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See detailDesign and synthesis of PET-probes targeting AMPA-subtype receptors
Deverdenne, François ULg; Claes, Giselle ULg; Goffin, Eric ULg et al

Poster (2015, June 05)

The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the ... [more ▼]

The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the maintenance of the long-term potentiation, a phenomenon closely linked to cognitive and memorization processes. Based on experimental data collected in recent years, the use of AMPA potentiators seems to be an interesting approach in the treatment of cognitive deficits (e.g. Alzheimer disease), schizophrenia or depression. Such AMPA signal potentiation could be mediated by positive allosteric modulators (PAMs) of the AMPA receptors, a class of compounds able to produce a fine signal tuning in the presence of the endogenous ligand in the synapse, providing less toxicity than direct agonists. With this approach, the laboratory of Medicinal Chemistry of Liège university developed many series of AMPA potentiators , among which 1,2,4-benzothiadiazine 1,1-dioxides (BTDs). In order to better understand the in vivo mapping of AMPA receptors and its evolution in neurological diseases, the present work aims at developing the design and the synthesis of BTDs positive allosteric modulators radiolabeled with a fluorine-18 atom. Based on previously synthesized series in this field, we investigate the synthesis of a new class of high-affinity AMPA potentiators characterized by the presence of a fluorine atom at selected positions on the structure of the AMPA potentiators. Thanks to in vitro pharmacological evaluations, we will further determine the best candidates for their fluorine-18 radiolabeling. [less ▲]

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See detailCXCR7/ACKR3 is activated by chemokines from both CXC and CC subfamilies
Szpakowska, Martyna ULg; Counson, Manuel; Beaupain, Nadia et al

Poster (2015, June 05)

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See detailSpatio-temporal dynamics of β-tubulin isotypes and acetyl-alpha tubulin during the development of the sensory auditory organ in rodents.
Renauld, Justine ULg; Thelen, Nicolas ULg; Johnen, Nicolas ULg et al

Poster (2015, June 05)

The auditory organ is a highly specialized structure composed by specific cellular types. The sensory cells are characterized by stereocilia at their apex and are necessary for the sound perception. These ... [more ▼]

The auditory organ is a highly specialized structure composed by specific cellular types. The sensory cells are characterized by stereocilia at their apex and are necessary for the sound perception. These cells are supported by supporting cells. Supporting cells possess a characteristic cytoskeleton in direct relation with their morphological features and their development. There are different β-tubulin isoforms in microtubules of vertebrate tissues. However, their functional significance is still largely unknown. In the present study, we investigated the localization of five β-tubulin isotypes (β 1 to 5) as well as acetyl-α-tubulin within the hearing organ during development in rodents. By using confocal microscopy, we showed that with the exception of the β3-tubulin isoform that was specific to nerve fibres, all the different β-tubulin isoforms and acetyl-α-tubulin were mainly present in the supporting cells. Contrary to β1-4-tubulins, we also found that the β5-tubulin isoform appeared only at a key stage of the postnatal development in specific cell types (pillar cells and Deiters’ cells). By using transmission electron microscopy, we revealed further that this developmental stage coincided with the formation of two separate bundles of microtubules from a unique one in these supporting cells. In conclusion, these results suggest that the β5-tubulin isoform might be involved in the generation of new microtubule bundles from a pre-existing one. [less ▲]

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See detailCritical periods and critical values explaining fluxes inter-annual variability in a temperate mixed forest
Hurdebise, Quentin ULg; Vincke, Caroline; De Ligne, Anne ULg et al

Poster (2015, June 04)

In order to explain inter-annual variability of Net Ecosystem CO2 Exchange (NEE) above a mixed temperate forest, two approaches were followed: •Detection of critical periods using the R-squared of the ... [more ▼]

In order to explain inter-annual variability of Net Ecosystem CO2 Exchange (NEE) above a mixed temperate forest, two approaches were followed: •Detection of critical periods using the R-squared of the regression between annual NEE and cumulated NEE on a mobile window. •Identification of critical values of a threshold used to decompose annual and seasonal NEE in two components. [less ▲]

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See detailSimulations of the auroral signatures of Jupiter’s magnetospheric injections
Dumont, Maïté ULg; Grodent, Denis ULg; Radioti, Aikaterini ULg et al

Poster (2015, June 04)

Jupiter’s ultraviolet auroral emissions are divided into four main components: the polar emissions, the main emission, the satellite footprints and the outer emissions. The morphology of the outer ... [more ▼]

Jupiter’s ultraviolet auroral emissions are divided into four main components: the polar emissions, the main emission, the satellite footprints and the outer emissions. The morphology of the outer emissions can be either diffuse, arc-shaped or compact emissions. In the present study, we focus on outer emissions clearly detaching from the main emission and forming compact structures that are evolving regardless of the rest of the auroral emission. These auroral features were selected because they have the same appearance as the auroral signature of a clearly identified injection previously observed by Mauk et al. [2002] at Jupiter, based on simultaneous Galileo spacecraft and Hubble Space Telescope measurements. Here, we report on the evolution of those ultraviolet auroral features appearing in Hubble Space Telescope images of the northern and southern Jovian hemispheres. We investigate the possibility that those ultraviolet auroral structures are associated with energetic particle injections. For this study, we analyze the temporal variations of the longitudinal extent and of the brightness of the auroral structures. Indeed, the injected charged particles drift at different rates due to energy-dependent gradient and curvature drifts, which leads to an increase with time of the longitudinal extent of the feature and of its associated auroral signature. Since the injected energy follows the same trend, the brightness decreases with time. Different processes can generate auroral signatures of plasma injections. We simulate them by considering that pitch angle diffusion is generated by the precipitating energy flux in the ionosphere and whistler-mode waves through electron scattering. We compare the characteristics of the simulated signature with the observed parameters. Following this comparison, we are able to test whether the aforementioned mechanism is responsible for the auroral emission and to infer the typical energy and the spectral index of the energy distribution of the electrons involved in the injection process. [less ▲]

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See detailThe Main Auroral Emission at Jupiter: Altitude profile and Dawn-Dusk Asymmetry
Bonfond, Bertrand ULg; Gustin, Jacques ULg; Gérard, Jean-Claude ULg et al

Poster (2015, June 04)

The main auroral emission at Jupiter generally forms a quasi-continuous curtain around each magnetic poles. This emission magnetically maps to the middle magnetosphere and is related to the corotation ... [more ▼]

The main auroral emission at Jupiter generally forms a quasi-continuous curtain around each magnetic poles. This emission magnetically maps to the middle magnetosphere and is related to the corotation enforcement of the plasma originating from the volcanic satellite Io. The first models of corotation enforcement current system at Jupiter assumed symmetry around the magnetic axis. However, observations and further development of these models outlined the importance of local time variability of such currents. In this presentation, we show the results of two studies of this local time variability relying on the large dataset of Far-UV observations from the Hubble Space Telescope (HST). Knight’s theory of field aligned current predicts that the auroral precipitating energy flux and the energy of the precipitating electrons are correlated. Since the altitude of the auroral emissions decreases as the energy increases, it is thus expected that the altitude of the auroral brightness peak varies as a function of the local time following the variations of the field aligned currents. We compare the altitude of the main emission on the post-dusk side as seen in the visible domain by Galileo’s Solid State Imager and the same altitude for the night side as seen by the Advanced Camera for Surveys (ACS) on board HST in the Far-UV domain. We show some significant differences between the two data sets. Unfortunately, a careful analysis involving both spectral observations and simulations indicates that the Far-UV vertical profiles are hampered by observational ambiguities due to absorption by hydrocarbon molecules. Only additional and judiciously designed new observations could reveal the actual amount of methane along the line of sight. The second study consists in a comparison of the emitted power in local time sectors corresponding to dawn and dusk. Results in the northern hemisphere are difficult to interpret because the magnetic anomaly probably causes a decrease of the auroral brightness in regions of strong magnetic field. In the southern hemisphere, where the field magnitude is more uniform along the main oval, the dusk sector is ~3 times brighter than the dawn sector. In accordance with measurements of magnetic field divergence in the equatorial plane by Galileo, these results suggest the presence of a partial ring current in the night side of the magnetosphere with upward currents in the dawn side and downward currents in the dusk side. [less ▲]

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See detailImpact of biomaterial physical characteristics on bone regeneration: Comparison of three hydroxyapatites
LAMBERT, France ULg; Bacevic, Miljana ULg; Schupbach, P et al

Poster (2015, June 03)

Bone regeneration biomaterials with identical chemical compositions are frequently considered by clinicians as similar. However, the clinical performance of regenerative biomaterial may be influenced by ... [more ▼]

Bone regeneration biomaterials with identical chemical compositions are frequently considered by clinicians as similar. However, the clinical performance of regenerative biomaterial may be influenced by other parameters such as topographical properties. [less ▲]

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See detailPolyplex Based on Polycarbonate Polymers for an Efficient Delivery of HDAC5 and HDAC7 siRNA
Frère, Antoine ULg; Tempelaar, Sarah; Peulen, Olivier ULg et al

Poster (2015, June 02)

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See detailBIOREFINE Project – Recovery of useful nutrients from organic wastes produced in five European countries (3AV.3.55)
Tarayre, Cédric ULg; De Clercq, Lies; Michels, Evi et al

Poster (2015, June 01)

At this time, many wastes are used or eliminated through processes that do not really consider their potential applications. Such wastes contain useful nutrients (nitrogen, phosphorus and potassium), the ... [more ▼]

At this time, many wastes are used or eliminated through processes that do not really consider their potential applications. Such wastes contain useful nutrients (nitrogen, phosphorus and potassium), the importance of which has been demonstrated in agriculture for many years. The composition of wastes is highly heterogeneous, which makes treatment techniques more difficult to apply on a large scale. Sewage sludge is usually used as a fertilizer in agriculture, in energy production or in the field of construction. The main use of manure is agriculture, although considerable amounts of nutrients are lost and cause pollution. Digestate is also used in agriculture, but other alternatives have been proposed. Ashes should also be highlighted, although they do not contain nitrogen, which is lost into the atmosphere during the combustion process. Finally, household and industrial wastes are resources that should be considered as well. Those different types of wastes could be recycled to produce environment-friendly fertilizers. Here, we propose to investigate these opportunities inside five European countries (Belgium, France, Germany, United Kingdom and The Netherlands) through five work packages with the BioRefine Project. [less ▲]

