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See detailThe Mediation Service, what interest for emergencies?
PIAZZA, Justine ULg; BRASSEUR, Edmond ULg; DOPPAGNE, Caroline ULg et al

Poster (2015, January 17)

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See detailCancer metabolism reprogramming in response to anti-angiogenic therapy
Sounni, Nor Eddine ULg

Poster (2015, January 15)

In this study, we have explored the tumor adaptation to antiangiogenic therapy with the multitarget receptor tyrosine kinase inhibitors (RTKIs) Sunitinib and sorafenib. These RTKIs are currently in ... [more ▼]

In this study, we have explored the tumor adaptation to antiangiogenic therapy with the multitarget receptor tyrosine kinase inhibitors (RTKIs) Sunitinib and sorafenib. These RTKIs are currently in clinical use for multiple tumor types and confer increased overall or progression-free survival. However, antiangiogenic drugs demonstrate only relatively modest survival benefits and transient responses to treatment. Furthermore, preclinical studies suggest that RTKIs withdrawal results in accelerated tumor progression and metastasis. By applying the RTKIs treatment to 5 preclinical models of cancer development with global screening technologies, we found that tumors shift their metabolism during antiangiogenic therapy and acquire more aggressive phenotype after treatment cessation. We found that accelerated tumor growth and metastasis upon RTKIs withdrawal was associated with decreased glucose metabolism, increased lipid metabolism, and activation of the tricarboxylic acid (TCA) cycle. In particular, withdrawal of RTKIs resulted in elevated levels of fatty acid synthase (FASN) and acetyl-CoA carboxylase and adipocyte accumulation in tumors. Antiangiogenic therapy induced a metabolic shift in cancer and stromal cells to a glycolytic and hypoxic state during treatment, which was reversed upon therapy withdrawal, resulting in a shift to de novo lipogenesis and increased TCA cycle activity to promote tumor regrowth. Targeting lipid metabolism using the FASN inhibitor orlistat or by specific knockdown of FASN suppressed the RTKIs withdrawal–associated tumor regrowth and metastasis. We will discuss the role for lipid metabolism in tumor adaptation to antiangiogenic therapy withdrawal. [less ▲]

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See detailFIRST, a fibered aperture masking instrument: Results of the Lick observing campaign
Bordwell, Baylee; Duchene, Gaspard; Huby, Elsa ULg et al

Poster (2015, January 01)

FIRST is a prototype instrument aimed at achieving high dynamic range and angular resolution in ground-based images at visible wavelengths near the diffraction limit. FIRST utilizes an aperture masking ... [more ▼]

FIRST is a prototype instrument aimed at achieving high dynamic range and angular resolution in ground-based images at visible wavelengths near the diffraction limit. FIRST utilizes an aperture masking-like technique that makes use of single-mode fibers and pupil remapping to maximize the area of the telescope mirror in use. While located at Lick observatory in 2011 and 2012, FIRST observed 25 binary systems with the Shane 3m telescope, with separations ranging from 20 to 200 mas, comparable to the 50 mas diffraction limit for our central wavelength. Huby et al. (2013) has reported results for the Capella system that established the utility of FIRST for characterizing stellar binaries using the directly measured spectral flux ratio. Using an improved data analysis pipeline, we obtained closure phase measurements for a majority of the targets observed at Lick, and derived angular separations and spectral flux ratios. From the spectral flux ratios we obtained spectra for the companions over at least 600-850 nm with R~300. Finally, by obtaining results for many binary systems we have better constrained the current performance of FIRST, which has an exciting future ahead at its current location behind SCExAO at the Subaru 8.2 m telescope, where it will eventually become available for general use by the astronomical community. [less ▲]

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See detailL'adolescent diabétique et la tentation suicidaire
Malchair, Alain ULg

Poster (2015, January)

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See detailChange in the protofilamentnumber and β5-tubulin appearance in supporting cells during development of the hearing organ.
Renauld, Justine ULg; Thelen, Nicolas ULg; Johnen, Nicolas ULg et al

Poster (2015, January)

The supporting cells of the hearing organ are characterized by the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a ... [more ▼]

