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See detailAnother Generalization of Abelian Equivalence: Binomial Complexity of Infinite Words
Rigo, Michel ULg; Salimov, Pavel ULg

in Lecture Notes in Computer Science (2013), 8079

The binomial coefficient of two words u and v is the number of times v occurs as a subsequence of u. Based on this classical notion, we introduce the m-binomial equivalence of two words refining the ... [more ▼]

The binomial coefficient of two words u and v is the number of times v occurs as a subsequence of u. Based on this classical notion, we introduce the m-binomial equivalence of two words refining the abelian equivalence. The m-binomial complexity of an infinite word x maps an integer n to the number of m-binomial equivalence classes of factors of length n occurring in x. We study the first properties of m-binomial equivalence. We compute the m-binomial complexity of the Sturmian words and of the Thue-Morse word. We also mention the possible avoidance of 2-binomial squares. [less ▲]

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See detailMeasurement of cerebrospinal fluid albumin in healthy dogs
Ramery, Eve ULg; Girod, Maud ULg; Allerton, Fergus et al

in Veterinary Clinical Pathology (2013)

Background: Measurement of CSF albumin aids diagnosis in human medicine but technical difficulties related to its low CSF concentration prohibit its routine use in veterinary medicine. High-resolution ... [more ▼]

Background: Measurement of CSF albumin aids diagnosis in human medicine but technical difficulties related to its low CSF concentration prohibit its routine use in veterinary medicine. High-resolution electrophoresis (HRE) has been described but often results in non-interpretable integration profiles preventing albumin determination. Fraction quantification using HRE may be more precise after concentration (cHRE) using a membrane microconcentrator technique but has not been evaluated in CSF with total protein levels below 20mg/dL. Immunoturbidimetry is routinely used for human CSF albumin measurement and was recently applied on canine samples with encouraging results. Objective: The purpose of this study was to compare HRE (including the use of a concentration step) and immunoturbidimetric assay for the measurement of albumin levels in normal canine CSF. Methods: 30 CSF specimens from 15 healthy dogs were evaluated. CSF total protein was measured by the pyrogallol red methoda and CSF albumin was determined by HREb (n=15), cHREc (n=30) and immunoturbidimetric assayd (n=30). Validation of the human immunoturbidimetric assay was performed using a purified canine albumin standarde. Results: Mean CSF total protein was 17.5 (range 7-39) mg/dL. HRE integration profiles were non-interpretable in all unconcentrated specimens. However, clear distinction of the major protein fractions was achieved for all cHRE specimens. CSF albumin levels were measureable in 29/30 specimens using immunoturbidimetry. Excellent correlation (Pearson r=0.92, p<0.001) was found between the two techniques. Conclusion: Immunoturbidimetry and cHRE may be used for routine measurement of CSF albumin. [less ▲]

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See detailProcessing of Ti alloys by additive manufacturing: a comparison of the microstructures obtained by laser cladding, selective laser melting and electron beam melting
Reginster, Sylvie ULg; Mertens, Anne ULg; Paydas, Hakan ULg et al

in Materials Science Forum (2013), 765

Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the ... [more ▼]

Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the restoration - of complex and (almost) fully dense parts from Ti alloys. Both techniques involve the melting of a metallic powder with a laser. In the SLM process, the metallic powder is deposited layer by layer in a powder bed and then molten locally according to the desired shape, whereas in LC, the metallic powder is directly projected onto a substrate through a nozzle coaxial with the laser beam. The present research aims at comparing Ti-6Al-4V samples processed by these two techniques with reference samples produced by electron beam melting (EBM), another well established additive manufacturing process (patented by Arcam AB Company) in which a powder bed is molten locally by means of an electron beam. In all three processes, the melt pool undergoes an ultrafast cooling and solidifies very rapidly once the beam has left the area, thus giving rise to strongly out-of-equilibrium microstructures. Yet, each one of these processes also has its own specificities e.g. in terms of scanning strategy and of working atmosphere (low vacuum vs. protective Ar flow). In the present work, the microstructures obtained by these three processes have been compared in details, with a particular attention for characteristics such as porosity, grain size, and the various phases present. Since epitaxial growth of the newly deposited layer on the material previously solidified has been shown [1, 2] to exert a strong influence on the microstructure and on the resulting mechanical properties, great care has been taken to study the microstructural anisotropy associated with each one of the three processes. [less ▲]

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See detailHydrological and geopedological dynamics of a forested slope
Deraedt, Deborah ULg; Degré, Aurore ULg; Colinet, Gilles ULg

in Geophysical Research Abstracts (2013), 15

Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the ... [more ▼]

Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the knowledge and the modelling of this environment. Here is the aim of this study. The studied slope is located on the Houille watershed in the West of the Belgian Ardenne (50 1’47”N, 4 53’22”E) on a silty rocky soil. The site is situated under a Douglas fir (Pseudotsuga menziesii (MIRB.) FRANCO) and spruce stand cover (Picea abies (L.) Karst). It is about 160 meters long with a North-West facing slope between 7 and 55%. The goal of the study is : - to characterise the hydrological and pedogeological dynamics along a forested slope, - to compare these dynamics with the tree growth. For the geopedological part of the study, eight pits were dug to describe the soil and take some soil samples used for granulometric, chemical, etc. analysis. We have used geophysical methods (Electrical Resistivity Tomography and Ground Penetrating Radar) to estimate the soil depth. As for the hydrological part of this study, moisture sensors (capacitive and TDR) have been installed in the pits along the slope. A dye tracing test has been performed to underline the preferential flow and the importance of the subsurface flow. Several trees have been equipped with dendrometers and some measures of the LAI and the height of the trees are planned. [less ▲]

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See detailBiofilm formation on metal structured packing for the production of high added value biomolecules
Zune, Quentin ULg; Toye, Dominique ULg; Delvigne, Frank ULg et al

in Récents Progrès en Génie des Procédés (2013)

Many white biotechnology bioprocesses apply techniques from chemical engineering based on bioreactors with mechanical stirring system commonly employed in pharmaceutical sector, food industry or energy ... [more ▼]

Many white biotechnology bioprocesses apply techniques from chemical engineering based on bioreactors with mechanical stirring system commonly employed in pharmaceutical sector, food industry or energy field (Dasilva, 2004). As in chemical engineering, scale-up of these bioprocesses induces physicochemical constraints that affect physiological pathways and decrease performances. In this context, it is essential to think new bioprocesses better suited to physiology of microorganisms, minimizing physicochemical constraints. The aim of this work consists to use stainless steel structured packing (SSP) with high specific area (500-750 m²/m³) as inert support for biomass immobilization in order to produce high added value biomolecules. These bioreactors are biocatalysts in which microbial system is immobilized biomass on the form of a biofilm performing bioconversion of a substrate into a specific product (Rosche, 2009). In this study, an experimental setting containing a SSP reproduces solid-state fermentation (SSF) like conditions. Two well known microorganisms for their ability to form biofilm and secrete metabolites are tested in the experimental setting : Bacillus subtilis for its lipopeptides and Aspergillus oryzae for its glucoamylase. Effectiveness of the bioprocess in term of dynamic of the excretion of the target biomolecule is compared with a classical submerged culture (SmF). For lipopeptides production from B. subtilis, SSP is located in a 20L bioreactor continuously aspersed by liquid medium required to the growth of the biofilm. In the case of A. oryzae, the SSP is partially immerged in a 250 mL shake flask. X-ray tomography of the SSP allows non-invasive visualization and quantification of biofilm repartition inside the support. Implementation of SSP permits almost total immobilization of biomass on the form of a mono-species biofilm to the detriment of the liquid phase. Processing of images obtained by X-ray tomography of the SSP provides relevant information for the optimization of the bioprocess. For both microorganism species, results indicate the influence of parameters such as hydrodynamics, aeration rate and microorganism specificity, on the biofilm morphology inside the support and the performances of the bioprocess. SSF-like conditions in the experimental setting lead to technologic progress, such as absence of foam formation, persistence of the microbial system, and improve the dynamic of metabolites excretion compared with conditions imposed by the submerged culture. Further experiment will consider hydrodynamics aspects and amount of carbon source on effectiveness of the bioprocess. [less ▲]

