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See detailPurpura thrombocytopénique idiopathique...idiopathique, vraiment?
LONGTON, Julie ULg; DRESSE, Marie-Françoise ULg; Florkin, Benoît et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2016), 18(1), 112

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See detailPhysical and muscle performances among elderly nursing home residents. Results fo the senior cohort
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; CROISIER, Jean-Louis ULg et al

in Journal of Frailty & Aging (2016), 5(Supplement 1), 69

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See detailAntonymic co-presence: overview of the syntactic patterns model
Steffens, Marie ULg

in Studies van de BKL - Travaux du CBL - Papers of the LSB (2016), 10

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See detailPermutations and shifts
Charlier, Emilie ULg

in Lecture Notes in Computer Science (2016), 9840

The entropy of a symbolic dynamical system is usually defined in terms of the growth rate of the number of distinct allowed factors of length $n$. Bandt, Keller and Pompe showed that, for piecewise ... [more ▼]

The entropy of a symbolic dynamical system is usually defined in terms of the growth rate of the number of distinct allowed factors of length $n$. Bandt, Keller and Pompe showed that, for piecewise monotone interval maps, the entropy is also given by the number of permutations defined by consecutive elements in the trajectory of a point. This result is the starting point of several works of Elizalde where he investigates permutations in shift systems, notably in full shifts and in beta-shifts. The goal of this talk is to survey Elizalde's results. I will end by mentioning the case of negative beta-shifts, which has been simultaneously studied by Elizalde and Moore on the one hand, and by Steiner and myself on the other hand. [less ▲]

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See detailPharmacokinetic (PK) effects and safety of olaparib in combination with tamoxifen, anastrozole or letrozole : Phase I study
Plummer, R.; Verheul, H.M.; Langenberg, M. et al

in Journal of Clinical Oncology (2016), 34

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See detailQualités métrologiques de la version courte du Neurophysiology of Pain Questionnaire
Demoulin, Christophe ULg; Brasseur, P.; Roussel, N. et al

in Revue du Rhumatisme (2015, December), 82S

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See detailCroyances de la population générale au sujet des manipulations vertébrales
Demoulin, Christophe ULg; Baeri, D.; TOUSSAINT, Geoffrey ULg et al

in Revue du Rhumatisme (2015, December), 82S

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See detailSpiral Arms in the Disk of HD 142527
Christiaens, Valentin ULg; Casassus, Simon; Pérez, Sebastian et al

in Astronomical Society of the Pacific Conference Series (2015, December), 499

In view of its large gap, previously reported asymmetries and near-infrared (NIR) spiral arms, the transition disk of the Herbig Fe star HD 142527 constitutes a remarkable case study. Based on our ALMA ... [more ▼]

In view of its large gap, previously reported asymmetries and near-infrared (NIR) spiral arms, the transition disk of the Herbig Fe star HD 142527 constitutes a remarkable case study. Based on our ALMA observations of the disk and previous NIR images, we try to infer the origin of the observed spirals. Different scenarios, including the effect of the binary companion, unseen planets, disk self-gravity and tidal interaction by a stellar encounter, are discussed in order to constrain the origin of the spirals. We conclude that at least a combination of two of the considered scenarios are required to account for the large annular gap, the NIR spirals and all three CO spirals. [less ▲]

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See detailEvaluation of simplified flexibility evaluation tools using a unit commitment model
Quoilin, Sylvain ULg; Nijs, Wouter; Hidalgo, Ignacio et al

in IEEE Digital Library (2015, December)

Different tools and methods have been proposed in the literature to assess the required flexibility resources and needs in a particular grid or geographical area. However, few of them are readily usable ... [more ▼]

Different tools and methods have been proposed in the literature to assess the required flexibility resources and needs in a particular grid or geographical area. However, few of them are readily usable in long term energy planning models because they require small time steps and detailed data. In this paper, two candidate methods to address the flexibility issues in such models are evaluated. A unit commitment model developed at the JRC, DispaSET 2.0, is used as a test case for the different simplified flexibility assessment tools. The modelled geographical area is Belgium, using historical data for the demand and VRE curves and their day-ahead forecast. Different VRE penetration scenarios are simulated to evaluate the flexibility of the power system. The simplified assessment tools are then run with the same inputs. Results indicate significant discrepancies between the detailed Unit Commitment model and the simplified tools. The underlying reasons are described and suggestions are formulated to improve their accuracy. [less ▲]

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See detailWho are my Visitors and Where do They Come From? An Analysis Based on Foursquare Check-ins and Place-based Semantics.
Hallot, Pierre ULg; Stewart, Kathleen; Billen, Roland ULg

in Eurographics Workshop on Urban Data Modelling and Visualisation 2015 (2015, November 23)

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This ... [more ▼]

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This research investigates to what extent the anonymized data collected from social networks can be used as a basis for making activity recommendations associated with local residents versus tourists when visiting a public place, such as a museum or gallery. Using rules based on the spatial, temporal and semantics of visited places, we are able to infer if a user is likely to be local or a tourist, based on anonymous sample Foursquare data and place-based semantics retrieved using Google Places API. Using semantics of visited places, it becomes possible to infer additional information about a user based on their movements over space and time. Depending on the kind and frequency of visited places, inferences about the aim of a visit to a location are possible. This analysis could provide information to users in the form of recommendations based on their movements while travelling around an area. This study has been performed using Foursquare check-ins for visitors to the Art Institute of Chicago between March 2010 and January 2011. [less ▲]

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See detailOutgassing and chemical evolution of C/2012 S1 (ISON)
Dello Russo, Neil; Vervack, Ronald J.; Kawakita, Hideyo et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ~ 25,000) infrared ... [more ▼]

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ~ 25,000) infrared spectroscopy as part of a worldwide observing campaign. Spectra were obtained on UT 2013 October 26 and 28 with NIRSPEC at the W. M. Keck Observatory, and UT 2013 November 19 and 20 with CSHELL at the NASA IRTF. H[SUB]2[/SUB]O was detected on all dates, with production rates increasing by about a factor of 40 between October 26 (R[SUB]h[/SUB] = 1.12 AU) and November 20 (R[SUB]h[/SUB] = 0.43 AU). Short-term variability of H[SUB]2[/SUB]O was also seen as the production rate increased by nearly a factor of two during observations obtained over a period of about six hours on November 19. C[SUB]2[/SUB]H[SUB]6[/SUB], CH[SUB]3[/SUB]OH and CH[SUB]4[/SUB] abundances were slightly depleted relative to H[SUB]2[/SUB]O in ISON compared to mean values for comets measured at infrared wavelengths. On the November dates, C[SUB]2[/SUB]H[SUB]2[/SUB], HCN and OCS abundances relative to H[SUB]2[/SUB]O appear to be close to the range of mean values, whereas H[SUB]2[/SUB]CO and NH[SUB]3[/SUB] were significantly enhanced. We will compare derived chemical abundances in ISON to other comets measured with infrared spectroscopy. [less ▲]

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See detailReport on the ground-based observation campaign of 67P/Churyumov-Gerasimenko
Jehin, Emmanuel ULg

in Bulletin of the American Astronomical Society (2015, November 01), 47

Rosetta gets closer to the nucleus than any previous mission, and returns wonderfully detailed measurements from the heart of the comet, but at the cost of not seeing the large scale coma and tails. The ... [more ▼]

Rosetta gets closer to the nucleus than any previous mission, and returns wonderfully detailed measurements from the heart of the comet, but at the cost of not seeing the large scale coma and tails. The ground-based campaign fills in the missing part of the picture, studying the comet at about 1000 km resolution, and following how the overall activity of the comet varies. These data provide context information for Rosetta, so changes in the inner coma seen by the spacecraft can be correlated with the phenomena observable in comets. This will not only help to complete our understanding of the activity of 67P, but also to allow us to compare it with other comets that are only observed from the ground.The ground-based campaign includes observations with nearly all major facilities world-wide. In 2014 the majority of data came from the ESO VLT, as the comet was still relatively faint and in Southern skies, but as it returns to visibility from Earth in 2015 it is considerably brighter, approaching its perihelion in August, and at Northern declinations. I will present results from the 2014 campaign, including visible wavelength photometry and spectroscopy, and the latest results from 2015 observations. [less ▲]

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See detailPluto's atmosphere from stellar occultations in 2012 and 2013
Dias-Oliveira, Alex; Sicardy, Bruno; Lellouch, Emmanuel et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

We present results from two Pluto stellar occultations observed on 18 July 2012 and 04 May 2013, and monitored respectively from five and six sites in South America. Both campaigns involved large ... [more ▼]