The supporting cells of the hearing organ are characterized by the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a minor mammalian tubulin, the β5-tubulin, recently reported as a biomarker of cell proliferation. It was shown that a β-tubulin isoform can specify the microtubule architecture, as seen with the expression of the Moth β2 tubulin in the Drosophila testes which imposes the 16-protofilament (16pf) structure on the corresponding subset of Drosophila microtubules. Moreover, supporting cell microtubules are formed by 15pf instead of the canonical 13, a unique fact among vertebrates. Such a protofilament configuration has been observed in C. elegans’ neurons which are responsible for the mechanosensory sense of touch. It was also shown that these 15pf microtubules were essential to the proper functioning of these neurons. To determine the role of this particular tubulin in the auditory organ and its possible involvement in the formation of the unusual 15pf microtubules of supporting cells, we studied the spatiotemporal localization of β5-tubulin during development in rats from embryonic day 18 until P25 (25th postnatal day). Then we examined the fine structure of microtubules at the transmission electron microscope level (TEM). Our results showed that β5-tubulin, contrary to other β-tubulins, had a unique distribution in the cochlea. This β-tubulin appeared at a postnatal stage, before the opening of the Corti’s tunnel and is restricted to supporting cells, especially in pillar and Deiters’ cells. Our TEM study further indicated that these cells were composed by 13pf microtubules at P2, but by 15pf microtubules at P25. In conclusion, the architecture and composition of microtubules present in the supporting cells change during development of the Corti organ. Further experiments are now required to determine if these changes are related to the appearance of β5-tubulin. [less ▲]

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See detailVariation of PTH and bone biomarkers in hemodialysis patients.
DELANAYE, Pierre ULg; Warling, X; Moonen, M et al

Poster (2015)

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See detailLe portrait des agricultrices wallonnes en 2014
Dogot, Thomas ULg; Du Faux, Judith

Poster (2015)

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See detailVery high resolution surface mass balance of Svalbard with the regional climate model MAR
Lang, Charlotte ULg; Fettweis, Xavier ULg

Poster (2015)

We present climate and surface mass balance (SMB) results over Svalbard simulated by a new version of the regional climate MAR model allowing to reach ∼km resolution without highly time-consuming runs ... [more ▼]

We present climate and surface mass balance (SMB) results over Svalbard simulated by a new version of the regional climate MAR model allowing to reach ∼km resolution without highly time-consuming runs. Spitsbergen, the largest island of the Svalbard archipelago, has a very hilly topography and, as the SMB strongly depends on the local topography and ice distribution, we need a high spatial resolution to accurately represent the SMB of Svalbard and its complex spatial distribution. However, higher resolution simulations are also very time consuming. That is why we have developed a new version of the MAR model in which the atmospheric module runs at a resolution of 7.5 km and the snow/ice module runs at a resolution of 3.75 km. Simulations over 1960-2014 forced by ERA show better agreement with SMB observations compared to our recent 10 km resolution recently published results. [less ▲]

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See detailCerebellar hemorrhage : a rare condition in the term infant
MERINDOL, Ninon; BROUX, Isabelle ULg; DECORTIS, Thierry et al

Poster (2015)

Cerebellar hemorrhage is a rare condition in full-term newborns. Early diagnosis based on the identification of risk factors, particular clinical signs and correct medical imaging is primordial to ... [more ▼]

Cerebellar hemorrhage is a rare condition in full-term newborns. Early diagnosis based on the identification of risk factors, particular clinical signs and correct medical imaging is primordial to optimize the immediate treatment and to assess the long term prognosis. [less ▲]

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See detailAssimilation of sea surface temperature, sea ice concentration and sea ice drift in a model of the Southern Ocean
Barth, Alexander ULg; Canter, Martin ULg; Van Schaeybroeck, Bert et al

Poster (2015)

Current ocean models have relatively large errors and biases in the Southern Ocean. The aim of this study is to provide a reanalysis from 1985 to 2006 assimilating sea surface temperature, sea ice ... [more ▼]

