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See detailDetailed sedimentological study and magnetic susceptibility of and Eifelian mixed ramp-related system in the Eifel area
Pas, Damien ULg; Mabille, Cédric; Aretz, Markus et al

in Geologica Belgica (2010, December), 13(4),

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See detailMagnetic susceptibility correlation of km-thick Eifelian-Frasnian sections (Belgium-Czech Republic)
Boulvain, Frédéric ULg; Da Silva, Anne-Christine ULg; Mabille, Cedric et al

in Geologica Belgica (2010, December), 13(4), 5-7

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See detailCellular uptake of long-circulating pH-sensitive liposomes: evaluation of the liposome and its encapsulated material penetration in cancer cells
Ducat, Emilie ULg; Deprez, Julie ULg; Peulen, Olivier ULg et al

in Drug Discovery Today (2010, December), 15(23-24), 1079-1114

Print 3G, a peptidic antagonist of oncoprotein involved in breast cancer, could reduce the angiogenic development of breast tumors, leading to tumor dormancy. The necessity of intravenous administration ... [more ▼]

Print 3G, a peptidic antagonist of oncoprotein involved in breast cancer, could reduce the angiogenic development of breast tumors, leading to tumor dormancy. The necessity of intravenous administration of Print 3G led to the development of long-circulating liposomes as drug carriers. Pegylated liposomes, too large to be collected by fenestrated organs, accumulate passively in solid tumors thanks to the EPR effect. The strategy was to combine the protective properties of PEG with the transfection properties of pH-sensitive lipids which could promote the uptake of liposomes by cells and avoid lysosomal sequestration and degradation of entrapped materials such as peptides. In this study, we compare two formulations in terms of cellular uptake using confocal microscopy. The first one is composed of SPC:CHOL:mPEG-750-DSPE (47:47:6), used as "standard" liposomes, and the second one of DOPE:CHEMS:CHOL:mPEG750-DSPE (43:21:30:6), used as pH-sensitive liposomes. First, we evaluated the penetration of an encapsulated model molecule, calcein, in Hs578t human breast cancer epithelial cells. When calcein was encapsulated in standard liposomes, its penetration was effective only in few cells. On the contrary, a majority of cells were fluorescent when calcein-loaded pH-sensitive liposomes were applied for 3 hours on cells. Secondly, we studied the penetration of liposomes themselves in Hs578t cells using 25-[(nitrobenzoxadiazolyl)methylamino]nor-cholesterol (NBD-CHOL) as a fluorescent marker of the phospholipid membrane. The obtained results were comparable to those obtained with calcein: a higher penetration of liposome was observed for pH-sensitive liposomes. Finally, the cellular uptake of liposomes using both NBD-CHOL and rhodamine encapsulated in the inner cavity of vesicles was evaluated with Hs578t cells and compared with WI26 human diploid lung fibroblast cells. Thanks to this experiment, we could follow simultaneously the cell distribution of the encapsulated material and of the liposome itself. Confocal pictures obtained with pH-sensitive liposomes on both WI26 and Hs578t cells allow us to visualize the co-localized red and green colors of rhodamine and NBD-CHOL, with a higher concentrated area near the nucleus. In comparison with "standard" liposomes, we observed a higher penetration of the encapsulated material and of the liposome itself in breast cancer cells. Moreover, we visualized a colocalization near the nucleus of liposomes components. Concerning results obtained with fibroblastic cells, there was no difference in terms of cellular uptake between the two formulations. In perspective, we would like to compare these results, obtained with model molecules, with experiments performed with biotinylated Print 3G to assess its cellular distribution. Moreover, it would be interesting to correlate results obtained with confocal microscopy with a possible increase of the peptide efficacy against cancer cells when it is encapsulated in long-circulating pH-sensitive liposomes. [less ▲]

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See detailRehabilitation in osteoporosis
Bruyère, Olivier ULg

in Proceedings of the annual congress of the Royal Belgian Society of Physical and Rehabilitation medicine (2010, December)

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See detailEvolution of the Kızılırmak river and its interaction with the North Anatolian Fault, Turkey
Drab, Laureen; Hubert, Aurelia ULg; Benedetti, Lucilla et al

in AGU Abstract (2010, December)

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See detailAltération du mouvement lombo-pelvien chez les danseurs. Valeur prédictive et interprétation clinique
Roussel, Nathalie; Demoulin, Christophe ULg

in Kinesitherapie Revue (2010, December), 108

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See detailÉvaluation clinique du patient lombalgique chronique : état des lieux
Roussel, Nathalie; Demoulin, Christophe ULg

in Kinesitherapie Revue (2010, December), 108

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See detailLe renforcement instrumentalisé des muscles du tronc
Vanderthommen, Marc ULg; Demoulin, Christophe ULg; Grosdent, Stéphanie ULg et al

in Kinesitherapie Revue (2010, December), 108

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See detailControl of hypertension in a kidney transplanted population : the EPARA study
Gellner, Karen; Saint-Remy, Annie ULg; Weekers, Laurent ULg et al

in Acta Clinica Belgica (2010, November 27), 66(1), 79

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See detailDe la Carte des Sols de la Belgique à la Carte Numérique des Sols de Wallonie : vers des Systèmes Régionaux d'Information sur les Sols et leurs propriétés
Legrain, Xavier ULg; Demarcin, Pierre ULg; Colinet, Gilles ULg et al

in Bulletin du groupe francophone humidimétrie et transferts en milieux poreux (2010, November 25), 56

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See detailSUIVI D'UN TEST GEOTHERMIQUE PEU PROFOND DANS UN AQUIFERE SABLEUX PAR TOMOGRAPHIE DE RESISTIVITE ELECTRIQUE : ETUDE DE FAISABILITE
Hermans, Thomas ULg; Vandenbohede, Alexander; Nguyen, Frédéric ULg et al

in Bulletin du groupe francophone d'humidimétrie et transferts en milieux poreux (2010, November 24), 56(Novembre 2010), 21-26

A shallow thermal test was monitored with electrical resistivity tomography (ERT). Heated water (48°C) was injected in a sandy aquifer (10°C). Laboratory measurements indicated a change of 2.1 %/°C of ... [more ▼]

A shallow thermal test was monitored with electrical resistivity tomography (ERT). Heated water (48°C) was injected in a sandy aquifer (10°C). Laboratory measurements indicated a change of 2.1 %/°C of water electrical conductivity for injection water. Due to this change, the plume of heated water was detected by geophysical imaging. In parallel, a hydrogeological flow and heat transport model was calibrated. Geophysics brought important information to calibrate this model and to show the heat exchange through the unsaturated zone. The comparison of the two models shows that ERT was able to retrieve the position and the temperature of the plume. However, a distortion occurs due to the smoothing of the solution during the regularized inversion process. This work demonstrates the ability of ERT to help quantifying parameters governing heat transport in the subsurface non-invasively and therefore studying and designing heat and storage experiments for shallow reservoirs. [less ▲]

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See detailAnalysis of fetal death in relation with increased fetal nuchal translucency thickness in the south of Vietnam
To, Hong ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Asian Federation of Societies for Ultrasound in Medicine and Biology (2010, November 18)

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton ... [more ▼]

