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See detailMechanical properties, residual stresses and structural behavior of thin-walled stainless steel profiles
Rossi, Barbara ULg

Doctoral thesis (2008)

Although it offers a wide variety of interesting properties such as fire resistance or durability, stainless steel has been used in limited amount in structures. It is a known fact that the design rules ... [more ▼]

Although it offers a wide variety of interesting properties such as fire resistance or durability, stainless steel has been used in limited amount in structures. It is a known fact that the design rules don't properly account for the additional benefits of stainless steel properties and are largely based on the specifications for carbon steel. Indeed, a number of similarities exist between stainless steel and ordinary carbon steel but there is sufficient differences to afford a specific treatment in design standards. And since stainless steel is an expensive material, it is important to accurately predict the resistance of structural members. The present research work is dedicated to the study of cold-formed stainless steel profiles. It actually follows the life of a stainless steel construction element and falls on three fundamental topics: the material behavior, the through-thickness residual stress distribution and mechanical enhancement due to the cold-forming process and, last, the strength of concentrically compressed thin-walled columns. Firstly, several constitutive models are characterized such as Teodosiu-Hu's micro-structural based hardening model, capable of predicting the behavior of the studied stainless steel grade submitted to biaxial loading causing plastic strain. This model accounts for the nonlinear hardening behavior, the anisotropy, the Bauschinger effect and more complex behavior such as the observed work-hardening stagnation under reversed deformation at large strains. For this purpose, a collection of tests is carried out including multiaxial tests such as tensile-shear tests and successive simple shear tests and plane-strain tests. Secondly, the effects of the forming process on the mechanical properties are studied. To begin with, on the basis of the constitutive models developed previously, an analytical method that calculates the biaxial residual stress distribution in the walls and in the corners of cold-formed profiles is established. Based on the conclusions drawn from this theoretical analysis, a new formula for the evaluation of the actual mechanical properties is established. This formula is not restricted to a single alloy or type of cross-section. Current design standards are then used to calculate the strength of lipped-channel section columns failing by combined distortional and overall flexural-torsional buckling and the results are compared to tests. Indeed, full-scale tests on cold-formed stainless steel lipped channel section columns were achieved in the Structures Laboratory of the University of Liège. And, once verified against the test results, finite element models were used to generate additional results when necessary. The author then presents a new Direct Strength Method taking into account this phenomenon. Finally, a wide amount of reference results are gathered from the literature, without limiting oneself to any kind of cross-section or stainless steel grade. This database is used to propose an improved formulation for the design of stainless steel thin-walled section columns failing by distortion, local or combination of local and overall buckling in the low slenderness range. [less ▲]

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See detailImplantation d'acide hyaluronique estérifié lors de la microchirurgie des lésions cordales bénignes
FINCK, Camille ULg

Doctoral thesis (2008)

La microchirurgie des pathologies cordales bénignes est pratiquée afin d’améliorer les caractéristiques mécaniques du vibrateur laryngé. C’est en augmentant la souplesse tissulaire et la fermeture ... [more ▼]

La microchirurgie des pathologies cordales bénignes est pratiquée afin d’améliorer les caractéristiques mécaniques du vibrateur laryngé. C’est en augmentant la souplesse tissulaire et la fermeture glottique en phonation que le micro-chirurgien espère améliorer les caractéristiques du son laryngé émis. Les techniques microchirurgicales ont évolué de manière spectaculaire au cours des 20 dernières années grâce à la connaissance de plus en plus approfondie de la structure cordale normale et surtout de son tissu conjonctif : la lamina propria. C’est la partie la plus superficielle de la lamina propria, l’espace de Reinke, qui joue le rôle le plus important dans la production du son. C’est aussi l’espace de Reinke qui est occupé, détruit ou remanié en cas de pathologie cordale bénigne. La microchirurgie vise à le libérer du processus pathologique. L’originalité des techniques microchirurgicales exposées dans ce travail est de tenter, non seulement de libérer l’espace vibrant de la lésion cordale, mais aussi de modifier les processus cicatriciels post-opératoires par l’utilisation d’un implant résorbable d’acide hyaluronique estérifié. Les objectifs de ce travail sont : - de contribuer à la connaissance des résultats fonctionnels laryngés et vocaux observés après une microchirurgie cordale - d’évaluer l’impact fonctionnel, sur ces résultats, de l’utilisation d’un implant résorbable d’acide hyaluronique estérifié, en fin d’intervention chirurgicale. [less ▲]

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See detailSystematic Cooperation in P2P Grids
Briquet, Cyril ULg

Doctoral thesis (2008)

P2P Grid computing seeks the convergence of Grid and P2P technologies. Deploying a P2P Grid middleware on a set of computers enables an organization to automatically barter computing time with other ... [more ▼]

P2P Grid computing seeks the convergence of Grid and P2P technologies. Deploying a P2P Grid middleware on a set of computers enables an organization to automatically barter computing time with other Internet-connected organizations. Such P2P exchanges of computing time enable individual Peers, i.e. organizations, to transparently aggregate large amounts of computational power with minimal infrastructure requirements or administrative cost. Challenges arise from the requirement for scalability and robustness. Individual worker nodes are unreliable, as P2P Grids operate on unmanaged desktop computers. A specificity of P2P Grids is that each Peer can reclaim at any time the computational power of worker nodes supplied to other Peers, leading to bursts of execution preemption. These are the major contributions of our dissertation: * Firstly, we propose a new P2P Grid architecture, the Lightweight Bartering Grid (LBG). Through systematic cooperation between Grid nodes, the reliability of execution of computational requests is greater than the sum of the reliabilities of worker nodes. * Secondly, we propose a highly scalable data transfer architecture. It is based both on the BitTorrent P2P file sharing protocol and on the removal of the temporal cost of downloading redundant copies of input data files. * Thirdly, besides a middleware implementation of LBG, we also provide an implementation of a discrete-event simulator. Its originality resides in the weaving of the simulator code into the bartering code of the middleware, which is made possible through the virtualization of Grid nodes. This enables reproducible testing and accurate performance evaluation of the bartering policies because the Peers of a simulated Grid make the same bartering decisions as Peers deployed on real computers. The LBG architecture exhibits the following remarkable features: * The scheduling model supports the queueing of external requests and the architecture enables a flexible study of bartering policies. * The architecture is open, flexible, lightweight and facilitates software engineering. It enables the easy development, testing, evaluation and deployment of combinations of scheduling policies. * The architecture is fully P2P. [less ▲]

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See detailEtudes génétiques et immunomodulatoires de la ghréline sur les traits de production et de conformation en races bovines ainsi que sur la croissance chez le rat
Colinet, Frédéric ULg

Doctoral thesis (2008)

En production animale, notamment dans les filières bovines, il est d’un intérêt économique d’augmenter la quantité d’hormone de croissance dans la circulation sanguine. La ghréline est un peptide ... [more ▼]

En production animale, notamment dans les filières bovines, il est d’un intérêt économique d’augmenter la quantité d’hormone de croissance dans la circulation sanguine. La ghréline est un peptide principalement produit au niveau de la paroi stomacale. Ce ligand endogène au GHSR stimule la sécrétion hypophysaire de l’hormone de croissance. Peptide orexigène, la ghréline est impliquée dans les mécanismes relatifs au maintien de l’homéostasie énergétique. Dans l’optique d’améliorer les performances animales, deux approches de la ghréline ont été effectuées. La première approche consiste en l’étude des gènes bovins codant pour la ghréline (bGHRL) et son récepteur (bGHSR). Ces deux gènes ont été respectivement localisés sur BTA 22 et BTA 1. Quatorze polymorphismes ont été détectés sur ces deux gènes et trois d’entre eux affectent la structure primaire du GHSR bovin. Des associations, à différents niveaux de signification, entre certains de ces 14 sites polymorphiques et des traits de production et de conformation ont été mis en évidence au sein d’un groupe de 127 taureaux Holstein sur base de leurs descendances directes présentes en Région Wallonne. La seconde approche aborde les effets d’une immunisation passive contre la ghréline sur des rats mâles en croissance en comparaison à celles contre la leptine et la cholécystokinine. Lors d’une alimentation équilibrée, le traitement envers la ghréline sur ces rats n’a pas influencé la croissance et l’ingestion par rapport aux animaux témoins. Des effets ont été observés entre les différentes immunomodulations au niveau des paramètres de croissance, d’ingestion et endocrinologiques. Les présents résultats invitent à de nouvelles investigations des gènes bGHRL et bGHSR sur des données relatives à d’autres populations/races bovines et de l’immunomodulation de la ghréline lors de conditions d’expérimentation différentes (alimentation déséquilibrée, stade physiologique, espèce, etc.). Ces investigations pourraient être valorisées en sélection et production animale mais également en médecine tant humaine que vétérinaire. [less ▲]

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See detailDesign, synthesis and biological evaluation of cognitive enhancers acting through the potentiation of the AMPA receptors
Francotte, Pierre ULg

Doctoral thesis (2008)

Alzheimer’s disease (AD) represents one of the greatest health problems in industrialized countries considering the ageing population. Only four drugs are currently approved for the treatment of this ... [more ▼]

Alzheimer’s disease (AD) represents one of the greatest health problems in industrialized countries considering the ageing population. Only four drugs are currently approved for the treatment of this disease. As these drugs are characterized with a limited time efficacy, it has become urgent to develop additional innovative AD treatments. Amongst the approaches that are actively investigated, the one consisting in potentiating a subclass of glutamate receptors appears attractive. This well advanced pharmacological approach includes three major classes of compounds amongst which appear the benzothiadiazine 1,1-dioxides. The present thesis is a pursuit of the preliminary efforts that were published in 1998 and 2001 by our team. Based on promising in vitro results obtained with the lead compound 59, pharmacomodulations around 59’s structure have been achieved in order to enhance its in vivo activity and to optimize its pharmacokinetic parameters. First efforts were devoted to exploratory synthesis where attention was paid to the impact of the substituent introduced at the 7-position. Moreover, some pyridothiadiazine dioxides as well as thienothiadiazine dioxides were prepared. The most important part of our pharmacomodulations was focused on the thiadiazine ring system. Considering that the poor in vivo results obtained with 59 could be due to a metabolic weakness of the latter, the introduction of fluorine atoms was tempted as a lead optimization strategy. This approach was successful, since it led to the synthesis of 95b which was selected for further pharmacological evaluations. This new lead compound was shown to exert significant cognitive-enhancing effects in vivo after oral administration to Wistar rats. Moreover, the study of the metabolic degradation of 95b allowed the assessment of the starting hypothesis that had dictated the pharmacomodulation’s philosophy. Finally, additional exploratory pharmacomodulations were achieved notably leading to the preparation of a quinazolinone series and 1,4-benzothiazine compounds. This research allowed to significantly improve the pharmacokinetic profile of our series and led to the identification of 95b as a new lead compound. However, many pharmacomodulations remain to be explored. The data collected during this thesis are appealing further studies. Efforts in the near future should lead to the design of novel drug candidates among which a future innovative AD treatment could emerge. [less ▲]

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See detailDesign of new stealthy and pH-sensitive polymer micelles for potential solid tumor targeting
Van Butsele, Kathy

Doctoral thesis (2008)

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See detailEtude des facteurs écologiques et écotoxicologiques impliqués dans la réussite d’incubation chez la tortue luth, Dermochelys coriacea, de Guyane Française
Guirlet, Elodie ULg

Doctoral thesis (2008)

Leatherback turtles, Dermochelys coriacea, have relatively low hatching success in comparison to other marine turtle species. This low hatching rate is largely a result of high embryonic mortality rather ... [more ▼]

Leatherback turtles, Dermochelys coriacea, have relatively low hatching success in comparison to other marine turtle species. This low hatching rate is largely a result of high embryonic mortality rather than infertility, but the specific causes remain unknown. Leatherbacks are vulnerable to excessive adult mortality (resulting in population decline) because they are long-lived species. However, low hatching success and corresponding low juvenile recruitment could also result in long term declines of leatherbacks. On the Yalimapo beach, in French Guiana, hatching success is lower for this species than on other nesting sites, emphasising the problem of recruitment for the population. Understanding the causes of low hatching success is therefore an important conservation step towards preventing extinction in this population. During my thesis, I investigated the role of ecological (predation and nest site location) and ecotoxicological factors (blood and egg contamination by trace elements and organochlorine compounds) on the hatching success of leatherback nests. Firstly, nest location was shown to have an important effect on predation and inundation rate that decreased hatching success. Secondly, a maternal transfer of contaminants from females to their eggs was confirmed, raising the issue of the deleterious effects of environmental contaminants on embryos development, a developmental stage very sensitive to contaminants. Dose-effect relationships between contaminants and hatching success need to be assessed to establish the risk of environmental pollution for leatherback reproduction. Moreover, the use of stable isotope analysis for females differing in the number of years between two reproductive seasons revealed that they used different feeding areas. These feeding grounds differed in their geographical location, but also in the quality of the available prey in terms of their level of contamination by environmental pollutants, highlighting the issue of adult contamination. This thesis confirmed the importance of ecological factors for hatching rate and highlighted the existence of ecotoxicological factors, which have not yet been studied for the leatherback turtle. [less ▲]

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See detailPolitical Transnationalism and the State
Lafleur, Jean-Michel ULg

Doctoral thesis (2008)

The first part of the thesis consists in a review of the literature and a conceptual discussion about the concept of immigrant transnationalism and immigrant political transnationalism. This discussion ... [more ▼]

The first part of the thesis consists in a review of the literature and a conceptual discussion about the concept of immigrant transnationalism and immigrant political transnationalism. This discussion shows that a series of gaps currently exists in the research on the links between the emigrants and the home country. Two of such gaps are underlined in the thesis. On the one hand, it remains difficult to determine why states decide to extend political citizenship to their citizens abroad. On the other hand, the influence of the state on its emigrant community seems neglected for the benefit of a post-national vision of citizenship. These are the gaps that this thesis is trying to address. The second part of the thesis presents in three case studies the results of the empirical research conducted in Italy, Belgium and Mexico. Some elements of migration history introduce each case and is then followed by an extensive analysis of the debate on the extension of political citizenship (especially the right to vote from abroad). A special focus is put on the role of internal actors (political parties, administrations...) and external actors (migrants, associations...). In the third part of the thesis, the author conducts a comparative analysis of the three cases. By doing so, the reasons why states extend political citizenship to citizens residing abroad appears clearly. It also leads to reject the post-national vision of citizenship supported by some scholars. After the presentation of the four variables pushing to act as they do in the field of external political citizenship, the thesis concludes by opening up new research tracks in the field of political transnationalism. [less ▲]

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See detailHileôs tôi phorounti. Sérapis sur les gemmes et les bijoux antiques
Veymiers, Richard ULg

Doctoral thesis (2008)

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See detailDétection et caractérisation de peptides obliques au sein de protéines amyloïdogéniques
Crowet, Jean-Marc ULg

Doctoral thesis (2008)

The study of amyloidogenic proteins is of interest in biochemistry because these proteins undergo conformational changes and aggregation. Both processes are largely implicated in several diseases ... [more ▼]