Current ocean models have relatively large errors and biases in the Southern Ocean. The aim of this study is to provide a reanalysis from 1985 to 2006 assimilating sea surface temperature, sea ice concentration and sea ice drift. In the following it is also shown how surface winds in the Southern Ocean can be improved using sea ice drift es- timated from infrared radiometers. Such satellite observations are available since the late seventies and have the potential to improve the wind forcing before more direct measure- ments of winds over the ocean are available using scatterometry in the late nineties. The model results are compared to the assimilated data and to independent measurements (the World Ocean Database 2009 and the mean dynamic topography based on observations). The overall improvement of the assimilation is quantified, in particular the impact of the assimilation on the representation of the polar front is discussed. Finally a method to iden- tify model errors in the Antarctic sea ice area is proposed based on Model Output Statistics techniques using a series of potential predictors. This approach provides new directions for model improvements. [less ▲]

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See detailDevelopment in Red River Delta, Vietnam
Nguyen Thi Minh Khué, ULg; Nguyen Thi, Dien; White, Ben et al

Poster (2015)

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See detailAir Capture and Power-to-Fuel to Close the Carbon Loop
Léonard, Grégoire ULg; Villarreal-Singer, D; Lackner, K S

Poster (2015)

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See detailThe earliest pioneer settlement in Eastern Finland : the Sarvinki-project and the Jokivarsi 1 site
Simponen, Laija; Pesonen, Petro; Hertell, Esa et al

Poster (2015)

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See detailEquine cadaver ligaments : A new promising source of stem cells
Shikh Al Sook, Mohamad Khir ULg; Gabriel, Annick ULg; Salouci, Moustafa et al

Poster (2015)

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See detailEvaluation du débit de filtration glomérulaire en population générale : résultats en Côte d’Ivoire E.
Yayo, E; Konan, JL; Aye, M et al

Poster (2015)

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See detailIn vitro degradation study of Polydioxanone (PDO) monofilaments
Sevrin, Chantal ULg; Lombart, François ULg; Kottgen, Cindy et al

Poster (2015)

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See detailCYTOTOXICITY EVALUATION OF A STARCH-BASED HYDROGEL LOADED WITH HYDROXYAPATITE AND CALCIUM CARBONATE FOR BONE REGENERATION
Flores Arriaga, J.C.; Cerda, Bernardino; Escobar, V. et al

Poster (2015)

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See detailThe SANGOMA Tools for Data Assimilation
Nerger, Lars; Altaf, Umer; Barth, Alexander ULg et al

Poster (2015)

The EU-funded project SANGOMA – Stochastic Assimilation of the Next Gener- ation Ocean Model Applications –provides new developments in data assimilation to ensure that future operational systems can make ... [more ▼]

The EU-funded project SANGOMA – Stochastic Assimilation of the Next Gener- ation Ocean Model Applications –provides new developments in data assimilation to ensure that future operational systems can make use of state-of-the-art data-assimilation methods and related analysis tools. One task of SANGOMA is to develop a collection of common tools for data assimilation with a uniform interface so that the tools are usable from dif- ferent data assimilation systems. The tool developments mainly aim at tools that support ensemble-based data assimilation applications like for the generation of perturbations, to perform transformations, to compute diagnostics, as well as further utilities. In addition, a selection of ensemble filter analysis steps is included. The tools are implemented in Fortran and as scripts for Matlab or Octave. They are provided as free open-source programs via the project web site [http://www.data-assimilation.net]. This contribution provides an overview of the tools that are available in the latest release V1 of the SANGOMA tools as well as the plans for the next release. [less ▲]

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See detailRevealing the structure and dynamics of magnetized O star winds through UV spectroscopy with HST
wade, G.; Walborn, N.R.; Fullerton, A.W. et al

Poster (2015)

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See detailAn unprecedented view of hot-star atmospheres from ASTRAL-II UV spectra: the early-types sample
Bianchi, L.; Ayres, T.; Hillier, D.J. et al

Poster (2015)

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See detailCharacterization of the Chitin-Glucan Complex extracted from Komagataella Pastoris cell wall
Farinha, I; Duarte, P.; Pimentel, A. et al

Poster (2015)

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See detailQuantitative Targeted Proteomics and Electrochromic Shift for Measuring Photosystem Content of Marine Phytoplankton
Malcolm, Christopher M.; Bailleul, Benjamin; Melanson, J.R. et al

Poster (2015)

Abundance and stoichiometry data for the photosystems, the intersystem electron transport complexes and the Calvin cycle enzymes are rich in information about light and nutrient acclimation. Quantifying ... [more ▼]

