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See detailOverview on the ADONIS Project: Accurate Diagnosis of prostate cancer using Optoacoustic detection of biologically functionalized gold Nanoparticles - A new Integrated Biosensor System
Fleron, Maximilien ULg; Schol, Daureen ULg; Greisch, Jean-François et al

Poster (2007, March 21)

Overview on the ADONIS Project: Accurate Diagnosis of prostate cancer using Optoacoustic detection of biologically functionalized gold Nanoparticles - A new Integrated Biosensor System

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See detailPeculiar hydrophobic properties of the 67-78 fragment of α-synuclein are responsible for membrane destabilization and neurotoxicity
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Dupiereux-Fettweis, Ingrid ULg et al

Poster (2007, March 14)

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ... [more ▼]

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ago, tilted peptides have been detected in two other amyloidogenic proteins : the amyloid β peptide involved in Alzheimer’s disease, and the PrP protein linked to Creuztfeldt-Jakob’s disease. Tilted peptides are short protein fragments that adopt an oblique orientation when inserted into biological membranes. Tilted peptides are able to destabilize membranes. In this study, we predicted by sequence analysis and molecular modelling that the 67-78 fragment of α-synuclein is a tilted peptide. Like most of them, the α-syn 67-78 peptide is able to induce lipid mixing and leakage of unilamellar liposomes. A mutant designed by molecular modelling to decrease the destabilizing properties of the peptide was shown to be significantly less fusogenic. The neuronal toxicity was studied using human neuroblastoma cells and we demonstrated that the α-syn 67-78 peptide induces neurotoxicity. In conclusion, we have identified a tilted peptide in α-synuclein which could be involved in the toxicity induced during amyloidogenesis of α-synuclein. [less ▲]

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See detailSynthesis of functional amphiphilic copolymers for the elaboration of third generation drug nanocarriers
Alaimo, David ULg; Freichels, Hélène; Jérôme, Robert ULg et al

Poster (2007, March 08)

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See detailCoccolithophorid calcium carbonate dissolution in surface waters
Harlay, Jérôme ULg; Koch, Craig; Young, Jeremy R et al

Poster (2007, March 06)

The role of calcifying organisms in the ocean biogeochemistry has been receiving increasing attention since CO2-related global change issues such as ocean acidification were pointed out by the scientific ... [more ▼]

The role of calcifying organisms in the ocean biogeochemistry has been receiving increasing attention since CO2-related global change issues such as ocean acidification were pointed out by the scientific community. The implications of changing oceanic pH in modifying ecosystems dominated by planktonic calcifiers have been shown by mesocosm and laboratory experiments based on CO2 manipulations. The major concern of such experiments focussed on variations in the rates of ecosystem primary production and calcification due to changes in algal physiology or specific composition. Our results, from an interdisciplinary survey of coccolithophore-dominated blooms in the northern Bay of Biscay (NE Atlantic), suggest that biogenic calcite dissolution is occurring in the photic zone where surface waters are oversaturated with respect to calcite. The dissolution of CaCO3 in surface waters, evidenced by scanning electron microscopy observations, has an impact on the preservation and export of carbon in coccolithophore-dominated ecosystems and on the exchange of CO2 across the ocean-atmosphere interface. Both aspects of suspended calcite concentration reduction in natural environments (lower rates of production or dissolution) could be considered as a perturbation of the oceanic carbon cycle. We aim at presenting here a biogeochemical description of processes, including integrated primary production, calcification, and parameters such as transparent exopolymer particles concentration and particulate inorganic carbon profiles, during field studies. A mechanism for calcite dissolution, based on biological activity in microenvironments (including grazing, bacterial respiration and DMS production) is presented as a conceptual model in coccolithophore blooms. [less ▲]

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See detailCalcification and transparent exopolymer particles (TEP) production in batch cultures of Emiliania huxleyi exposed to different pCO2
De Bodt, Caroline; d'Hoop, Quentin; Harlay, Jérôme ULg et al

Poster (2007, March 06)

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP ... [more ▼]

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP accumulate until the end of the experiment and are enhanced after nutrient exhaustion. TEP contribute significantly to POC concentrations after the exponential growth phase. The very good correlation between TEP and calcite concentrations suggests that the calcification acts as a potential source of TEP in coccolithophore blooms. Finally, an Ωcalcite of 3 seems to be necessary for Ehux to calcify. [less ▲]

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See detailUse of exergy to detect and measure perturbations affecting Posidonia oceanica (L.) Delile meadows: Characterization in the sedimentary compartment
Pete, Dorothée ULg; Bouquegneau, Jean-Marie ULg; Gobert, Sylvie ULg

Poster (2007, March)

Within the scope of the European Water Framework Directive, it seems important to characterize state and evolution of marine ecosystems in a global way. So, it is proposed to use both thermodynamic ... [more ▼]