The study of amyloidogenic proteins is of interest in biochemistry because these proteins undergo conformational changes and aggregation. Both processes are largely implicated in several diseases including Alzheimer’s, Parkinson’s or Creutzfeldt-Jakob’s disease. These phenomena are not completely understood, either at a structural or energetical point of view. Tilted peptides are short protein fragment (11 to 19 residues) that adopt a tilted orientation when inserted into biological membranes and destabilise them. Recently, tilted peptides have been detected in two amyloidogenic proteins involved in neurodegenerative diseases; the amyloid β peptide responsible for Alzheimer’s disease, and the PrP protein that causes Creutzfeldt-Jakob’s disease. Tilted peptides could be responsible for the neurotoxic effects of these proteins. Due to their destabilising properties, they could interact directly with the membrane leading to cell death. Tilted peptides could also be involved in the transconformational process of the proteins. The aim of this work is to detect tilted fragments in other amyloidogenic proteins by molecular modelling and to study some of these peptides experimentally to evidence their lipid destabilizing properties, their structure and their toxicity. In addition, this work enable the design of an automatic method of detection for tilted peptides. Twenty-two tilted peptides from 18 different proteins have been detected among 53 amyloidogenic proteins and 7 peptides were tested experimentally. The results support the hypothesis that some tilted peptides could be involved in transconformational processes and/or cytotoxicity related to amyloidogenic proteins. [less ▲]

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See detailUne rhétorique par objet: les mimétismes chez Francis Ponge
Demoulin, Laurent ULg

Doctoral thesis (2008)

Les recueils de Francis Ponge Le Parti pris des choses et Pièces sont analysés poème par poème à la recherche de mimétismes, c'est-à-dire des "procédés stylistiques de formes variables visant à minimiser ... [more ▼]

Les recueils de Francis Ponge Le Parti pris des choses et Pièces sont analysés poème par poème à la recherche de mimétismes, c'est-à-dire des "procédés stylistiques de formes variables visant à minimiser l'arbitraire du signe, c'est-à-dire à motiver quelque peu le langage en établissant un mien entre la forme du plan du contenu et celle du plan de l'expression". [less ▲]

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See detailStudy of Genetic Variability of Fatty Acid Profile in Bovine Milk and Fat Using Mid-Infrared Spectrometry
Soyeurt, Hélène ULg

Doctoral thesis (2008)

Changes in milk fat composition influence its nutritional quality as well as the technological properties of butter. The impact of feed on fat composition is well known; however, limited information is ... [more ▼]

Changes in milk fat composition influence its nutritional quality as well as the technological properties of butter. The impact of feed on fat composition is well known; however, limited information is available on the genetic variability of fatty acids in bovine milk. The overall aim of this PhD thesis was to study the genetic variability of fatty acid profile in bovine milk and fat. This type of research needs a large amount of data. Expensive reference analysis is used to measure the fatty acid contents in fat. The first objective of this thesis was to develop an alternative method that could be faster and cheaper than traditional methods. Calibration equations predicting the contents of fatty acid from mid-infrared spectrum were established. The contents of saturated and monounsaturated fatty acids, omega-9, fatty acids with short, medium and long chain were the best predicted. Thanks to the implementation of this method in the Walloon routine milk recording, more than 20,000 milk samples were analyzed. This database permitted to model the variation of fatty acid contents in milk and fat. From these models, the genetic variability of fatty acid profile was shown. The complexity of models increased throughout this project due to the increase of new available data. Differences across 7 dairy breeds were estimated using single and multi-trait mixed models. Milk fat and delta-9 desaturase activity of Jersey and dual purpose Belgian Blue differed significantly from Holsteins. Therefore, the choice of a given breed could modify the fat composition. Heritability values obtained for studied fatty acids with multi-trait mixed model ranged from 0.05 to 0.42. Higher values were observed for saturated compared to unsaturated fatty acids. Moderate heritability estimates were observed for the activity of delta-9 desaturase (0.20) and the hardness of butter (0.27). These two traits were estimated by specific fatty acid ratios. The heritability observed using a multi-trait random regressions test day model for the content of saturated fatty acids (0.42) was similar to the one observed for the percentage of fat (0.37). Considering the impact of selection on fat content, the selection could have a great impact on fat composition. High genetic correlations were observed between some fatty acids having similarities in their synthesis. Heritability and correlations varied through the duration of the lactation. Due to the large number of fatty acids, the estimation of an index, which includes the proper fatty acid profile, could be interesting for a future selection program. This PhD thesis provides the background required by future studies to estimate the impact of animal selection on milkfat composition. [less ▲]

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See detailLa transmission du patrimoine culturel immatériel : réflexion sur l'importance d'une médiation culturelle
Lempereur, Françoise ULg

Doctoral thesis (2008)

By signing the UNESCO Convention for the Safeguarding of Intangible Cultural Heritage , each State Party committed itself to take the necessary measures to ensure the viability of oral traditions ... [more ▼]

By signing the UNESCO Convention for the Safeguarding of Intangible Cultural Heritage , each State Party committed itself to take the necessary measures to ensure the viability of oral traditions, performing arts, social practices, traditional knowledge & craftsmanship, and everything which should be transmitted as such or as an addition to natural, movable or real-estate heritages present within its territory. In the Convention, “Safeguarding” means “measures aimed at ensuring the viability of the intangible cultural heritage, including the identification, documentation, research, preservation, protection, promotion, enhancement, transmission, particularly through formal and non-formal education, as well as the revitalization of the various aspects of such heritage”. To ensure identification with a view to safeguarding, each State Party should draw up, in a manner geared to its own situation, one or more inventories of the intangible cultural heritage present in its territory. As no general theoretical studies exist on the validity of inventory and safeguarding, this dissertation progressed into a discussion about the issues, conditions and practices of transmission. Various interdisciplinary approaches – anthropological, historical, sociological, ethical, political and even sometimes linguistical, musicological, medical or juridical – resulted in blended viewpoints. The research is as theoretical as it is pragmatical. It comes after thirty years of pratical experience and observations, of filming and recording the oral and non-verbal traditions in the small communities of Wallonia, as well as experiences elsewhere. The author's basic assumption is that the existence of an intangible cultural heritage specific to each sociocultural community (of any size or composition) which, inspite of the threat of cultural globalization, allows this community to socialize, instead of cutting it off from the others. To highlight this heritage does not mean to withdraw into oneself or one’s past but to make way for cultural diversity, without ranking. This dissertation does not claim to solve, in 415 pages, all the theoretical problems raised by transmission and safeguarding of intangible cultural heritage. It suggests a first reflection about the contents, the aims, the means of transmission and the useful mediators for sustaining cultural diversity. It shows that the permanent evolution of the patrimonial values results from the social and economic situations where they are found and that it is pointless to supervise the transmission if holders of the heritage do not themselves support, consciously or not, the transmission process. [less ▲]

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See detailContribution à l'étude pharmacologique et clinique du tiludronate chez le cheval
Delguste, Catherine ULg

Doctoral thesis (2008)

Le tiludronate (Tildren™, CEVA Santé Animale, Libourne, France) est un bisphosphonate récemment introduit sur le marché dans plusieurs pays européens pour le traitement du syndrome podotrochléaire ... [more ▼]

Le tiludronate (Tildren™, CEVA Santé Animale, Libourne, France) est un bisphosphonate récemment introduit sur le marché dans plusieurs pays européens pour le traitement du syndrome podotrochléaire (syndrome naviculaire) et de l’ostéoarthrose des articulations intertarsienne distale et tarso-métatarsienne (éparvin) chez le cheval. Il est le premier bisphosphonate disponible en médecine vétérinaire en général, et en médecine équine en particulier. La posologie de tiludronate qui a fait l’objet d’un enregistrement dans différents pays d’Europe est de 10 administrations quotidiennes consécutives de 0.1 mg/kg sous forme de bolus intraveineux. Or, il ressort de la pratique courante que l’administration de la dose totale de 1 mg/kg en une perfusion lente unique est préférée par les utilisateurs pour des raisons pratiques et financières. Il ressort aussi de différentes études que cette forme d’administration est bien tolérée (Varela et al., 2002) et efficace dans certaines pathologies (Coudry et al., 2007). La première étude de ce travail a consisté en la comparaison pharmacologique de ces deux schémas posologiques. Il en est ressorti qu’ils produisaient une même exposition plasmatique totale et des effets similaires sur le marqueur plasmatique de résorption osseuse carboxy-télopeptide de collagène de type I (CTX-1). Il en a été conclu que les dix administrations quotidiennes consécutives de 0.1 mg/kg pouvaient être remplacées par la perfusion intraveineuse lente unique de 1 mg/kg. Les bisphosphonates sont caractérisés par des propriétés pharmacologiques très spécifiques et inhabituelles, de par leur forte affinité pour l’os et leur stockage à long terme dans ce compartiment profond. De ce fait, les modèles PK-PD classiques qui mettent en relation mathématique les concentrations plasmatiques avec les effets du médicament sont inadaptés pour décrire le comportement pharmacologique des bisphosphonates, et il est suggéré que les concentrations osseuses doivent être davantage prises en compte pour le développement de tels modèles (Cremers et al., 2005). Dans le but final de développer un modèle PK-PD du tiludronate chez le cheval, une méthode de biopsie osseuse permettant la répétition de dosages de tiludronate osseux a été validée dans la seconde étude de cette thèse. Dans celle-ci, huit chevaux ont subi des biopsies osseuses bilatéralement en quatre sites (le tuber coxae, le métacarpien principal, la 13ème côte et l’os cuboïde) à différentes échéances s’étalant de 1 jour à 1 an après 1 (n=4) ou 2 (n=4, à 4 semaines d’intervalle) traitements au tiludronate de 1 mg/kg par voie intraveineuse. En chaque site, les biopsies osseuses ont été effectuées à la fois à l’aide d’une fraise électrique de 5 mm de diamètre interne (Implanteo™, Anthogyr) pour l’échantillon test et d’un ostéotome ou d’une scie oscillante pour les échantillons de référence. Le tuber coxae s’est avéré être le meilleur site de biopsie, à la fois accessible, facile à biopsier, et sur lequel les dosages de tiludronate ne présentaient pas de difficultés techniques et étaient fiables. Malheureusement, ces biopsies n’offraient pas un matériel qualitativement et quantitativement suffisant que pour permettre des analyses histologiques et histomorphométriques. Dans une troisième étude, a donc été testée sur quatre chevaux la validité pour ce type d’analyses d’une autre technique de biopsies, utilisant un plus grand trocart que dans l’étude 2 (15 versus 5 mm de diamètre interne), et de type manuel. Les biopsies ont été réalisées sur cheval debout au niveau du tuber coxae avant (côté gauche) et 48 h après (côté droit) l’administration d’une perfusion intraveineuse lente de 1 mg/kg de tiludronate. Les biopsies ainsi réalisées ont permis d’effectuer les analyses escomptées. Cependant, aucun effet précoce du traitement au tiludronate n’a pu être mis en évidence sur les paramètres histologiques et histomorphométriques étudiés. Aucun modèle expérimental équin relatif aux pathologies pour lesquelles le tiludronate a été enregistré n’existe. Or il est indispensable, pour mieux en cerner les propriétés pharmacologiques et les applications cliniques potentielles, de tester son efficacité en conditions standardisées. L’immobilisation d’un membre sous plâtre est connue pour induire de l’ostéopénie de non usage chez le cheval (Buckingham et Jeffcott, 1991; van Harreveld et al., 2002). Dans la quatrième étude de ce travail, l’efficacité clinique du tiludronate versus placebo a été testée dans les conditions standardisées d’un modèle équin d’ostéopénie induite par immobilisation sous plâtre d’un membre antérieur pendant 8 semaines. Seize chevaux ont ainsi été immobilisés, dont huit ont été traités au tiludronate 1 mg/kg en perfusion lente deux fois à quatre semaines d’intervalle, soit en début et à mi-immobilisation, et huit ont reçu un placebo. Après la période d’immobilisation, les chevaux ont été progressivement remobilisés pendant 4 semaines puis ont subi un entraînement standardisé pendant 8 semaines. Le traitement au tiludronate a permis de prévenir la chute significative de densité minérale osseuse (DMO) mesurée par absorptiométrie biphotonique (DEXA) observée à long terme au niveau du membre immobilisé des chevaux du groupe placebo. Cet effet préventif ne s’est pas marqué sur le membre controlatéral. Le tiludronate a également induit chez les chevaux traités des chutes rapides et significatives des taux de CTX-1 sérique, contrairement aux chevaux du groupe placebo chez qui ces taux sont restés élevés pendant la quasi-totalité de l’immobilisation. Aucun effet du tiludronate n’a été constaté sur l’activité des iso-enzymes osseuses des phosphatases alcalines (bone ALP), marqueur de formation osseuse, ni sur les caractéristiques du cortex superficiel du canon du membre immobilisé évaluées par ultrasonographie quantitative (QUS). De l’ensemble de ces travaux, il a été conclu que (1) le CTX-1 sanguin est un marqueur de résorption osseuse sensible et adéquat pour le suivi d’un traitement au tiludronate chez le cheval ; (2) le tuber coxae est un site de biopsie osseuse adéquat pour effectuer les analyses nécessaires à l’élaboration d’un modèle PK-PD du tiludronate chez le cheval ; (3) le tiludronate est capable d’inhiber la résorption osseuse dans un modèle d’immobilisation chez le cheval, et la DEXA est une méthode suffisamment sensible pour l’objectiver en quelques mois ; (4) de nouvelles études pharmacologiques devraient être menées afin de documenter l’accumulation osseuse et les effets du tiludronate sur différents paramètres pharmacodynamiques en cas d’administrations répétées de perfusions de 1 mg/kg chez le cheval. Pour ce faire, des techniques plus sensibles de dosage du tiludronate devraient idéalement être utilisées dans un souci d’exactitude des données. D’autre part, de nouvelles études cliniques d’efficacité sur des chevaux souffrant de pathologies osseuses devraient être menées en incluant des mesures de CTX-1, et si possible des mesures de DMO à différents sites d’intérêt. [less ▲]

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See detailOrigine et survivances. L'historique et le transcendantal en tension. Warburg, Cassirer, Panofsky.
Hagelstein, Maud ULg

Doctoral thesis (2008)

Cette étude se divise en trois chapitres principaux, respectivement consacrés aux travaux de Warburg, de Cassirer et de Panofsky. Bien qu’étant organisées de manière chronologique, les trois parties ... [more ▼]

Cette étude se divise en trois chapitres principaux, respectivement consacrés aux travaux de Warburg, de Cassirer et de Panofsky. Bien qu’étant organisées de manière chronologique, les trois parties obéissent à une articulation thématique : la première est consacrée à l’analyse des phénomènes temporels décrits par l’historien de l’art Aby Warburg ; la seconde, à la définition du transcendantal livrée par Ernst Cassirer ; la troisième, à la possibilité d’un « transcendantal historique » favorisée par les travaux d’Erwin Panofsky. Pour poser le cadre de la recherche entreprise ici, on est reparti d’un problème métaphysique important : la définition de l’entreprise critique kantienne à travers la notion de « transcendantal ». En relisant les grands textes de Kant sur la question (Critique de la raison pure / Prolégomènes), on s’aperçoit en premier que le caractère nécessaire et objectif de toute connaissance a priori l’oppose par principe aux analyses historiques. La distinction entre connaissance pure et connaissance empirique est fermement établie. Or, Kant laisse tout de même entrevoir la possibilité d’un « a priori empirique » : dans le domaine même des connaissances a priori, il faut séparer les connaissances pures et empiriques. Certaines propositions peuvent être a priori sans être nécessairement transcendantales. Partant de là, rien n’interdit de reconsidérer le caractère « apriorique » de certaines notions centrales de l’histoire de l’art. Mais peut-on concevoir une approche véritablement transcendantale de l’objet d’art, qui suspende son caractère historique et empirique ? La question de l’« origine » s’avère révélatrice à cet égard. En effet, cette notion complexe peut s’entendre en un double sens (empirique ou non-empirique). Même les études historiennes oscillent entre ces deux acceptions – ce qui amène à interroger la nature même de l’enquête historique. [less ▲]

