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See detailComparison of the Heart-type fatty acid-binding protein (H-FABP) with the high sensitive cardiac troponin T in healthy runners
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; BREVERS, Eric ULg et al

in Biochimica Clinica (2013, May), 37(SS), 544

Background: Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. It is an early marker ... [more ▼]

Background: Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. It is an early marker for acute coronary syndrome. Troponin T (TnT) is a component of the contractile apparatus of the striated musculature. Cardiac TnT is a cardio-specific, highly sensitive marker for myocardial damage. The aim of our study was to compare the results obtained with the H-FABP and the highly sensitive cardiac troponins (hsTnT) and to test their cardiospecificity in healthy runners. Methods: Twenty three runners (marathon) were enrolled. We drowned samples at three times: just before (T0), just after (T1), and three hours after the end of the race (T3). H-FABP was determined with a Randox immunoturbidimetric assay and hs-TnT with a Roche electrochemiluminescence immunoassay, both on Cobas 6000. A linear regression was calculated to observe if there is any correlation between the two biomarkers. Values above the 95th percentile for H-FABP (2.5ng/mL) and the 99th percentile for hsTnT (14ng/L) were considered as positive. Results: At T0, none of the subjects were positive for hsTnT but 35% were positive for H-FABP; at T1, 83% for hsTnT and 100% for H-FABP; at T3, 83% for hsTnT and 96% for H-FABP. At T0, the regression equation was H-FABP T0 = 3.9454 – 0.1001 x hsTnT T0; at T1: H-FABP T1 = 51.838 – 1.7026 x hsTnT T1; at T3: H-FABP T3 = 47.977 – 1.6193 x hsTnT T3. No correlation was observed between the two biomarkers at the different time. Conclusions: We observed a significant increase of H-FABP and hsTnT in runners. These markers are independent to each other. These values could biologically correspond to a heart ischemia. However, we suggested that exercise-induced cardiac hsTnT and H-FABP release is not a marker of exercise-induced pathology but likely a physiologic response to effort or an exercise-induced cardiac remodelling. [less ▲]

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See detailEvaluation of the performance of the new automated IDS-ISYS 1,25-dihydroxy vitamin D assay
GADISSEUR, Romy ULg; LUKAS, Pierre ULg; CARLISI, Ignazia ULg et al

in Biochimica Clinica (2013, May), 37(SS), 498

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See detailTherapeutic Strategy and Patient Outcome during the First 2 Years of Pediatric Crohn’s Disease
Veereman, G; Mahachie John, Jestinah ULg; De Greef, E et al

in Journal of Pediatric Gastroenterology and Nutrition (2013, May)

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See detailIs ultra-short cold ischemia the key to ischemic cholangiopathy avoidance in DCD-LT?
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Cheham, S et al

in Acta Chirurgica Belgica (2013, May), Supplement 113(3), 6729

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See detailEvaluation of the third-generation to second-generation PTH ratio on the Liaison XL (DIASORIN) as a marker for parathyroïd carcinoma
Schleck, Marie-Louise; LAURENT, Terry ULg; GADISSEUR, Romy ULg et al

in Biochimica Clinica (2013, May), 37(SS), 161

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See detailHeavy/light chain (HLC) and free light chain (FLC) analysis allow sensitive monitoring of multiple myeloma patients and AID detection of clonal changes
Dierge, Laurine; LUTTERI, Laurence ULg; Chauvet, D et al

in Biochimica Clinica (2013, May), 37(SS), 618

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See detailImpact of strenuous exercise on the release of cardiac biomarkers
LE GOFF, Caroline ULg; MELON, Pierre ULg; Kaux, Jean-François ULg et al

in Biochimica Clinica (2013, May), 37(SS), 545

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured ... [more ▼]

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured by new commercially available high-sensitive methods in subjects un-dergoing the Maasmarathon. Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Methods: Twenty eight subjects (26 ♂, 42.5±11yo) underwent a race of 42.195 kilometers be-tween Visé (Belgium) and Maastricht (The Netherlands). We drowned blood sample before (T0), just after (T1) and three hours after the race (T3). In all patients, cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. The protocol was approved by the ethics committee of the University of Liège (Belgium). All subjects gave their informed consent. All statistical analyses were performed using Medcalc version 8.1 for Windows. p-value <0.01 was regarded as statistically significant. Results: There was a significant difference between hsTnT concentrations at T0 and T1 (p<0.0001), and between T0 and T3 (p<0.001) for NT-proBNP, but not between T1 and T3. This observation appeared only after a strenuous exercise but today this type of exercise is not reproduce easier in a laboratory of sport. Moreover, at this moment, nobody knows if these observations would have cardiac consequences at long terms. Conclusions: Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death. [less ▲]

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See detailBiophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline ULg; Nasir, Mehmet Nail ULg; Nott, Katherine ULg et al

in World Academy of Science, Engineering and Technology (2013, May), 77

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic ... [more ▼]

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed. [less ▲]

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See detailBiophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline ULg; Nasir, Mehmet Nail ULg; Nott, Katherine ULg et al

in World Academy of Science, Engineering and Technology (2013, May), 77

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic ... [more ▼]

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed. [less ▲]

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See detailEconomie et formation des Humanités: quelle politique?
Janvier, Antoine ULg

in Dissensus (2013, May), 5

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See detailDetermination of urinary metanephrine, normetanephrine and methoxymetanephrine by liquid chromatography-electrospray tandem mass spectrometry.
LE GOFF, Caroline ULg; PEETERS, Stéphanie ULg; NETCHACOVITCH, Matthieu ULg et al

in Biochimica Clinica (2013, May), 37(SS), 316

Background: The aim of this work was to develop and validate a method for the determination of metanephrine (M), normetanephrine (NM) and methoxymetanephrine (METHO) in urine by liquid chromatography ... [more ▼]

Background: The aim of this work was to develop and validate a method for the determination of metanephrine (M), normetanephrine (NM) and methoxymetanephrine (METHO) in urine by liquid chromatography-tandem mass spectrometry (LCMS-MS) on the Triple Quad TQ 5500 from AB SCIEX. In fact, the determination of M and NM concentrations is used in clinical diagnosis of pheochromocytoma, a rare but potentially fatal tumor arising primarily from the chromaffin cells of the adrenal medulla. Methods: The samples were made of 24 hours acidified urines after centrifugation. Sample preparation was performed by hydrolysing and purifying by extraction column. After that, labeled M, NM and METHO were added as internal standard. Samples were analysed by liquid chromatography-electrospray tandem mass spectrometry. We determined the repeatability, reproducibility, accuracy profile and recovery on pooling urines samples from 9 volunteers analysed in triple run. Results: The results of the precision evaluation are shown in table. The repeatability did not exceed 8.4 % for M, 6.8% for NM and 10.8% for METHO. The concentration range was 71-781 µg/24h, 71-853 µg/24h and 20-854µg/24h for the M, NM and METHO respectively. The total precision did not exceed 12.5%, 11.8% and 8.8% for M, NM and METHO. The limit of quantification (LOQ) were 33.77µg/24h, 14.49µg/24H and 19.81 µg/24H for M, NM and METHO respectively. The accuracy varied from 99.69 to 100.2% for a range of 71 to 781 µg/24h, from 93.32 to 100.2% for a range of 71-853 µg/24h and from 99.85 to 100.6% for the range 20-854µg/24h for M, NM and METHO respectively. The recovery were 99.96% (95% CI for the mean: 96.5-103.4), 99.75% (96.5-102.9) and 100.08 (95.97-104.2) for the M, NM and METHO respectively. Conclusions: We have successfully developed and validated an LCMS-MS method to determine urinary M, NM and METHO on the TQ 5500 from AB SCIEX. It represents a convincing alternative to the HPLC method for a faster and reliable measurement of urinary M, NM and METHO. [less ▲]

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See detailRace Cycling: biological evolution
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; MELON, Pierre ULg et al

in Biochimica Clinica (2013, May), 37(SS), 544

Background: The metabolic and cardiac impact of a cycling effort on blood biology is not very well described in the literature. We aimed to measure the concentration of different biomarkers (cardiac and ... [more ▼]

