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See detailg-Mode Oscillations in Hot B Subdwarf Stars
Charpinet, Stéphane; Van Grootel, Valérie ULg; Fontaine, Gilles et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact ... [more ▼]

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact helium core burning stars can develop low amplitude oscillations with periods in the range ∼ 1 − 4 hours that correspond to low degree, mid to high order g-modes. These modes have the property to penetrate deep inside the star, down to the boundary of the central convective core. They are consequently particularly interesting as asteroseismic probes. Here we briefly review how the g-modes behave in sdB stars, focusing in particular on the seismic signatures coming from the core itself. We also briefly summarize the first seismic results obtained from space data in pioneering efforts to exploit the potential of long period sdB pulsators as deep probes of the core structure. [less ▲]

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See detailForward Physics of Hadronic Colliders
Ivanov, Igor ULg

in Physics of Particles and Nuclei Letters (2013, December), 10(7), 739750

These lectures were given at the Baikal Summer School on Physics of Elementary Particles and Astrophysics in July 2012. They can be viewed as a concise introduction to hadronic diffraction, to the physics ... [more ▼]

These lectures were given at the Baikal Summer School on Physics of Elementary Particles and Astrophysics in July 2012. They can be viewed as a concise introduction to hadronic diffraction, to the physics of the Pomeron and related topics. [less ▲]

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See detailWhite Dwarf Stars: A Brief Overview
Fontaine, Gilles; Brassard, Pierre; Charpinet, Stephane et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of ... [more ▼]

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of stellar evolution for the vast majority of stars and, as such, bear the signatures of past events (such as mass-loss, mixing phases, loss and redistribution of angular momentum, and thermonuclear burning) that are of essential importance in the evolution of stars in general. In addition, white dwarf stars represent ideal testbeds for our understanding of matter under extreme conditions, and work on their constitutive physics (neutrino production rates, conductive and radiative opacities, interior liquid and solid equations of state, partially ionized and partially degenerate envelope equations of state, diffusion coefficients, line broadening mechanisms) is still being actively pursued. Given a set of constitutive physics, cooling white dwarfs can be used advantageously as cosmochronometers. Moreover, the field has been blessed by the existence of four distinct families of pulsating white dwarfs, each mapping a different evolutionary phase, and this allows the application of the asteroseismological method to probe and test their internal structure and evolutionary state. [less ▲]

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See detailThe instability strip of ZZ Ceti white dwarfs and its extension to the extremely low mass pulsators
Van Grootel, Valérie ULg; Fontaine, Gilles; Brassard, Pierre et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection ... [more ▼]

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection in these stars. We report here a detailed stability survey over the whole ZZ Ceti regime, including the very low masses where three pulsators have recently been found. We computed to this aim 29 evolutionary sequences of DA models with various masses and chemical layering. These models are characterized by the so-called ML2/α=1.0 convective efficiency and take into account the important feedback effect of convection on the atmospheric structure. We pulsated these models with the Liege nonadiabatic pulsation code MAD, which is the only one to conveniently incorporate a full time-dependent convection treatment and, thus, provides the best available description of the blue edge of the instability strip. On the other hand, given the failure of all nonadiabatic codes to account properly for the red edge of the strip, including MAD, we tested the idea that the red edge is due to energy leakage through the atmosphere. Using this approach, we found that our theoretical ZZ Ceti instability strip accounts remarkably well for the boundaries of the empirical strip. [less ▲]

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See detailDONATION AFTER CIRCULATORY DEATH INCREASES THE CADAVERIC DONOR POOL
Le Dinh, H.; DE ROOVER, Arnaud ULg; SQUIFFLET, Jean-Paul ULg et al

in Transplant International (2013, December), 26(S2), 54-101

Background: There is a controversy on the possibility to increase the organ donor pool by donation-after-circulatory-death (DCD) and the possible decrease in donation-after-brain-death (DBD) by DCD ... [more ▼]

Background: There is a controversy on the possibility to increase the organ donor pool by donation-after-circulatory-death (DCD) and the possible decrease in donation-after-brain-death (DBD) by DCD programs. Our aim is to report the DCD experience at the University Hospital of Liege, Belgium, from 2002 through 2012, in a donor region of about 1 million inhabitants. Methods: The prospective organ donor and recipient databases were retrospectively reviewed. Results: 94 and 331 procurements were performed from controlled DCD and DBD donors in the time period, respectively. DCD donors contributed to 22.1% of the deceased donor (DD) organ procurement activity from Jan 2002 to Dec 2012, and up to one-third annually since 2009. DCD liver and kidneys contributed 23.7% and 24.2% of the DD liver and kidney transplantation activity, respectively. There was no decrease of the DBD procurement in the study period. In 2012, overall 54 DD were procured in the Liege region, reaching a high procurement activity.Conclusions: Controlled DCD donors are a valuable source of transplantable liver and kidney grafts, and in our experience do not adversely affect DBD organ procurement activity. [less ▲]

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See detailStimuli-responsive magnetic nanohybrids for triggered drug release and potential tumor treatment via hyperthermia
Liu, Ji ULg; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Controlled Release (2013, November 28), 172(1), 39

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See detailLarge Nc baryons and Regge trajectories
Matagne, Nicolas; Stancu, Floarea ULg

in Bled Workshops in Physics (2013, November), 14(1), 37-42

The mixed symmetric positive and negative parity baryons are described in a similar way in the $1/N_c$ expansion method of QCD by using a procedure where the permutation symmetry is incorporated exactly ... [more ▼]

The mixed symmetric positive and negative parity baryons are described in a similar way in the $1/N_c$ expansion method of QCD by using a procedure where the permutation symmetry is incorporated exactly. This allows to express the mass formula in terms of a small number of linearly independent operators. We show that the leading term follows a different Regge trajectory from that found for symmetric states, when plotted as a function of the band number $N$. [less ▲]

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See detailL’admissibilité de la preuve en droit civil et en droit pénal
Kefer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2013, November), (2), 195-229

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See detailVitamin D coverage among adults in Wallonia (Belgium): findings from the NESCaV study
Hoge, Axelle ULg; Donneau, Anne-Françoise ULg; Streel, Sylvie ULg et al

in European Journal of Public Health (2013, November), 23

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See detailPrevalence of cardiovascular risk factors in Wallonia (Belgium): results from the NESCaV study
Streel, Sylvie ULg; Donneau, Anne-Françoise ULg; Hoge, Axelle ULg et al

in European Journal of Public Health (2013, November)

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See detailA Search For 15NH2 Emission Lines In Comets
Rousselot, Philippe; Pirali, O.; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

The determination of nitrogen isotopic ratios in solar system objects is important for a good understanding of their origin. The measurements of [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio done so far in ... [more ▼]

The determination of nitrogen isotopic ratios in solar system objects is important for a good understanding of their origin. The measurements of [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio done so far in various solar system objects and molecules have revealed a great diversity (from 50 to 441), all of them, except Jupiter, being enriched in [SUB]15[/SUB]N compared to the protosolar nebula. Different explanations have been proposed to explain this enrichement. One of them suggests that these differences reflect the different interstellar N reservoirs from which N-bearing molecules are originating (Hily-Blant et al., 2013). These authors, from observations of H[SUB]13[/SUB]CN and HC[SUB]15[/SUB]N in two prestellar cores, suggest that the molecules carrying the nitrile- (-CN) functional group would be more enriched in [SUB]15[/SUB]N than the molecules carrying the amine (-NH) functional group. Comets are interesting targets to test this theory because they contain both HCN and NH[SUP]3[/SUP] molecules. So far the [SUB]14[/SUB]N/[SUB]15[/SUB]N ratio has only been measured in CN (Arpigny et al., 2003; Manfroid et al., 2009) and HCN (Bockelée-Morvan et al., 2005, 2008) in comets, leading for both species to [SUB]14[/SUB]N/[SUB]15[/SUB]N ≈ 150. Our work aimed at measuring the [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio in NH[SUP]2[/SUP], which comes from NH[SUP]3[/SUP]. We have determined accurately the wavelengths of [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines with the AILES beamline spectrometer at synchrotron SOLEIL by Fourier transform spectroscopy. The analysis of this spectrum has permitted to extract the [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines wavelengths and to search for [SUB]15[/SUB]NH[SUP]2[/SUP] cometary emission lines. Thanks to a collection of spectra of 12 different comets obtained from 2002 to 2011 with the UVES spectrometer at the VLT ESO 8-m telescope (Manfroid et al., 2009), it has been possible to search for [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines with a high sensitivity. We will present the results obtained from these data. Arpigny et al., Science, 301, 1522-1525, 2003 Bockelée-Morvan et al., in Comets II, ed. M. C. Festou, H. U. Keller, & H. A. Weaver (Tucson: Univ. Arizona Press), 391-423, 2005 Bockelée-Morvan et al., ApJ, 679, L49-L52, 2008 Hily-Blant et al., Icarus 223, 582-590, 2013 Manfroid et al., A&A, 503, 613-624, 2009 [less ▲]

