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See detailStratégies spécialisées d’acquisition de pigments rouges durant le Châtelperronien de la grotte du Renne à Arcy-sur-Cure (Yonne, France)
Salomon, Hélène ULiege; Coquinot, Yvan; Beck, Lucile et al

in Paléo (2014), Special issue

Depuis une décennie, les découvertes de matériaux colorants se multiplient parmi les sites dont les occupations remontent au Paléolithique moyen et au Paléolithique supérieur ancien. L’intérêt qu’elles ... [more ▼]

Depuis une décennie, les découvertes de matériaux colorants se multiplient parmi les sites dont les occupations remontent au Paléolithique moyen et au Paléolithique supérieur ancien. L’intérêt qu’elles suscitent tient à ce qu’elles sont susceptibles de révéler des pratiques techniques diverses et complexes, mais il tient aussi à leur forte potentialité à traduire des pratiques symboliques du fait de leur pouvoir colorant intense et des couleurs exploitées : le rouge et le noir. C’est sur le gisement châtelperronien de la grotte du Renne à Arcy-sur-Cure (Yonne), fouillé de 1949 à 1963 par André Leroi-Gourhan, qu'environ 2000 matières colorantes découvertes ont conduit à échafauder des théories concernant leurs transformations et leurs utilisations qui méritaient d’être éprouvées. Il est supposé, depuis leur découverte, qu’elles ont fait l’objet d’un chauffage contrôlé qui visait à en modifier la couleur, le chauffage permettant de transformer les matières colorantes jaunes (hydroxydes de fer) en orangé, en rouge et en violacé (oxydes de fer). De cette hypothèse découle la théorie selon laquelle les Néandertaliens ont exploité les matières colorantes en tant que pigment pour des réalisations symboliques, voire d’ordre esthétique, ce qui n’a pas encore pu être prouvé. La présente étude, fondée sur le croisement des données issues des analyses de la nature physico-chimique et pétrographique des assemblages de matières colorantes, mais aussi sur leur intégration dans le gisement, en association avec des structures d’habitat dont la conservation est exceptionnelle, et sur une série d’expérimentations visant à caractériser les poudres obtenues par différents moyens a permis de définir les choix techniques qui ont présidé à l’approvisionnement en matières colorantes dans tous les niveaux d’occupation châtelperroniens de la grotte du Renne. Il a ainsi été possible de démontrer qu’aucune des matières colorantes, rouges ou noires, n’a fait l’objet d’un chauffage préalablement à son utilisation, bien au contraire de ce qui avait été supposé jusqu’ici. Ces matières colorantes ont fait l’objet d’un approvisionnement raisonné auprès de formations géologiques affleurant ponctuellement. L’exploitation de ces gîtes de matières premières colorantes a été la même durant toute la séquence châtelperronienne et s’est orientée préférentiellement vers des matériaux que l’on peut aisément réduire en poudre. L’assemblage des matières colorantes de la grotte du Renne révèle à la fois une permanence des pratiques techniques et culturelles qui ont trait à l’emploi de matières colorantes et un profond ancrage des connaissances et de la compréhension des multiples propriétés et qualités de ces matériaux intensément mises à profit dans des activités diverses, domestiques, artisanales et manifestement aussi d’ordre symbolique, de telle sorte que le gisement châtelperronien était tout de rouge et noir. [less ▲]

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See detailAnalyse non destructive des pigments préhistoriques : du laboratoire à la grotte
Beck, Lucile; Lebon, Matthieu; Lahlil, Sophia et al

in Paléo (2014), special issue

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See detailLa loutre en France et Navarre
Pigneur, Lise-Marie; Marc, Daniel; Fournier, Pascal et al

in Bulletin de liaison des Mammalogistes de Midi-Pyrénées (2014)

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See detailCx30 (GJB6) inhibits cell growth in human malignant gliomas but mediates radiation resistance
Artesi, Maria ULiege; Kroonen, Jerome; Poulet, Christophe ULiege et al

in Neuro-Oncology (2014)

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat ... [more ▼]

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat glioma cells. Here we report that a Cx30 gene deletion occurs in approximately 30% of human glioblastomas (GBMs). Cx30 mRNA levels are decreased in these tumors compared to glial tumors of lower grade and to non tumoral tissues. At the protein level, Cx30 is lost in approximately one third of the tumors in our cohort of 230 glioblastoma biopsies. Restoration of Cx30 in U87 glioma cell lines and in glioma primary cultures (GM1), effectively retards cell proliferation in vitro and inhibits tumor growth in vivo. This correlates with a decrease in TCF, CK2 and NFkappaB activity and with altered expression levels of cell cycle control proteins such as cyclin D1, P27, P21 and c-myc. In patient biopsies, Cx30 expression was found in tumor regions displaying a lower Ki-67 proliferative index. Interestingly, in our cohort of malignant glioma patients, Cx30 expression proved to be an adverse prognostic factor. Here, we demonstrate its role in mediating cell survival and a hypermetabolic state after radiation treatment in human glioma cells. Mechanistically, we propose that a HSP90- mediated Cx30 translocation into mitochondria occurs after radiation treatment. The inhibition of the HSP90 molecular chaperone with geldamycin inhibits the radiation- induced translocation of Cx30 into mitochondria, decreasing the hypermetabolic state and restoring radiation sensitivity in those cells. These results demonstrate the central regulatory role of connexin30 in the biology of human gliomas. [less ▲]

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See detailToward modelization of quark and gluon transversity generalized parton distributions
Pire, Bernard; Semenov-Tyan-Shanskiy, Kirill ULiege; Szymanowski, Lech et al

in PoS - Proceedings of Science (2014), PoS DIS2014

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See detailπN TDAs from charmonium production in association with a forward pion at PANDA
Ma, Binsong; Pire, Bernard; Semenov-Tyan-Shanskiy, Kirill ULiege et al

in EPJ Web of Conferences (2014), 73

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See detailDétection de l'hémoglobinurie paroxystique nocturne par cytométrie en flux : Validation
Louis, Céline; FOGUENNE, Jacques ULiege; KEUTGENS, Aurore ULiege et al

in Revue de l'Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2014), 41(3), 240

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See detailDistribution des propriétés morphologiques et chimiques d’un sol le long d’un versant forestier
Deraedt, Deborah ULiege; Degré, Aurore ULiege; Colinet, Gilles ULiege

in Revue Forestière Française (2014), 2014(4),

Plant productivity is partly dependent on soil fertility, which is why it is important to know the distribution of the chemical and morphological properties of the soil. The study was conducted at an ... [more ▼]

Plant productivity is partly dependent on soil fertility, which is why it is important to know the distribution of the chemical and morphological properties of the soil. The study was conducted at an experimental site located on a steep forested slope planted with conifers. Consequently, prior to the study of variations in soil and vegetation characteristics over time, we analysed the chemical and morphological properties along the slope. Eight pits were dug and sampled by horizon. Root density, bulk density and stone content measurements were performed as well as the analysis of the soil chemical properties (pH, K, Mg, Na, Ca and P content). The results confirm the significance of vertical differentiation as one moves along the profile. [less ▲]

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See detailIm Labyrinth der eigenen Lebensgeschichte. Krankheit und Erzählen in Wilhelm Raabes "Holunderblüte" und Theodor Storms "Ein Bekenntnis"
Leyh, Valérie ULiege

in Jahrbuch der Raabe-Gesellschaft (2014)

Les nouvelles "Holunderblüte" (1863) de Wilhelm Raabe et "Ein Bekenntnis" (1887) de Theodor Storm allient psychologie, maladie et narration. Les deux textes racontent l’histoire de médecins qui à la fin ... [more ▼]

Les nouvelles "Holunderblüte" (1863) de Wilhelm Raabe et "Ein Bekenntnis" (1887) de Theodor Storm allient psychologie, maladie et narration. Les deux textes racontent l’histoire de médecins qui à la fin de leur vie se questionnent sur leur propre responsabité dans un épisode du passé qui changea définitivement le cours de leur existence: la maladie et la mort de l’être qui leur était le plus cher (une jeune fille chez Raabe, l’épouse chez Storm). Par rapport aux études psychanalytiques très nombreuses dans la recherche sur Storm, cette étude souhaite montrer que la profondeur psychologique des textes doit être décrite par une analyse tenant compte du rôle anthropologique de la narration. Au niveau des narrateurs, la narration a ainsi une valeur curative pour ces deux médecins souffrant de sentiments de culpabilité et souhaitant retracer leur vie comme un sentier linéaire, cohérent et imbibé de sens. Les fonctions anthropologiques de la narration (production de sens, réduction de la contingence et de l’angoisse) auxquelles font appel ces individus sont toutefois relativisées par les textes eux-mêmes qui par leur forme et par le motif du labyrinthe évoquent l’aléatoire, la contingence et l’absence de sens. [less ▲]

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See detailDevelopment of an Environmental Information System for Odour using Citizen and Technology Innovative Sensors and Advanced Modelling
Uhrner, Ulrich; Grosso, gioavanna; Romain, Anne-Claude ULiege et al

in CEUR Workshop Proceedings (2014), 1322

The challenge of OMNISCIENTIS is to develop a community based odour monitoring and information system to mitigate odour annoyance and to foster citizens’ participation in environmental governance. The ... [more ▼]

The challenge of OMNISCIENTIS is to develop a community based odour monitoring and information system to mitigate odour annoyance and to foster citizens’ participation in environmental governance. The core is an information system collecting various data of odour emissions obtained by electronic noses and other sensors, meteorological conditions and observations by citizens acting as human sensors. A specific odour dispersion model is developed to use all this information and provide immediate feedback to all stakeholders. This work presents the architecture of the environmental information system, some first results from odour monitoring and model development and validation. [less ▲]