Abundance and stoichiometry data for the photosystems, the intersystem electron transport complexes and the Calvin cycle enzymes are rich in information about light and nutrient acclimation. Quantifying these complexes is essential for understanding limitations on and capacities for photosynthesis. Targeted quantitative immunodetections of conserved subunits (eg. PsbA for PSII; PsaC for PSI) are becoming an established method for absolute measurement of these complexes. An advantage of protein measurements is that they can be done with non-living flash-frozen samples and processed post-field. A pitfall of physical versus functional measures is that in some scenarios, such as during photoinhibition of photosystem II (PSII), physical and functional measures give different values, but such disparities are often meaningful, informing targeted studies of regulation, repair and enzyme kinetics. Electrochromic Shift (ECS) is an alternative, fast and noninvasive method which can be exploited to determine functional PSI:PSII ratios in living cells. The basis for ECS is that pigments in the photosynthetic membrane exhibit a shift in their absorption spectra when the electric component of the proton motive force is generated across the membrane in the light. Cross-validation of methods by independent measures builds confidence in results from both approaches and can be useful for ground truthing of underway or high-throughput optical measurements or functional measurements from bioassays. We present comparative data from immunoquantitation and ECS for an array of diatom taxa. The physical data fall within established ranges. The basis for similarities and disparities in the photosystem stoichiometries between the methods are discussed. [less ▲]

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See detailRole of Kinases in VZV Nuclear Egress
Blondeau, Caroline ULg; Istaz, Bastienne; Lebrun, Marielle ULg et al

Poster (2015)

Like all Herpesviruses VZV expresses two conserved proteins forming the nuclear egress complex (NEC), namely ORF24p and ORF27p, respectively homologous to UL34 and UL31 in HSV-1. Many works described the ... [more ▼]

Like all Herpesviruses VZV expresses two conserved proteins forming the nuclear egress complex (NEC), namely ORF24p and ORF27p, respectively homologous to UL34 and UL31 in HSV-1. Many works described the role of this complex and viral kinases, the Alpha-herpesvirus specific kinase US3p, and hCMV UL97p (conserved in all Herpesviruses and homolog to UL13p in HSV-1), in the nuclear capsids translocation to the cytoplasm. Indeed, using a very complex mechanism, not yet fully characterized, nuclear capsids bud through the internal nuclear membrane, stay briefly in the perinuclear space and finally free the capsids into the cytoplasm through fusion of the primary envelope with the external nuclear membrane. In the cytoplasm, virions acquire the second and last envelopment before being released outside the cells. In order to better characterize the nuclear egress in the context of VZV, we focused our work on the NEC and on both viral kinases ORF47p and ORF66p respectively homologous to HSV-1 UL13p and US3p. By co-immunoprecipitation we identified a protein complex containing ORF24p, ORF27p and both viral kinases and are currently trying to determine the role of each kinase in the formation of this complex. We are also characterizing the phosphorylation status of these proteins depending on ORF66p and/or ORF47p. Immunofluorescence studies of cells infected with a deleted ORF66 or ORF47 virus showed mislocalisation of some viral proteins such as ORF24p as described for HSV-1. Finally electron microscopy analyses are in progress and will help to determine the role of both VZV kinases in the nuclear egress. [less ▲]

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See detailShip collision on monopile offshore wind turbines
Bela, Andreea ULg; Le Sourne, Hervé; Buldgen, Loïc ULg et al

Poster (2015)

Every year, the offshore wind industry is expanding and the location of the future wind farms tends to move to deeper waters and closer to the traffic lanes. The consequence of this growth is that the ... [more ▼]

Every year, the offshore wind industry is expanding and the location of the future wind farms tends to move to deeper waters and closer to the traffic lanes. The consequence of this growth is that the probability of ship collisions will increase. For any new offshore wind farm projects, a collision risk analysis must be performed in order to identify the collision scenarios having the greatest probabilities of occurrence and to evaluate the consequences on the supporting structure and also on the mechanical parts of the wind turbines. The goal of this paper is to outline the behaviour of the monopile foundations during ship collision by performing non-linear finite elements simulations. Many collision scenarios are analysed in order to study the sensitivity of the monopile to a series of parameters like impact velocity of the striking ship, wind loads and soil stiffness. [less ▲]