We present results from two Pluto stellar occultations observed on 18 July 2012 and 04 May 2013, and monitored respectively from five and six sites in South America. Both campaigns involved large telescopes (including the 8.2-m VLT at ESO/Paranal). The high SNR ratios and multi-chord coverage provide amoung the best Pluto atmospheric profiles ever obtained from the ground.We show that a spherically symmetric, clear (no-haze) and pure N2 atmosphere with a unique temperature profile satisfactorily fits the twelve lightcurves provided by the two events. We find, however, a small but significant increase of pressure of 6% (6-sigma level) between the two dates, with values of 2.16 ± 0.2 and 2.30 ± 0.01 μbar at the reference radius 1275 km, respectively.We provide atmospheric constrains between 1190 km and 1450 km from Pluto's center, and we determine the temperature profile with accuracy of a few km in vertical scale. Our model shows a stratosphere with strong positive gradient between 1190 km (at 36 K, 11 μbar) and r =1215 km (6.0 μbar), where a temperature maximum of 110 K is reached. Above it is a mesosphere with negative thermal gradient of -0.2 K/km up to 1,390 km (0.25 μbar), at which point, the mesosphere connects itself to a more isothermal upper branch at 81 K. This profile provides (assuming no troposphere) a Pluto surface radius of 1190 ± 5 km, consistent with preliminary values obtained by New Horizons. Currently measured CO abundances are too low to explain the negative mesospheric thermal gradient. We explore the possibility of an HCN (recently detected by ALMA) cooling. This model, however, requires largely supersaturated HCN. Zonal winds and vertical compositional variations of the atmosphere are also unable to explain the observed mesospheric trend.These events are the last useful ground-based occultations recorded before the 29 June 2015 occultation observed from Australia and New Zealand, and before the NASA's New Horizons flyby of July 2015. This work can serve as a benchmark in the New Horizons context, enabling comparisons between ground-based and space results concerning Pluto's atmospheric structure and temporal evolution. [less ▲]

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See detailChariklo's size, shape and orientation from stellar occultations
Bérard, Diane; Sicardy, Bruno; Assafin, Marcelo et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Chariklo is the largest Centaur object known to date, and it is surrounded by dense and narrow rings (Braga-Ribas et al. Nature 508, 72, 2014). The size, shape and orientation of the central body are ... [more ▼]

Chariklo is the largest Centaur object known to date, and it is surrounded by dense and narrow rings (Braga-Ribas et al. Nature 508, 72, 2014). The size, shape and orientation of the central body are important parameters to better understand the dynamics of the rings.In that context, we have analyzed three stellar occultations by Chariklo and its main ring observed on June 3, 2013, April 29, 2014 and June 28, 2014. Elliptical limb fitting to Chariklo’s main body occultation chords has been performed, where we denote a (resp. b) the semi-major (resp. semi-minor) axis of the limb. Preliminary results indicate that Chariklo’s limb is elliptical with axes ratio b/a~0.89. We obtain a~133 km and b~119 km, providing an equivalent radius of R[SUB]equiv[/SUB]=√(ab)~126 km. The rms dispersion of the fit, about 4 km, is compatible with local topographic features on a small icy body. For comparison, an equivalent radius of R[SUB]equiv[/SUB]= 119±5 km, based on thermal data, is given by Fornasier et al, AA 518, L11, 2014, while Duffard et al. AA 568, A79, 2014 estimate a= 122 km and b= 117 km.Our results are obtained under the simplifying assumption that the main ring is circular and that its center coincides with that of Chariklo. Caveats and error bars will be discussed, and dynamical implications will be presented. In particular, rough estimations of the ring apsidal precession rates will be given, as well as constraints on Chariklo's density. [less ▲]

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See detailFive years of comet narrow band photometry and imaging with TRAPPIST
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

TRAPPIST is a 60-cm robotic telescope in La Silla Observatory [1] mainly dedicated to the study of exoplanets and comets. The telescope is equipped with a set of narrow band cometary filters designed by ... [more ▼]

TRAPPIST is a 60-cm robotic telescope in La Silla Observatory [1] mainly dedicated to the study of exoplanets and comets. The telescope is equipped with a set of narrow band cometary filters designed by the NASA for the Hale-Bopp observing campaign [2]. Since its installation in 2010, we gathered a high quality and homogeneous data set of more than 30 bright comets observed with narrow band filters. Some comets were only observed for a few days but others have been observed weekly during several months on both sides of perihelion. From the images, we derived OH, NH, CN, C[SUB]2[/SUB], and C[SUB]3[/SUB] production rates using a Haser [3] model in addition to the Afρ parameter as a proxy for the dust production. We computed production rates ratios and the dust color for each comet to study their composition and followed the evolution of these ratios and colors with the heliocentric distance.The TRAPPIST data set, rich of more than 10000 images obtained and reduced in an homogeneous way, allows us to address several fundamental questions such as the pristine or evolutionary origin of composition differences among comets. The evolution of comet activity with the heliocentric distance, the differences between species, and from comet to comet, will be discussed. Finally, the first results about the one year campaign on comet C/2013 US10 (Catalina) and our recent work on the re-determination of Haser scalelengths will be presented.[1] Jehin et al., The Messenger, 145, 2-6, 2011[2] Farnham et al., Icarus, 147, 180-204, 2000[3] Haser, Bulletin de l’Académie Royal des Sciences de Belgique,63, 739, 1957 [less ▲]

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See detailNitrogen Isotopic Ratios in Cometary NH2: Implication for 15N-fractionation in Ammonia
Shinnaka, Yoshiharu; Kawakita, Hideyo; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Isotopic ratios in cometary molecules are diagnostic for the physico-chemical conditions where molecules formed and are processed, from the interstellar medium to the solar nebula. Usually temperatures at ... [more ▼]

Isotopic ratios in cometary molecules are diagnostic for the physico-chemical conditions where molecules formed and are processed, from the interstellar medium to the solar nebula. Usually temperatures at the molecular formation control the fractionation of the heavier element in molecular species, e.g., D-fractionation in water.In cometary volatiles, the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in CN have been well observed (Manfroid et al. 2009, A&A, 503, 613, and reference therein) and is consistent with the ratio in HCN (a most probable parent of CN) measured in few comets (Bockelée-Morvan et al. 2008, ApJ, 679, L49). Those ratios are enriched compared to the proto-solar value by a factor of ~3. In contrast to those Nitriles, there are only few reports on [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in Ammonia (as Amine) (Rousselot et al. 2014, ApJ, 780, L17; Shinnaka et al. 2014, ApJ, 782, L16). Ammonia (NH[SUB]3[/SUB]) is usually the most abundant and HCN is the second most abundant N-bearing volatiles in cometary ice. Especially, recent observations of [SUP]15[/SUP]NH[SUB]2[/SUB] revealed the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] are comparable to those of CN. However, from the viewpoint of theoretical work, the enrichment of [SUP]15[/SUP]N in cometary NH[SUB]3[/SUB] cannot be reproduced by current chemical network models. Information about the diversity of the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] of individual comets is needed to understand the formation mechanisms/environments of NH[SUB]3[/SUB] in the early solar system.To clarify the diversity of the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in cometary NH[SUB]3[/SUB], we determine the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] for more than ten comets individually which include not only Oort cloud comets but also short period comets by using the high-resolution optical spectra of NH[SUB]2[/SUB]. These spectra were obtained with both the UVES mounted on the VLT in Chile and the HDS on the Subaru Telescope in Hawaii.The derived [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] for more than ten comets show high [SUP]15[/SUP]N-enrichment compared with the elemental abundances of nitrogen in the Sun by about factor of ~3 and has no large diversity depending on these dynamical properties. We discuss about the origin of the formation conditions of cometary NH[SUB]3[/SUB] and its physico-chemical evolution in the solar nebula based on our and other results.This work was supported by JSPS, 15J10864 (Y. Shinnaka). [less ▲]

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See detailImpact of timing administration of mesenchymal stromal cells on serum creatinine following renal ischemia/ reperfusion in rats
ERPICUM, Pauline ULg; Rowart, Pascal ULg; POMA, Laurence ULg et al

in Transplant International (2015, November), 28(S4), 1129

Experimental models of renal ischemia/reperfusion (I/R) have suggested protective effects of mesenchymal stromal cells (MSC) therapy. Still, param- eters of MSC injection, including volume, route and ... [more ▼]

Experimental models of renal ischemia/reperfusion (I/R) have suggested protective effects of mesenchymal stromal cells (MSC) therapy. Still, param- eters of MSC injection, including volume, route and timing of cell administration, remain largely debated. Particularly, MSC infusion in mouse has been shown to be beneficial “a priori” but deleterious “a posteriori” of renal I/R injury. In order to further investigate the influence of the timing of MSC administration, we used 10-week-old Lewis rats categorized in 4 groups. Groups 1 (MSC D-7, n = 10) and 2 (MSC D + 1, n = 7) received caudal i.v. injection of MSC (1.5 9 106 in 1 ml of saline) 7 days before or 1 day after renal I/R, respectively. Control groups 3 (saline D-7, n = 6) and 4 (saline D + 1, n = 6) received equal volume of saline at similar time points. Left renal ischemia (by clamping of the renal pedicle) lasted 45 min. Right nephrectomy was simultaneously performed. Blood sample was collected from inferior vena cava at 48 h post reperfusion. MSC phenotype was confirmed by FACS analysis. In groups 1 and 3, serum creatinine (SCr) reached 1.4 ` 0.7 versus 2.4 ` 0.8 mg/dl, respectively (p < 0.05). In groups 2 and 4, SCr was 4.9 ` 0.7 versus 3.3 ` 0.9 mg/dl, respectively (p < 0.001). Furthermore, SCr levels were statistically worse when MSC were administered after renal I/R in comparison to a priori infusion (p < 0.0001). In conclusion, MSC administration 7 days prior to renal I/R attenuates kidney injury in comparison to (i) saline infusion or (ii) MSC infusion 1 day after renal I/R. Conversely, on the basis of SCr levels, MSC therapy performed after renal I/R worsens kidney injury in rats. [less ▲]