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton pregnancies were measured fetal NT thickness and performed free beta subunit of human Chorionic Gonadotropin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) routinely in the first trimester, then scanned systematically for fetal structure by ultrasonography at the second trimester of gestation, next followed to their delivery and examined neonatal status. For suspicion of fetal abnormality, amniocentesis was indicated to confirm a fetal karyotype. Fetal abnormal chromosome was counselled a termination of pregnancy (TOP). 5 groups of fetal NT thickness was divided: group of normal fetal NT thickness (< 2.4mm), group of mild increased of fetal NT thickness (2.4-3.4mm), group of moderate increased fetal NT (3.5-4.4mm), group of severe fetal NT (4.5-5.4mm) and group of very severe fetal NT (≥ 5.5mm). We evaluated the fetal deaths (included spontaneous abortion, fetal death intra-uterine, and terminated pregnancy due to aneuploidy and/or structural abnormality), then look for a relation between an increased fetal NT thickness and those fetal adverse outcomes. Results: Fetal NT thickness cut-off point at 2.4mm or more was defined as an increased fetal NT thickness with 65.5% of sensitivity for fetal abnormal detection. 5.3% (133/2500) was the prevalence of increased fetal NT thickness. 2.8% (71/2500) of cases had been indicated an amniocentesis. A total incidence of fetal death was found 1.5% (37/2500). In group of fetal NT thickness < 2.4mm, the rate of abnormal karyotype was 0.4% (10/2367), none case of fetal deaths obtained. In the fetal NT group of 2.4-3.4mm, total of fetal death found 26.4% (32/121) that included 12.4% (15/121) of abnormal karyotype, 8.3% (10/121) of abnormal ultrasound scanning, 5.8% (7/121) of fetal demised, and 0.8% (1 case) of neonatal defect due to G6PD deficiency. In the group of 3.5-4.4mm, 33.3% (3/9) of fetuses were died (22.2% was due to aneuploidy and 11.1% was due to miscarriage spontaneously). In the group of 4.5-5.4mm, 1 case (50%) of trisomy 18 was detected and in the group of ≥ 5.5mm, 1 case (100%) of trisomy 21 had been diagnosed. When fetal NT thickness increased, the possibility of fetal demised was higher significantly: likelihood ratio (LR) augmented from 15.2 in the fetal NT group at 2.4-3.4mm to 169.5 in fetal NT group at ≥ 5.5mm (p < 0.01, Pearson chi2). Conclusion: An increased fetal NT thickness was useful finding for prediction of fetal deaths (included fetal abortion, demised or terminated) in the prenatal diagnosis and care program in the South of Vietnam. [less ▲]

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See detailMemantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: Exemplified by an mGlu2/3 receptor agonist
Dedeurwaerdere, S.; Wintmolders, C.; Straetemans, R. et al

in Society-for-Neuroscience Abstracts/Annual Meeting Publications (2010, November 17), 40

Schizophrenia is a severe, disabling chronic disorder affecting approximately 1% of the population. Unfortunately, patients afflicted by this difficult to treat psychiatric illness remain stigmatized and ... [more ▼]

Schizophrenia is a severe, disabling chronic disorder affecting approximately 1% of the population. Unfortunately, patients afflicted by this difficult to treat psychiatric illness remain stigmatized and are likely to suffer permanent cognitive and social deficits. Improvements and development of more robust and hopefully predictive screening assays for this disease should enhance the identification and development of novel treatments. The present study describes a rapid and robust method for the testing of potential novel antipsychotics by utilising a simplified [14C]2-deoxyglucose (2-DG) uptake autoradiography technique following memantine-induced brain activation. Male C57BL/6JCRL mice were treated with either vehicle, ketamine (30 mg/kg, s.c.) or memantine (20 mg/kg, s.c.). Both NMDA antagonists induced significant increases in 2-DG uptake in specific brain region such as lateral orbital cortex, olfactory tubercle, piriform cortex, cingulate cortex, retrosplenial cortex, lacunosum molecular layer of the hippocampus and the lateral posterior thalamic nucleus. Interestingly, memantine elicited a more robust brain activation signature with a larger dynamic window than ketamine. For further characterisation of the assay, we also tested the effect of diet (fasting versus non-fasting) and different vehicles. In addition, dedicated software, developed particularly for this assay, was evaluated for automated quantification of the brain sections. In subsequent reversal studies, we found that in accordance to the ketamine challenge model (Duncan et al. 1998), the “atypical” anti-psychotic clozapine (2.5 and 10 mg/kg, s.c.) significantly reversed memantine-induced 2-DG uptake whilst the “typical” anti-psychotic haloperidol (0.32 mg/kg, s.c.) was inactive thus further validating our choice of memantine for the challenge agent. An additional study then determined the effects of a mGlu2/3 receptor agonist on both ketamine and memantine-induced brain activation. Pre-treatment with LY404039 (10 mg/kg, s.c.) fully reversed both the ketamine and memantine-induced increase in 2-DG uptake without effects on basal 2-DG uptake. Finally, a small animal PET study was performed with [18F]-FDG in mice and rats investigating the effect of memantine (20 mg/kg) administration in vivo. This study confirmed the memantine-induced brain activation previously demonstrated by autoradiography. In conclusion, this novel pre-clinical method shows potential for the screening of compounds targeting the NMDA receptor hypofunction hypothesis of schizophrenia and may assist in translating these findings from the bench to clinic. [less ▲]

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See detailApproches comparées de l'entrepreneuriat social en Europe et aux Etats-Unis
Defourny, Jacques ULg

in Revue Internationale de l'Economie Sociale : Recma, Revue des Etudes Coopératives, Mutualistes et Associatives (2010, November 09)

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See detailLiposomes loaded with diglyceride esters of methotrexate and mephalan studies on stability and hemocompatibility
Kuznetsova, N; Kandyba, A.K.; Bovin, N et al

in European Cells and Materials (2010, November 03), 20(3), 152

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See detailNew advances in asteroseismology of pulsating hot subdwarf stars
Charpinet, S.; Van Grootel, Valérie ULg; Randall, S. K. et al

in Highlights of Astronomy (2010, November 01), 15

Hot subdwarf stars (of the sdB and sdO type) host three known classes of nonradial pulsators. Two of them feature short period (P ~ 60 - 600 s) accoustic mode oscillations, while the third group is ... [more ▼]

Hot subdwarf stars (of the sdB and sdO type) host three known classes of nonradial pulsators. Two of them feature short period (P ~ 60 - 600 s) accoustic mode oscillations, while the third group is characterized by slow g-mode deformations with periods of ~ 1 - 2h. These pulsations offer favorable grounds to infer some of the internal properties of these objects through asteroseismology. This has been exploited for the rapid p-mode sdB pulsators and the present contribution reviews some of the recent advances in this field. The long period g-mode pulsators, whose vibrations probe much deeper inside the star, are also of high interest. With the advent of space observations using CoRoT and KEPLER, the asteroseismology of these slower oscillators will also become a possibility, and likely contribute to significant breakthroughs in our understanding of these hot and compact stars. [less ▲]

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See detailPhase 2 Results of XL184 in a Cohort of Patients with Advanced Melanoma
Nechushtan, Hovav; Edelman, Gerald; JERUSALEM, Guy ULg et al

in EJC Supplements (2010, November), 8(7), 126-127

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See detailAdding value to test-day data by using modified best prediction method
Gillon, Alain ULg; Abras, Sven; Mayeres, Patrick et al

in ICAR Technical Series (2010, November), 14

Computation of lactation yields from test-day data has lost much of its importance for genetic evaluations as the use of test-day models is currently quite widespread. In the other hand its interest for ... [more ▼]

Computation of lactation yields from test-day data has lost much of its importance for genetic evaluations as the use of test-day models is currently quite widespread. In the other hand its interest for intra-farm management is increasing as a base for advanced management tools. The first and principal aim of this study was to develop a method which takes into account advantages and disadvantages of existing methods, and to test its potential to provide useful management tools to dairy farmers. A test-day model with modifications to able daily run and management tools was developed. Because of its similarities with best prediction, the method developed here was called modified best prediction. The second objective was to compare the accuracy of this new method with best prediction and test interval methods. Modified best prediction showed good results for predicting daily yields and was slightly better than best prediction for lactation yields prediction. Management tools obtained with modified best prediction are explained. [less ▲]

