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See detailDynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation
Tautz, Lutz; Vang, Torkel; Liu, Wallace et al

in FASEB Journal (2012, April), 26

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner ... [more ▼]

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner when forming a complex. Here, we show that dissociation of the LYP/CSK complex is necessary for recruitment of LYP to lipid rafts, where it down-modulates TCR-mediated signaling. Our findings may also explain the reduced TCR signaling associated with a single nucleotide polymorphism, which confers increased risk for autoimmunity and results in the expression of a LYP allele that can no longer bind CSK. Development of a potent and selective chemical probe of LYP allowed us to confirm that the observed down-modulation of TCR-induced signaling was due to the LYP catalytic activity. Our compound also represents a starting point for the development of a LYP-based treatment of autoimmunity. [less ▲]

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See detailClinical characterization of cabergoline resistant prolactinomas : a multicenter experience on 92 patients
VROONEN, Laurent ULg; Jaffrain Rea, ML; PETROSSIANS, Patrick ULg et al

in Annales d'Endocrinologie (2012, April), 73(2), 153

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See detailUN MILIEU CINÉMATIQUE POUR L'ÉLABORATION D'UNE PRAXÉOLOGIE « MODÉLISATION » DU THÉORÈME FONDAMENTAL DU CALCUL DIFFÉRENTIEL ET INTÉGRAL
Balhan, Kevin ULg

in ENSEIGNEMENT DES MATHÉMATIQUES ET CONTRAT SOCIAL ENJEUX ET DÉFIS POUR LE 21e SIÈCLE (2012, April)

The text is related to the calculus’s main theorem learning as it is studied by students in the last year of Belgium secondary school. We make an epistemological analysis of the theorem that inspired us ... [more ▼]

The text is related to the calculus’s main theorem learning as it is studied by students in the last year of Belgium secondary school. We make an epistemological analysis of the theorem that inspired us the set up of a situation composed of four mathematics statements and for which we need rectilinear movements with or without variable speeds, speeding and moving laws, areas, volumes and flows. The suggested strategies for these statements and the reactions will be analysed later. [less ▲]

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See detailEvaluation of three immunoassays for serodiagnosis of human Mycoplasma pneumoniae infection
HUYNEN, Pascale ULg; TOUSSAINT, Françoise ULg; HAYETTE, Marie-Pierre ULg et al

in Clinical Microbiology & Infection (2012, April), 18(S3), 231

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See detailExpression of specific pathways in the inflamed synovial membrane of osteoarthritis patient: Identification of new potential key intermediates
Lambert, Cécile ULg; Dubuc, Jean-Emile; Hennuy, Benoît ULg et al

in Osteoarthritis and Cartilage (2012, April), 20(Supplement 1), 56

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal ... [more ▼]

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal/reactive (N/R) and inflammatory (I) synovial membranes zones, we investigated the gene expression profiles of synovial cells from these areas and identified differentially regulated pathways. <br />Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling between N/R and I areas was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I areas was based on paired t-test where N/R and I were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Western blot was performed to confirm certain intermediate expression. <br />Results: From among 47000 probes, 17500 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 896 differentially expressed genes between N/R and I zones were identified. Among these, 576 genes were upregulated (I/NR > 1.5) and 320 downregulated (I/NR < 0.75). With Ingenuity Pathways Analysis, a significant number of the top ranking differentially expressed genes were identified as inflammatory, Wnt and angiogenic pathways. Interleukin (IL)-6 and -8, chemokines (CXCL1, CXCL2, CXCL5, CXCL6, CXCL16) and arachidonate 5-lipoxygenase (ALOX5) were identified as the most upregulated in I zones in the inflammatory pathway. Interestingly, the alarmin S100A9 was found strongly upregulated in this pathway. Wnt5A and LRP (Low density lipoprotein receptor-related protein) 5 were upregulated whereas FZD (Frizzled homolog) 2 and DKK (dickkopf homolog) 3 were downregulated in the Wnt signaling pathway. Finally, stanniocalcin (STC)-1, an intermediate in angiogenesis was identified as the most upregulated gene in I zones compared to N/R zones. This difference of expression was confirmed at the protein level. <br />Conclusions: Using a unique culture system, this study is the first to identify different expression pattern between two areas of synovial membrane from the same OA patient. These differences concern several key pathways involved in OA pathogenesis, i.e. inflammation, Wnt and angiogenesis. This analysis also provided interesting information regarding new potent intermediates as S100A9 and STC-1. They could be potential targets for chondroitin sulfate, one of the most used molecules in the management of OA. New experiments are being perfomed at the moment to elucidate the potential effect of this molecule on these specific differentially expressed genes in the same culture system. [less ▲]

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See detailTHE RESPONSE OF ACETOBACTER SENEGALENSIS TO STRESSORS: A STUDY TOWARDS IMPROVEMENT OF VINEGAR STARTER PRODUCTION
Shafiei, Rasoul ULg; Thonart, Philippe ULg

in Acetic Acid Bacteria (2012, April)

Acetic acid bacteria encounter various harsh conditions during acetic acid fermentation. Ethanol as the main substrate and acetic acid as the major product at low pH can influence deeply on the cellular ... [more ▼]

Acetic acid bacteria encounter various harsh conditions during acetic acid fermentation. Ethanol as the main substrate and acetic acid as the major product at low pH can influence deeply on the cellular functions of acetic acid bacteria. In previous studies in CWBI, Acetobacter senegalensis was used for production of dried vinegar starters; however the impact of stressors (ethanol and acetic acid) on A. senegalensis remained unclear. In this study, different techniques such as flow cytometry, culturability on solid medium and 2-DiGE were used comparatively to investigate the effect of carbon sources of inoculum media on the tolerance of A. senegalensis to stressors. Analysis of respiration system by flow cytometric methods showed that the presence of 2% (v/v) acetic acid in inoculum medium, in one hand, causes 80% of cells to continue to do respiration after a sudden exposure to 1- 3% (v/v) acetic acid in stress media while 89.7% of cells grown in glucose appeared as dead cells after an abrupt exposure to 3%(v/v) of acetic acid. On the other hand, 59.2% and 49.33% of cells grown in the presence of 2% (v/v) of acetic acid could maintain their entire membrane integrity after exposure to 1% and 3% (v/v) of acetic acid, respectively. Inoculum medium contained 5% (v/v) of ethanol as a carbon source enabled about 90% of cells to keep their growing capacities after a sudden exposure to 3% acetic acid. In contrast, just 40% of cells grown in glucose as a carbon source maintained their culturability on solid medium after exposure to 1% acetic acid. A similar profile of culturability was observed for the cells grown in 5% (v/v) ethanol or 2% (v/v) of acetic acid. A proteomic approach (2-DiGE) was used to analyze proteins expressed in the presence of different carbon sources. Differentially expressed proteins were mainly associated with energy metabolism, carbohydrate metabolisms, folding, sorting and degradation processes. The relative abundance of proteins was extensively different for cell grown in glucose compared with protein contents of cells grown in ethanol or acetic acid. In conclusion, production of a cost effective vinegar starter needs a qualified biomass which tolerates ethanol and acetic acid. Tolerance of A. senegalensis to acetic acid depends to a great extent on the composition of the medium which cells grow in. In spite of low adaption to acetic acid for cell grown in glucose, using ethanol or acetic acid in inoculum media renders a physiological state in A. senegelensis which enables it to cope with higher concentration of acetic acid readily, this biomass has a potential to be used as a starter [less ▲]

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See detailAMICE: erste internationale Modellrechnung der Maas
Becker, Bernhard; Patzke, Simone; Detrembleur, Sylvain ULg et al

in Forum für Hydrologie und Wasserbewirtschaftung (2012, March 22), 12(31), 165-170

Im Rahmen des AMICE-Projektes wurde eine erste zusammenhängende internationale Modellrechnung für den gesamten Flusslauf der Maas inklusive des Nebenflusses Rur durchgeführt. Dazu wurden die in den ... [more ▼]

