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See detailA flow cytometric study on the effect of myeloperoxidase on stallion spermatozoal motility and structure
Ponthier, Jérôme ULg; Parrilla Hernandez, Sonia ULg; Van Den Berghe, Femke ULg et al

in Journal of Equine Veterinary Science (2012, August), 32(8), 509

Myeloperoxidase (MPO) is a pro-oxidant enzyme that is normally contained in neutrophils. MPO has recently been associated with keratinized cells and with decreased post-thaw motility in stallion semen [1 ... [more ▼]

Myeloperoxidase (MPO) is a pro-oxidant enzyme that is normally contained in neutrophils. MPO has recently been associated with keratinized cells and with decreased post-thaw motility in stallion semen [1]. The aim of the study was to determine effects of experimental addition of active MPO on motility, mitochondrial potential, apoptosis induction, membrane and acrosome integrity in equine semen. Three stallions were used and semen was collected four times. Extended (INRA96TM) semen was processed for density gradient centrifugation (Equipure Bottom Layer®) [2]. Purified pellet was re-extended to 100x106spermatozoa/ml in INRA96TM and divided in 3 samples. One sample was used for control and active human MPO (Calbiochem, Merck) was added in the other two samples to final concentration of 5 or 50 ng/ml. After incubation (2 hours, 20°C), motility was analysed with Computer Assisted Semen Analysis (IVOS, Hamilton-Throne, Beverly, MA, USA) and cytometric analyzes were perfomed with EasyCyte (IMV). Mitochondrial potential and apoptosis were assayed using Guava Mitopotential JC-1 and 7-AAD kit (Millipore). Membrane and acrosome integrity were respectively assayed with PI (Propidium Iodide) (Invitrogen) and PNA (Peanut Agglutinin-Fluorescein Iso Thio Cyanate) (Sigma-Aldrich). Statistical differences (p<0.05) were determined using Kruskall-Wallis test. No effect of the stallions was observed on parameters assayed in this study. Unlike total motility, progressive motility was decreased in both MPO concentrations (p<0.001). MPO addition had no effect on membrane and acrosome integrity. No differences were detected for the percentages of spermatozoa having polarised or depolarised mitochondria. Apoptosis, assayed by 7-AAD fluorescence, was not increased by the treatments. Our results agree with previously published effects of in vitro ROS production systems with xanthine oxidase [3], showing an effect on motility but no influence on mitochondria and membrane or acrosome integrity. However, membrane lipoperoxidation was increased by ROS in this study [3], and it could be linked to the impaired motility also observed in our protocol. Further studies with increasing concentrations of added MPO should be conducted to correlate motility with lipoperoxidation. References [1] Ponthier J, Desvals M, Franck T, de la Rebiere de Pouyade G, Spalart M, Palmer E, Serteyn D, Deleuze S. Myeloperoxidase in equine semen: Concentration and Localization during freezing processing. Journal of Equine Veterinary Science 2012;32: 32-37. [2] Edmond AJ, Teague SR, Brinsko SP, Comerford KL, Waite JA, Mancill SS, Love CC, Varner DD. Effect of density-gradient centrifugation on quality and recovery rate of equine spermatozoa. Animal Reproduction Science 2008;107: 318-318. [3] Baumber J, Ball BA, Gravance CG, Medina V, Davies-Morel MC. The effect of reactive oxygen species on equine sperm motility, viability, acrosomal integrity, mitochondrial membrane potential, and membrane lipid peroxidation. J Androl 2000;21: 895-902. [less ▲]

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See detailSquamous metaplasia of the prostate and diffuse alopecia in a 13-year-old castrated dog due to chronic ingestion of exogenous estradiol
Van Den Berghe, Femke ULg; Ponthier, Jérôme ULg; Deleuze, Stefan ULg

in Reproduction in Domestic Animals (2012, August), 47(S4), 561

Introduction. A 13-year old whippet with a generalized progressive alopecia since 2 years was referred to our clinic to perform a low-dose dexamethasone stimulation test and abdominal ultrasound to ... [more ▼]

Introduction. A 13-year old whippet with a generalized progressive alopecia since 2 years was referred to our clinic to perform a low-dose dexamethasone stimulation test and abdominal ultrasound to exclude or confirm Cushing disease. The dog had previously been treated with trilostane for 4 months without having any positive effects. Earlier blood analysis showed no significantly abnormalities and ACTH stimulation test was negative. Having bilateral cryptorchidism, the dog was castrated at young age. Clinical findings and treatment. Abdominal ultrasound revealed a slightly enlarged right adrenal gland (diameter of 1 cm at the cranial part). The prostate was enlarged and heterogeneous with multiple anechogenic cavities, indicating hormonal stimulation. Craniad the prostate and ventrally of the bladder, a hypoechogenic, oval structure (3 cm by 1.7 cm) could be seen, and was suspected to be a remaining cryptorchide testicle. Fine needle aspiration however showed that the structure contained a thick purulent liquid, with large amounts of polymorhonuclear white blood cells. Blood analysis revealed a leukocytosis (29370/mm3) with neutrophilia (23202/mm3). Low-dose dexamethasone test definitely excluded Cushing disease (basal cortisol levels 2,17 µg/dl; cortisol at 4 and 8 hours < 1 µg/dl). A prostatic wash was performed and revealed a severe prostatitis and presence of keratinized prostatic cells, indicating a squamous metaplasia of the prostate. Measurement of seric LH levels (LH Witness®, Synbiotics) showed an LH concentration lower than 1 ng/ml, indicating a hormonal negative feedback on the hypothalamo-hypophyso-gonadal axis. After a more thorough anamnesis, it became clear that the dog was licking and ingesting a transdermal estradiol containing cream (Estrogel®) from his owner, since two years, causing his symptoms. The dog was put on antibiotic treatment for the prostatitis (enrofloxacine 10 mg/kg SID) and underwent surgery to excise the abscess cranial of the prostate. The two ductuli deferentes were attached to this structure. Histopathological analysis revealed this tissue to be embryological remanents or a morphological anomaly with a urogenital origin. Control after 4 weeks showed that the prostate slightly decreased in volume, however, anechogenic cavities where still present of which one increased in volume. The alopecia was still present as well, both probably due to a prolonged action of the estrogens. Conclusion. Even though injectable estrogen preparations are not longer available in veterinary medicine in Europe, a thorough anamnesis towards other exogenous estrogen sources is still necessary and can reduce the number of supplementary exams performed. [less ▲]

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See detailMyeloperoxidase as an indicator of endometritis in the mare: preliminary results
Parrilla Hernandez, Sonia ULg; Franck, Thierry ULg; Ponthier, Jérôme ULg et al

in Reproduction in Domestic Animals (2012, August), 47(suppl 5), 65

Diagnosis of endometritis in the mare is routinely based on the presence of polymorphonuclear cells (PMNs) on endometrial smears. Studies show a relation between PMNs and myeloperoxidase (MPO), an enzyme ... [more ▼]

Diagnosis of endometritis in the mare is routinely based on the presence of polymorphonuclear cells (PMNs) on endometrial smears. Studies show a relation between PMNs and myeloperoxidase (MPO), an enzyme released by PMNs during degranulation or after cell lysis, in many fluids and tissues. The aims of this study were to assess the presence and concentration of MPO in the mare’s uterus, and to investigate its relation with PMNs. Thirty-six cycles from 28 mares (ages ranging from 6 to 22 years) were used. Endometrial cytological samples were obtained with a small volume uterine flush and either a uterine cotton swab or a cytobrush, when a follicle >35 mm was observed by ultrasound. The smears were stained with Diff-QuickÒ and one or more PMNs per field (400·) was diagnosed as endometritis. The supernatant of the flushes was used to measure MPO concentration with a specific equine MPO ELISA assay. Our results showed the presence of MPO in the equine uterus during oestrus (mean = 2839 + 2785). MPO concentrations were signifi- cantly (p < 0.05) higher in samples with positive cytological results. Occasionally, some samples with negative cytological results showed high MPO concentration, but the opposite was never observed. Clinical signs of endometritis are not always present, or they may be delayed. An early diagnostic improves the success of treatment. Our results show that high quantities of MPO in endometrial samples indicate the presence of PMNs. Further studies are needed to determine if MPO concentration could be routinely used as a tool of early detection of endometritis. [less ▲]

