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See detailProfiling inferior left dorsal premotor cortex: when Area 55b meets Premotor Eye-Field
Genon, Sarah ULg; Reid, Andrew; Langner, Robert et al

Poster (2017, June)

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See detailLes limites de l’administration de la PCL - R à une population de sujets schizophrènes dans le contexte médico-légal
Englebert, Jérôme ULg; Matteucci, Marie; De Page, Louis et al

Poster (2017, May 31)

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See detailBelgian speleothem records Holocene cold events?
Allan, Mohammed ULg; Deliège, Adrien ULg; Nicolay, Samuel ULg et al

Poster (2017, May 12)

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and ... [more ▼]

Speleothem is now regarded as valuable archive of climatic conditions on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments and peat cores. High spatial resolution measurements of Mg, Al, Sr, Ba were realized by using laser-ablation inductively coupled plasma mass spectrometry in the Belgian Pere Noel cave. A stalagmite from the Pere Noel (PN) cave representing 12000 years dated by U/Th method. Trace element variations in speleothem are a reflection of hydrochemical conditions. These changes were interpreted as indications of changes in climate in the Han-sur-Lesse region. The similar patterns found in δ 18O, δ 13C and chemical composition along the Pere Noel stalagmite suggests that trace elements in speleothems have the potential to provide high resolution insights into palaeoclimatic variability during the Holocene. A deeper analysis reveals several periods of significant rapid climate change during the Holocene (at 10.7-9.2 ka, 8.2-7.9 ka, 7.2-6.2 ka, 4.8-4.5 ka, and 3-2.4 ka BP), which are similar to the cold events detected from different natural paleoclimate archivers. A comparison between the geochemical analysis of Père Noël speleothem and solar activity (sunspot number) reveals a significant correlation. Spectral analysis methods reveal common solar periodicities (Gleissberg cycle, de Vries cycle, unnamed 500 year, Eddy cycles, and Hallstatt cycle). The geochemical analyses have the potential to prove that PN speleothem is sensitive to changes in solar activity on centennial and millennial timescales during the Holocene. [less ▲]

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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULg; Centonze, Prescilia ULg; Comblain, Fanny ULg et al

Poster (2017, April 27)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

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See detailTraits psychopathiques dans une population infra-clinique et traitement émotionnel
Englebert, Jérôme ULg; Bral, Laura; Dehon, Hedwige ULg et al

Poster (2017, April 19)

L’intérêt pour la psychopathie infra-clinique n’est pas neuf. Toutefois, les études sur le sujet sont encore peu nombreuses. Notre recherche a consisté à mettre à l’épreuve deux hypothèses. La première ... [more ▼]

L’intérêt pour la psychopathie infra-clinique n’est pas neuf. Toutefois, les études sur le sujet sont encore peu nombreuses. Notre recherche a consisté à mettre à l’épreuve deux hypothèses. La première, concerne la présence de « traits psychopathiques » dans la population tout-venant et la seconde tend à évaluer dans quelle mesure la présence de ces traits influence le traitement émotionnel. Pour tester ces hypothèses, nous avons créé une version « online » du SRP-III (Self Report Psychopathy). Aux soixante-quatre items initialement présents dans cette échelle nous avons ajouté dix-sept items afin d’être en mesure d’également coter la PCL-R (Psychopathy Check List- Revised). Deux groupes de chacun treize participants ont été créés sur base de leur score au SRP-III (un groupe « faibles caractéristiques psychopathique » et un groupe « fortes caractéristiques psychopathiques »). La seconde partie de l’étude consistait en une entrevue durant laquelle nous avons procédé à des mises en situation d’induction émotionnelle. Pour mesurer l’influence de cette induction, trois tâches cognitives étaient administrées aux sujets des deux groupes. La première hypothèse s’est vue confirmée à travers la récolte des données du questionnaire en ligne. Quant à la seconde hypothèse, les résultats statistiques n’indiquent aucune différence significative entre les groupes en ce qui concerne leur score aux tâches cognitives. Il est donc suggéré que la présence de traits psychopathiques n’influence pas le traitement émotionnel. Cette recherche confirme la présence de la psychopathie dans la population tout-venant et semble infirmer, parmi cette population, l’hypothèse d’un déficit du traitement émotionnel. [less ▲]

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See detailEvaluation des traits psychopathiques dans une population de sujets schizophrènes : Les limites de la PCL-R
Englebert, Jérôme ULg; Matteucci, Marie; De Page, Louis et al

Poster (2017, April 19)

Notre étude vise à déterminer si la PCL-R (Psychopathy Check List- Revised), destinée à évaluer la psychopathie et utilisée dans le contexte médico-légal, est adaptée à des sujets diagnostiqués ... [more ▼]

Notre étude vise à déterminer si la PCL-R (Psychopathy Check List- Revised), destinée à évaluer la psychopathie et utilisée dans le contexte médico-légal, est adaptée à des sujets diagnostiqués schizophrènes. Notre hypothèse principale est que plusieurs items de l’échelle peuvent être côtés avec le même score et pourtant exprimer une manière d’être et d’agir différente si le sujet est réellement psychopathe ou s’il est schizophrène. Afin d’éprouver notre hypothèse, nous avons sélectionné sept patients présentant soit une schizophrénie, soit une personnalité psychopathiques, soit considérés comme potentiels « héboïdophrènes » (schizophrénie pseudo-psychopathique) à qui nous avons administré la PCL-R. À partir d’analyses qualitatives, nous avons ensuite établi une liste d’items de la PCL-R sensibles à la psychose. Nous observons que 45% des items se révèlent positivement ou négativement influencés par la psychose au-delà de tout trait psychopathique. Sémiologiquement, c’est la présence de la dynamique paranoïde de la schizophrénie qui influence principalement les scores attribués aux items de la PCL-R. Cette recherche suggère des hypothèses concernant l’interaction psychose-psychopathie et son rapport avec des actes de violence. La conclusion de l’étude est que la PCL-R connait des limitations importantes en ce qui concerne son application à une population de sujets schizophrènes. [less ▲]

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See detailAnosognosia for behavioral disorder is related to confidence for false self-related memories in Alzheimer’s disease
Mélon, Marlène; Collette, Fabienne ULg; Salmon, Eric ULg et al

Poster (2017, March 24)

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and ... [more ▼]

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and memory cognitive systems in AD, reducing cognitive advantages of self-related memories (i.e. decreasing self reference effect, SRE) in these patients. However, how anosognosia relates to impaired metacognitive monitoring in AD, particularly for self-related memories, is still an open question. To investigate this question, an ecological memory task based on face-name associations was administrated to 20 healthy older controls (HC) and 20 mild AD patients. The influence of self-reference at encoding was assessed on subsequent name recall and recollective experience, as well as on predictive (feeling-of-knowing, FOK) and postretrieval (judgments-of-confidence, JOC) metacognitive judgments on name recognition in all participants. Furthermore relationships between metacognitive outcomes and awareness of daily cognitive and behavioral impairment was examined in AD. Altered SRE was evidenced in name recall and recollective experience in AD. Patients also showed impaired FOK and JOC, as well as lower awareness of their daily functioning impairment (anosognosia). Nevertheless, differential effect of self on metacognitive judgment in AD and HC was only observed on JOC for false memories. Importantly, anosognosia for behavioral disorders was related to post-retrieval confidence for false recognition of self-related items in AD patients. Thus, anosognosia concerning behavioral disorder and altered post-retrieval monitoring of self-related memories appear to be related in AD. We hypothesized that impaired monitoring of personal false memories may lead AD patients to rely on distorted recent reality when providing judgment about their everyday behavioral functioning. [less ▲]

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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULg; Simon, Jessica ULg; Bahri, Mohamed Ali ULg et al

Poster (2017, March 23)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULg; Blanpain, Manon ULg; Van Egroo, Maxime ULg et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

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See detailLong-range Rydberg-blockade entangling gate mediated by auxiliary atoms
Cesa, Alexandre ULg; Martin, John ULg

Poster (2017, March 09)

Arrays of qubits encoded in the ground state manifold of trapped neutral atoms appear as a promising platform for the realisation of a scalable quantum computer. Indeed, such physical qubits have a long ... [more ▼]

Arrays of qubits encoded in the ground state manifold of trapped neutral atoms appear as a promising platform for the realisation of a scalable quantum computer. Indeed, such physical qubits have a long coherence time and allow for high-fidelity single-qubit operations [1]. In such a platform, entangling two-qubit gates can be implemented by exploiting the Rydberg-blockade mechanism to produce a phase shift or a flip of the state of a target atom conditioned on the state of a control atom [2]. However, because dipole-dipole interactions fall off rapidly with the interatomic distance, such entangling gates based on Rydberg-blockade are impractical between distant qubits. In this work, we propose a protocol to implement long-range Rydberg-blockade gates (CZ or CNot) using auxillary non-coding atoms to transfer the Rydberg excitation from the control to the target qubit. The dependence of the fidelity on the number of auxillary atoms, the blockade strength and the decay rates of the Rydberg states are determined. When compared to a sequential application of nearest neighbours entangling gates, our protocol leads to a larger fidelity and a reduction of the overall gate duration (which scales linearly with the number of auxillary atoms). [1] M. Saffman, J. Phys. B: At. Mol. Opt. Phys. 49, 202001 (2016). [2] D. Jaksch, J. I. Cirac, P. Zoller, S. L. Rolston, R. Côté, and M. D. Lukin, Phys. Rev. Lett. 85, 2208 (2000). [less ▲]

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See detailAnticoherence measures for spin states
Baguette, Dorian ULg; Martin, John ULg

Poster (2017, March 09)

Among all possible spin states, spin-coherent states are the most classical because the spin expectation value in these states yields a vector of maximal norm pointing in a well defined direction. In ... [more ▼]

Among all possible spin states, spin-coherent states are the most classical because the spin expectation value in these states yields a vector of maximal norm pointing in a well defined direction. In contrast, anticoherent spin state to order t are such that <(J.n)^k> is independent of the unit vector n for k = 1, ..., t [1]. By construction, coherent and anticoherent spin states are at both ends of the spectrum of classicality. The aim of this work is to position all possible spin states on such a spectrum, that is to provide measures of anticoherence. To this aim, we introduce an axiomatic definition of anticoherence measures to any order t. In particular, we show that the total variance of a pure spin state, first introduced in [2] can be used to define a measure of anticoherence to order 1. We describe a systematic way of constructing anticoherence measures to any order that relies on the mapping between spin-j states and symmetric states of N = 2j spin-1/2. In particular, we exploit the fact that anticoherent spin states to order t have maximally mixed t-spin-1/2 reduced density matrices in the symmetric subspace [3]. [1] J. Zimba, Electron. J. Theor. Phys. 3, 143 (2006). [2] A. A. Klyachko, B. Öztop, and A. S. Shumovsky, Phys. Rev. A 75, 032315 (2007). [3] D. Baguette, T. Bastin, and J. Martin, Phys. Rev A 90, 032314 (2014). [less ▲]

