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See detailThe Immunomodulating Peptide Thymosin Alpha 1 Has no Effect on Multiple Myeloma Evolution and on Immune Reconstitution
Binsfeld, Marilène ULg; Otjacques, Eléonore ULg; Hannon, Muriel ULg et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 41

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See detailOleuropein or rutin consumption decreases the spontaneous development of OA in Hartley guinea pig
Sanchez, Christelle ULg; Horcajada, Marie-Noëlle; Membrez, Fanny et al

in Arthritis and Rheumatism (2013), 65

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See detailGenetics of body energy status of Holstein cows predicted by mid-infrared spectrometry
Bastin, Catherine ULg; Berry, D.; Gengler, Nicolas ULg et al

in Journal of Dairy Science (2013), 96(E-Suppl. 1),

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See detailVisean corals from the transverse Jebel Begaa to Gara el Itima (eastern Tafilalt, Morocco)
Aretz, Markus; Denayer, Julien ULg

in Document de l'Institut Scientifique, Rabat (2013), 26

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See detailBiofilm formation on metal structured packing for the production of high added value biomolecules
Zune, Quentin ULg; Zune, Quentin ULg; Toye, Dominique ULg et al

in Récents Progrès en Génie des Procédés (2013)

Many white biotechnology bioprocesses apply techniques from chemical engineering based on bioreactors with mechanical stirring system commonly employed in pharmaceutical sector, food industry or energy ... [more ▼]

Many white biotechnology bioprocesses apply techniques from chemical engineering based on bioreactors with mechanical stirring system commonly employed in pharmaceutical sector, food industry or energy field (Dasilva, 2004). As in chemical engineering, scale-up of these bioprocesses induces physicochemical constraints that affect physiological pathways and decrease performances. In this context, it is essential to think new bioprocesses better suited to physiology of microorganisms, minimizing physicochemical constraints. The aim of this work consists to use stainless steel structured packing (SSP) with high specific area (500-750 m²/m³) as inert support for biomass immobilization in order to produce high added value biomolecules. These bioreactors are biocatalysts in which microbial system is immobilized biomass on the form of a biofilm performing bioconversion of a substrate into a specific product (Rosche, 2009). In this study, an experimental setting containing a SSP reproduces solid-state fermentation (SSF) like conditions. Two well known microorganisms for their ability to form biofilm and secrete metabolites are tested in the experimental setting : Bacillus subtilis for its lipopeptides and Aspergillus oryzae for its glucoamylase. Effectiveness of the bioprocess in term of dynamic of the excretion of the target biomolecule is compared with a classical submerged culture (SmF). For lipopeptides production from B. subtilis, SSP is located in a 20L bioreactor continuously aspersed by liquid medium required to the growth of the biofilm. In the case of A. oryzae, the SSP is partially immerged in a 250 mL shake flask. X-ray tomography of the SSP allows non-invasive visualization and quantification of biofilm repartition inside the support. Implementation of SSP permits almost total immobilization of biomass on the form of a mono-species biofilm to the detriment of the liquid phase. Processing of images obtained by X-ray tomography of the SSP provides relevant information for the optimization of the bioprocess. For both microorganism species, results indicate the influence of parameters such as hydrodynamics, aeration rate and microorganism specificity, on the biofilm morphology inside the support and the performances of the bioprocess. SSF-like conditions in the experimental setting lead to technologic progress, such as absence of foam formation, persistence of the microbial system, and improve the dynamic of metabolites excretion compared with conditions imposed by the submerged culture. Further experiment will consider hydrodynamics aspects and amount of carbon source on effectiveness of the bioprocess. [less ▲]

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See detailOptimizing scale search in species distribution models
Serckx, Adeline ULg; Huynen, Marie-Claude ULg; Beudels-Jamar, Roseline et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of ... [more ▼]

The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of global change. In many studies the influence of a predictor on a response derived over multiple and discrete spatial scales is evaluated. Due to inherent issue of multiple testing, this approach can be problematic. In this study on bonobos distribution, we suggest a 3-steps procedure that overcomes this problem. It takes into account the decay of a predictor by using a weighting function of distance to the observation of interest. We use variables to account for human pressure, food availability, patchy structure of the forest and nesting sites re-use. In a first step, we run a model with a fixed scale for every predictor based on expert opinion. For significant variables, we derive then in a second step the distance weighted influence over a range of scales. This helps to narrow down the search for the final model parameter estimates. Findings indicate that bonobo distribution is driven on the intermediate scale by forest patches structure. Food availability explains their abundance only at smaller scales. Those results demonstrate the sadly well-known influence of habitat fragmentation on animals’ density and distribution but also highlight the importance to understand influences of scale, the animal perceptions of their environment, by using appropriate statistical procedures. Our method can be particularly useful to formulate specific management hypotheses for conservation. Furthermore, its principles can be of use to other types of studies, such as behavior. [less ▲]

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See detailDes ambassadeurs entre Liège et Bourgogne: Pour une étude des relations diplomatiques des pouvoirs liégeois avec les ducs Valois
Masson, Christophe ULg

in Publication du Centre Européen d'Etudes Bourguignonnes (2013), LIII(2013), 51-66

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See detailComparison of Immune Reconstitution after Hematopoietic Stem Cell Transplantation with Flu-TBI versus TLI-ATG Conditioning
Hannon, Muriel ULg; Humblet-Baron, S.; Graux, C. et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 38

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See detailStudy on the sensitivity of three oat varieties to the saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae)
Censier, Florence ULg; Chavalle, Sandrine; San Martin y Gomez, Gilles et al

in Communications in Agricultural and Applied Biological Sciences (2013), 78

The saddle gall midge, Haplodiplosis marginata (von Roser, 1840) is a univoltine pest of cereals which occurs in Europe. The larvae feed on stems and attractive saddle-shaped depressions, driving to ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser, 1840) is a univoltine pest of cereals which occurs in Europe. The larvae feed on stems and attractive saddle-shaped depressions, driving to important yield losses when the galls are numerous. After 40 years without any reporting, large populations of H. marginata and important damage have been observed since 2010 in wheat crops in Belgium, especially in the Flemish Polders where clay soils and intensive farming of cereals favour heavy infestations. According to some research conducted in the 1960s during the last outbreak, oat (Avena sativa L.) is known to be one of the less favourable hosts to the saddle gall midge. Our study was performed in order to assess the host sensitivity of three oat varieties currently grown in Belgium: EVITA, EFFEKTIV and FREDDY. Therefore, oat varieties were sown on infested soil in two separate enclosures in a glasshouse. In the first enclosure, only the three oat varieties were grown; in the second one, these three oat varieties were grown together with two varieties of spring wheat: GRANNY and KWS CHAMSIN. Two parameters were measured: the percentage of leaves with laid eggs, and the number of galls per stem. The percentage of leaves with eggs showed that the infestation was significantly lower on oats when they were in presence of wheat. The egg infestation was also significantly higher on wheat than on oat, which means oat is a much less favourable host plant than spring wheat for egg laying. Oat varieties were significantly different from each other regarding the number of galls per stem, but with very little damage compared to wheat. The FREDDY variety even seemed to be completely resistant to saddle gall midge, as no galls were observed although there was a similar percentage of leaves with eggs for the three oat varieties. Cropping oat could thus contribute to reduce infestations of H. marginata. [less ▲]

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See detailThe Enhancement of Secondary Succession by Western Lowland Gorillas (Gorilla gorilla gorilla) in a Moist Tropical Forest of Southeast Cameroon
Petre, Charles-Albert ULg; Haurez, Barbara ULg; Tagg, Nikki et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailBehavioural Ecology of Bonobos (Pan paniscus) in the Forest-Savannah Mosaics of Western Democratic Republic of Congo
Vimond, Marie; Serckx, Adeline ULg; Beudels-Jamar, Roseline et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013)

The long-term survival of the Endangered bonobo (IUCN, 2012) will depend on well thought out conservation programmes that need to be built both upon the species’ ecological requirements and local socio ... [more ▼]

The long-term survival of the Endangered bonobo (IUCN, 2012) will depend on well thought out conservation programmes that need to be built both upon the species’ ecological requirements and local socio-economics realities. Yet there is still a lot to find out, including information on the species geographical distribution. In 2005, the presence of a western population was confirmed in the forest-savannah mosaic in the south-western part of the Lake Tumba Landscape. With the exception of an early study carried out in Lukuru, the species is mainly known from lowland rainforest research sites in the Cuvette Centrale. The western forest-savannah mosaic is an ecotone with a marked seasonal pattern, a high variability of habitats and monthly variations in fruit production. All this leads to spatio-temporal variation of food availability. In order to increase studies and monitoring of this unique population, WWF initiated a habituation process of two groups of bonobos 6 years ago. The groups are now semi-habituated, making the collection of direct daily observations possible. Our objective is to describe the behavioural strategies developed by this population in order to cope with spatio-temporal variations of food availability. This will be approached by identifying daily activity, ranging and grouping patterns, in order to understand how they affect social structure. It should also allow us to define the use of savannahs. Our findings will help determine specific conservations measures for this endangered species. [less ▲]