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See detailCharged lepton flavor violation beyond minimal supersymmetry
Vicente, Avelino ULiege

in Nuclear Physics B Proceedings Supplement (2014), 248-250

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See detailSleep loss changes executive brain responses in the wake maintenance zone
Jaspar, Mathieu ULiege; Meyer, Christelle ULiege; Muto, Vincenzo ULiege et al

in Journal of Sleep Research (2014), 23(1), 61

Objectives: Brain mechanisms underlying executive processes are regulated by circadian and sleep homeostatic processes. Furthermore, during sleep deprivation (SD), cognitive performance and neural ... [more ▼]

Objectives: Brain mechanisms underlying executive processes are regulated by circadian and sleep homeostatic processes. Furthermore, during sleep deprivation (SD), cognitive performance and neural responses are differentially modulated by a clock gene PERIOD3 polymorphism. Here, we investigated interindividual differences on executive brain responses under SD. Critically, we focused on the circadian evening wake maintenance zone (WMZ), a key time-point for sleep-wake regulation. Methods: Thirty healthy young volunteers, genotyped for the PER3 polymorphism (10 PER3 5/5; 20 PER3 4/4 homozygotes), underwent 42-h SD under constant routine conditions. They performed a 3-back working memory task in 13 successive fMRI sessions. To compare neural activity in the WMZ before and during SD, sessions were realigned according to individual dim light melatonin onset. Results: We tested for a group (PER3 5/5 > PER3 4/4) by session effect (WMZ before vs. during SD). From the fi rst evening WMZ (i.e. during a normal waking day) to the second (i.e. following 40 h of continuous waking), PER3 5/5 individuals relative to PER3 4/4 showed significantly larger increase in responses in the left mid-cingulate, bilateral precuneus and thalamus. Interestingly, these regions are involved in executive processes and arousal regulation (thalamus). Conclusions: These results show that the strong circadian wake-maintenance signal depends on sleep pressure, in a PER3-genotype dependent manner. Interestingly, pronounced genotype differences were observed in the thalamus, an area that compensates potential lower cortical activity under SD. [less ▲]

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See detailThe Extreme UV Imager of Solar Orbiter – From detailed design to Flight Model
Halain, Jean-Philippe ULiege; Rochus, Pierre ULiege; Renotte, Etienne ULiege et al

in Proceedings of SPIE (2014), 9144

The Extreme Ultraviolet Imager (EUI) on-board the Solar Orbiter mission will provide full-sun and high-resolution image sequences of the solar atmosphere at selected spectral emission lines in the extreme ... [more ▼]

The Extreme Ultraviolet Imager (EUI) on-board the Solar Orbiter mission will provide full-sun and high-resolution image sequences of the solar atmosphere at selected spectral emission lines in the extreme and vacuum ultraviolet. After the breadboarding and prototyping activities that focused on key technologies, the EUI project has completed the design phase and has started the final manufacturing of the instrument and its validation. The EUI instrument has successfully passed its Critical Design Review (CDR). The process validated the detailed design of the Optical Bench unit and of its sub-units (entrance baffles, doors, mirrors, camera, and filter wheel mechanisms), and of the Electronic Box unit. In the same timeframe, the Structural and Thermal Model (STM) test campaign of the two units have been achieved, and allowed to correlate the associated mathematical models. The lessons learned from STM and the detailed design served as input to release the manufacturing of the Qualification Model (QM) and of the Flight Model (FM). The QM will serve to qualify the instrument units and sub-units, in advance of the FM acceptance tests and final on-ground calibration. [less ▲]

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See detailImpact of ancient charcoal kilns on chemical properties of several forest soils after 2 centuries
Dufey, Joseph; Hardy, Brieuc; Cornelis, Jean-Thomas ULiege

in Geophysical Research Abstracts (2014)

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See detailEffect of different technological approaches on the optical properties of ZnO sol-gel thin films
Ivanova, T.; Harizanova, A.; Koutzarova, T. et al

in Journal of Physics: Conference Series (2014), 514

The work presents a sol-gel approach with two types of solvents for ZnO films deposition in view of varying the films' structural and optical properties. The ZnO films were characterized by X-Ray ... [more ▼]

The work presents a sol-gel approach with two types of solvents for ZnO films deposition in view of varying the films' structural and optical properties. The ZnO films were characterized by X-Ray diffraction (XRD) and found to have a polycrystalline wurtzite phase structure. The grain sizes and the lattice parameters were determined; it was established that the ZnO crystallites' size increases with the annealing temperatures from 25 nm to 36 nm. The ZnO films possess high transmittance in the visible spectral range. Further, the optical band gap values were estimated. The material's vibration properties were analyzed by Fourier Transform Infrared (FTIR) spectroscopy. The two technological sol-gel approaches for deposition of ZnO films, using two different solvents, proved to be successful in producing structures with different structural and optical properties. The thin films fabricated were very smooth and uniform and exhibited a high transparency in the visible spectral range. [less ▲]

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See detailLe speedrun : pratique compétitive, ludique ou créative ? Trajectoire d’un détournement de jeu vidéo institué en nouveau game
Barnabé, Fanny ULiege

in Culture Numérique (2014)

Ce travail vise à interroger la manière dont les jeux vidéo et les dynamiques de détournement qu’ils suscitent chez les joueurs redéfinissent la traditionnelle opposition entre consommation et création ... [more ▼]

Ce travail vise à interroger la manière dont les jeux vidéo et les dynamiques de détournement qu’ils suscitent chez les joueurs redéfinissent la traditionnelle opposition entre consommation et création. Dans ce but, nous étudierons un usage spécifique du médium vidéoludique qui s’est institué en véritable pratique créative sur internet : le speedrun (et son dérivé, le tool-assisted speedrun). L’analyse se déroulera en deux temps : une première partie envisagera les déplacements concrets qu’opère le speedrun dans les notions liées au pôle de la réception (qu’est-ce qu’être un joueur ou un spectateur au sein de ce domaine ?) ; la seconde étudiera la façon dont cette pratique participe à redéfinir le pôle de la production (que deviennent les notions d’auteur, d’œuvre et de création dans le cadre de cette activité ?). [less ▲]

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See detailStudy of sol-gel Cu-doped Al2O3 thin films: Structural and optical properties
Ivanova, T.; Harizanova, A.; Koutzarova, T. et al

in Journal of Physics: Conference Series (2014), 514

We present a study of of copper-doped Al2O3 films prepared by sol-gel deposition. The films were spin-coated on Si and quartz substrates and a high-temperature treatment was conducted in the range 500-800 ... [more ▼]

We present a study of of copper-doped Al2O3 films prepared by sol-gel deposition. The films were spin-coated on Si and quartz substrates and a high-temperature treatment was conducted in the range 500-800 °C in oxygen or nitrogen. The impact was followed of the annealing procedures on the AlxCu1-xO3 films's properties. XRD was used to determine the films' structure; it revealed a mixture of amorphous and crystalline phases. Optical characterization was performed by UV-VIS spectroscopy. The sol-gel films prepared are very transparent. The band gaps of the Al-Cu-O films were estimated from the optical data, with the values ranging from 3.4 to 4.8 eV depending on the Cu content, the annealing and the gas ambients. [less ▲]

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See detailQuadrupole splitting and isomer shifts in Te oxides investigated using nuclear forward scattering
Klobes, B.; Barrier, N.; Vertruyen, Bénédicte ULiege et al

in Hyperfine Interactions (2014), 226(1-3), 713-719

Nuclear forward scattering by 125Te is a viable alternative to conventional 125Te Mössbauer spectroscopy avoiding all source related issues. Using reference compounds with known hyperfine parameters and ... [more ▼]

Nuclear forward scattering by 125Te is a viable alternative to conventional 125Te Mössbauer spectroscopy avoiding all source related issues. Using reference compounds with known hyperfine parameters and Te oxides exhibiting stereochemically active lone pairs, we show that nuclear forward scattering by 125Te can be reliably used to extract quadrupole splitting energy and relative isomer shift. The rough correlation between Te-Ocoordination and quadrupole splitting energy as put forward by Takeda and Greenwood (J. Chem. Soc. Dalton, 2207, 1975), is corroborated by the presented results. © 2014 Springer Science+Business Media Dordrecht. [less ▲]

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See detailAltered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy
Tosi, Irène ULiege; Art, Tatiana ULiege; Cassart, Dominique ULiege et al

in Equine Veterinary Journal. Supplement (2014), 46(Suppl 46), 9

Introduction: Exertional myopathies are a common cause of exercise intolerance in the equine athlete, and Polysaccharide Storage Myopathy (PSSM) is a widely described muscular disease. It is characterized ... [more ▼]

Introduction: Exertional myopathies are a common cause of exercise intolerance in the equine athlete, and Polysaccharide Storage Myopathy (PSSM) is a widely described muscular disease. It is characterized by an accumulation of abnormal glycogen in myofibers due to a genetic defect in the skeletal muscle glycogen synthase (GYS1) enzyme. We hypothesized that energy production through oxidative phosphorylation (OXPHOS) in muscular mitochondria might be impaired in type-1 PSSM-affected horses. Methods: Eight horses with a history of exertional rhabdomyolysis were tested for the GYS1 mutation. Muscle biopsies were collected and used for histological analysis and high resolution respirometry (HRR). HRR values from 3 groups of horses (5 PSSM-positive horses, 3 horses with a history of myopathy but PSSM-negative and 16 healthy controls) were compared using a linear mixed model to take into account repeated (2–3 times) measurements made for each horse. Results: In 5/8 horses histology revealed an accumulation of abnormal glycogen in myofibers. These 5 horses also tested positive for the GYS1 mutation. A severe depression of maximal OXPHOS capacitywas observed by HRR in 7/8 horses with exertional rhabdomyolysis, with lower values in PSSM-positive cases (4/5). Conclusions: Our study shows a severely decreased OXPHOS capacity in PSSM-affected horses. PSSM is considered primarily a defect in glycogen synthesis but altered OXPHOS might play a central role in its pathogenesis. [less ▲]