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See detailCatalytic reforming of gasification tars with bi- and trimetallic catalysts optimized with organosilane precursors
Claude, Vincent ULg; Lambert, Stéphanie ULg

Poster (2017, March 07)

Biomass gasification is interesting for the production of CO + H2 from wastes and catalysts are necessary for tars degradation. Catalysts were synthesized by the sol-gel process to develop γ-Al2O3 doped ... [more ▼]

Biomass gasification is interesting for the production of CO + H2 from wastes and catalysts are necessary for tars degradation. Catalysts were synthesized by the sol-gel process to develop γ-Al2O3 doped with 10%wt of nickel and 2 wt.% of a second dopant (Co, Cu, Fe, Mn, Mo). Before their adding in AlOOH sol, metallic dopants were complexed with (OCH3)3-Si-(CH2)3-NH-(CH2)2-NH2 (EDAS) to increase their dispersion by cogelation between EDAS and AlOOH clusters. These catalysts were tested at 650°C for toluene reforming. [less ▲]

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See detailCharacterizing exoplanetary atmospheres with a mid-infrared nulling spectrograph
Defrere, Denis ULg; Léger, Alain; Absil, Olivier ULg et al

Poster (2017, March 07)

The discovery of an increasing number of terrestrial planets around nearby stars marks the dawn of a new era in the exoplanet field: the characterization and understanding of their atmospheres. To make ... [more ▼]

The discovery of an increasing number of terrestrial planets around nearby stars marks the dawn of a new era in the exoplanet field: the characterization and understanding of their atmospheres. To make significant progress, it becomes clear that a large number of exoplanetary atmospheres have to be studied at various wavelengths. This is particularly relevant for identifying possible bio-signatures. In this poster, we present a concept of a space-based mid-infrared nulling spectrograph that can characterize a large number of exoplanetary atmospheres and provide key information on their size, surface temperature, and the presence of key molecules such as CO2, H2O, CH4 and O3. The proposed mission concept would be particularly suited to characterize Proxima Cen b. [less ▲]

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See detailPhotonic photoanode for macroporous perovskite solar cells
Baron, Damien ULg; Dewalque, Jennifer ULg; Henrist, Catherine ULg et al

Poster (2017, March 01)

Organic-inorganic metal halide perovskite solar cells (PSCs) have reached power conversion efficiencies over 20%. Two archetypal PSC architectures are reported in the literature: mesoporous and planar ... [more ▼]

Organic-inorganic metal halide perovskite solar cells (PSCs) have reached power conversion efficiencies over 20%. Two archetypal PSC architectures are reported in the literature: mesoporous and planar PSCs. In the former one, a mesoporous TiO2 scaffold is incorporated into the cell. Because sizes of the mesopores are typically small compared to wavelengths of visible light, the scaffold barely scatters light. In this work, we propose to periodically structure a porous TiO2 scaffold incorporating pores with diameters comparable to wavelengths of visible light thanks to the use of colloidal crystal templating fabrication method. The resulting TiO2 scaffold filled with perovskite will constitute an opal-like photonic crystal incorporated in the solar cell, which will strongly interact with light. Through Finite Difference Time Domain (FDTD) simulations, we demonstrate that the photonic crystal induces resonances that can be exploited to modulate light harvesting in the macroporous TiO2 layer. Sunlight absorption by the PSC will be presented and discussed with dependency of pore sizes and number of opal layers. [less ▲]

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See detailINVESTIGATION DE LA QUALITE D’ANTIBIOTIQUES A BASE D'AMOXICILLINE DANS LE CADRE DE LA SURVEILLANCE DU MARCHE OFFICIEL ET PERIPHERIQUE DE QUELQUES VILLES DE LA R.D. CONGO
Kalenda Tshilombo, Nicodème ULg; Ciza Hamuli, Patient ULg; Mavungu Landu, Don Jethro ULg et al

Poster (2017, March)

Drug counterfeiting is a sad and worrisome reality, especially in developing countries where quality control is not effective and sometimes not existing at all despite political will of governments. The ... [more ▼]

Drug counterfeiting is a sad and worrisome reality, especially in developing countries where quality control is not effective and sometimes not existing at all despite political will of governments. The consequences are harmful in particular for substandard medicines that pose more threats to populations in those countries due to their direct negative impact on patients such as failure of medical treatment including development of drug resistance and even death. Socio-economic consequences and negative reputation concerning the pharmaceutical industry are also observed. Unfortunately accurate detailed data on such medicines are not easy to obtain. Most of the time available data are often estimated from case reports or studies carried out in a specific area and during a defined period.Health authorities’ in the Democratic Republic of Congo are trying to identify this scourge by set up several strategies to fight against. One of them is built on the best knowledge of drugs from several horizons through the assessment of their quality to allow appropriate measurement. In this context, we have focused our study towards amoxicillin alone and/or combined with potassium clavulanate since it is one the very used medicines in pediatric medications. The formulations are powder for suspension. Two analytical methods were developed based on the USP monography, applying isocratic liquid chromatography. Prior to their application in routine, we evaluated the suitability of these methods through validation applying the accuracy profile of total error. Since it was planned to transfer the methods to DRC, several operating factors were taken into account namely operator, day and equipment. Interesting results were obtained in terms of trueness (relative biases below than 2.3%), precision (RSD of Intermediate precision below 2.8%), accuracy (beta-expectation tolerance intervals between -6.0% and 3.8%) for the concentration levels of interest. The latter were able to allow monitoring the quality of the two active ingredients here above in the 65 samples from Congolese market. They were collected in Kinshasa, Lubumbashi, Matadi and Kolwezi at official and non-official medicines distributors, in peripheral area. The dramatic results obtained confirm that substandard and counterfeit medicines remain a crucial problem on public health in low-income countries. Appropriate measures are really needed to set up the drug quality improvement. [less ▲]

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See detailProteomic differential distribution of 53BP1 in serrated and conventional adenomas validated by histological characterisation
QUESADA-CALVO, Florence ULg; Merli, Angela-Maria ULg; MASSOT, Charlotte ULg et al

Poster (2017, February 10)

INTRODUCTION: Sessile serrated adenoma/polyp (SSA/p) is a precancerous lesion, mostly located in the right side of the colon (cecum, ascending and transverse colon). The difficulty is to visualize this ... [more ▼]

INTRODUCTION: Sessile serrated adenoma/polyp (SSA/p) is a precancerous lesion, mostly located in the right side of the colon (cecum, ascending and transverse colon). The difficulty is to visualize this lesion during colonoscopy because of its subtle appearance. MATERIAL AND METHOD: We compared proteomes of serrated polyps (SSA/p) and conventional adenomas using residual human formalin fixed paraffin embedded (FFPE) samples. FFPE-FASP method was applied on samples before label free proteomic analysis. Immunohistochemistry (IHC) characterisation of one candidate marker was performed for tissue validation on an independent set of samples including: conventional adenomas (low and high-grade dysplasia), serrated polyps (hyperplastic polyps, SSA/p and traditional serrated adenoma) and finally normal colon (taken at the margin of colorectal cancer (CRC) or of diverticular disease). RESULTS: Proteomics provided 765 proteins (out of 5992 proteins identified) significantly discriminating conventional adenomas from serrated lesions. We selected 53BP1 (Tumor suppressor p53-binding protein 1) among these for IHC validation, because of its tumor suppressor gene function and role as a mediator of DNA damage checkpoint. 53BP1 appeared significantly up-regulated in proteomes of low and high grade adenomas compared to these of normal tissue and SSA/p. 53BP1 IHC signal was located in the nucleus and the percentage of positive nucleus decreased in serrated polyps, especially in crypts and in the border epithelium, confirming part of the proteomic results. CONCLUSION: This study highlights potential marker proteins, including 53BP1 from which IHC signal was strongly decreased in some serrated polyps. The loss of 53BP1 has been associated with tumour progression and poor prognosis, while little is currently known about its involvement in precancerous CRC lesions. 53BP1 decrease of expression in the nucleus and therefore possible loss of function in some epithelial cells could reflect important changes occurring during dysplasia to neoplasia progression in serrated lesions. [less ▲]

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See detailComparison of xenogeneic graft-versus-host reactions in humanized NSG and NSG-HLA-A2/HHD mice
Ehx, Grégory ULg; SOMJA, Joan ULg; Fransolet, Gilles ULg et al

Poster (2017, February 10)

Background. Infusion of regulatory T cells (Tregs) is currently investigated in patients with graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation as well as in solid ... [more ▼]

Background. Infusion of regulatory T cells (Tregs) is currently investigated in patients with graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation as well as in solid organ transplant recipients. The in vivo efficacy of various human Treg products (naïve Tregs, memory Tregs, ex vivo activated Tregs, …) is currently assessed in NSG mice. Specifically, injection of human peripheral blood mononuclear cells (PBMC) in NSG mice induces a xenogeneic GVHD (xGVHD) syndrome that can be prevented by Treg infusion. However, this model is somewhat limited by the fact that the immunologic reaction of human PBMC is directed exclusively towards murine antigens. Aim. In this report, we compared xGVHD induced by injection of human PBMCs in NSG and in NSG mice expressing the HDD construct designed for the expression of human HLA-A0201 convalently bound to human 2 microglobuline, enabling the expression of both HLA-A2 and 2 microglobuline. Methods. NSG and NSG-HLA-A2/HHD (NSG-HLA) mice were transplanted with either HLA-A2+ or HLA-A2− human PBMCs from healthy donors. In 3 independent experiments (3 different HLA-A2+/A2− donor pairs were used, n=86), survival and xGVHD scores were monitored for the remaining days of the experiments and in a fourth experiment mice were sacrificed at day 14 to perform various analyzes on their organs. Results. NSG-HLA mice presented overall lower survival rates and higher xGVHD scores than NSG mice (median survival: 28 vs 21 days, p<0.0001). Survival difference between NSG and NSG-HLA mice was higher when they were transplanted with HLA-A2− than with HLA-A2+ donors (HLA-A2−, median survival: 35 vs 25 days, p=0.0001; HLA-A2+, median survival: 23 vs 19 days, p=0.001). Blood platelet levels, as surrogate marker of hematopoiesis activity, were reduced in NSG-HLA mice in comparison with NSG mice at day 14, suggesting higher hematopoietic hypoplasia in the NSG-HLA mice. Flow cytometry experiments showed higher human CD45+ cells engraftment in NSG-HLA mice in blood, spleen, bone marrow, lungs and liver. Further, lower CD4+/CD8+ T cells ratio were observed in these organs in NSG-HLA mice, highlighting a higher frequency of cytotoxic T cells. These differences of engraftment or ratio could not be attributed to proliferation or activation differences since no variation of either KI67 or HLA-DR were observed between the two mouse models. Supporting the promotion of cytotoxic T cells in NSG-HLA mice, lower frequency of CD45RA+ and higher frequency of TNF-α+ among CD8+ T cells were observed in these animals in comparison with NSG mice. Finally, preliminary results suggest a specific cytotoxicity toward HLA-A2+ cells in NSG-HLA mice. Conclusion. NSG-HLA-A2/HHD mice develop more severe xGVHD than NSG, characterized by a higher human cell engraftment and higher frequency of cytotoxic T cells, probably reacting specifically toward human HLA-A2 antigen. Therefore these mice may be a better model to study human acute GVHD. [less ▲]