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See detailEx Parrot: The Aarhus-Sydney gamma Dor experiment on pulsations and rotation
Antoci, V.; Ouazzani, R.; Murphy, S. et al

Poster (2015, June 01)

γ Doradus stars, exhibiting pure gravity modes pulsations, occupy the region between the solar-like oscillators and the delta Sct stars in the HRD. The Kepler mission delivered data of unprecedented ... [more ▼]

γ Doradus stars, exhibiting pure gravity modes pulsations, occupy the region between the solar-like oscillators and the delta Sct stars in the HRD. The Kepler mission delivered data of unprecedented quality spanning up to 4 years, allowing to resolve closely spaced modes to measure, e.g., period spacings and to infer internal rotation profiles. Here we present an ensemble study of all γ Doradus stars observed with the Kepler mission. We investigate among others the range of excited modes, their amplitudes and the impact of rotation on these quantities. Our aim is to better understand the pulsation excitation as well as the mode selection mechanism in these stars. Our results may help to also explain the lack of solar-like oscillators exhibiting g-modes pulsations on the main sequence, although the instability domains of γ Doradus and solar-like stars overlap. [less ▲]

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See detailWhat can we learn from asteroseismology of beta Cephei stars?
Salmon, Sébastien ULg; Montalban, J.; Miglio, A. et al

Poster (2015, June 01)

Detailed reference viewed: 7 (0 ULg)
See detailHubble Space Telescope observations of variation of the O I 135.6 nm/ O I 130.4 nm ratio in Ganymede’s atmosphere
Molyneux, P. M.; Nichols, J. D.; Bannister, N. P. et al

Poster (2015, June)

We present new high-sensitivity HST/COS measurements of the atmospheric O I 135.6 nm/ O I 130.4 nm ratio at Ganymede, which we show exhibits significant spatial and temporal variability. Specifically, the ... [more ▼]

We present new high-sensitivity HST/COS measurements of the atmospheric O I 135.6 nm/ O I 130.4 nm ratio at Ganymede, which we show exhibits significant spatial and temporal variability. Specifically, the ratios observed on Ganymede’s leading hemispheres vary between 2.14±0.03 and 2.67±0.02, while on the trailing hemisphere the ratios are observed to be between 0.98±0.02 and 1.53±0.03. These high-sensitivity observations increase the signal to noise of these measurements by an order of magnitude over previous HST/STIS observations of the same [1], thus confirming that the temporal variation suggested by these previous observations is real. The emissions are excited through electron-impact excitation of Ganymede’s oxygen atmosphere by electrons which are locally accelerated within its magnetosphere [2,3]. The variation in the ratio magnitude may be explained either by variations in the ratio of atomic to molecular oxygen in the atmosphere or by a change in the temperature of the electrons exciting the emissions. An increase in the proportion of molecular oxygen acts to increase the ratio, as does a cooler electron temperature.References [1] Feldman, P. D., McGrath, M. A., Strobel, D. F., Moos, H. W., Retherford, K. D. and Wolven, B. C., HST/STIS ultraviolet imaging of polar aurora on Ganymede, Astrophys. J., Vol. 535, pp. 1085-1090, 2000. [2] Hall, D. T., Feldman, P. D., McGrath, M. A. and Strobel, D. F., The far-ultraviolet oxygen airglow of Europa and Ganymede, Astrophys. J., Vol. 499, pp. 475-481, 1998. [3] Eviatar, A., Strobel, D. F., Wolven, B. C., Feldman, P. D., McGrath, M. A. and Williams, D. J., Excitation of the Ganymede ultraviolet aurora, Astrophys. J., Vol. 555, pp. 1013-1019, 2001. [less ▲]

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See detailThe mysteries of droplet birth in microfluidic cross junctions
Van Loo, Stéphanie ULg

Poster (2015, June)

In microfluidics flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. Nevertheless, the scaling laws associated to droplet length, speed and frequency could ... [more ▼]

In microfluidics flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. Nevertheless, the scaling laws associated to droplet length, speed and frequency could not be identified yet, owing to the large number of parameters involved (incl. complex geometry). We here present an experimental study of droplet formation in a microfluidic cross-junction with a minimum number of geometrical parameters. We mostly focus on the dripping regime. The formation sequence is decomposed in two steps, inflation and squeezing, that vary differently according to both water and oil flow rates. These variations reveal several insights about the fluid flows in both phases. From there we infer the scaling law that relates droplet volume and frequency to the Capillary number associated to each inlet flow rate. This law involves a minimum of fitting parameters. We finally discuss the influence of inlet control (flow rate vs. pressure) and surfactants on the formation dynamics. [less ▲]

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See detailThe class IIa HDACs prevent degradation of RBFOX2 by Chaperone-Mediated Autophagy
Detiffe, Cécile ULg; Dequiedt, Franck ULg; Rambout, Xavier ULg

Poster (2015, June)

By modulating the acetylation level of histones, histone deacetylases (HDACs) are enzymes playing a key role in the control of gene expression. In addition to histones, HDACs also have non-histone ... [more ▼]

By modulating the acetylation level of histones, histone deacetylases (HDACs) are enzymes playing a key role in the control of gene expression. In addition to histones, HDACs also have non-histone substrates, which may relate to potential roles for HDACs outside of gene regulation. Because HDACs are key regulators of major cellular processes such as cell division, apoptosis and differentiation, it is not surprising that these enzymes have emerged as attractive therapeutic targets for cancer. While the in vivo antitumoral activities of several small molecules HDACs inhibitors have generated a lot of hope, these molecules often showed dramatic side-effects. It is suspected that these side effects could be related to unknown functions of HDACs. The goal of this project is to identify novel, unsuspected functions of HDACs that will help developing more efficient and specific HDAC-based antitumoral therapies. To identify novel functions of HDACs, we used a high-throughput yeast two hybrid (Y2H) approach. This led to the first comprehensive interactomic map of class IIa HDACs that includes 84 protein partners. Among new HDACs partners, we identified several RNA-binding proteins (RBPs) involved in mRNA processing. In this work, we focused on one, the alternative splicing regulator RBFOX2, and investigated its regulation by class IIa HDACs. Through various approaches, we verified that HDAC7 interacts with RBFOX2. In addition, we found that silencing of HDAC7 correlates with a decrease in stability of RBFOX2. Because we identified a potential CMA-specific KFERQ motif in RBFOX2, we tested the possibility that RBFOX2 might be degraded through Chaperone-Mediated Autophagy (CMA). Supporting this hypothesis, we found that RBFOX2 interacts with the co-chaperone HSC70. RBFOX2 levels are sensitive to CMA inducers, including serum starvation and 6AN. Interestingly, we found that a lysine residue in the KFERQ motif of RBFOX2 is acetylated, suggesting that HDAC7 might control RBFOX2 degradation through reversible acetylation. Indeed, degradation of RBFOX2 following HDAC7 silencing was reverted with an inhibitor of autophagy, bafilomycin A1. Analysis of RNA splicing pattern in cells depleted for HDAC7 showed that absence of HDAC7 is associated with 159 alternative splicing events. These events mostly include exon skipping that is known to be the major splicing event in which RBFOX2 is involved. In addition, we observed a highly statistically overlap between splicing events associated with RBFOX2 and HDAC7 depletion. [less ▲]

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See detailSingle molecule force spectroscopy on oligorotaxane foldamers
Sluysmans, Damien ULg; Hubert, Sandrine ULg; Bruns, Carson et al

Poster (2015, June)

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See detailDevelopment of a field test to evaluate colostrum quality (IgG) in cattle
Guyot, Hugues ULg; Dubreucq, Pierre ULg; Lebreton, Pascal et al

Poster (2015, June)

Failure of transfer of immunity from dam’s colostrum generates a negative effect on calves’ health leading to increased morbidity and mortality (De Nise et al., 1989; Wittum and Perino, 1995 ... [more ▼]

Failure of transfer of immunity from dam’s colostrum generates a negative effect on calves’ health leading to increased morbidity and mortality (De Nise et al., 1989; Wittum and Perino, 1995). Immunoglobulins (IgG) content of colostrum is highly variable and cannot be predicted. Distinguishing good from poor quality colostrum allows to adapt the volume administered or to initiate ancillary procedures for a sufficient transfer of IgG. The aim of the study was to evaluate the performances of a field test for colostrum quality determination. [less ▲]

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See detailDevelopment of a field test to evaluate colostral immunity transfer in young calves
Guyot, Hugues ULg; Dubreucq, Pierre ULg; Lebreton, Pascal et al

Poster (2015, June)

Failure of transfer of immunity from dam’s colostrum generates a negative effect on calves’ health leading to increased morbidity and mortality (De Nise et al., 1989; Wittum and Perino, 1995). Unawareness ... [more ▼]

Failure of transfer of immunity from dam’s colostrum generates a negative effect on calves’ health leading to increased morbidity and mortality (De Nise et al., 1989; Wittum and Perino, 1995). Unawareness of the colostral quality and variation in the calf’s capability to efficiently absorb immunoglobulins (IgG) supports the need for specific evaluation of the immunity transfer at a herd level. The aim of the study was to evaluate the performances of a field test for passive immunity transfer (PIT) in calves. [less ▲]

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See detailWhat are the determinants of the operational losses severity distribution ? A multivariate analysis based on a semiparametric approach.
Hambuckers, julien ULg; Heuchenne, Cédric ULg; Lopez, Olivier

Poster (2015, June)

In this paper, we analyse a database of around 41,000 operational losses from the European bank UniCredit. We investigate three kinds of covariates: firm-specific, fi- nancial and macroeconomic covariates ... [more ▼]

