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See detailWhat is the value of biomarkers for drug development in osteoarthritis?
Lotz, Martin; Martel-Pelletier, Johanne; Christiansen, Claus et al

in Osteoporosis International (2013, April), 24(Suppl.1), 77-78

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See detailSuperior Renal Function Sustained for 24 Months through Early Everolimus-Facilitated Reduction of Tacrolimus Versus Standard Tacrolimus in De Novo Liver Transplant Recipients: Results of a Randomized Trial.
De Simone, Pierre; DETRY, Olivier ULg; Kintmalm, G et al

in American Journal of Transplantation (2013, April), 13(S5), 169450

mTOR inhibitors have the potential to reduce calcineurin inhibitor nephrotoxicity by minimizing or eliminating the need for their use. The 12 month (M) results of H2304 (NCT00622869) study demonstrated ... [more ▼]

mTOR inhibitors have the potential to reduce calcineurin inhibitor nephrotoxicity by minimizing or eliminating the need for their use. The 12 month (M) results of H2304 (NCT00622869) study demonstrated superior renal function with everolimus (EVR) plus reduced tacrolimus (rTAC) vs. standard TAC (TAC-C) in de novo liver transplant recipients (LTxR). Presented here are 24M renal function results. For this 24M, multicenter, open-label study 719 de novo LTxR were randomized (1:1:1) after a 30-day (±5 days) run-in period with TAC (±mycophenolate mofetil), to receive either EVR (C0 3-8 ng/mL) with rTAC (C0 3-5 ng/mL; EVR+rTAC, N=245) or EVR (C0 6-10 ng/mL) with TAC withdrawal (TAC-WD; N=231) at M4 or TAC-C (C0 6-10 ng/mL; TAC-C, N=243); all patients received corticosteroids. Enrollment in TAC-WD arm was stopped early due to higher rejection rates. Main endpoints at M24 included composite ef􏰀cacy failure rate of treated biopsy proven acute rejection, graft loss or death, and evolution of renal function from randomization (RND) to M24 measured as eGFR by MDRD4. At M24, composite ef􏰀cacy failure rate in EVR+rTAC arm was comparable to TAC-C (10.3% vs. 12.5%, p=0.452). Evolution of renal function from RND to M24 was superior for EVR+rTAC vs. TAC-C with an adjusted mean difference in eGFR change of 6.66 mL/min/1.73m2 (p=0.0018; ITT population). Signi􏰀cantly higher eGFR with EVR+rTAC was achieved at M2 post-LTx and was maintained until M24. On-treatment data showed a decrease in mean eGFR from RND to M24 of 6.6 mL/min/1.73m2 with EVR+rTAC vs. 13 mL/min/1.73m2 with TAC-C and 2.5 mL/ min/1.73m2 gain with TAC-WD. Urinary protein:creatinine ratio (mg/g) at M24 was higher with EVR+rTAC vs. TAC-C (Mean±SD: 194±280 vs. 159±284, p=0.006). Early introduction of EVR at 1M post-LTx with rTAC showed superior renal function sustained for 24M compared to TAC-C, without compromising ef􏰀cacy in de novo LTxR. [less ▲]

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See detailWhat is the predictive value of MRI for the occurrence of hard clinical endpoints in knee osteoarthritis?
Pelletier, Jean-Pierre; Peterfy, Charles; Brandi, Maria Luisa et al

in Osteoporosis International (2013, April), 24(Suppl.1), 84-85

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See detailQuality of life in sarcopenia and frailty
Rizzoli, René; Reginster, Jean-Yves ULg; Arnal, Jean-François et al

in Osteoporosis International (2013, April), 24(Suppl.1), 76-77

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See detailEvaluation of the impact of a 6-month training by whole body vibration on the risk of falls among nursing home residents
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Demonceau, Marie ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 246-247

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See detailOARSI recommended performance-based tests to assess physical function in people with established hip and knee osteoarthritis
Dobson, F.; Hinman, R.S.; Roos, E.M. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

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See detailQuantitative gait assessment using an accelerometer technology as a predictive tool of falls among nursing home residents: a 6-month prospective study
Bruyère, Olivier ULg; Detalle, Anne-Sophie; Demonceau, Marie ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 210

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See detailRole of nutraceuticals in the symptomatic and structural management of osteoarthritis
Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 82-83

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See detailEffects of chondroitin sulfate on the gene expression profile in the inflamed synovial membrane
Lambert, Cécile ULg; Dubuc, J-E; Montell, E. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a ... [more ▼]

Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a second step, we investigated the genetic modulatory effects of chondroitin sulfate (CS) in this model. Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days in the absence or in the presence of highly purified bovine CS (200 µg/ml, Bioibérica S.A., Barcelona, Spain). Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I conditions, N/R and N/R-CS conditions and I and I-CS conditions was based on paired t-test where N/R and I, N/R and N/R-CS and I and I-CS were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Results: From among 47000 probes, 18253 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 465 differentially expressed genes between N/R and I areas were identified. Many inflammatory mediators appear differentially expressed. The interferon alpha-inductible protein 6 (IFI6) was the most up-regulated. We also identified the hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), the cathepsin K (CTSK), the chemokine (C-X-C motif) ligand 1 (CXCL1) and the EBV-induced G-protein coupled receptor 2 (EBI2). The differential expression of intermediates involved in angiogenesis pathway was also revealed between N/R and I areas. Among them, R-spondin-3 (RSPO3), the secreted phopshoprotein 1 (SPP1) and aquaporin 9 (AQP9) were up-regulated whereas ADAMTS1 was down-regulated. Finally, in the Wnt signaling, RSPO3 was up-regulated unlike dickkopf homolog 3 (DKK3) which was in turn down-regulated. We next performed a class comparison test between N/R and N/R-CS in one hand and between I and I-CS the other hand. 489 genes were identified as differentially expressed genes between N/R and N/R-CS conditions while 219 genes were identified between I and I-CS conditions. In this latter, our attention was focused on the down-regulated genes. Among them, we identified a number implicated in angiogenesis and cell migration pathways. Thus, the endothelial cell-specific molecule-1 (ESM1), the Transmembrane-4-L-six-family-1 (TM4SF1), the 5’-Ectonucleotidase (NT5E) and the growth arrest-specific gene 6 (GAS6) were down-regulated by CS. Conclusions: Our work demonstrates the differential gene expression profile between paired non inflammatory and normal/reactive areas of synovial membrane as well as the modulatory effects of CS on gene expression in the inflammatory areas, especially regarding genes involved in both angiogenesis and cell migration. [less ▲]

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See detailPlanet TOPERS: Planets, Tracing the Transfer, Origin, Preservation, and Evolution of Their Reservoirs
Dehant, V.; Van Hoolst, T.; Breuer, D. et al

in Geophysical Research Abstracts (2013, April), 15

An overview is given of the Planet TOPERS project addressing habitability in our solar system.