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See detailThe metabolic syndrome is a risk factor for postoperative obstructive apnoea and hypoxaemia in morbidly obese patients: 5AP3-1
Devillers, H.; HANS, Grégory ULiege; Brichant, Jean-François ULiege et al

in European Journal of Anaesthesiology (2014), 31

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See detailAssociation entre la masse musculaire totale et la densité minérale osseuse de la hanche
Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege; Slomian, Justine ULiege et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 125-6

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See detailPrévalence de la sarcopénie : impact de l'utilisation de différentes valeurs seuils de diagnostic
Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege; Slomian, Justine ULiege et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 126

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See detailValidation des paramètres de marche par un système accélérométrique (Locométrix ®) à l’aide d’un système opto-électronique 3D (Coda Motion ®)
GILLAIN, Sophie ULiege; Schwartz, C; Dramé, M et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 186

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See detailEvaluation du nombre de résidents en maison de retraite médicalisée bénéficiant d'une supplémentation en vitamine D
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; Cavalier, Etienne ULiege et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 68

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See detailConcordance entre la masse musculaire mesurée par impédance bioélectrique et par absorptiométrie radiologique à double énergie
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; Dardenne, Nadia ULiege et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 182

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See detailThe science case for the Planet Formation Imager (PFI)
Kraus, S.; Monnier, J.; Harries, T. et al

in Proceedings of SPIE - The International Society for Optical Engineering (2014), 9146

Among the most fascinating and hotly-debated areas in contemporary astrophysics are the means by which planetary systems are assembled from the large rotating disks of gas and dust which attend a stellar ... [more ▼]

Among the most fascinating and hotly-debated areas in contemporary astrophysics are the means by which planetary systems are assembled from the large rotating disks of gas and dust which attend a stellar birth. Although important work has already been, and is still being done both in theory and observation, a full understanding of the physics of planet formation can only be achieved by opening observational windows able to directly witness the process in action. The key requirement is then to probe planet-forming systems at the natural spatial scales over which material is being assembled. By definition, this is the so-called Hill Sphere which delineates the region of influence of a gravitating body within its surrounding environment. The Planet Formation Imager project (PFI; http://www.planetformationimager.org) has crystallized around this challenging goal: to deliver resolved images of Hill-Sphere-sized structures within candidate planethosting disks in the nearest star-forming regions. In this contribution we outline the primary science case of PFI. For this purpose, we briefly review our knowledge about the planet-formation process and discuss recent observational results that have been obtained on the class of transition disks. Spectro-photometric and multi-wavelength interferometric studies of these systems revealed the presence of extended gaps and complex density inhomogeneities that might be triggered by orbiting planets. We present detailed 3-D radiation-hydrodynamic simulations of disks with single and multiple embedded planets, from which we compute synthetic images at near-infrared, mid-infrared, far-infrared, and sub-millimeter wavelengths, enabling a direct comparison of the signatures that are detectable with PFI and complementary facilities such as ALMA. From these simulations, we derive some preliminary specifications that will guide the array design and technology roadmap of the facility. © 2014 SPIE. [less ▲]

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See detailMathématiques convoquées par le registre graphique au sein du cours de physique
Renkens, Céline; Henry, Valérie ULiege

in Quaderni di Ricerca in didattica (2014), 24(1), 388

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See detailPlanet Formation Imager (PFI): Introduction and technical considerations
Monnier, J. D.; Kraus, S.; Buscher, D. et al

in Proceedings of SPIE - The International Society for Optical Engineering (2014), 9146

Complex non-linear and dynamic processes lie at the heart of the planet formation process. Through numerical simulation and basic observational constraints, the basics of planet formation are now coming ... [more ▼]

Complex non-linear and dynamic processes lie at the heart of the planet formation process. Through numerical simulation and basic observational constraints, the basics of planet formation are now coming into focus. High resolution imaging at a range of wavelengths will give us a glimpse into the past of our own solar system and enable a robust theoretical framework for predicting planetary system architectures around a range of stars surrounded by disks with a diversity of initial conditions. Only long-baseline interferometry can provide the needed angular resolution and wavelength coverage to reach these goals and from here we launch our planning efforts. The aim of the "Planet Formation Imager" (PFI) project is to develop the roadmap for the construction of a new near-/mid-infrared interferometric facility that will be optimized to unmask all the major stages of planet formation, from initial dust coagulation, gap formation, evolution of transition disks, mass accretion onto planetary embryos, and eventual disk dispersal. PFI will be able to detect the emission of the cooling, newlyformed planets themselves over the first 100 Myrs, opening up both spectral investigations and also providing a vibrant look into the early dynamical histories of planetary architectures. Here we introduce the Planet Formation Imager (PFI) Project (www.planetformationimager.org) and give initial thoughts on possible facility architectures and technical advances that will be needed to meet the challenging top-level science requirements. © 2014 SPIE. [less ▲]

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See detail“Product-oriented engineering” applied to the development of porous scaffolds for tissue engineering
de Bien, Charlotte ULiege; Ounally, T; Collard, Valérie ULiege et al

in World Congress in Industrial Process Tomography (2014)

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D ... [more ▼]

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D microstructure was characterized by X-ray microtomography and related to the operating conditions used. Two types of scaffold end-use properties were characterized in relation to their microstructure: the mechanical and the transport properties. Scaffold young's modulus was computed from data measured on tension-compression devices. To evaluate the permeability, Darcy’s experiments were carried out. The obtained results allowed highlighting the quantitative relationships existing between elaboration conditions, microstructure and end-use properties of the fabricated PLA scaffolds. © 2014 International Society for Industrial Process Tomography. [less ▲]

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See detailEstimating Relative Change in Ventricular Stroke Work from Aortic Pressure Alone: Proof of Concept Study
Kamoi, Shun; Pretty, Christopher; Chiew, Yeong Shiong et al

in Biomedizinische Technik. Biomedical Engineering (2014)

Continuous Ventricular Stroke Work (VSW) estimation requires accurate estimate of both stroke volume and aortic pressure. However, accurate beat-to-beat stroke volume measurement is highly invasive and ... [more ▼]

Continuous Ventricular Stroke Work (VSW) estimation requires accurate estimate of both stroke volume and aortic pressure. However, accurate beat-to-beat stroke volume measurement is highly invasive and thus typically unavailable in clinical practice. This study analyses the accuracy of a model-based method estimating relative change in VSW using only aortic pressure measurements. Using data from porcine experiment, the correlation coefficient was determined between the relative change of VSW from directly measured data and the model-based estimate of VSW. The result showed good agreement with, R=0.71. The model accurately captured the trend of VSW using only aortic pressure measurements and thus offers significant clinical value in early diagnosis and improving care for cardiovascular dysfunction. [less ▲]

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See detailExamining the right dorsal premotor mosaic: a connectivity-based parcellation approach
Genon, Sarah ULiege; Müller, Veronika I.; Cieslik, Edna et al

in Proceedings of the Annual Meeting of the Organization of Human Brain Mapping (2014)

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See detailImpact of circadian phase and prior wakefulness on cognition-related cerebral activity in humans
Reichert, Carolin; Maire, Micheline; Gabel, Virginie et al

in Journal of Sleep Research (2014), 23(Suppl.1), 29

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See detailAssessing the foraging behavior of Agriotes sordidus wireworms in dual-choice olfactometers
Barsics, Fanny ULiege; Fiers, Marie; Fauconnier, Marie-Laure ULiege et al

in Communications in Agricultural and Applied Biological Sciences (2014), 79(2), 151-156

The different steps of the foraging process of wireworms (Coleoptera: Elateridae) would be better understood if accurate and holistic information regarding the role of plant-produced chemicals ... [more ▼]

The different steps of the foraging process of wireworms (Coleoptera: Elateridae) would be better understood if accurate and holistic information regarding the role of plant-produced chemicals constituting their environment were available. Volatile organic compounds (VOC) play important roles in the interactions between plants and insects in many ecosystems, whether they take place aboveground or belowground. The roles of VOC are still relatively unknown for wireworms, and deserve attention. Here, we performed three experimentations with barley roots as baits. In the two first, we assessed the effect of chopped roots and fungus infected roots on the orientation of wireworms. In the third experiment, the larvae were confronted to both healthy and fungus infected roots. We discuss the results in terms of suitability of the olfactometers we designed for the investigation of olfaction in wireworms, and we provide suggestions to improve their use. [less ▲]

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See detailMeasurement of trace level Dechlorane flame retardants in food and feed by GC-MS/MS
Calaprice, Chiara ULiege; L'Homme, Benjamin; Brasseur, Catherine et al

in Organohalogen Compounds (2014), 76

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See detailMAGiC DRAGONS: A protocol for accurate glycaemic control in general wards
Thomas, Felicity Louise ULiege; Tomlinson, H.; Waston, A. et al

in IFAC Proceedings Volumes (IFAC-PapersOnline) (2014), 19

Accurate glycaemic control (AGC) has been shown to be beneficial to the outcomes of critically ill patients. These benefits may also extend to patients in less acute wards, particularly those with ... [more ▼]

Accurate glycaemic control (AGC) has been shown to be beneficial to the outcomes of critically ill patients. These benefits may also extend to patients in less acute wards, particularly those with existing diabetes. However, the clinical demands of an intensive care glycaemic control protocol are not appropriate for the general wards where the nurse-to-patient ratio is much lower and patients do not typically have an intravenous line available for insulin delivery. Thus, there is a need for a safe, effective glycemic control protocol tailored to the needs of general wards to enable appropriate care for diabetic patients and further testing of the benefits of glycaemic control for this cohort. This paper presents the development and testing of such a protocol for glycaemic control in the general wards. The DRAGONS protocol (Dynamic Regulation for Accurate Glycaemic-control Optimising iNsulin Subcutaneously) was designed to use subcutaneous insulin and only require blood glucose (BG) measurements every four hours, while maintaining BG concentrations within the range 4.4-8.0 mmol/L. Virtual trial simulation indicated an expected time in the target band of 73.0%, with < 2% risk of BG < 4.0 mmol/L. In the first patient recruited to the pilot trial, the DRAGONS protocol achieved 46% time in band and no severe hypoglycaemic episodes. This trial has also highlighted the need for careful selection of the insulin injection site to prevent excessively rapid transport to plasma. © IFAC. [less ▲]