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See detailAnalytical criteria for use of MS/MS for determination of dioxins and dioxin-like PCBs in feed and food
Kotz, A; Malisch, R; Focant, Jean-François ULg et al

in Organohalogen Compounds (2012, August), 74

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See detailThe effect of homologous prostatic fluid on the parameters of dog semen extended and frozen in Tris-egg yolk and INRA Freeze: preliminary results
Stanescu, Pascal; Van Den Berghe, Femke ULg; Aissi, Adel et al

in Reproduction in Domestic Animals (2012, August), 47(s4), 431

Recent studies showed that the cryoprotector component of egg yolk for the freezing of canine semen is represented by the low density lipoproteins (LDL), while the others components of egg yolk have a ... [more ▼]

Recent studies showed that the cryoprotector component of egg yolk for the freezing of canine semen is represented by the low density lipoproteins (LDL), while the others components of egg yolk have a number of detrimental effects on the frozen-thawed canine semen. The aim of this study was to compare the effect of a LDL commercial extender used for stallion semen – INRA FreezeÒ (IMV Technologies, L¢Aigle, France) with a standard extender for dog semen containing Tris, fructose, glycerol and 20% egg yolk (TFG-EY). Since there are some conflicting reports concerning the effect of prostatic fluid on sperm function, we also investigated if the effect of post-thaw dilution with autologous prostatic fluid on viability, motility and acrosome status of frozen-thawed canine spermatozoa is correlated with the composition of the extender. Semen was collected from six Beagle dogs and each sperm rich fraction was divided in two parts: one was diluted with INRA FreezeÒ and the other with TFG-EY and frozen with the same protocol. The third fraction of each ejaculate was collected separately, centrifuged at 1118 · g for 10 min and the supernatant was frozen at )18°C until use. For each extender, two straws were thawed: one straw was diluted 1:2 with autologous prostatic fluid, while the other was not diluted at all. Motility (CASA, IVOS; Hamilton Thorne, USA), viability and acrosome status (Guava EasyCyteÒ flow cytom- eter; IMV Technologies, L¢Aigle, France), morphology (Diff-Quick stain) were assessed at 5 min, 1 h and 2 h post-thaw (T0, T1, T2). Statistical analyses were performed with IBM SPSS software (ver. 19 for Windows; IBM, New York, NY, USA). The results are presented as mean values and a p value <0.05 was considered statistically significant. Viability, total and progressive motility and the percentage Ó 2012 Blackwell Verlag GmbH 432 Abstracts of intact acrosomes were higher (p < 0.05) for the TFG-EY group with or without the addition of the prostatic fluid. The results for motility in the INRA Freeze group were dramatically low compared to the TFG-EY group. There were no significant differences regarding the morphology of fresh and frozen semen for any of the four groups. Addition of prostatic fluid for the TFG-EY group significantly reduced the total and progressive motility at T0, T1 and T2 (p < 0.05), but showed no influence for the INRA Freeze group. This data show that the effect of prostatic fluid regarding motility differs between the two extenders. This may illustrate either an inhibitory effect of some components of the INRA FreezeÒ on the noxious effects of the prostatic fluid or conversely an enhancing effect of the TFG-EY on those. Alternatively, it could be that low values obtained with INRA FreezeÒ did not permit highlighting the effects of prostatic fluid. [less ▲]

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See detailBenveniste serait-il aujourd’hui un linguiste de l’énonciation ?
[Lttr 13]; Badir, Sémir ULg; Polis, Stéphane ULg et al

in Arts et savoirs (2012, July 24), 2

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See detailMALDI MSI for ovarian cancer biomarkers research: latest developments of the technology for screening and tracking.
Longuespée, Rémi ULg

in Histochemistry & Cell Biology (2012, July), 138(1), 141-54

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See detailEffect of the milk recording time on the genetic parameters of milk production and mid-infrared milk components in Luxembourg dairy cattle
Arnould, Valérie ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Journal of Dairy Science (2012, July), 95

A particularity of the Luxembourg milk recording is the use of different schemes. Two principal schemes are applied: the scheme “S” applied on 69.1% of the total herds (n=712) and consisting in one ... [more ▼]

A particularity of the Luxembourg milk recording is the use of different schemes. Two principal schemes are applied: the scheme “S” applied on 69.1% of the total herds (n=712) and consisting in one proportionate sample of all daily milkings, and the scheme “T” (21.6% of the total herds) which consists in one sample of only one milking (morning or evening milking) (and alternating milking time from month to month). The problematic is that application of different schemes could influence the milk components (protein and fat yield) and the milk fat components (saturated and unsaturated groups of fatty acids) genetic parameters estimation and to prevent all comparisons between dairy population under different milk recording schemes. A total of 47,613 and 44,833 test-day records were obtained, respectively for schemes “S” and “T” from Holstein cows in first lactation in Luxembourg dairy herds. The used model included as fixed effects: herd x date of test, class of age, and month x year. Random effects were permanent environmental, additive genetics, and residual effects. The main objective of this work is to study the effect the choice of milk recording schemes (“S” or “T” schemes) on milk yield and milk components genetic parameters. A solution could be to add a fixed effect taking in account the milking time. The second objective is to study the effect of milking time (morning or evening) on genetic parameters estimated in the case of scheme “T”. According to the results, genetic parameters were statistically different between the schemes “S” and “T” for milk yield (P value < 0.0001). Further, the classifications of bulls according to their breeding values were very different when values were estimated on basis of scheme “S” or “T” (Spearman correlation value of 0.51 for milk yield for example). In conclusion, using several milk recording schemes do not allow any comparison of genetic parameters between dairy cattle’s. [less ▲]

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See detailMALDI MSI for ovarian cancer biomarkers research: latest developments of the technology for screening and tracking.
Longuespée, Rémi ULg

in Histochemistry & Cell Biology (2012, July), 138(1), 141-54

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See detailInvestigation on the High Efficiency Volume Bragg gratings performances for spectrometry in space environment: Preliminary results
Loicq, Jerôme ULg; Georges, Marc ULg; Gaspar Venancio, Luis Miguel

in Telescope and systems (2012, July)

The special properties of Volume Bragg Gratings (VBGs) make them good candidates for spectrometry applications where high spectral resolution, low level of straylight and low polarisation sensitivity are ... [more ▼]

The special properties of Volume Bragg Gratings (VBGs) make them good candidates for spectrometry applications where high spectral resolution, low level of straylight and low polarisation sensitivity are required. Therefore it is of interest to assess the maturity and suitability of VBGs as enabling technology for future ESA missions with demanding requirements for spectrometry. The VBGs suitability for space application is being investigated in the frame of a project led by CSL and funded by the European Space Agency. The goal of this work is twofold: first the theoretical advantages and drawbacks of VBGs with respect to other technologies with identical functionalities are assessed, and second the performances of VBG samples in a representative space environment are experimentally evaluated. The performances of samples of two VBGs technologies, the Photo-Thermo-Refractive (PTR) glass and the DiChromated Gelatine (DCG), are assessed and compared in the H, O2-B and NIR bands. The tests are performed under vacuum condition combined with temperature cycling in the range of 200 K to 300K. A dedicated test bench experiment is designed to evaluate the impact of temperature on the spectral efficiency and to determine the optical wavefront error of the diffracted beam. Furthermore the diffraction efficiency degradation under gamma irradiation is assessed. Finally the straylight, the diffraction efficiency under conical incidence and the polarisation sensitivity is evaluated. [less ▲]

