http://hdl.handle.net/2268/101 Search this channel search http://orbi.ulg.ac.be/simple-search http://hdl.handle.net/2268/148448 Title: How to define responders in osteoarthritis <br/> <br/>Author, co-author: Cooper, Cyrus; Adachi, Jonathan D; Bardin, Thomas; Berenbaum, Francis; Flamion, Bruno; Jonsson, Helgi; Kanis, John A; Pelousse, Franz; Lems, Willem F; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne; Reiter, Susanne; Reginster, Jean-Yves; Rizzoli, René; Bruyère, Olivier <br/> <br/>Abstract: Background: Osteoarthritis is a clinical syndrome of failure of the joint accompanied by varying degrees of joint pain, functional limitation, and reduced quality of life due to deterioration of articular cartilage and involvement of other joint structures. Scope: Regulatory agencies require relevant clinical benefit on symptoms and structure modification for registration of a new therapy as a disease-modifying osteoarthritis drug (DMOAD). An international Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and International Osteoporosis Foundation was convened to explore the current burden of osteoarthritis, review current regulatory guidelines for the conduct of clinical trials, and examine the concept of responder analyses for improving drug evaluation in osteoarthritis. Findings: The ESCEO considers that the major challenges in DMOAD development are the absence of a precise definition of the disease, particularly in the early stages, and the lack of consensus on how to detect structural changes and link them to clinically meaningful endpoints. Responder criteria should help identify progression of disease and be clinically meaningful. The ideal criterion should be sensitive to change over time and should predict disease progression and outcomes such as joint replacement. Conclusion: The ESCEO considers that, for knee osteoarthritis, clinical trial data indicate that radiographic joint space narrowing40.5mm over 2 or 3 years might be a reliable surrogate measure for total joint replacement. On-going research using techniques such as magnetic resonance imaging and biochemical markers may allow the identification of these patients earlier in the disease process http://hdl.handle.net/2268/148171 Title: Traitement de suppléance de l'insuffisance rénale terminale : aspects éthiques et économiques, rôles du médecin généraliste <br/> <br/>Author, co-author: BOVY, Christophe; Crismer, André; KRZESINSKI, Jean-Marie http://hdl.handle.net/2268/147562 Title: Equivalence of a single dose (1200mg) compared to a 3-time a day dose (400mg) of chondroitin 4&6 sulfate in patients with knee osteoarthritis: Results of a randomized double blind placebo controlled study <br/> <br/>Author, co-author: Zegels, Brigitte; LEONORI, Lorenzo; Crozes, P; Uebelhart, D; Bruyère, Olivier; Reginster, Jean-Yves http://hdl.handle.net/2268/147554 Title: Reproducibility of joint space width assessment when external calibration on the radiograph is missing <br/> <br/>Author, co-author: DEROISY, Rita; Reginster, Jean-Yves; Bruyère, Olivier http://hdl.handle.net/2268/147553 Title: Validity of the French hip and knee replacement expectations surveys <br/> <br/>Author, co-author: NEUPREZ, Audrey; François, Garance; Delcour, JP; Fatemi, F; Bruyère, Olivier; Gosset, Christiane; Mancuso, C; Gillet, Philippe; Reginster, Jean-Yves http://hdl.handle.net/2268/147550 Title: Evaluation of the impact of a 6-month training by whole body vibration on the risk of falls among nursing home residents <br/> <br/>Author, co-author: Beaudart, Charlotte; Buckinx, Fanny; Demonceau, Marie; Maquet, Didier; Crielaard, Jean-Michel; Reginster, Jean-Yves; Bruyère, Olivier http://hdl.handle.net/2268/147547 Title: Clinical characteristics of patients responsive to whole body vibration <br/> <br/>Author, co-author: Beaudart, Charlotte; Buckinx, Fanny; Maquet, Didier; Crielaard, Jean-Michel; Reginster, Jean-Yves; Bruyère, Olivier http://hdl.handle.net/2268/147540 Title: Quantitative gait assessment using an accelerometer technology as a predictive tool of falls among nursing home residents: a 6-month prospective study <br/> <br/>Author, co-author: Bruyère, Olivier; Detalle, Anne-Sophie; Demonceau, Marie; Beaudart, Charlotte; Croisier, Jean-Louis; Crielaard, Jean-Michel; Reginster, Jean-Yves; Maquet, Didier http://hdl.handle.net/2268/147537 Title: Changes in the structure and the