Im Rahmen des AMICE-Projektes wurde eine erste zusammenhängende internationale Modellrechnung für den gesamten Flusslauf der Maas inklusive des Nebenflusses Rur durchgeführt. Dazu wurden die in den Anrainerstaaten Frankreich, Belgien, Deutschland und der Niederlande vorgehaltenen numerischen Modelle verwendet. Die Randbedingungen dieser Modelle wurden in einem iterativen Prozess abgeglichen. Die Ergebnisse der zusammenhängenden Simulation tragen zunächst zu einem besseren Systemverständnis bei. Im weiteren Verlauf des Projektes fließen sie in eine Risikobetrachtung ein und werden zur Bewertung von Maßnahmen zur Reduzierung des Hochwasserrisikos vor dem Hintergrund zu erwartender Änderung der Bemessungsgrößen infolge einer erwarteten Klimaänderung herangezogen. [less ▲]

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See detailLA FALSIFICATION DES MEDICAMENTS
Marini Djang'Eing'A, Roland ULg

in Forum Pharmaceutique (2012, March 16), -(-), 16

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See detailHigh-resolution spectropolarimetric observations of hot subdwarfs
Petit, P.; Van Grootel, Valérie ULg; Bagnulo, S. et al

in Leaflet - Astronomical Society of the Pacific (2012, March 01), 452

We report on high-resolution spectropolarimetric observations of the hot subdwarf stars HD 76431 and Feige 66, using the ESPaDOnS echelle spectropolarimeter at CFHT. We compute cross-correlation Stokes I ... [more ▼]

We report on high-resolution spectropolarimetric observations of the hot subdwarf stars HD 76431 and Feige 66, using the ESPaDOnS echelle spectropolarimeter at CFHT. We compute cross-correlation Stokes I and V line profiles to enhance the signal-to-noise ratio. We then average all available cross-correlation profiles of each star to further decrease the noise level. Although both targets were previously reported to host kilo-gauss magnetic fields, we do not derive any evidence of large-scale photospheric fields from our sets of observations, in spite of tight error bars on the longitudinal field of the order of 60 gauss for HD 76431 and 200 gauss for Feige 66. A new analysis of FORS1 observations of HD 76431, which provided the basis for the original claim of field detection, confirms the absence of any detectable Zeeman signature, with an error bar of about 100 gauss on the longitudinal magnetic field. [less ▲]

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See detailAutomata-Based Symbolic Representations of Polyhedra
Boigelot, Bernard ULg; Brusten, Julien ULg; Degbomont, Jean-François ULg

in Lecture Notes in Computer Science (2012, March), 7183

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See detailStrontium ranelate reduces the number of radiological or radioclinical progressors in patients with primary knee osteoarthritis
Reginster, Jean-Yves ULg; Chapurlat, R; Christiansen, C et al

in Osteoporosis International (2012, March), 23(S2), 366-367

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See detailWhat are the most important medication attributes for patients with osteoporosis ? Results from a qualitative study
Hiligsmann, Mickaël ULg; Van Durme, C; Geusens, P et al

in Osteoporosis International (2012, March), 23(S2), 81-82

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See detailEfficacy of once-yearly zoledronic acid 5 mg in men with osteoporosis with different levels of serum total testosterone
Boonen, S; Reginster, Jean-Yves ULg; Kaufman, JM et al

in Osteoporosis International (2012, March), 23(S2), 79-80

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See detailDenosumab treatment of postmenopausal women with osteoporosis for 6 years : results from the first 3 years of the freedom extension
Papapoulos, S; Brown, JP; Chapurlat, R et al

in Osteoporosis International (2012, March), 23(S2), 76

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See detailAMP-activated protein kinase controls liposaccharide-induced hyperpermeability
Castanares-Zapatero, Diego; Overtus, M; Communi, Didier et al

in Critical Care (2012, March), 16(suppl 1), 17

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK ... [more ▼]

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK) has been shown to modulate cytoskeleton and could mediate endothelial permeability. Our hypothesis is that AMPK controls sepsis-induced hyperpermeability in the heart and is involved in septic cardiomyopathy. Sepsis was induced by intraperitoneal injection of liposaccharide, 10 mg/kg (LPS). Alpha-1 AMPK knockout mice (α1KO) were compared with wild-type. Vascular permeability was characterized by Evans blue extravasation. Inflammatory cytokine mRNA expression was determined by qPCR analysis. Left ventricular mass was assessed by echocardiography. In addition, to emphasize the beneficial role of AMPK on heart vascular permeability, AMPK activator (acadesine) was administered to C57Bl6 mice before LPS injection. The ANOVA test with Bonferroni's post hoc test and the log-rank test were used. P < 0.05 was considered as significant. Increased cardiac vascular permeability was observed in the LPS group in comparison to untreated animals (2.5% vs. 16%; P < 0.05). The α1KO mice exhibited an increase vascular permeability after LPS injection in comparison to wild-type mice (41.5% vs. 16%; P < 0.05). α1KO animals had a significant mortality increase after LPS injection (70% vs. 10%; P < 0.05). LPS markedly induced the production of proinflammatory cytokines (TNFα, IL-1β, IL-6) that were significantly higher in the α1KO animals. More importantly, LPS treatment leads to an increased left ventricular mass in the α1KO mice within 24 hours, suggesting the onset of edema. Finally LPS-induced vascular hyperpermeability was greatly reduced after AMPK activation by acadesine (13.2% vs. 40%; P < 0.05). AMPK importantly regulates cardiac vascular permeability and could control the sepsis-induced cardiomyopathy. AMPK could represent a new pharmacological target of sepsis. [less ▲]

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of nonvertebral fractures in high-risk postmenopausal osteoporosis population
Ellis, A; Jansen, J; Luo, X et al

in Osteoporosis International (2012, March), 23(S2), 64-65

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See detailEffect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
Bruyère, Olivier ULg; Zegels, Brigitte ULg; LEONORI, Lorenzo ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 362-363

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See detailPerception, knowledge and use by general practitioners of Belgium of the FRAX tool
Bruyère, Olivier ULg; Nicolet, Delphine ULg; Compère, Stéphanie et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 363-364

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See detailLong-term (3 years) reproducibility for the radiological assessment of knee osteoarthritis
DEROISY, Rita ULg; Bruyère, Olivier ULg; Gensburger, Deborah et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 219-220

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See detailRadiological and clinical profil of osteoarthritic patients undergoing of total joint replacement
Neuprez, Audrey ULg; François, Garance ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 129-130

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See detailAssessment of joint space narrowing in knee osteoarthritis has good long-term intercentre reproducibility when read in pairs with a semi-automated device
Gensburger, Deborah; DEROISY, Rita ULg; Arlot, Monique et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 247-248

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See detailCost-effectiveness of bazedoxifene compared with raloxifene in the treatment of postmenopausal osteoporotic women
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 312-313

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See detailAn economic evaluation of strontium ranelate for the treatment of male osteoporosis
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 305-306

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See detailSevere prevalent vertebral fractures predict subsequent vertebral and nonvertebral fractures: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 361-362

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See detailSeverity of incident vertebral fracture and future fracture risk: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 60-61

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See detailStructure modifying effects of strontium ranelate in knee osteoarthritis
Reginster, Jean-Yves ULg; Chapurlat, R; Christiaensen, C et al

in Osteoporosis International (2012, March), 23(S2), 58-59

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See detailDifference between total and intact assays for N-terminal propeptide of type I procollagen in renal impaired patients
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; ROUSSELLE, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Supplement 2), 339

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See detailEstablishment of parathyroid hormone (PTH) reference on 10 different assay kits: impact of the recruitment of the population
CAVALIER, Etienne ULg; SOUBERBIELLE, Jean-Claude

in Osteoporosis International (2012, March), 23(Supplement 2), 360

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See detailStrontium ranelate uncouples bone formation from bone resorption in male osteoporotic patients
COLLETTE, Julien ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2012, March), 23(S2), 365-366

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See detailStrontium ranelate and risk of venous thromboembolism (VTE) : an update of a retrospective cohort study in the UK general practice research database (GPRD)
Cooper, C; Deltour, N; Speirs, C et al

in Osteoporosis International (2012, March), 23(S2), 364-365

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See detailEstimation of genetic parameters for methane indicator traits based on milk fatty acids in dual purpose Belgian blue cattle
Kandel, Purna Bhadra ULg; Soyeurt, Hélène ULg; Gengler, Nicolas ULg

in Communications in Agricultural and Applied Biological Sciences (2012, February 10), 77(1), 21-25

