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See detailAgeism among nurses in oncology
Schroyen, Sarah ULiege; Missotten, Pierre ULiege; Jerusalem, Guy ULiege et al

in International Psychogeriatrics (2016)

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See detailCircadian and homeostatic sleep pressure modulate fMRI correlates of vigilant attention
Muto, Vincenzo ULiege; Jaspar, Mathieu ULiege; Meyer, C et al

in Journal of Sleep Research (2016), 25(s1),

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See detailAvelumab (MSB0010718C ; anti-PD-L1) as a first-line treatment for patients with advanced NSCLC from the JAVELIN Solid Tumor phase 1b trial : safety, clinical activity, and PD-L1 expression
Verschraegen, C.; Chen, F.L.; Spigel, D.R. et al

in Journal of Clinical Oncology (2016), 34

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See detailBrain-derived neurotrophic factor (BDNF) in normal healthy and hemodialyzed populations
CAVALIER, Etienne ULiege; Carlisi, A.S.; WATAR, Florence ULiege et al

in Journal of Frailty & Aging (2016), 5(Supplement 1), 116

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See detailImplementation of the green payment within the scheme of the new Common Agricultural Policy (2015-2020): first results for 2015 in Wallonia (South of Belgium)
Burny, Philippe ULiege; Terrones Gavira, François ULiege

in Quality-Access to Success (2016), (Supplement), 10-14

At the end of 2013, a new Common Agricultural Policy was defined at the European level, including the implementation of the so-called “green payment”, which obliges farmers to respect three new conditions ... [more ▼]

At the end of 2013, a new Common Agricultural Policy was defined at the European level, including the implementation of the so-called “green payment”, which obliges farmers to respect three new conditions in order to get financial support through direct payments. The year 2015 being the first implementation year, the consequences on Walloon agriculture are examined. It appears that 50% of Walloon farmers are not obliged to practice crop diversification, while 16% are obliged to have at least two crops on their arable land and 33% are obliged to have at least three crops on their arable land. Less than 1% does not respect the new diversification rules. Concerning the obligation to have at least 5% of ecological focus area on the arable land, it appears that 54% of Walloon farmers are in conditions not to be obliged to respect the measure. When they implement the measure, the percentage of ecological focus areas in arable land reaches 6.9% as a mean and 2.4% do not reach the requested 5%. Finally, it can be said that the green payment does not represent a big constraint for Walloon farmers, though eventual economic consequences are still to be precised, while environmental benefits are strengthened. [less ▲]

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See detailPrevalence of concomitant bone and muscle wasting in patients from the SarcoPhAge Study
Locquet, Médéa ULiege; Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege et al

in Journal of Frailty & Aging (2016), 5(Supplement 1), 84

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See detailInfluence of crossed fields in structures combining large grain, bulk (RE)BCO superconductors and soft ferromagnetic discs
Philippe, Matthieu ULiege; Fagnard, Jean-François ULiege; Wera, Laurent ULiege et al

in Journal of Physics: Conference Series (2016), 695

Bulk (RE)BCO superconductors are able to trap record magnetic fields and can be used as powerful permanent magnets in various engineering applications such as rotating machines and magnetic bearings. When ... [more ▼]

Bulk (RE)BCO superconductors are able to trap record magnetic fields and can be used as powerful permanent magnets in various engineering applications such as rotating machines and magnetic bearings. When such superconducting (SC) “trapped field magnets” are combined to a ferromagnetic (FM) disc, the total magnetic moment is increased with respect to that of the superconductor alone. In the present work, we study experimentally the magnetic behaviour of such hybrid FM/SC structures when they are subjected to cycles of applied field that are orthogonal to their permanent magnetization, i.e. a “crossed-field” configuration. Experimental results show that the usual “crossed-field demagnetization” caused by the cycles of transverse field is strongly reduced in the presence of the ferromagnet. [less ▲]

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See detailCalibration of MATSim in the context of natural hazards in Liège (Belgium): Preliminary results
Saadi, Ismaïl ULiege; El Saeid Mustafa, Ahmed Mohamed ULiege; Teller, Jacques ULiege et al

in Proceedings of the 12th Conference on Transport Engineering (2016)

In Belgium, river floods are among the most frequent natural disasters and they may cause important changes on travel demand. In this regard, we propose to set up a large scale scenario using MATSim for ... [more ▼]

In Belgium, river floods are among the most frequent natural disasters and they may cause important changes on travel demand. In this regard, we propose to set up a large scale scenario using MATSim for guarantying an accurate assessment of the river floods impact on the transportation systems. In terms of inputs, agent-based models require a base year population. In this context, a synthetic population with a respective set of attributes is generated as a key input. Afterwards, agents are assigned activity chains through an activity-based generation process. Finally, the synthetic population and the transportation network are integrated into the dynamic traffic assignment simulator, i.e. MATSim. With respect to data, households travel surveys are the main inputs for synthesizing the populations. Besides, a steady-state inundation map is integrated within MATSim for simulating river floods. To our knowledge, very few studies have focused on how river floods affect transportation systems. In this regard, this research will undoubtedly provide new insights in term of methodology and traffic pattern analysis under disruptions, especially with regard to spatial scale effects. The results indicate that at the municipality level, it is possible to capture the effects of disruptions on travel behavior. In this context, further disaggregation is needed in future studies for identifying to what extent results are sensitive to disaggregation. In addition, results also suggest that the target sub-population exposed to flood risk should be isolated from the rest of the travel demand to reach have more sensitive effects. [less ▲]

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See detailPhage therapy against antimicrobial resistance, design of the first clinical study Phagoburn.
Jault, Patrick; Gabard, Jérôme; Leclerc, Thomas et al

in Critical Care (2016), 20(Suppl 2), 109

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See detailExergy analysis applied to performance of buildings in Europe
Sartor, Kevin ULiege; Dewallef, Pierre ULiege

in Proceedings (2016)

Energy performance of buildings generally assesses the energy consumption of buildings such as heating, domestic heat water, ventilation systems... However, this approach is based on the first law of ... [more ▼]

Energy performance of buildings generally assesses the energy consumption of buildings such as heating, domestic heat water, ventilation systems... However, this approach is based on the first law of thermodynamics and considers only the quantity of energy used without considering its “quality” and leads to a lack of information about the energy conversion processes. This is particularly true in the new low-energy buildings where sometimes high temperatures sources are used to meet low-temperature needs. The exergy analysis of a system, based on first and second thermodynamic laws, can be used to overcome this. In this work, it is proposed to compare the energy and the exergy consumption of several kinds of buildings to determine the best systems in terms of energy and exergy needs. The energy demand calculations are performed using the official software available in Belgium and some assumptions are implemented to consider the exergy approach. As exergy calculations require a reference state, some different climatic conditions are also investigated. Finally, some conclusions are discussed to rank the sources of energy and their related exergy losses. [less ▲]

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See detailPurpura thrombocytopénique idiopathique...idiopathique, vraiment?
LONGTON, Julie ULiege; DRESSE, Marie-Françoise ULiege; Florkin, Benoît et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2016), 18(1), 112

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See detailFramework for building integrated policies regarding forest risk management: Insights from Wallonia (Belgium)
Riguelle, Simon ULiege

in Natural Resources and Bioeconomy Studies (2016), 41

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See detailAntonymic co-presence: overview of the syntactic patterns model
Steffens, Marie ULiege

in Studies van de BKL - Travaux du CBL - Papers of the LSB (2016), 10

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See detailPharmacokinetic (PK) effects and safety of olaparib in combination with tamoxifen, anastrozole or letrozole : Phase I study
Plummer, R.; Verheul, H.M.; Langenberg, M. et al

in Journal of Clinical Oncology (2016), 34

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See detailadministration of Third-Party Mesenchymal Stromal Cells at the Time of Kidney Transplantation: Interim Safety Analysis at One-Year Follow-Up
WEEKERS, Laurent ULiege; Erpicum, Pauline ULiege; DETRY, Olivier ULiege et al

in Transplant International (2016), 29(Suppl 2), 13-6

Objective. Mesenchymal stromal cells (MSC) therapy has been suggested in kidney transplantation (KTx). We report on the 1-year follow-up of an open-label phase I trial using MSC at the time of KTx ... [more ▼]

Objective. Mesenchymal stromal cells (MSC) therapy has been suggested in kidney transplantation (KTx). We report on the 1-year follow-up of an open-label phase I trial using MSC at the time of KTx. Methods. On postoperative day 3 (D3), third-party MSC (~2.0x106/kg) were administered to 7 non-immunized first-transplant recipients from deceased donors, under standard immunosuppression (Basiliximab, Tacrolimus, MMF and steroids). No HLA matching was required for MSC donors. In parallel, 7 comparable KTx recipients were included as controls. Written informed consent was obtained from all participants. Results. No hemodynamic or immune-allergic side-effect was noted at the time of MSC injection. Still, 1 patient with a history of ischemic heart disease had a NSTEMI ~3h after MSC infusion. Four MSC patients presented with CMV reactivation within 165 ± 96 days post KTx, whereas 3 controls had positive polyoma-BK viremia within 92 ± 4d post KTx. Three MSC patients were affected by pneumonia within 269 ± 98d post KTx, whereas 3 controls had urinary infection within 48 ± 43d post KTx. No MSC engraftment syndrome was observed. At D14, eGFR in MSC and control groups was 47.1 ± 6.8 and 39.7 ± 5.9 ml/min, respectively (p, 0.05). At 1 year, eGFR in MSC and control groups was 43.1 ± 17.8 and 53.9 ± 13.4 ml/min, respectively (p, 0.25). At 3-month protocol biopsy, no rejection was evidenced in MSC or control patients. Later on, 1 acute rejection was diagnosed at D330 in 1 MSC patient. No biopsy-proven AR was noted in controls. Three patients developed anti-HLA antibodies against MSC (n=1) or shared kidney/MSC (n=2) mismatches. Conclusions. MSC infusion was safe in all patients except one. Incidence of opportunist and non-opportunist infections was similar in both MSC and control groups. No MSC engraftment syndrome was documented. No difference in eGFR was found at 1 year post KTx. Putative immunization against MSC was observed in 3 patients. [less ▲]

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See detailDiffusion MRI for following tumor modifications after neoadjuvant radiotherapy.
LALLEMAND, François ULiege; Leroi, Natacha ULiege; Bahri, Mohamed Ali ULiege et al

in Radiotherapy & Oncology (2016), 119

Neoadjuvant radiotherapy (NeoRT) improves tumor local control and tumor resection in many cancers. The timing between the end of the NeoRT and surgery is driven by the occurrence of side effects or the ... [more ▼]

Neoadjuvant radiotherapy (NeoRT) improves tumor local control and tumor resection in many cancers. The timing between the end of the NeoRT and surgery is driven by the occurrence of side effects or the tumor downsizing. Some studies demonstrated that the timing of surgery and the RT schedule could influence tumor dissemination and subsequently patient overall survival. We demonstrated the impact of NeoRT on metastatic spreading in a Scid mice model. After an irradiation of 2x5gy, we show more metastasis in the lung when the mice are operated at day 4 compared to day 11. Here, our aim is to evaluate with functional MRI (fMRI) the impact of the radiation treatment on the tumor microenvironment and subsequently to identify non-invasive markers helping to determine the best timing to perform surgery for avoiding tumor spreading. [less ▲]

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See detailTechnical diversity within the tanged-tool Gravettian: new results from Belgium
Touzé, Olivier ULiege; Flas, Damien; Pesesse, Damien

in Quaternary International (2016), http://dx.doi.org/10.1016/j.quaint.2015.11.034

Located at the interface between the Paris and the Rhine Basins and the more northern territories of Europe, Belgium contains several Gravettian occupations, both open-air and in caves. The available ... [more ▼]

Located at the interface between the Paris and the Rhine Basins and the more northern territories of Europe, Belgium contains several Gravettian occupations, both open-air and in caves. The available documentation is unfortunately limited by the earliness of the excavations conducted at most sites. Stratified records in karstic context, primarily excavated in the 19th century, are particularly affected by this situation. The analysis of Gravettian lithic technological behaviours can, however, rely on two open air sites excavated in the late 20th century which provide more rigorous data: Maisières-Canal and Station de l'Hermitage. These two sites have been the focus of comparisons that highlight their similarities, both in terms of the lithic industry and location. In fact, the former stands out for the presence of tanged tools, a typological marker which is usually associated with the Early Gravettian of Western Europe. In this article, we present a new study that evidences the differences in the lithic technical systems represented at these sites. After a presentation of the most recent data, we consider the causes that may be responsible for such diversity, highlighting the possible role of the chronological factor, but also of the existence of an original technical tradition in north-western Europe during the appearance and development of the Gravettian. [less ▲]