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See detailAnalysis of $\alpha_s$ from the realization of quark-hadron duality
Courtoy, Aurore ULg; Liuti, Simonetta

in World Scientific (2013)

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See detailInhibition de la sclérostine par le romosozumab chez des femmes ménopausées ayant une DMO basse : résultats de l'étude de phase 2
Brown, JP; McClung, MR; Grauer, A et al

in Revue du Rhumatisme (2013), 80(S1), 73

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See detailPotential of mid-infrared spectrum of milk to detect changes in the physiological status of dairy cows
Laine, Aurélie ULg; Goubau, Amaury; Hammami, Hedi ULg et al

in Journal of Dairy Science (2013)

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See detailFirst steps towards an explicit modeling of aba production and translocation in relation with the water uptake dynamics
Lobet, Guillaume ULg; Pagès, Loic; Draye, Xavier

in Acta Horticulturae (2013), 991

Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act ... [more ▼]

Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act as a switch in the water flow, even under high transpiration demand. The control of the stomatal aperture by the plant has been the object of numerous research projects since decades and different models have been developed to study stomatal regulation. The plant hormone abscisic acid (ABA) produced in the leaves acts as an endogenous signal triggering stomatal closure, but is also thought to act as a long distance signal that is produced by roots experiencing water deficit. However, the relative contributions of leaf-supplied ABA, root-supplied ABA and xylem water potential in the regulation of water flow remains a matter of controversy. Using a novel functional structural plant model (PlaNet-Maize-ABA), we report here a first attempt to explicitly simulate ABA production, degradation, translocation in all plant organs and their effect on the transpiration flow. [less ▲]

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See detailHydrological and geopedological dynamics of a forested slope
Deraedt, Deborah ULg; Degré, Aurore ULg; Colinet, Gilles ULg

in Geophysical Research Abstracts (2013), 15

Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the ... [more ▼]

Though forested watersheds are really particular in terms of hydrodynamics, most of the hydrological models oversimplify the phenomena involved. More investigations are unavoidable to improve the knowledge and the modelling of this environment. Here is the aim of this study. The studied slope is located on the Houille watershed in the West of the Belgian Ardenne (50 1’47”N, 4 53’22”E) on a silty rocky soil. The site is situated under a Douglas fir (Pseudotsuga menziesii (MIRB.) FRANCO) and spruce stand cover (Picea abies (L.) Karst). It is about 160 meters long with a North-West facing slope between 7 and 55%. The goal of the study is : - to characterise the hydrological and pedogeological dynamics along a forested slope, - to compare these dynamics with the tree growth. For the geopedological part of the study, eight pits were dug to describe the soil and take some soil samples used for granulometric, chemical, etc. analysis. We have used geophysical methods (Electrical Resistivity Tomography and Ground Penetrating Radar) to estimate the soil depth. As for the hydrological part of this study, moisture sensors (capacitive and TDR) have been installed in the pits along the slope. A dye tracing test has been performed to underline the preferential flow and the importance of the subsurface flow. Several trees have been equipped with dendrometers and some measures of the LAI and the height of the trees are planned. [less ▲]

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See detailModeling of non-covalent complexes of the cell-penetrating peptide CADY and its siRNA cargo
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Deshayes, Sébastien et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 63

CADY is a cell-penetrating peptide spontaneously making non-covalent complexes with short interfering RNAs (siRNAs) in water. Neither the structure of CADY nor that of the complexes is resolved. We have ... [more ▼]

CADY is a cell-penetrating peptide spontaneously making non-covalent complexes with short interfering RNAs (siRNAs) in water. Neither the structure of CADY nor that of the complexes is resolved. We have calculated and analyzed 3D models of CADY and of the non-covalent CADY–siRNA complexes in order to understand their formation and stabilization. Data from the ab initio calculations and molecular dynamics support that, in agreement with the experimental data, CADY is a polymorphic peptide partly helical. We calculated and compared several complexes with peptide/siRNA ratios of up to 40. The initial binding of CADYs is essentially due to the electrostatic interactions of the arginines with siRNA phosphates. Due to a repetitive arginine motif (XLWR(K)), CADYs can adopt multiple positions at the siRNA surface. Nevertheless, several complex properties are common: an average of 14 ± 1 CADYs is required to saturate a siRNA. The 40 CADYs/siRNA that is the optimal ratio for vector stability always corresponds to two layers of CADYs per siRNA and the peptide cage is stabilized by hydrophobic CADY–CADY contacts. The analysis demonstrates that the hydrophobicity, the positive charges and the polymorphism of CADY are mandatory to make stable the CADY–siRNA complexes. [less ▲]

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See detailLe ranélate de strontium diminue la proportion de patients progressant rapidement dès la première année : une analyse post hoc de l'étude SEKOIA
Chevalier, X; Richette, P; Bruyère, Olivier ULg et al

in Revue du Rhumatisme (2013), 80(S1), 59-60

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See detailReduction in VAP incidence by subglottic secretion drainage and antibiotic consumption in ICU patients
VAN CAUWENBERGE, Isabelle ULg; ANCION, Arnaud ULg; LAMBERMONT, Bernard ULg et al

in Intensive Care Medicine (2013), 39(Suppl 2), 465-4660898

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See detailExtension of the Liège Intra Nuclear Cascade model to light ion-induced collisions for medical and space applications
Leray, S.; Mancusi, D.; Kaitaniemi, P. et al

in Journal of Physics: Conference Series (2013), 420

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See detailA new method for computing the derivatives of the mean and amplitude of physiological variables with respect to the parameters of a cardiovascular system model
Pironet, Antoine ULg; Dauby, Pierre ULg; Revie, James A. et al

in Minimally Invasive Therapy & Allied technologies : Official Journal of the Society for Minimally Invasive Therapy (2013), 22

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See detailQUASI-STATIC MECHANICAL BEHAVIOUR OF TI-6AL-4V ALLOY AT ROOM TEMPERATURE
Tuninetti Vásquez, Victor ULg; Gilles, Gaëtan ULg; Milis, Olivier ULg et al

in Complas XII (2013), XII

In order to determine the mechanical behavior of a bulk TA6V alloy, a set of mechanical tests such as shear, compression, tensile monotonic tests, and tensile tests on notched samples are performed. The ... [more ▼]

In order to determine the mechanical behavior of a bulk TA6V alloy, a set of mechanical tests such as shear, compression, tensile monotonic tests, and tensile tests on notched samples are performed. The material is tested at constant strain rate. Full-field optical technique for displacement measurements and strain computation are used for all the experiments. Plastic anisotropy and tension–compression asymmetry are observed. The CPB06 [1] yield criterion adapted for hexagonal close packed (hcp) material is identified. The sensitivity of the material parameters on the identification method as well as the efficiency of the model to predict forces and displacement field are discussed. Validation is done by using Finite Element method (FEM) simulations and 3D Digital Image Correlation (3D-DIC) measurements on specimens with multi-axial stress and strain fields subjected to large deformation. [less ▲]

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See detailBlood lead, urinary lead, urinary δ-aminolevulinic acid and urinary porphyrins levels among people living in kinshasa, D.R. Congo : a pilot biomonitoring study
Mputu Malolo, Corneille-Liévin; Ndelo di Phanzu, Josaphat; Marini Djang'Eing'A, Roland ULg et al

in Acta Clinica Belgica (2013), 68(6), 475

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See detailSurface and lipid interaction properties of novel rhamnolipids to explain their eliciting activity
Nasir, Mehmet Nail ULg; Monhonval, Pierre; Nott, Katherine ULg et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 168

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See detailIdentifying early Earth microfossils in unsilicified sediments
Javaux, Emmanuelle ULg; Asael, Dan; Bekker, Andrey et al

in Geophysical Research Abstracts (2013), 15

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See detailSiblings and coming-out
Haxhe, Stéphanie ULg; D'Amore, Salvatore ULg

in Psychology, Community & Health (2013), 2(2), 162

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See detailRisk factors for atrial fibrillation and ventricular tachyarrhythmias in 3499 equids admitted at the liege university equine hospital between 1994 and 2011
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Proceedings of the 2013 ECEIM Congress (2013)

Risk factors for atrial fibrillation (AF) and pathological ventricular tachyarrhythmias (VTA) have been suspected in equids, however little epidemiologic data exists. The aim of this study was to ... [more ▼]

