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See detail. Study of Neuronal Preconditioning by ESR
Guelluy, Pierre-Henri ULg; Hoebeke, Maryse ULg

Poster (2007, April)

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detailInfluence of collar design on palatal implant primary stability
Bolland, Fabrice; Ronco, Vincent; LAMBERT, France ULg et al

Poster (2007, April)

Detailed reference viewed: 52 (0 ULg)
See detailDatation par luminescence des terres cuites architecturales : étude de briques de l’abbaye de St Philbert de Grandlieu (44, France)
Blain, Sophie ULg; Guibert, Pierre; Vieillevigne, Emmanuelle et al

Poster (2007, April)

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See detailDetermination of COF2 vertical distributions above Jungfraujoch by FTIR and multi-spectra fitting
Duchatelet, Pierre ULg; Mahieu, Emmanuel ULg; Demoulin, Philippe ULg et al

Poster (2007, April)

The major sources of fluorine in the stratosphere are CFC-11 and CFC-12. Photolysis of these compounds leads to release of chlorine atoms, while the fluorine is, in a first step, present in the form of ... [more ▼]

The major sources of fluorine in the stratosphere are CFC-11 and CFC-12. Photolysis of these compounds leads to release of chlorine atoms, while the fluorine is, in a first step, present in the form of carbonyl compounds like COClF and COF2. Their further photolysis liberates fluorine atoms, which are quickly converted to HF. Given its long life time, COF2 is the second stratospheric fluorine reservoir. The first COF2 vertical distributions were derived from occultation measurements performed by the ATMOS instrument during the SPACELAB-3 Space Shuttle mission in 1985. The Canadian FTIR spectrometer ACE-FTS, onboard the SCISAT-1 satellite, is the first instrument since the last ATMOS flight in 1994, to record COF2 vertical profiles from space. All these observations show that, at mean latitudes, COF2 concentration is maximum between 30 and 35 km. Several COF2 IR absorption lines located either in the so-called InSb (1-5 µm) and MCT (2-16 µm) spectral ranges can be used to determine its total column from ground-based FTIR observations. In this context, several studies concerning the evolution of COF2 total column above various stations were published during the nineties. At this time, no study concerning the inversion of COF2 vertical distributions from ground-based FTIR spectra has been published. This report deals with the feasibility of such inversions, using, simultaneously, via the SFIT-2 v3.91 algorithm, a multi-microwindows and a multi-spectra fitting procedure. The multi-spectra method consists of combining several FTIR observations, recorded during the same day, to increase the information content. A selection of microwindows in InSb and MCT ranges, a complete discussion about the data characterization (e.g. information content) and typical examples of COF2 retrieved profiles from high resolution solar spectra recorded with the University of Liège Jungfraujoch FTS will be revealed. [less ▲]

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See detailMeasured and modelled trends of stratopsheric Cly and Fy column amounts in the northern hemisphere
Ruhnke, Roland; Blumenstock, Thomas; Duchatelet, Pierre ULg et al

Poster (2007, April)

Reactive inorganic chlorine plays a crucial role in the stratospheric ozone depletion. To stabilize and enable a recovering of the stratospheric ozone layer, the Montreal protocol and its amendments and ... [more ▼]

Reactive inorganic chlorine plays a crucial role in the stratospheric ozone depletion. To stabilize and enable a recovering of the stratospheric ozone layer, the Montreal protocol and its amendments and adjustments have been progressively implemented to reduce or even stop the production and emission of important chlorinated source gases (CFCs, HCFCs, CCl4, CH3CCl3, and Halons). As these source gases are photolysed in the stratosphere into inorganic chlorine and fluorine, respectively, the turn over of the inorganic chlorine (HCl and ClONO2) and slowing down of fluorine (HF and COF2) reservoirs act as a verification of the effectiveness of these protocols. Here we present results of long-term measurements of the stratospheric column of HCl, ClONO2, and HF obtained at different stations in the northern hemisphere (Ny Alesund, Kiruna, Zugspitze, Jungfraujoch, Izana, all affiliated to the NDACC, Network for the Detection of Atmospheric Composition Change) within the PEP (Pole- Equator-Pole) network. These time series are interpreted with model calculations performed with a state of the art 2-D model and the 3-D CTM KASIMA with respect to the determination of the slowing down or turn over, respectively. In addition, trend parameters calculated using different approaches (e.g. linear trend, bootstrap-method) will be presented and intercompared. [less ▲]

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See detailApproaches for retrieving abundances of methane isotopologues in the frame of the AGACC project from ground-based FTIR observations performed at the Jungfraujoch
Duchatelet, Pierre ULg; Mahieu, Emmanuel ULg; Demoulin, Philippe ULg et al

Poster (2007, April)

This work has been performed within the frame of AGACC(http://www.oma.be/AGACC/Home.html), a contribution to the Belgian Scientific Support for a Sustainable Development. The project intends to make an ... [more ▼]

This work has been performed within the frame of AGACC(http://www.oma.be/AGACC/Home.html), a contribution to the Belgian Scientific Support for a Sustainable Development. The project intends to make an advanced exploitation of existing ground-based remote-sensing measurements for a selection of atmospheric species that play an important role in the chemistry of the atmosphere and that have a direct or indirect impact on climate. Target species include -among others- lower tropospheric aerosols, H2O, HDO, CH4, HCN and CO. The instrumentation includes 3 types of spectrometers (FTIR, MAXDOAS and Brewer) and one CIMEL sun photometer. These instruments are operated at 3 different sites (Jungfraujoch, Ile de la Réunion and Uccle) and most of them are affiliated with the Network for the Detection of Atmospheric Composition Change (NDACC, formerly NDSC - http://www.ndacc.org), a group dedicated to performing high-quality long-term observations. This contribution will deal with the detection of the isotopologues of methane, a species released to the atmosphere by natural processes (e.g. wetlands, termites) as well as by anthropogenic activities (e.g. fossil fuel exploitation, rice agriculture, biomass burning, etc). Due to its high warming potential and its relatively long chemical lifetime, atmospheric methane is a major greenhouse gas. Methane also affects climate by influencing tropospheric ozone and stratospheric water. The cycle of methane is complex and a thoroughly study of the sources and sinks of its main isotopologue, as well as the other isotopic species, is necessary to characterize it. Isotopic ratios are also useful to differentiate between various sources of atmospheric methane. To study the vertical distribution of methane isotopologues from the high resolution FTIR spectra recorded by the University of Liège instrument at the International Scientific Station of the Jungfraujoch (ISSJ; 46.5°N, 8.0°E, 3580m a.s.l., Swiss Alps), we have selected several 13CH4 lines distributed in the so-called InSb (1-5 µm) and MCT (2-16 µm) spectral ranges. A set of four microwindows has also been selected for the study of CH3D. Using the SFIT-2 v3.91 algorithm, vertical column abundances as well as low-resolution vertical distributions have been retrieved, adjusted from an a priori profile defined on a 41 layers scheme and derived from ACE-FTS space observations. The information content and first preliminary retrieval results will be presented. [less ▲]