In this paper, we analyse a database of around 41,000 operational losses from the European bank UniCredit. We investigate three kinds of covariates: firm-specific, fi- nancial and macroeconomic covariates and we study their relationship with the shape parameter of the severity distribution. To do so, we introduce a semiparametric approach to estimate the shape parameter of the severity distribution, conditionally to large sets of covariates. Relying on a single index assumption to perform a dimension reduction, this approach avoids the curse of dimensionality of pure multivariate nonparametric techniques as well as too restrictive parametric assumptions. We show that taking into account variables measuring the economic well being of the bank could cause the required Operational Value-at-Risk to vary drastically. Especially, high pre-tax ROE, efficiency ratio and stock price are associated with a low shape parameter of the severity distribution, whereas a high market volatility, leverage ratio and unemployment rate are associated with higher tail risks. Finally, we discuss the fact that the considered approach could be an interesting tool to improve the estimation of the parameters in a Loss Distribution Approach and to offer an interesting methodology to study capital requirements variations throughout scenario analyses. [less ▲]

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See detailStudy of N-linked glycosylation in different life stages of the red flour beetle (Tribolium castaneum)
Smargiasso, Nicolas ULg; Walski, Tomasz; Van Damme, Els et al

Poster (2015, June)

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See detailSearch for Satellite Effects on Saturn's Auroras in Cassini UVIS Data
Pryor, Wayne; Espositio, Larry; Jouchoux, Alain et al

Poster (2015, June)

The Cassini Ultraviolet Imaging Spectrograph (UVIS) has been obtaining Saturn auroral images since 2004. We have previously reported instances when the main auroral oval brightened briefly in a quasi ... [more ▼]

The Cassini Ultraviolet Imaging Spectrograph (UVIS) has been obtaining Saturn auroral images since 2004. We have previously reported instances when the main auroral oval brightened briefly in a quasi-periodic fashion near the sub-Mimas longitude. Here we examine the large set of UVIS auroral images obtained from close range and high sub-spacecraft latitudes. We will plot the brightness of the individual auroral measurements (and binned auroral measurements) as a function of local time, and as a function of the location of Mimas and other moons to test for any correlations. Mimas, while a relatively small moon, exerts a strong influence on Saturn's ring system. Mimas creates the Cassini Division between the A and B rings and forces a non-circular shape to the outer edge of Saturn's B ring that is partially locked to Mimas phase. [less ▲]

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See detailOptimisation de milieux de culture pour Bifidobacterium bifidum et Bifidobacterium crudilactis et étude de l’effet antimicrobien des surnageants de culture
Bondue, Pauline ULg; Delcenserie, Véronique ULg; Crevecoeur, Sébastien ULg et al

Poster (2015, June)

Modulé entre autre par notre alimentation, le microbiote intestinal influence notre santé. Un enfant allaité sera en meilleure santé qu’un enfant nourri avec des formulations commerciales. Ceci est ... [more ▼]

Modulé entre autre par notre alimentation, le microbiote intestinal influence notre santé. Un enfant allaité sera en meilleure santé qu’un enfant nourri avec des formulations commerciales. Ceci est notamment dû à la présence d’oligosaccharides complexes dans le lait maternel (HMO). Les oligosaccharides ajoutés au lait maternisé sont d’origine végétale et leur structure est très éloignée de celle des HMO. Parce que les HMO ressemblent aux glycans de la paroi épithéliale, les pathogènes intestinaux infantiles s’y fixent et sont expulsés naturellement. Le lait de vache possède des oligosaccharides complexes (BMO), dont la structure est très similaire à celle des HMO. Les bifidobactéries rencontrées majoritairement dans les matières fécales d’un nourrisson devraient pouvoir métaboliser les BMO, tout comme celles isolées dans le lait de vache. Les objectifs de cette étude étaient d’étudier le potentiel de croissance de bifidobactéries d’origine bovine ou humaine sur des milieux de culture enrichis en lactosérum et BMO. Le deuxième objectif était de vérifier si le catabolisme de ces sucres complexes induisaient une synthèse de métabolites influençant l’expression de virulence de certains pathogènes tels qu’Escherichia coli O157 :H7. Une souche de Bifidobacterium bifidum, isolée à partir des matières fécales d’un nourrisson exclusivement allaité et une souche de Bifidobacterium crudilactis, isolée à partir de fromage au lait cru, ont été mises en culture dans des milieux contenant différentes sources d’hydrates de carbone (glucose, lactosérum naturellement riche en lactose et BMO, et 3’-syalillactose (3’SL)). Le 3’SL est un oligosaccharide complexe majoritaire parmi les BMO. Les surnageants des différents milieux de culture ont été prélevés et concentrés par lyophilisation puis mis en contact avec E. coli O157 :H7. L’expression relative de différents gènes de virulence d’E. coli O157:H7, fliC, ler, stx2b et luxS a été étudiée. Dans le futur, les BMO et certaines souches d’origine bovine ou humaine pourraient s’avérer être des compléments alimentaires intéressants pour maintenir ou rétablir la santé intestinale des jeunes enfants. [less ▲]

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See detailExtracellular peptidase hunting for improvement of protein production in plant cells and roots
Lallemand, Jérôme ULg; Bouché, Frédéric ULg; Desiron, Carole et al

Poster (2015, June)

Plant-based biopharmaceuticals have gained a lot of interest in the past decade due to their reduced cost and relative safety compared to mammalian cell cultures. While the first plant-made recombinant ... [more ▼]

Plant-based biopharmaceuticals have gained a lot of interest in the past decade due to their reduced cost and relative safety compared to mammalian cell cultures. While the first plant-made recombinant proteins are now reaching the market, the production systems still need improvements to maximize their competitiveness, proteolysis being one of the main factors limiting the yields. Identifying and inhibiting in vivo endogenous proteases involved in the degradation of recombinant proteins could then lead to a significant increase in production yields. In this study, we focused on two different production systems in Arabidopsis thaliana: rhizosecretion and cell suspensions. Extracellular proteases of both systems were used in vitro to study the conditions of target protein degradation (Bovine Serum Albumine, BSA). First, proteases from both systems degrade BSA at both acidic and neutral-to-basic pH conditions. Then, serine and metallopeptidases were shown to be the main protease classes responsible for BSA degradation by rhizosecreted proteomes or extracellular cell culture media, respectively. Finally, the biochemical tests were coupled to a bioinformatics analysis of publicly available transcriptomic data, in order to reduce the number of the proteases most likely involved in BSA degradation. Using this method, only five serine proteases and two metallopeptidases remain candidates for an amiRNA-mediated in vivo inhibition. [less ▲]

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See detailDeciphering the metabolism of polyprenyl-phosphate: The universal glycan lipid carrier at the membrane frontier
Manat, Guillaume; Roure, Sophie; El Ghachi, Meriem ULg et al

Poster (2015, June)

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See detailControlled synthesis of multi-functional polymers bearing pendant catechols for surface modifications
Patil, Nagaraj ULg; Aqil, Abdelhafid ULg; Jérôme, Christine ULg et al

Poster (2015, June)

Poly(ethylene glycol) (PEG)-based polymers have been widely employed in anti-fouling coating applications due to their robust bio-relevant properties including water solubility and biocompatibility ... [more ▼]

Poly(ethylene glycol) (PEG)-based polymers have been widely employed in anti-fouling coating applications due to their robust bio-relevant properties including water solubility and biocompatibility. However, limited by its poor adhesion towards surfaces, demands an addition modification strategies. Mussel adhesive proteins (MAPs) are potential models for adhesive polymers, which exhibits underwater adhesion towards dissimilar materials under environmentally challenging conditions. Most often experimentally simple, but structurally complex poly(dopamine) has been used as an analogues of MAPs for metal chelation, cross-linking and surface binding purposes. Inspired by MAPs, we have developed catechol-bearing copolymers for surface adhesion of stainless steel. This study describes the synthesis and reversible addition−fragmentation chain transfer (RAFT) polymerization of mussel-inspired acetonide-protected dopamine (meth)acrylamide monomers (ADA and ADMA). A series of well-defined P(PEGAm-b-ADAn) and P(ADMAn-b-PEGMAm) copolymers across a range of molar masses (13−42 kg/mol) with low molar mass dispersities (Đ = 1.12−1.25) were reported for the first time. Post polymerization TFA treatment yields block copolymers bearing free –catechol units in quantitative yields (>95%). The self-assembling nature of amphiphilic block-copolymers was studied by 1H-NMR, DLS and TEM. Surface functionalization and anti-fouling experiments were performed in real time using quartz crystal microbalance coupled with dissipation (QCM-D). The copolymer upon oxidation yields reactive quinones, which can be exploited to cross-link with chitosan (also, polymers with free –NH2 and –SH groups), thereby producing nano(macro)gels. In general, these novel class of block copolymeric ligand systems can be foreseen as versatile ingredients in material chemistry to obtain biocompatible multifunctional systems, benefited by high water solubility with inherent stealth ability and protein-repellency, as well as effective chelating groups, and may find application for a variety of biomedical fields, of which we have illustrated an important example. [less ▲]

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See detailThe neuroimaging meta-analysis database: A data-sharing initiative for neuroimaging meta-analyses
Reid, Andrew; Bzdok, Danilo; Genon, Sarah ULg et al

Poster (2015, June)

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See detailComparison of PLS and SVM discriminant analysis for NIR hyperspectral data of wheat roots in soil
Eylenbosch, Damien ULg; Fernández Pierna, Juan Antonio; Baeten, Vincent et al

Poster (2015, June)

The aim of this work was to compare the chemometric tools PLS and SVM on near infrared spectra in order to reach the most accurate discrimination between spectra of soil, root and crop residues of winter ... [more ▼]

The aim of this work was to compare the chemometric tools PLS and SVM on near infrared spectra in order to reach the most accurate discrimination between spectra of soil, root and crop residues of winter wheat on hyperspectral images. [less ▲]

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See detailGenetic depletion of the dual specificity protein phosphatase DUSP3 promotes LLC Lung tumour metastasis
Vandereyken, Maud ULg; Amand, Mathieu; Van Overmeire, Eva et al

Poster (2015, June)

DUSP3, also called Vaccinia-H1 Related (VHR) is a small dual specificity phosphatase dephosphorylating both tyrosine and serine/threonine phosphorylated residues. DUSP3 plays an important role in cell ... [more ▼]