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See detailStyle beyond Borders: Language in Recent Nigerian Fiction
Tunca, Daria ULg

Doctoral thesis (2008)

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See detailNeuroplasticité saisonnière chez le canari adulte (Serinus canaria): expression des protéines Doublecortin et Reelin et modulation par les hormones stéroïdes, la photopériode et l'environnement social.
Boseret, Géraldine ULg

Doctoral thesis (2008)

Dans de nombreuses espèces d’oiseaux chanteurs (ou Passériformes), dont fait partie le canari domestique (Serinus canaria), le comportement de chant est produit à la fois pour défendre un territoire ou ... [more ▼]

Dans de nombreuses espèces d’oiseaux chanteurs (ou Passériformes), dont fait partie le canari domestique (Serinus canaria), le comportement de chant est produit à la fois pour défendre un territoire ou attirer un partenaire. Le Système de Conntrôle du Chant est un réseau nerveux central spécialisé, principalement localisé au niveau du télencéphale et associé au contrôle de l’apprentissage, la perception et la production du chant. Ce comportement a été décrit subir la modulation de facteurs externes, tels que la testostérone, la photopériode et les interactions sociales. En parallèle avec le comportement de chant, certains des noyaux appartenant au Système de Contrôle du Chant (HVC, RA et Area X) présentent un phénomène de plasticité saisonnière nerveuse fascinante. Le volume de ces noyaux augmente notamment par espacement des cellules, agrandissement de la taille du neuropile et de l’arborisation dendritique et, dans le cas particulier d’HVC, par incorporation de neurones nouveaux-nés. Nous proposons ici une synthèse de la littérature concernant ce phénomène tout à fait particulier ; en effet, la régénération des neurones du système nerveux central est considérée comme inexistante -ou uniquement limitée à la production de quelques interneurones- chez les mammifères. L’étude de la neuroplasticité chez l’oiseau chanteur constitue dès lors un modèle tout à fait remarquable et offrant des perspectives nouvelles dans l’étude du cerveau des vertébrés. [less ▲]

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See detailSynthesis and stabilization of colloids for optical and magnetic detections
Aqil, Abdelhafid ULg

Doctoral thesis (2008)

The development of nano-sized particles is motivated by their optical, electronic and magnetic behavior related to quantum confinement resulting from the nanometric size. To prevent aggregation in ... [more ▼]

The development of nano-sized particles is motivated by their optical, electronic and magnetic behavior related to quantum confinement resulting from the nanometric size. To prevent aggregation in solution, the nanoparticles are covered with stabilizing molecules. The aim of this thesis is to develop a new generation of functional copolymers with different architectures to improve the stability of various synthesized NPs. Two types of nanoparticles are considered, gold NPs for the optical properties and iron oxide NPs for the magnetic properties. The copolymers considered in this study are synthesized following a controlled radical polymerization process, i.e. Reversible Addition - Fragmentation Chain Transfer (RAFT) and confer novel properties to the coated nanoparticles. Stealth NPs are obtained when they are covered by the poly(ethylene oxide), and thermosensitive NPs when they are stabilized by the poly (N-isopropyl acrylamide). These properties have been exploited in applications in the biomedical field. Another challenge in this work is the synthesis and functionalization of the surface of carbon NPs, and thus carbon nano-capsules were synthesized by graphitization of poly (acrylic acid)-poly (acrylonitrile) micelles and carbon nanotubes have been decorated by magnetite NPs allowing their orientation in a magnetic field. [less ▲]

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See detailPolitiques d’approvisionnement dans les systèmes à plusieurs fournisseurs et Optimisation des décisions dans les chaînes logistiques décentralisées
Arda, Yasemin ULg

Doctoral thesis (2008)

Coordinating product flows between the partners of a supply chain is a difficult task because of random variations in demand and supply processes and the antagonistic nature of the individual economic ... [more ▼]

Coordinating product flows between the partners of a supply chain is a difficult task because of random variations in demand and supply processes and the antagonistic nature of the individual economic objectives of the partners. This study concentrates on the management of interorganizational product flows in supply chains. Two approaches are analyzed with the aim of improving performances of production/inventory systems controlled by base stock type product flow control policies. In the first approach, the effects of multi-supplier strategies on the performances of supply chains are studied. It is shown that a multi-supplier strategy decreases the expected replenishment delay and the expected inventory holding and shortage costs. The second approach deals with the deviations from the set of supply chain optimal actions due to the decentralisation of decision rights in a two-stage supply chain. In the game theory framework, the partners play a two-stage game of the Stackelberg type. A coordination contract is proposed and it is shown that the optimal supply chain performance is achievable using the proposed contract. [less ▲]

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See detailEpidemiology and Genetics of Pituitary Tumours
Daly, Adrian ULg

Doctoral thesis (2008)

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See detailHerstelrecht en procedurele waarborgen
Lauwaert, Katrien ULg

Doctoral thesis (2008)

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See detailIn vitro characterisation of dietary fibre fermentation in the pig intestines and its influence on nitrogen excretion
Bindelle, Jérôme ULg

Doctoral thesis (2008)

Increasing attention has been paid to dietary fibre (DF) fermentation in the large intestine of pigs during the past years in pig nutrition. The bacterial growth supported by DF intestinal fermentation ... [more ▼]

Increasing attention has been paid to dietary fibre (DF) fermentation in the large intestine of pigs during the past years in pig nutrition. The bacterial growth supported by DF intestinal fermentation induces a shift of N excretion from urea in urine to bacterial protein in faeces that reduces NH3 emission from the manure. The objective of this thesis was to investigate the relationship between DF fermentability, intestinal bacteria growth and the N excretion. In the first part, an in vitro gas-test method using a living bacterial inoculum developed for ruminants was adapted to the pig. The use of pig colonic content was compared to faeces for the preparation of the inoculum and it was concluded that faeces could replace intestinal content, avoiding the use of cannulated animals. Secondly, the influence of a pespin-pancreatin hydrolysis prior to the fermentation in order to simulate digestion in the stomach and the small intestine was demonstrated. Finally, the influence of the faeces donnor bodyweight and the dietary fibre content of its diet on the gas production kinetics was shown. When studying a topic related to a specific category of pig, it is recommended to use animals from the same category as faeces donors to prepare the inoculum. In the second part of the thesis, the amount of protein synthesis (PS) by faecal microbes fermenting different sources of purified carbohydrates, or ingredients differing in DF content, was measured using 15N-labelled NH4Cl in the inoculum. PS ranged between 9.8 and 22.9 mg N g-1 fermented carbohydrate according to the rate of fermentation of the carbohydrate and its soluble fibre content. These in vitro observations were confirmed through in vivo experiments with diets containing increasing levels of soluble DF: in vitro PS passed from 1.51 to 2.35 mg N g-1 diet while in vivo urinary- N:fecal–N excretion ratio decreased from 2.171 to 1.177. [less ▲]

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See detailCorrosion atmosphérique des bronzes et Spectroscopie Mössbauer.
Sougrati, Moulay Tahar ULg

Doctoral thesis (2008)

The aim of this work is to improve our understanding of the atmospheric corrosion of bronzes. This work focuses on three axes: - The characterization of tin compounds expected in atmospheric corrosion ... [more ▼]

The aim of this work is to improve our understanding of the atmospheric corrosion of bronzes. This work focuses on three axes: - The characterization of tin compounds expected in atmospheric corrosion. The Mössbauer spectroscopy which has been the main tool in our multianalytical approach, allows selective and quantitative analysis. The Mössbauer parameters and f-factors have been determined for many tin oxides, chlorides and sulfates. The f-factors are different from a compound to another and highly T-dependent which justify low temperature Mössbauer measurements. - The development of a low temperature CEMS detector to permit low temperature and non-destructive surface analysis. The detector operation has been optimized for various gases between 41 and 300 K. - The 2-years outdoor exposure in an urban site including CuSn9, CuSn3Zn9 bronzes, CuZn33 brass and pure metals. The corrosion and runoff rates have been investigated as well as the role of alloying elements in corrosion process. [less ▲]

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See detailThermo-plasticity of fine-grained soils at various saturation states: Application to nuclear waste disposal
François, Bertrand ULg

Doctoral thesis (2008)

Soil is a particulate material that may undergo irreversible strain as the relative positions of the constituent particles change. That irreversible behaviour may be induced not only by an external stress ... [more ▼]

Soil is a particulate material that may undergo irreversible strain as the relative positions of the constituent particles change. That irreversible behaviour may be induced not only by an external stress variation but also by temperature or suction changes. The geomaterials that will be involved in the confinement of radioactive waste in deep geological formations will be submitted to strong thermal, hydraulic, and mechanical modifications. Those modifications may produce a significant change of the characteristics of the confinement barrier. A safety assessment of such facilities must be performed that considers the potential thermo-plasticity effects in the confining soil. Following the need for understanding and quantifying such effects, a constitutive model that deals with the thermo-mechanical modelling of unsaturated soils is proposed. In light of elastoplasticity, this model is based on the relevant temperature and suction effects on the mechanical behaviour of fine-grained soils, as observed in experiments. In addition, an experimental program has been undertaken in order to corroborate and to extend the existing results. Finally, the developed constitutive model has been properly implemented in a finite element code in order to study the behaviour of the soils that confine the nuclear waste. Therefore, this work addresses the issue from three different directions: a constitutive, experimental, and numerical point of view. (i) Constitutive study. The elaboration of a thermo-plastic constitutive model for unsaturated soils is done in a systematic manner. Starting from a hardening plasticity model for isothermal and saturated conditions, the constitutive relations are progressively extended to non-isothermal conditions and then to unsaturated states. For the more advanced model, a generalized effective stress framework is adopted, which includes a number of intrinsic thermo-hydro-mechanical connections, to represent the stress state in the soil. Two coupled constitutive aspects are used to fully describe the soil behaviour. The mechanical constitutive part is built on concepts of bounding surface theory and multi-mechanism plasticity, while water retention characteristics are described using elasto-plasticity to reproduce the hysteretic response and the effect of temperature and dry density on the soil's water retention properties. The theoretical formulation is supported by comparisons with experimental results. (ii) Experimental study. Aiming at a better understanding of the non-isothermal mechanical behaviour of unsaturated soils, a series of oedometric compression tests under controlled temperatures and suction conditions has been carried out on a silty material. The characteristics and the calibrations of the experimental apparatus are presented. The main results are interpreted in light of the proposed constitutive framework. The compressibility of the soil tested appears not to be affected by the temperature, but it decreases with a suction increase. As far as the preconsolidation stress is concerned, the results show a decrease of the yield limit with increasing temperature, while a suction increase tends to enhance this limit. Finally, an analytical expression is proposed to describe the evolution of the preconsolidation stress with respect to temperature and suction. (iii) Numerical study. In the issue of nuclear waste disposal, the quantification of the temporal and spatial distributions of the thermo-hydro-mechanical phenomena that occur in the confining soils requires that numerical simulations be carried out under imposed boundary conditions. To this end, the last part of this work presents finite element modelling results of several in-situ or laboratory simulation tests through using the developed constitutive model that was implemented in an advanced finite element code. The parameters of the different materials involved in the simulated experiments are determined by means of an extensive literature analysis on their thermal, hydraulic, and mechanical characteristics. The simulation results are interpreted in light of the elasto-thermoplasticity of saturated and unsaturated soils, which emphasizes the significant role of thermo-plastic processes in the global thermo-hydromechanical response of the confining materials. In that sense, this work supplies, in a systematic and progressive manner, constitutive explanations that may help to provide a better understanding of what the effects of thermo-plasticity in soils involved in the confinement of nuclear waste are. [less ▲]

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See detailStructure et ontogenèse des comportements de banc chez deux poissons Cichlidés: approche quantitative par l'utilisation du vidéotracking automatisé chez Oreochromis niloticus et Pelvicachromis pulcher.
Delcourt, Johann ULg

Doctoral thesis (2008)

Structures and ontogeny of schools in two cichlid fishes: quantitative approach with computerized videotracking systems in Oreochromis niloticus and Pelvicachromis pulcher. by Johann DELCOURT (Behavioural ... [more ▼]

Structures and ontogeny of schools in two cichlid fishes: quantitative approach with computerized videotracking systems in Oreochromis niloticus and Pelvicachromis pulcher. by Johann DELCOURT (Behavioural Biology Unit, Ethology and Animal Psychology, University of Liège, Belgium) The research works presented in this thesis, using new ethometric techniques based on digital imaging analysis, concerns several questions relating to the study of shoaling and schooling behaviours in early stages of life in two Cichlid species. Our two model species, the Nile tilapia (Oreochromis niloticus L.) and Pelvicachromis pulcher, are respectively a mouthbreeder and a substrate breeder. These reproductive and parental strategies have a direct impact on the ontogeny of fry. In this study, we have worked at understanding the impact of these strategies on the ontogeny of shoaling and schooling behaviours. The characterization of these behaviours needed the elaboration of new videotracking systems able to track individually a large number of fish, and the analysis of the spatial and dynamical structure of the group. After an extensive general introduction devoted to the shoaling and schooling behaviours in regards of the ethological study plan, we present our works in three major goals. These three topics concern: 1. Lab works using some classical methods of direct observation and a technique of computerised vision systems (Ethovision®). Moreover, Laboratory studies of fish groups were conducted to develop a new multitracking system, in collaboration with the G.R.A.S.P. (ULg), able to track a large number of unmarked individuals (up to 100 fishes) during several minutes. Thanks these two tracking systems, we studied the fry behaviours at the individual and the groups levels. 2. The emergence conditions of these behaviours. Are the fry able to adopt these behaviours in absence of parents, in absence of external stimuli? In this context, we described the spatial and dynamical (local and global) structures of groups to understand the mechanisms allowing the existence of schools. 3. The ontogeny of shoaling and schooling behaviours in the two model parental species. The first part exposes research devoted to the application, development and validation of the use of two videotracking systems (presented in the material and methods section). The advantages, capacities and limits of these systems are presented. The work concerning the emergence (the mechanisms) and the ontogeny are presented in scientific paper format in the “Results” section. A large general discussion centred on the three major goals (development of new ethometric tools, the structures and mechanisms of schools and the ontogeny of shoaling and schooling behaviours) concludes this PhD dissertation. [less ▲]

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See detailConception et réalisation d'un dispositif interférométrique de shearographie. Application en milieu diffusant.
Rosso, Vanessa ULg

Doctoral thesis (2007)