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See detailAnalysis of $\alpha_s$ from the realization of quark-hadron duality
Courtoy, Aurore ULg; Liuti, Simonetta

in World Scientific (2013)

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See detailA new method for computing the derivatives of the mean and amplitude of physiological variables with respect to the parameters of a cardiovascular system model
Pironet, Antoine ULg; Dauby, Pierre ULg; Revie, James A. et al

in Minimally Invasive Therapy & Allied technologies : Official Journal of the Society for Minimally Invasive Therapy (2013), 22

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See detailDetecting correlated di-hadron pairs: about the extraction of transversity and beyond
Radici, Marco; Bacchetta, Alessandro; Courtoy, Aurore ULg

in World Scientific (2013)

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See detailRecensement des dosages d'alcool sanguin effectués dans le cadre de la sécurité routière
DEVILLE, Marine ULg; Charlier, Corinne ULg

in Acta Clinica Belgica (2013), 68(6), 479

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See detailThe spatial relationship between bone formation and bone resorption in healthy and ovariectomized mice treated with PTH, bisphosphonate or mechanical loading
Ruffoni, Davide ULg; Weigt, Claudia; Fattorini, Elisa et al

in Bone (DOI:10.1530/boneabs.1.PP437) (2013)

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See detailOleuropein or rutin consumption decreases the spontaneous development of OA in Hartley guinea pig
Sanchez, Christelle ULg; Horcajada, Marie-Noëlle; Membrez, Fanny et al

in Arthritis and Rheumatism (2013), 65

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See detailModeling of non-covalent complexes of the cell-penetrating peptide CADY and its siRNA cargo
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Deshayes, Sébastien et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 63

CADY is a cell-penetrating peptide spontaneously making non-covalent complexes with short interfering RNAs (siRNAs) in water. Neither the structure of CADY nor that of the complexes is resolved. We have ... [more ▼]

CADY is a cell-penetrating peptide spontaneously making non-covalent complexes with short interfering RNAs (siRNAs) in water. Neither the structure of CADY nor that of the complexes is resolved. We have calculated and analyzed 3D models of CADY and of the non-covalent CADY–siRNA complexes in order to understand their formation and stabilization. Data from the ab initio calculations and molecular dynamics support that, in agreement with the experimental data, CADY is a polymorphic peptide partly helical. We calculated and compared several complexes with peptide/siRNA ratios of up to 40. The initial binding of CADYs is essentially due to the electrostatic interactions of the arginines with siRNA phosphates. Due to a repetitive arginine motif (XLWR(K)), CADYs can adopt multiple positions at the siRNA surface. Nevertheless, several complex properties are common: an average of 14 ± 1 CADYs is required to saturate a siRNA. The 40 CADYs/siRNA that is the optimal ratio for vector stability always corresponds to two layers of CADYs per siRNA and the peptide cage is stabilized by hydrophobic CADY–CADY contacts. The analysis demonstrates that the hydrophobicity, the positive charges and the polymorphism of CADY are mandatory to make stable the CADY–siRNA complexes. [less ▲]

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See detailInteraction of fengycin with stratum corneum mimicking model membranes: a calorimetry study
Nasir, Mehmet Nail ULg; Eeman, Marc; Olofsson, Gerd et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 168

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See detailL’incendie : feu purificateur ?
Close, Florence ULg

in Bulletin de la Société d'Art et d'Histoire du Diocèse de Liège (2013), LXX

Dans la nuit du 3 au 4 août 1312, la Cité de Liège est mise à feu et à sang. Sept siècles plus tard, la mémoire collective liégeoise compte encore cet évènement au nombre des jalons les plus tragiques de ... [more ▼]

Dans la nuit du 3 au 4 août 1312, la Cité de Liège est mise à feu et à sang. Sept siècles plus tard, la mémoire collective liégeoise compte encore cet évènement au nombre des jalons les plus tragiques de l’histoire de la Principauté. Les conditions dans lesquelles moururent les patriciens demeurent inqualifiables, de même que les moyens auxquels recourut la masse populaire révoltée pour venir à bout de son adversaire. Cet évènement anecdotique au regard de la grande histoire met en lumière la place ambivalente du feu dans la vie et la mentalité des hommes et des femmes du Moyen Âge. Il invite à une profonde réflexion mêlant des considérations juridiques, spirituelles, symboliques et anthropologiques [less ▲]

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See detailReduction in VAP incidence by subglottic secretion drainage and antibiotic consumption in ICU patients
VAN CAUWENBERGE, Isabelle ULg; ANCION, Arnaud ULg; LAMBERMONT, Bernard ULg et al

in Intensive Care Medicine (2013), 39(Suppl 2), 465-4660898

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See detailPrediction of residual stresses by FE simulations on bimetallic work rolls during cooling
Neira Torres, Ingrid ULg; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in Computer Methods in Materials Science (2013), 13(1), 84-91

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic ... [more ▼]

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic roll studied in this paper is obtained from a vertical spin casting process followed by cooling and subsequent heat treatments. Failure of the compound roll sometimes occurs during the cooling stage of the casting route or later during the thermal treatments. It requires to deeply investigate the thermo mechanical metallurgical interactions generated during cooling and heat treatment in order to find the origin of cracks. For this purpose, a thermo metallurgic mechanical finite element model is used. However these numerical simulations require a high amount of mechanical, thermal and metallurgical parameters. In order to determinate these parameters, a study of available data for estimation of mechanical parameters was performed. Thermo physical parameters were obtained by DTA and DSC methods. Metallurgical characterization by inverse numerical method based on available CCT diagrams was performed to determine the TTT diagrams. First cooling numerical simulations are presented, allowing a rough estimate of residual stresses values and the identification of key parameters for predicting accurate residual stresses by sensitivity analysis. [less ▲]

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See detailComparing Co-Parenting Among Gay- and Straight-Parented Triads
D'Amore, Salvatore ULg; Miscioscia, Marina ULg; Delvoye, Marie

in Psychology, Community & Heath (2013), 2(2), 87-88

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See detailBlood lead, urinary lead, urinary δ-aminolevulinic acid and urinary porphyrins levels among people living in kinshasa, D.R. Congo : a pilot biomonitoring study
Mputu Malolo, Corneille-Liévin; Ndelo di Phanzu, Josaphat; Marini Djang'Eing'A, Roland ULg et al

in Acta Clinica Belgica (2013), 68(6), 475

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See detailPhenomenology of $\alpha_s$ at intermediate energy: the quark-hadron duality approach
Courtoy, Aurore ULg

in PoS - Proceedings of Science (2013)

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See detailThe Future of the Past: Architectural Heritage Guides as Handbooks for City Decoding and as a Blueprints for Urban design
Occhiuto, Rita ULg; De Fijter, Arie; Hautecler, Paul-Christian ULg

in Actes du Colloque (2013)

The recent UNESCO Recommendations on the historic hurban landscape insist on the opportunity to "shift from an emphasis on architectural monuments primarly" towards "a landscape approach" including "the ... [more ▼]

The recent UNESCO Recommendations on the historic hurban landscape insist on the opportunity to "shift from an emphasis on architectural monuments primarly" towards "a landscape approach" including "the broader urban context and its geographical setting", to understand historic urban landscape "as the result of a historic layerling, and to create new tools to adress this vision". Along this line of thought of thought, the proposed approach expands the traditional contents of architectural guides, providing keys to reconsider and evaluate the listed works' contribution to the evolution of their immediate surrounding, to the urban structure as a whole, up to the territorial scale. Moving from a design-oriented perspective and using the methods of urban morphology, the work consists mainly of set of original schemes, maps and drawings of Liège and its neighborhoods, as means to reveal the urban structure, its layerling over time, and the role of architectural heritage in clarifuing, enhancing, or even degrading the coherence of the urban artifact. Halfway between popular and scholarly literature, the forthcoming guides aim to become at both times "handbooks for city decoding" and blueprints for urban design. Providing tools lo read, comprehehen, and appreciate the part played by built heritage in a city's evolution and in the shaping of our daily environment helps to understand urban environments as a process bearing the overlapping influences of many experiments, partially implemented plans, competing visions and contradictory ideas. As a result, both the ordinary and specialized audience can possibly raise their awareness and perception of modernist architecture's legacy, but also learn how certain qualities were achieved and how certain local issues came about, acquiring relevant critical keys to take part as stakeholders or designers in the debate over the future city. [less ▲]

