References of "Poster"
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See detailSchizophrénie et psychopathie : Analyse des difficultés d’objectivation diagnostique à partir de la PCL-R
Matteucci, Marie; Englebert, Jérôme ULiege; De Page, Louis et al

Poster (2017, May 20)

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See detailL’impact de la réserve cognitive sur le fonctionnement exécutif au cours du vieillissement normal
Lesoinne, Alexia ULiege; Simon, Jessica ULiege; Gilsoul, Jessica ULiege et al

Poster (2017, May 20)

Il existe une forte variabilité interindividuelle quant aux effets du vieillissement sur la cognition. Selon Stern (2009), les individus qui ont développé un haut niveau de réserve cognitive résisteraient ... [more ▼]

Il existe une forte variabilité interindividuelle quant aux effets du vieillissement sur la cognition. Selon Stern (2009), les individus qui ont développé un haut niveau de réserve cognitive résisteraient mieux aux effets du vieillissement. Afin de déterminer les facteurs de réserve cognitive qui expliquent le déclin exécutif dans le vieillissement, nous avons recruté 165 participants âgés de 59 à 81 ans. Ils ont effectué sept tâches évaluant le fonctionnement exécutif : des épreuves d’inhibition (Stroop et Incompatibilité de la TAP), de flexibilité (Flexibilité de la TAP, épreuve d’alternance arithmétique « plus-moins ») et de mise à jour (subtest Lettre-Chiffre de la MEM III, mise à jour de consonnes et tâche de 2-back). De plus, les participants ont complété différents questionnaires évaluant quatre facteurs de réserve cognitive (niveau d’études, parcours professionnel, activité physique et activités de loisir). Nous avons réalisé des analyses de régression linaire hiérarchique. Après avoir contrôlé les facteurs démographiques, nous avons observé que la réalisation d’au moins une activité culturelle au cours de la vie impactait positivement les capacités d’inhibition, alors que la mise à jour était impactée négativement par un trop grand nombre de loisirs domestiques. Lorsqu’on considère les loisirs actuellement pratiqués, nous observons que la réalisation d’au moins un loisir social a un impact positif sur la flexibilité alors que deux activités à caractère social sont nécessaires pour avoir un impact positif sur la mise à jour. En conclusion, nous observons un effet mitigé et différencié de la réserve cognitive sur le déclin exécutif. [less ▲]

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See detailLa modalité est importante quand on mène un jugement de reconnaissance basées sur la fluence, mais les patients atteints d’amnésie ne s’en soucient pas
Thonnard, Adeline; Geurten, Marie ULiege; Willems, Sylvie ULiege

Poster (2017, May 20)

La reconnaissance chez les patients amnésiques repose principalement sur le sentiment de familiarité. Plusieurs études indiquent que ce sentiment de familiarité pourrait reposer sur la facilité de ... [more ▼]

La reconnaissance chez les patients amnésiques repose principalement sur le sentiment de familiarité. Plusieurs études indiquent que ce sentiment de familiarité pourrait reposer sur la facilité de traitement. Cependant, si les patients amnésiques utilisent normalement cette heuristique métacognitive est une question qui n’a pas encore été explorée de manière approfondie. Dans la présente étude, nous avons utilisé le paradigme de l'illusion de Jacoby et Whitehouse (1989) avec 8 patients atteints de troubles graves de la mémoire et 16 participants sains et appariés. La facilité de traitement a été induite lors du test de reconnaissance en présentant brièvement une amorce qui correspondait au mot devant être évalué. Les résultats préliminaires de cette étude ont révélé que la facilité de traitement induite par l’amorce augmentait les réponses de reconnaissance lorsque la phase d'étude et la phase de test étaient dans la même modalité sensorielle, mais non lorsque l'étude et le test étaient dans des modalités différentes. Les sujets sont donc capables de moduler leur utilisation de la facilité de traitement en tant qu’indice de mémoire en fonction de la non-diagnosticité perçue de cet indice. Cependant, cet effet de modalité semble limité aux participants sains. Les patients amnésiques quant à eux ne semble pas moduler leur utilisation de l'heuristique de fluence. Dans l'ensemble, ces résultats suggèrent que la facilité de traitement peut être utilisée comme un indice pour la reconnaissance dans l'amnésie. Cependant, cette utilisation est sujette à des changements métacognitifs. [less ▲]

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See detailLa nature des intérêts spécifiques distingue les personnes avec et sans retard de langage.
Chiodo, Liliane ULiege; Majerus, Steve ULiege; Eusèbe, Sandrine et al

Poster (2017, May 20)

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See detailLe fonctionnement exécutif dans le vieillissement normal : l’effet médiateur de la vitesse de traitement et du système attentionnel
Gilsoul, Jessica ULiege; Simon, Jessica ULiege; Collette, Fabienne ULiege

Poster (2017, May 19)

Introduction. Le vieillissement normal est associé à une diminution d’efficacité des fonctions exécutives. Cependant, la source de ces difficultés pourrait résider dans certains facteurs « non exécutifs » ... [more ▼]

Introduction. Le vieillissement normal est associé à une diminution d’efficacité des fonctions exécutives. Cependant, la source de ces difficultés pourrait résider dans certains facteurs « non exécutifs ». Dès lors, cette étude a pour but de déterminer si la vitesse de traitement et les variables attentionnelles pourraient médier l’effet de l’âge sur le fonctionnement exécutif. Méthode. Des participants jeunes (N = 104) et âgés (N = 63) ont réalisé une batterie de 21 tâches exécutives (inhibition, flexibilité, mise à jour, et coordination de double tâches), attentionnelles (alerte phasique, attention sélective, et attention soutenue), et de vitesse de traitement. Des modèles de médiation avec la vitesse de traitement et le fonctionnement attentionnel pris séparément comme médiateurs ont été réalisés. Résultats. L’attention sélective médie significativement l’effet de l’âge sur la mise à jour [ΔR2 = 7%, p < ,001]. De plus, la vitesse de traitement médie significativement l’effet de l’âge sur la flexibilité [ΔR2 = 7%, p < ,001], la mise à jour [ΔR2 = 5%, p < ,001], et la coordination de double tâches [ΔR2 = 14%, p < ,001].Discussion. La médiation de l’effet de l’âge sur la plupart des fonctions exécutives par les mesures de vitesse est en accord avec la littérature montrant une grande influence d’un ralentissement de la vitesse de traitement sur la cognition. L’effet de l’âge sur l’inhibition ne semble médié par aucune des variables attentionnelles et de vitesse, ce qui est en accord avec l’hypothèse selon laquelle l’inhibition serait la première fonction cognitive à décliner avec l’avancée en âge (Zacks & Hasher,1988). [less ▲]

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See detailViolence psychologique dans les relations amoureuses – Quelle tolérance à la perpétration et à la victimisation ?
Courtain, Audrey ULiege; Glowacz, Fabienne ULiege

Poster (2017, May 19)

Les relations amoureuses des jeunes adultes peuvent être empreintes de diverses formes de violences (psychologique, physique ou sexuelle). La recherche considère généralement que la violence psychologique ... [more ▼]

Les relations amoureuses des jeunes adultes peuvent être empreintes de diverses formes de violences (psychologique, physique ou sexuelle). La recherche considère généralement que la violence psychologique est moins grave que les formes physique ou sexuelle. Or, elle ne peut pas être négligée. Notre objectif de faire un état des lieux des violences psychologiques que ces jeunes peuvent agir ou subir dans leurs relations amoureuses, et d’explorer dans quelle mesure ils ont des attitudes qui tolèrent (ou pas) ces violences. Méthodologie : Un questionnaire papier a été administré à un large échantillon composé d’étudiants (N>1000, 18-25 ans) en Belgique francophone. Ce questionnaire reprend deux outils : l’un traitant de la violence dans les relations amoureuses (« Conflict in Adolescent Dating Relationships Inventory », Wolfe et al., 2001) et l’autre traitant des attitudes relatives à ces violences («Attitudes Toward Dating Violence Scale », Price & Byers, 1999). Résultats : Après un descriptif des prévalences de violences psychologiques agies et subies, ainsi que des attitudes des participants, nous traiterons des liens entre les violences psychologiques et les attitudes afférentes, en termes de perpétration et de victimisation. Tout au long de nos analyses, les différences de genre seront considérées. Discussion : Ces résultats nous montrent comment les violences psychologiques et leurs attitudes afférentes sont liés, tant en termes de perpétration que de victimisation. S’inscrivant dans la continuité des recherches américaines, nos résultats encouragent l’élaboration de programmes de prévention et de sensibilisation auprès des jeunes adultes par un travail sur les attitudes. [less ▲]

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See detailMechanochemical Unfolding of Artificial Helical Foldamers
Devaux, Floriane ULiege; Li, Xuesong; Ivan, Huc et al

Poster (2017, May 19)

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See detailExploration des processus de recollection et de familiarité chez des patients présentant une plainte mnésique : une étude longitudinale
Simon, Jessica ULiege; Collette, Fabienne ULiege; SALMON, Eric ULiege et al

Poster (2017, May 19)

Recollection refers to recall of details about past events, and familiarity is a feeling of oldness. In this study, we tested how recollection and familiarity are affected in patients with memory ... [more ▼]

Recollection refers to recall of details about past events, and familiarity is a feeling of oldness. In this study, we tested how recollection and familiarity are affected in patients with memory complaints compared to normal aging. We recruited 23 healthy older participants, 9 patients with subjective memory impairment (SCI) and 23 patients with mild cognitive impairment (MCI). Participants performed one 2-alternative forced-choice and one Yes-No recognition memory task including pictures and words, followed by a short neuropsychological evaluation. Fifteen healthy participants and 23 patients (9 SCI and 14 MCI) took part in a neuropsychological follow-up after a mean delay of 21 months. At inclusion, MCI patients had poorer performance in recognition than the other groups, which did not differ. MCI patients had worse performance regarding familiarity and recollection indexes compared to healthy controls and SCI, who exhibit similar performance. There was no interaction between groups and format or material. During the follow-up evaluation, five MCI returned to a normal level of efficiency and were considered as SCI. Based on the French adaptation of the free and cued selective reminding test (RLRI-16), we calculated cognitive decline curves in our patients. We observed that recollection and familiarity indexes were explained by the decline curves calculated on the number of freely recalled items. So, recollection and familiarity were used less efficiently in MCI than SCI although both groups complained about their memory. [less ▲]

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See detailRecollection versus familiarité dans le vieillissement normal et pathologique : Impact du format du test
Simon, Jessica ULiege; Gilsoul, Jessica ULiege; SALMON, Eric ULiege et al

Poster (2017, May 19)

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to ... [more ▼]

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to these populations. One condition influencing the relative contribution of recollection and familiarity during recognition is the format of the test. The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI in two tasks where the level of performance is equalized. Seventy young participants, 70 younger-old (55-69 years old), 69 older-old (70-85 years old), and 13 MCIs were presented with forced-choice and yes/no visual recognition memory tasks with the Remember/Know/ Guess paradigm. Young participants had better recognition memory performance than younger-old, who performed better than older-old and MCIs. Recollection and familiarity declined progressively in healthy aging. In MCI, recollection was more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. Young people used recollection more often in the forced-choice task compared to the yes/no task. [less ▲]

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See detailClinical pathway evaluation for left and sigmoid colectomy in abdominal surgery
Mattart, Laurine; Stevens, Marie; Magis, David ULiege et al

Poster (2017, May 19)

Detailed reference viewed: 14 (2 ULiège)
See detailTraiter l’alexithymie en Hôpital de Jour Psychiatrique : Identification des modulateurs favorisant une meilleure prise en charge
Nasello, Julian ULiege; Servais, Catherine; Close, Mireille et al

Poster (2017, May 19)

L’alexithymie (i.e., incapacité à exprimer ses émotions par des mots) serait-elle sensible aux traitements psychothérapeutiques dispensés en Hôpital de Jour (HPJ) ? Quelles en seraient les variables ... [more ▼]

L’alexithymie (i.e., incapacité à exprimer ses émotions par des mots) serait-elle sensible aux traitements psychothérapeutiques dispensés en Hôpital de Jour (HPJ) ? Quelles en seraient les variables prédictives ? Notre recherche a porté sur 73 participants sélectionnés en HPJ et présentant des troubles de l’humeur. En comparant les scores d’entrée et de sortie, des réductions significatives ont été observées sur tous les aspects d’alexithymie. De plus, certaines variables impactant significativement sur l’alexithymie ont été mises en avant : variables démographiques (i.e., genre ; âge ; durée de séjour) ; médication ; variables du MMPI-2 ; support social perçu (PSS). Il apparait que le PSS ainsi que cinq variables mesurées par le MMPI-2 (e.g., les pratiques antisociales ou les attitudes négatives face au traitement) tendaient à réduire ou augmenter les niveaux d’alexithymie. Dès lors, ces résultats tendent à favoriser une conception plus flexible des traits de personnalité, à mettre en évidence le rôle fondamental de la régulation exogène des émotions et à fournir aux thérapeutes les variables à prendre en considération pour optimiser la prise en charge de l’alexithymie. [less ▲]