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See detailDNA fingerprinting using Diversilab system for genotyping characterization of Microsporum audouinii and Trichophyton violaceum
SACHELI, Rosalie ULg; DIMO, Lauryl; GRAIDE, Hélène ULg et al

in Mycoses (2013, October 01), 56(Supplement S3), 99

Objectives: To investigate the epidemiological determinants responsible for the high number of anthropophilic dermatophytes received by the National Reference Center for Mycosis of Liege (NRCL) during the ... [more ▼]

Objectives: To investigate the epidemiological determinants responsible for the high number of anthropophilic dermatophytes received by the National Reference Center for Mycosis of Liege (NRCL) during the year 2012. To perform a genotypic characterization by the Diversilab® system focusing on the two main isolated species, Microsporum audouinii and Trichophyton violaceum. To present a preliminary study preceding the national survey launched in 2013. Methods: A total of 51 strains of M. audouinii (50 clinical + 1 reference (ref.) strains) and 15 strains of T. violaceum (14 clinical + 1 ref. strain) originating from different locations through Belgium were included in the study. The fungal strains were first cultivated on Malt agar, then sub-cultured in Sabouraud liquid medium (Fluka). The grown mycelium was processed for DNA extraction following recommendations of the manufacturer (Ultra Clean® DNA Microbial isolation kit, MoBio laboratories). Genotypic analysis was performed using the DiversiLab® system (BioMérieux) for DNA fingerprinting and analysis. Results: Regarding M. audouinii, four different genotypic groups of strains were separated. Group 1 includes 11 strains and is only found in the Liège surroundings. Group 2 includes only one strain with little differences compared to group 1 and collected from the Liège area. These two groups may be related to each other. Group 3 contains 36 strains and the reference strain. This genotype is distributed in different Belgium locations. The last group, group 4, contains only 3 isolates sharing low similarities in comparison with the 3 other groups. Concerning T. violaceum, 6 different genotypic groups with a mixed geographical distribution were determined. Group 1 includes 8 clinical isolates and the ref. strain. The other five isolates are all different and seem not to be related to each other. Conclusion: The automated typing DiversiLab® system proved to be an easy and efficient method to investigate the molecular epidemiology of dermatophytes infections. Preliminary results of the study show that, through Belgium, several groups of isolates co-exist for M. audouinii and T. violaceum providing evidence of genetic heterogeneity. This variation can be related to acquired mutations due to environmental adaptation. Further investigations are necessary to better understand the impact of this genotypic variation. [less ▲]

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See detailStudy of the Forbidden Oxygen Lines in Comets at Different Heliocentric and Nucleocentric Distances
Decock, Alice ULg; Rousselot, P.; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

Oxygen is an important element in the chemistry of the solar system objects given its abundance and its presence in many molecules including H2O 80% of cometary ices). The analysis of oxygen atoms in ... [more ▼]

Oxygen is an important element in the chemistry of the solar system objects given its abundance and its presence in many molecules including H2O 80% of cometary ices). The analysis of oxygen atoms in comets can provide information not only on the comets themselves but also on the solar system. These atoms have been analyzed using the 3 forbidden oxygen lines [OI] observed in emission in the optical region at 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the red lines) (Swings, 1962). Our analysis is based on a sample of 12 comets of various origins. The observing material is made of 53 high signal-to-noise spectra obtained with the high-resolution UVES spectrograph at the ESO VLT from 2002 to 2012 (Manfroid et al, 2009). After noticing that the green line is blended with one C2 line, we built synthetic spectra of C2 for each observing circumstances and we subtracted its contribution to the cometary spectra in order to ensure the decontamination of the 5577 Å line. Then, we measured the intensity of the 3 [OI] lines at different heliocentric distances. By comparing the green to red lines ratio (G/R) with the Bhardwaj & Raghuram (2012) effective excitation rates, we found that H2O is the main parent molecule when the comet is observed at 1 au. When the comet is located beyond 2.5 au from the Sun, CO2 also contributes to the production of oxygen. Studying forbidden oxygen lines could be a new way to estimate the abundances of CO2 in comets, a very difficult task from the ground (Decock et al. 2013). In order to estimate the effect of the quenching on our results, we analyzed the evolution of the G/R ratio at different nucleocentric distances. For nearby comets, we divided the extended 2D spectrum into several zones in order to analyze the oxygen lines as close as possible to the nucleus (down to ~10 km for the closest comets). Their analysis will allow us to study the link of the oxygen lines with the nucleocentric distance. We found a clear variation of the G/R ratio close to the comet nucleus that is in agreement with a contribution from CO2 as predicted by Raghuram & Bhardwaj (2013). [less ▲]

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See detailThe May 4, 2013 Stellar Occultation by Pluto and Implications for Pluto's Atmosphere
Olkin, Catherine B.; Young, L. A.; Borncamp, D. et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

On May 4 2013, Pluto passed in front of a 14 star and the shadow was well observed from multiple occultation groups. This paper presents results from the three light curves observed at Las Cumbres ... [more ▼]

On May 4 2013, Pluto passed in front of a 14 star and the shadow was well observed from multiple occultation groups. This paper presents results from the three light curves observed at Las Cumbres Observatory Global Telescope Network (LCOGT) from their Cerro Tololo site. The three LCOGT telescopes have 1.0 m apertures and used identical frame-transfer cameras. The cameras currently have a 2 second readout time therefore autonomous observations were scheduled with different exposure times to give good time resolution of the event. We will present results of this occultation and compare occultation results from 1988 to 2013 with volatile transport models. [less ▲]

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See detailHyper-volatiles in Comet C/2010 G2 (Hill)
Kawakita, Hideyo; Dello Russo, N.; Vervack, R. J. J. et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The ... [more ▼]

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The comet had been in outburst. Over the two nights of our observations, prominent emission lines of CH4 and C2H6 along with weaker emission lines of H2O, HCN, CH3OH and CO were detected. The gas production rate of CO was comparable to that of H2O. The mixing ratios of CO, HCN, CH4, C2H6, and CH3OH with respect to H2O are higher than those for normal comets by a factor of five or more. Hyper-volatile species such as CO and CH4 were enriched in the coma of comet Hill suggesting that the sublimation of these hyper-volatiles could sustain the outburst of the comet. Based on a comparison with optical observations, some fraction of water in the inner coma existed as icy grains. Those icy ice grains were likely ejected from nucleus by the sublimation of hyper-volatiles. [less ▲]

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See detailUne infiltration de plasma riche en plaquettes (PRP) pour traiter les tendinopathies rotuliennes supérieures chroniques
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1),

Objective: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

Objective: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. Infiltration of platelet-rich plasma (PRP) could be a new therapy for such chronic tendinopathies. Materiel and methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10-point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. Results: Pain during daily activities significantly decreased with time (especially after 6 weeks and continued to a lesser extend up to 3 months). During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. Discussion: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol is efficient to improve symptoms of chronic jumper’s knee in patients non-responsive to classical conservative treatments. [less ▲]

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See detailCoexistence entre adénom hypophysaire et phéochromocytome - présentation de cas
Rostomyan, Liliya ULg; Potorac, Iulia ULg; Filipponi, S et al

in Annales d'Endocrinologie (2013, October), 74

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See detailPratique des actes préventifs : ce qui détermine l'attitude des médecins généralistes belges
Vanmeerbeek, Marc ULg

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2013, October), 61(octobre), 309

En Belgique, l’implémentation des procédures préventives reste insuffisante dans plusieurs domaines, avec un gradient socio-économique défavorable aux moins nantis. Une implication accrue des médecins ... [more ▼]

En Belgique, l’implémentation des procédures préventives reste insuffisante dans plusieurs domaines, avec un gradient socio-économique défavorable aux moins nantis. Une implication accrue des médecins généralistes pourrait améliorer ces deux aspects, grâce à leur proximité avec les bénéficiaires potentiels. L’opinion des généralistes belges sur un investissement accru en prévention a été évaluée au moyen d’une échelle d’attitude construite au départ de verbatims provenant d’une enquête qualitative préalable. L’échelle a exploré 5 axes : vision globale de la santé, gestion collective des patients, évaluation de processus, collaboration et santé publique. Un questionnaire postal a été envoyé à 2.500 généralistes, dont 457 ont répondu valablement. L’axe gestion collective a obtenu la moyenne des scores d’attitude favorable à la prévention la plus élevée (77%), devant les axes santé globale (76%), évaluation (72%), collaboration (69%) et santé publique (63%). L’analyse factorielle a révélé deux facteurs principaux, l’organisation de la pratique (62% de la variance) et la formalisation (14% de la variance). L’organisation de la pratique (gestion des échéances, des données, pro-activité, sentiment de responsabilité envers la patientèle) était le facteur principal et était lié surtout aux associations et groupes pluridisciplinaires. La formalisation (codification précise de la pratique, assortie ou non d’une évaluation) venait ensuite et expliquait les plus fortes différences entre praticiens et entre communautés linguistiques. Les meilleurs scores étaient liés à une moindre ancienneté (<20 ans de pratique), aux associations et à la pratique urbaine. Le sexe du médecin ou le fait de travailler dans une structure préventive comme la protection maternelle et infantile étaient sans effet significatif. L’organisation de la prévention dépend des gouvernements de Flandre et de Wallonie-Bruxelles, mais des facteurs personnels et organisationnels propres aux généralistes doivent être considérés pour expliquer les résultats actuels. Une diffusion plus large et équitable des actes préventifs passe par la prise en compte de ces facteurs. [less ▲]