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See detailTraitement par denosumab chez des hommes à masse osseuse basse: résultats à 24 mois de l'étude ADAMO
Chapurlat, R.; Langdahl, B.; Teglbjaerg, C. et al

in Revue du Rhumatisme (2015, November), 82(S1), 123-124

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See detailIncreased risk of interstitial fibrosis and tubular atrophy in controlled donation after circulatory death kidney transplantation
WEEKERS, Laurent ULg; Ledinh, H; BONVOISIN, Catherine ULg et al

in Transplant International (2015, November), 28(S4), 49118

Introduction: Comparable transplant outcomes between controlled donation after circulatory death (cDCD) and donation after brain death (DBD) kidney transplantation (KT) have been confirmed. However, few ... [more ▼]

Introduction: Comparable transplant outcomes between controlled donation after circulatory death (cDCD) and donation after brain death (DBD) kidney transplantation (KT) have been confirmed. However, few data describes the histology of cDCD-KT which is subjected to prolonged procurement warm ischemia. This study aimed to evaluate the rate of interstitial fibrosis (IF) and tubular atrophy (TA) on the surveillance biopsy performed in our unit between the 2 and 6 months post KT. Acute rejection was considered as secondary endpoint. Patients and Methods: 330 KT (226 DBD and 104 DCD) have been performed between 2008 and 2014. Surveillance or per-cause biopsy was performed in 272 recipients. Among them, the rate of adequate (≥8 glomeruli and ≥1 large-sized artery) was 76.8%. Results: IFTA was found in 11.5% and 25.7% of DBD and cDCD-KT, respectively (p = 0.004). Considering IF and TA separately, the corresponding rates were 20.4% vs 32% (p = 0.04) and 23% vs 36% (p = 0.03), respectively. If acute rejection before routine biopsy was excluded, either IF or TA rate was significantly higher in cDCD- than DBD-KT (12.6% vs 27.1%, p = 0.006; 17.6% vs 31.4%, p = 0.016; and 20.9% vs 35.7%, p = 0.015 in case of IF-TA, IF, and TA, respectively). A cDCD-KT compared to a DBD-KT was 3.11 (95%CI 1.51– 6.43, p = 0.002), 2.34 (95%CI 1.21–4.53, p = 0.011) and 2.29 (95%CI 1.23– 4.27, p = 0.009) times more likely to have IFTA, IF, and TA, respectively. Extended criteria donor (ECD) vs standard criteria donor (SCD) was also an independent risk factor for IFTA (OR = 3.11, 95%CI 1.51–6.43, p = 0.002), IF (OR = 4.86, 95%CI 1.96–12.05, p = 0.001), and TA (OR = 4.09, 95%CI 1.68– 9.93, p = 0.002). The rate of acute rejection diagnosed by SB was 7.1% and 8.9% in DBD and cDCD kidney grafts (p = ns), respectively.Conclusion: KT from cDCD increased the risk of IF-TA between 3 and 6 months post-transplant. Further studies are warranted to investigate the evolution of this phenomenon over time and its effect on graft function. [less ▲]

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See detailPourcentage de femmes atteignant des T-scores de DMO non ostéoporotiques au rachis lombaire (RL) et à la hanche totale (HT) après 8 ans de traitement par denosumab (DMAb)
Ferrari, S.; Libanati, C.; Lin, J. et al

in Revue du Rhumatisme (2015, November), 82(S1), 35-36

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See detailTransfusion needs during liver transplantation at the chu of liege (belgium): characteristics and preoperative predictive factors
PAGE, Isaline ULg; HANS, Grégory ULg; DETRY, Olivier ULg et al

in Transplant International (2015, November), 28(S4), 461272

Introduction: Liver transplantation (LT) can result in significant bleeding requiring transfusion of allogenic blood products, which potentially leads to postoperative morbidity and mortality (1). This ... [more ▼]

Introduction: Liver transplantation (LT) can result in significant bleeding requiring transfusion of allogenic blood products, which potentially leads to postoperative morbidity and mortality (1). This study aimed to determine transfusion needs during LT in our institution and its preoperative predictive factors. Material and Methods: Two hundred LT performed at the CHU Liege between 2006 and 2012 were respectively reviewed (age = 55 ` 11 yo, BMI = 25.5 ` 4.4 kg/m2, F/M = 45/155, MELD score = 19 ` 10). Transfu- sion needs of the different blood products during POD 0, and POD 0–7 were recorded. Parameters associated with the transfusion of more than 2 units of RBC (p ≤ 0.1) were identified using the Kruskal Wallis and chi square tests (table 1). These parameters were then placed into a backward stepwise logistic regression model for the transfusion of more than two units of RBC at POD 0. A p value threshold ≥0.1 was used for leaving the model. Results: Transfusion needs were: RBC = 2[0–4], FFP = 4[2–7], PLT = 1[0– 1] during POD 0; and RBC = 3[0–6], FFP = 6[3–10], PLT = 1[0–2] during POD 0–7. Preoperative factors independently associated with the transfusion of more than two units of RBC were preop Hb (0.6 [0.46–0.79], p < 0.001) and MELD score (1.13 [1.06–1.20], p < 0.001). Discussion: These results suggest that preop Hb and MELD score are associated with blood requirements during LT. [less ▲]

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See detailThird-party mesenchymal stem cell infusion in kidney transplant recipient: 6-month safety interim analysis
WEEKERS, Laurent ULg; ERPICUM, Pauline ULg; DETRY, Olivier ULg et al

in Transplant International (2015, November), 28(S4), 223-224278

Background: Mesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents. We report the 6- month safety results for the 5 first patients treated with MSC ... [more ▼]

Background: Mesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents. We report the 6- month safety results for the 5 first patients treated with MSC after kidney transplantation (KTx). Here, we address 3 specific safety issues: immunization against MSC and engraftment syndrome defined as acute graft dysfunction not related to rejection and over-immunosuppression. Patients and method: MSC production was carried out locally. MSC were not matched with kidney recipients’ HLA. Included patients were non-immunized, first transplant recipients from deceased donors. MSC (1.5–3.0 9 106/kg) infusion was planned 3 to 5 days post KTx. Patients with cardiovascular instability post KTx were excluded. All patients were treated with Basiliximab induction, Tacrolimus, Mycophenolate Mofetil and Steroid. We prospectively screened for anti-HLA antibodies at month 1, 3 and 6. Informed consent was obtained from all participants. The local ethical committee approved the protocol. Results: Collectively there were 23/50 and 29/50 HLA mismatches (MM) with kidney and MSC donor respectively, out of which 5 were shared MM. One patient developed de novo DSA, 2 patients anti-HLA antibodies against shared kidney/MSC MM and 1 patient developed 2 specific antibodies against MSC (MSCSA) at month 6. All antibodies were anti HLA class I except for 1. We did not observe any “engraftment” syndrome. Three patients experienced non- severe opportunistic infections: 1 CMV reactivation and 2 polyoma-BK virus viremia.Conclusion: We did not observe any strong safety signal. We did however observe some degree of immunization in 3 patients: 2 developed antibodies against shared kidney/MSC donor HLA MM and 1 MSCSA. [less ▲]

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See detailPourquoi dort-on?
BARREA, Christophe ULg

in 72ème Congrès du Gbpf: De Morphée au cauchemar (2015, November)

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See detailOrgan donation after euthanasia on specific patients' request in Belgium
Ysebaert, D; DETRY, Olivier ULg; Verfaillie, G et al

in Transplant International (2015, November), 28(S4), 114313

Euthanasia is since 2002 legalized in Belgium for adults under strict conditions. The patient must be in a medically futile condition, of constant and unbearable physical or mental suffering that cannot ... [more ▼]

Euthanasia is since 2002 legalized in Belgium for adults under strict conditions. The patient must be in a medically futile condition, of constant and unbearable physical or mental suffering that cannot be alleviated, resulting from a serious and incurable disorder caused by illness. This implies that also non-terminal not-cancer patients can request for euthanasia for instance in case of debilitating neurological disorder. From 2005 till 2015 more than 25 patients, suffering from diverse neuropsychiatric diseases, got their request for euthanasia granted, and subsequently asked spontaneously for the possibility of organ donation. The involved physicians, the transplant teams and the Institutional Ethics Commit- tees, had the well-discussed opinion that this strong request for organ donation after euthanasia could not be denied. A clear separation between the euthanasia request, the euthanasia procedure and the organ procurement procedure was judged necessary. After extensive preparation, finally, in Belgium, 17 patients got their wish for organ donation after euthanasia fulfilled, in several academic or non-academic hospitals and in different regions. Several requests and preparations were started for other patients but ultimately did not lead to organ donation due to patients’ personal choices or logistically reasons. The euthanasia procedure was carried out by three physicians involved in the euthanasia granting. After clinical diagnosis of cardiac death, the procurement team came in and performed the organ procurement similar as in a DCD type III procedure. Almost always, liver, two kidneys and sometimes lungs and pancreatic islets were successfully recovered and transplanted, after allocation by Eurotransplant. The possibility of organ donation after their euthanasia provides a very much improved self-image of these patients, and adds something really positive to the unfortunate end-of-life of these patients. [less ▲]

