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See detailStrontium ranelate effect on knee osteoarthritis progression : a MRI analysis
Genant, HK; Zaim, S; Guermazi, A et al

in Osteoporosis International (2013), 24(1), 312-313

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See detailImaging osteoarthritis using (18F)FPRGD2 PET/CT : observation and potential application.
WITHOFS, Nadia ULg; ALVAREZ MIEZENTSEVA, Victoria ULg; SIMONI, Paolo ULg et al

in Journal of Nuclear Medicine (The) (2013), 54(SUPPL), 250

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See detailHydrological and geopedological dynamics of a forested slope
Deraedt, Deborah ULg; Degré, Aurore ULg; Colinet, Gilles ULg

in Geophysical Research Abstracts (2013), 15

Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the ... [more ▼]

Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the knowledge and the modelling of this environment. Here is the aim of this study. The studied slope is located on the Houille watershed in the West of the Belgian Ardenne (50 1’47”N, 4 53’22”E) on a silty rocky soil. The site is situated under a Douglas fir (Pseudotsuga menziesii (MIRB.) FRANCO) and spruce stand cover (Picea abies (L.) Karst). It is about 160 meters long with a North-West facing slope between 7 and 55%. The goal of the study is : - to characterise the hydrological and pedogeological dynamics along a forested slope, - to compare these dynamics with the tree growth. For the geopedological part of the study, eight pits were dug to describe the soil and take some soil samples used for granulometric, chemical, etc. analysis. We have used geophysical methods (Electrical Resistivity Tomography and Ground Penetrating Radar) to estimate the soil depth. As for the hydrological part of this study, moisture sensors (capacitive and TDR) have been installed in the pits along the slope. A dye tracing test has been performed to underline the preferential flow and the importance of the subsurface flow. Several trees have been equipped with dendrometers and some measures of the LAI and the height of the trees are planned. [less ▲]

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See detailPrognostic value of FDG PET/CT in patients with hepatocellular carcinoma treated with liver transplantation.
GOVAERTS, L.; DETRY, Olivier ULg; BLETARD, Noëlla ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2013), 2013(SUPPL), 287

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See detailLevels of Dechloranes and PBDEs in Serum from Central European Population
Brasseur, Catherine ULg; Focant, Jean-François ULg

in Organohalogen Compounds (2013), 75

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See detailThe general approach to the patient with osteoarthritis : is a treatment algorithm feasible ?
Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 385

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See detailBehavioural Ecology of Bonobos (Pan paniscus) in the Forest-Savannah Mosaics of Western Democratic Republic of Congo
Vimond, Marie; Serckx, Adeline ULg; Beudels-Jamar, Roseline et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013)

The long-term survival of the Endangered bonobo (IUCN, 2012) will depend on well thought out conservation programmes that need to be built both upon the species’ ecological requirements and local socio ... [more ▼]

The long-term survival of the Endangered bonobo (IUCN, 2012) will depend on well thought out conservation programmes that need to be built both upon the species’ ecological requirements and local socio-economics realities. Yet there is still a lot to find out, including information on the species geographical distribution. In 2005, the presence of a western population was confirmed in the forest-savannah mosaic in the south-western part of the Lake Tumba Landscape. With the exception of an early study carried out in Lukuru, the species is mainly known from lowland rainforest research sites in the Cuvette Centrale. The western forest-savannah mosaic is an ecotone with a marked seasonal pattern, a high variability of habitats and monthly variations in fruit production. All this leads to spatio-temporal variation of food availability. In order to increase studies and monitoring of this unique population, WWF initiated a habituation process of two groups of bonobos 6 years ago. The groups are now semi-habituated, making the collection of direct daily observations possible. Our objective is to describe the behavioural strategies developed by this population in order to cope with spatio-temporal variations of food availability. This will be approached by identifying daily activity, ranging and grouping patterns, in order to understand how they affect social structure. It should also allow us to define the use of savannahs. Our findings will help determine specific conservations measures for this endangered species. [less ▲]

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See detailPharmacological management : osteoporosis and osteoarthritis, similarities and differences
Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 75-76

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See detailAnalysis of $\alpha_s$ from the realization of quark-hadron duality
Courtoy, Aurore ULg; Liuti, Simonetta

in World Scientific (2013)

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See detailEvaluation de l'exposition professionnelle aux cytostatiques des travailleurs de deux services du CHU de Liège
Rusu, Dorina; DUBOIS, Nathalie ULg; Surleraux, Cécile et al

in Acta Clinica Belgica (2013), 68(6), 472

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See detailOleuropein or rutin consumption decreases the spontaneous development of OA in Hartley guinea pig
Sanchez, Christelle ULg; Horcajada, Marie-Noëlle; Membrez, Fanny et al

in Arthritis and Rheumatism (2013), 65

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See detailTime-Controlled Cryogenic Zone Compression (tCZC) GC-HRMS, A Novel Tool fro Targetted Analysis at Uktra Trace Level
Krumwiede, D; Mehmlann, H; Focant, Jean-François ULg et al

in Organohalogen Compounds (2013), 75

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See detailHow adaptation strategies of crops could counteract climate change effects? The case of four catchments in Wallonia, Belgium.
Bauwens, Alexandra ULg; Sohier, Catherine ULg; Degré, Aurore ULg

in Geophysical Research Abstracts (2013), 15

A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to significantly reduce crops’ yields under current agricultural practices ... [more ▼]

A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to significantly reduce crops’ yields under current agricultural practices. This contribution uses an agro-hydrological model in order to assess the potential effects of climate evolution on crop development, yield, and water balance for the main agricultural productions in the Meuse catchment. Erosion risk is also evaluated. We show that grasslands and maize yield decrease and yield variability increases under climate change scenarios. The leaf area index study permits to put in emphasis the earlier start of the vegetation due to warmer climate. It appears that all the sensitive stages occur earlier in the season and that crops are negatively affected by summer drought stress. The better understanding of crops development under evolving climate allows us to propose some changes in agricultural practices and to assess their effectiveness. We evaluate different strategies of adaptation in agricultural practices in order to reduce the potential negative effects of climate change on grasslands and maize production. Adaptation strategies proposed are advanced sowing and harvesting date, introduction of a cover crop for maize and advance in the cutting dates for grasslands. In the particular case of the Vesdre catchment, shifting the growth period of maize permits to avoid the water-deficit period and allow increased yield. This shift makes it possible to introduce a cover crop that will drastically reduce winter soil erosion. For grassland, the adjustment of the cutting dates favored the first cut and the earlier start of the vegetation. The second cut is less profitable due to summer drought stress. The vulnerability assessments focused on the main rotation encountered in the cultivated areas and in the difference in the cover type of these crops. [less ▲]