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See detailDes jeux de doigts pour renforcer les précurseurs des apprentissages scolaire
Dauvister, Estelle; Vossius, Line ULiege; Rousselle, Laurence ULiege

Poster (2017, May 19)

Detailed reference viewed: 33 (1 ULiège)
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See detailVieillissement non pathologique des fonctions exécutives : influence du polymorphisme nucléotidique val108/158met du gène COMT
Gilsoul, Jessica ULiege; Manard, Marine ULiege; Collette, Fabienne ULiege

Poster (2017, May 19)

Introduction. Selon la Théorie des États-Duaux, les homozygotes Val sur le gène COMT possèderaient de meilleures capacités de flexibilité tandis que les individus Met/Met favoriseraient les capacités de ... [more ▼]

Introduction. Selon la Théorie des États-Duaux, les homozygotes Val sur le gène COMT possèderaient de meilleures capacités de flexibilité tandis que les individus Met/Met favoriseraient les capacités de stabilité. Ces effets génotypiques seraient amplifiés dans le vieillissement car la diminution des ressources cérébrales augmente l’influence des différences génétiques sur la cognition. Notre but est d’investiguer l’influence du polymorphisme nucléotidique COMTVal108/158Met sur les fonctions exécutives dans le vieillissement normal. Méthode. Trois fonctions exécutives ont été évaluées grâce à différentes tâches chez des participants jeunes (N=55) et âgés (N=45) portant l’un des génotypes du gène COMT (Val/Val, Val/Met, et Met/Met). Nous avons réalisé des tests t entre les deux groupes ainsi qu’une ANOVA 6 (Groupe : Jeunes-Met/Met, Jeunes-Val/Met, Jeunes -Val/Val, Âgés-Met/Met, Âgés-Val/Met, et Âgés-Val/Val) X 3 (Fonctionnement exécutif : Inhibition, Flexibilité, et Mise à jour) à mesures répétées avec le Fonctionnement exécutif comme facteur intra-sujet (p < ,05). Résultats. Jeunes et âgés différaient significativement sur les trois fonctions exécutives. Au sein des groupes jeunes et âgés, aucune différence significative n’a pu être mise en évidence entre les groupes génotypiques. De façon intéressante, le groupe des Âgés-Val/Val avait de plus faibles performances que le groupe des Jeunes-Val/Val en inhibition. Discussion. Comme attendu, nous avons trouvé un effet de l’âge sur toutes les fonctions exécutives. La différence entre les Jeunes-Val/Val et les Âgés-Val/Val en inhibition soutient l’idée d’une diminution avec l’avancée en âge des performances lorsqu’une composante de stabilité est requise par la tâche chez des individus possédant un génotype moins favorable pour cette composante. [less ▲]

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See detailAssociation entre régulation circadienne du cycle de veille-sommeil et performance de mémoire de travail chez les personnes âgées
Schmidt, Christina ULiege; Reichert, Carolin Franziska; Maire, Micheline et al

Poster (2017, May 19)

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, May 19)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Method. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region. Discussion. In a late middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects. [less ▲]

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See detailMécanismes de vieillissement des anodes à base de FeSn2 pour batteries Li-ion
Chamas, Mohamad; Mahmoud, Abdelfattah ULiege; Tang, junlei et al

Poster (2017, May 18)

Les intermétalliques d’étain ont été proposés comme matériaux d’anode pour batteries Li-ion à forte densité d’énergie car leur capacité spécifique est bien supérieure à celle des anodes commerciales à ... [more ▼]

Les intermétalliques d’étain ont été proposés comme matériaux d’anode pour batteries Li-ion à forte densité d’énergie car leur capacité spécifique est bien supérieure à celle des anodes commerciales à base de carbone. Le mécanisme électrochimique est basé sur la transformation irréversible de FeSn2 en un composite formé de nanoparticules de fer et de Li3.5Sn lors de la première lithiation, puis de réactions réversibles modifiant la composition de Li3.5Sn, les particules de fer assurant la dispersion de ces particules à base d’étain [1]. Cependant, nous avons observé que l’électrode lithiée était instable dans le temps conduisant à l’autodécharge progressive de la batterie [2]. Ce phénomène de vieillissement a été caractérisé par spectrométrie Mössbauer du 57Fe et de 119Sn, par spectroscopie d’impédance et par mesures magnétiques (Figure 1). On montre que le composite Fe/Li3.5Sn se délithie progressivement au cours du temps conduisant à un composite faiblement lithié Fe/LixSn avec x<1. Les nanoparticules de fer sont stables et ne réagissent pas avec LixSn. Les atomes de lithium libérés réagissent avec l’électrolyte et modifient la morphologie de la couche SEI (Surface Electrolyte Interphase) située à la surface des particules LixSn du composite.[1] M. Chamas, M. T. Sougrati, C. Reibel, P.E. Lippens, Chem. Mater. 25, 2410 (2015). [2] M. Chamas, A. Mahmoud, J. Tang, S. Panero, M. T. Sougrati, P. E. Lippens, J. Phys Chem. C 121, 217 (2017). [less ▲]

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See detailStructural and Magnetic Properties of Nanosized strontium Hexaferrite Powders: Experimental and theoretical investigation
Abraime, Brahim; Ait Tamerd, Mohamed; Mahmoud, Abdelfattah ULiege et al

Poster (2017, May 18)

Strontium M-type hexagonal ferrites were synthesized at different calcination temperatures (800 °C, 1000°C and 1100 °C) using sol-gel autocombustion method. Thermogravimetric analysis (TGA), X-ray ... [more ▼]

Strontium M-type hexagonal ferrites were synthesized at different calcination temperatures (800 °C, 1000°C and 1100 °C) using sol-gel autocombustion method. Thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Mössbauer spectroscopy (MS) and superconducting quantum interference device magnetometer (SQUID) techniques were used to characterize crystal structure, phase composition, morphology and magnetic properties. TGA gives T=800 °C as beginning of suitable calcination. Hexaferrite structure of single phase is obtained according to XRD results for all samples with crystallite size between 28 nm and 35 nm. SEM images show the growth of grain size with increasing of annealing temperature. (BH)max is calculated based on SQUID results and shows an enhancement between T=800°C and T= 1000°C of 25%. The magnetic properties observed at low temperature are explained and confirmed by ab-initio calculations. [less ▲]

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See detailAharonov-Bohm oscillations of bosonic matter-wave beams in the presence of disorder and interaction
Chrétien, Renaud ULiege; Dujardin, Julien; Petitjean, Cyril ULiege et al

Poster (2017, May 17)

We study the one-dimensional (1D) transport properties of an ultracold gas of Bose-Einstein condensed atoms through Aharonov-Bohm (AB) rings. Our system consists of a Bose-Einstein condensate (BEC) that ... [more ▼]

We study the one-dimensional (1D) transport properties of an ultracold gas of Bose-Einstein condensed atoms through Aharonov-Bohm (AB) rings. Our system consists of a Bose-Einstein condensate (BEC) that is outcoupled from a magnetic trap into a 1D waveguide which is made of two semi-infinite leads that join a ring geometry exposed to a synthetic magnetic flux φ. We specifically investigate the effects both of a disorder potential and of a small atom-atom contact interaction strength on the AB oscillations. The main numerical tools that we use for this purpose are a mean-field Gross-Pitaevskii (GP) description and the truncated Wigner (tW) method. We find that a correlated disorder suppress the AB oscillations leaving thereby place to weaker amplitude, half period oscillations on transmission, namely the Aronov-Al’tshuler-Spivak (AAS) oscillations. The competition between disorder and interaction leads to a flip of the transmission at the AB flux φ = π. This flip could be a possible preliminary signature of an inversion of the coherent backscattering (CBS) peak. Our study paves the way to an analytical description of the inversion of that peak. [less ▲]

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See detailModulation of NMDA receptor mediated excitatory synaptic currents in dopamine neurons of the substantia nigra
Destreel, Geoffrey ULiege; Seutin, Vincent ULiege; Engel, Dominique ULiege

Poster (2017, May 17)

Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) exhibit two main firing modes, spontaneous single action potential (AP) firing and bursting. The amount of DA released by these neurons in ... [more ▼]

Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) exhibit two main firing modes, spontaneous single action potential (AP) firing and bursting. The amount of DA released by these neurons in target areas depends on the presynaptic AP firing pattern and is essential to modulate several aspects of behavior such as the control of movement. Bursting activity is mediated by excitatory afferents and specifically by the activation of NMDA receptors (NMDARs). However, the level of activation of NMDARs at these synapses during spontaneous synaptic activity is unknown. We assessed the occupancy of the glycine binding sites of the NMDAR by testing the effects of coagonists and by blocking the uptake of glycine on spontaneous excitatory postsynaptic currents (sEPSCs) in DA neurons of the SNc. Parasagittal midbrain slices (300 – 350 µm thickness) were cut from the brains 16- to 26- days old Wistar rats using a vibratome. Whole-cell recordings were made using warm (~35C°) standard artificial cerebrospinal fluid. sEPSCs were pharmacologically isolated and recorded at +40 and -70 mV. A large NMDAR-sEPSC component was present at +40 mV as revealed by the application of 50 µM D-AP5 (n=8, P < 0.001). At -70 mV, D-AP5 had no effect on the EPSC, as expected (n=7, P = 0.52). The mean amplitude of the average NMDAR sEPSC measured at +40 mV increased significantly from 8.6 ± 0.8 pA in control conditions to 10.9 ± 1.0 pA during bath application of 300 μM glycine (n=10, P < 0.001). We also investigated the effect of D-serine, the other coagonist at the NMDAR glycine site. The mean NMDAR EPSC amplitude measured at +40 mV showed a tendency toward larger values, from 6.8 ± 0.8 pA in control conditions to 8.8 ± 1.1 pA in the presence of 100 µM D-serine (n=4). Blockade of the glycine transporter-1 (GlyT1) significantly increased the mean amplitude of NMDAR sEPSCs measured at +40 mV from 7.1 ± 0.5 pA in control conditions to 10.5 ± 0.8 pA in the presence of 5 μM NFPS (n=8, P < 0.001). At -70 mV, NFPS had no effect on the AMPAR-sEPSC component, as expected (n=8, P = 0.23). In conclusion, our results indicate that the NMDAR glycine sites are not saturated by glycine and D-serine during sEPSCs in control conditions. [less ▲]

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See detailUse of a bio-based binder in the building sector
Gerbinet, Saïcha ULiege; Briard, Vincent; Pigeolet, Jean-Pierre et al

Poster (2017, May 15)

A binder is a material or a substance that holds materials together, like a glue. In the building sector, binders have several applications: they can be used in producing wood panels such as MDF to paste ... [more ▼]

A binder is a material or a substance that holds materials together, like a glue. In the building sector, binders have several applications: they can be used in producing wood panels such as MDF to paste together the wood particles and give the panels their stabil-ity. They are also used in insulation materials, such as glass wool or stone wool to bind the fibers together. Traditional binders are mostly fossil-based (phenol-formaldehyde, urea-formaldehyde, etc.), and previous Life Cycle Assessments (LCA) [1-3] show that these binders, even if they are a minor component on a mass basis, can have a major contribution to the environmental impact of the material, especially in wood panels. In addition, the use of these binders has raised some sanitary questions, especially con-cerning indoor air quality. Therefore alternative binders are being investigated, namely bio-based binders. In this presentation, we focus on the ECOSE binder, developed by Knauf Insulation, a global building insulation manufacturer. It has the particularity of being based on plant starch and it is currently used in glass wool products, while other applications are being developed. We underline that using biomass as raw materials instead of fossil-based ma-terials could have several benefits on the environment, especially fossil resources deple-tion and CO2 emissions, but that this is not necessarily the case for all environmental as-pects, for instance land use, even if only the direct land use is included in this study. The presentation will first underline the differences in term of environmental impact be-tween the traditional binder and ECOSE applied in glass mineral wool. Indeed, a compar-ison on a mass basis is not totally relevant: two binders can have different application conditions; therefore, we can only compare them at the application level. But the main focus of the presentation will be on the hypothesis made in the modeling of the biomass part and their influence on the results. For example, the influence of the use of bio-based raw materials instead of traditional ones will be studied, but also the influence of the dis-tance between farm and factory where the starch is produced. The use of local data will be compared with the use of databases. All these results will highlight the difficulties in studying bio-based products and to compare them with fossil-based ones. The use of LCA and a complete analysis of the results are essential to better understand the chal-lenges related to binder technology modification. ________________________________________ 1. Rivela, B., et al., Life cycle inventory of particleboard: A case study in the wood sector. International Journal of Life Cycle Assessment, 2006. 11(2): p. 106-113. 2. Wilson, J.B., Particleboard: A Life-Cycle Inventory of Manufacturing Panels from Resource through Product, in CORRIM: Phase II Final Report. 2008, Department of Wood Science and Engineering, Oregon State University. 3. Silva, D.A.L., et al., Environmental performance assessment of the melamine-urea-formaldehy (MUF) resin manufacture: a case study in Brazil. Journal of Cleaner Production, 2015. 96. [less ▲]

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See detailEcodesign of a “vapour and air barrier membrane – insulator” system, following a cradle-to-cradle approach – ATISOL C2C
Groslambert, Sylvie ULiege; Léonard, Angélique ULiege; Getlicherman, Michel et al