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See detailIntegration by parts and representation of information functionals
Nourdin, Ivan; Peccati, Giovanni; Swan, Yvik ULiege

in IEEE International Symposium on Information Theory Proceedings (2014)

We introduce a new formalism for computing expectations of functionals of arbitrary random vectors, by using generalised integration by parts formulae. In doing so we extend recent representation formulae ... [more ▼]

We introduce a new formalism for computing expectations of functionals of arbitrary random vectors, by using generalised integration by parts formulae. In doing so we extend recent representation formulae for the score function introduced in \cite{nourdin2013entropy} and also provide a new proof of a central identity first discovered in \cite{guo2005mutual}. We derive a representation for the standardised Fisher information of sums of i.i.d. random vectors which {we} use to provide rates of convergence in information theoretic central limit theorems (both in Fisher information distance and in relative entropy) {and a Stein bound for Fisher information distance.} [less ▲]

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See detailValidated ready-to-use GC-MS/MS method for dioxin analysis in food and feed following the new EU Regulations
l'homme, Benjamin; Sandy, Chris; Scholl, Georges ULiege et al

in Organohalogen Compounds (2014), 76

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See detailThrombose veineuse rénale : un cas didactique
Tribolet, Sophie ULiege; DRESSE, Marie-Françoise ULiege; Lombet, Jacques et al

in Journal du pédiatre Belge (2014)

On retiendra que, devant toute hématurie macroscopique accompagnée d’une thrombocytopénie, d’une masse abdominale et/ou d’une anurie, voire d’une hypertension artérielle chez un nouveau-né, le diagnostic ... [more ▼]

On retiendra que, devant toute hématurie macroscopique accompagnée d’une thrombocytopénie, d’une masse abdominale et/ou d’une anurie, voire d’une hypertension artérielle chez un nouveau-né, le diagnostic de thrombose veineuse rénale doit être évoqué. L’échographie Doppler rénale est l’examen de choix pour le confirmer. En l’absence de consensus thérapeutique, outre la surveillance et la correction éventuelle des troubles hydroélectrolytiques, une héparinothérapie pourrait être initiée afin d’éviter l’extension thrombotique. La fibrinolyse est à réserver aux cas exceptionnels d’atteinte bilatérale. Cette pathologie reste malheureusement grevée d’une morbidité importante, avec parfois une atrophie, une insuffisance rénale et une hypertension artérielle. [less ▲]

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See detailImpact of earthquake-triggered landslides on catchment sediment yield
Vanmaercke, Matthias ULiege; Obreja, F.; Poesen, J. et al

in IAHS-AISH Proceedings and Reports (2014), 367

This study explores the role of seismic activity in explaining spatial and temporal variation in sediment export from the Siret basin in Romania. Based on long-term (>30 years) sediment export ... [more ▼]

This study explores the role of seismic activity in explaining spatial and temporal variation in sediment export from the Siret basin in Romania. Based on long-term (>30 years) sediment export measurements for 38 subcatchments, we found that spatial variation in sediment yield (SY) is strongly correlated to the degree of seismic activity and catchment lithology. Combined, these factors explain 80% of the variation in SY. To investigate the role of earthquake-triggered landslides in explaining these correlations, we studied the temporal variability in sediment concentrations before and after the 7.4 Mw earthquake of 1977 for ten subcatchments. Despite the fact that this earthquake triggered many landslides, only one subcatchment showed a clear (3-fold) increase in sediment concentration per unit discharge after the earthquake. This shows that, although prolonged seismic activity strongly controls average SY, individual earthquakes do not necessarily affect sediment export at short timescales. Copyright © 2014 IAHS Press. [less ▲]

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See detailEfficacy of mental imagery to improve autobiographical memory in multiple sclerosis patients: a double approach in neuropsychology and neuroimaging
Ernst, Alexandra ULiege; Blanc, Frédéric; Gounot, Daniel et al

in Multiple Sclerosis Journal (2014), 20

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See detailSimulation of a vertical ground heat exchanger as low temperature heat source for a closed adsorption seasonal storage of solar heat
Hennaut, Samuel ULiege; Thomas, Sébastien ULiege; Davin, Elisabeth ULiege et al

in Energy Procedia (2014), 48

Get It @ ULg(opens in a new window)|View at Publisher| Export | Download | More... Energy Procedia Volume 48, 2014, Pages 370-379 2nd International Conference on Solar Heating and Cooling for Buildings ... [more ▼]

Get It @ ULg(opens in a new window)|View at Publisher| Export | Download | More... Energy Procedia Volume 48, 2014, Pages 370-379 2nd International Conference on Solar Heating and Cooling for Buildings and Industry, SHC 2013; Freiburg; Germany; 23 September 2013 through 25 September 2013; Code 104547 Simulation of a vertical ground heat exchanger as low temperature heat source for a closed adsorption seasonal storage of solar heat (Conference Paper) Hennaut, S.a , Thomas, S.a, Davin, E.a, Skrylnyk, A.b, Frère, M.b, André, P.a a University of Liège, Building Energy Monitoring and Simulation, Avenue de Longwy 185, 6700 Arlon, Belgium b University of Mons, Energy Research Cente, Boulevard Dolez 31, 7000 Mons, Belgium View references (9) Abstract This paper deals with the simulation of a vertical geothermal heat exchanger as low temperature heat source for a closed adsorption seasonal heat storage. The seasonal storage should allow reaching a nearly 100 % solar fraction for space heating of a "low energy" building". The selected adsorbent and adsorbate are respectively bromide strontium and water. The studied system, including the building and the ground exchanger, is simulated using the dynamic simulation software TRNSYS. Results show that expected performances are reached with a borehole of 100 m. The evaporation temperatures computed are really close to 0°C which might cause some problems. But an advanced research would maybe impose a deeper borehole to avoid cooling the ground on the long term. [less ▲]

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See detailEvaluation of drug related problems in Belgium: focus on corticosteroids
Lelubre, Melanie; Koubaity, Majda; De Wulf, Isabel et al

in International Journal of Clinical Pharmacy [=IJCP] (2014), 36

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See detailIn vitro study toward the endocrine activity and the genotoxic potential of migration products from plastic baby bottles
Simon, Coraline ULiege; Onghena, M.; Covaci, A. et al

in Organohalogen Compounds (2014), 76

Bisphenol A (BPA) is documented in several studies to be a well-known source of food contamination. Recently, the European Union took a series of measures, including a ban for the import and sale of ... [more ▼]

Bisphenol A (BPA) is documented in several studies to be a well-known source of food contamination. Recently, the European Union took a series of measures, including a ban for the import and sale of polycarbonate (PC) baby bottles to reduce BPA exposure of infants. Plastic alternatives to PC, which have massively appeared on the Belgian market, include polypropylene (PP), silicone, polyamide (PA) and polyethersulfone (PES). In a recent opinion (No. 8697, 11.03.2010), the Belgian Superior Health Council issued its concern regarding the alternatives to PC currently used. Furthermore, they asked to investigate the possible risks associated with the use of these alternatives. In this study, a screening towards the endocrine activity of chemicals migrating from PC alternatives, identified by the group of Simoneau, was performed by using different reporter gene assays. Furthermore, the genotoxic potential of these compounds was also assessed with the Vitotox assay, an indicator test for DNA damage. The aim of the screening was to select the substances that may present a risk for human health and thus require further characterization. [less ▲]

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See detailSteroid-like activity of migration products from non polycarbonate plastic baby bottles.
Simon, Coraline ULiege; Onghena, Matthias; Covaci, Adrian et al

in Toxicology Letters (2014), 229

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See detailSelf-medication in persistent rhinitis: overuse of decongestants in half of the patients
Gevaert, Ph; Mehuys, E; Brusselle, G et al

in Allergy (2014), 69(Suppl. 99), 475-476

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See detailSelf-medication of headache: identification of subgroups of patients through cluster analysis
Mehuys, E; Paemeleire, K; Crombez, G et al

in Journal of Headache and Pain (2014), 15(Suppl. 1), 46

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See detailValidation of the Dutch version of the Sino-Nasal Outcome Test-22 (SNOT-22) Questionnaire
Cox, Caroline; Vanderveken, Olivier; Wouters, K et al

in B-ENT (2014)

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See detailUSING TOP PREDATORS AND DR-CALUX TO SCREEN COASTAL ENVIRONMENTS FROM THREE DIFFERENT BRAZILIAN REGIONS FOR DIOXINS AND RELATED COMPOUNDS
Dorneles; Lailson-Brito; Bisi et al

in Organohalogen Compounds (2014), 76

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See detailFibromatose desmoide : une masse cervicale peu banale
Tribolet, Sophie ULiege; Francotte, Nadine; Chantrain, Christophe et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2014)

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See detailYearly Follow-up of Methane Turbulent Exchange Over an Intensively Grazed Pasture in Belgium
Dumortier, Pierre ULiege; Aubinet, Marc ULiege; Beckers, Yves ULiege et al

in Communications in Agricultural and Applied Biological Sciences (2014), 79(1), 91-96

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See detailStrategies to combine novel traits across countries: example of heat stress
Hammami, Hedi ULiege; Vandenplas, Jérémie ULiege; Carabaño, Maria-Jesus et al

in Interbull Bulletin (2014), 48

Nowadays, novel traits are of great interest. However, phenotypes are siloed and mainly not shared. Heat stress is becoming problematic affecting animals’ performances and their well-being. Heat stress ... [more ▼]

