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See detailCan Autonomous Vehicles Reduce Car Mobility? Evidence from a Stated Adaptation Experiment in Belgium
Cools, Mario ULg; Rongy, Caroline; Limbourg, Sabine ULg

in Transportation Research Board Annual Meeting. Compendium of Papers (2017)

From literature, it is clear that the discussion about the potential benefits and drawbacks of autonomous vehicles is not finished. In order to provide insight into this discussion, this paper ... [more ▼]

From literature, it is clear that the discussion about the potential benefits and drawbacks of autonomous vehicles is not finished. In order to provide insight into this discussion, this paper investigates different attitudes with respect to different key factors for the deployment of system of autonomous taxis. To this end, a stated adaptation experiment was carried out in Belgium in March 2016. To investigate which factors influence the variables of interest, i.e. (i) the number of minutes one is prepared to wait before an autonomous taxi picks up the person, (ii) the ownership of a private car when autonomous taxis are available, (iii) the willigness to share an autonomous taxi, (iv) the permittance for the autonomous vehicle to take a detour when it is beneficial for the society, and (v) the willigness to share your private agenda to ensure a timely autonomous taxi, different regression models are constructed. The results show that the considered explanatory factors only capture a small part of the variability five variables of interest. This is as signal that market segmentation might be very challenging. Besides, this is an indication that a broader range of factors should be included such as life-style factors and psychological constructs. Finally, this acknowledges the need for some skepticism with regard to the potential benefits of autonomous vehicles. The results are interesting for providing realistic boundaries and cross-classification in further simulation studies that look at the benefits of autonomous vehicles. [less ▲]

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See detailAnalyse des conséquences cliniques de la sarcopénie: une revue systématique et méta-analyse.
Beaudart, Charlotte ULg; Zaaria, M.; Pasleau, F. et al

in L'année Gérontologique (2017), 31(1), 18

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See detailRole of nutrition and physical exercise in maintaining intrinsic capacity
Bruyère, Olivier ULg

in Osteoporosis International (2017), 28(S1), 84

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See detailL'étude SarcoPhAge: devenir des sujets sarcopéniques après 2 ans de suivi.
Beaudart, Charlotte ULg; Locquet, Médéa ULg; Reginster, Jean-Yves ULg et al

in L'Année Gérontologique (2017), 31(1), 42

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See detailConnected devices in musculo-skeletal health
Bruyère, Olivier ULg

in Osteoporosis International (2017), 28(S1), 88

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See detailHealth outcomes of sarcopenia: a systematic review and metaanalysis.
Beaudart, Charlotte ULg; Zaaria, M.; Pasleau, Françoise ULg et al

in Osteoporosis International (2017), 28 Suppl 1

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See detailHealth outcomes of sarcopenia: a systematic review and meta-analysis.
Zaaria, M.; Pasleau, Françoise ULg; Reginster, Jean-Yves ULg et al

in Journal of Frailty & Aging (2017), 6 Suppl 1

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See detailSurvey of ESCEO algorithm: methodology and results
Bruyère, Olivier ULg

in Osteoporosis International (2017), 28(S1), 635

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See detailMonitoring Changes in the Volatile Profile of Aging Human Blood
Dubois, Lena ULg; Perrault, Katelynn ULg; Stefanuto, Pierre-Hugues ULg et al

in Forensic Science International (2017), 277

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See detailEnhanced Chemical Profiling of Human Decomposition in a Case Study
Dubois, Lena ULg; Perrault, Katelynn ULg; Stefanuto, Pierre-Hugues ULg et al

in Forensic Science International (2017), 277

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See detailGlobally Induced Forest: A Prepruning Compression Scheme
Begon, Jean-Michel ULg; Joly, Arnaud; Geurts, Pierre ULg

in Proceedings of Machine Learning Research (2017), 70

Tree-based ensemble models are heavy memory- wise. An undesired state of affairs consider- ing nowadays datasets, memory-constrained environment and fitting/prediction times. In this paper, we propose the ... [more ▼]

Tree-based ensemble models are heavy memory- wise. An undesired state of affairs consider- ing nowadays datasets, memory-constrained environment and fitting/prediction times. In this paper, we propose the Globally Induced Forest (GIF) to remedy this problem. GIF is a fast prepruning approach to build lightweight ensembles by iteratively deepening the current forest. It mixes local and global optimizations to produce accurate predictions under memory constraints in reasonable time. We show that the proposed method is more than competitive with standard tree-based ensembles under corresponding constraints, and can sometimes even surpass much larger models. [less ▲]

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See detailÉtude du degré de satisfaction de patients lombalgiques au sujet du site internet éducatif « Retrain Pain »
Demoulin, Christophe ULg; Blanc, A.; Wolfs, Sébastien ULg et al

in Revue du Rhumatisme (2016, December), 83S

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See detailEfficacité d’un programme de rééducation active pluridisciplinaire du dos : suivi de 812 patients lombalgiques chroniques
Mahieu, Geneviève; Boogaerts, M.; Tordeurs, D. et al

in Revue du Rhumatisme (2016, December), 83S

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See detailHost Interleukin 6 and Indoleamine 2,3 Dioxygenase Regulate Inflammation in the Brain during Graft Versus Host Disease
Belle, Ludovic ULg; Koester, E; Hansen, E et al

in Blood (2016, December), 128

Graft versus host disease (GVHD) commonly induces pathological damage in peripheral target organs such as the skin, liver and gastrointestinal tract leading to well characterized organ-specific clinical ... [more ▼]

Graft versus host disease (GVHD) commonly induces pathological damage in peripheral target organs such as the skin, liver and gastrointestinal tract leading to well characterized organ-specific clinical manifestations. A number of studies, however, have shown that patients with GVHD can also have behavioral and mood alterations that can affect overall cognitive function and lead to significant impairments in quality of life. The extent to which GVHD contributes to cognitive dysfunction and induces inflammation within the central nervous system (CNS), however, has not been critically examined. To address this question, we conducted studies using two well-defined murine GVHD models [C57BL/6(H-2b)→Balb/c (H-2d) and B10.BR(H-2k)→B6 (H-2b)]. We observed that there was a significant increase in the number of donor-derived CD4+ and CD8+ T cells in the brains of GVHD recipients early (days 7 -14) and late (day 42) post transplantation compared to BM controls. Histological studies revealed activated microglial cells and CD3+ T cell infiltration in the periventricular regions of brains in GVHD recipients that were not present in BM animals. Real time q-PCR analysis also demonstrated significant increases in IFN-γ, TNF-α, and IL-6 mRNA expression indicative of a proinflammatory state. Notably, GVHD animals exhibited behavioral changes in the forced swim test and elevated plus maze which are validated assays of stress coping and anxiety, respectively. Since IL-6, in particular, plays a pivotal role in GVHD pathogenesis in murine models and humans, we examined whether blockade of IL-6 signaling altered neuroinflammation. Animals treated with an anti-IL-6R antibody had a significant reduction in the number of donor-derived CD4+ and CD8+T cells in the brain compared to isotype control-treated mice. Anti-IL-6R treatment of GVHD mice also resulted in significant reductions in IFN-γ, TNF-α, and IL-6 mRNA and normalized behavior in the forced swim test, indicative of a decreased inflammatory response. Since IL-6 is produced by a wide variety of cells, including microglial and T cells, both donor and recipient cells have the potential to modulate GVHD severity within the CNS. To define whether donor or host IL-6 production was most critical for inducing neuroinflammation, experiments were conducted employing IL-6-/- mice as either donors or recipients. Whereas the absence of IL-6 in donor-derived cells had no impact on the degree of inflammation within the CNS, recipient animals that lacked IL-6 had a significant decrease in the number of donor-derived T cells which accumulated in the brain as well as a marked reduction in inflammatory cytokines, indicating that host IL-6 production was critical. To define the downstream pathways of IL-6-mediated CNS inflammation, we examined the role of indoleamine 2,3-dioxygenase (IDO) since IL-6 has been shown to upregulate IDO-1 expression under inflammatory conditions. We observed that IDO-1 mRNA levels were significantly increased in the brains of GVHD animals, and that blockade of IL-6 signaling resulted in a marked decrease in IDO mRNA levels. Additionally, transplantation studies using IDO-/- mice revealed that host, but not donor, IDO production was required for maximal inflammatory effects. Serotoninergic projections to the prefrontal cortex (PFC), in particular, are sensitive to inflammation and contribute to stress coping behavior. Therefore, to further interrogate this pathway, we performed quantitative mass spectrometry of brain extracts from the PFC. We found that tryptophan and 5HT concentrations were not different between BM and GVHD groups. However, there was an increase in the IDO product, kynurenic acid, in GVHD recipients consistent with an increase in brain IDO expression. To provide additional support for the premise that IL-6 effects were mediated through the IDO pathway, recipient mice were treated with either 1-methyltryptophan (1-MT), a completive inhibitor of IDO, or a vehicle control. GVHD mice treated with 1-MT had decreased accumulation of T cells in the brain and normal behavior in the forced swim test, demonstrating that inhibition of IDO abrogated CNS inflammation and behavioral changes in the presence of intact IL-6 signaling. In summary, these studies demonstrate that host IL-6 and IDO regulate inflammation and adversely impact behavioral function within the brain during GVHD through the tryptophan metabolic pathway. [less ▲]