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See detailHistoire et expérience fondatrice dans Sein und Zeit
Zincq, Aurélien ULiege

in Bulletin d'Analyse Phénoménologique (2016)

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See detailAntonymie et exhaustivité
Steffens, Marie ULiege

in SHS Web of Conferences (2016), 27

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See detailConclusions des journées d’étude "Cher Monsieur Madrane"
Fierens, Jacques ULiege

in Journal du Droit des Jeunes (2016), 354

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See detailStudy of the Potential Zoonotic Transmission of Clostridium difficile in Belgian Cattle Farms.
Rodriguez Diaz, Cristina ULiege; Hakimi, Djalal-Eddine; Daube, Georges ULiege et al

in Journal of Food Protection (2016), 79(supplement A),

Introduction: Zoonoses are infectious that can be transmitted between animals and humans through direct contact, close proximity or the environment. Since domestic and food animals frequently test ... [more ▼]

Introduction: Zoonoses are infectious that can be transmitted between animals and humans through direct contact, close proximity or the environment. Since domestic and food animals frequently test positive for the bacterium, it seems plausible that C. difficile could be zoonotic. A former study showed that the prevalence in veal calf aged less than 6 months was 22% while in adult cattle population, it was 6,9 %. Purpose: This study aimed to determine the prevalence and the epidemiology of C. difficile in cattle farms and the possible spread of the bacterium among animals and farmers. Methods: A total of 176 faecal samples of cattle were collected from 5 different Belgian farms (south East Belgium), from November 2015 to February 2016. A stool sample of each farmer was also requested. Detection of C. difficile was performed by classical culture on C. difficile selective medium (cycloserine cefoxitin fructose cholate). Isolates were characterised by PCR-ribotyping and Genotype Cdiff test (Hain Lifescience), which allows the detection of all toxin genes, mutations in gyrA gene and the deletion in the regulator gene tcdC. Toxic activity was confirmed by a cytotoxic assay on MRC-5 cells. Results: C. difficile was detected in 14/178 (7.9%) animal samples. Isolates were grouped into five different types, including PCR-ribotype 015 (this ribotype is one the most encountered in hospitals in Belgium). The other types were UCL46A, UCL24*, UCL24, UCL33. All of them were identified as toxigenic by cytotoxicity assay and toxin genes profile. In contrast, none of the 5 farmers studied were positive for the bacterium. Significance: Results obtained indicate that PCR-ribotypes commonly isolated from hospitalised patients are also present in cattle, indicating an animal reservoir. However, a zoonotic transmission could be not demonstrated in this preliminary study. [less ▲]

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See detailSofosbuvir + simeprevir +/-ribavirin treatment is efficient in genotype 4 chronic hepatitis C patients: results of a large international cohort.
Moreno, C; Derbala, M; Nguyen-Khac, E et al

in Hepatology (Baltimore, Md.) (2016), 64(1), 1990

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See detailEnquêter sur les non-publics de la culture: quelle posture de recherche pour quel dispositif méthodologique?
Ghebaur, Cosmina ULiege

in Questions de Communication (2016)

Mes travaux portent sur les non-publics de la culture et leur fabrication institutionnelle, à savoir leur production par les institutions chargées de mettre en œuvre sur un territoire donné les politiques ... [more ▼]

Mes travaux portent sur les non-publics de la culture et leur fabrication institutionnelle, à savoir leur production par les institutions chargées de mettre en œuvre sur un territoire donné les politiques culturelles les concernant. Pour explorer cette question, je me place dans la perspective initiée en sociologie de l'art par Pascale Ancel et Alain Pessin (2004) et caractérisée par la remise en question de la frontière entre publics et non-publics. On peut, écrit Martine Azam (2004), être " à la fois " public et non-public s'agissant de deux objets culturels différents ou du même objet à des moments différents. L'objectif de cet article est d'expliciter les principaux choix méthodologiques que j'ai été amenée à faire en enquêtant, avec cette posture de recherche, sur une exposition photographique en extérieur organisée dans une ville de la banlieue parisienne. [less ▲]

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See detailSclérostine & insuffisance rénale: que nous apprennent les différents méthodes de dosage?
PAQUOT, Francois ULiege; BOUQUEGNEAU, Antoine ULiege; CAVALIER, Etienne ULiege et al

in Néphrologie & Thérapeutique (2016), 12(5), 374

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See detailAssociation between vertebral heart score measurement and overweight condition in dogs
François, Marion; Merveille, Anne-Christine ULiege; Mc Entee, Kathleen ULiege et al

in Veterinary Radiology & Ultrasound (2016)

Introduction Vertebral heart score (VHS) is used to assess heart size on thoracic radiographs. Association between VHS and overweight condition in dogs of different breeds is still unknown. The aim of ... [more ▼]

Introduction Vertebral heart score (VHS) is used to assess heart size on thoracic radiographs. Association between VHS and overweight condition in dogs of different breeds is still unknown. The aim of this study is to determine if VHS is influenced by overweight condition in dogs. The hypothesis is that VHS is influenced by BCS and T4 ratio. Methods Recruitment criteria for this retrospective study were the presence of a minimum of 2 thoracic radiographic views and a diagnosis of “normal echocardiographic examination” in medical records from 2013 to 2016. Body weight, BCS and breed were extracted. VHS and overweight condition were calculated. Dogs from breeds with a normal maximal VHS < 11 (group 1) and from breeds with a normal maximal VHS > 11 (group 2) were separated. Statistical analyses were performed using XLStat® software. Results Fifty-one dogs were included in the study. Body weight ranged from 3.7 to 44.8 kg and was not recorded in 2 dogs. These dogs were not excluded because of the BCS was recorded for these dogs. BCS ranged from 3 to 9. Thirteen dogs had a VHS value superior to the normal range and all of them had BCS ≥ 4. A weak positive correlation was found between BCS and T4 ratio (P ≤ 0.001, R2=0.4). There was a positive relationship between BCS and VHS (ANCOVA, P ≤ 0.003) for each group and between T4 ratio and VHS for each group (ANCOVA, P ≤ 0.001). Discussion/Conclusions This study confirms that the T4 ratio is correlated to BCS evaluated clinically. This ratio could be used to assess overweight condition on thoracic radiographs. VHS is influenced by BCS and the T4 ratio; therefore, VHS should be use with caution in overweighed dogs. [less ▲]

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See detailUrban infrastructure resilience to fire disaster: An overview
Gernay, Thomas ULiege; Selamet, Serdar; Tondini, Nicola et al

in Procedia Engineering (2016), 161C

Fire disasters are a serious threat to the functionality of the built environment, in particular in densely populated urban areas where city infrastructure systems are under strain. Yet, fire safety ... [more ▼]

Fire disasters are a serious threat to the functionality of the built environment, in particular in densely populated urban areas where city infrastructure systems are under strain. Yet, fire safety issues are still mostly considered at the level of individual elements or buildings, disregarding the global risk for systems’ functionality. In line with the current efforts toward ensuring more resilient cities, this paper presents an overview of urban infrastructure resilience to fire disaster. The definitions of resilience and the quantitative frameworks established for other hazards such as earthquakes are reviewed. Then, the specificities of structural fire engineering are presented and it is shown how resilience frameworks could be applied to fire hazard. Finally, the paper identifies areas where further research efforts are needed. [less ▲]

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See detailThe effect of napping on the consolidation of explicit and implicit information
van Schalkwijk, F J; Heib, D P J; Hoedlmoser, K et al

in Journal of Sleep Research (2016), 25(s1),

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See detailEnd-to-end continuous manufacturing
Monbaliu, Jean-Christophe ULiege

in ChemistryViews (2016)

We will discuss the development and implementation of continuous-flow multistep strategies for the synthesis of high-value added organic targets. Selected examples include unusual reaction conditions such ... [more ▼]

We will discuss the development and implementation of continuous-flow multistep strategies for the synthesis of high-value added organic targets. Selected examples include unusual reaction conditions such as working with solids in microreactors, high temperature reactions and the handling of highly reactive species. [less ▲]

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See detailGeological evidence for Holocene earthquakes and tsunamis along the Nankai-Suruga Trough, Japan
Garett, Ed; Fujiwara, Osamu; Garrett, Philip et al

in Geophysical Research Abstracts (2016)

The Nankai-Suruga Trough, lying immediately south of Japan’s densely populated and highly industrialised southern coastline, generates devastating great earthquakes (magnitude > 8). Intense shaking ... [more ▼]

The Nankai-Suruga Trough, lying immediately south of Japan’s densely populated and highly industrialised southern coastline, generates devastating great earthquakes (magnitude > 8). Intense shaking, crustal deformation and tsunami generation accompany these ruptures. Forecasting the hazards associated with future earthquakes along this >700 km long fault requires a comprehensive understanding of past fault behaviour. While the region benefits from a long and detailed historical record, palaeoseismology has the potential to provide a longer-term perspective and additional insights. Here, we summarise the current state of knowledge regarding geological evidence for past earthquakes and tsunamis, incorporating literature originally published in both Japanese and English. This evidence comes from a wide variety of sources, including uplifted marine terraces and biota, marine and lacustrine turbidites, liquefaction features, subsided marshes and tsunami deposits in coastal lakes and lowlands. We enhance available results with new age modelling approaches. While publications describe proposed evidence from > 70 sites, only a limited number provide compelling, well-dated evidence. The best available records allow us to map the most likely rupture zones of eleven earthquakes occurring during the historical period. Our spatiotemporal compilation suggests the AD 1707 earthquake ruptured almost the full length of the subduction zone and that earthquakes in AD 1361 and 684 were predecessors of similar magnitude. Intervening earthquakes were of lesser magnitude, highlighting variability in rupture mode. Recurrence intervals for ruptures of the a single seismic segment range from less than 100 to more than 450 years during the historical period. Over longer timescales, palaeoseismic evidence suggests intervals ranging from 100 to 700 years. However, these figures reflect thresholds of evidence creation and preservation as well as genuine recurrence intervals. At present, we have not identified any geological data that support the occurrence earthquakes of larger magnitude than that experienced in AD 1707; however, few published studies seek to establish the relative magnitudes of different earthquake and tsunami events. Alongside the paucity of research designed to quantify the magnitude of past earthquakes, we emphasise a number of other issues, including alternative hypotheses for proposed palaeoseismic evidence, the lack of robust chronological frameworks and insufficient appreciation of changing thresholds of evidence creation and preservation over time. These key issues must be addressed by future research. [less ▲]

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See detailIdentification and characterization of volatile organic compounds active against barley pathogens
De Clerck, Caroline ULiege; Kaddes, Amine ULiege; Fiers, Marie et al

in Bulletin OILB/SROP = IOBC/WPRS Bulletin (2016), 117

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See detailLast millennium gravity reworking processes in the western Gulf of Corinth: correlations with historical seismicity and indication of earthquake clusters
Beckers, Arnaud; Beck, Christian; Hubert, Aurelia ULiege et al

in Geophysical Research Abstracts (2016), 18

The western tip of the Corinth Rift is considered as the most active within this major extensional structure, as evidenced by: seismicity, GPS kinematics, and INSAR data (Bernard et al., 2006). Within the ... [more ▼]

