and attenuation correction for the PET part, or it may offer full radiological diagnostic features. Regarding the radiotracers for gastrointectinal oncology, FDG remains the mainstay but alternative compounds aimed at more specific biological targets are actively tested. In particular Ga-68-labelled DOTA derivatives image somatostatine receptors with exquisite sensitivity and specificity. In clinical practice, several indications are well recognized for FDG PET-CT. These include the initial staging of esophageal, pancreatic and rectal cancers with a clinical impact in a significal proportion of patients. The metabolic activity, as recorded prior to any treatment, holds prognostic information in esophageal and rectal cancers, as well as GISTs. Methodological issues remain to be solved, but the potential is clearly present so that an increased clinical role is highly likely in the near future. FDG PET-CT is a major clinical tool in the detection and staging of recurrent colorectal cancer, and for determining the resectability of liver metastases. Ongoing developments include technological advances, in particular the combined PET-MR devices, and alternative tracers, such as those imaging angiogenesis. http://hdl.handle.net/2268/148010 Title: A propos d'un séminome médiastinal. <br/> <br/>Author, co-author: Gilis, F.; Massart, B.; LIFRANGE, Eric; Van Lancker, M. A.; Jardon-Jeghers, C.; Tjean, M.; Bury, J.; Boniver, Jacques http://hdl.handle.net/2268/148008 Title: Qu'attendre de l'échographie mammaire? <br/> <br/>Author, co-author: COLIN, Claude; LIFRANGE, Eric; EVRAUD, Ginette; CREVECOEUR, André http://hdl.handle.net/2268/148007 Title: Validation de la technique de biopsie du ganglion sentinelle dans le cancer du sein <br/> <br/>Author, co-author: Bleret, Valerie; Lifrange, Eric; Ghuysen, Vincent; Milet, J.; Fridman, Viviana; Colin, Claude <br/> <br/>Abstract: PURPOSE: Assessment of our experience and validation of the sentinel lymph node biopsy technique in breast cancer stage T0-T2N0M0 surgery. METHODS: Identification and biopsy of the sentinel lymph node by the radio colloid method in a consecutive series of 205 patients undergoing surgery for breast cancer stage T0-T2N0M0 between October 1998 and January 2007, initially in association with a complete axillary lymph node dissection (learning curve), later in an elective way. Prospective recording of the data and analysis with an average follow-up of 50 months (3 to 102 months). RESULTS: Biopsy rate of the sentinel lymph node of 90%, false negative rate of the method 2.5%, axillary recurrence rate 0%. CONCLUSION: We confirm in this series that the sentinel lymph node biopsy technique is a reliable approach in our experience for the evaluation of the axillary lymph node status in breast cancer stage T0-T2N0M0. http://hdl.handle.net/2268/147256 Title: Tachycardia during coronary computed tomography angiography. <br/> <br/>Author, co-author: Coolen, Tim; Ghekiere, Olivier; Djekic, Julien; Mancini, Isabelle; NCHIMI LONGANG, Alain http://hdl.handle.net/2268/146042 Title: New method for 3D reconstruction of the human cranial vault from CT-scan data <br/> <br/>Author, co-author: Laurent, Cédric; JOLIVET, Erwan; HODEL, Jérôme; DECQ, Philippe; SKALLI, Wafa <br/> <br/>Abstract: This study presents a new method for the 3D reconstruction of the human cranial vault from routine Computed Tomography (CT) data. The reconstruction method was based on the conceptualization of the shape of the cranial vault with a parametric description. An initialization was first realized with the identification of anatomical landmarks and contours on Digitally Reconstructed Radiographs (DRR) in order to obtain a pre-personalized reconstruction. Then an optimization of the reconstruction was performed to segment the internal and external surfaces of the cranial vault for thickness computation. The method was validated by comparing final reconstructions issued from our approach and from a manual sliceby- slice segmentation method on ten CT-scans. Errors were comparable to the CT image resolution, and less than 2 min were dedicated to the operatordependant marking step. The reconstruction of internal and external surfaces of the cranial vault allows quantifying and visualizing of thickness throughout the cranial vault. This