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See detailSTOP BANG but not BMI predicts postoperative obstructive apnoea and hypoxaemia after laparoscopic upper-abdominal surgery: 5AP2-5
Pirenne, S.; HANS, Grégory ULg; Joris, J. et al

in European Journal of Anaesthesiology (2013), 30

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See detailBehavioural Ecology of Bonobos (Pan paniscus) in the Forest-Savannah Mosaics of Western Democratic Republic of Congo
Vimond, Marie; Serckx, Adeline ULg; Beudels-Jamar, Roseline et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013)

The long-term survival of the Endangered bonobo (IUCN, 2012) will depend on well thought out conservation programmes that need to be built both upon the species’ ecological requirements and local socio ... [more ▼]

The long-term survival of the Endangered bonobo (IUCN, 2012) will depend on well thought out conservation programmes that need to be built both upon the species’ ecological requirements and local socio-economics realities. Yet there is still a lot to find out, including information on the species geographical distribution. In 2005, the presence of a western population was confirmed in the forest-savannah mosaic in the south-western part of the Lake Tumba Landscape. With the exception of an early study carried out in Lukuru, the species is mainly known from lowland rainforest research sites in the Cuvette Centrale. The western forest-savannah mosaic is an ecotone with a marked seasonal pattern, a high variability of habitats and monthly variations in fruit production. All this leads to spatio-temporal variation of food availability. In order to increase studies and monitoring of this unique population, WWF initiated a habituation process of two groups of bonobos 6 years ago. The groups are now semi-habituated, making the collection of direct daily observations possible. Our objective is to describe the behavioural strategies developed by this population in order to cope with spatio-temporal variations of food availability. This will be approached by identifying daily activity, ranging and grouping patterns, in order to understand how they affect social structure. It should also allow us to define the use of savannahs. Our findings will help determine specific conservations measures for this endangered species. [less ▲]

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See detailEffect of abrupt preload reduction on left atrial and ventricular pressures in a multi-scale mathematical model of the cardiovascular system
Pironet, Antoine ULg; Dauby, Pierre ULg; Kosta, Sarah ULg et al

in European Heart Journal Supplements : Journal of the European Society of Cardiology (2013), 34

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See detailPreliminary data on plicathyridines (Brachiopoda) from the Frasnian of southern Belgium and the Middle East (Afghanistan, Iran)
Mottequin, Bernard ULg; Marion, Jean-Marc ULg; Brice, Denise

in Documents de l’Institut Scientifique (Rabat) (2013), 26

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See detailBolero-6:Phase 2 Study of Everolimus plus Exemestane versus Everolimus or Capecitabine Monotherapy in HR+HER2- Advanced Breast Cancer
Ejlerstsen, Bent; JERUSALEM, Guy ULg; Hurvitz, Sara et al

in Journal of Clinical Oncology (2013), 31

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See detailOptimizing scale search in species distribution models
Serckx, Adeline ULg; Huynen, Marie-Claude ULg; Beudels-Jamar, Roseline et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of ... [more ▼]

The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of global change. In many studies the influence of a predictor on a response derived over multiple and discrete spatial scales is evaluated. Due to inherent issue of multiple testing, this approach can be problematic. In this study on bonobos distribution, we suggest a 3-steps procedure that overcomes this problem. It takes into account the decay of a predictor by using a weighting function of distance to the observation of interest. We use variables to account for human pressure, food availability, patchy structure of the forest and nesting sites re-use. In a first step, we run a model with a fixed scale for every predictor based on expert opinion. For significant variables, we derive then in a second step the distance weighted influence over a range of scales. This helps to narrow down the search for the final model parameter estimates. Findings indicate that bonobo distribution is driven on the intermediate scale by forest patches structure. Food availability explains their abundance only at smaller scales. Those results demonstrate the sadly well-known influence of habitat fragmentation on animals’ density and distribution but also highlight the importance to understand influences of scale, the animal perceptions of their environment, by using appropriate statistical procedures. Our method can be particularly useful to formulate specific management hypotheses for conservation. Furthermore, its principles can be of use to other types of studies, such as behavior. [less ▲]

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See detailSterile neutrinos and $R_K$
Vicente, Avelino ULg

in Journal of Physics: Conference Series (2013), 447

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See detailCorrelation between RNA and protein levels in a large european series from the LYSA
Bossard, C.; Dobay, M.P.; Lamant, L. et al

in Hematological Oncology (2013), 31 Suppl.1

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of ... [more ▼]

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of INO plus R-CVP in patients (pts) with relapsed/refractory CD22+ B-NHL. Efficacy data were also collected. Methods: Part 1 of this open-label study identified a maximum tolerated dose (MTD) of INO 0.8mg/m,2 on day 2 plus R-CVP (rituximab 375mg/m,2 cyclophosphamide 750mg/m,2 and vincristine 1.4mg/m,2 on day 1; prednisone 40mg/m,2 on days 1-5) every 21 days. Subsequently, pts were enrolled in the MTD confirmation cohort (part 2, n = 10), which required a dose-limiting toxicity rate of <33% in cycle 1 and <4 pts discontinuing prior to cycle 3 due to an adverse event (AE) in the MTD expansion cohort (part 3, n = 22), which explored preliminary activity. Results: Parts 2 and 3 enrolled 32 pts: 16 pts with diffuse large B-cell lymphoma, 15 with follicular lymphoma and one with mantle cell lymphoma. Median age was 64.5 years (range 44-81 years); 34% of pts had 1 prior regimen, 34% had 2, 28% had ≥3 and 3% had none (median 2; range 0-6).Median treatment duration was five cycles (range 1-6). Part 2 confirmed the MTD as standard dose R-CVP plus INO 0.8mg/m,2; 2/10 pts had a dose-limiting toxicity (grade 3 increased ALT/AST, grade 4 neutropenia requiring G-CSF). One pt discontinued because of an AE prior to cycle 3. Common treatment-related AEs were thrombocytopenia (78%), neutropenia (66%), fatigue (50%), leukopenia (50%), nausea (41%) and lymphopenia (38%); common grade 3/4 AEs were neutropenia (63%), thrombocytopenia (53%), leukopenia (38%) and lymphopenia (31%). There was one case of treatment-related fatal pneumonia with grade 4 neutropenia. Ten pts discontinued treatment due to AEs; thrombocytopenia/delayed platelet recovery was the leading cause (grade 1/2, n = 6; grade 3/4, n = 3). Objective response rate (ORR) was 77% (n = 24/31 evaluable pts), including 26% (n=8/31) with complete response (CR); three pts had stable disease. Of the pts with follicular lymphoma, ORR was 100% (n = 15/15), including seven pts with CR. Of the pts with diffuse large B-cell lymphoma, ORR was 60% (n = 9/16), including one pt with CR. Conclusions: Results suggest that INOplus R-CVP has acceptable toxicity and promising activity in relapsed/refractory CD22+ B-NHL. The most common grade 3/4 AEs were hematologic. Follow-up for progression-free and overall survival is ongoing. [less ▲]

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See detailStrunian Rugose and Tabulate corals from Northwestern Turkey
Denayer, Julien ULg

in Document de l'Institut Scientifique, Rabat (2013), 26

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See detailPhysico-chemical and membrane-interacting properties of D-xylose-based bolaforms. Influence of the anomeric configuration
Nasir, Mehmet Nail ULg; Legrand, Vincent; Gatard, Sylvain et al

in MATEC Web of Conferences (2013), 4

Sugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the ... [more ▼]

Sugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the pharmaceutical and cosmetic fields. Until now, no detailed analyses of the physico-chemical properties of these compounds have been undertaken. Two symmetrical D-xylose-based bolaforms were chemically synthesized where the two xylose heads are linked via an acetal link to a hydrocarbon chain containing 18 carbon atoms and an unsaturation. The two bolaforms differ only by their anomeric configuration: or The bolaform exhibits interfacial properties at the air-water interface which is not the case for the . FTIR spectroscopy showed that the interactions between the bolaform and POPC, a model phospholipid, involve the carbonyl groups of the phospholipid [less ▲]