The genetic parameters of CH4 indicators were estimated by single trait test-day models from 16,825 records collected on Walloon Dual Purpose Belgium Blue cows in their first 3 lactations. Fatty acid ... [more ▼]

The genetic parameters of CH4 indicators were estimated by single trait test-day models from 16,825 records collected on Walloon Dual Purpose Belgium Blue cows in their first 3 lactations. Fatty acid based CH4 indicators published in the literature were predicted from milk mid-infrared spectra using 597 calibration samples. For the indicator showing the highest link (R2 =0.88) with SF6 CH4 data, the average daily heritability was 0.21, 0.20 and 0.10 for each lactation, respectively. The sire genetic variability was on average 2.82 kg2 of CH4 per lactation. The genetic difference between the sires having cows eructing higher and lower CH4 was 10 kg of CH4 averaged per lactation. In conclusion, CH4 indicators can be predicted by MIR and the genetic variability of these traits seems to exist. [less ▲]

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See detailApport des troponines T et I ultrasensibles dans le diabète
LE GOFF, Caroline ULg; LAURENT, Terry ULg; GARWEG, Christophe ULg et al

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2012, February), 27(1), 40

Introduction : Le diabète atteint environ 3% de la population française. Or, cette maladie expose à l'apparition précoce de complications cardiovasculaires. Les troponines de nouvelles générations ... [more ▼]

Introduction : Le diabète atteint environ 3% de la population française. Or, cette maladie expose à l'apparition précoce de complications cardiovasculaires. Les troponines de nouvelles générations hautement sensibles pourraient être un bon outil diagnostic pour mettre en évidence des macroou micro-angiopathies non diagnostiquée chez ces patients. Le but de notre étude était de comparer la performance de la troponine T ultrasensible (hsTnT) (Roche Diagnostic) avec la troponine I ultrasensible (TnI II) (Abbott Diagnostic) chez le sujet diabétique. Matériel et méthodes : Vingt patients diabétiques (âge moyen : 52.6 ± 8.4 ans) ont été sélectionnés sur le critère d’un taux d’hémoglobine glyquée (HbA1c) élevé. Ces sujets ont été comparés à vingt sujets contrôles d’âge moyen : 60.05 ± 2.86 ans. Les patients atteints d’insuffisance rénale et d’affections cardiovasculaires ont été exclus. Les analyses ont été réalisées sur du plasma hépariné lithium. La hsTnT a été dosée par électrochemiluminescence sur le Modular E (Roche Diagnostic). Abbott utilise des microparticules chemiluminescentes pour le dosage de la TnI II sur l’ARCHITECT i. Résultats : Les sujets diabétiques ont un taux plasmatique de hsTnT représenté par les valeurs suivantes [médiane (1er quartile, 3ème quartile)] : 0,007 (0,03 ; 0,018) ng/mL ; alors que les sujets contrôles négatifs présentent les valeurs suivantes : 0,003 (0,003 ; 0,004) ng/mL. La différence de taux de hsTnT observée entre ces 2 populations est statistiquement significative (p = 0,000922). Pour la TnI II, on observe un taux plasmatique de: 0,004 (0,003 ; 0,075) ng/mL chez les sujets diabétiques et 0,002 (0,001 ; 0,005) ng/mL chez les sujets contrôles. La différence de taux de TnI II observée entre ces 2 populations n’est pas statistiquement significative (p > 0,005). Discussion-conclusion : Au décours d’un diabète, il apparait que les taux de hsTnT sont augmentés de façon significative par rapport au groupe des contrôles négatifs. Si les taux hsTnT augmentent chez le diabétique, il semblerait normal qu’il en soit de même pour la TnI II, vu que ces deux marqueurs sont intimement liés. Nous ne l’avons pas observé mais ceci peut être du à la plus faible performance analytique du dosage de la TnI II utilisé. Cette libération de hsTnT dans le sang peut être due aux micro- et macro-angiopathies au niveau des coronaires induites au cours d’un diabète. [less ▲]

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See detailA candidate cell of origin for cervical cancer
Herfs, Michael ULg; Yamamoto; Laury et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2012, February), 25(2), 4-552

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See detailDynamic Prediction of Energy Delivery Capacity of Power Networks : Unlocking the Value of Real-Time Measurements.
Schell, Peter; Jones, Lauren; Mack, Philippe et al

in Proceedings of the third IEEE PES Conference on Innovative Smart Grid Technologies (2012, January)

This paper describes recent advances in prediction software using advanced data-mining tools, and shows how this can significantly increase the operational value of the data gathered. These new tools ... [more ▼]

This paper describes recent advances in prediction software using advanced data-mining tools, and shows how this can significantly increase the operational value of the data gathered. These new tools allow for new operational procedures to be defined that increase the usages of the network without decreasing security of supply. We will use the example of dynamic line rating, i.e. determining the thermal rating of an overhead line based on real-time environmental parameters (temperature, wind speed & direction and solar radiation) to highlight how the use of numerical data-mining tools can help us reliably predict future behavior of power networks. [less ▲]

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See detailLa nécessité d'un inventaire du patrimoine culturel immatériel
Lempereur, Françoise ULg

in Géants d'ici et d'ailleurs (2012, January), (6-7), 24-30

Destinée essentiellement aux institutions et groupements qui ont en charge la sauvegarde du patrimoine culturel immatériel, cette présentation rapide justifie l'inventorisation de ce patrimoine, en ... [more ▼]

Destinée essentiellement aux institutions et groupements qui ont en charge la sauvegarde du patrimoine culturel immatériel, cette présentation rapide justifie l'inventorisation de ce patrimoine, en définit les responsabilités et propose une méthodologie de collectage et de mise à disposition publique des contenus [less ▲]

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See detailCampagnes de sensibilisation au dépistage du diabète de type 2 dans les pharmacies. Comparaison de deux approches : glycémie capillaire et grille Findrisc
Böhme, P; Agrinier, N; Badia, M et al

in Diabètes & Métabolism (2012), 38(2), 7

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See detailCorals of the Upper Viséan Microbial-Sponge-Bryozoan-Coral Bioherm of Kongul Yayla (Taurides, S Turkey), Palaeobiogeographic Relations
Denayer, Julien ULg

in Turkish Association of Petroleum Geologists, Special Publication (2012), 6

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See detailNodal staging of head and neck squamous cell carcinomas : impact of a dedicated PET/CT protocol.
MINON, AL.; CABAY, Jean-Evrard ULg; DEMEZ, Pierre ULg et al

in Journal of Nuclear Medicine (The) (2012), 53(SUPPL), 1354

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See detailLa bone sialoproteine: un facteur clé dans la pathogénie de l'arthrose
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Delcour, Jean-Pierre et al

in Revue du Rhumatisme (2012), 79(S), 106

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See detailPhase Change Memories challenges: A material and process perspective
Maitrejean, S.; Ghezzi, G.; Gourvest, E. et al

in IEEE International Interconnect Technology Conference (2012)

Among all the new memories concepts, Phase Change Memories (PCM) is one of the most promising. However, various challenges remain. This paper reviews the materials and processes required to face these ... [more ▼]

Among all the new memories concepts, Phase Change Memories (PCM) is one of the most promising. However, various challenges remain. This paper reviews the materials and processes required to face these challenges. As an example, attention will be made on the effect of Phase change material composition on stability of the amorphous phase i.e. on the retention of the information. Additionally, it is showed how specific processes such as CVD or ALD can be developed in order to minimize the current required to amorphize the phase change material i.e. to reset the device. Finally, with the perspectives of the advanced integration nodes, experimental results on the effect of scaling on phase transformation are presented and discussed. © 2012 IEEE. [less ▲]

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See detailIsoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation
Labied, Soraya ULg; Delforge, Yves ULg; Blacher, Silvia ULg et al

in Journal of Assisted Reproduction & Genetics (2012), 28(11), 1009

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See detailLANDSAFE: LANDING SITE RISK ANALYSIS SOFTWARE FRAMEWORK
Schmidt, Ralph; Bostelmann, Jonas; Cornet, Yves ULg et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2012), XXXIX(B4), 505-510