Poster (2017, May 15)

Buildings account for 40% of the total energy consumption of the European Union. This sector is growing, as its energy demands. The construction sector is also one of the most important contributors of ... [more ▼]

Buildings account for 40% of the total energy consumption of the European Union. This sector is growing, as its energy demands. The construction sector is also one of the most important contributors of waste generated at the EU level (up to one third). The European directive on the energy efficiency of buildings requires the members to put on the market solutions for insulation of buildings that are simple, effective and last-ing, but also respectful of the environment and of the users. A low energy consumption house requires to be thermally insulated and to have an ef-fective ventilation. To reduce energy losses and to guarantee the durability of the thermal insulation, it is necessary to have a vapor and air barrier on the warm side of the building, situated between the thermal insulation and the inside. Hence the passage of moisture in the building is reduced, preventing condensation problems in the insulating material. Cur-rently, the implementation of an insulation system combined with a vapor barrier presents three major problems: an important time for placing, a random durability in time (durabil-ity of tapes of junction, adherence to the existing walls, punching resistance), and finally a low disassembly and re-use level. As part of the improvement of energy performance of buildings, the ATISOLC2C pro-ject aims to develop a complete solution (insulation + vapor barrier + coating), with the lowest environmental impact on its whole life cycle. The solution combines a renewable vapor/air barrier combined with ecological insulation. The solution can be used both in new construction in timber or during renovation. The constructive system will be validated in both existing building and new construction. Compared to the state of the art, the solution that is developed is unique and innova-tive by its simplicity in terms of materials by integration of a vegetal self-adhesive binder to the spunbond reinforcement of the membrane, itself obtained from renewable re-sources. The material is appropriate for application on the different wall coverings exist-ing in a building. Due to the self-adhesive characteristics, the implementation is made easier in both common surfaces (walls, roofs and ceilings) and to the level of detail such as corners and junctions. In addition, the application of a natural top coating on the membrane completes the offer. The constructive system can be dismantled at the end-of-life of the building and the various elements are recovered and valued in a cradle-to-cradle perspective. At the level of the consortium, the development and commercialization of the ATISOL solution is achieved through the close partnership between Derbigum and Sioen Felt & Filtration, and with the scientific and technical support of the University of Liège, Cen-texbel and the Belgian Building Research Institute. A life cycle assessment supports the whole project to quantify the environmental impacts of both raw materials and processes (manufacturing, installation and dismantling). The aim is to ensure that the selected solu-tion is the most sustainable and that it is environmentally better than existing products on the market. This project is supported by the GreenWin Competition Clusters and subsidized by the Walloon Region (BE). [less ▲]

Detailed reference viewed: 26 (2 ULiège)
Peer Reviewed
See detailBelgian speleothem records Holocene cold events?
Allan, Mohammed ULiege; Deliège, Adrien ULiege; Nicolay, Samuel ULiege et al

Poster (2017, May 12)

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and ... [more ▼]

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and peat cores. High spatial resolution measurements of Mg, Al, Sr, Ba were realized by using laser-ablation inductively coupled plasma mass spectrometry in the Belgian Pere Noel cave. A stalagmite from the Pere Noel (PN) cave representing 12000 years dated by U/Th method. Trace element variations in speleothem are a reflection of hydrochemical conditions. These changes were interpreted as indications of changes in climate in the Han-sur-Lesse region. The similar patterns found in δ 18O, δ 13C and chemical composition along the Pere Noel stalagmite suggests that trace elements in speleothems have the potential to provide high resolution insights into palaeoclimatic variability during the Holocene. A deeper analysis reveals several periods of significant rapid climate change during the Holocene (at 10.7-9.2 ka, 8.2-7.9 ka, 7.2-6.2 ka, 4.8-4.5 ka, and 3-2.4 ka BP), which are similar to the cold events detected from different natural paleoclimate archivers. A comparison between the geochemical analysis of Père Noël speleothem and solar activity (sunspot number) reveals a significant correlation. Spectral analysis methods reveal common solar periodicities (Gleissberg cycle, de Vries cycle, unnamed 500 year, Eddy cycles, and Hallstatt cycle). The geochemical analyses have the potential to prove that PN speleothem is sensitive to changes in solar activity on centennial and millennial timescales during the Holocene. [less ▲]

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See detailStudy of the regulation of the operon ftsW-psr-pbp5 in Enterococcus hirae
Raymackers, Alice ULiege; Maréchal, Maxime; Verlaine, Olivier ULiege et al

Poster (2017, May 11)

Detailed reference viewed: 24 (6 ULiège)
Peer Reviewed
See detailCrosstalk between VEGF and BMP9 pathway. Implications in HHT disease
Pollenus, Thomas ULiege

Poster (2017, May 11)

Detailed reference viewed: 12 (2 ULiège)
See detailMAGED2 function as cell cycle regulator after a genotoxic stress
Trussart, Charlotte ULiege; Pirlot, Céline; Piette, Jacques ULiege et al

Poster (2017, May 11)

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See detailToRQuEMaDA: Tool for retrieving queried eubacteria, metadata and dereplicating assemblie
Léonard, Raphaël ULiege; Sirjacobs, Damien ULiege; Sauvage, Eric ULiege et al

Poster (2017, May 11)

The fast-growing number of available prokaryotic genomes, along with their uneven taxonomic distribution, is a problem when trying to assemble broadly sampled genome sets for phylogenomics and comparative ... [more ▼]

The fast-growing number of available prokaryotic genomes, along with their uneven taxonomic distribution, is a problem when trying to assemble broadly sampled genome sets for phylogenomics and comparative genomics. Indeed, most of the new genomes belong to the same subset of hyper-sampled phyla, such as Proteobacteria and Firmicutes, or even to single species, such as Escherichia coli (>3000 genomes as of March 2017), while the continuous flow of newly discovered phyla prompts for regular updates of in-house databases. This situation makes it difficult to maintain sets of representative genomes combining lesser known phyla, for which only few species are available, and sound subsets of highly abundant phyla. An automated method is required but none are publicly available. In this work, the kmer composition of DNA sequences, in conjunction with quality metrics for publicly available assemblies, was used to develop an automated approach for selecting a high-quality subset of representative genomes without redundancy by using our hybrid divide-and-conquer / greedy clustering method. [less ▲]

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Peer Reviewed
See detailLacustrine clay mineral assemblages as a proxy for land-use and climate changes over the last 4 kyr: The Amik Lake
El Ouahabi, Meriam ULiege; Hubert, Aurelia ULiege; Allan, Mohammed ULiege et al

Poster (2017, May 10)

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital ... [more ▼]

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital fraction, the lacustrine sediments record the history of soil erosion within its catchment via the inputs of clays and others detrital products. Within a Mediterranean context, the study investigates the upper sediments infilling the central part of the Amik basin in southern Turkey. This tectonic basin was occupied and exploited by modern human at least since 6000-7000 BC. We focus on the clay mineralogy (x-ray diffraction on oriented aggregates) and magnetic susceptibility measurements (Bartington) of the sedimentary record in the area over the last 4000 years, to assess environmental changes in relation with the different land uses and/or weathering during the successive Bronze, Iron, Roman, Islamic/Ottoman and Modern civilizations. The clay fraction of Amik Lake sediments comprises smectite, kaolinite, illite, chlorite and chlorite/smectite mixed layers that are the inherited clay phases. A relative change in abundance and crystallinity and chemistry of illite attests that environmental conditions evolved in the Amik Plain from the Bronze to Modern Age in relation with climates and/or land-use changes. The history of the Amik Lake reveals different soil erosion episode. The most intense erosion phase occurred during the Bronze/Iron Ages as indicated by the clay and magnetic susceptibility proxies. The Roman period was an exceptional period with soil erosion products arriving from the watershed, probably due the water channelization. A reduction of soil erosion occurred during the post Roman period until nowadays. Significant pedogenesis transformations are evidenced, especially during the Islamic/Ottoman periods suggesting intense chemical weathering conditions related to climate change. [less ▲]

Detailed reference viewed: 82 (15 ULiège)
Peer Reviewed
See detailSmart-shoes self-powered by walking
Colson, Gérald ULiege; Laurent, Philippe ULiege; Bellier, Pierre ULiege et al

Poster (2017, May 10)

Nowadays, electronic devices are more and more compact and can be integrated in nearly every object. One of the remaining challenges is to provide smarter ways to power those electronic devices. Because ... [more ▼]

Nowadays, electronic devices are more and more compact and can be integrated in nearly every object. One of the remaining challenges is to provide smarter ways to power those electronic devices. Because of the small amount of energy needed by the latest ultra-low power systems, energy harvesting from the environment becomes a viable solution to power them. In this work, we present the integration of an electronic device and an electrodynamic energy harvester (EH) in a shoe. The electronic device measures the acceleration along one axis at a sampling rate of 30 Hz and sends the data every second using a wireless link. The data are then collected by a gateway and processed to count the number of steps, calculate the contact time and the flying time of the foot. To perform this function, the device requires an average power of 951 μW which is provided by the EH. [less ▲]

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Peer Reviewed
See detailInnovative silage additives to reduce proteolysis in the silo
Herremans, Sophie ULiege; Decruyenaere, Virginie; Beckers, Yves ULiege et al

Poster (2017, May 10)

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See detailLife Cycle in Practice – Helping SMEs to integrate life cycle approach in their policy
Groslambert, Sylvie ULiege; Léonard, Angélique ULiege

Poster (2017, May 10)

The application of Life Cycle Approaches – including Life Cycle Assessment, eco-design and environmental labelling – is becoming an increasing reality for business, and a growing challenge in many ... [more ▼]

The application of Life Cycle Approaches – including Life Cycle Assessment, eco-design and environmental labelling – is becoming an increasing reality for business, and a growing challenge in many economic sectors. Businesses are facing increasing legal and market requirements to enhance resource efficiency and reduce the environmental impact of their products & services. To significantly address this challenge, the Life Cycle in Practice project (LCiP - LIFE12 ENV/FR/001113) was conceived, aiming to promote the uptake of LC approaches particularly in SMEs. The overall aim of the LCiP project is to help SMEs in France, Belgium, Portugal and Spain in reducing the environmental impacts of their products and services across the entire Life Cycle and to foster the implementation of circular economy in these regions. Three sectors are selected: Buildings & Construction, Waste Management and Energy Equipment. Thirty-two businesses are involved in the four regions, twelve being located in Wallonia. GreenWin, the Walloon partner, has mandated several teams well-known for their expertise in LCA to coach them. ULg-PEPs coached three SMS's to help them to carry out the Life Cycle Assessment (LCA) of their product and accordingly to identify the strengths and weakness of the products and/or processes. Two of them are involved in building insulation (hemp con-crete blocs from IsoHemp and sound insulation panels Acoustix made by Pan-Terre), and the third one is developing an accelerated composting equipment for food waste (EcoCleaner). Concretely, the LCA of the three products are realised in a cradle to gate perspective. The results show possible environmental impact improvement for all the products, even if they are eco-designed. As a coach, the experience of working closely with highly motivated people in small structures is very gratifying and a smart way to help life cycle approaches to develop in our region. We are pleased to go on this initiative by hosting one of the Physical Resource Centres in the University of Liège to welcome SMEs seeking to integrate LC approaches into their businesses, and give them access to selected LCA tools, reading material, expertise, training and advice. Results and Online Resource Centre are centralised on the LCiP website: http://www.lifelcip.eu/. [less ▲]

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Peer Reviewed
See detailGlucose production: influence of the datasets and of the long term emissions on LCA results
Gerbinet, Saïcha ULiege; Belboom, Sandra ULiege; Léonard, Angélique ULiege

Poster (2017, May 08)

The aim of this study is to have a good understanding of the environmental impact of glucose production. Glucose is generally produced from corn or wheat. Since agricultural processes are known to be ... [more ▼]

The aim of this study is to have a good understanding of the environmental impact of glucose production. Glucose is generally produced from corn or wheat. Since agricultural processes are known to be difficult to evaluate by LCA, the results obtained with two different LCA databases, Gabi and EcoInvent, are compared in this work. The production of glucose from raw materials can be divided in two steps: the agricultural step allowing the cereal production, and the conversion step including the extraction of the starch from the plant and its hydrolysis into glucose. Preliminary results underline the high impact of the agricultural step, so a special attention has been paid to these data. Specific Belgian data collected by the Walloon Agricultural Research Centre (CRA-W) (2014) [1] have been used as primary data (yield, amount of fertilizers, etc.), either using EcoInvent or Gabi datasets background data to model fertilizers, diesel consumption, etc. A third model was built using only data available in Ecoinvent for corn and wheat cultures. For the conversion steps, literature data have been used along with some industrial data. Based on these multiple sources, it is possible to compare the LCA results for the production of 1 kg of glucose for three different cases. The results underlined that the differences between the two databases are smaller than the differences between specific data (Belgium data) or non-specific data (Ecoinvent) for the agricultural steps. Nevertheless, in some impact categories, the differences between the two databases remain high. The presentation will underline where these differences are coming from. This leads to also analyze the differences between background data such as energy generation or fertilizer production. Moreover, special attention has been put on the influence of long-term emissions, in the Ecoinvent database. As these emissions have a large influence in some impact categories, we have to clarify if we should include them or not in view of comparison with GaBi database. Moreover, the Ecoinvent model and the GaBi models have been realized in two different software (Simapro and GaBi, respectively), therefore, some checks have been performed to see if some differences can be induced by the software. In conclusion, this presentation will underline which is the sensibility of the results to parameters not controlled by the LCA practitioner, such as the datasets hypotheses, the software differences, etc. 1. Walloon Agricultural Research Centre (CRA-W), ALT4CER project. 2014. [less ▲]