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See detailProspective study of an advanced nurse triage for a target pathology at the admission in the emergency department
JOBE, Jérôme ULg; VANDERCLEYEN, C; Ghuysen, Alexandre ULg et al

in Acta Clinica Belgica (2013), 68(6), 2

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See detailPatients' preferences for osteoporosis drug therapy : a discrete choice experiment
Hiligsmann, Mickaël ULg; Dellaert, B; Dirksen, C et al

in Osteoporosis International (2013), 24(1), 53

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See detailPrediction of residual stresses by FE simulations on bimetallic work rolls during cooling
Neira Torres, Ingrid ULg; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in Computer Methods in Materials Science (2013), 13(1), 84-91

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic ... [more ▼]

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic roll studied in this paper is obtained from a vertical spin casting process followed by cooling and subsequent heat treatments. Failure of the compound roll sometimes occurs during the cooling stage of the casting route or later during the thermal treatments. It requires to deeply investigate the thermo mechanical metallurgical interactions generated during cooling and heat treatment in order to find the origin of cracks. For this purpose, a thermo metallurgic mechanical finite element model is used. However these numerical simulations require a high amount of mechanical, thermal and metallurgical parameters. In order to determinate these parameters, a study of available data for estimation of mechanical parameters was performed. Thermo physical parameters were obtained by DTA and DSC methods. Metallurgical characterization by inverse numerical method based on available CCT diagrams was performed to determine the TTT diagrams. First cooling numerical simulations are presented, allowing a rough estimate of residual stresses values and the identification of key parameters for predicting accurate residual stresses by sensitivity analysis. [less ▲]

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See detailEstimation of the fascine efficiency in terms of runoff infiltration and sediments deposition
Degré, Aurore ULg; Pineux, Nathalie ULg; Cantreul, Vincent ULg et al

in Geophysical Research Abstracts (2013), 15

Runoff inundations and mudflows are more and more frequent phenomena. In 2011, Belgium had a lot of its municipalities affected by this problematic. Since then, mitigation measures are more and more set ... [more ▼]

Runoff inundations and mudflows are more and more frequent phenomena. In 2011, Belgium had a lot of its municipalities affected by this problematic. Since then, mitigation measures are more and more set up in agricultural watersheds. The fascines are one of these measures which allow to protect the public and private infrastructures and in the same way, which don’t reduce the famers productivity. They consist in branches faggots piled up between two rows of stakes. These linear constructions are mainly put in place across concentrated runoff axis in order to slow down the water and to filter the mud. Only few quantifications of their effectiveness (in terms of flow and concentration water reduction) exist and are however needed to better recommend these types of mitigation measures. Our experiment aims at measuring discharge and mud concentration reduction due to the fascines in a completely defined context. The tests were realised through fascines planted in field border. A watertight surface of 2,45m to 0,80m carries the water to the fascines. Three types of fascines were tested (willow wood fascine, straw fascine, straw compacted fascine), three different water flows were applied (0,5L/s, 3L/s and 6L/s) and three water concentration in dry soil (13g/L, 26g/L, 38g/L) were used. The different factor combinations were tested. The results show that we can expect a reduction of 60% of the flow for the biggest water flows (proportional efficiency with the water flow). The factor interaction study doesn’t allow to see a difference between the type. About the sediment water concentration, the filtration can reach 50%, the fascine with wood faggots showing a better efficiency. Finally, the difference between the fascine type show that straw fascine can support a biggest watershed (25 hectares) than the wood faggot fascine can (5-10 hectares) but during a smaller return period (one year against five years). [less ▲]

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See detailInhibition of sclerostin with romosozumab in postmenopausal women with low BMD : phase 2 trial results
McClung, M; Grauer, A; Boonen, S et al

in Osteoporosis International (2013), 24(1), 38-39

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See detailBlood lead, urinary lead, urinary δ-aminolevulinic acid and urinary porphyrins levels among people living in kinshasa, D.R. Congo : a pilot biomonitoring study
Mputu Malolo, Corneille-Liévin; Ndelo di Phanzu, Josaphat; Marini Djang'Eing'A, Roland ULg et al

in Acta Clinica Belgica (2013), 68(6), 475

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See detailValidation of analytical method for the determination in serum of psychotropic drugs commonly prescribed in Rwanda by HPLC-DAD
Hahirwa, Innocent; Charlier, Corinne ULg; DENOOZ, Raphael ULg et al

in Acta Clinica Belgica (2013), 68(6), 479

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See detailProcessing of Ti alloys by additive manufacturing: a comparison of the microstructures obtained by laser cladding, selective laser melting and electron beam melting
Reginster, Sylvie ULg; Mertens, Anne ULg; Paydas, Hakan ULg et al

in Materials Science Forum (2013), 765

Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the ... [more ▼]

Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the restoration - of complex and (almost) fully dense parts from Ti alloys. Both techniques involve the melting of a metallic powder with a laser. In the SLM process, the metallic powder is deposited layer by layer in a powder bed and then molten locally according to the desired shape, whereas in LC, the metallic powder is directly projected onto a substrate through a nozzle coaxial with the laser beam. The present research aims at comparing Ti-6Al-4V samples processed by these two techniques with reference samples produced by electron beam melting (EBM), another well established additive manufacturing process (patented by Arcam AB Company) in which a powder bed is molten locally by means of an electron beam. In all three processes, the melt pool undergoes an ultrafast cooling and solidifies very rapidly once the beam has left the area, thus giving rise to strongly out-of-equilibrium microstructures. Yet, each one of these processes also has its own specificities e.g. in terms of scanning strategy and of working atmosphere (low vacuum vs. protective Ar flow). In the present work, the microstructures obtained by these three processes have been compared in details, with a particular attention for characteristics such as porosity, grain size, and the various phases present. Since epitaxial growth of the newly deposited layer on the material previously solidified has been shown [1, 2] to exert a strong influence on the microstructure and on the resulting mechanical properties, great care has been taken to study the microstructural anisotropy associated with each one of the three processes. [less ▲]