The western tip of the Corinth Rift is considered as the most active within this major extensional structure, as evidenced by: seismicity, GPS kinematics, and INSAR data (Bernard et al., 2006). Within the frame of a multidisciplinary project dedicated to seismic hazards assessment for this region, two offshore surveys - high resolution seismic reflection and gravity coring - were conducted in this area. They were dedicated to the Late Quaternary sedimentary fill as the latter was expected to record both long term deformation (Beckers et al., 2015) and sedimentary “events” related to major earthquakes and/or tsunamis. Seismic reflection imaging displays the time and geographical distributions of large submarine landslides (MTDs) during the last 100 kyr. Based on a morpho-sedimentary map and the active fault pattern, up to 2 m-long cores were selected to detect and characterise the possible impact of historical events. The chronological control is based on AMS 14C dating and four detailed 210Pb and 137Cs profiles. Sedimentation (components, sources, transport and settling mechanisms) was analysed through textural, chemical, and mineralogical parameters. Turbidites could be clearly separated from the hemipelagic deposits. Our attempt to correlate identified sedimentary “events” with historical data greatly benefited from a recently elaborated catalog (Albini et al., 2014) with precisely re-located epicentral areas. Cable breaks were also taken into account. Attenuation models (Papazachos & Papaioannou’s, 1997) were used to discuss paleo-intensities vs. distance form epicentral areas. From the whole set of cores, the following results may be underlined: - the correlations between cores from the different sites are not complete, including for a few neighbouring sites belonging to the same morpho-sedimentary unit; we relate these discrepancies to the complex bottom morphology and/or to bottom currents responsible for local erosion; - for several well-documented earthquakes and tsunamis, we could not find a clearly recorded sedimentary impact; - non earthquake-triggered MTDs (as the 1963 event) produced specific layers identical to the major earthquakes impacts. At the difference, for a few cores from the deep axial floor, several sandy or silty turbidites permit to establish correlations: i) between coring sites, ii) with earthquakes which stroke two different areas, respectively east and west of the concerned part of the Gulf. Furthermore, the sedimentary events show a particular time distribution for the last 600 yr: - two intervals with short recurrences: a recent one ( 1900 AD-Present or 1750 AD-Present) and an older one ( 1550 AD-1700 AD or 1450 AD-1800 AD); these time distributions differ from each coring site; - a long “quiet” period (150 to 200 yr). From these results, we tentatively consider this sedimentary record as an indicator of a migration of seismogenic faulting activity. Ref.: Albini, P., et al., 2014. Techn. Rep. I.N.G.V. Roma. Beckers, A., et al., 2015. Marine Geology, 360:55–69 Bernard, P., et al., 2006. Tectonophysics, 426:7-30. Papazachos, C., Papaioannou, C., 1997. Journal of Seismology, 1:181-201. [less ▲]

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See detailVolumetric brain MRI measurements in a retrospective Belgian multi-centr MRI biomarker study in dementia - REMEMBER
Niemantsverdriet; Smeets, D.; Bastin, Christine ULiege et al

in Acta Neurologica Belgica (2016)

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See detailCharacteristics and frequency of large submarine landslides at the western tip of the Gulf of Corinth
Beckers, Arnaud; Hubert, Aurelia ULiege; Beck, Christian et al

in Geophysical Research Abstracts (2016), 18

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See detailImpact of Age and Treatment Group in Childhood High Hyperdiploid Low Risk B-Cell Acute Lymphoblastic Leukemia (ALL): Results of the CLG-EORTC 58951 Study
Clement, Laura; Suciu, Stefan; Luquet, Isabelle et al

in Blood (2016)

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See detailGeomorphometric mapping of spatio-temporal changes in Plio-Quaternary uplift in the NW European Alpine foreland
Demoulin, Alain ULiege; Bourdon, Hadrien

in Geophysical Research Abstracts (2016), 18

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See detailA first database for landslide studies in densely urbanized areas of the intertropical zone: Abidjan, Côte d’Ivoire
Gnagne, Lorng Frédéric ULiege; Demoulin, Alain ULiege; Biemi, Jean et al

in Geophysical Research Abstracts (2016), 18

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See detailRole of inflammatory- and growth factors in the pathophysiology of gestational diabetes-related complications in neonates
Guffins, Amandine; FARHAT, Nesrine ULiege; GKIOUGKI, Evangelia ULiege et al

in Belgian Journal of Paediatrics (2016), 18(1), 82

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See detailPleading for a new DCB in the historical German deep facies of Sauerland near Stockum
Streel, Maurice ULiege; Korn, Dieter

in Subcommission on Devonian Stratigraphy Newsletter (2016), 31

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See detailUpdating the correlation Miospores/Conodonts in upper and uppermost Famennian
Streel, Maurice ULiege

in IUGS, Subcommisson Devonian Strata Newsletter (2016), 31

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See detailA no-go theorem for the dark matter interpretation of the positron anomaly
Laletin, Maxim ULiege

in Frascati Physics Series (2016), LXIII

The overabundance of high-energy cosmic positrons, observed by PAMELA and AMS-02, can be considered as the consequence of dark matter decays or annihilations. We show that recent FERMI/LAT measurements of ... [more ▼]

The overabundance of high-energy cosmic positrons, observed by PAMELA and AMS-02, can be considered as the consequence of dark matter decays or annihilations. We show that recent FERMI/LAT measurements of the isotropic diffuse gamma-ray background impose severe constraints on dark matter explanations and make them practically inconsistent. [less ▲]

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See detailGERONTECHNOLY IN WALLONIA
PETERMANS, Jean ULiege; LEJEUNE, CHRISTOPHE; MAERTENS, Fulvie ULiege et al

in Gerontechnology (2016), 15

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See detail'En fonction du futur': la fonction publique régionale wallonne sous contrainte d'innovation
Claisse, Frédéric ULiege; Guyot, Jean-Luc

in Prospective et Stratégie (2016), 1(7), 39-58

Building on a forward-looking reflexion initiated at the Walloon Institute for Evaluation, Foresight and Statistics (IWEPS), the paper considers the issues at stake for the transformation of the regional ... [more ▼]

Building on a forward-looking reflexion initiated at the Walloon Institute for Evaluation, Foresight and Statistics (IWEPS), the paper considers the issues at stake for the transformation of the regional Walloon public administration, taken as a changing environment under strong pressures – institutional, budgetary, demographic, economic and ideological –. In another perspective, these multiple constraints can also be seen as opportunities to innovate and to think about the public administration identity, modes of organisation and ways of performing its missions : how is the profession of civil servant going to be redefined, at a time when the proportion of contract employees vs. public servants has never been so high? What management practices can the administration draw inspiration from, as New Public Management (NPM) principles are showing some signs of exhaustion? What changes can be observed in the users’ expectations towards the administration? What role will instruments of digital governance play in this new configuration? How will the public administration react to the competition of new providers of services to the public? [less ▲]

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See detailNumerical prediction of ductile failure in the blanking process by means of uncoupled and coupled phenomenological damage models
Canales Cardenas, Cristian ULiege; Ponthot, Jean-Philippe ULiege

in MATEC Web of Conferences (2016)

Fracture prediction in blanking has gained great attention due to increasing requirements of high-quality products. In this work, the predictive capabilities of different uncoupled and coupled damage ... [more ▼]

Fracture prediction in blanking has gained great attention due to increasing requirements of high-quality products. In this work, the predictive capabilities of different uncoupled and coupled damage models, recently implemented in a fully implicit homemade FE code, for blanking process are compared. Some advanced models considered here include damage sensitivity to both triaxiality and Lode angle in their formulation. The material characterization is based on the history of internal variables during loading, where different mechanical tests are considered. Finally, numerical and experimental results are compared for a wide range of different geometries of blanking. [less ▲]

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See detailPulsations in hot subdwarf stars: recent advances and prospects for testing stellar physics
Charpinet, Stéphane; Van Grootel, Valérie ULiege; Fontaine, G. et al

in Proceedings of the International Astronomical Union (2016), 29

The evolved, core helium burning, extreme horizontal branch stars (also known as hot B subdwarfs) host several classes of pulsators showing either p- or g-modes, or both. They offer particularly favorable ... [more ▼]

The evolved, core helium burning, extreme horizontal branch stars (also known as hot B subdwarfs) host several classes of pulsators showing either p- or g-modes, or both. They offer particularly favorable conditions for probing with asteroseismology their internal structure, thus constituting arguably the most interesting seismic window for this intermediate stage of stellar evolution. G-modes in particular have the power to probe deep inside these stars, down to the convective He-burning core boundary where uncertain physics (convection, overshooting, semi-convection) is at work. Space data recently obtained with CoRoT and Kepler are offering us the possibility to probe these regions in detail and possibly shed new light on how these processes shape the core structure. In this short paper, we present the most recent advances that have taken place in this field and we provide hints of the foreseen future achievements of hot subdwarf asteroseismology. [less ▲]

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See detailPrevalence of vasculare risk factors in different stages of prodromal Alzheimer’s disease and its influence on cognitive decline
Bos, I.; Vos, S.; Frölich, L. et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2016), 12(7), 1059-1061

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See detailTrace metals in soft tissue of marine bivalve Noah's ark (Arca noao) from Bizerte lagoon (Northern Tunisia)
Ghribi, Feriel; Richir, Jonathan ULiege; Boussafa, Dhouha et al

in Rapports et Procès Verbaux des Réunions - Commission Internationale pour l'Exploration Scientifique de la Mer Mediterranée (2016), 41

This study aimed to monitor the bioaccumulation of 5 trace elements (TEs: Zn, Fe, Cu, Cd, and Pb) in the soft tissue of the Ark shell (Arca noae), seasonally sampled in Bizerte lagoon, northern Tunisia ... [more ▼]

This study aimed to monitor the bioaccumulation of 5 trace elements (TEs: Zn, Fe, Cu, Cd, and Pb) in the soft tissue of the Ark shell (Arca noae), seasonally sampled in Bizerte lagoon, northern Tunisia, in order to assess the nutritional quality of this bivalve and to promote its consumption as marine resource in Tunisia. The levels of all trace metals analyzed in Arca noae are below maximum admissible level which makes this species a healthy and safe food for human consumption. [less ▲]

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See detailFunctional respiratory imagning-aided virtual preoperative planning in nasal surgery: towards a personalized approach.
Ansari, Edward; Vos, Wim; Van Holsbeke, Cedric et al

in B-ENT (2016)

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See detailЛексико-семантическое калькирование в финансово-экономической сфере
Kolyaseva, Alena ULiege

in Новая экономика и региональная наука (New economy and the regional science), #2 (5) (2016)

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See detailThe model of endotoxemia in rats after subdiaphragmatic vagotomy
Koulchitsky, Stanislav ULiege; Netukova, Nina; Navratil, Leos et al

in Proceedings of the seventh workshop on experimental models and methods in biomedical research (2016)

Escherichia coli lipopolysaccharide (3 µg/kg) injection intravenously to rats (n=23) is accompanied with development of polyphasic fever and shift of nociceptive reactions threshold to hypo- or ... [more ▼]

Escherichia coli lipopolysaccharide (3 µg/kg) injection intravenously to rats (n=23) is accompanied with development of polyphasic fever and shift of nociceptive reactions threshold to hypo- or hyperalgesia according to fever phase. The blockade of afferent and efferent signals after vagotomy disturbs formation of fever and nociceptive reactions pattern. Therefore, obtained data allow explaining the phenomenon of nociceptive reactions and fever threshold shift after imperative change of signals flow through vagus nerve (for example, during qigong practicing) [less ▲]

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See detailOn the management of neurotransmitter imbalance after the use of neurotransmitter ligands or dielectrics in hypoxia
Koulchitsky, Stanislav ULiege; Pashkevich, Svetlana; Grinchik, Nikolay et al

in Proceedings of the seventh workshop on experimental models and methods in biomedical research (2016)

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See detailTargeted migration of stem cells in the model of brain trauma
Stukach, Y.; Koulchitsky, Stanislav ULiege; Shanko, Y. et al

in Proceedings of the seventh Workshop on Experimental Models and Methods in Biomedical Research (2016)

Objective: to develop technique of stem cells migration to the brain along trunks of cranial nerves during brain injury modeling. Methods: 40 anesthetized white rats were fixed in stereotaxis and ... [more ▼]

Objective: to develop technique of stem cells migration to the brain along trunks of cranial nerves during brain injury modeling. Methods: 40 anesthetized white rats were fixed in stereotaxis and subjected to craniotomy (20 rats at anterior cranial fossa (group 1) and 20 rats at posterior cranial fossa (group 2). 100 µl of brain tissue were bilaterally aspirated from somatosensory zone and cerebellar cortex in 1st and 2nd groups, respectively. Mesenchymal stem cells (labeled with PKH67 green fluorescent linker) were injected in 10 minutes: intranasally (10 animals) and to Meckel cavity (10 animals) in both groups. Animals were observed and sacrificed at certain periods of time after the operation during three weeks. Results: Appearance of small groups of mesenchymal stem cells in cranial cavity was established in 30 minutes after the operation. The highest fluorescence was observed at the damaged zone from 14 till 21 day after labeled stem cells implantation. Mesenchymal stem cells were predominantly distributed at the damaged zone in anterior cranial fossa after intranasal injection, and injection of stem cells to Meckel cavity resulted in their pronounced accumulation in the zone of cerebellar cortex injury (posterior cranial fossa). Conclusion: The fact of somatotopic arrangement of mesenchymal stem cells in cranial cavity according to application zone near cranial nerve endings was established. Intranasal injection of mesenchymal stem cells is followed by their distribution in damaged zone in anterior cranial fossa. Injection of mesenchymal stem cells to Meckel cavity leads to accumulation of labeled cells in damaged zone in posterior cranial fossa. [less ▲]