thickness mapping is useful for clinical purposes as additional pre-surgical information. Moreover, this study constitutes a first step in the personalized characterization of skull resistance directly from routine exams. http://hdl.handle.net/2268/144402 Title: Automatic Synthesis of [18F]Altanserin, a Radiopharmaceutical for Positron Emission Tomographic Studies of the Serotonergic Type-2 Receptors <br/> <br/>Author, co-author: Monclus, Michel; Van Naemen, John; Mulleneers, Eric; Damhaut, Philippe; Luxen, André; Goldman, Serge <br/> <br/>Abstract: [18F]Altanserin is routinely used in several centers to study the serotonergic type-2 receptors (5HT2) with positron emission tomography (PET). An automatic production system allowing the preparation of multimillicurie amounts [>1.5 GBq (40 mCi) EOS, mean radiochemical yield 20 ± 6% EOB, specific activity >1 Ci/µmol Image] of this radiopharmaceutical within a synthesis time of 90 minutes (quality controls included) is described in this paper. The apparatus includes the recovery of the activity from the target, the preparation of the dried [18F]KF/kryptofix 2.2.2 complex, the labeling reaction using a microwave cavity, the Sep Pak and HPLC purification. A sterile, pyrogen-free and single use unit was also developed for the formulation of the injectable solution. This last part could be used for the formulation of many other radiopharmaceuticals.; [18F]altanserin; automatic synthesis; positron emission tomography; 5HT2 receptors http://hdl.handle.net/2268/144400 Title: PET radiopharmaceuticals in Europe : Current use and data relevant for the formulation of summaries of product characteristics (SPCs) <br/> <br/>Author, co-author: Meyer, G. J.; Waters, S. L.; Coenen, H. H.; Luxen, André; Maziere, B.; Langstrom, B. <br/> <br/>Abstract: The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task group for licensing PET radiopharmaceuticals; this group has surveyed the use of these compounds in Europe by a questionnaire. The number of PET centres that responded to the questionnaire was 26, which included more than 90% of the larger European PET centres. The survey showed that 2-[18F]fluoro-2-deoxyglucose is by far the most important PET radiopharmaceutical with more than 200 applications per week, followed by [15O]water, [15O]carbonmonoxide, [13N]ammonia, [11C]-l-methionine, andl-6-[18F]fluoro-DOPA. More than 25 other PET radiopharmaceuticals are in regular use, however, at rather low application frequencies. The data were used by the European Pharmacopoeia Commission for its priority rating for requesting the formulation of monographs. Since it is likely that group registrations will be issued by authorities for the PET radiopharmaceuticals, relevant data on toxicity and dosimetry for the formulation of summaries of product characteristics have been collected by the task group as well. <br/> <br/>Commentary: The original publication is available at www.springerlink.com/content/l38106n5p3732840/?p=7bffe241e7664598a4b2ec8b94ff925e&pi=0 http://hdl.handle.net/2268/143754 Title: Diagnostic des lésions mammaires non palpables: intérêt des biopsies à l'aiguille stéréoguidée <br/> <br/>Author, co-author: Colin, Claude; Lifrange, Eric; Lambotte, René http://hdl.handle.net/2268/143452 Title: Newer Methods for Improving Yield from FDG-PET Imaging for Accurate Staging, Determining Tumor Biology, and Assessing Prognosis <br/> <br/>Author, co-author: HUSTINX, Roland http://hdl.handle.net/2268/143451 Title: (111)Indium-oxine labelling for evaluating the homing process of autologous osteoblasts implanted percutaneously in atrophic nonunion fractures. <br/> <br/>Author, co-author: Hauzeur, Jean-Philippe; Bernard, Claire; Egrise, Dominique; Kurth, William; Van Cauwenberge, Henry; Lechanteur, Chantal; Gillet, Philippe; Beguin, Yves; MALAISE, Michel; HUSTINX, Roland <br/> <br/>Abstract: PURPOSE: The aim of the study was to control the in vivo localisation of implanted cells in cell-based therapies. Labelling cells with (111)indium-oxine is one of the most interesting methods proposed. We evaluated this method in the setting of autologous osteoblast implantation in nonunion fractures. METHODS: An in vitro study of osteoblasts was conducted after (111)indium-oxine labelling. Radioactivity retention and viability, proliferation