Background: The metabolic and cardiac impact of a cycling effort on blood biology is not very well described in the literature. We aimed to measure the concentration of different biomarkers (cardiac and metabolic) released during an international cycling race. Methods: Venous blood samples of 15 young men (25.1 ± 6.4 y.o.) were collected just before (T1), just after (T2), 3 hours (T3) after an international cycling race of 179.6 kilometers in Belgium for the determination of cardiac and metabolic biomarkers: red blood cell (RBC), haemoglobin (HgB), creatinin (Cr), highly sensitive troponin T (hsTnT), myoglobin (MYO) and NT-proBNP. All automated assays were performed according to the manufacter’s specifications. For the statistical analysis, an Anova calculated with the Statistica Software version 9.1 was used. Results: RBC and HgB levels varied significantly between T0 and T3 (respectively p=0.0026, and p=0.002). Cr concentration also varied significantly between all times (T0-T1:p<0.0001, T1-T3:p=0.0326 and T0-T3 p=0.0001). These changes might be related to renal flow depletion during exercice. MYO increased significantly between T0 and T1 (p<0.0001), but quickly decreased between T1 and T3, however the T3 level stay higher than T0 (p=0.014). The stress delivered from the physical activity performed during the race induced a significant variation of hsTnT which increased significantly between T0 and T1 (p<0.0001) and stayed higher 3 hours after the end of the exercise (T0-T3: p<0.0001) .The intense exercise delivery by the race induced a significant variation of NT-proBNP, that followed the same kinetic of hsTnT but in smaller proportion. We noticed variations statistically significant between T0 and T1 and between T0 and T3 for NT-proBNP. These increases of cardiac biomarkers were significant but reasonable and could not allow us to talk about cellular necrosis or irreversible injury. Conclusion: Our results show that stress generated by a cycling race could be the cause for the different metabolic variations observed. Troponin T stays without a doubt the most specific marker for stress related to myocardial tissue. Its increase can then be considered as being of interest. [less ▲]

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See detailMDRD VERSUS CKD-EPI EQUATIONS TO ESTIMATE GLOMERULAR FILTRATION RATE IN OBESE PATIENTS
BOUQUEGNEAU, Antoine ULg; CAVALIER, Etienne ULg; Krzesinski, Jean-Marie ULg et al

in Nephrology Dialysis Transplantation (2013, April 18), 28(supplément 1), 117-139

Introduction and Aims: Obesity is recognized as a risk factor both for the development and progression of chronic kidney disease (CKD). Estimating glomerular filtration rate (GFR) is thus especially ... [more ▼]

Introduction and Aims: Obesity is recognized as a risk factor both for the development and progression of chronic kidney disease (CKD). Estimating glomerular filtration rate (GFR) is thus especially important to follow these patients. We have tested the performances of two creatinine-based equations, namely the MDRD and CKD-EPI equations, in an obese population. Conclusions :Both in the global and subgroup analyses, the CKD-EPI equation did not outperform the MDRD study equation. The performances of both equations were worse in CKD patients. These two conclusions were still valid if indexed GFR was considered. [less ▲]

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See detailImmune Reconstitution After Alternative Hematopoietic Stem Cell Transplantation: Comparison of Unrelated Cord Blood and Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation
Servais, Sophie ULg; Lenglinne, Etienne; Porcher, Raphael et al

in Bone Marrow Transplantation (2013, April 08), 48(S2), 132

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See detailInvestigation of potential new targets for the diagnosis and/or the treatment of osteoarthritis
Lambert, Cécile ULg; Dubuc, J.-E.; Montell, E. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

Purpose: Synovial inflammation plays a key role in the pathophysiology process of osteoarthritis (OA). We have previously compared the gene expression pattern of synovial cells isolated from inflammatory ... [more ▼]

Purpose: Synovial inflammation plays a key role in the pathophysiology process of osteoarthritis (OA). We have previously compared the gene expression pattern of synovial cells isolated from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same OA patient. We identified a large number of mediators belonging to key pathways involved in OA pathogenesis. The aim of this study was to validate different potential new targets for the diagnosis and/or the treatment OA. Methods: Synovial cells (SC) were isolated from synovial specimens obtained from OA patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria. The biopsies from N/R and I areas were cultured separately for a period of 7 days. Microarray gene expression profiling between N/R and I areas was performed. The biological relevance of up- and down-regulated genes was analyzed with Ingenuity Pathways Analysis. Western blot and immunohistochemistry confirmed the identified genes most differentially expressed in the key pathways. The production of the triggering receptor expressed on myeloid cells-1 (TREM1), the alarmin S100 calcium binding protein A9 (S100A9), the wingless-type MMTV integration site family, member 5A (Wnt-5A) and the stanniocalcin 1 (STC1) were evaluated by Western blot. S100A9, hyaluronan synthase-1 (HAS1) and STC1 expression and localization were investigated by immunohistochemistry. Results: 896 genes differentially expressed in N/R and I areas were identified. The key pathways were related to inflammation, cartilage metabolism, Wnt signaling and angiogenesis. In the inflammatory gene pattern, TREM1 and S100A9 were strongly upregulated. We validated the production of these proteins in OA synovial biopsies by Western blot. TREM1 and S100A9 were increased in I compared to N/R synovial cells culture. S100A9 was observed in the perivascular area and in sublining cells in I synovial biopsies, but not in N/R biopsies. An increased staining was also observed in the intima lining layer of I when compared to N/R biopsies. The most upregulated anabolism enzyme in I synovial biopsies was HAS1. Using immunohistochemistry, we observed in I areas an increase of the HAS1-positive cells mainly in the intima lining. We also studied the protein production of Wnt-5A, the most upregulated intermediate of Wnt signaling pathway. The protein level was increased in I compared to N/R areas. Finally, in the angiogenesis pathway, one the most u-regulated gene was STC1. A significant increase of STC1 production was observed in I areas compared to N/R areas by Western blot. This result was also supported by the immunohistochemical analysis. In I area, the staining for STC1 was more intense in perivascular and sublining cells. Conclusions: Synovial membrane inflammation is a key target for OA treatments. In this work, we have identified proteins involved in the synovitis pathways like angiogenesis, cells infiltration and matrix remodeling. These proteins could be targeted by drugs and used as companion biomarkers for evaluating their efficacy. Although qualitative, our results could also yield to the identification of markers of the disease. This investigation has to be further pursued. [less ▲]

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See detailSuperior Renal Function Sustained for 24 Months through Early Everolimus-Facilitated Reduction of Tacrolimus Versus Standard Tacrolimus in De Novo Liver Transplant Recipients: Results of a Randomized Trial.
De Simone, Pierre; DETRY, Olivier ULg; Kintmalm, G et al

in American Journal of Transplantation (2013, April), 13(S5), 169450

mTOR inhibitors have the potential to reduce calcineurin inhibitor nephrotoxicity by minimizing or eliminating the need for their use. The 12 month (M) results of H2304 (NCT00622869) study demonstrated ... [more ▼]

mTOR inhibitors have the potential to reduce calcineurin inhibitor nephrotoxicity by minimizing or eliminating the need for their use. The 12 month (M) results of H2304 (NCT00622869) study demonstrated superior renal function with everolimus (EVR) plus reduced tacrolimus (rTAC) vs. standard TAC (TAC-C) in de novo liver transplant recipients (LTxR). Presented here are 24M renal function results. For this 24M, multicenter, open-label study 719 de novo LTxR were randomized (1:1:1) after a 30-day (±5 days) run-in period with TAC (±mycophenolate mofetil), to receive either EVR (C0 3-8 ng/mL) with rTAC (C0 3-5 ng/mL; EVR+rTAC, N=245) or EVR (C0 6-10 ng/mL) with TAC withdrawal (TAC-WD; N=231) at M4 or TAC-C (C0 6-10 ng/mL; TAC-C, N=243); all patients received corticosteroids. Enrollment in TAC-WD arm was stopped early due to higher rejection rates. Main endpoints at M24 included composite ef􏰀cacy failure rate of treated biopsy proven acute rejection, graft loss or death, and evolution of renal function from randomization (RND) to M24 measured as eGFR by MDRD4. At M24, composite ef􏰀cacy failure rate in EVR+rTAC arm was comparable to TAC-C (10.3% vs. 12.5%, p=0.452). Evolution of renal function from RND to M24 was superior for EVR+rTAC vs. TAC-C with an adjusted mean difference in eGFR change of 6.66 mL/min/1.73m2 (p=0.0018; ITT population). Signi􏰀cantly higher eGFR with EVR+rTAC was achieved at M2 post-LTx and was maintained until M24. On-treatment data showed a decrease in mean eGFR from RND to M24 of 6.6 mL/min/1.73m2 with EVR+rTAC vs. 13 mL/min/1.73m2 with TAC-C and 2.5 mL/ min/1.73m2 gain with TAC-WD. Urinary protein:creatinine ratio (mg/g) at M24 was higher with EVR+rTAC vs. TAC-C (Mean±SD: 194±280 vs. 159±284, p=0.006). Early introduction of EVR at 1M post-LTx with rTAC showed superior renal function sustained for 24M compared to TAC-C, without compromising ef􏰀cacy in de novo LTxR. [less ▲]

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See detailReproducibility of joint space width assessment when external calibration on the radiograph is missing
DEROISY, Rita ULg; Reginster, Jean-Yves ULg; Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 379