Risk factors for atrial fibrillation (AF) and pathological ventricular tachyarrhythmias (VTA) have been suspected in equids, however little epidemiologic data exists. The aim of this study was to determine risk factors for AF and VTA in a large equine population. Case files of 3499 equids admitted to the internal medicine department of the Liege University Equine Teaching Hospital between 1994 and 2011were reviewed. Amongst them, 495 horses with a suspicion of a cardiac abnormality underwent ECG and echocardiography. After calculation of prevalence of AF and VTA, we tested whether breed (chi-square test) or gender, age, body weight (BW) and presence of other cardiac diseases (logistic regressions) were risk factors (significance set at p<0.05). In the studied population, prevalence of AF was high (2.3%), whereas prevalence of VTA was low (0.7%). Warmbloods and standardbreds were significantly overrepresented in AF cases. High BW was a risk factor for AF (OR=3.54; CI=1.67-7.49), whereas age was not. No effect of breed, age or BW was demonstrated for VTA. AF was observed significantly more frequently in horses presenting with moderate to severe mitral regurgitation (MR), tricuspid regurgitation, and pulmonary regurgitation, and VTA was significantly more frequent in horses with MR. Several previously suspected but not statistically demonstrated risk factors of AF were confirmed in this study and horses presenting valvular disease could be at increased risk of developing AF and VTA. [less ▲]

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See detailProcessing of Ti alloys by additive manufacturing: a comparison of the microstructures obtained by laser cladding, selective laser melting and electron beam melting
Reginster, Sylvie ULg; Mertens, Anne ULg; Paydas, Hakan ULg et al

in Materials Science Forum (2013), 765

Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the ... [more ▼]

Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the restoration - of complex and (almost) fully dense parts from Ti alloys. Both techniques involve the melting of a metallic powder with a laser. In the SLM process, the metallic powder is deposited layer by layer in a powder bed and then molten locally according to the desired shape, whereas in LC, the metallic powder is directly projected onto a substrate through a nozzle coaxial with the laser beam. The present research aims at comparing Ti-6Al-4V samples processed by these two techniques with reference samples produced by electron beam melting (EBM), another well established additive manufacturing process (patented by Arcam AB Company) in which a powder bed is molten locally by means of an electron beam. In all three processes, the melt pool undergoes an ultrafast cooling and solidifies very rapidly once the beam has left the area, thus giving rise to strongly out-of-equilibrium microstructures. Yet, each one of these processes also has its own specificities e.g. in terms of scanning strategy and of working atmosphere (low vacuum vs. protective Ar flow). In the present work, the microstructures obtained by these three processes have been compared in details, with a particular attention for characteristics such as porosity, grain size, and the various phases present. Since epitaxial growth of the newly deposited layer on the material previously solidified has been shown [1, 2] to exert a strong influence on the microstructure and on the resulting mechanical properties, great care has been taken to study the microstructural anisotropy associated with each one of the three processes. [less ▲]

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Journal of Psychophysiology (2013), 27(Suppl 1), 48

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See detailAltered cartilage phenotype in mice lacking Sirt-1 gene
Gabay, Odile; Zaal, K; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2013), 21

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women
Reginster, Jean-Yves ULg; Ellis, AG; Luo, X et al

in Osteoporosis International (2013), 24(1), 37

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See detailSystemic Active and Total Myeloperoxidase Levels in Coronary Artery Disease.
GACH, Olivier ULg; MAGNE, Julien ULg; Franck, Thierry ULg et al

in Cardiology (2013), 126(Suppl. 2), 1-521

Backgound: Measurement of total Myeloperoxidase (MPO) by ELISA is considered as a marker of neutrophil activation but is not the true indicator of the degree of its activity. In a dynamic pathology such ... [more ▼]

Backgound: Measurement of total Myeloperoxidase (MPO) by ELISA is considered as a marker of neutrophil activation but is not the true indicator of the degree of its activity. In a dynamic pathology such as atherosclerosis, it may be important to measure the real active part of MPO because it represents the true witness of the oxidant potential of the enzyme. Aim: To identify the relation between coronary artery disease identified by coronaro-angiography on measured serum total and active MPO levels and evaluate the correlation between these MPO levels and the presence of clinically defined unstable condition. Methods: Prospective analyse of serum samples of patients before (within 30 min) coronaro-angiography. Total and active MPO concentrations were assessed by sandwich Elisa and SIEFED® method’s respectively. Results: Two hundred and twenty patients were included in this study (age: 66.1±10.7 years, 67% of male). Among these, 62% presented significant coronary artery disease (stenosis more than 60% at least in one épicardial coronary artery). Twenty four patients (11%) presented unstable coronary syndrome. Mean active and total MPO in the general population were 50.1±63.5 and 147.6±223.3 ng.mL-1 respectively. In comparison, mean active MPO was 47.1±47.9 ng.mL-1 in stable patients and 75.1±135.2 ng.mL-1 in unstable patients (p=0.04). Mean total MPO was 146.3±224.7 ng.mL-1 in stable patients and 158.2±215.8 ng.mL-1 in the unstable’s one (p=0.8). There was a significant correlation between active MPO levels and instability (r=0.14, p=0.04) not present for total MPO levels (r=0.016, p=0.8). Conclusion: We observed a correlation between active MPO and clinical instability while there was no correlation with total MPO. Our preliminary results suggest that this marker could be a powerful indicator of instability which could possess an important prognostic impact. This hypothesis requires an evaluation in wider population and during a prolonged follow-up. [less ▲]

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See detailFinal analysis of overall survival for the Phase III CONFIRM trial: fulvestrant 500 mg versus 250 mg
DI LEO, Angelo; JERUSALEM, Guy ULg; PETRUZELKA, Lubos et al

in Cancer Research. Supplement (2012, December 15), 72(24), 1-4

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See detailDiscriminant BOLD Activation Patterns during Mental Imagery in Parkinson’s Disease
Schrouff, Jessica ULg; Cremers, Julien ULg; D'Ostilio, Kevin ULg et al

in Proceedings of MLINI 2012 (2012, December 07)

Using machine learning based models in clinical applications has become current practice and can prove useful to provide information at the subject’s level, such as predicting an (early) diagnosis or ... [more ▼]

Using machine learning based models in clinical applications has become current practice and can prove useful to provide information at the subject’s level, such as predicting an (early) diagnosis or monitoring the evolution of a disease. However, the performance of these models depends on the choice of a biomarker to detect the presence or absence of a disease. Choosing a biomarker is not straightforward, especially in the case of Parkinson’s disease when compared to healthy subjects. In the present work, we investigated the mental imagery of gait as a biomarker of Parkinson’s disease and showed that the signal in the mesencephalic locomotor region during the mental imagery of gait at a comfortable pace can discriminate significantly between idiopathic Parkinson’s disease patients and healthy subjects. Although there is room for improvement, the results of this preliminary study are promising. [less ▲]

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See detailInnovative Surface Plasmon Resonance biosensing architectures
desfours, Caroline; Hastanin, Juriy ULg; Drucbert, Anne-Sophie et al

in International Conference on Fibre Optics and Photonics (2012, December)

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological ... [more ▼]

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological molecules with a two-wavelength sensor and a SPR Coupler- Disperser spectroscopic sensor. [less ▲]

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See detailMeasurement of serum albumin by protein electrophoresis and bromocresol green methods in canine and equine patients
Ramery, Eve ULg; Bureau, Fabrice ULg

in Veterinary Clinical Pathology (2012, December), 41(4), 5

Background: Bromocresol green method (BCG) is routinely used in veterinary laboratories to measure albumin. A good agreement between BCG and electrophoresis (SPE) in healthy domestic animals is reported ... [more ▼]

Background: Bromocresol green method (BCG) is routinely used in veterinary laboratories to measure albumin. A good agreement between BCG and electrophoresis (SPE) in healthy domestic animals is reported. However, in human medicine, at low albumin and high globulin concentrations, BCG also binds to α- and β-globulins fractions. Surprisingly, there is no recent literature evaluating the BCG method in diseased domestic animals. Objective: The purpose of the present study was therefore to compare the serum albumin values obtained by SPE and BCG in canine and equine patients. Methods: Albumin measured by BCG and SPE was compared in the serum from 30 canine and 30 equine patients. Results: Good correlation was found (Spearman´s rho rs = 0.91 in dogs and 0.84 in horses). However, Altman and Bland analysis of results showed a positive bias of BCG with SPE (3.41 g/l in horses and 0.41 g/l in dogs) that increased when only hypoalbuminemic patients were considered (4.17 g/l in horses and 1.31 g/l in dogs). Conclusion: Results confirm that, despite good correlation, BCG method tends to overestimate albumin, especially in hypoalbuminemic patients. This is particularly evident in horses. [less ▲]

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See detailPotentiel de dispersion du sanglier et historique de la colonisation de la plaine agricole
Morelle, Kevin ULg; Prévot, Céline

in Forêt Wallonne (2012, December), 121

Les populations de sangliers augmentent en nombre et étendent leur aire de répartition un peu partout en Europe. En Wallonie, la population de sangliers a quadruplé en 30 ans. Plusieurs études se sont ... [more ▼]