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See detailComparison of Immune Reconstitution after Hematopoietic Stem Cell Transplantation with Flu-TBI versus TLI-ATG Conditioning
Hannon, Muriel ULg; Humblet-Baron, S.; Graux, C. et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 38

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See detailSiblings and coming-out
Haxhe, Stéphanie ULg; D'Amore, Salvatore ULg

in Psychology, Community & Health (2013), 2(2), 162

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See detailStudy on the sensitivity of three oat varieties to the saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae)
Censier, Florence ULg; Chavalle, Sandrine ULg; San Martin y Gomez, Gilles et al

in Communications in Agricultural and Applied Biological Sciences (2013), 78(2), 287-292

The saddle gall midge, Haplodiplosis marginata (von Roser, 1840) is a univoltine pest of cereals which occurs in Europe. The larvae feed on stems and attractive saddle-shaped depressions, driving to ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser, 1840) is a univoltine pest of cereals which occurs in Europe. The larvae feed on stems and attractive saddle-shaped depressions, driving to important yield losses when the galls are numerous. After 40 years without any reporting, large populations of H. marginata and important damage have been observed since 2010 in wheat crops in Belgium, especially in the Flemish Polders where clay soils and intensive farming of cereals favour heavy infestations. According to some research conducted in the 1960s during the last outbreak, oat (Avena sativa L.) is known to be one of the less favourable hosts to the saddle gall midge. Our study was performed in order to assess the host sensitivity of three oat varieties currently grown in Belgium: EVITA, EFFEKTIV and FREDDY. Therefore, oat varieties were sown on infested soil in two separate enclosures in a glasshouse. In the first enclosure, only the three oat varieties were grown; in the second one, these three oat varieties were grown together with two varieties of spring wheat: GRANNY and KWS CHAMSIN. Two parameters were measured: the percentage of leaves with laid eggs, and the number of galls per stem. The percentage of leaves with eggs showed that the infestation was significantly lower on oats when they were in presence of wheat. The egg infestation was also significantly higher on wheat than on oat, which means oat is a much less favourable host plant than spring wheat for egg laying. Oat varieties were significantly different from each other regarding the number of galls per stem, but with very little damage compared to wheat. The FREDDY variety even seemed to be completely resistant to saddle gall midge, as no galls were observed although there was a similar percentage of leaves with eggs for the three oat varieties. Cropping oat could thus contribute to reduce infestations of H. marginata. [less ▲]

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See detailRisks factors for valvular regurgitations in 3499 equids: a cross-sectional study.
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Proceedings of the 2013 ACVIM Forum (2013)

Risk factors for valvular regurgitations (VR) have been suspected in equids, but no extensive epidemiologic study has been performed in a large mixed equine population. Therefore, the aim of this study ... [more ▼]

Risk factors for valvular regurgitations (VR) have been suspected in equids, but no extensive epidemiologic study has been performed in a large mixed equine population. Therefore, the aim of this study was to statistically test risk factors for VR in a large population of equids. Hospital records were reviewed for 3.499 equids, admitted at the internal medicine department of the Liege Equine Teaching Hospital between 1994 and 2011, aged ≥2 years, and which underwent thorough cardiac clinical evaluation. Of this population, 495 cases had ECG and echocardiography performed because of a clinical suspicion of cardiac disease. Chi-square test or logistic regressions (as appropriate) were used to test if breed, gender, age, body weight (BW), and co-existence of various cardiac diseases were risk factors for each VR. Moreover, the risk of development of congestive heart failure (CHF) was tested for each VR. Significance was set at p<0.05. Most of the studied animals were warmbloods, and observed prevalences were 4.4% for mitral regurgitation (MR), 2.1% for aortic regurgitation (AR), 1.7% for tricuspid regurgitation (TR), and 1.0% for pulmonary regurgitation (PR). Significant risk factors were male gender and increasing age for AR (OR=2.03, CI=1.07-4.94), and racehorses breed group and middle-age for TR (OR=4.36; CI=1.10-17.24). No effect of age or BW was demonstrated for MR. MR was the major valvular disease associated with atrial fibrillation (AF), ventricular tachyarrhythmia, PR and CHF. TR was also linked to AF, PR and CHF; but AR was not linked to CHF. In conclusion, several previously suspected risks factors for VR were confirmed statistically in this study and should be taken into account in health and athletic monitoring of horses presenting predisposing factors. [less ▲]

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women
Reginster, Jean-Yves ULg; Ellis, AG; Luo, X et al

in Osteoporosis International (2013), 24(1), 37

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See detailRisk factors for atrial fibrillation and ventricular tachyarrhythmias in 3499 equids admitted at the liege university equine hospital between 1994 and 2011
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Proceedings of the 2013 ECEIM Congress (2013)

Risk factors for atrial fibrillation (AF) and pathological ventricular tachyarrhythmias (VTA) have been suspected in equids, however little epidemiologic data exists. The aim of this study was to ... [more ▼]

Risk factors for atrial fibrillation (AF) and pathological ventricular tachyarrhythmias (VTA) have been suspected in equids, however little epidemiologic data exists. The aim of this study was to determine risk factors for AF and VTA in a large equine population. Case files of 3499 equids admitted to the internal medicine department of the Liege University Equine Teaching Hospital between 1994 and 2011were reviewed. Amongst them, 495 horses with a suspicion of a cardiac abnormality underwent ECG and echocardiography. After calculation of prevalence of AF and VTA, we tested whether breed (chi-square test) or gender, age, body weight (BW) and presence of other cardiac diseases (logistic regressions) were risk factors (significance set at p<0.05). In the studied population, prevalence of AF was high (2.3%), whereas prevalence of VTA was low (0.7%). Warmbloods and standardbreds were significantly overrepresented in AF cases. High BW was a risk factor for AF (OR=3.54; CI=1.67-7.49), whereas age was not. No effect of breed, age or BW was demonstrated for VTA. AF was observed significantly more frequently in horses presenting with moderate to severe mitral regurgitation (MR), tricuspid regurgitation, and pulmonary regurgitation, and VTA was significantly more frequent in horses with MR. Several previously suspected but not statistically demonstrated risk factors of AF were confirmed in this study and horses presenting valvular disease could be at increased risk of developing AF and VTA. [less ▲]

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See detailLocal estradiol synthesis in the brain and its implication in male and female sexual motivation of Japanese quail
de Bournonville, Catherine ULg; Schmit, Mélanie; Ball, Gregory F et al

in Trabajos del Instituto Cajal (2013)

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See detailHypovitaminosis D and osteoporosis in burn patients: are the current practices enough ?
ROUSSEAU, Anne-Françoise ULg; LEDOUX, Didier ULg; DAMAS, Pierre ULg et al

in Osteoporosis International (2013), 24(Suppl 1), 377

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See detailFirst retrievals of HCFC-142b from ground-based high resolution FTIR solar observations: application to high altitude Jungfraujoch spectra
Mahieu, Emmanuel ULg; O'Doherty, Simon; Reimann, Stefan et al

in Geophysical Research Abstracts (2013), 15

Hydrofluorocarbons (HCFCs) are the first substitutes to the long-lived ozone depleting halocarbons, in particular the chlorofluorocarbons (CFCs). Given the complete ban of the CFCs by the Montreal ... [more ▼]