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See detailA bone remodelling model for long term orthodontic tooth movement.
Mengoni, Marlène ULg; D'Otreppe, Vinciane ULg; Ponthot, Jean-Philippe ULg

in Journal of Biomechanics (2012, July), 45(Supplement 1), 180

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See detailMALDI MSI for ovarian cancer biomarkers research: latest developments of the technology for screening and tracking.
Longuespée, Rémi ULg

in Histochemistry & Cell Biology (2012, July), 138(1), 141-54

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See detailThe situation of gerontechnology in Belgium
Petermans, Jean ULg; LEJEUNE, CHRISTOPHE; GILLAIN, Daniel ULg

in GERONTECHNOLOGY (2012, June 26), 11(2), 269-270

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See detailSeverity of incident vertebral fracture and future fracture risk: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 716

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See detailGranulomatous meningo-encephalitis caused by Toxoplasma gondii in three bulls, a possible explanation for unexplained sporadic bovine meningo-encephalitis
Theron, Léonard ULg; Tabaran, F; Cassart, Dominique ULg et al

in Revista Portuguesa de Buiatria (2012, June), (Special Edition),

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See detailPrise en charge des brûlés en phase aigue : enquête européenne.
ROUSSEAU, Anne-Françoise ULg; LEDOUX, Didier ULg; MASSION, Paul ULg et al

in Brûlures. Revue Française de Brûlologie (2012, June), XIII(2), 60

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See detailChildren of lesbian parents: Research on family triadic interactions
Miscioscia, Marina ULg; Scarciotta, Lidia; D'Amore, Salvatore ULg et al

in Infant Mental Health Journal (2012, June), 33(3 Abstract Supplement), 26

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See detailSevere prevalent vertebral fractures predict subsequent vertebral and nonvertebral fractures: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 588

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See detailInvestigation of sudden death of calves after epileptic seizures due to hypomagnesaemia and hyperparathyroidism
Chevalier, Marine ULg; Lebreton, Pascal; Garnier, Catherine et al

in Revista Portuguesa de Buiatria (2012, June), (Special Edition),

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See detailRadiological and clinical profil of osteoarthritic patients undergoing of total joint replacement
Neuprez, Audrey ULg; François, Garance ULg; Bruyère, Olivier ULg et al

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 693

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See detailAssessment of quality of life in patients undergoing total joint replacement for OA of the lower limb
Neuprez, Audrey ULg; François, Garance ULg; Bruyère, Olivier ULg et al

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 693

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See detailInvestigation of body condition score and insulin sensitivity (RQUICKY) in downer cow syndrome
Bonvoisin, Marie ULg; Rollin, Frédéric ULg; Lebreton, Pascal et al

in Revista Portuguesa de Buiatria (2012, June), (Special Edition),

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See detailPerception, knowledge and use by general practitioners of Belgium of the FRAX tool
Bruyère, Olivier ULg; Nicolet, Delphine ULg; Compère, Stéphanie et al

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 716

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See detailEffect of mechanical weeding on wild Chamomile populations in winter wheat crop
Jaunard, Delphine ULg; Monty, Arnaud ULg; Henriet, François et al

in Communications in Agricultural and Applied Biological Sciences (2012, May 22)

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See detailEfficacy of a strontium ranelate 2 G/vitamin D3 1000 UI combination on the correction of vitamin D insufficiency
Rizzoli, R; Dawson-Hughes, B; Kaufman, JM et al

in Osteoporosis International (2012, May), 23(S2), 225

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See detailLiège experience in donation after cardiac death liver transplantation: 2003-2011
Le Dinh, Hieu ULg; DELWAIDE, Jean ULg; MONARD, Josée ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 6811

Objectives: Results of DCD-LT at the University Hospital of Liège were evaluated from 2003 to 2011. Methods: Medical records of 56 DCD liver recipients were retrospectively reviewed with regard to patient ... [more ▼]

Objectives: Results of DCD-LT at the University Hospital of Liège were evaluated from 2003 to 2011. Methods: Medical records of 56 DCD liver recipients were retrospectively reviewed with regard to patient and graft survivals and biliary complications. Mean follow-up was 26.4 months. Mean donor age was 56.3±14.5 years (25 - 83). Donor causes of death were due to anoxia (51.8%), stroke (32.1%) and head trauma (14.3%). Mean WIT, CIT and suture time were 20.5±7.1min (10 – 39), 265.6±85.1min (105 – 576), and 40.8±7.8 min (25 – 61), respectively. 95% of liver grafts were locally shared. HTK was the most commonly used perfusion solution (86%). Mean recipient age was 56.6±10.5 years (29 – 73). Indications for LT included ESLD (53.6%) and HCC (46.6%). Mean MELD score at transplant was 15.6±6.1points (6 – 40). Results: No primary non-function grafts. Mean peak serum AST and bilirubin levels were 2520±3621UI/L and 50.2±49.2mg/L, respectively. Eight patients (14.3%) developed biliary complications. No intra-hepatic bile duct strictures or re-transplantation. Global patient and graft survival was 92.6% at 3 months, 92.6% at 1 year, 73.8% at 3 years and 60% at 5 years. Death-censored patient and graft survival at the corresponding time points was 92.6%, 92.6%, 87.7% and 87.7%. Thirteen liver grafts were lost during follow-up exclusively due to recipient deaths. The rate of HCC recurrence was 33.3%. Conclusions: Controlled DCD donors are a valuable source of transplantable liver grafts. Primary results are encouraging and apparently as good as those from brain-dead donation LT essentially due to short WIT and CIT. [less ▲]

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See detailAutomatic real-time collection of RCS of airplanes in a real bistatic low-frequency configuration using a software defined passive radar based on illuminators of opportunity
Pisane, Jonathan ULg; Azarian, Sylvain; Lesturgie, Marc et al

in Proceedings of the 2012 IEEE Radar Conference (2012, May)

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See detailDREAM 2012: DEVELOPMENT OF LAPAROSCOPIC SURGERY AT THE UNIVERSITY HOSPITAL OF KINSHASA, DRC
Nsadi Fwene, Berthier ULg; Veyi, D; Kazadi, J et al

in Acta Chirurgica Belgica (2012, May), 112(3), 8240

Objectives: The technical nature of laparoscopy, and the required specific laparoscopic tools and medical skills, may render this approach difficult in developing countries. We hypothesized that ... [more ▼]

Objectives: The technical nature of laparoscopy, and the required specific laparoscopic tools and medical skills, may render this approach difficult in developing countries. We hypothesized that laparoscopy may be developed in the Cliniques Universitaires de Kinshasa (CUK), and may be cost-effective. The final aim of this program is to bring the benefits of laparoscopy to the DRC population, by allowance of adequate training on the UNIKIN personnel, including anaesthetists, surgeons and nurses, who in the future will have to locally form the DRC medical and nursery students. Methods: With the financial support from Wallonie-Bruxelles International (WBI), a complete CUK team, including a surgeon (2 years training in Belgium), an anaesthetist and nurses, were trained in Belgium and then afterwards in DRC. The laparoscopic equipment was sent to Kinshasa, and three theoretical and practical missions of Belgian teams were organised. Results: Over a 2 year period, 116 laparoscopic procedure were performed, including 32 appendectomies, 41 cholecystectomies, 11 hernia repairs, 9 laparoscopy explorations for peritoneal carcinoma assessment and biopsy, 8 procedures for catheter of dialysis peritoneal, 5 gynecologics procedures, and 10 other miscellaneous procedures. Conclusions: A joined approach, taking into account on one hand the training of the skills locally trained to adapt itself to some difficulties, on the other hand institutions of scientific support and a real program and local will of development of this new procedure are the wages of development, accessibility and durability of such news approach in developing countries. All University and non-University team willing to join such a project are welcome. [less ▲]

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See detailResults of kidney transplantation from controlled donors after cardio-circulatory death: a single center experience
Le Dinh, Hieu ULg; WEEKERS, Laurent ULg; BONVOISIN, Catherine ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 667