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See detailImportance of using Geographic Information System for extensive Middle Palaeolithic open air sites in northern France. The example of Caours (Somme, France) and Beauvais (Oise, France).
Moreau, Gwénaëlle ULg; Locht, Jean-Luc; Patou-Mathis, Marylène et al

Poster (2017, February 09)

During the middle Palaeolithic, the northern France was only occupied by Neanderthals groups. However, successions of glacial and interglacial cycles explain a complex and discontinuous settlement ... [more ▼]

During the middle Palaeolithic, the northern France was only occupied by Neanderthals groups. However, successions of glacial and interglacial cycles explain a complex and discontinuous settlement, raising complication in the study of its dynamics at a regional scale. Therefore, some aspects of Neanderthals behaviour are still mischaracterize: in most cases, the function of the site and its territorial management over the northern France have to be specified. The spatial analysis of open air sites from northern France will help us to answer those questions. However, for Middle Palaeolithic sites, we can't see systematically on the field the spatial organisation directly, we sometimes need modelization. Therefore, we started to build a spatial analysis protocol adapted to this site and applied to such sites. The sites of Caours (Somme, France) and Beauvais (Oise, France) are two open air sites that are exceptionally well preserved and displaying a large amount of faunal and lithic rests. Both are perfect candidate to apply and test the new protocol. First results proved that for each site the existence of a spatial organisation as remains concentration zones. Then, we characterize this areas – number, distribution. Finally, we were able to associate them to human activity areas like hearths, butchery or knapping areas. [less ▲]

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See detailLab Pay(S)age: a Laboratory of Observation as an activator for Landscape Awareness Process
Baldin, Elisa ULg; Occhiuto, Rita ULg

Poster (2017, February 09)

The notion of Landscape Observatory (ELC 2000), in the work of LabVTP at the Faculty of Architecture in the University of Liège (Wallonia-BE), has been linked with the concept of Landscape Laboratory (R ... [more ▼]

The notion of Landscape Observatory (ELC 2000), in the work of LabVTP at the Faculty of Architecture in the University of Liège (Wallonia-BE), has been linked with the concept of Landscape Laboratory (R. Gustavsson) in order to enhance and underline perceptive, experiential and active dimensions of sites, responding to the Universities’ missions required by the ELC: education and sensitization. Lab Pay(s)age, as a new typology of landscape laboratory, has developed methodological tools for landscape research, based on a multi-scale and diachronic reading of the territory, where natural and artificial traces are the complementary elements to be reinterpreted and relaunched in new participative scenarios. The Meuse valley, reshaped by deep transformations, is the main topic for researches, concerning specific morphological, typological and social characters. All along the river, the scars of industries mark the territory as a land in search of new cycle of life1. The regeneration of abandoned industrial sites, as a practice of territorial recycle, is part of sustainability policies in urban planning, based on the enhancement of local resources. The Observatory Lab Pay(s)age, is intended as a structure for site-specific study and continuous fieldwork, concerning both the evolutionary processes of natural structures and the involution of built environment. Starting from these materials, many different regeneration methodologies and temporalities have been imagined. Following the logic promoted by the ELC, the work has started by monitoring some specific areas and by contacting different local representatives with the aim of collecting data and experiences to construct a shared knowledge of the places. Then the project has become an on-going tool including all phases in the regeneration process: observation, analysis, interpretation and re-launch of new hypothesis are fundamental elements to increase the public knowledge about the cultural factors characterizing the landscape discipline. Thus, the notion of « observatory » is a strategic device, monitoring the evolution of places in time through actions of dialogue and awareness raising, in order to get citizens re-acquire a consciousness of their territory. The collected qualitative data, describe the peculiar features of the sites, based on the local actors experience and knowledge. These elements are the basis for new scenarios, used as progressive steps leading the recovery process. For this reason, the « observatory » is also a « laboratory », as the experimental projects accompany the transformation of the places through intermediate phases. Understanding and accepting mutability as a character of landscape is a preliminary step towards a co-action, where the project accords with natural dynamics. Lab Pay(s)age, according to the ELC principles, is using the earliest local answers as re-launch factors for consecutive projects, taking into account the territorial temporalities as priority in transformation process. The presentation concerns the ongoing projects and obtained reactions, such as the earliest re-naturalization programs, some selected sites for monitoring activities and Phd researches on new regeneration methods using vegetation as an active element in reclamation of industrial sites. 1 Occhiuto, R. 2016. Healing the scars of industry in Liège, in Scape n.15, 2016 [less ▲]

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See detailComparison of two laboratory-scale ensiling methods to assess effect of reducing sugars
Herremans, Sophie ULg; Decruyenaere, Virginie; Beckers, Yves ULg et al

Poster (2017, February 07)

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See detailZinc, manganese and iron interaction within the frd3 Arabidopsis mutant
Scheepers, Maxime ULg; Spielmann, Julien ULg; Goormaghtigh, Erik et al

Poster (2017, February 01)

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See detailIdentification of proteins discriminating inflammation induced dysplasia from simple inflammation in ulcerative colitis by laser capture microdissection and label free proteomics – a pilot study
Merli, Angela-Maria ULg; QUESADA-CALVO, Florence ULg; MASSOT, Charlotte ULg et al

Poster (2017, February 01)

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when ... [more ▼]

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when tissue inflammation is present. The aim of this retrospective pilot study was to highlight proteins specifically associated with inflammation induced dysplasia in UC. We performed a pilot experiment on 15 Formalin-Fixed, Paraffin-Embedded (FFPE) samples isolated from 5 cases of UC patients with a Polypoïd Pedunculated dysplasia (UC-PP). We compared the proteomes of the UC-PP, the inflammatory (UC-I) and the normal (UC-NL) tissues of each patient. We performed Laser Capture Microdissection (LCM) in order to collect only epithelial cells, avoiding inflammatory infiltrating ones. Label free proteomic analysis using a 2D-nanoUPLC coupled with a hybrid Quadrupole-Orbitrap was applied, as well as differential analysis on the paired samples. Immunohistochemistry (IHC) characterisation of one of the selected proteins of interest was used for validation. Out of 985 quantified proteins, 7 were found significantly more abundant in UC-PP compared to UC-I tissues, with 6 being only detected in UC-PP using proteomics. One of these is Solute Carrier Family 12 member 2 (SLC12A2), also known as Na-K-2Cl co-transporter 1 (NKCC1), a protein involved in ionic balance, in T-cell migration promotion and in some features involved in cancer development like proliferation, migration or invasion. IHC results obtained were in correlation with proteomic results and showed that SLC12A2 was more abundant in UC-PP tissue than in UC-I and UC-NL tissues, with a signal clearly delimiting the dysplastic region from the surrounding inflammatory tissue. This pilot experiment shows a different proteomic profile in inflammation-associated dysplasia and simple inflammation. This should be replicated using other types of dysplasia in IBD. SLC12A2 could be a potential biomarker of inflammation-associated dysplasia. [less ▲]

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See detailA multiscale model of the human cardiovascular system can account for the Frank-Starling effect on vascular filling therapy
Kosta, Sarah ULg; Pironet, Antoine; Negroni, Jorge et al

Poster (2017, February 01)

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See detailImproved Blood Glucose Forecasting Models using Changes in Insulin Sensitivity in Intensive Care Patients
Uyttendaele, Vincent ULg; Dickson, Jennifer; Shaw, Geoff et al

Poster (2017, February 01)

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy ... [more ▼]

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy has shown improved outcomes, but have been proven difficult to repeat or achieve safely. STAR (Stochastic TARgeted) is a model-based glycaemic control protocol using a stochastic model to forecast distributions of likely future changes in insulin sensitivity (SI) based on its current value. This can be used to determine likely future blood glucose (BG) levels for a given intervention, enabling the most optimal dose selection that best overlaps a clinically defined BG target band. This study presents a novel 3D model capable to predict likely future distribution of SI using both current SI and its prior variability (%ΔSI). Methods: Metabolic data from 3 clinical ICU cohorts totalling 819 episodes and 68629 hours of treatment under STAR and SPRINT protocols are used in this study. Data triplets (%ΔSIn, SIn, SIn+1) are created and binned together in a range of %ΔSI = [-100%, 200%] and SIn = [1.0e-7, 2.1e-3] in bin sizes of %ΔSI = 10% and SIn = 0.5e-4. The 5th, 50th, and 95th percentile of SIn+1 are determined for each bin where data density is high enough (>100 triplets) and compared to the previous stochastic model. The predictive power of the two models are compared by computing median [IQR] per-patient percentage prediction of SI within the 5th-95th and 25th-75th percentile ranges of model predictions. Results: Results show the previous model is over-conservative for ~77% of the data, mainly where %ΔSI is within an absolute 25% change. The percentage change in the 90% CI width in this region is reduced by ~25-40%. Conversely, non-conservative regions are also identified, with 90% CI width increased up to ~80%. Predictive power is similar for both model (60.3% [47.8%, 71.5%] vs. 51.2 [42.9%, 59.2%] within 25th-75th and 93.6% [85.7%, 97.3%] vs. 90.7% [84.4%, 94.6%] within 5th-95th range). Conclusions: The new 3D model achieved similar predictive power as the previous model by reducing the 5th-95th percentile prediction range for 77% of the data, predominantly where SI is stable. If the conservatism of the previous model reduces risk of hypoglycaemia, it also inhibits the controller’s ability to reduce BG to the normal range by safely using more aggressive dosing. The 3D new model thus better characterises patient-specific response to insulin, and allows more optimal dosing, increasing performance and safety. [less ▲]

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See detailNew data on the Mesozoic radiation of chelonioids
Scavezzoni, Isaure ULg; Fischer, Valentin ULg

Poster (2017, February)

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See detailMegaloolithid dinosaur eggs: scrambled parataxonomy and nesting strategies
Jentgen, Benjamin ULg; Stein, Koen; Fischer, Valentin ULg

Poster (2017, February)

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See detailThe Bright and Dark Sides of elliptical galaxies
Biernaux, Judith ULg

Poster (2017, January 29)