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See detailComparison of two non-invasive 2% enilconazole infusion protocols for treatment of canine sinonasal aspergillosis and importance of debridement for treatment efficacy.
Girod, Maud; Goosens, Damien; Volpe, Rosario ULiege et al

in Journal of Veterinary Internal Medicine (2016), 30

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See detailEndoscopic investigation of the gastroesophageal junction dynamics in dogs with brachycephalic syndrome.
Vangrinsven, Emilie ULiege; Broux, Olivier ULiege; Claeys, Stéphanie ULiege et al

in Journal of Veterinary Internal Medicine (2016), 30

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See detailA randomized double-blind study of denosumab compared with zoledronic acid in postmenopausal women with osteoporosis previously treated with oral bisphosphonate.
MILLER, P.D.; PANNACCIULLI, N.; BROWN, J.P. et al

in Arthritis and Rheumatology (2016), 67(S10), 1181-1182

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See detailEnforcing linear dynamics through the addition of nonlinearity
Habib, G.; Grappasonni, C.; Kerschen, Gaëtan ULiege et al

in Conference Proceedings of the Society for Experimental Mechanics Series (2016), 1

The current trend of developing more slender structures is increasing the importance of nonlinearities in engineering design, which, in turn, gives rise to complicated dynamical phenomena. In this study ... [more ▼]

The current trend of developing more slender structures is increasing the importance of nonlinearities in engineering design, which, in turn, gives rise to complicated dynamical phenomena. In this study, we evidence the somewhat paradoxical result that adding purposefully nonlinearity to an already nonlinear structure renders the behavior more linear. Isochronicity, i.e., the invariance of natural frequencies with respect to oscillation amplitude, and the force-displacement proportionality are two key properties of linear systems that are lost for nonlinear systems. The objective of this research is to investigate how these properties can be enforced in a nonlinear system through the addition of nonlinearity. To this end, we exploit the nonlinear normal modes theory to derive simple rules, yet applicable to real structures, for the compensation of nonlinear effects. The developments are illustrated using numerical experiments on a cantilever beam possessing a geometrically nonlinear boundary condition. © The Society for Experimental Mechanics, Inc. 2016. [less ▲]

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See detailt(12;21)/TEL-AML1 confers a specific pattern of in vivo sensitivity to treatments in childhood B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)
Piette, Caroline ULiege; Suciu, Stefan; Clappier, Emmanuelle et al

in Blood (2015, December 07)

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See detailQualités métrologiques de la version courte du Neurophysiology of Pain Questionnaire
Demoulin, Christophe ULiege; Brasseur, P.; Roussel, N. et al

in Revue du Rhumatisme (2015, December), 82S

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See detailCroyances de la population générale au sujet des manipulations vertébrales
Demoulin, Christophe ULiege; Baeri, D.; TOUSSAINT, Geoffrey ULiege et al

in Revue du Rhumatisme (2015, December), 82S

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See detailSpiral Arms in the Disk of HD 142527
Christiaens, Valentin ULiege; Casassus, Simon; Pérez, Sebastian et al

in Astronomical Society of the Pacific Conference Series (2015, December), 499

In view of its large gap, previously reported asymmetries and near-infrared (NIR) spiral arms, the transition disk of the Herbig Fe star HD 142527 constitutes a remarkable case study. Based on our ALMA ... [more ▼]

In view of its large gap, previously reported asymmetries and near-infrared (NIR) spiral arms, the transition disk of the Herbig Fe star HD 142527 constitutes a remarkable case study. Based on our ALMA observations of the disk and previous NIR images, we try to infer the origin of the observed spirals. Different scenarios, including the effect of the binary companion, unseen planets, disk self-gravity and tidal interaction by a stellar encounter, are discussed in order to constrain the origin of the spirals. We conclude that at least a combination of two of the considered scenarios are required to account for the large annular gap, the NIR spirals and all three CO spirals. [less ▲]

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See detailAn Effective Approach for the Control of Uncertain Systems
Wanichanon, Thanapat; Cho, Hancheol ULiege; Udwadia, Firdaus

in ABCM International Congress of Mechanical Engineering (2015, December)

This paper develops a new methodology for robust control of uncertain nonlinear systems. Two different controllers are developed and combined to accurately satisfy control requirements in the presence of ... [more ▼]

This paper develops a new methodology for robust control of uncertain nonlinear systems. Two different controllers are developed and combined to accurately satisfy control requirements in the presence of (a) system uncertainties in our knowledge of the exact physical system, and (b) uncertainties in the given forces acting on the system. The methodology is developed in two steps. First, a controller is designed for the nominal system, which is our best assessment of the actual physical system, and no uncertainties are considered at this step. This controller is realized using a recent finding in the field of analytical dynamics. The control requirements are recast as constraints on the dynamical system, and use of the analytical dynamics result enables us to find the required generalized forces to exactly satisfy the control requirements while simultaneously minimizing a control cost. The discrepancies caused by ignoring the uncertainties are next compensated for by adding a second controller that is obtained by generalizing the concept of sliding mode control. Unlike conventional sliding mode controllers, this additive controller does not suffer from a chattering problem; it also leads to much smaller errors, and faster response. In addition, it allows many different forms of control functions to be used, depending on practical considerations of implementation. A numerical example of a three-degree-of-freedom pendulum is simulated to demonstrate the control strategy developed herein, in which there are uncertainties both in the description of the physical system’s parameters and in the description of the gravity field acting on the pendulum. The example illustrates the accuracy, efficiency, and ease of implementation of the new control methodology. [less ▲]

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See detailEvaluation of simplified flexibility evaluation tools using a unit commitment model
Quoilin, Sylvain ULiege; Nijs, Wouter; Hidalgo, Ignacio et al

in IEEE Digital Library (2015, December)

Different tools and methods have been proposed in the literature to assess the required flexibility resources and needs in a particular grid or geographical area. However, few of them are readily usable ... [more ▼]

Different tools and methods have been proposed in the literature to assess the required flexibility resources and needs in a particular grid or geographical area. However, few of them are readily usable in long term energy planning models because they require small time steps and detailed data. In this paper, two candidate methods to address the flexibility issues in such models are evaluated. A unit commitment model developed at the JRC, DispaSET 2.0, is used as a test case for the different simplified flexibility assessment tools. The modelled geographical area is Belgium, using historical data for the demand and VRE curves and their day-ahead forecast. Different VRE penetration scenarios are simulated to evaluate the flexibility of the power system. The simplified assessment tools are then run with the same inputs. Results indicate significant discrepancies between the detailed Unit Commitment model and the simplified tools. The underlying reasons are described and suggestions are formulated to improve their accuracy. [less ▲]

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See detailBlockade of Interleukin 27 Signaling Attenuates Graft Versus Host Disease By Augmenting CD4+ and CD8+ Regulatory T Cell Reconstitution
Belle, Ludovic ULiege; Agle, K; Zhou, V et al

in Blood (2015, December), 126

The interleukin-6 (IL-6) cytokine superfamily (i.e. IL-6, IL-12, and IL-23) plays a major role in the modulation of inflammatory and regulatory pathways during graft versus host disease (GVHD). IL-27, a ... [more ▼]

The interleukin-6 (IL-6) cytokine superfamily (i.e. IL-6, IL-12, and IL-23) plays a major role in the modulation of inflammatory and regulatory pathways during graft versus host disease (GVHD). IL-27, a recently discovered member of this family, is a heterodimeric cytokine that is composed of the p28 and EBI3 subunits and signals through a heterodimeric receptor composed of WSX-1 and gp130. Notably, IL-6 also uses gp130 as a signaling component which biologically links IL-27 and IL-6. IL-27 has been shown to have opposing proinflammatory and immunoregulatory effects, but its role in GVHD is not well understood. To define the functional significance of IL-27, lethally irradiated Balb/c (H-2d) mice were transplanted with C57BL/6J (H-2b) BM and spleen cells, and then treated with an anti-IL-27p28-specific antibody on days 0 and +6. p28 antibody-treated animals had significantly improved weight recovery and overall survival (47% versus 0% survival at day 60, p=0.002), as well as reduced numbers of proinflammatory CD4+ and CD8+ IFN-γ+ T cells in GVHD target organs, when compared to isotype control antibody-treated mice. A similar outcome was observed in an MHC-matched, minor antigen disparate model (B6→Balb.B), indicating that this was not a strain-specific phenomenon. Given the similarities between IL-6 and IL-27, we examined whether blockade of IL-27 promoted regulatory T cell (Treg) reconstitution as has been observed with inhibition of IL-6 signaling. Recipients transplanted with BM grafts from B6 Foxp3EGFP reporter animals and treated with p28 antibody had a significant increase in the number of CD4+ nTregs, CD4+ iTregs and CD8+ iTregs in GVHD target organs, indicating that blockade of IL-27 augmented global Treg reconstitution. In fact, inhibition of IL-27 was more effective at augmenting Treg reconstitution than comparable antibody blockade of IL-6. To further elucidate the role of IL-27, we employed transgenic IL-27−/− and IL-27R−/− animals to dissect the relevant contributions of donor and recipient populations. Paradoxically, we observed that transplantation with IL-27−/− donor grafts exacerbated GVHD mortality and augmented accumulation of proinflammatory T cells, whereas transplantation of recipient IL-27−/− mice with wild type grafts had no effect on transplant outcomes. This discordance between antibody-based and genetic studies was unexpected and led us to consider whether there were steady state alterations in T cells from IL-27−/− animals that biased these cells towards a proinflammatory phenotype. To that end, we observed that naive CD8+ T cells from IL-27−/− mice had greater IFN-γ production than wild type cells after in vitro polyclonal stimulation and CD4+ nTregs from these animals had diminished expression of CXCR3 which is critical for Treg trafficking into inflamed tissue sites. Thus, the lack of endogenous IL-27 resulted in intrinsic immune dysregulation which led to an exacerbation of GVHD after transfer of these T cells into recipients. To resolve this paradox, we employed IL-27R−/− (WSX-1−/−) mice and demonstrated that mice transplanted with IL-27R−/− grafts had enhanced weight recovery and survival providing confirmation that blockade of IL-27 signaling reduced GVHD. In addition, using IL-27R−/− Foxp3EGFP reporter mice, we observed increased frequencies and numbers of CD4+ and CD8+ Foxp3+ T cells in mice reconstituted with IL-27R−/− grafts, confirming results observed with p28 antibody blockade. Since IL-10 is a mechanism by which CD4+ Tregs suppress GVHD and IL-27 has been shown to enhance T cell-derived IL-10 secretion in nontransplant models, we examined whether IL-27 blockade adversely affected IL-10 production by Tregs. Recipients transplanted with marrow grafts from IL-10.BitFoxp3EGFP dual reporter animals and treated with p28 antibody had a significant reduction in the frequency of IL-10-producing conventional CD4+ and CD8+ T cells in GVHD target organs. Notably, however, there was no difference in the frequency of CD4+ Foxp3+ IL-10+ T cells, indicating that blockade of IL-27 signaling preferentially affected conventional T cells and had no adverse effect on CD4+ Foxp3+ T cell-derived IL-10 production. In summary, these studies demonstrate that blockade of IL-27 signaling potently augments Treg reconstitution leading to a reduction in the severity of GVHD and may therefore represent a novel strategy to reduce mortality from this disease in man. [less ▲]

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See detailWho are my Visitors and Where do They Come From? An Analysis Based on Foursquare Check-ins and Place-based Semantics.
Hallot, Pierre ULiege; Stewart, Kathleen; Billen, Roland ULiege

in Eurographics Workshop on Urban Data Modelling and Visualisation 2015 (2015, November 23)

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This ... [more ▼]

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This research investigates to what extent the anonymized data collected from social networks can be used as a basis for making activity recommendations associated with local residents versus tourists when visiting a public place, such as a museum or gallery. Using rules based on the spatial, temporal and semantics of visited places, we are able to infer if a user is likely to be local or a tourist, based on anonymous sample Foursquare data and place-based semantics retrieved using Google Places API. Using semantics of visited places, it becomes possible to infer additional information about a user based on their movements over space and time. Depending on the kind and frequency of visited places, inferences about the aim of a visit to a location are possible. This analysis could provide information to users in the form of recommendations based on their movements while travelling around an area. This study has been performed using Foursquare check-ins for visitors to the Art Institute of Chicago between March 2010 and January 2011. [less ▲]

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See detailReliability maps for seismic tomography
Fechner, Thomas; Ehosioke, Solomon ULiege; Mackens, Sonja et al

in SEG Global Meeting Abstracts (2015, November 06)

Seismic borehole tomography has become a standard method and is routinely used for the detection of karstic phenomena and the delineation of geological structures. Seismic tomography is believed to be the ... [more ▼]