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See detailEffects of chondroitin sulfate on the gene expression profile in IL-1β stimulated synovial fibroblast cells cultures
Lambert, Cécile ULg; Dubuc, Jean-Emile; Montell, E. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. In this study, we performed a microarray analysis and identified a differential expression profile between control ... [more ▼]

Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. In this study, we performed a microarray analysis and identified a differential expression profile between control and IL-1β stimulated synovial fibroblast cells cultures. In a second step, we investigated the effects of CS on this gene expression profile. Methods: OA synovial specimens were obtained from 12 patients undergoing knee replacement. At the surgery time, the synovial membrane was dissected. Synovial fibroblast cells (SFC) were enzymatically isolated and used after four passages (P4). SFC were pre-treated 1 hour with highly purified bovine CS (200 µg/ml, Bioibérica S.A., Barcelona, Spain) before treatment with IL-1β (1 ng/ml) for 24 hours. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class comparison test between control (Ctl) and interleukin (IL)-1β conditions, Ctl and Ctl/CS and IL-1β and IL-1β/CS conditions was based on paired t-test where Ctl and IL-1β, Ctl and Ctl/CS and IL-1β and IL-1β/CS were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Probes with a p-value below 0.001 were chosen and classified as up- or down-regulated ones. Results: 3308 genes were identified as differentially expressed genes between Ctl and IL-1β conditions. We observed a differential profile of expression of major pathways involved in OA pathogenesis. The key identified pathways were related to inflammation, complement cascade, angiogenesis, cartilage catabolism and anabolism and Wnt signaling. In the inflammatory network, the most upregulated cytokines were IL-8 and IL-6 with a fold change of 156.25 and 58.8 respectively. We also identified several chemokines, enzymes and metallothioneins (MTs). Complement factor B (CFB) and complement component 3 (C3) are two factors upregulated in the inflammatory complement cascade. We also identified some genes implicated in the angiogenesis pathway. The most upregulated was Stanniocalcin 1 (STC1) with a fold change of 9.09. The differential expression of intermediates involved in both cartilage anabolism and catabolism was revealed by the IL-1β stimulation, showing an imbalance in favour of catabolism. MMP-3 was largely upregulated (fold change of 62.5). Wnt 5A and low density lipoprotein receptor-related protein (LRP8) were significantly upregulated while frizzled homolog 2 (FZD2) and dickkopf homolog 3 (DKK3) were downregulated in the Wnt signaling pathway. We next performed a class comparison test between Ctl and Ctl/CS in one hand and IL-1β and IL-1β/CS on the other hand. 660 genes were identified as differentially expressed between Ctl and Ctl/CS conditions while 241 genes were identified between IL-1β and IL-1β/CS. Among them, our attention was focused on two genes upregulated in the presence of CS: lysyl oxidase-like 4 (LOXL4) and claudin 11 (CDLN11), two genes that negatively regulate cell invasion. Conclusions: We here evidenced in synovial fibroblast cells the modulation of gene expression following IL-1β stimulation. We also demonstrated the modulatory effects of CS on gene expression and isolated several CS-modulated genes of interest such as LOXL4 and CDLN11, which could constitute new mechanisms of action of the molecule and contribute to explain the symptomatic efficacy of CS in the treatment of OA. [less ▲]

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See detailStrontium ranelate improves osteoarthritis symptoms compared to placebo in patients with knee OA: The SEKOIA study
Bruyère, Olivier ULg; Richette, P; Bellamy, N et al

in Osteoporosis International (2013, April), 24(Suppl.1), 49-51

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See detailValidity of the French hip and knee replacement expectations surveys
NEUPREZ, Audrey ULg; François, Garance ULg; Delcour, JP et al

in Osteoporosis International (2013, April), 24(Suppl.1), 374

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See detailNonpharmacological management
Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 76

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of postmenopausal women
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Rabenda, Véronique ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 198

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See detailMise en oeuvre du Programme de Gestion Durable de l'Azote à l'échelle de deux petits bassins versants (Arquennes - Belgique) et évaluation d'impact par le suivi des flux de nitrate aux exutoires et par modélisation numérique
Deneufbourg, Mathieu ULg; Vandenberghe, Christophe ULg; Gaule, David et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013, April), 17(S1), 164-176

Four water catchments used by the Walloon Society of Water (SWDE) in the rural village of Arquennes (Province of Hainaut, Belgium) have been contaminated by nitrate (concentrations between 60 and 70 mg ... [more ▼]

Four water catchments used by the Walloon Society of Water (SWDE) in the rural village of Arquennes (Province of Hainaut, Belgium) have been contaminated by nitrate (concentrations between 60 and 70 mg NO3-·l-1) for several years. The catchment basins (31 ha and 47 ha) are located exclusively in a cultivated area on loamy soils. Since October 2004, these basins have been used as a pilot area for the environmental evaluation of good agricultural practices as regards nitrogen management (adaptation of amounts of mineral nitrogen fertilizers, farm manure management, soil cover after harvest, etc.) thanks to monitoring by farmers. This approach fits into the general pattern of the Sustainable Nitrogen Management Program (PGDA in French), which implements the European Nitrates Directive as part of Walloon legislation. The second objective of the working scheme is to study and to set up a decision-making tool aimed at preventing the contamination of water by agricultural nitrate around water catchments. Two numerical models (SWAT and FEFLOW®) were used together in order to simulate the passage of water and nitrogen from the soil surface to the water catchments outlets. Calibration and validation of models were based, among other things, on soil and subsoil characterization and on tracer testing in both saturated and unsaturated zones. Moreover crop yield, farming practices, water and nitrate fluxes in water catchments, groundwater levels and nitrate concentration in groundwater were monitored for eight years. The results of simulations show that the application of PGDA in Arquennes watersheds would lead to a decrease in nitrate concentration (to almost 50 mg NO3-·l-1) in water catchments in 2012. This expected improvement in water quality has been visible since 2009 in water catchments, with mean nitrate concentrations of lower than 50 mg NO3-·l-1 at the end of 2012. [less ▲]

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See detailReproducibility of joint space width assessment when external calibration on the radiograph is missing
DEROISY, Rita ULg; Reginster, Jean-Yves ULg; Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 379

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See detailScalar triplet leptogenesis without right-handed neutrino decoupling
Aristizabal Sierra, Diego ULg

in Nuclear Physics B Proceedings Supplement (2013, April), 237-238

We discuss leptogenesis in the context of type-II seesaw in the case in which in addition to the scalar electroweak triplet decays the lepton asymmetry is also induced by right-handed neutrino decays ... [more ▼]

We discuss leptogenesis in the context of type-II seesaw in the case in which in addition to the scalar electroweak triplet decays the lepton asymmetry is also induced by right-handed neutrino decays (mild hierarchical scenarios). We show that within this setup, depending on the relative sizes of the relevant parameters, one can identify three classes of generic models, each one with its own consequences for leptogenesis. [less ▲]

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See detailHealth economics in osteoarthritis
Hiligsmann, Mickaël ULg; Cooper, Cyrus; Arden, Nigel et al

in Osteoporosis International (2013, April), 24(Suppl.1), 79-80

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See detailOrthanc - A lightweight, RESTful DICOM server for healthcare and medical research
JODOGNE, Sébastien ULg; Bernard, Claire ULg; DEVILLERS, Magali ULg et al

in Proceedings, IEEE International Symposium on Biomedical Imaging: from Nano to Macro (2013, April)

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See detailClinical characteristics of patients responsive to whole body vibration
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Maquet, Didier ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 243

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See detailThe intra-articular injection of a new chitosan biomaterial prevents the progression of osteoarthritis in ACLT rabbit model
Oprenyeszk, Frédéric ULg; Chausson, Mickael; Maquet, Véronique et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), 69

Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on ... [more ▼]

Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on cartilage lesion in osteoarthritis (OA) rabbit model. These effects were compared to those obtained with the intra-articular injection of either chitosan-based (H) hydrogel without the AC bead or saline solution. Methods OA was surgically induced by the transection of the anterior cruciate ligament (ACLT) in HYLA albino rabbits. One week after surgery, animals were randomly divided into 3 groups: group I (n=7): mix of AC beads and H hydrogel; group II (n=7): H hydrogel alone; group III (n=7): saline solution (control). The treatments (900 µl) were injected intra-articularly. X-rays from the right knee were performed before surgery, at the time of injection and at sacrifice. The standard radiographs were acquired in extension and scored by the Kellgren and Lawrence (K&L) scale. After 6 weeks, animals were euthanized and the right joint was dissected. The macroscopic evaluation of cartilage from femoral condyles and tibial plateaus stained with India ink was done. Histological sections stained with Safranine-O/fast green from bearing areas of each compartment were evaluated according to the OARSI histological score. Briefly, the evaluation considered: staining of the cartilage matrix (0-6), cartilage structure (0-11), chondrocyte density (0-4) and cluster formation (0-3), where 0 represented a normal situation and 24 points the maximum severity score. Blood samples were collected the day of injection and prior the sacrifice. Prostaglandin E2 (PGE2) and C-reactive protein (CRP) were measured in serum using immunoassays. Results The X-rays analysis showed a significant decrease (p <0.05) of the K&L score in group I (AC beads and H hydrogel; 1.5 ± 0.2) compared with group II (H hydrogel; 2.2 ± 0.5) and group III (saline solution; 3.0 ± 0.4). The size and the severity of the macroscopic OA cartilage lesion tended to decrease in group I compared to the other groups. The histological global score that refers to all compartments of the knee joint was significantly decreased in group I (11.0 ± 0.7) compared to group II (14.4 ± 0.6, p <0.01) and group III (14.8 ± 0.6, p <0.001). No significant variation of PGE2 and CRP serum levels were observed in each after 6 weeks follow-up whatever the treatment injected. Conclusions This study showed that a biphasic hydrogel composed by AC beads and H hydrogel prevented OA in rabbit with ACL transection. This effect was not observed with the hydrogel alone, suggesting that AC beads play a role in joint protection. The preventive effect was observed in all joint compartments indicating a global protective effect of this new viscosupplementation. [less ▲]

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See detailChanges in the structure and the symptoms of the osteoarthritis knee and prediction of future knee replacement over an 8-year follow-up period
Bruyère, Olivier ULg; Cooper, Cyrus; Pavelka, Karel et al

in Osteoporosis International (2013, April), 24(Suppl.1), 209

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See detailMode lifetime and associated scaling relations
Belkacem, K.; Appourchaux, T.; Baudin, F. et al

in EPJ Web of Conferences (2013, March 01), 43

Thanks to the CoRoT and Kepler spacecrafts, scaling relations (linking seismic indices and global stellar parameters) are becoming the cornerstone of ensemble asteroseismology. Among them, the relation ... [more ▼]

Thanks to the CoRoT and Kepler spacecrafts, scaling relations (linking seismic indices and global stellar parameters) are becoming the cornerstone of ensemble asteroseismology. Among them, the relation between the cut-off frequency and the frequency of the maximum in the power spectrum of solar-like pulsators as well as the relation between mode lifetime and the effective temperature remain poorly understood. However, a solid theoretical background is essential to assess the accuracy of those relations and subsequently of the derived stellar parameters. We will thus present recent advances on the understanding of the underlying mechanisms governing those relations and show that the physics of mode lifetime (thus of mode damping) plays a major role. [less ▲]

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See detailAmplitudes of solar-like oscillations in red giants: Departures from the quasi-adiabatic approximation
Samadi, R.; Belkacem, K.; Dupret, Marc-Antoine ULg et al

in European Physical Journal Web of Conferences (2013, March 01), 43

CoRoT and Kepler measurements reveal us that the amplitudes of solar-like oscillations detected in red giant stars scale from stars to stars in a characteristic way. This observed scaling relation is not ... [more ▼]

CoRoT and Kepler measurements reveal us that the amplitudes of solar-like oscillations detected in red giant stars scale from stars to stars in a characteristic way. This observed scaling relation is not yet fully understood but constitutes potentially a powerful diagnostic about mode physics. Quasi-adiabatic theoretical scaling relations in terms of mode amplitudes result in systematic and large differences with the measurements performed for red giant stars. The use of a non-adiabatic intensity-velocity relation derived from a non-adiabatic pulsation code significantly reduces the discrepancy with the CoRoT measurements. The origin of the remaining difference is still unknown. Departure from adiabatic eigenfunction is a very likely explanation that is investigated in the present work using a 3D hydrodynamical model of the surface layers of a representative red giant star. [less ▲]

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See detailRed giants rotational splittings
Ouazzani, R. M.; Goupil, M. J.; Dupret, Marc-Antoine ULg et al

in EPJ Web of Conferences (2013, March 01), 43

The space missions CoRoT and Kepler provide high quality data that allow to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. Our aim is to ... [more ▼]

The space missions CoRoT and Kepler provide high quality data that allow to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. Our aim is to test the validity of the seismic diagnostics for red giant rotation that are based on a perturbative method and to investigate the oscillation spectra when the validity does not hold. We use a non-perturbative approach implemented in the ACOR code [1] that accounts for the effect of rotation on pulsations, and solves the pulsations eigenproblem directly for dipolar oscillation modes. We find that the limit of the perturbation to first order can be expressed in terms of the core rotation and the period separation between consecutive dipolar modes. Above this limit, each family of modes with different azimuthal symmetry m, has to be considered separately. For rapidly rotating red giants, new seismic diagnostics can be found for rotation by exploiting the differences between the period spacings associated with each m-family of modes. [less ▲]

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See detailNon-radial, non-adiabatic solar-like oscillations in RGB and HB stars
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, K. et al

in EPJ Web of Conferences (2013, March 01), 43

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in ... [more ▼]

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in the same region of the HR diagram but in different evolutionary phases. We present here our first results on the inertia, lifetimes and amplitudes of the oscillations and discuss the differences between the two stars. [less ▲]

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See detailStockage de bois chablis sous bâche
Castaings, Frédéric; Jourez, Benoît ULg; Riguelle, Simon ULg

in Infos de RND (Les) (2013, March), (1er semestre), 3-5

Le samedi 24 janvier 2009, la tempête Klaus traverse le sud-ouest de la France. Tempête la plus dévastatrice depuis 1999, la forêt des Landes et ses pins maritimes paient un lourd tribut à ce phénomène ... [more ▼]

Le samedi 24 janvier 2009, la tempête Klaus traverse le sud-ouest de la France. Tempête la plus dévastatrice depuis 1999, la forêt des Landes et ses pins maritimes paient un lourd tribut à ce phénomène extrême: 60% de la superficie est touchée, environ 40 millions de m3 de bois sont à terre, quatre fois la récolte annuelle. Il faudra attendre plusieurs mois avant que les aires de stockage par aspersion soient opérationnelles. Trop tard, le pin maritime montre déjà des signes de bleuissement de son bois, il est invendable sur les marchés à forte valeur ajoutée, là où l’esthétisme prime. Écarté des meilleurs débouchés, le lambris et le plancher, le manque à gagner est énorme. Un tel scénario catastrophe, notre région s’y prépare depuis 2005, tirant les enseignements des expériences étrangères et fondant son action sur les spécificités de notre forêt, de notre filière. C’est dans ce cadre que le 28 février dernier, à Eupen, des grumes d’épicéa stockées depuis presque cinq ans ont été extraites des bâches hermétiques qui les protégeaient. Comment le bois est-il ressorti de cette épreuve? Que penser de cette méthode alternative de stockage? Quelle place lui réserver ? Benoit Jourez du Laboratoire de Technologie du Bois du DEMNA (Département de l’Étude du milieu naturel et agricole) nous a apporté son éclairage et nous a conviés à l’ouverture de la poche étanche. Entre supputations et réalité des bois extraits après cinq ans, suspense… [less ▲]