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See detailComparable transplant outcomes between DBD and DCD kidney grafts up to 5 years post-transplant: single centre experience
Ledinh, H; DETRY, Olivier ULg; DE ROOVER, Arnaud ULg et al

in Transplant International (2015, November), 28(S4), 193-194188

Introduction: This study aimed to determine the most recent results of kidney transplantation (KT) from donation after brain death (DBD) and circulatory death (DCD). Primary endpoints were graft and ... [more ▼]

Introduction: This study aimed to determine the most recent results of kidney transplantation (KT) from donation after brain death (DBD) and circulatory death (DCD). Primary endpoints were graft and patient survival, and graft function. Acute rejection and post-operative complications were assessed as secondary endpoints. Patient and Methods: This retrospective mono-center review consisted of 226 DBD- and 104 DCD-KT between 2008 and 2014. Results: Graft survival was comparable between two groups (95.1 vs. 91.1% at 1 year, 92.8 vs. 91.1% at 3 years and 89.2 vs. 91.1% at 5 years). 46% and 40% of graft loss were attributed to patient death with a functioning graft and rejection. Patient survival was comparable between 2 groups (97.8 vs. 95.1% at 1 year, 94.1 vs. 91.2% at 3 years, and 89.6 vs. 82.3% at five years). Etiology of patient death included cardiac arrest (16.7%), infection (16.7%), cancer (13.3%), and unknown cause (46.7%). Delayed graft function occurred in 14.6% of DBD- and 30.8% of DCD-KT (p = 0.001). Primary non function was encountered in 2.6% DBD- and 4.8% DCD-KT (p = ns). Graft function was worse in DCD than DBD up to 3 months post-transplant (p = 0.034), however, no difference existed afterwards. Biopsy-proven acute rejection was found in 12.8% and 13.5% of DBD- and DCD-KT during an average 3 months post- transplant (p = ns). This rate was 7.1% vs. 8.9% on surveillance biopsy performed between 3 and 6 months post-transplant (p = ns). Post-operativecomplication rate was comparable between 2 groups, concerning patient death, reoperation, transfusion, perirenal hematoma, macroscopic hematuria, urinary obstruction, wound problem, and infection. Nevertheless, contamination of preservation solution occurred more commonly in DCD than DBD (0.4% vs. 3.8%, p = 0.036). Conclusions: Despite worse early graft function, DCD-KT was not inferior to that originating from DBD up to 5 years post-transplant, therefore deserves to be used. [less ▲]

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See detailA consecutive series of 100 controlled DCD liver transplantation
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Ledinh, H et al

in Transplant International (2015, November), 28(S4), 109296

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and ... [more ▼]

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and retransplantation. The authors retrospectively reviewed a single centre experience with controlled DCD-LT in a 12-year period. Patients and Methods: 100 DCD-LT were consecutively performed between 2003 and 2014. All donation and procurement procedures were performed as controlled DCD in operative rooms. Data are presented as median (ranges). Median donor age was 57 years (16–83). Median DRI was 2.16 (1.4–3.4). Most grafts were flushed with HTK solution. Allocation was centre-based. Median recipient MELD score at LT was 15 (7–40). Mean follow-up was 35 months. No patient was lost to follow-up. Results: Median total DCD warm ischemia was 19 min (10–39). Median cold ischemia was 235 min (113–576). Median peak AST was 1132 U/l (282– 21 928). Median peak bilirubin was 28 mg/dL. Patient survivals were 90.7%, 75.5% and 70.7% at 1.3 and 5 years, respectively. Graft survivals were 88.7%, 72.1% and 67.1% at 1.3 and 5 years, respectively. Biliary complications included mainly anastomotic strictures and extrahepatic main bile duct ischemic obstruction, that were managed either by endoscopy or hepatico- jejunostomy. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Discussion: In this series, DCD LT appears to provide results similar to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. If symptomatic ischemic cholangiopa- thy is diagnosed, adequate management with endoscopy and surgical hepaticojejunostomy may avoid graft loss and retransplantation. [less ▲]

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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Transplant International (2015, November), 28(S4), 1027

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Methods: 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5–3 9 106/kg third party MSC on post-operative day 3 ` 2. These patients were prospectively compared to a group of 10 control liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. This study is in part supported by an ESOT Senior Clinical Research Grant and by the University of Liege. [less ▲]

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See detailLes machinimas : entre jeux et vidéos. Vers une poétique du détournement vidéoludique
Barnabé, Fanny ULg

in Culture Numérique (2015, October 10)

Cet article a pour objectif d’ébaucher la construction d’une théorie du détournement de jeux vidéo par les joueurs en passant, non pas par une perspective sociologique ou anthropologique, mais par ... [more ▼]

Cet article a pour objectif d’ébaucher la construction d’une théorie du détournement de jeux vidéo par les joueurs en passant, non pas par une perspective sociologique ou anthropologique, mais par l’analyse formelle des œuvres dérivées. Pour ce faire, le présent travail prend pour objet une pratique spécifique de détournement, la réalisation de machinimas, et l’aborde à travers un corpus illustratif de vidéos ayant pour point commun d’être issues des jeux Halo. L’analyse détaillée de quatre exemples prototypiques permettra de démontrer, d’une part, l’intime continuité qui existe entre la production de détournements et la pratique même du jeu (continuité qui rend donc artificielle toute tentative de démarcation stricte) et, d’autre part, la nature duelle du détournement de jeux vidéo (due à l’existence de deux aspects à détourner : le game et le play). La mise en parallèle de ces réflexions aboutira, enfin, dans la formalisation d’un modèle cartographiant les multiples formes de détournements. [less ▲]

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See detailUnderstanding how people with MS get tired while walking
Pierard, Sébastien ULg; Phan-Ba, Rémy; Van Droogenbroeck, Marc ULg

in Multiple Sclerosis Journal (2015, October 09), 23(S11), 406

BACKGROUND. Walking impairment is frequent, appears early in the disease course of MS patients (MSP), and is perceived as the most disabling symptom. When walking, patients get tired more and differently ... [more ▼]

BACKGROUND. Walking impairment is frequent, appears early in the disease course of MS patients (MSP), and is perceived as the most disabling symptom. When walking, patients get tired more and differently than healthy people (HP) [Phan-Ba et al PLOS 2012]. This limits their walking perimeter. Understanding this phenomenon is thus important to suggest adequate therapies at the right time. OBJECTIVE. Our aim is to understand how MSP get tired while walking compared to HP. Two groups of MSP are considered: those with a low disability level (MSPL) and those with a high one (MSPH). We consider two criteria to measure the disability: the EDSS and the deceleration index (DI) [Phan-Ba et al PLOS 2012]. The limit between the groups is set at DI=0.8 and EDSS=3 (inclusive for MSPL). METHODS. Many gait characteristics (GC) have been measured with the system GAIMS along a 500m path walked as fast as possible. The dataset gathers 464 visits of HP and 70 of MSP. Some people have been assessed several times. There are 33 visits in the group MSPL with the EDSS criterion, and 25 with the DI criterion. Statistical tests (Welch) were performed on the differences and relative differences of the GC measured during the first and last 100m of the test to detect differences between HP and MSPL, and between MSPL and MSPH, as in [ECTRIMS 2012 P755]. RESULTS. Both criteria for defining the groups lead to similar conclusions. For many GC, the distributions of the variations are significantly different between MSPL and MSPH. The largest difference is for the relative difference of speed (p=0.000119 for EDSS and p=0.000021 for DI). In contrast, only the variation of the average lateral distance between the feet, which is related to the size of the base of support (and thus to the balance) shows a very significant difference between HP and MSPL (p=0.000116 for EDSS and p=0.000120 for DI). The balance does not seem to change much from MSPL to MSPH. Besides, we note that the variance decreases slightly from HP to MSPL and increases a lot from MSPL to MSPH. CONCLUSIONS. Statistically, from the motor fatigue point of view, it seems that the course of the MS disease is divided in two different stages. In the first one, MSP get more tired than HP because of a deterioration of the balance. Then, in the second one, their fatigue becomes related to a faster decrease of the walking speed. This suggests that physical therapy exercises focused on the balance could be given to MSP in the early stage of the disease. [less ▲]

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See detailDefining a score based on gait analysis for the longitudinal follow-up of MS patients
Azrour, Samir ULg; Pierard, Sébastien ULg; Van Droogenbroeck, Marc ULg

in Multiple Sclerosis Journal (2015, October 09), 23(S11), 408-409

BACKGROUND. The project GAIMS [ECTRIMS 2013 P800] aims at developing a gait measuring system particularily suited for the clinical routine, and providing a reference database with the gait characteristics ... [more ▼]