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See detailActualités thérapeutiques dans la prise en charge des tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1), 050-003

“Conventional” treatments of tendinopathies are generally employed empirically to fight pain and inflammation but they do not modify the histological structure of the tendon. However, these treatments are ... [more ▼]

“Conventional” treatments of tendinopathies are generally employed empirically to fight pain and inflammation but they do not modify the histological structure of the tendon. However, these treatments are not completely satisfactory and the recurrence of symptoms is common. In contrast to the passive pattern of many therapies dedicated to tendon disorders, some authors have promoted an eccentric training mode. Such active eccentric training programs are aimed at thwarting an aetiopathogenic theory proposing insufficient tensile strength of the tendon exposed to external loads which could progressively damage it. Though the literature remains incomplete on tendon architecture remodelling and real histological adaptations following an adapted eccentric training, clinical results following such therapy appear promising. Due to its noninvasiveness, low complication rate and high applicability combined with good results, extracorporeal shock wave therapy has become a well known option within the therapeutic spectrum for many tendinopathies. More specifically, it has been successfully applied in chronic tendinopathy resistant to a conservative training program including eccentric exercises. Platelets release different cytokines and growth factors that could promote angiogenesis, tissue remodelling (bone, skin etc.), and wound healing. Platelet-rich plasma (PRP) is obtained by centrifuging autologous blood to have a high concentration of platelets depending on the isolation method. For this reason, different PRP preparation techniques cannot provide a consistently identical final product, but there is currently no international consensus on this issue. Despite the proven efficacy of PRP tissue regeneration in labs, there is currently little tangible clinical evidence for chronic tendon disorders. The few studies that have been performed appear unlikely to be comparable. Up to now, randomised controlled studies with appropriate placebo groups are needed to determine the real effectiveness of PRP for treating chronic tendon conditions. However, this therapeutic option remains very popular in sports, and many top athletes are using it in case of musculoskeletal conditions. What is more, it has been removed from the doping lost of the World AntiDoping Agency. Other new therapeutic options (infiltrations of polidocanol, hyaluronic acid, botulinum toxin, patches of derivatives Nitro...) for treating tendinopathies are also discussed in this review. [less ▲]

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See detailRéaction inflammatoire exubérante comme effet secondaire d’une infiltration de PRP
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; LEONARD, Philippe ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1), 068

Introduction : Infiltrations of plasma rich platelets (PRP) represent a new treatment of tendinopathies. Currently, no side effects were reported in this indication. Case report: We report the case of a ... [more ▼]

Introduction : Infiltrations of plasma rich platelets (PRP) represent a new treatment of tendinopathies. Currently, no side effects were reported in this indication. Case report: We report the case of a 35-year-old type 1 diabetic patient with right upper patellar tendinopathy that had persisted for more than 6 months. The patient benefited from an intratendinous infiltration of 6 mL of PRP (8.105 platelets/mm3, almost no red or white blood cells) after a carefully disinfection but without local anesthesia. Typically, a standardized program of sub-maximal eccentric rehabilitation should be started 1 week after infiltration. However, the patient experienced local swelling with erythema, increased heating and pain, which appeared just underneath the patella, without biological inflammatory syndrome. In absence of septic general symptoms, no blood or wound culture were made. At 2 weeks post-infiltration, a greatly increased Doppler signal in a thicker tendon was observed by ultrasounds compared to that before infiltration, but there was no sign of infection demonstrated by either MRI or CT. However, the local inflammation did not decrease after a 3-week treatment of local cryotherapy, local and oral NSAID, and adjunct use of colchicine 1 mg. Thus, an insidious infection was suspected, even though there was no evidence of biological inflammatory syndrome or sign of infectious lesion on imagery examination. Antibiotic therapy (rifampicine 600 mg + minocycline 100 mg), was initiated for three months. Due to a lack of improvement via imaging and clinical examination, a 3-phase bone scintigraphy was performed. The results suggested the presence of a complex regional pain syndrome type 1. The patient benefited from classical physical therapy and concomitant pain killers. The evolution was favorable after 6 months of treatment. Discussion : Even though PRP infiltration represents a new and promising treatment for tendinopathy, more studies are needed both to verify its clinical efficacy. Moreover, implementing this innovative treatment requires caution because of potential adverse events. Thus, the balance between benefits and risks must be carefully evaluated before using this treatment, especially in patients with type 1 diabetes. [less ▲]

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See detailElaboration de critères pour l'évaluation de "l'agir" du plan national nutrition santé en Belgique
Absil, Gaetan ULg; Schippers, Nathalie ULg; Vandoorne, Chantal ULg

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2013, October), 61(4), 304

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See detailEvaluation de l’implantation de la vaccination contre le papillomavirus dans les pratiques des services de santé scolaire en Fédération Wallonie Bruxelles
Miermans, Marie-Christine ULg; Swennen, Béatrice; Vermeeren, Axelle

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2013, October), 61(Supplément 4), 233

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See detailUne néoplasie endocrinienne multiple particulière
Boccar, S; VROONEN, Laurent ULg; HAMOIR, Etienne ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailGerminome intracrânien bifocal : la biopsie est-elle toujours indispensable?
KREUTZ, Julie ULg; BONNEVILLE, Jean-François ULg; Potorac, Iulia ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailFIPA : étude clinique et génétique à l'Hôpital "King Edward Memorial", Bombay (Mumbai) Inde
Bothra, N; Daly, Adrian ULg; CASTERMANS, Emilie ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailHypothyroïdie infraclinique non auto-immune et statut iodé : étude prospective d'intervention
VALDES SOCIN, Hernan Gonzalo ULg; Tudorescu, A; Lutteri, L et al

in Annales d'Endocrinologie (2013, October), 74

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See detailInvestigation olfactive de la mort
Focant, Jean-François ULg; Stefanuto, Pierre-Hugues ULg; Brasseur, Catherine ULg et al

in Acta Clinica Belgica (2013, October), 68-6

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See detailLe PPNAD, une cause rare de syndrome de Cushing
PETIGNOT, Sandrine ULg; VROONEN, Laurent ULg; HAMOIR, Etienne ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailStrength improvement after 3months of resistance training among Parkinson's disease patients
Demonceau, Marie ULg; rodriguez de la cruz, carlos; NAVEAU, Florence ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(s1), 196

Objectives.– To assess the feasibility and the effects of a strengthening program for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn and Yahr stage [1] < III of PD were ... [more ▼]

Objectives.– To assess the feasibility and the effects of a strengthening program for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn and Yahr stage [1] < III of PD were allocated to either 24 sessions of strength training (ST group; n = 8) or to a control group (C group; n = 6) for 3 months. Concentric knee muscle strength and a maximal cycling incremental test were performed at baseline and after training. Training consisted of progressive resistive exercises on leg press, leg extension, leg curl, between 50 and 80% of 1RM and was completed by non-instrumented exercises for trunk and upper limbs muscles. Anxiety, depression and quality of life were assessed using questionnaires. An Anova for repeated measures was used for statistical analysis. Results.– Six patients of the ST group (75%) fully completed the program. There were significant “group by time” effects for all knee muscles strength measures of less involved side (P < 0.05). A significant “group by time” effect was also found for knee flexors of the most involved side, but only at angular speed of 180°/s (P = 0.03). Patients of ST group also increased maximal aerobic power (+13%) whereas patients of C group decreased their performances (–9%; “group by time” effect, P = 0.04). No changes in anxiety, depression or quality of life could be highlighted. Conclusions.– The increase of some strength measures in ST group showed that progressive strength training counteracts strength decrease among people with Parkinson's disease. Strengthening also had a positive effect on maximal aerobic power. [less ▲]