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See detailAn overview of white dwarf stars
Fontaine, Gilles; Brassard, Pierre; Charpinet, Stéphane et al

in EPJ Web of Conferences (2013, March), 43

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of ... [more ▼]

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of stellar evolution for the vast majority of stars and, as such, bear the signatures of past events (such as mass loss, mixing phases, loss and redistribution of angular momentum, and thermonuclear burning) that are of essential importance in the evolution of stars in general. In addition, white dwarf stars represent ideal testbeds for our understanding of matter under extreme conditions, and work on their constitutive physics (neutrino production rates, conductive and radiative opacities, interior liquid/solid equations of state, partially ionized and partially degenerate envelope equations of state, diffusion coefficients, line broadening mechanisms) is still being actively pursued. Given a set of constitutive physics, cooling white dwarfs can be used advantageously as cosmochronometers. Moreover, the field has been blessed by the existence of four distinct families of pulsating white dwarfs, each mapping a different evolutionary phase, and this allows the application of the asteroseismological method to probe and test their internal structure and evolutionary state. We set the stage for the reviews that follow on cooling white dwarfs as cosmochronometers and physics laboratories, as well as on the properties of pulsating white dwarfs and the asteroseismological results that can be inferred. [less ▲]

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See detailBelgian multicentre experience with intestinal transplantation
Ceulemans, L; DE ROOVER, Arnaud ULg; DETRY, Olivier ULg et al

in Acta Gastro-Enterologica Belgica (2013, March), 76(1), 07

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See detailThe empirical mass distribution of hot B subdwarfs: implications for stellar evolution theory
Van Grootel, Valérie ULg; Fontaine, Gilles; Charpinet, Stéphane et al

in EPJ Web of Conferences (2013, March), 43

Subdwarf B (sdB) stars are hot, compact, and evolved objects that form the very hot end of the horizontal branch, the so-called Extreme Horizontal Branch (EHB). Understanding the formation of sdB stars is ... [more ▼]

Subdwarf B (sdB) stars are hot, compact, and evolved objects that form the very hot end of the horizontal branch, the so-called Extreme Horizontal Branch (EHB). Understanding the formation of sdB stars is one of the remaining challenges of stellar evo- lution theory. Several scenarios have been proposed to account for the existence of such objects, made of He-burning core surrounded by very thin H-rich envelope. They give quite different theoretical mass distributions for the resulting sdB stars. Detailed astero- seismic analyses, including mass estimates, of 15 pulsating hot B subdwarfs have been published since a decade. The masses have also been reliably determined by light curve modeling and spectroscopy for 7 sdB components of eclipsing and/or reflection effect binaries. These empirical mass distributions, although based on small-number statistics, can be compared with the expectations of stellar evolution theory. In particular, the two He white dwarfs merger scenario does not seem to be the dominant channel to form iso- lated sdB stars, while the post-red giant branch scenario is reinforced. This opens new questions on extreme mass loss of red giants to form EHB stars, possibly in connection with the recently discovered close substellar companions and planets orbiting sdB stars. [less ▲]

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See detailAsteroseismology of hot B subdwarf stars
Charpinet, Stéphane; Van Grootel, Valérie ULg; Brassard, Pierre et al

in EPJ Web of Conferences (2013, March), 43

Nonradial pulsations in Extreme Horizontal Branch stars (also known as hot B subdwarfs or sdB stars) offer strong opportunities to study through asteroseismology the structure and internal dynamics of ... [more ▼]

Nonradial pulsations in Extreme Horizontal Branch stars (also known as hot B subdwarfs or sdB stars) offer strong opportunities to study through asteroseismology the structure and internal dynamics of stars in this intermediate stage of stellar evolution. Most sdB stars directly descend from former red giants and are expected to evolve straight into white dwarfs after core helium exhaustion. They thus represent the most direct link between these two stages. Their properties should therefore reflect both the outcome of the core evolution of red giant stars and the initial state for a fraction of the white dwarfs. We review the status of this field after a decade of efforts to exploit both p-mode and g-mode pulsating sdB stars as asteroseismic laboratories. From the discoveries of these two classes of pulsators in 1997 and 2003, respectively, up to the current epoch of data gathering of unprecedented quality from space, a lot of progress has been made in this area and prospects for future achievements look very promising. [less ▲]

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See detailDifférences d’activité de l’inflammasome NLRP3 entre sujets obèses avec et sans anomalies métaboliques
Esser, Nathalie ULg; L'Homme, Laurent ULg; DE ROOVER, Arnaud ULg et al

in Diabètes & Métabolism (2013, March), 39(suppl 1), 102

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See detailDevelopment of an experimental device allowing plant-plant interaction studies and in situ dynamic trapping of volatile organic compounds emitted by barley (Hordeum distichon L.) roots
Delory, Benjamin ULg; Delaplace, Pierre ULg; Fauconnier, Marie-Laure ULg et al

in Communications in Agricultural and Applied Biological Sciences (2013, February 08), 78(1), 97-102

In response to wounding or herbivore attack, leaves and roots of higher plants release volatile organic compounds (VOCs). To date, VOCs analysis and plant−plant interaction studies have been mainly ... [more ▼]

In response to wounding or herbivore attack, leaves and roots of higher plants release volatile organic compounds (VOCs). To date, VOCs analysis and plant−plant interaction studies have been mainly performed on aboveground plant tissues, leaving the roles played by root VOCs in plant−plant interaction unexplored. In this context, this project aims at setting up an original experimental device allowing both dynamic trapping of VOCs emitted by mechanically damaged H. distichon roots and the study of the roles played by root VOCs in intra and interspecific plant−plant interactions. The experimental device consists of Barley seedlings cultivated in closed PTFE reactors filled with wet sand. Before being analysed by gas chromatography−mass spectrometry, root VOCs are trapped via a dynamic system on Tenax cartridges using a charcoal-filtered and humidified air. Preliminary results show that 7 day-old wounded Barley roots emit C9 fatty acid derivatives (E-non-2-enal and nona-2,6-dienal) as major compounds, contrasting with aboveground plant tissues that mainly emit C6 alcohols, aldehydes, and their derivative esters. For plant−plant interaction studies, receiver plants are exposed to an airflow enriched with VOCs from root damaged Barley plants of the same age. [less ▲]

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See detailLong term measurements of volatile organic compounds exchanges above a maize field at Lonzee (Belgium)
Bachy, Aurélie ULg; Aubinet, Marc ULg; SALERNO, Giovanni ULg et al

in Communications in Agricultural and Applied Biological Sciences (2013, February), 78(1), 127-132

VOC (volatile organic compounds) include a wide set of molecules which are mostly emitted by the plants. Atmospheric scientists are strongly interested in these compounds because of their important role ... [more ▼]