Objectives: The aim of this study was to determine results of kidney transplantation (KT) from controlled donation after cardio-circulatory death (DCD). Primary end-points were graft and patient survival ... [more ▼]

Objectives: The aim of this study was to determine results of kidney transplantation (KT) from controlled donation after cardio-circulatory death (DCD). Primary end-points were graft and patient survival, and post-transplant complications. The influence of delayed graft function (DGF) on graft survival and DGF risk factors were analyzed as secondary end-points. Methods: This is a retrospective mono-center review of a consecutive series of 80 DCD-KT performed at the University Hospital of Sart Tilman, University of Liège, between Jan 2005 and Dec 2011. Mean patient follow-up was 28.5 months. Results: Overall graft survival was 93.7%, 89.5%, 85% and 81.3% at 3 months, 1 year, 3 and 5 years, respectively. Death-censored graft survival at the corresponding time points was 93.7%, 93.7%, 90.8% and 90.8%. Main cause of graft loss was patient’s death with a functioning graft. No primary non-function grafts were encountered. Renal graft function was suboptimal at hospital discharge, but nearly normalized at 3 months. DGF was observed in 36% of all DCD-KT. DGF significantly increased post-operative length of hospitalization, but had no deleterious impact on graft function or survival. Donor body mass index (BMI) ≥30 kg/m2, recipient BMI ≥30 kg/m2 and pre-transplant dialysis duration significantly increased the risk of DGF in a multivariate logistic regression analysis (p < 0.05). Conclusions: Despite a higher rate of DGF, controlled DCD-KT offers a valuable contribution to the pool of deceased donor kidney grafts, with comparable mid-term results to those procured after brain death. [less ▲]

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See detailEFFECT OF PARECOXIB, A SELECTIVE COX-2 INHIBITOR, IN THE PREVENTION OF POSTOPERATIVE ADHESIONS IN A RAT MODEL
Arung Kalau, Willy ULg; Drion, Pierre ULg; CHERAMY-BIEN, Jean-Paul ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 8444

Objectives: Postoperative peritoneal adhesions are frequent after abdominal surgery. Many preventive agents have been tried in animal models and in clinical trials, but up to now, there has been no ... [more ▼]

Objectives: Postoperative peritoneal adhesions are frequent after abdominal surgery. Many preventive agents have been tried in animal models and in clinical trials, but up to now, there has been no definitive strategy to prevent their formation. In this study, the effectiveness of parecoxib (Dynastat®), a selective cyclooxygenase-2 inhibitor, in preventing experimental intra-abdominal adhesions in rats was studied. Methods: Thirty male rats who underwent a primary surgical procedure aiming at inducing peritoneal injury to produce intraabdominal adhesion, were randomized in three groups: (A) control group, no therapy; (B) intraperitoneal (IP) parecoxib group; (C) intramuscular (IM) parecoxib group. Ten days later, a xyphopubic midline incision was performed and the whole abdominal cavity was explored to score the peritoneal adhesions. Results: Twenty-three rats developed adhesions, 9 (100%) in group A, 7 (70%) in group B and 4 (40%) in group C (P=0.01). The extent and severity scores of adhesion were significantly lower in groups B and C than those in control group (p<0.001). Type of adhesions was measured at 2.25 ± 0.67 in group A, 1.20 ± 0.86 in group B and 0.82 ± 0.80 in group C. This was significantly different between group A and B (p<0.001), between A and C (p<0.001). But no significant difference was found between group B and C (p=0.17). Conclusions: In this study, we found a significant effect on parecoxib in the prevention of postoperative adhesions. But, without avoiding completely the formation of adhesion, parecoxib reduces significantly extent and severity of postoperative adhesions in rats treated with IP or IM parecoxib administration. [less ▲]

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See detailLaparoscopic liver resection: a single center experience
SZECEL, Delphine ULg; DE ROOVER, Arnaud ULg; DELWAIDE, Jean ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 631

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See detailWhat is the potential increase of the heart graft pool by cardiac donation after circulatory death?
NOTERDAEME, Timothée; HANS, Marie-France ULg; NELLESSEN, Eric ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 668

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See detailINTRA-TUMORAL HETEROGENEITY AND RATIONAL SELECTION OF ANTIGENS FOR TARGETED THERAPY OF LIVER METASTASES
Turtoi, Andrei ULg; Blomme, Arnaud ULg; Delvaux, David ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 8953

Objectives: Targeted therapies of liver metastases are gaining a major stake in current and future treatment options. However, the malignant lesions are heterogeneous in nature offering niches for cancer ... [more ▼]

Objectives: Targeted therapies of liver metastases are gaining a major stake in current and future treatment options. However, the malignant lesions are heterogeneous in nature offering niches for cancer cells causing treatment resistance and relapse. Therefore, a rational strategy is needed to select targetable antigens that would overcome this intra-tumoral heterogeneity. Methods: After ethical committee approval, 48 fresh liver metastases of colorectal origin were prospectively collected from patients undergoing liver resection. Here we macroscopically divided the lesion in different zones and generated a unique quantitative picture of the proteome heterogeneity in colorectal carcinoma liver metastases. Particular focus was laid on accessible proteins, a protein subclass comprising cell membrane associated and extracellular proteins. Accordingly, the tissues were ex-vivo biotinylated, affinity purified and analyzed for each zone separately using nano-UPLC-MSe proteomics technique. In total over 1500 unique proteins were statistically divided into different patterns of expression. Results: We have generated a quantitative picture of the proteome heterogeneity in colorectal carcinoma liver metastases. The study offers insight into novel targets but also antigens against which the antibodies are already involved in clinical trials or treatment of liver metastases. Extensive clustering and validation experiments highlight novel markers that offer the potential to homogeneously cover the metastatic lesion and become better targets. Conclusions: Two such antigens, LTBP2 and TGFBI were selected for functional analysis in colorectal carcinoma cells. In vitro and in vivo experiments showed that in particular TGFBI is relevant for migration and proliferation capacity of colorectal cancer cells. The suppression of this protein led to significant inhibition of tumor growth, crystalizing it as bona fide target for the development of anti-metastases therapies. [less ▲]

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See detailINTRAPERITONEAL ADHESIONS AFTER OPEN OR LAPAROSCOPIC ABDOMINAL PROCEDURE: AN EXPERIMENTAL STUDY IN THE RAT
Arung, Willy; Drion, Pierre ULg; CHERAMY-BIEN, Jean-Paul ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 8546

Objectives: Adhesion formation is common after abdominal surgery. The incidence and severity of adhesion formation following open or laparoscopic surgery remain controversial. The role of CO2 ... [more ▼]

Objectives: Adhesion formation is common after abdominal surgery. The incidence and severity of adhesion formation following open or laparoscopic surgery remain controversial. The role of CO2 pneumoperitoneum is also largely discussed. This study aimed to compare adhesion formation following peritoneal injury by electrocoagulation performed through open or laparoscopic procedures in a rat model. Methods: Sixty male rats were randomized to undergo a 1.5cm peritoneal injury with unipolar cautery under general anesthesia: open surgery (group A, n=20), laparoscopic surgery with CO2 pneumoperitoneum (group B, n=20) and laparoscopic surgery with air pneumoperitoneum (group C, n=20). Duration of the procedures was fixed at 90 minutes in all groups, and pneumoperitoneum pressure at 10mmHg. Ten days later, the animals underwent a secondary laparotomy to score peritoneal adhesions using qualitative and quantitative parameters. Results: Forty-five rats developed at least one adhesion, respectively 95% in group A, 83% in group B and 55% in group C (P<0.01; Group C vs Group A, P<0.01). According to number, thickness, tenacity, vascularization, extent, type, and grading according to Zühkle classification, no significant difference was observed between groups A and B. The distribution of adhesions after open surgery was significantly different than after laparoscopic surgery (P<0.001). Interestingly, group C rats developed significantly less adhesions at the traumatized site, and their adhesions had less severe qualitative scores compared to open surgery (P<0.01). Conclusions: In this animal model, CO2 laparoscopic surgery did not decrease the formation of postoperative adhesion, compared to open surgery. The difference with the animals operated with air pneumoperitoneum emphasizes the role of CO2 in peritoneal injury leading to adhesion formation. [less ▲]