DUSP3, also called Vaccinia-H1 Related (VHR) is a small dual specificity phosphatase dephosphorylating both tyrosine and serine/threonine phosphorylated residues. DUSP3 plays an important role in cell cycle regulation and is up-regulated in several human cancers. The physiological role of this phosphatase is, however, poorly understood. We have recently generated a DUSP3 knockout mouse by homologous recombination. The obtained mice have no spontaneous phenotype or pathology. However, DUSP3 deficiency prevented neo-vascularization of subcutaneously transplanted Matrigel plugs and Lung Lewis Carcinoma (LLC) tumours, suggesting an involvement of DUSP3 in tumour angiogenesis. Considering the importance of angiogenesis in metastatic formation, our study aimed to investigate the role of DUSP3 in metastatic dissemination. To do so, we used the LLC experimental metastasis model that shortcuts the intravasation/extravasation processes by injecting intravenously the LLC and the B16 (metastatic melanoma cell line) cells. Surprisingly, LLC, but not B16, lung metastasis developed twice faster in DUSP3-KO than WT mice. The enhanced LLC metastatic growth in DUSP3-/- mice was transferable to WT mice via DUSP3-/- bone marrow adoptive transfer, suggesting an involvement of the hematopoietic compartment in the observed phenotype. This was confirmed by a higher infiltration of neutrophils and macrophages in the lungs of DUSP3-KO compared to WT mice after LLC injection. This infiltration was correlated with higher expression of the chemokine receptor CCR2 in LLC-bearing DUSP3-KO lungs macrophages. Interestingly, LLC, but not B16 cells, were found to secrete high level of CCL2/MCP1, the CCR ligand chemokine. In line with this observation, we found that DUSP3-/- bone marrow derived-macrophages have a higher migration potential in response to LLC, but not B16, -conditionned medium. Altogether, our results suggest that DUSP3 plays an important role in metastatic dissemination/growth by a mechanism involving the control of CCR2-CCL2 chemoattraction axis in macrophages. [less ▲]

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See detailRemoval of antibiotic resistant bacteria in wastewater treatment plant
Bardiau, Marjorie ULg; Trajano, D; Taylor, H et al

Poster (2015, June)

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See detailCharacteristics of Jupiter's auroral acceleration region
Ray, Licia; Gustin, Jacques ULg; Grodent, Denis ULg

Poster (2015, June)

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. The magnetospheric drivers of the emission are relatively well understood, yet the high-latitude characteristics of ... [more ▼]

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. The magnetospheric drivers of the emission are relatively well understood, yet the high-latitude characteristics of the interaction have not been measure in-situ. Ahead of Juno’s arrival next summer, we use HST STIS observations of Jupiter’s auroral emission to infer the location of Jupiter’s auroral acceleration region and the properties of the precipitating auroral electrons. We analyze two images of Jupiter’s northern emission, determining the precipitating electron energy and incident energy flux for the main aurora, Io spot, Ganymede footprint, and flare regions. The resulting relationships between energy flux and electron precipitation energy for the main auroral emission are compared to the theoretical relationship derived by Lundin & Sandahl [1978] for a range of auroral region locations, and temperatures and densities appropriate for the jovian system. [less ▲]

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See detailControlled clinical trial of repeated left prefrontal transcranial direct current stimulation in patients with chronic minimally conscious state
Martial, Charlotte ULg; Thibaut, Aurore ULg; Wannez, Sarah ULg et al

Poster (2015, June)

A recent study showed that single-session anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (LDLPF) transiently improves consciousness in 43% of ... [more ▼]

A recent study showed that single-session anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (LDLPF) transiently improves consciousness in 43% of patients in minimally conscious state (MCS) (Thibaut et al., 2014). We here test the potential effects and safety of repeated tDCS in severely brain-damaged patients with MCS. In this double-blind cross-over sham-controlled experimental design, we delivered two sessions of repeated (5 days of stimulation) tDCS, either anodal or sham in a randomized order. We stimulated the LDLPF cortex during twenty minutes in 20 MCS patients (12 men, aged 48±16 years, time since onset 78±95 months, 12 post-traumatic). Consciousness was assessed by the French adaptation of the Coma Recovery Scale Revised (CRS-R; Schnakers et al., 2008) before and after each stimulation. A treatment effect was observed for the comparison between CRS-R total scores at baseline and after 5 days of real tDCS (p<0.01). Behaviorally, 10/20 patients showed a tDCS-related improvement; 5 patients responded after the first stimulation and 5 other patients responded after 2, 3 or 4 days of stimulation. No side effect (e.g. epilepsy) was reported. Our results demonstrate that repeated (5 days) anodal LDLPF tDCS is safe and might improve signs of consciousness in about half of patients in MCS. It is important to note that the first session is not predictive for a future positive effect of the efficacy of the non-invasive electrical stimulation. [less ▲]

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See detailFunctional analysis of FRD3 in Arabidopsis
Scheepers, Maxime ULg; Charlier, Jean-Benoit ULg; Spielmann, Julien ULg et al

Poster (2015, June)

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. The FRD3 (FERRIC REDUCTASE DEFECTIVE 3) protein, a member of the MATE family of ... [more ▼]

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. The FRD3 (FERRIC REDUCTASE DEFECTIVE 3) protein, a member of the MATE family of membrane transporters, is a citrate transporter involved in iron homeostasis and playing a role in zinc tolerance in Arabidopsis. The FRD3 gene displays a complex regulation. Alternative transcript initiation for FRD3 determines two transcripts, which differ in their 5'UTRs and have differential translation efficiency. The two transcripts are selectively regulated under stress conditions: iron and zinc depletion, zinc excess or cadmium presence. We are aiming to determine the FRD3 function in zinc and iron homeostasis in Arabidopsis. We will present data (i) on the functional characterization of the alternative transcripts and their role in metal homeostasis in Arabidopsis and (ii) on the zinc phenotypes of the frd3 mutant. [less ▲]

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See detailNonlinear Interpolation on Manifold of Reduced Order Models in Magnetodynamic Problems
Paquay, Yannick ULg; Bruls, Olivier ULg; Geuzaine, Christophe ULg

Poster (2015, June)

Proper Orthogonal Decomposition (POD) is an efficient model order reduction technique for linear problems in computational sciences, recently gaining popularity in electromagnetics. However, its ... [more ▼]

Proper Orthogonal Decomposition (POD) is an efficient model order reduction technique for linear problems in computational sciences, recently gaining popularity in electromagnetics. However, its efficiency has been shown to considerably degrade for nonlinear problems. In this paper, we propose a reduced order model for nonlinear magnetodynamic problems by combining POD with an interpolation on manifolds, which interpolates the reduced bases to efficiently construct the desired solution. [less ▲]

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See detailA web-based support system of the Belgian Register for Assisted Procreation
Gillain, Nicolas ULg; Bogaerts, Kris; Albert, Adelin ULg et al

Poster (2015, June)

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See detailCyber-pédopornographes : fixation pédophilique et Internet, une alternative à risque ?
Glowacz, Fabienne ULg; Galligani, Lucas; Hennen, Clarisse

Poster (2015, June)

La consommation de pédopornographie est un thème de recherche récent faisant suite à l’intérêt scientifique et clinique porté à la délinquance sexuelle. La question des rapports entre l’existence d’une ... [more ▼]

La consommation de pédopornographie est un thème de recherche récent faisant suite à l’intérêt scientifique et clinique porté à la délinquance sexuelle. La question des rapports entre l’existence d’une fixation pédophilique, la consommation de pédopornographie et les passages à l’acte pédophilique a été abordée par plusieurs études (Bourke et Hernandez, 2009 ; Babchishin, Hanson et Herman, 2010 ; Corriveau et Fortin, 2014) et reste en débat. Selon l’article 383bis du code pénal belge, la pédopornographie consiste en des « emblèmes, objets, films, photos, diapositives ou autres supports visuels présentant des mineurs d’âge dans des positions à caractère sexuel ». Cependant, le point de vue légal ne permet pas de prendre en considération tous les supports que peuvent utiliser les pédopornographes. En effet, certains amateurs trouveront satisfaction dans des contenus non-pornographiques. Dès lors, une typologie des images utilisées par les amateurs de pornographie enfantine a été mise en place par Taylor, Holland et Quayle (2001), sous le nom de COPINE Scale, reprenant dix catégories d’images pouvant être consultées ou téléchargées par les amateurs. Il existe différents lieux sur l’Internet sur lesquels ces supports se trouvent, le plus important étant les groupes de nouvelles, mais aussi plusieurs systèmes, comme que le peer-to-peer, dans lesquels les échanges de telles images s’opèrent. Plusieurs typologies ont été élaborées (Fortin et Roy, 2003 ; Delmonico et Griffin, 2008 ; Davidson, 2008 ; Corriveau et Fortin, 2011) identifiant divers profils : collectionneurs, distributeurs, abuseurs, producteurs et commerçants. Dans le cadre de notre recherche, à partir d’entrevues menées avec 9 sujets consommateurs de pédopornographie (âgés entre 29 et 60 ans) consultant au centre de santé mentale SYGMA, équipe de santé spécialisée, (8 d’entre eux dans le cadre d’une mesure judiciaire), nous avons exploré plusieurs dimensions pouvant être associées aux conduites de consommation de pédopornographie : l’addiction à internet, la présence d’une fixation pédophilique, la tendance à l’ennui, l’impulsivité et la recherche de sensation, la présence d’un soutien social ainsi que le rôle de sous-cultures pédopornograhiques. Au niveau méthodologique, nous avons adopté une approche mixte basée sur un entretien semi-structuré et la passation de tests (Echelle de provision sociale, Caron, 1996 ; Echelle de disposition à l’ennui, Gana et Akrmi, 1988 ; Implusive Behavior Scale, Whiteside et Lynam, 2001 ; Mesure de l’intensité des conduites addictives appliquée à l’internet, Décamps, Battaglia, et Idier, 2010) et sur une analyse du dossier clinique comprenant les jugements, les avis motivés et les entretiens cliniques. Nos résultats indiquent que la fixation pédophilique pouvait être un moteur de la consommation sans pour autant être présente chez tous les sujets. La tendance à l’ennui est une dimension peu signifiante dans la dynamique de consommation. Ce sont le manque de soutien social et l’insatisfaction affective et sexuelle qui se retrouvent au centre des dynamiques de la consommation pédopornographique de nos sujets. Isolés socialement et présentant un développement problématique sur le plan sexuel et affectif, c’est notamment par la consommation de pédopornographie que les sujets disent avoir trouvé une alternative. Cette consommation renvoie par ailleurs à un manque de contrôle social, offrant l’opportunité de consommer, ainsi qu’une impossibilité d’identifier un partenaire sexuel. L’Internet sera alors vu comme un outil permettant de répondre à ces difficultés sexuelles, sans pour autant qu’il n’y ait de comportement addictif. [less ▲]