L’objectif de cette thèse était de concevoir et développer un dispositif expérimental réalisant des mesures dans la gamme micrométrique, qui soit compact, transportable et le plus stable possible pour la ... [more ▼]

L’objectif de cette thèse était de concevoir et développer un dispositif expérimental réalisant des mesures dans la gamme micrométrique, qui soit compact, transportable et le plus stable possible pour la réalisation de mesures in-situ. Ce projet a donc contribué à la conception et à la réalisation d’un dispositif interférométrique de shearographie qui constituera une base pour de futurs développements. Un interféromètre original de shearographie à chemins optiques quasi-communs et utilisant la technique du décalage de phase temporel a été présenté dans ce travail. L’élément clef du montage expérimental de shearographie est le dispositif de cisaillement (« shearing device », en anglais) : il s’agit d’un prisme qui sépare les états de polarisation TE et TM grâce à une couche mince polarisante et une fine lame de verre qui lui est accolée. Cet élément de cisaillement ainsi que l’utilisation d’une caméra CMOS et d’une cellule à cristaux liquide pour modulateur de phase, ont permis la réalisation d’un interféromètre compact, en ligne, relativement bon marché et à chemins optiques quasi-communs, lui conférant ainsi une grande stabilité par rapport aux perturbations extérieures. De plus, la sensibilité de cet interféromètre peut être ajustée pour différentes applications en modifiant la distance de cisaillement, par exemple en utilisant une lame de verre d’épaisseur différente accolée au prisme séparateur de polarisation. Des logiciels pour l’acquisition et le traitement des images ont également été développés afin de rendre le système simple d’utilisation et convivial. L’efficacité de cet interféromètre de shearographie a été prouvée dans le domaine mécanique et une application originale a été développée dans le domaine de la biophotonique. [less ▲]

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See detailL’Imaginaire des Pays-Bas dans la littérature française du XIXe siècle
Andringa, Kim ULg

Doctoral thesis (2007)

The imagination of the Netherlands comes close to a mythoid aggregate. The corpus transmits a superficial and picturesque imagery, based on tourist, pictorial and historical sources. The tourist ... [more ▼]

The imagination of the Netherlands comes close to a mythoid aggregate. The corpus transmits a superficial and picturesque imagery, based on tourist, pictorial and historical sources. The tourist conventions reinforce its stereotypical and anachronistic nature. The anachronism is also typical of the images borrowed from paintings of the Dutch school and a few art historians. Realism is most appreciated when poetically tinged, as with Rembrandt who reveals the boundary between dream and reality. History provides the authors with heroic or dramatic episodes, as well as with legends expressing national character or the struggle against the waters. At the dawn of the 20th century, the imagination of the Netherlands becomes more introspective. Societal changes and especially the industrialisation put the place of man in question. We have subjected three groups of images to a symbolical analysis. First, the group of miniaturised dwelling places, that express a unfulfilled desire for intimacy and a refuge out of time. Then, a group related to the painting as a mirror. These boundary images of an inaccessible space express the same disappointed desire. The sea images express progressive ideas as well as fear of mechanization at the same time. The illusion of the fantastic and the phantasmagoria make it possible to vanquish the setbacks suffered through the figures of intimacy. Against the industrialisation, against the changes of modern society, as well as against mass tourism, the author will oppose his imaginary experience of the world, and through his description will give a autoreferential image, revealing of his dreams and desires. L’imaginaire des Pays-Bas se rapproche d’un agrégat mythoïde. Le corpus véhicule une imagerie superficielle et pittoresque, construite autour de sources touristiques, picturales et historiques. Les conventions du tourisme en renforcent le caractère stéréotypée et anachronique. L’anachronisme caractérise aussi les images empruntées aux tableaux de l’école hollandaise et à quelques historiens de l’art. Le réalisme est surtout apprécié lorsqu’il est mêlé de poésie, comme chez Rembrandt qui révèle la frontière entre réel et rêve. L’Histoire fournit aux auteurs des épisodes héroïques ou dramatiques, et des légendes traduisant le caractère national ou la lutte contre les eaux. À l’aube du 20e siècle, l’imaginaire des Pays-Bas devient plus introspectif. Les changements sociétaux et surtout l’industrialisation remettent en cause la place de l’homme. Nous avons soumis trois groupes d’images à une analyse symbolique. D’abord celui des habitations miniaturisées, exprimant un désir d’intimité et de refuge hors du temps non satisfait. Le second se rattache à la peinture qui devient miroir. Ces images frontalières d’un espace inaccessible expriment le même désir déçu. Les images marines véhiculent à la fois des idées progressistes et la peur du machinisme. L’illusion du fantastique et de la fantasmagorie permet de surmonter les échecs rencontrés par les figures de l’intimité. À l’industrialisation, aux changements de la société moderne, au tourisme de masse aussi, l’auteur va opposer son expérience imaginaire du monde et à travers sa description, il va donner une image suiréférentielle révélatrice de ses rêves et désirs. [less ▲]

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See detailLe réveil de l’immatériel. La production onirique du patrimoine des Indiens Zápara (Haute Amazonie)
Bilhaut, Anne-Gaël ULg

Doctoral thesis (2007)

The Zapara Indians in the Upper Amazon are on the verge of disappearing from the linguistic map. This is a fact. And yet, their emergence within the political landscape in Ecuador (but not yet in Peru ... [more ▼]

The Zapara Indians in the Upper Amazon are on the verge of disappearing from the linguistic map. This is a fact. And yet, their emergence within the political landscape in Ecuador (but not yet in Peru), has provided them with a greater international visibility as an indigenous group. Most unusually, the accounts of dreams become one of the key elements of new forms of identity practices and identification processes – as those narrated here by two Zapara political leaders will attest. In search of their material and immaterial heritage, these leaders make use of the realm of dreams, using occurred dreams to orient their choices in the reconstruction of a collective memory. The dream, as a tool for engaging in a regredient process or in the return into the past, provides the historical elements that the Indians will then re-inject into their present in order to construct new “traditions”. In this dissertation, I will be describing the mechanisms, the learning of, and the local theories concerning the experience of dreams. In order to be understood, the dream must first circulate, and must have an issuer as a point of departure. Dreaming is also the means for a privileged relationship between human and non- human beings. Throughout this thesis, various systems of memory will be examined based upon empirical data revealing of the dreamt experience, but also of daily life, such as new teaching methods, or the creation of artefacts, produced both by ancestors or contemporaries. These accounts will help us to understand this new process of “Zaparaisation”, which depends as much on a process of ethno-archiving than on ethno-museography, and which awakens the immaterial. [less ▲]

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See detailCaractérisation physiologique et biochimique du processus de vieillissement du tubercule de pomme de terre (Solanum tuberosum L.)
Delaplace, Pierre ULg

Doctoral thesis (2007)

Potato seed tuber is considered as a model organ to study plant ageing. Besides, its physiological age greatly influences germination pattern and thus agronomical performance. In order to unravel the ... [more ▼]

Potato seed tuber is considered as a model organ to study plant ageing. Besides, its physiological age greatly influences germination pattern and thus agronomical performance. In order to unravel the biochemical processes underlying ageing, potato seed tubers (cv. Bintje and Désirée) were stored at 4°C for 7 months and regularly sampled to assess both physiological and biochemical parameters. Physiological age markers (PAI, incubation period) evolution was measured and allowed us to define a reference frame more accurate than the chronological age. A correlation has also been established with the growth parameters (number of stems, duration before emergence). In parallel, two biochemical approaches allowed us to assay proteome and antioxidant system modifications occurring during ageing. Protein pattern evolution was assessed by DIGE after hot SDS extraction. During ageing, 93 spots were strictly up- or down- regulated while 4 others exhibited an abundance curve with a transient maximum. After manual picking of 43 selected spots based on their expression profile, 32 proteins were identified by MS/MS. Differentially expressed proteins are mainly involved in patatin catabolism, stress response, glycolysis, protein turn-over and lipid oxidation. A complementary targeted approach has then been set up based on the free radical ageing theory. SOD, CAT, APX and POX activities as well as ascorbate, glutathione, carotenoid and phenolic compound contents were measured during ageing. These data seem to indicate that the antioxidant system undergoes marked changes in response to an increased production of reactive oxygen species. However, no accumulation of oxidative damages has been observed on lipids and proteins. All these kinetic data allowed us to build an integrated ageing model. These results are discussed in the above-mentioned theoretical context. [less ▲]

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See detailThe synchronic layering of English size and Type noun constructions
Brems, Lieselotte ULg

Doctoral thesis (2007)

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See detailContribution au diagnostic et à la correction des carences en iode et sélénium chez les bovins
Guyot, Hugues ULg

Doctoral thesis (2007)

Deficiencies of selenium (Se) and iodine (I) are widespread in livestock all over Europe. They have an impact on the animals’ health. Since the clinical signs of the deficiencies are rarely pathognomic ... [more ▼]

Deficiencies of selenium (Se) and iodine (I) are widespread in livestock all over Europe. They have an impact on the animals’ health. Since the clinical signs of the deficiencies are rarely pathognomic, auxiliary exams, based on blood and milk samples are needed for the confirmation of the diagnosis. To evaluate the Se and I status, the plasmatic Se content, the erythrocytic glutathione peroxydase activity (GPX), and the inorganic plasmatic I (IIP) content are measured routinely. Other analyses, like e.g. the dosage of tri-iodothyronine (T3) or thyrotropine (bTSH) can be used. Once the deficiency is diagnosed, it can be corrected by several methods. The first aim of the study was to evaluate the zinc, copper, Se, and I status of Wallonian dairy and beef herds and to correlate their trace element status to their health. The trace element status of the herds with pathologies was less good than that of healthy herds. Further, more herds with pathologies had deficiencies when compared to healthy ones. Dairy herds had a better trace element status than beef herds. Se and I deficiencies are among the most important ones and have the most severe sequels. Therefore, the subsequent parts of the study focussed on these two trace elements. The second aim was the establishment of a technique for the dosage of bTSH and of reference values in healthy cattle. Reference ranges for bTSH and for thyroxine (T4) have been determined in healthy adult cows and in healthy calves. Thereafter, the next aim was to compare the concentration of bTSH in newborn calves with goitre to those obtained in healthy calves, in order to validate a diagnostic test for this pathology. The bTSH allowed the discrimination of the two groups and to approve the diagnosis of hypothyroidism in some of the calves. The threshold value of bTSH for the diagnosis of hypothyroidism in the newborn calf has been fixed at 35 µU/ml. The fourth aim was to compare the I (IIP) and Se (plasmatic Se, GPX) status as well as the thyroid status (bTSH, T4, T3, rT3) in dried pregnant cows and their calves and in non-pregnant cows, that received normal diet and a diet enriched in Se and I. In those receiving a Se and I enriched diet, the T4 and the bTSH decreased while the IIP, the T3, and the GPX activity increased. In the group that received a diet with normal Se and I contents, only the GPX activity increased. At birth, calves from mothers receiving the Se and I enriched diet, had a higher IPP content and GPX activity, and a lower bTSH concentration than calves from the other group. The last aim was to compare the effects of two different forms of Se (sodium selenite versus seleno-methionine) and two different doses of Se (0.1 versus 0.5 ppm) on the health and the Se status of Se deficient Belgian Blue cows and their calves. The first two groups of cows received a ration with 0.1 and 0.5 ppm, respectively, of Se in the form of sodium selenite (Na-Se 0.1 and Na-Se 0.5), while the third group received 0.5 ppm of Se in the form of seleno-methionine (Y-Se 0.5). The Se content of plasma, colostrum, and milk was higher in the cows of group Y-Se 0.5 when compared to the two other groups. The Se content of the plasma was higher in calves from group Y-Se 0.5 when compared to the two other groups. The daily weight gain of the Y-Se 0.5 group was higher than those of the group Na-Se 0.1. The incidence of diarrhoea among calves in group Na-Se 0.1 was higher than in group Y-Se 0.5. In conclusion, trace elements deficiencies are common in Wallonia and often they are multiple. They play a major role in the aetiology of multifactorial diseases diagnosed in the cattle herds. Deficiencies in Se and in I are most commonly implicated in clinical problems. The diagnosis of these deficiencies is determined by blood analyses. Therefore, the tests need to be differentiated according to their capacity to test the nutritional or the thyroid status. A simultaneous supplementation with I and Se, as well as the form of the supplemented Se, may modify the interpretation of the nutritional and the thyroid status. Better reproduction performances and a better health have been observed in herds with a normal trace element status. Furthermore, the advantage of the supplementation with Se in the form of seleno-methionine has been demonstrated in comparison to sodium selenite in deficient Belgian Blue cattle. This study opened numerous perspectives. The measurement of bTSH should be implemented in laboratories in order to offer it as a routine analysis to the practitioning veterinarian, who could use this tool in the framework of many diseases other than goitre. From a fundamental point of view, the dosage of deiodinases would allow the understanding of the regulation and of the synthesis of the thyroid hormones in bovines, and identifying the role of Se and I in this process. Finally, following the discoveries concerning the seleno-methionine, the effect of organic forms of other trace elements in bovine supplementation should be investigated. [less ▲]

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See detailApport de données d’ADN nucléaire à la Phylogénie et à la Biologie de la Conservation des Ursidae
Pagès, Marie ULg

Doctoral thesis (2007)

Currently, the Ursidae family includes eight bear species. They represent an unusual family within the order of the Carnivores because of their peculiar physiological adaptations related to hibernation ... [more ▼]

Currently, the Ursidae family includes eight bear species. They represent an unusual family within the order of the Carnivores because of their peculiar physiological adaptations related to hibernation. These physiological features, unique in the animal kingdom, make bear a unique model for medical research in full expansion because of its putative clinical applications. This point will be developed in introduction of this manuscript. Surprisingly, the phylogenetic relationships within the extant Ursid representatives remain unclear. In order to clarify their phylogeny, we sequenced 12 nuclear genes for all the Ursid species (nearly 8 kilobases corresponding to 6 genes implied in the pathway of the thyroid hormones, 3 genes specific to the sexual chromosomes, and 3 other autosomal genes). By concatenating these new data with those available in the sequence databanks, phylogenetic reconstructions (maximum likelihood and bayesian analyses) were carried out on a nuclear DNA dataset of 10 kilobases. It was then possible to refine the phylogeny of the Ursidae family. In addition, based on the study of the genes SRY (Sex determining region of the Y chromosome), ZFX/ZFY (Zinc Finger protein) and AMLX/AMLY (Amelogenine), we developed a reliable method to determine the sex of Ursidae based on the analysis of DNA extracted from non invasive samples such as hairs or faeces. If this tool has obvious implication for the conservation biology of Ursidae (most of the extant species are threatened with extinction), it also opens new prospects in palaeontology. This kind of analysis was indeed applied to samples of fossils of North African brown bears (Ursus arctos). The last chapter of this manuscript illustrates how the palaeogenetics can help palaeontology interpreting the variability of fossil forms. [less ▲]

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See detailSynthesis, characterization and applications of pH-responsive core-shell-corona micelles in water
Willet, Nicolas ULg

Doctoral thesis (2007)

ABC triblock copolymers self-organize into a wide variety of supramolecular structures in the bulk. However, their associative behavior in selective solvents has scarcely been studied. Within the search ... [more ▼]