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See detailSommeil, éveil et cognition au cours du temps
Vandewalle, Gilles ULg

in Bulletin de la Société Royale des Sciences de Liège (2016, November 25)

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See detailIn Vivo Preclinical Molecular Imaging: From the Laboratory Bench to the Patient.
Plenevaux, Alain ULg

in Pharmaceuticals (2016, November 18), 9(4), 73

Preclinical molecular imaging plays a key role in the study of diseases and the development, evaluation, andvalidation of novel treatment and diagnostic techniques. The actual aim is to facilitate the ... [more ▼]

Preclinical molecular imaging plays a key role in the study of diseases and the development, evaluation, andvalidation of novel treatment and diagnostic techniques. The actual aim is to facilitate the translation of innovative therapies and diagnostic agents into patients by providing in vivo proof-of-principle data in animal models of diseases and accordingly match some of the legal requirements before human clinical trials. The real power of preclinical imaging stems from the fact that in vivo data are non-invasively collected, thus making longitudinal studies possible. The evolution of the disease or the actual impact of innovative treatments can be evaluated in the same animal over a long period of time. The major modalities used in preclinical molecular imaging (all present in our laboratory) are the positron emission tomography (microPET), the X-ray tomodensitometry (microCT) and the magnetic resonance imaging (microMRI). The GIGA-CRC In vivo Imaging at ULg is a multidisciplinary laboratory which relies on a medical cyclotron for radioisotope productions, a radiochemistry unit for the development of new radiopharmaceuticals and process automation, a GMP unit for radiopharmaceutical productions, a preclinical imaging unit and a clinical imagingplatform (with MRI, PET, EEG, TMS, . . . ). All expertise and qualified staff are present on site. Our laboratory has all necessary permission and approval for radiopharmaceutical productions and human clinical trials. During this presentation, we will take as an example the development of the first SV2A radioligand [18F]UCB-H (a-b) to illustrate how we can bring new ideas from the laboratory bench to the patient (Bretin, F., et al. Eur. J. Nucl. Med. Mol. Imaging Res. 2013, 3, 35; Warnock, G., et al. J. Nucl. Med. 2014, 55, 1336–1341). [less ▲]

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See detailExcited hyperons of the N = 2 band in the 1/Nc expansion
Stancu, Floarea ULg

in Bled Workshops in Physics (2016, November), 17(1), 25-31

The spectrum of excited baryons in the $N$ = 2 band is reanalyzed in the $1/N_c$ expansion method, with emphasis on hyperons. Predictions are made for the classification of these excited baryons into SU(3 ... [more ▼]

The spectrum of excited baryons in the $N$ = 2 band is reanalyzed in the $1/N_c$ expansion method, with emphasis on hyperons. Predictions are made for the classification of these excited baryons into SU(3) singlets, octets and decuplets. [less ▲]

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See detailEfficient Computation of the Minimum of Shape Quality Measures on Curvilinear Finite Elements
Johnen, Amaury ULg; Geuzaine, Christophe ULg; Toulorge, Thomas et al

in Procedia Engineering (2016, November), 163

We present a method for computing robust shape quality measures defined for any order of finite elements. All type of elements are considered, including pyramids. The measures are defined as the minimum ... [more ▼]

We present a method for computing robust shape quality measures defined for any order of finite elements. All type of elements are considered, including pyramids. The measures are defined as the minimum of the pointwise quality of curved elements. The computation of the minimum, based on previous work presented by Johnen et al. (2013) [1] and [2], is very efficient. The key feature is to expand polynomial quantities into Bézier bases which allows to compute sharp bounds on the minimum of the pointwise quality measures. [less ▲]

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See detailDevices for less invasive surfactant therapy: a manikin study
RIGO, Vincent ULg; Debauche, Christian; Maton, Pierre et al

in European Journal of Pediatrics (2016, November), 175(11), 1756

Background: “Less invasive surfactant therapy” (LIST), or tracheal instillation of surfactant through a small catheter in spontaneously breathing infants, is gaining popularity. Different catheters are ... [more ▼]

Background: “Less invasive surfactant therapy” (LIST), or tracheal instillation of surfactant through a small catheter in spontaneously breathing infants, is gaining popularity. Different catheters are currently used for this purpose: a nasogastric tube inserted with (LISA) or without (Take Care) Magill’s forceps, a 13 cm 16G adult angiocath (MIST), a 30 cm F4 angiography catheter (Stockholm). We developed a specific device by combining a F5 umbilical catheter and an intubation stylet (Liege). We aimed to compare those 5 devices using INSURE as a reference. Methods: 20 neonatologists from 4 institutions supporting different surfactant instillation policies intubated 2 manikin heads with the 5 catheters and an endotracheal tube in a predetermined random sequence. Water was flushed trough the catheter. Video review provided times between laryngoscope (T1) or catheter insertion (T2) in the mouth and water flowing from the trachea. Participants gave an ease of use score (range: 1-9) for each catheter. Results: Procedural times were longer with the Take Care method and shorter with the Liège device (Table). Failure rates were higher for LIST procedures than for INSURE. Take Care and LISA were rated as more difficult, while Liège, Stockholm and INSURE were considered easier. Conclusions: LIST procedures remain difficult, even on a manikin. The choice of catheter is important. A device combining the rigidity of a stylet with the soft distal end of an umbilical catheter is associated with procedures of shorter duration and is considered easier by neonatologists. [less ▲]

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See detailCase report: Ovarian fibroma in a mare – Hormonal considerations
Ponthier, Jérôme ULg; Salciccia, Alexandra ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (2016, October 27), 51(supplement 2), 132

This report shows that, as in humans, AMH as well as steroids productions are low in case of ovarian fibroma, thus preserving normal cyclicity.

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See detailSMART POINT CLOUD: DEFINITION AND REMAINING CHALLENGES
Poux, Florent ULg; Neuville, Romain ULg; Hallot, Pierre ULg et al

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2016, October 05), IV-2(W1), 119-127

Dealing with coloured point cloud acquired from terrestrial laser scanner, this paper identifies remaining challenges for a new data structure: the smart point cloud. This concept arises with the ... [more ▼]

Dealing with coloured point cloud acquired from terrestrial laser scanner, this paper identifies remaining challenges for a new data structure: the smart point cloud. This concept arises with the statement that massive and discretized spatial information from active remote sensing technology is often underused due to data mining limitations. The generalisation of point cloud data associated with the heterogeneity and temporality of such datasets is the main issue regarding structure, segmentation, classification, and interaction for an immediate understanding. We propose to use both point cloud properties and human knowledge through machine learning to rapidly extract pertinent information, using user-centered information (smart data) rather than raw data. A review of feature detection, machine learning frameworks and database systems indexed both for mining queries and data visualisation is studied. Based on existing approaches, we propose a new 3-block flexible framework around device expertise, analytic expertise and domain base reflexion. This contribution serves as the first step for the realisation of a comprehensive smart point cloud data structure [less ▲]

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See detailTowards a normalised 3D Geovisualisation : the viewpoint management
Neuville, Romain ULg; Poux, Florent ULg; Hallot, Pierre ULg et al

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2016, October 05), IV-2(W1), 179-186

This paper deals with the viewpoint management in 3D environments considering an allocentric environment. The recent advances in computer sciences and the growing number of affordable remote sensors lead ... [more ▼]

This paper deals with the viewpoint management in 3D environments considering an allocentric environment. The recent advances in computer sciences and the growing number of affordable remote sensors lead to impressive improvements in the 3D visualisation. Despite some research relating to the analysis of visual variables used in 3D environments, we notice that it lacks a real standardisation of 3D representation rules. In this paper we study the “viewpoint” as being the first considered parameter for a normalised visualisation of 3D data. Unlike in a 2D environment, the viewing direction is not only fixed in a top down direction in 3D. A non-optimal camera location means a poor 3D representation in terms of relayed information. Based on this statement we propose a model based on the analysis of the computational display pixels that determines a viewpoint maximising the relayed information according to one kind of query. We developed an OpenGL prototype working on screen pixels that allows to determine the optimal camera location based on a screen pixels colour algorithm. The viewpoint management constitutes a first step towards a normalised 3D geovisualisation. [less ▲]