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See detailModeling of Dendritic Cell-based vaccination Immunotherapy using Artificial Neural Networks
Mehrian, Mohammad ULg; Arabameri, Abazar; Sedghi, Alireza et al

in Modeling of Dendritic Cell-based vaccination Immunotherapy using Artificial Neural Networks (2013)

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See detailChirurgie bariatrique chez le patient diabétique de type 1 : résultats d’une expérience limitée.
FRANCK, Marie ULg; DE FLINES, Jenny ULg; PAQUOT, Nicolas ULg et al

in Diabète & Métabolisme (2013), 39(suppl), 102

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See detailNutrition and bone health : turning beliefs into knowledge for healthy behaviour
Brandi, ML; Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 388-389

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See detailAltered cartilage phenotype in mice lacking Sirt-1 gene
Gabay, Odile; Zaal, K; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2013), 21

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See detailOn the Number of Abelian Bordered Words
Rampersad, Narad; Rigo, Michel ULg; Salimov, Pavel ULg

in Lecture Notes in Computer Science (2013), 7907

In the literature, many bijections between (labeled) Motzkin paths and various other combinatorial objects are studied. We consider abelian (un)bordered words and show the connection with irreducible ... [more ▼]

In the literature, many bijections between (labeled) Motzkin paths and various other combinatorial objects are studied. We consider abelian (un)bordered words and show the connection with irreducible symmetric Motzkin paths and paths in Z not returning to the origin. This study can be extended to abelian unbordered words over an arbitrary alphabet and we derive expressions to compute the number of these words. In particular, over a 3-letter alphabet, the connection with paths in the triangular lattice is made. Finally, we study the lengths of the abelian unbordered factors occurring in the Thue--Morse word. [less ▲]

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See detailHerbaceous Plant Availability and Use by Western Lowland Gorillas in South East Cameroon
Willie, Jacob; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailGenetic analysis of pig survival in a crossbred population
Dufrasne, Marie ULg; Misztal, Ignacy; Tsuruta, Shogo et al

in Journal of Animal Science (2013), 91(E-Suppl.2), 193

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See detailStrunian Rugose and Tabulate corals from Northwestern Turkey
Denayer, Julien ULg

in Document de l'Institut Scientifique, Rabat (2013), 26

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See detailGenetic analysis of longitudinal measurements of feed intake in Piétrain sire lines
Dufrasne, Marie ULg; Jaspart, Véronique; Wavreille, José et al

in Journal of Animal Science (2013), 91(E-Suppl.2), 293

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women
Reginster, Jean-Yves ULg; Ellis, AG; Luo, X et al

in Osteoporosis International (2013), 24(1), 37

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See detailSimultaneous fitting of statistical-model parameters to symmetric and asymmetric fission cross sections
Mancusi, Davide; Charity, R.J; Cugnon, Joseph ULg

in Journal of Physics: Conference Series (2013), 420

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See detailEffect of abrupt preload reduction on left atrial and ventricular pressures in a multi-scale mathematical model of the cardiovascular system
Pironet, Antoine ULg; Dauby, Pierre ULg; Kosta, Sarah ULg et al

in European Heart Journal Supplements : Journal of the European Society of Cardiology (2013), 34

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See detailImage-guided failure assessment of human trabecular bone - Inverse finite element modelling for characterization of elastic properties
Zwahlen, Alexander; Christen, David; Ruffoni, Davide ULg et al

in BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK (2013), 58(1),

Local interpretation of micro finite element (mu FE) simulations has become important in different fields of bone biomechanics. Although on an apparent level mu FE has successfully been validated against ... [more ▼]

Local interpretation of micro finite element (mu FE) simulations has become important in different fields of bone biomechanics. Although on an apparent level mu FE has successfully been validated against experiments, local validations are sparse and limited by imaging resolution. At the tissue level heterogeneity of Young's modulus has been reported. Although non-uniform material distribution have been shown to only have a minor influence on the apparent material properties, its impact on local material behaviour is largely unknown. By combining image-guided failure assessment (IGFA) using synchrotron-based-micro-computed tomography, strain mapping and inverse mu FE modelling, we present an experimental and computational framework which will allow studying local effects of intratrabecular heterogeneity of the Young's modulus. [less ▲]

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See detailDetecting correlated di-hadron pairs: about the extraction of transversity and beyond
Radici, Marco; Bacchetta, Alessandro; Courtoy, Aurore ULg

in World Scientific (2013)

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Journal of Psychophysiology (2013), 27(Suppl 1), 48

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See detailSpectral Modelling of Massive Binary Systems: The Example of LZ Cep
Palate, Matthieu ULg; Rauw, Grégor ULg; Mahy, Laurent ULg

in Central European astrophysical bulletin (2013)

Despite their importance for many astrophysical processes, massive stars are still not fully understood. Massive binaries offer an attractive way to improve our knowledge of the fundamental properties of ... [more ▼]

Despite their importance for many astrophysical processes, massive stars are still not fully understood. Massive binaries offer an attractive way to improve our knowledge of the fundamental properties of these objects. However, some secondary effects are known to generate variations in the spectra of massive binaries, rendering their analyses more difficult. We present here a new approach to the computation of synthetic spectra of massive binaries at different phases of their orbital cycle. Our model starts with the Roche potential modified by radiation pressure and accounts for the influence of the companion star on the shape and physical properties of the stellar surface. We further account for gravity darkening and reflection effects to compute the surface temperature. Once the local gravity and temperature are determined, we interpolate in a grid of NLTE plan-parallel atmosphere model spectra to obtain the local contribution to the spectrum at each surface points. Then we sum all the contributions, accounting for the Doppler shift, and limb-darkening to obtain the total spectrum. The computation is repeated for different orbital phases and can be compared to the observations to determine the best parameters. We illustrate our method through the example of the LZ Cep system (O9III + ON9.7V). [less ▲]