VOC (volatile organic compounds) include a wide set of molecules which are mostly emitted by the plants. Atmospheric scientists are strongly interested in these compounds because of their important role in the atmospheric chemistry and their final impact on air pollution and climate change. Evaluation of current and future VOC emissions is thus necessary and requires a comprehensive understanding of VOC production and exchange dynamics under a wide panel of climatic conditions and ecosystems. Forest and non pastured grasslands have been largely studied for the last decade. However, knowledge about VOC fluxes from croplands remains scarce. Our study focuses on the VOC exchanges between a maize field and the atmosphere. It is incorporated in a wider project that aims to study VOC fluxes from two croplands (maize and winter wheat) and a pastured grassland. VOC fluxes have been measured on a maize field during the whole growing season using a micrometeorological method (eddy covariance). While first results show half-hourly bidirectionnal exchanges among all the preselected compounds, in average methanol stands for the greatest emitted VOC, followed by green leaf volatiles, and acetic acid is the greatest taken up VOC. Small isoprene and monoterpenes fluxes are also observed. A diurnal pattern is found for all those VOC, with greater emission/uptake during the day, suggesting a flux dependence on environmental parameters. These environmental controls will be further investigated [less ▲]

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See detailLepton flavor violation and seesaw symmetries
Aristizabal Sierra, Diego ULg

in Hyperfine Interactions (2013, February), 214

When the standard model is extended with right-handed neutrinos the symmetries of the resulting Lagrangian are enlarged with a new global U(1)R Abelian factor. In the context of minimal seesaw models we ... [more ▼]

When the standard model is extended with right-handed neutrinos the symmetries of the resulting Lagrangian are enlarged with a new global U(1)R Abelian factor. In the context of minimal seesaw models we analyze the implications of a slightly broken U(1)R symmetry on charged lepton flavor violating decays. We find, depending on the R-charge assignments, models where charged lepton flavor violating rates can be within measurable ranges. In particular, we show that in the resulting models due to the structure of the light neutrino mass matrix muon flavor violating decays are entirely determined by neutrino data (up to a normalization factor) and can be sizable in a wide right-handed neutrino mass range. [less ▲]

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See detailCollaborations distantes synchrones dans les pratiques de conception
Ben Rajeb, Samia ULg; Leclercq, Pierre ULg

in International Journal of Design Sciences and Technology (2013, January)

Cet article propose une analyse des pratiques de la collaboration architecturale dans des situations de travail distantes. Il s'intéresse en particulier à la mise en oeuvre d'outils pour le travail ... [more ▼]

Cet article propose une analyse des pratiques de la collaboration architecturale dans des situations de travail distantes. Il s'intéresse en particulier à la mise en oeuvre d'outils pour le travail synchrones dans les agences d'architecture. Il s'appuie sur l'observations in situ de trois situations qui illustrent successivement différents modes d'interaction : nous analyserons ainsi l'usage de la visioconférence, de l'écran partagé puis du studio distant collaboratif. Pour identifier quels rôles peuvent assurer ces différents outils numériques, notre méthodologie s'appuiera sur la catégorisation proposée par les concepts architecturologiques, décrivant les opérations de conception architecturale, complétées des opérations pragmatiques de collaboration. Une grille évaluative des opérations supportées respectivement par ces trois technologies identifiera leurs limitations, atouts et conditions d'opérabilité, permettant ainsi d'apprécier la mise en oeuvre actuelle et future des technologies collaboratives en agence d'architecture. [less ▲]

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See detailErythropoietin therapy after allogeneic hematopoietic cell transplantation : a prospective randomised trial.
JASPERS, Aurélie ULg; Baron, Frédéric ULg; WILLEMS, Evelyne ULg et al

in Belgian Journal of Hematology (2013, January)

Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO ... [more ▼]

Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO) therapy was very efficient when started one month after transplantation. We also demonstrated that anemia after nonmyeloabalative (NM) HCT was less sensitive to rhEPO therapy than after conventional allogeneic HCT. This prompted us to confirm these findings in a prospective randomised trial. One hundred and thirty-one patients were randomised (1:1) between no treatment (arm 1) or erythropoietin (Neorecormon) at the dose of 500 U/kg/week (arm 2). Once the target Hb (13g/dL) has been attained, the dose of rhEPO was reduced by half, while it was withheld when Hb was = 14g/dL. Cohort A included 42 patients on day 28 after myeloablative HCT, cohort B 39 patients on day 28 after NMHCT, and cohort C 50 patients on day 0 of NMHCT. Primary endpoints included proportion of complete correctors (i.e. patients reaching Hb = 13g/dL) and median time to achieve Hb correction in each arm. The proportion of complete correctors before day 126 posttransplant was 0% in group 1A vs 52.4% in group 2A, 0% in group 1B vs 69.5% in group 2B and 19.1% in group 1C vs 70.2% in group 2C. Median time to achieve Hb = 13g/dL was not reached in group 1B vs 49 days in group 2B; 363 and 59 days in groups 1A and 1B respectively and 363 and 87 days in groups 3A and 3B respectively (figure 1). Hb evolution in each group is shown in figure 2. Seventyone patients (47/62 in control groups and 24/57 in treated groups, p=0.0003) required red blood cell transfusions. The difference was most pronounced in cohort B. There was no difference in rates of thrombo-embolic events or other complications between the two arms. In conclusion, this is the first trial to demonstrate that EPO therapy hastens erythroid recovery and decreases transfusion requirements when started one month after allogeneic HCT. [less ▲]

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See detailSurface and lipid interaction properties of novel rhamnolipids to explain their eliciting activity
Nasir, Mehmet Nail ULg; Monhonval, Pierre; Nott, Katherine ULg et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 168

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See detailStrontium ranelate prevents radiological progression in patients with primary knee osteoarthritis
Cooper, C; Berembaum, F; Nash, P et al

in Osteoporosis International (2013), 24(1), 306-307

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See detailMise en image du spectacle et spectacularisation de l’image à l’âge baroque
Delfosse, Annick ULg; Dekoninck, Ralph; Delbeke, Maarten et al

in Degrés : Revue de Synthèses à Orientation Sémiologique (2013)

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See detailKoaleszenz in Extraktionskolonnen und Abscheidern
Pfennig, Andreas ULg; Buchbender, Florian; Chuttrakul, P et al

in Chemie Ingenieur Technik (2013)

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See detailPrediction of residual stresses by FE simulations on bimetallic work rolls during cooling
Neira Torres, Ingrid ULg; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in Computer Methods in Materials Science (2013), 13(1), 84-91

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic ... [more ▼]

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic roll studied in this paper is obtained from a vertical spin casting process followed by cooling and subsequent heat treatments. Failure of the compound roll sometimes occurs during the cooling stage of the casting route or later during the thermal treatments. It requires to deeply investigate the thermo mechanical metallurgical interactions generated during cooling and heat treatment in order to find the origin of cracks. For this purpose, a thermo metallurgic mechanical finite element model is used. However these numerical simulations require a high amount of mechanical, thermal and metallurgical parameters. In order to determinate these parameters, a study of available data for estimation of mechanical parameters was performed. Thermo physical parameters were obtained by DTA and DSC methods. Metallurgical characterization by inverse numerical method based on available CCT diagrams was performed to determine the TTT diagrams. First cooling numerical simulations are presented, allowing a rough estimate of residual stresses values and the identification of key parameters for predicting accurate residual stresses by sensitivity analysis. [less ▲]

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See detailSelf-shuffling words
Charlier, Emilie ULg; Kamae, Teturo; Puzynina, Svetlana et al

in Lecture Notes in Computer Science (2013)

In this paper we introduce and study a new property of infinite words which is invariant under the action of a morphism: We say an infinite word x, defined over a finite alphabet A, is self-shuffling if x ... [more ▼]