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful ... [more ▼]

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful landing a careful risk analysis has to be carried out. This is comprised of identifying favorable target areas and evaluating the surface conditions in these areas. Features like craters, boulders, steep slopes, rough surfaces and shadow areas have to be identified in order to assess the risk associated to a landing site in terms of a successful touchdown and subsequent surface operation of the lander. In addition, global illumination conditions at the landing site have to be simulated and analyzed. The Landing Site Risk Analysis software framework (LandSAfe) is a system for the analysis, selection and certification of safe landing sites on the lunar surface. LandSAfe generates several data products including high resolution digital terrain models (DTMs), hazard maps, illumination maps, temperature maps and surface reflectance maps which assist the user in evaluating potential landing site candidates. This paper presents the LandSAfe system and describes the methods and products of the different modules. For one candidate landing site on the rim of Shackleton crater at the south pole of the Moon a high resolution DTM is showcased. * Corresponding [less ▲]

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See detailRapamycin Prevents Experimental Sclerodermatous Chronic Graft-versus-Host Disease in mice
Belle, Ludovic ULg; Binsfeld, Marilène ULg; DUBOIS, Sophie ULg et al

in Belgian Journal of Hematology (2012), Abstracts book(Supplement of 27th General Meeting of the Belgian Hematological Society), 14

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See detailComputer-based monitoring of global cardiovascular dynamics during acute pulmonary embolism and septic shock in swine
Revie, JA; Stevenson, D; Chase, JG et al

in Critical Care (2012), 16 (Suppl 1)

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See detail139 DOES QUALITY OF RADIOTHERAPY PREDICT OUTCOMES OF MULTICENTRE CLINICAL TRIALS? THE EORTC RADIATION ONCOLOGY GROUP EXPERIENCE.
Fairchild, Alysa; Collette, Laurence; Hurkmans, Coen W. et al

in Radiotherapy & Oncology (2012), 102

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See detailVariability of insulin sensitivity during the first 4 days of critical illness
Pretty, Christopher ULg; Le Compte, A; Chase, JG et al

in Critical Care (2012), 16 (Suppl 1)

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See detailEP-1420 ADAPTIVE CLINICAL COMMISSIONING OF MONACO VMAT: MAXIMIZING EFFICACY WITHOUT SACRIFICING SAFETY
GULYBAN, Akos ULg; Oltenau, A. M. L.; Vercauteren, T. et al

in Radiotherapy & Oncology (2012), 103

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See detailCFD-gestütztes Design von Drehscheibenextraktoren
Aksamija, E; Weinländer, C; Pfennig, Andreas ULg et al

in Chemie Ingenieur Technik (2012), 84(8), 1262

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See detailOC-0501 IRRADIATION OF THE LEFT VENTRICLE OF THE HEART IS CORRELATED WITH POST-TREATMENT DYSPNEA IN NSCLC PATIENTS
Nalbantov, G.; De Ruysscher, Dirk; Vandecasteele, K. et al

in Radiotherapy & Oncology (2012), 103

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See detailAntioxidant and anti-inflammatory like properties of benzoic acid analogs on the oxidant response of neutrophils: structure/redox potential relationship study.
Franck, Thierry ULg; Mouithys-Mickalad, Ange ULg; Robert, Thierry ULg et al

in Free Radical Biology & Medicine (2012), 53(supplement 1),

We investigated the antioxidant capacity of phenolic acid derivatives by measuring their capacity to prevent ABTS oxidation and evaluating their anti-inflammatory like-properties on the oxidant response ... [more ▼]

We investigated the antioxidant capacity of phenolic acid derivatives by measuring their capacity to prevent ABTS oxidation and evaluating their anti-inflammatory like-properties on the oxidant response of neutrophils, especially on superoxide anion production and the activity of myeloperoxidase (MPO), an oxidant enzyme present and released by the primary granules of neutrophils. The superoxide anion production by PMA-stimulated neutrophils was measured by lucigenin-enhanced chimiluminescence (CL) and the activity of MPO by SIEFED to study the potential interaction of a molecule with the enzyme without interferences due to medium. The antioxidant and anti-inflammatory activities of the phenolic compounds were correlated to their redox potentials measured by voltammetry method, and discussed in relation to their molecular structure. The ability of the phenolic molecules to decrease ABTS oxidation and CL production was inversely correlated to their redox potential increasing as follows: propyl gallate > gallic acid > caffeic acid > 3,4-dihydroxybenzoic acid > ferulic acid > syringic acid > 2,6-dihydroxybenzoic acid > salicylic acid > benzoic acid. The number of hydroxyl groups (3) and their position (catechol) were essential for the efficacy of the molecules as stoichiometric antioxidants or scavengers. On MPO activity, the inhibitory capacity of the molecules was not really correlated with their redox potential and increased as follows: gallic acid > caffeic acid > 2,6-dihydroxybenzoic acid > propyl gallate > ferulic acid = syringic acid > 3,4-dihydroxybenzoic acid = salicylic acid > benzoic acid. The number of OH groups and the elongation of the carboxyl group were essential for the inhibition of MPO activity, probably by facilitating the interaction with the MPO active site or structure. The redox potential measurement seems to be a good technique to select stoichiometric antioxidants, but not anti-catalytic ones. [less ▲]

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See detail(18F)FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas : correlation with histopathology.
WITHOFS, Nadia ULg; SIGNOLLE, N.; NZARAMBA, EM. et al

in Journal of Nuclear Medicine (The) (2012), 53(SUPPL), 1647

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See detailLa contribution du Centre européen d'archéométrie (ULg) à la base de données internationale "Digital collaboratory for cultural-historiocal dendrochronology in the Low Countries (DCCD)
Hoffsummer, Patrick ULg; Lambert, Georges-Noël

in Archeologia Mediaevalis, archéologie du Moyen Âge et des Temps modernes dans les trois régions belges et les pays limitrophes (2012), 35

This paper is a description of the dendrochronological metadata data of University of Liège we can consult on the International Digital collaboratory for Cultural-historical Dendrochronology in the Low ... [more ▼]

This paper is a description of the dendrochronological metadata data of University of Liège we can consult on the International Digital collaboratory for Cultural-historical Dendrochronology in the Low-Countries (DCCD, on line). It also mention the process used to realise this project with the help of a new software "Dendron IV". [less ▲]

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See detailLes organisations d'aide et soins à domicile: des entreprises à haute valeur ajoutée
Defourny, Jacques ULg

in La Revue de l'Aide et des Soins à Domicile (2012), 131(mai-juillet), 24-27

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See detailExperimental quantification of Wolff's law in an in vivo loading model
Ruffoni, Davide ULg; Schulte, F. A.; Lambers, F. M. et al

in BONE (2012), 50(1), 125-125

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See detailA Search For 15NH2 Lines In Comet C/2002 T7 (LINEAR)
Rousselot, Philippe; Pirali, O.; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2012), 44

The determination of isotopic ratios in comets is of primary importance for a good understanding of their origin and the formation of solar system. The [SUP]14[/SUP]N/[SUP]15[/SUP]N ratio is an ... [more ▼]