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See detailFeasibility of scanning fetal anatomy in the first trimester of gestation
To, Hong ULg

in European Federation of Societies for Ultrasound in Medicine and Biology (2012, April 22)

Objectives: This study aims to evaluate the feasibility of performing an anatomy scanned for fetal abnormalities at the time of nuchal translucency (NT) measurement in Vietnamese population Material and ... [more ▼]

Objectives: This study aims to evaluate the feasibility of performing an anatomy scanned for fetal abnormalities at the time of nuchal translucency (NT) measurement in Vietnamese population Material and methods: In a prospective study, 2500 singleton pregnancies measured fetal NT and scanned structural anatomy in the first trimester; then checked fetal morphology systematically at 18-24 weeks and followed up to their delivery. According to ultrasonographic abnormalities and amniocentesis, we evaluated the detection rate of ultrasound for aneuploidy in the first and second trimester of gestation. Results: The sensitivity and specificity of ultrasound for aneuploidy was 17.2% and 99.7%, respectively. All 13 cases of fetal ultrasonographic anomalies related significantly with an increased NT (≥ 2.4mm) (p < 0.001). 30.8% of these abnormalities that included cystic hygroma, omphalocele and holoprosencephaly were detected at 11-13.6 weeks’ gestation. In the second trimester scanning, 69.2% of major structural anomalies found and the detection rate of central nervous system malformation, abnormal heart, abdominal wall defect, face anomaly and skeletal deformities were 85.7%, 100%, 66.7%, 50% and 75%, alternatively. Conclusion: Scanning of fetal anatomy at the time of NT measuring is useful to detect fetal abnormalities, especially aneuploidy in Vietnamese pregnancies. [less ▲]

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See detailRisk factor of fetal chromosomal aberrations in the south of Vietnam
To, Hong ULg

in European Federation of Societies for Ultrasound in Medicine and Biology (2012, April 22)

Objectives: The aim of this study is to find the risk factors of fetal chromosomal aberrations in order to classify a high risk pregnancy in our prenatal care unit. Material and methods: A prospective ... [more ▼]

Objectives: The aim of this study is to find the risk factors of fetal chromosomal aberrations in order to classify a high risk pregnancy in our prenatal care unit. Material and methods: A prospective study was carried out during one year in our clinic. 523 cases of amniocentesis was followed up and evaluated the relation with abnormal result (fetal aneuploidies) and the risk factors such as advanced maternal age (≥ 35 years old), parity, habitation, positive triple test (≥ 1/250), fetal malformation history and abnormal signs in the first and second trimester scanning. Results: The incidence of fetal aneuploidy was 3.4% (18/523 [95%CI: 2.1-5.4%]) and the trisomy 21 showed the most common in these chromosomal aberrations (67%). The younger women (< 35 years old), nulliparous, positive triple test and abnormal ultrasonographic findings (included increased nuchal translucency [≥ 2.4mm], absent nasal bone in the first trimester scanning and/or echogenic nodule in ventricular) was identified as the risk factors of fetal aneuploidies (OR was 2.3 [95%CI: 0.8-6.7], 4.0 [95%CI: 1.4-13.2], 3.3 [95%CI: 0.3-33.5] and 9.4 [95%CI: 1.1-79.2], respectively). The abnormal ultrasonographic findings found a relation significantly with abnormal chromosomes (p=0.04). Conclusion: Abnormal ultrasonographic findings in the first and second trimester were the important markers for predicting fetal aneuploidy, especially trisomy 21. [less ▲]

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See detailLa bande dessinée belge avant Hergé. Quelle histoire ?
Paques, Frédéric ULg

in Comicalités : Études de Culture Graphique (2012, April 11)

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See detailHumidity 3D field comparisons between GNSS tomography, IASI satellite observations and ALARO model
Brenot, Hugues; Champollion, Cedric; Deckmyn, Alex et al

in Geophysical Research Abstracts (2012, April), 14

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See detailA prospective study of cardiac valvular status in patients treated with cabergoline for Endocrine Disease
VROONEN, Laurent ULg; Lancellotti, Patrizio ULg; Tome Garcia, M et al

in Annales d'Endocrinologie (2012, April), 73(2), 148

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See detailExpression of specific pathways in the inflamed synovial membrane of osteoarthritis patient: Identification of new potential key intermediates
Lambert, Cécile ULg; Dubuc, Jean-Emile; Hennuy, Benoît ULg et al

in Osteoarthritis and Cartilage (2012, April), 20(Supplement 1), 56

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal ... [more ▼]

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal/reactive (N/R) and inflammatory (I) synovial membranes zones, we investigated the gene expression profiles of synovial cells from these areas and identified differentially regulated pathways. <br />Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling between N/R and I areas was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I areas was based on paired t-test where N/R and I were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Western blot was performed to confirm certain intermediate expression. <br />Results: From among 47000 probes, 17500 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 896 differentially expressed genes between N/R and I zones were identified. Among these, 576 genes were upregulated (I/NR > 1.5) and 320 downregulated (I/NR < 0.75). With Ingenuity Pathways Analysis, a significant number of the top ranking differentially expressed genes were identified as inflammatory, Wnt and angiogenic pathways. Interleukin (IL)-6 and -8, chemokines (CXCL1, CXCL2, CXCL5, CXCL6, CXCL16) and arachidonate 5-lipoxygenase (ALOX5) were identified as the most upregulated in I zones in the inflammatory pathway. Interestingly, the alarmin S100A9 was found strongly upregulated in this pathway. Wnt5A and LRP (Low density lipoprotein receptor-related protein) 5 were upregulated whereas FZD (Frizzled homolog) 2 and DKK (dickkopf homolog) 3 were downregulated in the Wnt signaling pathway. Finally, stanniocalcin (STC)-1, an intermediate in angiogenesis was identified as the most upregulated gene in I zones compared to N/R zones. This difference of expression was confirmed at the protein level. <br />Conclusions: Using a unique culture system, this study is the first to identify different expression pattern between two areas of synovial membrane from the same OA patient. These differences concern several key pathways involved in OA pathogenesis, i.e. inflammation, Wnt and angiogenesis. This analysis also provided interesting information regarding new potent intermediates as S100A9 and STC-1. They could be potential targets for chondroitin sulfate, one of the most used molecules in the management of OA. New experiments are being perfomed at the moment to elucidate the potential effect of this molecule on these specific differentially expressed genes in the same culture system. [less ▲]

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See detailClinical characterization of cabergoline resistant prolactinomas : a multicenter experience on 92 patients
VROONEN, Laurent ULg; Jaffrain Rea, ML; PETROSSIANS, Patrick ULg et al

in Annales d'Endocrinologie (2012, April), 73(2), 153

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See detailTHE RESPONSE OF ACETOBACTER SENEGALENSIS TO STRESSORS: A STUDY TOWARDS IMPROVEMENT OF VINEGAR STARTER PRODUCTION
Shafiei, Rasoul ULg; Thonart, Philippe ULg

in Acetic Acid Bacteria (2012, April)

Acetic acid bacteria encounter various harsh conditions during acetic acid fermentation. Ethanol as the main substrate and acetic acid as the major product at low pH can influence deeply on the cellular ... [more ▼]