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See detailMise en oeuvre du Programme de Gestion Durable de l'Azote à l'échelle de deux petits bassins versants (Arquennes - Belgique) et évaluation d'impact par le suivi des flux de nitrate aux exutoires et par modélisation numérique
Deneufbourg, Mathieu ULg; Vandenberghe, Christophe ULg; Gaule, David et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013, April), 17(S1), 164-176

Four water catchments used by the Walloon Society of Water (SWDE) in the rural village of Arquennes (Province of Hainaut, Belgium) have been contaminated by nitrate (concentrations between 60 and 70 mg ... [more ▼]

Four water catchments used by the Walloon Society of Water (SWDE) in the rural village of Arquennes (Province of Hainaut, Belgium) have been contaminated by nitrate (concentrations between 60 and 70 mg NO3-·l-1) for several years. The catchment basins (31 ha and 47 ha) are located exclusively in a cultivated area on loamy soils. Since October 2004, these basins have been used as a pilot area for the environmental evaluation of good agricultural practices as regards nitrogen management (adaptation of amounts of mineral nitrogen fertilizers, farm manure management, soil cover after harvest, etc.) thanks to monitoring by farmers. This approach fits into the general pattern of the Sustainable Nitrogen Management Program (PGDA in French), which implements the European Nitrates Directive as part of Walloon legislation. The second objective of the working scheme is to study and to set up a decision-making tool aimed at preventing the contamination of water by agricultural nitrate around water catchments. Two numerical models (SWAT and FEFLOW®) were used together in order to simulate the passage of water and nitrogen from the soil surface to the water catchments outlets. Calibration and validation of models were based, among other things, on soil and subsoil characterization and on tracer testing in both saturated and unsaturated zones. Moreover crop yield, farming practices, water and nitrate fluxes in water catchments, groundwater levels and nitrate concentration in groundwater were monitored for eight years. The results of simulations show that the application of PGDA in Arquennes watersheds would lead to a decrease in nitrate concentration (to almost 50 mg NO3-·l-1) in water catchments in 2012. This expected improvement in water quality has been visible since 2009 in water catchments, with mean nitrate concentrations of lower than 50 mg NO3-·l-1 at the end of 2012. [less ▲]

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See detailWhat is the predictive value of MRI for the occurrence of hard clinical endpoints in knee osteoarthritis?
Pelletier, Jean-Pierre; Peterfy, Charles; Brandi, Maria Luisa et al

in Osteoporosis International (2013, April), 24(Suppl.1), 84-85

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See detailStrontium ranelate improves osteoarthritis symptoms compared to placebo in patients with knee OA: The SEKOIA study
Bruyère, Olivier ULg; Richette, P; Bellamy, N et al

in Osteoporosis International (2013, April), 24(Suppl.1), 49-51

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See detailPlanet TOPERS: Planets, Tracing the Transfer, Origin, Preservation, and Evolution of Their Reservoirs
Dehant, V.; Van Hoolst, T.; Breuer, D. et al

in Geophysical Research Abstracts (2013, April), 15

An overview is given of the Planet TOPERS project addressing habitability in our solar system.

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See detailThe intra-articular injection of a new chitosan biomaterial prevents the progression of osteoarthritis in ACLT rabbit model
Oprenyeszk, Frédéric ULg; Chausson, Mickael; Maquet, Véronique et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), 69

Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on ... [more ▼]

Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on cartilage lesion in osteoarthritis (OA) rabbit model. These effects were compared to those obtained with the intra-articular injection of either chitosan-based (H) hydrogel without the AC bead or saline solution. Methods OA was surgically induced by the transection of the anterior cruciate ligament (ACLT) in HYLA albino rabbits. One week after surgery, animals were randomly divided into 3 groups: group I (n=7): mix of AC beads and H hydrogel; group II (n=7): H hydrogel alone; group III (n=7): saline solution (control). The treatments (900 µl) were injected intra-articularly. X-rays from the right knee were performed before surgery, at the time of injection and at sacrifice. The standard radiographs were acquired in extension and scored by the Kellgren and Lawrence (K&L) scale. After 6 weeks, animals were euthanized and the right joint was dissected. The macroscopic evaluation of cartilage from femoral condyles and tibial plateaus stained with India ink was done. Histological sections stained with Safranine-O/fast green from bearing areas of each compartment were evaluated according to the OARSI histological score. Briefly, the evaluation considered: staining of the cartilage matrix (0-6), cartilage structure (0-11), chondrocyte density (0-4) and cluster formation (0-3), where 0 represented a normal situation and 24 points the maximum severity score. Blood samples were collected the day of injection and prior the sacrifice. Prostaglandin E2 (PGE2) and C-reactive protein (CRP) were measured in serum using immunoassays. Results The X-rays analysis showed a significant decrease (p <0.05) of the K&L score in group I (AC beads and H hydrogel; 1.5 ± 0.2) compared with group II (H hydrogel; 2.2 ± 0.5) and group III (saline solution; 3.0 ± 0.4). The size and the severity of the macroscopic OA cartilage lesion tended to decrease in group I compared to the other groups. The histological global score that refers to all compartments of the knee joint was significantly decreased in group I (11.0 ± 0.7) compared to group II (14.4 ± 0.6, p <0.01) and group III (14.8 ± 0.6, p <0.001). No significant variation of PGE2 and CRP serum levels were observed in each after 6 weeks follow-up whatever the treatment injected. Conclusions This study showed that a biphasic hydrogel composed by AC beads and H hydrogel prevented OA in rabbit with ACL transection. This effect was not observed with the hydrogel alone, suggesting that AC beads play a role in joint protection. The preventive effect was observed in all joint compartments indicating a global protective effect of this new viscosupplementation. [less ▲]

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See detailClinical characteristics of patients responsive to whole body vibration
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Maquet, Didier ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 243

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See detailEvaluation of the impact of a 6-month training by whole body vibration on the risk of falls among nursing home residents
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Demonceau, Marie ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 246-247

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See detailOARSI recommended performance-based tests to assess physical function in people with established hip and knee osteoarthritis
Dobson, F.; Hinman, R.S.; Roos, E.M. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

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See detailOrthanc - A lightweight, RESTful DICOM server for healthcare and medical research
JODOGNE, Sébastien ULg; Bernard, Claire ULg; DEVILLERS, Magali ULg et al

in Proceedings, IEEE International Symposium on Biomedical Imaging: from Nano to Macro (2013, April)

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See detailQuality of life in sarcopenia and frailty
Rizzoli, René; Reginster, Jean-Yves ULg; Arnal, Jean-François et al

in Osteoporosis International (2013, April), 24(Suppl.1), 76-77

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See detailEffects of chondroitin sulfate on the gene expression profile in the inflamed synovial membrane
Lambert, Cécile ULg; Dubuc, J-E; Montell, E. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a ... [more ▼]

Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a second step, we investigated the genetic modulatory effects of chondroitin sulfate (CS) in this model. Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days in the absence or in the presence of highly purified bovine CS (200 µg/ml, Bioibérica S.A., Barcelona, Spain). Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I conditions, N/R and N/R-CS conditions and I and I-CS conditions was based on paired t-test where N/R and I, N/R and N/R-CS and I and I-CS were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Results: From among 47000 probes, 18253 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 465 differentially expressed genes between N/R and I areas were identified. Many inflammatory mediators appear differentially expressed. The interferon alpha-inductible protein 6 (IFI6) was the most up-regulated. We also identified the hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), the cathepsin K (CTSK), the chemokine (C-X-C motif) ligand 1 (CXCL1) and the EBV-induced G-protein coupled receptor 2 (EBI2). The differential expression of intermediates involved in angiogenesis pathway was also revealed between N/R and I areas. Among them, R-spondin-3 (RSPO3), the secreted phopshoprotein 1 (SPP1) and aquaporin 9 (AQP9) were up-regulated whereas ADAMTS1 was down-regulated. Finally, in the Wnt signaling, RSPO3 was up-regulated unlike dickkopf homolog 3 (DKK3) which was in turn down-regulated. We next performed a class comparison test between N/R and N/R-CS in one hand and between I and I-CS the other hand. 489 genes were identified as differentially expressed genes between N/R and N/R-CS conditions while 219 genes were identified between I and I-CS conditions. In this latter, our attention was focused on the down-regulated genes. Among them, we identified a number implicated in angiogenesis and cell migration pathways. Thus, the endothelial cell-specific molecule-1 (ESM1), the Transmembrane-4-L-six-family-1 (TM4SF1), the 5’-Ectonucleotidase (NT5E) and the growth arrest-specific gene 6 (GAS6) were down-regulated by CS. Conclusions: Our work demonstrates the differential gene expression profile between paired non inflammatory and normal/reactive areas of synovial membrane as well as the modulatory effects of CS on gene expression in the inflammatory areas, especially regarding genes involved in both angiogenesis and cell migration. [less ▲]

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of postmenopausal women
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Rabenda, Véronique ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 198