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See detailMONitOring des flux de POLluants dans les Eaux Souterraines
Jamin, Pierre ULiege; Dassargues, Alain ULiege; Brouyère, Serge ULiege

Poster (2017, May 05)

Contaminated aquifers management is currently based on the evaluation of pollutant concentration in the groundwater. This approach is necessary but totally insufficient to evaluate the risk posed by the ... [more ▼]

Contaminated aquifers management is currently based on the evaluation of pollutant concentration in the groundwater. This approach is necessary but totally insufficient to evaluate the risk posed by the contamination to potential receptors. Since the risk is due to the pollutant that are actually moving, and might reach a receptor, this concentration measurement should be combined to a measurement of the groundwater flow velocity (i.e. the driving force of contaminant migration in aquifers), to quantify the contaminant mass flux at which the receptor is exposed. We propose a new point dilution technique able to measure accurately the groundwater flux and to monitor continuously its changes with time. [less ▲]

Detailed reference viewed: 43 (9 ULiège)
See detailDesign of new reprocessable shape-memory materials
Defize, Thomas ULiege; Riva, Raphaël ULiege; Thomassin, Jean-Michel ULiege et al

Poster (2017, May 04)

Detailed reference viewed: 11 (2 ULiège)
See detailSynthesis of cross-linked poly(HEMA) microparticles in supercritical carbon dioxide for sustained delivery
Caprasse, Jérémie ULiege; Parilti, Rahmet ULiege; Riva, Raphaël ULiege et al

Poster (2017, May 04)

Microgels are micro-sized polymer networks able to swell or shrink depending on the environment. They find applications in many fields such as for environmental purpose or especially in the biomedical ... [more ▼]

Microgels are micro-sized polymer networks able to swell or shrink depending on the environment. They find applications in many fields such as for environmental purpose or especially in the biomedical field for tissue engineering or controlled drug-delivery applications. Indeed, the use of microgels allows a controlled and sustained release of an encapsulated active ingredient (AI), avoiding Burst release. This work aims at reporting on the solvent-free synthesis of well-defined hydrogel microparticles according to a free radical dispersion polymerization of hydroxyethyl methacrylate (HEMA) in supercritical carbon dioxide (scCO2) which confers environmentally benign features to the process2. For that purpose, a dedicated polymer surfactant has been designed by RAFT polymerization, i.e. poly(ethylene oxide-b-heptadecafluorodecyl acrylate) diblock copolymer with a photocleavable group at the junction of both blocks and used as stabilizer for the HEMA dispersion polymerization in scCO2. The synthesis conditions (stabilizer concentration, temperature and CO2 pressure,…) adapted for the in situ encapsulation of an active ingredient have been studied. Then, the photocleavage of the fluorinated block of the polymer stabilizer allows the further swelling of the polyHEMA particles in water and the sustained release of the encapsulated active ingredient through the microgels. This eco-friendly process allowing the formation of well-defined hydrogel particles, showing a sustain release of their content is quite promising for a high scale microparticles production. Microgels are micro-sized polymer networks able to swell or shrink depending on the environment. They find applications in many fields such as for environmental purpose or especially in the biomedical field for tissue engineering or controlled drug-delivery applications. Indeed, the use of microgels allows a controlled and sustained release of an encapsulated active ingredient (AI), avoiding Burst release. [less ▲]

Detailed reference viewed: 80 (2 ULiège)
See detailThiol-ene reaction: an efficient tool to design polyphosphoester-based drug delivery systems
Riva, Raphaël ULiege; Vanslambrouck, Stéphanie; Ergül, Zeynep ULiege et al

Poster (2017, May 04)

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromolecules, polyphosphoesters (PPE) are appealing polymers for biomedical applications. In contrast to ... [more ▼]

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromolecules, polyphosphoesters (PPE) are appealing polymers for biomedical applications. In contrast to polyesters, PPE properties and functionality are easily tuned via the chemical nature of the lateral chains. To enhance the drug loading capacity of PPE-based micelles used as carriers for the delivery of poorly soluble drugs, an efficient strategy to increase the lipophilicity of the PPE block of polyethylene oxide (PEO)-b-PPE amphiphilic copolymers has been investigated. A PEO-b-PPE copolymer bearing pendant vinyl groups along the PPE block was synthesized and then modified by thiol-ene click reaction with thiols bearing either a long linear alkyl chain (dodecyl) or a tocopherol moiety. Ketoconazole was used as model for hydrophobic drugs. Comparison of the loading contents and release profiles with PEO-b-PPE bearing shorter pendant groups is presented evidencing the key role of the structure of the pendant group on the PPE backbone. Finally, the low cytotoxicity of these novel PEO-b-PPE copolymers was also demonstrated. The tocopherol derivative was evidenced as particularly promising for drug delivery systems. [less ▲]

Detailed reference viewed: 61 (2 ULiège)
See detailDesign of polyphosphoester coplymers as scaffolds for tissue engineering applications
Shah, Urmil ULiege; Ergül, Zeynep ULiege; Jérôme, Christine ULiege

Poster (2017, May 04)

Polymers with repeating phosphoester linkages in the backbone are biodegradable and emerged as a promising class of novel biomaterials. In contrast to polyesters, the pentavalency of the phosphorus atom ... [more ▼]

Polymers with repeating phosphoester linkages in the backbone are biodegradable and emerged as a promising class of novel biomaterials. In contrast to polyesters, the pentavalency of the phosphorus atom offers a large diversity of structures and as a consequence a wide range of properties for these materials. This study aims at taking profit of this easy functionalization to synthesize a series of degradable polymers of precisely tailored properties especially elasticity, hydrophilicity and functionality. We aim at developing a set of degradable materials in which only elasticity is varied keeping unchanged other parameters such as hydrophilicity, which remains quite a challenge. For that purpose, we have synthesized by organocatalyzed ring-opening polymerization,random di- and terpolymers between various cyclic phosphoesters bearing a short side-chain (hydrophilic), a longer side-chain (hydrophobic) and an unsaturated side-chain (butenyl)able to cross-link under UV irradiation. Playing on the composition of these copolymers, the cross-linking density and the hydrophilicity can be tuned quite independently. In the future, these materials will be used as model scaffolds to study the growth and differentiation of stem cells. [less ▲]

Detailed reference viewed: 114 (8 ULiège)
See detailAll poly(ionic) liquid-based block copolymers incorporating fluorinated and triethyleneglycol units: direct synthesis in water and investigation as single-ion conductive solids
Ouhib, Farid ULiege; Cordella, Daniela; Aqil, Abdelhafid ULiege et al

Poster (2017, May 04)

Poly(ionic liquid)s (PILs) have attracted a considerable attention as innovative single-ion solid polyelectrolytes (SPEs) in substitution to the more conventional electrolytes for a variety of ... [more ▼]

Poly(ionic liquid)s (PILs) have attracted a considerable attention as innovative single-ion solid polyelectrolytes (SPEs) in substitution to the more conventional electrolytes for a variety of electrochemical devices. Imidazolium-based PILs are amongst the most investigated, because they are easy to synthesize and some of them have shown a good combination between high ionic conductivity, wide chemical and electrochemical stability, and good mechanical properties. Herein, we report the precise synthesis, characterization, and use as single-ion SPE of a novel double PIL-based amphiphilic diblock copolymer (BCP), i.e. where all monomer units are of N-vinyl-imidazolium-type, with triethylene glycol pendant groups in the first block, and a statistical distribution of N-vinyl-3-ethyl- and N-vinyl-3-perfluorooctyl-imidazolium bromides in the second block. BCP synthesis is achieved directly in water by a one-pot process, following the principle of the cobalt-mediated radical polymerization-induced self-assembly (CMR-PISA). A subsequent anion exchange reaction substituting bis(trifluoromethylsulfonyl)imide (Tf2N-) for bromide (Br-) counter-anions leads to the targeted PIL BCPs with two different lengths of the first block. They demonstrate ionic conductivity σDC = 1-3 10-7 S cm-1, as determined by broadband dielectric spectroscopy at 30 °C (under anhydrous conditions), and form free standing films with mechanical properties suited for SPE applications with Young’s modulus of 3.8 MPa and elongation at break of 250 % as determined by stress/strain experiments. [less ▲]

Detailed reference viewed: 103 (3 ULiège)
See detailReinforced poly(hydroxyurethane) coatings and high performance adhesive
Panchireddy, Satyannarayana ULiege; Grignard, Bruno ULiege; Thomassin, Jean-Michel ULiege et al

Poster (2017, May 04)

Polyurethane (PU) is one of the most widely used polymeric materials and largely valorised in coating applications as paints or as adhesives. Because toxicity issues of isocyanates and changes in the ... [more ▼]

Polyurethane (PU) is one of the most widely used polymeric materials and largely valorised in coating applications as paints or as adhesives. Because toxicity issues of isocyanates and changes in the environmental and REACH regulations, there is a need today to develop new greener and safer alternatives to produce PU. One of the most promising way relies on the synthesis of polyurethane by a non-isocyanate route (NIPU) by copolymerization between a bicyclic carbonate monomers and a diamine. This study reports on the synthesis of new sustainable NIPU coatings for Al anti-corrosion protection and for metal adhesion. In a first step, (bio- and) CO2-sourced cyclic carbonates will be synthesized by coupling of multifunctional epoxides with CO2 using a new efficient bicomponent organocatalyst. In a second step, various cyclic carbonates/amines formulations were developed and cured in presence of fillers to produce reinforced NIPUs thermosets which anti-corrosion and adhesive properties are evaluated and benchmarked with existing formulations. Some formulations present outstanding adhesions to various substrates. [less ▲]

Detailed reference viewed: 67 (5 ULiège)
See detailQuantifying coral colony morphology to assess their roles in ecosystem processes
Chen, Qi; Yang, Emma; Sturaro, Nicolas ULiege et al

Poster (2017, May 04)

Colony morphology is among the best predictors of the scleractinian coral’s function in the reef ecosystem. However, morphological traits are categorical and to convert this information into a ... [more ▼]

Colony morphology is among the best predictors of the scleractinian coral’s function in the reef ecosystem. However, morphological traits are categorical and to convert this information into a quantitative value remains a real challenge to quantify the influence of this parameter on ecosystem processes. Recently, the ratio between colony mass and surface area (CMA) has been proposed to represent a suitable proxy of species morphologies and their growth. Hypothetically, CMA could be used to assess a broad range of biological, ecological, and evolutionary processes in coral reef ecosystem. Here, we propose to test CMA as a predictor of coral morphology and focus on the intraspecific variation of this parameter. We used historical coral collection from the Museum of Zoology (National Taiwan University) and our own specimens collected from contrasting environments to establish a database of coral models using a high-resolution David 3D scanner. From these models, we extracted surface area and volume of the coral colonies. Colony mass was measured on a Mark S Bel balance. CMA was compared for its power in predicting species morphology with other traits such as skeleton density. Eventually, we tested the use of CMA at an intraspecific level to detect plasticity in growth rate. Our 3D models are available online (http://www.dipintothereef.com/corals.html) and constitute a valuable resource for estimating the roles of corals in the ecosystem. [less ▲]

Detailed reference viewed: 53 (1 ULiège)
See detailSynthesis of hierarchical N-doped porous carbon structure/nanospheres Fe2O3 composites and its application in lithium-ion battery as lithium-ion anodes
Alkarmo, Walid ULiege; Ouhib, Farid ULiege; Aqil, Abdelhafid ULiege et al

Poster (2017, May 04)

Nitrogen-doped porous carbons are of special interest, because their unique physical properties such as high surface area, multidimensional electron transport pathways and good mechanical strength, and ... [more ▼]

Nitrogen-doped porous carbons are of special interest, because their unique physical properties such as high surface area, multidimensional electron transport pathways and good mechanical strength, and are thus very important for applications in the fields of catalysis, environment techniques and energy generation and storage. Moreover, nitrogen-doping can be further amplified in a porous structure that bears a high surface area to increases their materials performance in electrochemical devices, such as double layer capacitors and lithium-ion batteries. In addition, nitrogen-doping can enhance the lithium insertion, between the nitrogen-doped carbon material and lithium. And it can create a large number of defects in the porous configuration and offer more active sites for lithium insertion. Toward this goal, a hierarchically structured macro- and mesoporous N-doped carbon with dispersed Fe2O3 nanoparticles (NDC@Fe2O3) is prepared by thermal treatment of a novel composite composed by PMMA particles decorated by graphene oxide (GO), PPy and iron salts. The NDC@Fe2O3 composite exhibited high surface area with a hierarchical pores structure. Integrated as a lithium ion battery anode, NDC@Fe2O3 exhibited high reversible capacity of 930 mA h/g over 200 cycles. The combination of Fe2O3 nanoparticles with nitrogen-doped porous carbons to form hybrid anode has been an efficient way to maintain the electronic integrity of the whole electrode since the carbon acts as a buffer layer to accommodate the volume variation and to provide multidimensional electron transport pathways during the charge/discharge process. [less ▲]