BACKGROUND. The project GAIMS [ECTRIMS 2013 P800] aims at developing a gait measuring system particularily suited for the clinical routine, and providing a reference database with the gait characteristics of many MS patients (MSP) and healthy people (HP). As the gait impairments are related to the disease progression, defining an objective and quantitative score based on the gait characteristics would be useful for the longitudinal follow-up. Based on the dataset of GAIMS and machine learning techniques (MLT), a score, well correlated with the EDSS, can be defined [Azrour et al. ESANN 2014]. OBJECTIVE. Burggraaff et al. [ECTRIMS 2014 P033] showed that paired comparisons can help human raters to better judge the state of the patients. In the same spirit, we aim at predicting the difference of EDSS between two persons or between two visits of a same person, based on clinical gait measures. We show that the pairwise comparison strategy leads to a score (Gait-Score) well correlated with the EDSS and sensitive to small modifications of the gait. METHODS. The gait of 162 HP and 72 MSP (44 with EDSS>3) has been recorded and analyzed with GAIMS. The Gait-Score is defined using the MLT of [Geurts et al. 2006]. We can compute the Gait-Score of a person by comparing him to others with known EDSS, and compute the difference of Gait-Score of a same person at two different moments. We measure the merits of the Gait-Score by the correlation between the predicted Gait-Score and the EDSS, as well as the ability to detect subtle gait deteriorations among people with ataxia induced by a low dose of alcohol (data of [Piérard et al. ESANN 2014]). RESULTS. The Gait-Score is well correlated with the EDSS (Pearson’s correlation=0.8743). Moreover, it manages to detect a gait deterioration after a small alcohol intake for 19 persons out of 24 (79% correct) which is much better than what was obtained by visual inspection of neurologists (62% according to [Piérard et al. ESANN 2014]). CONCLUSIONS. Based on the accurate gait measures provided by GAIMS, we are able to derive a Gait-Score, automatically, that is well correlated with the EDSS. Moreover, this score is able to detect subtle deteriorations of the gait caused by a low dose of alcohol. These results reinforce our conviction that the use of an automatic method based on gait analysis is very promising for the longitudinal follow-up of MS patients and the assessment of the impact of new drugs and rehabilitation programs. [less ▲]

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See detailSynthèse du débat politique. Journée de réflexion au Sénat de Belgique: «Démocratie représentative : vers la fin d’un modèle ? Diagnostic et remèdes»
Verjans, Pierre ULg

in Compte-rendu du Sénat de Belgique (2015, October 01)

Les réflexions des responsables politiques en réaction aux interventions des scientifiques peuvent être interprétées en fonction de grille d'analyse de science politique, notamment celle d'Amartya Sen et ... [more ▼]

Les réflexions des responsables politiques en réaction aux interventions des scientifiques peuvent être interprétées en fonction de grille d'analyse de science politique, notamment celle d'Amartya Sen et celle de Bernard Manin. [less ▲]

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See detailSolidarités équivoques. Genet postcolonial (autour de L'Ennemi déclaré)
Denis, Benoît ULg

in Revue des Sciences Humaines (2015, October), 320(4), 157-169

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See detailA three year survey of dermatophytoses in Belgium
SACHELI, Rosalie ULg; DARFOUF, Rajae ULg; GRAIDE, Hélène ULg et al

in Mycoses (2015, October), 58(Supplement 4), 135

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide ... [more ▼]

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide. Epidemiological studies regarding dermatophyte infections have been conducted in several countries and differences in the incidence and in etiological agents have been reported for different geographical areas. That is why national surveillance of circulating strains causing dermatophytosis is crucial. The Belgian National Reference Center (NRC) for Mycoses conducted a survey on dermatophytes strains circulating from 2012 to 2014. The present study was performed to assess the profile of dermatophytosis and to identify the species involved. Methods The Belgian NRC for Mycosis collected 9138 strains between January 2012 and December 2014. The isolates were cultured from patients clinically suspected for fungal infections of skin, hair and nails. Isolates were sent by Belgian laboratories to the two labs of the Belgian NRC (UZ Leuven and CHU of Liège) in order to identify the fungus or to confirm the identification. All isolates cultured from patients of UZ Leuven and CHU of Liège were also included. Fungal identification was performed by microscopy after subculture and in case of doubtful identifications by ITS sequencing. Results .Among the 9138 samples (results of UZ Leuven and CHU of Liège combined), 3587 were identified as dermatophytes. Trichophyton. rubrum (T. rubrum) was the most prevalent species accounting for 56,17% (n=2015) of the infections from all sources, followed by T. mentagrophytes complex (21,83%, n=783). The other main etiological agents of dermatophytosis recorded in this study in descending order of prevalence were M. audouinii (n=303), M. canis (n=120), T. violaceum (n=112), T. tonsurans (n= 95), T. soudanense (n=66), M. praecox (n=59), E. floccosum (n=14) Our data reveal the predominance of anthropophilic species causing tinea capitis especially M. audouinii responsible for 36,49% (n=163/448) of hair/scalp infection. Trichophyton violaceum rarely observed in our country is frequently found as 12,8% (n=57) of the reported cases of tinea capitis are due to this species. The retrospective evaluation of data collected also shows that zoophilic strains as M. canis well represented in the past epidemiology of tinea capitis, is decreasing in frequency accounting for only 7,2% (n=32) of clinical cases. Finally, our data confirm the high prevalence of T. rubrum commonly observed in Europe as causal agent of onychomycosis (70,9%, n=1603) followed by T. mentagrophytes complex (20,9%, n=455). T. rubrum and T. mentagrophytes complex are also responsible for the majority of skin infections as they represent respectively 40% (n=386) and 24,75% (n=239) of skin dermatophytosis during the study period. Conclusions The present work has provided recent data on the prevalence of several dermatophytes species circulating in Belgium. Such data is critical for the establishment of therapeutic strategies and measures for prevention and control of dermatophytes infections. Our study confirms the predominance of T. rubrum followed by T. mentagrophytes in the Belgian population but also highlights the emergence of new anthropophilic species such as M. audouinii and T. violaceum as causative agents of tinea capitis in children in relation with African immigration. [less ▲]

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See detailEpidemiological aspects and genotypic characterization of T.violaceum strains collected during a Belgian National survey on anthropophilic tinea
SACHELI, Rosalie ULg; Dekkers, Charlotte; GRAIDE, Hélène ULg et al

in Mycoses (2015, October), 58(Supplement 4), 189

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the ... [more ▼]

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the population, the Belgian National Reference Center (NRC Liège) launched a one-year national survey in 2013. Epidemiological aspects and genotypic characterization of the strains were included. Methods The study was conducted from March 2013 up to February 2014. All Belgian laboratories were asked to send M. audouinii and T. violaceum strains isolated from hair to the NRC with a form to fill in including epidemiological data. The fungal strains were identified by microscopy or ITS sequencing in case of doubtful identification. The genotypic analysis was performed by the DiversiLab® system (bioMérieux) for DNA fingerprinting and analysis. Epidemiological data were analyzed with the help of a biostatistician. Results Amongst the collected isolates, 23 strains were confirmed as T.violaceum (results concerning the 116 M. audouinii strains have already been reported). Analysis of the epidemiological characteristics of the infected population shows that the main age category concerns 0-4 year-old children (n=9, 39,1%) with a sex-ratio M/F of 1.875. Data concerning the geographic origin of the family were present in 82,6% of the cases and reveal that patients were mainly of Ethiopian origin (n=8, 57,9% of known cases). One patient was also from Burundi showing that T. violaceum strains probably circulate mainly in East Africa. The genotypic analysis led to the distinction of 2 variants of T. violaceum. The major group was composed of 17 strains which were mainly collected in the North of Belgium and included also the reference strain (18/23, 83,3%). The other group (6 strains) was close to the major group but the analysis of the spectral superposition showed some differences between these two groups, defining two distinct variants of T. violaceum in the Belgian population. This second variant was mainly recovered from South Belgium (5/6, 83,3%). No correlation could be made between the genotypic group and a particular ethnical origin as Ethiopian subjects were found in both groups. Conclusion The DiversiLab® system proved to be an efficient method to investigate the molecular epidemiology of dermatophytes infections as reported previously for M. audouinii. These results show that two distinct isolates co-exist in Belgium providing evidence of genetic heterogeneity and a possible spread of one genotypic variant in a restricted geographic area or the co-existence of two variants circulating in different African communities. However, no clear correlation could be established between the appartenance to a group and epidemiological factors, such as age or ethnical origin. [less ▲]

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See detailValidation of the DermaGenius Nail plus multiplex assay, a new commercial PCR assay developed for the detection and identification of dermatophyte and Candida in nails
Hayette, Marie-Pierre ULg; GRAIDE, Hélène ULg; ADJETEY BAHUN, Akolé ULg et al

in Mycoses (2015, October), 58(suppl 4), 223

Objectives Superficial dermatophytosis is the most common fungal infection in humans. Diagnosis of dermatophytosis is currently based on microscopy or histology associated with culture on specific agar ... [more ▼]