Acetic acid bacteria encounter various harsh conditions during acetic acid fermentation. Ethanol as the main substrate and acetic acid as the major product at low pH can influence deeply on the cellular functions of acetic acid bacteria. In previous studies in CWBI, Acetobacter senegalensis was used for production of dried vinegar starters; however the impact of stressors (ethanol and acetic acid) on A. senegalensis remained unclear. In this study, different techniques such as flow cytometry, culturability on solid medium and 2-DiGE were used comparatively to investigate the effect of carbon sources of inoculum media on the tolerance of A. senegalensis to stressors. Analysis of respiration system by flow cytometric methods showed that the presence of 2% (v/v) acetic acid in inoculum medium, in one hand, causes 80% of cells to continue to do respiration after a sudden exposure to 1- 3% (v/v) acetic acid in stress media while 89.7% of cells grown in glucose appeared as dead cells after an abrupt exposure to 3%(v/v) of acetic acid. On the other hand, 59.2% and 49.33% of cells grown in the presence of 2% (v/v) of acetic acid could maintain their entire membrane integrity after exposure to 1% and 3% (v/v) of acetic acid, respectively. Inoculum medium contained 5% (v/v) of ethanol as a carbon source enabled about 90% of cells to keep their growing capacities after a sudden exposure to 3% acetic acid. In contrast, just 40% of cells grown in glucose as a carbon source maintained their culturability on solid medium after exposure to 1% acetic acid. A similar profile of culturability was observed for the cells grown in 5% (v/v) ethanol or 2% (v/v) of acetic acid. A proteomic approach (2-DiGE) was used to analyze proteins expressed in the presence of different carbon sources. Differentially expressed proteins were mainly associated with energy metabolism, carbohydrate metabolisms, folding, sorting and degradation processes. The relative abundance of proteins was extensively different for cell grown in glucose compared with protein contents of cells grown in ethanol or acetic acid. In conclusion, production of a cost effective vinegar starter needs a qualified biomass which tolerates ethanol and acetic acid. Tolerance of A. senegalensis to acetic acid depends to a great extent on the composition of the medium which cells grow in. In spite of low adaption to acetic acid for cell grown in glucose, using ethanol or acetic acid in inoculum media renders a physiological state in A. senegelensis which enables it to cope with higher concentration of acetic acid readily, this biomass has a potential to be used as a starter [less ▲]

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See detailEvaluation of three immunoassays for serodiagnosis of human Mycoplasma pneumoniae infection
HUYNEN, Pascale ULg; TOUSSAINT, Françoise ULg; HAYETTE, Marie-Pierre ULg et al

in Clinical Microbiology & Infection (2012, April), 18(S3), 231

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See detailAMICE: erste internationale Modellrechnung der Maas
Becker, Bernhard; Patzke, Simone; Detrembleur, Sylvain ULg et al

in Forum für Hydrologie und Wasserbewirtschaftung (2012, March 22), 12(31), 165-170

Im Rahmen des AMICE-Projektes wurde eine erste zusammenhängende internationale Modellrechnung für den gesamten Flusslauf der Maas inklusive des Nebenflusses Rur durchgeführt. Dazu wurden die in den ... [more ▼]

Im Rahmen des AMICE-Projektes wurde eine erste zusammenhängende internationale Modellrechnung für den gesamten Flusslauf der Maas inklusive des Nebenflusses Rur durchgeführt. Dazu wurden die in den Anrainerstaaten Frankreich, Belgien, Deutschland und der Niederlande vorgehaltenen numerischen Modelle verwendet. Die Randbedingungen dieser Modelle wurden in einem iterativen Prozess abgeglichen. Die Ergebnisse der zusammenhängenden Simulation tragen zunächst zu einem besseren Systemverständnis bei. Im weiteren Verlauf des Projektes fließen sie in eine Risikobetrachtung ein und werden zur Bewertung von Maßnahmen zur Reduzierung des Hochwasserrisikos vor dem Hintergrund zu erwartender Änderung der Bemessungsgrößen infolge einer erwarteten Klimaänderung herangezogen. [less ▲]

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See detailLA FALSIFICATION DES MEDICAMENTS
Marini Djang'Eing'A, Roland ULg

in Forum Pharmaceutique (2012, March 16), -(-), 16

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See detailHigh-resolution spectropolarimetric observations of hot subdwarfs
Petit, P.; Van Grootel, Valérie ULg; Bagnulo, S. et al

in Leaflet - Astronomical Society of the Pacific (2012, March 01), 452

We report on high-resolution spectropolarimetric observations of the hot subdwarf stars HD 76431 and Feige 66, using the ESPaDOnS echelle spectropolarimeter at CFHT. We compute cross-correlation Stokes I ... [more ▼]

We report on high-resolution spectropolarimetric observations of the hot subdwarf stars HD 76431 and Feige 66, using the ESPaDOnS echelle spectropolarimeter at CFHT. We compute cross-correlation Stokes I and V line profiles to enhance the signal-to-noise ratio. We then average all available cross-correlation profiles of each star to further decrease the noise level. Although both targets were previously reported to host kilo-gauss magnetic fields, we do not derive any evidence of large-scale photospheric fields from our sets of observations, in spite of tight error bars on the longitudinal field of the order of 60 gauss for HD 76431 and 200 gauss for Feige 66. A new analysis of FORS1 observations of HD 76431, which provided the basis for the original claim of field detection, confirms the absence of any detectable Zeeman signature, with an error bar of about 100 gauss on the longitudinal magnetic field. [less ▲]

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See detailAutomata-Based Symbolic Representations of Polyhedra
Boigelot, Bernard ULg; Brusten, Julien ULg; Degbomont, Jean-François ULg

in Lecture Notes in Computer Science (2012, March), 7183

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See detailStrontium ranelate reduces the number of radiological or radioclinical progressors in patients with primary knee osteoarthritis
Reginster, Jean-Yves ULg; Chapurlat, R; Christiansen, C et al

in Osteoporosis International (2012, March), 23(S2), 366-367

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See detailWhat are the most important medication attributes for patients with osteoporosis ? Results from a qualitative study
Hiligsmann, Mickaël ULg; Van Durme, C; Geusens, P et al

in Osteoporosis International (2012, March), 23(S2), 81-82

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See detailEfficacy of once-yearly zoledronic acid 5 mg in men with osteoporosis with different levels of serum total testosterone
Boonen, S; Reginster, Jean-Yves ULg; Kaufman, JM et al

in Osteoporosis International (2012, March), 23(S2), 79-80

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See detailDenosumab treatment of postmenopausal women with osteoporosis for 6 years : results from the first 3 years of the freedom extension
Papapoulos, S; Brown, JP; Chapurlat, R et al

in Osteoporosis International (2012, March), 23(S2), 76

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See detailAMP-activated protein kinase controls liposaccharide-induced hyperpermeability
Castanares-Zapatero, Diego; Overtus, M; Communi, Didier et al

in Critical Care (2012, March), 16(suppl 1), 17

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK ... [more ▼]

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK) has been shown to modulate cytoskeleton and could mediate endothelial permeability. Our hypothesis is that AMPK controls sepsis-induced hyperpermeability in the heart and is involved in septic cardiomyopathy. Sepsis was induced by intraperitoneal injection of liposaccharide, 10 mg/kg (LPS). Alpha-1 AMPK knockout mice (α1KO) were compared with wild-type. Vascular permeability was characterized by Evans blue extravasation. Inflammatory cytokine mRNA expression was determined by qPCR analysis. Left ventricular mass was assessed by echocardiography. In addition, to emphasize the beneficial role of AMPK on heart vascular permeability, AMPK activator (acadesine) was administered to C57Bl6 mice before LPS injection. The ANOVA test with Bonferroni's post hoc test and the log-rank test were used. P < 0.05 was considered as significant. Increased cardiac vascular permeability was observed in the LPS group in comparison to untreated animals (2.5% vs. 16%; P < 0.05). The α1KO mice exhibited an increase vascular permeability after LPS injection in comparison to wild-type mice (41.5% vs. 16%; P < 0.05). α1KO animals had a significant mortality increase after LPS injection (70% vs. 10%; P < 0.05). LPS markedly induced the production of proinflammatory cytokines (TNFα, IL-1β, IL-6) that were significantly higher in the α1KO animals. More importantly, LPS treatment leads to an increased left ventricular mass in the α1KO mice within 24 hours, suggesting the onset of edema. Finally LPS-induced vascular hyperpermeability was greatly reduced after AMPK activation by acadesine (13.2% vs. 40%; P < 0.05). AMPK importantly regulates cardiac vascular permeability and could control the sepsis-induced cardiomyopathy. AMPK could represent a new pharmacological target of sepsis. [less ▲]