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See detailThe Enhancement of Secondary Succession by Western Lowland Gorillas (Gorilla gorilla gorilla) in a Moist Tropical Forest of Southeast Cameroon
Petre, Charles-Albert ULg; Haurez, Barbara ULg; Tagg, Nikki et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailPrognostic value of FDG PET/CT in patients with lung tumors treated by Cyberknife.
LOVINFOSSE, Pierre ULg; JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg et al

in Journal of Nuclear Medicine (The) (2013), 54(SUPPL), 567

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See detailGenetics of body energy status of Holstein cows predicted by mid-infrared spectrometry
Bastin, Catherine ULg; Berry, D.; Gengler, Nicolas ULg et al

in Journal of Dairy Science (2013), 96(E-Suppl. 1),

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See detailIntraperitoneal Adhesions After Open or Laparoscopic Abdominal Procedure: An Experimental Study in the Rat.
Arung, Willy; Drion, Pierre ULg; Honoré, Pierre ULg et al

in Surgical Endoscopy (2013), 27

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See detailSystemic Active and Total Myeloperoxidase Levels in Coronary Artery Disease.
GACH, Olivier ULg; MAGNE, Julien ULg; Franck, Thierry ULg et al

in Cardiology (2013), 126(Suppl. 2), 1-521

Backgound: Measurement of total Myeloperoxidase (MPO) by ELISA is considered as a marker of neutrophil activation but is not the true indicator of the degree of its activity. In a dynamic pathology such ... [more ▼]

Backgound: Measurement of total Myeloperoxidase (MPO) by ELISA is considered as a marker of neutrophil activation but is not the true indicator of the degree of its activity. In a dynamic pathology such as atherosclerosis, it may be important to measure the real active part of MPO because it represents the true witness of the oxidant potential of the enzyme. Aim: To identify the relation between coronary artery disease identified by coronaro-angiography on measured serum total and active MPO levels and evaluate the correlation between these MPO levels and the presence of clinically defined unstable condition. Methods: Prospective analyse of serum samples of patients before (within 30 min) coronaro-angiography. Total and active MPO concentrations were assessed by sandwich Elisa and SIEFED® method’s respectively. Results: Two hundred and twenty patients were included in this study (age: 66.1±10.7 years, 67% of male). Among these, 62% presented significant coronary artery disease (stenosis more than 60% at least in one épicardial coronary artery). Twenty four patients (11%) presented unstable coronary syndrome. Mean active and total MPO in the general population were 50.1±63.5 and 147.6±223.3 ng.mL-1 respectively. In comparison, mean active MPO was 47.1±47.9 ng.mL-1 in stable patients and 75.1±135.2 ng.mL-1 in unstable patients (p=0.04). Mean total MPO was 146.3±224.7 ng.mL-1 in stable patients and 158.2±215.8 ng.mL-1 in the unstable’s one (p=0.8). There was a significant correlation between active MPO levels and instability (r=0.14, p=0.04) not present for total MPO levels (r=0.016, p=0.8). Conclusion: We observed a correlation between active MPO and clinical instability while there was no correlation with total MPO. Our preliminary results suggest that this marker could be a powerful indicator of instability which could possess an important prognostic impact. This hypothesis requires an evaluation in wider population and during a prolonged follow-up. [less ▲]

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See detailFeasibility and accessibility to the laparoscopic procedures in University Hospital of Kinshasa
Nsadi Fwene, Berthier; Veyi Tadulu, D.; Kazadi Mutshim, JM et al

in Surgical Endoscopy (2013), 27

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See detailQuantitative determination of non persistent endocrine disruptors in human urine
Dewalque, Lucas ULg; PIRARD, Catherine ULg; DUBOIS, Nathalie ULg et al

in Acta Clinica Belgica (2013), 68(6),

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See detailCorrelation between RNA and protein levels in a large european series from the LYSA
Bossard, C.; Dobay, M.P.; Lamant, L. et al

in Hematological Oncology (2013), 31 Suppl.1

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of ... [more ▼]

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of INO plus R-CVP in patients (pts) with relapsed/refractory CD22+ B-NHL. Efficacy data were also collected. Methods: Part 1 of this open-label study identified a maximum tolerated dose (MTD) of INO 0.8mg/m,2 on day 2 plus R-CVP (rituximab 375mg/m,2 cyclophosphamide 750mg/m,2 and vincristine 1.4mg/m,2 on day 1; prednisone 40mg/m,2 on days 1-5) every 21 days. Subsequently, pts were enrolled in the MTD confirmation cohort (part 2, n = 10), which required a dose-limiting toxicity rate of <33% in cycle 1 and <4 pts discontinuing prior to cycle 3 due to an adverse event (AE) in the MTD expansion cohort (part 3, n = 22), which explored preliminary activity. Results: Parts 2 and 3 enrolled 32 pts: 16 pts with diffuse large B-cell lymphoma, 15 with follicular lymphoma and one with mantle cell lymphoma. Median age was 64.5 years (range 44-81 years); 34% of pts had 1 prior regimen, 34% had 2, 28% had ≥3 and 3% had none (median 2; range 0-6).Median treatment duration was five cycles (range 1-6). Part 2 confirmed the MTD as standard dose R-CVP plus INO 0.8mg/m,2; 2/10 pts had a dose-limiting toxicity (grade 3 increased ALT/AST, grade 4 neutropenia requiring G-CSF). One pt discontinued because of an AE prior to cycle 3. Common treatment-related AEs were thrombocytopenia (78%), neutropenia (66%), fatigue (50%), leukopenia (50%), nausea (41%) and lymphopenia (38%); common grade 3/4 AEs were neutropenia (63%), thrombocytopenia (53%), leukopenia (38%) and lymphopenia (31%). There was one case of treatment-related fatal pneumonia with grade 4 neutropenia. Ten pts discontinued treatment due to AEs; thrombocytopenia/delayed platelet recovery was the leading cause (grade 1/2, n = 6; grade 3/4, n = 3). Objective response rate (ORR) was 77% (n = 24/31 evaluable pts), including 26% (n=8/31) with complete response (CR); three pts had stable disease. Of the pts with follicular lymphoma, ORR was 100% (n = 15/15), including seven pts with CR. Of the pts with diffuse large B-cell lymphoma, ORR was 60% (n = 9/16), including one pt with CR. Conclusions: Results suggest that INOplus R-CVP has acceptable toxicity and promising activity in relapsed/refractory CD22+ B-NHL. The most common grade 3/4 AEs were hematologic. Follow-up for progression-free and overall survival is ongoing. [less ▲]