Les populations de sangliers augmentent en nombre et étendent leur aire de répartition un peu partout en Europe. En Wallonie, la population de sangliers a quadruplé en 30 ans. Plusieurs études se sont penchées sur le sujet et les raisons de cette augmentation concernent souvent l’influence du climat. Grâce aux différents suivis réalisés par le DEMNA, les déplacements au sein des populations de sangliers sont mieux compris. L’article se penche d’abord sur le potentiel de dispersion du sanglier en se basant sur les données de bagage de marcassins. Deux variables sont analysées : la distance parcourue dans le cadre de la dispersion natale (mouvement à sens unique à partir du site de naissance d’un individu jusqu’à son site de première reproduction) et le taux de cette dispersion natale. Quelques résultats provenant d’une étude génétique sont également présentés. Le génotypage de 1153 sangliers répartis sur l’ensemble de la Wallonie a mis en évidence quatre sous-populations génétiquement homogènes. Parallèlement à l’augmentation de la taille de ses populations, le sanglier a vu son aire de distribution s’accroître en Wallonie. Un suivi par enquête a été réalisé auprès des conseils cynégétiques et des agents du DNF pour mieux comprendre l’expansion géographique observée. Une première phase de l’enquête visait à retracer l’expansion géographique du sanglier en Wallonie. La seconde phase consistait à réaliser un état des lieux sur la situation actuelle de la distribution du sanglier en périphérie du sillon Sambre-et-Meuse. [less ▲]

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See detail(Pré)textes : perspective didactique sur le dépeçage des textes littéraires à des fins d'exemplification
Van Beveren, Julien ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2012, December), 4

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See detailUne étude de la vulnérabilité cognitive des parents au premier degré de patients schizophrènes
Wagener, Aurélie ULg; Duke, Géraldine; Xhenseval, Laure et al

in Revue Francophone de Clinique Comportementale et Cognitive (2012, December), XVII(4), 53

Schizophrenic patients and their first-degree relatives suffer from cognitive deficits in different area (memory, executive, attentional and language functions) which allows us to consider these deficits ... [more ▼]

Schizophrenic patients and their first-degree relatives suffer from cognitive deficits in different area (memory, executive, attentional and language functions) which allows us to consider these deficits as endophenotypes of schizophrenia. Schizophrenic patients also suffer from a lack of autobiographical memory and instability of identity: our study aims to determine whether this deficit and this instability are endophenotypes of schizophrenia. In order to reach this objective, we evaluated first-degree relatives. The results show that first-degree relatives suffer from cognitive deficits but, contrary to our hypotheses, not any deficit of specificity or instability of identity have been highlighted among these parents. [less ▲]

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See detailEvaluation d'un protocole de prise en charge nutritionnelle interdisciplinaire chez des patients brulés
MALHERBE, Christian ULg; VERBRUGGE, Anne-Marie ULg; MAGNETTE, André ULg et al

in Nutrition Clinique et Metabolisme (2012, December), 26-Supp1

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See detailUse of medium without reducing agent for in vitro fermentation studies by bacteria isolated from pig intestine
POELAERT, Christine ULg; Boudry, Christelle ULg; Portetelle, Daniel ULg et al

in Journal of Animal Science (2012, December), 90(Supplement 4), 387-389

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See detailDynamic simulations of solar combisystems integrating a seasonal sorption storage: Influence of the combisystem configuration
Hennaut, Samuel ULg; Thomas, Sébastien ULg; Davin, Elisabeth ULg et al

in Strojarstvo: Journal for Theory and Application in Mechanical Engineering (2012, December), 54(6), 433-440

This paper focuses on the sizing of solar combisystems with adsorption seasonal storage to target autonomous solar space heating. Two main configurations of the combisystem are simulated, including one or ... [more ▼]

This paper focuses on the sizing of solar combisystems with adsorption seasonal storage to target autonomous solar space heating. Two main configurations of the combisystem are simulated, including one or two tanks. The influence of the seasonal storage on the sizing of the tanks is also discussed. Results show that performances of the system with two tanks are better (2 to 4 % with seasonal storage) but some improvements should be possible for the single tank configuration. The sizing of the sensible storage is nearly independent of the solar collectors area if there is a seasonal storage. The sensible storage size increase with the collectors area without adsorption storage. The analysis is conducted in simulation using the TRNSYS program. [less ▲]

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See detailNon-thermal radiation from a runaway early-type star
del Valle, M.; Romero, G.E.; De Becker, Michaël ULg

in AIP Conference Proceedings (2012, December), 1505

HD 195592 is an O-type supergiant star, known as a well-established runaway. Recently, a Fermi γ-ray source (2FGL J2030.7+4417) with a position compatible with that of HD 195592 has been reported. Our ... [more ▼]

HD 195592 is an O-type supergiant star, known as a well-established runaway. Recently, a Fermi γ-ray source (2FGL J2030.7+4417) with a position compatible with that of HD 195592 has been reported. Our goal is to explore a scenario where HD 195592 is the counterpart of the Fermi γ-ray source. The high-energy emission would be inverse Compton radiation produced in the bowshock of the runaway star. We calculate relativistic particle energy losses and the resulting radiation from the bowshock of HD 195592 and show that the latter is compatible with the detected γ-ray emission. We conclude that the Fermi source 2FGL J2030.7+4417 might be produced, under some energetic assumptions, by inverse Compton up-scattering of infrared photons from locally heated dust. HD 195592 might therefore be the very first object detected belonging to the category of γ-ray emitting runaway massive stars, whose existence has been recently predicted. [less ▲]

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See detailPatterns of Clinical Management and Resource Utilisation for Postmenopausal Hormone-Receptor-Positive HER2-Negative (HR+ HER2-) Advanced Breast Cancer (BC) in Europe
ANDRE, Fabrice; MARINSEK, Nina; RICCI, Jean-François et al

in Value in Health (2012, November), 15(7), 419

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See detailVocal Impact of a Prolonged Reading Task in Dysphonic versus Normophonic Female Teachers
Remacle, Angélique ULg; Morsomme, Dominique ULg; Berrué, Elise et al

in Journal of Voice (2012, November), 26(6), 8201-82013

OBJECTIVES: This study evaluates the impact on voice of a 2-hour reading task between 70-75 dB(A) in 16 normophonic and 16 dysphonic female teachers with vocal nodules. METHODS: Objective measurements ... [more ▼]

OBJECTIVES: This study evaluates the impact on voice of a 2-hour reading task between 70-75 dB(A) in 16 normophonic and 16 dysphonic female teachers with vocal nodules. METHODS: Objective measurements (acoustic analysis, voice range measurements, aerodynamic measurements) and subjective self-ratings were collected before the task and every 30 minutes during the reading to determine the voice evolution in both groups. RESULTS: Fundamental frequency, lowest frequency, highest frequency (F-High), highest intensity and intensity range increase through the reading, whereas Shimmer decreases. Maximum phonation time decreases after 30 minutes. Estimated subglottal pressure (ESP) and sound pressure level increase during the first hour. Afterwards, ESP decreases. Self-ratings worsen through time. When comparing the normophonic and the dysphonic teachers, self-ratings reveal more complaints in the dysphonic group. Few differences in objective measurements are found between both groups: normophonic teachers show lower ESP, higher F-High and greater frequency range. CONCLUSIONS: Frequency modifications from acoustic analysis and voice range measurements suggest an increased laryngeal tension during vocal load, while subjects perceive a worsening of voice. Aerodynamic parameters depict first a deterioration of voice efficiency and then an adaptation to the prolonged reading. The comparison between both groups shows a discrepancy between objective measurements and self-ratings, suggesting that both approaches are necessary to have a complete view of vocal load effects. Surprisingly, both groups behave similarly through vocal load, without more or quicker deterioration of voice in the dysphonic group. [less ▲]

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See detailHighly excited states of baryons in large Nc QCD
Matagne, Nicolas; Stancu, Floarea ULg

in Bled Workshops in Physics (2012, November), 13(1), 47-53

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See detailWhat is the potential increase of the heart graft pool by cardiac donation after circulatory death?
NOTERDAEME, Timothée; NELLESSEN, Eric ULg; HANS, Marie-France ULg et al

in Transplantation (2012, November), 94

Background: Heart transplantation remains to date the only definite treatment option for end-stage heart diseases. Currently only heart procured from brain death (DBD) donors are used. Combined with an ... [more ▼]

Background: Heart transplantation remains to date the only definite treatment option for end-stage heart diseases. Currently only heart procured from brain death (DBD) donors are used. Combined with an increasing demand, the constant heart graft shortage leads to an increase of deaths on cardiac transplantation waiting lists. The use of hearts procured after donation after circulatory death (DCD) could help to partly decrease the heart graft shortage. The aim of this study was to evaluate the potential increase of heart graft pool by development of DCD heart transplantation. Methods: The authors retrospectively reviewed their local donor database for the period 2006-2011, and screened the complete controlled DCD donor population for potential heart donors, using the same criteria as for DBD heart transplantation. The acceptable warm ischemic time (WIT) was limited to 30min from life support withdrawal to aortic cannulation. Results: During the analyzed timespan, 177 DBD and 70 DCD were effectively performed. From the 177 DBD, a total of 70 (39.5%) hearts were procured and transplanted locally or in another center. Out of the 70 DCD, 8 (11%) donors fulfilled the criteria for heart graft procurement and had a WIT of less than 30 minutes. During the same period, 82 patients were newly listed for heart transplantation, of which 53 were transplanted, 20 died or were unlisted, and 9 were still awaiting transplantation. Conclusions: Based on our database and a WIT of less than 30min, it could be estimated that 11% of the DCD might be heart graft donors, representing a 11% increase in heart graft procurement, as well as potential reduction of the deaths on the waiting list by 40%. [less ▲]