The determination of isotopic ratios in comets is of primary importance for a good understanding of their origin and the formation of solar system. The [SUP]14[/SUP]N/[SUP]15[/SUP]N ratio is an interesting tracer, because of its variability among various solar system bodies. So far it has only been measured in bright comets through optical observations of the CN radical (Arpigny et al., 2003; Manfroid et al., 2009) and millimeter observations of HCN (Bockelée-Morvan et al., 2005, 2008). The measurements give for both species the same non-terrestrial isotopic composition ([SUP]14[/SUP]N/[SUP]15[/SUP]N≈150 in comets versus 272 in the Earth atmosphere), but HCN and CN are minor species. In order to get a determination of this ratio in another molecule we have searched for [SUP]15[/SUP]NH[SUB]2[/SUB] lines in a high-resolution and high signal-to-noise ratio spectrum of comet C/2002 T7 (LINEAR) obtained with the UVES spectrometer at the VLT ESO 8-m telescope (Hutsemékers et al., 2008). This work is based on a new laboratory experiment conducted with the AILES beamline spectrometer at synchrotron SOLEIL to determine the [SUP]15[/SUP]NH[SUB]2[/SUB] wavelengths by Fourier transform spectroscopy. We will present the first results obtained from these data, which have allowed to search for the first time [SUP]15[/SUP]NH[SUB]2[/SUB] emission lines in a comet. References: Arpigny et al., 2003, Science, 301, 1522 Bockelée-Morvan et al.,2005, in Comets II, ed. M. C. Festou, H. U. Keller, & H. A. Weaver (Tucson: Univ. Arizona Press), 391 Bockelée-Morvan et al., 2008, ApJ, 679, L49 Hutsemékers et al., 2008, A&A 490, L31 Manfroid et al., 2009, A&A 503, 613 [less ▲]

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See detailParathyroid hormone but not bisphosphonate therapy interferes with the local mechanoregulatory mechanism in trabecular bone
Schulte, F. A.; Weigt, C.; Ruffoni, Davide ULg et al

in BONE (2012), 50(1), 40-40

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See detailOcytocine, hormone altruiste pleine de promesses ?
Scantamburlo, Gabrielle ULg

in Encéphale (L') (2012)

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See detailAcute exposure to blue-enriched light impacts on melatonin and sleep in humans
Chellappa, Sarah Laxhmi ULg; Steiner, Roland; Oelhafen, Peter et al

in Journal of Sleep Research (2012)

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See detailDo root-emitted volatile organic compounds attract wireworms?
Barsics, Fanny ULg; Latine, Rémi ULg; Gfeller, Aurélie ULg et al

in Communications in Agricultural and Applied Biological Sciences (2012), 77(3), 561-567

Wireworms are the soil dwelling larvae of click beetles (Coleoptera: Elateridae). Their importance as crop pests increases since the efficient chemical means to control them cannot be considered anymore ... [more ▼]

Wireworms are the soil dwelling larvae of click beetles (Coleoptera: Elateridae). Their importance as crop pests increases since the efficient chemical means to control them cannot be considered anymore. Therefore, many integrated pest management strategies have been investigated in the past few years. Most of them rely on the understanding of the ecology of the click beetles during their whole life cycle. We focus our work on the chemical ecology of wireworms, more precisely on the root-emitted volatile organic compounds (VOCs) that might intervene in the food-searching process of the larvae by helping them to find a suitable host-plant or by acting as key factors in the belowground defence mechanism of the plant. Here, we present our first results of dual-choice orientation tests in olfactometric pipes. Wireworms (Agriotes sordidus Illiger) were submitted individually to a variety of olfactory baits ranging from entire barley roots (Hordeum vulgare L. var. Quench) to isolated VOCs identified as part of the emitting profile. The latter was described thanks to HS-SPME samplings and GC-MS analysis, for roots grown in the exact same conditions as for the olfactometric experimentations with entire roots. Most of the experimentations gave significant results. When confronted to volatiles emitted by entire roots, wireworms significantly orientated towards the bait (χ²-goodness-of-fit test, χ²=8, P-value=0.005). This result allowed us to follow up with the same device and to progressively vary the nature of the baits. Our protocol should be used for other plant-wireworm species combinations. Our results should be taken into account in varietal selection, in crop rotation, or in trapping systems aiming at the reduction of the populations of wireworms. [less ▲]

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See detailStatus on the transversity parton distribution: the dihadron fragmentation functions way
Courtoy, Aurore ULg; Bacchetta, Alessandro; Radici, Marco

in PoS - Proceedings of Science (2012), QNP2012

We report on the extraction of dihadron fragmentation functions (DiFF) from the semiinclusive production of two hadron pairs in back-to-back jets in e+e- annihilation. A nonzero asymmetry in the ... [more ▼]

We report on the extraction of dihadron fragmentation functions (DiFF) from the semiinclusive production of two hadron pairs in back-to-back jets in e+e- annihilation. A nonzero asymmetry in the correlation of azimuthal orientations of opposite π+π− pairs is related to the transverse polarization of fragmenting quarks through a significant polarized DiFF. A combined analysis of this asymmetry and the spin asymmetry in the SIDIS process ep↑→e′(π+π−)X has led to the first extraction of the u and d-flavor transversity parton distribution function in the framework of collinear factorization. [less ▲]

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See detailL'échec de la communication et les potentialités narratives
Servais, Christine ULg

in Traces (2012), 20

Cet article s'intéresse à la relation entre narration et communication. Il suggère que la frontière réel/fiction serait non pertinente relativement à une « efficacité » ou à une « réussite » de la ... [more ▼]

Cet article s'intéresse à la relation entre narration et communication. Il suggère que la frontière réel/fiction serait non pertinente relativement à une « efficacité » ou à une « réussite » de la communication. Plus précisément, il suppose que la non pertinence de l’opposition réel/fiction est au cœur de la réussite de la communication elle-même : telle est la seconde thèse. Encore faudra-t-il auparavant s’être entendu sur ce qu’est une communication « réussie », et pour ce faire reconsidérer cette question, en établissant une relation de dépendance réciproque entre ses « rites », qui cadrent et limitent l’interaction ainsi que l’a montré Goffman, et ses « risques » que sont la possibilité du dérapage, de la sortie du cadre, voire la difficulté à établir un cadre. C'est là la première thèse : pas de rites sans risques, et ce non pas parce l’échec ou l’accident pourraient toujours survenir, mais parce qu’ils sont constitutifs du rite lui-même. En définitive, cet article s'attache à montrer que l’échec de la communication est l’une des conditions de sa réussite, et qu’il est au cœur de la possibilité de la narration ainsi que de sa lecture. [less ▲]

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See detailUniversal functions in the study of the relative orbital dynamics
Condurache, Daniel; Martinusi, Vladimir ULg

in Advances in the Astronautical Sciences (2012), 145

The closed-form solution to the problem of the relative motion in gravitational fields is expressed with the help of the universal functions. The full nonlinear model of the relative motion is considered ... [more ▼]

The closed-form solution to the problem of the relative motion in gravitational fields is expressed with the help of the universal functions. The full nonlinear model of the relative motion is considered, and no linearization or approximation assumptions are made. The results are free of singularities and they hold for any reference and targeted orbits, as well as for any time scale. A unified way to propagate the relative orbit with respect to time is introduced, by making use of the solution to a generalized Kepler equation. [less ▲]

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See detailCO2 total column retrieval by mid-IR FT Spectroscopy
Buschmann, M; Dohe, S; Mahieu, Emmanuel ULg et al

in Geophysical Research Abstracts (2012), 14

Over the last decade ground-based remote sensing measurements of CO2 have been established as an important component in the global observing system for greenhouse gases. Since 2004 the Total Carbon Column ... [more ▼]

Over the last decade ground-based remote sensing measurements of CO2 have been established as an important component in the global observing system for greenhouse gases. Since 2004 the Total Carbon Column Observing Network (TCCON) sites have provided CO2 retrievals in the near-IR region. CO2 can also be retrieved in the mid-IR spectral region and it would be of great benefit to use these spectra to produce CO2-data of sufficient precision. With this, 20 years of additional observations obtained in the mid-IR at a suite of FT-IR sites of the Network Detection of Atmospheric Composition Change (NDACC) will be accessible. We investigated a series of different CO2 microwindows in the mid-IR spectral region and present results from the most promising candidates for a showcase FT-IR site (Ny Alesund). Limitations of the approach are outlined and the feasibility of a future Mid-IR CO2-product of sufficient precision is discussed. [less ▲]

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See detailInfluence of the shielding currents lengthscale and anisotropy effects on the magnetic flux profiles of high-temperature superconductors
Vanderbemden, Philippe ULg; Lovchinov, Vassil

in Journal of Physics: Conference Series (2012), 398

The so-called "magnetic flux profile" AC inductive technique is a powerful method for determining the critical current density Jc of bulk superconductors. In this work we aim at reporting analytical ... [more ▼]