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See detailThe OD/OH Isotope Ratio in Comets 8P/Tuttle and C/2012 F6 (Lemmon)
Rousselot, Philippe; Jehin, Emmanuel ULg; Hutsemekers, Damien ULg et al

in Bulletin of the American Astronomical Society (2016, October 01), 48

The determination of isotopic ratios in solar system objects is an important source of information about their origin, especially for comets. Among these ratios the D/H is of particular importance because ... [more ▼]

The determination of isotopic ratios in solar system objects is an important source of information about their origin, especially for comets. Among these ratios the D/H is of particular importance because of its sensitivity to fractionation processes and physical environment, and the abundance of hydrogen in the solar system. The main molecule used to derive this ratio in comets is water. So far, apart water, only HCN has permitted to derive D/H ratio and not only upper limits.Most of the existing determinations of D/H in water molecules have been obtained by spectroscopic observations of water lines in the sub-mm or near infrared range [1,2]. So far only one measurement has been based on OD/OH emission lines radicals in the near-UV [3] and another one on the Lyman-alpha D emission [4]. In situ measurements have also been obtained in comets 1P/Halley and 67P/Churyumov-Gerasimenko using mass spectrometer [5,6,7,8].In this work we have used the OH and OD ultraviolet bands at 310 nm observed with the ESO 8-m Very Large Telescope feeding the Ultraviolet-Visual Echelle Spectrograph (UVES) for measuring the D/H ratio in comets 8P/Tuttle and C/2012 F6 (Lemmon). The OH and OD being the photodissociation products of H[SUB]2[/SUB]O and HDO such observations allow to derive D/H ratio for water molecules. This work constitutes an independant determination of the D/H ratios already published for these comets and based on observations performed in the sub-mm and near infrared range of H[SUB]2[/SUB]O and HDO lines. We present our modeling, data analysis and numerical values obtained for this ratio.[1] D. Bockelée-Morvan et al., 2015, SSR 197, 47-83 [2] N. Biver et al., 2016, A&A 589, id A78, 11p [3] D. Hutsemékers et al., 2008, A&A 490, L31 [4] H.A. Weaver et al., 2008, LPI Contributions 1405, 8216 [5] H. Balsiger, K. Altwegg, J. Geiss, 1995, JGR 100, 5827 [6] P. Eberhardt et al., 1995, A&A 302, 301 [7] R.H. Brown et al., 2012, PSS 60, 166 [8] K. Alwegg et al., 2015, Science 347, article id. 1261952 [less ▲]

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See detailSurvey for Ortho-to-Para Abundance Ratios (OPRs) of NH2 in Comets: Revisit to the Meaning of OPRs of Cometary Volatiles
Kawakita, Hideyo; Shinnaka, Yoshiharu; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2016, October 01), 48

Since molecules having identical protons can be classified into nuclear-spin isomers (e.g., ortho-H[SUB]2[/SUB]O and para-H[SUB]2[/SUB]O for water) and their inter-conversions by radiative and non ... [more ▼]

Since molecules having identical protons can be classified into nuclear-spin isomers (e.g., ortho-H[SUB]2[/SUB]O and para-H[SUB]2[/SUB]O for water) and their inter-conversions by radiative and non-destructive collisional processes are believed to be very slow, the ortho-to-para abundance ratios (OPRs) of cometary volatiles such as H[SUB]2[/SUB]O, NH[SUB]3[/SUB] and CH[SUB]4[/SUB] in coma have been considered as primordial characters of cometary molecules [1]. Those ratios are usually interpreted as nuclear-spin temperatures although the real meaning of OPRs is in strong debate. Recent progress in laboratory studies about nuclear-spin conversion in gas- and solid-phases [2,3] revealed short-time nuclear-spin conversions for water, and we have to reconsider the interpretation for observed OPRs of cometary volatiles. We have already performed the survey for OPRs of NH[SUB]2[/SUB] in more than 20 comets by large aperture telescopes with high-resolution spectrographs (UVES/VLT, HDS/Subaru, etc.) in the optical wavelength region [4]. The observed OPRs of ammonia estimated from OPRs of NH[SUB]2[/SUB], cluster around ~1.1 (cf. 1.0 as a high-temperature limit), indicative of ~30 K as nuclear-spin temperatures. We present our latest results for OPRs of cometary NH[SUB]2[/SUB] and discuss about the real meaning of OPRs of cometary ammonia, in relation to OPRs of water in cometary coma. Chemical processes in the inner coma may play an important role to achieve un-equilibrated OPRs of cometary volatiles in coma.This work was financially supported by MEXT Supported Program for the Strategic Research Foundation at Private Universities, 2014–2018 (No. S1411028) (HK) and by Graint-in-Aid for JSPS Fellows, 15J10864 (YS).References:[1] Mumma & Charnley, 2011, Annu. Rev. Astro. Astrophys. 49, 471.[2] Hama & Watanabe, 2013, Chem. Rev. 113, 8783.[3] Hama et al., 2008, Science 351, 6268.[4] Shinnaka et al., 2011, ApJ 729, 81. [less ▲]

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See detailOstéoblastes autologues (PREOB®) versus concentré de moelle autologue dans l’ostéonécrose de la tête fémorale : étude randomisée
HAUZEUR, Jean-Philippe ULg; Tungouz, Michel; LECHANTEUR, Chantal ULg et al

in Revue de Chirurgie Orthopédique et Traumatologie (2016, October), 102

In non-traumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow concentrate (BMC) containing mesenchymal stem cells (MSC) could delay ONFH progression and improve symptoms (Hernigou ... [more ▼]

In non-traumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow concentrate (BMC) containing mesenchymal stem cells (MSC) could delay ONFH progression and improve symptoms (Hernigou 2002, Gangji 2004). The next step was to assess the hypothesis that a population of autologous osteoblastic cells (OB) consisting in a more differentiated cell than MSC, could be more efficacious than BMC in early stages ON. [less ▲]

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See detailWhat are the optimal walking tests to assess disability progression?
Pierard, Sébastien ULg; Van Droogenbroeck, Marc ULg

in Multiple Sclerosis Journal (2016, September 16), 22(S3), 452-453

Background. Therapy success is assumed when there is no evidence of disease activity. Clues to show it include an MRI, the relapses history, questionnaires, and clinical measures to assess the disability ... [more ▼]

Background. Therapy success is assumed when there is no evidence of disease activity. Clues to show it include an MRI, the relapses history, questionnaires, and clinical measures to assess the disability progression. Especially gait analysis plays a major role as gait impairment is considered by patients as the most disabling symptom. Too often only the walking speed is measured. New technologies (eg GAIMS, see ECTRIMS 2012-15) measure many spatiotemporal gait parameters, even during long tests (\eg 6min, 500m), without equipping patients with markers or sensors. Moreover, various tests can be done, depending on the length and type of walk (comfortable pace --C--, as fast as possible --F--, tandem gait --T--). Objective. Determine if there is an advantage to perform various walking tests, and which test or combination of tests brings the higher amount of information about the patient state in a reasonable amount of acquisition time. Methods. The system GAIMS provided 434 recordings of the gait parameters of healthy people and 60 recordings of MS patients with EDSS<= 4. They performed 12 tests (25ft C+F+T each twice, 20m C+F+T, 100m C+F, 500m F). To assess the ability of these clinical outcome measures to detect disability progression, we evaluate the possibility of differentiating the persons below a given EDSS threshold (0.25) from those above it based only on the measured gait parameters. For individual tests, we use the classifier of Azrour (ESANN 2014). All subsets of the tests are also considered, by combining the individual classifiers and determining automatically the optimal relative importance of the tests with the linear support vector machine (SVM) technique. The ability to detect the disability progression is quantified by the performance (area under the ROC curve --AUC-- and the maximum achievable balanced accuracy --MBA--) of the corresponding classifiers. Results. The best test alone is the 500m F (note that the walking speed measured during it is the gait parameter best correlated with the EDSS). Combining several tests leads to a better performance. A performance (MBA=95.7%, AUC=0.983) close to the best achievable one can be obtained with 6 tests only (25ft C twice, 25tf F twice, 20m C, 20m T). Conclusions. The clinical gait analysis can help to detect disability progression. While considering different types of walking tests improves the ability of taking decisions, we showed that performing 6 tests for a total of 70.48m suffices. [less ▲]