Within the scope of the European Water Framework Directive, it seems important to characterize state and evolution of marine ecosystems in a global way. So, it is proposed to use both thermodynamic indicators called exergy (Ex) and specific exergy (Exsp) in Posidonia oceanica meadows. Aims of this project are to detect and measure perturbations owed to nutrients loading and mechanical spoiling in the Mediterranean coastal zone. It will be led in the Bay of Calvi, on the microbenthic loop (organic matter, bacteria, microphytobenthos and meiofauna) and will be divided in two parts: sampling in different zone of the meadow and in situ experiments. In the end of this study, it will be possible to give a diagnostic on the health of P. oceanica meadow and to determine how this health will evolve, thanks to the introduction of the exergy in a model. [less ▲]

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See detailCarbon dioxide in European coastal waters
Borges, Alberto ULg; Schiettecatte, L.-S.; Abril, G. et al

Poster (2007, March)

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See detailBiogeochemical cycle in a coccolithophorid bloom
Suykens, Kim; Delille, Bruno ULg; Borges, Alberto ULg et al

Poster (2007, March)

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See detailA role for the transcriptional complex elongator in cell migration and spreading
Creppe, C.; Close, Pierre ULg; Cornez, I. et al

Poster (2007, March)

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See detailCO2 dynamics and related air-ice-sea gas transfer in spring pack and land fast sea ice,
Delille, Bruno ULg; Schoemann, V.; Lannuzel, D. et al

Poster (2007, March)

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See detailPolyubiquitination of the scaffold protein tank/I-traf: implications for the TLR-mediated signalling pathways
Gatot, J. S.; Gioia, R.; Chau, Tieu-Lan ULg et al

Poster (2007, March)

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See detailThe role of deformation in the bouncing droplet problem
Terwagne, Denis ULg; Gilet, Tristan ULg; Dorbolo, Stéphane ULg et al

Poster (2007, March)

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See detailPREDetector : Prokaryotic Regulatory Element Detector
Hiard, Samuel ULg; Rigali, Sébastien ULg; Colson, Séverine ULg et al

Poster (2007, February 15)

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The ... [more ▼]

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The emergence of position weight matrices based programs has facilitated the access to this approach. However, a tool that automatically estimates the reliability of the predictions and would allow users to extend predictions in genomic regions generally regarded with no regulatory functions was still highly demanded. Result: Here, we introduce PREDetector, a tool developed for predicting regulons of DNA-binding proteins in prokaryotic genomes that (i) automatically predicts, scores and positions potential binding sites and their respective target genes, (ii) includes the downstream co-regulated genes, (iii) extends the predictions to coding sequences and terminator regions, (iv) saves private matrices and allows predictions in other genomes, and (v) provides an easy way to estimate the reliability of the predictions. Conclusion: We present, with PREDetector, an accurate prokaryotic regulon prediction tool that maximally answers biologists’ requests. PREDetector can be downloaded freely at http://www.montefiore.ulg.ac.be/~hiard/predetectorfr.html [less ▲]

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, February 15)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailThe role of deformation in the bouncing droplet problem
Terwagne, Denis ULg; Gilet, Tristan ULg; Dorbolo, Stéphane ULg et al

Poster (2007, February)

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See detailFirst-Principles Study of Thermal and Elastic Properties of Al2O3
Xu, Bin ULg; Dong, Jianjun

Poster (2007, February)

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See detailProduire de la viande et du lait avec la Blanc-Bleu Belge de type mixte
Bastin, Catherine ULg; Mayeres, Patrick; Bertozzi, Carlo et al

Poster (2007, January 24)

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See detailLe "Mal-être en situation d'être seul" différencié de "l'Angoisse de séparation" : recherche sémiologique et élaboration conceptuelle
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Une recherche sémiologique sur 170 enfants a individualisé : le "mal-être en situation d'être seul". Un malaise apparaît lorsque le sujet est seul. Voici son décours développementale. Certains bébés ... [more ▼]

Une recherche sémiologique sur 170 enfants a individualisé : le "mal-être en situation d'être seul". Un malaise apparaît lorsque le sujet est seul. Voici son décours développementale. Certains bébés réclament une présence physique pour s'endormir. Vers 2,5 ans, l'enfant connaît une séparation difficile lors des premiers jours d'école. Vers 5 ans, l'enfant n'aime pas jouer seul dans une pièce sans la présence d'une autre personne ou d'un animal, et s'il le fait, il cherche à savoir en permanence où se trouve l'adulte. À l'endormissement, l'enfant appelle souvent, sort de la chambre. La nuit, il voudrait rejoindre les parents. Vers 8 ans, il n'aura pas de difficultés à quitter la maison et à se séparer de ses parents pour aller jouer avec des copains du quartier, mais il sera beaucoup plus mal à l'aise si l'un de ses parents quitte momentanément la maison. Vers 9 ans, la symptomatologie se limite à celle retrouvée chez l'adulte : un sentiment vague de mal-être à l'endormissement. L'adulte a des difficultés à mettre des mots sur ce ressenti qui est sans représentation : du "vide" ou un "rien". Il cherche à retarder la mise au lit, à s'occuper au lit pour éviter ce ressenti, et à s'endormir rapidement de fatigue. L'adulte qui ressent ce "mal-être" en journée va le contrer par 4 moyens : 1. activités 2. apport sensoriel (radios ouvertes, TV), 3. remplir son "monde interne" par la lecture 4. un animal de compagnie. Le "mal-être en situation d'être seul" : A) Est à distinguer de l'angoisse de séparation B) Est corrélé à un retard d'apparition des repères temporels, non pas séquentiels ou notionnels, mais dans l'appréhension subjective du temps : "goûter anticipativement ce que dure un certain laps de temps" C) Il serait lié à un manque d'efficience d'un support neurophysiologique permettant l'évaluation de la longueur du temps : "la jauge interne d'évaluation anticipative du temps" D) Ceci expliquerait qu'il ne suffit pas à l'enfant d'avoir des représentations pour acquérir le sentiment subjectif d'une permanence mais qu'il faut y joindre ce "feeling" du temps E) Il est systématiquement présent dans la bipolarité sans en être pathognomonique. Il se retrouve à l'état isolé et dans d'autres entités nosologiques. A minima, il est une caractéristique de la personne. [less ▲]