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See detailHealth economics in osteoarthritis
Hiligsmann, Mickaël ULg; Cooper, Cyrus; Arden, Nigel et al

in Osteoporosis International (2013, April), 24(Suppl.1), 79-80

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See detailValidity of the French hip and knee replacement expectations surveys
NEUPREZ, Audrey ULg; François, Garance ULg; Delcour, JP et al

in Osteoporosis International (2013, April), 24(Suppl.1), 374

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See detailScalar triplet leptogenesis without right-handed neutrino decoupling
Aristizabal Sierra, Diego ULg

in Nuclear Physics B Proceedings Supplement (2013, April), 237-238

We discuss leptogenesis in the context of type-II seesaw in the case in which in addition to the scalar electroweak triplet decays the lepton asymmetry is also induced by right-handed neutrino decays ... [more ▼]

We discuss leptogenesis in the context of type-II seesaw in the case in which in addition to the scalar electroweak triplet decays the lepton asymmetry is also induced by right-handed neutrino decays (mild hierarchical scenarios). We show that within this setup, depending on the relative sizes of the relevant parameters, one can identify three classes of generic models, each one with its own consequences for leptogenesis. [less ▲]

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See detailQuantitative gait assessment using an accelerometer technology as a predictive tool of falls among nursing home residents: a 6-month prospective study
Bruyère, Olivier ULg; Detalle, Anne-Sophie; Demonceau, Marie ULg et al

in Osteoporosis International (2013, April), 24(Suppl.1), 210

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See detailEffects of chondroitin sulfate on the gene expression profile in the inflamed synovial membrane
Lambert, Cécile ULg; Dubuc, J-E; Montell, E. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a ... [more ▼]

Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a second step, we investigated the genetic modulatory effects of chondroitin sulfate (CS) in this model. Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days in the absence or in the presence of highly purified bovine CS (200 µg/ml, Bioibérica S.A., Barcelona, Spain). Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I conditions, N/R and N/R-CS conditions and I and I-CS conditions was based on paired t-test where N/R and I, N/R and N/R-CS and I and I-CS were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Results: From among 47000 probes, 18253 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 465 differentially expressed genes between N/R and I areas were identified. Many inflammatory mediators appear differentially expressed. The interferon alpha-inductible protein 6 (IFI6) was the most up-regulated. We also identified the hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), the cathepsin K (CTSK), the chemokine (C-X-C motif) ligand 1 (CXCL1) and the EBV-induced G-protein coupled receptor 2 (EBI2). The differential expression of intermediates involved in angiogenesis pathway was also revealed between N/R and I areas. Among them, R-spondin-3 (RSPO3), the secreted phopshoprotein 1 (SPP1) and aquaporin 9 (AQP9) were up-regulated whereas ADAMTS1 was down-regulated. Finally, in the Wnt signaling, RSPO3 was up-regulated unlike dickkopf homolog 3 (DKK3) which was in turn down-regulated. We next performed a class comparison test between N/R and N/R-CS in one hand and between I and I-CS the other hand. 489 genes were identified as differentially expressed genes between N/R and N/R-CS conditions while 219 genes were identified between I and I-CS conditions. In this latter, our attention was focused on the down-regulated genes. Among them, we identified a number implicated in angiogenesis and cell migration pathways. Thus, the endothelial cell-specific molecule-1 (ESM1), the Transmembrane-4-L-six-family-1 (TM4SF1), the 5’-Ectonucleotidase (NT5E) and the growth arrest-specific gene 6 (GAS6) were down-regulated by CS. Conclusions: Our work demonstrates the differential gene expression profile between paired non inflammatory and normal/reactive areas of synovial membrane as well as the modulatory effects of CS on gene expression in the inflammatory areas, especially regarding genes involved in both angiogenesis and cell migration. [less ▲]

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See detailWhat is the value of biomarkers for drug development in osteoarthritis?
Lotz, Martin; Martel-Pelletier, Johanne; Christiansen, Claus et al

in Osteoporosis International (2013, April), 24(Suppl.1), 77-78

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See detailRole of nutraceuticals in the symptomatic and structural management of osteoarthritis
Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 82-83

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See detailChanges in the structure and the symptoms of the osteoarthritis knee and prediction of future knee replacement over an 8-year follow-up period
Bruyère, Olivier ULg; Cooper, Cyrus; Pavelka, Karel et al

in Osteoporosis International (2013, April), 24(Suppl.1), 209

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See detailNonpharmacological management
Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 76

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See detailEffects of chondroitin sulfate on the gene expression profile in IL-1β stimulated synovial fibroblast cells cultures
Lambert, Cécile ULg; Dubuc, Jean-Emile; Montell, E. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. In this study, we performed a microarray analysis and identified a differential expression profile between control ... [more ▼]

Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. In this study, we performed a microarray analysis and identified a differential expression profile between control and IL-1β stimulated synovial fibroblast cells cultures. In a second step, we investigated the effects of CS on this gene expression profile. Methods: OA synovial specimens were obtained from 12 patients undergoing knee replacement. At the surgery time, the synovial membrane was dissected. Synovial fibroblast cells (SFC) were enzymatically isolated and used after four passages (P4). SFC were pre-treated 1 hour with highly purified bovine CS (200 µg/ml, Bioibérica S.A., Barcelona, Spain) before treatment with IL-1β (1 ng/ml) for 24 hours. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class comparison test between control (Ctl) and interleukin (IL)-1β conditions, Ctl and Ctl/CS and IL-1β and IL-1β/CS conditions was based on paired t-test where Ctl and IL-1β, Ctl and Ctl/CS and IL-1β and IL-1β/CS were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Probes with a p-value below 0.001 were chosen and classified as up- or down-regulated ones. Results: 3308 genes were identified as differentially expressed genes between Ctl and IL-1β conditions. We observed a differential profile of expression of major pathways involved in OA pathogenesis. The key identified pathways were related to inflammation, complement cascade, angiogenesis, cartilage catabolism and anabolism and Wnt signaling. In the inflammatory network, the most upregulated cytokines were IL-8 and IL-6 with a fold change of 156.25 and 58.8 respectively. We also identified several chemokines, enzymes and metallothioneins (MTs). Complement factor B (CFB) and complement component 3 (C3) are two factors upregulated in the inflammatory complement cascade. We also identified some genes implicated in the angiogenesis pathway. The most upregulated was Stanniocalcin 1 (STC1) with a fold change of 9.09. The differential expression of intermediates involved in both cartilage anabolism and catabolism was revealed by the IL-1β stimulation, showing an imbalance in favour of catabolism. MMP-3 was largely upregulated (fold change of 62.5). Wnt 5A and low density lipoprotein receptor-related protein (LRP8) were significantly upregulated while frizzled homolog 2 (FZD2) and dickkopf homolog 3 (DKK3) were downregulated in the Wnt signaling pathway. We next performed a class comparison test between Ctl and Ctl/CS in one hand and IL-1β and IL-1β/CS on the other hand. 660 genes were identified as differentially expressed between Ctl and Ctl/CS conditions while 241 genes were identified between IL-1β and IL-1β/CS. Among them, our attention was focused on two genes upregulated in the presence of CS: lysyl oxidase-like 4 (LOXL4) and claudin 11 (CDLN11), two genes that negatively regulate cell invasion. Conclusions: We here evidenced in synovial fibroblast cells the modulation of gene expression following IL-1β stimulation. We also demonstrated the modulatory effects of CS on gene expression and isolated several CS-modulated genes of interest such as LOXL4 and CDLN11, which could constitute new mechanisms of action of the molecule and contribute to explain the symptomatic efficacy of CS in the treatment of OA. [less ▲]

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See detailRed giants rotational splittings
Ouazzani, R. M.; Goupil, M. J.; Dupret, Marc-Antoine ULg et al

in EPJ Web of Conferences (2013, March 01), 43

The space missions CoRoT and Kepler provide high quality data that allow to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. Our aim is to ... [more ▼]

The space missions CoRoT and Kepler provide high quality data that allow to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. Our aim is to test the validity of the seismic diagnostics for red giant rotation that are based on a perturbative method and to investigate the oscillation spectra when the validity does not hold. We use a non-perturbative approach implemented in the ACOR code [1] that accounts for the effect of rotation on pulsations, and solves the pulsations eigenproblem directly for dipolar oscillation modes. We find that the limit of the perturbation to first order can be expressed in terms of the core rotation and the period separation between consecutive dipolar modes. Above this limit, each family of modes with different azimuthal symmetry m, has to be considered separately. For rapidly rotating red giants, new seismic diagnostics can be found for rotation by exploiting the differences between the period spacings associated with each m-family of modes. [less ▲]

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See detailNon-radial, non-adiabatic solar-like oscillations in RGB and HB stars
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, K. et al

in EPJ Web of Conferences (2013, March 01), 43

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in ... [more ▼]

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in the same region of the HR diagram but in different evolutionary phases. We present here our first results on the inertia, lifetimes and amplitudes of the oscillations and discuss the differences between the two stars. [less ▲]