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See detailModels of rotating stars constrained by asteroseismic measurements of red giants
Eggenberger, P.; Lagarde, N.; Miglio, A. et al

in Astronomische Nachrichten (2016, September 01), 337(8-9), 832-836

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and ... [more ▼]

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and internal properties of these stars. In particular, core rotation rates have been obtained for red-giant stars, which is of prime importance to progress in the modelling of the dynamical processes at work in stellar interiors. In this presentation, we discuss which constraints can be brought by these asteroseismic measurements on stellar models that include rotational effects. Similarly to the solar case, we show that an efficient mechanism is required for the transport of angular momentum in the radiative zones of red giants. The efficiency of this transport process can be determined by asteroseismic observations of red-giant stars. [less ▲]

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See detailValeurs de référence de débit de filtration glomérulaire en population noire-africaine
Yayo, E; Monnet, D; Attoungbré, M.-L. et al

in Néphrologie & Thérapeutique (2016, September), 12(5), 273

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See detailGait pattern of healthy old people for fast walking condition
GILLAIN, Sophie ULg; Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg et al

in Gerontechnology (2016, September)

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See detailAge-related changes in the modulation of attentional brain responses to sleep pressure at night
Schmidt, Christina ULg; Reichert, Carolin; Maire, Micheline et al

in Journal of Sleep Research (2016, September)

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See detailGait pattern of healthy old people for dual task walking condition
GILLAIN, Sophie ULg; Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg et al

in Gerontechnology (2016, September)

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See detailHome blood pressure in kidney transplant recipients (Ktr) - Validity of different schedules of self-monitoring
SAINT-REMY, Annie ULg; WEEKERS, Laurent ULg; BONVOISIN, Catherine ULg et al

in Journal of Hypertension (2016, September), 34(e supplement 2), 119

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See detailCompte rendu de l’atelier « Entretiens de stages »
Francois, Nathalie ULg; Simons, Germain ULg; Van Hoof, Florence ULg

in Didactiques en Pratique (2016, September), 2

Cet article présente le compte rendu d'un atelier portant sur les entretiens de stages dans l'enseignement. Lors de l'atelier, les participants étaient invités à analyser des extraits d'entretiens entre ... [more ▼]

Cet article présente le compte rendu d'un atelier portant sur les entretiens de stages dans l'enseignement. Lors de l'atelier, les participants étaient invités à analyser des extraits d'entretiens entre un futur enseignant, son maitre de stage et son formateur. La discussion collective a permis ensuite de mettre en exergue des éléments potentiellement porteurs et facilitateurs dans ces situations d'entretiens. [less ▲]

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See detailUniversité d'été du Cifen 2015 : insertion professionnelle et parcours enseignants. Mise en perspective et présentation du programme de la journée
Simons, Germain ULg

in Didactiques en Pratique (2016, September), 2

Cette communication ouvrait l'Université d'été 2015 du Cifen. La thématique du colloque : "insertion professionnelle et parcours enseignants" y fut brièvement présentée, de même que les questions qui ... [more ▼]

Cette communication ouvrait l'Université d'été 2015 du Cifen. La thématique du colloque : "insertion professionnelle et parcours enseignants" y fut brièvement présentée, de même que les questions qui allaient baliser cette journée d'études. Ensuite le programme de la journée fut rappelé aux participants. [less ▲]

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See detailSystematic Downstream Development, Optimization and Equipment Design for Biobased Products and Processes
Bednarz, Andreas; Rüngeler, Bettina; Scherübel, Peter et al

in Chemie Ingenieur Technik (2016, September), 88(9), 1375-1376

Biobased synthesis poses specific challenges due to the properties of raw materials, intermediates, and products. They are induced by the higher oxygen content as compared to fossil feedstock. Thus low ... [more ▼]

Biobased synthesis poses specific challenges due to the properties of raw materials, intermediates, and products. They are induced by the higher oxygen content as compared to fossil feedstock. Thus low vapor pressure, higher viscosity, low concentration in aqueous solution will require new, preferably liquid-based downstream processes, for which many different options can be proposed. A systematic method to evaluate such a multitude of options based on cascaded option trees is presented, which combines representation and evaluation of options on a suitably chosen level of detail. Criteria, which have to be fulfilled by the options, are flexibly evaluated ranging from input of experts to detailed simulation. Clear visualization also allows transparent communication of results to members of interdisciplinary teams and project partners. The method is demonstrated for extractive separation steps including real-world problems encountered. This includes high viscosities, presence of solids or microorganisms leading to crud formation, and optimization of process conditions solving the conflicting challenges balancing e.g. between low toxicity to microorganisms and process efficiency. [less ▲]

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See detailApproche stratégique de formation du personnel local au sein des ONG internationales dans un contexte incertain : cas du Burundi
Hakizumukama, Alexis ULg

in Actes des Rencontres Internationales sur la Diversité (2016, September)

The human resources management issues is a major challenge for the current and future international organizations, especially those of the non merchant sector, as the environmental context in which they ... [more ▼]

The human resources management issues is a major challenge for the current and future international organizations, especially those of the non merchant sector, as the environmental context in which they operate is changing more and more quickly. Thus, beyond the mobilization and the gradual professionalization of volunteers to adapt their contribution to the missions of NGOs, these organizations are also experiencing a real need for personnel able to adapt without too much difficulty, the complexity of the local context whose evolution often proves unpredictable. But this labor, multiple and high skills, is often scarce on the local labor market. This finding essentially explains the presence of expatriates who work daily alongside local employees who may be employees and volunteers, and whose management requires a sufficiently coherent strategy with organizational goals and interests of these stakeholders. HRM strategy implementation within the subsidiaries shall submit their leaders to multiple challenges brought by a set of actors focused on different and even divergent interests. The model and HRM practices in any organization, reflect the dominant HRM strategy. During our research, we pay special attention to the evolution of HRM models (Pichault and Nizet, 2013) and strategy implemented in the training of local personnel by subsidiaries studied by relying on the theory of social regulation (Reynaud, 1997, 1999). The conclusions of our work indicate that the development of HRM strategy following a joint regulatory process appears best suited to international NGOs working in uncertain environment. [less ▲]

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See detailSatellite Formation Control Using Continuous Adaptive Sliding Mode Controller
Cho, Hancheol ULg; Kerschen, Gaëtan ULg

in AIAA/AAS Astrodynamics Specialist Conference (2016, September)

The focus of this study is on the development of a robust controller with a simple gain adaptation for satellite formation control. The complete nonlinear dynamics of the motion of the follower satellite ... [more ▼]

The focus of this study is on the development of a robust controller with a simple gain adaptation for satellite formation control. The complete nonlinear dynamics of the motion of the follower satellite relative to the leader satellite is considered and the rigorous proof for the stability of the controlled formation system is given in the presence of unknown external disturbances and unknown mass of the follower satellite. Although the controller design is based on the concept of sliding mode control, the proposed control strategy is free from chattering and guarantees a finite-time convergence of the controlled system to the target area. Furthermore, a simple adaptive law to automatically update the control gain is suggested that does not require a priori knowledge of the uncertainties of the system. In addition, to guarantee the robustness from the beginning and to improve the transient performance, a new sliding surface is also constructed. Numerical simulations are carried out to demonstrate the effectiveness of the proposed adaptive controller to maintain a desired formation configuration by compensating for the initial offset errors and external disturbance effects including gravitational perturbations and atmospheric drag. [less ▲]

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See detailWhen to use locking implants?
Balligand, Marc ULg

in Proceedings of the 18th ESVOT congress (2016, September)

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See detailLocking implants : polyaxial systems
Balligand, Marc ULg

in Proceedings of the 18th congress 2016 (2016, September)

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See detailSetting up ex-vivo biomechanics studies
Balligand, Marc ULg

in Proceedings of the 18th ESVOT congress (2016, September)

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See detailComparative analysis of the respiratory microbiota of healthy dogs and dogs with canine idiopathic pulmonary fibrosis
Roels, Elodie ULg; Taminiau, Bernard ULg; Darnis, Elodie ULg et al

in Journal of Veterinary Internal Medicine (2016, September)

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See detailEVALUATION OF FISH EXPOSURE TO POP-LIKE (ORGANOTIN) COMPOUNDS IN SEPETIBA BAY (RIO DE JANEIRO STATE, BRAZIL) THROUGH HEPATIC TOTAL TIN CONCENTRATIONS
Paiva, TC; Schilithz, PF; Bisi, TL et al

in Organohalogen Compounds (2016, August)