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See detailCleft Palate (CP): not only a diagnosis in foals
Van Galen, Gaby ULg; Delguste, Catherine ULg; Verwilghen, Denis ULg et al

Poster (2007, January)

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See detailPreconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anti-cancer therapies
Martinive, Philippe ULg

Poster (2007, January)

Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O(2) diffusion-limited hypoxia, another form of tumor hypoxia characterized by ... [more ▼]

Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O(2) diffusion-limited hypoxia, another form of tumor hypoxia characterized by fluctuating changes in pO(2) within the disorganized tumor vascular network is described. Here, we postulated that this form of intermittent hypoxia promotes endothelial cell survival, thereby extending the concept of hypoxia-driven resistance to the tumor vasculature. We found that endothelial cell exposure to cycles of hypoxia reoxygenation not only rendered them resistant to proapoptotic stresses, including serum deprivation and radiotherapy, but also increased their capacity to migrate and organize in tubes. By contrast, prolonged hypoxia failed to exert protective effects and even seemed deleterious when combined with radiotherapy. The use of hypoxia-inducible factor-1alpha (HIF-1alpha)-targeting small interfering RNA led us to document that the accumulation of HIF-1alpha during intermittent hypoxia accounted for the higher resistance of endothelial cells. We also used an in vivo approach to enforce intermittent hypoxia in tumor-bearing mice and found that it was associated with less radiation-induced apoptosis within both the vascular and the tumor cell compartments (versus normoxia or prolonged hypoxia). Radioresistance was further ascertained by an increased rate of tumor regrowth in irradiated mice preexposed to intermittent hypoxia and confirmed in vitro using distinctly radiosensitive tumor cell lines. In conclusion, we have documented that intermittent hypoxia may condition endothelial cells and tumor cells in such a way that they are more resistant to apoptosis and more prone to participate in tumor progression. Our observations also underscore the potential of drugs targeting HIF-1alpha to resensitize the tumor vasculature to anticancer treatments. PMID: 17178869 [PubMed - indexed for MEDLINE] [less ▲]

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See detailL'utilité de l'association aripiprazole-méthylphénidate en pédopsychiatrie, selon les diagnostics
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Introduction : En pédopsychiatrie, les enfants présentent souvent des comorbidités. L'AD et/ou HD peut être associée à tous les diagnostics de la nosographie. Une diversité de diagnostics répond aux ... [more ▼]

Introduction : En pédopsychiatrie, les enfants présentent souvent des comorbidités. L'AD et/ou HD peut être associée à tous les diagnostics de la nosographie. Une diversité de diagnostics répond aux antipsychotiques atypiques et l'ADHD répond au méthylphénidate. Par contre, il n'existe aucune étude qui analyse l'effet simultané d'aripiprazole-méthylphénidate chez l'enfant. Objectifs : Établir le diagnostic des comorbidités chez les enfants et évaluer dans un suivi de cohorte : l'efficacité de l'association aripiprazole-méthylphénidate, les posologies et les effets secondaires. Méthode : Établissement des diagnostics des comorbidités chez 31 enfants, 22 garçons et 9 filles, de 5 à 12 ans (moy: 9,1 ans), suivis dans 2 Services de Santé Mentale. Les diagnostics sont établis selon: le DSM IV et les critères des Troubles de la Régulation des stimuli sensoriels de la « Classification des Diagnostics des Troubles de la Santé Mentale et du Développement de la Petite Enfance, DC:0-3R », 2005. Les posologies et effets secondaires sont évalués dans un suivi longitudinal de 8 mois en moy/enfant. Résultats : Comorbidités : ADHD (31) [AD (4), HD (2), mixte (25)], états paranoïdes (11), autres projections psychotiques (10), symptômes négatifs (10), bipolarité (25) [maniaque (10), mixte (13), dépressif (2)], colères en "on-off" (18), troubles de la régulation (17), autisme (2), somnambulisme (1). Aripiprazole-méthylphénidate est efficace dans l'ensemble de ces diagnostics. L'aripiprazole est efficace dans les Troubles de la Régulation ; ceci est une nouvelle indication thérapeutique. Posologie. Aripiprazole : 1,0 mg/10 kilos (min 0,8 et max 1,8 mg), 1 prise/j. Méthylphénidate : 7 mg/10 kilos/j (min 5 et max 10 mg). Arrêt de l'aripiprazole : 2 arrêts pour accroissement de l'agressivité, 1 arrêt pour augmentation de la sensibilité des perceptions avec peurs. Arrêt du méthylphénidate : 1 arrêt pour coliques abdominales. Arrêt du méthylphénidate et de l'aripiprazole : aripiprazole suite à une somnolence importante non dose dépendante et méthylphénidate suite à un accroissement de l'excitabilité non dose dépendante chez 1 enfant. Conclusion : L'association aripiprazole-méthylphénidate est très bien tolérée, avec un bénéfice additif lorsque l'enfant présente en comorbidité un AD et/ou HD (26). [less ▲]