Objectives Superficial dermatophytosis is the most common fungal infection in humans. Diagnosis of dermatophytosis is currently based on microscopy or histology associated with culture on specific agar media. However, direct microscopy lacks specificity and culturing has a long turn-around-time of 2-4 weeks. These limitations can be prevented by the use of molecular diagnostics. The DermaGenius (DG) multiplex kit (PathoNostics, The Netherlands) is a new commercial realtime-PCR kit, which can differentiate various dermatophytes species including the nail pathogens T. rubrum, T. mentagrophytes, T. interdigitale and 2 Candida species (C. albicans and C. parapsilosis). This study aimed at the validation of the kit on nails clippings. Results were compared with histology and culture data. Methods A set of 76 nail clippings was collected from 76 patients attending the dermatology consultation at the University Hospital of Liege on suspicion of onychomycosis. All nails were divided in three pieces for histology, culture and the PCR multiplex assay. Histologic preparations were stained with PAS staining. Cultures were performed on 2 different Sabouraud agar medium slants (bioMérieux). The DNA extraction protocol used a proteinase K pre-treatment followed by an automated DNA-extraction (EasyMag, bioMérieux). An Internal Control (IC) was included to monitor for PCR inhibition or manual errors. The realtime-PCR amplification was performed with the DG kit on a Rotor-Gene Q instrument (Qiagen) by using quantitative amplification and melting curve analysis. Results In total, 35 of 76 cases (46%) were classified as confirmed onychomycosis based on positive microscopy (M+) with or without positive culture (C+) or just by positive culture of a confirmed pathogen. Based on negative microscopy (M-) and negative culture of a confirmed pathogen, 41 cases (54%) were reported as non-fungal onychodystrophy. Agreement between DermaGenius (DG) and culture was found in 52% of the cases while 86% agreement was reported when comparing positive DG with confirmed onychomycosis. Three positive cultures (microscopy negative) were not detected by DG (2 T. rubrum, 1 C. albicans). However, DG could detect 7 additional infections (9%). Eleven discrepancies DG+/C+ were determined which could be positively confirmed in favour of DG result by ITS sequence analysis. Most discrepancies could be explained by fungal/yeast species overgrowing the agar slant, including species of Candida, Fusarium, Trichosporon, which were not considered as the source of infection. Conclusion The DermaGenius Nail plus multiplex was able to detect the most prevalent pathogenic dermatophytes species in clinical nail specimens and proved to be more sensitive and specific than culture and direct microscopy. The DNA extraction procedure has been shown to work efficiently in diagnostics which enables the physician in charge of the patient to start a dedicated treatment rapidly. [less ▲]

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See detailUsing S-Monovette° lower the rate of hemolysed specimen from a belgian academic emergency department
VRANKEN, Laura ULg; DELCOUR, Sandra ULg; CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2015, October)

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See detailOnychomycosis: is it possible to increase the cure rate?
Hayette, Marie-Pierre ULg

in Mycoses (2015, October), 58(suppl 4), 35

Onychomycosis represent about 50% of nails disorders in the world with a very variable prevalence depending of the countries considered. Dermatophytes, non-dermatophyte molds and Candida sp. are the main ... [more ▼]

Onychomycosis represent about 50% of nails disorders in the world with a very variable prevalence depending of the countries considered. Dermatophytes, non-dermatophyte molds and Candida sp. are the main causing agents. A rapid and accurate diagnosis is essential in order to give an adequate treatment to the patient. Generally, a combination of microscopy and culture is used for laboratory diagnosis. However, microscopy does not always allow the distinction between yeasts or filamentous fungi, culture takes generally about a week before identification and the result is compromised if there is contamination by not relevant fungi. Therefore commercially available PCR-based methods have been developed in order to provide a rapid and accurate identification of dermatophytes and yeasts in nails samples. Combination of microscopy and PCR may provide a rapid and specific diagnosis in 2 working days. However this methodology is still not widely used by laboratories because of the high cost. Furthermore, this technology can detect DNA from dead fungi and therefore is not suitable for assessment of treatment efficacy. Onychomycosis therapy depends on different factors such as the causative agent, the number of nails and degree of nail involvement, the type of onychomycosis, potential drug interactions or drug intolerance and a failure to previous treatments. Oral and topical antifungals are mostly used separately or in combination. Oral therapy includes azoles (itraconazole, fluconazole) and/or allylamine (terbinafin), this latter being the most frequently prescribed antifungal for treatment of onychomycosis in North America and Europe. Topical amorolfine and ciclopirox formulations can be used alone in mild cases or in case of intolerance to oral antifungals. However, one of the biggest problems of therapy for onychomycosis is the high frequency of relapse which concerns about 20 to 40% of the patients treated by oral antifungals. Different strategies have been developed to overcome this problem amongst which are: optimization of the dosing regimens (continuous vs pulse therapy) or therapy duration, combination therapy (nail debridement + antifungals, oral + topical drugs, 2 oral drugs), improving drug delivery (use of physical or chemical enhancers, and modification of the pharmacological formulation for increasing drug uptake). Some strategies such as combination therapy (oral + topical) have demonstrated enhanced efficacy and should be recommended in case of poor efficacy of the initial treatment or in case of extended infection. Prophylactic topical therapy implemented after completion of oral treatment has been shown to delay relapse. Preventive measures such as treatment of concurrent tinea pedis and/or infected family members and regular cleaning of bathroom and shower floors can help to reduce the risk of reinfection particularly when a dermatophyte is the causative agent. In conclusion, treatment for onychomycosis is associated with frequent relapse. Consequently, follow-up is mandatory and combination therapy can be necessary in case of relapse or resistance to treatment. Patients should also be aware of the preventive hygiene measures to apply in order to decrease the risk of reinfection. New strategies improving treatment efficacy are promising but their efficacy have still to be demonstrated in comparative clinical trials before their implementation in therapy. [less ▲]

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See detailSofosbuvir in combination with simeprevir +/- ribavirin in genotype 4 hepatitis C patients with advanced fibrosis or cirrhosis: a real-life experience from Belgium
Moreno, C; Lasser, L; DELWAIDE, Jean ULg et al

in Hepatology (Baltimore, Md.) (2015, October), 62(1), 746

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However ... [more ▼]

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However, efficacy and safety data of interferon-free regimens in HCV genotype 4 (G4) patients are scarce. In Belgium, Sofosbuvir (SOF) and Simeprevir (SMV) treatment is available since January 2015 for G4 patients with advanced fibrosis (F3-F4 METAVIR) for 12 weeks. Methods: analysis of HCV G4 patients receiving SOF and SMV treatment in Belgium. The aim of the study was to evaluate the safety and efficacy of the treatment. Results: 73 G4 patients were enrolled in this data collection including 32 (43.8%) patients with severe fibrosis F3 and 41(56.2%) cirrhotic patients. The study population comprised 58.9% male, 77.8% treatment experienced patients. Median age was 59 [51-66] years and 5 patients were HCV/HIV co-infected. 24 patients received the treatment associated with ribavirin, 11/32 (34.37%) of patients with advanced fibrosis and 13/41 (31.71%) of cirrhotic patients. In cirrhotic patients, median MELD and Child-Pugh score were 9 [7-12.5] and 5 [5-6], 46.2% had platelet below 100.000/mm and 28.6% had albumin below 35 g/L. W4 HCV RNA was undetectable in 31.25% (15/48). 9 of the 15 patients with undetectable W4 HCV RNA received RBV. At W12, 100% (23/23) had HCV RNA below the limit of quantification, with 6/23 still detectable. All SVR12 data will be available at the time of presentation. No patient experienced serious adverse event. Conclusions: these preliminary results in difficult-to-treat G4 HCV patients show that SOF/SIM +/- RBV treatment is safe and seems promising, in line with that was observed in G1 HCV patients. [less ▲]

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See detailMPLS Under the Microscope: Revealing Actual Transit Path Diversity
Vanaubel, Yves ULg; Mérindol, Pascal; Pansiot, Jean-Jacques et al

in ACM Internet Measurement Conference (2015, October)

Traffic Engineering (TE) is one of the keys for improving packet forwarding in the Internet. It allows IP network operators to finely tune their forwarding paths according to various customer needs. One ... [more ▼]

Traffic Engineering (TE) is one of the keys for improving packet forwarding in the Internet. It allows IP network operators to finely tune their forwarding paths according to various customer needs. One of the most popular tool available today for optimizing the use of networking resources is MPLS. On the one hand, operators may use MPLS and label distribution mechanisms such as RSVP-TE in conjunction with BGP to define multiple transit paths (for a given edge pair) verifying different constraints on their network. On the other hand, when operators simply enable LDP for distributing MPLS labels in order to improve the scalability of their network, another kind of path diversity may appear thanks to the ECMP feature of IGP routing. In this paper, using an MPLS labels analysis, we demonstrate that it is possible to better understand the transit path diversity deployed within a given ISP. More specifically, we introduce the Label Pattern Recognition (LPR) algorithm, a method for analyzing traceroute data including MPLS information. LPR reveals the actual usage of MPLS according to the inferred label distribution protocol and is able to make the distinction between ECMP and TE multi-path forwarding. Based on an extensive and longitudinal traceroute dataset obtained from CAIDA, we apply LPR and find that each ISP behavior is really specific in regard to its MPLS usage. In particular, we are able to observe independently for each ISP the MPLS path diversity and usage, and its evolution over time. Globally speaking, the main outcomes of our study are that (i) the usage of MPLS has been increasing over the the last five years with basic encapsulation being predominant, (ii) path diversity is mainly provided thanks to ECMP and LDP, and, (iii), TE using MPLS is as common as MPLS without path diversity. [less ▲]