Seismic borehole tomography has become a standard method and is routinely used for the detection of karstic phenomena and the delineation of geological structures. Seismic tomography is believed to be the seismic method promising the most accuracy and reliability. Remaining uncertainties due to a non-zero residual is often neglected. However, the quality of the photographs is very high. We present tomographic inversion results in the signal-to-noise ratio of the first arrival time. This new data quality weighting scheme is assumed to provide more reliable inversion results. Information about the reliability of the tomogram provided with the geophysicist interpretation. The effect of the data quality weighted inversion is studied on a field data set. [less ▲]

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See detailFive years of comet narrow band photometry and imaging with TRAPPIST
Opitom, Cyrielle ULiege; Jehin, Emmanuel ULiege; Manfroid, Jean ULiege et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

TRAPPIST is a 60-cm robotic telescope in La Silla Observatory [1] mainly dedicated to the study of exoplanets and comets. The telescope is equipped with a set of narrow band cometary filters designed by ... [more ▼]

TRAPPIST is a 60-cm robotic telescope in La Silla Observatory [1] mainly dedicated to the study of exoplanets and comets. The telescope is equipped with a set of narrow band cometary filters designed by the NASA for the Hale-Bopp observing campaign [2]. Since its installation in 2010, we gathered a high quality and homogeneous data set of more than 30 bright comets observed with narrow band filters. Some comets were only observed for a few days but others have been observed weekly during several months on both sides of perihelion. From the images, we derived OH, NH, CN, C[SUB]2[/SUB], and C[SUB]3[/SUB] production rates using a Haser [3] model in addition to the Afρ parameter as a proxy for the dust production. We computed production rates ratios and the dust color for each comet to study their composition and followed the evolution of these ratios and colors with the heliocentric distance.The TRAPPIST data set, rich of more than 10000 images obtained and reduced in an homogeneous way, allows us to address several fundamental questions such as the pristine or evolutionary origin of composition differences among comets. The evolution of comet activity with the heliocentric distance, the differences between species, and from comet to comet, will be discussed. Finally, the first results about the one year campaign on comet C/2013 US10 (Catalina) and our recent work on the re-determination of Haser scalelengths will be presented.[1] Jehin et al., The Messenger, 145, 2-6, 2011[2] Farnham et al., Icarus, 147, 180-204, 2000[3] Haser, Bulletin de l’Académie Royal des Sciences de Belgique,63, 739, 1957 [less ▲]

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See detailNitrogen Isotopic Ratios in Cometary NH2: Implication for 15N-fractionation in Ammonia
Shinnaka, Yoshiharu; Kawakita, Hideyo; Jehin, Emmanuel ULiege et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Isotopic ratios in cometary molecules are diagnostic for the physico-chemical conditions where molecules formed and are processed, from the interstellar medium to the solar nebula. Usually temperatures at ... [more ▼]

Isotopic ratios in cometary molecules are diagnostic for the physico-chemical conditions where molecules formed and are processed, from the interstellar medium to the solar nebula. Usually temperatures at the molecular formation control the fractionation of the heavier element in molecular species, e.g., D-fractionation in water.In cometary volatiles, the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in CN have been well observed (Manfroid et al. 2009, A&A, 503, 613, and reference therein) and is consistent with the ratio in HCN (a most probable parent of CN) measured in few comets (Bockelée-Morvan et al. 2008, ApJ, 679, L49). Those ratios are enriched compared to the proto-solar value by a factor of ~3. In contrast to those Nitriles, there are only few reports on [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in Ammonia (as Amine) (Rousselot et al. 2014, ApJ, 780, L17; Shinnaka et al. 2014, ApJ, 782, L16). Ammonia (NH[SUB]3[/SUB]) is usually the most abundant and HCN is the second most abundant N-bearing volatiles in cometary ice. Especially, recent observations of [SUP]15[/SUP]NH[SUB]2[/SUB] revealed the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] are comparable to those of CN. However, from the viewpoint of theoretical work, the enrichment of [SUP]15[/SUP]N in cometary NH[SUB]3[/SUB] cannot be reproduced by current chemical network models. Information about the diversity of the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] of individual comets is needed to understand the formation mechanisms/environments of NH[SUB]3[/SUB] in the early solar system.To clarify the diversity of the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in cometary NH[SUB]3[/SUB], we determine the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] for more than ten comets individually which include not only Oort cloud comets but also short period comets by using the high-resolution optical spectra of NH[SUB]2[/SUB]. These spectra were obtained with both the UVES mounted on the VLT in Chile and the HDS on the Subaru Telescope in Hawaii.The derived [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] for more than ten comets show high [SUP]15[/SUP]N-enrichment compared with the elemental abundances of nitrogen in the Sun by about factor of ~3 and has no large diversity depending on these dynamical properties. We discuss about the origin of the formation conditions of cometary NH[SUB]3[/SUB] and its physico-chemical evolution in the solar nebula based on our and other results.This work was supported by JSPS, 15J10864 (Y. Shinnaka). [less ▲]

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See detailPluto's atmosphere from stellar occultations in 2012 and 2013
Dias-Oliveira, Alex; Sicardy, Bruno; Lellouch, Emmanuel et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

We present results from two Pluto stellar occultations observed on 18 July 2012 and 04 May 2013, and monitored respectively from five and six sites in South America. Both campaigns involved large ... [more ▼]

We present results from two Pluto stellar occultations observed on 18 July 2012 and 04 May 2013, and monitored respectively from five and six sites in South America. Both campaigns involved large telescopes (including the 8.2-m VLT at ESO/Paranal). The high SNR ratios and multi-chord coverage provide amoung the best Pluto atmospheric profiles ever obtained from the ground.We show that a spherically symmetric, clear (no-haze) and pure N2 atmosphere with a unique temperature profile satisfactorily fits the twelve lightcurves provided by the two events. We find, however, a small but significant increase of pressure of 6% (6-sigma level) between the two dates, with values of 2.16 ± 0.2 and 2.30 ± 0.01 μbar at the reference radius 1275 km, respectively.We provide atmospheric constrains between 1190 km and 1450 km from Pluto's center, and we determine the temperature profile with accuracy of a few km in vertical scale. Our model shows a stratosphere with strong positive gradient between 1190 km (at 36 K, 11 μbar) and r =1215 km (6.0 μbar), where a temperature maximum of 110 K is reached. Above it is a mesosphere with negative thermal gradient of -0.2 K/km up to 1,390 km (0.25 μbar), at which point, the mesosphere connects itself to a more isothermal upper branch at 81 K. This profile provides (assuming no troposphere) a Pluto surface radius of 1190 ± 5 km, consistent with preliminary values obtained by New Horizons. Currently measured CO abundances are too low to explain the negative mesospheric thermal gradient. We explore the possibility of an HCN (recently detected by ALMA) cooling. This model, however, requires largely supersaturated HCN. Zonal winds and vertical compositional variations of the atmosphere are also unable to explain the observed mesospheric trend.These events are the last useful ground-based occultations recorded before the 29 June 2015 occultation observed from Australia and New Zealand, and before the NASA's New Horizons flyby of July 2015. This work can serve as a benchmark in the New Horizons context, enabling comparisons between ground-based and space results concerning Pluto's atmospheric structure and temporal evolution. [less ▲]

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See detailReport on the ground-based observation campaign of 67P/Churyumov-Gerasimenko
Jehin, Emmanuel ULiege

in Bulletin of the American Astronomical Society (2015, November 01), 47

Rosetta gets closer to the nucleus than any previous mission, and returns wonderfully detailed measurements from the heart of the comet, but at the cost of not seeing the large scale coma and tails. The ... [more ▼]

Rosetta gets closer to the nucleus than any previous mission, and returns wonderfully detailed measurements from the heart of the comet, but at the cost of not seeing the large scale coma and tails. The ground-based campaign fills in the missing part of the picture, studying the comet at about 1000 km resolution, and following how the overall activity of the comet varies. These data provide context information for Rosetta, so changes in the inner coma seen by the spacecraft can be correlated with the phenomena observable in comets. This will not only help to complete our understanding of the activity of 67P, but also to allow us to compare it with other comets that are only observed from the ground.The ground-based campaign includes observations with nearly all major facilities world-wide. In 2014 the majority of data came from the ESO VLT, as the comet was still relatively faint and in Southern skies, but as it returns to visibility from Earth in 2015 it is considerably brighter, approaching its perihelion in August, and at Northern declinations. I will present results from the 2014 campaign, including visible wavelength photometry and spectroscopy, and the latest results from 2015 observations. [less ▲]

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See detailChariklo's size, shape and orientation from stellar occultations
Bérard, Diane; Sicardy, Bruno; Assafin, Marcelo et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Chariklo is the largest Centaur object known to date, and it is surrounded by dense and narrow rings (Braga-Ribas et al. Nature 508, 72, 2014). The size, shape and orientation of the central body are ... [more ▼]

Chariklo is the largest Centaur object known to date, and it is surrounded by dense and narrow rings (Braga-Ribas et al. Nature 508, 72, 2014). The size, shape and orientation of the central body are important parameters to better understand the dynamics of the rings.In that context, we have analyzed three stellar occultations by Chariklo and its main ring observed on June 3, 2013, April 29, 2014 and June 28, 2014. Elliptical limb fitting to Chariklo’s main body occultation chords has been performed, where we denote a (resp. b) the semi-major (resp. semi-minor) axis of the limb. Preliminary results indicate that Chariklo’s limb is elliptical with axes ratio b/a~0.89. We obtain a~133 km and b~119 km, providing an equivalent radius of R[SUB]equiv[/SUB]=√(ab)~126 km. The rms dispersion of the fit, about 4 km, is compatible with local topographic features on a small icy body. For comparison, an equivalent radius of R[SUB]equiv[/SUB]= 119±5 km, based on thermal data, is given by Fornasier et al, AA 518, L11, 2014, while Duffard et al. AA 568, A79, 2014 estimate a= 122 km and b= 117 km.Our results are obtained under the simplifying assumption that the main ring is circular and that its center coincides with that of Chariklo. Caveats and error bars will be discussed, and dynamical implications will be presented. In particular, rough estimations of the ring apsidal precession rates will be given, as well as constraints on Chariklo's density. [less ▲]

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See detailOutgassing and chemical evolution of C/2012 S1 (ISON)
Dello Russo, Neil; Vervack, Ronald J.; Kawakita, Hideyo et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ~ 25,000) infrared ... [more ▼]

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ~ 25,000) infrared spectroscopy as part of a worldwide observing campaign. Spectra were obtained on UT 2013 October 26 and 28 with NIRSPEC at the W. M. Keck Observatory, and UT 2013 November 19 and 20 with CSHELL at the NASA IRTF. H[SUB]2[/SUB]O was detected on all dates, with production rates increasing by about a factor of 40 between October 26 (R[SUB]h[/SUB] = 1.12 AU) and November 20 (R[SUB]h[/SUB] = 0.43 AU). Short-term variability of H[SUB]2[/SUB]O was also seen as the production rate increased by nearly a factor of two during observations obtained over a period of about six hours on November 19. C[SUB]2[/SUB]H[SUB]6[/SUB], CH[SUB]3[/SUB]OH and CH[SUB]4[/SUB] abundances were slightly depleted relative to H[SUB]2[/SUB]O in ISON compared to mean values for comets measured at infrared wavelengths. On the November dates, C[SUB]2[/SUB]H[SUB]2[/SUB], HCN and OCS abundances relative to H[SUB]2[/SUB]O appear to be close to the range of mean values, whereas H[SUB]2[/SUB]CO and NH[SUB]3[/SUB] were significantly enhanced. We will compare derived chemical abundances in ISON to other comets measured with infrared spectroscopy. [less ▲]

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See detailTransfusion needs during liver transplantation at the chu of liege (belgium): characteristics and preoperative predictive factors
PAGE, Isaline ULiege; HANS, Grégory ULiege; DETRY, Olivier ULiege et al

in Transplant International (2015, November), 28(S4), 461272

Introduction: Liver transplantation (LT) can result in significant bleeding requiring transfusion of allogenic blood products, which potentially leads to postoperative morbidity and mortality (1). This ... [more ▼]