Hydrofluorocarbons (HCFCs) are the first substitutes to the long-lived ozone depleting halocarbons, in particular the chlorofluorocarbons (CFCs). Given the complete ban of the CFCs by the Montreal Protocol, its Amendments and Adjustments, HCFCs are on the rise, with current rates of increase substantially larger than at the beginning of the 21st century. HCFC-142b (CH3CClF2) is presently the second most abundant HCFC, after HCFC-22 (CHClF2). It is used in a wide range of applications, including as a blowing foam agent, in refrigeration and air-conditioning. Its concentration will soon reach 25 ppt in the northern hemisphere, with mixing ratios increasing at about 1.1 ppt/yr [Montzka et al., 2011]. The HCFC-142b lifetime is estimated at 18 years. With a global warming potential of 2310 on a 100-yr horizon, this species is also a potent greenhouse gas [Forster et al., 2007]. First space-based retrievals of HCFC-142b have been reported by Dufour et al. [2005]. 17 occultations recorded in 2004 by the Canadian ACE-FTS instrument (Atmospheric Chemistry Experiment – Fourier Transform Spectrometer, onboard SCISAT-1) were analyzed, using two microwindows (1132.5–1135.5 and 1191.5–1195.5 cm-1). In 2009, Rinsland et al. determined the HCFC-142b trend near the tropopause, from the analysis of ACE-FTS observations recorded over the 2004–2008 time period. The spectral region used in this study extended from 903 to 905.5 cm-1. In this contribution, we will present the first HCFC-142b measurements from ground-based high-resolution Fourier Transform Infrared (FTIR) solar spectra. We use observations recorded at the high altitude station of the Jungfraujoch (46.5°N, 8°E, 3580 m asl), with a Bruker 120HR instrument, in the framework of the Network for the Detection of Atmospheric Composition Change (NDACC, visit http://www.ndacc.org). The retrieval of HCFC-142b is very challenging, with simulations indicating only weak absorptions, lower than 1% for low sun spectra and current concentrations. Among the four microwindows tested, the region extending from 900 to 906 cm-1 proved to be the most appropriate, with limited interferences, in particular from water vapor. A total column time series spanning the 2004-2012 time period will be presented, analyzed and critically discussed. After conversion of our total columns to concentrations, we will compare our results with in situ measurements performed in the northern hemisphere by the AGAGE network. [less ▲]

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See detailThe Enhancement of Secondary Succession by Western Lowland Gorillas (Gorilla gorilla gorilla) in a Moist Tropical Forest of Southeast Cameroon
Petre, Charles-Albert ULg; Haurez, Barbara ULg; Tagg, Nikki et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailLa Meuse comme "Barrière" ? Regards croisés sur une frontière stratégique entre la France et l'Allemagne (1870-1914)
Bechet, Christophe ULg

in Revue Belge de Philologie et d'Histoire (2013), XCI(4), 1155-1186

In the margins of the London Treaty of 1831, a secret provision – regarding the defence of the Belgian fortresses in case of a war against France by the other Powers was maintained, putting the strategic ... [more ▼]

In the margins of the London Treaty of 1831, a secret provision – regarding the defence of the Belgian fortresses in case of a war against France by the other Powers was maintained, putting the strategic burden of the old « Low Countries Barrier » of 1815 on the frail shoulders of the newly-formed Kingdom of Belgium. To the full satisfaction of the Belgian Government, this « Fortress agreement » was practically forgotten afterwards. Nevertheless, after the Franco-Prussian War of 1870-1871, a march of the French and German armies through the Meuse valley became more and more a nightmarish eventuality. As a consequence, the towns of Liège and Namur were surrounded with modern forts to check any invasion attempt by belligerents. This shift in defensive paradigm led to numerous diplomatic and military commentaries in Belgium and abroad. Meanwhile, the new railways established between Meuse and Rhin increased the strategic value of the Ardennes-Eifel area. Finally, these modifications to the border area distorted the French and German war plans. At the beginning of the twentieth century, war-planners had started to look at the Belgian Meuse valley from a completely new perspective. [less ▲]

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See detailPartonic Picture of Generalized Transverse Momentum Distributions
Liuti, Simonetta; Courtoy, Aurore ULg; Goldstein, Gary R. et al

in World Scientific (2013)

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See detailDes ambassadeurs entre Liège et Bourgogne: Pour une étude des relations diplomatiques des pouvoirs liégeois avec les ducs Valois
Masson, Christophe ULg

in Publication du Centre Européen d'Etudes Bourguignonnes (2013), LIII(2013), 51-66

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See detailExtension of the Liège Intra Nuclear Cascade model to light ion-induced collisions for medical and space applications
Leray, S.; Mancusi, D.; Kaitaniemi, P. et al

in Journal of Physics: Conference Series (2013), 420

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See detailModélisation du captage post-combustion du CO2 avec évaluation de la dégradation des solvants
Léonard, Grégoire ULg; BELLETANTE, Ségolène; Cabeza Mogador, Bruno et al

in Récents Progrès en Génie des Procédés (2013), 104

Post-combustion CO2 capture in power plants is one of the most mature technologies for a short-term and large-scale decrease of CO2 emissions while simultaneously addressing the growing global energy ... [more ▼]

Post-combustion CO2 capture in power plants is one of the most mature technologies for a short-term and large-scale decrease of CO2 emissions while simultaneously addressing the growing global energy demand. CO2 is chemically absorbed in an amine solvent that can be regenerated at higher temperature, producing a pure CO2 stream. However, the large impact of this technology on the power plant efficiency and the environmental penalty are the main drawbacks for large-scale implementation. In this work, an innovative approach combining process modeling and evaluation of the environmental penalty due to amine degradation is presented. Based on experimental results, the kinetics of solvent oxidative and thermal degradation is estimated and included in the process model developed in Aspen Plus. Using this model, the influence of operating parameters like the oxygen concentration in the flue gas or the solvent regeneration pressure is studied. This model is a first step for a multi-objective optimization of the CO2 capture process, assessing both energy and environmental penalties of this technology. [less ▲]

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See detailInfusion of CliniMACS (Myltenyi Biotec) Enriched Regulatory T Cells Delays Experimental Xenogeneic Graft-versus-Host Disease
Hannon, Muriel ULg; Lechanteur, C.; Somja, Joan ULg et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 15

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See detailKoaleszenz in Extraktionskolonnen und Abscheidern
Pfennig, Andreas ULg; Buchbender, Florian; Chuttrakul, P et al

in Chemie Ingenieur Technik (2013)

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See detailQuadripulse Repetitive Transcranial Magnetic Stimulation on Visual Cortex for Chronic Migraine Prevention: A Pilot-Trial
Sasso d'Elia, Tullia; Vigano, Alessandro; Fataki, Michel et al

in Cephalalgia : An International Journal of Headache (2013), 33(8), 49

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See detailInhibition de la sclérostine par le romosozumab chez des femmes ménopausées ayant une DMO basse : résultats de l'étude de phase 2
Brown, JP; McClung, MR; Grauer, A et al

in Revue du Rhumatisme (2013), 80(S1), 73

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See detailLe ranélate de strontium diminue la proportion de patients progressant rapidement dès la première année : une analyse post hoc de l'étude SEKOIA
Chevalier, X; Richette, P; Bruyère, Olivier ULg et al

in Revue du Rhumatisme (2013), 80(S1), 59-60

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See detailDe la Paix d'Angleur (1313) au sac de Liège (1468). Aspects des luttes socio-politiques à Liège aux XIVe et XVe siècles
Xhayet, Geneviève ULg

in Bulletin de la Société d'Art et d'Histoire du Diocèse de Liège (2013), LXX

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See detailPotential of mid-infrared spectrum of milk to detect changes in the physiological status of dairy cows
Laine, Aurélie ULg; Goubau, Amaury; Hammami, Hedi ULg et al

in Journal of Dairy Science (2013)

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See detailInfluence of lignin in Reticulitermes santonensis: symbiotic interations investigated through proteomics
Bauwens, Julien ULg; Tarayre, Cédric ULg; Brasseur, Catherine ULg et al

in Symbiosis (2013)

The gut of lower termites is populated by numerous microbial species belonging to prokaryotes, fungi, yeasts and protists. These micro-organisms are organized in a complex symbiotic system, interacting ... [more ▼]

The gut of lower termites is populated by numerous microbial species belonging to prokaryotes, fungi, yeasts and protists. These micro-organisms are organized in a complex symbiotic system, interacting together and with the insect host. Their likely ability to degrade ligno-cellulosic compounds could lead to improvements in second generation biofuels production. Lignin elimination represents a critical point as this polymer significantly interferes with industrial process of cellulose. Although host produces its own lignin-degrading enzymes, some symbionts may participate in digestion of lignin and its degradation products in termite gut. Here, we compared gut proteomes from R. santonensis after rearing on artificial diets composed of cellulose with and without lignin. The effect of lignin in artificial diets on different parts of the digestive tract was compared through liquid chromatography associated with tandem mass spectrometry (LC-MS/MS) experiments. Enzymatic assays were performed to characterize activities present in R. santonensis digestive tract after feeding on artificial diets. Microscopic observations of microbial communities provided some information on population balances after feeding experiment. [less ▲]