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See detailPrognostic Value of Serologic and Histologic Markers on Clinical Relapse in Ulcerative Colitis Patients With Mucosal Healing
Bessissow, Talat; Lemmens, Bart; Ferrante, Marc et al

in American Journal of Gastroenterology (2012, November), 11(107), 1684-92

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See detailEvaluation de l’impact de la filiere de production porcine sur les caractéristiques des jambons de l’IGP (Indication Géographique Protégée) Jambon d’Ardenne
Dzaomuho-Lenieregue, Phidias ULg; Eloundou Mballa, Pierre ULg; Sindic, Marianne ULg et al

in Viandes et Produits Carnés (2012, November), Hors-Série

The aim of this study is to evaluate the influence of pork production sector on technological behavior of raw material, properties of the ham final product and consumer preferences. An experimental ... [more ▼]

The aim of this study is to evaluate the influence of pork production sector on technological behavior of raw material, properties of the ham final product and consumer preferences. An experimental manufacturing assay of Ardenne Ham has been conducted for this purpose. Results show few incidence of pork production conditions on technological properties and chemical or sensory characteristics of hams. The preference tests, carried out with a sensory panel using several criteria, showed that consumers were able to distinguish two groups of hams, according to their fat content. They have a preference for lower-fat ham from one of the studied sectors. Method of multicriteria decision shows no overall preference for one of the submitted ham. [less ▲]

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See detailCouplage des modèles numériques SWAT et FeFlow pour l'étude des flux de nitrate à l'échelle d'un bassin versant agricole posé sur un aquifère sableux. Calibrage, validation et test de scénarios pour l'évaluation de pratiques agricoles plus durables en terme de gestion de l'azote
Vandenberghe, Christophe ULg; Deneufbourg, Mathieu ULg; Gaule, David et al

in Bulletin du groupe francophone Humidimétrie et Transferts en milieux poreux (2012, November), 58

Quatre prises d’eau exploitées à Arquennes (Belgique) sont contaminées par le nitrate. Leurs bassins d’alimentation sont situés en zone agricole caractérisée par un sol limoneux sur un aquifère sableux ... [more ▼]

Quatre prises d’eau exploitées à Arquennes (Belgique) sont contaminées par le nitrate. Leurs bassins d’alimentation sont situés en zone agricole caractérisée par un sol limoneux sur un aquifère sableux. Depuis 2004, ces bassins servent de site pilote dans le cadre de l’évaluation du Programme de Gestion Durable de l’Azote (PGDA), transposition de la Directive « Nitrates » en droit wallon. Les modèles numériques SWAT et FEFLOW ont permis de simuler les flux d’eau et de nitrate depuis la surface jusqu’aux galeries. Après calibrage et validation des modèles (sur la base d’une caractérisation du sol et du sous-sol et de traçages en milieux saturé et non saturé), plusieurs scénarios de pratiques agricoles ont été simulés afin de prédire l’évolution qualitative des eaux. L’expérience d’Arquennes a démontré que le recours au couplage SWAT / FEFLOW permet de proposer des solutions environnementales réalistes pour atteindre les objectifs fixés par la DCE. [less ▲]

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See detailDoes processing speed protect from age-related decline in cognitive control?
Manard, Marine ULg; Carabin, Delphine; Collette, Fabienne ULg

in Frontiers in Human Neuroscience (2012, October 27)

Age-related difficulties have been reported on proactive control whereas reactive control seems to remain intact (Braver, Gray, & Burgess, 2007; Braver, 2012). This study investigated the potential ... [more ▼]

Age-related difficulties have been reported on proactive control whereas reactive control seems to remain intact (Braver, Gray, & Burgess, 2007; Braver, 2012). This study investigated the potential influence of speed of processing abilities on the age-related decline in proactive control. We used a working memory recognition paradigm involving proactive or reactive cognitive control by manipulating the interference level across items. 80 young adults (18-29 years old) and 80 healthy older adults (60-89 years old) were included. The main results revealed significant effects of age on sensitivity to interference. As expected, reactive control performance remained intact with aging (similar interference effect in the two groups). In contrast, we observed a larger interference effect in the proactive condition in aging. Finally, when the groups are matched according to their processing speed (assessed by the Code task of the WAIS III, with both younger and older adults having a score comprised between 60 and 93), the effect of age on sensitivity to interference disappeared. In other words, when younger and older adults had similar speed of processing abilities, no age-related proactive control decline was observed. In conclusion, beyond the fact that this study confirms the selective age-related decline in proactive control, it also indicates that speed of processing, a measure considered as reflecting the integrity of cognitive functioning during aging (Salthouse, 1996), influences the efficiency of proactive control in that population. [less ▲]

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See detailDetermination of Romanian alfalfa crude protein and crude fiber contents as well as in vitro organic matter digestibility by NIR spectrometry
Dale, Laura ULg; Thewis, André ULg; Rotar, Ioan et al

in Scientific Papers. Series D, Animal Science (2012, October 04)

Alfalfa (Medicago sativa L.) is a high quality forage which has been used worldwide. The superiority of alfalfa lies in its high yield, high protein content and high digestibility. The aim of this study ... [more ▼]

Alfalfa (Medicago sativa L.) is a high quality forage which has been used worldwide. The superiority of alfalfa lies in its high yield, high protein content and high digestibility. The aim of this study was to develop a simple, fast and non-destructive method, named Near Infrared Spectroscopy (NIRS) to determinate alfalfa quality. To realize this study, alfalfa samples were obtained from Mănăştur Experimental Station – Farm Cojocna in 2008–2009, in one experiment carried out using randomization blocks design with two experimental factors (mineral fertilization and period of harvest). Alfalfa quality was first determinated on 48 samples by classical analyses: crude protein CP (AOAC, 1990), crude fiber CF (Fiber Cap, FOSS, DK) and in vitro organic matter digestibility OMDrt (DeBoever, 1986). Then the samples were scanned by NIRS. Calibration models were performed by PerkinElmer Spectrum Quant + 4.21 program (USA) on the 48 samples determinated by classical analysis. The results showed fully confirmed by acceptable coefficients of determination and standard error of cross-validation (R2=0.96 for CP, 0.94 for CF, 0.98 for OMDrt and SECV=0.77 for CP, 1.35 for CF, 1.13 for OMDrt). Successful results for prediction of other 176 alfalfa samples were then obtained using these calibration models: SEP=0.869 for CP, 1.058 for CF, 1.058 for OMDrt). The highest CP and OMDrt values of alfalfa were obtained in bud stage (22.0% and 66.0% respectively). While for CF, the highest content was registered in the seed formation stage (46.0%). The NIRS technique offers us the possibility to determinate rapidly and easily Romanian alfalfa important parameters, but the system could also be used for the determination of other constituents. [less ▲]

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See detailAccompagnement des aidants des patients Alzheimer comme approche non-pharmacologique essentielle!
Adam, Stéphane ULg; Bottard, Aude ULg; Crespin, Maurane ULg et al

in Revue Francophone de Gériatrie et de Gérontologie (2012, October), XIX(188), 326-327

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See detailCumulative Time in Band (cTIB): Glycemic Level, Variability and Patient Outcome All in 1
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

in Intensive Care Medicine (2012, October), 38 (Suppl 1)

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See detailAssociation between chondrocytes hypertrophy and angiogenesis of cartilage in osteoarthritis
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Delcour, Jean-Pierre et al

in Arthritis and Rheumatism (2012, October), 64(10 (Suppl)), 760

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See detailArbitrary Lagrangian Eulerian Modelling of Tension Levelling
Boman, Romain ULg; Parrico, Anthony; Legrand, Nicolas et al

in Matériaux et Techniques (2012, October), 100(Hors série 2012), 40-42

This paper presents a two-dimensional model of tension levelling using the Arbitrary Lagrangian Eulerian (ALE) approach. During the simulation, the ALE mesh remains globally fixed along the rolling ... [more ▼]

This paper presents a two-dimensional model of tension levelling using the Arbitrary Lagrangian Eulerian (ALE) approach. During the simulation, the ALE mesh remains globally fixed along the rolling direction. Therefore, the required number of finite elements is much smaller than in the Lagrangian case and smaller CPU times are obtained for the same accuracy on the results. The ALE model is first validated against a classical equivalent Lagrangian model. Then, both sets of numerical results are compared to experimental measurements from the pilot mill of ArcelorMittal Maizières R&D. [less ▲]

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See detailPulsational Mode Identification Based on Chromatic Amplitude Behaviour: Recent Results for Rapidly Oscillating Subdwarf B Stars
Randall, S.K.; Fontaine, G.; Brassard, P. et al

in Astronomical Society of the Pacific Conference Series (2012, October), 462

We present recent results from mode identification based on the amplitude-wavelength behaviour for three rapidly pulsating subdwarf B stars: HS 2201+2610, EC 11583–2708 and EC 20338–1925.