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See detailMode lifetime and associated scaling relations
Belkacem, K.; Appourchaux, T.; Baudin, F. et al

in EPJ Web of Conferences (2013, March 01), 43

Thanks to the CoRoT and Kepler spacecrafts, scaling relations (linking seismic indices and global stellar parameters) are becoming the cornerstone of ensemble asteroseismology. Among them, the relation ... [more ▼]

Thanks to the CoRoT and Kepler spacecrafts, scaling relations (linking seismic indices and global stellar parameters) are becoming the cornerstone of ensemble asteroseismology. Among them, the relation between the cut-off frequency and the frequency of the maximum in the power spectrum of solar-like pulsators as well as the relation between mode lifetime and the effective temperature remain poorly understood. However, a solid theoretical background is essential to assess the accuracy of those relations and subsequently of the derived stellar parameters. We will thus present recent advances on the understanding of the underlying mechanisms governing those relations and show that the physics of mode lifetime (thus of mode damping) plays a major role. [less ▲]

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See detailAmplitudes of solar-like oscillations in red giants: Departures from the quasi-adiabatic approximation
Samadi, R.; Belkacem, K.; Dupret, Marc-Antoine ULg et al

in European Physical Journal Web of Conferences (2013, March 01), 43

CoRoT and Kepler measurements reveal us that the amplitudes of solar-like oscillations detected in red giant stars scale from stars to stars in a characteristic way. This observed scaling relation is not ... [more ▼]

CoRoT and Kepler measurements reveal us that the amplitudes of solar-like oscillations detected in red giant stars scale from stars to stars in a characteristic way. This observed scaling relation is not yet fully understood but constitutes potentially a powerful diagnostic about mode physics. Quasi-adiabatic theoretical scaling relations in terms of mode amplitudes result in systematic and large differences with the measurements performed for red giant stars. The use of a non-adiabatic intensity-velocity relation derived from a non-adiabatic pulsation code significantly reduces the discrepancy with the CoRoT measurements. The origin of the remaining difference is still unknown. Departure from adiabatic eigenfunction is a very likely explanation that is investigated in the present work using a 3D hydrodynamical model of the surface layers of a representative red giant star. [less ▲]

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See detailStockage de bois chablis sous bâche
Castaings, Frédéric; Jourez, Benoît ULg; Riguelle, Simon ULg

in Infos de RND (Les) (2013, March), (1er semestre), 3-5

Le samedi 24 janvier 2009, la tempête Klaus traverse le sud-ouest de la France. Tempête la plus dévastatrice depuis 1999, la forêt des Landes et ses pins maritimes paient un lourd tribut à ce phénomène ... [more ▼]

Le samedi 24 janvier 2009, la tempête Klaus traverse le sud-ouest de la France. Tempête la plus dévastatrice depuis 1999, la forêt des Landes et ses pins maritimes paient un lourd tribut à ce phénomène extrême: 60% de la superficie est touchée, environ 40 millions de m3 de bois sont à terre, quatre fois la récolte annuelle. Il faudra attendre plusieurs mois avant que les aires de stockage par aspersion soient opérationnelles. Trop tard, le pin maritime montre déjà des signes de bleuissement de son bois, il est invendable sur les marchés à forte valeur ajoutée, là où l’esthétisme prime. Écarté des meilleurs débouchés, le lambris et le plancher, le manque à gagner est énorme. Un tel scénario catastrophe, notre région s’y prépare depuis 2005, tirant les enseignements des expériences étrangères et fondant son action sur les spécificités de notre forêt, de notre filière. C’est dans ce cadre que le 28 février dernier, à Eupen, des grumes d’épicéa stockées depuis presque cinq ans ont été extraites des bâches hermétiques qui les protégeaient. Comment le bois est-il ressorti de cette épreuve? Que penser de cette méthode alternative de stockage? Quelle place lui réserver ? Benoit Jourez du Laboratoire de Technologie du Bois du DEMNA (Département de l’Étude du milieu naturel et agricole) nous a apporté son éclairage et nous a conviés à l’ouverture de la poche étanche. Entre supputations et réalité des bois extraits après cinq ans, suspense… [less ▲]

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See detailAsteroseismology of hot B subdwarf stars
Charpinet, Stéphane; Van Grootel, Valérie ULg; Brassard, Pierre et al

in EPJ Web of Conferences (2013, March), 43

Nonradial pulsations in Extreme Horizontal Branch stars (also known as hot B subdwarfs or sdB stars) offer strong opportunities to study through asteroseismology the structure and internal dynamics of ... [more ▼]

Nonradial pulsations in Extreme Horizontal Branch stars (also known as hot B subdwarfs or sdB stars) offer strong opportunities to study through asteroseismology the structure and internal dynamics of stars in this intermediate stage of stellar evolution. Most sdB stars directly descend from former red giants and are expected to evolve straight into white dwarfs after core helium exhaustion. They thus represent the most direct link between these two stages. Their properties should therefore reflect both the outcome of the core evolution of red giant stars and the initial state for a fraction of the white dwarfs. We review the status of this field after a decade of efforts to exploit both p-mode and g-mode pulsating sdB stars as asteroseismic laboratories. From the discoveries of these two classes of pulsators in 1997 and 2003, respectively, up to the current epoch of data gathering of unprecedented quality from space, a lot of progress has been made in this area and prospects for future achievements look very promising. [less ▲]

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See detailBelgian multicentre experience with intestinal transplantation
Ceulemans, L; DE ROOVER, Arnaud ULg; DETRY, Olivier ULg et al

in Acta Gastro-Enterologica Belgica (2013, March), 76(1), 07

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See detailAn overview of white dwarf stars
Fontaine, Gilles; Brassard, Pierre; Charpinet, Stéphane et al

in EPJ Web of Conferences (2013, March), 43

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of ... [more ▼]

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of stellar evolution for the vast majority of stars and, as such, bear the signatures of past events (such as mass loss, mixing phases, loss and redistribution of angular momentum, and thermonuclear burning) that are of essential importance in the evolution of stars in general. In addition, white dwarf stars represent ideal testbeds for our understanding of matter under extreme conditions, and work on their constitutive physics (neutrino production rates, conductive and radiative opacities, interior liquid/solid equations of state, partially ionized and partially degenerate envelope equations of state, diffusion coefficients, line broadening mechanisms) is still being actively pursued. Given a set of constitutive physics, cooling white dwarfs can be used advantageously as cosmochronometers. Moreover, the field has been blessed by the existence of four distinct families of pulsating white dwarfs, each mapping a different evolutionary phase, and this allows the application of the asteroseismological method to probe and test their internal structure and evolutionary state. We set the stage for the reviews that follow on cooling white dwarfs as cosmochronometers and physics laboratories, as well as on the properties of pulsating white dwarfs and the asteroseismological results that can be inferred. [less ▲]

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See detailDifférences d’activité de l’inflammasome NLRP3 entre sujets obèses avec et sans anomalies métaboliques
Esser, Nathalie ULg; L'Homme, Laurent ULg; DE ROOVER, Arnaud ULg et al

in Diabètes & Métabolism (2013, March), 39(suppl 1), 102

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See detailThe empirical mass distribution of hot B subdwarfs: implications for stellar evolution theory
Van Grootel, Valérie ULg; Fontaine, Gilles; Charpinet, Stéphane et al

in EPJ Web of Conferences (2013, March), 43

Subdwarf B (sdB) stars are hot, compact, and evolved objects that form the very hot end of the horizontal branch, the so-called Extreme Horizontal Branch (EHB). Understanding the formation of sdB stars is ... [more ▼]

Subdwarf B (sdB) stars are hot, compact, and evolved objects that form the very hot end of the horizontal branch, the so-called Extreme Horizontal Branch (EHB). Understanding the formation of sdB stars is one of the remaining challenges of stellar evo- lution theory. Several scenarios have been proposed to account for the existence of such objects, made of He-burning core surrounded by very thin H-rich envelope. They give quite different theoretical mass distributions for the resulting sdB stars. Detailed astero- seismic analyses, including mass estimates, of 15 pulsating hot B subdwarfs have been published since a decade. The masses have also been reliably determined by light curve modeling and spectroscopy for 7 sdB components of eclipsing and/or reflection effect binaries. These empirical mass distributions, although based on small-number statistics, can be compared with the expectations of stellar evolution theory. In particular, the two He white dwarfs merger scenario does not seem to be the dominant channel to form iso- lated sdB stars, while the post-red giant branch scenario is reinforced. This opens new questions on extreme mass loss of red giants to form EHB stars, possibly in connection with the recently discovered close substellar companions and planets orbiting sdB stars. [less ▲]