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See detailL’aripiprazole chez les enfants de 5 à 12 ans : étude clinique. Indications, intérêt, posologie, effets secondaires
Scholl, Jean-Marc ULg; Philippe., Paule ULg

Poster (2007, January)

Introduction : Les antipsychotiques atypiques ont de tout autres propriétés que les neuroleptiques. Leurs indications comprennent de nombreux diagnostics "non psychotiques". Ils sont largement utilisés ... [more ▼]

Introduction : Les antipsychotiques atypiques ont de tout autres propriétés que les neuroleptiques. Leurs indications comprennent de nombreux diagnostics "non psychotiques". Ils sont largement utilisés chez les enfants. L'aripiprazole est le dernier venu des antipsychotiques atypiques et il est le premier agoniste partiel dopaminergique et sérotoninergique. Il a des propriétés originales dont les effets sont peu connus chez les enfants. Objectifs : Évaluer l'efficacité de l'aripiprazole selon les diagnostics, les posologies utiles et les effets secondaires dans un suivi de cohorte. Méthode : Étude transversale descriptive de 37 enfants, 25 garçons et 12 filles, âgés de 5 à 12 ans (moy: 8 ans 7 mois), suivis dans 2 Services de Santé Mentale. Les diagnostics sont établis selon: 1. le DSM IV et 2. les critères des Troubles de la Régulation des stimuli sensoriels de la « Classification des Diagnostics des Troubles de la Santé Mentale et du Développement de la Petite Enfance, (DC:0-3R, 2005) ». Une attention particulière est portée au diagnostic des comorbidités. Les posologies et effets secondaires sont évalués dans un suivi longitudinal de 8 mois en moy. par enfant. Résultats : L'aripiprazole est efficace dans les : états paranoïdes (14), autres projections psychotiques (10), symptômes négatifs (12), la bipolarité (25), les colères en "on-off" (18), les troubles de la régulation (21), l'autisme (3), le somnambulisme (2). Posologie thérapeutique : 1,0 mg/10 kilos (min. 0,8 et max 1,8 mg), 1 prise/j. Effets secondaires : nausées entre le Ier et le 10e jour (6), somnolence importante (2), augmentation de la sensibilité des perceptions durant les 4 premières semaines de traitement (4), accroissement de l'agressivité avec sentiments de persécution (2), épisodes de palpitations avec tachycardie (2). Arrêt du traitement : 2 arrêts pour somnolence importante non dose-dépendante (une enfant a une immaturité neurologique et l'autre une leucomalacie périventriculaire avec épilepsie), 2 autres arrêts pour accroissement de l'agressivité, et un 5e arrêt suite à des palpitations et tachycardie (examens cardiologiques normaux). L'association aripiprazole-méthylphénidate est très bien tolérée et apporte un bénéfice additif lorsque l'enfant présente en comorbidité un AD et/ou HD (26). [less ▲]

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See detailMiroir interne déformant de l'image de soi : élaboration conceptuelle intégrant la clinique et les découvertes récentes des neurosciences
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est ... [more ▼]