ABC triblock copolymers self-organize into a wide variety of supramolecular structures in the bulk. However, their associative behavior in selective solvents has scarcely been studied. Within the search for new stimuli-responsive supramolecular architectures, our attention focused on a pH-responsive polystyrene-b-poly(2-vinylpyridine)-b-poly(ethylene oxide) (PS-b-P2VP-b-PEO) triblock copolymer. In addition to the synthesis of monodisperse spherical core-shell-corona (CSC) micelles, the reversibility and the cooperativity of the response to pH variations were studied, morphological transitions were induced and multi-responsive micellar gels were prepared. The micellization mechanism, the structure, the responsiveness and the internal organization of these new nanomaterials were investigated using a combination of transmission electronic microscopy, atomic force microscopy, light scattering, small-angle neutron and X-ray scattering, nuclear magnetic resonance and rheology. Finally, efforts were geared towards potential applications. The ability of PS-b-P2VP-b-PEO CSC micelles to encapsulate and release hydrophobic species was probed and gold nanoparticles were successfully synthesized within the P2VP layer of spherical and cylindrical micelles, which acted as nanoreactors. [less ▲]

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See detailSimulation et aide au dimensionnement des chaudières de récupération
Dumont, Marie-Noëlle ULg

Doctoral thesis (2007)

Heat recovery steam generators (HRSG) play a very important role in combined cycle (CC) power plants, where steam is generated from a gas turbine exhaust and supplied at the appropriate pressure and ... [more ▼]

Heat recovery steam generators (HRSG) play a very important role in combined cycle (CC) power plants, where steam is generated from a gas turbine exhaust and supplied at the appropriate pressure and temperature to steam turbines for further power generation. The power plants achieve an overall efficiency above 55% and are ideally suited for combined heat and power generation in utility systems. The performance of energy conversion is improved by reducing exergy losses which implies reducing the temperature difference between the combustion gas and the steam cycle. Thus recent HRSG designs include up to three pressure levels with reheat in the steam cycle for maximum energy recovery and the use of high pressure, high temperature superheater and reheater in CC plants. Super critical boilers are also conceivable. Since HRSG performance has a large impact on the overall efficiency of the CC power plant, an accurate simulation of the performance of the HRSG is necessary. We present a steady state HRSG model to support design and rating simulations of vertical units. The simulation model, called FELVAL, divides the boiler in its rows. The row model can also be divided several times following the tube length, to better estimate the fumes temperature distribution across the hot gas path. Another model, called SUFVAL, carries out the design as well as the automatic generation of the FELVAL units and all the needed connections. The log mean temperature difference (LMTD) method and the effectiveness-NTU (ε -NTU) method are alternatively used to compute the overall heat transferred in each part of the HRSG. The problem of convergence of boiler models with more than one row in parallel is discussed. Good initialisation of the different variables is crucial to obtain convergence. The models are tested on 2 references HRSG. The first one is an assisted circulation boiler that operates at 3 subcritical pressure levels. The second is a once through boiler able to operate above the critical pressure of water. These new models were introduced into a commercial software of data reconciliation (VALI of Belsim sa) already used by the engineering and design departments of a HRSG manufacturer. They thus have a general-purpose package enabling them to make design, data reconciliation and simulation with the same software. Moreover, the use of FELVAL model will enable them to simulate any type of boiler and to obtain informations on the change of the temperatures inside the heat exchangers. This information is crucial for well monitoring closely the operation of a boiler, and better understanding its behaviour. This knowledge improvement allows to limit the overdesign and the safety margins and to reduce the investment costs. [less ▲]

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See detailNonvisual brain responses to light exposure in human as assessed by functional magnetic resonance imaging
Vandewalle, Gilles ULg

Doctoral thesis (2007)

La lumière influence profondément la physiologie humaine, en plus de permettre la vision. Elle constitue le synchronisateur principal des rythmes circadiens et induit des effets physiologiques immédiats ... [more ▼]

La lumière influence profondément la physiologie humaine, en plus de permettre la vision. Elle constitue le synchronisateur principal des rythmes circadiens et induit des effets physiologiques immédiats. Ces effets concernent des fonctions non-visuelles telles que la régulation du rythme veille/sommeil, de la température corporelle, de fonctions endocrinologiques, de l’éveil et des performances. Plusieurs études de ces effets réalisées chez l’animal et chez l’homme ont montré l’implication d’un système de photoréception non-visuel sensible surtout aux courtes longueurs d’onde (~470nm ; bleu). Ce système utilise les photorécepteurs classiques (cônes et bâtonnets), en plus de cellules ganglionnaires rétiniennes (CGR) intrinsèquement photosensibles, et exprimant la mélanopsine. Ces CGR se connectent à de nombreux noyaux sous-corticaux et corticaux, ce qui suggère un rôle du système non-visuel dans de nombreuses fonctions cérébrales. Cependant, au delà de ces projections rétiniennes directes, les autres régions du cerveau impliquées sont très peu connues. Une étude en tomographie par émission de positons (TEP), réalisée à l’Université de Liège, a démontré que l’effet éveillant d’une lumière nocturne intense (>8000lux) pouvait moduler l’activité cérébrale liée à une tâche attentionnelle. Cette étude, ainsi que quelques données d’EEG, résume notre connaissance des mécanismes cérébraux impliqués dans le système non-visuel chez l’homme. De plus, la majorité des études sur ces effets ont été entreprises la nuit. Nous avons réalisé trois études en imagerie fonctionnelle par résonance magnétique (IRMf) utilisant des expositions lumineuses diurnes pour mieux caractériser le système cérébral non-visuel chez l’homme. L’IRMf bénéficie d’une meilleure résolution spatiale et temporelle que la TEP et permet la caractérisation d’activités cérébrales liées à un processus cognitif précis. La première étude met en évidence des réponses cérébrales liées à une tâche attentionnelle avant et après une exposition lumineuse intense (>7000lux) de 21min. L’amélioration de l’éveil subjectif induite par la lumière est liée à une augmentation de l’activité thalamique. De plus, la lumière augmente l’activité d’un réseau de régions corticales impliquées dans la tâche, prévenant les diminutions d’activités observées en obscurité continue. Ces augmentations déclinent en quelques minutes après l’arrêt de la lumière, en suivant des dynamiques diverses spécifiques à chaque région. Ces premiers résultats suggèrent que, via une modulation de l’activité de structures sous-corticales régulant l’éveil, la lumière peut promouvoir dynamiquement l’activité corticale de réseaux impliqués dans un processus cognitif non-visuel. La deuxième étude montre que de courtes expositions (18min) à des lumières monochromatiques (3x1013ph/cm2/s) bleues (470nm) ou vertes (550nm) affectent différemment les réponses cérébrales liées à une tâche de mémoire de travail. La lumière bleue augmente les réponses cérébrales ou, du moins, prévient les diminutions observées sous lumière verte dans des cortex pariétaux et frontaux impliqués dans la mémoire de travail, ainsi que dans le thalamus. Ces résultats montrent qu’une lumière monochromatique peut rapidement influencer les fonctions cognitives et suggèrent que ces effets sont induits via un système de photoréception qui utilise la mélanopsine. Ces résultats démontrent qu’une exposition lumineuse diurne peut moduler l’activité cérébrale non-visuelle liée à deux fonctions cognitives complexes. La lumière agit rapidement en fonction de la région cérébrale et de la longueur d’onde considérées. Les sensibilités aux différentes longueurs d’ondes suggèrent l’implication d’un système de photoréception utilisant la mélanopsine. XXX. Les résultats suggèrent également une implication étendue de la lumière dans la régulation des fonctions cérébrales chez l’homme et soutiennent son utilisation pour contrecarrer la somnolence diurne et traiter des désordres circadiens et psychiatriques. [less ▲]

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See detailL’interface neuro-immune et l’expression de la protéine prion cellulaire dans le cadre des maldies à prions. Une étude comparative des espèces bovine et humaine.
Defaweux, Valérie ULg

Doctoral thesis (2007)

Le tropisme cellulaire des prions infectieux diffère selon l’espèce animale, celui-ci est corrélé à la souche infectieuse et à des facteurs spécifiques de l’hôte. Par exemple, certains prions infectieux ... [more ▼]

Le tropisme cellulaire des prions infectieux diffère selon l’espèce animale, celui-ci est corrélé à la souche infectieuse et à des facteurs spécifiques de l’hôte. Par exemple, certains prions infectieux sont lymphotropiques, notamment en cas de scrapie chez les moutons et de variant de la maladie de Creutzfeldt-Jakob (vMCJ) chez l’homme. Par opposition, certains prions se caractérisent par un neurotropisme comme observé chez des patients Creutzfeldt-Jakob atteints de la forme sporadique ou chez des bovins atteints d’encéphalopathies spongiformes bovines (ESB). L’hypothèse de notre travail repose sur les observations suivantes : dans le cas du variant de la maladie de Creutzfeldt-Jakob et des encéphalopathies spongiformes bovines, l’agent responsable est identique, la voie d’inoculation et les lésions neurologiques le sont également, seul le tropisme de cette souche pour les organes lymphoïdes diffère. En effet, les amygdales, la rate et l’appendice sont infectieux chez l’homme. Par contre, l’infectiosité est surtout confinée au niveau du système nerveux chez le bovin. Lors d’une inoculation expérimentale par voie orale de l’agent responsable de l’ESB chez les bovins, les plaques de Peyer iléales sont les seuls tissus lymphoïdes infectieux. Notre hypothèse de travail est que des propriétés de l’hôte interviennent dans le tropisme de l’agent infectieux. Deux axes de recherche ont été envisagés afin de vérifier cette hypothèse :  L’analyse de la distribution des fibres nerveuses au sein des tissus lymphoïdes associés aux muqueuses (MALT) des espèces bovine et humaine  L’étude de l’expression de PrPc et de ses isoformes au sein des tissus lymphoïdes et nerveux des espèces bovine et humaine. Pour atteindre au mieux nos objectifs, il nous manquait un outil essentiel permettant la caractérisation spécifique des FDC bovines. En effet, aucun marqueur spécifique de ces cellules n’était commercialisé. Nous avons donc produit, en collaboration avec le Centre d’Economie Rural de Marloie, un anticorps monoclonal spécifiquement dirigé contre les cellules folliculaires dendritiques (FDC) bovines. Cet anticorps nous a permis d’étudier la distribution des FDC au sein des organes lymphoïdes bovins. Une attention particulière a été portée aux FDC isolées à partir des plaques de Peyer jéjunales (PPJ) et iléales (PPI). L’apparente différence d’infectivité de ces tissus lymphoïdes chez des bovins atteints expérimentalement d’ESB nous a conduit à comparer les capacités fonctionnelles des FDC isolées à partir de PPJ et de PPI. Ces observations sont décrites et discutées dans le chapitre 1. Dans le chapitre 2, nous avons établi une cartographie des fibres nerveuses au sein des amygdales, des plaques de Peyer iléales et jéjunales bovines de plusieurs catégories d’âge et ensuite comparé ce pattern d’innervation à celui des amygdales humaines; ceci permettra de pister les voies potentielles de neuro-invasion. Une attention particulière a été portée à l’interface cellules folliculaires dendritiques – fibres nerveuses. En effet, les FDC matures jouent un rôle prépondérant dans la pathogenèse des maladies à prion puisqu’en leur absence, une infection périphérique n’a pas lieu. De plus, la proximité entre fibres nerveuses et FDC est un paramètre intervenant dans la neuro-invasion; nous avons dès lors aussi analysé les contacts entre les FDC et les éléments nerveux. L’expression de la PrPc est une condition sine qua non pour la formation de PrPres. Cette protéine cellulaire sert probablement de récepteur pour son homologue infectieux mais sert surtout de substrat pour l’amplification de PrPres ; toute modification au niveau de sa synthèse pourrait entraîner un changement de la cinétique d’infection et pourrait expliquer l’apparente absence d’infectivité constatée au niveau du système immunitaire chez les bovins. L’expression tissulaire et cellulaire spécifique d’isoformes de la PrPc représente un facteur de l’hôte potentiellement capable d’influencer le tropisme cellulaire de l’agent infectieux chez l’humain et le bovin. Cette expression a été étudiée dans les systèmes MALT bovins et humains. Pour affiner notre étude, nous avons analysé, par des techniques de western-blotting, le glycopattern de la PrPc ainsi que l’expression de ses formes tronquées dans les tissus lymphoïdes humains et bovins mais également dans des populations cellulaires spécifiques, les lymphocytes et les FDC. Afin de vérifier si les isoformes de PrPc sont spécifiques aux tissus lymphoïdes, nous avons effectué une étude comparative du pattern de glycosylation et du ratio des formes clivées de PrPc, exprimés au sein de différentes régions du système nerveux central bovin et humain. Les résultats de ces travaux sont repris dans le chapitre 3. [less ▲]

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See detailPathogénie cellulaire et moléculaire du stress oxydatif dans l'ostéo-arthropathie dégénérative équine
Schneider, Nicole ULg

Doctoral thesis (2007)

L’ostéo-arthropathie dégénérative affecte fréquemment les chevaux, et particulièrement le cheval de trait ardennais (Lejeune et al., 2002). Les nombreuses recherches consacrées à cette pathologie montrent ... [more ▼]

L’ostéo-arthropathie dégénérative affecte fréquemment les chevaux, et particulièrement le cheval de trait ardennais (Lejeune et al., 2002). Les nombreuses recherches consacrées à cette pathologie montrent un phénomène inflammatoire et un déséquilibre entre la production des enzymes dégradant le cartilage et l’intensité du processus de régénération (Landoni et al., 1996). On observe donc des dégâts à la surface du cartilage : f ibrillation, érosion, ulcération, formation d’ostéophytes, sclérose de l’os sous-chondral et remodelage ostéochondral (Reboul et al., 1996). Tous les éléments anatomiques sont concernés, avec une libération de médiateurs par les chondrocytes et les synoviocytes : cytokines, métalloprotéases, prostanoïdes (Cadore et Donabedian, 1997), leucotriènes, et espèces activées de l’oxygène et de l’azote (RNOS : reactive nitrogen and oxygen species). La formation des RNOS est souvent invoquée en relation avec des phénomènes d’anoxie-réoxygénation cycliques, liés au trauma ou à la surcharge articulaire, à un épanchement ou à un oedème de la capsule articulaire. Les travaux consacrés à la production des RNOS dans l’articulation l’attribuent habituellement aux chondrocytes et des observations biochimiques récentes ont révélé une augmentation des concentrations sanguines d’un produit oxydé caractéristique de la dégradation du cartilage, signe d’un métabolisme oxydant intra-articulaire (Lejeune et al., 2007). Peu de travaux sont consacrés à l’étude directe d’une production d’espèces radicalaires par les chondrocytes et les synoviocytes. L’objectif du travail était donc d’étudier la capacité des chondrocytes et des synoviocytes articulaires équins à produire des RNOS sous l’effet de l’anoxieréoxygénation. Il nécessitait la mise au point d’un modèle de culture des chondrocytes équins (Sanchez et al., 2002), d’un modèle de culture des synoviocytes équins (Georgescu et al., 1988) et d’un modèle de co-culture chondrocytes-synoviocytes pour imiter les interactions entre ces deux types cellulaires dans l’articulation où les chondrocytes matures sont nourris par diffusion à partir du liquide synovial à basse tension en oxygène (Grimshaw et Mason, 2000). Pour induire l’activité oxydante, nous avons soumis les cellules en culture à plusieurs cycles d’anoxie-réoxygénation, sur base de l’hypothèse qu’un traumatisme aigu ou chronique peut modifier le débit sanguin dans la membrane synoviale et initier des cycles d’anoxie-réoxygénation (par oedème et hypoxie tissulaire transitoire), avec une production intra-articulaire de RNOS, capables de déclencher des dommages tissulaires participant au développement de la pathologie articulaire. Pour tenir compte des conditions en oxygène existant dans l’articulation et du rôle du glucose ajouté au milieu de culture dans la résistance à l’anoxie, les chondrocytes ont été cultivés avec des concentrations variables en glucose (0, 1 et 4,5 g/l de milieu), combinées aux tensions d’oxygène de 1 % (hypoxie), 5 % (équivalent à la normoxie in vivo) et 21 % (condition hyperoxique prise comme référence par rapport à la littérature internationale). L’étude du métabolisme oxydant est effectuée en mesurant la consommation d’oxygène [oxymétrie mesurant la réponse mitochondriale (Mouithys- Mickalad et al., 2002)], la production globale de RNOS [estimée par la mesure de l’éthylène, produit par l’attaque d’un substrat par les RNOS (Deby-Dupont et al., 2005)] et la production d’espèces radicalaires [par résonance paramagnétique électronique (RPE) couplée au « spin trapping »] [less ▲]