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See detailAn empirical classification scheme for detection of impossible and improbable CRS-R subscore combinations
Chatelle, Camille ULg; Bodien, Yelena Guller; Carlowicz, Cecilia et al

Poster (2015)

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See detailA dynamic Unfolded Protein Response controls cortical neurogenesis
Creppe, Catherine ULg; Laguesse, sophie; Nedialkova, Dany et al

Poster (2015)

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See detailInsulin Sensitivity Profile as a Marker for Reduced Outcome in the Neonatal Intensive Care Unit
Uyttendaele, Vincent; Dickson, JL; Lynn, A et al

Poster (2015)

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See detailA retrospective study on Equine Herpes Virus type-1 associated myeloencephalopathy in France (2008-2011)
van Galen, G; Leblond, A; Tritz, P et al

Poster (2015)

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See detailA dynamic Unfolded Protein Response controls cortical neurogenesis
Creppe, Catherine ULg; Laguesse, Sophie; Nedialkova, Dany et al

Poster (2015)

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See detailVariation de la parathormone et de différents biomarqueurs osseux chez le patient hémodialysé
DELANAYE, Pierre ULg; Warling; Moonen, M et al

Poster (2015)

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See detailDetermination of absolute molecular weight of bioactive polycations
Plotnikova, Evgeniya ULg; Sevrin, Chantal ULg; Claes, Nicolas et al

Poster (2015)

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See detailGenetic study of triple negative breast cancers
Boukerroucha, M; Josse, Claire ULg; El Guendi, Sonia ULg et al

Poster (2015)

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See detailMachine Learning and Insulin Sensitivity in Determining Outcome in Preterm Infants
Uyttendaele, Vincent; Dickson, JL; Lynn, A et al

Poster (2015)

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See detailVolatile organic compounds emitted by Cavendish and Plantain banana plants
De Clerck, Caroline ULg; Kherkhofs, Celine; Berhal, Chadi et al

Poster (2015)

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See detailThe Influence of Context on Children’s Use of the Memorability Heuristic
Geurten, Marie ULg; Meulemans, Thierry ULg; Willems, Sylvie ULg

Poster (2015)

We examined children’s ability to employ a metacognitive heuristic based on memorability expectations to reduce false recognitions, and explored whether these expectations depend on the context in which ... [more ▼]

We examined children’s ability to employ a metacognitive heuristic based on memorability expectations to reduce false recognitions, and explored whether these expectations depend on the context in which the items are presented. Specifically, 4-, 6-, and 9-year-old children were presented with high-, medium-, and low-memorability words, either mixed together (Experiment 1) or separated into two different lists (Experiment 2). Results revealed that only children with a higher level of executive functioning (9-year-olds) used the memorability-based heuristic when all types of items were presented within the same list. However, all children, regardless of age or executive level, implemented the metacognitive rule when high- and low-memorability words were presented in two separate lists. Moreover, the results of Experiment 2 showed that participants processed medium-memorability words more conservatively when they were presented in a low- than in a high-memorability list, suggesting that children’s memorability expectations are sensitive to list-context effects. [less ▲]

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See detailContinuous Glucose Monitoring: Using CGM to Guide Insulin Therapy Virtual Trials Results
Mombaerts, L.; Thomas, Felicity Louise ULg; Signal, M.K et al

Poster (2015)

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See detailCanine idiopathic pulmonary fibrosis is not associated with herpes virus infection
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

Poster (2015)

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See detailMyoclonin 1 modulates the post-translational modification of microtubules
Medard, Laurie ULg; Lakaye, Bernard ULg; Godin, Juliette ULg et al

Poster (2015)

Juvenile myoclonic epilepsy is one of the most common forms of generalized genetic epilepsy. Genetic studies have shown that heterozygous mutations in Myoclonin1 are responsible for 3-9% of clinical cases ... [more ▼]