The so-called "magnetic flux profile" AC inductive technique is a powerful method for determining the critical current density Jc of bulk superconductors. In this work we aim at reporting analytical expressions for magnetic flux profiles of superconducting rectangular samples exhibiting a critical current density anisotropy. The results are used for examining the error resulting from approximating a rectangular cross-section by an "infinite cylinder" or "infinite slab" geometry. It is found that such approximations can lead to an artificial curvature of the flux profiles and errors of 10%–20% in the determination of Jc. Next, the effects of how planar defects (cracks, platelet boundaries,...) affect the magnetic flux profile signal are discussed. It is found that the magnetic flux profiles are much sensitive to the lengthscale of shielding currents, thereby providing means of investigation of the typical size of induced current loops in bulk superconductors. Finally some illustrative flux profile data measured on a bulk, large grain melt-processed YBCO single domain exhibiting Jc anisotropy are presented and discussed in relation with theoretical predictions. [less ▲]

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See detailPh Ib/II study of BKM120 plus trastuzumab in patients with trastuzumab-resistant HER2+ advanced breast cancer
Pistilli, Barbara; Urruticoechea, Ander; Chan Stephen et al

in Annals of Oncology (2012), 23(supplément 9), 116

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See detailConnectivity within the default mode network is related to working memory performance in young but not elderly healthy adults
Yakushev, Igor; Chételat, Gael; Fischer, Florian et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2012), 8(4), 81

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See detailIntegrated prism-free coupled surface plasmon resonance biochemical sensor
Lenaerts, Cedric ULg; Hastanin, Juriy ULg; Pinchemel, Bernard et al

in Proceedings of SPIE (2012), 8424

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See detailImpact of noise correction on diffusion kurtosis estimation
André, Elodie ULg; Balteau, Evelyne ULg; Phillips, Christophe ULg et al

in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society For Magnetic Resonance in Medicine. Scientific Meeting and Exhibition (2012), 20

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See detailChemical control of Haplodiplosis marginata von Roser (Diptera : Cecidomyiidae)
Censier, Florence ULg; Chavalle, Sandrine; Wittouck, Daniel et al

in Communications in Agricultural and Applied Biological Sciences (2012), 78(4), 667-675

The saddle gall midge, Haplodiplosis marginata (von Roser), has been detected in Belgium since 2010, after several decades without any reporting. It had indeed caused serious damages between 1965 and 1970 ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser), has been detected in Belgium since 2010, after several decades without any reporting. It had indeed caused serious damages between 1965 and 1970. This insect is a European cereal pest whose larvae feed on stems and engender saddle-shaped depressions, resulting in yield losses. Face with the resurgence of this pest, it was decided to study its spatial distribution and, because serious damages were observed in some regions, to develop effective curative control. To date, chemical protection seems to be the only immediate solution in case of heavy emergences. Experimentation was conducted in a highly infested field (Meetkerke, Belgian Polders), according to a randomized complete blocks arrangement with four replications. Foremost, a lambdacyhalothrin-based insecticide was used to evaluate efficiency of several protection schemes, ranging between one and four spray(s). The large spread of flights observed during the 2011 spring allowed to highlight the effect of treatment date on the attack intensity and also on the galls distribution along the stem, on the different internodes: the lower internodes were protected by the early sprayings, while last sprayings induced reduction of galls number on the upper internodes. Moreover, several insecticides already registrated in cereals against aphids were compared for their efficacy against saddle gall midge. Studied pyrethroids have shown a very good efficacy, ranging between 75 % and 87 %, when applied twice with a 2 weeks interval. To be efficient, insecticide applications must thus be synchronized with the flights and egg-laying periods. Monitoring the phenology of flights is thus essential as part of integrated pest management against saddle gall midge. [less ▲]

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See detailEffet structuro-modulateur du ranélate de strontium dans la gonarthrose : l'étude SEKOIA
Chevalier, X; Chapurlat, R; Cooper, C et al

in Revue du Rhumatisme (2012), 79(S1), 271

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See detailSpurrite, tilleyite and associated minerals in the exoskarn zone from Cornet Hill (Metalliferi Massif, Apuseni Mountains, Romania).
Marincea, Stefan ULg; Dumitras, Delia; Calin, Nicolas et al

in Geophysical Research Abstracts (2012), 14

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See detailMolecular evolution of the CYTH superfamily of proteins
Bettendorff, Lucien ULg; Delvaux, David ULg; Kohn, Grégory ULg et al

in FEBS Journal (2012), 279(Suppl. s1), 438

Molecular evolution of the CYTH superfamily of proteins L. Bettendorff, D. Delvaux, G. Kohn, P. Wins, B. Lakaye GIGA-Neurosciences, University of Liège, Belgium The CYTH superfamily of proteins was named ... [more ▼]

Molecular evolution of the CYTH superfamily of proteins L. Bettendorff, D. Delvaux, G. Kohn, P. Wins, B. Lakaye GIGA-Neurosciences, University of Liège, Belgium The CYTH superfamily of proteins was named after the two founding members, the CYaB adenylyl cyclase from Aeromonas hydrophila and the human 25-kDa THiamine triphosphatase (ThTPase). Members of this superfamily of proteins exist in all organisms including bacteria, archaea, plants and animals (except in birds) and can be traced back to the Last Universal Common Ancestor. They are characterized by a consensus sequence including several charged residues involved in divalent cation and triphosphate binding. Indeed, all members of the CYTH family that are characterized act on triphosphate derivatives and require at least one divalent cation for catalysis. The Nitrosomonas europaea (1) and E.coli CYTH proteins are specific inorganic triphosphatases. We propose that inorganic triphosphate (PPPi), the most simple triphosphate compound that can be imagined, is the primitive substrate of CYTH proteins. Other enzyme activities such as adenylate cyclase (in A. hydrophila), mRNA triphosphatase (in fungi and protozoans) and ThTPase (in metazoans) activities are secondary acquisitions. We show that ThTPase activity is not limited to mammals, but Sea anemone and Zebrafish CYTH proteins are already specific ThTPases and the acquisition of this enzyme activity is linked to the presence of a Trp (W53 in mammalian ThTPases) residue involved in the binding of the thiazole heterocycle of the thiamine molecule. The importance of W53 for the specificity of mammalian ThTPases is confirmed by site-directed mutagenesis. Furthermore, we propose a conserved catalytic mechanism between inorganic triphosphatases and ThTPases, based on a catalytic dyad comprising a Lys and a Tyr residue, explaining the alkaline pH optimum of CYTH proteins. (1) Delvaux et al. J. Biol. Chem 286 (2011) 34023-35 [less ▲]

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See detailStudy of the factors involved in the aggregation of Harmonia axyridis Pallas (Coleoptera : Coccinellidae)
Durieux, Delphine ULg; Fischer, Christophe ULg; Deneubourg, Jean-Louis et al

in Communications in Agricultural and Applied Biological Sciences (2012), 77(1), 101-104

The aggregative behaviour of the multicoloured Asian ladybeetle, Harmonia axyridis Pallas, during winters, is still misunderstood. Our study was focused on the chemical and physical factors involved in ... [more ▼]

The aggregative behaviour of the multicoloured Asian ladybeetle, Harmonia axyridis Pallas, during winters, is still misunderstood. Our study was focused on the chemical and physical factors involved in the selection of its aggregation sites. Chemical and behavioural analyses highlighted that long-chain hydrocarbons lead congeners towards aggregations and ensure the cohesion of the cluster. On the other hand, we investigated the influence of (1) the density of individuals and (2) the quality of available shelters on H. axyridis decision to settle and aggregate under shelters. A binary choice experiment conducted in laboratory highlighted a permanent aggregative behaviour of H. axyridis, even during non-wintering conditions, and the existence of social interactions between individuals. [less ▲]

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See detailUse of milk fatty acids to substitute for body condition score in breeding purposes
Bastin, Catherine ULg; Berry, D.P.; Soyeurt, Hélène ULg et al

in Journal of Dairy Science (2012), 95, Suppl. 2

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See detailPotentiality of using microbial biosensors for the detection of substrate heterogeneities and the assessment of microbial viability in industrial bioreactors: a complete set of experiments in chemostat and scale-down reactors, and elaboration of a mini scale-down platform
Brognaux, Alison ULg; Neubauer, Peter; Twizere, Jean-Claude ULg et al

in Communications in Agricultural and Applied Biological Sciences (2012), 77(1), 3-7