Nowadays, novel traits are of great interest. However, phenotypes are siloed and mainly not shared. Heat stress is becoming problematic affecting animals’ performances and their well-being. Heat stress tolerance as a novel trait is only addressed by isolated within-country research studies. Integration and combination of local and foreign information sources is needed for better accuracy genetic evaluations. Therefore, this study was aimed to test the potential combination of sources of external information towards the evaluation of heat stress tolerance of dairy cattle. Long-term cow performances linked to environmental descriptors (weather parameters as proxy to climate change) collected over 10 years under the temperate conditions of the Walloon Region of Belgium and the hotter and warm Mediterranean conditions of Andalusia and Castile-La-Mancha Spanish regions were available. A total of 1,604,775 milk, fat, and protein test-day (TD) records linked to average daily temperature humidity (THI) values for 3-day lag before each TD were considered. Under a first strategy considering free-access to raw-data (phenotype and pedigree), a joint evaluation was firstly run using reaction norm models where production traits were considered as function of THI. A Belgian and a Spanish evaluation were also run using the same model. An alternative strategy considering only access to external information (i.e. regression coefficients for additive genetic effects (â and their associated REL)) was tested. In this case, foreign â and their REL resulting from the Spanish evaluation were first converted to the Belgian trait and thereafter integrated in the Belgian <br /><br />evaluation using a Bayesian approach. Rank correlations between regression coefficients, â (of the 1,104 bulls having daughters only in Spain) estimated by Belgian evaluation and â estimated by the joint evaluation were moderate (<=0.70). Corresponding rank correlations between â estimated by joint and Bayesian evaluations were significantly higher (ranging from 0.967 to 0.998), indicating that the Bayesian evaluation integrating external information was in good concordance with the joint evaluation. Results from this study indicated that the integration of external information via the Bayesian approach has a good potential to improve the genetic evaluation of sparse and siloed novel traits. [less ▲]

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See detailArbitrary Lagrangian Eulerian simulations of stationary and non-stationary metal forming processes
Boman, Romain ULiege; Ponthot, Jean-Philippe ULiege

in AIP Conference Proceedings (2013, December 16), 1567

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See detailEvolution of the theoretical power spectrum of solar-like oscillations along the ascending phase on the red giant branch.
Grosjean, Mathieu ULiege; Dupret, Marc-Antoine ULiege; Belkacem, Kevin et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. An important question comes from the observation of mixed ... [more ▼]

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. An important question comes from the observation of mixed modes : When during the star’s ascension on the RGB are mixed-modes more likely to be detectable ? We follow the evolution of a star on the RGB and investigate the effect of its ascension on theoretical power spectrum. Equilibrium models (computed with the code ATON) represent four different stages of a star on the RGB. The mass of the star (1.5M") is in the typical mass range of stars observed by CoRoT and Kepler. We used a non-radial non-adiabatic code to compute the theoretical solar-like oscillations of these models. An important output of these calculations is the theoretical lifetimes of the modes. Then we computed the oscillation amplitudes through a stochastic excitation model. These computations allow us to draw theoretical power spectrum and discuss the possibility to observe mixed-modes at different evolutionary stages on the RGB. We found that structure modifications in a star ascending the RGB have an important impact on theoretical power spectrum of solar-like oscillations. Efficiencies of trapping and lifetimes of mixed modes are indeed strongly affected by this evolution. [less ▲]

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See detailIS ULTRA-SHORT COLD ISCHEMIA THE KEY TO ISCHEMIC CHOLANGIOPATHY AVOIDANCE IN DCD- LT?
DETRY, Olivier ULiege; DE ROOVER, Arnaud ULiege; Cheham, Samir et al

in Transplant International (2013, December), 26(S2), 53-98

Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic ... [more ▼]

Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic cholangiopathy leading to graft loss. The authors retrospectively reviewed a single centre experience with DCD-LT in a 9-year period. Patients and Methods: 70 DCD-LT were performed from 2003 to November 2012. All DCD procedures were performed in operative rooms. Median donor age was 59 years. Most grafts were flushed with HTK solution. Allocation was centre-based. Median total DCD warm ischemia was 19.5 min. Mean follow-up was 36 months. No patient was lost to follow-up. Results: Median MELD score at LT was 15. Median cold ischemia was 235 min. Median peak AST was 1,162 U/L. Median peak bilirubin was 31.2 mg/dL. Patient and graft survivals were 92.8% and 91.3% at one year and 79% and 77.7% at 3 years, respectively. One graft was lost due to hepatic artery thrombosis. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Causes of death were malignancies in 8 cases. Discussion: In this series, DCD LT appears to provide results equal to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. [less ▲]

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See detailDONATION AFTER CIRCULATORY DEATH LIVER TRANSPLANTATION: IS DONOR AGE AN ISSUE?
DETRY, Olivier ULiege; Ledinh, Heu; HONORE, Pierre ULiege et al

in Transplant International (2013, December), 26(s2), 112-228

Background: Donation after circulatory death (DCD) donors > 55 years are usually not considered suitable for liver transplantation (LT). At our institute, age is not an absolute exclusion criterion to ... [more ▼]

Background: Donation after circulatory death (DCD) donors > 55 years are usually not considered suitable for liver transplantation (LT). At our institute, age is not an absolute exclusion criterion to refuse DCD liver grafts. We retrospectively compared the transplant outcome of patients receiving older DCD liver grafts to the younger ones. Methods: 70 DCD liver transplants have been performed from 2003 to 2012, which includes 32 liver grafts from younger donors <55y (group A), 20 between 56 and 69 years (group B), and 18 from older donors ≥70 years (group C). The three groups were compared in terms of donor and recipient demographics, procurement and transplantation conditions, peak laboratory values during the first post-transplant week and results at one and three years. Results are expressed as median IQR. Results: No difference other than age in donor and recipient characteristics as well as procurement conditions was noted between both groups. Median donor age of the group A was 44 (38-45) years, in group B 62 (60-64) years and 73 (71-75) in group C. Median primary warm ischemia time (WIT) were 20 (17-22), 21 (19-25) and 19 (16-23) min, respectively (NS). Median cold ischemia time (CIT) was 236 (229-294), 245 (227-290) and 210 (195-277) min, respectively (NS). Peak AST (UI/ml) was 1162 (1072-3971), 1416 (1006-2752), and 1067 (902-4037), respectively (NS). There was no primary nonfunction and one patient needed retransplantation for artery thrombosis. Biliary complications occurred similarly in both groups, without graft loss secondary to ischemic cholangiopathy. Graft and patient survivals were not different at one and three years. Conclusion: This study shows comparable results between DCD liver transplants from younger and older donors. Therefore donor age >55 years should not be a contraindication to DCD liver transplantation if other donor risk factors (such as WIT, CIT) are minimized. [less ▲]

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See detailForward Physics of Hadronic Colliders
Ivanov, Igor ULiege

in Physics of Particles and Nuclei Letters (2013, December), 10(7), 739750

These lectures were given at the Baikal Summer School on Physics of Elementary Particles and Astrophysics in July 2012. They can be viewed as a concise introduction to hadronic diffraction, to the physics ... [more ▼]

These lectures were given at the Baikal Summer School on Physics of Elementary Particles and Astrophysics in July 2012. They can be viewed as a concise introduction to hadronic diffraction, to the physics of the Pomeron and related topics. [less ▲]

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See detailThe instability strip of ZZ Ceti white dwarfs and its extension to the extremely low mass pulsators
Van Grootel, Valérie ULiege; Fontaine, Gilles; Brassard, Pierre et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection ... [more ▼]

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection in these stars. We report here a detailed stability survey over the whole ZZ Ceti regime, including the very low masses where three pulsators have recently been found. We computed to this aim 29 evolutionary sequences of DA models with various masses and chemical layering. These models are characterized by the so-called ML2/α=1.0 convective efficiency and take into account the important feedback effect of convection on the atmospheric structure. We pulsated these models with the Liege nonadiabatic pulsation code MAD, which is the only one to conveniently incorporate a full time-dependent convection treatment and, thus, provides the best available description of the blue edge of the instability strip. On the other hand, given the failure of all nonadiabatic codes to account properly for the red edge of the strip, including MAD, we tested the idea that the red edge is due to energy leakage through the atmosphere. Using this approach, we found that our theoretical ZZ Ceti instability strip accounts remarkably well for the boundaries of the empirical strip. [less ▲]

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See detailLes orthophonistes utilisent-ils les données issues de la recherche scientifique ? Analyse des pratiques afin d’ajuster la formation universitaire en Belgique
Durieux, Nancy ULiege; Pasleau, Françoise ULiege; Vandenput, Sandrina ULiege et al

in Glossa (2013, December), 113

Une des missions fondamentales d’une formation universitaire est de permettre aux futurs professionnels d’identifier et de traiter efficacement les informations nécessaires aux prises de décisions parmi ... [more ▼]

Une des missions fondamentales d’une formation universitaire est de permettre aux futurs professionnels d’identifier et de traiter efficacement les informations nécessaires aux prises de décisions parmi un nombre toujours croissant de documents disponibles. Pour atteindre cet objectif, le recours à l’Evidence-Based Practice (EBP) s’avère une approche méthodologique permettant d’acquérir les savoirs et savoir-faire requis pour, notamment, la recherche d’informations probantes. L’EBP doit donc logiquement faire partie de la formation initiale des futurs orthophonistes en restant en adéquation avec les besoins et pratiques des professionnels. À cette fin, il est important d’identifier les questions que se posent les cliniciens dans leur pratique quotidienne, la manière dont ils trouvent des réponses et s’ils ont recours ou non aux données issues de la recherche scientifique. Une enquête a été lancée en mai 2012 auprès d’orthophonistes travaillant en Communauté française de Belgique. La présente communication exposera les principaux résultats, recueillis auprès de 410 orthophonistes, qui conduiront à des pistes d’action pour l’enseignement universitaire et la formation continue. [less ▲]

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See detailWhite Dwarf Stars: A Brief Overview
Fontaine, Gilles; Brassard, Pierre; Charpinet, Stephane et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of ... [more ▼]