In this paper we introduce and study a new property of infinite words which is invariant under the action of a morphism: We say an infinite word x, defined over a finite alphabet A, is self-shuffling if x admits factorizations: x=\prod_{i=1}^\infty U_iV_i=\prod_{i=1}^\infty U_i=\prod_{i=1}^\infty V_i with U_i,V_i \in \A^+. In other words, there exists a shuffle of x with itself which reproduces x. The morphic image of any self-shuffling word is again self-shuffling. We prove that many important and well studied words are self-shuffling: This includes the Thue-Morse word and all Sturmian words (except those of the form aC where a is a letter and C is a characteristic Sturmian word). We further establish a number of necessary conditions for a word to be self-shuffling, and show that certain other important words (including the paper-folding word and infinite Lyndon words) are not self-shuffling. In addition to its morphic invariance, which can be used to show that one word is not the morphic image of another, this new notion has other unexpected applications: For instance, as a consequence of our characterization of self-shuffling Sturmian words, we recover a number theoretic result, originally due to Yasutomi, which characterizes pure morphic Sturmian words in the orbit of the characteristic. [less ▲]

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See detailAltered cartilage phenotype in mice lacking Sirt-1 gene
Gabay, Odile; Zaal, K; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2013), 21

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See detailSi isotope and Ge/Si ratios record successive cycles of dissolution/precipitation of pedogenic clay minerals
Cornelis, Jean-Thomas ULg; Weis, Dominique; Lavkulich, Les et al

in Mineralogical Magazine (2013), 77(5), 918

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See detailQuadripulse Repetitive Transcranial Magnetic Stimulation on Visual Cortex for Chronic Migraine Prevention: A Pilot-Trial
Sasso d'Elia, Tullia; Vigano, Alessandro; Fataki, Michel et al

in Cephalalgia : An International Journal of Headache (2013), 33(8), 49

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See detailImaging osteoarthritis using (18F)FPRGD2 PET/CT : observation and potential application.
WITHOFS, Nadia ULg; ALVAREZ MIEZENTSEVA, Victoria ULg; SIMONI, Paolo ULg et al

in Journal of Nuclear Medicine (The) (2013), 54(SUPPL), 250

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See detailStrontium ranelate effect on knee osteoarthritis progression : a MRI analysis
Genant, HK; Zaim, S; Guermazi, A et al

in Osteoporosis International (2013), 24(1), 312-313

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See detailReduction in VAP incidence by subglottic secretion drainage and antibiotic consumption in ICU patients
VAN CAUWENBERGE, Isabelle ULg; ANCION, Arnaud ULg; LAMBERMONT, Bernard ULg et al

in Intensive Care Medicine (2013), 39(Suppl 2), 465-4660898

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See detailPrognostic value of FDG PET/CT in patients with hepatocellular carcinoma treated with liver transplantation.
GOVAERTS, L.; DETRY, Olivier ULg; BLETARD, Noëlla ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2013), 2013(SUPPL), 287

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See detailLevels of Dechloranes and PBDEs in Serum from Central European Population
Brasseur, Catherine ULg; Focant, Jean-François ULg

in Organohalogen Compounds (2013), 75

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See detailModeling of non-covalent complexes of the cell-penetrating peptide CADY and its siRNA cargo
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Deshayes, Sébastien et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 63

CADY is a cell-penetrating peptide spontaneously making non-covalent complexes with short interfering RNAs (siRNAs) in water. Neither the structure of CADY nor that of the complexes is resolved. We have ... [more ▼]

CADY is a cell-penetrating peptide spontaneously making non-covalent complexes with short interfering RNAs (siRNAs) in water. Neither the structure of CADY nor that of the complexes is resolved. We have calculated and analyzed 3D models of CADY and of the non-covalent CADY–siRNA complexes in order to understand their formation and stabilization. Data from the ab initio calculations and molecular dynamics support that, in agreement with the experimental data, CADY is a polymorphic peptide partly helical. We calculated and compared several complexes with peptide/siRNA ratios of up to 40. The initial binding of CADYs is essentially due to the electrostatic interactions of the arginines with siRNA phosphates. Due to a repetitive arginine motif (XLWR(K)), CADYs can adopt multiple positions at the siRNA surface. Nevertheless, several complex properties are common: an average of 14 ± 1 CADYs is required to saturate a siRNA. The 40 CADYs/siRNA that is the optimal ratio for vector stability always corresponds to two layers of CADYs per siRNA and the peptide cage is stabilized by hydrophobic CADY–CADY contacts. The analysis demonstrates that the hydrophobicity, the positive charges and the polymorphism of CADY are mandatory to make stable the CADY–siRNA complexes. [less ▲]

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See detailThe general approach to the patient with osteoarthritis : is a treatment algorithm feasible ?
Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 385

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See detailSNR dependence of mean kurtosis and how to correct it
André, Elodie ULg; Phillips, Christophe ULg; Farrher, Ezequiel et al

in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society For Magnetic Resonance in Medicine. Scientific Meeting and Exhibition (2013), 21

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See detailPharmacological management : osteoporosis and osteoarthritis, similarities and differences
Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 75-76

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See detailPartonic Picture of Generalized Transverse Momentum Distributions
Liuti, Simonetta; Courtoy, Aurore ULg; Goldstein, Gary R. et al

in World Scientific (2013)

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See detailEvaluation de l'exposition professionnelle aux cytostatiques des travailleurs de deux services du CHU de Liège
Rusu, Dorina; DUBOIS, Nathalie ULg; Surleraux, Cécile et al

in Acta Clinica Belgica (2013), 68(6), 472

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See detailHow adaptation strategies of crops could counteract climate change effects? The case of four catchments in Wallonia, Belgium.
Bauwens, Alexandra ULg; Sohier, Catherine ULg; Degré, Aurore ULg

in Geophysical Research Abstracts (2013), 15

A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to significantly reduce crops’ yields under current agricultural practices ... [more ▼]

A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to significantly reduce crops’ yields under current agricultural practices. This contribution uses an agro-hydrological model in order to assess the potential effects of climate evolution on crop development, yield, and water balance for the main agricultural productions in the Meuse catchment. Erosion risk is also evaluated. We show that grasslands and maize yield decrease and yield variability increases under climate change scenarios. The leaf area index study permits to put in emphasis the earlier start of the vegetation due to warmer climate. It appears that all the sensitive stages occur earlier in the season and that crops are negatively affected by summer drought stress. The better understanding of crops development under evolving climate allows us to propose some changes in agricultural practices and to assess their effectiveness. We evaluate different strategies of adaptation in agricultural practices in order to reduce the potential negative effects of climate change on grasslands and maize production. Adaptation strategies proposed are advanced sowing and harvesting date, introduction of a cover crop for maize and advance in the cutting dates for grasslands. In the particular case of the Vesdre catchment, shifting the growth period of maize permits to avoid the water-deficit period and allow increased yield. This shift makes it possible to introduce a cover crop that will drastically reduce winter soil erosion. For grassland, the adjustment of the cutting dates favored the first cut and the earlier start of the vegetation. The second cut is less profitable due to summer drought stress. The vulnerability assessments focused on the main rotation encountered in the cultivated areas and in the difference in the cover type of these crops. [less ▲]

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See detailPatients' preferences for osteoporosis drug therapy : a discrete choice experiment
Hiligsmann, Mickaël ULg; Dellaert, B; Dirksen, C et al

in Osteoporosis International (2013), 24(1), 53

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See detailThe Enhancement of Secondary Succession by Western Lowland Gorillas (Gorilla gorilla gorilla) in a Moist Tropical Forest of Southeast Cameroon
Petre, Charles-Albert ULg; Haurez, Barbara ULg; Tagg, Nikki et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailTime-Controlled Cryogenic Zone Compression (tCZC) GC-HRMS, A Novel Tool fro Targetted Analysis at Uktra Trace Level
Krumwiede, D; Mehmlann, H; Focant, Jean-François ULg et al

in Organohalogen Compounds (2013), 75

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See detailThe Immunomodulating Peptide Thymosin Alpha 1 Has no Effect on Multiple Myeloma Evolution and on Immune Reconstitution
Binsfeld, Marilène ULg; Otjacques, Eléonore ULg; Hannon, Muriel ULg et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 41