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See detailNutritive value of fibrous ingredients fed to pigs in the Democratic Republic of Congo measured using an in vitro technique
Kambashi Mutiaka, Bienvenu ULg; Boudry, Christelle ULg; Picron, Pascale ULg et al

in Advances in Animal Biosciences (2010, November), 1(2), 423-424

Incorporation of forages in the diets can improve the economics of smallholder pig production in tropical countries. However, the information on the nutritive value of fibrous crop by-products and forages ... [more ▼]

Incorporation of forages in the diets can improve the economics of smallholder pig production in tropical countries. However, the information on the nutritive value of fibrous crop by-products and forages species used as ingredients in pig diets is scarce. The present work aimed at measuring the chemical composition and the nutritive value using an in vitro model of the pig gastro-intestinal tract of 21 ingredients used by farmers in the province of Bas-Congo (D.R. Congo). [less ▲]

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See detailTrend of hip fracture incidence in Belgium between 2000 and 2007 and future projections
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Detilleux, Johann ULg et al

in Value in Health (2010, November), 13(7), 303

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See detailEvaluation des peurs liées à la douleur du lombalgique chronique au moyen du PHODA (Photograph Series of Daily Activities)
Demoulin, Christophe ULg; Accary, Laure; Somville, Pierre-René ULg et al

in Revue du Rhumatisme (2010, November), 77(Supplément 3), 52-53

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See detailEvaluation du contenu du PHODA (Photograph Series of Daily Activities) par des spécialistes du rachis
Demoulin, Christophe ULg; Accary, Laure; Somville, Pierre-René ULg et al

in Revue du Rhumatisme (2010, November), 77(Supplément 3), 52

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See detailPour en finir avec la génération Y. Enquête sur une représentation managériale
Pichault, François ULg; Pleyers, Mathieu

in Actes des Congrès de l'AGRH (2010, November)

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See detailLe ranélate de strontium augmente la viabilité de chondrocytes humains stimulés par IL-1 bêta
Merville, Marie-Paule ULg; Deroyer, Céline ULg; Bruyère, Olivier ULg et al

in Revue du Rhumatisme (2010, November), 77(Suppl.3), 222

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See detailRanélate de strontium : efficacité à long terme sur 10 ans chez les femmes ménopausées ostéoporotiques
Reginster, Jean-Yves ULg; Kaufman, Jean-Marc; Goemaere, S. et al

in Revue du Rhumatisme (2010, November), 77(Suppl.3), 99-100

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See detailEvolution des structures de sols sous itinéraires techniques contrastés : relations entre courbes de rétention et analyse par microtomographie à rayons X
Beckers, Eléonore ULg; Roisin, Christian; Léonard, Angélique ULg et al

in Milieux Poreux et Transferts Hydriques (2010, November), 56

Tillage reduction seems to affect porosity distribution, orientation and connectivity. Soil samples were removed from plots under conventional tillage or reduced tillage. Their water retention curves were ... [more ▼]

Tillage reduction seems to affect porosity distribution, orientation and connectivity. Soil samples were removed from plots under conventional tillage or reduced tillage. Their water retention curves were measured, and the characterization of soils porosity was made using x-ray microtomography measurements. Results show differences in the meso as well as in the macroporosity. [less ▲]

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See detailCan an underestimation of opacity explain B-type pulsators in the SMC?
Salmon, Sébastien ULg; Montalban Iglesias, Josefa ULg; Miglio, Andrea ULg et al

in Astronomische Nachrichten (2010, October 09), 331(9-10),

Slowly Pulsating B and ß Cephei are ĸ mechanism driven pulsating B stars. That ĸ mechanism works since a peak in the opacity due to a high number of atomic transitions from iron-group elements occurs in ... [more ▼]

Slowly Pulsating B and ß Cephei are ĸ mechanism driven pulsating B stars. That ĸ mechanism works since a peak in the opacity due to a high number of atomic transitions from iron-group elements occurs in the area of log T ~ 5.3. Theoretical results predict very few SPBs and no ß Cep to be encountered in low metallicity environments such as the Small Magellanic Cloud. However recent variability surveys of B stars in the SMC reported the detection of a significant number of SPB and ß Cep candidates. Though the iron content plays a major role in the excitation of ß Cep and SPB pulsations, the chemical mixture representative of the SMC B stars such as recently derived does not leave room for a significant increase of the iron abundance in these stars. Whilst abundance of iron-group elements seems reliable, is the opacity in the iron-group elements bump underestimated? We determine how the opacity profile in B-type stars should change to excite SPB and ß Cep pulsations in early-type stars of the SMC. [less ▲]

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See detailThe PLATO End-to-End CCD Simulator -- Modelling space-based ultra-high precision CCD photometry for the assessment study of the PLATO Mission
Zima, W.; Arentoft, T.; De Ridder, J. et al

in Astronomische Nachrichten (2010, October 09), 331(9-10),

The PLATO satellite mission project is a next generation ESA Cosmic Vision satellite project dedicated to the detection of exo-planets and to asteroseismology of their host-stars using ultra-high ... [more ▼]

The PLATO satellite mission project is a next generation ESA Cosmic Vision satellite project dedicated to the detection of exo-planets and to asteroseismology of their host-stars using ultra-high precision photometry. The main goal of the PLATO mission is to provide a full statistical analysis of exo-planetary systems around stars that are bright and close enough for detailed follow-up studies. Many aspects concerning the design trade-off of a space-based instrument and its performance can best be tackled through realistic simulations of the expected observations. The complex interplay of various noise sources in the course of the observations made such simulations an indispensable part of the assessment study of the PLATO Payload Consortium. We created an end-to-end CCD simulation software-tool, dubbed PLATOSim, which simulates photometric time-series of CCD images by including realistic models of the CCD and its electronics, the telescope optics, the stellar field, the pointing uncertainty of the satellite (or Attitude Control System [ACS] jitter), and all important natural noise sources. The main questions that were addressed with this simulator were the noise properties of different photometric algorithms, the selection of the optical design, the allowable jitter amplitude, and the expected noise budget of light-curves as a function of the stellar magnitude for different parameter conditions. The results of our simulations showed that the proposed multi-telescope concept of PLATO can fulfil the defined scientific goal of measuring more than 20000 cool dwarfs brighter than mV =11 with a precision better than 27 ppm/h which is essential for the study of earth-like exo-planetary systems using the transit method. [less ▲]

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See detailOPRs of Ammonia versus 14N/15N Ratios in CN in 15 Comets
Shinnaka, Yoshiharu; Kawakita, H.; Kobayashi, H. et al

in Bulletin of the American Astronomical Society (2010, October 01), 42

The solar system was formed from interstellar matter 4.6 Gyrs ago and comets are considered as remnants of icy planetesimals formed in the early solar system. One of interesting primordial characters of ... [more ▼]

The solar system was formed from interstellar matter 4.6 Gyrs ago and comets are considered as remnants of icy planetesimals formed in the early solar system. One of interesting primordial characters of cometary ice is an ortho-to-para abundance ratio (OPR) of molecules such as H2O, NH3, etc. The OPR probably indicates the molecular formation temperatures in the solar nebula or in the pre-solar molecular cloud. We determined the OPRs of ammonia by using the high dispersion optical spectra of NH2 in 15 comets: C/1995 O1 (Hale-Bopp), C/1999 S4 (LINEAR), C/2001 A2 (LINEAR), C/2000 WM1 (LINEAR), 153P/Ikeya-Zhang, C/2002 V1 (NEAT), C/2002 X5 (Kudo-Fujikawa), C/2002 Y1 (Juels-Holvorcem), C/2001 Q4 (NEAT), C/2002 T7 (LINEAR), C/2003 K4 (LINEAR), 8P/Tuttle, 88P/Howell, 9P/Tempel 1, and 73P-B and -C/Schwassmann-Wachmann 3. The observations were mainly carried out by the Ultraviolet and Visual Echelle Spectrograph (UVES) mounted on the Very Large Telescope (VLT) in Chile. Other telescopes/instruments were also used in some cases. The OPRs of ammonia are determined from OPRs of NH2 (0,9,0) ro-vibronic band around 600 nm. Although absorption lines (by the telluric atmosphere) and cometary C2 emission lines blended affected to NH2 emission lines in this region, we removed them in our analysis. The determined OPRs of ammonia clustered around 30K but not in the cases of 73P-B and -C. This situation is very similar to that of 14N/15N ratios in CN (i.e., 73P-B and -C are quite peculiar relative to other comets). We discuss about the relationship between the OPRs of ammonia and 14N/15N ratios in CN in these 15 comets. Our results indicate the formation of materials at relatively higher temperatures for 73P-B and -C than other comets. [less ▲]