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See detailProbing the phase of the elastic $pp$ scattering amplitude with vortex proton beams
Ivanov, Igor ULg

in AIP Conference Proceedings (2013)

We show that colliding vortex proton beams instead of (approximate) plane waves can lead to a direct measurement of how the overall phase of the scattering amplitude changes with the scattering angle. In ... [more ▼]

We show that colliding vortex proton beams instead of (approximate) plane waves can lead to a direct measurement of how the overall phase of the scattering amplitude changes with the scattering angle. In elastic $pp$ scattering, this will open a novel way to measure the parameter $\rho(t)$ and probe the real part of the Pomeron. [less ▲]

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See detailOptimizing scale search in species distribution models
Serckx, Adeline ULg; Huynen, Marie-Claude ULg; Beudels-Jamar, Roseline et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of ... [more ▼]

The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of global change. In many studies the influence of a predictor on a response derived over multiple and discrete spatial scales is evaluated. Due to inherent issue of multiple testing, this approach can be problematic. In this study on bonobos distribution, we suggest a 3-steps procedure that overcomes this problem. It takes into account the decay of a predictor by using a weighting function of distance to the observation of interest. We use variables to account for human pressure, food availability, patchy structure of the forest and nesting sites re-use. In a first step, we run a model with a fixed scale for every predictor based on expert opinion. For significant variables, we derive then in a second step the distance weighted influence over a range of scales. This helps to narrow down the search for the final model parameter estimates. Findings indicate that bonobo distribution is driven on the intermediate scale by forest patches structure. Food availability explains their abundance only at smaller scales. Those results demonstrate the sadly well-known influence of habitat fragmentation on animals’ density and distribution but also highlight the importance to understand influences of scale, the animal perceptions of their environment, by using appropriate statistical procedures. Our method can be particularly useful to formulate specific management hypotheses for conservation. Furthermore, its principles can be of use to other types of studies, such as behavior. [less ▲]

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See detailSpatial distribution of erosion and deposition on an agricultural watershed
Pineux, Nathalie ULg; Colinet, Gilles ULg; Degré, Aurore ULg

in Geophysical Research Abstracts (2013), 15

To better understand the agricultural landscapes evolution becomes an essential preoccupation and, for this, it is needed to take into account the sediments deposition, in a distributed way. As it is not ... [more ▼]

To better understand the agricultural landscapes evolution becomes an essential preoccupation and, for this, it is needed to take into account the sediments deposition, in a distributed way. As it is not possible in practice to study all terrestrial surfaces in detail by instrumenting sectors to obtain data, models of prediction are valuable tools to control the current problems, to predict the future tendencies and to provide a scientific base to the political decisions. In our case, a landscape evolution model is needed, which aims at representing both erosion and sedimentation and dynamically adjusts the landscape to erosion and deposition by modifying the initial digital elevation model. The Landsoil model (Landscape design for Soil conservation under soil use and climate change), among others, could fulfil this objective. It has the advantage to take the soil variability into account. This model, designed for the analysis of agricultural landscape, is suitable for simulations from parcel to catchment scale, is spatially distributed and event-based. Observed quantitative data are essential (notably to calibrate the model) but still limited. Particularly, we lack observations spatially distributed on the watershed. For this purpose, we choose a watershed in Belgium (Wallonia) which is a 124 ha agricultural zone in the loamy region. Its slopes range from 0% to 9%. To test the predictions of the model, comparisons will be done with: - sediment measurements which are done with water samplings in four points on the site to compare the net erosion results; - sediment selective measurements (depth variation observed along graduated bares placed on site) to compare the erosion and deposition results; - very accurate DSM’s (6,76 cm pixel resolution X-Y) obtained by the drone (Gatewing X100) each winter. Besides planning what the landscape evolution should be, a revision of the soil map (drew in 1958) is organized to compare with the past situation and establish how the landscape moved in 50 years. The first results of the sediment measurements and of the pictures of the drone will be showed in the presentation. [less ▲]

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See detailExperimental and numerical study of TA6V mechanical behavior under different quasi-static strain paths at room temperature
Gilles, Gaëtan ULg; Habraken, Anne ULg; Cazacu, Oana et al

in AIP Conference Proceedings (2013), 1532

This paper presents an experimental study of the quasi-static mechanical behavior of TA6V titanium alloy. Different monotonic tests were carried out in several orientations in the plane of the sheet in ... [more ▼]

This paper presents an experimental study of the quasi-static mechanical behavior of TA6V titanium alloy. Different monotonic tests were carried out in several orientations in the plane of the sheet in order to characterize the anisotropy and the tension-compression asymmetry exhibited by the material. Initial yielding is modeled by the phenomenological CPB06 criterion and Voce's isotropic hardening is used to describe its evolution. The simulation of a deep-drawing process is performed using the proposed constitutive modeling and compared with experimental data. [less ▲]

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See detailPhysico-chemical and membrane-interacting properties of D-xylose-based bolaforms. Influence of the anomeric configuration
Nasir, Mehmet Nail ULg; Legrand, Vincent; Gatard, Sylvain et al

in MATEC Web of Conferences (2013), 4

Sugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the ... [more ▼]

Sugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the pharmaceutical and cosmetic fields. Until now, no detailed analyses of the physico-chemical properties of these compounds have been undertaken. Two symmetrical D-xylose-based bolaforms were chemically synthesized where the two xylose heads are linked via an acetal link to a hydrocarbon chain containing 18 carbon atoms and an unsaturation. The two bolaforms differ only by their anomeric configuration: or The bolaform exhibits interfacial properties at the air-water interface which is not the case for the . FTIR spectroscopy showed that the interactions between the bolaform and POPC, a model phospholipid, involve the carbonyl groups of the phospholipid [less ▲]

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See detailAnother Generalization of Abelian Equivalence: Binomial Complexity of Infinite Words
Rigo, Michel ULg; Salimov, Pavel ULg

in Lecture Notes in Computer Science (2013), 8079

The binomial coefficient of two words u and v is the number of times v occurs as a subsequence of u. Based on this classical notion, we introduce the m-binomial equivalence of two words refining the ... [more ▼]

The binomial coefficient of two words u and v is the number of times v occurs as a subsequence of u. Based on this classical notion, we introduce the m-binomial equivalence of two words refining the abelian equivalence. The m-binomial complexity of an infinite word x maps an integer n to the number of m-binomial equivalence classes of factors of length n occurring in x. We study the first properties of m-binomial equivalence. We compute the m-binomial complexity of the Sturmian words and of the Thue-Morse word. We also mention the possible avoidance of 2-binomial squares. [less ▲]

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See detailGestion de la reproduction dans les troupeaux bovins laitier
Hanzen, Christian ULg; Rao, Anne-Sophie ULg; Theron, Léonard ULg

in Revue Africaine de Santé et de Productions Animales [=RASPA] (2013)

La décision de la commission européenne de mettre fin en 2015 à la politique des quotas laitiers mise en place en 1984 va vraisemblablement bousculer le paysage laitier européen mais aussi mondial. Plus ... [more ▼]

La décision de la commission européenne de mettre fin en 2015 à la politique des quotas laitiers mise en place en 1984 va vraisemblablement bousculer le paysage laitier européen mais aussi mondial. Plus que jamais les grands pays producteurs (Etats-Unis, Canada, France, Allemagne, Pays-Bas, Irlande, Nouvelle-Zélande) vont dans ce contexte de libéralisation et de globalisation de « l’or blanc » se livrer une concurrence effrénée dans laquelle la majorité des producteurs n’auront que peu ou rien à dire. L’augmentation attendue de la production laitière mondiale (15 milliards de litres par an entre 2010 et 2020) résulte bien entendu de l’augmentation de la population mondiale (3,1 milliards entre 1970 et 2010 auxquels s’ajouteront 2 milliards de plus en 2050) mais également du fait que davantage de personnes en Extrême et Moyen-Orient, en Amérique du Sud et en Afrique du Nord consomment davantage de lait et de produits dérivés. L’enjeu pour la majorité des éleveurs européens ou non va être de réduire les coûts liés à la production laitière en (1) optimisant les ressources alimentaires, (2) en améliorant la santé mammaire, (3) en augmentant la longévité des vaches, (4) en réduisant la fréquence des maladies métaboliques, locomotrices ou infectieuses et (5) en améliorant la fécondité. L’amélioration de la fécondité passe définition oblige par la réduction de l’âge du premier vêlage et de l’intervalle entre vêlages. Par gestion, il faut entendre dans un premier temps la quantification du problème et dans un second l’identification des diverses hypothèses diagnostiques qui en sont responsables. Les facteurs de nature alimentaire, thérapeutique, pathologique ou de gestion susceptibles de modifier l'évolution normale de chaque femelle depuis sa naissance jusqu'au moment de sa réforme sont de nature diverse. Ils concernent l'individu ou le troupeau. Ils sont directement ou indirectement responsables de leur fertilité et/ou de leur fécondité. Leurs effets se manifestent de manière isolée ou synergique. Ils concernent aussi bien les animaux que ceux qui en ont la responsabilité sanitaire ou de gestion. Ils sont de nature anatomique, infectieuse, hormonale, thérapeutique ou zootechnique. Par gestion de la reproduction, il faut entendre une approche épidémiologique, globale de l’infécondité qui en intègre les aspects spécifiques sans négliger pour autant les autres aspects qui ne lui sont pas directement liés. Par gestion de la reproduction, on peut aussi comprendre sa gestion hormonale à savoir le recours à des protocoles thérapeutiques de synchronisation des inséminations et donc des vêlages. L’une et l’autre approche s’inscrive dans le contexte d’une identification systématique des animaux à risque au travers d’un suivi mensuel de reproduction. Ce suivi est la clé de voûte d’une gestion de la reproduction. Au travers d’une démarche hypothético-déductive, la présente communication se propose de - quantifier les performances de reproduction au travers des ses principaux paramètres de fécondité et de fertilité : cette première étape est indispensable pour identifier la présence ou non d’un problème d’infécondité, - passer en revue et de manière aussi synthétique que possible les diverses hypothèses et donc les facteurs de risque responsables d’infécondité - proposer des stratégies curatives ou préventives, anti-infectieuses ou hormonales voire zootechniques pour limiter les conséquences de l’infécondité. [less ▲]

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See detailSecond harmonic generation from tyrosine containing peptides
Nasir, Mehmet Nail ULg; Bergmann, Emeric; Benichou, Emmanuel et al

in Proceedings of SPIE (2013), 8817

The Second Harmonic Generation (SHG) response from Tyrosine-containing peptides at the air-water interface is presented. First, the quadratic hyperpolarizability of the aromatic amino acid Tyrosine ... [more ▼]

The Second Harmonic Generation (SHG) response from Tyrosine-containing peptides at the air-water interface is presented. First, the quadratic hyperpolarizability of the aromatic amino acid Tyrosine obtained by Hyper Rayleigh Scattering is reported, demonstrating its potentiality as an endogenous molecular probe for SHG studies. Then, the single Tyrosine antimicrobial peptide Mycosubtilin is monitored at the air-water interface and compared to another peptide, Surfactin, lacking a Tyrosine residue. Adsorption kinetics and polarization analysis of the SHG intensity for the peptide monolayers clearly demonstrate that the SHG response from Mycosubtilin arises from Tyrosine. Besides, it confirms that indeed Tyrosine can be targeted as an endogenous molecular probe. [less ▲]