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See detailLe gigantisme : Les résultats d'une étude clinique et génétique internationale
Rostomyan, Liliya ULg; Daly, Adrian ULg; Lila, A et al

in Annales d'Endocrinologie (2013, October), 74

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See detailLe carcinome parathyroïdien familial : une forme agressive d'hyperparathyroïdie primaire
Tudorescu, A; VROONEN, Laurent ULg; BETEA, Daniela ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailCorrélations significatives de l'aspect en IRM haute résolution des adénomes hypophysairesà GH avant traitement
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Schillo, F et al

in Annales d'Endocrinologie (2013, October), 74

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See detailReceptor expression in craniopharyngiomas causing tumor growth in pregnancy : case report and review of the literature
Tome, M; VROONEN, Laurent ULg; THIRY, Albert ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailTRAPPIST (TRAnsiting Planets and PlanetesImals Small Telescope)
Jehin, Emmanuel ULg; Gillon, Michaël ULg; Opitom, Cyrielle ULg et al

in EPSC Abstract 2013 (2013, September 13), 8

TRAPPIST is a 60-cm robotic telescope that has been installed in June 2010 at the ESO La Silla Observatory [1]. Operated from Liège (Belgium) it is devoted to the detection and characterisation of ... [more ▼]

TRAPPIST is a 60-cm robotic telescope that has been installed in June 2010 at the ESO La Silla Observatory [1]. Operated from Liège (Belgium) it is devoted to the detection and characterisation of exoplanets and to the study of comets and other small bodies in the Solar System. We describe here the hardware and the goals of the project and give an overview of the comet production rates monitoring after three years of operations. [less ▲]

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See detailStudy of the forbidden oxygen lines in comets at different heliocentric and nucleocentric distances
Decock, Alice ULg; Jehin, Emmanuel ULg; Rousselot, Philippe et al

in EPSC Abstract 2013 (2013, September 12), 8

Oxygen is an important element in the chemistry of the Solar System objects given its abundance and its presence in many molecules including H2O, which constitutes 80% of cometary ices. The analysis of ... [more ▼]

Oxygen is an important element in the chemistry of the Solar System objects given its abundance and its presence in many molecules including H2O, which constitutes 80% of cometary ices. The analysis of oxygen atoms in comets can provide information not only on the comets themselves but also on our Solar System. These atoms have been analyzed using the three forbidden oxygen lines [OI] observed in emission in the optical region at 5577 Å (the green line), 6300 Å and 6364 Å (the red lines) [1]. These lines are difficult to analyze because their detection requires high spectral and spatial resolutions. The oxygen analysis is interesting because it allows the determination of its parent molecules. [less ▲]

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See detailTRAPPIST monitoring of comet C/2012 F6 (Lemmon)
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in EPSC Abstract 2013 (2013, September 12), 8

Comet C/2012 F6 is a long-period comet that reached perihelion on March 23, 2012. The unexpected brightness of this comet since December 2012 allowed us to obtain narrowband photometry and to study its ... [more ▼]

Comet C/2012 F6 is a long-period comet that reached perihelion on March 23, 2012. The unexpected brightness of this comet since December 2012 allowed us to obtain narrowband photometry and to study its chemical composition as well as its rotation. [less ▲]

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See detailCould bonobos, Pan paniscus, influence forest re(colonization) in a forest-savana mosaic?
Trolliet, Franck ULg; Serckx, Adeline ULg; Huynen, Marie-Claude ULg et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, September 12)

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See detail"Product-oriented engineering" applied to the development of porous scaffolds for tissue engineering.
de Bien, Charlotte ULg; Ounally, Thameur ULg; Collard, Valérie ULg et al

in Procedia Engineering (2013, September 02)

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D ... [more ▼]

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D microstructure was characterized by X-ray microtomography and related to the operating conditions used. Two types of scaffold end-use properties were characterized in relation to their microstructure: the mechanical and the transport properties. Scaffold young's modulus was computed from data measured on tension-compression devices. To evaluate the permeability, Darcy’s experiments were carried out. The obtained results allowed highlighting the quantitative relationships existing between elaboration conditions, microstructure and end use properties of the fabricated PLA scaffolds. [less ▲]

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See detailEvaluation of Everolimus (EVE) in HER2+ advanced breast cancer (BC) with activated PI3K/mTOR pathway : exploratory biomarker observations from the BOLERO-3 trial
JERUSALEM, Guy ULg; ANDRE, Fabrice; CHEN, David et al

in European Journal of Cancer (2013, September), 49(Supplement 3), 8

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See detailHazard factors of ACL rupture: Neuromuscular factors
Kaux, Jean-François ULg; Delvaux, François ULg; MASSART, Nicolas ULg et al

in European Journal of Sports Medicine (2013, September), 1(supplement 1), 50-51

Injuries to the anterior cruciate ligament (ACL) of the knee are disabling, often associated with other intra-articular damages and increase the risk of early onset of osteoarthritis. It is very probable ... [more ▼]

Injuries to the anterior cruciate ligament (ACL) of the knee are disabling, often associated with other intra-articular damages and increase the risk of early onset of osteoarthritis. It is very probable that multiple risk factors act in combination to influence injury risk. It is important to have a comprehensive understanding of these ACL risk factors, whose neuromuscular factors, even if investigations on neuromuscular factors reported to date do not provide a complete understanding of ACL injury risk. According to several recent studies, the neuromuscular control of joint biomechanics during a specific activity seems to represent a predicting factor of an ACL injury, by quantifying the intersegmental forces and moments generated about the tibio-femoral joint. Laboratory studies have shown that landing from a jump performs cutting and pivoting maneuvers with less knee and hip flexion, increases knee valgus and internal rotation of the hip coupled, with increased external rotation of the tibia and quadriceps muscle activation (especially in women). It has been hypothesized that these movement patterns increase the strain in the ACL during activity and that the large difference in knee injury incidence rates between males and females (1/4.5) may be attributed to neuromuscular differences and resultant mechanics. Although studies have shown that the position of the knee and the magnitude and sequence of muscle contraction can increase ACL strain values, it is hard to exactly correlate these movements to what occurs during activity and sport and at the time of ACL injury. Recently, a simpler assessment tool has been validated and is able to be administered in a clinic-based testing environment Consequently, the screening for ACL injury risk could be performed on a more widespread population. Athletes who went on to a primary ACL injury also demonstrated significant side to side differences in lower extremity biomechanics as well as reduced relative lower extremity flexor activation relative to an uninjured control population during the vertical drop jump. Similar mechanisms of injury risk have been identified in athletes medically cleared to return to sport after ACL reconstruction. These seminal findings indicate that these abnormal and asymmetrical biomechanical and neuromuscular control profiles are likely both residual to, and exacerbated by, the initial injury. A study revealed that a fatigue-induced protocol altered the latency as well as the magnitude of reflex responses of the hamstring muscles and the tibial translation only in women. The authors of various studies have suggested that the hamstring muscles play an important role in maintaining knee stability and that they protect the ACL during movements of the tibia relative to the femur. Therefore, decreased reflex responses of the hamstring muscles and in turn an increased the tibial translation might contribute to the pathomechanics of the ACL injuries. It is therefore conceivable that the fatigue-induced decrease of the hamstring neuromuscular function may increase the tibial translation and probably contributes to the higher incidence of ACL injuries, especially in women. A preventive approach to decrease ACL injuries could integrate muscle imbalances as a risk factor. If it has been scientifically validated than the muscle strength profile determined by an isokinetic testing offers a predictive value on the hamstring lesion occurrence, similar studies have not permitted such a conclusion about ACL injury. The isokinetic assessments after ACL reconstruction have allowed us to observe, on the healthy contralateral knee, a higher frequency of reduced hamstring/quadriceps ratios. A possible pre-existing weakness in the hamstring and the occurrence of an ACL injury is therefore possible but only a difficult prospective approach due to the multifactorial nature of ligament injuries could clarify that point. In conclusion, a functional analysis of the landing of a jump and an isokinetic muscle strength assessment have been suggested to represent predictive elements of an ACL rupture, but further studies are needed to have a stronger evidence of their predictive qualities of injury. [less ▲]

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See detailImpacts of WLG on the regeneration of logged forests: preliminary insights in a Gabonese logging concession
Haurez, Barbara ULg; Petre, Charles-Albert ULg; Doucet, Jean-Louis ULg

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, September), 84(3-5), 284-285

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See detailCritères de retour sur le terrain après plastie LCA chez le footballeur professionnel
Croisier, Jean-Louis ULg; Rochcongar, Pierre; Bruyère, Olivier ULg et al

in European Journal of Sports Medicine (2013, September), 1(1),

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See detailHypercalcémie réfractaire et sécrétion ectopique de calcitonine dans un cancer neuroendocrine du pancréas : Effets hypocalcémiants du Cinacalcet
VALDES SOCIN, Hernan Gonzalo ULg; LOLY, Jean-Philippe ULg; BETEA, Daniela ULg et al

in Annales d'Endocrinologie (2013, September), 74(4), 235-462

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

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See detailEffect of the lengthening of the protocol on the reliability of knee muscle fatigue indicators
Bosquet, L.; Maquet, Didier ULg; Forthomme, Bénédicte ULg et al

in European Journal of Sports Medicine (2013, September), 1(1), 150

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See detailIs 5-Hydroxytryptamine (serotonin) involved in the pathogenesis of idiopathic pulmonary fibrosis in dogs ?
Krafft, Emilie ULg; Roels, Elodie ULg; Laurila et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailPhysiological interpretation of the slope during an isokinetic fatigue test of the knee
Bosquet, L.; Gouadec, K.; Berryman, N. et al

in European Journal of Sports Medicine (2013, September), 1(1), 151

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See detailRéaction inflammatoire exubérante suite à une infiltration de PRP
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; LEONARD, Philippe ULg et al

in European Journal of Sports Medicine (2013, September), 1(Supplement 1), 278-279