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See detailOn the relationship between gray matter and behavioral data: lessons learned
Genon, Sarah ULg; Wensing, Tobias; Hoffstaedter, Felix et al

Poster (2015, June)

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See detailEmpowering NGS technologies for the study and diagnostic of plant viruses - European COST Action FA1407
Massart, Sébastien ULg; Gentit, Pascal; Olmos, Antonio et al

Poster (2015, June)

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See detailReduced Order Model for Accounting for High Frequency Effects in Power Electronic Components
Paquay, Yannick ULg; Geuzaine, Christophe ULg; Hasan, Md. Rokibul et al

Poster (2015, June)

This paper proposes a reduced-order model of power electronic components based on the proper orthogonal decomposition. Starting from a full-wave finite-element model and several snapshots/frequencies, the ... [more ▼]

This paper proposes a reduced-order model of power electronic components based on the proper orthogonal decomposition. Starting from a full-wave finite-element model and several snapshots/frequencies, the reduced-order (RO) model is constructed. Local field values (e.g. magnetic flux density, electric current density, magnetic or electric field) and global quantities (e.g. characteristic complex impedance, joule losses) can be determined for the intermediate frequencies with a very low computational cost and high accuracy. Particular attention is paid to the choice of the most suitable snapshots by means of three different greedy algorithms, the performance of which is compared. We adopt an automatic greedy algorithm that depends only on the RO model. [less ▲]

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See detailCoherent backscattering in the Fock space of a disordered Bose-Hubbard system
Engl, Thomas; Dujardin, Julien; Tisserond, Emilie et al

Poster (2015, June)

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space [1]. This enhancement is robust with ... [more ▼]

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space [1]. This enhancement is robust with respect to variations of external parameters even though it represents a dynamical manifestation of the delicate superposition principle in Fock space. It is a genuine quantum many-body effect which lies beyond the reach of any mean-field approach. Using a semiclassical approach based on interfering paths in Fock space, we calculate the magnitude of the backscattering peak and its dependence on gauge fields that break time-reversal invariance. We confirm our predictions by comparing them to exact quantum evolution probabilities in Bose-Hubbard models, and discuss their relevance in the context of many-body thermalization. We furthermore propose a specific experimental setup in order to detect this many-body coherent backscattering phenomenon with ultracold bosonic atoms. [1] T. Engl, J. Dujardin, A. Argüelles, P. Schlagheck, K. Richter, and J. D. Urbina, Phys. Rev. Lett. 112, 140403 (2014). [less ▲]

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See detailCross-modal identification of six subregions within the left PMd and their functional characterization
Genon, Sarah ULg; Li, Hai; Fan, Lingzhong et al

Poster (2015, June)

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See detailUnravelling Cemip expression and functions in the auditory portion of the inner ear.
Czajkowski, Amandine ULg; Chariot, Alain ULg; Delacroix, Laurence ULg et al

Poster (2015, May 29)

The inner ear is a complex organ composed of the vestibular system – which is the balancing system – and the cochlea – which is the earing system. The cochlea is a coiled shape organ composed of three ... [more ▼]

The inner ear is a complex organ composed of the vestibular system – which is the balancing system – and the cochlea – which is the earing system. The cochlea is a coiled shape organ composed of three main structures: the spiral ligament sitting on top of the stria vascularis, the organ of Corti with sensory hair cells and supporting cells and the spiral ganglion composed of neurons and glial cells. After an auditory stimulus, the sound wave progresses in the scala media filled with endolymph and induces a stimulation of sensory hair cells. These cells then transmit the information to the spiral ganglion neurons connected to them. Of course, the correct ionic homeostasis of endolymph is required for a good sound wave transmission. This homeostatic function is assured by the stria vascularis and the spiral ligament. The alteration of one of the structures mentioned before induces deafness. Currently, numerous genes have been associated to this kind of hearing loss. In the present work, we focus our attention Cemip – also known as KIAA1199 – that has been associated to human hereditary neurosensory deafness. Indeed, three missense mutations consisting in non-synonymous amino acid changes (R187L, R187H and H783Y) have been associated to this form of deafness. Therefore we would like to understand the role of Cemip in the cochlea. For that we have analysed Cemip mRNA pattern of expression by in situ hybridization at different developmental stages on cochlear sections. It seems Cemip mRNA is not present in the auditory portion of the inner ear at early embryonic stage 14 (E14) while it is largely present at E17 in the spiral ganglion, in supporting cells of the organ of Corti and in the spiral ligament. This expression is maintained post-nattily until P7. At P21 the expression is restricted to the spiral lamina - an osseous structure surrounding the spiral ganglion. Our on going work is aimed at revealing the biological role of Cemip in the cochlea in conditional knock-out mice. [less ▲]

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See detailExecutive functions in normal aging: Impact of cognitive reserve and objective physical activity
Gilsoul, Jessica ULg; Simon, Jessica ULg; Collette, Fabienne ULg

Poster (2015, May 28)

It is now acknowledged that there exists a large inter-individual variability in age-related cognitive changes. According to Stern (2009), the cognitive reserve built up throughout the life span will make ... [more ▼]

It is now acknowledged that there exists a large inter-individual variability in age-related cognitive changes. According to Stern (2009), the cognitive reserve built up throughout the life span will make seniors more or less resilient to the deleterious effects of aging on cognition, with seniors having a high level of cognitive reserve being more prone to successfully cope with cognitive and neuronal changes. Currently, few studies have focused on the specific effects of different factors of cognitive reserve on cognition. Consequently, the objective of this study is to determine the impact of four determinants of cognitive reserve on executive functions in normal aging. Sixty-eight healthy participants aged 60 to 80 were enrolled. Regarding executive functions, Inhibition (Stroop test, Hayling test, TAP Incompatibility subtest), Shifting (TAP Flexibility subtest, Plus-Minus task), and Updating (Letter-Number Sequencing subtest from MEM III, Letter memory task, 2-back task) were assessed (Miyake et al., 2000). Cognitive reserve was measured by questionnaires assessing educational level, occupation, leisure activities and physical activity. Moreover, an accelerometer allowed quantitative measure of physical activity by recording body movements during two weeks. Group comparisons (p<0.05) showed that seniors with a high level of cognitive reserve (measured by a global composite z-score) have better updating abilities (Letter memory task and updating composite score). In order to test the influence of each cognitive reserve factor on executive functions, simple linear regressions (p<0.05) were performed. The results showed that the educational level accounts for a significant part of the variance in flexibility (TAP Flexibility) and updating (Letter-Number sequencing, 2-back and composite score). The occupational level accounts significantly for the variance of the updating composite score. Regarding the quantitative physical activity, the mean number of minutes per day in moderate or intense physical activity significantly predicted the updating composite score. These results indicate that the level of cognitive reserve is related to abilities in some executive tests, particularly updating abilities. Importantly, all aspects of cognitive reserve are not associated with the three executive processes. This indicates a specificity of the protective effect of cognitive reserve on executive abilities. [less ▲]

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See detailThe impact of ageing on episodic memory encoding: an fMRI study
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Poster (2015, May 28)

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear ... [more ▼]

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear to recruit prefrontal areas bilaterally when their encoding is successful, while in young adults this activation is found to be left-lateralized (b). In this study, we were interested in the differences between younger and older participant regarding cerebral activity during encoding depending on whether the item elicited recollection or familiarity during the recognition phase. Twenty young volunteers (aged 19 to 29 years old) and 19 older volunteers (aged 60 to 78 years old) were presented visual stimuli depicting objects. During a first fMRI session, they were asked to make a size judgement about them. Then, in a second phase, the subjects were shown the items previously encountered during the encoding phase, as well as distractors. Participants' task was to determine which one were new and which one were seen earlier. For the latter, they also performed a Remember-Know judgement. Data were analysed using SPM8, with an event design comparing modifications in cerebral activity between the two subjects groups during encoding (1) for the items leading to recollection during the recognition phase compared to those leading to familiarity, and (2) for the items associated with familiarity during the recognition phase compared to those which were not recognized. Results show that older adults display a heightened activity in the right middle frontal gyrus, medial cingulate and paracingulate left gyri as well as in the precuneus, bilaterally when they engage recollection processes. Given that activations in these areas did not correlate with performance, they could be interepreted either as dedifferentiation or as an attempt of the ageing brain to compensate for a less elaborate encoding. However, no increase of activity was associated with familiarity processes in older adults, possibly because they are less demanding regarding attentional resources. (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Duverne, S., Motamedinia, S., & Rugg, M. D. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cerebral Cortex, 19(3), 733-744. doi:10.1093/cercor/bhn122 [less ▲]

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See detailWork incapacity and chronic pain patients: Is there an impact of work incapacity on anxiety and depression?
Beaumel, Alexia; Vanootighem, Valentine ULg; Gillet, Aline ULg et al

Poster (2015, May 28)

In 2011, a report of the Federal Public Service have shown that 8.5% of the Belgian population suffers from chronic pains, which represents 938 300 belgian people (Berquin et al., 2011). These persistent ... [more ▼]

In 2011, a report of the Federal Public Service have shown that 8.5% of the Belgian population suffers from chronic pains, which represents 938 300 belgian people (Berquin et al., 2011). These persistent pains may result in functional limitations on both domestic and professional domains which may lead to temporary or permanently work incapacity (Faymonville et al., 2014). These incapacities may in turn cause a social withdrawal and a tendency to focus on pain (Berquin et al., 2011). Additionally, patients are prone to emotional modifications due to persistent pain (Ossipov et al., 2010). All of these factors may contribute in the emergence of anxiety and depressive symptoms. The present study examines the impact of type of work incapacities (at work, temporary incapacity and permanent incapacity) on anxiety and depression scores as a function of diagnoses (fibromyalgia, chronic pain syndrome, back pain, polyalgia). 123 patients suffering from chronic pain completed a measure of anxiety and depression (HADS), and a self-reported questionnaire of psychological and physical disability at work. We did not found any significant effect of type of work incapacities on anxiety and depression scores. Results present tables of frequencies to illustrate the social and professional situations of patients as a function of chronic pain diagnoses. [less ▲]