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See detailEVALUATING THE CHEMICAL SAFETY OF EDIBLE INSECTS
Poma, G; Cuykx, M; Amato, E et al

in Organohalogen Compounds (2016, August), 78

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See detailREVISITED SAMPLE PREPARATION APPROACH FOR DIOXIN MEASUREMENTS IN HUMAN SERUM SAMPLES
Calaprice, Chiara ULg; Focant, Jean-François ULg

in Organohalogen Compounds (2016, August), 78

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See detailInvolvement of membrane remodelling induced by fatty acids in the regulation of the NLRP3 inflammasome activity in human macrophages
Gianfrancesco, Marco ULg; Dehairs, Jonas; Bloch, Katarzyna et al

in Diabetologia (2016, August), 59(Supplement 1), 291

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See detailModel-Based Decision Support Algorithm to Guide Fluid Resuscitation
Pironet, Antoine ULg; Dauby, Pierre ULg; MORIMONT, Philippe ULg et al

in IFAC-PapersOnLine (2016, July 26), 49(5), 224-229

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See detailDistinct cerebral metabolic patterns related to high pain sensitivity in episodic or chronic migraine patients and healthy volunteers
D'Ostilio, Kevin ULg; Lisicki Martinez, Marco ULg; Schoenen, Jean ULg et al

in Frontiers in Aging Neuroscience (2016, July)

Introduction Allodynia, i.e. pain evoked by a non-painful stimulus, is prevalent in chronic pain and in migraine where it augments with disease severity and chronicity [1]. Central sensitization is ... [more ▼]

Introduction Allodynia, i.e. pain evoked by a non-painful stimulus, is prevalent in chronic pain and in migraine where it augments with disease severity and chronicity [1]. Central sensitization is thought to be the culprit [2]. It is not known, however, which central areas are involved. The aim of the present study was to evaluate whether brain metabolism in subjects that are more sensitive to pain is different between migraine patients and healthy controls. Subjects and methods Quantitative heat sensory testing on the forehead and 18FDG-PET were performed in 55 subjects: 20 healthy volunteers (HV, 21-59 years, 5M), 21 patients with episodic migraine in the interictal phase (MO, age range: 20-63 years, 5M) and 14 patients with chronic migraine (CM, age range: 22-62 years, 1M). The 3 cohorts were subdivided according to the median heat pain threshold into subgroups with low and high pain thresholds. PET results were compared between these subgroups in each cohort. Data analyses were restricted to areas of the pain/salience matrix. Results There was no significant difference in heat pain thresholds between HV (median: 43.7 °C), MO median: 44.2°C) and CM (median: 43.3°C) (p=0.64). In an SPM-ANOVA, a contrast modelling the potential gradual effect of increased differences in pain sensitivity in relation to disease severity showed significant metabolic changes in bilateral thalamus and midbrain (p < 0.001). Additional analyses revealed that hypometabolic areas in subgroups with a low heat pain threshold differed between HV (anterior cingulate and somatosensory cortices), MO (lower pons and somatosensory cortex) and CM (midbrain and thalamus) (Figure 1). Conclusion Overall migraine patients do not have reduced heat pain thresholds. However, hypometabolic areas related to high thermal pain sensitivity are strictly cortical in HV, but comprise the pons in episodic migraine and are restricted to midbrain and thalamus in chronic migraine. The distinct central correlates of heat pain sensitivity in migraine patients might therefore represent a biomarker of migraine and its chronification. Legend to figure Figure 1. Hypometabolic areas in low pain threshold subgroups in HV (green), MO (orange) and CM (red). p < 0.01 for display purpose. Résumé en Français: Titre: Métabolisme cérébral distinct en relation avec la sensibilité à la douleur entre sujets sains, migraine épisodique et migraine chronique. Les migraineux ont une sensibilité anormale à la douleur. Les mécanismes cérébraux en sont inconnus. Nous avons comparé le métabolisme cérébral chez des sujets sains et chez des migraineux épisodiques ou chroniques et correlé les résultats avec le seuil douloureux. Les aires cérébrales hypométaboliques liées à un seuil douloureux bas diffèrent entre groupes: régions corticales chez les sujets sains, aires corticales et sous-corticales dans la migraine épisodique, régions sous-corticales dans la migraine chronique .Le contrôle central de la douleur semble modifié distinctement dans les formes de migraine, ce qui pourrait en constituer un biomarqueur et avoir des implications thérapeutiques. [less ▲]

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See detailNew antimalarial compounds isolated from Poupartia borbonica, a Mascarene Islands endemic plant
Ledoux, Allison ULg; Jansen, Olivia ULg; St-Gelais, Alexis et al

in Planta Medica (2016, July), 82(S01), 1-381

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See detailThe shadow position sensors (SPS) formation flying metrology subsystem for the ESA PROBA-3 mission: Present status and future developments
Focardi, Mauro; Thizy, Cédric ULg; Renotte, Etienne ULg

in Proceedings of SPIE (2016, June)

PROBA-3 [1] [2] is a Mission of the European Space Agency (ESA) composed of two formation-flying satellites, planned for their joint launch by the end of 2018. Its main purposes have a dual nature ... [more ▼]

PROBA-3 [1] [2] is a Mission of the European Space Agency (ESA) composed of two formation-flying satellites, planned for their joint launch by the end of 2018. Its main purposes have a dual nature: scientific and technological. In particular, it is designed to observe and study the inner part of the visible solar corona, thanks to a dedicated coronagraph called ASPIICS (Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun), and to demonstrate the in-orbit formation flying (FF) and attitude control capability of its two satellites. The Coronagraph payload on-board PROBA-3 consists of the following parts: the Coronagraph Instrument (CI) with the Shadow Position Sensor (SPS) on the Coronagraph Spacecraft (CSC), the Occulter Position Sensor (OPSE) [3] [4] and the External Occulting (EO) disk on the Occulter Spacecraft (OSC). The SPS subsystem [5] is one of the main metrological devices of the Mission, adopted to control and to maintain the relative (i.e. between the two satellites) and absolute (i.e. with respect to the Sun) FF attitude. It is composed of eight micro arrays of silicon photomultipliers (SiPMs) [6] that shall be able to measure, with the required sensitivity and dynamic range as asked by ESA, the penumbral light intensity on the Coronagraph entrance pupil. With the present paper we describe the testing activities on the SPS breadboard (BB) and Development Model (DM) as well as the present status and future developments of this PROBA-3 metrological subsystem. [less ▲]

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See detailPreliminary evaluation of the diffraction behind the PROBA 3/ASPIICS optimized occulter
Baccani, Cristian; Thizy, Cédric ULg; Renotte, Etienne ULg

in Proceedings of SPIE (2016, June)

ROBA-3 is a technological mission of the European Space Agency (ESA), devoted to the in-orbit demon- stration of formation flying (FF) techniques and technologies. ASPIICS is an externally occulted ... [more ▼]

ROBA-3 is a technological mission of the European Space Agency (ESA), devoted to the in-orbit demon- stration of formation flying (FF) techniques and technologies. ASPIICS is an externally occulted coronagraph approved by ESA as payload in the framework of the PROBA-3 mission and is currently in its C/D phase. FF offers a solution to investigate the solar corona close the solar limb using a two-component space system: The external occulter on one spacecraft and the optical instrument on the other, separated by a large distance and kept in strict alignment. ASPIICS is characterized by an inter-satellite distance of â1/4144 m and an external occulter diameter of 1.42 m. The stray light due to the diffraction by the external occulter edge is always the most critical offender to a coronagraph performance: The designer work is focused on reducing the stray light and carefully evaluating the residuals. In order to match this goal, external occulters are usually characterized by an optimized shape along the optical axis. Part of the stray light evaluation process is based on the diffraction calculation with the optimized occulter and with the whole solar disk as a source. We used the field tracing software VirtualLabTM Fusion by Wyrowski Photonics [1] to simulate the diffraction. As a first approach and in order to evaluate the software, we simulated linear occulters, through as portions of the flight occulter, in order to make a direct comparison with the Phase-A measurements [2]. [less ▲]

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See detailALERBLOT: Interest of 2D Immunoblot for the diagnosis of allergy to wheat
BERTHOLET, Catherine ULg; GADISSEUR, Romy ULg; quinting, birgit et al

in Allergy (2016, June), 71

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See detailVUV Optical Ground System Equipment and its application to the ICON FUV flight grating characterization and selection
Blain, Pascal ULg; Desselle, Richard ULg; Domken, Isabelle ULg et al

in Advances in Optical and Mechanical Technologies for Telescopes and Instrumentation (2016, June)