Background: PRP, obtained from centrifuged autologous blood, contains a large quantity of growth factors, which may enhance the tissue healing processes. Local infiltration of PRP represents a relatively ... [more ▼]

Background: PRP, obtained from centrifuged autologous blood, contains a large quantity of growth factors, which may enhance the tissue healing processes. Local infiltration of PRP represents a relatively new treatment for tendinopathies. To date, no side effects have been reported after infiltration of PRP to treat tendinopathy. Case report: A 35-year-old patient had a right upper patellar tendinopathy which was resistant to all conservative treatments for more than 6 months. The patient was a type 1 diabetic (well controlled). He had an intratendinous infiltration of 6 mL of PRP (8.105 platelets/mm3, almost no red or white blood cells) after disinfection but without local anaesthetic. Immediately following the infiltration, local cryotherapy was performed for 15 minutes. NSAIDs were avoided, but class-1 or -2 pain-killers were authorised if necessary. A standardised sub-maximal eccentric rehabilitation should have been started 1 week after. However, the patient experienced local swelling with erythema, increased heating and pain which appeared just underneath the patella, but without biological inflammatory syndrome. A great Doppler signal in a thicker patellar tendon was observed by US, but there was no sign of local infectious disease demonstrated by either CT or MRI. However, the local inflammation did not decrease after a progressive 3-week treatment of local cryotherapy, local and oral NSAIDs and colchicine 1 mg. Thus, an insidious infection was suspected, even though there was neither evidence of biological inflammatory syndrome nor sign of infectious lesion on imagery examination. An antibiotic therapy (rifampicine 600 mg + minocycline 100 mg) was initiated for 3 months. Finally, a 3-phase bone scintigraphy suggested the presence of a complex regional pain syndrome type 1 treated by a classical physical therapy and concomitant class-2 pain killers. The evolution was favourable after 6 months of symptomatic treatment, and the pain decreased to a level similar to that before the infiltration of PRP. Discussion/Conclusions: This case report draws attention to potential side effects that are linked to this new therapy by infiltration of platelet rich plasma in case of tendinopathy, in particular when used in patients with type 1 diabetes. Thus, the balance between benefits and risks must be carefully evaluated before using this treatment in patients with type 1 diabetes. [less ▲]

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See detailA case of Longitudinal Vaginal Septum in a mare
Parrilla Hernandez, Sonia ULg; Ponthier, Jérôme ULg; Deleuze, Stefan ULg

in Reproduction in Domestic Animals (2013, September), 48(suppl1), 112-113

LVS occurs when there is failure in the fusion of müllerian ducts or in the regression of the vaginal septum. Primary or secondary cause of infertility, increases the risk of dystocia or alter sport ... [more ▼]

LVS occurs when there is failure in the fusion of müllerian ducts or in the regression of the vaginal septum. Primary or secondary cause of infertility, increases the risk of dystocia or alter sport performance. It is most likely under-diagnosed as it is often asymptomatic and an incidental finding. [less ▲]

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See detailInfluence of game playing on the muscular profile of shoulder rotators of handball players
Ucay, O.; Gasq, D.; Forthomme, Bénédicte ULg et al

in European Journal of Sports Medicine (2013, September), 1(1), 105

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See detailLes effets d'une supplémentation en vitamine D sur la force musculaire : une méta-analyse d'essais randomisés contrôlés
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Rabenda, Véronique ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 38

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See detailShoulder and handball
Gleizes Cervera, S.; Croisier, Jean-Louis ULg; Kaux, Jean-François ULg et al

in European Journal of Sports Medicine (2013, September), 1(1),

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See detailRunning races: study of the stress and cardiac biomarkers
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; MELON, Pierre ULg et al

in European Journal of Sports Medicine (2013, September), 1(Supplement 1), 212

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured ... [more ▼]

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured by new commercially available high-sensitive methods in subjects undergoing a marathon and an ultra-trail. Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Materials and Methods: Twenty eight subjects (26 men, 42.5 ± 11 yo) ran the Maasmarathon (42.195 kilometers) between Visé (Belgium) and Maastricht (The Netherlands) and 33 subjects (33 men, 45.7±9.3yo) ran the Ultratour of Liège (Belgium ; 67 km). We took blood sample before (T0), just after (T1) and 3 hours after the race (T3). In all the patients, cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. The protocol was approved by the Ethics Committee of the University of Liège (Belgium). All subjects gave their informed consent. All statistical analyses were performed using Medcalc version 8.1 for Windows. p-value <0.01 was regarded as statistically significant. Results and discussion: A significant difference between hsTnT concentrations at T0 and T1 (p<0.0001), and between T0 and T3 (p<0.001) for NT-proBNP have been observed, but not between T1 and T3. This observation appeared only after a strenuous exercise. However, up to now this type of exercise is not reproducible easily in a laboratory. Moreover, nobody knows if these observations would have cardiac consequences at long terms. Conclusions: Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death. [less ▲]

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See detailImmunohistochemical transforming growth factor Beta1 and its activation, storage and signalling pathways in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailImportance du déficit en vitamine D chez les femmes françaises ostéoporotiques et ostéopéniques âgées de plus de 80 ans
Bruyère, Olivier ULg; Slomian, Justine ULg; Beaudart, Charlotte ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 75

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See detailIMMUNOHISTOCHEMICAL ANALYSIS OF TRANSFORMING GROWTH FACTOR BETA 1 AND ITS SIGNALLING PATHWAYS IN CANINE IDIOPATHIC PULMONARY FIBROSIS
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailCaractéristiques cliniques des sujets répondeurs à la vibrotonie corporelle totale
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Maquet, Didier ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 118-119

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See detailPyovagina caused by pyometra and a persistent hymen in a 9-year-old bitch
Van Den Berghe, Femke ULg; Ponthier, Jérôme ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (2013, September), 48(suppl1), 114

Pyovagina with a persistent hymen is very uncommon in a 9-year-old intact bitch. Blood discharge during prooestrus phases of previous cycles and the recent purulent vulvar discharge indicate an -at least ... [more ▼]

Pyovagina with a persistent hymen is very uncommon in a 9-year-old intact bitch. Blood discharge during prooestrus phases of previous cycles and the recent purulent vulvar discharge indicate an -at least partially- perforated hymen. For an unknown cause the hymen must have re-sealed after uterine contamination explaining a pyovagina that was bulging in the perineal area [less ▲]

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See detailIntérêt des ondes de choc dans le traitement des fasciites plantaires
Fromm, Aurélien; Vanderthommen, Marc ULg; LAURENT, Jean-Marie ULg et al

in European Journal of Sports Medicine (2013, September), 1(Supplement 1), 276-277

Introduction : Over the past ten years, radial shock wave therapy usage has grown tremendously. Prescribed for chronic tendinopathy, its real benefit has yet to be demonstrated. Objective : Demonstrate ... [more ▼]

Introduction : Over the past ten years, radial shock wave therapy usage has grown tremendously. Prescribed for chronic tendinopathy, its real benefit has yet to be demonstrated. Objective : Demonstrate radial shock wave therapy benefits in plantar fasciitis treatment. Materials and methods : Our experimentation is a study over twelve weeks divided in 2 periods: the control phase (week 0 to week 6) and treatment phase (week 6 to week 11). It includes 3 evaluations (T1, T2 and T3) respectively at 0, 6 and 11 weeks. A standard evaluation consists of one VAS pain, an algo-functional backwash survey about the ankle (modified FFI), algometer test and dynamic analysis of the foot on strength platform. The radial shock wave therapy has been performed thanks to Swiss DolorClast machine (Electro Medical Systems) Results : Statistical analysis show radial shock wave therapy induces a highly significant improvement (p<0,0001) on EVA results (50%), ankle algo-functional backwash (62.6%) and pain sensitivity threshold (49.6%). Therefore, a significant correlation can be observed during T2- T3 period between pain sensitivity threshold improvement and patients age (p=0,012). The statistical results show a time increase trend for foot-ground contact over time. It is not significant though. Conclusion : The use of radial shock wave therapy in plantar fasciitis treatment helps decrease pain and improve step. However, additional studies performed on bigger samples have to be completed to confirm these results. [less ▲]

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See detailInfluence of concentration on equine fresh semen conservation
Ponthier, Jérôme ULg; Bloomaert, Didier; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (2013, September), 48(suppl1), 85