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See detailThe effect of ageing and encoding instructions on episodic memory
Hagelstein, Catherine ULg; François, Sarah ULg; Manard, Marine ULg et al

Poster (2015, May 28)

During ageing, a decline in episodic memory is observed, characterized by decreased recollection (a). In this study, we investigated the influence of encoding instructions, intentional or incidental, on ... [more ▼]

During ageing, a decline in episodic memory is observed, characterized by decreased recollection (a). In this study, we investigated the influence of encoding instructions, intentional or incidental, on the performance of younger and older adults during an episodic memory task. Twenty young volunteers (aged 18 to 30 years old) and 20 older volunteers (aged 61 to 72 years old) participated in this experiment. The stimuli consisted of 300 black-and-white drawings of common objects. The task comprised two steps. During the encoding phase, 100 items were presented once ("hard" condition) and 100 other items were presented twice ("easy" condition). During recognition, the items from the encoding phase were presented again, as well as 100 new items. In each age group, half of the participants received incidental encoding instructions (they had to make size judgements about the objects depicted) while the other half were explicitly asked to memorize the objects presented because they would be asked to recognize them later on (intentional encoding). During recognition, they performed a Remember-Know judgement for the items they believed they had seen earlier. We carried out ANOVAs in order to test for the influence of instructions, age group and number of repetitions of the items in one hand on the percentage of recollection and on the other hand on the percentage of familiarity (p<.05). Results show a significant effect of age, with more correct recollection responses in young adults, whereas more correct familiarity was found in older adults. Furthermore, it was found that the items presented twice lead to more recollection than those presented only once. Finally, these results also suggest that in the older group of participants, only for the items presented twice, intentional encoding instructions lead to more recollection and less familiarity. This finding is consistent with previous work showing that the elderly do not easily use elaborate encoding strategies, and that they need more support (here, a second exposition to the material) in order to perform a deep encoding when they are encouraged to do so with intentional learning instructions (b). (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Froger, C., Bouazzaoui, B., Isingrini, M., & Taconnat, L. (2012). Study time allocation deficit of older adults: the role of environmental support at encoding? Psychology and Aging, 27(3), 577-588. doi:10.1037/a0026358 [less ▲]

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See detailPsychopathy and emotions: would emotional distancing make more efficient in cognitive tasks?
Grandjean, Sylvie; Dehon, Hedwige ULg; Blavier, Adelaïde ULg et al

Poster (2015, May 28)

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See detailBorderline Personality Disorder through the Rorschach test
Rommes, Jennifer; Englebert, Jérôme ULg; Blavier, Adelaïde ULg

Poster (2015, May 28)

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See detailParental and romantic attachments in teen datings : different meanings in boys' and girls' intimacy
Courtain, Audrey ULg; Lepas, Jennifer; Boulard, Aurore ULg et al

Poster (2015, May 28)

First proposing a relational understanding of the child’s very first years, attachment theory has since then been taken into consideration in friendships and romantic relationships. Indeed, the internal ... [more ▼]

First proposing a relational understanding of the child’s very first years, attachment theory has since then been taken into consideration in friendships and romantic relationships. Indeed, the internal working models (IWM) built upon early interactions are to be used on and on in many other situations as guidelines to understand what is going on for the self, this particular other and their specific relationship. Different attachment styles are thus likely to develop: secure or insecure (anxious/preoccupied, avoidant/dismissive, fearful). Considering teen dating, attachment is deeply involved, especially for two reasons: first, a certain questioning, but also re-actualization, of the attachment to parents; second, a new kind of attachment, meaning the one to the romantic partner. These elements lead us to test hypotheses linking attachment to parents and attachment to romantic partners, but also linking these attachments to some teen dating characteristics, such as the age when first dating, the number of love relationships, the longest-lasting love relationship and the fear of intimacy. Our hypothesis was tested among 283 teenagers (mean age = 17.43) with two self-administered questionnaires (the Behavioral Systems Questionnaire and the Fear of Intimacy Scale). Our statistical analyses were made of Pearson Chi², Anova and Post-Hoc Fisher (LSD). We see three types of interesting results. First, there is a significant relationship between attachment (parental and romantic attachments) and the number of love relationships and the fear of intimacy. Second, these relationships are differently established once considered the attachment modalities. Third, gender differences appear, girls looking more influenced by their attachment style than boys. [less ▲]

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See detailMaternal representations, social context and substance abuse
Halin, Stéphanie ULg; Combe, Samantha; Glowacz, Fabienne ULg et al

Poster (2015, May 28)

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See detailRomantic relationship and delinquency : which desistance factor ?
Puglia, Rosa ULg; Lepas, Jennifer; Glowacz, Fabienne ULg

Poster (2015, May 28)

A large number of studies (Stouthamer-Loeber, Loeber, Wei, Farrington & Wikstrom, 2002) have shown that the quality of parent-child relationship influences delinquency behavior during adolescence. So, the ... [more ▼]

A large number of studies (Stouthamer-Loeber, Loeber, Wei, Farrington & Wikstrom, 2002) have shown that the quality of parent-child relationship influences delinquency behavior during adolescence. So, the poorer the quality of relationship between a parent and his child is, the higher the probability that the child adopts delinquent behavior. However, recent studies (Giordano et al., 2002 ; Laub et al., 1998 ; Meeus & al., 2004 ; Woordward et al., 2002) have questioned the persistence of this association when people involved in a romantic relationship. These research have shown that quality of parent-child relationship predict delinquency in adolescents and young adults who do not have an intimate partner. But in adolescents and young adults who have an intimate partner, quality of parent-child relationship becomes obsolete. To be involved in an intimate relationship leads to less delinquency. Furthermore, results are concordant with research about desistance from delinquency that have shown that marriage leads to less criminality (Forrest & Hay, 2011 ; Sampson & Laub, 1993). These studies (Meus & al., 2004 ; Sampson & Laub, 1993) specify that it is quality of relationship rather than simply being in a romantic relationship that have an impact on desistance from delinquency. From empirical research conducted with adolescents and young adults (N=283) aged from 16 to 22 years old, and from a clinical research, we have explored links between parental attachment, romantic attachment and delinquency. We wondered if romantic attachment promotes desistance from delinquency whatever parental attachment. Behavioral System Questionnaire (Wehner & Furman, 1999) and self-reported delinquency scale (Born & Gavray, 1994) have used in this context. It appears that most of the participants have been involved in a significant romantic relationship. This romantic relationship is mainly characterized by a secure attachment. So, it leads to less deviant behaviors. On the other hand, parental attachment does not lead to less deviant behaviors. It also appears that attachment style that one develops towards one’s parent is not unchangeable. Romantic relationship during adolescence and adulthood can bring emotional and relational modifications. [less ▲]

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See detailThe neural bases of proactive and reactive control processes in healthy aging
Manard, Marine ULg; François, Sarah ULg; SALMON, Eric ULg et al

Poster (2015, May 28)

Background. Research on cognitive control suggests an age-related decline in proactive control abilities (an anticipatory form of control) whereas reactive control (consecutive to conflict detection ... [more ▼]

Background. Research on cognitive control suggests an age-related decline in proactive control abilities (an anticipatory form of control) whereas reactive control (consecutive to conflict detection) seems to remain intact [1]. As proactive and reactive control abilities were associated to specific brain networks [2], this study investigated age-related effects on the neural substrates associated to each kind of control. Method. A modified form of the Stroop task was administered to 16 young and 16 older adults in an event-related fMRI experiment. In this version of the Stroop task, three different contexts were created: (1) a mostly congruent context (MC, inducing reactive control) with a majority of congruent items, (2) a mostly incongruent context (MI, inducing proactive control) with mainly interfering items, (3) a neutral context (MN) with mainly neutral items. Preprocessing and statistical analyses were performed with SPM8 (p<.001 uncorrected). Results. Behavioral results (p<0.05) indicated faster processing of interferent items in the MI than MC context in young participants only. With regard to neuroimaging data, the comparison of the two groups showed that the processing of interferent items in the MI context is associated to decreased activity in (mainly right-sided) frontal and temporal areas in the older group. On the contrary, in the MC context, increased activity was observed in bilateral frontal areas for older compared to younger participants. Discussion. Behavioral results confirm that older participants have difficulties with the implementation of proactive control that is associated to decreased brain activity (compared to young participants) in areas underlying Stroop performance. However, the recruitment of supplementary frontal areas we observed in the reactive control condition suggests compensation processes. So, aging seems to differentially affect the neural networks associated to the various kinds of cognitive control. [less ▲]

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See detailContributing to wood anatomical databases to improve species identification, phylogeny and functional trait research in Central Africa
Morin, Julie ULg; Fayolle, Adeline ULg; De Ridder, Maaike et al

Poster (2015, May 26)

Central African rainforests shelter a high number of woody species that are anatomically very different. Knowledge of taxon-specific wood anatomical features has proven indispensable for scientific and ... [more ▼]

Central African rainforests shelter a high number of woody species that are anatomically very different. Knowledge of taxon-specific wood anatomical features has proven indispensable for scientific and non-scientific applications. The field of wood anatomy and identification has been drastically revolutionized by the development of internationally recognized lists of precisely illustrated microscopic features (e.g. IAWA Committee 1989), together with the launch of InsideWood, an online search database using these features to narrow down identification results (e.g. Wheeler 2011). However, despite these massive efforts, the anatomy of many species or even genera remains in the dark, especially in species-rich regions. Wood anatomy has been formally described for less than 25% of the Central African woody species (Hubau et al. 2012), the focus has been mainly on timber species and variations in wood anatomical structure remain to be explored. Therefore, we are assembling a wood anatomical database of about 800 species covering the Guineo-Congolian region using material from InsideWood and the Tervuren xylarium (new descriptions). As such, we present how large anatomical databases hold interesting perspectives for (i) wood and charcoal identification, (ii) exploring the phylogenetic signal of wood anatomy, and (iii) the relationship between wood anatomical features and functional traits. [less ▲]