Detailed reference viewed: 102 (9 ULiège)
See detailPhoto-crosslinkable hydrogel for guided periodontal tissue regeneration
Chichiricco, Pauline Marie ULiege; Riva, Raphaël ULiege; Thomassin, Jean-Michel ULiege et al

Poster (2017, May 04)

Periodontitis is an inflammatory disease resulting from the presence of oral bacteria biofilm in periodontal tissue, which destroys the tooth-supporting attachment apparatus. Untreated inflammation can ... [more ▼]

Periodontitis is an inflammatory disease resulting from the presence of oral bacteria biofilm in periodontal tissue, which destroys the tooth-supporting attachment apparatus. Untreated inflammation can spread to the gum tissue and lead, ultimately, to the loosening of the supporting tooth bone, with the risk that the tooth eventually falls. Guided Tissue Regeneration is a technique based on the application of a barrier membrane designed to prevent colonization of the wound space by epithelial cells from soft tissues. Indeed, these cells, characterized by a faster migration and proliferation rate compared to bone and periodontal ligament cells, could interfere with the regeneration process. In previously work Struillou et al. demonstrated the benefit effect of silated hydroxypropylmethylcellulose (Si HMPC)-based hydrogel can act as an efficient physical barrier in periodontal defect. Typically, this material is able to form a 3D network through the condensation of silanoate groups at physiological pH. However, a decrease of gelation time is necessary to assure the stability in peripheral part of the wound. In this project, we developed an injectable photo-crosslinkable membrane based on methacrylated carboxymethyl chitosan (CMCs) and Si HPMC that can be applied as a viscous solution and cured in situ in presence of a photoinitiator system made of riboflavin and triethanolamine. A visible light lamp (λ 420-480 nm), already used in dentistry, was preferred over a UV lamp. The addition of methacrylated polymer increase the stability of the material and increase the mass loss, in order to improve the bioresorption of the membrane. The chemical grafting of methacrylated carboxymethyl chitosan was characterized by 1H NMR and Infrared Spectroscopy. The gel point of the solution was determined by rheology and remained compatible with a clinical application. Moreover, the biocompatibility of this biomaterials was tested using murine cells using two assay: Neutral Red assay and MTT Cell Proliferation Assay. The in vitro tests validate the chemical synthesis in a biological point of view. The irradiation on cells and the direct contact with hydrogel doesn’t have an impact on cells viability. The capability of this material to act as a physical barrier was also evaluated using human gingival fibroblast. The cells were isolated from human gum explant before being put in contact with the hydrogel. After four days of contact no cells invasion was observed in the hydrogel using confocal microscopy. These preliminary results are quite promising for the development of novel injectable systems for Guided Periodontal Regeneration. In the future work, in vivo assays will be performed in Periodontal defect in a canine model. [less ▲]

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See detailSynthesis of well-defined polyvinylamine-containing copolymers via organometallic-mediated radical polymerization
Stiernet, Pierre ULiege; Demarteau, Jérémy ULiege; Jérôme, Christine ULiege et al

Poster (2017, May 04)

Polyvinylamine (PVAm) is a useful polymer involved in a large range of applications including paper coating, surface engineering, membrane separation, etc. It is commonly produced via free radical ... [more ▼]

Polyvinylamine (PVAm) is a useful polymer involved in a large range of applications including paper coating, surface engineering, membrane separation, etc. It is commonly produced via free radical polymerization of N-vinylformamide (NVF) or N-vinylacetamide (NVA) followed by hydrolysis of the pendent amides of the resulting polymers. Due to the lack of stabilizing group on the double bond of N-vinylamides, the controlled radical polymerization of these monomers remained a challenge for a long time, preventing the preparation of well-defined PVAms. Recently, our group reported the controlled polymerization of NVA via reversible deactivation of the growing radical chains with cobalt complexes. Moreover, the use of well-defined PVAms as efficient carriers for gene transfection was demonstrated. This communication aims at reporting the synthesis of novel well-defined polyvinylamine-based copolymers. First, we explored the organometallic-mediated radical copolymerization of NVA and vinyl acetate. The optimized polymerization conditions and the comonomer reactivity ratios will be presented. Further conversion of the pendent amides and esters moieties into amino and hydroxy groups, respectively, was also considered for the preparation of unprecedented hydrophilic polyvinylamine-based copolymers. [less ▲]

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See detailSimple, cheap but highly efficient organo catalysts for the fixation of CO2 on propargylic alcohols
Ngassam Tounzoua, Charlene Gabriela ULiege; Gilbert, Bernard ULiege; Detrembleur, Christophe ULiege et al

Poster (2017, May 04)

In the last years, many efforts have been devoted to the valorisation of CO2 as an abundant and renewable C1 building block for cyclic carbonate synthesis. Many synthetic routes have been proposed to ... [more ▼]

In the last years, many efforts have been devoted to the valorisation of CO2 as an abundant and renewable C1 building block for cyclic carbonate synthesis. Many synthetic routes have been proposed to convert CO2 into five or six-membered cyclic carbonates finding applications as green solvent, electrolytes for Li-ion batteries, intermediates for organic synthesis, monomers for the production of polycarbonates or isocyanate-free synthesis of poly(hydroxyrethane)s, etc. Although the 100% atom economy synthesis of 5-membered cyclic carbonates from CO2 and epoxides/oxetanes has been widely reported in the literature, the carboxylative coupling of CO2 with alkynols remains unexplored. Transition metal-based complexes, organic bases (guanidine, amidine, phosphine), N-heterocyclic carbenes or olefins, and K2CO3 have been proposed as catalysts. However they generally present sufficient activity at high pressure and/or temperature or require a high catalyst loading. Additionally some of them are toxic and/or sensitive to hydrolysis or oxidation. In this work, we designed novel, cheap, easily customizable and highly efficient organocatalysts for the synthesis of cyclic α-methylene carbonates from CO2 and alkynols. Kinetics of the CO2/alkynol coupling reaction were followed by Raman spectroscopy with organocatalysts of different structures, and the best candidate was identified. The main parameters that influenced the system reactivity and selectivity have been identified and will be presented in this poster. [less ▲]

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See detailHow to exploit bio- and CO2-based isocyanates-free polyurethanes for environmental and biomedical applications?
Gennen, Sandro ULiege; Grignard, Bruno ULiege; Alves, Margot et al

Poster (2017, May 04)

Polyurethane (PU) is one of the most important family of polymers that is largely used in coatings, foams, elastomers, sealants/adhesives in the building, automotive, household and biomedical sectors ... [more ▼]

Polyurethane (PU) is one of the most important family of polymers that is largely used in coatings, foams, elastomers, sealants/adhesives in the building, automotive, household and biomedical sectors. Classically, PU is produced by a step-growth polymerization between di- or polyols and di- or polyisocyanates. However, isocyanates are toxic and produced from even more toxic phosgene. To avoid the use of isocyanates, different synthetic alternatives for PUs have been developed. One of the most studied approaches relies on the step-growth polymerization between di- or polyamines and CO2-sourced di- or polycyclic carbonates, affording poly(β-hydroxyurethane)s (PHUs) that showed improved thermal, chemical and mechanical properties compared to conventional PUs. In this study, we would like to show how PHUs can be exploited to design (bio- and) CO2-based foams for thermal insulation as well as novel reinforced hydrogels for potential biomedical applications. First, we developed a highly efficient binary organocatalyst for the fast and selective synthesis of cyclic carbonates under very mild conditions from CO2 and various epoxides, including bio-based ones. Secondly, these cyclic carbonates were valorised as monomers for the preparation of foams and hydrogels based on PHUs. In this poster, we will describe the preparation and characterization of these PHU foams and hydrogels, and highlight their huge potential as thermal insulating materials (PHU foams) or as biomaterials for shock absorption properties (PHU hydrogels). [less ▲]

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See detailSAFIR: a software for modeling structures in fire
Franssen, Jean-Marc ULiege; Gernay, Thomas ULiege

Poster (2017, May 02)

SAFIR is a computer program developed at University of Liege to model the behavior of building structures subjected to fire.

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See detailHybrid Fire Testing: A new approach for fire labs
Sauca, Ana ULiege; Gernay, Thomas ULiege; Mergny, Elke ULiege et al

Poster (2017, May 02)

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See detailTrace elements and organochlorines in sperm whales stranded on the coast of Schleswig Holstein in 2016
Pinzone, Marianna ULiege; Schnitzler, Joseph ULiege; Thomé, Jean-Pierre ULiege et al

Poster (2017, May 02)

Several strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled after their discovery on German coasts of Schleswig Holstein ... [more ▼]

Several strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled after their discovery on German coasts of Schleswig Holstein. Muscle, liver, kidney and blubber samples were taken from all specimens for toxicological analyses. The concentrations of lipophilic organic pollutants such as polychlorinated biphenyl (PCB) and pesticides such as DDT were determined in adipose tissue. Metals and trace elements such as cadmium, selenium and mercury were measured in the liver, kidney and muscle. Polychlorinated biphenyls (PCBs) and pesticides such as DDTs were determined in adipose tissue at levels of 0.9 and 1.3 mg.kg-1 lipid weight respectively. Cadmium, selenium and mercury were measured in the liver at respective concentrations of 57, 52 and 81 mg.kg-1 dry weight. The investigated 12 sperm whales stranded on the coasts of Schleswig Holstein in spring 2016 showed a lower contamination of organic pollutants than the 7 sperm whales stranded along the Belgian and Dutch coast in the winter of 1994/95. These animals were clearly larger and older than the ones that stranded in Schleswig-Holstein. So, lower contaminant burden may be due to shorter life span. It seems unlikely that contamination is the direct cause of the death of sperm whales. However, debilitating role of pollutants cannot be excluded, as strandings are often a multi factorial event. Further investigations on the contaminant patterns among the 30 sperm whales at different stranding sites may also give indications on the feeding strategy and linkage among the individuals. [less ▲]

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See detailWal-e-Cities
Schelings, Clémentine ULiege; Reiter, Sigrid ULiege; Teller, Jacques ULiege et al

Poster (2017, May 02)

L’objectif du portefeuille FEDER Wal-e-Cities est le développement de villes intelligentes («Smart Cities») au sein d’un territoire wallon interconnecté. La technologie, vue ici comme un outil au service ... [more ▼]

L’objectif du portefeuille FEDER Wal-e-Cities est le développement de villes intelligentes («Smart Cities») au sein d’un territoire wallon interconnecté. La technologie, vue ici comme un outil au service de la Smart Région Wallonne et de ses citoyens, permettra de répondre à cinq défis principaux identifiés: connectivité, mobilité, énergie et environnement, gouvernance et enfin bien-être en environnement urbain. Les partenaires de ce portefeuille (Universités et Centres de Recherche), et parmi eux l’UR Urban & Environmental Engineering de l'Ulg, oeuvreront au déploiement de solutions dédiées en regard des besoins spécifiques (géographiques, démographiques, socio-économiques et culturels) de chaque ville pilote partenaire. [less ▲]

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See detailGPR101 orphan GPCR: a novel cause of growth hormone deregulation
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine ULiege et al

Poster (2017, May)

GPR101 is an orphan G-protein coupled receptor with unknown ligand. In 2014, an international study clearly pointed to a strong association between this receptor and the X-linked acrogigantism (X-LAG ... [more ▼]

GPR101 is an orphan G-protein coupled receptor with unknown ligand. In 2014, an international study clearly pointed to a strong association between this receptor and the X-linked acrogigantism (X-LAG) syndrome, which begins in childhood and causes the “tallest giants”. The children (carriers of the GPR101 duplication on the X chromosome) grow abnormally even before they are one year old, secrete phenomenal quantities of growth hormone, and develop pituitary adenomas that do not respond to current therapies. The mechanism by which GPR101 contributes to increased growth hormone secretion is currently not known. Nevertheless, the lack of mechanistic insight into the function of GPR101 precludes its validation as a drug target. This lack of knowledge on GPR101 is the consequence of the paucity of specific pharmacological/research tools currently available. Therefore, we propose to study GPR101 functions and its role in growth hormone regulation. First, we determined the receptor cellular localization. We also deciphered its constitutive signalling pathways by detecting high cAMP levels. We completed our study with an examination of receptor coupling to other pathways and G proteins. Furthermore, we applied targeted mutagenesis to modulate the receptor constitutive activity in order to understand the receptor function at a molecular level. These GPR101 mutants will help us to understand the role of this receptor in GH regulation and/or to treat people suffering from pituitary dysfunction. This information is an absolute prerequisite to link molecular pharmacology of GPR101 with physiological functions. [less ▲]

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See detailGBM cells from the tumour mass versus the subventricular zone: molecular and functional characterisation
Di Gregorio, Marina ULiege; willems, Estelle; Dedobbeleer, Matthias ULiege et al