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See detailChildren’s engagement in physical education could be improved by stories and imagination.
De Sousa Morgado, Liliane ULg; Jidovtseff, Boris ULg

Poster (2017, January 27)

Introduction: The development of fundamental motor skills is essential during childhood and should be a learning outcome in the physical education (PE). With the children between 3 to 6 years old it could ... [more ▼]

Introduction: The development of fundamental motor skills is essential during childhood and should be a learning outcome in the physical education (PE). With the children between 3 to 6 years old it could be sometime difficult to get their attention and motivation during PE lessons. Teachers have to use a very adapted pedagogical approach in order to get all children’s engagement. Experience: The CEReKi is a research center of the University of Liège (Belgium) that has developed adapted activities where preschools children are playing and at the same time developing perceptuals and fundamental motor skills. From our field experience one of the more efficient ways to get children attention and participation is to introduce the activities with stories and imagination. Teachers from CEReKi are using fantasy in order to invite children into a funny world where everything could become possible like the "the never-never land of Peter Pan". The way of telling the story as well as the used characters (like the wolf) must be adapted to the age of the children. Critical analysis: From our experience, using stories and imagination is effective in increasing children‘s engagement during PE as it makes activities more fun and more enjoyable. Even if we don’t have any measurement on its effect, we are convinced that such approach improve children’s motor learning. However using stories and imagination with the children is neither a natural nor an easy thing for inexperienced teachers. The use of fantasy with the children should be introduces in the vocational training. Conclusions: With more than twenty years of experience, we believe that stories and imagination are powerful factors that makes physical activities funny and enjoyable for the children. Such strategy may positively enchase young people’s attitudes towards physical education and ultimately, physical activity participation. [less ▲]

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See detailElaboration of a water familiarization testing battery adapted for young children
Vandermeulen, Mary ULg; Schiettecatte, Delphine; Delvaux, Anne ULg et al

Poster (2017, January 27)

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See detailUse of complementary biophysical approaches to study the interactions of fatty acid hydroperoxides with biomimetic plant plasma membranes
Deboever, Estelle ULg; Nasir, Mehmet Nail ULg; Deleu, Magali ULg et al

Poster (2017, January 20)

In the actual context, biopesticides have emerged as a main alternative to conventional agriculture1. Hence, elicitors are metabolites naturally produced by microorganisms, pathogenic or not, and plants ... [more ▼]

In the actual context, biopesticides have emerged as a main alternative to conventional agriculture1. Hence, elicitors are metabolites naturally produced by microorganisms, pathogenic or not, and plants which are able to induce the natural resistance of plants. Also, they have proved to be excellent candidates for biological control. In this context, the lipoxygenase pathway leads to the formation of fatty acid degradation products, called oxylipins, which appear to be crucial agents in plant defence mechanisms2,3. Moreover, with their broad spectrum of action and their possible inducibility, oxylipins appear to be promising candidates for their use as elicitors4. This work focuses on two hydroperoxy-derived oxylipins, the 13(S)-hydroperoxy-octadecadienoic acid (13-HPOD) and the 13(S)-hydroperoxy-octadecatrienoic acid (13-HPOT). The study of the interaction of such compounds with representative plant plasma membrane lipids is essential to understand plant resistance mechanisms. Several in silico and experimental techniques of biophysics showed that acyl-hydroperoxides have significant adsorption capacity and a strong affinity for model membranes. They may also penetrate biological membrane but no permeabilisation effect was observed in this work. Slight conformational differences seem to have a significant impact on their ability to interact with plant plasma membranes. Based on these results, further investigation of the interactions of fatty acids hydroperoxides, even more on the 9-forms, with plant plasma membranes and eventually in the presence of phytopathogenic species, would allow a better understanding of the innate immunity and, on the longer term, could lead to the development of new elicitors with biological mechanisms potentially independent of membrane protein receptors. [less ▲]

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See detailGlobal Simulation of UV atmospheric Emissions
Gonzalez-Galindo; Lopez-Valverde; Forget et al

Poster (2017, January 19)

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See detailA persistent meteoric layer in Mars' atmosphere
Crismani; Schneider; Plane et al

Poster (2017, January 18)

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See detailThree Types of Aurora observed by MAVEN/IUVS: Implications for Mars’ upper Atmosphere Energy Budget
Connour; Schneider; Jain et al

Poster (2017, January 17)

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See detailThe added value of plasma or urinary NGAL concentrations in clinical practice
Gregoire, Emilien ULg; Claisse, Guillaume; GUIOT, Julien ULg et al

Poster (2017, January 13)

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See detailTracking the Subtle Mutations Thriving Host Sensing by the Plant Pathogen Streptomyces scabies
Deflandre, Benoit ULg; Jourdan, Samuel ULg; Francis, Isolde Maria et al

Poster (2017, January 12)

Le modèle de la pathogénicité végétale chez les Streptomyces, S. scabies est responsable de la maladie de la galle commune. La thaxtomine est la phytotoxine qui cause cette maladie. Il y a peu, la voie de ... [more ▼]

Le modèle de la pathogénicité végétale chez les Streptomyces, S. scabies est responsable de la maladie de la galle commune. La thaxtomine est la phytotoxine qui cause cette maladie. Il y a peu, la voie de production de la toxine a été découverte : celle-ci met en oeuvre un double mécanisme de régulation génétique. Cependant, certains aspects de la perception de son hôte par le pathogène sont toujours inconnus. Dans ce poster, nous proposons plusieurs hypothèses pour expliquer comment quelques éléments subtiles peuvent être à l'origine de ce mécanisme de pathogénicité. [less ▲]

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See detailIron, zinc and manganese interaction within the frd3 Arabidopsis mutant
Scheepers, Maxime ULg; Spielmann, Julien ULg; Goormaghtigh, Erik et al

Poster (2017, January 12)

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See detailMacroevolutionary patterns in sea breams, emperors and allies (Sparoidea, Acanthomorpha)
Santini, Francesco; Olivier, Damien ULg; Frederich, Bruno ULg

Poster (2017, January 07)

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See detailRaman imaging for diagnostic application
Malherbe, Cédric ULg; Gilbert, Bernard ULg; Eppe, Gauthier ULg

Poster (2016, December 19)

Specific dynamic biochemical compositions and molecular structures characterise healthy cells and tissues. This also stands for pathologies or cellular abnormalities which are accompanied by biochemical ... [more ▼]

Specific dynamic biochemical compositions and molecular structures characterise healthy cells and tissues. This also stands for pathologies or cellular abnormalities which are accompanied by biochemical and molecular changes. Raman spectroscopy can provide unique inputs to correlate the molecular composition and its variations with the diagnosis. In addition, the presence of metal nanoparticles in the molecule vicinity induces a remarkable enhancement (up to 1000000 times) of the Raman signal of small molecules (known as SERS effect). It opens towards applications in the field of trace analysis. In preparation for clinical applications, we evaluate, by Raman mapping, the signal detected from a SERS target deposited on solid state support. [less ▲]

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See detailIntegrated microfluidic device for the synthesis of SERS substrates
Emonds-Alt, Gauthier ULg; Malherbe, Cédric ULg; Monbaliu, Jean-Christophe ULg et al

Poster (2016, December 19)

The goal of this work is to develop a quantitative analytical method for the glyphosate and its major metabolite the aminomethylphosphonic acid (AMPA) by coupling microfluidics with surface enhanced Raman ... [more ▼]

The goal of this work is to develop a quantitative analytical method for the glyphosate and its major metabolite the aminomethylphosphonic acid (AMPA) by coupling microfluidics with surface enhanced Raman spectroscopy (SERS). This work is divided into 4 axes : (a) bimetallic nanoparticles synthesis in a microreactor, (b) nanoparticles functionnalisation, (c) SERS quantification of glyphosate/AMPA and (d) miniature prototype development composed of axes a to c. The first section aims at the synthesis of bimetallic nanoparticles (Au-Ag, Au-Cu and Ag-Cu) in a microfluidic device. This microfluidic device integrates a first section for the synthesis of monometallic nanoparticles (core) and a second section for the reductive deposition of a second metal (shell). The second axe of this work deals with the functionnalisation of nanoparticles to improve the selectivity of this method for the selected analytes. Two types of functionnalisation are studied : PEGylation (a) with multi-arm PEG ending with -SH and/or (b) with linear heterobifunctionnal PEG. The third axe consists in measuring quantitatively glyphosate and AMPA in different matrices, such as water, urine and fruit juice. Finally, the forth axe deals with the development of a portable detection system to perform on-site analysis. This prototype integrates the microfluidic device for nanoparticles synthesis, their functionnalisation, an injection port followed by a mixing section for the sample and an integrated Raman spectrometer for in-line analysis. [less ▲]

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See detailPrésentation du projet Economie et pratiques des sociétés gravettiennes dans le Nord-Ouest de l’Europe (ECOPRAT)
Touzé, Olivier ULg; Salomon, Hélène ULg; Goutas, Nejma et al

Poster (2016, December 17)

Nous présentons dans cette contribution un projet collectif porté par le Service de Préhistoire de l’Université de Liège et l’équipe Ethnologie préhistorique de l'unité mixte de recherche du CNRS ... [more ▼]