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See detailDe la Paix d'Angleur (1313) au sac de Liège (1468). Aspects des luttes socio-politiques à Liège aux XIVe et XVe siècles
Xhayet, Geneviève ULg

in Bulletin de la Société d'Art et d'Histoire du Diocèse de Liège (2013), LXX

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See detailExtension of the Liège Intra Nuclear Cascade model to light ion-induced collisions for medical and space applications
Leray, S.; Mancusi, D.; Kaitaniemi, P. et al

in Journal of Physics: Conference Series (2013), 420

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See detailDéveloppement et validation de la version française d'un questionnaire traitant des attentes des patients dans l'arthrose des membres inférieurs
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Revue du Rhumatisme (2013), 80(S1), 181

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See detailDeciphering the role of 75KDA SIRT1 fragment in osteoarthritis
Dvir-Ginzberg, M; Oppenheimer, H; Meir, H et al

in Osteoarthritis and Cartilage (2013), 21

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See detailPreliminary data on plicathyridines (Brachiopoda) from the Frasnian of southern Belgium and the Middle East (Afghanistan, Iran)
Mottequin, Bernard ULg; Marion, Jean-Marc ULg; Brice, Denise

in Documents de l’Institut Scientifique (Rabat) (2013), 26

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See detailInteraction of fengycin with stratum corneum mimicking model membranes: a calorimetry study
Nasir, Mehmet Nail ULg; Eeman, Marc; Olofsson, Gerd et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 168

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See detailLe ranélate de strontium diminue la proportion de patients progressant rapidement dès la première année : une analyse post hoc de l'étude SEKOIA
Chevalier, X; Richette, P; Bruyère, Olivier ULg et al

in Revue du Rhumatisme (2013), 80(S1), 59-60

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See detailRisk factors for atrial fibrillation and ventricular tachyarrhythmias in 3499 equids admitted at the liege university equine hospital between 1994 and 2011
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Proceedings of the 2013 ECEIM Congress (2013)

Risk factors for atrial fibrillation (AF) and pathological ventricular tachyarrhythmias (VTA) have been suspected in equids, however little epidemiologic data exists. The aim of this study was to ... [more ▼]

Risk factors for atrial fibrillation (AF) and pathological ventricular tachyarrhythmias (VTA) have been suspected in equids, however little epidemiologic data exists. The aim of this study was to determine risk factors for AF and VTA in a large equine population. Case files of 3499 equids admitted to the internal medicine department of the Liege University Equine Teaching Hospital between 1994 and 2011were reviewed. Amongst them, 495 horses with a suspicion of a cardiac abnormality underwent ECG and echocardiography. After calculation of prevalence of AF and VTA, we tested whether breed (chi-square test) or gender, age, body weight (BW) and presence of other cardiac diseases (logistic regressions) were risk factors (significance set at p<0.05). In the studied population, prevalence of AF was high (2.3%), whereas prevalence of VTA was low (0.7%). Warmbloods and standardbreds were significantly overrepresented in AF cases. High BW was a risk factor for AF (OR=3.54; CI=1.67-7.49), whereas age was not. No effect of breed, age or BW was demonstrated for VTA. AF was observed significantly more frequently in horses presenting with moderate to severe mitral regurgitation (MR), tricuspid regurgitation, and pulmonary regurgitation, and VTA was significantly more frequent in horses with MR. Several previously suspected but not statistically demonstrated risk factors of AF were confirmed in this study and horses presenting valvular disease could be at increased risk of developing AF and VTA. [less ▲]

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See detailComparison of Immune Reconstitution after Hematopoietic Stem Cell Transplantation with Flu-TBI versus TLI-ATG Conditioning
Hannon, Muriel ULg; Humblet-Baron, S.; Graux, C. et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 38

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See detailPrevalence of vitamin D inadequacy in European postmenopausal women aged over 80 years
Bruyère, Olivier ULg; Slomian, Justine ULg; Beaudart, Charlotte ULg et al

in European Geriatric Medicine (2013), 4(S1), 13-14

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See detailSterile neutrinos and $R_K$
Vicente, Avelino ULg

in Journal of Physics: Conference Series (2013), 447

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See detailFirst steps towards an explicit modeling of aba production and translocation in relation with the water uptake dynamics
Lobet, Guillaume ULg; Pagès, Loic; Draye, Xavier

in Acta Horticulturae (2013), 991

Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act ... [more ▼]

Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act as a switch in the water flow, even under high transpiration demand. The control of the stomatal aperture by the plant has been the object of numerous research projects since decades and different models have been developed to study stomatal regulation. The plant hormone abscisic acid (ABA) produced in the leaves acts as an endogenous signal triggering stomatal closure, but is also thought to act as a long distance signal that is produced by roots experiencing water deficit. However, the relative contributions of leaf-supplied ABA, root-supplied ABA and xylem water potential in the regulation of water flow remains a matter of controversy. Using a novel functional structural plant model (PlaNet-Maize-ABA), we report here a first attempt to explicitly simulate ABA production, degradation, translocation in all plant organs and their effect on the transpiration flow. [less ▲]

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See detailLa consommation d’oleuropéine ou de rutine diminue le développement spontané de l’arthrose chez le cobaye Hartley
Sanchez, Christelle ULg; Horcajada, Marie-Noëlle; Membrez, Fanny et al

in Revue du Rhumatisme (2013), 80S

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See detailInhibition de la sclérostine par le romosozumab chez des femmes ménopausées ayant une DMO basse : résultats de l'étude de phase 2
Brown, JP; McClung, MR; Grauer, A et al

in Revue du Rhumatisme (2013), 80(S1), 73

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See detailA new method for computing the derivatives of the mean and amplitude of physiological variables with respect to the parameters of a cardiovascular system model
Pironet, Antoine ULg; Dauby, Pierre ULg; Revie, James A. et al

in Minimally Invasive Therapy & Allied technologies : Official Journal of the Society for Minimally Invasive Therapy (2013), 22