Introduction: Liver transplantation (LT) can result in significant bleeding requiring transfusion of allogenic blood products, which potentially leads to postoperative morbidity and mortality (1). This study aimed to determine transfusion needs during LT in our institution and its preoperative predictive factors. Material and Methods: Two hundred LT performed at the CHU Liege between 2006 and 2012 were respectively reviewed (age = 55 ` 11 yo, BMI = 25.5 ` 4.4 kg/m2, F/M = 45/155, MELD score = 19 ` 10). Transfu- sion needs of the different blood products during POD 0, and POD 0–7 were recorded. Parameters associated with the transfusion of more than 2 units of RBC (p ≤ 0.1) were identified using the Kruskal Wallis and chi square tests (table 1). These parameters were then placed into a backward stepwise logistic regression model for the transfusion of more than two units of RBC at POD 0. A p value threshold ≥0.1 was used for leaving the model. Results: Transfusion needs were: RBC = 2[0–4], FFP = 4[2–7], PLT = 1[0– 1] during POD 0; and RBC = 3[0–6], FFP = 6[3–10], PLT = 1[0–2] during POD 0–7. Preoperative factors independently associated with the transfusion of more than two units of RBC were preop Hb (0.6 [0.46–0.79], p < 0.001) and MELD score (1.13 [1.06–1.20], p < 0.001). Discussion: These results suggest that preop Hb and MELD score are associated with blood requirements during LT. [less ▲]

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See detailA consecutive series of 100 controlled DCD liver transplantation
DETRY, Olivier ULiege; DE ROOVER, Arnaud ULiege; Ledinh, H et al

in Transplant International (2015, November), 28(S4), 109296

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and ... [more ▼]

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and retransplantation. The authors retrospectively reviewed a single centre experience with controlled DCD-LT in a 12-year period. Patients and Methods: 100 DCD-LT were consecutively performed between 2003 and 2014. All donation and procurement procedures were performed as controlled DCD in operative rooms. Data are presented as median (ranges). Median donor age was 57 years (16–83). Median DRI was 2.16 (1.4–3.4). Most grafts were flushed with HTK solution. Allocation was centre-based. Median recipient MELD score at LT was 15 (7–40). Mean follow-up was 35 months. No patient was lost to follow-up. Results: Median total DCD warm ischemia was 19 min (10–39). Median cold ischemia was 235 min (113–576). Median peak AST was 1132 U/l (282– 21 928). Median peak bilirubin was 28 mg/dL. Patient survivals were 90.7%, 75.5% and 70.7% at 1.3 and 5 years, respectively. Graft survivals were 88.7%, 72.1% and 67.1% at 1.3 and 5 years, respectively. Biliary complications included mainly anastomotic strictures and extrahepatic main bile duct ischemic obstruction, that were managed either by endoscopy or hepatico- jejunostomy. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Discussion: In this series, DCD LT appears to provide results similar to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. If symptomatic ischemic cholangiopa- thy is diagnosed, adequate management with endoscopy and surgical hepaticojejunostomy may avoid graft loss and retransplantation. [less ▲]

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See detailIncreased risk of interstitial fibrosis and tubular atrophy in controlled donation after circulatory death kidney transplantation
WEEKERS, Laurent ULiege; Ledinh, H; BONVOISIN, Catherine ULiege et al

in Transplant International (2015, November), 28(S4), 49118

Introduction: Comparable transplant outcomes between controlled donation after circulatory death (cDCD) and donation after brain death (DBD) kidney transplantation (KT) have been confirmed. However, few ... [more ▼]

Introduction: Comparable transplant outcomes between controlled donation after circulatory death (cDCD) and donation after brain death (DBD) kidney transplantation (KT) have been confirmed. However, few data describes the histology of cDCD-KT which is subjected to prolonged procurement warm ischemia. This study aimed to evaluate the rate of interstitial fibrosis (IF) and tubular atrophy (TA) on the surveillance biopsy performed in our unit between the 2 and 6 months post KT. Acute rejection was considered as secondary endpoint. Patients and Methods: 330 KT (226 DBD and 104 DCD) have been performed between 2008 and 2014. Surveillance or per-cause biopsy was performed in 272 recipients. Among them, the rate of adequate (≥8 glomeruli and ≥1 large-sized artery) was 76.8%. Results: IFTA was found in 11.5% and 25.7% of DBD and cDCD-KT, respectively (p = 0.004). Considering IF and TA separately, the corresponding rates were 20.4% vs 32% (p = 0.04) and 23% vs 36% (p = 0.03), respectively. If acute rejection before routine biopsy was excluded, either IF or TA rate was significantly higher in cDCD- than DBD-KT (12.6% vs 27.1%, p = 0.006; 17.6% vs 31.4%, p = 0.016; and 20.9% vs 35.7%, p = 0.015 in case of IF-TA, IF, and TA, respectively). A cDCD-KT compared to a DBD-KT was 3.11 (95%CI 1.51– 6.43, p = 0.002), 2.34 (95%CI 1.21–4.53, p = 0.011) and 2.29 (95%CI 1.23– 4.27, p = 0.009) times more likely to have IFTA, IF, and TA, respectively. Extended criteria donor (ECD) vs standard criteria donor (SCD) was also an independent risk factor for IFTA (OR = 3.11, 95%CI 1.51–6.43, p = 0.002), IF (OR = 4.86, 95%CI 1.96–12.05, p = 0.001), and TA (OR = 4.09, 95%CI 1.68– 9.93, p = 0.002). The rate of acute rejection diagnosed by SB was 7.1% and 8.9% in DBD and cDCD kidney grafts (p = ns), respectively.Conclusion: KT from cDCD increased the risk of IF-TA between 3 and 6 months post-transplant. Further studies are warranted to investigate the evolution of this phenomenon over time and its effect on graft function. [less ▲]

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See detailImpact of timing administration of mesenchymal stromal cells on serum creatinine following renal ischemia/ reperfusion in rats
ERPICUM, Pauline ULiege; Rowart, Pascal ULiege; POMA, Laurence ULiege et al

in Transplant International (2015, November), 28(S4), 1129

Experimental models of renal ischemia/reperfusion (I/R) have suggested protective effects of mesenchymal stromal cells (MSC) therapy. Still, param- eters of MSC injection, including volume, route and ... [more ▼]

Experimental models of renal ischemia/reperfusion (I/R) have suggested protective effects of mesenchymal stromal cells (MSC) therapy. Still, param- eters of MSC injection, including volume, route and timing of cell administration, remain largely debated. Particularly, MSC infusion in mouse has been shown to be beneficial “a priori” but deleterious “a posteriori” of renal I/R injury. In order to further investigate the influence of the timing of MSC administration, we used 10-week-old Lewis rats categorized in 4 groups. Groups 1 (MSC D-7, n = 10) and 2 (MSC D + 1, n = 7) received caudal i.v. injection of MSC (1.5 9 106 in 1 ml of saline) 7 days before or 1 day after renal I/R, respectively. Control groups 3 (saline D-7, n = 6) and 4 (saline D + 1, n = 6) received equal volume of saline at similar time points. Left renal ischemia (by clamping of the renal pedicle) lasted 45 min. Right nephrectomy was simultaneously performed. Blood sample was collected from inferior vena cava at 48 h post reperfusion. MSC phenotype was confirmed by FACS analysis. In groups 1 and 3, serum creatinine (SCr) reached 1.4 ` 0.7 versus 2.4 ` 0.8 mg/dl, respectively (p < 0.05). In groups 2 and 4, SCr was 4.9 ` 0.7 versus 3.3 ` 0.9 mg/dl, respectively (p < 0.001). Furthermore, SCr levels were statistically worse when MSC were administered after renal I/R in comparison to a priori infusion (p < 0.0001). In conclusion, MSC administration 7 days prior to renal I/R attenuates kidney injury in comparison to (i) saline infusion or (ii) MSC infusion 1 day after renal I/R. Conversely, on the basis of SCr levels, MSC therapy performed after renal I/R worsens kidney injury in rats. [less ▲]

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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULiege; VANDERMEULEN, Morgan ULiege; DELBOUILLE, Marie-Hélène ULiege et al

in Transplant International (2015, November), 28(S4), 1027

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Methods: 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5–3 9 106/kg third party MSC on post-operative day 3 ` 2. These patients were prospectively compared to a group of 10 control liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. This study is in part supported by an ESOT Senior Clinical Research Grant and by the University of Liege. [less ▲]

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See detailComparable transplant outcomes between DBD and DCD kidney grafts up to 5 years post-transplant: single centre experience
Ledinh, H; DETRY, Olivier ULiege; DE ROOVER, Arnaud ULiege et al

in Transplant International (2015, November), 28(S4), 193-194188

Introduction: This study aimed to determine the most recent results of kidney transplantation (KT) from donation after brain death (DBD) and circulatory death (DCD). Primary endpoints were graft and ... [more ▼]

Introduction: This study aimed to determine the most recent results of kidney transplantation (KT) from donation after brain death (DBD) and circulatory death (DCD). Primary endpoints were graft and patient survival, and graft function. Acute rejection and post-operative complications were assessed as secondary endpoints. Patient and Methods: This retrospective mono-center review consisted of 226 DBD- and 104 DCD-KT between 2008 and 2014. Results: Graft survival was comparable between two groups (95.1 vs. 91.1% at 1 year, 92.8 vs. 91.1% at 3 years and 89.2 vs. 91.1% at 5 years). 46% and 40% of graft loss were attributed to patient death with a functioning graft and rejection. Patient survival was comparable between 2 groups (97.8 vs. 95.1% at 1 year, 94.1 vs. 91.2% at 3 years, and 89.6 vs. 82.3% at five years). Etiology of patient death included cardiac arrest (16.7%), infection (16.7%), cancer (13.3%), and unknown cause (46.7%). Delayed graft function occurred in 14.6% of DBD- and 30.8% of DCD-KT (p = 0.001). Primary non function was encountered in 2.6% DBD- and 4.8% DCD-KT (p = ns). Graft function was worse in DCD than DBD up to 3 months post-transplant (p = 0.034), however, no difference existed afterwards. Biopsy-proven acute rejection was found in 12.8% and 13.5% of DBD- and DCD-KT during an average 3 months post- transplant (p = ns). This rate was 7.1% vs. 8.9% on surveillance biopsy performed between 3 and 6 months post-transplant (p = ns). Post-operativecomplication rate was comparable between 2 groups, concerning patient death, reoperation, transfusion, perirenal hematoma, macroscopic hematuria, urinary obstruction, wound problem, and infection. Nevertheless, contamination of preservation solution occurred more commonly in DCD than DBD (0.4% vs. 3.8%, p = 0.036). Conclusions: Despite worse early graft function, DCD-KT was not inferior to that originating from DBD up to 5 years post-transplant, therefore deserves to be used. [less ▲]

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See detailOrgan donation after euthanasia on specific patients' request in Belgium
Ysebaert, D; DETRY, Olivier ULiege; Verfaillie, G et al

in Transplant International (2015, November), 28(S4), 114313

Euthanasia is since 2002 legalized in Belgium for adults under strict conditions. The patient must be in a medically futile condition, of constant and unbearable physical or mental suffering that cannot ... [more ▼]

Euthanasia is since 2002 legalized in Belgium for adults under strict conditions. The patient must be in a medically futile condition, of constant and unbearable physical or mental suffering that cannot be alleviated, resulting from a serious and incurable disorder caused by illness. This implies that also non-terminal not-cancer patients can request for euthanasia for instance in case of debilitating neurological disorder. From 2005 till 2015 more than 25 patients, suffering from diverse neuropsychiatric diseases, got their request for euthanasia granted, and subsequently asked spontaneously for the possibility of organ donation. The involved physicians, the transplant teams and the Institutional Ethics Commit- tees, had the well-discussed opinion that this strong request for organ donation after euthanasia could not be denied. A clear separation between the euthanasia request, the euthanasia procedure and the organ procurement procedure was judged necessary. After extensive preparation, finally, in Belgium, 17 patients got their wish for organ donation after euthanasia fulfilled, in several academic or non-academic hospitals and in different regions. Several requests and preparations were started for other patients but ultimately did not lead to organ donation due to patients’ personal choices or logistically reasons. The euthanasia procedure was carried out by three physicians involved in the euthanasia granting. After clinical diagnosis of cardiac death, the procurement team came in and performed the organ procurement similar as in a DCD type III procedure. Almost always, liver, two kidneys and sometimes lungs and pancreatic islets were successfully recovered and transplanted, after allocation by Eurotransplant. The possibility of organ donation after their euthanasia provides a very much improved self-image of these patients, and adds something really positive to the unfortunate end-of-life of these patients. [less ▲]

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See detailTraitement par denosumab chez des hommes à masse osseuse basse: résultats à 24 mois de l'étude ADAMO
Chapurlat, R.; Langdahl, B.; Teglbjaerg, C. et al

in Revue du Rhumatisme (2015, November), 82(S1), 123-124

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See detailPourquoi dort-on?
BARREA, Christophe ULiege

in Congrès du GBPF (2015, November)