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See detailBaseline measurements of COLL2-1 and COLL2-1 NO2 in urine are highly predictive of joint space narrowing in knee osteoarthritis
Henrotin, Yves ULg; Kraus, V.; Huebner, J. et al

in Annals of Rheumatic Diseases (2013)

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See detailInhibition of sclerostin with romosozumab in postmenopausal women with low BMD : phase 2 trial results
McClung, M; Grauer, A; Boonen, S et al

in Osteoporosis International (2013), 24(1), 38-39

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See detailComparison of Immune Reconstitution after Hematopoietic Stem Cell Transplantation with Flu-TBI versus TLI-ATG Conditioning
Hannon, Muriel ULg; Humblet-Baron, S.; Graux, C. et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 38

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See detailModeling of Dendritic Cell-based vaccination Immunotherapy using Artificial Neural Networks
Mehrian, Mohammad ULg; Arabameri, Abazar; Sedghi, Alireza et al

in Modeling of Dendritic Cell-based vaccination Immunotherapy using Artificial Neural Networks (2013)

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See detailProspective study of an advanced nurse triage for a target pathology at the admission in the emergency department
JOBE, Jérôme ULg; VANDERCLEYEN, C; Ghuysen, Alexandre ULg et al

in Acta Clinica Belgica (2013), 68(6), 2

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See detailChirurgie bariatrique chez le patient diabétique de type 1 : résultats d’une expérience limitée.
FRANCK, Marie ULg; DE FLINES, Jenny ULg; PAQUOT, Nicolas ULg et al

in Diabète & Métabolisme (2013), 39(suppl), 102

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See detailOn differentially dissipative dynamical systems
Forni, Fulvio ULg; Sepulchre, Rodolphe ULg

in IFAC-PapersOnLine website. (2013)

Dissipativity is an essential concept of systems theory. The paper provides an extension of dissipativity, named differential dissipativity, by lifting storage functions and supply rates to the tangent ... [more ▼]

Dissipativity is an essential concept of systems theory. The paper provides an extension of dissipativity, named differential dissipativity, by lifting storage functions and supply rates to the tangent bundle. Differential dissipativity is connected to incremental stability in the same way as dissipativity is connected to stability. It leads to a natural formulation of differential passivity when restricting to quadratic supply rates. The paper also shows that the interconnection of differentially passive systems is differentially passive, and provides preliminary examples of differentially passive electrical systems. [less ▲]

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See detailValidation of analytical method for the determination in serum of psychotropic drugs commonly prescribed in Rwanda by HPLC-DAD
Hahirwa, Innocent; Charlier, Corinne ULg; DENOOZ, Raphael ULg et al

in Acta Clinica Belgica (2013), 68(6), 479

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See detailL’incendie : feu purificateur ?
Close, Florence ULg

in Bulletin de la Société d'Art et d'Histoire du Diocèse de Liège (2013), LXX

Dans la nuit du 3 au 4 août 1312, la Cité de Liège est mise à feu et à sang. Sept siècles plus tard, la mémoire collective liégeoise compte encore cet évènement au nombre des jalons les plus tragiques de ... [more ▼]

Dans la nuit du 3 au 4 août 1312, la Cité de Liège est mise à feu et à sang. Sept siècles plus tard, la mémoire collective liégeoise compte encore cet évènement au nombre des jalons les plus tragiques de l’histoire de la Principauté. Les conditions dans lesquelles moururent les patriciens demeurent inqualifiables, de même que les moyens auxquels recourut la masse populaire révoltée pour venir à bout de son adversaire. Cet évènement anecdotique au regard de la grande histoire met en lumière la place ambivalente du feu dans la vie et la mentalité des hommes et des femmes du Moyen Âge. Il invite à une profonde réflexion mêlant des considérations juridiques, spirituelles, symboliques et anthropologiques [less ▲]

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See detailNutrition and bone health : turning beliefs into knowledge for healthy behaviour
Brandi, ML; Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 388-389

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women
Reginster, Jean-Yves ULg; Ellis, AG; Luo, X et al

in Osteoporosis International (2013), 24(1), 37

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See detailOn the Number of Abelian Bordered Words
Rampersad, Narad; Rigo, Michel ULg; Salimov, Pavel ULg

in Lecture Notes in Computer Science (2013), 7907

In the literature, many bijections between (labeled) Motzkin paths and various other combinatorial objects are studied. We consider abelian (un)bordered words and show the connection with irreducible ... [more ▼]

In the literature, many bijections between (labeled) Motzkin paths and various other combinatorial objects are studied. We consider abelian (un)bordered words and show the connection with irreducible symmetric Motzkin paths and paths in Z not returning to the origin. This study can be extended to abelian unbordered words over an arbitrary alphabet and we derive expressions to compute the number of these words. In particular, over a 3-letter alphabet, the connection with paths in the triangular lattice is made. Finally, we study the lengths of the abelian unbordered factors occurring in the Thue--Morse word. [less ▲]

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See detailRecensement des dosages d'alcool sanguin effectués dans le cadre de la sécurité routière
DEVILLE, Marine ULg; Charlier, Corinne ULg

in Acta Clinica Belgica (2013), 68(6), 479

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See detailGenetic analysis of pig survival in a crossbred population
Dufrasne, Marie ULg; Misztal, Ignacy; Tsuruta, Shogo et al

in Journal of Animal Science (2013), 91(E-Suppl.2), 193

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See detailDes ambassadeurs entre Liège et Bourgogne: Pour une étude des relations diplomatiques des pouvoirs liégeois avec les ducs Valois
Masson, Christophe ULg

in Publication du Centre Européen d'Etudes Bourguignonnes (2013), LIII(2013), 51-66

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See detailThe interdependent relationship between C dynamics and soil-forming processes in a podzollic chronosequence under a temperate rainforest.
Vermeire, Marie-Liesse; Lavkulich, Les; Cornelis, Jean-Thomas ULg

in Geophysical Research Abstracts (2013), 15

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See detailExtension of the Liège Intra Nuclear Cascade model to light ion-induced collisions for medical and space applications
Leray, S.; Mancusi, D.; Kaitaniemi, P. et al

in Journal of Physics: Conference Series (2013), 420

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See detailGenetic analysis of longitudinal measurements of feed intake in Piétrain sire lines
Dufrasne, Marie ULg; Jaspart, Véronique; Wavreille, José et al

in Journal of Animal Science (2013), 91(E-Suppl.2), 293

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See detailCorrelation between RNA and protein levels in a large european series from the LYSA
Bossard, C.; Dobay, M.P.; Lamant, L. et al

in Hematological Oncology (2013), 31 Suppl.1

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of ... [more ▼]