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See detailThe 3/4 July 2010 Pluto Stellar-Occultation Observations
Pasachoff, Jay M; Elliot, J. L.; Souza, S. P. et al

in Bulletin of the American Astronomical Society (2010, October 01), 42

Continuing our monitoring of Pluto's atmospheric temperature and pressure, previously shown by us to be increasing (Elliot et al., Nature 424, 165, 2003; Pasachoff et al., AJ 129, 1718, 2005) and ... [more ▼]

Continuing our monitoring of Pluto's atmospheric temperature and pressure, previously shown by us to be increasing (Elliot et al., Nature 424, 165, 2003; Pasachoff et al., AJ 129, 1718, 2005) and subsequently found by us to be leveling off (Elliot et al., AJ 134, 1, 2007), we report on a stellar occultation by Pluto of UCAC2 mag=15.3, observed from South America and Africa on 4 July 2010 UT. Success was achieved with a 0.45 m at Cerro Calan using one of our POETS (Portable Occultation, Eclipse, and Transit System; Souza et al. PASP 118, 1550, 2006), a 1.0 SMARTS (Small and Medium Aperture Research Telescope System) at Cerro Tololo, four 0.6 m telescopes of PROMPT (Panchromatic Robotic Optical Monitoring and Polarimetry Telescopes) on Cerro Tololo, and TRAPPIST's (TRansiting Planets and Planetesimals Small Telescope) 0.6-m telescope on La Silla in Chile; the 0.35 m telescope of U. Ponta Grossa, Brazil; and the 0.75-m ATOM (Automatic Telescope for Optical Monitoring), Namibia, using POETS. Winds prevented opening the 6.5 m Magellan/Clay telescope on Las Campanas, Chile, with its own frame-transfer camera, and clouds obscured the 1.9 m telescope at Sutherland, South Africa, which had POETS. With shadow velocity 23.6 km/s, it was a rapid event: maximum occultation <2 minutes. The observations were supported in part by grants NNX08AO50G to Williams College and NNX10AB27G to MIT from NASA's Planetary Astronomy Division, and NNH08AI17I to USNO for astrometry. Student participation was supported in part by NASA's Massachusetts Space Grant and NSF's REU. Japan's government donated U. Chile's Cerro Calan Goto telescope. PROMPT observations were made possible by the Robert Martin Ayers Science Fund. TRAPPIST is a project driven by the University of Liège, in close collaboration with the Observatory of Geneva, supported by the Belgian Fund for Scientific Research and the Swiss National Science Foundation. [less ▲]

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See detailComet 29P/Schwassmann-Wachmann Observed with the Herschel Space Observatory: Detection of Water Vapour and Dust Far-IR Thermal Emission
Bockelee-Morvan, Dominique; Biver, N.; Crovisier, J. et al

in Bulletin of the American Astronomical Society (2010, October 01), 42

The distant comet 29P/Schwassmann-Wachmann was observed with the HIFI, PACS and SPIRE instruments aboard the Herschel Space Observatory, as part of the guaranteed time key programme "Water and related ... [more ▼]

The distant comet 29P/Schwassmann-Wachmann was observed with the HIFI, PACS and SPIRE instruments aboard the Herschel Space Observatory, as part of the guaranteed time key programme "Water and related chemistry in the Solar System" (KP-GT HssO). Supporting observations of the 230 GHz CO line were carried out with the IRAM 30-m telescope. The HIFI observations of the 557 GHz H2O line were performed on 19.05 April 2010, about 2 days after a major outburst, and on 11.02 May 2010, when 29P was in a more quiescent phase. H2O was detected on both dates with a production rate corresponding to about 1/10th the CO production, assuming near-nucleus production. The H2O line shape is consistent with release of water vapour from icy grains. PACS and SPIRE imaging data from 70 to 500 micrometers were acquired mid-June 2010 when the comet was in a quiescent phase. The continuum emission detected in the 70-μm and 160-μm PACS images is weakly extended with respect to the PSF, suggesting a major contribution from the nucleus or from slowly moving large grains. [less ▲]

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See detailBiocompatible solid particles for controlled instigation of cavitation during therapeutic ultrasound.
Arora, Manish; Schiffter, Heiko; Manhas, Varun ULg et al

in Journal of the Acoustical Society of America (2010, October), 128(4), 2440

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See detailProgress in the asteroseismic analysis of the pulsating sdB star PG 1605+072
Van Grootel, Valérie ULg; Charpinet, Stéphane; Fontaine, Gilles et al

in Astrophysics & Space Science (2010, October), 329

The hot pulsating sdB star PG 1605+072 exhibits uncommon spectroscopic and pulsation properties, and is one of the biggest challenge in the field of sdB star modeling. Two hypotheses have been proposed to ... [more ▼]

The hot pulsating sdB star PG 1605+072 exhibits uncommon spectroscopic and pulsation properties, and is one of the biggest challenge in the field of sdB star modeling. Two hypotheses have been proposed to explain its unusually rich pulsation spectrum. The first is the natural explanation of a fast-rotating pulsator, which lifts the (2 l+1)-fold degeneracy of the frequency components. Another approach, where PG 1605+072 can be seen as a slow rotator, considers that the numerous low amplitude frequency components are second- and third-order harmonics and nonlinear combinations of the highest amplitude frequencies. We investigated the two hypotheses in the light of asteroseismology, using our latest tools—including pulsation codes that incorporate star rotation and new generation complete sdB models. The results of both approaches are presented, showing interesting results and raising new questions for our understanding of this mysterious sdB star. [less ▲]

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See detailThe impact of HAART initiation on the selection and persistence of HIV-1 CTL-escape mutations
Dilernia, D.A.; Monaco, D.C.; Jones, L.R. et al

in AIDS Research and Human Retroviruses (2010, October), 26(10), 72

The impact of HAART initiation on the selection and persistence of HIV-1 CTL-escape mutations D.A. Dilernia,1 D.C. Monaco,1 L.R. Jones,2 G.D. Damilano,1 S. Rodriguez,3 H. Salomon1 1Argentinean Reference ... [more ▼]