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See detailThird-party mesenchymal stem cell infusion in kidney transplant recipient: 6-month safety interim analysis
WEEKERS, Laurent ULiege; ERPICUM, Pauline ULiege; DETRY, Olivier ULiege et al

in Transplant International (2015, November), 28(S4), 223-224278

Background: Mesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents. We report the 6- month safety results for the 5 first patients treated with MSC ... [more ▼]

Background: Mesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents. We report the 6- month safety results for the 5 first patients treated with MSC after kidney transplantation (KTx). Here, we address 3 specific safety issues: immunization against MSC and engraftment syndrome defined as acute graft dysfunction not related to rejection and over-immunosuppression. Patients and method: MSC production was carried out locally. MSC were not matched with kidney recipients’ HLA. Included patients were non-immunized, first transplant recipients from deceased donors. MSC (1.5–3.0 9 106/kg) infusion was planned 3 to 5 days post KTx. Patients with cardiovascular instability post KTx were excluded. All patients were treated with Basiliximab induction, Tacrolimus, Mycophenolate Mofetil and Steroid. We prospectively screened for anti-HLA antibodies at month 1, 3 and 6. Informed consent was obtained from all participants. The local ethical committee approved the protocol. Results: Collectively there were 23/50 and 29/50 HLA mismatches (MM) with kidney and MSC donor respectively, out of which 5 were shared MM. One patient developed de novo DSA, 2 patients anti-HLA antibodies against shared kidney/MSC MM and 1 patient developed 2 specific antibodies against MSC (MSCSA) at month 6. All antibodies were anti HLA class I except for 1. We did not observe any “engraftment” syndrome. Three patients experienced non- severe opportunistic infections: 1 CMV reactivation and 2 polyoma-BK virus viremia.Conclusion: We did not observe any strong safety signal. We did however observe some degree of immunization in 3 patients: 2 developed antibodies against shared kidney/MSC donor HLA MM and 1 MSCSA. [less ▲]

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See detailPourcentage de femmes atteignant des T-scores de DMO non ostéoporotiques au rachis lombaire (RL) et à la hanche totale (HT) après 8 ans de traitement par denosumab (DMAb)
Ferrari, S.; Libanati, C.; Lin, J. et al

in Revue du Rhumatisme (2015, November), 82(S1), 35-36

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See detailLes machinimas : entre jeux et vidéos. Vers une poétique du détournement vidéoludique
Barnabé, Fanny ULiege

in Culture Numérique (2015, October 10)

Cet article a pour objectif d’ébaucher la construction d’une théorie du détournement de jeux vidéo par les joueurs en passant, non pas par une perspective sociologique ou anthropologique, mais par ... [more ▼]

Cet article a pour objectif d’ébaucher la construction d’une théorie du détournement de jeux vidéo par les joueurs en passant, non pas par une perspective sociologique ou anthropologique, mais par l’analyse formelle des œuvres dérivées. Pour ce faire, le présent travail prend pour objet une pratique spécifique de détournement, la réalisation de machinimas, et l’aborde à travers un corpus illustratif de vidéos ayant pour point commun d’être issues des jeux Halo. L’analyse détaillée de quatre exemples prototypiques permettra de démontrer, d’une part, l’intime continuité qui existe entre la production de détournements et la pratique même du jeu (continuité qui rend donc artificielle toute tentative de démarcation stricte) et, d’autre part, la nature duelle du détournement de jeux vidéo (due à l’existence de deux aspects à détourner : le game et le play). La mise en parallèle de ces réflexions aboutira, enfin, dans la formalisation d’un modèle cartographiant les multiples formes de détournements. [less ▲]

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See detailUnderstanding how people with MS get tired while walking
Pierard, Sébastien ULiege; Phan-Ba, Rémy; Van Droogenbroeck, Marc ULiege

in Multiple Sclerosis Journal (2015, October 09), 23(S11), 406

BACKGROUND. Walking impairment is frequent, appears early in the disease course of MS patients (MSP), and is perceived as the most disabling symptom. When walking, patients get tired more and differently ... [more ▼]

BACKGROUND. Walking impairment is frequent, appears early in the disease course of MS patients (MSP), and is perceived as the most disabling symptom. When walking, patients get tired more and differently than healthy people (HP) [Phan-Ba et al PLOS 2012]. This limits their walking perimeter. Understanding this phenomenon is thus important to suggest adequate therapies at the right time. OBJECTIVE. Our aim is to understand how MSP get tired while walking compared to HP. Two groups of MSP are considered: those with a low disability level (MSPL) and those with a high one (MSPH). We consider two criteria to measure the disability: the EDSS and the deceleration index (DI) [Phan-Ba et al PLOS 2012]. The limit between the groups is set at DI=0.8 and EDSS=3 (inclusive for MSPL). METHODS. Many gait characteristics (GC) have been measured with the system GAIMS along a 500m path walked as fast as possible. The dataset gathers 464 visits of HP and 70 of MSP. Some people have been assessed several times. There are 33 visits in the group MSPL with the EDSS criterion, and 25 with the DI criterion. Statistical tests (Welch) were performed on the differences and relative differences of the GC measured during the first and last 100m of the test to detect differences between HP and MSPL, and between MSPL and MSPH, as in [ECTRIMS 2012 P755]. RESULTS. Both criteria for defining the groups lead to similar conclusions. For many GC, the distributions of the variations are significantly different between MSPL and MSPH. The largest difference is for the relative difference of speed (p=0.000119 for EDSS and p=0.000021 for DI). In contrast, only the variation of the average lateral distance between the feet, which is related to the size of the base of support (and thus to the balance) shows a very significant difference between HP and MSPL (p=0.000116 for EDSS and p=0.000120 for DI). The balance does not seem to change much from MSPL to MSPH. Besides, we note that the variance decreases slightly from HP to MSPL and increases a lot from MSPL to MSPH. CONCLUSIONS. Statistically, from the motor fatigue point of view, it seems that the course of the MS disease is divided in two different stages. In the first one, MSP get more tired than HP because of a deterioration of the balance. Then, in the second one, their fatigue becomes related to a faster decrease of the walking speed. This suggests that physical therapy exercises focused on the balance could be given to MSP in the early stage of the disease. [less ▲]

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See detailDefining a score based on gait analysis for the longitudinal follow-up of MS patients
Azrour, Samir ULiege; Pierard, Sébastien ULiege; Van Droogenbroeck, Marc ULiege

in Multiple Sclerosis Journal (2015, October 09), 23(S11), 408-409

BACKGROUND. The project GAIMS [ECTRIMS 2013 P800] aims at developing a gait measuring system particularily suited for the clinical routine, and providing a reference database with the gait characteristics ... [more ▼]

BACKGROUND. The project GAIMS [ECTRIMS 2013 P800] aims at developing a gait measuring system particularily suited for the clinical routine, and providing a reference database with the gait characteristics of many MS patients (MSP) and healthy people (HP). As the gait impairments are related to the disease progression, defining an objective and quantitative score based on the gait characteristics would be useful for the longitudinal follow-up. Based on the dataset of GAIMS and machine learning techniques (MLT), a score, well correlated with the EDSS, can be defined [Azrour et al. ESANN 2014]. OBJECTIVE. Burggraaff et al. [ECTRIMS 2014 P033] showed that paired comparisons can help human raters to better judge the state of the patients. In the same spirit, we aim at predicting the difference of EDSS between two persons or between two visits of a same person, based on clinical gait measures. We show that the pairwise comparison strategy leads to a score (Gait-Score) well correlated with the EDSS and sensitive to small modifications of the gait. METHODS. The gait of 162 HP and 72 MSP (44 with EDSS>3) has been recorded and analyzed with GAIMS. The Gait-Score is defined using the MLT of [Geurts et al. 2006]. We can compute the Gait-Score of a person by comparing him to others with known EDSS, and compute the difference of Gait-Score of a same person at two different moments. We measure the merits of the Gait-Score by the correlation between the predicted Gait-Score and the EDSS, as well as the ability to detect subtle gait deteriorations among people with ataxia induced by a low dose of alcohol (data of [Piérard et al. ESANN 2014]). RESULTS. The Gait-Score is well correlated with the EDSS (Pearson’s correlation=0.8743). Moreover, it manages to detect a gait deterioration after a small alcohol intake for 19 persons out of 24 (79% correct) which is much better than what was obtained by visual inspection of neurologists (62% according to [Piérard et al. ESANN 2014]). CONCLUSIONS. Based on the accurate gait measures provided by GAIMS, we are able to derive a Gait-Score, automatically, that is well correlated with the EDSS. Moreover, this score is able to detect subtle deteriorations of the gait caused by a low dose of alcohol. These results reinforce our conviction that the use of an automatic method based on gait analysis is very promising for the longitudinal follow-up of MS patients and the assessment of the impact of new drugs and rehabilitation programs. [less ▲]

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See detailSynthèse du débat politique. Journée de réflexion au Sénat de Belgique: «Démocratie représentative : vers la fin d’un modèle ? Diagnostic et remèdes»
Verjans, Pierre ULiege

in Compte-rendu du Sénat de Belgique (2015, October 01)

Les réflexions des responsables politiques en réaction aux interventions des scientifiques peuvent être interprétées en fonction de grille d'analyse de science politique, notamment celle d'Amartya Sen et ... [more ▼]

Les réflexions des responsables politiques en réaction aux interventions des scientifiques peuvent être interprétées en fonction de grille d'analyse de science politique, notamment celle d'Amartya Sen et celle de Bernard Manin. [less ▲]

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See detailOnychomycosis: is it possible to increase the cure rate?
Hayette, Marie-Pierre ULiege

in Mycoses (2015, October), 58(suppl 4), 35

Onychomycosis represent about 50% of nails disorders in the world with a very variable prevalence depending of the countries considered. Dermatophytes, non-dermatophyte molds and Candida sp. are the main ... [more ▼]

Onychomycosis represent about 50% of nails disorders in the world with a very variable prevalence depending of the countries considered. Dermatophytes, non-dermatophyte molds and Candida sp. are the main causing agents. A rapid and accurate diagnosis is essential in order to give an adequate treatment to the patient. Generally, a combination of microscopy and culture is used for laboratory diagnosis. However, microscopy does not always allow the distinction between yeasts or filamentous fungi, culture takes generally about a week before identification and the result is compromised if there is contamination by not relevant fungi. Therefore commercially available PCR-based methods have been developed in order to provide a rapid and accurate identification of dermatophytes and yeasts in nails samples. Combination of microscopy and PCR may provide a rapid and specific diagnosis in 2 working days. However this methodology is still not widely used by laboratories because of the high cost. Furthermore, this technology can detect DNA from dead fungi and therefore is not suitable for assessment of treatment efficacy. Onychomycosis therapy depends on different factors such as the causative agent, the number of nails and degree of nail involvement, the type of onychomycosis, potential drug interactions or drug intolerance and a failure to previous treatments. Oral and topical antifungals are mostly used separately or in combination. Oral therapy includes azoles (itraconazole, fluconazole) and/or allylamine (terbinafin), this latter being the most frequently prescribed antifungal for treatment of onychomycosis in North America and Europe. Topical amorolfine and ciclopirox formulations can be used alone in mild cases or in case of intolerance to oral antifungals. However, one of the biggest problems of therapy for onychomycosis is the high frequency of relapse which concerns about 20 to 40% of the patients treated by oral antifungals. Different strategies have been developed to overcome this problem amongst which are: optimization of the dosing regimens (continuous vs pulse therapy) or therapy duration, combination therapy (nail debridement + antifungals, oral + topical drugs, 2 oral drugs), improving drug delivery (use of physical or chemical enhancers, and modification of the pharmacological formulation for increasing drug uptake). Some strategies such as combination therapy (oral + topical) have demonstrated enhanced efficacy and should be recommended in case of poor efficacy of the initial treatment or in case of extended infection. Prophylactic topical therapy implemented after completion of oral treatment has been shown to delay relapse. Preventive measures such as treatment of concurrent tinea pedis and/or infected family members and regular cleaning of bathroom and shower floors can help to reduce the risk of reinfection particularly when a dermatophyte is the causative agent. In conclusion, treatment for onychomycosis is associated with frequent relapse. Consequently, follow-up is mandatory and combination therapy can be necessary in case of relapse or resistance to treatment. Patients should also be aware of the preventive hygiene measures to apply in order to decrease the risk of reinfection. New strategies improving treatment efficacy are promising but their efficacy have still to be demonstrated in comparative clinical trials before their implementation in therapy. [less ▲]