Nous présentons dans cette contribution un projet collectif porté par le Service de Préhistoire de l’Université de Liège et l’équipe Ethnologie préhistorique de l'unité mixte de recherche du CNRS Archéologie et Sciences de l'Antiquité. Le projet « ECOPRAT » entend contribuer au renouvellement des connaissances relatives aux sociétés gravettiennes du Nord-Ouest européen, et prolonger ainsi la dynamique de recherche actuelle touchant ces sociétés (Bodu et al., 2013). Il s’inscrit dans une perspective pluridisciplinaire envisagée grâce à l’association d’études technologiques, tracéologiques et archéozoologiques. Quatre sites majeurs du Nord-Ouest européen ont été retenus : les gisements de plein air de Maisières-Canal (Prov. Hainaut, Belgique) et d’Ormesson – Les Bossats (Seine-et-Marne, France), et les grottes de Goyet (Prov. Namur, Belgique) et du massif d’Arcy-sur-Cure (Yonne, France). Les sites sélectionnés possédant des historiques de recherche spécifiques, la stratégie d’analyse adoptée pour chacun d’eux est développée en adéquation avec l’état des connaissances actuelles. Les recherches sont ainsi guidées par l’obtention de données inédites qui doivent permettre, à terme : 1) une lecture renouvelée et croisée des industries lithiques et osseuses, ainsi que des ensembles fauniques et des matières colorantes découverts dans ces gisements, 2) un rééquilibrage quantitatif et qualitatif de l’intégration des différentes sources documentaires disponibles, la recherche s’étant davantage concentrée depuis plus d’un siècle sur les données de l’industrie lithique. Les deux gisements de plein air réunissent les conditions indispensables au développement d’une approche interdisciplinaire permettant de croiser objets et méthodes d’étude, afin de proposer une lecture fine des comportements techniques et économiques des sociétés gravettiennes. A cet égard, cette contribution est l’occasion de présenter les premiers résultats obtenus sur le site de Maisières-Canal. Les recherches réalisées jusqu’à présent permettent de réévaluer l’importance de l’industrie sur matières dures d’origine animale, au sein de laquelle le travail de l’ivoire de mammouth se révèle particulièrement significatif. En outre, le corpus faunique traduit une exploitation récurrente du lièvre, ce type de comportement s’avérant singulier au regard de ce qui est habituellement documenté chez les sociétés du Gravettien. Parmi les différentes activités susceptibles de laisser une trace archéologique, l’usage de matières colorantes apparaît particulièrement discret dans le cadre spatio-temporel considéré. Cet usage est cependant avéré dans les grottes d’Arcy-sur-Cure (grottes du Renne et du Trilobite), lesquelles permettront ainsi d’entreprendre une étude ciblée de ce phénomène. Enfin, les grottes de Goyet offrent la possibilité de contribuer à la connaissance de la séquence gravettienne du Nord-Ouest européen. Si le long historique des fouilles menées dans ces grottes, ainsi que les mélanges manifestes affectant les collections, ne permettent pas d’envisager une étude approfondie des comportements gravettiens, des observations préliminaires permettent en revanche de s’interroger sur le potentiel de ces sites pour la reconstitution de cette séquence. A l’instar de ce qu’ont montré les travaux récemment conduits sur le Gravettien de Spy (Pesesse & Flas, 2013), il est en effet vraisemblable que les grottes de Goyet aient été occupées à plusieurs moments de la période gravettienne. BODU P., CHEHMANA L., KLARIC L., MEVEL L., SORIANO S., TEYSSANDIER N. (dir.), 2013. Le Paléolithique supérieur ancien de l’Europe du Nord-Ouest : réflexions et synthèses à partir d’un projet collectif de recherche sur le centre et le sud du Bassin parisien, Actes du colloque de Sens, 15-18 avril 2009. Paris : Société préhistorique française (Mémoires de la Société préhistorique française, 56), 516 p. PESESSE D., FLAS D., 2013. Which Gravettians at Spy? In : ROUGIER H., SEMAL P. (eds), Spy Cave. 125 years of multidisciplinary research at the Betche-aux-Roches (Jemeppe-sur-Sambre, Province of Namur, Belgium). Volume I. Bruxelles : Institut royal des Sciences naturelles de Belgique, Société royale belge d'Anthropologie et de Préhistoire, NESPOS Society (Anthropologica et Praehistorica, 123), pp. 257-268. [less ▲]

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See detailBioaccumulation of trace metals in Mytilus galloprovincialis from the Algerian west coast
Rouabhi, Leila; Rouanne, Hassen Omar; Benkrama, Hadjer et al

Poster (2016, December 16)

Algeria has a 1622 km long coastal strip where a large proportion of the population and the main economic and industrial activities of the country are concentrated. Its coastal fringe therefore suffers ... [more ▼]

Algeria has a 1622 km long coastal strip where a large proportion of the population and the main economic and industrial activities of the country are concentrated. Its coastal fringe therefore suffers from various degradations. In particular, the Bay of Oran is housing industrial, commercial, fishing and recreational activities, where 80 % of domestic and industrial wastewaters are not purified before being discharged into the sea. Thus, the aim of the present work was to evaluate the degree of metallic contamination of coastal waters of western Algeria. Trace metals (Zn, Cu, Ni, Fe and Pb) were measured by atomic absorption spectroscopy in the dry soft tissues (gills and gonads) of the mussel Mytilus galloprovincialis Lamarck, 1819 collected during the four seasons of year 2010 in 2 sites: the highly polluted Oran harbor (S1) and Ain Defla (S2), a site distant enough from Oran and presumed little contaminated. Oran harbor was globally more contaminated than Ain Defla, especially for Fe, Zn and Ni. However, Pb levels were higher at Ain Defla with concentrations up to 3.35 ± 0.25 ppm in the gills. Metal concentrations differed between organs. Fe, Zn and Cu were more accumulated in gills (46.91 ± 1.60 ppm, 25.6 ± 1.07 ppm, 2.68 ± 0.50 ppm, respectively) compared to gonads (29.06 ± 1.07 ppm, 21.76 ± 1.46 ppm ppm, 1.44 ± 0.20 ppm, respectively). Each metal followed a seasonal trend, showing concentration peaks during winter and spring for gills and autumn for gonads. This study demonstrated the need to biomonitor the metallic contamination of Algerian coasts. But such monitoring surveys, relying on organisms, will require consensual sampling and analytical protocols to avoid hazardous conclusions due to tissue speciation and accumulation seasonality. [less ▲]

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See detailDetermining the Substorm Onset Instability Using Ground and Space-Based Measurements
Rae, Jonathan; Watt, Clare; Murphy, Kyle et al

Poster (2016, December 16)

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See detailCopper toxicity on coral holobiont photosynthetic processes
Georges, Nadège; Richir, Jonathan ULg; Batigny, Antoine et al

Poster (2016, December 16)

Copper (Cu), an essential micronutrient to organisms, may become toxic when present at too high environmental concentrations. This metal remains an aquatic contaminant of concern, notably because of its ... [more ▼]

Copper (Cu), an essential micronutrient to organisms, may become toxic when present at too high environmental concentrations. This metal remains an aquatic contaminant of concern, notably because of its recent re-use as biocide in metal-based antifouling paints. The aim of this study was to monitor the physiological alterations in a zooxanthellate coral species and its endosymbionts (i.e. the coral holobiont) exposed to increasing Cu concentrations. Nubbins of Seriatopora hystrix were exposed for 8 days in 1 L intermittent respirometers to 5 nominal Cu concentrations: 0-2-5-15-50 ppb. Respirometers were maintained at 25.0±0.2°C with successive open/close cycles of 30 min. A 12/12 hours day-night light regime was applied with constant daylight intensity of 200 μmol photons m-2 s-1. Water renewal rate during the 30 min open cycles was 15 mL.min-1. The photosynthetic performances of coral endosymbionts were assessed daily with a fluorescence imaging system (imaging-PAM). At the end of the 8-days experiment, the maximal photochemical quantum yield (FV/FM) of coral nubbins had decreased by 12% and 38%, respectively, in the 15 ppb and 50 ppb treatments. This decrease was even greater for the effective photochemical quantum yield (ɸPSII) with values dropping by 41% and 54%, respectively. Cu exposure also affected the symbiosis between the coral host and its endosymbionts. Nubbins of the 15 ppb treatment slightly lightened from day 6, whilst nubbins exposed to the 50 ppb treatment lightened from day 3, and started to bleach from day 6. The analysis of nubbins’ primary productivity did not coincide with the above observations, the oxygen production within each respirometer remaining relatively constant during the overall experiment for all treatments. This unexpected observation may be the sign of a compensation mechanism. In conclusion, Cu affected the photosynthetic processes of S. histrix within 8 days from relevant environmental concentrations of 15 ppb. The exposure of corals to toxic chemicals thus has to be considered as an additional stressor to, e.g., ocean acidification or elevated temperature, which may disturb their ecophysiology and lead to bleaching. [less ▲]

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See detailHead shape disparity of the cod icefishes Trematominae (Notothenioidei, Teleostei)
Frederich, Bruno ULg; Heindler, Franz M.; Dettai, Agnès et al

Poster (2016, December 16)

The suborder Notothenioidei (Teleostei) has undergone a remarkable adaptive radiation in the Southern Ocean. Within this suborder, the subfamily Trematominae is endemic to Antarctic waters and represents ... [more ▼]

The suborder Notothenioidei (Teleostei) has undergone a remarkable adaptive radiation in the Southern Ocean. Within this suborder, the subfamily Trematominae is endemic to Antarctic waters and represents a dominant component of the shelf fish fauna. After recent advances in molecular phylogenetics, 14 species of Trematomus are currently recognized (including Pagothenia and Cryothenia spp.) comprising both considerable morphological and ecological diversity. Here, we aim to illustrate the main axes of shape variation in Trematomus and explore the evolution of their morphology. A dataset of 96 specimens representing 10 species of Trematomus from the collection of the Natural History Museum of Paris was assembled, and landmark-based geometric morphometrics was applied to quantify head shape disparity. Regular regression analysis revealed significant interspecific allometry while a low percentage of shape variation was explained by size (R2 = 0.11; P < 0.001). Main shape variation across species was explored using a principal component (PC) analysis on shape variables. Two groups diverged along PC1: (1) T. bernacchii, T. hansoni, T. pennellii and T. tokarevi have short cephalic profiles with larger cheeks (lowest values along PC1); and (2) T. lepidorhinus, T. eulepidotus and T. newnesi show lengthened cephalic profiles with larger eyes (highest values along PC1). Trematomus scotti differed from all other species mainly along PC3 indicating more elongated cheeks. Phenogram based on Procrustes shape distances will be compared to molecular phylogenetic trees and morphometric data will be mapped onto phylogenetic trees in order to illustrate the mode of phenotypic diversification of Trematomus during evolution. [less ▲]

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See detailTuta absoluta (Lepidoptera: Gelechiidae) ability to develop on potato tubers
Bawin, Thomas ULg; De Backer, Lara ULg; Yarou, Boni Barthélémy ULg et al

Poster (2016, December 16)

Tuta absoluta (Lepidoptera: Gelechiidae) is a widespread pest that threatens commercial production of solanaceous crops. Larvae feed on the mesophyll of all aerial parts of the plants resulting in ... [more ▼]

Tuta absoluta (Lepidoptera: Gelechiidae) is a widespread pest that threatens commercial production of solanaceous crops. Larvae feed on the mesophyll of all aerial parts of the plants resulting in significant yield losses and cosmetic damages.It is classically assumed that underground plant parts are not affected but larval development on potato tubers has recently been suspected. However, this assumption is poorly supported in the literature. Potato tubers might represent an unsuspected mean of persistence and dispersal in agricultural environments.Oviposition tests were here conducted using dormant and active (sprouts less than 5 cm) potato tubers in net cages. Oviposition only occurred on the sprouts of active tubers, supporting larval growth until adult emergency. Tuber dissection revealed burrows starting from sprouts inside the flesh. Additional fitness assays were conducted on non-sprouted tubers and revealed that first instar larvae were able to enter the skin and create burrows, living inside and feeding on potato flesh, although none of them survived. [less ▲]

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See detailExploring a Mediterranean mesozooplankton 13 year time-series.
Fullgrabe, Lovina; Richir, Jonathan ULg; Batigny, Antoine et al

Poster (2016, December 16)

Zooplankton plays diverse crucial roles within the marine ecosystem and can also be used as bio- indicator of climate changes since it is very sensitive to environmental changes. Therefore it is essential ... [more ▼]