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est différent de celui qui permet au sujet de donner des attributs à d'autres individus. Le réseau référé au self permet d'être en contact immédiat avec l'image et la connaissance de soi. De plus, le rappel mnésique des attributs positifs et négatifs référés au self met en jeu des réseaux neuronaux différents. Les attributs positifs référés au self activent la région préfrontale antéromédiane droite, les attributs négatifs référés au self la région préfrontale dorsolatérale droite. Le sujet sain active les deux réseaux de façon simultanée pour restituer une image de soi intégrée. Définition conceptuelle: Le "miroir interne" – distingué de l'objet qui lui est présenté – correspond¬ au réseau neuronal référé spécifiquement au self. Ce réseau accède à l'image de soi. S'il y a un dysfonctionnement du réseau référé au self, il restitue une image déformée de soi, et le "miroir interne" devient déformant. Le sujet associera son identité à cette image déformée. Clinique du «miroir interne déformant de l'image de soi» : Le regard de l'enfant sur lui-même lui renvoie une image plus négative que ce que ses interlocuteurs ne perçoivent de lui. Dès le départ, l'enfant a une mauvaise perception de lui-même. Lorsqu'un interlocuteur lui fait une remarque, l'enfant bascule dans une image déformée et bien plus négative que celle que ne lui prête l'interlocuteur. Un dysfonctionnement de ces réseaux déséquilibre la balance et ne fait apparaître "qu'une seule couleur" dans le "miroir interne" par une restitution mnésique univoque : ou des attributs positifs, ou des attributs négatifs. Une prépondérance de l'image négative évoque un terrain dépressif, des personnalités évitante ou dépendante. Une prépondérance de l'image positive évoque des personnalités narcissiques, une image mégalomaniaque. Un dysfonctionnement neuronal peut induire une labilité et une instabilité de cette image (borderline), ou, une bascule rapide en "on-off" d'images positives et négatives de soi (rencontrée en pédopsychiatrie). Une psychoéducation permet la prise de conscience de ce miroir interne déformant. [less ▲]

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See detailUltrasonography and histology of equine menisci; a comparative study of the medial
De Busscher,V; Gabriel, Annick ULg; Cassart, Dominique ULg et al

Poster (2007, January)

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See detailInfluence of coral heterogenous susceptibility to warming on reef biodiversity
Ladrière, Ophélie ULg; Penin, Lucie; Adjeroud, Mehdi et al

Poster (2007)

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See detailSound production by pectoral spines in Six Synodontis species (Mochokidae)
Fabri, Grégory; Mauguit, Quentin; Vandewalle, Pierre ULg et al

Poster (2007)

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See detailLe trouble de l’attention avec hyperactivité : un trouble spécifique de l’inhibition ?
Catale, Corinne ULg; Meulemans, Thierry ULg

Poster (2007)

Unité de Neuropsychologie, Université de Liège (Belgique) Introduction Le trouble d’attention avec hyperactivité (ou ADHD, Attention Deficit/Hyperactivity Disorder) se caractérise par [1] un trouble ... [more ▼]

Unité de Neuropsychologie, Université de Liège (Belgique) Introduction Le trouble d’attention avec hyperactivité (ou ADHD, Attention Deficit/Hyperactivity Disorder) se caractérise par [1] un trouble d’attention, [2] une importante agitation motrice et [3] une impulsivité motrice. Ce trouble présente une prévalence estimée à 5 à 10% de la population prépubère, avec une nette prédominance masculine. Les conséquences de l’ADHD sont importantes : échec scolaire, difficultés d’apprentissages, mauvaise intégration sociale… En neuropsychologie, l’approche de l’ADHD vise à mieux comprendre les difficultés cognitives – et en particulier exécutives – que présentent ces enfants. Ainsi, s’il apparaît qu’un grand nombre de processus exécutifs sont altérés (voir Willcutt et al., 2005), plusieurs auteurs soulignent qu’un déficit de l’inhibition constituerait l’élément-clé qui rendrait compte des manifestations cognitives et cliniques de ce syndrome (Barkley, 1997). De nombreuses recherches ont toutefois suggéré que l’inhibition ne renvoie pas à un processus unitaire mais implique au contraire plusieurs sous-composants (inhibition verbale, motrice, perceptive ; voir par exemple Nassauer & Halperin, 2003). L’objectif de cette étude consiste à déterminer dans quelle mesure les troubles de l’inhibition présentés par les enfants ADHD sont sous-tendus par un déficit généralisé des processus inhibiteurs ou au contraire par une atteinte spécifique d’un de ces processus. Méthode Nous avons administré à 13 enfants ADHD âgé de 6 à 12 ans et 13 enfants de contrôle (appariés sur base de l’âge et du sexe) des tâches d’inhibition évaluant les capacités d’inhibition verbale (test de Stroop), motrice (épreuves de la Statue et du Go/No Go) et perceptive (Nassauer & Halperin, 2003), et une épreuve de raisonnement (Matrices de Raven Colorées). Résultats Les analyses de comparaison de moyennes indiquent que les enfants ADHD présentent des performances inférieures à celles des enfants de contrôle pour l’ensemble des épreuves d’inhibition : inhibition verbale (p<.05), motrice (p<.001) et perceptive (p<.01). Toutefois, des analyses de covariance montrent que lorsque l’on contrôle le niveau de raisonnement, les différences entre nos deux groupes disparaissent pour toutes les tâches, à l’exception de l’épreuve d’inhibition motrice « Statue ». Discussion Ces résultats préliminaires suggèrent que les enfants ADHD ne présentent pas un déficit généralisé des processus inhibiteurs, et que les troubles de l’inhibition motrice constituent probablement un élément-clé caractérisant le profil cognitif de ces enfants. Ces données confirment par ailleurs l’idée selon laquelle le concept d’inhibition recouvre des processus différents susceptibles d’être affectés de façon spécifique dans l’ADHD. [less ▲]