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See detailProduction de pseudoparticules de norovirus humains et bovins et leur utilisation diagnostique
Mauroy, Axel ULg; Scipioni, Alexandra; Saegerman, Claude et al

Poster (2007, April)

Les norovirus sont des agents majeurs de gastroentérite humaine d’origine alimentaire et ceci à travers le monde entier. La contamination est habituellement oro-fécale. Les norovirus sont non enveloppés ... [more ▼]

Les norovirus sont des agents majeurs de gastroentérite humaine d’origine alimentaire et ceci à travers le monde entier. La contamination est habituellement oro-fécale. Les norovirus sont non enveloppés et ont un génome composé d’ARN monocaténaire de polarité positive d’approximativement 7,5 kb. Au sein de ce génome, trois cadres ouverts de lecture (ORFs) sont décrits. L’ORF 1 code pour une polyprotéine qui sera par la suite clivée pour donner les différentes protéines non-structurales. L’ORF 2 encode pour l’unique protéine de capside. Une protéine structurale mineure dont le rôle est encore peu caractérisé est encodée par l’ORF 3. Ces virus sont très résistants dans l’environnement et une infection peut survenir même avec une très faible dose infectieuse. Appartenant à la famille des Caliciviridae, le genre norovirus est composé de cinq génogroupes (G) et contient également des virus infectant les animaux (bovins, porcins, murins). L’impact des norovirus animaux et plus particulièrement des norovirus bovins peut être envisagé à travers un possible caractère zoonotique de ces virus ; ainsi ils pourraient par exemple être transmis à l’homme via des eaux d’effluent contaminées. L’étude des norovirus humains et bovins est encore à l’heure actuelle entravée par l’absence d’un système de culture cellulaire. Cependant différents systèmes d’expression protéique ont été utilisés afin d’exprimer la protéine de capside, celle-ci s’assemblant spontanément avec d’autres pour reformer des pseudoparticules virales ou virus-like particles (VLPs). Ces VLPs sont morphologiquement et antigéniquement semblables aux virus natifs. Le but de ce travail était dans un premier temps d’obtenir des VLPs de souches humaines et bovines. Les gènes codant pour la protéine de capside d’une souche humaine (H384) et d’une souche bovine (B309) ont été amplifiés par RT-PCR à partir d’échantillons de matières fécales collectés dans des laboratoires de diagnostic humain et vétérinaire. Ces gènes ont été séquencés et comparés grâce à des outils informatiques (Basic Local Alignment Search Tool, BLAST) à la banque de séquences déjà disponibles sur le site du NCBI. Nous avons pu déterminer que la séquence de capside de la souche H384 était proche de celle de la souche HuNV/Altenkirchen 140/01/DE, une souche de GII et de génotype 4 tandis que la séquence de la souche B309 était proche de celles de GIII et de génotpe 2 (groupe Newbury2). Des plasmides contenant les séquences des ORFs 2 de deux souches de norovirus humains de référence, la souche de Norwalk (GI) et celle de Hawaii (GII), ont été aimablement fournies par le Docteur Jan Vinjé (CDC, Atlanta, USA). Le système d’expression protéique baculovirus (Invitrogen) a été utilisé pour obtenir des VLPs. Brièvement, des cellules d’insecte des lignées Sf9 et H5 ont été infectées avec des baculovirus recombinants pour la protéine de capside des norovirus. Les VLPs ont été purifiées à partir des surnageants par ultracentrifugation sur un coussin de sucrose à 30% suivie d’une ultracentrifugation en gradient de chlorure de césium. Ce gradient a été fractionné et les différentes fractions ont été analysées pour la présence de la protéine de capside des norovirus par SDS-PAGE. Pour vérifier que les fractions positives contenaient bien des VLPs, les surnageants ont été observés en microscopie électronique. Nous avons ainsi obtenu des VLPs de norovirus de trois des cinq génogroupes décrits (GI, II et III). Ces VLPs ont été utilisées pour immuniser des souris afin de produire des anticorps monoclonaux et pour immuniser des lapins afin d’obtenir des anticorps polyclonaux. Nous avons pu aussi tester une banque de sérums bovins par ELISA pour la présence d’anticorps dirigés contre les souches de norovirus de génogroupe III et de génotype 2, les plus fréquemment mises en évidence au sein de notre banque de matières fécales bovines. [less ▲]

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Peer Reviewed
See detailEvaluation of the cytotoxicity of cyclodextrins on endothelial cells using MTT assay
Castagne, Delphine ULg; Belhadj Salem, Leila; Delattre, Luc ULg et al

Poster (2007, April)

Detailed reference viewed: 24 (1 ULg)
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See detailOverview on the ADONIS Project: Accurate Diagnosis of prostate cancer using Optoacoustic detection of biologically functionalized gold Nanoparticles - A new Integrated Biosensor System
Fleron, Maximilien ULg; Schol, Daureen ULg; Greisch, Jean-François et al

Poster (2007, March 21)

Overview on the ADONIS Project: Accurate Diagnosis of prostate cancer using Optoacoustic detection of biologically functionalized gold Nanoparticles - A new Integrated Biosensor System

Detailed reference viewed: 15 (1 ULg)
Peer Reviewed
See detailPeculiar hydrophobic properties of the 67-78 fragment of α-synuclein are responsible for membrane destabilization and neurotoxicity
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Dupiereux-Fettweis, Ingrid ULg et al

Poster (2007, March 14)

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ... [more ▼]

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ago, tilted peptides have been detected in two other amyloidogenic proteins : the amyloid β peptide involved in Alzheimer’s disease, and the PrP protein linked to Creuztfeldt-Jakob’s disease. Tilted peptides are short protein fragments that adopt an oblique orientation when inserted into biological membranes. Tilted peptides are able to destabilize membranes. In this study, we predicted by sequence analysis and molecular modelling that the 67-78 fragment of α-synuclein is a tilted peptide. Like most of them, the α-syn 67-78 peptide is able to induce lipid mixing and leakage of unilamellar liposomes. A mutant designed by molecular modelling to decrease the destabilizing properties of the peptide was shown to be significantly less fusogenic. The neuronal toxicity was studied using human neuroblastoma cells and we demonstrated that the α-syn 67-78 peptide induces neurotoxicity. In conclusion, we have identified a tilted peptide in α-synuclein which could be involved in the toxicity induced during amyloidogenesis of α-synuclein. [less ▲]

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See detailCoccolithophorid calcium carbonate dissolution in surface waters
Harlay, Jérôme ULg; Koch, Craig; Young, Jeremy R et al

Poster (2007, March 06)

The role of calcifying organisms in the ocean biogeochemistry has been receiving increasing attention since CO2-related global change issues such as ocean acidification were pointed out by the scientific ... [more ▼]