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of stellar evolution for the vast majority of stars and, as such, bear the signatures of past events (such as mass-loss, mixing phases, loss and redistribution of angular momentum, and thermonuclear burning) that are of essential importance in the evolution of stars in general. In addition, white dwarf stars represent ideal testbeds for our understanding of matter under extreme conditions, and work on their constitutive physics (neutrino production rates, conductive and radiative opacities, interior liquid and solid equations of state, partially ionized and partially degenerate envelope equations of state, diffusion coefficients, line broadening mechanisms) is still being actively pursued. Given a set of constitutive physics, cooling white dwarfs can be used advantageously as cosmochronometers. Moreover, the field has been blessed by the existence of four distinct families of pulsating white dwarfs, each mapping a different evolutionary phase, and this allows the application of the asteroseismological method to probe and test their internal structure and evolutionary state. [less ▲]

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See detailg-Mode Oscillations in Hot B Subdwarf Stars
Charpinet, Stéphane; Van Grootel, Valérie ULiege; Fontaine, Gilles et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact ... [more ▼]

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact helium core burning stars can develop low amplitude oscillations with periods in the range ∼ 1 − 4 hours that correspond to low degree, mid to high order g-modes. These modes have the property to penetrate deep inside the star, down to the boundary of the central convective core. They are consequently particularly interesting as asteroseismic probes. Here we briefly review how the g-modes behave in sdB stars, focusing in particular on the seismic signatures coming from the core itself. We also briefly summarize the first seismic results obtained from space data in pioneering efforts to exploit the potential of long period sdB pulsators as deep probes of the core structure. [less ▲]

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See detailDONATION AFTER CIRCULATORY DEATH INCREASES THE CADAVERIC DONOR POOL
Le Dinh, H.; DE ROOVER, Arnaud ULiege; SQUIFFLET, Jean-Paul ULiege et al

in Transplant International (2013, December), 26(S2), 54-101

Background: There is a controversy on the possibility to increase the organ donor pool by donation-after-circulatory-death (DCD) and the possible decrease in donation-after-brain-death (DBD) by DCD ... [more ▼]

Background: There is a controversy on the possibility to increase the organ donor pool by donation-after-circulatory-death (DCD) and the possible decrease in donation-after-brain-death (DBD) by DCD programs. Our aim is to report the DCD experience at the University Hospital of Liege, Belgium, from 2002 through 2012, in a donor region of about 1 million inhabitants. Methods: The prospective organ donor and recipient databases were retrospectively reviewed. Results: 94 and 331 procurements were performed from controlled DCD and DBD donors in the time period, respectively. DCD donors contributed to 22.1% of the deceased donor (DD) organ procurement activity from Jan 2002 to Dec 2012, and up to one-third annually since 2009. DCD liver and kidneys contributed 23.7% and 24.2% of the DD liver and kidney transplantation activity, respectively. There was no decrease of the DBD procurement in the study period. In 2012, overall 54 DD were procured in the Liege region, reaching a high procurement activity.Conclusions: Controlled DCD donors are a valuable source of transplantable liver and kidney grafts, and in our experience do not adversely affect DBD organ procurement activity. [less ▲]

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See detailA spectral operator-theoretic framework for global stability
Mauroy, Alexandre ULiege; Mezic, Igor

in Proceedings of the IEEE Conference on Decision and Control (2013, December)

The global description of a nonlinear system through the linear Koopman operator leads to an efficient approach to global stability analysis. In the context of stability analysis, not much attention has ... [more ▼]

The global description of a nonlinear system through the linear Koopman operator leads to an efficient approach to global stability analysis. In the context of stability analysis, not much attention has been paid to the use of spectral properties of the operator. This paper provides new results on the relationship between the global stability properties of the system and the spectral properties of the Koopman operator. In particular, the results show that specific eigenfunctions capture the system stability and can be used to recover known notions of classical stability theory (e.g. Lyapunov functions, contracting metrics). Finally, a numerical method is proposed for the global stability analysis of a fixed point and is illustrated with several examples. [less ▲]

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See detailSafety analysis of BOLERO-3 : a phase III trial of daily Everolimus vs placebo, both with weekly Trastuzumab and Vinorelbine in Trastuzumab-resistant, advanced breast cancer
JERUSALEM, Guy ULiege; Masuda, Norikazu; Andre, Fabrice et al

in Cancer Research (2013, December), 73(24), 3-15-03

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See detailThe SNAP trial : schedules of nab-Paclitaxel in metastatic breast cancer. International breast cancer study group (ICGSG 42-12) and breast international group (BIG 2-12)
Gennari, Alessandra; JERUSALEM, Guy ULiege; Maibach, Rudolf

in Cancer Research (2013, December), 73(24), 3-1-02

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See detailBOLERO-3 : Quality-of-life maintained in patients with HER-2 positive metastatic breast cancer treated with Everolimus plus Trastuzumab plus Vinorelbine
Isaacs, Claudine; Ozguroglu, Mustafa; JERUSALEM, Guy ULiege et al

in Cancer Research (2013, December), 73(24), 4-12-18

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See detailBOLERO-3 : Everolimus plus Trastuzumab and Vinorelbine in asian patients with HER2-positive metastatic breast cancer
Toi, Masakazu; Masuda, Norikazu; ANDRE, Fabrice et al

in Cancer Research (2013, December), 73(24), 4-12-19

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See detailAdherence to the ICU pain, agitation and delirium care bundle: audit of practices in a teaching hospital
Achen, C; Van Hees, Thierry ULiege; DAMAS, Pierre ULiege et al

in International Journal of Clinical Pharmacy [=IJCP] (2013, December), 35(6), 1288-1289

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See detailCombination Of Regulatory T Cells and Rapamycin As Treatment For Experimental Chronic Graft-Versus-Host Disease
Belle, Ludovic ULiege; Ehx, Grégory ULiege; SOMJA, Joan ULiege et al

in Blood (2013, December), 122(21), 4474

Background Chronic graft-versus-host disease (cGvHD) is one of the main complications of allogeneic hematopoietic cell transplantation (allo-HCT). Donor CD4+ conventional T cells (Tconv) as well as ... [more ▼]

Background Chronic graft-versus-host disease (cGvHD) is one of the main complications of allogeneic hematopoietic cell transplantation (allo-HCT). Donor CD4+ conventional T cells (Tconv) as well as regulatory T cells (Treg) are the key-players in its pathogenesis. Rapamycin (sirolimus, rapa) is a mTor inhibitor that can suppress activation and proliferation of Tconv without inhibiting Treg. Aims To assess the impact of a combined treatment with Tregand rapa on experimental cGvHD. Methods Lethally irradiated BALB/c mice were injected with 10x106 bone marrow cells and 70x106 splenocytes from B10.D2 donor mice. Mice were divided in four groups on day -1 and treatments were started on day 20 with either PBS, rapa 1 mg/kg/Day, Treg 1.106 cells (D+20), or rapa 1 mg/kg/Day + Treg 1.106 cells (D+20). Treg (CD4+ CD25+ cells) were purified from spleen cells from donor B10.D2 mice using the CD4+ CD25+ regulatory T cell isolation kit (Miltenyi Biotec, GmbH, Germany). Treg purity (defined as CD4+ FoxP3+ cells) was ≥ 70% of total cells and > 92% of CD4+T cells. The severity of sclerodermatous cGvHD was assessed with the following clinical scoring system. Briefly, animals were individually scored every 3 days for five parameters: weight loss (1, 10-20%; 2, > 20%), posture (1, kyphosis only at rest; 2, severe kyphosis when the animal moved), activity (1, moderate activity impairment; 2, no move unless stimulated), skin (1, erythema or scaling tail; 2, open lesion on the body surface) and hair loss (1, > 1 cm2; 2, > 2 cm2). Mice which reached a score of 8 were estimated to have terminal GvHD and were sacrificed. Terminal GvHD-free survivals between the 4 groups were compared using the Log-rank test. Results The effects of the treatments were evaluated 7 days after starting the treatments (D+27 post-transplantation). Numbers of total and central memory and effector memory CD4+ T cells/µL were significantly (p<0.05) decreased in rapa-, Treg-, and Treg + rapa- treated mice compared to PBS mice, while numbers of naïve CD4+ T cells/µL were significantly (p<0.05) decreased in Treg-, and Treg + rapa- treated mice. Further, proliferation of CD4+ T cells (assessed by Ki67 expression) was significantly decreased in rapa- (p<0.05) and Treg + rapa- treated mice (p<0.05). In addition, counts and proliferation of CD8+ T cells/µL were significantly (p<0.05) lower in rapa- and Treg+ rapa- treated mice compared to PBS mice. Importantly, terminal-GvHD-free survival was significantly shorter in PBS mice than in Treg (P=0.03), rapa (P=0.04), and Treg+ rapa mice (P=0.02). Conclusion Our results showed that Treg and rapa administration improved cGvHD in this model of cGvHD. [less ▲]

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See detailStimuli-responsive magnetic nanohybrids for triggered drug release and potential tumor treatment via hyperthermia
Liu, Ji ULiege; Detrembleur, Christophe ULiege; Mornet, Stéphane et al

in Journal of Controlled Release (2013, November 28), 172(1), 39

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See detailLarge Nc baryons and Regge trajectories
Matagne, Nicolas; Stancu, Floarea ULiege

in Bled Workshops in Physics (2013, November), 14(1), 37-42

The mixed symmetric positive and negative parity baryons are described in a similar way in the $1/N_c$ expansion method of QCD by using a procedure where the permutation symmetry is incorporated exactly ... [more ▼]

The mixed symmetric positive and negative parity baryons are described in a similar way in the $1/N_c$ expansion method of QCD by using a procedure where the permutation symmetry is incorporated exactly. This allows to express the mass formula in terms of a small number of linearly independent operators. We show that the leading term follows a different Regge trajectory from that found for symmetric states, when plotted as a function of the band number $N$. [less ▲]

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See detailPrevalence of cardiovascular risk factors in Wallonia (Belgium): results from the NESCaV study
Streel, Sylvie ULiege; Donneau, Anne-Françoise ULiege; Hoge, Axelle ULiege et al

in European Journal of Public Health (2013, November)