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See detailDevelopment of an experimental device allowing plant-plant interaction studies and in situ dynamic trapping of volatile organic compounds emitted by barley (Hordeum distichon L.) roots
Delory, Benjamin ULg; Delaplace, Pierre ULg; Fauconnier, Marie-Laure ULg et al

in Communications in Agricultural and Applied Biological Sciences (2013, February 08), 78(1), 97-102

In response to wounding or herbivore attack, leaves and roots of higher plants release volatile organic compounds (VOCs). To date, VOCs analysis and plant−plant interaction studies have been mainly ... [more ▼]

In response to wounding or herbivore attack, leaves and roots of higher plants release volatile organic compounds (VOCs). To date, VOCs analysis and plant−plant interaction studies have been mainly performed on aboveground plant tissues, leaving the roles played by root VOCs in plant−plant interaction unexplored. In this context, this project aims at setting up an original experimental device allowing both dynamic trapping of VOCs emitted by mechanically damaged H. distichon roots and the study of the roles played by root VOCs in intra and interspecific plant−plant interactions. The experimental device consists of Barley seedlings cultivated in closed PTFE reactors filled with wet sand. Before being analysed by gas chromatography−mass spectrometry, root VOCs are trapped via a dynamic system on Tenax cartridges using a charcoal-filtered and humidified air. Preliminary results show that 7 day-old wounded Barley roots emit C9 fatty acid derivatives (E-non-2-enal and nona-2,6-dienal) as major compounds, contrasting with aboveground plant tissues that mainly emit C6 alcohols, aldehydes, and their derivative esters. For plant−plant interaction studies, receiver plants are exposed to an airflow enriched with VOCs from root damaged Barley plants of the same age. [less ▲]

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See detailLong term measurements of volatile organic compounds exchanges above a maize field at Lonzee (Belgium)
Bachy, Aurélie ULg; Aubinet, Marc ULg; SALERNO, Giovanni ULg et al

in Communications in Agricultural and Applied Biological Sciences (2013, February), 78(1), 127-132

VOC (volatile organic compounds) include a wide set of molecules which are mostly emitted by the plants. Atmospheric scientists are strongly interested in these compounds because of their important role ... [more ▼]

VOC (volatile organic compounds) include a wide set of molecules which are mostly emitted by the plants. Atmospheric scientists are strongly interested in these compounds because of their important role in the atmospheric chemistry and their final impact on air pollution and climate change. Evaluation of current and future VOC emissions is thus necessary and requires a comprehensive understanding of VOC production and exchange dynamics under a wide panel of climatic conditions and ecosystems. Forest and non pastured grasslands have been largely studied for the last decade. However, knowledge about VOC fluxes from croplands remains scarce. Our study focuses on the VOC exchanges between a maize field and the atmosphere. It is incorporated in a wider project that aims to study VOC fluxes from two croplands (maize and winter wheat) and a pastured grassland. VOC fluxes have been measured on a maize field during the whole growing season using a micrometeorological method (eddy covariance). While first results show half-hourly bidirectionnal exchanges among all the preselected compounds, in average methanol stands for the greatest emitted VOC, followed by green leaf volatiles, and acetic acid is the greatest taken up VOC. Small isoprene and monoterpenes fluxes are also observed. A diurnal pattern is found for all those VOC, with greater emission/uptake during the day, suggesting a flux dependence on environmental parameters. These environmental controls will be further investigated [less ▲]

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See detailLepton flavor violation and seesaw symmetries
Aristizabal Sierra, Diego ULg

in Hyperfine Interactions (2013, February), 214

When the standard model is extended with right-handed neutrinos the symmetries of the resulting Lagrangian are enlarged with a new global U(1)R Abelian factor. In the context of minimal seesaw models we ... [more ▼]

When the standard model is extended with right-handed neutrinos the symmetries of the resulting Lagrangian are enlarged with a new global U(1)R Abelian factor. In the context of minimal seesaw models we analyze the implications of a slightly broken U(1)R symmetry on charged lepton flavor violating decays. We find, depending on the R-charge assignments, models where charged lepton flavor violating rates can be within measurable ranges. In particular, we show that in the resulting models due to the structure of the light neutrino mass matrix muon flavor violating decays are entirely determined by neutrino data (up to a normalization factor) and can be sizable in a wide right-handed neutrino mass range. [less ▲]

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See detailErythropoietin therapy after allogeneic hematopoietic cell transplantation : a prospective randomised trial.
JASPERS, Aurélie ULg; Baron, Frédéric ULg; WILLEMS, Evelyne ULg et al

in Belgian Journal of Hematology (2013, January)

Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO ... [more ▼]

Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO) therapy was very efficient when started one month after transplantation. We also demonstrated that anemia after nonmyeloabalative (NM) HCT was less sensitive to rhEPO therapy than after conventional allogeneic HCT. This prompted us to confirm these findings in a prospective randomised trial. One hundred and thirty-one patients were randomised (1:1) between no treatment (arm 1) or erythropoietin (Neorecormon) at the dose of 500 U/kg/week (arm 2). Once the target Hb (13g/dL) has been attained, the dose of rhEPO was reduced by half, while it was withheld when Hb was = 14g/dL. Cohort A included 42 patients on day 28 after myeloablative HCT, cohort B 39 patients on day 28 after NMHCT, and cohort C 50 patients on day 0 of NMHCT. Primary endpoints included proportion of complete correctors (i.e. patients reaching Hb = 13g/dL) and median time to achieve Hb correction in each arm. The proportion of complete correctors before day 126 posttransplant was 0% in group 1A vs 52.4% in group 2A, 0% in group 1B vs 69.5% in group 2B and 19.1% in group 1C vs 70.2% in group 2C. Median time to achieve Hb = 13g/dL was not reached in group 1B vs 49 days in group 2B; 363 and 59 days in groups 1A and 1B respectively and 363 and 87 days in groups 3A and 3B respectively (figure 1). Hb evolution in each group is shown in figure 2. Seventyone patients (47/62 in control groups and 24/57 in treated groups, p=0.0003) required red blood cell transfusions. The difference was most pronounced in cohort B. There was no difference in rates of thrombo-embolic events or other complications between the two arms. In conclusion, this is the first trial to demonstrate that EPO therapy hastens erythroid recovery and decreases transfusion requirements when started one month after allogeneic HCT. [less ▲]

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See detailCollaborations distantes synchrones dans les pratiques de conception
Ben Rajeb, Samia ULg; Leclercq, Pierre ULg

in International Journal of Design Sciences and Technology (2013, January)

Cet article propose une analyse des pratiques de la collaboration architecturale dans des situations de travail distantes. Il s'intéresse en particulier à la mise en oeuvre d'outils pour le travail ... [more ▼]

Cet article propose une analyse des pratiques de la collaboration architecturale dans des situations de travail distantes. Il s'intéresse en particulier à la mise en oeuvre d'outils pour le travail synchrones dans les agences d'architecture. Il s'appuie sur l'observations in situ de trois situations qui illustrent successivement différents modes d'interaction : nous analyserons ainsi l'usage de la visioconférence, de l'écran partagé puis du studio distant collaboratif. Pour identifier quels rôles peuvent assurer ces différents outils numériques, notre méthodologie s'appuiera sur la catégorisation proposée par les concepts architecturologiques, décrivant les opérations de conception architecturale, complétées des opérations pragmatiques de collaboration. Une grille évaluative des opérations supportées respectivement par ces trois technologies identifiera leurs limitations, atouts et conditions d'opérabilité, permettant ainsi d'apprécier la mise en oeuvre actuelle et future des technologies collaboratives en agence d'architecture. [less ▲]

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See detailImportance of LUC and ILUC on the carbon footprint of bioproduct:case of bio-HDPE
Belboom, Sandra ULg; Léonard, Angélique ULg

in International seminar on society and materials (2013)

Due to the depletion of fossil fuels and the increase of greenhouse gas emissions, solutions are needed to replace petrol based products. As a consequence, the number of biobased products developed using ... [more ▼]