and the ability to produce alkaline phosphatase were evaluated in a seven-day culture. In vivo labelling of implanted osteoblastic cells was conducted during a therapeutic trial of atrophic nonunion fractures, with the leakage outside the nonunion site and local uptake evolution at four, 24 and 48 hour being studied. RESULTS: The mean labelling efficiency for osteoprogenitors was 78.8 +/- 4.6 %. The intracellular retention was 89.4 +/- 2.1 % at three hours and 67.3 +/- 4.7 % at 18 hours. The viability assessed at three hours was 93.7 +/- 0.6 %. After seven days of culture, morphology and alkaline phosphatase staining were similar for both labelled and unlabelled control cells, although the proliferation rate was decreased in the labelled cells. Some local intraosseous leakage was observed in four of 17 cases. All patients showed uptake at the injection site, with four having no other uptake. Four patients showed additional uptake in the bladder, liver and spleen, while 11 patients had additional uptake in the lungs in addition to the bladder, liver and spleen. The activity ratios (injection site/body) were 48 +/- 28 % at four hours, 40 +/- 25 % at 24 hours and 35 +/- 25 % at 48 hours. After correcting for decay, the activity within the injection site was 82 +/- 15 % at 24 hours and 69 +/- 11 % at 48 hours compared with the activity measured at four hours. No relationship was found between uptake and radiological bone repair. CONCLUSIONS: The (111)indium-oxine labelling appears to be a good method for monitoring the behaviour of the osteoblastic cells after their implantation in atrophic nonunion fractures. http://hdl.handle.net/2268/143292 Title: Evaluation of DCE-MRI postprocessing techniques to assess metastatic bone marrow in patients with prostate cancer <br/> <br/>Author, co-author: Michoux, Nicolas; SIMONI, Paolo; Tombal, Bertrand; Peeters, Frank; Machiels, Jean-Pascal; Lecouvet, Frédéric http://hdl.handle.net/2268/142656 Title: Performance Measurements of the microPET FOCUS 120 for Iodine-124 Imaging <br/> <br/>Author, co-author: Taleb, Dounia; Bahri, Mohamed Ali; Seret, Alain <br/> <br/>Abstract: This study aimed to evaluate the performance of the microPET FOCUS 120 for 124I in terms of counting rate capability and image quality using the NEMA NU 4-2008 methodology. Scanner sensitivity was measured for 124I for comparison and reached 75 cps/kBq, respectively, with the usual 350-650 keV energy window (EW) and 6 ns time window (TW). The noise equivalent count rate (NECR) index was defined as: NECR = RT2/(RP+RGP) (T = true, P = prompt, GP = γ-prompt). A rat phantom maximum NECR of 48 kcps was obtained for the 250-590 keV EW with 6 ns TW. An almost identical maximum NECR of 43 kcps was recorded for 350-590 and 350-650 keV EW and 6 ns TW. The 2 ns TW reduced the sensitivity and NECR by 40-50% for all EW. The mouse phantom NECR study was limited because of the maximum available activity concentration of 124I. The 250-590 keV EW showed the largest scatter and γ-prompt plus scatter fractions with 25.7% and 43%, respectively, for the rat phantom and 12.2% and 27% for the mouse phantom. With the 350-590 keV EW, these fractions decreased to 20% and 33.5% for the rat phantom and to 10% and 21% for the mouse phantom. The image quality was investigated with the NEMA NU 4-2008 dedicated phantom for four (two analytic and two iterative) 2D or 3D reconstruction methods. The lowest spillover ratios (SOR) for the phantom non-emitting regions were obtained for the 350-590 and 350-650 keV EWs. Recovery coefficients (RC) of the hot rods were the highest for the 350-590 keV EW except for the 1 mm rod. Scatter correction led to a large decrease in RC. The combination of the 350-590 keV EW with 6 ns TW appeared to be a good compromise between counting rate capability and image quality for the FOCUS 120, especially when maximum a posteriori reconstruction was used without scatter correction. Moreover this combination enabled the best quantification with an error as low as 0.36%. http://hdl.handle.net/2268/142339 Title: A propos des prothèses mammaires. L'examen senologique conventionnel <br/> <br/>Author, co-author: Lifrange, Eric; Colin, Claude http://hdl.handle.net/2268/142338 Title: En Bloc Excision of Nonpalpable Breast Lesions Using the