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See detailComparison of four cartridge type automated blood gas analysers for arterial blood gas analysis in dogs
Roels, Elodie ULg; Delvaux, François ULg; Farnir, Frédéric ULg et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailIs the CXC-Chemokine CXCL8 involved in the breed predisposition of west highland white terrier to canine idiopathic pulmonary fibrosis ?
Roels, Elodie ULg; Krafft, Emilie ULg; Laurila, HP et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailGP’s engagement in detecting and managing abuse of alcohol, illegal drugs, hypnotics and tranquilizers in the Belgian adult population
Ketterer, Frédéric ULg; Lambrechts, Marie-Claire; Symons, Linda et al

in European Journal of General Practice (2013, September), 19(3), 162-184

Background General practitioners (GPs) Occupational physicians (OPs) can play an important role in detecting and managing substance abuse in the working population. The UP TO DATE project aims at ... [more ▼]

Background General practitioners (GPs) Occupational physicians (OPs) can play an important role in detecting and managing substance abuse in the working population. The UP TO DATE project aims at identifying the difficulties these professionals encounter in this area, and to explore ways of collaboration in providing appropriate care. Research question What are the experiences, attitudes and decision making of GPs and OPs regarding to alcohol, illegal drugs, hypnotics and tranquilizers abuse from a physician’s perspective? Method In this qualitative study, with a phenomenological perspective, 20 GPs and 16 OPs, experienced with substance abuse in daily practice, got a face to face in-depth interview. (October until December 2012). Along with the data collection process the analysis started with a constant comparison between the data and the chosen integrated model of change (De Vries), using coding techniques of grounded theory. Results GPs meet important barriers to detect misuse of all substances. To address this issue and the patient’s motivation for change, the doctor-patient relationship is crucial. The risk to disturb the relationship, and loose the patient’s trust, is a major concern. An attitude of patient-centeredness, collaboration and empowerment of the patient is needed to make any progress, to get results and to overcome as a GP the burden of those demanding encounters. Self-care is an important concern. Collaboration with specialised health providers confronted GPs with various problems: not enough services, long waiting lists, unclear methods and criteria. GPs lack an insight in the OP’s role, and experience problems to contact them. Whether the OP is a trustful health advocate for their patient is a major concern. Some OPs are perceived too linked to the employer, raising legitimate concerns about professional confidentiality. Conclusion These are preliminary results. At the conference, a comprehensive overview on the qualitative analysis will be given. [less ▲]

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See detailPrimate Behaviour and Parasite Transmission in the Ecuadorian Amazon
Martin, Sarah ULg; Carrillo Bilbao, Gabriel Alberto; Bernstein, Sophie et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, August 10), 84(3-5), 135-346

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See detailA Methodology for The Appropriation And The Isolation of Nodal Diameter Modes in Cyclic Symmetric Structures
Nyssen, Florence ULg; Viguié, Régis; Simon, Daniel et al

in Proceedings of ASME 2013 International Design Engineering Technical Conference & Computers and Information in Engineering Conference IDETC/CIE 2013 (2013, August)

This paper presents a methodology enabling the appropriation and the isolation of a chosen nodal diameter modes in cyclic symmetric structures. In particular, a study about the minimum number and the ... [more ▼]

This paper presents a methodology enabling the appropriation and the isolation of a chosen nodal diameter modes in cyclic symmetric structures. In particular, a study about the minimum number and the optimized location of the excitation sources required in laboratory conditions to isolate a specific nodal diameter mode is conducted. This work includes a theoretical approach based on energy concepts. It is followed by the numerical and experimental validations on a stator stage of an axial compressor. The concept of modal appropriation is investigated here as the first step of the calibration procedure before engine tests. [less ▲]

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See detailDirect use of MACE EBV in the Walloon single-step Bayesian genomic evaluation system
Vandenplas, Jérémie ULg; Colinet, Frédéric ULg; Faux, Pierre ULg et al

in Journal of Dairy Science (2013, July), 96(E-Supplement),

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See detailPlatelet-rich plasma (PRP) to treat chronic upper patellar tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in British Journal of Sports Medicine (2013, July), 47(10 (e3)), 15

Background: Upper patellar tendinopathies remain often chronic and rebel to a thorough conservative treatment. Moreover, the option of a surgical treatment could be disappointing. New treatments are being ... [more ▼]

Background: Upper patellar tendinopathies remain often chronic and rebel to a thorough conservative treatment. Moreover, the option of a surgical treatment could be disappointing. New treatments are being developed. Injection of PRP is one of these. Platelets contain lot of growth factors which would have the potentiality to enhance the healing process of tendons. Even if in vitro and animal experiments have demonstrated this stimulation of tendon healing process1, clinical series are subject to controversy2. Methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments [VAS, clinical examination with an algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and Optojump) and imagery (ultrasounds and MRI)]were made before infiltration of PRP, and 6 weeks and 3 months after. The PRP was obtained by an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a 6-week standardised sub-maximal eccentric reeducation. Results: We observed a very significant improvement of the algofunctional status as soon as 6 weeks after the infiltration of PRP, and continued to a lesser extent up to 3 months. During functional evaluation, pain decreased as well, but without significant improvement of performances. No significant improvements in the imagery were observed. Interestingly, patients who had a VAS equal or below 1 after 3 months post-infiltration were younger (24.7 vs 32.2 y.o.). Moreover, these younger patients had a significant increase of the IKDC score (p=0.003), a significant improvement of pain during isokinetic evaluations (p<0.05), and during Optojump assessments (p=0.01). Seventy-five percent of subjects were able to return to sport, even if only half of these patients recovered the same level than before the tendinopathy. Discussion / Conclusions: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol is efficient to improve symptoms of chronic upper patellar tendinopathies, non-responsive to classical conservative treatments. However, up to now, there is no consensus on the method to prepare the PRP. Indeed, each technique could provide a very different PRP (variations in the platelet concentrations and of the amount of red and white cells). [less ▲]

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See detailMosquito net for abdominal wall repair: a comparison of their chemical, physical, morphological and mechanical properties to commercial meshes
Sevrin, Chantal ULg; Nsadi Fwene, Berthier; Arung, Willy et al

in Biomedica proceedings (2013, June 23)

Meshes are the actual standard in abdominal wall repair. Commercial medical meshes are however either unavailable or unaffordable too expensive for developing countries. Therefore in most resource-poor ... [more ▼]

Meshes are the actual standard in abdominal wall repair. Commercial medical meshes are however either unavailable or unaffordable too expensive for developing countries. Therefore in most resource-poor developing countries a traditional sutured repair is still commonplace although with significantly inferior results. Sterilized mosquito nets have been recently roposed by several authors to replace medical meshes in low-income countries . However in the perspective of their clinical use a better understanding of this mosquito net is obviously requested both in terms of material properties and of in vivo biocompatibility. [less ▲]

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See detailCan we use electrical resistivity tomography to measure root zone competition in fields with multiple crops?
Garré, Sarah ULg; Coteur, Ine; Wongleecharoen, Chalemchart et al

in Procedia Environmental Sciences (2013, June 20)

Contour hedgerow intercropping systems have been proposed to reduce run-off and control soil erosion on steep agricultural land. However, competition for water and nutrients between crops and associated ... [more ▼]

Contour hedgerow intercropping systems have been proposed to reduce run-off and control soil erosion on steep agricultural land. However, competition for water and nutrients between crops and associated hedgerows may reduce the overall performance of these systems. ERT measurements conducted in Thailand showed that the soils of our experimental plots were very heterogeneous both along the slope as with depth. This observation highlighted some constraints of the ERT method for soil moisture monitoring in the field. Nevertheless, the data indeed revealed contrasting water depletion patterns under monocropping and intercropping systems, which could also be related to plant parameters. [less ▲]

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See detailExcitation of nodal diameter mode-shapes of a stator ring of a turbojet engine using a limited number of excitation sources
Nyssen, Florence ULg; Golinval, Jean-Claude ULg; Viguié, Régis et al

in Proceedings of ASME Turbo Expo 2013 (2013, June 05)

When considering engine tests, the sensors used to monitor the rotor parts mainly consist in strain gauges whose information is very sensitive to the gauge positioning, especially in high stress gradient ... [more ▼]

When considering engine tests, the sensors used to monitor the rotor parts mainly consist in strain gauges whose information is very sensitive to the gauge positioning, especially in high stress gradient regions. Therefore, to reduce the risk of misinterpreting the response given by the gauges, their calibration is required. Because strain gauges are positioned so that specific modes will be monitored, their calibration must be carried out for these modes. For cyclic symmetric structures, their high spectral density imposes the use of dedicated calibration techniques. In the present paper, the concept of modal appropriation is investigated as the first step of the calibration procedure. This paper aims at presenting the development of an experimental approach enabling the isolation/appropriation of specific nodal diameter modes of a stator stage of an axial compressor using a limited number of excitation sources. A special emphasis has been brought to the minimum number and the optimized location of the excitation sources (shakers) required in laboratory conditions to appropriate specific nodal diameter modes and thereby retrieve the related modal features needed for the gauges calibration and mechanical design. [less ▲]