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See detailInfusion of CliniMACS (Myltenyi Biotec) Enriched Regulatory T Cells Delays Experimental Xenogeneic Graft-versus-Host Disease
Hannon, Muriel ULg; Lechanteur, C.; Somja, Joan ULg et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 15

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See detailImproving the Accuracy of Monitoring Great Apes in the Wild: A Case Study from Southeast Cameroon
Tagg, Nikki; Willie, Jacob; Petre, Charles-Albert ULg

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailVisean corals from the transverse Jebel Begaa to Gara el Itima (eastern Tafilalt, Morocco)
Aretz, Markus; Denayer, Julien ULg

in Document de l'Institut Scientifique, Rabat (2013), 26

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See detailSymmetries in multi-Higgs-doublet models
Ivanov, Igor ULg; Vdovin, Evgeny

in AIP Conference Proceedings (2013)

We report the recent progress in understanding of symmetries which can be implemented in the scalar sector of electroweak symmetry breaking models with several Higgs doublets. In particular we present the ... [more ▼]

We report the recent progress in understanding of symmetries which can be implemented in the scalar sector of electroweak symmetry breaking models with several Higgs doublets. In particular we present the list of finite reparametrization symmetry groups which can appear in the three-Higgs-doublet models. [less ▲]

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See detailIn silico simulations of bone remodeling with improved parameter estimation from local strains and dynamic morphometry in vivo
Levchuk, Alina; Sommer, Remo; Badilatti, Sandro D. et al

in JOURNAL OF BONE AND MINERAL RESEARCH (2013), 28(1),

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See detailOn differentially dissipative dynamical systems
Forni, Fulvio ULg; Sepulchre, Rodolphe ULg

in IFAC-PapersOnLine website. (2013)

Dissipativity is an essential concept of systems theory. The paper provides an extension of dissipativity, named differential dissipativity, by lifting storage functions and supply rates to the tangent ... [more ▼]

Dissipativity is an essential concept of systems theory. The paper provides an extension of dissipativity, named differential dissipativity, by lifting storage functions and supply rates to the tangent bundle. Differential dissipativity is connected to incremental stability in the same way as dissipativity is connected to stability. It leads to a natural formulation of differential passivity when restricting to quadratic supply rates. The paper also shows that the interconnection of differentially passive systems is differentially passive, and provides preliminary examples of differentially passive electrical systems. [less ▲]

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See detailSurface and lipid interaction properties of novel rhamnolipids to explain their eliciting activity
Nasir, Mehmet Nail ULg; Monhonval, Pierre; Nott, Katherine ULg et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 168

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See detailSNR dependence of mean kurtosis and how to correct it
André, Elodie ULg; Phillips, Christophe ULg; Farrher, Ezequiel et al

in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society For Magnetic Resonance in Medicine. Scientific Meeting and Exhibition (2013), 21

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See detailStudy of a solar concentrator for space based on a diffractive/refractive optical combination
Michel, Céline ULg; Loicq, Jerôme ULg; Languy, Fabian ULg et al

in AIP Conference Proceedings (2013), (1556), 97-100

This paper presents a new design of a planar solar concentrator for space applications focusing on two spatially separated PV cells, allowing independent control of output power of each cell. It has the ... [more ▼]

This paper presents a new design of a planar solar concentrator for space applications focusing on two spatially separated PV cells, allowing independent control of output power of each cell. It has the advantages of both spectral splitting and solar concentration by the combination of a blaze transmission diffraction grating and a flat cylindrical Fresnel lens. An optical optimization has been realized and two variations of configuration have been developed to improve tracking tolerance: first, a design completed by secondary reflective concentrators and second, a symmetrical configuration composed of two lenses. First numerical results are presented, highlighting the possibility to design a concentrator at about 10×, with an electrical output power about 290W/m² lens and less than 10% losses for tracking errors lower than ±0.9°. [less ▲]

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See detailPartonic Picture of Generalized Transverse Momentum Distributions
Liuti, Simonetta; Courtoy, Aurore ULg; Goldstein, Gary R. et al

in World Scientific (2013)

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See detailRisks factors for valvular regurgitations in 3499 equids: a cross-sectional study.
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Proceedings of the 2013 ACVIM Forum (2013)

Risk factors for valvular regurgitations (VR) have been suspected in equids, but no extensive epidemiologic study has been performed in a large mixed equine population. Therefore, the aim of this study ... [more ▼]

Risk factors for valvular regurgitations (VR) have been suspected in equids, but no extensive epidemiologic study has been performed in a large mixed equine population. Therefore, the aim of this study was to statistically test risk factors for VR in a large population of equids. Hospital records were reviewed for 3.499 equids, admitted at the internal medicine department of the Liege Equine Teaching Hospital between 1994 and 2011, aged ≥2 years, and which underwent thorough cardiac clinical evaluation. Of this population, 495 cases had ECG and echocardiography performed because of a clinical suspicion of cardiac disease. Chi-square test or logistic regressions (as appropriate) were used to test if breed, gender, age, body weight (BW), and co-existence of various cardiac diseases were risk factors for each VR. Moreover, the risk of development of congestive heart failure (CHF) was tested for each VR. Significance was set at p<0.05. Most of the studied animals were warmbloods, and observed prevalences were 4.4% for mitral regurgitation (MR), 2.1% for aortic regurgitation (AR), 1.7% for tricuspid regurgitation (TR), and 1.0% for pulmonary regurgitation (PR). Significant risk factors were male gender and increasing age for AR (OR=2.03, CI=1.07-4.94), and racehorses breed group and middle-age for TR (OR=4.36; CI=1.10-17.24). No effect of age or BW was demonstrated for MR. MR was the major valvular disease associated with atrial fibrillation (AF), ventricular tachyarrhythmia, PR and CHF. TR was also linked to AF, PR and CHF; but AR was not linked to CHF. In conclusion, several previously suspected risks factors for VR were confirmed statistically in this study and should be taken into account in health and athletic monitoring of horses presenting predisposing factors. [less ▲]

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