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See detailFingerprint profiling of polysaccharide kefiran extracted from kefir grains by high-performance thin – layer chromatography
Pop, Carmen; Rotar, Ancuţa M.; Salanțӑ, Liana C. et al

Poster (2015, May 24)

Kefiran is a microbial and water-soluble polysaccharide obtained from the flora of kefir grains. It contains approximately equal amount of D - Glucose and D - Galactose, which could improve the viscosity ... [more ▼]

Kefiran is a microbial and water-soluble polysaccharide obtained from the flora of kefir grains. It contains approximately equal amount of D - Glucose and D - Galactose, which could improve the viscosity and viscoelastic properties of dairy products. Kefiran has some functional advantages such as antibacterial, antifungal and antitumor properties, it is often used in the food industry as a texturing and gelling agent. The matrix of kefiran can produce films with good appearance and satisfactory mechanical properties; it appears to have excellent potential as a film-forming agent and it can be an affordable alternative to synthetic packaging in food applications. [less ▲]

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See detailLipid Abnormalities Remain High among Treated Hypertensive Patients with Stable CHD: Results of the Dyslipidemia International Study (DYSIS) II Belgium
Guillaume, Michel; Weber; De Sutter, Johan et al

Poster (2015, May 23)

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See detailGene-based replication strategy and meta-analysis in the context of epistasis: application for Alzheimer’s disease.
Gusareva, Elena ULg; van der Lee, Sven; Katsumata, Yuriko et al

Poster (2015, May 22)

Although the discovery of biological epistasis via statistical methods remains a big challenge, large-scale epistasis studies have become more and more popular nowadays. Considering the power of genome ... [more ▼]

Although the discovery of biological epistasis via statistical methods remains a big challenge, large-scale epistasis studies have become more and more popular nowadays. Considering the power of genome-wide association interaction analysis (GWAI) is conceptually lower when comparing to GWA using the same data, the genome-wide screenings for epistasis often ends with no statistically significant findings. Therefore, sound meta-analytic methodologies for combining evidence across independent gene-gene interaction studies, taking into account characteristics of individual studies, as well as protocols for good standard practice of meta-GWAI analysis are missing so far. The existing methodologies, whereas is suboptimal, may still be the first choice in meta-GWAI. In our study, the genome-wide significant interaction between two var¬¬iants of WWC1 and TLN2 genes were first discovered in males of EADI1 of Alzheimer’s disease (AD) case/control cohort. Adopting the gene-based replication approach recently advocated by Gusareva and Van Steen (Hum Genet 2014), we assessed association between all available variants from the pair of genes to test for pair-wise interactions in three independent AD replication cohorts (GERAD1, AD cohort from Rotterdam study - RS, and ADGC). Particularly, we used regression modeling with co-dominant coding of genetic markers (the one that was found to be the most powerful to identify epistasis and gives the least false positive results) and taking into account possible confounding factors (age and the first four PCs). We further meta-analyzed p-values for the interaction effects across all pairs of markers in males and females using Fisher summary test statistic. For the most interesting epistasis signal that occur in males of EADI1 cohort and two replication cohorts (RS and ADGC), we also conducted multi-locus genotype (MLG) association analysis (quantifies effects sizes of each of eight multilocus genotypes derived from the SNPs-pair versus the reference category - homozygous for the major alleles) and then met-analyzed results using the random effect or fixed effect models depending on presence of heterogeneity between studies. Adopting this approach we statistically replicated the interaction between WWC1 and TLN2 genes. Although, the biological validation of this finding is still ahead, we can already demonstrate effectiveness of the adopted meta-analysis pipeline to identify novel genetic factors potentially predisposing to AD. [less ▲]

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See detailElectron paramagnetic resonance and fluorescence studies on potential anticancer properties of two new Ru(II) complexes : preliminary results
Collienne, Simon ULg; Terrak, Mohammed ULg; Mouithys-Mickalad, Ange ULg et al

Poster (2015, May 22)

Fight against cancer is a priority of today’s research. Since the discovery of the anticancer properties of cisplatin (CisPt) in 1965 by Rosenberg [1], the treatment of cancer by chemotherapy has known ... [more ▼]

Fight against cancer is a priority of today’s research. Since the discovery of the anticancer properties of cisplatin (CisPt) in 1965 by Rosenberg [1], the treatment of cancer by chemotherapy has known great improvements. Unfortunately, CisPt has several side effects and is not effective against all kinds of cancer. Nevertheless its use highlights the great potential of organometallic compounds in the treatment of cancer [2]. Here we investigated the potential anticancer properties of two new organometallic compounds based on ruthenium II : [RuCl(p-cymene)(S2C.IDip)]+(PF6)- and [RuCl(p-cymene)(S2C.ICy)]+(PF6)-, named as LDO436 and LDO437 respectively. [less ▲]

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See detail"Tell me about Self." Clarté de soi et souvenirs définissant le soi: Particularités du self chez des individus souffrant d'un trouble de l'humeur
Boulanger, Marie ULg; Wagener, Aurélie ULg; Blairy, Sylvie ULg

Poster (2015, May 21)

The present study focusses on a particular kind of autobiographical memories called self-defining memories (SDMs). SDMs are highly pertinent for self-building because they help to define in the most ... [more ▼]

The present study focusses on a particular kind of autobiographical memories called self-defining memories (SDMs). SDMs are highly pertinent for self-building because they help to define in the most clearly way our perception of ourselves. If literature showed that depressed and bipolar patients suffer from autobiographical memory (AM) disturbances, SDMs have not been studied a lot since yet in these two disorders. Then, the present study pursues two main aims: (1) to assess SDM’s characteristics and (2) to assess the relationship between the ability to retrieve SDM’s and self-concept clarity. To reach our objective, 17 depressed and 16 bipolar patients are compared to 17 healthy subjects. Participants are asked to complete SDMs procedure that is recalling six important events which happened in their life. These SDMs are assessed on four variables: specificity, impact, valence, meaning making, contain. Self-concept clarity and mood are also assessed. Preliminary results do not highlight difference between our groups on specificity. Marginal effects appear for meaning making with healthy subjects recalling more meaning making events. Results show that depressed patients present a mood congruence. The final results will be presented during the convention, as data-collection is on-going and will end in April. Experimental and clinical implications of our results will be discussed. [less ▲]

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See detailCombining remote sensing and ancillary data to improve species distribution models
Delangre, Jessica ULg; Radoux, Julien; Jacquemin, Floriane ULg et al

Poster (2015, May 21)

Correlative distribution models are increasingly used in biological conservation. They often require the compilation of various environmental attributes (climate, topography, land cover,…), which can be ... [more ▼]

Correlative distribution models are increasingly used in biological conservation. They often require the compilation of various environmental attributes (climate, topography, land cover,…), which can be very time-consuming. In the Lifewatch project, a database combining segmentation in homogeneous landscape units (“ecotopes”) and environmental attributes derived from regularly updated remote sensing data (land cover, potential solar energy,…) and other data sources (climate, topography,…) has been designed. Our aim was to assess the usefulness of this database for species distribution modelling and to propose further improvements. The distribution of ten species (four butterflies, three birds, two reptiles and one mammal) was modelled across Wallonia and model performance was assessed by Area Under the ROC Curve using the subsample approach. The models derived from ecotope segmentation and quantitative land cover attributes were compared to those obtained with a corresponding grid and a qualitative land cover database. The usefulness of ancillary data (soil properties, contextual attributes) was assessed to decide which variables should be integrated in the ecotope database. The results allowed us to assess and improve the relevance and accuracy of our database, which is a promising tool for species distribution modellers at the European scale. [less ▲]

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See detailThe impact of ageing on episodic memory encoding: an fMRI study
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Poster (2015, May 21)

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear ... [more ▼]

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear to recruit prefrontal areas bilaterally when their encoding is successful, while in young adults this activation is found to be left-lateralized (b). In this study, we were interested in the differences between younger and older participant regarding cerebral activity during encoding depending on whether the item elicited recollection or familiarity during the recognition phase. Twenty young volunteers (aged 19 to 29 years old) and 19 older volunteers (aged 60 to 78 years old) were presented visual stimuli depicting objects. During a first fMRI session, they were asked to make a size judgement about them. Then, in a second phase, the subjects were shown the items previously encountered during the encoding phase, as well as distractors. Participants' task was to determine which one were new and which one were seen earlier. For the latter, they also performed a Remember-Know judgement. Data were analysed using SPM8, with an event design comparing modifications in cerebral activity between the two subjects groups during encoding (1) for the items leading to recollection during the recognition phase compared to those leading to familiarity, and (2) for the items associated with familiarity during the recognition phase compared to those which were not recognized. Results show that older adults display a heightened activity in the right middle frontal gyrus, medial cingulate and paracingulate left gyri as well as in the precuneus, bilaterally when they engage recollection processes. Amongst those regions, the precuneus seems to underlie compensatory processes, allowing the elderly to perform a richer encoding, as it was previously suggested for recollection processes during recall (c). However, no increase in activity was associated with familiarity processes in older adults, possibly because they are less demanding regarding attentional resources. (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Duverne, S., Motamedinia, S., & Rugg, M. D. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cerebral Cortex, 19(3), 733-744. doi:10.1093/cercor/bhn122 (c) Angel, L., Bastin, C., Genon, S., Balteau, E., Phillips, C., Luxen, A., . . . Collette, F. (2013). Differential effects of aging on the neural correlates of recollection and familiarity. Cortex, 49(6), 1585-1597. doi:10.1016/j.cortex.2012.10.002 [less ▲]

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See detailMaladaptive emotion regulation strategies and stress sensitivity mediate the relation between adverse life events and attenuated psychotic symptoms.
Laloyaux, Julien ULg; Dessart, Gregory; Van der Linden, Martial ULg et al

Poster (2015, May 21)

Introduction There is now solid evidence for a relation between Adverse Life Events (ALE) and psychotic symptoms in both patients with psychosis and in the general population. A recent study has shown ... [more ▼]