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See detailGlobalisation, communication et champ du pouvoir : une socio-économie comparée des structures actionnariales et dirigeantes des groupes de médias et des entreprises dans le domaine des Nouvelles Technologies de l’Information et de la Communication en Europe et aux États-Unis
Geuens, Geoffrey ULg

Doctoral thesis (2007)

Les « Nouvelles Technologies de l’Information et de la Communication » (NTIC) font aujourd’hui l’objet d’une abondante littérature, tant francophone qu’anglo-saxonne. L’objectif de la thèse était ... [more ▼]

Les « Nouvelles Technologies de l’Information et de la Communication » (NTIC) font aujourd’hui l’objet d’une abondante littérature, tant francophone qu’anglo-saxonne. L’objectif de la thèse était précisément de soumettre à l’analyse critique cette prolifération de discours le plus souvent clichés – associés, pour les uns, à la « société de l’information », pour les autres, à la « mondialisation » de l’économie – qui forment presque un discours social à part entière, et dont l’un des traits communs est notamment de révoquer en doute, à l’exemple des phénomènes examinés sous le point de vue qu’ils adoptent, les principaux référents théoriques d’antan. Les « idéologèmes » véhiculés par ce discours social, on l’a montré, relèvent pour l’essentiel de trois grandes catégories particulièrement saillantes, organisées en l’occurrence sous la forme de trois binômes largement reçus, qui tendent à fonctionner comme des structures de pensée communes : a)Privatisation/désétatisation. La croyance en l’omnipotence des communications de masse va, le plus souvent, de paire avec la thèse du déclin présumé de l'Etat-nation ; les « nouveaux médias » et les NTIC libéralisés ayant, dit-on, acquis leur autonomie et plaçant nos sociétés à l’enseigne du réticulaire marchand. La « nouvelle économie » en réseaux se serait définitivement libérée de la tutelle politique, pour le meilleur (dynamisme, efficacité, compétitivité) comme pour le pire (marchandisation, affaiblissement de l’État, soumission du politique), selon le point de vue adopté à l’égard de ces évolutions données pour inévitables ; b)Mondialisation/déterritorialisation. L’internationalisation des structures de pouvoir des groupes de communication entretient une relation organique avec la dépolitisation du secteur. C’est que l’explication majeure de la disjonction État/médias réside, justement, dans la logique de dissociation croissante entre l’espace démocratique national et les réseaux technologiques mondiaux. Les nouveaux conglomérats de l’information s’identifieraient alors à des géants transnationaux apatrides et déterritorialisés. Quant à la « financiarisation » des industries culturelles, elle annoncerait la fin des actionnaires de références nationaux et l’avènement parallèle d’une nouvelle économie s’appuyant sur une multitude de petits porteurs disséminés aux quatre coins de la planète dont les investisseurs institutionnels constituent, en quelque sorte, le modèle le plus abouti ; c)Libéralisation/dérégulation. La « dépolitisation » et la « globalisation » des industries technologiques auraient instauré un marché débarrassé des entraves et des privilèges associés aux anciens opérateurs publics. Décidées au nom du libéralisme économique, les réformes de dérégulation adoptées dès le début des années 80 auraient ainsi abouti à la décomposition des antiques monopoles et à la mise en concurrence d’entités industrielles isolées les unes des autres. Quant aux conquérants de la Silicon Valley, Media Moguls et autres Tycoons, ils seraient en quelque sorte les effigies suprêmement individuelles de cette métamorphose du « capitalisme numérique » : autant de managers déracinés, dépeints comme d’infatigables compétiteurs apolitiques, engagés dans une course féroce au gigantisme, n’ayant pas la moindre solidarité de classe et n’ayant pour seul moteur que la quête du profit à court terme. Les discours convenus touchant à la « société de l’information » et aux phénomènes de « globalisation », il nous faut en réalité les relativiser, sinon même les infirmer, à la lumière de nos observations et analyses. C’est que la « mondialisation » de l’économie doit en effet compter non seulement avec la permanence de particularismes nationaux dont témoignent les structures de détention et de contrôle des groupes de médias et des NTIC, mais également avec le fait que la très grande majorité des entreprises étudiées sont caractérisées par un rapport entre investisseurs résidents et non-résidents tournant très nettement à l’avantage des premiers. On peut ainsi affirmer que les « multinationales » de la communication n’existent pas. Souhaitée par les uns ou redoutée par les autres, mais proclamée par tous, la « financiarisation » des industries culturelles n’a pas, en effet, débouché sur la trans-nationalisation du capital dont elle se voulait, pourtant, annonciatrice. Le « marché global » de l’information demeure, à ce jour, une vue de l’esprit séduisante, mais scientifiquement non fondée, les réseaux technologiques n’ayant pu transformer les capitalismes en un marché mondial faisant fi des principaux référentiels d’antan tels que ceux de « propriété », de « classes sociales » et de « souveraineté nationale ». Quant au pouvoir des grands actionnaires traditionnels (familles, pouvoirs publics, etc.), il n’a pas non plus cédé face à la pression des fonds d’investissements anglo-saxons, mais s’est au contraire consolidé à cette haute finance ayant permis le lancement d’opérations de fusion et acquisition, sans précédent jusque-là, dans le secteur de la communication. La « globalisation » des réseaux informationnels ne s’identifie pas, enfin, à la régénérescence d’un libéralisme pur et parfaitement concurrentiel, mais à la réaffirmation de quelques-unes des caractéristiques les plus fondamentales des industries culturelles en régime capitaliste : concentration de la propriété des firmes, centralisation de l’économie nationale, fusion des intérêts bancaires et industriels, consolidation des principaux holdings et, enfin, imbrication des groupes financiers et de l’appareil d’Etat. On aurait tort cependant de se limiter à une approche strictement financière de ces phénomènes. La situation quasi monopolistique que connaissent certaines compagnies leaders dans le domaine de la presse ou des NTIC ne s’éclaire, en effet, véritablement qu’à la lumière de leur très forte centralité au sein des réseaux de pouvoir. La densité des relations que les firmes en question entretiennent avec l’appareil d’Etat, les principales entreprises industrielles et financières, et les plus influents groupes de pression et autres think tanks constitue à nos yeux la première des conditions garantissant la reproduction des positions dominantes occupées par ces sociétés privées sur leur marché respectif. Cette approche relationnelle du pouvoir économique est illustrée par la multiplicité des positions institutionnelles détenues par les dirigeants des entreprises médiatiques. Représentant autant de formes incarnées de relations sociales génériques entre Economie, Politique et Communication, les grands administrateurs, issus pour la plupart d’entre eux du secteur financier ou de la très haute fonction publique, peuvent être légitimement considérés, pour parler le langage un peu oublié d’un Gramsci, comme les intellectuels organiques de la fraction hégémonique du bloc au pouvoir. Ce qu’il faut, au total, rejeter dans la définition des médias en tant que « quatrième pouvoir » ou dans celle des réseaux numériques en tant que « nouveaux pouvoirs », c’est l’impensé théorique qui sous-tend cette représentation d’une industrie de la communication qui « globalisée », « libéralisée » et « dérégulée », se serait simultanément affranchie des territoires nationaux, des gouvernements et de la grande bourgeoisie d’affaires. Il n’est pas non plus conforme à la vérité des faits et de leur recoupement de penser que la classe dirigeante ne se servirait de la presse que comme vulgaire relais ou instrument de propagande. Tout semble plutôt se passer comme si le champ du pouvoir était invaginé dans le champ médiatique du fait de la circulation ininterrompue de certains agents sociaux privilégiés entre les divers sous-espaces constitutifs du champ du pouvoir (pouvoir économique, pouvoir d’Etat, pouvoir idéologique, etc.). [less ▲]

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See detailInfluence, information and item response theory in discrete data analysis
Magis, David ULg

Doctoral thesis (2007)

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See detailThe Problems and Challenges of Cambodian Rural Economy. Between New Governances and Peasant’s Realities. The Case of Kampong Thom Province
Diepart, Jean-Christophe ULg

Doctoral thesis (2007)

In Cambodia, agriculture and natural resources constitute a corner stone in the production systems of peasant families, who constitute the large majority of the rural population. Hence, in the perspective ... [more ▼]

In Cambodia, agriculture and natural resources constitute a corner stone in the production systems of peasant families, who constitute the large majority of the rural population. Hence, in the perspective of an important demographic growth and an increasing marketing of agricultural inputs and outputs, man-made management of ecosystems represent considerable economic, social and environmental challenges to Cambodian peasants. The study precisely focuses on the peasant’s ways to manage rural territories. It rests on a fundamental hypothesis, according to which peasant practices are environmentally sustainable, economically efficient (in terms of creation of added-values) and socially equitable in the distribution of these added-values. A multi-scale analytical framework that integrates different dimensions of natural resources management is established to check out and fine tune this fundamental hypothesis. A first analytical framework, given a priori, covers the entire province of Kampong Thom. The second analytical framework is determined by choice. It covers two communes, selected on the basis of agro-ecological and institutional criteria, which are representative of rural dynamics observed and detailed at the provincial level. The first part shows the intricate links between agro-ecological diversity and peasant’s production systems. It details the social relationships that liven up rural territories and shows how power relationships structure or affect peasant communities. The next part analyses the new choices for collective and individual action for the management of natural resources. It points out the very conflictive nature of previous forms of management and the internal contradictions of the new choices. The potential contribution of commune council in natural resources management is also examined from a legal and organisational point of view. Field works carried out at the level of two communes detail and complete this analysis. First of all, spatial analysis of land use change between 1992 and 2006 shows the growing importance of non-peasant stakeholders in rural development dynamics. The analysis shows that when the development of rural territories can be entirely controlled by peasant’s communities, the dynamics of change are rational and efficient. Peasant’s strategies are characterized by a large diversity of activities, that all have in common the cultivation of rain-fed rice. The access to forest or fisheries resources on public state land is triggered by household’s activities diversification tactics in the dry season. These modes of access and use of natural resources are critically detailed and put in the perspective of the establishment of community fisheries and community forestry schemes. Management of private agricultural land is characterized by the overwhelming importance of rice in the cropping systems. Technical itineraries for rice cultivation implemented by rural households are analyzed and their economic results are evaluated. Different economic rationalities are highlighted in relation to inputs productivity. Elements of productivity, efficiency and profitability are also apprehended in relation with the access to credit and land markets. This analysis allows revisiting the assumed self-regulating role of land markets to ensure the growth of the agricultural sector on the one hand, and the improvement in the access of land for more equity on the other hand. Eventually, the analysis done at the commune level are put into the perspective of new institutional choices for collective and individual action for natural resources management and propose, in fine, operational recommendations to support peasant’s ways to manage natural resources. [less ▲]

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See detailMathematical modeling of bone regeneration during fracture healing and implant osseointegration
Geris, Liesbet ULg

Doctoral thesis (2007)

Despite the extensive body of literature on bone regeneration, many questions remain on e.g. the regulatory mechanisms and potential treatment strategies of pathological regeneration cases. The hypothesis ... [more ▼]

Despite the extensive body of literature on bone regeneration, many questions remain on e.g. the regulatory mechanisms and potential treatment strategies of pathological regeneration cases. The hypothesis underlying this work states that mathematical models of bone regeneration can make a substantial contribution to this domain by proposing pathological regeneration mechanisms and designing therapies, which can subsequently be tested experimentally. In the first part of this work, existing mechanoregulatory and bioregulatory models of bone regeneration are implemented and applied to both implant osseointegration and fracture healing set-ups. A quantitative comparison with experimental results is performed. Thorough sensitivity analyses are carried out to assess the influence of various modelling aspects on the simulation outcome. Shortcomings of these models are identified and suggestions for improvements are made. In the second part of this work, a novel bioregulatory model of bone regeneration is developed in which several of the previously defined shortcomings are addressed. This model includes key aspects of the regeneration process such as intramembranous and endochondral ossification, angiogenesis and directed cell motion. The results obtained with this novel model are corroborated both qualitatively and quantitatively by comparison with experimental data for normal fracture healing. Cases of pathological fracture healing are simulated and experimentally testable therapeutic strategies are implemented. The last part of this work describes the establishment of a mathematical framework, based on the previously developed bioregulatory model, in which the regulatory influence of both biological and mechanical factors is combined. This is the first model of bone regeneration in which the coupling between mechanical loading and angiogenesis is made in an explicit and mechanistic manner. Several examples are given to illustrate the added value of this approach in simulating normal and pathological bone regeneration. In summary, this work demonstrates the potential of mathematical models in advancing the knowledge on bone regeneration and designing treatment strategies for pathological healing cases. [less ▲]

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See detailInversion of probabilistic models of structures using measured transfer functions
Arnst, Maarten ULg

Doctoral thesis (2007)

The aim of this thesis is to develop a methodology for the experimental identification of probabilistic models for the dynamical behaviour of structures. The inversion of probabilistic structural models ... [more ▼]

The aim of this thesis is to develop a methodology for the experimental identification of probabilistic models for the dynamical behaviour of structures. The inversion of probabilistic structural models with minimal parameterization, introduced by Soize, from measured transfer functions is in particular considered. It is first shown that the classical methods of estimation from the theory of mathematical statistics, such as the method of maximum likelihood, are not well-adapted to formulate and solve this inverse problem. In particular, numerical difficulties and conceptual problems due to model misspecification are shown to prohibit the application of the classical methods. The inversion of probabilistic structural models is then formulated alternatively as the minimization, with respect to the parameters to be identified, of an objective function measuring a distance between the experimental data and the probabilistic model. Two principles of construction for the definition of this distance are proposed, based on either the loglikelihood function, or the relative entropy. The limitation of the distance to low-order marginal laws is demonstrated to allow to circumvent the aforementioned difficulties. The methodology is applied to examples featuring simulated data and to a civil and environmental engineering case history featuring real experimental data. [less ▲]