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See detailL’image dans le concours d’architecture : Méthodologie de lecture de la représentation graphique du projet
Boutemadja, Abdelkader ULg; Reiter, Sigrid ULg

in AISV 2015 (2015, September 08)

Nous assistons depuis quelques décennies au développement de nouveaux modes de production des représentations graphiques en architecture. Ces développements ont des raisons multiples mais la principale ... [more ▼]

Nous assistons depuis quelques décennies au développement de nouveaux modes de production des représentations graphiques en architecture. Ces développements ont des raisons multiples mais la principale semble être l’essor qu’a connu l’usage de l’outil informatique dans nos sociétés de manière générale mais aussi dans les domaines de liés à l’édification dont l’architecture et l’urbanisme. Le recours aux images 3D assistées par ordinateur est aussi apparu très tôt surtout dans le cadre des concours d’architecture. Pour produire les images les plus séduisantes, les logiciels d’architecture et d’urbanisme (DAO, CAO, BIM, SIG, …) sont devenus de plus en plus performants et intuitifs. Dans le cadre plus particulier des concours d’architecture, cette utilisation de l’outil informatique et des nouveaux modes de représentation graphique se trouve exacerbée. Chaque concours devient d’occasion, pour les architectes qui y participent, de recherche et d’innovation – non seulement architecturale – mais aussi dans la manière de représenter et de communiquer cette architecture. Qu’elles sont les nouvelles stratégies de communication portées par les représentations graphiques du projet que l’architecte cherche à mettre en place dans un concours d’architecture ? Existe-t-il une logique commune, liée aux nouveaux modes de production, à ces stratégies de communication du projet ? Ces nouvelles typologies de représentation graphique ont elles une influence sur les typologies architecturales produites, plus particulièrement dans les concours d’architecture ? Ce sont ici les questions principales que nous nous posons et auxquelles nous cherchons à répondre au travers de cet article. [less ▲]

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See detailCorrelation between muscle mass and muscle strength among nursing home residents
Buckinx, Fanny ULg; Croisier, Jean-Louis ULg; Reginster, Jean-Yves ULg et al

in European Geriatric Medicine (2015, September), 6S1

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See detailQuality of life and physical components linked to sarcopenia: baseline data of the SarcoPhAge study
Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg; Petermans, Jean ULg et al

in European Geriatric Medicine (2015, September), 6S1

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See detailDevelopment and validation of a self-administrated quality of life questionnaire specific to sarcopenia: the SarQol
Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg; Rizzoli, R. et al

in European Geriatric Medicine (2015, September), 6S1

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See detailEnergy and nutrient contents of food served and consumed by nursing home residents
Buckinx, Fanny ULg; Paquot, Nicolas ULg; Allepaerts, Sophie ULg et al

in European Geriatric Medicine (2015, September), 6S1

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See detailImpact of the frailty status on muscle mass and muscle strength of nursing home residents
Buckinx, Fanny ULg; Croisier, Jean-Louis ULg; Reginster, Jean-Yves ULg et al

in European Geriatric Medicine (2015, September), 6S1

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See detailParameter Identification Methods in a Model of the Cardiovascular System
Pironet, Antoine ULg; Desaive, Thomas ULg; Dauby, Pierre ULg et al

in IFAC PapersOnLine (2015, September)

To be clinically relevant, mathematical models have to be patient-specific, meaning that their parameters have to be identified from patient data. To achieve real time monitoring, it is important to ... [more ▼]

To be clinically relevant, mathematical models have to be patient-specific, meaning that their parameters have to be identified from patient data. To achieve real time monitoring, it is important to select the best parameter identification method, in terms of speed, efficiency and reliability. This work presents a comparison of seven parameter identification methods applied to a lumped-parameter cardiovascular system model. The seven methods are tested using in silico and experimental reference data. To do so, precise formulae for initial parameter values first had to be developed. The test results indicate that the trust-region reflective method seems to be the best method for the present model. This method (and the proportional method) are able to perform parameter identification in two to three minutes, and will thus benefit cardiac and vascular monitoring applications. [less ▲]

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See detailExploring the effect of a second closely-timed infiltration of PRP to treat proximal patellar tendinopathy
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 54

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative ... [more ▼]

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. The aim of this study was to evaluate whether 2 infiltrations of PRP proves more effective than a single treatment. Material and methods: Twenty patients suffering from chronic proximal patellar tendinopathy were enrolled into the study and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. Discussion and conclusion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups at short to mid term. A second closely-timed infiltration of PRP to treat chronic proximal patellar tendinopathy is not necessary to improve the efficacy of this treatment in the short term. [less ▲]

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See detailCross-cultural adaptation and validation of the VISA-P questionnaire in French
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 112

Introduction: The Victorian Institute of Sports Assessment–Patellar (VISA-P), originally developed for English-speaking patients, assesses the severity of patellar tendinopathy symptoms. Although this ... [more ▼]

Introduction: The Victorian Institute of Sports Assessment–Patellar (VISA-P), originally developed for English-speaking patients, assesses the severity of patellar tendinopathy symptoms. Although this questionnaire has already been translated into different languages, it has never been adapted for French-speaking patients, which is surprising. Indeed, French is not only spoken by most than 275 millions of people all around the world. The aim of our study was to validate a French version and verify its psychometric properties. Materials and Methods: The translation and cultural adaptation were performed according to international recommendations in six steps: initial translation, translation merging, back translation to the original language, expert committee review to test the pre-final version, and expert committee appraisal. Once the final French version (VISA-PF) was obtained, certain psychometric properties were assessed in 92 subjects were included and divided into three groups: pathological subjects (n = 28), asymptomatic subjects (n = 22) and sports-risk subjects (n = 42). Results: The different members of the expert committee agreed with the final version. The average scores of the VISA-PF obtained were 53 (± 17) for the pathological group, 99 (± 2) for the healthy group and 86 (± 14) for the sports-risk group. The test-retest reliability of the VISA-PF was excellent with an intra-class correlation coefficient of 0.99 and good internal consistency (α = 0.9). Correlations between the VISA-PF and diverging measures of the SF-36 were low and the correlation coefficient values measured between the VISA-PF scores and converged items of the SF-36 were higher. Conclusion: The VISA-PF is understandable, reliable and suitable for French-speaking patients with patellar tendinopathy. [less ▲]

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See detailValidation of the French translation of the VISA-A
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 112-113

Introduction : The Victorian Institute of Sports Assessment– Achilles (VISA-A) was designed to evaluate the clinical severity of Achilles tendinopathy. It has been developed in English and therefore is ... [more ▼]

Introduction : The Victorian Institute of Sports Assessment– Achilles (VISA-A) was designed to evaluate the clinical severity of Achilles tendinopathy. It has been developed in English and therefore is not adapted for French-speaking patients. Although this questionnaire has already been translated into different languages but not in French. French is spoken by most than 275 millions of people and is one of the 2 official languages of the International Olympic Committee, and one of the 6 official languages and one of the 2 working languages of the United Nation Organisation. The aim of this study was to translate this questionnaires into French and to study its reliability and validity. Methods : The questionnaire was translated into French (VISA-AF) according to the "guidelines for the process of cross-cultural adaptation of self-report measures" using six steps: translation, synthesis, back translation, expert committee review, pretesting, and appraisal of the adaptation process by the expert committee. Once the final versions obtained, several psychometric proprieties such as test-retest fidelity, internal coherence, construct validity and floor and ceiling effects were evaluated. We recruited 116 subjects who were distributed in 3 groups: pathological patients (n=31), at risk athletes (n=63), healthy people (n=22). Results : The questionnaire was approved by the expert committee after the pre-final version test. On a scale ranging from 0 (theoretical minimum) to 100 (asymptomatic subject), the average scores of the VISA-PF obtained were 59 (± 18) for the pathological group, 99 (± 1) for the healthy group and 94 (± 7) for the sports-risk group. The VISA-A-F shows excellent reliability. The VISA-AF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. No floor and ceiling effects were detected during the evaluation of the two questionnaires. Conclusion : The French versions of the VISA-A is equivalent to its original version and is reliable and valid questionnaire for French speaking patients with Achilles tendinopathy. [less ▲]

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See detailComparison between VeinoPlus Sport and TENS on the recovery on young soccer players
God, Maxime; LE GOFF, Caroline ULg; Evrard, Frédéric et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 106