The role of calcifying organisms in the ocean biogeochemistry has been receiving increasing attention since CO2-related global change issues such as ocean acidification were pointed out by the scientific community. The implications of changing oceanic pH in modifying ecosystems dominated by planktonic calcifiers have been shown by mesocosm and laboratory experiments based on CO2 manipulations. The major concern of such experiments focussed on variations in the rates of ecosystem primary production and calcification due to changes in algal physiology or specific composition. Our results, from an interdisciplinary survey of coccolithophore-dominated blooms in the northern Bay of Biscay (NE Atlantic), suggest that biogenic calcite dissolution is occurring in the photic zone where surface waters are oversaturated with respect to calcite. The dissolution of CaCO3 in surface waters, evidenced by scanning electron microscopy observations, has an impact on the preservation and export of carbon in coccolithophore-dominated ecosystems and on the exchange of CO2 across the ocean-atmosphere interface. Both aspects of suspended calcite concentration reduction in natural environments (lower rates of production or dissolution) could be considered as a perturbation of the oceanic carbon cycle. We aim at presenting here a biogeochemical description of processes, including integrated primary production, calcification, and parameters such as transparent exopolymer particles concentration and particulate inorganic carbon profiles, during field studies. A mechanism for calcite dissolution, based on biological activity in microenvironments (including grazing, bacterial respiration and DMS production) is presented as a conceptual model in coccolithophore blooms. [less ▲]

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See detailCalcification and transparent exopolymer particles (TEP) production in batch cultures of Emiliania huxleyi exposed to different pCO2
De Bodt, Caroline; d'Hoop, Quentin; Harlay, Jérôme ULg et al

Poster (2007, March 06)

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP ... [more ▼]

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP accumulate until the end of the experiment and are enhanced after nutrient exhaustion. TEP contribute significantly to POC concentrations after the exponential growth phase. The very good correlation between TEP and calcite concentrations suggests that the calcification acts as a potential source of TEP in coccolithophore blooms. Finally, an Ωcalcite of 3 seems to be necessary for Ehux to calcify. [less ▲]

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See detailThe role of deformation in the bouncing droplet problem
Terwagne, Denis ULg; Gilet, Tristan ULg; Dorbolo, Stéphane ULg et al

Poster (2007, March)

Detailed reference viewed: 11 (0 ULg)
See detailCO2 dynamics and related air-ice-sea gas transfer in spring pack and land fast sea ice,
Delille, Bruno ULg; Schoemann, V.; Lannuzel, D. et al

Poster (2007, March)

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See detailUse of exergy to detect and measure perturbations affecting Posidonia oceanica (L.) Delile meadows: Characterization in the sedimentary compartment
Pete, Dorothée ULg; Bouquegneau, Jean-Marie ULg; Gobert, Sylvie ULg

Poster (2007, March)

Within the scope of the European Water Framework Directive, it seems important to characterize state and evolution of marine ecosystems in a global way. So, it is proposed to use both thermodynamic ... [more ▼]

Within the scope of the European Water Framework Directive, it seems important to characterize state and evolution of marine ecosystems in a global way. So, it is proposed to use both thermodynamic indicators called exergy (Ex) and specific exergy (Exsp) in Posidonia oceanica meadows. Aims of this project are to detect and measure perturbations owed to nutrients loading and mechanical spoiling in the Mediterranean coastal zone. It will be led in the Bay of Calvi, on the microbenthic loop (organic matter, bacteria, microphytobenthos and meiofauna) and will be divided in two parts: sampling in different zone of the meadow and in situ experiments. In the end of this study, it will be possible to give a diagnostic on the health of P. oceanica meadow and to determine how this health will evolve, thanks to the introduction of the exergy in a model. [less ▲]

Detailed reference viewed: 36 (10 ULg)
See detailA role for the transcriptional complex elongator in cell migration and spreading
Creppe, C.; Close, Pierre ULg; Cornez, I. et al

Poster (2007, March)

Detailed reference viewed: 14 (3 ULg)
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See detailCarbon dioxide in European coastal waters
Borges, Alberto ULg; Schiettecatte, L.-S.; Abril, G. et al

Poster (2007, March)

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See detailPolyubiquitination of the scaffold protein tank/I-traf: implications for the TLR-mediated signalling pathways
Gatot, J. S.; Gioia, R.; Chau, Tieu-Lan ULg et al

Poster (2007, March)

Detailed reference viewed: 10 (4 ULg)
See detailBiogeochemical cycle in a coccolithophorid bloom
Suykens, Kim; Delille, Bruno ULg; Borges, Alberto ULg et al

Poster (2007, March)

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See detailPREDetector : Prokaryotic Regulatory Element Detector
Hiard, Samuel ULg; Rigali, Sébastien ULg; Colson, Séverine ULg et al

Poster (2007, February 15)

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The ... [more ▼]

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The emergence of position weight matrices based programs has facilitated the access to this approach. However, a tool that automatically estimates the reliability of the predictions and would allow users to extend predictions in genomic regions generally regarded with no regulatory functions was still highly demanded. Result: Here, we introduce PREDetector, a tool developed for predicting regulons of DNA-binding proteins in prokaryotic genomes that (i) automatically predicts, scores and positions potential binding sites and their respective target genes, (ii) includes the downstream co-regulated genes, (iii) extends the predictions to coding sequences and terminator regions, (iv) saves private matrices and allows predictions in other genomes, and (v) provides an easy way to estimate the reliability of the predictions. Conclusion: We present, with PREDetector, an accurate prokaryotic regulon prediction tool that maximally answers biologists’ requests. PREDetector can be downloaded freely at http://www.montefiore.ulg.ac.be/~hiard/predetectorfr.html [less ▲]

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, February 15)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailFirst-Principles Study of Thermal and Elastic Properties of Al2O3
Xu, Bin ULg; Dong, Jianjun

Poster (2007, February)

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See detailThe role of deformation in the bouncing droplet problem
Terwagne, Denis ULg; Gilet, Tristan ULg; Dorbolo, Stéphane ULg et al

Poster (2007, February)

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See detailProduire de la viande et du lait avec la Blanc-Bleu Belge de type mixte
Bastin, Catherine ULg; Mayeres, Patrick; Bertozzi, Carlo et al

Poster (2007, January 24)

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Peer Reviewed
See detailPreconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anti-cancer therapies
Martinive, Philippe ULg

Poster (2007, January)

Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O(2) diffusion-limited hypoxia, another form of tumor hypoxia characterized by ... [more ▼]

Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O(2) diffusion-limited hypoxia, another form of tumor hypoxia characterized by fluctuating changes in pO(2) within the disorganized tumor vascular network is described. Here, we postulated that this form of intermittent hypoxia promotes endothelial cell survival, thereby extending the concept of hypoxia-driven resistance to the tumor vasculature. We found that endothelial cell exposure to cycles of hypoxia reoxygenation not only rendered them resistant to proapoptotic stresses, including serum deprivation and radiotherapy, but also increased their capacity to migrate and organize in tubes. By contrast, prolonged hypoxia failed to exert protective effects and even seemed deleterious when combined with radiotherapy. The use of hypoxia-inducible factor-1alpha (HIF-1alpha)-targeting small interfering RNA led us to document that the accumulation of HIF-1alpha during intermittent hypoxia accounted for the higher resistance of endothelial cells. We also used an in vivo approach to enforce intermittent hypoxia in tumor-bearing mice and found that it was associated with less radiation-induced apoptosis within both the vascular and the tumor cell compartments (versus normoxia or prolonged hypoxia). Radioresistance was further ascertained by an increased rate of tumor regrowth in irradiated mice preexposed to intermittent hypoxia and confirmed in vitro using distinctly radiosensitive tumor cell lines. In conclusion, we have documented that intermittent hypoxia may condition endothelial cells and tumor cells in such a way that they are more resistant to apoptosis and more prone to participate in tumor progression. Our observations also underscore the potential of drugs targeting HIF-1alpha to resensitize the tumor vasculature to anticancer treatments. PMID: 17178869 [PubMed - indexed for MEDLINE] [less ▲]

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See detailCleft Palate (CP): not only a diagnosis in foals
Van Galen, Gaby ULg; Delguste, Catherine ULg; Verwilghen, Denis ULg et al

Poster (2007, January)

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Peer Reviewed
See detailL'utilité de l'association aripiprazole-méthylphénidate en pédopsychiatrie, selon les diagnostics
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Introduction : En pédopsychiatrie, les enfants présentent souvent des comorbidités. L'AD et/ou HD peut être associée à tous les diagnostics de la nosographie. Une diversité de diagnostics répond aux ... [more ▼]

Introduction : En pédopsychiatrie, les enfants présentent souvent des comorbidités. L'AD et/ou HD peut être associée à tous les diagnostics de la nosographie. Une diversité de diagnostics répond aux antipsychotiques atypiques et l'ADHD répond au méthylphénidate. Par contre, il n'existe aucune étude qui analyse l'effet simultané d'aripiprazole-méthylphénidate chez l'enfant. Objectifs : Établir le diagnostic des comorbidités chez les enfants et évaluer dans un suivi de cohorte : l'efficacité de l'association aripiprazole-méthylphénidate, les posologies et les effets secondaires. Méthode : Établissement des diagnostics des comorbidités chez 31 enfants, 22 garçons et 9 filles, de 5 à 12 ans (moy: 9,1 ans), suivis dans 2 Services de Santé Mentale. Les diagnostics sont établis selon: le DSM IV et les critères des Troubles de la Régulation des stimuli sensoriels de la « Classification des Diagnostics des Troubles de la Santé Mentale et du Développement de la Petite Enfance, DC:0-3R », 2005. Les posologies et effets secondaires sont évalués dans un suivi longitudinal de 8 mois en moy/enfant. Résultats : Comorbidités : ADHD (31) [AD (4), HD (2), mixte (25)], états paranoïdes (11), autres projections psychotiques (10), symptômes négatifs (10), bipolarité (25) [maniaque (10), mixte (13), dépressif (2)], colères en "on-off" (18), troubles de la régulation (17), autisme (2), somnambulisme (1). Aripiprazole-méthylphénidate est efficace dans l'ensemble de ces diagnostics. L'aripiprazole est efficace dans les Troubles de la Régulation ; ceci est une nouvelle indication thérapeutique. Posologie. Aripiprazole : 1,0 mg/10 kilos (min 0,8 et max 1,8 mg), 1 prise/j. Méthylphénidate : 7 mg/10 kilos/j (min 5 et max 10 mg). Arrêt de l'aripiprazole : 2 arrêts pour accroissement de l'agressivité, 1 arrêt pour augmentation de la sensibilité des perceptions avec peurs. Arrêt du méthylphénidate : 1 arrêt pour coliques abdominales. Arrêt du méthylphénidate et de l'aripiprazole : aripiprazole suite à une somnolence importante non dose dépendante et méthylphénidate suite à un accroissement de l'excitabilité non dose dépendante chez 1 enfant. Conclusion : L'association aripiprazole-méthylphénidate est très bien tolérée, avec un bénéfice additif lorsque l'enfant présente en comorbidité un AD et/ou HD (26). [less ▲]

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See detailL’aripiprazole chez les enfants de 5 à 12 ans : étude clinique. Indications, intérêt, posologie, effets secondaires
Scholl, Jean-Marc ULg; Philippe., Paule ULg

Poster (2007, January)

Introduction : Les antipsychotiques atypiques ont de tout autres propriétés que les neuroleptiques. Leurs indications comprennent de nombreux diagnostics "non psychotiques". Ils sont largement utilisés ... [more ▼]

Introduction : Les antipsychotiques atypiques ont de tout autres propriétés que les neuroleptiques. Leurs indications comprennent de nombreux diagnostics "non psychotiques". Ils sont largement utilisés chez les enfants. L'aripiprazole est le dernier venu des antipsychotiques atypiques et il est le premier agoniste partiel dopaminergique et sérotoninergique. Il a des propriétés originales dont les effets sont peu connus chez les enfants. Objectifs : Évaluer l'efficacité de l'aripiprazole selon les diagnostics, les posologies utiles et les effets secondaires dans un suivi de cohorte. Méthode : Étude transversale descriptive de 37 enfants, 25 garçons et 12 filles, âgés de 5 à 12 ans (moy: 8 ans 7 mois), suivis dans 2 Services de Santé Mentale. Les diagnostics sont établis selon: 1. le DSM IV et 2. les critères des Troubles de la Régulation des stimuli sensoriels de la « Classification des Diagnostics des Troubles de la Santé Mentale et du Développement de la Petite Enfance, (DC:0-3R, 2005) ». Une attention particulière est portée au diagnostic des comorbidités. Les posologies et effets secondaires sont évalués dans un suivi longitudinal de 8 mois en moy. par enfant. Résultats : L'aripiprazole est efficace dans les : états paranoïdes (14), autres projections psychotiques (10), symptômes négatifs (12), la bipolarité (25), les colères en "on-off" (18), les troubles de la régulation (21), l'autisme (3), le somnambulisme (2). Posologie thérapeutique : 1,0 mg/10 kilos (min. 0,8 et max 1,8 mg), 1 prise/j. Effets secondaires : nausées entre le Ier et le 10e jour (6), somnolence importante (2), augmentation de la sensibilité des perceptions durant les 4 premières semaines de traitement (4), accroissement de l'agressivité avec sentiments de persécution (2), épisodes de palpitations avec tachycardie (2). Arrêt du traitement : 2 arrêts pour somnolence importante non dose-dépendante (une enfant a une immaturité neurologique et l'autre une leucomalacie périventriculaire avec épilepsie), 2 autres arrêts pour accroissement de l'agressivité, et un 5e arrêt suite à des palpitations et tachycardie (examens cardiologiques normaux). L'association aripiprazole-méthylphénidate est très bien tolérée et apporte un bénéfice additif lorsque l'enfant présente en comorbidité un AD et/ou HD (26). [less ▲]