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See detailFunctionalization of poly(ε-caprolactone) and its macromolecular engineering
Riva, Raphaël ULg

Doctoral thesis (2007)

Macromolecular engineering is one of the most powerful tools to control the molecular parameters, including architecture of polymers, and to improve their performances or to impart them new properties ... [more ▼]

Macromolecular engineering is one of the most powerful tools to control the molecular parameters, including architecture of polymers, and to improve their performances or to impart them new properties. This contribution aims at reporting on a novel strategy for the macromolecular engineering of poly-ε-caprolactone (PCL) which is based on the use of functional ε-caprolactone, the α-chloro-ε-caprolactone (αClεCL). Indeed, αClεCL is a precursor of polymers and copolymers with εCL that bear pendant activated chlorides well suited to “grafting from” reaction. These (co)polyesters have been used as macroinitiators for the Atom Transfer Radical Polymerization (ATRP) of methyl methacrylate leading to the corresponding graft copolymer. They have also been involved in an Atom Transfer Radical Addition (ATRA) reaction with a series of olefins bearing different functional groups (hydroxyl, carboxylic acid and epoxy group) in order to functionalize the polyester backbone without deleterious degradation. ATRA of PEO chains with an unsaturation end groups has also been carried out in order to prepare PCL-g-PEO of different compositions to be used as stabilizers of polyester nanoparticles. Combination of ring-opening polymerization of ε-caprolactone and the copper-catalyzed Huisgen’s [3+2] cycloaddition is a novel strategy for going a step further in the macromolecular engineering of poly-ε-caprolactone (PCL). This ‘click” reaction is very well-suited to the chemical modification of aliphatic polyesters because, its implementation under very mild conditions prevents chain degradation from occurring. Indeed, alkynes were cycloadded onto azide containing PCL at low temperature (35°C) in an organic solvent (DMF or THF). Originally, α-chloro-ε-caprolactone and ε-caprolactone were randomly copolymerized in toluene at room temperature followed by reaction of the activated chlorides with sodium azide. In order to make a wide range of functional aliphatic polyesters available, poly(α-azide-ε-caprolactone-co-ε-caprolactone) copolyesters were reacted with a series of alkynes substituted by a functional group, e.g., hydroxyl, acrylate and quaternary ammonium salts, This strategy turned out to be efficient to synthesize for instance hydrophilic, photo-cross-linkable and hydrosoluble PCL. Moreover, a variety of graft copolymers were prepared by both the “grafting from” and the “grafting onto” techniques. Indeed, an ATRP initiator was attached onto PCL followed by polymerization of vinyl monomers, whereas alkyne end–capped PEO was cycloadded onto azide-containing PCL with formation of amphiphilic PCL-g-PEO copolymers. Last but not least, the “click” chemistry was very instrumental in imparting an antimicrobial activity to PCL or for the preparation of new functionalized caprolactones. [less ▲]

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See detailEngineering RNA-mediated resistance to geminiviruses in cassava
Vanderschuren, Hervé ULg

Doctoral thesis (2007)

Cassava mosaic disease (CMD) is the most important disease affecting cassava in Africa. The disease is caused by several whitefly-transmitted geminivirus species. The increasing impact of geminivirus ... [more ▼]

Cassava mosaic disease (CMD) is the most important disease affecting cassava in Africa. The disease is caused by several whitefly-transmitted geminivirus species. The increasing impact of geminivirus-caused diseases on cassava production due to the recent pandemics has urged the scientific community to provide stable virus resistance in cassava. Advances in engineering virus resistance via RNA-based strategies have opened promising perspectives for the production of transgenic geminivirus resistant plants. In this thesis, three RNA-based strategies are developed to improve the resistance to African cassava mosaic virus (ACMV) in transgenic cassava. The first strategy was based on expression of antisense viral sequences. Three different viral coding sequences were targeted and several transgenic cassava lines expressing antisense viral sequences were ACMV resistant. The second strategy was to express intron hairpin double-stranded RNAs (dsRNAs) homologous to ACMV bidirectional Promoter. Transgenic cassava lines expressing small dsRNAs homologous to the ACMV promoter were not completely immune to ACMV infection but showed an enhanced recovery phenotype as cornpared to the infected wild-type cassava plants. The third strategy relied on the expression of intron hairpin dsRNAs homologousto viral coding sequences. Transgenic cassava lines expressing high levels of small RNAs homologous to the viral coding sequences were immune under ACMV infection tests in which virus load had been sufficient to break resistance elaborated with the first two strategies. This work demonstrated that ACMV resistance could be achieved in cassava via an RNA-based approach and that the strategy used (i.e. antisense RNA, hairpin dsRNA against non-coding viral sequence, hairpin dsRNA against viral coding sequences) had an impact on the resistance level. [less ▲]

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See detailMacromolecular engineering of cyclic aliphatic polyesters
Li, Haiying

Doctoral thesis (2007)

This works aims at reporting a novel strategy that combines the controlled ring-opening polymerization of lactones initiated by a cyclic tin(IV) dialkoxide and intramolecular cyclization by photo-cross ... [more ▼]

This works aims at reporting a novel strategy that combines the controlled ring-opening polymerization of lactones initiated by a cyclic tin(IV) dialkoxide and intramolecular cyclization by photo-cross-linking of pendant unsaturations next to the propagating sites. No linear species is ever involved in the polymerization, which allows higher molecular weight macrocycles to be prepared with high efficiency. Moreover, the synthetic route is very flexible to the point where macrocyclic polyesters with more complex although well-defined architectures, such as tadpole-shaped and sun-shaped copolyesters, can be tailored. Synthesis of well-defined star- and eight-shaped polyesters and twin tadpole-shaped amphiphilic copolymers has also been explored by using a spirocyclic tin(IV) alkoxide as an initiator. [less ▲]

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See detailEpic Proportions: Post-Epic Verse-Novels and Postcolonial Critique
Burkitt, Katharine ULg

Doctoral thesis (2007)

My thesis is based on the premise that verse-novels occupy a marginalised and contested position in contemporary literature: as they tread the generic boundaries of poetry and prose writing, they are ... [more ▼]

My thesis is based on the premise that verse-novels occupy a marginalised and contested position in contemporary literature: as they tread the generic boundaries of poetry and prose writing, they are always marked by their incongruous nature. This makes for uncomfortable reading as expectations are disrupted and undermined, and, for the poet, the adoption of the verse-novel form becomes both a risky and consciously political move. Each of the verse-novels that I consider is self-conscious of its anomalous generic affiliations and utilises them in order to replicate the postcolonial politics of the text. These texts all engage with the verse-novel form in different ways and draw attention to its problematic and marginal nature. This is used to highlight their postcolonial nature, as they are all concerned with matters of racial and national identity in a world where these categories are complicated. The commonality in these works is their relationships with epic form, in this thesis I identify this as a post-epic mode of writing. My study is based on the relationship between poetic form and postcolonial critique; it focuses upon three texts: the Australian poet Les Murray’s Fredy Neptune, the Canadian poet Anne Carson’s Autobiography of Red, and British writer Bernardine Evaristo’s The Emperor’s Babe. These texts and their authors call for a reconsideration of postcolonialism; this is both demonstrative of a conceptual shift towards global notions of identity, whilst also being problematic in terms of the political commitment of the texts. Each of these works demonstrates an awareness of the contradictory nature of their positions as they shy away from utopian visions. In line with this, my aim is to demonstrate the way in which the self-reflexive employment of experimental poetry compliments an engagement with the transformative aspect of contemporary postcolonial politics. [less ▲]

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See detailPlanification stratégique de Systèmes de transport de marchandises en Europe : Modèles de localisations optimales de hubs de conteneurs sur un réseau multimodal
Limbourg, Sabine ULg

Doctoral thesis (2007)

There is a growing imbalance between modes of transport in the European Union. The increasing success of road results in an ever worsening congestion, more environmental nuisances and accidents. That’s ... [more ▼]

There is a growing imbalance between modes of transport in the European Union. The increasing success of road results in an ever worsening congestion, more environmental nuisances and accidents. That’s why one of the objectives of the European Common Transport Policy is to restore the balance between modes of transport and to develop intermodality. Among the various types of intermodal transport this doctoral dissertation is concerned by rail-road combined transport for which the terminals are embedded in a hub-and-spoke network. This kind of topology can reduce the transportation costs by consolidations at the hubs. The proposed method uses the flows of commodities and their geographic spreading as input to determine a set of good potential locations for transfer container terminals. This set can further be used as input for an iterative procedure based on both the p-HMP and the multi-modal assignment in order to identify the optimal locations for such terminals in Europe. This procedure takes into account the variation of the transshipment cost according to the number of containers that could be transshipped. [less ▲]

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See detailL'homologation judiciaire des conventions. Essai d'une théorie générale.
Moreau, Pierre ULg

Doctoral thesis (2007)

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See detailMesure et analyse du transport advectif de CO2 dans une forêt sur versant
Heinesch, Bernard ULg

Doctoral thesis (2007)

The micrometeorological technique of eddy-covariance is used for the estimation of the CO2 exchange between the ecosystems and the atmosphere. Hundreds of instrumented sites, spread all over the world ... [more ▼]

The micrometeorological technique of eddy-covariance is used for the estimation of the CO2 exchange between the ecosystems and the atmosphere. Hundreds of instrumented sites, spread all over the world, use it henceforth to study a great variety of ecosystems. This technique is however affected by a systematic error when applied above tall canopies like forests, in stable atmospheric conditions, i.e. primarily during non windy nights without cloud cover. Indeed, during these periods the turbulent transport would be competed with by another transport mechanism which is called advection. In this work, the presence of advection has been tested on the experimental forested site of Vielsalm (Belgium) and its importance has been evaluated. For this purpose, an experimental set-up allowing the measurements of wind velocity, CO2 concentration and temperature of the air inside the forest has been installed. It has allowed the description, for the stable periods, of gravitational flows being carried out close to the ground due to the cooling of surfaces and the presence of a weak slope. These flows were shown to be responsible for advective CO2 transport. An uncertainty analysis has been carried out using dedicated measurement campaigns. It has conclude with the feasibility of measurements of vertical and especially horizontal CO2 gradients on the site but has shown that the greatest factor of uncertainty related to the estimate of the vertical velocity component above and in the forest. In spite of these uncertainties, a fine analysis of the gravitational episodes has made it possible to highlight a coherent mechanism linking the flow field and the CO2 concentration field and making it possible to better understand how CO2 could be transported laterally and vertically by the gravitational flows. Finally, the feasibility of a correction based on the estimate of the advective terms has been evaluated. It has been shown that uncertainties relating to advection were too important to make it possible to appreciably improve the night assessment of CO2 fluxes by means of this method. This one proves however interesting for better understanding the processes of transport at work in a forest cover. [less ▲]

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See detailElaboration d’outils méthodologiques et techniques d’aide à la conception d’ambiances urbaines de qualité pour favoriser le développement durable des villes
Reiter, Sigrid ULg

Doctoral thesis (2007)

This PhD thesis develops methodological and technical tools aiding in the design of urban environments from the architectural, microclimatic and acoustic points of view.

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See detailAnalyse inverse en géotechnique : développement d’une méthode à base d’algorithmes génétiques
Levasseur, Séverine ULg

Doctoral thesis (2007)

La plupart des essais géotechniques in situ ne permettent pas d’identifier directement les paramètres constitutifs des couches de sol. L’utilisation de calculs par éléments finis pour dimensionner les ... [more ▼]

La plupart des essais géotechniques in situ ne permettent pas d’identifier directement les paramètres constitutifs des couches de sol. L’utilisation de calculs par éléments finis pour dimensionner les ouvrages est ainsi limitée par une mauvaise connaissance des propriétés mécaniques des sols. C’est dans ce contexte que se pose la problématique d’analyse inverse en géotechnique : quelles informations concernant les paramètres constitutifs du sol est-il possible d’obtenir à partir de mesures in situ? Ce travail concerne l’identification des paramètres de modèles constitutifs de sols par analyse inverse. Afin d’avoir une méthode d’identification adaptable à tout type de mesures (essais in situ ou ouvrages instrumentés), une méthode directe de résolution du problème inverse est développée. Des valeurs a priori sont données aux paramètres inconnus pour simuler le problème direct associé, à l’aide du code de calcul par éléments finis jusqu’à ce que l’écart entre les résultats du calcul numérique et les mesures in situ soit minimal. Les principales approches utilisées dans la littérature pour résoudre des problèmes d’optimisa- tion sont basées sur des méthodes de gradient. Ces méthodes supposent l’unicité de la solution du problème inverse. Or, les erreurs de modélisation et les incertitudes de mesures sont importantes en géotechnique. Il n’existe donc pas de solution exacte pour le problème inverse mais plutôt une infinité de solutions approchées. L’objectif de ce travail est de développer une méthode d’analyse inverse permettant d’identifier l’ensemble de ces solutions. Pour cela, nous avons choisi de baser la procédure d’analyse inverse sur un processus d’optimisation par algorithme génétique. Cette méthode, robuste et efficace, est connue pour sa capacité à résoudre des problèmes complexes. Nous montrons dans cette étude que l’analyse des solutions estimées par l’algorithme informe également sur la sensibilité des paramètres d’un modèle et sur l’existence possible de relations mathématiques entre ces paramètres. Suite à cela, nous proposons de décrire mathématiquement l’ensemble des solutions identifiées par l’algorithme génétique grâce à une étude statistique de type analyse en composantes principales. Cette étude montre que même si toutes les solutions d’un problème ne sont pas identifiées directement par l’algorithme génétique, leur exploitation par une analyse en composantes principales permet d’estimer l’ensemble des solutions du problème inverse. Cette méthode est développée à partir de quelques résultats obtenus sur des exemples synthétiques d’ouvrages de soutènement et d’essais pressiométriques. Puis, différentes applications réelles sur ces types d’essais et d’ouvrages géotechniques illustrent la pertinence de la méthode. [less ▲]

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See detailÊtre et jugement : étude sur la théorie des catégories dans la philosophie de Rickert
Dewalque, Arnaud ULg

Doctoral thesis (2007)

L'objectif de ce travail est de se réapproprier la contribution de Heinrich Rickert au programme critique de fondation de l'ontologie. Il est apparu que cette contribution résidait dans l'analyse des ... [more ▼]

L'objectif de ce travail est de se réapproprier la contribution de Heinrich Rickert au programme critique de fondation de l'ontologie. Il est apparu que cette contribution résidait dans l'analyse des structures formelles du jugement et, plus exactement, dans l'analyse du jugement existentiel. À la suite de Rickert, il a fallu déployer cette analyse sur deux versants: le versant noétique ou la théorie des actes judicatifs (Der Gegenstand der Erkenntnis, 1892-1928) et le versant noématique ou la théorie des propositions - ou "teneurs" - judicatives (Die Logik des Prädikats und das Problem der Ontologie, 1930). J'ai montré que cette double analyse permet non seulement de dégager deux concepts formels de l'être (l'être comme "Jaform" et comme "Urprädikat"), mais aussi de jeter les bases d'une théorie des catégories embrassant à la fois les étants sensibles et les étants non sensibles. [less ▲]