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See detailPhotodegradation of bacteria with TiO2 produced by sol-gel method
Tasseroul, Ludivine ULg; Pàez Martinez, Carlos ULg; Braconnier, Benoît et al

Poster (2007)

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See detailThe Dusty Young Universe: photometry and spectroscopy of quasars at z > 2
Meisenheimer, K.; Hutsemekers, Damien ULg; Tacconi, L. et al

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See detailThe lymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2007)

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See detailCaractérisation de la protéine 9p du virus de la varicelle et du zona (VZV)
Joris-Gerards, Aline; BONTEMS, Sébastien ULg; Di Valentin et al

Poster (2007)

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See detailEffects of attention on emotional face processing in depression : a functional MRI study
Desseilles, Martin; Maquet, Pierre ULg; Dang Vu, Thien Thanh et al

Poster (2007)

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See detailThe effect of high CO2 during the first half of incubation on embryonic development after storage
Witters, A.; Debonne, M.; Everaert, Nadia ULg et al

Poster (2007)

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See detailSTAT5 is an Ambivalent Regulator of Neutrophil Homeostasis
Fievez, Laurence ULg; Desmet, Christophe ULg; Henry, E. et al

Poster (2007)

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See detailVascular architecture of breast cancer xenographs over-expressing MT4-MMP
Chabottaux, V; Thiry, Marc ULg; Alvarez Gonzalez, M-L et al

Poster (2007)

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See detailThe Mus musculus Mx1 gene confers strong protection against highly pathogenic influenzavirus A H5N1
Garigliany, Mutien-Marie ULg; Lambrecht, Bénédicte; Leroy, Michaël et al

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See detailThe Belgian guidelines for management of low back pain in occupational health
Mairiaux, Philippe ULg; Mazina, D. ULg

Poster (2007)

Aims As part of the promotion of a national strategy for the prevention and the management of acute and chronic low back pain (CLBP), the Belgian Health Care Knowledge Centre (KCE) funded a systematic ... [more ▼]

Aims As part of the promotion of a national strategy for the prevention and the management of acute and chronic low back pain (CLBP), the Belgian Health Care Knowledge Centre (KCE) funded a systematic review of the EBM literature concerning the management of LBP patients in the occupational health (OH) context. Taking account differences in regulations and practices within the health care system between EU countries1,2, this review aimed at issuing good practices recommendations applicable to the Belgian situation to prevent the transition from acute to chronic back pain and to avoid long duration absences from work. Methods The guidelines have been developed in three steps. First, an electronic search was performed for relevant guidelines and systematic reviews (SR) on the following databases: EMBASE, Medline, Cochrane Controlled Trials Register, NHS guidelines Finder, National Guidelines Clearing House, New Zealand Guidelines Group Search and Pedro database. The search strategy combined 3 groups of terms: low back pain, occupational medicine and the type of reference (practice guideline or SR). The identified guidelines were appraised using the AGREE method, while SR’s were appraised using the Cochrane Collaboration grid. In a second phase, the draft guidelines were submitted to a group of OH academics from the main Belgian universities. The revised version of the guidelines was then published in English in the KCE report 3. In a third step currently under way, the guidelines are adapted in a more practical format for facilitating their daily use by OH practitioners. This involves a working group of OH practitioners coming from 12 external prevention services and several large company OH services. The document will also be discussed with representatives of other health professionals (GP’s and medical advisors of the sickness funds). Results Scientific evidence from the 7 selected guidelines and from the 27 SR’s was organized according to the main missions of the occupational physician (OP) and medical adviser (MA). Which background information should be given to employers and employees when the OP is playing an adviser role? What evidence-based prevention policies (primary and secondary) should he/she promote in the enterprises? For the third mission of the OP, health surveillance of workers, the document considers three situations: periodic health surveillance, spontaneous examinations at the worker request, and return to work (RTW) examinations for workers absent for 28 days or more. The main conclusions are summarized in 4 tables under the format of key-points, each of those mentioning the quality of the evidence (using the Guyatt classification). Discussion and conclusions The key message for prevention of CLBP is the need for staying active and minimizing the time out of work. Evidence of high quality is in favor of a multidisciplinary approach using conservative treatments. One challenge is to avoid hospitalizations and especially surgery in CLBP patients. Those recommendations are relevant for all care settings, including the occupational environment. From a health care policy point of view, the project highlighted the major roles of the occupational physician and of the medical adviser and stressed the need to better define those roles if decision makers want to tackle the low back pain problem and the economic consequences of the related sick leave. References 1. Dutch Association of Occupational Medicine (NVAB). Management of low back workers by the occupational physician. Approved guidelines ; April 1999. 2. RCM-FOM. Occupational health guidelines for management of low back pain at work: Evidence Review and Recommendations. London, 2000. 3. Nielens H., Van Zundert J., Mairiaux P., Gailly J., Van Den Hecke N., Mazina D., Camberlin C., Bartholomeeussen S., De Gauquier K., Paulus D., Ramaekers D. Chronic Low Back Pain. Good Clinical Practice (GCP). Brussels: Belgian Health Care Knowledge Centre (KCE); 2006. KCE reports 48B (D/2006/10.273/64). [less ▲]