The impact of HAART initiation on the selection and persistence of HIV-1 CTL-escape mutations D.A. Dilernia,1 D.C. Monaco,1 L.R. Jones,2 G.D. Damilano,1 S. Rodriguez,3 H. Salomon1 1Argentinean Reference Center for AIDS, Capital Federal, Argentina; 2División de Biología Molecular, Estación de Fotobiología, Playa Unión, Rawson, Chubut, Argentina; 3INTA, Castelar, Buenos Aires, Argentina Background: Immune response drives the selection of CTL escape mutations during the course of HIV infection. After initiation of HAART, antiviral drugs exert a strong selective force leading to an important limitation of viral replication. Our objective was to evaluate the impact of HAART initiation on the selection and persistence of CTL-escape mutations. Methods: Blood samples were collected from 113 newly HIV diagnosed individuals. A second sample was collected from 49 of them after 3 years. (12 of which were still drug-naı¨ve in the second sample). Dynamics of CTL-escape mutations identified in the gag gene by statistical analysis of HLA genes and viral sequences, including multiple comparison corrections (BH method) and phylogeny correction (Bayesian MCM method), were analyzed. Epitope-specific immune response was evaluated by ELISPOT against sequence-based designed peptides. Results: Immune response was evaluated on 113 individuals on an HLA-allele basis. Positive responses were detected against 6 of the 9 epitopes containing HLA-associated CTL-escape mutations.A03-restricted epitope RLRPGGKKK had the highest frequency of detection in allele-matched individuals (75%). Epitopes harboring the CTL-escape mutations identified through negative associations (i.e. escape is consensus) had lower frequency of detection: A02-restricted SLYNTVATL(25%) and A24-resctricted KYKLKHIVW(0%). Epitope sequences analysis over the second sample of 21 patients successfully sequenced showed that 38% of them did not have evidence of escape neither in the first sample nor in the second, 44% had the escape mutations in both samples and in 18%the escape mutations appeared in the second sample. Of the 7 individuals containing the epitopes of the last group, only 2 had initiated HAART (28.6%) while 64.3% (9/14) of individuals where no escape emerged, had initiated HAART. Conclusion: Accumulation of CTL-escape mutations at the population-level impaired recognition by individuals studied while initiation of HAART may prevent the selection of new escape mutations even in advanced stages of infection. [less ▲]

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See detailSynovium angiogenesis in osteoarthritis: a new therapy target for chondroitin sulfate
Mathy, Marianne ULg; Lambert, Cécile ULg; Dubuc, Jean Emile et al

in Osteoarthritis and Cartilage (2010, October), 18

Purpose: Osteoarthritis (OA) is an important cause of pain and disability in the ageing population. Angiogenesis and inflammation are closely integrated process in OA and may contribute to its ... [more ▼]

Purpose: Osteoarthritis (OA) is an important cause of pain and disability in the ageing population. Angiogenesis and inflammation are closely integrated process in OA and may contribute to its pathogenesis, as well as, affect disease progression and pain. Chondroitin sulfate (CS) is a symptomatic slow acting drug for OA and there is strong evidence suggesting that CS may also be a structure disease modifying osteoarthritis drug. The mechanisms underlying these effects remain poorly understood. This work aimed to demonstrate the relation between inflammation and angiogenesis of synovium and to study the effect of CS on synovium angiogenesis. [less ▲]

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See detailAdvantages, disadvantages and feasibility of Pay-for-Quality programs in Belgium
Van Herck, Pieter; Sermeus, Walter; Annemans, Lieven et al

in BMC Health Services Research (2010, October), 10

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See detailEXOTIME: searching for planets around pulsating subdwarf B stars
Schuh, Sonja; Silvotti, Roberto; Lutz, Ronny et al

in Astrophysics & Space Science (2010, October), 329

In 2007, a companion with planetary mass was found around the pulsating subdwarf B star V391 Pegasi with the timing method, indicating that a previously undis- covered population of substellar companions ... [more ▼]

In 2007, a companion with planetary mass was found around the pulsating subdwarf B star V391 Pegasi with the timing method, indicating that a previously undis- covered population of substellar companions to apparently single subdwarf B stars might exist. Following this serendip- itous discovery, the EXOTIME (http://www.na.astro.it/ ~silvotti/exotime/) monitoring program has been set up to follow the pulsations of a number of selected rapidly pul- sating subdwarf B stars on time scales of several years with two immediate observational goals: (1) determine P ̇ of the pulsational periods P (2) search for signatures of substellar companions in O– C residuals due to periodic light travel time variations, which would be tracking the central star’s companion- induced wobble around the centre of mass These sets of data should therefore, at the same time, on the one hand be useful to provide extra constraints for classical asteroseismological exercises from the P ̇ (comparison with “local” evolutionary models), and on the other hand allow one to investigate the preceding evolution of a target in terms of possible “binary” evolution by extending the otherwise unsuccessful search for companions to potentially very low masses. While timing pulsations may be an observationally ex- pensive method to search for companions, it samples a dif- ferent range of orbital parameters, inaccessible through or- bital photometric effects or the radial velocity method: the latter favours massive close-in companions, whereas the timing method becomes increasingly more sensitive toward wider separations. In this paper we report on the status of the on-going ob- servations and coherence analysis for two of the currently five targets, revealing very well-behaved pulsational charac- teristics in HS 0444+0458, while showing HS 0702+6043 to be more complex than previously thought. [less ▲]

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See detailAn integrated history of paleoearthquakes along the North Anatolian Fault (Turkey)
Hubert, Aurelia ULg; Vanneste, Kriss; Avsar, U.

in Abstracts with Programs - Geological Society of America (2010, October)

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See detailSedimentological fingerprints of paleoseimic activity revealed from lake sediments: a case study from the North Anatolian Fault (NAF), Turkey
Avsar, Ulas; Hubert, Aurelia ULg; Fagel, Nathalie ULg et al

in Abstracts with Programs - Geological Society of America (2010, October)

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See detailLong-term evolution of the North Anatolian Fault
Hubert, Aurelia ULg; Van Der Woerd, Jerome; King, G. et al

in Abstracts with Programs - Geological Society of America (2010, October)

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See detailEffectiveness of zoledronic acid in the prevention and treatment of glucocorticoid-induced osteoporosis in men and premenopausal women
Saag, k; Roux, C.; Devogelaer, J. P. et al

in Arthritis and Rheumatism (2010, October), 62(10), 902-903

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See detailRelationship between changes in bone mineral density or bone turnover markers and vertebral fracture incidence in patients treated with bazedoxifene
Bruyère, Olivier ULg; Detilleux, Johann ULg; Akadi, Chines et al

in Arthritis and Rheumatism (2010, October), 62(10), 406-407

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See detailLong-term denosumab treatment of postmenopausal women with osteoporosis: results from the first year extension study of the FREEDOM trial
Chapurlat, R.; Papapoulos, Socrates; Bone, Henry G et al

in Arthritis and Rheumatism (2010, October), 62(10), 903

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See detailComparaison de l'évaluation des propriétés de transport tranpéritonéal au moyen d'un dialysat "conventionnel" par rapport à un nouveau dialysat dit "biocompatible"
Van Overmeire, Lionel ULg; Goffin, E.; Bovy, Philippe et al

in Néphrologie & Thérapeutique (2010, September 30), 6

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See detailEvolution nutritionnelle des patients hémodialysés du CHBAH
Meurice, C.; Smelten, Nicole; Furnemont, L. et al

in Néphrologie & Thérapeutique (2010, September 28), (6), 393-394

La dénutrition touche les patients en hémodialyse surtout lorsqu'ils ont plus de 50 ans et plus de 5 ans de dialyse. En 2006, nous avions observé que les patients dialysés (n = 27) ne consommaient pas le ... [more ▼]

La dénutrition touche les patients en hémodialyse surtout lorsqu'ils ont plus de 50 ans et plus de 5 ans de dialyse. En 2006, nous avions observé que les patients dialysés (n = 27) ne consommaient pas le taux de protéines et de calories recommandé. Depuis, nous avons élargi nos régimes. Cette présente étude évalue l'impact de cette nouvelle attitude nutritionnelle chez les anciens (n=11) et les nouveaux patient (n=10). [less ▲]

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See detailCould Western blot analysis be an alternative to radio-immunoassay for sheep pregnancy associated glycoproteins measurements ?
El Amiri, B.; El Abbadi, N.; Benjelloun, B. et al

in Reproduction in Domestic Animals (2010, September 15), 45(Suppl 3), 65

This study prospected whether Western blot analysis could be an alternative to radio-immunoassay (RIA) for sheep pregnancy diagnosis. Blood samples were taken from Boujaâd ewes (n= 9) and Boujaâd x D’man ... [more ▼]