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of INO plus R-CVP in patients (pts) with relapsed/refractory CD22+ B-NHL. Efficacy data were also collected. Methods: Part 1 of this open-label study identified a maximum tolerated dose (MTD) of INO 0.8mg/m,2 on day 2 plus R-CVP (rituximab 375mg/m,2 cyclophosphamide 750mg/m,2 and vincristine 1.4mg/m,2 on day 1; prednisone 40mg/m,2 on days 1-5) every 21 days. Subsequently, pts were enrolled in the MTD confirmation cohort (part 2, n = 10), which required a dose-limiting toxicity rate of <33% in cycle 1 and <4 pts discontinuing prior to cycle 3 due to an adverse event (AE) in the MTD expansion cohort (part 3, n = 22), which explored preliminary activity. Results: Parts 2 and 3 enrolled 32 pts: 16 pts with diffuse large B-cell lymphoma, 15 with follicular lymphoma and one with mantle cell lymphoma. Median age was 64.5 years (range 44-81 years); 34% of pts had 1 prior regimen, 34% had 2, 28% had ≥3 and 3% had none (median 2; range 0-6).Median treatment duration was five cycles (range 1-6). Part 2 confirmed the MTD as standard dose R-CVP plus INO 0.8mg/m,2; 2/10 pts had a dose-limiting toxicity (grade 3 increased ALT/AST, grade 4 neutropenia requiring G-CSF). One pt discontinued because of an AE prior to cycle 3. Common treatment-related AEs were thrombocytopenia (78%), neutropenia (66%), fatigue (50%), leukopenia (50%), nausea (41%) and lymphopenia (38%); common grade 3/4 AEs were neutropenia (63%), thrombocytopenia (53%), leukopenia (38%) and lymphopenia (31%). There was one case of treatment-related fatal pneumonia with grade 4 neutropenia. Ten pts discontinued treatment due to AEs; thrombocytopenia/delayed platelet recovery was the leading cause (grade 1/2, n = 6; grade 3/4, n = 3). Objective response rate (ORR) was 77% (n = 24/31 evaluable pts), including 26% (n=8/31) with complete response (CR); three pts had stable disease. Of the pts with follicular lymphoma, ORR was 100% (n = 15/15), including seven pts with CR. Of the pts with diffuse large B-cell lymphoma, ORR was 60% (n = 9/16), including one pt with CR. Conclusions: Results suggest that INOplus R-CVP has acceptable toxicity and promising activity in relapsed/refractory CD22+ B-NHL. The most common grade 3/4 AEs were hematologic. Follow-up for progression-free and overall survival is ongoing. [less ▲]

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See detailSimultaneous fitting of statistical-model parameters to symmetric and asymmetric fission cross sections
Mancusi, Davide; Charity, R.J; Cugnon, Joseph ULg

in Journal of Physics: Conference Series (2013), 420

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See detailRisks factors for valvular regurgitations in 3499 equids: a cross-sectional study.
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Proceedings of the 2013 ACVIM Forum (2013)

Risk factors for valvular regurgitations (VR) have been suspected in equids, but no extensive epidemiologic study has been performed in a large mixed equine population. Therefore, the aim of this study ... [more ▼]

Risk factors for valvular regurgitations (VR) have been suspected in equids, but no extensive epidemiologic study has been performed in a large mixed equine population. Therefore, the aim of this study was to statistically test risk factors for VR in a large population of equids. Hospital records were reviewed for 3.499 equids, admitted at the internal medicine department of the Liege Equine Teaching Hospital between 1994 and 2011, aged ≥2 years, and which underwent thorough cardiac clinical evaluation. Of this population, 495 cases had ECG and echocardiography performed because of a clinical suspicion of cardiac disease. Chi-square test or logistic regressions (as appropriate) were used to test if breed, gender, age, body weight (BW), and co-existence of various cardiac diseases were risk factors for each VR. Moreover, the risk of development of congestive heart failure (CHF) was tested for each VR. Significance was set at p<0.05. Most of the studied animals were warmbloods, and observed prevalences were 4.4% for mitral regurgitation (MR), 2.1% for aortic regurgitation (AR), 1.7% for tricuspid regurgitation (TR), and 1.0% for pulmonary regurgitation (PR). Significant risk factors were male gender and increasing age for AR (OR=2.03, CI=1.07-4.94), and racehorses breed group and middle-age for TR (OR=4.36; CI=1.10-17.24). No effect of age or BW was demonstrated for MR. MR was the major valvular disease associated with atrial fibrillation (AF), ventricular tachyarrhythmia, PR and CHF. TR was also linked to AF, PR and CHF; but AR was not linked to CHF. In conclusion, several previously suspected risks factors for VR were confirmed statistically in this study and should be taken into account in health and athletic monitoring of horses presenting predisposing factors. [less ▲]

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See detailImage-guided failure assessment of human trabecular bone - Inverse finite element modelling for characterization of elastic properties
Zwahlen, Alexander; Christen, David; Ruffoni, Davide ULg et al

in BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK (2013), 58(1),

Local interpretation of micro finite element (mu FE) simulations has become important in different fields of bone biomechanics. Although on an apparent level mu FE has successfully been validated against ... [more ▼]

Local interpretation of micro finite element (mu FE) simulations has become important in different fields of bone biomechanics. Although on an apparent level mu FE has successfully been validated against experiments, local validations are sparse and limited by imaging resolution. At the tissue level heterogeneity of Young's modulus has been reported. Although non-uniform material distribution have been shown to only have a minor influence on the apparent material properties, its impact on local material behaviour is largely unknown. By combining image-guided failure assessment (IGFA) using synchrotron-based-micro-computed tomography, strain mapping and inverse mu FE modelling, we present an experimental and computational framework which will allow studying local effects of intratrabecular heterogeneity of the Young's modulus. [less ▲]

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See detailSTOP BANG but not BMI predicts postoperative obstructive apnoea and hypoxaemia after laparoscopic upper-abdominal surgery: 5AP2-5
Pirenne, S.; HANS, Grégory ULg; Joris, J. et al

in European Journal of Anaesthesiology (2013), 30

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See detailPrognostic value of FDG PET/CT in patients with lung tumors treated by Cyberknife.
LOVINFOSSE, Pierre ULg; JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg et al

in Journal of Nuclear Medicine (The) (2013), 54(SUPPL), 567

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See detailGenetics of body energy status of Holstein cows predicted by mid-infrared spectrometry
Bastin, Catherine ULg; Berry, D.; Gengler, Nicolas ULg et al

in Journal of Dairy Science (2013), 96(E-Suppl. 1),

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See detailSpectral Modelling of Massive Binary Systems: The Example of LZ Cep
Palate, Matthieu ULg; Rauw, Grégor ULg; Mahy, Laurent ULg

in Central European astrophysical bulletin (2013)

Despite their importance for many astrophysical processes, massive stars are still not fully understood. Massive binaries offer an attractive way to improve our knowledge of the fundamental properties of ... [more ▼]

Despite their importance for many astrophysical processes, massive stars are still not fully understood. Massive binaries offer an attractive way to improve our knowledge of the fundamental properties of these objects. However, some secondary effects are known to generate variations in the spectra of massive binaries, rendering their analyses more difficult. We present here a new approach to the computation of synthetic spectra of massive binaries at different phases of their orbital cycle. Our model starts with the Roche potential modified by radiation pressure and accounts for the influence of the companion star on the shape and physical properties of the stellar surface. We further account for gravity darkening and reflection effects to compute the surface temperature. Once the local gravity and temperature are determined, we interpolate in a grid of NLTE plan-parallel atmosphere model spectra to obtain the local contribution to the spectrum at each surface points. Then we sum all the contributions, accounting for the Doppler shift, and limb-darkening to obtain the total spectrum. The computation is repeated for different orbital phases and can be compared to the observations to determine the best parameters. We illustrate our method through the example of the LZ Cep system (O9III + ON9.7V). [less ▲]

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