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See detailEffect of base mutations in GC rich binding site on recognition by minor groove binding dications
Munde, M; Ismail, M; Peixoto, Paul ULg et al

Poster (2007)

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See detailAdenosine thiamine triphosphate, a new signal synthesized in response to specific forms of cellular stress in Escherichia coli
Gigliobianco, Tiziana ULg

Poster (2007)

Thiamine, also known as vitamin B1, and its different phosphorylated derivates are found in all known organisms. The main form of the vitamin is the coenzyme thiamine diphosphate (ThDP). Thiamine ... [more ▼]

Thiamine, also known as vitamin B1, and its different phosphorylated derivates are found in all known organisms. The main form of the vitamin is the coenzyme thiamine diphosphate (ThDP). Thiamine triphosphate (ThTP) is also found in low amounts in all organisms studied from bacteria to mammals. In E. coli ThTP accumulation is linked to amino acid starvation and the presence of a suitable carbon source. Recently a new thiamine derivative, adenosine thiamine triphosphate (AThTP) or thiaminylated ATP was discovered in our laboratory. AThTP is accumulated in E. coli during carbon starvation. When the cells are grown under optimal conditions (rich medium containing amino acids) neither ThTP nor AThTP is present in significant amounts. The synthesis of both compounds is inhibited by amino acids. In E. coli, AThTP accumulates in response to two different conditions of metabolic stress: lack of energy substrates (or inhibition of their metabolization) and uncoupled pyruvate oxidation. [less ▲]

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See detailDisseminated Penicillium marneffei infection contrated in China
Hayette, Marie-Pierre ULg; Mukeba Tschialala, Didier; Meex, Cécile ULg et al

Poster (2007)

Penicillium marneffei infection is a rare fungal disease that cause significant disease in immunosuppressed patients. The geographical distribution of this dimorphic fungus is restricted to Asia ... [more ▼]

Penicillium marneffei infection is a rare fungal disease that cause significant disease in immunosuppressed patients. The geographical distribution of this dimorphic fungus is restricted to Asia, Southeast and Far East, where the disease is considered as an indicator of acquired immunodeficiency syndrome (AIDS). Case report. A 42-year old Congolese woman living in Lubumbashi was admitted at the university hospital of Liège for exploration of a general status impairment. She experienced for three months spiking fever, weight loss, productive cough with bloody expectorations and progressive dyspnoea. She reported also to have non-bloody mild diarrhoea with abdominal pain. The HIV antibody status was positive with a low CD4 T lymphocytes count (28/µl). Pulmonary infiltrates were visualized on chest radiography and the computed tomography revealed the presence of a severe pneumopathy characterised by bilateral micronodular lesions. Mediastinal polyadenopathies associated with hepato- and splenomegaly were also highlighted. Bronchoscopy was performed and bronchial aspirations revealed the presence of numerous leucocytes with the presence of intracellular Gram positive organisms suggestive of yeasts. Ziehl, Giemsa and Gomori-Grocott staining were also performed. Ziehl staining was negative. The morphological aspect given by Giemsa staining excluded infection and the PCR specific for T. gondii B1 gene was negative. However, Gomori-Grocott staining revealed the presence of intracellular oval, elongated, sausage-shaped cells with a single transverse septum (3 to 5 µm). Penicillium marneffei was isolated from blood culture and respiratory samples. Intraveinous amphotericin B treatment was administrated during 15 days followed by itraconazole oral administration (200 mg/j). The antimycotic treatment improved the patient condition and despite other clinical troubles she was prematurely discharged because of financial problems. Conclusion. Opportunistic agents involved in HIV-infected patients differ in Africa and Asia and it is important to be able to make a rapid diagnosis with the aid of an experienced laboratory. [less ▲]

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See detailComputed tomography anatomy of the equine metacarpo-phalangeal joint
Vanderperren; Ghaye, Benoit ULg; Hoegaerts, Michel et al

Poster (2007)

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See detailLast two Millennia atmospheric lead and heavy metals inputs in a Belgian peat bog: regional to global Human impacts
De Vleeschouwer; Gerard; Goormaghtigh et al

Poster (2007)

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See detailEvaluation of the antitumor activity of 16K prolactin
Kinet, Virginie; Nguyen, Ngoc-Quynh-Nhu ULg; Cornet, Anne ULg et al

Poster (2007)

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See detailCarbon dioxide in European coastal waters
Borges, Alberto ULg; Schiettecatte, L.-S.; Abril, G. et al

Poster (2007)

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See detailCaractériser un profil inflammatoire grâce à l'utilisation du microdamier
Ramery, Eve ULg; Closset, Rodrigue; Bureau, Fabrice ULg et al