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of nonvertebral fractures in high-risk postmenopausal osteoporosis population
Ellis, A; Jansen, J; Luo, X et al

in Osteoporosis International (2012, March), 23(S2), 64-65

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See detailPerception, knowledge and use by general practitioners of Belgium of the FRAX tool
Bruyère, Olivier ULg; Nicolet, Delphine ULg; Compère, Stéphanie et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 363-364

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See detailLong-term (3 years) reproducibility for the radiological assessment of knee osteoarthritis
DEROISY, Rita ULg; Bruyère, Olivier ULg; Gensburger, Deborah et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 219-220

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See detailCost-effectiveness of bazedoxifene compared with raloxifene in the treatment of postmenopausal osteoporotic women
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 312-313

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See detailRadiological and clinical profil of osteoarthritic patients undergoing of total joint replacement
Neuprez, Audrey ULg; François, Garance ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 129-130

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See detailAssessment of joint space narrowing in knee osteoarthritis has good long-term intercentre reproducibility when read in pairs with a semi-automated device
Gensburger, Deborah; DEROISY, Rita ULg; Arlot, Monique et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 247-248

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See detailEffect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
Bruyère, Olivier ULg; Zegels, Brigitte ULg; LEONORI, Lorenzo ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 362-363

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See detailAn economic evaluation of strontium ranelate for the treatment of male osteoporosis
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 305-306

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See detailSevere prevalent vertebral fractures predict subsequent vertebral and nonvertebral fractures: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 361-362

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See detailSeverity of incident vertebral fracture and future fracture risk: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 60-61

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See detailDifference between total and intact assays for N-terminal propeptide of type I procollagen in renal impaired patients
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; ROUSSELLE, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Supplement 2), 339

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See detailEstablishment of parathyroid hormone (PTH) reference on 10 different assay kits: impact of the recruitment of the population
CAVALIER, Etienne ULg; SOUBERBIELLE, Jean-Claude

in Osteoporosis International (2012, March), 23(Supplement 2), 360

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See detailStructure modifying effects of strontium ranelate in knee osteoarthritis
Reginster, Jean-Yves ULg; Chapurlat, R; Christiaensen, C et al

in Osteoporosis International (2012, March), 23(S2), 58-59

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See detailStrontium ranelate uncouples bone formation from bone resorption in male osteoporotic patients
COLLETTE, Julien ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2012, March), 23(S2), 365-366

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See detailStrontium ranelate and risk of venous thromboembolism (VTE) : an update of a retrospective cohort study in the UK general practice research database (GPRD)
Cooper, C; Deltour, N; Speirs, C et al

in Osteoporosis International (2012, March), 23(S2), 364-365

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See detailEstimation of genetic parameters for methane indicator traits based on milk fatty acids in dual purpose Belgian blue cattle
Kandel, Purna Bhadra ULg; Soyeurt, Hélène ULg; Gengler, Nicolas ULg

in Communications in Agricultural and Applied Biological Sciences (2012, February 10), 77(1), 21-25

The genetic parameters of CH4 indicators were estimated by single trait test-day models from 16,825 records collected on Walloon Dual Purpose Belgium Blue cows in their first 3 lactations. Fatty acid ... [more ▼]

The genetic parameters of CH4 indicators were estimated by single trait test-day models from 16,825 records collected on Walloon Dual Purpose Belgium Blue cows in their first 3 lactations. Fatty acid based CH4 indicators published in the literature were predicted from milk mid-infrared spectra using 597 calibration samples. For the indicator showing the highest link (R2 =0.88) with SF6 CH4 data, the average daily heritability was 0.21, 0.20 and 0.10 for each lactation, respectively. The sire genetic variability was on average 2.82 kg2 of CH4 per lactation. The genetic difference between the sires having cows eructing higher and lower CH4 was 10 kg of CH4 averaged per lactation. In conclusion, CH4 indicators can be predicted by MIR and the genetic variability of these traits seems to exist. [less ▲]

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See detailApport des troponines T et I ultrasensibles dans le diabète
LE GOFF, Caroline ULg; LAURENT, Terry ULg; GARWEG, Christophe ULg et al

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2012, February), 27(1), 40

Introduction : Le diabète atteint environ 3% de la population française. Or, cette maladie expose à l'apparition précoce de complications cardiovasculaires. Les troponines de nouvelles générations ... [more ▼]

Introduction : Le diabète atteint environ 3% de la population française. Or, cette maladie expose à l'apparition précoce de complications cardiovasculaires. Les troponines de nouvelles générations hautement sensibles pourraient être un bon outil diagnostic pour mettre en évidence des macroou micro-angiopathies non diagnostiquée chez ces patients. Le but de notre étude était de comparer la performance de la troponine T ultrasensible (hsTnT) (Roche Diagnostic) avec la troponine I ultrasensible (TnI II) (Abbott Diagnostic) chez le sujet diabétique. Matériel et méthodes : Vingt patients diabétiques (âge moyen : 52.6 ± 8.4 ans) ont été sélectionnés sur le critère d’un taux d’hémoglobine glyquée (HbA1c) élevé. Ces sujets ont été comparés à vingt sujets contrôles d’âge moyen : 60.05 ± 2.86 ans. Les patients atteints d’insuffisance rénale et d’affections cardiovasculaires ont été exclus. Les analyses ont été réalisées sur du plasma hépariné lithium. La hsTnT a été dosée par électrochemiluminescence sur le Modular E (Roche Diagnostic). Abbott utilise des microparticules chemiluminescentes pour le dosage de la TnI II sur l’ARCHITECT i. Résultats : Les sujets diabétiques ont un taux plasmatique de hsTnT représenté par les valeurs suivantes [médiane (1er quartile, 3ème quartile)] : 0,007 (0,03 ; 0,018) ng/mL ; alors que les sujets contrôles négatifs présentent les valeurs suivantes : 0,003 (0,003 ; 0,004) ng/mL. La différence de taux de hsTnT observée entre ces 2 populations est statistiquement significative (p = 0,000922). Pour la TnI II, on observe un taux plasmatique de: 0,004 (0,003 ; 0,075) ng/mL chez les sujets diabétiques et 0,002 (0,001 ; 0,005) ng/mL chez les sujets contrôles. La différence de taux de TnI II observée entre ces 2 populations n’est pas statistiquement significative (p > 0,005). Discussion-conclusion : Au décours d’un diabète, il apparait que les taux de hsTnT sont augmentés de façon significative par rapport au groupe des contrôles négatifs. Si les taux hsTnT augmentent chez le diabétique, il semblerait normal qu’il en soit de même pour la TnI II, vu que ces deux marqueurs sont intimement liés. Nous ne l’avons pas observé mais ceci peut être du à la plus faible performance analytique du dosage de la TnI II utilisé. Cette libération de hsTnT dans le sang peut être due aux micro- et macro-angiopathies au niveau des coronaires induites au cours d’un diabète. [less ▲]

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See detailA candidate cell of origin for cervical cancer
Herfs, Michael ULg; Yamamoto; Laury et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2012, February), 25(2), 4-552

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See detailDynamic Prediction of Energy Delivery Capacity of Power Networks : Unlocking the Value of Real-Time Measurements.
Schell, Peter; Jones, Lauren; Mack, Philippe et al

in Proceedings of the third IEEE PES Conference on Innovative Smart Grid Technologies (2012, January)

This paper describes recent advances in prediction software using advanced data-mining tools, and shows how this can significantly increase the operational value of the data gathered. These new tools ... [more ▼]