This study prospected whether Western blot analysis could be an alternative to radio-immunoassay (RIA) for sheep pregnancy diagnosis. Blood samples were taken from Boujaâd ewes (n= 9) and Boujaâd x D’man (BD) cross breed (n= 12). The pregnancy associated glycoproeins (PAGs) were weekly monitored in plasma during the whole gestation and the first month postpartum by two RIA systems (El Amiri et al., 2007, Reprod Domest Anim 42:257-62). The highly immunoreactive samples derived from PAG profiles were tested using Western blot based on the same antiserum used in RIA. Each week (from the 13th to the 19th week), two pools of plasma samples (4 ml each) were taken from single and multiple lambing ewes respectively. Samples were submitted to a protein extraction at neutral pH, followed by ammonium sulfate (A.S.) precipitation, dialysis, and lyophilization. The placental extract was used as a check. Results revealed that ewes with multiple lambs presented numerically higher PAG concentrations. In both RIA systems, the high concentrations were recoded around the 19th week of gestation and the maximal concentrations varied from 120 to 700 ng/ml. In Western blot, the placental extracts reacted positively while the plasma samples did not give any positive reaction. In conclusion, the RIA remains the only sensitive method to measure PAGs in plasma. The present study strengthens the need to develop an ELISA kit as an alternative to RIA systems. [less ▲]

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See detailLes conceptions de l'entreprise sociale en Europe et aux Etats-Unis: convergences et divergences
Defourny, Jacques ULg; Nyssens, Marthe

in Revue Internationale de l'Economie Sociale : Recma, Revue des Etudes Coopératives, Mutualistes et Associatives (2010, September 09), 319(janvier 2011), 18-35

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See detailDosage de la 25-OH vitamine D: attention aux erreurs analytiques!
Cavalier, Etienne ULg; Carlisi, Ignazia ULg; Delanaye, Pierre ULg et al

in 27ème Congrès de la Société Française d'Endocrinologie - Deauville, 29 septembre - 2 octobre 2010 (2010, September)

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See detailAn Automata-Based Symbolic Approach for Verifying Programs on Relaxed Memory Models
Linden, Alexander ULg; Wolper, Pierre ULg

in Lecture Notes in Computer Science (2010, September)

This paper addresses the problem of verifying programs for the relaxed memory models implemented in modern processors. Specifically, it considers the TSO (Total Store Order) relaxation, which corresponds ... [more ▼]

This paper addresses the problem of verifying programs for the relaxed memory models implemented in modern processors. Specifically, it considers the TSO (Total Store Order) relaxation, which corresponds to the use of store buffers. The proposed approach proceeds by using finite automata to symbolically represent the possible contents of the store buffers. Store, load and commit operations then correspond to operations on these finite automata. The advantage of this approach is that it operates on (potentially infinite) sets of buffer contents, rather than on individual buffer configurations. This provides a way to tame the explosion of the number of possible buffer configurations, while preserving the full generality of the analysis. It is thus possible to check even designs that exploit the relaxed memory model in unusual ways. An experimental implementation has been used to validate the feasibility of the approach. [less ▲]

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See detailAnti-inflammatory potency of the traditionally used antimalarial plant Fagraea fragrans
Jonville, Marie ULg; Baghdikian, Béatrice; Ollivier, Evelyne et al

in Planta Medica (2010, September), 76(12), 1171

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See detailAntioxidant activity of Passiflora edulis and Passiflora alata fruits
Yariwake, J.; Zeraik, M.; Serteyn, Didier ULg et al

in Planta Medica (2010, September), 76(12), 1274-1275

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See detailBioassay-guided isolation of antiplasmodial Strychnos alkaloids from the stem-bark of Strychnos icaja BAILLON
Tchinda Tiabou, Alembert ULg; Tamze, Victorine; Frederich, Michel ULg et al

in Planta Medica (2010, September), 76(12), 1305

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See detailA Taxonomy of Distinctive Explanatory Business Failure Patterns amongst Small Firms : A Qualitative Approach
Crutzen, Nathalie ULg; Van Caillie, Didier ULg

in Cahier de Recherche du CEPE (2010, September)

Whereas it is obvious that the failure process can vary from one firm to another (Argenti, 1976; D'Aveni, 1989; Laitinen, 1991), to date, few researchers have worked on the detection of several ... [more ▼]

Whereas it is obvious that the failure process can vary from one firm to another (Argenti, 1976; D'Aveni, 1989; Laitinen, 1991), to date, few researchers have worked on the detection of several (explanatory or subsequent) failure patterns. In addition, none of the reviewed research really focuses on small firms while their failure is important and particular (Haswell and Holmes, 1989). Considering these observation and on the basis of an abductive and qualitative analysis (Thiétart, 2003), this paper identifies, among a sample of 208 small distressed firms, a taxonomy of five explanatory business failure patterns, i.e. five homogenous groups of small firms on the basis of the reasons for their failure. As the detection of the fundamental explanatory failure factors is the basis of failure prevention (Argenti, 1976), the identification of these patterns is of crucial importance for a better understanding and for a better prevention of this phenomenon amongst small businesses. [less ▲]

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See detailRelevance of the resident diary method to map odour sources.
Nicolas, Jacques ULg; Cors, Marie; Delva, Julien et al

in Chemical Engineering Transactions (2010, September), 23

A methodology based on the social participation through the use of resident diaries was applied to evaluate the odour annoyance in the surroundings of an industrial park in Belgium during one year. The ... [more ▼]

A methodology based on the social participation through the use of resident diaries was applied to evaluate the odour annoyance in the surroundings of an industrial park in Belgium during one year. The studied area covers about 8 km2 and includes13 potential odour emitting facilities. A network of 44 residents was implied in the survey, from which 19 were particularly considered for a detailed analysis. The questionnaire aimed at providing twice-daily an odour strength rating on a 6-level scale together with an odour qualifier. The fact that the response rate corresponding to "no-odour" was high (79%) is particularly discussed. Some tests are proposed to check the plausibility of the responses, the consistency within clusters of residents and the individual performance of respondents to discriminate among odour ratings. The odour rose is presented as an attractive and visual tool, particularly suited in the case of multi-source areas, to map the different odour emissions, to point out the more worrying ones, some others creating less annoyance and possible new unpredicted ones. The resident diary method proves to be very interesting, especially in the case of an industrial area, provided that validation checks are performed to insure the data reliability. [less ▲]

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See detailLes cibles thérapeutiques pour la PTH dans les nouvelles recommandations du KDIGO: la fin d'un cauchemar?
Cavalier, Etienne ULg; Jean, G.; Delanaye, Pierre ULg et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 424

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See detailFault detection in mechanical systems based on subspace features
Nguyen, Viet Ha ULg; Rutten, Christophe ULg; Golinval, Jean-Claude ULg

in International Conference on Noise and Vibration Engineering (2010, September)

In the field of structural health monitoring or machine condition monitoring, the activation of nonlinear dynamic behavior complicates the procedure of damage or fault detection. Principal Component ... [more ▼]

In the field of structural health monitoring or machine condition monitoring, the activation of nonlinear dynamic behavior complicates the procedure of damage or fault detection. Principal Component Analysis (PCA) is known as an efficient method for damage diagnosis. However, two drawbacks of PCA are the assumption of the linearity of the system and the need of many sensors. This article presents industrial applications of two possible extensions of PCA: Null subspace analysis (NSA) and Kernel PCA (KPCA). The advantages of NSA rely on its rapidity of use and its reliability. The KPCA method, through the use of nonlinear kernel functions, allows to introduce nonlinear dependences between variables. The objective is to address the problem of fault detection in mechanical systems using subspace-based methods. The detection is achieved by comparing the subspace features between the reference and a current state through statistics. Industrial data are used as illustration of the methods. [less ▲]