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See detailResearch Contributions from Lola Ya Bonobo
André, Claudine; Songrady, Judy; Serckx, Adeline ULg et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailApplication de la résonance magnétique nucléaire (RMN) en toxicologie judiciaire
Denooz, Raphaël ULg; Frederich, Michel ULg; Charlier, Corinne ULg et al

in Acta Clinica Belgica (2013), 68(6), 470

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See detailSymmetries in multi-Higgs-doublet models
Ivanov, Igor ULg; Vdovin, Evgeny

in AIP Conference Proceedings (2013)

We report the recent progress in understanding of symmetries which can be implemented in the scalar sector of electroweak symmetry breaking models with several Higgs doublets. In particular we present the ... [more ▼]

We report the recent progress in understanding of symmetries which can be implemented in the scalar sector of electroweak symmetry breaking models with several Higgs doublets. In particular we present the list of finite reparametrization symmetry groups which can appear in the three-Higgs-doublet models. [less ▲]

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See detailInitiation of methane turbulent flux measurements over a grazed grassland in Belgium
Dumortier, Pierre ULg; Aubinet, Marc ULg; Chopin, Henri ULg et al

in Geophysical Research Abstracts (2013), 15

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See detailSNR dependence of mean kurtosis and how to correct it
André, Elodie ULg; Phillips, Christophe ULg; Farrher, Ezequiel et al

in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society For Magnetic Resonance in Medicine. Scientific Meeting and Exhibition (2013), 21

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See detailValence transversities: the collinear extraction
Courtoy, Aurore ULg; Bacchetta, Alessandro; Radici, Marco

in PoS - Proceedings of Science (2013)

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See detailGrote scheppen zoete broodpap : de receptie van Hendrik Conscience in Frankrijk
Andringa, Kim ULg

in Verslagen en Mededelingen van de Koninklijke Academie voor Nederlandse Taal- en Letterkunde (2013), 123(2/3),

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See detailFinal analysis of overall survival for the Phase III CONFIRM trial: fulvestrant 500 mg versus 250 mg
DI LEO, Angelo; JERUSALEM, Guy ULg; PETRUZELKA, Lubos et al

in Cancer Research. Supplement (2012, December 15), 72(24), 1-4

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See detailDiscriminant BOLD Activation Patterns during Mental Imagery in Parkinson’s Disease
Schrouff, Jessica ULg; Cremers, Julien ULg; D'Ostilio, Kevin ULg et al

in Proceedings of MLINI 2012 (2012, December 07)

Using machine learning based models in clinical applications has become current practice and can prove useful to provide information at the subject’s level, such as predicting an (early) diagnosis or ... [more ▼]

Using machine learning based models in clinical applications has become current practice and can prove useful to provide information at the subject’s level, such as predicting an (early) diagnosis or monitoring the evolution of a disease. However, the performance of these models depends on the choice of a biomarker to detect the presence or absence of a disease. Choosing a biomarker is not straightforward, especially in the case of Parkinson’s disease when compared to healthy subjects. In the present work, we investigated the mental imagery of gait as a biomarker of Parkinson’s disease and showed that the signal in the mesencephalic locomotor region during the mental imagery of gait at a comfortable pace can discriminate significantly between idiopathic Parkinson’s disease patients and healthy subjects. Although there is room for improvement, the results of this preliminary study are promising. [less ▲]

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See detailInnovative Surface Plasmon Resonance biosensing architectures
desfours, Caroline; Hastanin, Juriy ULg; Drucbert, Anne-Sophie et al

in International Conference on Fibre Optics and Photonics (2012, December)

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological ... [more ▼]

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological molecules with a two-wavelength sensor and a SPR Coupler- Disperser spectroscopic sensor. [less ▲]

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See detailEvaluation d'un protocole de prise en charge nutritionnelle interdisciplinaire chez des patients brulés
MALHERBE, Christian ULg; VERBRUGGE, Anne-Marie ULg; MAGNETTE, André ULg et al

in Nutrition Clinique et Metabolisme (2012, December), 26-Supp1

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See detailPotentiel de dispersion du sanglier et historique de la colonisation de la plaine agricole
Morelle, Kevin ULg; Prévot, Céline

in Forêt Wallonne (2012, December), 121

Les populations de sangliers augmentent en nombre et étendent leur aire de répartition un peu partout en Europe. En Wallonie, la population de sangliers a quadruplé en 30 ans. Plusieurs études se sont ... [more ▼]

Les populations de sangliers augmentent en nombre et étendent leur aire de répartition un peu partout en Europe. En Wallonie, la population de sangliers a quadruplé en 30 ans. Plusieurs études se sont penchées sur le sujet et les raisons de cette augmentation concernent souvent l’influence du climat. Grâce aux différents suivis réalisés par le DEMNA, les déplacements au sein des populations de sangliers sont mieux compris. L’article se penche d’abord sur le potentiel de dispersion du sanglier en se basant sur les données de bagage de marcassins. Deux variables sont analysées : la distance parcourue dans le cadre de la dispersion natale (mouvement à sens unique à partir du site de naissance d’un individu jusqu’à son site de première reproduction) et le taux de cette dispersion natale. Quelques résultats provenant d’une étude génétique sont également présentés. Le génotypage de 1153 sangliers répartis sur l’ensemble de la Wallonie a mis en évidence quatre sous-populations génétiquement homogènes. Parallèlement à l’augmentation de la taille de ses populations, le sanglier a vu son aire de distribution s’accroître en Wallonie. Un suivi par enquête a été réalisé auprès des conseils cynégétiques et des agents du DNF pour mieux comprendre l’expansion géographique observée. Une première phase de l’enquête visait à retracer l’expansion géographique du sanglier en Wallonie. La seconde phase consistait à réaliser un état des lieux sur la situation actuelle de la distribution du sanglier en périphérie du sillon Sambre-et-Meuse. [less ▲]

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See detailUne étude de la vulnérabilité cognitive des parents au premier degré de patients schizophrènes
Wagener, Aurélie ULg; Duke, Géraldine; Xhenseval, Laure et al

in Revue Francophone de Clinique Comportementale et Cognitive (2012, December), XVII(4), 53

Schizophrenic patients and their first-degree relatives suffer from cognitive deficits in different area (memory, executive, attentional and language functions) which allows us to consider these deficits ... [more ▼]

Schizophrenic patients and their first-degree relatives suffer from cognitive deficits in different area (memory, executive, attentional and language functions) which allows us to consider these deficits as endophenotypes of schizophrenia. Schizophrenic patients also suffer from a lack of autobiographical memory and instability of identity: our study aims to determine whether this deficit and this instability are endophenotypes of schizophrenia. In order to reach this objective, we evaluated first-degree relatives. The results show that first-degree relatives suffer from cognitive deficits but, contrary to our hypotheses, not any deficit of specificity or instability of identity have been highlighted among these parents. [less ▲]

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See detailMeasurement of serum albumin by protein electrophoresis and bromocresol green methods in canine and equine patients
Ramery, Eve ULg; Bureau, Fabrice ULg

in Veterinary Clinical Pathology (2012, December), 41(4), 5

Background: Bromocresol green method (BCG) is routinely used in veterinary laboratories to measure albumin. A good agreement between BCG and electrophoresis (SPE) in healthy domestic animals is reported ... [more ▼]