Zooplankton plays diverse crucial roles within the marine ecosystem and can also be used as bio- indicator of climate changes since it is very sensitive to environmental changes. Therefore it is essential to consider long-term plankton series. Given the analysis of plankton samples is time- consuming, it requires an effective and rapid analytical method. We have used in this work a supervised learning approach adapted for the semi-automatic classification of digital images of the mesozooplankton of the Bay of Calvi (Corsica, France) by using the Zoo/PhytoImage software. Together with a 11-years long zooplankton time-series, a set of nine environmental variables were monitored in order to identify controlling factors and determine whether the communities were sensitive to global environmental changes. The main components of the mesozooplankton community were characterized by both seasonal and inter-annual variability. Additionally, variation of holoplankton and meroplankton differentiated one from each other. The holoplanktonic community could be split into two subgroups according to its variation in function of the environment: cladocerans and appendicularians, and to a lesser extent, copepods on one hand, and cnidarians, chaetognathes and thaliaceans, on the other hand. Regarding inter-annual variation, one year (2007) showed particularly low production of total zooplankton which was also the case for all the different holoplanktonic taxa. Accounting for that phenomenon were identified some potentially underlying environmental factors. Finally, although water temperature increased significantly over the last years along with the frequency of marine heat wave events, no evident change in the global zooplankton composition was observed yet. [less ▲]

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See detailInsects complex associated with the tropical basil, Ocimum gratissimum L. (Lamiaceae) in southern Benin.
Yarou, Boni Barthélémy ULg; Bokonon-Ganta, H. Aimé; Assogba Komlan, Françoise et al

Poster (2016, December 16)

Tropical basil is an aromatic leafy vegetable used for its medicinal and therapeutic properties in numerous countries in West Africa (Benin, Nigeria, Togo, etc.). In Benin, it is produced on almost all ... [more ▼]

Tropical basil is an aromatic leafy vegetable used for its medicinal and therapeutic properties in numerous countries in West Africa (Benin, Nigeria, Togo, etc.). In Benin, it is produced on almost all urban and periurban garden throughout the year for fresh market. Until now there are few or nearly no publications about the arthropod community of this specie, even less in the context of Benin. Thus, to assess this community, basil plots were mowed using a sweep net in three localities (Ouidah, Togba and Sèmè) of southern Benin. Preliminary results focus on the different insect families that colonized tropical basil in southern Benin environmental conditions. These include: Aphididae (Homoptera), Cercopidae (Homoptera), Chrysomelidae (Coleoptera), Coccinelledidea (Coleoptera), Meloidae (Coleoptera), Braconidae (Hymenoptera), Ichneumonidae (Hymenoptera), Formicidae (Hymenoptera), Vespidae (Hymenoptera), Apoidae (Hymenoptera), Reduviidae (Heteroptera), Pentatomidae (Heteroptera), Pyrgomorphidae (Orthoptera), Acrididae (Orthoptera), Syrphidae (Diptera), Diopsidae (Diptera). Among these families, there are pests: Aphis gossypii G. (Homoptera: Aphididae), Zonocerus variegatus L. (Orthoptera: Pyrgomorphidae), etc.; predators: Ischiodon aegyptius W. (Diptera: Syrphidae), Cheilomenes spp. (Coleoptera: Coccinelledidea), Rhynocoris spp. (Heteroptera: Reduviidae), etc.; parasitoids and pollinators. From this study, it appeared that there is a large diversity of families and functional groups (pests, predators, parasitoids and pollinators) associated with tropical basil . Moreover, the presence of natural enemies could be an advantage for farmers in intercropping systems. This would help reduce the use of synthetic insecticides. This result, which is a first knowledge of the insect fauna associated with tropical basil under the environmental conditions of Southern Benin, will be supplemented by a spatio temporal study to assess the variability and the dynamics of this insect fauna. [less ▲]

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See detailEnergy Dissipation in Saturn’s Magnetotail: A Comparative Magnetotail Approach
Yao, Zhonghua ULg; Coates, Andrew; Ray, Licia et al

Poster (2016, December 16)

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Peer Reviewed
See detailFeeding ecology of metamorphic and paedomorphic palmate newts (Lissotriton helveticus) in Larzac
Didaskalou, Emilie; Lejeune, Benjamin ULg; Lepoint, Gilles ULg et al

Poster (2016, December 16)

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See detailIntegrating Non-Collocated Well and Geophysical Data to Capture Lithological Heterogeneity at a Managed Aquifer Recharge and Recovery Site
Gottschalk, Ian; Hermans, Thomas ULg; Caers, Jef et al

Poster (2016, December 15)

Aquifer recharge and recovery (ARR) is the process of enhancing natural groundwater resources and recovering water for later use by constructing engineered conveyances. Insufficient understanding of ... [more ▼]

Aquifer recharge and recovery (ARR) is the process of enhancing natural groundwater resources and recovering water for later use by constructing engineered conveyances. Insufficient understanding of lithological heterogeneity at ARR sites often hinders attempts to predict where and how quickly infiltrating water will flow in the subsurface, which can adversely affect the quality and quantity of available water in the ARR site. In this study, we explored the use of electrical resistivity tomography (ERT) to assist in characterizing lithological heterogeneity at an ARR site, so as to incorporate it into a flow and contaminant transport model. In this case, we had non-collocated well core log data and ERT data from a full-scale ARR basin. We compared three independent methods for producing conditional lithology-resistivity probability distributions: 1) a search template to relate the nearest logged well lithologies with ERT resistivity panels, given search criteria; 2) a maximum likelihood estimation (MLE) to match bimodal normal distributions to the histogram of each ERT line; and 3) variogram-based lithology indicator simulations constrained to well data. Each approach leverages Bayes’ Rule to estimate lithology probability given electrical resistivity. The simplest approach (method 1) yields an erroneous conditional probability function where sand dominates the conditional probability at nearly all resistivities, due in part to the strong presence of sand in the wells nearest the ERT lines. The approaches using MLE and lithology simulations (methods 2 and 3) produce similar, more realistic lithofacies probability functions. The range of resistivities where clay and sand overlap differs between methods 2 and 3: ranging between 100 and 200 ohm-m for method 2, and between 30 and 50 ohm-m for the method 3. These differences affect the posterior lithology distributions in multiple point geostatistical (MPS) simulations, and in turn, predictions of flow from models which integrate these results. To test the models, we can compare measured breakthrough times of recharged water at the site to groundwater flow simulation results using the lithofacies models created by each method. The methods described here can inform the integration of non-collocated geophysical data into a variety of applications. [less ▲]

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See detailA step-by-step recipe of band-spli3ng technique for isola8on of ionospheric signal in L-band InSAR data
Furuya, Masato; Suzuki, Takato; De Rauw, Dominique ULg

Poster (2016, December 15)

Ionospheric signals are widely regarded as nuisance in low- frequency InSAR data, and thus a variety of correction techniques have been proposed. Although band-splitng of range spectrum has been shown to ... [more ▼]

Ionospheric signals are widely regarded as nuisance in low- frequency InSAR data, and thus a variety of correction techniques have been proposed. Although band-splitng of range spectrum has been shown to be effectve (Brcic et al., 2010; Rosen et al., 2010; Gomba et al., 2015), the band- spliting technique seems to have not been widely used. Whereas this would be partly because the impacts of ionosphere on InSAR data are not necessarily serious, we consider that this could be also because the details of the technique have not been reproducibly shown. Here we show our step-by-step recipe of the band-spliting technique, and demonstrate two case studies that reveal the effectiveness of the technique. [less ▲]

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See detailElectrical Resistivity Monitoring of Heat Tracer to Characterize Lab-Scale Hydraulic Conductivity Distributions
Adetokunbo, Peter; Hermans, Thomas ULg; Oware, Erasmus

Poster (2016, December 14)

Knowledge of the spatial variations of hydraulic conductivity (K) is crucial to almost every hydrogeological investigation. The representative scale of K estimates from traditional slug and pumping tests ... [more ▼]

Knowledge of the spatial variations of hydraulic conductivity (K) is crucial to almost every hydrogeological investigation. The representative scale of K estimates from traditional slug and pumping tests are, however, inadequate to accurately predict hydrogeological processes. There is increasing interest in the application of electrical resistivity tomography (ERT) to quantify spatially continuous K variations. ERT estimation of high-resolution K distributions, however, requires continuous injection of saline tracer (ST) into an aquifer over an extended period, which is feasible but impractical. Here, we present electrical resistivity thermography (ERTh) to evaluate the potential application of time-lapse ER monitoring of heat tracer (HT) to characterize high-resolution K architectures. Unlike ST, long term HT experiments are comparatively easier to manage and repeatable with minimal environmental impact. We estimate K variations via petrophysical coupling of flow and heat transport with joint time-lapse ER and discrete multi-level temperature breakthrough curves. We illustrate the strategy with a 2-D lab-scale sandbox experiment. To construct the heterogeneous field, three lenses with high-K properties with each consisting of gravel, coarse sand, and a mixture of coarse and fine sand, were created within a background of comparatively low-K fine sand. The experiment involved continuous injection and extraction of heat, respectively, at the left and right boundaries of the lab-scale aquifer. We simultaneously performed time lapse ER monitoring of the heat transport and temperature measurements at four discrete multi-levels near the heat extraction well. Results of the coupled inversions demonstrate that ER monitoring of heat tracer provides a unique opportunity to characterize high-resolution spatially continuous K variations, which seems more practical for field applications in contrast to that of the traditional ST. [less ▲]

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See detailThe complex behavior of the satellite footprints at Jupiter: the result of universal processes?
Bonfond, Bertrand ULg; Grodent, Denis ULg; Badman, Sarah V. et al

Poster (2016, December 14)

At Jupiter, some auroral emissions are directly related to the electromagnetic interaction between the moons Io, Europa and Ganymede on one hand and the rapidly rotating magnetospheric plasma on the other ... [more ▼]

At Jupiter, some auroral emissions are directly related to the electromagnetic interaction between the moons Io, Europa and Ganymede on one hand and the rapidly rotating magnetospheric plasma on the other hand. Out of the three, the Io footprint is the brightest and the most studied. Present in each hemisphere, it is made of at least three different spots and an extended trailing tail. The variability of the brightness of the spots as well as their relative location has been tentatively explained with a combination of Alfvén waves’ partial reflections on density gradients and bi-directional electron acceleration at high latitude. Should this scenario be correct, then the other footprints should also show the same behavior. Here we show that all footprints are, at least occasionally, made of several spots and they all display a tail. We also show that these spots share many characteristics with those of the Io footprint (i.e. some significant variability on timescales of 2-3 minutes). Additionally, we present some Monte-Carlo simulations indicating that the tails are also due to Alfvén waves electron acceleration rather than quasi-static electron acceleration. Even if some details still need clarification, these observations strengthen the scenario proposed for the Io footprint and thus indicate that these processes are universal. In addition, we will present some early results from Juno-UVS concerning the location and morphology of the footprints during the first low-altitude observations of the polar aurorae. These observations, carried out in previously unexplored longitude ranges, should either confirm or contradict our understanding of the footprints. [less ▲]