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See detailMechanical comparison of eight vertical jump exercises
Jidovtseff, Boris ULg; Cronin, John; Harris, Nigel et al

in Computer Methods in Biomechanics & Biomedical Engineering (2010, September), 13(S1), 77-78

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See detailCaractéristiques des prolactinomes résistants aux agonistes dopaminergiques
Vroonen, Laurent ULg; Tamagno, G.; Naves, L. et al

in Annales d'Endocrinologie (2010, September), 71(5), 347

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See detailSCREENIN G AND PREDICTING MALNUTRITION IN lUNG CANCER PATIENTS: DEVELOPING NEW TOOLS.
BARTHELEMY, Nicole ULg; Donneau, Anne-Françoise ULg; Haterte, Stéphanie ULg et al

in Radiotherapy & Oncology (2010, September), 96(supp 1), 378

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See detailEtude de la séquence hyperplasie-adénome dans la tumorigenèse de l'hypophyse : rôle des mutations du gène
Villa, C.; Lagonigro, M.; Magri, F. et al

in Annales d'Endocrinologie (2010, September), 71(5), 411

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See detailEtude génétique et anatomopathologique du syndrome de McCune-Albright chez l'adulte
Beckers, Albert ULg; Burlacu, Maria Cristina ULg; Thiry, Albert ULg et al

in Annales d'Endocrinologie (2010, September), 71(5), 345

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See detailUn nouveau marqueur tumoral pour le carcinome parathyroïdien? Résultats observés chez 24 patients
Cavalier, Etienne ULg; Daly, Adrian ULg; Betea, Daniela ULg et al

in Annales d'Endocrinologie (2010, September), 71(5), 350-351

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See detailLes anticorps hétérophiles : une cause souvent méconnue d'erreurs de diagnostic
Cavalier, Etienne ULg; Carlisi, A.; Delanaye, Pierre ULg et al

in Annales d'Endocrinologie (2010, September), 71(5), 367-68

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See detailConclusions générales sur la journée d'étude consacrée au contrôle juridictionnel de la passation des marchés publics
Durviaux, Ann-Lawrence ULg

in Entreprise et le Droit (L') = Tijdschrift voor Aannemingsrecht (2010, September)

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See detailDioxin levels in European eels, a Belgian study
Focant, Jean-François ULg; Geeraerts, C.; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2010, September)

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See detailDietary intake of PCDD/F and dioxin-like PCB for the Belgian population
Focant, Jean-François ULg; Windal, I.; Vandevijvere, S. et al

in Organohalogen Compounds (2010, September)

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See detailPLE for extraction of dioxins in animal feed and ingredients
Focant, Jean-François ULg; Scholl, Georges ULg; De Pauw, Edwin ULg et al

in Organohalogen Compounds (2010, September), 72

Within the entire complex procedure required to measure dioxins and related compounds in biological matrices, the extraction step is often seen as a well controlled step. Although maybe true for many ... [more ▼]

Within the entire complex procedure required to measure dioxins and related compounds in biological matrices, the extraction step is often seen as a well controlled step. Although maybe true for many human and food-related matrices, the situation is very different for animal feed and feed ingredients. Specific European guidelines (e.g. Commission Directive 2006/13/EC, Commission Regulation (EC) No 152/2009) exist for animal feed but only list general requirements for the various stages of the procedure. The liberty is left to laboratories to select, for example, the tools used for the extraction steps. This has the advantage to allow ‘in-house’ methods to be used, as long as they satisfy with all the requirements of the EU Regulation. In that context, it is foreseen that the European Committee for Standardization (CEN) will soon propose a standard for the determination of PCDD/Fs and PCBs in animal feed that would be the reference method to be used to solve potential issues in case of dispute over results reported from different laboratories. A major point of concern is that it has been reported earlier1 that most commonly accepted extraction procedure can conduct to significantly different results for the extraction of dioxins and related compounds in feed and feed additives such as mineral clays and various oxides. Several non-instrumental and instrumental automated approaches are available for extraction. Soxhlet extractors have long been the most used tools for non-instrumental extraction of solids. They have proven to be very efficient but some limitations encouraged the development of other approaches based on instrumental techniques. For feed extraction, pressurized liquid extraction (PLE) (also branded as accelerated solvent extraction ASE®) is the technique of choice for high sample throughput. This study reports on the investigation of the use of various solvent mixtures, extraction temperatures, and instruments (parallel PLE, sequential ASE®) for the extraction of 17 PCDD/Fs and 12 dioxin-like PCBs in mineral clay, bovine feed, fish meal, and in-house quality control animal compound feed. [less ▲]

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See detailRésistance au traitement par GnRH agonistes dans le cancer de la prostate métastatique
Valdes Socin, Hernan Gonzalo ULg; Waltregny, David ULg; Beckers, Albert ULg

in Annales d'Endocrinologie (2010, September), 71(5), 396

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See detailDosage de la vitamine D : attention aux erreurs analytiques!
Cavalier, Etienne ULg; Carlisi, A.; Delanaye, Pierre ULg et al

in Annales d'Endocrinologie (2010, September), 71(5), 368

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See detailDeux nouvelles mutations dans le gène du récepteur du calcium (CASR) entraînant respectivement une hypo- et une hypercalcémie
Thonnard, Anne-Sophie ULg; Livadariu, Elena ULg; Rydlewski, C. et al

in Annales d'Endocrinologie (2010, September), 71(5), 367

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See detailHypogonadisme congénital chez un homme, associé à une LK immunoréactive normale, élévation de FSH et azoospermie
Valdes Socin, Hernan Gonzalo ULg; Chachati, Anne-Sophie ULg; De Roux, N. et al

in Annales d'Endocrinologie (2010, September), 71(5), 355

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See detailPrévalence et incidence d'épilepsie chez 270 patients avec un traumatisme crânien (TBI) et traités par GH, suivis dans KIMS
Valdes Socin, Hernan Gonzalo ULg; Mattsson, A.; Koltowska-Haggstrom, M. et al

in Annales d'Endocrinologie (2010, September), 71(5), 396

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See detailMutations AIP chez les jeunes patients en dessous de 30 ans avec adénome hypophysaire agressif
Beckers, Albert ULg; Tichomirowa, M.; Barlier, A. et al

in Annales d'Endocrinologie (2010, September), 71(5), 397

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See detailLC-SPE-NMR-MS analysis of Strychnos usambarensis fruits from Rwanda
Cao, Martine ULg; Tits, Monique ULg; Muganga, Raymond et al

in Planta Medica (2010, September), 76(12), 1241-1242

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See detailComparaison d'une méthode "acide" et enzymatique pour le dosage de l'inuline
Thibaudin, L.; Delanaye, Pierre ULg; Maillard, N. et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 316

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See detailLe dosage urinaire et plasmatique du NGAL: étude analytique et implications pratiques pour le clinicien
Cavalier, Etienne ULg; Rozet, Eric ULg; Bekaert, Anne-Catherine ULg et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 350

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See detailEvaluation analytique de la cystatine C: résultats de l'étude multicentrique SN/SFBC
Cavalier, Etienne ULg; Barguil, Y.; Bourgeois, A. M. et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 314

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See detailCytological diagnosis of endometritis in the mare: a comparative study
Daspet, Sarah-Morgane; Ponthier, Jérôme ULg; Jolly, Sandra ULg et al

in Reproduction in Domestic Animals (2010, September), 45s3

It was concluded that the brush swab was a promising diagnostic tool for use in field conditions.