This paper describes recent advances in prediction software using advanced data-mining tools, and shows how this can significantly increase the operational value of the data gathered. These new tools allow for new operational procedures to be defined that increase the usages of the network without decreasing security of supply. We will use the example of dynamic line rating, i.e. determining the thermal rating of an overhead line based on real-time environmental parameters (temperature, wind speed & direction and solar radiation) to highlight how the use of numerical data-mining tools can help us reliably predict future behavior of power networks. [less ▲]

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See detailLa nécessité d'un inventaire du patrimoine culturel immatériel
Lempereur, Françoise ULg

in Géants d'ici et d'ailleurs (2012, January), (6-7), 24-30

Destinée essentiellement aux institutions et groupements qui ont en charge la sauvegarde du patrimoine culturel immatériel, cette présentation rapide justifie l'inventorisation de ce patrimoine, en ... [more ▼]

Destinée essentiellement aux institutions et groupements qui ont en charge la sauvegarde du patrimoine culturel immatériel, cette présentation rapide justifie l'inventorisation de ce patrimoine, en définit les responsabilités et propose une méthodologie de collectage et de mise à disposition publique des contenus [less ▲]

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See detailNodal staging of head and neck squamous cell carcinomas : impact of a dedicated PET/CT protocol.
MINON, AL.; CABAY, Jean-Evrard ULg; DEMEZ, Pierre ULg et al

in Journal of Nuclear Medicine (The) (2012), 53(SUPPL), 1354

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Frontiers in Human Neuroscience (2012)

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See detailPhase Change Memories challenges: A material and process perspective
Maitrejean, S.; Ghezzi, G.; Gourvest, E. et al

in 2012 IEEE International Interconnect Technology Conference, IITC 2012 (2012)

Among all the new memories concepts, Phase Change Memories (PCM) is one of the most promising. However, various challenges remain. This paper reviews the materials and processes required to face these ... [more ▼]

Among all the new memories concepts, Phase Change Memories (PCM) is one of the most promising. However, various challenges remain. This paper reviews the materials and processes required to face these challenges. As an example, attention will be made on the effect of Phase change material composition on stability of the amorphous phase i.e. on the retention of the information. Additionally, it is showed how specific processes such as CVD or ALD can be developed in order to minimize the current required to amorphize the phase change material i.e. to reset the device. Finally, with the perspectives of the advanced integration nodes, experimental results on the effect of scaling on phase transformation are presented and discussed. © 2012 IEEE. [less ▲]

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See detailComparison of Immune Reconstitution after Hematopoietic Stem Cell Transplantation with Flu-TBI versus TLI-ATG Conditioning
Hannon, Muriel ULg; Humblet-Baron, S.; Graux, C. et al

in Haematologica (2012), 97(Supplement 1), 180

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See detailComputer-based monitoring of global cardiovascular dynamics during acute pulmonary embolism and septic shock in swine
Revie, JA; Stevenson, D; Chase, JG et al

in Critical Care (2012), 16 (Suppl 1)

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See detailConnectivity within the default mode network is related to working memory performance in young but not elderly healthy adults
Yakushev, Igor; Chételat, Gael; Fischer, Florian et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2012), 8(4), 81

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See detailLANDSAFE: LANDING SITE RISK ANALYSIS SOFTWARE FRAMEWORK
Schmidt, Ralph; Bostelmann, Jonas; Cornet, Yves ULg et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2012), XXXIX(B4), 505-510

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful ... [more ▼]

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful landing a careful risk analysis has to be carried out. This is comprised of identifying favorable target areas and evaluating the surface conditions in these areas. Features like craters, boulders, steep slopes, rough surfaces and shadow areas have to be identified in order to assess the risk associated to a landing site in terms of a successful touchdown and subsequent surface operation of the lander. In addition, global illumination conditions at the landing site have to be simulated and analyzed. The Landing Site Risk Analysis software framework (LandSAfe) is a system for the analysis, selection and certification of safe landing sites on the lunar surface. LandSAfe generates several data products including high resolution digital terrain models (DTMs), hazard maps, illumination maps, temperature maps and surface reflectance maps which assist the user in evaluating potential landing site candidates. This paper presents the LandSAfe system and describes the methods and products of the different modules. For one candidate landing site on the rim of Shackleton crater at the south pole of the Moon a high resolution DTM is showcased. * Corresponding [less ▲]

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See detailTi impact in C-doped phase-change memories compliant to Pb-free soldering reflow
Perniola, L.; Noe, Pascal ULg; Hubert, Q. et al

in Technical Digest - International Electron Devices Meeting, IEDM (2012)

In this paper, we present a thorough physical-chemical analysis of an engineered PCM stack, where the integration of C-doping and the use of a Ti top layer allow obtaining an Amorphous As-Deposited (A-AD ... [more ▼]

In this paper, we present a thorough physical-chemical analysis of an engineered PCM stack, where the integration of C-doping and the use of a Ti top layer allow obtaining an Amorphous As-Deposited (A-AD) phase stable against Back End-Of-Line (BEOL) thermal budget. This PCM stack is then integrated in devices, which are extensively tested in order to validate a novel pre-coding technique compliant to the Pb-free soldering reflow issue. Finally, an original design to optimize the distribution dispersion is presented. © 2012 IEEE. [less ▲]

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See detail139 DOES QUALITY OF RADIOTHERAPY PREDICT OUTCOMES OF MULTICENTRE CLINICAL TRIALS? THE EORTC RADIATION ONCOLOGY GROUP EXPERIENCE.
Fairchild, Alysa; Collette, Laurence; Hurkmans, Coen W. et al

in Radiotherapy & Oncology (2012), 102

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See detailThe elusiveness of multifragmentation footprints in 1-GeV proton-nucleus reactions
Mancusi, D; Boudard, A; Cugnon, Joseph ULg et al

in EPJ Web of Conferences (2012), 31

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See detailEP-1420 ADAPTIVE CLINICAL COMMISSIONING OF MONACO VMAT: MAXIMIZING EFFICACY WITHOUT SACRIFICING SAFETY
GULYBAN, Akos ULg; Oltenau, A. M. L.; Vercauteren, T. et al

in Radiotherapy & Oncology (2012), 103

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See detailOC-0501 IRRADIATION OF THE LEFT VENTRICLE OF THE HEART IS CORRELATED WITH POST-TREATMENT DYSPNEA IN NSCLC PATIENTS
Nalbantov, G.; De Ruysscher, Dirk; Vandecasteele, K. et al

in Radiotherapy & Oncology (2012), 103

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See detailCompression test for metal characterization using digital image correlation and inverse modeling
Tuninetti Vásquez, Victor ULg; Gilles, Gaëtan ULg; Péron-Lührs, Vincent ULg et al

in Procedia IUTAM (2012)

In the case of sheet metal characterization, compression tests at normal direction of the sheet can be done by means of the layer compression test. Circular cylinder specimens are commonly used for ... [more ▼]

In the case of sheet metal characterization, compression tests at normal direction of the sheet can be done by means of the layer compression test. Circular cylinder specimens are commonly used for compression test but the complicated layer alignment is time consuming and may induce a wrong anisotropy characterization. This final goal explains the interest of working on elliptic shape. In this article, an elliptical cylinder specimen is proposed and tested for bulk Titanium alloy. Full-field optical technique (3D Digital Image Correlation) is used for displacement measurements by means of three camera systems (Limess), which allows out-of-plane displacement/strain fields on around 300° of the specimen. The use of this technique easily provides accurate barreling profile used to compute Coulomb friction coefficient by using inverse method. [less ▲]

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See detail(18F)FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas : correlation with histopathology.
WITHOFS, Nadia ULg; SIGNOLLE, N.; NZARAMBA, EM. et al

in Journal of Nuclear Medicine (The) (2012), 53(SUPPL), 1647

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See detailFrom Food Crisis to Analytical Strategies
Focant, Jean-François ULg

in Organohalogen Compounds (2012), 74

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