Substrate limitation responsive biosensors have been used in order to detect spatial substrate heterogeneities, , inside industrial bioreactors (whole-cell biosensor). Three green fluorescent protein (GFP ... [more ▼]

Substrate limitation responsive biosensors have been used in order to detect spatial substrate heterogeneities, , inside industrial bioreactors (whole-cell biosensor). Three green fluorescent protein (GFP) transcriptional reporters have been chosen in E.coli, i.e. uspA::gfp, csiE::gfp and yciG::gfp. The promoter uspA is induced in response to a variety of stresses whereas the two other promoters, csiE and yciG, are supposed to be more specific in front of a substrate limitation. The responsiveness of these biosensors has been assessed in chemostat reactor. Secondly, the same biosensors have been tested in well-mixed laboratory reactors and in scale-down reactors able to reproduce industrial conditions. Finally, a mini scale-down platform has been proposed as a high throughput tool to investigate rapidly the usefulness of a given microbial biosensor. Local heterogeneities in mini-bioreactor have caused a decrease of GFP expression, as in scale-down reactor. The presence of GFP in supernatants was noticed and this leakage seems to be correlated with the membrane permeability. [less ▲]

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See detailCompression test for metal characterization using digital image correlation and inverse modeling
Tuninetti Vásquez, Victor ULg; Gilles, Gaëtan ULg; Péron-Lührs, Vincent ULg et al

in Procedia IUTAM (2012)

In the case of sheet metal characterization, compression tests at normal direction of the sheet can be done by means of the layer compression test. Circular cylinder specimens are commonly used for ... [more ▼]

In the case of sheet metal characterization, compression tests at normal direction of the sheet can be done by means of the layer compression test. Circular cylinder specimens are commonly used for compression test but the complicated layer alignment is time consuming and may induce a wrong anisotropy characterization. This final goal explains the interest of working on elliptic shape. In this article, an elliptical cylinder specimen is proposed and tested for bulk Titanium alloy. Full-field optical technique (3D Digital Image Correlation) is used for displacement measurements by means of three camera systems (Limess), which allows out-of-plane displacement/strain fields on around 300° of the specimen. The use of this technique easily provides accurate barreling profile used to compute Coulomb friction coefficient by using inverse method. [less ▲]

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See detailLe rôle du concept de Tendenz dans l'analyse husserlienne de la fondation à l'époque des Recherches logiques
Gyemant, Maria ULg

in Bulletin d'Analyse Phénoménologique (2012), 8(N°1), 183-201

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See detailDendrochronologie en région bruxelloise et à Spa par l'Université de Liège (CEA) en 2011
Hoffsummer, Patrick ULg; Weitz, Armelle ULg

in Archaeologia Mediaevalis (2012), 35

This is a summary of different dendrochronological analysis of dendro lab in Ulg in cooperation with responsables of Brussels and Walloon heritage during 2011 on vernacular architecture and hisotrical ... [more ▼]

This is a summary of different dendrochronological analysis of dendro lab in Ulg in cooperation with responsables of Brussels and Walloon heritage during 2011 on vernacular architecture and hisotrical monuments [less ▲]

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See detailCorrection of vitamin D insufficiency with the fixed daily combination strontium ranelate 2 g/vitamin D3 1000 IU over 12 months
Rizzoli, R; Dawson-Hughes, B; Kaufman, JM et al

in Arthritis and Rheumatism (2012), 64(S10), 835

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See detailThinking about Ikhtilâf (“Difference”): The Political Construction of Difference in Islamic Context
Nachi, Mohamed ULg

in History of the Present (2012), 2(1/Spring), 52-70

A partir de l'idée d'Ikhtilâf (différence/divergence), fondamentale dans la culture et les sociétés islamiques, cette étude cherche àapporter des réponses nouvelles à la question de la légitimation des ... [more ▼]

A partir de l'idée d'Ikhtilâf (différence/divergence), fondamentale dans la culture et les sociétés islamiques, cette étude cherche àapporter des réponses nouvelles à la question de la légitimation des différences politique, religieuse, culturelle, etc. et, au-delà, de la légitimation du pouvoir et de la souverainté politique dans des sociétés islamiques en mutation. [less ▲]

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See detailMicro and macroscopic investigation to quantify tillage impact on soil hydrodynamic behaviour
Beckers, Eléonore ULg; Roisin, Chrsitian; Plougonven, Erwan ULg et al

in Geophysical Research Abstracts (2012), 14

Nowadays, tillage simplification is an increasing practice. Many advantages are cited in the literature, such as energy saving, soil conservation etc. Agricultural management practices influence soil ... [more ▼]

Nowadays, tillage simplification is an increasing practice. Many advantages are cited in the literature, such as energy saving, soil conservation etc. Agricultural management practices influence soil structure, but consequent changes in soil hydrodynamic behaviour at the field scale are still not well understood. Many studies focus only on macroscopic measurements which do not provide mechanistic explanations. Moreover, research shows divergent conclusions over structure modification. The aim of this work is to fill this gap by quantifying soil structure modification depending on tillage intensity through both macroscopic and microscopic measurements, the latter improving our comprehension of the fundamental mechanisms involved. [less ▲]

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See detailQuel(s) futur(s) pour la Forêt de Soignes ? Adéquation des essences à leurs stations face aux changements climatiques
Claessens, Hugues ULg

in Soignes - Bulletin trimestriel des Amis de la Forêt de Soignes (2012), (n° spécial), 80-85

Het Zoniënwoud straalt ongereptheid uit, heeft een respectabele ouderdom en staat op een moeilijke ondergrond : deze factoren geven de statige beukenkathedraal iets kwetsbaars. Het bos lijdt onder de wind ... [more ▼]

Het Zoniënwoud straalt ongereptheid uit, heeft een respectabele ouderdom en staat op een moeilijke ondergrond : deze factoren geven de statige beukenkathedraal iets kwetsbaars. Het bos lijdt onder de wind en is gevoelig voor hitte en droogte. Het evenwicht met zijn omgeving wordt hierdoor steeds wankeler en de bedreiging door de klimaatverandering gaat zwaarder wegen. Deze objectieve vaststelling kan verschillende reacties uitlokken : keuze voor een veel dynamischere bosbouw naargelang van de verjongingen, geleidelijke verrijking van het bos met soorten die beter gedijen in de toekomstige omstandigheden, zoals de wintereik, of evolutie naar een gemengd en ongelijkvormig hooghout dat beter bestand is tegen verstoring en dat het aanzicht van het Zoniënwoud drastisch zou wijzigen. De liefde voor de beukenkathedraal mag dan wel sterker zijn dan de rede, het is in elk geval nodig de aanplanting van beuken voor een tiental jaar op te schorten, minstens tot er meer zekerheid is over de wetenschappelijke voorspellingen. [less ▲]

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See detailRetrievals of ethane from ground-based high-resolution FTIR solar observations with updated line parameters: determination of the optimum strategy for the Jungfraujoch station.
Bader, Whitney ULg; Perrin, Agnès; Jacquemart, David et al

in Geophysical Research Abstracts (2012), 14(EGU2012-9126),

Ethane (C2H6) is the most abundant Non-Methane HydroCarbon (NMHC) in the Earth’s atmosphere, with a lifetime of approximately 2 months. C2H6 has both anthropogenic and natural emission sources such as ... [more ▼]