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See detailAmbulatory Monitoring of Teachers' Voice Use
Remacle, Angélique ULg; Morsomme, Dominique ULg; FINCK, Camille ULg

in AQL Proceedings (2013, June)

Method: Thirty-two French-speaking female teachers were monitored during one workweek (5 days) using the Ambulatory Phonation Monitor, Model 3200 (KayPENTAX). Phonation time, fundamental frequency (F0 ... [more ▼]

Method: Thirty-two French-speaking female teachers were monitored during one workweek (5 days) using the Ambulatory Phonation Monitor, Model 3200 (KayPENTAX). Phonation time, fundamental frequency (F0), sound pressure level (SPL), distance dose and cycle dose were analyzed in both professional and non-professional environments. Results: Teachers’ phonation time was statistically higher at school (20.3% ± 4.2) than not at school (10.4% ± 3.8). Concerning the fundamental frequency, both F0 average and F0 mode were statistically higher in the professional environment (F0 average = 258.7 Hz ± 20.5; F0 mode = 229.7 Hz ± 18.3) than in the non-professional environment (F0 average = 239.6 Hz ± 20.1; F0 mode = 213.3 Hz ± 20.6). The teachers spoke statistically louder at school (80.6 dB SPL ± 4.9) than not at school (74.5 dB SPL ± 5.2 dB SPL). The cycle dose and the distance dose were also statistically higher at school than in the non-professional environment. The data showed that the vocal folds vibrate 1,195,834 (± 255,696) times a day at work, plus 425,102 (±194,338) times after work. The distance traveled by the vocal folds for these teachers was 4,247 (± 1,476) meters at work, plus 1,173 (± 527) meters after work. Conclusion: Professional and non-professional voice use comparisons showed significant differences for all parameters (p<.001), indicating that vocal load was higher in the professional environment compared to the non-professional environment. [less ▲]

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See detailDrug related problems and interventions of pharmacists on prescribed medicines in Belgium
De Wulf, Isabelle; Boussery, Koen; De Vriese, Carine et al

in International Journal of Clinical Pharmacy [=IJCP] (2013, June), 35(3), 497

Aim of project/study (1) To study the frequency and nature of drug related problems (DRP) detected by community pharmacists and internship students when dispensing prescribed medicines. (2) To investigate ... [more ▼]

Aim of project/study (1) To study the frequency and nature of drug related problems (DRP) detected by community pharmacists and internship students when dispensing prescribed medicines. (2) To investigate the nature and frequency of interventions by pharmacists. (3) To study whether there is a difference between DRP detection at the moment of dispensing versus in a quiet setting. [less ▲]

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See detailExuberant inflammatory reaction after an infiltration of platelet-rich plasma (PRP)
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; LEONARD, Philippe ULg et al

in British Journal of Sports Medicine (2013, June), 47(10 (e3)), 92

Background: PRP, obtained from centrifuged autologous blood, contains a large quantity of growth factors, which may enhance the tissue healing processes. Local infiltration of PRP represents a relatively ... [more ▼]

Background: PRP, obtained from centrifuged autologous blood, contains a large quantity of growth factors, which may enhance the tissue healing processes. Local infiltration of PRP represents a relatively new treatment for tendinopathies. To date, no side effects have been reported after infiltration of PRP to treat tendinopathy. Case report: A 35-year-old patient had a right upper patellar tendinopathy which was resistant to all conservative treatments for more than 6 months. The patient was a type 1 diabetic (well controlled). He had an intratendinous infiltration of 6 mL of PRP (8.105 platelets/mm3, almost no red or white blood cells) after disinfection but without local anaesthetic. Immediately following the infiltration, local cryotherapy was performed for 15 minutes. NSAIDs were avoided, but class-1 or -2 pain-killers were authorised if necessary. A standardised sub-maximal eccentric rehabilitation should have been started 1 week after. However, the patient experienced local swelling with erythema, increased heating and pain which appeared just underneath the patella, but without biological inflammatory syndrome. A great Doppler signal in a thicker patellar tendon was observed by US, but there was no sign of local infectious disease demonstrated by either CT or MRI. However, the local inflammation did not decrease after a progressive 3-week treatment of local cryotherapy, local and oral NSAIDs and colchicine 1 mg. Thus, an insidious infection was suspected, even though there was neither evidence of biological inflammatory syndrome nor sign of infectious lesion on imagery examination. An antibiotic therapy (rifampicine 600 mg + minocycline 100 mg) was initiated for 3 months. Finally, a 3-phase bone scintigraphy suggested the presence of a complex regional pain syndrome type 1 treated by a classical physical therapy and concomitant class-2 pain killers. The evolution was favourable after 6 months of symptomatic treatment, and the pain decreased to a level similar to that before the infiltration of PRP. Discussion/Conclusions: This case report draws attention to potential side effects that are linked to this new therapy by infiltration of platelet rich plasma in case of tendinopathy, in particular when used in patients with type 1 diabetes. Thus, the balance between benefits and risks must be carefully evaluated before using this treatment in patients with type 1 diabetes. Reference: Platelet-rich plasma application in the management of chronic tendinopathies. Acta Orthop Belg 2013; 79: 10-15. [less ▲]

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See detailHigh-speed imaging use to predict spray retention on barley leaves
Boukhalfa, Hassina dite Hafida ULg; Massinon, Mathieu ULg; Lebeau, Frédéric ULg

in Communications in Agricultural and Applied Biological Sciences (2013, May 21), Vol 78(2)(1-386 (2013)), 31-36

Laboratory studies were conducted to validate the effectiveness of the use of high-speed imaging method to replace chemical nalysis by fluoremetrie. Measurements were performed with a high-speed camera ... [more ▼]

Laboratory studies were conducted to validate the effectiveness of the use of high-speed imaging method to replace chemical nalysis by fluoremetrie. Measurements were performed with a high-speed camera coupled with a retro-LED lighting. Size and velocity of the drop were extracted by image analysis. Drop impact types were determined by the operator. Drops were produced with a flat-fan nozzle mounted on a movable ramp. Two surfactants (Break-Thru® S240 and Li700 ®) were sprayed on BBCH 12 barley leaves to highlight the effect of the reduction of surface tension. Relative volume proportions were computed within of an energy scale divided into 11 classes based on the Weber number. results are compared to the results of the chemical analysis by spectrofluerometry. [less ▲]

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See detailSilky bent grass resistance to herbicides: one year of monitoring in Belgium
Henriet, François; Bodson, Bernard ULg; Meza Morales, Walter ULg

in Communications in Agricultural and Applied Biological Sciences (2013, May 21), 78(3), 665-670

Silky bent grass (Apera spica-venti (L.) P. Beauv.) is a common weed of cereal crops widely spread in Northern and Easthern Europe (Germany, Czech Republic, ...), Northern Asia, Sibera and Canada. Up to ... [more ▼]

Silky bent grass (Apera spica-venti (L.) P. Beauv.) is a common weed of cereal crops widely spread in Northern and Easthern Europe (Germany, Czech Republic, ...), Northern Asia, Sibera and Canada. Up to now, no resistant case has been detected in Belgium but some chemical weeding failures have been observed in Wallonia fields. During summer 2011, 37 seed samples of Apera spica-venti were collected in Wallonia and submitted to resistance tests in controlled conditions. Three modes of action were tested: acetyl coenzyme-A carboxylase inhibitors (pinoxaden and cycloxydim), acetolactate synthase inhibitores (mesosulfuron+iodosulfuron, pytroxsulam and sulfometuron) and photosynthesis inhibitors (isoproturon). One susceptible standard population was included in the test in order to validate it and to permit wild populations classification according to "R" rating system developed by Moss et al (2007). Most of populations were susceptible but some populations showed resistance to at least one of the three tested modes of action. [less ▲]

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See detailRace Cycling: biological evolution
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; MELON, Pierre ULg et al

in Biochimica Clinica (2013, May), 37(SS), 544

Background: The metabolic and cardiac impact of a cycling effort on blood biology is not very well described in the literature. We aimed to measure the concentration of different biomarkers (cardiac and ... [more ▼]