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See detailMiroir interne déformant de l'image de soi : élaboration conceptuelle intégrant la clinique et les découvertes récentes des neurosciences
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est ... [more ▼]

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est différent de celui qui permet au sujet de donner des attributs à d'autres individus. Le réseau référé au self permet d'être en contact immédiat avec l'image et la connaissance de soi. De plus, le rappel mnésique des attributs positifs et négatifs référés au self met en jeu des réseaux neuronaux différents. Les attributs positifs référés au self activent la région préfrontale antéromédiane droite, les attributs négatifs référés au self la région préfrontale dorsolatérale droite. Le sujet sain active les deux réseaux de façon simultanée pour restituer une image de soi intégrée. Définition conceptuelle: Le "miroir interne" – distingué de l'objet qui lui est présenté – correspond¬ au réseau neuronal référé spécifiquement au self. Ce réseau accède à l'image de soi. S'il y a un dysfonctionnement du réseau référé au self, il restitue une image déformée de soi, et le "miroir interne" devient déformant. Le sujet associera son identité à cette image déformée. Clinique du «miroir interne déformant de l'image de soi» : Le regard de l'enfant sur lui-même lui renvoie une image plus négative que ce que ses interlocuteurs ne perçoivent de lui. Dès le départ, l'enfant a une mauvaise perception de lui-même. Lorsqu'un interlocuteur lui fait une remarque, l'enfant bascule dans une image déformée et bien plus négative que celle que ne lui prête l'interlocuteur. Un dysfonctionnement de ces réseaux déséquilibre la balance et ne fait apparaître "qu'une seule couleur" dans le "miroir interne" par une restitution mnésique univoque : ou des attributs positifs, ou des attributs négatifs. Une prépondérance de l'image négative évoque un terrain dépressif, des personnalités évitante ou dépendante. Une prépondérance de l'image positive évoque des personnalités narcissiques, une image mégalomaniaque. Un dysfonctionnement neuronal peut induire une labilité et une instabilité de cette image (borderline), ou, une bascule rapide en "on-off" d'images positives et négatives de soi (rencontrée en pédopsychiatrie). Une psychoéducation permet la prise de conscience de ce miroir interne déformant. [less ▲]

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See detailUltrasonography and histology of equine menisci; a comparative study of the medial
De Busscher,V; Gabriel, Annick ULg; Cassart, Dominique ULg et al

Poster (2007, January)

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See detailLe "Mal-être en situation d'être seul" différencié de "l'Angoisse de séparation" : recherche sémiologique et élaboration conceptuelle
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Une recherche sémiologique sur 170 enfants a individualisé : le "mal-être en situation d'être seul". Un malaise apparaît lorsque le sujet est seul. Voici son décours développementale. Certains bébés ... [more ▼]

Une recherche sémiologique sur 170 enfants a individualisé : le "mal-être en situation d'être seul". Un malaise apparaît lorsque le sujet est seul. Voici son décours développementale. Certains bébés réclament une présence physique pour s'endormir. Vers 2,5 ans, l'enfant connaît une séparation difficile lors des premiers jours d'école. Vers 5 ans, l'enfant n'aime pas jouer seul dans une pièce sans la présence d'une autre personne ou d'un animal, et s'il le fait, il cherche à savoir en permanence où se trouve l'adulte. À l'endormissement, l'enfant appelle souvent, sort de la chambre. La nuit, il voudrait rejoindre les parents. Vers 8 ans, il n'aura pas de difficultés à quitter la maison et à se séparer de ses parents pour aller jouer avec des copains du quartier, mais il sera beaucoup plus mal à l'aise si l'un de ses parents quitte momentanément la maison. Vers 9 ans, la symptomatologie se limite à celle retrouvée chez l'adulte : un sentiment vague de mal-être à l'endormissement. L'adulte a des difficultés à mettre des mots sur ce ressenti qui est sans représentation : du "vide" ou un "rien". Il cherche à retarder la mise au lit, à s'occuper au lit pour éviter ce ressenti, et à s'endormir rapidement de fatigue. L'adulte qui ressent ce "mal-être" en journée va le contrer par 4 moyens : 1. activités 2. apport sensoriel (radios ouvertes, TV), 3. remplir son "monde interne" par la lecture 4. un animal de compagnie. Le "mal-être en situation d'être seul" : A) Est à distinguer de l'angoisse de séparation B) Est corrélé à un retard d'apparition des repères temporels, non pas séquentiels ou notionnels, mais dans l'appréhension subjective du temps : "goûter anticipativement ce que dure un certain laps de temps" C) Il serait lié à un manque d'efficience d'un support neurophysiologique permettant l'évaluation de la longueur du temps : "la jauge interne d'évaluation anticipative du temps" D) Ceci expliquerait qu'il ne suffit pas à l'enfant d'avoir des représentations pour acquérir le sentiment subjectif d'une permanence mais qu'il faut y joindre ce "feeling" du temps E) Il est systématiquement présent dans la bipolarité sans en être pathognomonique. Il se retrouve à l'état isolé et dans d'autres entités nosologiques. A minima, il est une caractéristique de la personne. [less ▲]

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See detailDisseminated Penicillium marneffei infection contrated in China
Hayette, Marie-Pierre ULg; Mukeba Tschialala, Didier; Meex, Cécile ULg et al

Poster (2007)

Penicillium marneffei infection is a rare fungal disease that cause significant disease in immunosuppressed patients. The geographical distribution of this dimorphic fungus is restricted to Asia ... [more ▼]

Penicillium marneffei infection is a rare fungal disease that cause significant disease in immunosuppressed patients. The geographical distribution of this dimorphic fungus is restricted to Asia, Southeast and Far East, where the disease is considered as an indicator of acquired immunodeficiency syndrome (AIDS). Case report. A 42-year old Congolese woman living in Lubumbashi was admitted at the university hospital of Liège for exploration of a general status impairment. She experienced for three months spiking fever, weight loss, productive cough with bloody expectorations and progressive dyspnoea. She reported also to have non-bloody mild diarrhoea with abdominal pain. The HIV antibody status was positive with a low CD4 T lymphocytes count (28/µl). Pulmonary infiltrates were visualized on chest radiography and the computed tomography revealed the presence of a severe pneumopathy characterised by bilateral micronodular lesions. Mediastinal polyadenopathies associated with hepato- and splenomegaly were also highlighted. Bronchoscopy was performed and bronchial aspirations revealed the presence of numerous leucocytes with the presence of intracellular Gram positive organisms suggestive of yeasts. Ziehl, Giemsa and Gomori-Grocott staining were also performed. Ziehl staining was negative. The morphological aspect given by Giemsa staining excluded infection and the PCR specific for T. gondii B1 gene was negative. However, Gomori-Grocott staining revealed the presence of intracellular oval, elongated, sausage-shaped cells with a single transverse septum (3 to 5 µm). Penicillium marneffei was isolated from blood culture and respiratory samples. Intraveinous amphotericin B treatment was administrated during 15 days followed by itraconazole oral administration (200 mg/j). The antimycotic treatment improved the patient condition and despite other clinical troubles she was prematurely discharged because of financial problems. Conclusion. Opportunistic agents involved in HIV-infected patients differ in Africa and Asia and it is important to be able to make a rapid diagnosis with the aid of an experienced laboratory. [less ▲]