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See detailMPLS Under the Microscope: Revealing Actual Transit Path Diversity
Vanaubel, Yves ULiege; Mérindol, Pascal; Pansiot, Jean-Jacques et al

in ACM Internet Measurement Conference (2015, October)

Traffic Engineering (TE) is one of the keys for improving packet forwarding in the Internet. It allows IP network operators to finely tune their forwarding paths according to various customer needs. One ... [more ▼]

Traffic Engineering (TE) is one of the keys for improving packet forwarding in the Internet. It allows IP network operators to finely tune their forwarding paths according to various customer needs. One of the most popular tool available today for optimizing the use of networking resources is MPLS. On the one hand, operators may use MPLS and label distribution mechanisms such as RSVP-TE in conjunction with BGP to define multiple transit paths (for a given edge pair) verifying different constraints on their network. On the other hand, when operators simply enable LDP for distributing MPLS labels in order to improve the scalability of their network, another kind of path diversity may appear thanks to the ECMP feature of IGP routing. In this paper, using an MPLS labels analysis, we demonstrate that it is possible to better understand the transit path diversity deployed within a given ISP. More specifically, we introduce the Label Pattern Recognition (LPR) algorithm, a method for analyzing traceroute data including MPLS information. LPR reveals the actual usage of MPLS according to the inferred label distribution protocol and is able to make the distinction between ECMP and TE multi-path forwarding. Based on an extensive and longitudinal traceroute dataset obtained from CAIDA, we apply LPR and find that each ISP behavior is really specific in regard to its MPLS usage. In particular, we are able to observe independently for each ISP the MPLS path diversity and usage, and its evolution over time. Globally speaking, the main outcomes of our study are that (i) the usage of MPLS has been increasing over the the last five years with basic encapsulation being predominant, (ii) path diversity is mainly provided thanks to ECMP and LDP, and, (iii), TE using MPLS is as common as MPLS without path diversity. [less ▲]

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See detailValidation of the DermaGenius Nail plus multiplex assay, a new commercial PCR assay developed for the detection and identification of dermatophyte and Candida in nails
Hayette, Marie-Pierre ULiege; GRAIDE, Hélène ULiege; ADJETEY BAHUN, Akolé ULiege et al

in Mycoses (2015, October), 58(suppl 4), 223

Objectives Superficial dermatophytosis is the most common fungal infection in humans. Diagnosis of dermatophytosis is currently based on microscopy or histology associated with culture on specific agar ... [more ▼]

Objectives Superficial dermatophytosis is the most common fungal infection in humans. Diagnosis of dermatophytosis is currently based on microscopy or histology associated with culture on specific agar media. However, direct microscopy lacks specificity and culturing has a long turn-around-time of 2-4 weeks. These limitations can be prevented by the use of molecular diagnostics. The DermaGenius (DG) multiplex kit (PathoNostics, The Netherlands) is a new commercial realtime-PCR kit, which can differentiate various dermatophytes species including the nail pathogens T. rubrum, T. mentagrophytes, T. interdigitale and 2 Candida species (C. albicans and C. parapsilosis). This study aimed at the validation of the kit on nails clippings. Results were compared with histology and culture data. Methods A set of 76 nail clippings was collected from 76 patients attending the dermatology consultation at the University Hospital of Liege on suspicion of onychomycosis. All nails were divided in three pieces for histology, culture and the PCR multiplex assay. Histologic preparations were stained with PAS staining. Cultures were performed on 2 different Sabouraud agar medium slants (bioMérieux). The DNA extraction protocol used a proteinase K pre-treatment followed by an automated DNA-extraction (EasyMag, bioMérieux). An Internal Control (IC) was included to monitor for PCR inhibition or manual errors. The realtime-PCR amplification was performed with the DG kit on a Rotor-Gene Q instrument (Qiagen) by using quantitative amplification and melting curve analysis. Results In total, 35 of 76 cases (46%) were classified as confirmed onychomycosis based on positive microscopy (M+) with or without positive culture (C+) or just by positive culture of a confirmed pathogen. Based on negative microscopy (M-) and negative culture of a confirmed pathogen, 41 cases (54%) were reported as non-fungal onychodystrophy. Agreement between DermaGenius (DG) and culture was found in 52% of the cases while 86% agreement was reported when comparing positive DG with confirmed onychomycosis. Three positive cultures (microscopy negative) were not detected by DG (2 T. rubrum, 1 C. albicans). However, DG could detect 7 additional infections (9%). Eleven discrepancies DG+/C+ were determined which could be positively confirmed in favour of DG result by ITS sequence analysis. Most discrepancies could be explained by fungal/yeast species overgrowing the agar slant, including species of Candida, Fusarium, Trichosporon, which were not considered as the source of infection. Conclusion The DermaGenius Nail plus multiplex was able to detect the most prevalent pathogenic dermatophytes species in clinical nail specimens and proved to be more sensitive and specific than culture and direct microscopy. The DNA extraction procedure has been shown to work efficiently in diagnostics which enables the physician in charge of the patient to start a dedicated treatment rapidly. [less ▲]

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See detailSofosbuvir in combination with simeprevir +/- ribavirin in genotype 4 hepatitis C patients with advanced fibrosis or cirrhosis: a real-life experience from Belgium
Moreno, C; Lasser, L; DELWAIDE, Jean ULiege et al

in Hepatology (Baltimore, Md.) (2015, October), 62(1), 746

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However ... [more ▼]

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However, efficacy and safety data of interferon-free regimens in HCV genotype 4 (G4) patients are scarce. In Belgium, Sofosbuvir (SOF) and Simeprevir (SMV) treatment is available since January 2015 for G4 patients with advanced fibrosis (F3-F4 METAVIR) for 12 weeks. Methods: analysis of HCV G4 patients receiving SOF and SMV treatment in Belgium. The aim of the study was to evaluate the safety and efficacy of the treatment. Results: 73 G4 patients were enrolled in this data collection including 32 (43.8%) patients with severe fibrosis F3 and 41(56.2%) cirrhotic patients. The study population comprised 58.9% male, 77.8% treatment experienced patients. Median age was 59 [51-66] years and 5 patients were HCV/HIV co-infected. 24 patients received the treatment associated with ribavirin, 11/32 (34.37%) of patients with advanced fibrosis and 13/41 (31.71%) of cirrhotic patients. In cirrhotic patients, median MELD and Child-Pugh score were 9 [7-12.5] and 5 [5-6], 46.2% had platelet below 100.000/mm and 28.6% had albumin below 35 g/L. W4 HCV RNA was undetectable in 31.25% (15/48). 9 of the 15 patients with undetectable W4 HCV RNA received RBV. At W12, 100% (23/23) had HCV RNA below the limit of quantification, with 6/23 still detectable. All SVR12 data will be available at the time of presentation. No patient experienced serious adverse event. Conclusions: these preliminary results in difficult-to-treat G4 HCV patients show that SOF/SIM +/- RBV treatment is safe and seems promising, in line with that was observed in G1 HCV patients. [less ▲]

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See detailA three year survey of dermatophytoses in Belgium
SACHELI, Rosalie ULiege; DARFOUF, Rajae ULiege; GRAIDE, Hélène ULiege et al

in Mycoses (2015, October), 58(Supplement 4), 135

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide ... [more ▼]

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide. Epidemiological studies regarding dermatophyte infections have been conducted in several countries and differences in the incidence and in etiological agents have been reported for different geographical areas. That is why national surveillance of circulating strains causing dermatophytosis is crucial. The Belgian National Reference Center (NRC) for Mycoses conducted a survey on dermatophytes strains circulating from 2012 to 2014. The present study was performed to assess the profile of dermatophytosis and to identify the species involved. Methods The Belgian NRC for Mycosis collected 9138 strains between January 2012 and December 2014. The isolates were cultured from patients clinically suspected for fungal infections of skin, hair and nails. Isolates were sent by Belgian laboratories to the two labs of the Belgian NRC (UZ Leuven and CHU of Liège) in order to identify the fungus or to confirm the identification. All isolates cultured from patients of UZ Leuven and CHU of Liège were also included. Fungal identification was performed by microscopy after subculture and in case of doubtful identifications by ITS sequencing. Results .Among the 9138 samples (results of UZ Leuven and CHU of Liège combined), 3587 were identified as dermatophytes. Trichophyton. rubrum (T. rubrum) was the most prevalent species accounting for 56,17% (n=2015) of the infections from all sources, followed by T. mentagrophytes complex (21,83%, n=783). The other main etiological agents of dermatophytosis recorded in this study in descending order of prevalence were M. audouinii (n=303), M. canis (n=120), T. violaceum (n=112), T. tonsurans (n= 95), T. soudanense (n=66), M. praecox (n=59), E. floccosum (n=14) Our data reveal the predominance of anthropophilic species causing tinea capitis especially M. audouinii responsible for 36,49% (n=163/448) of hair/scalp infection. Trichophyton violaceum rarely observed in our country is frequently found as 12,8% (n=57) of the reported cases of tinea capitis are due to this species. The retrospective evaluation of data collected also shows that zoophilic strains as M. canis well represented in the past epidemiology of tinea capitis, is decreasing in frequency accounting for only 7,2% (n=32) of clinical cases. Finally, our data confirm the high prevalence of T. rubrum commonly observed in Europe as causal agent of onychomycosis (70,9%, n=1603) followed by T. mentagrophytes complex (20,9%, n=455). T. rubrum and T. mentagrophytes complex are also responsible for the majority of skin infections as they represent respectively 40% (n=386) and 24,75% (n=239) of skin dermatophytosis during the study period. Conclusions The present work has provided recent data on the prevalence of several dermatophytes species circulating in Belgium. Such data is critical for the establishment of therapeutic strategies and measures for prevention and control of dermatophytes infections. Our study confirms the predominance of T. rubrum followed by T. mentagrophytes in the Belgian population but also highlights the emergence of new anthropophilic species such as M. audouinii and T. violaceum as causative agents of tinea capitis in children in relation with African immigration. [less ▲]

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See detailEpidemiological aspects and genotypic characterization of T.violaceum strains collected during a Belgian National survey on anthropophilic tinea
SACHELI, Rosalie ULiege; Dekkers, Charlotte; GRAIDE, Hélène ULiege et al

in Mycoses (2015, October), 58(Supplement 4), 189

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the ... [more ▼]

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the population, the Belgian National Reference Center (NRC Liège) launched a one-year national survey in 2013. Epidemiological aspects and genotypic characterization of the strains were included. Methods The study was conducted from March 2013 up to February 2014. All Belgian laboratories were asked to send M. audouinii and T. violaceum strains isolated from hair to the NRC with a form to fill in including epidemiological data. The fungal strains were identified by microscopy or ITS sequencing in case of doubtful identification. The genotypic analysis was performed by the DiversiLab® system (bioMérieux) for DNA fingerprinting and analysis. Epidemiological data were analyzed with the help of a biostatistician. Results Amongst the collected isolates, 23 strains were confirmed as T.violaceum (results concerning the 116 M. audouinii strains have already been reported). Analysis of the epidemiological characteristics of the infected population shows that the main age category concerns 0-4 year-old children (n=9, 39,1%) with a sex-ratio M/F of 1.875. Data concerning the geographic origin of the family were present in 82,6% of the cases and reveal that patients were mainly of Ethiopian origin (n=8, 57,9% of known cases). One patient was also from Burundi showing that T. violaceum strains probably circulate mainly in East Africa. The genotypic analysis led to the distinction of 2 variants of T. violaceum. The major group was composed of 17 strains which were mainly collected in the North of Belgium and included also the reference strain (18/23, 83,3%). The other group (6 strains) was close to the major group but the analysis of the spectral superposition showed some differences between these two groups, defining two distinct variants of T. violaceum in the Belgian population. This second variant was mainly recovered from South Belgium (5/6, 83,3%). No correlation could be made between the genotypic group and a particular ethnical origin as Ethiopian subjects were found in both groups. Conclusion The DiversiLab® system proved to be an efficient method to investigate the molecular epidemiology of dermatophytes infections as reported previously for M. audouinii. These results show that two distinct isolates co-exist in Belgium providing evidence of genetic heterogeneity and a possible spread of one genotypic variant in a restricted geographic area or the co-existence of two variants circulating in different African communities. However, no clear correlation could be established between the appartenance to a group and epidemiological factors, such as age or ethnical origin. [less ▲]

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See detailUsing S-Monovette° lower the rate of hemolysed specimen from a belgian academic emergency department
VRANKEN, Laura ULiege; DELCOUR, Sandra ULiege; CAVALIER, Etienne ULiege

in Clinical Chemistry & Laboratory Medicine (2015, October)

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