Advanced Breast Biopsy Instrumentation System: An Alternative to Needle Guided Surgery? <br/> <br/>Author, co-author: Lifrange, Eric; Dondelinger, R. F.; Fridman, Viviana; Colin, Claude <br/> <br/>Abstract: This study was prospectively conducted to evaluate the clinical potential of the advanced breast biopsy instrumentation (ABBI) system as an alternative to needle localization and open surgery in the management of nonpalpable breast lesions (NPBL). One hundred and eighty-six consecutive patients were referred for management of NPBL. Thirty-six underwent an ABBI procedure, offered as a first step before possible surgery for lesions which would in any case have required complete excision. The 18 patients with a malignant ABBI biopsy underwent re-excision of the biopsy site and axillary dissection was carried out in cases of infiltrating carcinoma. The other 150 patients underwent image-guided needle biopsy. Following these procedures, 60/150 (40%) patients underwent needle-guided surgery. Finally, 96/186 (51%) patients required complete excision. A total of 43 benign lesions and 53 carcinomas were confirmed. Thirty-six out of 96 (38%) excisions were obtained with the ABBI system; 17/43 (40%) benign lesions and 11/53 (21%) carcinomas were completely removed with the ABBI system. Out of 9 malignant specimens with a pathological size less than 10 mm, 5/9 (55%) had tumor-free margins and in 8/9 (89%) no residual disease was found at re-excision. The preliminary results of this study suggest that, in selected cases, en bloc excision using the ABBI procedure could be an alternative to conventional surgery. http://hdl.handle.net/2268/140523 Title: ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. <br/> <br/>Author, co-author: McMurray, John J. V.; Adamopoulos, Stamatis; Anker, Stefan D.; Auricchio, Angelo; Bohm, Michael; Dickstein, Kenneth; Falk, Volkmar; Filippatos, Gerasimos; Fonseca, Candida; Gomez-Sanchez, Miguel Angel; Jaarsma, Tiny; Kober, Lars; Lip, Gregory Y. H.; Maggioni, Aldo Pietro; Parkhomenko, Alexander; Pieske, Burkert M.; Popescu, Bogdan A.; Ronnevik, Per K.; Rutten, Frans H.; Schwitter, Juerg; Seferovic, Petar; Stepinska, Janina; Trindade, Pedro T.; Voors, Adriaan A.; Zannad, Faiez; Zeiher, Andreas; Bax, Jeroen J.; Baumgartner, Helmut; Ceconi, Claudio; Dean, Veronica; Deaton, Christi; Fagard, Robert; Funck-Brentano, Christian; Hasdai, David; Hoes, Arno; Kirchhof, Paulus; Knuuti, Juhani; Kolh, Philippe; McDonagh, Theresa; Moulin, Cyril; Popescu, Bogdan A.; Reiner, Zeljko; Sechtem, Udo; Sirnes, Per Anton; Tendera, Michal; Torbicki, Adam; Vahanian, Alec; Windecker, Stephan; Sechtem, Udo; Bonet, Luis Almenar; Avraamides, Panayiotis; Ben Lamin, Hisham A.; Brignole, Michele; Coca, Antonio; Cowburn, Peter; Dargie, Henry; Elliott, Perry; Flachskampf, Frank Arnold; Guida, Guido Francesco; Hardman, Suzanna; Iung, Bernard; Merkely, Bela; Mueller, Christian; Nanas, John N.; Nielsen, Olav Wendelboe; Orn, Stein; Parissis, John T.; Ponikowski, Piotr http://hdl.handle.net/2268/140522 Title: ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. <br/> <br/>Author, co-author: McMurray, John J. V.; Adamopoulos, Stamatis; Anker, Stefan D.; Auricchio, Angelo; Bohm, Michael; Dickstein, Kenneth; Falk, Volkmar; Filippatos, Gerasimos; Fonseca, Candida; Gomez-Sanchez, Miguel Angel; Jaarsma, Tiny; Kober, Lars; Lip, Gregory Y. H.; Maggioni, Aldo Pietro; Parkhomenko, Alexander; Pieske, Burkert M.; Popescu, Bogdan A.; Ronnevik, Per K.; Rutten, Frans H.; Schwitter, Juerg; Seferovic, Petar; Stepinska, Janina; Trindade, Pedro T.; Voors, Adriaan A.; Zannad, Faiez; Zeiher, Andreas; Kolh, Philippe http://hdl.handle.net/2268/138616 Title: Sleep stabilizes visuomotor adaptation memory : an fMRI study <br/> <br/>Author, co-author: Albouy, Geneviève; Vandewalle, Gilles; Sterpenich, Virginie; Rauchs, Géraldine; Desseilles, Martin; Balteau, Evelyne; Degueldre, Christian; Phillips, Christophe; Luxen, André; Maquet, Pierre http://hdl.handle.net/2268/137724 Title: A robust automated shimming procedure for breast MR spectroscopy <br/> <br/>Author, co-author: Balteau, Evelyne; Charles-Edwards, GD http://hdl.handle.net/2268/137723 Title: A shimming procedure for fMRI, optimizing the local BOLD sensitivity <br/> <br/>Author, co-author: Balteau, Evelyne; Weiskopf, Nikolaus