Background: Bromocresol green method (BCG) is routinely used in veterinary laboratories to measure albumin. A good agreement between BCG and electrophoresis (SPE) in healthy domestic animals is reported. However, in human medicine, at low albumin and high globulin concentrations, BCG also binds to α- and β-globulins fractions. Surprisingly, there is no recent literature evaluating the BCG method in diseased domestic animals. Objective: The purpose of the present study was therefore to compare the serum albumin values obtained by SPE and BCG in canine and equine patients. Methods: Albumin measured by BCG and SPE was compared in the serum from 30 canine and 30 equine patients. Results: Good correlation was found (Spearman´s rho rs = 0.91 in dogs and 0.84 in horses). However, Altman and Bland analysis of results showed a positive bias of BCG with SPE (3.41 g/l in horses and 0.41 g/l in dogs) that increased when only hypoalbuminemic patients were considered (4.17 g/l in horses and 1.31 g/l in dogs). Conclusion: Results confirm that, despite good correlation, BCG method tends to overestimate albumin, especially in hypoalbuminemic patients. This is particularly evident in horses. [less ▲]

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See detail(Pré)textes : perspective didactique sur le dépeçage des textes littéraires à des fins d'exemplification
Van Beveren, Julien ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2012, December), 4

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See detailNon-thermal radiation from a runaway early-type star
del Valle, M.; Romero, G.E.; De Becker, Michaël ULg

in AIP Conference Proceedings (2012, December), 1505

HD 195592 is an O-type supergiant star, known as a well-established runaway. Recently, a Fermi γ-ray source (2FGL J2030.7+4417) with a position compatible with that of HD 195592 has been reported. Our ... [more ▼]

HD 195592 is an O-type supergiant star, known as a well-established runaway. Recently, a Fermi γ-ray source (2FGL J2030.7+4417) with a position compatible with that of HD 195592 has been reported. Our goal is to explore a scenario where HD 195592 is the counterpart of the Fermi γ-ray source. The high-energy emission would be inverse Compton radiation produced in the bowshock of the runaway star. We calculate relativistic particle energy losses and the resulting radiation from the bowshock of HD 195592 and show that the latter is compatible with the detected γ-ray emission. We conclude that the Fermi source 2FGL J2030.7+4417 might be produced, under some energetic assumptions, by inverse Compton up-scattering of infrared photons from locally heated dust. HD 195592 might therefore be the very first object detected belonging to the category of γ-ray emitting runaway massive stars, whose existence has been recently predicted. [less ▲]

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See detailDynamic simulations of solar combisystems integrating a seasonal sorption storage: Influence of the combisystem configuration
Hennaut, Samuel ULg; Thomas, Sébastien ULg; Davin, Elisabeth ULg et al

in Strojarstvo: Journal for Theory and Application in Mechanical Engineering (2012, December), 54(6), 433-440

This paper focuses on the sizing of solar combisystems with adsorption seasonal storage to target autonomous solar space heating. Two main configurations of the combisystem are simulated, including one or ... [more ▼]

This paper focuses on the sizing of solar combisystems with adsorption seasonal storage to target autonomous solar space heating. Two main configurations of the combisystem are simulated, including one or two tanks. The influence of the seasonal storage on the sizing of the tanks is also discussed. Results show that performances of the system with two tanks are better (2 to 4 % with seasonal storage) but some improvements should be possible for the single tank configuration. The sizing of the sensible storage is nearly independent of the solar collectors area if there is a seasonal storage. The sensible storage size increase with the collectors area without adsorption storage. The analysis is conducted in simulation using the TRNSYS program. [less ▲]

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See detailPatterns of Clinical Management and Resource Utilisation for Postmenopausal Hormone-Receptor-Positive HER2-Negative (HR+ HER2-) Advanced Breast Cancer (BC) in Europe
ANDRE, Fabrice; MARINSEK, Nina; RICCI, Jean-François et al

in Value in Health (2012, November), 15(7), 419

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See detailWhat is the potential increase of the heart graft pool by cardiac donation after circulatory death?
NOTERDAEME, Timothée; NELLESSEN, Eric ULg; HANS, Marie-France ULg et al

in Transplantation (2012, November), 94

Background: Heart transplantation remains to date the only definite treatment option for end-stage heart diseases. Currently only heart procured from brain death (DBD) donors are used. Combined with an ... [more ▼]

Background: Heart transplantation remains to date the only definite treatment option for end-stage heart diseases. Currently only heart procured from brain death (DBD) donors are used. Combined with an increasing demand, the constant heart graft shortage leads to an increase of deaths on cardiac transplantation waiting lists. The use of hearts procured after donation after circulatory death (DCD) could help to partly decrease the heart graft shortage. The aim of this study was to evaluate the potential increase of heart graft pool by development of DCD heart transplantation. Methods: The authors retrospectively reviewed their local donor database for the period 2006-2011, and screened the complete controlled DCD donor population for potential heart donors, using the same criteria as for DBD heart transplantation. The acceptable warm ischemic time (WIT) was limited to 30min from life support withdrawal to aortic cannulation. Results: During the analyzed timespan, 177 DBD and 70 DCD were effectively performed. From the 177 DBD, a total of 70 (39.5%) hearts were procured and transplanted locally or in another center. Out of the 70 DCD, 8 (11%) donors fulfilled the criteria for heart graft procurement and had a WIT of less than 30 minutes. During the same period, 82 patients were newly listed for heart transplantation, of which 53 were transplanted, 20 died or were unlisted, and 9 were still awaiting transplantation. Conclusions: Based on our database and a WIT of less than 30min, it could be estimated that 11% of the DCD might be heart graft donors, representing a 11% increase in heart graft procurement, as well as potential reduction of the deaths on the waiting list by 40%. [less ▲]

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See detailEvaluation de l’impact de la filiere de production porcine sur les caractéristiques des jambons de l’IGP (Indication Géographique Protégée) Jambon d’Ardenne
Dzaomuho-Lenieregue, Phidias ULg; Eloundou Mballa, Pierre ULg; Sindic, Marianne ULg et al

in Viandes et Produits Carnés (2012, November), Hors-Série

The aim of this study is to evaluate the influence of pork production sector on technological behavior of raw material, properties of the ham final product and consumer preferences. An experimental ... [more ▼]

The aim of this study is to evaluate the influence of pork production sector on technological behavior of raw material, properties of the ham final product and consumer preferences. An experimental manufacturing assay of Ardenne Ham has been conducted for this purpose. Results show few incidence of pork production conditions on technological properties and chemical or sensory characteristics of hams. The preference tests, carried out with a sensory panel using several criteria, showed that consumers were able to distinguish two groups of hams, according to their fat content. They have a preference for lower-fat ham from one of the studied sectors. Method of multicriteria decision shows no overall preference for one of the submitted ham. [less ▲]

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See detailVocal Impact of a Prolonged Reading Task in Dysphonic versus Normophonic Female Teachers
Remacle, Angélique ULg; Morsomme, Dominique ULg; Berrué, Elise et al

in Journal of Voice (2012, November), 26(6), 8201-82013

OBJECTIVES: This study evaluates the impact on voice of a 2-hour reading task between 70-75 dB(A) in 16 normophonic and 16 dysphonic female teachers with vocal nodules. METHODS: Objective measurements ... [more ▼]

OBJECTIVES: This study evaluates the impact on voice of a 2-hour reading task between 70-75 dB(A) in 16 normophonic and 16 dysphonic female teachers with vocal nodules. METHODS: Objective measurements (acoustic analysis, voice range measurements, aerodynamic measurements) and subjective self-ratings were collected before the task and every 30 minutes during the reading to determine the voice evolution in both groups. RESULTS: Fundamental frequency, lowest frequency, highest frequency (F-High), highest intensity and intensity range increase through the reading, whereas Shimmer decreases. Maximum phonation time decreases after 30 minutes. Estimated subglottal pressure (ESP) and sound pressure level increase during the first hour. Afterwards, ESP decreases. Self-ratings worsen through time. When comparing the normophonic and the dysphonic teachers, self-ratings reveal more complaints in the dysphonic group. Few differences in objective measurements are found between both groups: normophonic teachers show lower ESP, higher F-High and greater frequency range. CONCLUSIONS: Frequency modifications from acoustic analysis and voice range measurements suggest an increased laryngeal tension during vocal load, while subjects perceive a worsening of voice. Aerodynamic parameters depict first a deterioration of voice efficiency and then an adaptation to the prolonged reading. The comparison between both groups shows a discrepancy between objective measurements and self-ratings, suggesting that both approaches are necessary to have a complete view of vocal load effects. Surprisingly, both groups behave similarly through vocal load, without more or quicker deterioration of voice in the dysphonic group. [less ▲]