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See detailQualité des médicaments antipaludéens et caractéristiques des pharmacies des territoires périurbains de Kinshasa
Mavungu Landu, Don Jethro ULg; Liégeois, Sophie; Manzambi Kuwekita, Joseph ULg et al

Poster (2016, December 14)

Contexte: Le paludisme causé par le Plasmodium falciparum demeure un problème majeur de santé publique. Le traitement avec des antipaludiques de bonne qualité est une composante importante dans le ... [more ▼]

Contexte: Le paludisme causé par le Plasmodium falciparum demeure un problème majeur de santé publique. Le traitement avec des antipaludiques de bonne qualité est une composante importante dans le contrôle de cette maladie. Cependant en Afrique centrale, plus de 25% des médicaments serait contrefaits ou de qualité inférieure, situation qui serait encore plus dramatique dans les territoires périurbains. Méthode: Dans le contexte ci-mentionné, une étude préliminaire et prospective a été menée dans la zone de santé de Mont Ngafula 1 située dans les territoires périurbains de la Ville de Kinshasa durant la période allant du 22 février au 17 mars 2016. Treize échantillons de poudre pour suspension d’artéméther et de luméfantrine ont été collectés. L’analyse de la qualité de ces médicaments a été réalisée au moyen de méthodes séparatives génériques utilisant la technique de chromatographie liquide à haute performance couplé à un détecteur à barrettes de diodes. Une caractérisation a été également effectuée dans 127 établissements pharmaceutiques sur base des normes édictées par le Ministère de la Santé Publique congolais. Résultats: Les résultats des analyses des échantillons d’antimalariques (ou antipaludéens) montre que presque la moitié des poudres pour suspension d’artéméther et de luméfantrine ne contenait pas la concentration prévue en artéméther et/ou en luméfantrine. Par ailleurs, le résultat des observations évoque qu’aucun établissement pharmaceutique ne respecte l’ensemble des normes du Ministère de la Santé Publique. [less ▲]

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See detailSolar electrons observed in the magnetosphere
Shi, Quanqi; Wang, linghua; Zong, Qiugang et al

Poster (2016, December 12)

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See detailSmart Cities. Ingénierie des usages et co-conception : un nouveau cadre pour le développement durable des bâtiments et villes intelligents.
Schelings, Clémentine ULg; Elsen, Catherine ULg

Poster (2016, December 12)

Ce projet de recherche aborde le défi de l'opposition des utilisateurs finaux à certains des concepts clés de la ville intelligente (Smart City), et plus spécifiquement leur faible niveau d'engagement vis ... [more ▼]

Ce projet de recherche aborde le défi de l'opposition des utilisateurs finaux à certains des concepts clés de la ville intelligente (Smart City), et plus spécifiquement leur faible niveau d'engagement vis-à-vis du développement de leurs bâtiments intelligents. L'acceptation des utilisateurs finaux ayant une influence déterminante sur le taux d'échec / de réussite du projet Smart City en tant que tel, cette recherche se fonde sur l'expertise des concepteurs de la Smart City (architectes, ingénieurs architectes; ingénieurs en construction, ingénieurs en développement urbain et environnement, ...) et suggère qu'une partie de la solution relève de l'interaction que ces acteurs peuvent avoir avec les utilisateurs finaux au cours des phases préliminaires du processus de construction d'un projet. La recherche vise à développer des cadres théoriques dédiés (i) à l'ingénierie des usages et (ii) au processus de co-conception, de manière à outiller les concepteurs avec des modèles théoriques, des méthodes de travail et des outils adaptés pour (i) la capture et l'analyse des comportements des utilisateurs finaux et (ii) l'investissement actif des utilisateurs finaux au sein des processus de conception de bâtiments intelligents et de leurs modèles d'occupation intelligente. [less ▲]

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See detailRenverser la machine: de la technique comme outil d’exploitation à la technique comme moyen de régénération environnementale: l’approche paysagère comme préalable à la réhabilitation des sites industriels désaffectés dans la Province de Liège.
Baldin, Elisa ULg

Poster (2016, December 12)

A partir de l’interaction entre pensée architecturale et dynamique de l’environnement, la recherche touche les problématiques de régénération des sites industriels désaffectés du bassin liégeois en ... [more ▼]

A partir de l’interaction entre pensée architecturale et dynamique de l’environnement, la recherche touche les problématiques de régénération des sites industriels désaffectés du bassin liégeois en mettant à l’épreuve le principe de « recyclage » architectural et paysager. Le site Espérance Longdoz, à Seraing, représente, en tant qu’objet de mon travail de fin d’études, un cas spécifique mais indicatif d’un phénomène territoriale, qui concerne la Vallée de la Meuse. Le projet d’aménagement urbain, où le re-dessin de l’espace se fonde sur une re-interprétation des traces existantes, ouvre à une réflexion sur la complémentarité des éléments artificiels et des éléments naturels dans le projet de régénération urbaine. L’approche paysagère intégrée est proposée comme outil pour activer des nouveaux cycles de vie, selon une dynamique écologique fondée sur la continuité à trouver entre ressource et déchet: une alternative à l’abandon et à la disparition des lieux qui ont construit l’histoire sociale et l’identité du territoire. Lectures et observations des mutations morphologiques, complétées par des analyses comparatives entre expériences locales et européennes similaires concernant des réalisations, projets en cours et acteurs engagés, fondent une réflexion critique centrée sur le renversement du sens de la machine: autrefois celle qui a exploité et bouleversé les équilibres de la terre et aujourd’hui à l’opposé, celle qui se développe et transforme les milieux à travers temporalités et actions naturelles. La thèse explore les technologies soft, de phyto-dépollution ou autre procédés de transformation naturelle, à réinsérer dans le processus de mutation de nos milieux de vie comme un système de structures d’assainissement environnemental et comme un ensemble de stratégies de reconstitution d’un paysage productif urbain/périurbain, capables de réactiver des moyens soutenables aptes à « renverser la machine » d’exploitation industrielle. [less ▲]

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See detailXenogeneic graft-versus-host disease: Impact of Th17 cells.
Delens, Loïc ULg; SERVAIS, Sophie ULg; Vrancken, Louise et al

Poster (2016, December 08)

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See detailIntegrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
Emmanuel, Noémie ULg; Mendoza Gallego, Carlos ULg; Lismont, Marjorie ULg et al

Poster (2016, December 08)

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side ... [more ▼]

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side-reactions or product degradation due to overexposure. The recent implementation of photochemical processes in microreactors under continuous-flow conditions appeared to be much more powerful than its batch analogue in terms of irradiation efficiency and light penetration. Furthermore, the fine control of residence time ensures an accurate control of the irradiation time, avoiding side-reactions and degradation. The photooxidation of (L)-methionine with singlet oxygen using Rose Bengal as a sensitizer was successfully implemented in a microreactor setup and led to total and selective conversion into methionine sulfoxide, an important building block for the organic synthesis of peptides or functionalized amino acid. The reaction was performed in 2 min while the same reaction in batch took 2h. [less ▲]

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See detailFACILITER L'ADHÉRENCE AU TRAITEMENT IMMUNOSUPPRESSEUR CHEZ LES TRANSPLANTÉS DU REIN- TEST D'UN SYSTEME DE COACHING PAR SMARTPHONE
Saint-Remy, Annie ULg; Spiroux, Marie; WEEKERS, Laurent ULg et al

Poster (2016, December 08)

Facilitate adherence to immunosuppressive treatment in kidney transplant recipients – test of a coaching system with smartphone application A.Saint-Remy, M. Spiroux, L. Weekers, C. Bonvoisin, JM ... [more ▼]

Facilitate adherence to immunosuppressive treatment in kidney transplant recipients – test of a coaching system with smartphone application A.Saint-Remy, M. Spiroux, L. Weekers, C. Bonvoisin, JM. Krzesinski Introduction: Nonadherence to immunosuppressants is a determining cause of graft loss. The present study tested during 1 month, the usefulness and the effectiveness of a coaching system using smartphone application (the Transplant Smartcoach®) on adherence in kidney transplant recipients. Methodology: The sample included 51 patients (28m/23w) transplanted for 1 year at least, mean age 52±12 years, mean graft survival 3.7±1 years. Each patient had a smartphone configured with its detailed treatment. Using the smartphone application, patient had to notify daily the intake of each tablet into a 2-hour window. If no notification was performed 1 hour later than the scheduled time of intake, the patient was contacted by a nurse to remind him to take medications. Results: 90 % of patients were treated with Tacrolimus and 10 % with cyclosporine, associated with mycophenolic acid (41 %) or mycophenolate mofetil (49 %), 41 % had corticosteroids. Whatever was the immunosuppressant, a perfect adherence (medications taken at the scheduled time) was observed on average in 53 % of the morning monthly intakes. There was no difference in adherence rates between the morning intakes of Advagraf ® (once/day) and Prograft® (2 times/day), a decrease of perfect adherence was identified with the evening intake of Prograft® (53 % vs 44%; P=0.07) and the one of Myfortic® (P=0.03) with consequently an increased frequency of nurse’s recalls. Adherence was lower in younger patients and in those still working. The complexity of treatment (many drugs intake/day) and the respect for time intervals between drug intakes were the major barriers to adherence. When compared to the one measured before using the Smartcoach, the variability (coefficient of variation, %) of the Tacrolimus trough level decreased by 32.6 % (P=0.027) in the 3 to 6 months following the test. Conclusion: patients appreciated the ease and usefulness of the coaching system with smartphone application to help medication adherence. Coupled with therapeutic education of the patients, that tool deserves to be used notably in newly transplanted patients and when a worrying decrease in adherence is observed to help them in the management of a rigorous adherence which should contribute to graft survival. [less ▲]

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See detailImplication of Importin-8 in mouse brain development
Nganou, Gerry ULg; Coumans, Bernard ULg; De Nijs, Laurence et al

Poster (2016, December 06)

Importin-8 (IPO8) is a protein that regulates the nucleocytoplasmic transport of some proteins important for cerebral development (Ago2, c-Jun, Smad4). In HEK cells, IPO8 seems to not plays others roles ... [more ▼]

Importin-8 (IPO8) is a protein that regulates the nucleocytoplasmic transport of some proteins important for cerebral development (Ago2, c-Jun, Smad4). In HEK cells, IPO8 seems to not plays others roles (like mitotic spindle formation, primary cilium transport). In situ hybridization performed in mouse brains slices shows that IPO8 is already expressed at E14. Moreover, inhibition of its action (IPO8) in embryonic mouse brain leads to impairment of neuroblast migration to upper cortical layers. IPO8 could then be at the origin of some pathologies with neuronal migration deficit. [less ▲]