Poster (2017, May)

Life expectancy after diagnosis of glioblastoma (GBM) remains poor even with the best available treatment. This catastrophic survival is the direct consequence of systematic tumour recurrence. It has ... [more ▼]

Life expectancy after diagnosis of glioblastoma (GBM) remains poor even with the best available treatment. This catastrophic survival is the direct consequence of systematic tumour recurrence. It has previously been demonstrated that the subventricular zone (SVZ, a neurogenic niche of the adult central nervous system) attracts and harbours GBM cells, expressing stem cell biomarkers that act like glioblastoma-initiating cells. These cells hosted in the SVZ may be responsible for tumour recurrence. To better understand the difference between cells from the tumour mass (TM) and those migrating to the SVZ, this project will focus on two axes. First, a proteomic and transcriptomic approach will be used to identify one or more biomarkers that might help to establish if recurrences originate from the TM or the SVZ. The second aim of the project is to compare these two populations of cells from a functional point of view. Some functional differences have already been observed: cells derived from SVZ form more spheroids than those derived from TM (1). U87MG cells from SVZ also form tumours more easily in mice compared to cells derived from the TM (2). However, preliminary results in chemo- and radioresistance assays on the cultured cells (U87MG) do not show significant differences between the two populations. Therefore, it might be the SVZ environment that plays a key role in therapeutic resistance, rather than intrinsic biological differences of cells from the TM versus the SVZ. [less ▲]

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See detailEcomorphology of the axial skeleton in Odontocetes and Mysticetes
Gillet, Amandine ULiege; Parmentier, Eric ULiege

Poster (2017, May)

Ecomorphology concerns the study of the relationships between functional design and the environmental constraints acting on organisms. It aims to understand how the morphological variations among species ... [more ▼]

Ecomorphology concerns the study of the relationships between functional design and the environmental constraints acting on organisms. It aims to understand how the morphological variations among species can be related to environmental factors and impact fitness. Having a large diversity both in their morphology and ecology, the cetacean taxa appears to be the ideal taxa to tackle the relationships between the locomotor system and way of life. Different studies have already showed that the number and shape of vertebrae in different cetaceans can reflect the stiffness of the body and consequently can impact their swimming mode. The aim of this study is to establish relationships between characteristics of the vertebral column of different cetaceans and their ecology. Meristic and morphometric data were collected on the vertebrae (centrum lengths, heights and widths, neural spine heights and transverse processes lengths) of species of odontocetes housed in different Natural History Museums in the world (AM-ULg, RBINS, MNHN, SMNS, NRM, Queensland, PEM, Iziko). Preliminary results show clear morphological variations between species at the level of the number and sizes of vertebrae. There is a clear relationship between body size and number of vertebrae except in Delphinidae. This family has an important higher vertebral count. These differences should be related to different swimming modes and reflect the different ecological behaviours of the studied cetaceans. [less ▲]

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See detailTreatment MEthodology and MOnitoring for sequenced Reallocation of severely polluted Industrial Sites (MEMORIS) project
Duprez, Marie-Eve; Castro, Cristiana; Devalckeneer, Aude et al

Poster (2017, May)

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See detailA surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
Farhat, Khalil ULiege; Bodart, Gwennaëlle ULiege; Renard, chantal et al

Poster (2017, May)

In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a ... [more ▼]

In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a consensus about GH immunomodulatory properties. These studies investigated the immune and anti-infectious response of dwarf Ghrh-/- mice presenting a severe deficiency of the GHRH/GH/IGF-1 axis. In basal conditions, thymic parameters and T-cell responses of Ghrh-/- mice were not severely affected but a constant B-cell lymphopaenia was observed. Thus, we investigated vaccine and anti-infectious responses of Ghrh-/- mice toward Streptococcus pneumonia, a B-dependent pathogen, Ghrh-/- mice were unable to trigger production of specific IgM and IgG against serotype 1 pneumococcal polysaccharide (PPS) after vaccination with either native PPS (Pnx23) or protein-PPS conjugate (Prev-13) vaccines. These vaccines both include the serotype 1 (our S.pneumoniae strain) and provide an effective protection in mice. A short GH supplementation to Ghrh-/- mice (1 daily injection of 1 mg/kg GH for 4 weeks) restored IgM and IgG response to Pnx23 vaccine but not to Prev-13. This suggests that GH could exert distinct impacts upon spenic areas. Furthermore, after intranasal instillation of a non-lethal dose (defined by the full clearance by WT C57BL/6 mice after 24h) of serotype 1 S.pneumoniae, Ghrh-/- mice exhibited a dramatic susceptibility. This was proved by a marked time-dependent increase in pulmonary bacterial, a septicemia already 24h after infection and a survival limit of 72h. We also observed a dramatic decrease in lung B- and T-cell populations and an increase in proportion of inflammatory macrophages. By contrast, wild-type and heterozygote mice completely cleared S.pneumoniae infection after 24h. In conclusion, our data show without ambiguity that the somatotrope GHRH/GH/IGF-1 axis plays an important and unsuspected role in defense against S.Pneumoniae. [less ▲]

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See detailSalmonella thyphimirium early onset neonatal sepsis
Thirion, Sophie ULiege; RIGO, Vincent ULiege; Snyers, Diane ULiege et al

Poster (2017, May)

Background: Early onset neonatal sepsis due to salmonella spp is rare in developed countries. Vertical and horizontal transmissions were described, including faecal contamination of the birth canal. After ... [more ▼]

Background: Early onset neonatal sepsis due to salmonella spp is rare in developed countries. Vertical and horizontal transmissions were described, including faecal contamination of the birth canal. After a short incubation period, newborns may remain asymptomatic or present with sepsis or meningitis. Mortality rate as high as 58% were reported. Case Presentation Summary: We report a case of transplacental Salmonella Typhimurium infection in a premature infant. A mother with a one day history of fever and diarrhoea spontaneously delivered a premature boy at 35 weeks of gestation. On day 3, the infant presented with symptoms suggesting necrotizing enterocolitis: apnea, respiratory distress, feeding intolerance, bloody diarrhea and fever. Feeding were suspended and intravenous antibiotic therapy (ampicillin, amikacine and metronidazole) initiated. Laboratory data showed an inflammatory syndrome with elevated C-reactive proteine (71 mg/l), leukocytopenia (7270/mm3) and severe lymphopenia (580/mm3). Enterocolitis stage 1 (Bell classification) was diagnosed based on clinical and radiological evaluation. Salmonella spp were grown from the baby’s blood and stools and from the mother’s stools; the National Reference Center identified a Salmonella Typhimurium. Cerebrospinal fluid culture remained sterile. Clinical and biological evolutions were rapidly favourable with 14-days of cefotaxim IV. Maternal history revealed consumption of raw meat 3 days before delivery.Learning Points/Discussion: Salmonella spp should be considered in the differential diagnosis of early onset sepsis, particularly when mother presents gastrointestinal symptoms. Food safety education is crucial. The consumption of raw or uncooked meat during pregnancy should be avoided regardless toxoplasmosis immunization status. To avoid outbreaks in the neonatal ward (as reported in the literature), rapid detection and prompt institution of isolation and clustering measures are important. [less ▲]

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See detailIs Young Adolescents’ Self-Esteem Predicted by Peer Acceptance? A Gender Perspective
Gaudet, Olivier; Vollet, Justin; Véronneau, Marie-Hélène et al

Poster (2017, May)

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See detailDeciphering the role of dendritic sodium channels on action potential dynamics in substantia nigra dopaminergic neurons
Moubarak, Estelle; Engel, Dominique ULiege; Dufour, Martial et al

Poster (2017, May)

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See detailSniffing Out the Hypoxia Volatile Metabolic Signature of Aspergillus fumigatus
Stefanuto, Pierre-Hugues ULiege; Rees, Christiaan A.; Beattie, Sarah R. et al

Poster (2017, May)

Background: Aspergillus fumigatus is responsible for the life-threatening infection invasive aspergillosis (IA) that is associated with high mortality in immunocompromised individuals. Current diagnostics ... [more ▼]

Background: Aspergillus fumigatus is responsible for the life-threatening infection invasive aspergillosis (IA) that is associated with high mortality in immunocompromised individuals. Current diagnostics for IA are either highly invasive or suffer from inadequate sensitivity and/or specificity. Improvement of IA diagnostic assays requires a better understanding of fungal metabolism inside the host. The infection microenvironment becomes progressively depleted of oxygen during IA. Thus, metabolites associated with hypoxia metabolism may yield to novel diagnostic biomarkers. Here, we report on the volatile metabolites emitted from A. fumigatus batch cultures under normoxia and hypoxia conditions. Methods: A. fumigatus strain CEA10 was incubated in glucose minimal medium at 37 °C under either normoxia (21% O2, 0.04% CO2) or hypoxia (0.2% O2, 5% CO2) growth conditions. Volatile molecules from the supernatants of early (1 h) and late (8 h) cultures were collected using headspace solid-phase microextraction (HS-SPME) and analyzed using two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS). Results: We identified 10 volatile compounds that are significantly more abundant in late hypoxia cultures compared with all other experimental conditions. Among these compounds, we identified ethanol and acetaldehyde, which are known to result from hypoxia metabolism of glucose by A. fumigatus. In addition, we detected 2-propanol, which can be generated by the reduction of acetone via alcohol dehydrogenase, as well as 2,3-butanedione (diacetyl) and 3-hydroxy-2-butanone (acetoin), which results from the catabolism of acetolactate. Transcriptomic data collected from normoxia and hypoxia cultures validates our volatilomic findings through the identification of putative catabolic pathways that are upregulated during hypoxia growth. Diacetyl is known to be produced by bacteria as a pH-neutral fermentative byproduct to prevent lethal acidification, and we speculate that A. fumigatus may use the same pathway. Conclusion: The composition of A. fumigatus’ volatile metabolome changes according to the oxygen tension in the environment. We measured hypoxia-associated compounds, ethanol and acetaldehyde which have been previously identified as byproducts of hypoxia metabolism in this organism. 2-propanol, 2, 3-butanedione and 3-hydroxy-2-butanone represent novel metabolites that suggests the existence of other catabolic pathways activated in A. fumigatus under hypoxia growth conditions. [less ▲]

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See detailL’hospitalisation sous contrainte : Urgences psychiatriques et mises en observation.
Schmits, Emilie ULiege; Evrard, Maude; Valassopoulou, Eftychia et al

Poster (2017, May)

Detailed reference viewed: 25 (2 ULiège)
See detailBasic Helix loop Helix transcription factor twist1a and twist1b and their involvement in the skeletal development of zebrafish.
Zappia, Jérémie ULiege; Windhausen, Thomas ULiege; Renn, Jörg ULiege et al

Poster (2017, May)

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to ... [more ▼]

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to be mutated in cases of the Saethre–Chotzen syndrome (SCS). However, the roles of these genes in skeletal development in zebrafish remain to be clarified. The aim of our research is to characterize the effects of the knock-down of twist1a and twist1b in the zebrafish. 2. Methods Antisens morpholino are used for the knock-down of twist1a and twist1b (respectively MoTwist1a and MoTwist1b). The sox9a expression is investigated using whole amount in situ hybridization. 3. Results We show the spatio-temporal expression pattern of twist1a and twist1b during the first 6 days of zebrafish development and present the effects observed on cartilage and bone formation upon knock-down of these genes in zebrafish larvae. The results reveal a decrease of the cranial cartilage and bone formation in both MoTwist1a and MoTwist1b. Interestingly, when MoTwist1a and MoTwist1b are co-injected, the cranial cartilage formation is strongly reduced, while ectopic cartilage formation appeared in the front of the head. We also show an increase in expression of sox9a, a master regulator of chondrogenesis, in morphants. 4. Summary and Conclusions Even though it was shown that twist1a and twist1b maintain a pool of osteoprogenitor-like cells, we show that a knock-down of these genes induces a decrease of skeletal formation. Our hypothesis is that the morphants run out of progenitor cells to assure correct bone and cartilage formation. In the future, we plan to generate twist1a mutants in order to further characterize the effect of this mutation. The twist1a mutant will eventually serve for a rescue study using human TWIST1 mRNA, wild-type or mutant in order to have a better understanding of the human disorder SCS. [less ▲]

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See detailInvestigation of the glycolytic switch induced by saturated fatty acid in human macrophages
Colonval, Megan ULiege; Fettweis, Grégory; L'homme, Laurent et al

Poster (2017, May)

Detailed reference viewed: 23 (2 ULiège)
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See detailMCDHF calculations of isotope shifts in neutral antimony
Gamrath, S.; Palmeri, P.; Quinet, Pascal ULiege et al

Poster (2017, May)

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See detailInfluence qualitative et quantitative du mode de séchage sur l'huile essentielle de Thymus fontanesii de l'Algérie
Sidali, Lamia; Brada, Moussa; Fauconnier, Marie-Laure ULiege et al

Poster (2017, May)

Cette étude a pour but d`étudier l`influence du mode de séchage (à l’ombre et au soleil) sur le rendement et la composition chimique de l`huile essentielle de Thymus fontanesii de l`Algérie obtenue par ... [more ▼]

Cette étude a pour but d`étudier l`influence du mode de séchage (à l’ombre et au soleil) sur le rendement et la composition chimique de l`huile essentielle de Thymus fontanesii de l`Algérie obtenue par extraction assistée par induction électromagnétique. Les résultats ont montré que le séchage à l`ombre a donné un meilleur rendement de (1.12%) après une période de séchage de 10 jours jusqu`à la stabilisation de teneur en eau, alors que le séchage au soleil pendant 8 jours donne un rendement de (0.89%). La composition chimique de l`huile essentielle de Thymus fontanesii (TF) a été analysé par la chromatographie en phase gazeuse couplée à la spectrométrie de masse (GC/MS) et la chromatographie en phase gazeuse a ionisation de flamme (GC/FID). [less ▲]

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See detailNew identification of energy levels in the astatine atom, the rarest element on Earth
Quinet, Pascal ULiege; Sicorello, G.