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See detailControl of radical reactions by transition-metal complexes
Richel, Aurore ULg

Doctoral thesis (2007)

The overall goal of this Ph.D. is to contribute to the conception, the synthesis and the characterisation of original homogeneous ruthenium-based catalytic systems (or heterobimetallic ruthenium-titanium ... [more ▼]

The overall goal of this Ph.D. is to contribute to the conception, the synthesis and the characterisation of original homogeneous ruthenium-based catalytic systems (or heterobimetallic ruthenium-titanium systems), highly active and effective towards atom transfer radical addition (ATRA) and polymerisation (ATRP) of several representative vinyl monomers. As catalytic performances may be tuned by the nature and the structure of the ligands around the metallic core, we are intending to systematically elucidate (by NMR and electrochemistry) the relations between stereoelectronic ligands parameters and the catalytic activity. Microwave irradition is also considered as an unexpected heating source for performing radical reactions. [less ▲]

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See detailMax Frisch. Uwe Johnson. Eine literarische Wechselbeziehung
Letawe, Céline ULg

Doctoral thesis (2007)

Detailed reference viewed: 17 (2 ULg)
See detailClosed-Loop Learning of Visual Control Policies
JODOGNE, Sébastien ULg

Doctoral thesis (2006)

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See detailEtude en temps réel du processus d'extraction de la tagitinine C en fonction des caractéristiques physico-chimiques du CO2 supercritique à l'aide de fibres optiques couplant un spectrophotomètre IRTF à un extracteur à fluide supercritique
Ziemons, Eric ULg

Doctoral thesis (2006)

L’extraction par fluide supercritique fait partie des nouvelles techniques de préparation d’échantillons solides qui ont émergé au cours de ces dernières années. Elle constitue une alternative ... [more ▼]

L’extraction par fluide supercritique fait partie des nouvelles techniques de préparation d’échantillons solides qui ont émergé au cours de ces dernières années. Elle constitue une alternative intéressante aux techniques classiques d’extraction liquide-solide car le pouvoir solvant du fluide supercritique est ajustable, non seulement par la température, mais aussi par la pression. L’extraction par le CO2 supercritique de la tagitinine C, lactone sesquiterpénique photo sensible à l’activité anti-inflammatoire, anti-malarique et anticancéreuse à partir des parties aériennes de Tithonia diversifolia constituait une application intéressante de ce procédé et a été sélectionnée comme molécule cible dans le cadre de ce travail. Son optimisation a impliqué des dosages répétés de l’analyte dont la vibration d’élongation de la fonction diénone absorbe intensément à des fréquences particulières dans le domaine de l’infrarouge. Aussi, avons-nous tout d’abord développé et validé, dans la première partie de ce travail, une technique IRTF d’analyse en différé sélective, rapide, non destructrice et sensible fondée sur ses propriétés. Les différents paramètres (température, pression, quantité de CO2, granulométrie de l’échantillon) influençant le rendement d’extraction de l’analyte ont pu être étudiés à cette occasion. Dans les conditions optimales, nous avons montré que l’extraction par le CO2 supercritique extrayait rapidement et avec une meilleure sélectivité la tagitinine C tout en conservant un taux de récupération comparable aux techniques classiques d’extraction. Parallèlement à ces travaux et compte tenu de la photo-dégradation de la tagitinine C en tagitinine F, la formation de complexes d’inclusion avec la β, 2,6-di-O-méthyle-β et la -cyclodextrine a été investiguée. Différentes techniques ont été employées pour caractériser les complexes formés au niveau de la stœchiométrie, de la constante de formation et de la structure. Aucun effet photo-protecteur significatif n’a été démontré avec la β et la -cyclodextrine. En revanche, nous avons mis en évidence une diminution de la vitesse de la photo-dégradation en présence de la 2,6-di-O-méthyle-β-cyclodextrine. Malheureusement, celle-ci reste trop limitée pour envisager l’utilisation de cette cyclodextrine pour éviter la dégradation de la tagitinine C lors de son exposition à la lumière directe. Dans la dernière partie de notre travail, nous nous sommes plus particulièrement focalisés sur l’interfaçage EFSC/IRTF qui constituait un indéniable défi. Le développement de l’interfaçage a été réalisé à l’aide de fibres optiques en chalcogène d’arsenic entre un extracteur à fluide supercritique et un spectrophotomètre IR et a ainsi permis d’effectuer le dosage en ligne de la tagitinine C dans le CO2 supercritique après passage de celui-ci au travers d’une cartouche d’extraction contenant la matrice végétale. Par ailleurs, le développement de cet outil répond parfaitement aux nouvelles approches (Process and Analytical Technology) préconisées par la FDA. Le processus d’extraction de l’analyte a pu dès lors être étudié de manière approfondie et en temps réel en fonction des caractéristiques physico-chimiques du fluide supercritique et de la durée de l’extraction. L’utilisation de la vibration d’élongation CH comme marqueur a permis de mettre en évidence l’obtention d’extraits de composition variable qui pourront être utilisés directement dans des études d’efficacité thérapeutique. Enfin, la méthode d’extraction et de dosage en ligne de la tagitinine C a fait l’objet d’une validation poussée selon la nouvelle approche faisant appel aux profils d’exactitude dans un intervalle de dosage allant 500 à 2500 µg. Sur la base des différents profils d’exactitude obtenus, le modèle de régression linéaire a été choisi pour décrire la relation concentration-réponse. En effet, ce modèle présentait des valeurs de biais relatif inférieures à 2%, des valeurs de coefficient de variation ne dépassant pas 4% et des limites de tolérance comprises dans les limites d’acceptation de ±15% sur toute la gamme de concentration. De plus, le modèle de régression linéaire était en parfaite adéquation avec la méthode des ajouts dosés. [less ▲]

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See detailQuantifications naturelles projectivement équivariantes
Radoux, Fabian ULg

Doctoral thesis (2006)

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See detailMolecular and cellular insights into IKAP and Elongator functions
Close, Pierre ULg

Doctoral thesis (2006)

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See detailOptimisation objective de paramètres en écoulements turbulents à surface libre sur maillage multibloc
Erpicum, Sébastien ULg

Doctoral thesis (2006)

The chronology of the theoretical and numerical researches outlined in this text is closely linked to our attachment to the physical modelling and to the practical concerns related to important hydraulic ... [more ▼]

The chronology of the theoretical and numerical researches outlined in this text is closely linked to our attachment to the physical modelling and to the practical concerns related to important hydraulic projects. The various applications carried out daily in the HACH , several of the being presented here, enabled to identify the ways to improve the existing numerical models of WOLF , as well as needs in new representation potentialities. The most of the developments described in this text were born from there, with as main objective to increase the capacities of the HACH’s models to help to the management and the design of hydraulic constructions. The hydraulic structures design, and the main part of the practical problems related to free surface flows hydrodynamics, requires both large and small scales studies, with reliable models locally suited to the represented phenomena, and thus variable in a single study depending on the particular point examined. On another hand, the shape and working optimization of hydraulic structures requires robust calibration tools allowing an objective approach. The latter have to be linked to simulation software with modelling capacities and computation times in agreement with the optimization requirements. Both these assessments specify the framework of the researches of this thesis and are at the roots of the definition of the objectives of this work. The first chapters of developments aim to describe the numerical framework of the WOLF package, and more particularly the 1D and 2D models. The rationalization of the computation times for large scale one-dimensional simulations is improved at this stage by implementing in the 1D solver an implicit time integration scheme in parallel to the existing explicit one. Similarly, some improvements have been brought to the solver WOLF2D. They concern the automatic extension of the computation domain regarding the wet and dry cells, the treatment of the slope and roughness source terms with an energetic approach, the water volume conservation as well as the reorganization of the equations resolution scheme in order to be totally free in the choice of the mathematical model to solve. The enrichment of the modelling potentialities of the WOLF software is then pursued by setting, implementing and applying an original turbulence model suited to the specific characteristics of the depth integrated flow modelling. In order to get over the computer and modelling limitations inherent in the use of a single mesh size to model a 2D domain, developments have been carried out to allow the realisation of two-dimensional computations on a structured Cartesian grid composed of several areas with different mesh sizes. In the same way, developments have been carried out to use the whole of the mathematical models available in WOLF2D simultaneously and automatically in a single simulation. The ultimate step of these developments consisted in linking the 1D and the 2D models in a single computation. Following all these steps of developments of hydrodynamic models, a suitable tool for parameters automatic calibration has been set up. Usable with any solver of the WOLF package, it allows the calibration of the whole of the physical parameters present in the hydrodynamic solvers, as well as the resolution of any calibration or optimization problem with these models. The final parallelisation of this Genetic Algorithms based tool opens the door to complex applications, such as the hydraulic design of structures on the basis of two-dimensional simulations of free surface turbulent flows on multiblock grid. At each step, the validation of the developments is rigorously performed through the comparison of the numerical results with those from test cases, theoretical or experimental, original or from the literature. Several practical applications examples illustrate the whole of the developed modelling potentialities and prove their applicability and efficiency facing the most of practical problems encountered by hydraulic engineers. [less ▲]

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See detailDéveloppement de modèles analytiques pour la prédiction du comportement élastique des assemblages mécaniques à broches dans la construction en bois
Ly, Dong Phuong Lam ULg

Doctoral thesis (2006)

A general procedure for the evaluation of the mechanical properties of structural joints, named “component method”, is now available from intensive research works at the European level. This procedure ... [more ▼]

A general procedure for the evaluation of the mechanical properties of structural joints, named “component method”, is now available from intensive research works at the European level. This procedure allows the analytical prediction of the resistance, but also of the stiffness and the deformation capacity, of structural joints under external forces (axial or shear forces, bending moments …). The component method is nowadays integrated as a reference procedure in two European de-sign codes, respectively for steel structures (EC3 [EN1993]) and steel-concrete composite structures (EC4 [EN1994]). However, its potential scope is much larger and present studies are aimed to apply to situations as joints in fire, joints under seismic loading, joints under exceptional loads (Robustness Project) …. More recently, a research project [CTI-2004] has succeeded in applying the component method to the investigation of the elastic behaviour of mechanical joints in timber construction. That is the result of the collaboration of CTIB-TCHN (Belgian Institute for Wood Technology) and University of Liège. The main principle of the component method is the following: • identification of constitutive components subjected to tension, compression or shear in the joint; • determination of the mechanical behaviour of these individual components; • "assembling" components so as to derive the mechanical properties of the whole joint. In the present paper, timber joints with dowel fasteners are considered. Two components may be identified: • "dowel" component (dowel fastener in bending and shear); • embedding component (timber member in embedding). The "dowel" component is known from past researches, whereas little information is available for the embedding component. EC5 [EN1995] proposes formulation to predict the behaviour for joints composed of these two components; but it only depends on two factors: the dowel diameter and the timber density. The influence probably significant of the grain direction (material strongly anisotropy) and the thickness of the connected members are for instance neglected. Experimental, numerical and analytical investigations have recently been performed by Uni-versity of Liège in collaboration with CTIB-TCHN so as to propose another formulation more precise for joints. Experimental results, performed by CTIB-TCHN, have been used as refer-ence for the development of numerical model and, then, analytical model. The application of the component method to the prediction of the elastic behaviour of timber joints consist of two steps: • "local" investigation on components that is to develop analytical models for the pre-diction of the elastic behaviour of components; • "global" investigation on joints that is to develop analytical models for the prediction of the elastic behaviour of joints. The application of the component method to timber joints with dowel fasteners is a first step towards the use of this concept in future to others mechanical joints (screw, punched metal plate, nail, bolt …). In this case, others components may be derived to cover the field of ap-plication expected. [less ▲]

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See detailImproving Public Outcomes in Developing Countries. Application of Incentive Theory to Foreign Aid and Public Resource Management
Paul, Elisabeth ULg

Doctoral thesis (2006)

This Ph.D. thesis applies incentive theory – and especially, when relevant, the principal-agent theory – to several aspects of public resource management in developing countries. It uses analytical models ... [more ▼]

This Ph.D. thesis applies incentive theory – and especially, when relevant, the principal-agent theory – to several aspects of public resource management in developing countries. It uses analytical models taking account of realistic constraints of these economies. The first part of the dissertation studies the incentive problems associated with foreign aid management. The second part deals with some “domestic” problems linked with public resource management in those countries. Chapter 2 proposes an analytical framework to guide the design of public expenditure management systems (more precisely, the type of controls a Ministry of Finance could apply to line ministries) according to country-specific parameters. Chapter 3 suggests that, when traditional incentives (sanctions and rewards) fail – which may be the case, at least in the short run, in many developing countries) – increasing public affairs transparency can help improve public outcomes, notably through relying on "informal" accountability systems. Chapter 4 reviews the literature and then draws some important results as to the motivation of public agents. In addition to specific results on the issues targeted in each chapter, this dissertation offers a coherent analytical picture of public resource management in developing countries, and a number of general lessons may be drawn. Improving public outcomes must indeed pass through providing public agents with adequate incentives, so as to align their interests with their principal’s. Different tools may be used, depending on their cost-effectiveness: e.g., controls, incentive premiums, factors acting on non-materialistic motivations or on informal accountability mechanisms. The thesis also proposes some lessons as to the sequencing of reforms dealing with public resource management. [less ▲]

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See detailReconstruction of the 1979-2005 Greenland ice sheet surface mass balance using satellite data and the regional climate model MAR
Fettweis, Xavier ULg

Doctoral thesis (2006)

In order to improve our knowledge on the current state and variability of the Greenland ice sheet surface mass balance (SMB), a 27-year simulation (1979-2005) has been performed with the coupled ... [more ▼]

In order to improve our knowledge on the current state and variability of the Greenland ice sheet surface mass balance (SMB), a 27-year simulation (1979-2005) has been performed with the coupled atmosphere-snow regional model MAR. This simulation reveals an increase in the main factors of the SMB which are, on the one hand, the snowfall (+ 1.6 ± 1.8 km3 yr-1) in winter and on the other hand, the run-off (+ 4.2 ± 1.9 km3 yr-1) in summer. The net effect of these two competing factors leads to a SMB loss rate of – 2.7 ± 3.0 km3 yr-1, which has a significance of 87%. The melt extent derived from the passive microwave satellite data since 1979 also shows this trend. The melt water supply has increased because the Greenland ice sheet has been warming up by + 0.09 ± 0.04 °C yr-1 since 1979. This warming comes from a uniform increase of downward infra-red radiation which can not be explained by the natural variability. These changes result very likely from the global warming induced by human activities. As a result, it seems that: i) increased melting dominates over increased accumulation in a warming scenario, ii) the Greenland ice sheet has been significantly losing mass since the beginning of the 1980's by an increasing melt water run-off as well as by a probable increase of iceberg discharge into the ocean due to the "Zwally effect" (the melt water-induced ice sheet flow acceleration) and iii) the Greenland ice sheet is projected to continue to lose mass in the future. The Greenland ice sheet melting could have an effect on the stability of the thermohaline circulation (THC) and the global sea level rise. On the one hand, increases in the freshwater flux from the Greenland ice sheet (glacier discharge and run-off) could perturb the THC by reducing the density contrast driving it. On the other hand, the melting of the whole Greenland ice sheet would account for a global mean sea level rise of 7.4 m. [less ▲]

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