Background: The metabolic and cardiac impact of a cycling effort on blood biology is not very well described in the literature. We aimed to measure the concentration of different biomarkers (cardiac and metabolic) released during an international cycling race. Methods: Venous blood samples of 15 young men (25.1 ± 6.4 y.o.) were collected just before (T1), just after (T2), 3 hours (T3) after an international cycling race of 179.6 kilometers in Belgium for the determination of cardiac and metabolic biomarkers: red blood cell (RBC), haemoglobin (HgB), creatinin (Cr), highly sensitive troponin T (hsTnT), myoglobin (MYO) and NT-proBNP. All automated assays were performed according to the manufacter’s specifications. For the statistical analysis, an Anova calculated with the Statistica Software version 9.1 was used. Results: RBC and HgB levels varied significantly between T0 and T3 (respectively p=0.0026, and p=0.002). Cr concentration also varied significantly between all times (T0-T1:p<0.0001, T1-T3:p=0.0326 and T0-T3 p=0.0001). These changes might be related to renal flow depletion during exercice. MYO increased significantly between T0 and T1 (p<0.0001), but quickly decreased between T1 and T3, however the T3 level stay higher than T0 (p=0.014). The stress delivered from the physical activity performed during the race induced a significant variation of hsTnT which increased significantly between T0 and T1 (p<0.0001) and stayed higher 3 hours after the end of the exercise (T0-T3: p<0.0001) .The intense exercise delivery by the race induced a significant variation of NT-proBNP, that followed the same kinetic of hsTnT but in smaller proportion. We noticed variations statistically significant between T0 and T1 and between T0 and T3 for NT-proBNP. These increases of cardiac biomarkers were significant but reasonable and could not allow us to talk about cellular necrosis or irreversible injury. Conclusion: Our results show that stress generated by a cycling race could be the cause for the different metabolic variations observed. Troponin T stays without a doubt the most specific marker for stress related to myocardial tissue. Its increase can then be considered as being of interest. [less ▲]

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See detailEvaluation of the performance of the new automated IDS-ISYS 1,25-dihydroxy vitamin D assay
GADISSEUR, Romy ULg; LUKAS, Pierre ULg; CARLISI, Ignazia ULg et al

in Biochimica Clinica (2013, May), 37(SS), 498

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See detailIs ultra-short cold ischemia the key to ischemic cholangiopathy avoidance in DCD-LT?
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Cheham, S et al

in Acta Chirurgica Belgica (2013, May), Supplement 113(3), 6729

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See detailHeavy/light chain (HLC) and free light chain (FLC) analysis allow sensitive monitoring of multiple myeloma patients and AID detection of clonal changes
Dierge, Laurine; LUTTERI, Laurence ULg; Chauvet, D et al

in Biochimica Clinica (2013, May), 37(SS), 618

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See detailEvaluation of the third-generation to second-generation PTH ratio on the Liaison XL (DIASORIN) as a marker for parathyroïd carcinoma
Schleck, Marie-Louise; LAURENT, Terry ULg; GADISSEUR, Romy ULg et al

in Biochimica Clinica (2013, May), 37(SS), 161

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See detailBiophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline ULg; Nasir, Mehmet Nail ULg; Nott, Katherine ULg et al

in World Academy of Science, Engineering and Technology (2013, May), 77

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic ... [more ▼]

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed. [less ▲]

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See detailEconomie et formation des Humanités: quelle politique?
Janvier, Antoine ULg

in Dissensus (2013, May), 5

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See detailBiophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline ULg; Nasir, Mehmet Nail ULg; Nott, Katherine ULg et al

in World Academy of Science, Engineering and Technology (2013, May), 77

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic ... [more ▼]

Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed. [less ▲]

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See detailComparison of the Heart-type fatty acid-binding protein (H-FABP) with the high sensitive cardiac troponin T in healthy runners
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; BREVERS, Eric ULg et al

in Biochimica Clinica (2013, May), 37(SS), 544

Background: Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. It is an early marker ... [more ▼]

Background: Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. It is an early marker for acute coronary syndrome. Troponin T (TnT) is a component of the contractile apparatus of the striated musculature. Cardiac TnT is a cardio-specific, highly sensitive marker for myocardial damage. The aim of our study was to compare the results obtained with the H-FABP and the highly sensitive cardiac troponins (hsTnT) and to test their cardiospecificity in healthy runners. Methods: Twenty three runners (marathon) were enrolled. We drowned samples at three times: just before (T0), just after (T1), and three hours after the end of the race (T3). H-FABP was determined with a Randox immunoturbidimetric assay and hs-TnT with a Roche electrochemiluminescence immunoassay, both on Cobas 6000. A linear regression was calculated to observe if there is any correlation between the two biomarkers. Values above the 95th percentile for H-FABP (2.5ng/mL) and the 99th percentile for hsTnT (14ng/L) were considered as positive. Results: At T0, none of the subjects were positive for hsTnT but 35% were positive for H-FABP; at T1, 83% for hsTnT and 100% for H-FABP; at T3, 83% for hsTnT and 96% for H-FABP. At T0, the regression equation was H-FABP T0 = 3.9454 – 0.1001 x hsTnT T0; at T1: H-FABP T1 = 51.838 – 1.7026 x hsTnT T1; at T3: H-FABP T3 = 47.977 – 1.6193 x hsTnT T3. No correlation was observed between the two biomarkers at the different time. Conclusions: We observed a significant increase of H-FABP and hsTnT in runners. These markers are independent to each other. These values could biologically correspond to a heart ischemia. However, we suggested that exercise-induced cardiac hsTnT and H-FABP release is not a marker of exercise-induced pathology but likely a physiologic response to effort or an exercise-induced cardiac remodelling. [less ▲]

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See detailComparison between Perkin-Elmer and Chromsytem Vitamin D kit on TQ 5500 from AB SCIEX
LE GOFF, Caroline ULg; PEETERS, Stéphanie ULg; CRINE, Yannick ULg et al

in Biochimica Clinica (2013, May), 37(SS), 471

Background: Twenty-five hydroxy-vitamin D (25(OH) D) determination is now routinely prescribed in the Laboratory. Recently, different new methods have been available for this determination. Among them ... [more ▼]

Background: Twenty-five hydroxy-vitamin D (25(OH) D) determination is now routinely prescribed in the Laboratory. Recently, different new methods have been available for this determination. Among them, LCMS/MS methods have emerged in some laboratories. However these methods are generally “home-brewed” and an important variability between them can be seen on different external quality controls, mainly due to a lack of standardization. Recently, Perkin-Elmer (PE) (Turku, Finland) and Chromsystem (CS) (Grafelfing, Germany) launched a standardised method for 25(OH )D determination on LCMS/MS. The aim of our study was to compare these methods on the AB SCIEX TQ5500 (Framingham, Massachusetts, USA) LCMS/MS to measure 25(OH) D3. Methods All the samples were treated according to our preanalyitical procedure: after sampling, they were spun at +4°c at 3500G, aliquoted and kept frozen at -20°c until determination. A method comparison was assessed with CS and PE for the measurement of the 25(OH)D3. We selected 110 remnant samples with 25(OH)D3 levels ranging from 1.6 to 136.7 ng/ml with the PE method to cover the range of usually values Slope and intercept were calculated using Passing and Bablock linear regression and we compared the methods with the Bland and Altman plots. Results For CS, the method is linear up to 250 µg/L, the LOQ is 3.6 µg/L, the intra-assay CV is < 5% and the inter-assay is < 7%. For PE, the method is linear up to 314 µg/L, the LOQ is 3.4 µg/L, the intra-assay CV is < 7.8% and the inter-assay is < 8.5%. On the whole range of measure (n=110), the regression equation is PE = 0.8521+0.9226 (CS) (95%CI of the intercept: (-0.0048;1.37) and 95% CI of the slope (0.89;0.95). The Bland and Altman plot does not show any bias between the two methods (mean difference CS-PE= -2.5 ng/ml) and the standard deviation of the mean is 3,98 ng/ml Conclusion: The performances of these methods are comparable on our new TQ 5500 from AB SCIEX. For now, there is no consensus on a “reference” method for vitamin D quantification. We notice only that the values obtained by CS are systematically a little bit lower than PE’s values, especially for results below 20 ng/ml. However, we have no clear explanation for such behaviour. [less ▲]

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See detailImpact of strenuous exercise on the release of cardiac biomarkers
LE GOFF, Caroline ULg; MELON, Pierre ULg; Kaux, Jean-François ULg et al

in Biochimica Clinica (2013, May), 37(SS), 545

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured ... [more ▼]

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured by new commercially available high-sensitive methods in subjects un-dergoing the Maasmarathon. Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Methods: Twenty eight subjects (26 ♂, 42.5±11yo) underwent a race of 42.195 kilometers be-tween Visé (Belgium) and Maastricht (The Netherlands). We drowned blood sample before (T0), just after (T1) and three hours after the race (T3). In all patients, cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. The protocol was approved by the ethics committee of the University of Liège (Belgium). All subjects gave their informed consent. All statistical analyses were performed using Medcalc version 8.1 for Windows. p-value <0.01 was regarded as statistically significant. Results: There was a significant difference between hsTnT concentrations at T0 and T1 (p<0.0001), and between T0 and T3 (p<0.001) for NT-proBNP, but not between T1 and T3. This observation appeared only after a strenuous exercise but today this type of exercise is not reproduce easier in a laboratory of sport. Moreover, at this moment, nobody knows if these observations would have cardiac consequences at long terms. Conclusions: Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death. [less ▲]

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