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See detailVitamin D coverage among adults in Wallonia (Belgium): findings from the NESCaV study
Hoge, Axelle ULiege; Donneau, Anne-Françoise ULiege; Streel, Sylvie ULiege et al

in European Journal of Public Health (2013, November), 23

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See detailSurvival improvement of secondary acute myeloid leukemia over time: experience from 962 patients included in 13 EORTC-Gimema-HOVON leukemia group trials
RAMADAN, Safaa M.; SUCIU, Stefan; STEVENS-KROEF, Marian J.P.L. et al

in Blood (2013, November), 122(21), 829

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See detailL’admissibilité de la preuve en droit civil et en droit pénal
Kefer, Fabienne ULiege

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2013, November), (2), 195-229

L’admissibilité d’une preuve, à savoir la vocation à être prise en considération comme élément de preuve, s’apprécie de manière différente selon qu’il s’agit d’un litige en matière pénale ou en matière ... [more ▼]

L’admissibilité d’une preuve, à savoir la vocation à être prise en considération comme élément de preuve, s’apprécie de manière différente selon qu’il s’agit d’un litige en matière pénale ou en matière civile au sens large. On distingue le système de la preuve libre (matière pénale) et celui de la preuve réglementée (matière civile). L’admissibilité est une question de fond. La question de l’admissibilité des preuves est, depuis plusieurs années, dominée par la jurisprudence de la Cour de cassation initiée par le célèbre arrêt Antigone du 14 octobre 2003, et selon laquelle les preuves irrégulièrement obtenues sont désormais admissibles, sauf si certains vices sont constatés. La circonstance qu’une preuve ou un élément de preuve a été obtenu illicitement n’entraîne pas l’exclusion de la preuve, même si cette irrégularité consiste dans une violation de droits fondamentaux garantis par les Conventions internationales ou la Constitution. Si le vice dans l’obtention de la preuve produite aux débats n’est pas sanctionné de nullité par la loi, c’est au juge qu’il appartient d’apprécier les conséquences de l’irrégularité sur la recevabilité de ce moyen de preuve : celui-ci ne sera pas pris en considération par le juge pour forger sa conviction si l'irrégularité commise a entaché la fiabilité de la preuve ou si elle compromet le droit à un procès équitable. L’arrêt de la Cour de cassation du 10 mars 2008 a, selon la grande majorité des commentateurs, étendu la jurisprudence Antigone à la matière civile, réalisant ainsi une unification de la jurisprudence afférente à ce question. Que le procès soit civil ou pénal, le droit au procès équitable et le principe de proportionnalité se sont substitués au principe de la légalité de la preuve. La tâche du juge s’en trouve complexifiée mais en contrepartie, il dispose de plus de moyens de réconcilier la vérité vraie et la vérité déclarée. Cette jurisprudence a été adoptée sous l’influence des droits étrangers. Le droit comparé révèle que d’autres systèmes juridiques considèrent que la justice serait parfois bien plus discréditée par un refus de prendre en considération des éléments de preuve recueillis de manière illégale que par leur admission et confient au juge le pouvoir de veiller à préserver cette image de la justice en sauvegardant l’équité du procès. [less ▲]

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See detailLocal perceptions and attitudes towards synanthrope long-tailed macaques (Macaca fascicularis) living in Padangtegal Monkey forest, Bali (Indonesia)
Brotcorne, Fany ULiege; Paquay, Leila; Wandia, I.Nengah et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, October 03), 85(1), 48

The sympatric relationship between humans and other primates in interface zones is a contemporary widespread phenomenon. The expanding landscapes anthropization leads to an intensification of human-other ... [more ▼]

The sympatric relationship between humans and other primates in interface zones is a contemporary widespread phenomenon. The expanding landscapes anthropization leads to an intensification of human-other primate interactions ranging from conflict to co-operation scenarios. Our study investigated the commensal relationships between long-tailed macaques and humans at the tourist Padangtegal Monkey Forest. We present here results related to human-macaque interactions and local people’s perceptions and attitudes towards the latter. We used ethological methods to quantify the nature of the interactions and we conducted a questionnaire survey to identify the macaques’ status in local public opinion. 99 respondents (62 males and 37 females) were selected in a radius of 2km around the Monkey Forest. Perceptions and attitudes were explicitly measured on self-reports and were attributed to a 4 point score. Macaques interacted with humans for 1.1% of their activity budget and these interactions were mostly aggressive (0.6%), food-related (0.4%) or neutral (0.1%). 80% of the aggressive interactions were initiated by humans but the majority aimed at protecting crops and properties from macaques’ incursions. Overall, most of the respondents had positive perceptions and attitudes towards macaques, except neighbouring landowner farmers who suffered from crop damage. Despite nuisances caused by macaques, the majority of the interviewees reported to derive compensatory economic and cultural benefits from their relationships with macaques. The religious and economic contexts might explain the high tolerance level towards macaques that represents a source of hope for a sustainable coexistence, although some management strategies minimizing crop damage still need to be reinforced. [less ▲]

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See detailStudy of the Forbidden Oxygen Lines in Comets at Different Heliocentric and Nucleocentric Distances
Decock, Alice ULiege; Rousselot, P.; Jehin, Emmanuel ULiege et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

Oxygen is an important element in the chemistry of the solar system objects given its abundance and its presence in many molecules including H2O 80% of cometary ices). The analysis of oxygen atoms in ... [more ▼]

Oxygen is an important element in the chemistry of the solar system objects given its abundance and its presence in many molecules including H2O 80% of cometary ices). The analysis of oxygen atoms in comets can provide information not only on the comets themselves but also on the solar system. These atoms have been analyzed using the 3 forbidden oxygen lines [OI] observed in emission in the optical region at 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the red lines) (Swings, 1962). Our analysis is based on a sample of 12 comets of various origins. The observing material is made of 53 high signal-to-noise spectra obtained with the high-resolution UVES spectrograph at the ESO VLT from 2002 to 2012 (Manfroid et al, 2009). After noticing that the green line is blended with one C2 line, we built synthetic spectra of C2 for each observing circumstances and we subtracted its contribution to the cometary spectra in order to ensure the decontamination of the 5577 Å line. Then, we measured the intensity of the 3 [OI] lines at different heliocentric distances. By comparing the green to red lines ratio (G/R) with the Bhardwaj & Raghuram (2012) effective excitation rates, we found that H2O is the main parent molecule when the comet is observed at 1 au. When the comet is located beyond 2.5 au from the Sun, CO2 also contributes to the production of oxygen. Studying forbidden oxygen lines could be a new way to estimate the abundances of CO2 in comets, a very difficult task from the ground (Decock et al. 2013). In order to estimate the effect of the quenching on our results, we analyzed the evolution of the G/R ratio at different nucleocentric distances. For nearby comets, we divided the extended 2D spectrum into several zones in order to analyze the oxygen lines as close as possible to the nucleus (down to ~10 km for the closest comets). Their analysis will allow us to study the link of the oxygen lines with the nucleocentric distance. We found a clear variation of the G/R ratio close to the comet nucleus that is in agreement with a contribution from CO2 as predicted by Raghuram & Bhardwaj (2013). [less ▲]

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See detailHyper-volatiles in Comet C/2010 G2 (Hill)
Kawakita, Hideyo; Dello Russo, N.; Vervack, R. J. J. et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The ... [more ▼]

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The comet had been in outburst. Over the two nights of our observations, prominent emission lines of CH4 and C2H6 along with weaker emission lines of H2O, HCN, CH3OH and CO were detected. The gas production rate of CO was comparable to that of H2O. The mixing ratios of CO, HCN, CH4, C2H6, and CH3OH with respect to H2O are higher than those for normal comets by a factor of five or more. Hyper-volatile species such as CO and CH4 were enriched in the coma of comet Hill suggesting that the sublimation of these hyper-volatiles could sustain the outburst of the comet. Based on a comparison with optical observations, some fraction of water in the inner coma existed as icy grains. Those icy ice grains were likely ejected from nucleus by the sublimation of hyper-volatiles. [less ▲]

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See detailA Search For 15NH2 Emission Lines In Comets
Rousselot, Philippe; Pirali, O.; Jehin, Emmanuel ULiege et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

The determination of nitrogen isotopic ratios in solar system objects is important for a good understanding of their origin. The measurements of [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio done so far in ... [more ▼]

The determination of nitrogen isotopic ratios in solar system objects is important for a good understanding of their origin. The measurements of [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio done so far in various solar system objects and molecules have revealed a great diversity (from 50 to 441), all of them, except Jupiter, being enriched in [SUB]15[/SUB]N compared to the protosolar nebula. Different explanations have been proposed to explain this enrichement. One of them suggests that these differences reflect the different interstellar N reservoirs from which N-bearing molecules are originating (Hily-Blant et al., 2013). These authors, from observations of H[SUB]13[/SUB]CN and HC[SUB]15[/SUB]N in two prestellar cores, suggest that the molecules carrying the nitrile- (-CN) functional group would be more enriched in [SUB]15[/SUB]N than the molecules carrying the amine (-NH) functional group. Comets are interesting targets to test this theory because they contain both HCN and NH[SUP]3[/SUP] molecules. So far the [SUB]14[/SUB]N/[SUB]15[/SUB]N ratio has only been measured in CN (Arpigny et al., 2003; Manfroid et al., 2009) and HCN (Bockelée-Morvan et al., 2005, 2008) in comets, leading for both species to [SUB]14[/SUB]N/[SUB]15[/SUB]N ≈ 150. Our work aimed at measuring the [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio in NH[SUP]2[/SUP], which comes from NH[SUP]3[/SUP]. We have determined accurately the wavelengths of [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines with the AILES beamline spectrometer at synchrotron SOLEIL by Fourier transform spectroscopy. The analysis of this spectrum has permitted to extract the [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines wavelengths and to search for [SUB]15[/SUB]NH[SUP]2[/SUP] cometary emission lines. Thanks to a collection of spectra of 12 different comets obtained from 2002 to 2011 with the UVES spectrometer at the VLT ESO 8-m telescope (Manfroid et al., 2009), it has been possible to search for [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines with a high sensitivity. We will present the results obtained from these data. Arpigny et al., Science, 301, 1522-1525, 2003 Bockelée-Morvan et al., in Comets II, ed. M. C. Festou, H. U. Keller, & H. A. Weaver (Tucson: Univ. Arizona Press), 391-423, 2005 Bockelée-Morvan et al., ApJ, 679, L49-L52, 2008 Hily-Blant et al., Icarus 223, 582-590, 2013 Manfroid et al., A&A, 503, 613-624, 2009 [less ▲]