Poster (2017, May)

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See detailPlasma effects on the atomic structure and X-ray lines of astrophysical interest in oxygen ions
Deprince, J.; Palmeri, P.; Quinet, Pascal ULiege et al

Poster (2017, May)

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See detailTranscriptome wide analysis of natural antisense transcripts shows potential role in breast cancer
Wenric, Stéphane ULiege; El Guendi, Sonia; CABERG, Jean-Hubert ULiege et al

Poster (2017, May)

Non-coding RNAs (ncRNA) represent at least 1/5 of the mammalian transcript amount, and about 90% of the genome length is actively transcribed. Many ncRNAs have been demonstrated to play a role in cancer ... [more ▼]

Non-coding RNAs (ncRNA) represent at least 1/5 of the mammalian transcript amount, and about 90% of the genome length is actively transcribed. Many ncRNAs have been demonstrated to play a role in cancer. Among them, natural antisense transcripts (NAT) are RNA sequences which are complementary and overlapping to those of protein-coding transcripts (PCT). NATs were punctually described as regulating gene expression, and are expected to act more frequently in cis than other ncRNAs that commonly function in trans. In this work, 22 breast cancers expressing estrogen receptors and their paired healthy tissues were analyzed by strand-specific RNA sequencing. To highlight the potential role of NATs in gene regulations occurring in breast cancer, three different gene extraction methods were used: differential expression analysis of NATs between tumor and healthy tissues, differential correlation analysis of paired NAT/PCT between tumor and healthy tissues, and NAT/PCT read count ratio variation between tumor and healthy tissues. Each of these methods yielded lists of NAT/PCT pairs that were demonstrated to be enriched in survival-associated genes on an independent cohort (TCGA). This work allows to highlight NAT lists that display a strong potential to affect the expression of genes involved in the breast cancer pathology. [less ▲]

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See detailIdentifying infectious agents from lung transplant patients using GC×GC-TOFMS
Stefanuto, Pierre-Hugues ULiege; Rees, Christiaan A.; Romamno, Rosalba et al

Poster (2017, May)

During the first year post-surgery, bacterial and fungal infections are the main causes of death in lung transplant recipients. Contributing substantially to the high mortality rate (35%) is the lengthy ... [more ▼]

During the first year post-surgery, bacterial and fungal infections are the main causes of death in lung transplant recipients. Contributing substantially to the high mortality rate (35%) is the lengthy time-to-diagnosis, which includes both pathogen identification and antibiotic resistance profiling. A novel diagnostic strategy based on the detection of volatile compounds in breath seems a promising option to improve these patients’ outcomes. In order to demonstrate the feasibility of this approach, we characterized the volatile fraction of different clinical matrices (i.e., bronchoalveolar lavage (BAL) and blind bronchial aspirate (BBA)). Due to the complexity of the mixture and high dynamic range of the concentrations, we applied headspace solid phase microextraction (HS-SPME) combined with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOFMS) to obtain a comprehensive overview of the sample headspace composition. Following the analytical step, we applied various univariate and multivariate statistical methods (e.g. random forest, principal component analysis, and hierarchical cluster analysis) in order to extract required information from the data. Based on the composition of the volatile fraction, we were able to differentiate between BAL and BBA with a classification accuracy of 88.4 %. Furthermore, we could correctly distinguish between individuals with active respiratory infections and those without infection with a 72.2 % classification accuracy. In some cases, it was also possible to differentiate between pathogens at the species level. These results are preliminary evidence to suggest the possibility of detecting infections in these patient without the use of time-consuming culture techniques. [less ▲]

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See detailNew models for predicting microcarrier just-suspended state in bioreactors
Loubière, Céline; Olmos, Eric; Guedon, Emmanuel et al

Poster (2017, May)

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See detailComparison of rapid protein structure determination approaches driven by experimental NMR data
Wanko Nembot, Alexis Marius ULiege

Poster (2017, May)

The knowledge of the tridimensional structure of a protein is essential to design drugs, to predict protein function and to study mechanism of protein function. 3D structure can be determined using two ... [more ▼]

The knowledge of the tridimensional structure of a protein is essential to design drugs, to predict protein function and to study mechanism of protein function. 3D structure can be determined using two experimental techniques: X-Ray and NMR. However, these techniques have limitations: they are time consuming, manually intensive and sometime technically difficult. Due to these limitations, different approaches that combine the strength of computer and sparse experimental NMR data have been proposed to determine rapidly 3D protein structure. Thus different approaches that use sparse NMR experimental NMR data such as backbone chemical shifts, incomplete sets of NOEs distances and residual dipolar couplings of backbone have been designed. To assess whether if these automated methods can indeed produce structures that closely match those manually refined by experts using the same experimental data, Critical Assessment of Automated Structure Determination of Proteins from NMR Data [1] (CASD-NMR) was created. CASD-NMR concept closely resembles to Critical Assessment of Automated Structure Prediction [2] (CASP) that aim to assess performance of protein structure prediction methods from sequence. Accordingly to CASD-NMR 2013 [3] recommandations, we are working on the comparison of different automated protein structure determination methods driven by backbone chemical shifts and homology modeling in terms of the fitness of resulting 3D structures with experimental NMR data. For homology modeling, we have been using two approaches: I-TASSER [4] and MODELLER [5] that are best public CASP-certified protein structure prediction servers. Structure calculation guided by NMR backbone chemical shifts were done using different approaches: (i) ROSETTA method that is widely used by the scientific community. Different rosetta based methods exist that used only backbone chemical shifts as experimental data. Moreover, ROSETTA method is probably the most backbone chemical shifts based structure calculation method used and cited by the community. For our comparison, three ROSETTA-family methods have been used: CS-ROSETTA [6], CS-HM-ROSETTA [7] and RASREC CS-ROSETTA [8]. (ii) Cheshire which is the first backbone chemical shifts based method which performed as well as CS-HM-ROSETTA during CASD-NMR-2013, and (iii) CS23D which is a web server that performed 1000-10,000 times faster than competing methods (Cheshire [9] and CS-Rosetta). Each of these approaches were used to determine 3D structure of a benchmark of 50 proteins. These 50 proteins were randomly selected within proteins for which NMR backbone chemical shifts are available in the BMRB data bank excluding proteins that have been used during CASD or CASP. In addition, we will applied these methods on cold shock proteins for which we have our own experimental data. [less ▲]

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See detailL'enseignement-apprentissage du français dans le qualifiant : regards croisés
Scheepers, Caroline ULiege; Outers, Pierre ULiege; Werner, Anne-Catherine ULiege

Poster (2017, April 29)

La présentation donne à voir les résultats partiels d'une recherche exploratoire qui a consisté à questionner les élèves et les professeurs de l'enseignement secondaire de transition et du qualifiant à ... [more ▼]

La présentation donne à voir les résultats partiels d'une recherche exploratoire qui a consisté à questionner les élèves et les professeurs de l'enseignement secondaire de transition et du qualifiant à propos de leurs représentations relatives à l'enseignement-apprentissage du français dans le qualifiant. Pour l'heure, nous disposons des réponses apportées par 30 enseignants et par 450 élèves. A terme, cinquante enseignants et 1000 élèves sont concernés. [less ▲]

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See detailGrazing-induced BVOC fluxes from a managed grassland
Mozaffar, Ahsan ULiege; Schoon, N.; Bachy, Aurélie ULiege et al

Poster (2017, April 28)

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See detailN2O eddy covariance fluxes : from field measurements to flux analysis
Lognoul, Margaux ULiege; Debacq, Alain ULiege; Heinesch, Bernard ULiege et al

Poster (2017, April 28)

N2O eddy covariance data were collected for a complete season of sugar beet crop (from first fertilization to harvest). Data treatment and preliminary results are presented.

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See detailThree-dimensional modelling of the hydrodynamics of the Southern Bight of the North Sea: first results
Ivanov, Evgeny ULiege; Capet, Arthur ULiege; Barth, Alexander ULiege et al

Poster (2017, April 28)

In the frame of the Belgian research project FaCE-It (Functional biodiversity in a Changing sedimentary Environment: Implications for biogeochemistry and food webs in a managerial setting), the impact of ... [more ▼]

In the frame of the Belgian research project FaCE-It (Functional biodiversity in a Changing sedimentary Environment: Implications for biogeochemistry and food webs in a managerial setting), the impact of dredging activities andoffshorewindfarminstallationonthespatialdistributionofsedimentgrainsize,biodiversityandbiogeochemistry will be estimated in the Southern Bight of the North Sea (SBNS) with a focus on the Belgian Coastal Zone (BCZ). To reach this goal, the three-dimensional hydrodynamical model ROMS-COAWST is implemented in the SBNS in order to simulate the complex hydrodynamics and sediment transport. Two levels of nesting are used to reach a resolutionof250mintheBCZ.Themodelisforcedattheair-seainterfacebythe6-hourlyECMWFERA-interim atmospheric dataset and at the open boundaries by the coarse resolution model results available from CMEMS (Copernicus Marine Environment Monitoring Service), and also considers tides and 4 main rivers (Scheldt, Rhine with Maas, Thames and Seine). Two types of simulations have been performed: a 10-years climatological simulation and a simulation over 20032013toinvestigatetheinterannualdynamics.Themodelskillsareevaluatedbycomparingitsoutputstohistorical data (e.g. salinity, temperature and currents) from remote sensing and in-situ. The sediment transport module will then be implemented and its outputs compared to historical and newly collected (in the frame of FaCE-iT) observations on grain size distribution as well as with satellite Suspended Particulate Matter (SPM) images. This will allow assessing the impact of substrate modification due to offshore human activities at local and regional scales. [less ▲]

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See detailLa place des genres textuels dans la perspective actionnelle des langues étrangères
Simons, Germain ULiege; Delbrassine, Daniel ULiege

Poster (2017, April 28)

Voir poster en fichier attaché

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See detailDoes tree species richness attenuate the effect of experimental irrigation and drought on decomposition rate in young plantation forests?
Rahman, Md Masudur ULiege; Verheyen, Kris; Castagneyrol, Bastien et al

Poster (2017, April 27)

Expected changes in precipitation in Europe due to climate change are likely to affect soil organic matter (OM) transformation. In forests, increasing tree species diversity might modulate the effect of ... [more ▼]

Expected changes in precipitation in Europe due to climate change are likely to affect soil organic matter (OM) transformation. In forests, increasing tree species diversity might modulate the effect of changed precipitation. We evaluated the effect of tree species richness on the decomposition and stabilization rate in combination with reduced precipitation (FORBIO, Belgium) and irrigation treatment (ORPHEE, southern France) in young (6-8 yr.) experimental plantations. The species richness were one to four in FORBIO and one to five in ORPHEE. Twenty four rainout shelters of 3 m × 3 m were built around oak and beech trees in FORBIO plantation to impose a reduced precipitation treatment, whereas four of the eight blocks (175 m×100 m) in ORPHEE plantation was subjected to irrigation treatment. These treatments resulted in about 4% less soil moisture in FORBIO and about 7% higher soil moisture in ORPHEE compared to control. Commercially available green and rooibos tea bags were buried in the soil at 5-7 cm depth to measure two decomposition indices, known as ‘tea bag index’ (TBI). These TBI are (i) decomposition rate (k) and (ii) stabilization rate (S). The results showed no species richness effect on TBI indices in both reduced precipitation and irrigation treatment. In FORBIO, reduced precipitation resulted in decreased k and increased S compared to control around the beech trees only. In ORPHEE, both k and S were higher in the irrigation treatment compared to control. Overall, TBI indices were higher in FORBIO than ORPHEE and this might be explained by the sandy soils and poor nutrient content at the ORPHEE site. These results suggest that OM decomposition rate may be slower in drier condition and OM stabilization rate may be slower or faster in drier condition, depending on the site quality. The absence of tree species effects on OM transformation indicates that tree species richness would not be able to modulate the effects of changed precipitation patterns in young plantations. We conclude that in young afforestations, soil moisture has more influence on OM transformation than tree species richness. [less ▲]

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See detailCARACTERISATION BIOCHIMIQUE DES AMANDES DE QUELQUES VARIETES D’AMANDIER EN CULTURE DANS LA REGION ORIENTALE DU MAROC
Melhaoui, Reda; Houmy, Nadia ULiege; Ben Moumen, A et al