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See detailChemometric tools for NIRS and NIR hyperspectral imaging
Dale, Laura ULg; Thewis, André ULg; Rotar, Ioan et al

in Bulletin of USAVM Cluj Napoca, Agriculture (2012, September 27), 69(1), 70-76

Nowadays in agriculture, new analytical tools based on spectroscopic technologies are developed. Near Infrared Spectroscopy (NIRS) is a well known technology in the agricultural sector allowing the ... [more ▼]

Nowadays in agriculture, new analytical tools based on spectroscopic technologies are developed. Near Infrared Spectroscopy (NIRS) is a well known technology in the agricultural sector allowing the acquisition of chemical information from the samples with a large number of advantages, such as: easy to use tool, fast and simultaneous analysis of several components, non-polluting, non-invasive and non destructive technology, and possibility of online or field implementation. Recently, NIRS system was combined with imaging technologies creating the Near Infrared Hyperspectral Imaging system (NIR-HSI). This technology provides simultaneously spectral and spatial information from an object. The main differences between NIR-HSI and NIRS is that many spectra can be recorded simultaneously from a large area of an object with the former while with NIRS only one spectrum was recorded for analysis on a small area. In this work, both technologies are presented with special focus on the main spectrum and images analysis methods. Several qualitative and quantitative applications of NIRS and NIR-HSI in agricultural products are listed. Developments of NIRS and NIR-HSI will enhance progress in the field of agriculture by providing high quality and safe agricultural products, better plant and grain selection techniques or compound feed industry’s productivity among others. [less ▲]

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See detailSacralisation et légitimation. Les hors-textes de la revue "L'Éprouvette" : fragments d’une Histoire discriminante
Dejasse, Erwin ULg

in Comicalités : Études de Culture Graphique (2012, September 27)

Between 2006 and 2007, L’Association have published the three issues of L’Éprouvette. These are, among other, illustrated by thirty-four images that are hugely enlarged fragments of comic’s panels. By ... [more ▼]

Between 2006 and 2007, L’Association have published the three issues of L’Éprouvette. These are, among other, illustrated by thirty-four images that are hugely enlarged fragments of comic’s panels. By comparing this with similar realizations (the exhibition Bande dessinée et Figuration narrative, the column « Cases mémorables » of the journal Les Cahiers de la bande dessinée), this paper asks about what it means reproducing comics’ fragments. It also tries to analyze the role played by these images within the journal and the links with the rest of the content. Endlessly, still by putting it in prospect with the realizations here above mentioned, it tries to see in what extent these images reflect a certain view about the history of the comic. [less ▲]

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See detailImpact of extracorporeal shock wave therapy in the treatment of chronic lateral epicondylitis
Deroanne, Adrien; Deroanne, Didier; Florkin, Marc et al

in Regional Anesthesia & Pain Medicine (2012, September), 37(5 - Suppl 1), 263

Background and aim: radial shock wave therapy (RSWT) is a relatively new way to treat chronic tendinopathies, such as lateral epicondylitis. However, very few studies have been realized on this subject ... [more ▼]

Background and aim: radial shock wave therapy (RSWT) is a relatively new way to treat chronic tendinopathies, such as lateral epicondylitis. However, very few studies have been realized on this subject, and the results are very divergent. We aimed to observe the impact of this technique on chronic lateral elbow pain. Method: fifteen subjects who had a lateral epicondylitis for at least 3 months were included in the study. Two groups were formed: experimental (10 subjects) who received 6 sessions of physiotherapy and RSWT, and the control group (5 subjects) who received exclusively physiotherapy. Physiotherapy sessions were composed of massage, stretching, diacutaneous fibrolysis, and a muscular eccentric program of the wrist extensor muscles. We evaluated the subjects before the first session, and after 6 weeks of treatment with a pain visual analog scale (VAS), the painless wrist flexion amplitude, ant the “Patient-Rated Tennis Elbow Evaluation” (PRTEE) questionnaire. Results: the difference between initial and final evaluations was significant (regarding to the wilcoxon test) for all of the parameters studied (p=0,028 for the VAS, p=0,005 for the wrist flexion amplitude, and p=0,005 for the PRTEE) in the experimental group. It wasn’t significant in the control group (VAS p=0,144128, wrist flexion amplitude p=0,079617, and PRTEE p=0,067890). The comparison between the two groups was not significant, neither in the beginning, nor in the end of the treatment (regarding to the Umann and Whitney test) Conclusions: RSWT associated to physiotherapy is a more effective treatment for lateral epicondylitis than physiotherapy alone. [less ▲]

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See detailErythropoiesis in acromegaly : effect of GH or IGF-1 ? Data from the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 45

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See detailPlatelet-rich plasma (PRP) to treat patellar tendinopathy: preliminary results
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; SIMONI, Paolo ULg et al

in Regional Anesthesia & Pain Medicine (2012, September), 37(5 - Suppl 1), 216

Introduction: Patellar tendinopathy, often remain rebel to conservative treatments. Researches have specifically demonstrated the platelets action as mediator and/or enhancer of tissue healing. The aim of ... [more ▼]

Introduction: Patellar tendinopathy, often remain rebel to conservative treatments. Researches have specifically demonstrated the platelets action as mediator and/or enhancer of tissue healing. The aim of our study was to investigate the effect of 1 injection of PRP in patients suffering from chronic patellar tendinopathy. Methods: Patients performed imaging (US and MRI) and functional assessments, and a clinical examination using an algometer, before treatment and 6 weeks after PRP treatment. They were also invited to answer to questionnaire relative to pain and functional status. PRP was obtained from autologous blood using an apheresis system (COM.TEC, Fresenius). The injection of 6mL of PRP was realised without local anaesthesia into the proximal insertion of the patellar tendon. A 48h rest-time was recommended after infiltration. Afterwards, a submaximal eccentric reeducation was initiated 1 week after infiltration 3 times a week during 5 weeks. In case of pain, anti-inflammatory drugs were prohibited and patient were encouraged to take class I or II painkillers. Results: At this time, 10 patients with patellar tendinopathy were included in our study. Pre-injection tests revealed pain of the upper part of the patellar tendon just below the patella, associated with loss of function. Imaging exams confirmed diagnosis. Six weeks post-injection, the clinical status was improved in all patients, with a significant decrease of algo-functional scores. The pain reported during functional assessments was decreased (in particular for the eccentric actions), yet no significant improvement of physical performances was observed. We found no significant differences between imaging exams before and 6 weeks after PRP injection. Conclusion: One in situ injection of PRP clinically improved patients with patellar tendinopathy 6 weeks after treatment. All the 10 patients reported a decrease of pain during day-life and through physical activities. However nor functional performances neither imaging were improved. [less ▲]

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See detailComparison of temperature estimates from heat transport model and electrical resistivity tomography during a shallow heat injection and storage experiment
Hermans, Thomas ULg; Daoudi, Moubarak ULg; Vandenbohede, Alexander et al

in Berichte der Geologischen Bundesanstalt (2012, September), 93

Groundwater resources are increasingly used around the world as geothermal systems. Understanding physical processes and quantification of parameters determining heat transport in porous media is ... [more ▼]

Groundwater resources are increasingly used around the world as geothermal systems. Understanding physical processes and quantification of parameters determining heat transport in porous media is therefore important. Geophysical methods may be useful in order to yield additional information with greater coverage than conventional wells. We report a heat transport study during a shallow heat injection and storage field test. Heated water (about 50°C) was injected for 6 days at the rate of 80 l/h in a 10.5°C aquifer. Since bulk electric resistivity variations can bring important information on temperature changes in aquifers (water electric conductivity increases about 2%/°C around 25°C), we monitored the test with surface electric resistivity tomography and demonstrate its ability to monitor spatially temperature variations. Time-lapse electric images clearly show the decrease and then the increase in bulk electric resistivity of the plume of heated water, during respectively the injection and the storage phase. This information enabled to calibrate the conceptual flow and heat model used to simulate the test. Inverted resistivity values are validated with borehole electromagnetic measurements (EM39) and are in agreement with the temperature logs used to calibrate the parameters of the thermo-hydrogeological model for the injection phase. This field work demonstrates that surface electric resistivity tomography can monitor heat and storage experiments in shallow aquifers. These results could potentially lead to a number of practical applications, such as the monitoring or the design of shallow geothermal systems or the use of heated water to replace salt water in tracer tests. [less ▲]

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See detailCurrent evidence and indications for Prolotherapy with Platelet Rich Plasma in chronic musculoskeletal conditions
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

in Regional Anesthesia & Pain Medicine (2012, September), 37(5 - Suppl 1), 104-106

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See detailAge, GH and tumor size : the triangular relation in acromegaly. Data from the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 43