Due to the depletion of fossil fuels and the increase of greenhouse gas emissions, solutions are needed to replace petrol based products. As a consequence, the number of biobased products developed using agricultural feedstock is continuously increasing. This study focuses on the carbon footprint of bio-HDPE produced either from Brazilian sugar cane or Belgian sugar beet. The goal of this study is to compare the carbon footprint of bio-HDPE with the fossil one, taking into account the effect of land use change. Common boundaries of the agricultural systems comprise the cultivation step for both crops, i.e. sugar cane and sugar beet, with all associated energy and fertilizer consumptions, the transportation step from field to the industrial plant, the sugar crops transformation into hydrate bioethanol, the by-products valorisation, the dehydration and polymerization steps and the HDPE incineration as end of life issue. Fossil scenario includes the production of ethylene, its polymerization and its incineration. When comparing the entire life cycle of bio and fossil HDPE, the GHG emissions are lower for the biobased product which is the willing effect. This result is only valid if no Land Use Change (LUC) or Indirect Land Use Change (ILUC) effect appears. To assess the environmental impact of the deforestation or of the transformation of a pasture into a field, the EC-Guidelines from the European Union were used in order to calculate the CO2 emissions depending on several parameters. For sugar cane, LUC consists in the transformation of pastures into fields in the region of Sao Paulo in Brazil. Three scenarios can be developed based on different agricultural practices for pasture and field (tillage and fertilizers inputs): the best, the worst and the average. The best case leads to a supplementary environmental gain. The worst and average achieve additional emissions. A payback time, considering the time needed to find again an environmental gain compared to the fossil counterpart, was calculated for the average scenario which is equal to 12 years. The ILUC effect for sugar cane is assumed to be deforestation due to the transformation of forest into pasture induced by the previous LUC effect. The rate of deforestation can vary between 16% or 100% depending on used statistics and leads to a payback time of respectively 26 and 101 years. For sugar beet, no LUC is considered. Indeed, no land expansion is available in Belgium due to small available areas. In the case of an increase of bioplastics production, Belgium should import sugar beet from neighboring countries which can induce ILUC. In this study, sugar beet is assumed to be provided by the Netherlands on pastures previously transformed into fields. The average scenario implies a payback time of 8 years. This study permits to highlight the importance of LUC and ILUC especially for energetic crops dedicated to replace fossil products. This effect can reverse expected results and induce long payback times. [less ▲]

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See detailStrontium ranelate prevents radiological progression in patients with primary knee osteoarthritis
Cooper, C; Berembaum, F; Nash, P et al

in Osteoporosis International (2013), 24(1), 306-307

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See detailDeciphering the role of 75KDA SIRT1 fragment in osteoarthritis
Dvir-Ginzberg, M; Oppenheimer, H; Meir, H et al

in Osteoarthritis and Cartilage (2013), 21

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See detailMise en image du spectacle et spectacularisation de l’image à l’âge baroque
Delfosse, Annick ULg; Dekoninck, Ralph; Delbeke, Maarten et al

in Degrés : Revue de Synthèses à Orientation Sémiologique (2013)

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See detailInitiation of methane turbulent flux measurements over a grazed grassland in Belgium
Dumortier, Pierre ULg; Aubinet, Marc ULg; Chopin, Henri ULg et al

in Geophysical Research Abstracts (2013), 15

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See detailVisean corals from the transverse Jebel Begaa to Gara el Itima (eastern Tafilalt, Morocco)
Aretz, Markus; Denayer, Julien ULg

in Document de l'Institut Scientifique, Rabat (2013), 26

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See detailSelf-shuffling words
Charlier, Emilie ULg; Kamae, Teturo; Puzynina, Svetlana et al

in Lecture Notes in Computer Science (2013)

In this paper we introduce and study a new property of infinite words which is invariant under the action of a morphism: We say an infinite word x, defined over a finite alphabet A, is self-shuffling if x ... [more ▼]

In this paper we introduce and study a new property of infinite words which is invariant under the action of a morphism: We say an infinite word x, defined over a finite alphabet A, is self-shuffling if x admits factorizations: x=\prod_{i=1}^\infty U_iV_i=\prod_{i=1}^\infty U_i=\prod_{i=1}^\infty V_i with U_i,V_i \in \A^+. In other words, there exists a shuffle of x with itself which reproduces x. The morphic image of any self-shuffling word is again self-shuffling. We prove that many important and well studied words are self-shuffling: This includes the Thue-Morse word and all Sturmian words (except those of the form aC where a is a letter and C is a characteristic Sturmian word). We further establish a number of necessary conditions for a word to be self-shuffling, and show that certain other important words (including the paper-folding word and infinite Lyndon words) are not self-shuffling. In addition to its morphic invariance, which can be used to show that one word is not the morphic image of another, this new notion has other unexpected applications: For instance, as a consequence of our characterization of self-shuffling Sturmian words, we recover a number theoretic result, originally due to Yasutomi, which characterizes pure morphic Sturmian words in the orbit of the characteristic. [less ▲]

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See detailStudy of a solar concentrator for space based on a diffractive/refractive optical combination
Michel, Céline ULg; Loicq, Jerôme ULg; Languy, Fabian ULg et al

in AIP Conference Proceedings (2013), (1556), 97-100

This paper presents a new design of a planar solar concentrator for space applications focusing on two spatially separated PV cells, allowing independent control of output power of each cell. It has the ... [more ▼]

This paper presents a new design of a planar solar concentrator for space applications focusing on two spatially separated PV cells, allowing independent control of output power of each cell. It has the advantages of both spectral splitting and solar concentration by the combination of a blaze transmission diffraction grating and a flat cylindrical Fresnel lens. An optical optimization has been realized and two variations of configuration have been developed to improve tracking tolerance: first, a design completed by secondary reflective concentrators and second, a symmetrical configuration composed of two lenses. First numerical results are presented, highlighting the possibility to design a concentrator at about 10×, with an electrical output power about 290W/m² lens and less than 10% losses for tracking errors lower than ±0.9°. [less ▲]

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See detailImaging osteoarthritis using (18F)FPRGD2 PET/CT : observation and potential application.
WITHOFS, Nadia ULg; ALVAREZ MIEZENTSEVA, Victoria ULg; SIMONI, Paolo ULg et al

in Journal of Nuclear Medicine (The) (2013), 54(SUPPL), 250

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See detailPrediction of residual stresses by FE simulations on bimetallic work rolls during cooling
Neira Torres, Ingrid ULg; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in Computer Methods in Materials Science (2013), 13(1), 84-91

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic ... [more ▼]

Bimetallic rolls used in the roughing stands of the Hot Strip Mill require mixed properties as a high wear resistance for the shell material and an enhanced toughness for the core material. The bimetallic roll studied in this paper is obtained from a vertical spin casting process followed by cooling and subsequent heat treatments. Failure of the compound roll sometimes occurs during the cooling stage of the casting route or later during the thermal treatments. It requires to deeply investigate the thermo mechanical metallurgical interactions generated during cooling and heat treatment in order to find the origin of cracks. For this purpose, a thermo metallurgic mechanical finite element model is used. However these numerical simulations require a high amount of mechanical, thermal and metallurgical parameters. In order to determinate these parameters, a study of available data for estimation of mechanical parameters was performed. Thermo physical parameters were obtained by DTA and DSC methods. Metallurgical characterization by inverse numerical method based on available CCT diagrams was performed to determine the TTT diagrams. First cooling numerical simulations are presented, allowing a rough estimate of residual stresses values and the identification of key parameters for predicting accurate residual stresses by sensitivity analysis. [less ▲]

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See detailStrontium ranelate effect on knee osteoarthritis progression : a MRI analysis
Genant, HK; Zaim, S; Guermazi, A et al

in Osteoporosis International (2013), 24(1), 312-313

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See detailPrognostic value of FDG PET/CT in patients with hepatocellular carcinoma treated with liver transplantation.
GOVAERTS, L.; DETRY, Olivier ULg; BLETARD, Noëlla ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2013), 2013(SUPPL), 287

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See detailThe Immunomodulating Peptide Thymosin Alpha 1 Has no Effect on Multiple Myeloma Evolution and on Immune Reconstitution
Binsfeld, Marilène ULg; Otjacques, Eléonore ULg; Hannon, Muriel ULg et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 41

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See detailLevels of Dechloranes and PBDEs in Serum from Central European Population
Brasseur, Catherine ULg; Focant, Jean-François ULg

in Organohalogen Compounds (2013), 75

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See detailStudy on the sensitivity of three oat varieties to the saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae)
Censier, Florence ULg; Chavalle, Sandrine; San Martin y Gomez, Gilles et al

in Communications in Agricultural and Applied Biological Sciences (2013), 78(2), 287-292

The saddle gall midge, Haplodiplosis marginata (von Roser, 1840) is a univoltine pest of cereals which occurs in Europe. The larvae feed on stems and attractive saddle-shaped depressions, driving to ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser, 1840) is a univoltine pest of cereals which occurs in Europe. The larvae feed on stems and attractive saddle-shaped depressions, driving to important yield losses when the galls are numerous. After 40 years without any reporting, large populations of H. marginata and important damage have been observed since 2010 in wheat crops in Belgium, especially in the Flemish Polders where clay soils and intensive farming of cereals favour heavy infestations. According to some research conducted in the 1960s during the last outbreak, oat (Avena sativa L.) is known to be one of the less favourable hosts to the saddle gall midge. Our study was performed in order to assess the host sensitivity of three oat varieties currently grown in Belgium: EVITA, EFFEKTIV and FREDDY. Therefore, oat varieties were sown on infested soil in two separate enclosures in a glasshouse. In the first enclosure, only the three oat varieties were grown; in the second one, these three oat varieties were grown together with two varieties of spring wheat: GRANNY and KWS CHAMSIN. Two parameters were measured: the percentage of leaves with laid eggs, and the number of galls per stem. The percentage of leaves with eggs showed that the infestation was significantly lower on oats when they were in presence of wheat. The egg infestation was also significantly higher on wheat than on oat, which means oat is a much less favourable host plant than spring wheat for egg laying. Oat varieties were significantly different from each other regarding the number of galls per stem, but with very little damage compared to wheat. The FREDDY variety even seemed to be completely resistant to saddle gall midge, as no galls were observed although there was a similar percentage of leaves with eggs for the three oat varieties. Cropping oat could thus contribute to reduce infestations of H. marginata. [less ▲]