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See detailQuels paramètres cliniques et biologiques peuvent être considérés comme prédictifs des calcifications vasculaires chez le patient hémodialysé?
Delanaye, Pierre ULg; Warling, X.; Moonen, M. et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 296

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See detailPlatelet-Rich Plasma injection to improve tendon healing process
Kaux, Jean-François ULg; Drion, Pierre ULg; Renouf, Julien et al

in Osteoarthritis and Cartilage (2010, September), 18(Supplement 2), 221

Introduction It is well known that injured tendons do not heal easily. For example, tendinopathy is a condition which often becomes chronic in the case of bad or late management. Recently, several studies ... [more ▼]

Introduction It is well known that injured tendons do not heal easily. For example, tendinopathy is a condition which often becomes chronic in the case of bad or late management. Recently, several studies, essentially in vitro and, more recently, a few in clinical practice, have demonstrated the positive effects of platelets on the healing process of different tissues. In fact, platelets contain lots of growth factors which can be released after a local injection. These growth factors have the potentiality to enhance the tendon healing process, for example after rupture or tendinopathy. The aim of our experiment was to ascertain whether the use of Platelet-Rich Plasma (PRP) was of interest for accelerating the healing process of Achilles tendon after surgical induced lesion. Methods All experimental procedures and protocols used in this investigation / were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Liège. 60 rats were divided into 2 groups: A: control (no injection) and B: PRP injection. A 5mm defect was surgically induced in the rats’ Achilles tendon after resection of plantaris tendon. Rats of group B received a PRP injection in situ after the surgery. Afterwards, rats of both groups were placed in their cages without immobilization. After 5, 15 and 30 days, the traumatized Achilles tendons of 10 rats of both groups were removed and dissected during their healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. Rats were then euthanized. Statistical analyses were made with an ANOVA. Values are significant when p-value is below 0.05. Results We observed that the force necessary to induce tendon rupture during biomechanical tensile testing increased with time in both groups; that this force was greater for tendons which had been submitted to an injection of PRP. The ratio between force and weight increased with time in both groups; that this ratio was greater for tendons which had been submitted to an injection of PRP too. There is also a significant interaction between time and the group. The surface area of the section of the tendons increased between 5 and 15 days followed by a stabilization. After 30 days, sections in both groups were similar. Thus, the constraint was similar after 5 and 15 days but is significantly better for PRP group after one month. Discussion – Conclusion We demonstrated that the force necessary to induce tendon rupture during biomechanical tensile testing was greater for tendons which had been submitted to an injection of PRP. These results were observed and significant (p<0.05) from day 5 onwards. We observed too that the section of the tendon was the same in both groups after 30 days. Thus the quality of the healing tendon is better with an injection of PRP, as shown with the increase of the constraint until rupture. Acknowledgement This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants. [less ▲]

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See detailVEGF-111 as a new therapeutic tool for tendon lesion
Kaux, Jean-François ULg; Drion, Pierre ULg; Libertiaux, Vincent ULg et al

in Osteoarthritis and Cartilage (2010, September), 18(Supplement 2), 22

Introduction: Tendon lesion is one of the most frequent pathology in sports and by physical workers. This pathology often becomes chronic. For this reason, it is of interest to develop new treatments ... [more ▼]

Introduction: Tendon lesion is one of the most frequent pathology in sports and by physical workers. This pathology often becomes chronic. For this reason, it is of interest to develop new treatments. Injection of platelet-rich plasma (PRP) seems to be a promising one by releasing growth factors (GF) locally. Among all the GF released by activated platelets, the vascular endothelial growth factor-A (VEGF-A) is known to induce positive effects on vascular function and angiogenesis, and could be implicated in the healing process of tendons. Recently, a novel VEGF-A isoform was identified, the VEGF-111, a biologically active and proteolysis-resistant VEGF-A isoform, also known to present beneficial effects on ischemic diseases. This prompted us to evaluate whether VEFF-111 would have a therapeutic interest within the framework of the tendon pathology. Methods: 60 Rats were divided into 2 groups: A: control (no injection), B: VEGF-111 treatment. A 5mm defect was surgically induced in rat Achilles tendon after resection of plantaris tendon. Rats received a local injection of VEGF-111 (100ng) in situ after the surgery and were placed in their cages without immobilization. After 5, 15 and 30 days, the traumatized Achilles tendons of 10 rats of both groups were removed and dissected during their healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. Rats were then euthanized. Statistical analyses were made with an ANOVA. Values are significant when p-value is below 0.05. Results: Our results shown that the developed force necessary to induce tendon rupture during biomechanical tensile test was greater for tendons which had received an injection of 100ng of VEGF-111. These results were already noticed from day 5 onwards. The ratio between force and weight increased with time in both groups, but this ratio was greater for tendons which had been submitted to an injection of VEGF111. The surface area of the section of the tendons increased between 5 and 15 days followed by a stabilization. After 30 days, sections in both groups were similar. Thus, the constraint was similar after 5 and 15 days but was better for VEGF111 group after one month. Discussion - Conclusion: This experimentation has shown that a 100ng injection of VEGF-111 stimulated tendon healing process as suggested by the increased force needed to break tendons during its healing process and the increased of constraint in comparison with the control group. Other experimentations with different concentration of VEGF111 are now in process. Acknowledgement This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants. [less ▲]

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See detailEtude échocardiographique longitudinale chez des patients atteints de prolactinome et traités par cabergoline
Lancellotti, Patrizio ULg; Latta, K.; O'Connor, Kim ULg et al

in Annales d'Endocrinologie (2010, September), 71(5), 399

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See detailCaractérisation des facteurs associés à la perte d'expression de AIP dans les adénomes hypophysaires somatotropes
Jaffrain-Rea, M. L.; Angelini, M.; Tichomirowa, M. et al

in Annales d'Endocrinologie (2010, September), 71(5), 406

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See detailRecherche de la mutation du gène CDKN1B dans les adénomes hypophysaires familiaux isolés (FIPA): analyse de 86 familles
Beckers, Albert ULg; Tichomirowa, M.; Pellegata, N. et al

in Annales d'Endocrinologie (2010, September), 71(5), 398

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See detailExclusive diffractive Higgs and jet production at the LHC
Royon, Christophe; Staszewski, Rafal; Dechambre, Alice ULg et al

in PoS - Proceedings of Science (2010, August 02), PoS DIS2010(PoS DIS2010), 087

The implementation of exclusive diffractive production of Higgs boson and dijets in the FPMC (Forward Physics Monte Carlo) framework is presented following the models by Khoze, Martin, Ryskin and Cudell ... [more ▼]

The implementation of exclusive diffractive production of Higgs boson and dijets in the FPMC (Forward Physics Monte Carlo) framework is presented following the models by Khoze, Martin, Ryskin and Cudell, Dechambre, Hernandez and Ivanov. The predictions of the models are compared to the CDF measurement of exclusive jets and the uncertainties on the Higgs boson and jet production cross sections at the LHC are discussed. [less ▲]

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See detailUsing a Savart plate in optical metrology
Blain, Pascal ULg; Michel, Fabrice ULg; Renotte, Yvon ULg et al

in Proceedings of SPIE (2010, August), 7791

Non-contact optical measurement methods are essential tools in many industrial and research domains. A family of new non-contact optical measurement methods based on the polarization states splitting ... [more ▼]

Non-contact optical measurement methods are essential tools in many industrial and research domains. A family of new non-contact optical measurement methods based on the polarization states splitting technique and monochromatic light projection as a way to overcome ambient lighting for in-situ measurement has been developed1,2. Recent works3 on a birefringent element, a Savart plate, allow to build a more flexible and robust interferometer. This interferometer is a multipurpose metrological device. On one hand, the interferometer can be set in front of a CCD camera. This optical measurement system is called a shearography interferometer and allows to measure micro displacement between two states of the studied object under coherent lighting. On the other hand, by producing and shifting multiple sinusoidal Young’s interference patterns with this interferometer, and using a CCD camera, it is possible to build a 3D structured light profilometer. After giving the behavior of the Savart plate, an overview of the two devices will be given as well as their specifications and some applications. [less ▲]

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