Juvenile myoclonic epilepsy is one of the most common forms of generalized genetic epilepsy. Genetic studies have shown that heterozygous mutations in Myoclonin1 are responsible for 3-9% of clinical cases worldwide. This protein contains three DM10 domains of unknown function and an EF-hand domain. We have previously demonstrated that Myoclonin1 is a microtubule-associated protein involved in cell division and radial migration during neocortex development. In cells, this protein co-localized with specific structures rich in microtubules (MTs) such as the centrosome, the poles of the mitotic spindle or the motile cilia but not with cytoplasmic MTs. This suggests post-translational modifications (PTM) of MTs may be important for the interaction between Myoclonin1 and MTs. We have co-express the different enzymes catalyzing PTM of MTs with Myoclonin1 in U2OS cell line. With one of these enzymes, we observed a strong increase in PTM in the presence of Myoclonin-1. This suggests that Myoclonin1 may interact with and modulate the activity of this enzyme. By using luciferase complementation assay and pull down experiments, we could demonstrate that it is indeed the case. Interestingly, the effect is observed even when a DM10 domain alone is co-expressed with the enzyme, suggesting for the first time a role for this domain. In conclusion our data suggest myoclonin-1 modulates specific PTM of MTs. This is of prime importance for microtubule dynamic and notably for neuroblast precursor migration during neocortex development. This could be the mechanism that explains why pathological forms of myoclonin-1 affect brain development. [less ▲]

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See detailQUANTIFYING CHEMICAL REACTIONS BY USING MIXING ANALYSIS IN GROUNDWATER-RIVER INTERFACE
Jurado Elices, Anna ULg; Vázquez-Suñé, Enric; Carrera, Jesus et al

Poster (2015)

This work is motivated by a sound understanding of the chemical processes that affect the organic pollutants in an urban aquifer. Urban aquifers may suffer pollution from different recharge sources such ... [more ▼]

This work is motivated by a sound understanding of the chemical processes that affect the organic pollutants in an urban aquifer. Urban aquifers may suffer pollution from different recharge sources such as leakage from sewer and septic systems, seepage from rivers, seawater intrusion, and losses from water supply network. As a result, a wide range of organic pollutants are found in urban aquifers (Fig. 1). Since these pollutants reach groundwater environment, their occurrence depends on simultaneous transport and biogeochemical processes. However, the quantification of these processes is not an easy task. The objective of this work is to propose an approach to quantify the chemical processes that occurs when river water infiltrates an aquifer. [less ▲]

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See detailPOLYMER BIODEGRADABLE MATRICES WITH ENHANCED SURFACE PROPERTIES FOR TISSUE ENGINEERING
Markvicheva, Elena; Drozdova, Maria; Demina, Tatiana et al

Poster (2015)

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See detailCOST Action FA1407: Empowering NGS technologies for the study and diagnostic of plant viruses
Olmos, Antonio; Boonham, Neil; Büttner, Carmen et al

Poster (2015)

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See detailMT4-MMP (MMP17) as a therapeutic target in metastatic solid tumors
Noël, Agnès ULg

Poster (2015)

Others and we have identified the glycosylphosphatidyl inositol (GPI) anchored MMP called MT4-MMP or MMP-17 as a main driver of cancer cell metastasis in breast (1-3), head and neck (4) and colon cancers ... [more ▼]