ICON FUV is a two channel spectrographic imager that measures intensity and spatial distribution of oxygen (135.6 nm) and molecular nitrogen (157 nm) of the ionosphere. As those wavelengths are strongly ... [more ▼]

ICON FUV is a two channel spectrographic imager that measures intensity and spatial distribution of oxygen (135.6 nm) and molecular nitrogen (157 nm) of the ionosphere. As those wavelengths are strongly absorbed by the atmosphere, the optical elements of the system have to be tested inside vacuum chambers. Prior to the instrument alignment and calibration, two 3600 gr/mm gratings were characterized. The primary focus is the measurement of the diffraction efficiencies; while the second objective is to select the best grating and to define which is the flight and the spare. A dedicated setup has been developed to assess the grating optical performances under vacuum. A 1 cm diameter collimated beam is generated using an off-axis parabola and a UV source at its focal point. The grating is placed at the center of two rotation stages collinearly aligned. One detector is placed on a rotating arm, deported from its rotation center. A PMT detector records diffracted light intensity with respect to its angular position and its wavelength. Angular incidence on the grating is tuned with the help of the second rotation stage. The grating efficiency homogeneity and scattering properties are measured through a Y-X scan. [less ▲]

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See detailDe Reinach à Levinas : Hering et le réalisme phénoménologique
Boccaccini, Federico ULg

in Revue de théologie et de Philosophie (2016, June)

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See detailInstauration d'un trajet de réintégration multidisciplinaire au sein de l'Assurance Maladie belge : ombres et lumière
Mairiaux, Philippe ULg

in Archives des Maladies Professionnelles et de l'Environnement (2016, June), 77(3), 363

Le modèle dit de Sherbrooke développé par P. Loisel au Québec constitue le fondement des recommandations internationales en matière de programmes de retour au travail pour les travailleurs souffrant de ... [more ▼]

Le modèle dit de Sherbrooke développé par P. Loisel au Québec constitue le fondement des recommandations internationales en matière de programmes de retour au travail pour les travailleurs souffrant de lombalgie. Ce modèle a inspiré les recommandations belges et françaises (HAS 2013) en la matière. De nombreuses études explorent maintenant la possibilité d’une intervention précoce en milieu de travail – un des axes essentiels du modèle de Sherbrooke - dans d’autres problématiques de santé que la lombalgie, et notamment en cas de décompensation psychique. La combinaison d’une telle intervention avec les approches propres aux milieux de soin représente cependant un réel défi. Le programme de prévention secondaire de la lombalgie initié en Belgique en 2004 dans le cadre de l’assurance maladies professionnelles permet d’illustrer quelques-unes des difficultés à surmonter : information du public-cible (tout travailleur exposé à la manutention de charges et/ou aux vibrations corps-entier) et des médecins traitants concernés, mise en place d’une collaboration, jusque-là inexistante, entre médecins de revalidation et médecins du travail, sensibilisation des employeurs. Même la collaboration entre médecins se heurte à de sérieuses barrières. Elle implique en effet un dialogue et une relation de confiance entre le médecin traitant qui considère prioritairement la protection de son patient, le médecin du travail qui a à juger l’aptitude d’un travailleur pour une activité de travail définie et un médecin-conseil de la sécurité sociale dont la fonction centrale était encore récemment le contrôle du bien-fondé de l’arrêt de travail afin de préserver l’équilibre financier du système. La prévention de la désinsertion professionnelle devrait idéalement constituer un objectif commun à ces trois métiers médicaux mais il s’agit à l’évidence d’un chantier de longue haleine. La décision du gouvernement belge d’instaurer un trajet de réintégration multidisciplinaire au sein de l'Assurance Maladie pour tout assuré en arrêt-maladie depuis 3 mois a révélé, avant même sa mise en application prévue en 2016, les enjeux sous-jacents à un tel projet. Les négociations avec les partenaires sociaux ont abordé plusieurs questions. Veut-on promouvoir plus d’équité sociale, ou simplement limiter l’augmentation alarmante des dépenses d’invalidité ? L’entrée de l’assuré dans le trajet proposé va-t-elle se faire sur base volontaire, ou faut-il prévoir une sanction financière en cas de refus ? A quel médecin confier la direction du trajet ? Quelle place réserver au médecin du travail, et au médecin traitant ? Faut-il prévoir une responsabilisation financière de l’entreprise ou faire confiance à la bonne volonté des employeurs ? [less ▲]

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See detailEffect of chondroitin sulfate on soluble biomarkers of osteoarthritis: how to analyze and interpret the results from an open-label trial in unilateral knee osteoarthritis patients
Möller, I; Gharbi, Myriam; Martinez, H et al

in Annals of the Rheumatic Diseases (2016, June), 75(Suppl 2), 1167

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See detailAlignment and calibration of the ICON-FUV instrument: Development of a vacuum UV facility
Loicq, Jerôme ULg; Blain, Pascal ULg; Kintziger, Christian ULg et al

in Proceedings of SPIE (2016, June)

The optical calibration of the ICON-FUV instrument requires designing specific ground support equipment (GSE). The ICON-FUV instrument is a spectrographic imager that operates on two specific wavelengths ... [more ▼]

The optical calibration of the ICON-FUV instrument requires designing specific ground support equipment (GSE). The ICON-FUV instrument is a spectrographic imager that operates on two specific wavelengths in the UV (135.6 nm and 157 nm). All the operations have to be performed under vacuum UV light. The optical setup is based on a VUV monochromator coupled with a collimator that illuminates the FUV entrance slit. The instrument is placed on a manipulator providing fields pointing. Image quality and spectral properties can be then characterized for each field. OGSE, MGSE, optical calibration plan and vacuum alignment of the instrument are described. [less ▲]

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See detailOptical design and optical properties of a VUV spectrographic imager for ICON mission
Loicq, Jerôme ULg; Kintziger, Christian ULg; Mazzoli, Alexandra ULg et al

in Proceedings of SPIE (2016, June)

In the frame of the ICON (Ionospheric Connection Explorer) mission of NASA led by UC Berkeley, CSL and SSL Berkeley have designed in cooperation a new Far UV spectro-imager. The instrument is based on a ... [more ▼]

In the frame of the ICON (Ionospheric Connection Explorer) mission of NASA led by UC Berkeley, CSL and SSL Berkeley have designed in cooperation a new Far UV spectro-imager. The instrument is based on a Czerny-Turner spectrograph coupled with two back imagers. The whole field of view covers [± 12° vertical, ± 9° horizontal]. The instrument is surmounted by a rotating mirror to adjust the horizontal field of view pointing by ± 30°. To meet the scientific imaging and spectral requirements the instrument has been optimized. The optimization philosophy and related analysis are presented in the present paper. PSF, distortion map and spectral properties are described. A tolerance study and alignment cases were performed to prove the instrument can be built and aligned. Finally straylight and out of band properties are discussed. [less ▲]

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See detailRecent achievements on ASPIICS, an externally occulted coronagraph for PROBA-3.
Renotte, Etienne ULg; Denis, François ULg; Desselle, Richard ULg et al

in Proceedings of SPIE (2016, June)

This paper presents the current status of ASPIICS, a solar coronagraph that is the primary payload of ESA’s formation flying in-orbit demonstration mission PROBA-3. The “sonic region” of the Sun corona ... [more ▼]

This paper presents the current status of ASPIICS, a solar coronagraph that is the primary payload of ESA’s formation flying in-orbit demonstration mission PROBA-3. The “sonic region” of the Sun corona remains extremely difficult to observe with spatial resolution and sensitivity sufficient to understand the fine scale phenomena that govern the quiescent solar corona, as well as phenomena that lead to coronal mass ejections (CMEs), which influence space weather. Improvement on this front requires eclipse-like conditions over long observation times. The space-borne coronagraphs flown so far provided a continuous coverage of the external parts of the corona but their over-occulting system did not permit to analyse the part of the white-light corona where the main coronal mass is concentrated. The PROBA-3 Coronagraph System, also known as ASPIICS (Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun) is designed as a classical externally occulted Lyot coronagraph but it takes advantage of the opportunity to place the external occulter on a companion spacecraft, about 150m apart, to perform high resolution imaging of the inner corona of the Sun as close as ~1.1 solar radii. The images will be tiled and compressed on board in an FPGA before being down-linked to ground for scientific analyses. ASPIICS is built by a large European consortium including about 20 partners from 7 countries under the auspices of the European Space Agency. This paper is reviewing the recent development status of the ASPIICS instrument as it is approaching CDR. [less ▲]

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See detailThe satellite formation flying in lab: PROBA-3/ASPIICS metrology
Capobianco, G; Thizy, Cédric ULg; Renotte, Etienne ULg

in Proceedings of SPIE (2016, June)