Poster (2007)

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See detailPectoral sound production in Synodontis (Mochokidae): a morphological study
Fabri, Gégory; Mauguit, Quentin; Vandewalle, Pierre ULg et al

Poster (2007)

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See detailSIZE DISTRIBUTION OF METALLIC POWDERS : A COMPARISON OF DIGITAL IMAGING AND LASER DIFFRACTION
Gregoire, Max; Michel, Frédéric ULg; Campana, Florent et al

Poster (2007)

Automated image analysis of particles under controlled orientation (SIA) is becoming a challenging technique for laser diffraction (LD) in the field of sizing metallic particles above 5 μm. Thanks to ... [more ▼]

Automated image analysis of particles under controlled orientation (SIA) is becoming a challenging technique for laser diffraction (LD) in the field of sizing metallic particles above 5 μm. Thanks to optimal particle dispersion and fully automated microscopic imaging, it is now possible to gather individual measurements on thousands of particles within a minute. The aim of this paper is to compare results obtained with both image analysis and laser diffraction from a selection of powders (figure 1) in the range between 5 μm and 250 μm. [less ▲]

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See detailMG-63 Osteoblast culture on P culture on PLA– based copolymers for bone tissue engineering applications
Moniotte, Nicolas; Shim, Yong-Ho; Borget, Pascal et al

Poster (2007)

Physical injury or pathological changes such as removal of a tumor can result in large bone defects, preventing the recovery of its original function. Autogenous bone grafting, which is the most common ... [more ▼]

Physical injury or pathological changes such as removal of a tumor can result in large bone defects, preventing the recovery of its original function. Autogenous bone grafting, which is the most common technique for bone defect repairing, is associated with serious limitations, e.g. limited supply and donor site morbidity. Since a few years bone tissue engineering by degradable biomaterials has been shown as a very promising avenue for providing bone substitutes. Among these materials, bioresorbable synthetic polymers such as poly(ethylene oxide) (PEO), poly(vinyl alcohol) (PVA), poly(acrylic acid) (PAA) and poly(lactic acid) (PLA) are very appealing because their chemistry and properties are controllable and reproducible. Cellular activity and proliferation of osteosarcoma cell lines (MG-63) on films were determined by the tetrazolium salt MTT assay and by phase contrast/fluorescence microscope observations. The cytotoxicity of the materials was found to be low or negligible. Cells viability variations were observed on the surface of the films. Long-term cell culture and degradability of PLA-PEOpolymer film was investigated by optical microscopy (Giemsa staining) and environmental scanning electron microscopy (ESEM). Hydrolysis of the PLLA ester linkages led to slow film degradation. After 113 days, optical microscope observations revealed the presence of large cracks on the surface, and even breaks of small polymer fragments, while MG-63 proliferation was still very important, showing a tissue-like aspect, with extracellular matrix (ECM) deposition. These results show that PLA-PEO copolymers are very interesting bioresorbable materials for long-term bone tissue engineering applications. [less ▲]

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See detailComparison of different techniques for inoculation of Candidatus phytoplasma mali in biological indexing
Aldaghi, M.; Massart, Sébastien ULg; Roussel, S. et al

Poster (2007)

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See detailAnalytical determination of Isomaltooligosaccharides mixture known as emerging prebiotics.
Goffin, Dorothée ULg

Poster (2007)

Isomaltooligosaccharides (IMOs) are non-digestible oligosaccharides, considered as prebiotics and therefore aim to selectively feed probiotics indigenous to the human colon. Recent data obtained in human ... [more ▼]

Isomaltooligosaccharides (IMOs) are non-digestible oligosaccharides, considered as prebiotics and therefore aim to selectively feed probiotics indigenous to the human colon. Recent data obtained in human subjects, support the involvement of dietary oligosaccharides in physiological processes in the different intestinal cell type and also outside the gastrointestinal tract (e.g. hormone production, lipid and carbohydrate metabolism). IMOs consists of glucose monomers linked by at least one α-1-6, or in a lower proportion α -1-3 (nigerose family) or α -1-2 (kojibiose family) glucosidic linkages. In our case they are produced enzymatically from corn starch. It results in a very complex mixture with molecules characterized at the same time by their DP value (from 2 to ~20), linkages types (α-1-2, 3 or 6) and the proportion and position of each type of linkage (only α -1-6 or combined types). The challenge of this study was to find a qualitative and quantitative method to characterize the syrups. In a subsequent study, every unidentified peak could be determined by NMR or Mass spectrometry. Three different chromatographic methods have been tested and compared over their selectivity, sensibility, robustness, applicability and their quantitative power. [less ▲]

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See detailVascular architecture of breast cancer xenographs over-expressing MT4-MMP
Chabottaux, V; Thiry, Marc ULg; Blacher, Silvia ULg et al

Poster (2007)

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See detailPlant-based production of human lysozyme mutants
Tocquin, Pierre ULg; Dumoulin, Mireille ULg; Dony, Nicolas ULg et al

Poster (2007)

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