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See detailHighly excited states of baryons in large Nc QCD
Matagne, Nicolas; Stancu, Floarea ULg

in Bled Workshops in Physics (2012, November), 13(1), 47-53

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See detailSingle nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata.
Conteduca, Giuseppina ULg

in Clinical & Experimental Medicine (2012, November), 14(1), 91-7

Alopecia areata (AA), an autoimmune disease affecting anagen stage hair follicles, is associated with polymorphisms in immune-related genes and with decreased number of CD4+ CD25+ T regulatory cells (Treg ... [more ▼]

Alopecia areata (AA), an autoimmune disease affecting anagen stage hair follicles, is associated with polymorphisms in immune-related genes and with decreased number of CD4+ CD25+ T regulatory cells (Treg). Treg function is modulated by the forkhead box protein 3 (FOXP3) transcription factor and by inducible costimulator (ICOS), through interaction with the relative ligand, ICOSLG, whose genes are polymorphic. The aim of the study was to investigate whether specific single nucleotide polymorphisms (SNPs) of the rs2294020 FOXP3 and/or rs378299 ICOSLG genes may be associated with AA. A case-control study was performed in 120 AA patients and 84 controls. SNPs were analyzed by gene sequencing. FOXP3 and ICOSLG gene expressions were analyzed by real-time PCR. Increased frequencies of the genotype carrying the FOXP3 rs2294020-3675(A) [P = 0.002, OR (95 % CI): 2.55 (1.2-2.7)] or the ICOSLG rs378299-509(C) [P = 0.01, OR (95 % CI): 2.21 (1.1-2.6)] allelic variants were observed in AA patients than in controls. The genotype carrying the combination of the FOXP3 rs2294020-3675(A) and ICOSLG rs378299-509(C) allelic variants with the HLA DQB1*03 allele was more frequently present in AA patients than in controls (P = 0.04). The presence of the FOXP3 rs2294020-3675(A) or the ICOSLG rs378299-509(C) allelic variant was associated with reduced relative gene expression in AA patients. These data suggest that rs2294020 SNP of FOXP3 gene and rs378299 SNP of ICOSLG gene are associated with AA and with a reduced expression of the FOXP3 and ICOSLG genes in alopecia patients. [less ▲]

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See detailCouplage des modèles numériques SWAT et FeFlow pour l'étude des flux de nitrate à l'échelle d'un bassin versant agricole posé sur un aquifère sableux. Calibrage, validation et test de scénarios pour l'évaluation de pratiques agricoles plus durables en terme de gestion de l'azote
Vandenberghe, Christophe ULg; Deneufbourg, Mathieu ULg; Gaule, David et al

in Bulletin du groupe francophone Humidimétrie et Transferts en milieux poreux (2012, November), 58

Quatre prises d’eau exploitées à Arquennes (Belgique) sont contaminées par le nitrate. Leurs bassins d’alimentation sont situés en zone agricole caractérisée par un sol limoneux sur un aquifère sableux ... [more ▼]

Quatre prises d’eau exploitées à Arquennes (Belgique) sont contaminées par le nitrate. Leurs bassins d’alimentation sont situés en zone agricole caractérisée par un sol limoneux sur un aquifère sableux. Depuis 2004, ces bassins servent de site pilote dans le cadre de l’évaluation du Programme de Gestion Durable de l’Azote (PGDA), transposition de la Directive « Nitrates » en droit wallon. Les modèles numériques SWAT et FEFLOW ont permis de simuler les flux d’eau et de nitrate depuis la surface jusqu’aux galeries. Après calibrage et validation des modèles (sur la base d’une caractérisation du sol et du sous-sol et de traçages en milieux saturé et non saturé), plusieurs scénarios de pratiques agricoles ont été simulés afin de prédire l’évolution qualitative des eaux. L’expérience d’Arquennes a démontré que le recours au couplage SWAT / FEFLOW permet de proposer des solutions environnementales réalistes pour atteindre les objectifs fixés par la DCE. [less ▲]

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See detailDoes processing speed protect from age-related decline in cognitive control?
Manard, Marine ULg; Carabin, Delphine; Collette, Fabienne ULg

in Frontiers in Human Neuroscience (2012, October 27)

Age-related difficulties have been reported on proactive control whereas reactive control seems to remain intact (Braver, Gray, & Burgess, 2007; Braver, 2012). This study investigated the potential ... [more ▼]

Age-related difficulties have been reported on proactive control whereas reactive control seems to remain intact (Braver, Gray, & Burgess, 2007; Braver, 2012). This study investigated the potential influence of speed of processing abilities on the age-related decline in proactive control. We used a working memory recognition paradigm involving proactive or reactive cognitive control by manipulating the interference level across items. 80 young adults (18-29 years old) and 80 healthy older adults (60-89 years old) were included. The main results revealed significant effects of age on sensitivity to interference. As expected, reactive control performance remained intact with aging (similar interference effect in the two groups). In contrast, we observed a larger interference effect in the proactive condition in aging. Finally, when the groups are matched according to their processing speed (assessed by the Code task of the WAIS III, with both younger and older adults having a score comprised between 60 and 93), the effect of age on sensitivity to interference disappeared. In other words, when younger and older adults had similar speed of processing abilities, no age-related proactive control decline was observed. In conclusion, beyond the fact that this study confirms the selective age-related decline in proactive control, it also indicates that speed of processing, a measure considered as reflecting the integrity of cognitive functioning during aging (Salthouse, 1996), influences the efficiency of proactive control in that population. [less ▲]

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See detailMammoths used as food and building resources by Neanderthals: Zooarchaeological study applied to layer 4, Molodova I (Ukraine)
Demay, Laëtitia ULg; Péan, Stéphane; Patou-Mathis, Marylène

in Quaternary International (2012, October 25), 276-277(25 October 2012), 212-226

Considering Neanderthal subsistence, the use of mammoth resources has been particularly discussed. Apart from procurement for food, the use of mammoth bones as building material has been proposed. The ... [more ▼]

Considering Neanderthal subsistence, the use of mammoth resources has been particularly discussed. Apart from procurement for food, the use of mammoth bones as building material has been proposed. The hypothesis was based on the discovery made in Molodova I, Ukraine (Dniester valley). In this large multistratified open-air site, a rich Mousterian layer was excavated. Dated to the Inter-Pleniglacial (MIS 3), it has yielded 40 000 lithic remains associated with ca. 3000 mammal bones, mostly from mammoth. Several areas have been excavated: a pit filled with bones, different areas of activities (butchering, tool production), twenty-five hearths and a circular accumulation made of mammoth bones, described as a dwelling structure set up by Neanderthals. Attested dwelling structures made of mammoth bones are known in Upper Paleolithic sites, from Ukraine and Russia, attributed to the Epigravettian tradition. This paper presents a zooarchaeological study of large mammal remains from Molodova I layer 4, to understand the modalities of acquisition and utilization of mammoth resources for food and technical purposes, especially to test the hypothesis of using bones as building elements. The number of mammoths is estimated to at least fifteen individuals of all age classes and both sexes, which died during several episodes, near or on the site. The taphonomic modifications due to weathering, water percolation and plant roots indicate the location of bones in holes, such as the pit and the basement of the circular accumulation. Secondary actions of carnivores, especially of hyaenid type, are rare on bones, showing that the assemblage was not accumulated by these predators. The anatomical preservation, the age and sex features and the taphonomic data indicate several modalities of mammoth acquisition by hunting, scavenging and collecting. Based on anthropogenic marks, mammoth meat has been eaten. The presence of series of striations and ochre on mammoth bones are associated with a technical or symbolic use. Furthermore, mammoth bones have been deliberately selected (long and flat bones, tusks, connected vertebrae) and circularly arranged. This mammoth bone structure could be described as the basement of a wooden cover or as a wind-screen. The inner presence of fifteen hearths, lithic artifacts and waste of mammal butchery and cooking is characteristic of a domestic area, which was probably the centre of a residential camp recurrently settled. It appears that Neanderthals were the oldest known humans who used mammoth bones to build a dwelling structure. [less ▲]

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