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See detailEffect of base mutations in GC rich binding site on recognition by minor groove binding dications
Munde, M; Ismail, M; Peixoto, Paul ULg et al

Poster (2007)

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See detailStrained Si-on-insulator for advanced CMOS devices
Mantl, S.; Buca, D.; Zhao, Q. et al

Poster (2007)

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See detailDirecting the lipopeptide Mycosubtilin biosynthesis toward C17:0 branched isoform influences the expression of cspB and cspC in Bacillus subtilis
Guez, Jean-Sébastien; Drucbert, A.; Müller, C. et al

Poster (2007)

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See detailMechanisms of ATM regulation by TGF-beta
Paupert, Jenny ULg; Barcellos-Hoff, Mary-Helen

Poster (2007)

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See detailControlled release of drugs from an original multi-component device
Nizet, Dominique; Zalfen, Alina; Collard, Laurence ULg et al

Poster (2007)

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See detailPhotodegradation of bacteria with TiO2 produced by sol-gel method
Tasseroul, Ludivine ULg; Pàez Martinez, Carlos ULg; Braconnier, Benoît et al

Poster (2007)

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See detailGenome comparison of B. longum NCC-2705 and B. longum CRC-002 using suppressive subtractive hybridization
Delcenserie, Véronique ULg; lessard, Marie*-Helene; LaPointe, Gisele et al

Poster (2007)

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See detailAnalyse de l’évolution des plaines alluviales du massif ardennais grâce aux résidus de la sidérurgie ancienne
Houbrechts, Geoffrey ULg; Mols, Julien; Petit, François ULg

Poster (2007)

Dès la fin du XIVe siècle, des sidérurgistes installèrent leurs fourneaux et leurs affineries le long des cours d’eau du massif ardennais afin d’utiliser l’énergie hydraulique pour actionner les soufflets ... [more ▼]

Dès la fin du XIVe siècle, des sidérurgistes installèrent leurs fourneaux et leurs affineries le long des cours d’eau du massif ardennais afin d’utiliser l’énergie hydraulique pour actionner les soufflets et les marteaux des forges. De grandes quantités de scories, résidus de la sidérurgie ancienne, étaient produites lors de la transformation du minerai de fer en métal et étaient ensuite entassées à proximité des bâtiments, généralement sur les plaines alluviales. Ces éléments pouvaient donc être emportés par les crues débordantes ou par érosion des crassiers, se mélanger aux alluvions naturelles et se déposer en aval. Grâce aux études historiques, il est possible de dater de manière relativement précise les périodes de fonctionnement des différents sites sidérurgiques dans une vallée. Nous avons donc développé une méthode qui consiste à utiliser les concentrations en scories sidérurgiques comme traceur pour dater les dépôts fluviatiles, enfouis et conservés dans les plaines alluviales. Pour plusieurs rivières du massif ardennais, nous avons déterminé des taux de sédimentation moyens pour les derniers siècles et nous avons quantifié l’importance de la mobilité latérale des cours d’eau. Ces données sont particulièrement rares étant donné l’imprécision des cartes anciennes et des méthodes de datation pour cette période. [less ▲]

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See detailMG-63 Osteoblast Culture on Biodegradable Textiles for Bone Tissue Regeneration
Moniotte, Nicolas; Borget, Pascal; Pirotte, Fabrice et al

Poster (2007)

The primary aim of bone scaffold is to restore, maintain and improve the structure and properties of damaged bones. The scaffold acts as a 3-D template for guided tissue-engineering and provides an ... [more ▼]

The primary aim of bone scaffold is to restore, maintain and improve the structure and properties of damaged bones. The scaffold acts as a 3-D template for guided tissue-engineering and provides an excellent transition from in vitro to in vivo systems, avoiding auto- or allo-grafting treatments, both associated with serious limitations. The pore size of the scaffold must be large enough to allow cell migration and proliferation through the structure, but small enough to provide sufficient specific area for cell attachment. In this work, degradable poly(lactic acid) (PLA) yarns were knitted into complexes superstructures and evaluated as 3-D scaffold to promote cell bone reconstruction. PLA fabrics were knitted from multi-filaments in a double layer interlock structure to produce a weft knit. The fabrics are made of two porosities, one defined by the open space inside a loop (~1mm) and the second by the distance between the filaments (1-10 µm), with high control and reproducibility inherent to the manufacturing process. Human MG-63 osteoblast-like cells were seeded on PLA textiles and cell viability and proliferation were evaluated using MTS (tetrazolium salt) assays, DNA quantitative analysis (hoechst), fluorescence staining (acridine orange) and scanning electron microscopy. Alkaline Phosphatase activity in cell lysates was also investigated. After 3 days of culture, MG-63 fully expressed their fibroblastic phenotype. Although the number of cells was high, mitochondrial activity was shown to be reduced when cells are on the PLA fibres (compared to culture on a glass slide). This may be due the release of lactic acid by slow hydrolysis of PLA ester-bonds. Only a small population of cells was dead. Furthermore, it could be due to cells in a less active phase, such as cells entering the G0 phase, or in a maturing phase. From 6 to 12 days, the number of cell inside the PLA fabrics increased and typical fibroblastic morphology was maintained. Cells were mainly observed in the spaces between fibres. After 24 days of culture, MG-63 colonization is covering all the PLA knit. Small granular structures are present on the cell surface and low ALP concentration is detected, indicating the beginning of the differentiation process, rather than a toxic effect of PLA hydrolysis. This work shows that knitted PLA fabrics, seeded with autogeneous osteoblast cells can potentially be used as tissue-engineered implants for the treatment of bone defects. [less ▲]

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See detailThe Belgian guidelines for management of low back pain in occupational health
Mairiaux, Philippe ULg; Mazina, D. ULg

Poster (2007)

Aims As part of the promotion of a national strategy for the prevention and the management of acute and chronic low back pain (CLBP), the Belgian Health Care Knowledge Centre (KCE) funded a systematic ... [more ▼]