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See detailAires et agrandissements. Maths & Manips pour la transition primaire-secondaire
Guissard, Marie-France; Henry, Valérie ULg; Lambrecht, Pauline et al

in Losanges (2012, September), 18

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See detailAging of the newly diagnosed acromegalic patients : data frome the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 33

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See detailAnodal transcranial direct current stimulation over the visual cortex as a preventive treatment of migraine: a proof-of-concept study.
Sasso d'Elia, Tullia; Vigano, Alessandro; SAVA, Simona Liliana ULg et al

in Frontiers in Human Neuroscience (2012, September)

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See detailBevacizumab for recurrent glioblastoma, early observations on patient outcome in the belgian medical need program
Duerinck, Johnny; Clement, Paul; Bouttens, F et al

in Neuro-Oncology (2012, September), 14(3), 51

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See detailChange in naming abilities between the ages of 50 and 90: The importance of analyzing naming latency
Verhaegen, Clémence ULg; Poncelet, Martine ULg

in Stem-, spraak- en taalpathologie (2012, September), 17(2), 126-128

This study tests the controversial hypothesis that word naming difficulties may arise in individuals as young as their 50s. Participants of 25-35, 50-59, 60-69 and above 70 years of age were given a ... [more ▼]

This study tests the controversial hypothesis that word naming difficulties may arise in individuals as young as their 50s. Participants of 25-35, 50-59, 60-69 and above 70 years of age were given a picture naming task. To uncover subtle naming difficulties, correct naming latencies were analyzed, in addition to accuracy. Moreover, in order to control whether the expected slower naming latencies could be due to a general slowing affecting all cognitive tasks, participants were also given an odd/even judgment task to assess cognitive processing speed. In participants in their 50s, we found subtle naming difficulties revealed by longer naming latencies, unaccompanied by any decrease in naming accuracy. The age-related naming disadvantage increased with age with the onset of naming errors. Thus, in adults in their 60s and their 70s, the results showed both a decrease in accuracy and an increase in correct naming latencies. Moreover, the increase in naming latencies remained significant even after controlling for odd/even judgment latencies, suggesting a degradation specific to the picture naming task. We assumed that these slower latencies may result from a language-specific impairment. [less ▲]

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See detailPulsational Mode Identification Based on Chromatic Amplitude Behaviour: Recent Results for Rapidly Oscillating Subdwarf B Stars
Randall, Suzanna K; Fontaine, Gilles; Brassard, Pierre et al

in Astronomical Society of the Pacific Conference Series (2012, September), 462(232),

We present recent results from mode identification based on the amplitude-wavelength behaviour for three rapidly pulsating subdwarf B stars: HS 2201+2610, EC 11583-2708 and EC 20338-1925.

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See detailGH or IGF-1 : which one is raising blood glucose ? Hints from the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal of Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3),

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See detailA salt tracer test monitored with surface ERT to detect preferential flow and transport paths in fractured/karstified limestones
Robert, Tanguy ULg; Caterina, David ULg; Deceuster, John et al

in Berichte der Geologischen Bundesanstalt (2012, September), 93

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See detailThe Physics of Pulsating White Dwarf Stars
Fontaine, G.; Brassard, P.; Charpinet, S. et al

in Astronomical Society of the Pacific Conference Series (2012, September), 462

We present a summary of the properties of white dwarf stars, beginning with a brief reminder of their basic characteristics. We continue with a discussion of the spectral types, evolution, and other ... [more ▼]

We present a summary of the properties of white dwarf stars, beginning with a brief reminder of their basic characteristics. We continue with a discussion of the spectral types, evolution, and other properties of cooling white dwarfs, with an emphasis on the internal physics. We then introduce the pulsating white dwarfs and provide an updated view of their status. We finally discuss the impact (real and potential) of asteroseismology on our knowledge of degenerate stars. [less ▲]

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See detailIn vivo antimalarial activity of twigs extracts from Keetia leucantha
Béro, Joanne; Frederich, Michel ULg; Quetin-Leclercq, Joëlle

in Planta Medica (2012, August), 78(11), 1188

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See detailAnalytical criteria for use of MS/MS for determination of dioxins and dioxin-like PCBs in feed and food
Kotz, A; Malisch, R; Focant, Jean-François ULg et al

in Organohalogen Compounds (2012, August), 74

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See detailPotential anticancer activity of young Carpinus betulus leaves
Cieckiewicz, Ewa ULg; Angenot, Luc ULg; Gras, T et al

in Planta Medica (2012, August), 78(11), 1178

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See detailEffect of artificial insemination site on post-mating endometritis in mares
Rodier, Clémentine; Ponthier, Jérôme ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (2012, August), 47(suppl 5), 103

Aim of the study was to determine the effect of artificial insemination (AI) location on post-mating endometrial inflammation 1 and 6 days after AI. Six mares with ages ranging from 12 to 23 years were ... [more ▼]

Aim of the study was to determine the effect of artificial insemination (AI) location on post-mating endometrial inflammation 1 and 6 days after AI. Six mares with ages ranging from 12 to 23 years were inseminated with a same batch of frozen semen for 3 consecutive cycles. Mares were inseminated with the following procedures in a random order: (1) Deep uterine insemination with 4ml of semen; (2) Horn bifurcation with 4ml of semen; (3) Horn bifurcation with 4ml of semen and 6ml of extender. During each cycle, Cotton (C) and Brush (B) swabs were collected at 4 different moments: mid- dioestrus, mares with a 35mm follicle, 24h and 6 days after AI. Swabs were smeared on slides, fixed and stained (Diff-Quick®) before examination under light microscopy. Proportions of inflammatory and epithelial cells were determined and differences were studied with kruskal-wallis test for non-parametric data. Distensions of uterine lumen due to intraluminal fluid observed during ultrasound exams were measured and recorded. Quality of slides was better (p=0.0006) with B swabs than C swabs with 97% versus 65% of slides readable. B swabs were associated with higher percent of endometrial cells retrieved (p=0.0323), making them a better tool for endometritis diagnosis, which is consistent with our previous reports. Volume of intraluminal fluid and percent of inflammatory cells, both on B and C swabs, were not influenced by AI location regardless the timing of sampling. Small volume deep uterine AI did not significantly affect inflammatory response by the endometrium in our experiment. [less ▲]

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See detailMeasurement of human levels of Dechlorane 602 by CZC-NCI-HRTOFMS
Brasseur, Catherine ULg; PIRARD, Catherine ULg; L'Homme, Benjamin ULg et al

in Organohalogen Compounds (2012, August), 74

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See detailSquamous metaplasia of the prostate and diffuse alopecia in a 13-year-old castrated dog due to chronic ingestion of exogenous estradiol
Van Den Berghe, Femke ULg; Ponthier, Jérôme ULg; Deleuze, Stefan ULg

in Reproduction in Domestic Animals (2012, August), 47(S4), 561

Introduction. A 13-year old whippet with a generalized progressive alopecia since 2 years was referred to our clinic to perform a low-dose dexamethasone stimulation test and abdominal ultrasound to ... [more ▼]

Introduction. A 13-year old whippet with a generalized progressive alopecia since 2 years was referred to our clinic to perform a low-dose dexamethasone stimulation test and abdominal ultrasound to exclude or confirm Cushing disease. The dog had previously been treated with trilostane for 4 months without having any positive effects. Earlier blood analysis showed no significantly abnormalities and ACTH stimulation test was negative. Having bilateral cryptorchidism, the dog was castrated at young age. Clinical findings and treatment. Abdominal ultrasound revealed a slightly enlarged right adrenal gland (diameter of 1 cm at the cranial part). The prostate was enlarged and heterogeneous with multiple anechogenic cavities, indicating hormonal stimulation. Craniad the prostate and ventrally of the bladder, a hypoechogenic, oval structure (3 cm by 1.7 cm) could be seen, and was suspected to be a remaining cryptorchide testicle. Fine needle aspiration however showed that the structure contained a thick purulent liquid, with large amounts of polymorhonuclear white blood cells. Blood analysis revealed a leukocytosis (29370/mm3) with neutrophilia (23202/mm3). Low-dose dexamethasone test definitely excluded Cushing disease (basal cortisol levels 2,17 µg/dl; cortisol at 4 and 8 hours < 1 µg/dl). A prostatic wash was performed and revealed a severe prostatitis and presence of keratinized prostatic cells, indicating a squamous metaplasia of the prostate. Measurement of seric LH levels (LH Witness®, Synbiotics) showed an LH concentration lower than 1 ng/ml, indicating a hormonal negative feedback on the hypothalamo-hypophyso-gonadal axis. After a more thorough anamnesis, it became clear that the dog was licking and ingesting a transdermal estradiol containing cream (Estrogel®) from his owner, since two years, causing his symptoms. The dog was put on antibiotic treatment for the prostatitis (enrofloxacine 10 mg/kg SID) and underwent surgery to excise the abscess cranial of the prostate. The two ductuli deferentes were attached to this structure. Histopathological analysis revealed this tissue to be embryological remanents or a morphological anomaly with a urogenital origin. Control after 4 weeks showed that the prostate slightly decreased in volume, however, anechogenic cavities where still present of which one increased in volume. The alopecia was still present as well, both probably due to a prolonged action of the estrogens. Conclusion. Even though injectable estrogen preparations are not longer available in veterinary medicine in Europe, a thorough anamnesis towards other exogenous estrogen sources is still necessary and can reduce the number of supplementary exams performed. [less ▲]