Others and we have identified the glycosylphosphatidyl inositol (GPI) anchored MMP called MT4-MMP or MMP-17 as a main driver of cancer cell metastasis in breast (1-3), head and neck (4) and colon cancers (5). More recently, we demonstrated a functional link between MT4-MMP and EGFR signaling in promoting breast cancer cell proliferation in vivo and in 3D culture models. We found that MT4-MMP is a key partner of EGFR activation and signaling (6), which is independent of its enzymatic activity. In triple negative breast cancer (TNBC) cells, MT4-MMP promotes primary tumor growth and lung metastases (1,2). Herein, we investigated the clinical relevance of our finding by immunohistochemical (IHC) study of MT4-MMP and EGFR expression in human samples of several breast cancer subtypes including lobular and ductal carcinoma in situ, invasive carcinoma, triple negative ductal carcinoma and normal tissue. IHC staining of normal breast tissues with MT4-MMP antibody show no signal, whereas breast carcinomas are positives for MT4-MMP. Of note, a strong staining for MT4-MMP was observed in the triple negative breast cancer (TNBC), the most aggressive breast cancer subtype. TNBC are known to express high level of EGFR and treatment options are limited due to the non-response of the TNBC patients to the EGFR targeted therapy. By investigating 86 TNBC tumors, we found a strong correlation between MT4-MMP and EGFR expression in a 68 % of TNBC tumors. In parallel to the human study, by exploring the mechanism of MT4-MMP trafficking and internalization, we found for the first time that MT4-MMP can be recycled at the cell surface. Mechanistically, MT4-MMP uses a unique endocytic pathway, which relies on CLIC/GEEC route. In addition to deeply investigating its internalization dynamics, we also explored the mode of its oligomerization and dimerization at the cell surface. Altogether, we are providing mechanistic insights on how MT4-MMP availability is regulated and revealing unique features of this MT-MMP among other MT-MMPs. These findings can be useful for designing therapeutics to block its presence at the cell surface, rather than merely blocking its enzymatic activity to block its pro-tumor effects. (1) Chabottaux et al., 2006, Cancer Res 66, 5165-5172; (2) Host et al., 2012, Int. J. Cancer 131(7):1537-48; (3) Rizki et al., 2008, Cancer Res 68, 1378-1387), (4) Huang et al., 2009, Neoplasia 11, 1371-1382) (5) Nimri et al., 2013, Mol Carcinog 52, 859-870 (6) Paye et al., 2014, Cancer Res. 74(23):6758-70 [less ▲]

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See detailHeart rate variability as a measure of comfort in the anaesthetised horse
Lacroix, Alice; Gougnard, Alexandra ULg; Cerri, Simona ULg et al

Poster (2015)

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See detailAssimilation of HF radar surface currents to optimize forcing in the northwestern Mediterranean Sea
Marmain, J.; Molcard, A.; Forget, P. et al

Poster (2015)

HF radar measurements are used to optimize surface wind forcing and baroclinic open boundary condition (OBC) forcing in order to constrain model coastal surface cur- rents. This method is applied to a ... [more ▼]

HF radar measurements are used to optimize surface wind forcing and baroclinic open boundary condition (OBC) forcing in order to constrain model coastal surface cur- rents. This method is applied to a northwestern Mediterranean (NWM) regional primitive equation model configuration. A new radar data set, provided by two radars deployed in the Toulon area (France), is used. To our knowledge, this is the first time that radar mea- surements of the NWM Sea are assimilated into a circulation model. Special attention has been paid to the improvement of the model coastal current in terms of speed and position. The data assimilation method uses an ensemble Kalman smoother to optimize forcing in order to improve the model trajectory. Twin experiments are initially performed to evaluate the method skills (not shown here). Real measurements are then fed into the circulation model and significant improvements to the modeled surface currents, when compared to observations, are obtained. [less ▲]

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See detailTotal connectivity: a marker of dynamical functional connectivity applied to consciousness
Liegeois, Raphaël ULg; Phillips, Christophe ULg; Bahri, Mohamed Ali ULg et al

Poster (2015)

In the last years functional connectivity (FC) has become one of the most popular tools to explore and characterize information contained in fMRI =me series. The classical hypothesis on FC consists of ... [more ▼]

In the last years functional connectivity (FC) has become one of the most popular tools to explore and characterize information contained in fMRI =me series. The classical hypothesis on FC consists of considering it as constant (or static) over the whole fMRI time series. However, it has been emphasized recently that FC should be treated as a dynamical quantity, for example by using sliding windows of the fMRI time courses in order to compute a dynamical FC. We propose a comprehensive marker of FC based on an auto-regressive (AR) model of fMRI time series capturing its static and dynamic properties. We call it total connectivity and we illustrate the benefits of our approach on data of patients undergoing four different states of consciousness. [less ▲]

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See detailBridging familiarity-based recognition memory and novelty detection: A matter of timing
Delhaye, Emma ULg; Bastin, Christine ULg; Moulin, Christopher et al

Poster (2015)

Detailed reference viewed: 51 (6 ULg)
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See detailGenotyping analysis of placental site trophoblastic tumor (PSTT) complicating a twin pregnancy with a complete mole and coexistent viable fetus
Patrier, Sophie; Steenhaut, Patricia; Lamy, Aude et al

Poster (2015)

Detailed reference viewed: 8 (0 ULg)