Formation flying is one of the most promising techniques for the future of astronomy and astrophysics from the space. The capabilities of the rockets strongly affect the dimensions and the weights of ... [more ▼]

Formation flying is one of the most promising techniques for the future of astronomy and astrophysics from the space. The capabilities of the rockets strongly affect the dimensions and the weights of telescopes and instrumentation to be launched. Telescopes composed by several smallest satellites in formation flying, could be the key for build big space telescopes. With this aim, the ESA PROBA-3 mission will demonstrate the capabilities of this technology, maintaining two satellites aligned within 1 mm (longitudinal) when the nominal distance between the two is of around 144m. The scientific objective of the mission is the observation of the solar corona down to 1.08 solar radii. The Coronagraph Spacecraft (CSC) will observe the Sun, when the second spacecraft, the Occulter Spacecraft (OSC) will work as an external occulter, eclipsing to the CSC the sun disk. The finest metrology sub-systems, the Shadow Position Sensors (SPS) and the Occulter Position Sensor Emitters (OPSE) identifying respectively the CSC-Sun axis and the formation flying (i.e., CSC-OSC) axis will be considered here. In particular, this paper is dedicated to the test-bed for the characterization, the performance analysis and the algorithms capabilities analysis of the both the metrology subsystems. The test-bed is able to simulate the different flight conditions of the two spacecraft and will give the opportunity to check the response of the subsystems in the conditions as close as possible to the flight ones. [less ▲]

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See detailCharacterization of the ASPIICS/OPSE metrology sub-system and PSF centroiding procedure.
Lorregia, D; Thizy, Cédric ULg; Renotte, Etienne ULg

in Proceedings of SPIE (2016, June)

Metrology in diluted systems for space applications is one of the most important technology research fields that in recent years have raised increasing interest. Many applications of astronomical ... [more ▼]

Metrology in diluted systems for space applications is one of the most important technology research fields that in recent years have raised increasing interest. Many applications of astronomical observation techniques, as coronography and interferometry get great benefit when moved in space and the employment of diluted systems represents a milestone to step-over in astronomical research. In this work, we present the Optical Position Sensors Emitter (OPSE) metrological sub-system on-board of the PROBA3. PROBA3 is an ESA technology mission that will test in-orbit many metrology techniques for the maintenance of a Formation Flying with two satellites, in this case an occulter and a main satellite housing a coronagraph named ASPIICS, kept at an average inter-distance of 144m. The scientific task is the observation of the Sun’s Corona at high spatial and temporal resolution down to 1.08R⊙. The OPSE will monitor the relative position of the two satellites and consists of 3 emitters positioned on the rear surface of the occulter, that will be observed by the coronagraph itself. A Centre of Gravity (CoG) algorithm is used to monitor the emitter’s PSF at the focal plane of the Coronagraph retrieving the Occulter position with respect to the main spacecraft. The 3 location target accuracy is 300m for lateral movement and 21cm for longitudinal movements. A description of the characterization tests on the OPSE LED sources, and of the design for a laboratory set-up for on ground testing is given with a preliminary assessment of the performances expected from the OPSE images centroiding algorithm. [less ▲]

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See detail188Re and 68Ga radiolabeled Starch-Based Microparticles as potential theranostic radiopharmaceutical for Hepatocellular Carcinoma
Verger, Elise ULg; Drion, Pierre ULg; MEFFRE, Geneviève ULg et al

in Journal of Nuclear Medicine (The) (2016, May 01), 57(suppl. 2),

The SBMP as a unique vector is a promising theranostic agent for the SIRT of HCC.

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See detailRoof Frames in the Buit Heritage of Brussels (Belgium): The contribution of dendrochronology and written sources
Weitz, Armelle ULg; Charruadas, Paulo; Fraiture, Pascale et al

in Tree Rings in Archaeology, Climatology and Ecology (2016, May), 14

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See detailMicroparticules à base d’amidon radiomarquées au 188Re et 68Ga comme agent théranostique pour la radiothérapie interne sélective du carcinome hépatocellulaire
Verger, Elise ULg; Drion, Pierre ULg; MEFFRE, Geneviève ULg et al

in Médecine Nucléaire (2016, May), 40(3), 182

Les microparticules SBMP, en étant capable d'être radiomarquées rapidement, de manière reproductible, sous forme de kits prêt-à-l‘emploi, par du 188Re et du 68Ga, se révèlent être un outil théranostique ... [more ▼]

Les microparticules SBMP, en étant capable d'être radiomarquées rapidement, de manière reproductible, sous forme de kits prêt-à-l‘emploi, par du 188Re et du 68Ga, se révèlent être un outil théranostique prometteur pour le traitement du carcinome hépatocellulaire. [less ▲]

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See detailModelling Urban Expansion: A Multiple Urban-Densities Approach
El Saeid Mustafa, Ahmed Mohamed ULg; Saadi, Ismaïl ULg; Cools, Mario ULg et al

in Proceedings of GEOProcessing 2016 (2016, April 24)

Most existing spatio-temporal urban expansion models consider urban land-use as a binary process, through the identification of urban versus non-urban areas. The main aim of this study is to analyze and ... [more ▼]

Most existing spatio-temporal urban expansion models consider urban land-use as a binary process, through the identification of urban versus non-urban areas. The main aim of this study is to analyze and model the expansion of multiple urban densities in Wallonia, Belgium. To this end, this study employs a multinomial logistic regression model that enables to visualize the consequence of different urban densities expansion. Cadastral datasets of years 2000 and 2010 are used to set four urban classes (non-urban, low-density, medium-density and high-density urban). Besides, several socio-economic, geographic and political driving forces dealing with urban development were operationalized to create maps of urban expansion probability for each urban density class. These probability maps are then utilized to predict future urban expansions for years 2020 and 2030. The model is validated using relative operating characteristic method for different urban classes. Our results suggest that different urban densities expansions are mainly linked to zoning status, neighboring areas that are urban and accessibility. Most importantly, this study highlights that the contribution of different driving forces to urban expansion process varies along with urban density. [less ▲]

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See detailDesign and Modelization of a convex grating for the hyperspectral imager Chandrayaan 2: spectral optimization based on free form profile
Sabushimike, Bernard ULg

in International Journal of Latest Research in Science and Technology (2016, April 20), 5(2), 69-74

For hyperspectral imaging, diffraction gratings based spectrometers exhibit high spectral resolution and optical performance. Among those spectrometers, the Offner type (which consists of an entrance slit ... [more ▼]

For hyperspectral imaging, diffraction gratings based spectrometers exhibit high spectral resolution and optical performance. Among those spectrometers, the Offner type (which consists of an entrance slit, two concave mirrors and convex grating) offers a lot of advantages. In this paper, we propose the design and modelization of a convex grating which covers a spectral band ranging from 0.7 μm to 5 μm with a minimum diffraction efficiency of 20% at 8 00 nm, 50% at 3000 nm and 25% at 5000 nm. For a so wide band, a grating with a single blaze cannot satisfy these requirements. Wewill therefore propose an approach of multi-blaze grating which is subdivided intodifferent sections each with its own blaze angle. Meanwhile, we perform the diffraction efficiency prediction using the scalar and rigorous theories to prove the compliance of this design with the technical specifications. The rigorous theory will also allow us to study the polarization sensitivity of this grating and the calculation of the diffraction efficiency of a grating with a profile degraded by manufacturing errors to assess the impact on the diffraction efficiency and the sensitivity to polarization. [less ▲]

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See detailUsing NDACC column measurements of carbonyl sulfide to estimate its sources and sinks
Wang; Marshall, J; Palm, M et al

in Geophysical Research Abstracts (2016, April 19), 18

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See detailAbel inversion method for cometary atmospheres.
Hubert, Benoît ULg; Opitom, Cyrielle ULg; Hutsemekers, Damien ULg et al

in Geophysical Research Abstracts (2016, April 01), 18

Remote observation of cometary atmospheres produces a measurement of the cometary emissions integrated along the line of sight joining the observing instrument and the gas of the coma. This integration is ... [more ▼]