Ethane (C2H6) is the most abundant Non-Methane HydroCarbon (NMHC) in the Earth’s atmosphere, with a lifetime of approximately 2 months. C2H6 has both anthropogenic and natural emission sources such as biomass burning, natural gas loss and biofuel consumption. Oxidation by the hydroxyl radical is by far the major C2H6 sink as the seasonally changing OH concentration controls the strong modulation of the ethane abundance throughout the year. Ethane lowers Cl atom concentrations in the lower stratosphere and is a major source of peroxyacetyl nitrate (PAN) and carbon monoxide (by reaction with OH). Involved in the formation of tropospheric ozone and in the destruction of atmospheric methane through changes in OH, C2H6 is a non-direct greenhouse gas with a net-global warming potential (100-yr horizon) of 5.5. The retrieval of ethane from ground-based infrared (IR) spectra is challenging. Indeed, the fitting of the ethane features is complicated by numerous interferences by strong water vapor, ozone and methane absorptions. Moreover, ethane has a complicated spectrum with many interacting vibrational modes and the current state of ethane parameters in HITRAN (e.g. : Rothman et al., 2009, see http://www.hitran.com) was rather unsatisfactory in the 3 µm region. In fact, PQ branches outside the 2973–3001 cm-1 range are not included in HITRAN, and most P and R structures are missing. New ethane absorption cross sections recorded at the Molecular Spectroscopy Facility of the Rutherford Appleton Laboratory (Harrison et al., 2010) are used in our retrievals. They were calibrated in intensity by using reference low-resolution spectra from the Pacific Northwest National Laboratory (PNNL) IR database. Pseudoline parameters fitted to these ethane spectra have been combined with HITRAN 2004 line parameters (including all the 2006 updates) for all other species encompassed in the selected microwindows. Also, the improvement brought by the update of the line positions and intensities of methyl chloride (CH3Cl) in the 3.4 m region (Bray et al., 2011) will be quantified. The ethane a priori volume mixing ratio (VMR) profile and associated covariance are based on synthetic data from the chemical transport model (CTM) of the University of Oslo. In this contribution, we will present updated ethane total and tropospheric column retrievals, using the SFIT-2 algorithm (v3.91) and high-resolution Fourier Transform Infrared (FTIR) solar absorption observations recorded with a Bruker 120HR instrument, at the high altitude research station of the Jungfraujoch (46.5°N, 8°E, 3580 m asl), within the framework of the Network for the Detection of Atmospheric Composition Change (NDACC, visit http://www.ndacc.org). We will characterize three microwindows encompassing the strongest ethane features after careful selection of a priori VMR profiles, spectroscopic parameters, accounting at best for all interfering species. We will then present the retrieval strategy representative of the best combination of those three characterized micro-windows in order to minimize the fitting residuals while maximizing the information content, the precision and the reliability of the retrieved product. The long-term C2H6 column time series will be produced using the Jungfraujoch observational database. Comparisons with synthetic data produced by two chemical transport model (CHASER and the one of the University of Oslo) will also be presented and analyzed, aiming at the determination and interpretation of long-term trends and interannual variations of ethane at Northern mid-latitudes. [less ▲]

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See detailThe Casimir Effect and the Vacuum Energy: Duality in the Physical Interpretation
Cugnon, Joseph ULg

in Few-Body Systems (2012), 53(1-2), 181-188

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See detailHow could Mosan agriculture be impacted by climate change and future droughts?
Bauwens, Alexandra ULg; Sohier, Catherine ULg; Deraedt, Deborah ULg et al

in Geophysical Research Abstracts (2012), 14

Despite the great uncertainties regarding the future climatic context, lots of studies have focused on hydrological effects of climate change on the Meuse catchment. It appears that both winter high flows ... [more ▼]

Despite the great uncertainties regarding the future climatic context, lots of studies have focused on hydrological effects of climate change on the Meuse catchment. It appears that both winter high flows and summer low flows could be exacerbated. Climate change and its impacts on hydrology will thus affect various socio-economic sectors. High flows have been widely studied compared to low-flows. This poster will put the emphasis on a methodology developed in order to study impacts of droughts on agriculture. Agriculture is among the most impacted sectors due to climate change. The consequences could be both positive as negative in accordance with the range of predicted changes and the adaptation capacity of agricultural systems. Most of the existing studies related to climate change on agriculture focused on specific territory. Within the AMICE Interreg IVB project, a transnational approach has been developed to assess droughts impacts on agriculture through the Meuse basin. The project’s previous works gave us a common scenario of climate trends and of the evolution of the hydrology in the Meuse basin. The methodology is based on the use of a physically-based model able to simulate the water-soil-plant continuum (derived from EPIC model). In order to be transferable from one country to another, the methodology proposed used data available at the basin scale. The UE soil data base was complemented with local information on agricultural practices and statistics. Three crops have been studied: maize, wheat and barley. The basic cultural calendar is supposed to be the same for the different countries. The methodology developed permits to study the evolution of yields, leaf area index, crops stress due to excess or lack of water through time under different scenarios build up in the frame of the project. It appears that corn is negatively affected by climate change, and thus despite the CO2 fertilization effect. Wheat and barley have similar behavior and are positively affected by climate change and CO2 fertilization. Leaf Area Index study reveals that the different crops start earlier and reach earlier maturity. These first results will be completed with other economic sectors’analysis like drinkable water production, electricity production and navigation. Therefore, the project will progress towards a better understanding of economic effects of future droughts and low-flows. [less ▲]

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See detailEffect of a fungal infection on the profile of volatile organic compounds emitted by plant roots
Fiers, Marie ULg; Lognay, Georges ULg; Wathelet, Jean-Paul ULg et al

in Communications in Agricultural and Applied Biological Sciences (2012), 77(3), 125-129

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See detailModelling of agricultural diffuse pollution and mitigation measures effectiveness inWallonia (Belgium)
Sohier, Catherine ULg; Deraedt, Deborah ULg; Degré, Aurore ULg

in Geophysical Research Abstracts (2012), 14(EGU2012), 9672

Implementation of European directives in the environmental field and, specially, in the water management field, generates a request from policy-makers for news tools able to evaluate impact of management ... [more ▼]

Implementation of European directives in the environmental field and, specially, in the water management field, generates a request from policy-makers for news tools able to evaluate impact of management measures aiming at reducing pressures on ecosystems. In Wallonia (Southern Region of Belgium), the Nitrate Directive (EEC/676/91) was transposed into the “Walloon action plan for nitrogen sustainable management in agriculture” (PGDA1) in 2002. In 2007, a second plan was launched to reinforce some topics (PGDA2). Furthermore, the goal of “good quality” of surface waters and groundwater imposed by the Water Framework Directive poses new challenges in water management. In this context, a “soil and vadose” hydrological model is used in order to evaluate diffuse pollutions and efficiency of mitigation measures. This model, called EPICgrid, has been developed at catchment scale with an original modular concept on the basis of the field scale “water-soil-plant” EPIC model (Williams J.R., Jones C.A., Dyke P.T. (1984). A modelling approach to determining the relationship between erosion and soil productivity. Transactions of the ASAE. 27, 129-144). The model estimates, for each HRU identified into a 1km2 grid, water and nutrients flows into the plant-soil-vadose zone system (Sohier C., Degré A., Dautrebande S. (2009). From root zone modelling to regional forecasting of nitrate concentration in recharge flows – The case of the Walloon Region (Belgium). Journal of Hydrology, Volume 369, Issues 3-4, 15 May 2009, Pages 350-359). The model is used to make prospective simulations in order to evaluate the impact of measures currently performed to reduce the effect of diffuse pollution on water surface quality and groundwater quality, at regional scale. Response of the soil-vadose zone to agricultural practices modification is analyzed for the deadlines of the Water Framework Directive: 2015, 2021 and 2027, taking into account two climatic scenarios. Simulations results showed that actual measures are not sufficient in some areas and that new actions are necessary. The EPICgrid model was also used to evaluate effectiveness of further measures that could be implemented in order to reduce agricultural diffuse pollution. The increasing of catch crops in vulnerable zones has shown a limited impact in theWalloon context. The modifications of agricultural practices such as crop rotations or mineral fertilizing amounts have shown a more significant impact on water quality. Furthermore, the farmers’ practices are evaluated each year by a measuring campaign of the soil nitrogen residue after harvest. These data allow us to improve the representativeness of the EPICgrid model in areas in which agricultural practices largely differs from regional statistics. [less ▲]

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See detailAssociation entre l'hypertrophie du chondrocyte et l'angiogenèse du cartilage dans l'arthrose
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Delcour, Jean-Pierre et al

in Revue du Rhumatisme (2012), 79(S), 105-106

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