symptoms of the osteoarthritis knee and prediction of future knee replacement over an 8-year follow-up period <br/> <br/>Author, co-author: Bruyère, Olivier; Cooper, Cyrus; Pavelka, Karel; Rabenda, Véronique; Buckinx, Fanny; Beaudart, Charlotte; Reginster, Jean-Yves http://hdl.handle.net/2268/147534 Title: Cost-effectiveness of vitamin D and calcium supplementation in the treatment of postmenopausal women <br/> <br/>Author, co-author: Hiligsmann, Mickaël; Ben Sedrine, Wafa; Rabenda, Véronique; Bruyère, Olivier; Reginster, Jean-Yves http://hdl.handle.net/2268/147529 Title: What is the predictive value of MRI for the occurrence of hard clinical endpoints in knee osteoarthritis? <br/> <br/>Author, co-author: Pelletier, Jean-Pierre; Peterfy, Charles; Brandi, Maria Luisa; Bruyère, Olivier; Chapurlat, Roland; Cicuttini, Flavia; Conaghan, P; Doherty, M; Genant, Harry K; Guermazi, A; Hochberg, Mark; Hunter, D; Kanis, John A; Kloppenburg, Margreet; Laredo, JD; Martel-Pelletier, Johanne; McAlindon, T; Nevitt, M; Raynauld, Jean-Pierre; Rizzoli, René; Zilkens, C; Reginster, Jean-Yves; Cooper, Cyrus http://hdl.handle.net/2268/147527 Title: Role of nutraceuticals in the symptomatic and structural management of osteoarthritis <br/> <br/>Author, co-author: Bruyère, Olivier http://hdl.handle.net/2268/147526 Title: Health economics in osteoarthritis <br/> <br/>Author, co-author: Hiligsmann, Mickaël; Cooper, Cyrus; Arden, Nigel; Boers, Marteen; Branco, Jaime; Brandi, Maria Luisa; Bruyère, Olivier; Guillemin, Francis; Hochberg, Marc; Hunter, David; Kanis, John A; Kvien, Tore; Laslop, Andrea; Petit-Dop, Florence; Pelletier, Jean-Pierre; Pinto, Daniel; Reiter, Susanne; Rizzoli, René; Rovati, Lucio C; Severens, Hans; Silverman, Stuart; Tsouderos, Yannis; Tugwell, Peter; Reginster, Jean-Yves http://hdl.handle.net/2268/147522 Title: What is the value of biomarkers for drug development in osteoarthritis? <br/> <br/>Author, co-author: Lotz, Martin; Martel-Pelletier, Johanne; Christiansen, Claus; Berenbaum, Francis; Brandi, Maria Luisa; Bruyère, Olivier; Chapurlat, Roland; COLLETTE, Julien; Cooper, Cyrus; Heinegard, Dick; Kanis, John A; Kraus, V; Laslop, Andrea; Lems, Willem; Lohmander, S; Meulenbelt, I; Pelletier, Jean-Pierre; Raynauld, Jean-Pierre; Reiter, Susan; Rizzoli, René; Sandel, L; Spector, Tim; Van Spil, Willem E; Reginster, Jean-Yves http://hdl.handle.net/2268/147521 Title: Quality of life in sarcopenia and frailty <br/> <br/>Author, co-author: Rizzoli, René; Reginster, Jean-Yves; Arnal, Jean-François; Bautmans, Ivan; Bischoff-Ferrari, Heike; Biver, Emmanuel; Boonen, Steven; Brandi, Maria Luisa; Chines, Arkadi; Cooper, Cyrus; Dahlin-Ivanoff, Synneve; Epstein, Sol; Kanis, John A; Fielding, Roger A; Goodpaster, Bret; Laslop, Andrea; Malafarina, Vincenzo; Rodriguez Mañas, Leocadio; Mitlak, Bruce; Oreffo, Richard O; Petermans, Jean; Reid, Kieran; Roland, Yves; Sayer, Avan Aihie; Tsouderos, Yannis; Visser, Marjolein; Bruyère, Olivier http://hdl.handle.net/2268/147520 Title: Nonpharmacological management <br/> <br/>Author, co-author: Bruyère, Olivier http://hdl.handle.net/2268/147518 Title: Strontium ranelate improves osteoarthritis symptoms compared to placebo in patients with knee OA: The SEKOIA study <br/> <br/>Author, co-author: Bruyère, Olivier; Richette, P; Bellamy, N; Brown, JP; Chapurlat, R; Chevalier, X; Czerwinski, E; Devogelaer, JP; March, L; Pavelka, K; Punzi, L; Cooper, C; Reginster, Jean-Yves http://hdl.handle.net/2268/147508 Title: Le cas clinique du mois. Intoxication aigue au methanol <br/> <br/>Author, co-author: Brasseur, Edmond; Lemineur, T.; Leonard, Philippe; Richardy, M.; Lambermont, Bernard <br/> <br/>Abstract: We report a fatal methanol intoxication and discuss its physiopathology, diagnosis and treatment. http://hdl.handle.net/2268/147336 Title: Sodium monofluorophosphate reduces fracture incidence in women with postmenopausal osteoporosis : a randomized, placebo-controlled, double-blind study <br/> <br/>Author, co-author: Meurmans, L; Zegels, Brigitte; Rovati, LC; Taquet, AN; Reginster, Jean-Yves http://hdl.handle.net/2268/147334 Title: Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, prostaglandin E2, proteoglycans and cytokines production by human articular chondrocytes <br/> <br/>Author, co-author: Henrotin, Yves; Labasse, A; Zheng, SX; De Groote, D; Jaspar, JM; Guillou, B; Reginster, Jean-Yves