Remote observation of cometary atmospheres produces a measurement of the cometary emissions integrated along the line of sight joining the observing instrument and the gas of the coma. This integration is the so-called Abel transform of the local emission rate. We develop a method specifically adapted to the inversion of the Abel transform of cometary emissions, that retrieves the radial profile of the emission rate of any unabsorbed emission, under the hypothesis of spherical symmetry of the coma. The method uses weighted least squares fitting and analytical results. A Tikhonov regularization technique is applied to reduce the possible effects of noise and ill-conditioning, and standard error propagation techniques are implemented. Several theoretical tests of the inversion techniques are carried out to show its validity and robustness, and show that the method is only weakly dependent on any constant offset added to the data, which reduces the dependence of the retrieved emission rate on the background subtraction. We apply the method to observations of three different comets observed using the TRAPPIST instrument: 103P/ Hartley 2, F6/ Lemmon and A1/ Siding spring. We show that the method retrieves realistic emission rates, and that characteristic lengths and production rates can be derived from the emission rate for both CN and C2 molecules. We show that the emission rate derived from the observed flux of CN emission at 387 nm and from the C2 emission at 514.1 nm of comet Siding Spring both present an easily-identifiable shoulder that corresponds to the separation between pre- and post-outburst gas. As a general result, we show that diagnosing properties and features of the coma using the emission rate is easier than directly using the observed flux. We also determine the parameters of a Haser model fitting the inverted data and fitting the line-of-sight integrated observation, for which we provide the exact analytical expression of the line-of-sight integration of the Haser model. [less ▲]

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See detailOsteoarthritic sclerotic subchondral osteoblasts secreted elevated concentration of fibulin-3 fragments in vitro
Sanchez, Christelle ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 83

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

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See detailIs isokinetic exercise dangerous for the heart?
Le Goff, Caroline ULg; Kaux, Jean-François ULg; Cavalier, Etienne ULg et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(suppl. 1 No. 2), 457

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in ... [more ▼]

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. PURPOSE: Our study aimed to observe the cardiovascular impact (by biological point of view) of maximal intense isokinetic eccentric and concentric protocols performed by a population of sedentary young men. METHOD: Resting (T0) and post-exercise (just after (T1), 3 hours (T2) and 24 hours after the exercise (T3)) blood samples were taken in 2 populations of young sedentary men: 12 subjects (22.5±1.15 yo) for the eccentric protocol and 18 subjects (22.4±2.6 yo) for the concentric protocol. These subjects performed an intense maximal isokinetic exercise of the quadriceps muscles involving 30 knee flexions–extensions for each leg. We evaluated markers of cardiovascular risk (highly sensitive troponin T (hs-TnT), N-Terminal Brain natriuretic peptide (NT-proBNP), myoglobin (MYO)), of inflammation (highly sensitive C-reactive protein (hsCRP)), muscle damage (creatine kinase (CK)) and of oxidative stress (myeloperoxidase (MPO), lipidic peroxides (POXL), reduced (GSH) and oxidised glutathione (GSSG)). Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: All the physiological parameters measured presented statistically significant changes. For the eccentric exercise, no significant modification in cardiac (NT-proBNP, hs-TNT) and inflammation (hsCRP) biomarkers was observed. However, a significant increase for CK (T3), MYO (T2), MPO (T1), POXL (T1), GSSG (T3) and ratio GSH/GSSG (T2-T3) was shown. For the concentric exercise, the results showed significant increases for the CK (T1-T2-T3), MYO (T1-T2), GSH/GSSG (T1). Evolutionary trends were also observed for the following biomarkers: NT-proBNP (T1-T2-T3), MPO (T2), and GSSG (T4). DISCUSSION and CONCLUSIONS: No modification in cardiac biomarkers was observed after the maximal eccentric isokinetic exercise but some variations can be observed for these biomarkers after the concentric exercise. However, these changes do not exceed the reference values in healthy subjects. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. Nevertheless, a significant level of oxidative stress was induced by both exercises. [less ▲]

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See detailEffectiveness of High Intensity Radial Shock Wave Therapy in The Treatment of Chronic Plantar Fasciitis
Demoulin, Christophe ULg; Vanderthommen, Marc ULg; Fromm, Aurélien et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(Suppl. 1 No. 2), 733

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain ... [more ▼]

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain, function and pressure pain threshold in patients with chronicplantar fasciitis (PF). Materials and Methods: Patients with a diagnosis of chronic (pain lasting for more than 3 months) uni- or bilateral PF with a history of failed conservative treatment were included. After a 6-week control period during which no treatment occurred, a 2-week treatment period followed by a three weeks of rest (cicatrization phase) was provided. The treatment period consisted of three radial ESWT sessions (2000 impulses of 10 Hz frequency per session with an energy flux density of 0,275mJ/mm2) separated by a one-weekinterval. Patient assessments (pain intensity, foot function and pressure pain threshold (PPT) at the site of maximum local tenderness disability) were conducted at baseline, after the 6-week control phase (pre-treatment) and at the end of the cicatrization phase (post-treatment). Results: Thirty patients (19 women (63.3%)) with chronic PF and a mean age of 51.9±11 years were included in the present study. No drop-out occurred throughout the study period. No changes were observed at the pre-treatment assessment session except for pain intensity which decreased slightly but significantly (P<0.05). At the post-treatment session, highly significant (P<0.001) and clinically meaningful changes occurred for pain intensity (-34%), foot function score (-60%) and PPT (+68%). Conclusions: The present study suggests that high dose radial ESWT is a feasible and effective way to quickly and significantly decrease pain and disability in most patients with chronic PF. [less ▲]

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See detailTen years of Denosumab (DMAB) treatment in postmenopausal women with osteoporosis. Results from the FREEDOM Extension trial.
Bone, H.G.; Brandi, M.L.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 135-136

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See detailPrevalence of frailty among nursing home, according to different operational definitions.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; GILLAIN, Sophie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 216-217

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See detailA randomized double-blind study of Denosumab (DMAB) compared with Zoledronic acid (ZOL) in postmenopausal women with osteoporosis previously treated with oral bisphosphonates
Miller, P.; Pannacciulli, N.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(SUPPLEMENT1), 42

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See detailEfficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Reginster, Jean-Yves ULg

in Osteoporosis International (2016, April), 27(supplement 1), 65

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See detailEfficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Rannou, F.; Maheu; Reginster, Jean-Yves ULg

in Osteoporosis International (2016, April), 27(supplement 1), 66

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See detailrelationship between total hip BMD T-score and incidence of nonvertebral fracture with up to 10 years of Denosumab (DMAB) treatment
Ferrari, S.; ADAMI, S.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 49-50

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See detailThe future prevalence of sarcopenia in Europe
Ethgen, Olivier ULg; Tchoconte, C.; Beaudart, Charlotte ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 53-54

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See detailPrevalence of concomitant bone and muscle wasting in patients from the SarcoPhAge study.
Locquet, Médéa ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in Osteoporosis International (2016, April), 27(supplement 1), 129

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See detailPhysical and muscle performances among elderly nursing home residents.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Croisier, Jean-Louis ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 217

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See detailEnglish translation and cross-cultural adaptation of the SarQuoL® questionnaire.
Beaudart, Charlotte ULg; Edwards, M.; Dennison, E.M. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 221-222

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See detailAge-standardized quality of life after hip or knee arthoplasty.
Neuprez, Audrey ULg; KURTH, William ULg; THIRION, Thierry ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 541-542

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See detailBrain-derived neurotrophic factor (BDNF) in normal healthy and hemodialyzed populations.
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; KOVACS, Stéphanie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 512

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See detailGood prognosis factors after a platelet rich plasma (PRP) injection for tendinopathies ?
Kaux, Jean-François ULg; Sancerne, Audrey; Libertiaux, Vincent ULg

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(suppl. 1 No. 2), 251

Introduction : Platelet-rich plasma injections are a recent treatment for chronic tendinopathies. However, this theraeutic remains controversed in litterature. Up to now, there is no prognosis factors ... [more ▼]

Introduction : Platelet-rich plasma injections are a recent treatment for chronic tendinopathies. However, this theraeutic remains controversed in litterature. Up to now, there is no prognosis factors identified to predict a good evolution after injection of PRP. Purpose: The aims of this study were to evaluate the effect of PRP injection followed by a standardized reeducation protocol among patients suffering from different tendinopathies and to determine the good prognosis factors, if any. Methods : 51 patients suffering from different tendinopathies and refractory to conventional physiotherapy were treated with a PRP injection. Prior to the injection, a blood sample was drawn and some biological parameters (glycemia, cholesterol level, …). A pain assessment was then made using a visual analog scale (VAS) and a pressure algometer. The same assessment was carried out after 6 weeks and 12 weeks when possible. Results : There is an overall significant improvement VAS score at the end of the 12 weeks follow- up. However, no correlation was found between the evolution of the clinical scores and the biological parameters measured. Discussion and Conclusions : A PRP injection followed by a program of eccentric rehabilitation positively affects the algo-functional scores of patients with tendinopathie who were refractory to conventional physiotherapy, whatever their initial biological parameters. [less ▲]

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