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See detailOviposition deterring effect of Ocimum basilicum L. (Lamiaceae) on Tuta absoluta Meyrick (Lepidoptera: Gelechiidae)
Yarou, Boni Barthélémy ULg; Bawin, Thomas ULg; Boullis, Antoine ULg et al

Poster (2016, December 02)

Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most important pests of tomato, reducing crop yield in greenhouses and fields, in several countries around the world. Because synthetic ... [more ▼]

Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most important pests of tomato, reducing crop yield in greenhouses and fields, in several countries around the world. Because synthetic insecticides lead to resistance and have adverse effects on natural enemies and producers’ health, there is a need for alternatives. In this study, we assess the oviposition deterring effect of O. basilicum using dual-choice behavioral assays performed in flight tunnels. Two modalities were tested, i.e. (1) a tomato plant associated either with an O. basilicum plant versus a tomato plant associated with a plastic pot only filled with potting soil, and (2) a tomato plant with basil essential oil (EO) formulated in paraffin oil (PO) versus a tomato plant with PO only. A 1 ml cylindrical polyethylene plug loaded with 100 µl of solution (formulated EO or PO) was placed on each plant as a diffuser. Forty-eight hours after the release of unsexed adult individuals randomly sampled from the rearing in the central area of the tunnel, we found that plants and EOs reduced T. absoluta oviposition behavior on a nearby located tomato plant. GC-MS analyses showed that the major constituents include estragol (73.8%), linalool (8.6%), β-elemene (2.9%) in O. basilicum essential oils and E-α-bergamotene (38.9%), methyl eugenol (26.1 %), E-β-ocimene (17.7 % ) in O. basilicum VOCs collected with solid-phase micro-extraction method. These results suggest a valuable potential of O. basilicum and associated essential oils as component of an integrated management strategy against the tomato leafminer. [less ▲]

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See detailGeneralized Pascal triangles and binomial coefficients of words
Stipulanti, Manon ULg

Poster (2016, December 01)

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word ... [more ▼]

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word. Similarly to the Sierpinski gasket that can be built as the limit set, for the Hausdorff distance, of a convergent sequence of normalized compact blocks extracted from Pascal triangle modulo 2, we describe and study the first properties of the subset of [0, 1] × [0, 1] associated with this extended Pascal triangle modulo a prime p. From the extended Pascal triangle obtained when p is equal to 2, we derive a sequence of which we study the regularity and the asymptotic behavior of the summatory function. Inspired from this regularity, we extend our results to another famous numeration systems, namely the Zeckendorff numeration system. [less ▲]

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See detailLe profil en fibres alimentaires de légume modifie leur fermentation intestinale et la production d’acides gras à chaine courte dans modèle in vitro humain
Kalala Bolokango, Gaetan ULg; Kambashi Mutiaka, Bienvenu ULg; Njeumen, Patrick et al

Poster (2016, December 01)

La modulation du microbiote intestinal induite par les fibres alimentaires (DF)a des conséquences positives sur la santé, notamment sur l’obésité et ses comorbidités. La nature et l’ampleur des ... [more ▼]

La modulation du microbiote intestinal induite par les fibres alimentaires (DF)a des conséquences positives sur la santé, notamment sur l’obésité et ses comorbidités. La nature et l’ampleur des changements dépendent du type de fibres.Les légumes sont des sources privilégiées de DF, certaines espèces et variétés fournissant davantage de DF solubles (SDF), d’autres étant plus riches en DF insolubles (IDF). Contrairement aux SDF, les IDF sont souvent considérées comme peu fermentescibles, ne contribuant que faiblement à une modulation de l’écophysiologie intestinale. En opposition à cette hypothèse, pour explorer si l’impact potentiel sur la santé intestinale des légumes varie suivant leur nature, des légumes présentant des teneurs et des profils en DF différents ont été comparés dans un modèle in vitro de fermentation colique. [less ▲]

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See detailDevelopment and comparison of liposomes and nanocapsules as injectable nanocarriers for poorly aqueous soluble drugs
Karim, Reatul ULg; Palazzo, Claudio ULg; Laloy, Julie et al

Poster (2016, December)

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site ... [more ▼]

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility. [less ▲]

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See detailEtude de l’évolution de la pathologie arthrosique et des propriétés mécaniques du cartilage sur un modèle d’arthrose spontanée chez le cobaye Dunkin-Hartley
Legrand, Catherine ULg

Poster (2016, December)

Dans les modèles animaux, la gravité des lésions du cartilage est appréciée grâce à des scores histologiques évaluant la structure, le contenu en protéoglycane, l’intégrité de la tidemark, la cellularité ... [more ▼]

Dans les modèles animaux, la gravité des lésions du cartilage est appréciée grâce à des scores histologiques évaluant la structure, le contenu en protéoglycane, l’intégrité de la tidemark, la cellularité, ainsi que les ostéophytes. Parallèlement à ces analyses histologiques, nous avons étudié les propriétés mécaniques du cartilage à différents stades d’évolution de la maladie chez le cobaye Dunkin-Hartley. Nous avons également corrélé la sévérité des lésions histologiques avec les propriétés mécaniques du cartilage. [less ▲]

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See detailContinuous Monitoring of Jupiter's Aurora and Io Plasma Torus with the Hisaki Satellite during Joint Observing Campaign with Juno
Kimura, Tomoki; Yamazaki, Atsushi; Murakami, Go et al

Poster (2016, December)

The Hisaki satellite is the first space telescope that is dedicated to observations of our solar system bodies. Hisaki has been continuously monitoring the atmosphere and magnetosphere of the solar system ... [more ▼]

The Hisaki satellite is the first space telescope that is dedicated to observations of our solar system bodies. Hisaki has been continuously monitoring the atmosphere and magnetosphere of the solar system bodies with the extreme ultraviolet (EUV) spectroscope EXCEED since the launch in September 2013. Dynamics on timescales from 10s minutes to a few years were discovered in the atmosphere and magnetosphere by the continuous monitoring. Large joint observing campaigns for Jupiter by the Juno spacecraft in coordination with Hisaki, the Hubble Space Telescope (HST), and other facilities started in mid-2016. Before Jupiter Orbit Insertion, Juno made the in-situ solar wind measurements while Hisaki was simultaneously monitoring Jupiter's aurora and Io plasma torus. On Day of Year 142, Hisaki discovered that the EUV auroral emission power rapidly increased by a factor of ~3 but returned to a nominal level within one planetary rotation. The transient aurora was followed by brightening of the torus sulfur and oxygen ions that is proxy of the hot electron populations in the torus. At the same time, the relatively weak solar wind shock signatures were found in the JUNO/JEDI energetic particle data (Clark et al.). The transient variability is compared to the morphology observed by HST (Nichols et al.). Hisaki is going to monitor Jupiter in collaboration with the large observing program of HST (Grodent et al.) that will make ~150 exposures from this November. [less ▲]

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See detailUn hydrogel de chitosan d’origine non-animale restaure la fonction rhéologique du fluide synovial arthrosique : étude ex vivo
Henrotin, Yves ULg; Rocasalbas, Guillem; Chausson, Mickaël et al

Poster (2016, December)

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See detailProperties of Jupiter’s auroral acceleration region inferred with HST-STIS spectral images
Ray, Licia C.; Arridge, Christopher S.; Gustin, Jacques et al

Poster (2016, December)

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. Precipitating auroral electrons are part of a current system which transports angular momentum from the planetary ... [more ▼]

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. Precipitating auroral electrons are part of a current system which transports angular momentum from the planetary atmosphere to sub-corotating magnetospheric plasma. The magnitude of the currents and hence precipitating energy flux, are sensitive to the characteristics of the high-latitude magnetosphere, in particular the location of the auroral acceleration region (AAR) and the density and temperature of the high-latitude electron population. We use HST STIS observations of Jupiter’s aurora (Gustin et al. [2016]) to infer the location of the AAR and the properties of the precipitating auroral electrons. To do this, we determine the energy of the precipitating electrons and incident energy flux for the two distinct regions within the main aurora and within flare regions. The resulting relationships between energy flux and electron precipitation energy for the main auroral emission are then compared to the theoretical relationship derived by Lundin & Sandahl [1978], in order to derive the location of the AAR and the temperatures and densities of the electrons at the top of the AAR prior to acceleration. We find that that each emission region is best reproduced using a multiple auroral acceleration regions with different properties, rather than a single auroral acceleration region with a varying potential drop strength. [less ▲]

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See detailIntramolecular continuous-flow strategy towards methylphenidate (Ritalin) hydrochloride
Gerardy, Romaric ULg; Winter, Marc; Vizza, Alessandra et al

Poster (2016, December)

threo-Methylphenidate hydrochloride is the most widely prescribed drug to treat attention deficit hyperactivity disorder (ADHD). Herein we present the batch-to-flow translation of a carbene-based ... [more ▼]

threo-Methylphenidate hydrochloride is the most widely prescribed drug to treat attention deficit hyperactivity disorder (ADHD). Herein we present the batch-to-flow translation of a carbene-based intramolecular strategy for the diastereoselective preparation of this active pharmaceutical ingredient. The process relies on the thermal generation and decomposition of a hazardous diazospecies, its thermal intramolecular C-H insertion reaction yielding an intermediate β-lactam, and its subsequent acidic methanolysis, giving enriched threo-methylphenidate hydrochloride in 70% isolated yield. The automated microfluidic setup telescopes 2 chemical transformations, 1 intermediate in-line purification and sustains a daily productivity of 20.4 g/day of methylphenidate hydrochloride. The preparation of the β-lactam is implemented on mesoscale in a pilot-scale continuous-flow reactor, providing 4.25 kg of this key intermediate per day. [less ▲]

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See detailMultianalytical Study of “Le Sorcier d’hiva Oa” by Gauguin
Defeyt, Catherine ULg; Remon, Regine; Strivay, David ULg

Poster (2016, December)

Although there is abundant literature on the worldwide famous French painter, Paul Gauguin, very little is known concerning his painting techniques and materials. The present research aims to throw a new ... [more ▼]

Although there is abundant literature on the worldwide famous French painter, Paul Gauguin, very little is known concerning his painting techniques and materials. The present research aims to throw a new light on Gauguin’s œuvre through the in depth study of Le Sorcier d’ Hiva Oa, painted by Gauguin during his stay in French Polynesia in 1902, by means of non-invasive imaging and analytical techniques. While the infrared reflectography examination of the painting revealed how the artist achieved his final composition, the results obtained by Raman spectroscopy and X ray fluorescence spectroscopy in punctual and mapping modes allowed identifying the different pigments he combined to obtain the bright color shades characterizing this artwork. [less ▲]

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