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See detailThe May 4, 2013 Stellar Occultation by Pluto and Implications for Pluto's Atmosphere
Olkin, Catherine B.; Young, L. A.; Borncamp, D. et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

On May 4 2013, Pluto passed in front of a 14 star and the shadow was well observed from multiple occultation groups. This paper presents results from the three light curves observed at Las Cumbres ... [more ▼]

On May 4 2013, Pluto passed in front of a 14 star and the shadow was well observed from multiple occultation groups. This paper presents results from the three light curves observed at Las Cumbres Observatory Global Telescope Network (LCOGT) from their Cerro Tololo site. The three LCOGT telescopes have 1.0 m apertures and used identical frame-transfer cameras. The cameras currently have a 2 second readout time therefore autonomous observations were scheduled with different exposure times to give good time resolution of the event. We will present results of this occultation and compare occultation results from 1988 to 2013 with volatile transport models. [less ▲]

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See detailDNA fingerprinting using Diversilab system for genotyping characterization of Microsporum audouinii and Trichophyton violaceum
SACHELI, Rosalie ULiege; DIMO, Lauryl; GRAIDE, Hélène ULiege et al

in Mycoses (2013, October 01), 56(Supplement S3), 99

Objectives: To investigate the epidemiological determinants responsible for the high number of anthropophilic dermatophytes received by the National Reference Center for Mycosis of Liege (NRCL) during the ... [more ▼]

Objectives: To investigate the epidemiological determinants responsible for the high number of anthropophilic dermatophytes received by the National Reference Center for Mycosis of Liege (NRCL) during the year 2012. To perform a genotypic characterization by the Diversilab® system focusing on the two main isolated species, Microsporum audouinii and Trichophyton violaceum. To present a preliminary study preceding the national survey launched in 2013. Methods: A total of 51 strains of M. audouinii (50 clinical + 1 reference (ref.) strains) and 15 strains of T. violaceum (14 clinical + 1 ref. strain) originating from different locations through Belgium were included in the study. The fungal strains were first cultivated on Malt agar, then sub-cultured in Sabouraud liquid medium (Fluka). The grown mycelium was processed for DNA extraction following recommendations of the manufacturer (Ultra Clean® DNA Microbial isolation kit, MoBio laboratories). Genotypic analysis was performed using the DiversiLab® system (BioMérieux) for DNA fingerprinting and analysis. Results: Regarding M. audouinii, four different genotypic groups of strains were separated. Group 1 includes 11 strains and is only found in the Liège surroundings. Group 2 includes only one strain with little differences compared to group 1 and collected from the Liège area. These two groups may be related to each other. Group 3 contains 36 strains and the reference strain. This genotype is distributed in different Belgium locations. The last group, group 4, contains only 3 isolates sharing low similarities in comparison with the 3 other groups. Concerning T. violaceum, 6 different genotypic groups with a mixed geographical distribution were determined. Group 1 includes 8 clinical isolates and the ref. strain. The other five isolates are all different and seem not to be related to each other. Conclusion: The automated typing DiversiLab® system proved to be an easy and efficient method to investigate the molecular epidemiology of dermatophytes infections. Preliminary results of the study show that, through Belgium, several groups of isolates co-exist for M. audouinii and T. violaceum providing evidence of genetic heterogeneity. This variation can be related to acquired mutations due to environmental adaptation. Further investigations are necessary to better understand the impact of this genotypic variation. [less ▲]

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See detailStatut algofonctionnel chez les femmes belges après traitement pour néoplasie mammaire
Foidart-Dessalle, Marguerite ULiege; MICHALET, A; BOURSE, Julie ULiege et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Suppl. 1), 244

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See detailUne infiltration de plasma riche en plaquettes (PRP) pour traiter les tendinopathies rotuliennes supérieures chroniques
Kaux, Jean-François ULiege; Croisier, Jean-Louis ULiege; Bruyère, Olivier ULiege et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1),

Objective: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

Objective: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. Infiltration of platelet-rich plasma (PRP) could be a new therapy for such chronic tendinopathies. Materiel and methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10-point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. Results: Pain during daily activities significantly decreased with time (especially after 6 weeks and continued to a lesser extend up to 3 months). During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. Discussion: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol is efficient to improve symptoms of chronic jumper’s knee in patients non-responsive to classical conservative treatments. [less ▲]

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See detailGAIMS: a powerful gait analysis system satisfying the constraints of clinical routine
Pierard, Sébastien ULiege; PHAN BA, Remy ULiege; DELVAUX, Valérie ULiege et al

in Multiple Sclerosis Journal (2013, October), 19(S1), 359

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See detailRéaction inflammatoire exubérante comme effet secondaire d’une infiltration de PRP
Kaux, Jean-François ULiege; Croisier, Jean-Louis ULiege; LEONARD, Philippe ULiege et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1), 068

Introduction : Infiltrations of plasma rich platelets (PRP) represent a new treatment of tendinopathies. Currently, no side effects were reported in this indication. Case report: We report the case of a ... [more ▼]

Introduction : Infiltrations of plasma rich platelets (PRP) represent a new treatment of tendinopathies. Currently, no side effects were reported in this indication. Case report: We report the case of a 35-year-old type 1 diabetic patient with right upper patellar tendinopathy that had persisted for more than 6 months. The patient benefited from an intratendinous infiltration of 6 mL of PRP (8.105 platelets/mm3, almost no red or white blood cells) after a carefully disinfection but without local anesthesia. Typically, a standardized program of sub-maximal eccentric rehabilitation should be started 1 week after infiltration. However, the patient experienced local swelling with erythema, increased heating and pain, which appeared just underneath the patella, without biological inflammatory syndrome. In absence of septic general symptoms, no blood or wound culture were made. At 2 weeks post-infiltration, a greatly increased Doppler signal in a thicker tendon was observed by ultrasounds compared to that before infiltration, but there was no sign of infection demonstrated by either MRI or CT. However, the local inflammation did not decrease after a 3-week treatment of local cryotherapy, local and oral NSAID, and adjunct use of colchicine 1 mg. Thus, an insidious infection was suspected, even though there was no evidence of biological inflammatory syndrome or sign of infectious lesion on imagery examination. Antibiotic therapy (rifampicine 600 mg + minocycline 100 mg), was initiated for three months. Due to a lack of improvement via imaging and clinical examination, a 3-phase bone scintigraphy was performed. The results suggested the presence of a complex regional pain syndrome type 1. The patient benefited from classical physical therapy and concomitant pain killers. The evolution was favorable after 6 months of treatment. Discussion : Even though PRP infiltration represents a new and promising treatment for tendinopathy, more studies are needed both to verify its clinical efficacy. Moreover, implementing this innovative treatment requires caution because of potential adverse events. Thus, the balance between benefits and risks must be carefully evaluated before using this treatment, especially in patients with type 1 diabetes. [less ▲]

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See detailStrength improvement after 3months of resistance training among Parkinson's disease patients
Demonceau, Marie ULiege; rodriguez de la cruz, carlos; NAVEAU, Florence ULiege et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(s1), 196

Objectives.– To assess the feasibility and the effects of a strengthening program for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn and Yahr stage [1] < III of PD were ... [more ▼]

Objectives.– To assess the feasibility and the effects of a strengthening program for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn and Yahr stage [1] < III of PD were allocated to either 24 sessions of strength training (ST group; n = 8) or to a control group (C group; n = 6) for 3 months. Concentric knee muscle strength and a maximal cycling incremental test were performed at baseline and after training. Training consisted of progressive resistive exercises on leg press, leg extension, leg curl, between 50 and 80% of 1RM and was completed by non-instrumented exercises for trunk and upper limbs muscles. Anxiety, depression and quality of life were assessed using questionnaires. An Anova for repeated measures was used for statistical analysis. Results.– Six patients of the ST group (75%) fully completed the program. There were significant “group by time” effects for all knee muscles strength measures of less involved side (P < 0.05). A significant “group by time” effect was also found for knee flexors of the most involved side, but only at angular speed of 180°/s (P = 0.03). Patients of ST group also increased maximal aerobic power (+13%) whereas patients of C group decreased their performances (–9%; “group by time” effect, P = 0.04). No changes in anxiety, depression or quality of life could be highlighted. Conclusions.– The increase of some strength measures in ST group showed that progressive strength training counteracts strength decrease among people with Parkinson's disease. Strengthening also had a positive effect on maximal aerobic power. [less ▲]

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See detailFIPA : étude clinique et génétique à l'Hôpital "King Edward Memorial", Bombay (Mumbai) Inde
Bothra, N; Daly, Adrian ULiege; CASTERMANS, Emilie ULiege et al

in Annales d'Endocrinologie (2013, October), 74

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See detailCorrélations significatives de l'aspect en IRM haute résolution des adénomes hypophysairesà GH avant traitement
Potorac, Iulia ULiege; PETROSSIANS, Patrick ULiege; Schillo, F et al

in Annales d'Endocrinologie (2013, October), 74

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See detailUne néoplasie endocrinienne multiple particulière
Boccar, S; VROONEN, Laurent ULiege; HAMOIR, Etienne ULiege et al

in Annales d'Endocrinologie (2013, October), 74

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