Introduction There is now solid evidence for a relation between Adverse Life Events (ALE) and psychotic symptoms in both patients with psychosis and in the general population. A recent study has shown that this relation may be partially mediated by stress sensitivity. However, other factors that may mediate this relation, such as emotion regulation strategies, have not yet been examined in the literature. Objective The aim of this study was to assess the mediation effect of both emotion regulation strategies and stress sensitivity in the relation between ALE and attenuated positive psychotic symptoms in the general population. Results Results demonstrated that the relation between ALE and attenuated positive psychotic symptoms (i.e. hallucinations and delusions) was mediated by maladaptive emotion regulations strategies. Discussion Although it is most likely that there are several possible trajectories leading to the formation of positive psychotic symptoms, the results of the present study suggest that one such trajectory may involve the maladaptive regulation of negative emotions alongside a certain vulnerability after experiencing highly distressing ALE. Hence, interventions aiming to enhance adaptive emotion regulation strategies and diminish the utilization of maladaptive strategies should be regarded as an integral part of psychological treatment schemes in the context of psychotic symptoms. Conclusion In summary, the present study demonstrated that the relation between ALE and attenuated positive psychotic symptoms is mediated by maladaptive emotion regulation strategies. [less ▲]

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See detailCopperflora – an online species-level database of biology, ecology, geography of the flora from the Katangan Copperbelt (D.R. Congo) to manage their conservation
Boisson, Sylvain ULg; Seleck, Maxime ULg; Le Stradic, Soizig ULg et al

Poster (2015, May 21)

Storage and accessibility to structured data are essential in all fields of scientific research. In ecology, conservation managers regularly use thousands qualitative and quantitative data from different ... [more ▼]

Storage and accessibility to structured data are essential in all fields of scientific research. In ecology, conservation managers regularly use thousands qualitative and quantitative data from different partners and studies. In recent years, online databases concerning climate, species traits and distribution have been developed but few offer a comprehensive tool for the management of species conservation at several steps. The Copperflora database was created in order to include a diversity of informations about species (taxonomy, habitats, phenology, pictures, distribution, etc.) but also information concerning seeds collection, conservation, monitoring and tests applied to target species. Copperflora is meant to be an interactive and a dynamic project enhancing the exchange of data. Our project also contributes to the advance in the understanding of metallophyte communities’ conservation and restoration projects. Our database structure is expected to be easily transferable to other conservation actions. [less ▲]

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See detailAgroecology: Unity into diversity
Hatt, Séverin ULg; Artru, Sidonie ULg; Boeraeve, Fanny ULg et al

Poster (2015, May 21)

What does agroecology suggest ? Next to the theoretical agroecological principles, we present illustrative examples from farming practices, through the food system, up to the way of carrying agricultural ... [more ▼]

What does agroecology suggest ? Next to the theoretical agroecological principles, we present illustrative examples from farming practices, through the food system, up to the way of carrying agricultural research and education. [less ▲]

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See detailCARRIAGE OF CLOSTRIDIUM DIFFICILE IN HOSPITAL PATIENTS IN SPAIN, INCLUDING MOLECULAR CHARACTERIZATION AND ANTIMICROBIAL SUSCEPTIBILITY OF THE ISOLATES
Rodriguez Diaz, Cristina ULg; Taminiau, Bernard ULg; Van Broeck, Johan et al

Poster (2015, May 21)

Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI ... [more ▼]

Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, hospitalized patients are considered particularly vulnerable to CDI. The main objective of this study was to evaluate the prevalence of C. difficile in a Spanish hospital and to characterize the isolates with respect to the PCR-ribotype, antibiotic resistance and toxin activity. In addition, multilocus sequence typing (MLST) was performed in order to study clonal relationships between C. difficile isolates obtained from two different countries. Culture of samples was performed in a selective medium cycloserine cefoxitin fructose cholate. An identification of the isolated colonies was done by PCR detection of tpi, tcdA, tcdB and cdtA genes. Toxic activity was confirmed by a cytotoxic immunoassay. Further characterization was performed by PCR ribotyping. MLST was used in order to determine genetic relationships between Spanish and Belgian C. difficile isolates recovered from hospital patients in both countries. C. difficile was frequently detected in hospitalized patients. The isolates belonged to different PCR ribotypes, including type 027. Most of the strains obtained harboured tcdA and tcdB genes. The number of positive faecal samples considerably increased among elderly patients over 65 years old. The multi-locus sequence typing (MLST) analysis showed that some Spanish and Belgian isolates cluster in the same lineage. This study reveals the circulation of toxigenic C. difficile in a Spanish hospital. The relatedness between Belgian and Spanish isolates indicate a common source or a lack of diversity from some PCR-ribotypes. Moreover, data obtained suggest that the combination of ribotyping and MLST is a good tool for the inter-laboratory comparison of strains among different countries. Continuous inter-country surveillance is suitable to understand the spread of C. difficile isolates among hospitalized patients. [less ▲]

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See detailToxicity of several fungicides for orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae)
Chavalle, Sandrine ULg; Jansen, Jean-Pierre; San Martin y Gomez, Gilles et al

Poster (2015, May 19)

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae), can cause severe losses in wheat grain yield and quality. This pest is known to be susceptible to many insecticides ... [more ▼]

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae), can cause severe losses in wheat grain yield and quality. This pest is known to be susceptible to many insecticides, but various field observations have suggested that some fungicides could also significantly affect S. mosellana. In order to confirm these field observations, the effect on adult midges of several fungicides commonly applied to wheat crops was investigated in the laboratory and in small plots in the field. In each experiment, the fungicides were compared with a positive (insecticide) and a negative control (water). Four fungicides were assessed in the laboratory, each with five doses based on basis of a tenfold dilution starting at the field-recommended dose. The mortality rate was evaluated after 24 hours and the lethal dose 50% (LD50) was determined for each product. In the field, six fungicides were tested at the recommended dose. The effect of each product was compared on the basis of the number of S. mosellana adults caught alive with an insect vacuum sampler (Vortis®) on the morning after the treatments. Both experiments showed a significant effect of several fungicides tested on S. mosellana adults. Chlorothalonil was not toxic for S. mosellana, but tebuconazole, fluxapyroxad and azoxystrobin all induced significant mortality rates. [less ▲]

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See detailVolatile organic compounds emitted by Cavendish and Plantain banana plants
De Clerck, Caroline ULg; Kherkhofs, Celine; Berhal, Chadi ULg et al

Poster (2015, May 19)

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See detailThe influence of lithology on the mechanical strength and porosity of terra-cotta, the case study of Marrakech region (Morocco).
El Boudour El Idrissi, Hicham ULg; Daoudi, Lahcen; Collin, Frédéric ULg et al

Poster (2015, May 19)

The ceramic pastes in Marrakech region are prepared on the base of six types of raw materials of different lithologies. Various products are manufactured. The production consists of cooking utensils ... [more ▼]

The ceramic pastes in Marrakech region are prepared on the base of six types of raw materials of different lithologies. Various products are manufactured. The production consists of cooking utensils (based on schist, colluviums, quartzose sand and silt), decoration products (based on argillite, washing residues and soil), vases and gourds products (based on schist and soil), tiles (based on silt decantation) and traditional dishes (based on soil and argillite). In this study we elaborate bricks from the different raw material and we evaluate some of their physical properties after firing at 1050°C. In particular we measure the porosity to water and the mechanical strength of all the fired bricks. The aim is to compare the final product quality according to the origin (lithology) of the clayey raw material of the ceramic pastes. Based on our experiments, the bricks of the lower compressive strength (CS) and of the lower flexural strength (FS) are those based on sand (CS = 39 MPa; FS = 7 MPa), on silt decantation (CS = 25 to 39 MPa; FS = 10 to 18 MPa), and on schist and colluviums (CS = 20 to 51 MPa; FS = 6 to 17 MPa). Those of the highest values are based on argillites (CS = 33 to 102 MPa; FS = 13 to 28 MPa). The other pastes are characterized by intermediate values. The porosity ranges between 5 to 27%. The bricks based on silt decantation have the greatest values (20 to 27%), whereas those based on argillite have the lower values (5 to 10%). Those physical properties are, in most cases, in agreement with the requested values of the bricks industry. We conclude that such raw materials have high perspective to manufacture structural products of high performance in mechanical strength and thermal insulation. [less ▲]

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See detailStudy of essential oil activity on Curvularia sp. a rice leaf spot pathogen in Madagascar
Mamiharisoa Razanakoto, Léa ULg; Parisi, Olivier ULg; Massart, Sébastien ULg et al

Poster (2015, May 19)

Rice leaf spot have been observed on many fields during survey of rice diseases in three regions in Madagascar. Curvularia sp. was the most frequently isolated pathogen from the most severe diseased ... [more ▼]

Rice leaf spot have been observed on many fields during survey of rice diseases in three regions in Madagascar. Curvularia sp. was the most frequently isolated pathogen from the most severe diseased samples. This pathogen has been reported worldwide to cause important losses. Then in this work, we study the possibility to develop an alternative method to control Curvularia sp. Plants or plant extracts have been traditionally used to control human and plant diseases. Nowadays, the problem of residues of phytopharmaceutical products, reinforce the need for research on the development of natural plant extracts to control plant diseases. Madagascar has many endemic plants of interest. The antimicrobial properties of essential oils from Malagasy aromatic plants were evaluated. The main steps of this study are (i) the in-vitro screening of 39 Malagasy essential oils to control this pathogen, (ii) the evaluation of the phytotoxicity (on rice plants) of the efficient essential oils and (iii) the in vivo test of the activity of these non phytotoxic essential oils on Curvularia sp. on rice seedlings. The activity of essentials oils on Curvularia sp. has been tested in vitro during a microscale ELISA plate bioassay using optical density for a rapid evaluation of the biofungicidal activity of the extracts. Essential oils that showed interesting antifungal effect on this pathogen were tested for their phytotoxicity on rice plants. Briefly, one to two drop(s) of essential oils were applied on 3 leaves leaves of three weeks rice seedling. Six essential oils over the 39 tested showed an interesting antifungal activity with a percentage of growth inhibition greater than 70%. Three essential oils tested were phytotoxic as they induced necrotic spots on rice leaves after 48 h. Among three essential oils left, one of them showed an important effect when applied on rice seedling inoculated with a conidial suspension of Curvularia sp. These results confirmed that some essential oils present an antifungal activity. And even some of them are phytotoxic on rice plants, some essential oils show interesting potential to be an alternative method against rice diseases. [less ▲]

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