Aims As part of the promotion of a national strategy for the prevention and the management of acute and chronic low back pain (CLBP), the Belgian Health Care Knowledge Centre (KCE) funded a systematic review of the EBM literature concerning the management of LBP patients in the occupational health (OH) context. Taking account differences in regulations and practices within the health care system between EU countries1,2, this review aimed at issuing good practices recommendations applicable to the Belgian situation to prevent the transition from acute to chronic back pain and to avoid long duration absences from work. Methods The guidelines have been developed in three steps. First, an electronic search was performed for relevant guidelines and systematic reviews (SR) on the following databases: EMBASE, Medline, Cochrane Controlled Trials Register, NHS guidelines Finder, National Guidelines Clearing House, New Zealand Guidelines Group Search and Pedro database. The search strategy combined 3 groups of terms: low back pain, occupational medicine and the type of reference (practice guideline or SR). The identified guidelines were appraised using the AGREE method, while SR’s were appraised using the Cochrane Collaboration grid. In a second phase, the draft guidelines were submitted to a group of OH academics from the main Belgian universities. The revised version of the guidelines was then published in English in the KCE report 3. In a third step currently under way, the guidelines are adapted in a more practical format for facilitating their daily use by OH practitioners. This involves a working group of OH practitioners coming from 12 external prevention services and several large company OH services. The document will also be discussed with representatives of other health professionals (GP’s and medical advisors of the sickness funds). Results Scientific evidence from the 7 selected guidelines and from the 27 SR’s was organized according to the main missions of the occupational physician (OP) and medical adviser (MA). Which background information should be given to employers and employees when the OP is playing an adviser role? What evidence-based prevention policies (primary and secondary) should he/she promote in the enterprises? For the third mission of the OP, health surveillance of workers, the document considers three situations: periodic health surveillance, spontaneous examinations at the worker request, and return to work (RTW) examinations for workers absent for 28 days or more. The main conclusions are summarized in 4 tables under the format of key-points, each of those mentioning the quality of the evidence (using the Guyatt classification). Discussion and conclusions The key message for prevention of CLBP is the need for staying active and minimizing the time out of work. Evidence of high quality is in favor of a multidisciplinary approach using conservative treatments. One challenge is to avoid hospitalizations and especially surgery in CLBP patients. Those recommendations are relevant for all care settings, including the occupational environment. From a health care policy point of view, the project highlighted the major roles of the occupational physician and of the medical adviser and stressed the need to better define those roles if decision makers want to tackle the low back pain problem and the economic consequences of the related sick leave. References 1. Dutch Association of Occupational Medicine (NVAB). Management of low back workers by the occupational physician. Approved guidelines ; April 1999. 2. RCM-FOM. Occupational health guidelines for management of low back pain at work: Evidence Review and Recommendations. London, 2000. 3. Nielens H., Van Zundert J., Mairiaux P., Gailly J., Van Den Hecke N., Mazina D., Camberlin C., Bartholomeeussen S., De Gauquier K., Paulus D., Ramaekers D. Chronic Low Back Pain. Good Clinical Practice (GCP). Brussels: Belgian Health Care Knowledge Centre (KCE); 2006. KCE reports 48B (D/2006/10.273/64). [less ▲]

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See detailHorizontal Evaluation Method for the Implementation of the Construction Products Directive (HEMICPD)
Lor, Marc; Vause, Kevin; Dinne, Karla et al

Poster (2007)

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See detailEffects of attention on emotional face processing in depression : a functional MRI study
Desseilles, Martin; Maquet, Pierre ULg; Dang Vu, Thien Thanh et al

Poster (2007)

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See detailRole of the transcription factor HNF-6 on doublecortin expression
Degueldre, Julie; Piens, Marie; Plumier, Jean-Christophe ULg

Poster (2007)

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See detailMechanism of sound production in Oreochromis niloticus
Longrie, Nicolas; Herrel, Anthony; Mauguit, Quentin et al

Poster (2007)

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See detailLe trouble de l’attention avec hyperactivité : un trouble spécifique de l’inhibition ?
Catale, Corinne ULg; Meulemans, Thierry ULg

Poster (2007)

Unité de Neuropsychologie, Université de Liège (Belgique) Introduction Le trouble d’attention avec hyperactivité (ou ADHD, Attention Deficit/Hyperactivity Disorder) se caractérise par [1] un trouble ... [more ▼]

Unité de Neuropsychologie, Université de Liège (Belgique) Introduction Le trouble d’attention avec hyperactivité (ou ADHD, Attention Deficit/Hyperactivity Disorder) se caractérise par [1] un trouble d’attention, [2] une importante agitation motrice et [3] une impulsivité motrice. Ce trouble présente une prévalence estimée à 5 à 10% de la population prépubère, avec une nette prédominance masculine. Les conséquences de l’ADHD sont importantes : échec scolaire, difficultés d’apprentissages, mauvaise intégration sociale… En neuropsychologie, l’approche de l’ADHD vise à mieux comprendre les difficultés cognitives – et en particulier exécutives – que présentent ces enfants. Ainsi, s’il apparaît qu’un grand nombre de processus exécutifs sont altérés (voir Willcutt et al., 2005), plusieurs auteurs soulignent qu’un déficit de l’inhibition constituerait l’élément-clé qui rendrait compte des manifestations cognitives et cliniques de ce syndrome (Barkley, 1997). De nombreuses recherches ont toutefois suggéré que l’inhibition ne renvoie pas à un processus unitaire mais implique au contraire plusieurs sous-composants (inhibition verbale, motrice, perceptive ; voir par exemple Nassauer & Halperin, 2003). L’objectif de cette étude consiste à déterminer dans quelle mesure les troubles de l’inhibition présentés par les enfants ADHD sont sous-tendus par un déficit généralisé des processus inhibiteurs ou au contraire par une atteinte spécifique d’un de ces processus. Méthode Nous avons administré à 13 enfants ADHD âgé de 6 à 12 ans et 13 enfants de contrôle (appariés sur base de l’âge et du sexe) des tâches d’inhibition évaluant les capacités d’inhibition verbale (test de Stroop), motrice (épreuves de la Statue et du Go/No Go) et perceptive (Nassauer & Halperin, 2003), et une épreuve de raisonnement (Matrices de Raven Colorées). Résultats Les analyses de comparaison de moyennes indiquent que les enfants ADHD présentent des performances inférieures à celles des enfants de contrôle pour l’ensemble des épreuves d’inhibition : inhibition verbale (p<.05), motrice (p<.001) et perceptive (p<.01). Toutefois, des analyses de covariance montrent que lorsque l’on contrôle le niveau de raisonnement, les différences entre nos deux groupes disparaissent pour toutes les tâches, à l’exception de l’épreuve d’inhibition motrice « Statue ». Discussion Ces résultats préliminaires suggèrent que les enfants ADHD ne présentent pas un déficit généralisé des processus inhibiteurs, et que les troubles de l’inhibition motrice constituent probablement un élément-clé caractérisant le profil cognitif de ces enfants. Ces données confirment par ailleurs l’idée selon laquelle le concept d’inhibition recouvre des processus différents susceptibles d’être affectés de façon spécifique dans l’ADHD. [less ▲]