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See detailEnvironmental enrichment can accentuate condtioned reward induced by representative cocaine doses in mice
Geuzaine, Annabelle ULg; Tirelli, Ezio ULg

in Journal of Psychopharmacology (2012, August), 26(8), 70

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See detailMyeloperoxidase as an indicator of endometritis in the mare: preliminary results
Parrilla Hernandez, Sonia ULg; Franck, Thierry ULg; Ponthier, Jérôme ULg et al

in Reproduction in Domestic Animals (2012, August), 47(suppl 5), 65

Diagnosis of endometritis in the mare is routinely based on the presence of polymorphonuclear cells (PMNs) on endometrial smears. Studies show a relation between PMNs and myeloperoxidase (MPO), an enzyme ... [more ▼]

Diagnosis of endometritis in the mare is routinely based on the presence of polymorphonuclear cells (PMNs) on endometrial smears. Studies show a relation between PMNs and myeloperoxidase (MPO), an enzyme released by PMNs during degranulation or after cell lysis, in many fluids and tissues. The aims of this study were to assess the presence and concentration of MPO in the mare’s uterus, and to investigate its relation with PMNs. Thirty-six cycles from 28 mares (ages ranging from 6 to 22 years) were used. Endometrial cytological samples were obtained with a small volume uterine flush and either a uterine cotton swab or a cytobrush, when a follicle >35 mm was observed by ultrasound. The smears were stained with Diff-QuickÒ and one or more PMNs per field (400·) was diagnosed as endometritis. The supernatant of the flushes was used to measure MPO concentration with a specific equine MPO ELISA assay. Our results showed the presence of MPO in the equine uterus during oestrus (mean = 2839 + 2785). MPO concentrations were signifi- cantly (p < 0.05) higher in samples with positive cytological results. Occasionally, some samples with negative cytological results showed high MPO concentration, but the opposite was never observed. Clinical signs of endometritis are not always present, or they may be delayed. An early diagnostic improves the success of treatment. Our results show that high quantities of MPO in endometrial samples indicate the presence of PMNs. Further studies are needed to determine if MPO concentration could be routinely used as a tool of early detection of endometritis. [less ▲]

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See detailThe effect of homologous prostatic fluid on the parameters of dog semen extended and frozen in Tris-egg yolk and INRA Freeze: preliminary results
Stanescu, Pascal; Van Den Berghe, Femke ULg; Aissi, Adel et al

in Reproduction in Domestic Animals (2012, August), 47(s4), 431

Recent studies showed that the cryoprotector component of egg yolk for the freezing of canine semen is represented by the low density lipoproteins (LDL), while the others components of egg yolk have a ... [more ▼]

Recent studies showed that the cryoprotector component of egg yolk for the freezing of canine semen is represented by the low density lipoproteins (LDL), while the others components of egg yolk have a number of detrimental effects on the frozen-thawed canine semen. The aim of this study was to compare the effect of a LDL commercial extender used for stallion semen – INRA FreezeÒ (IMV Technologies, L¢Aigle, France) with a standard extender for dog semen containing Tris, fructose, glycerol and 20% egg yolk (TFG-EY). Since there are some conflicting reports concerning the effect of prostatic fluid on sperm function, we also investigated if the effect of post-thaw dilution with autologous prostatic fluid on viability, motility and acrosome status of frozen-thawed canine spermatozoa is correlated with the composition of the extender. Semen was collected from six Beagle dogs and each sperm rich fraction was divided in two parts: one was diluted with INRA FreezeÒ and the other with TFG-EY and frozen with the same protocol. The third fraction of each ejaculate was collected separately, centrifuged at 1118 · g for 10 min and the supernatant was frozen at )18°C until use. For each extender, two straws were thawed: one straw was diluted 1:2 with autologous prostatic fluid, while the other was not diluted at all. Motility (CASA, IVOS; Hamilton Thorne, USA), viability and acrosome status (Guava EasyCyteÒ flow cytom- eter; IMV Technologies, L¢Aigle, France), morphology (Diff-Quick stain) were assessed at 5 min, 1 h and 2 h post-thaw (T0, T1, T2). Statistical analyses were performed with IBM SPSS software (ver. 19 for Windows; IBM, New York, NY, USA). The results are presented as mean values and a p value <0.05 was considered statistically significant. Viability, total and progressive motility and the percentage Ó 2012 Blackwell Verlag GmbH 432 Abstracts of intact acrosomes were higher (p < 0.05) for the TFG-EY group with or without the addition of the prostatic fluid. The results for motility in the INRA Freeze group were dramatically low compared to the TFG-EY group. There were no significant differences regarding the morphology of fresh and frozen semen for any of the four groups. Addition of prostatic fluid for the TFG-EY group significantly reduced the total and progressive motility at T0, T1 and T2 (p < 0.05), but showed no influence for the INRA Freeze group. This data show that the effect of prostatic fluid regarding motility differs between the two extenders. This may illustrate either an inhibitory effect of some components of the INRA FreezeÒ on the noxious effects of the prostatic fluid or conversely an enhancing effect of the TFG-EY on those. Alternatively, it could be that low values obtained with INRA FreezeÒ did not permit highlighting the effects of prostatic fluid. [less ▲]

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See detailA flow cytometric study on the effect of myeloperoxidase on stallion spermatozoal motility and structure
Ponthier, Jérôme ULg; Parrilla Hernandez, Sonia ULg; Van Den Berghe, Femke ULg et al

in Journal of Equine Veterinary Science (2012, August), 32(8), 509

Myeloperoxidase (MPO) is a pro-oxidant enzyme that is normally contained in neutrophils. MPO has recently been associated with keratinized cells and with decreased post-thaw motility in stallion semen [1 ... [more ▼]

Myeloperoxidase (MPO) is a pro-oxidant enzyme that is normally contained in neutrophils. MPO has recently been associated with keratinized cells and with decreased post-thaw motility in stallion semen [1]. The aim of the study was to determine effects of experimental addition of active MPO on motility, mitochondrial potential, apoptosis induction, membrane and acrosome integrity in equine semen. Three stallions were used and semen was collected four times. Extended (INRA96TM) semen was processed for density gradient centrifugation (Equipure Bottom Layer®) [2]. Purified pellet was re-extended to 100x106spermatozoa/ml in INRA96TM and divided in 3 samples. One sample was used for control and active human MPO (Calbiochem, Merck) was added in the other two samples to final concentration of 5 or 50 ng/ml. After incubation (2 hours, 20°C), motility was analysed with Computer Assisted Semen Analysis (IVOS, Hamilton-Throne, Beverly, MA, USA) and cytometric analyzes were perfomed with EasyCyte (IMV). Mitochondrial potential and apoptosis were assayed using Guava Mitopotential JC-1 and 7-AAD kit (Millipore). Membrane and acrosome integrity were respectively assayed with PI (Propidium Iodide) (Invitrogen) and PNA (Peanut Agglutinin-Fluorescein Iso Thio Cyanate) (Sigma-Aldrich). Statistical differences (p<0.05) were determined using Kruskall-Wallis test. No effect of the stallions was observed on parameters assayed in this study. Unlike total motility, progressive motility was decreased in both MPO concentrations (p<0.001). MPO addition had no effect on membrane and acrosome integrity. No differences were detected for the percentages of spermatozoa having polarised or depolarised mitochondria. Apoptosis, assayed by 7-AAD fluorescence, was not increased by the treatments. Our results agree with previously published effects of in vitro ROS production systems with xanthine oxidase [3], showing an effect on motility but no influence on mitochondria and membrane or acrosome integrity. However, membrane lipoperoxidation was increased by ROS in this study [3], and it could be linked to the impaired motility also observed in our protocol. Further studies with increasing concentrations of added MPO should be conducted to correlate motility with lipoperoxidation. References [1] Ponthier J, Desvals M, Franck T, de la Rebiere de Pouyade G, Spalart M, Palmer E, Serteyn D, Deleuze S. Myeloperoxidase in equine semen: Concentration and Localization during freezing processing. Journal of Equine Veterinary Science 2012;32: 32-37. [2] Edmond AJ, Teague SR, Brinsko SP, Comerford KL, Waite JA, Mancill SS, Love CC, Varner DD. Effect of density-gradient centrifugation on quality and recovery rate of equine spermatozoa. Animal Reproduction Science 2008;107: 318-318. [3] Baumber J, Ball BA, Gravance CG, Medina V, Davies-Morel MC. The effect of reactive oxygen species on equine sperm motility, viability, acrosomal integrity, mitochondrial membrane potential, and membrane lipid peroxidation. J Androl 2000;21: 895-902. [less ▲]

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