Poster (2017, April 27)

Le Plan Maroc Vert (PMV) accorde une grande importance à l’agriculture solidaire en faveur des zones agro écologiques fragiles. Dans ce cadre on assiste dans la région orientale du Maroc à l’extension des ... [more ▼]

Le Plan Maroc Vert (PMV) accorde une grande importance à l’agriculture solidaire en faveur des zones agro écologiques fragiles. Dans ce cadre on assiste dans la région orientale du Maroc à l’extension des plantations d’amandier, au dépend des cultures annuelles, jugées non rentable et étroitement lié à la pluviométrie. Ainsi le projet*PROFAO porte sur la plantation de 6000 ha de nouveaux vergers d’amandier, avec principalement les variétés Ferragnes et Ferraduel (F/F) en raison de leur floraison tardive en Mars, qui leur permet d’échapper aux effets néfastes des gelées de Janvier et Février. Dans un but de la diversité des cultures et de la sauvegarde de la biodiversité et également dans un but de valorisation en post récolte des amandes et produits dérivés. Cette étude porte sur la caractérisation de variété(s) locale(s), nommée «Amandier Beldi (Be)» à floraison précoce et qui semble être une variété population. La comparaison aux variétés F/F, porte sur des caractères botaniques et la période de floraison et surtout sur la composition chimique des amandes comme produits final de la récolte. A ce propos «Be» fleurissent dès le début février alors que pour F/F la floraison est pour Mars. Les analyses des huiles et tourteaux d’amandes des récoltes antécédentes, montent un rendement moyen en huile, de l’ordre de 50% pour «Be» et de 57% pour «F/F» avec des profils d’acide gras comparables. L’analyse des tourteaux ne montre pas de différences significatives ainsi on observe, pour« Be » des teneurs en protéines de 47% et en sucres de 14,2% et pour l’association F/F ces teneurs sont respectivement de 45% et 13% [less ▲]

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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

Poster (2017, April 27)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

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See detailHighlights from two years of remote sensing at Mars with MAVEN’s Imaging Ultraviolet Spectrograph
Chaffin; Schneider; Deighan et al

Poster (2017, April 27)

The Mars Atmosphere and Volatile EvolutioN (MAVEN) mission’s Imaging Ultraviolet Spectrograph (IUVS) observes Mars in the far and mid ultraviolet (110-340 nm), investigating lower and upper atmospheric ... [more ▼]

The Mars Atmosphere and Volatile EvolutioN (MAVEN) mission’s Imaging Ultraviolet Spectrograph (IUVS) observes Mars in the far and mid ultraviolet (110-340 nm), investigating lower and upper atmospheric structure and indirectly probing neutral atmospheric escape. After two Earth years in orbit (one Mars year), IUVS has assembled a large quantity of data and made many discoveries, some of which we report here. Among the key results obtained by IUVS are: (1) discovery of the widespread occurrence of a diffuse proton aurora, representing a newly discovered means of energy deposition into the atmospheres of unmagnetized planets; (2) continued investigation of time-variability in H and O escape, which have dessicated the planet over its history; and (3) synoptic characterization of thermospheric variability and response to solar input. We will present an overview of these results and a discussion of their implications for the state of the atmosphere and its evolution. [less ▲]

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See detailHybrid places : a conceptual framework
Uyttebrouck, Constance ULiege; Teller, Jacques ULiege

Poster (2017, April 27)

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See detailImportin-8 could cause CAE/JME by delaying early neuroblast migration
Nganou, Gerry ULiege; Tanaka, Miyabi; Coumans, Bernard ULiege et al

Poster (2017, April 27)

Abstract : Childhood Absence Evolving to Juvenile Myoclonic Epilepsy (CAE/JME) is an uncommon form of genetic generalized epilepsy that appears as absence in childhood and evolves into generalized ... [more ▼]

Abstract : Childhood Absence Evolving to Juvenile Myoclonic Epilepsy (CAE/JME) is an uncommon form of genetic generalized epilepsy that appears as absence in childhood and evolves into generalized tonic–clonic seizures with myoclonic jerks during adolescence. In some family of patients affected by CAE/JME, mutations have been observed in the gene encoding for the transport protein importin-8 (IPO8). IPO8 could be at the origin of CAE/JME via its role in the transport of its targets (like Ago-2, Smad4, c-Jun). RT-qPCR has shown that IPO8 mRNA is expressed at all ages with no big difference in expression level. Using ISH, a clear expression of mIPO8 mRNA was observed in the sub-ventricular/ventricular zone (SVZ/VZ), the cortical plate (CP) and the ganglionic eminences (GE) of developing brain at E14. Both SVZ/VZ and GE are the “neurogenic niches” that generate glutamatergic and GABAergic neurons respectively. The implication of IPO8 in the generation of “glutamatergic neurons” was investigated by In Utero electroporation (IUE) and MGE Electroporation. Using shRNA, we observed that after 3 days, “glutamatergic neuroblasts” do not reach the CP in contrast to the control condition. This effect can be rescued by the co-expression of a form of IPO8 that is resistant to the shRNA. When overexpressing the pathological forms of hIPO8, but not a variant, migration of “glutamatergic neuroblasts” was also impaired. However, when the observation is made later, i.e. at P5, we observed that the neuroblasts finally reach their correct layer in the cortex, suggesting IPO8 only delayed but not blocked migration. Moreover, shRNA against IPO8 mRNA lead to alteration of interneurons (GABAergic neurons) migration same to overexpression of one mutated form of IPO8. Conclusion : IPO8 is expressed in mouse brain during development. It shows a clear expression during embryogenesis in the “neurogenic niches”. Moreover, IPO8 modulates neuroblasts (radial and tangential) migration in the developing brain. So, abnormal brain development due to IPO8 mutations could be at the origin of CAE/JME. [less ▲]

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See detailBotanical and Physicochemical characterization of almond population varietal in eastern Morocco
Melhaoui, Reda; Houmy, Nadia ULiege; Mihamou, Atika et al

Poster (2017, April 27)

Abstract: Cooperatives play an important role in socio-economic development. In this regard, the Eastern Morocco adopts this strategy via the PROFAO* Project as a way of promoting local development, which ... [more ▼]

Abstract: Cooperatives play an important role in socio-economic development. In this regard, the Eastern Morocco adopts this strategy via the PROFAO* Project as a way of promoting local development, which guarantees sustainable jobs. This project is based on planting 6000 ha of new almond orchards and creating three cooperatives to value post-harvest Almond products. Currently the Eastern Moroccan regions could benefit of the new project PRD** which will include local Almond varieties characterization to safeguard its biodiversity and the valorization of its products. This study concerns two mains points 1) Botanical characterization of local varieties named "almond Beldi (Be)" based on the flowering period and determination of the color of the flowers 2) Physicochemical characterization of some parameters such as the oil yield, acid and peroxide values. This botanical study shows the result of the early flowering variety (Be) (beginning in February). The color results of 100 flowers analyzed by chromametre , shows two different color categories. The first is very light pink to white (L*=81,58 ; a*=7.43 ;b*=8.06) and the second is a dark pink (L*=71,64 ;a*= 18,34 ;b*= 4,97), with a difference in color between the two categories ∆E=15.07. This almond variety shows an oil yield of 50%, a low acidity value 0,039 (% of Linoleic acid ) and a peroxide value of 16.39 (meq/o2/Kg). [less ▲]

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See detailProfil d'acides gras et acides aminés essentiels de la vainde ovine de la race Beni-Guil conduite en élevage semi-extensif dans l'est du Maroc
Belhaj, Kamal ULiege; Mansouri, Farid; Sindic, Marianne ULiege et al

Poster (2017, April 27)

Les viandes sont commercialisées sous forme de muscles prêts à découper ou de portions « pièces »prêtes à cuire. La couleur de la viande est le premier paramètre de qualité perçue par le consommateur ... [more ▼]

Les viandes sont commercialisées sous forme de muscles prêts à découper ou de portions « pièces »prêtes à cuire. La couleur de la viande est le premier paramètre de qualité perçue par le consommateur, ensuite les paramètres de qualité organoleptiques, hygiénique et nutritionnelle deviennent déterminants et le guide dans son choix. La viande ovine de la race Béni-Guil, qui bénéficie de l’Indication géographique protégée est réputée pour sa qualité gustative et nutritionnelle mais uniquement sur la base de tests hédonique. De ce fait, vient cette étude sur l’analyse de la couleur et des profils lipidiques et protéiques du muscle long dorsal (LDM), un muscle de référence et morceau de viande apprécié par le consommateur. L’analyse de la couleur a montré que LDM de la race béni-guil a une couleur rouge vif très recherché par le consommateur avec un indice de rouge de 14,74. Les résultats d’analyse par GC-FID a permis l’identification de 27 d’acide gras (AG). Comme il a été signalé dans d’autres études (1,2). On observe, qu’un apport de suppléments alimentaires à base d’orge et de son en période critique (sécheresse, ou période de soudure), engendrerait des variations assez importantes par rapport à une conduite au pâturage. En effet, au niveau du profil lipidique le taux d’AG saturés augmente de 40% à 49% au dépend du taux d’AG insaturés qui chute de 60 à 51%. Pour les AG majoritaires, les plus importantes variations ont été enregistrées pour la teneur en acide oléique (C18:1n9) qui chute de 38% à 35%, en faveur de l’acide palmitique (C16:0) qui augmente de 20 à 24%. L’analyse de la composition en acides aminés par HPLC a permis l’identification de 17 acides aminés dont 8 essentiels (His, Mét, Ile, Leu, Lys, Thr, Val, Phe). [less ▲]

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See detailNutritional and organoleptic quality of Beni-Guil lamb meat breeding in eastern Morocco
Belhaj, Kamal ULiege; Mansouri, Farid; Sindic, Marianne ULiege et al

Poster (2017, April 27)

Nowadays in Morocco, 98% of red meat production is ensured by cattles, sheeps and goast. The eastern Morocco represents one of the main sheep farming areas, characterized by the specificity of its ... [more ▼]

Nowadays in Morocco, 98% of red meat production is ensured by cattles, sheeps and goast. The eastern Morocco represents one of the main sheep farming areas, characterized by the specificity of its production systems. So it is well known by the quality of the sheep meat produced. The Beni-Guil breed is a dominate breed in this breeding area, labeled Protected Geographical Indication (PIG). Thus, it’s an important protein source for the population in this geographical site and highly appreciated by consumers. This reputation is limited to the hedonic quality, and there is currently no scientific data available on the organoleptic and nutritional quality of Beni-Guil meat. The objective of this research is to give a scientific point on the nutritional and organoleptic quality of this meat by biochemical analyzes of the major and minor composition of the Longissimus dorsi muscle (LDM). The results of the organoleptic quality analysis show that the meat of Beni-Guil breed has a bright red color, with a chromaticity of 23.97, an a/b ratio of 0.96 and a hue angle of 46.47, Significant juiciness with a water retention capacity and cooking loss of 22.73 and 32.87% respectively, and a marked tenderness with a collagen content of 0.1%. Thus the analysis of nutritional quality showed that LDM of the Beni-Guil has a high nutritional and dietary value, rich in polyunsaturated fatty acid (PUFA) and essential amino acid, with an PUFA/SFA ratio of 0.25, a ratio PUFA n-6/PUFA n-3 of 3.78, and a Protein Digestibility-Corrected Amino Acid score (PDCAAS) of 127. [less ▲]

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See detailInterviews on Residential Building Stock Deep Renovation in Belgium
Ruellan, Guirec ULiege

Poster (2017, April 26)

Belgium should increase the deep renovation rate of existing residential building stock at least to 3% a year to achieve the EU objectives of decreasing by 80% the Green House Gas Emissions before 2050 ... [more ▼]

Belgium should increase the deep renovation rate of existing residential building stock at least to 3% a year to achieve the EU objectives of decreasing by 80% the Green House Gas Emissions before 2050. Since the first thermal legislations (between 1985 and 2000, depending on the Region), efficiency and comfort of newly built houses have met higher standards. But the renovation rate of residential buildings remained stable in the last 20 years. Only 25000 renovation permits are issued each year, in which a small amount of them are highly energy efficient. Literature review has showed that drivers and barriers of deep renovation are many and varied, sometimes contradictory and often underestimated. Conducted interviews with experts who study different facet of renovation present some others viewpoints on this subject. According to their own specific experience, each interviewee thinks differently on possible solutions. The poster set out the interview analysis. Some points are very close to the literature review, such as the environmental and economic issues of the residential renovation, while other results are solely extracted based on the interviews’ results. Amongst others, the necessity to maintain and improve the existing building stock to new standards takes an important place. The regulation appears to be a good driver as much as a barrier, depending on the local legislations and buildings context particularly in Belgium where the diversity of the building stock is very important. Public policies seem to be the first tools to unlock the renovation rate even if the development of new financial model and the information of stakeholders are also highlighted. This analysis increases the comprehension of the renovation topic on a new level, including some adjacent ideas that lead to better understanding of the existing barriers and possible strategies to overtake them, so that to involve everyone in the renovation strategy definition to promote the most efficient one. [less ▲]

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