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See detailControlled release of drug from multicomponent device
Nizet, Dominique; Zalfen, Alina; Jérôme, Christine ULg et al

Poster (2007)

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See detailModelling spray drift using a modified air pollution Gaussian tilting plume model
Stainier, Charles; Destain, Marie-France ULg; Schiffers, Bruno ULg et al

Poster (2007)

The objective of this research is to evaluate a Gaussian tilting plume model that takes into account the spray characteristics of agricultural nozzles to predict drift. The application of this type of ... [more ▼]

The objective of this research is to evaluate a Gaussian tilting plume model that takes into account the spray characteristics of agricultural nozzles to predict drift. The application of this type of model has proved to be effective for aerial pollution applications. To be applied successfully to the spray drift, the model has to give accurate predictions of the deposits regarding the spray and material characteristics as well as the weather parameters. To reach this objective, the model parameters must be correctly set based on appropriate theoretical basis and experimental data. Based on wind tunnel measurements, the effect of the most important characteristics of spray droplets from an agricultural nozzle has been modelled using a Gaussian tilting plume approach by discretizing the different droplet classes. Although the theoretical basis of the model is simple, the predicted drift appeared to be in relatively good agreement with the experimental results. The discrepancies could be explained by poor fitting of the dispersion model parameters. Further work is required to optimise the value of the model parameters. [less ▲]

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See detailPectoral sound production in Synodontis (Mochokidae): a morphological study
Fabri, Gégory; Mauguit, Quentin; Vandewalle, Pierre ULg et al

Poster (2007)

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See detailAnalytical determination of Isomaltooligosaccharides mixture known as emerging prebiotics.
Goffin, Dorothée ULg

Poster (2007)

Isomaltooligosaccharides (IMOs) are non-digestible oligosaccharides, considered as prebiotics and therefore aim to selectively feed probiotics indigenous to the human colon. Recent data obtained in human ... [more ▼]

Isomaltooligosaccharides (IMOs) are non-digestible oligosaccharides, considered as prebiotics and therefore aim to selectively feed probiotics indigenous to the human colon. Recent data obtained in human subjects, support the involvement of dietary oligosaccharides in physiological processes in the different intestinal cell type and also outside the gastrointestinal tract (e.g. hormone production, lipid and carbohydrate metabolism). IMOs consists of glucose monomers linked by at least one α-1-6, or in a lower proportion α -1-3 (nigerose family) or α -1-2 (kojibiose family) glucosidic linkages. In our case they are produced enzymatically from corn starch. It results in a very complex mixture with molecules characterized at the same time by their DP value (from 2 to ~20), linkages types (α-1-2, 3 or 6) and the proportion and position of each type of linkage (only α -1-6 or combined types). The challenge of this study was to find a qualitative and quantitative method to characterize the syrups. In a subsequent study, every unidentified peak could be determined by NMR or Mass spectrometry. Three different chromatographic methods have been tested and compared over their selectivity, sensibility, robustness, applicability and their quantitative power. [less ▲]

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See detailThe effect of high CO2 during the first half of incubation on embryonic development after storage
Witters, A.; Debonne, M.; Everaert, Nadia ULg et al

Poster (2007)

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See detailKarsts in sandstones and quatrzites of Minas Gerais, Brazil
Willems, Luc ULg; Rodet, J.; Pouclet, A. et al

Poster (2007)

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See detailDétermination et cartographie des micro-habitats lotiques : Une approche géomorphologique
Hallot, Eric ULg; Houbrechts, Geoffrey ULg; Verniers, Gisèles et al

Poster (2007)

Lors du suivi d’aménagement ou de restauration de cours d’eau, l’analyse des micro-habitats s’avère un élément important. Leur caractérisation et leur quantification permet la comparaison avec d’autres ... [more ▼]

Lors du suivi d’aménagement ou de restauration de cours d’eau, l’analyse des micro-habitats s’avère un élément important. Leur caractérisation et leur quantification permet la comparaison avec d’autres sites témoins et de suivre leur évolution dans le temps. Une carte des micro-habitats est indispensable à la compréhension d’indices biologiques en établissant notamment une relation entre la diversification du milieu (donc des micros-habitats) et la diversité des macro-invertébrés benthiques. Cette cartographie est obtenue en croisant, grâce à un logiciel SIG, deux couches d’information, la bathymétrie et le substrat. La bathymétrie est obtenue par soustraction du MNT du fond du lit et du MNA du plan d’eau à l’étiage. Le substrat est obtenu par observation de terrain en utilisant une clé de détermination basée sur les grandes classes granulométriques du substrat et la granulométrie des éléments intercalaires. Ces deux couches d’information sont ensuite discrétisées chacune en 4 classes principales afin d’obtenir 16 types théoriques pour lesquels la superficie et la répartition peuvent être étudiés à partir d’outils SIG classiques. La méthode proposée, bien qu’aisée à mettre en œuvre, nécessite cependant une certaine expertise notamment lors de la détermination des classes du substrat. La précision du MNT du fond du lit définira quant à elle, la précision finale de la carte. Nous présentons ici deux exemples. Le premier, réalisé sur l’Ourthe Occidentale à Moircy, a permis la comparaison entre un site réaménagé et un site témoin. Le second, sur la Semois Lorraine à Sivry, a été effectué afin d’étudier l’évolution de la recolonisation par les macro- invertébrés benthiques d’un secteur réaménagé mais également de définir très précisément l’emplacement de leur échantillonnage afin d’assurer une répartition la plus représentative possible. [less ▲]

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Peer Reviewed
See detailVeszelyite: A New Blue-Green Maya Pigment
Garcia Moreno, Renata; Mathis, François ULg; Strivay, David ULg

Poster (2007)

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See detailInfluence of coral heterogenous susceptibility to warming on reef biodiversity
Ladrière, Ophélie ULg; Penin, Lucie; Adjeroud, Mehdi et al

Poster (2007)

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Peer Reviewed
See detailHigh resolution 16 row computed tomography examination of the canine thorax
De Busscher; Bolen, Géraldine ULg; Cavrenne et al

Poster (2007)

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Peer Reviewed
See detailApplying the electronic nose in the environment
Nicolas, Jacques ULg; Delva, Julien ULg; Romain, Anne-Claude ULg

Poster (2007)

The communication presents the various requirements imposed to electronic nose to become an instrument of environmental monitoring. Obstacles of the monitoring of real life environmental odours may be ... [more ▼]

The communication presents the various requirements imposed to electronic nose to become an instrument of environmental monitoring. Obstacles of the monitoring of real life environmental odours may be classified into three categories: • the final goal of the study, requiring to measure a global odour annoyance and not any gaseous emission, • the analysed sample itself, which is highly variable, due to the process evolution and to the influence of ambient parameters; • and the operating conditions, needing to work far from any building and sometimes at locations not easy to reach. The paper suggests some simple solutions to those problems. [less ▲]

Detailed reference viewed: 27 (9 ULg)