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See detailThe general approach to the patient with osteoarthritis : is a treatment algorithm feasible ?
Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 385

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See detailDes ambassadeurs entre Liège et Bourgogne: Pour une étude des relations diplomatiques des pouvoirs liégeois avec les ducs Valois
Masson, Christophe ULg

in Publication du Centre Européen d'Etudes Bourguignonnes (2013), LIII(2013), 51-66

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See detailEvaluation de l'exposition professionnelle aux cytostatiques des travailleurs de deux services du CHU de Liège
Rusu, Dorina; DUBOIS, Nathalie ULg; Surleraux, Cécile et al

in Acta Clinica Belgica (2013), 68(6), 472

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women
Reginster, Jean-Yves ULg; Ellis, AG; Luo, X et al

in Osteoporosis International (2013), 24(1), 37

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See detailPharmacological management : osteoporosis and osteoarthritis, similarities and differences
Reginster, Jean-Yves ULg

in Osteoporosis International (2013), 24(1), 75-76

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See detailHow adaptation strategies of crops could counteract climate change effects? The case of four catchments in Wallonia, Belgium.
Bauwens, Alexandra ULg; Sohier, Catherine ULg; Degré, Aurore ULg

in Geophysical Research Abstracts (2013), 15

A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to significantly reduce crops’ yields under current agricultural practices ... [more ▼]

A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to significantly reduce crops’ yields under current agricultural practices. This contribution uses an agro-hydrological model in order to assess the potential effects of climate evolution on crop development, yield, and water balance for the main agricultural productions in the Meuse catchment. Erosion risk is also evaluated. We show that grasslands and maize yield decrease and yield variability increases under climate change scenarios. The leaf area index study permits to put in emphasis the earlier start of the vegetation due to warmer climate. It appears that all the sensitive stages occur earlier in the season and that crops are negatively affected by summer drought stress. The better understanding of crops development under evolving climate allows us to propose some changes in agricultural practices and to assess their effectiveness. We evaluate different strategies of adaptation in agricultural practices in order to reduce the potential negative effects of climate change on grasslands and maize production. Adaptation strategies proposed are advanced sowing and harvesting date, introduction of a cover crop for maize and advance in the cutting dates for grasslands. In the particular case of the Vesdre catchment, shifting the growth period of maize permits to avoid the water-deficit period and allow increased yield. This shift makes it possible to introduce a cover crop that will drastically reduce winter soil erosion. For grassland, the adjustment of the cutting dates favored the first cut and the earlier start of the vegetation. The second cut is less profitable due to summer drought stress. The vulnerability assessments focused on the main rotation encountered in the cultivated areas and in the difference in the cover type of these crops. [less ▲]

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See detailPhenomenology of $\alpha_s$ at intermediate energy: the quark-hadron duality approach
Courtoy, Aurore ULg

in PoS - Proceedings of Science (2013)

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See detailPatients' preferences for osteoporosis drug therapy : a discrete choice experiment
Hiligsmann, Mickaël ULg; Dellaert, B; Dirksen, C et al

in Osteoporosis International (2013), 24(1), 53

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See detailTime-Controlled Cryogenic Zone Compression (tCZC) GC-HRMS, A Novel Tool fro Targetted Analysis at Uktra Trace Level
Krumwiede, D; Mehmlann, H; Focant, Jean-François ULg et al

in Organohalogen Compounds (2013), 75

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See detailFirst steps towards an explicit modeling of aba production and translocation in relation with the water uptake dynamics
Lobet, Guillaume ULg; Pagès, Loic; Draye, Xavier

in Acta Horticulturae (2013), 991

Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act ... [more ▼]

Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act as a switch in the water flow, even under high transpiration demand. The control of the stomatal aperture by the plant has been the object of numerous research projects since decades and different models have been developed to study stomatal regulation. The plant hormone abscisic acid (ABA) produced in the leaves acts as an endogenous signal triggering stomatal closure, but is also thought to act as a long distance signal that is produced by roots experiencing water deficit. However, the relative contributions of leaf-supplied ABA, root-supplied ABA and xylem water potential in the regulation of water flow remains a matter of controversy. Using a novel functional structural plant model (PlaNet-Maize-ABA), we report here a first attempt to explicitly simulate ABA production, degradation, translocation in all plant organs and their effect on the transpiration flow. [less ▲]

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See detailSiblings and coming-out
Haxhe, Stéphanie ULg; D'Amore, Salvatore ULg

in Psychology, Community & Health (2013), 2(2), 162

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See detailInhibition of sclerostin with romosozumab in postmenopausal women with low BMD : phase 2 trial results
McClung, M; Grauer, A; Boonen, S et al

in Osteoporosis International (2013), 24(1), 38-39

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See detailOn differentially dissipative dynamical systems
Forni, Fulvio ULg; Sepulchre, Rodolphe ULg

in IFAC-PapersOnLine website. (2013)

Dissipativity is an essential concept of systems theory. The paper provides an extension of dissipativity, named differential dissipativity, by lifting storage functions and supply rates to the tangent ... [more ▼]

Dissipativity is an essential concept of systems theory. The paper provides an extension of dissipativity, named differential dissipativity, by lifting storage functions and supply rates to the tangent bundle. Differential dissipativity is connected to incremental stability in the same way as dissipativity is connected to stability. It leads to a natural formulation of differential passivity when restricting to quadratic supply rates. The paper also shows that the interconnection of differentially passive systems is differentially passive, and provides preliminary examples of differentially passive electrical systems. [less ▲]

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See detailValidation of analytical method for the determination in serum of psychotropic drugs commonly prescribed in Rwanda by HPLC-DAD
Hahirwa, Innocent; Charlier, Corinne ULg; DENOOZ, Raphael ULg et al

in Acta Clinica Belgica (2013), 68(6), 479

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See detailEstimation of the fascine efficiency in terms of runoff infiltration and sediments deposition
Degré, Aurore ULg; Pineux, Nathalie ULg; Cantreul, Vincent ULg et al

in Geophysical Research Abstracts (2013), 15

Runoff inundations and mudflows are more and more frequent phenomena. In 2011, Belgium had a lot of its municipalities affected by this problematic. Since then, mitigation measures are more and more set ... [more ▼]

Runoff inundations and mudflows are more and more frequent phenomena. In 2011, Belgium had a lot of its municipalities affected by this problematic. Since then, mitigation measures are more and more set up in agricultural watersheds. The fascines are one of these measures which allow to protect the public and private infrastructures and in the same way, which don’t reduce the famers productivity. They consist in branches faggots piled up between two rows of stakes. These linear constructions are mainly put in place across concentrated runoff axis in order to slow down the water and to filter the mud. Only few quantifications of their effectiveness (in terms of flow and concentration water reduction) exist and are however needed to better recommend these types of mitigation measures. Our experiment aims at measuring discharge and mud concentration reduction due to the fascines in a completely defined context. The tests were realised through fascines planted in field border. A watertight surface of 2,45m to 0,80m carries the water to the fascines. Three types of fascines were tested (willow wood fascine, straw fascine, straw compacted fascine), three different water flows were applied (0,5L/s, 3L/s and 6L/s) and three water concentration in dry soil (13g/L, 26g/L, 38g/L) were used. The different factor combinations were tested. The results show that we can expect a reduction of 60% of the flow for the biggest water flows (proportional efficiency with the water flow). The factor interaction study doesn’t allow to see a difference between the type. About the sediment water concentration, the filtration can reach 50%, the fascine with wood faggots showing a better efficiency. Finally, the difference between the fascine type show that straw fascine can support a biggest watershed (25 hectares) than the wood faggot fascine can (5-10 hectares) but during a smaller return period (one year against five years). [less ▲]

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See detailModeling of Dendritic Cell-based vaccination Immunotherapy using Artificial Neural Networks
Mehrian, Mohammad ULg; Arabameri, Abazar; Sedghi, Alireza et al

in Modeling of Dendritic Cell-based vaccination Immunotherapy using Artificial Neural Networks (2013)

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See detailExtension of the Liège Intra Nuclear Cascade model to light ion-induced collisions for medical and space applications
Leray, S.; Mancusi, D.; Kaitaniemi, P. et al

in Journal of Physics: Conference Series (2013), 420

Detailed reference viewed: 15 (7 ULg)