Introduction Every physical activity is tiresome for the body; muscles produce metabolites and lactic acid which limit its working ability. It is then necessary to efficiently and quickly recover after ... [more ▼]

Introduction Every physical activity is tiresome for the body; muscles produce metabolites and lactic acid which limit its working ability. It is then necessary to efficiently and quickly recover after the effort. In fact, a bad recovery could bring prejudice to the following performance and the athlete's physical state. Active recovery and balneotherapy together with new techniques such as cryotherapy and electro stimulation are upcoming tools to recover better. The goal of this study was to compare the impact of 2 types of electro stimulator : « VeinoPlus Sport » (VPS) and « TENS » on amateur soccer players after Yo-Yo-type effort. Material and methods In an identical context, each athlete (20 soccer players; average age 17,1 ± 0,79) benefited from VPS and TENS during 2 different treatment sessions after 2 Yo-Yo-type efforts. Four blood samples were taken (lactate, blood gases, ions, cardiac markers,...) and an explosiveness Myotest evaluation was conducted respectively before effort, just after effort, after recovery, and after the second effort. A questionnaire on the fatigue state was filled out by each athlete. For the statistical analysis, we used the Anova algorithm of the StatPlus system and a Scheffé test. Results All athletes have ran a greater distance in their second effort especially in the VPS group but differences were insignificant. The test lead to a significant variation of lactate, HCO3- ions and myoglobin. The study of other blood parameters and of the explosiveness parameters didn't show any significant variations. Nevertheless according to the subjective athlete's opinion the VPS group has noted less legs pain, less overall fatigue, less diminishment of strength and fitter than the TENS group between 12 and 24 hours after effort. Finally all athletes have said to like the use of a electro-stimulation recovery device better than their normal daily recovery techniques without expressing any preferences between VPS and TENS. Discussion - Conclusion This comparative study only shows minor differences, non significant, between the two devices. The two groups have ran the greatest distance during the second effort which suggests that the test wasn't tiresome despite biological signs of "fatigue". However on subjective criteria of recovery and well-being a slight preference was shown for the VPS device. The results should be taken into consideration in a other comparative study of the recovery devices with more tiresome effort. [less ▲]

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See detailInvolvement of adamalysin proteases in modulations of tumor microenvironment and premetastatic niches
Donati, Kim ULg; Bekaert, Sandrine; Sepult, Christelle ULg et al

in European Respiratory Journal (2015, September), 46(59),

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See detailImpact of an ultra-trail of 330 km on plasma levels of cardiac biomarkers
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Gergelé, Laurent et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 77

Introduction/Aim: While a moderate exercise produces beneficial effects on the cardiovascular system, consequences of a supraphysiological effort are not yet clear. The aim of our study was to evaluate ... [more ▼]

Introduction/Aim: While a moderate exercise produces beneficial effects on the cardiovascular system, consequences of a supraphysiological effort are not yet clear. The aim of our study was to evaluate the consequences of such an effort on cardiac markers, markers of inflammation but also markers of renal function. This project also studied the evolution of new biomarkers of cardiac fibrosis such as the ST2 and galectin-3. Material and Methods: 51 people attending the Tor des Géants (330 km, with an altitude range of 24,000 meters) have been followed. The study is conducted on 33 participants having reached at least half of the race (148.7 km). Blood and urine samples were collected at four different times: before the race, halfway, at the finish and three days after arrival. Several biomarkers were assayed on different analyzers such COBAS®, KRYPTOR®, VIDAS® and ETIMAX®. Meanwhile, the ST2 was measured manually. Results: During this ultra-endurance effort, the plasma levels of cardiac markers (hsTnT, NT-proBNP, copeptin, H-FABP, ST2, Gal-3), muscle (CK, myoglobin) and inflammation (CRP DFO, GB) have increased significantly to halfway (148.7 km). Meanwhile, the markers of renal function (urinary NGAL and plasma and urinary creatinine) have only slightly varied, excepting plasma creatinine. Conclusions: The study suggests that there is no permanent structural damage at the myocardium level. However, the low pace adopted by the runners, due to fatigue, caused an inflammatory response as well as muscle damage less important than a shorter race. Nevertheless, an endurance race as the Tor des Géants means an intense physical and psychological effort. [less ▲]

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See detailOne-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies
Kaux, Jean-François ULg; Bruyère, Olivier ULg; Croisier, Jean-Louis ULg et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 113

Introduction: Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the ... [more ▼]

Introduction: Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies. Material and methods : Twenty subjects with chronic upper patellar tendinopathy benefited from 1 infiltration of PRP. The follow-up (up to 1 year) was assessed by means of a Visual Anologue Scale (VAS), the International Knee Documentation Committee (IKDC) form and the Victorian Institute of Sport Assessment (VISA-P) score. Moreover, subjects had to answer an information questionnaire concerning their life and sports activities. Results : Seventy percents of the patients reported a favourable evolution with decrease of pain, and returned to sports activities. With time, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. Conclusion : This study confirms that a local injection of PRP coupled with a program of eccentric rehabilitation for treating a chronic jumper's knee, improves pain symptoms and the functionalities of the subjects’ knee up to 1 year after injection. [less ▲]

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See detailModel-Based Stressed Blood Volume is an Index of Fluid Responsiveness
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

in IFAC PapersOnLine (2015, September)

Fluid therapy is frequently used to manage acute circulatory failure. This therapy aims to restore cardiac output by fluid administration, which increases the quantity of fluid in the circulation. However ... [more ▼]

Fluid therapy is frequently used to manage acute circulatory failure. This therapy aims to restore cardiac output by fluid administration, which increases the quantity of fluid in the circulation. However, it has been shown to be effective only in certain cases, leading to the need for indices of fluid responsiveness. Total stressed blood volume has recently been shown to be such an index of fluid responsiveness. However, the current methods to determine this parameter require specific procedures. In this work, a more straightforward method is developed using data available in the intensive care unit. A simple three-chamber cardiovascular system model is used, of which total stressed blood volume is a parameter. All model parameters (including total stressed blood volume) are adjusted to pig experimental data during fluid administrations. The resulting value of total stressed blood volume is always negatively associated with the relative change in cardiac output after fluid administration. This finding confirms that total stressed blood volume is an index of fluid responsiveness. Another finding of this study is that the response curves are subject-specific. The method developed in this work can be applied to humans, since the data required is typically available in an intensive care unit. [less ▲]

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See detailTHE IMPLEMENTATION OF REGIONAL ANAESTHESIA BLOCK ROOMS IN BELGIUM: A NATIONAL SURVEY
BINDELLE, Simon ULg; LECOQ, Jean-Pierre ULg; Sermeus, Luc et al

in Regional Anesthesia & Pain Medicine (2015, September), 40(5), 162

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See detailHTLV-1/BLV antisense-RNA dependent host gene perturbation in pre-leukemic and leukemic clones
Rosewick, Nicolas; Durkin, Keith ULg; Marçais, Ambroise et al

in Retrovirology (2015, August 28), 12(1),

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See detailImproving the methodology for the detection of proviral integration sites in the host genome via high throughput sequencing.
Durkin, Keith ULg; Artesi, Maria ULg; Rosewick, Nicolas et al

in Retrovirology (2015, August 28), 12(1),

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See detailUSING OF AN EXPERIMENTAL DESIGN TO CHARACTERIZE THE CONVECTIVE DRYING BEHAVIOR OF DIFFERENT SLUDGES
Fraikin, Laurent ULg; Salmon, Thierry ULg; Herbreteau, Benjamin et al

in Drying Technology (2015, August 18), 33(11), 1302-1308

Drying appears as a major step prior to valorization of sludge from wastewater treatment plant. This study uses an experimental design on different sludges to highlight the drying behavior according to ... [more ▼]

Drying appears as a major step prior to valorization of sludge from wastewater treatment plant. This study uses an experimental design on different sludges to highlight the drying behavior according to drying conditions, storage and extrusion. This research is performed with industrial view, but on a single cylinder sample, and focuses on five responds: maximum drying flux, time to reach 95% of dry matter, final volume, critical moisture and slowing-down coefficient. [less ▲]

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See detailBiotechnological potential of the microflora associated with the brown alga Ascophyllum nodosum
Martin, Marjolaine ULg; Martin, Renée ULg; Barbeyron, Tristan et al

in Journal of Microbial and Biochemical Technology (2015, August 18), 7(4), 179

Bacteria associated with algae are underexplored despite their huge biodiversity and the fact that they differ markedly from those living freely in seawater. These bacterial communities are known to ... [more ▼]

Bacteria associated with algae are underexplored despite their huge biodiversity and the fact that they differ markedly from those living freely in seawater. These bacterial communities are known to represent great potential for the production of diverse bioactive compounds, such as specific glycoside hydrolases, as they interact in multiple complex ways with their host. Furthermore, enzymes from marine bacteria have original properties, like cold-adapted, halotolerant and highly stable, which are constantly searched out by bio-industries. The aim of our study was to identify bacteria, associated with the brown alga Ascophyllum nodosum, showing diverse polysaccharolytic activities. To isolate cultivable microorganisms, algal thalli of Ascophyllum nodosum were swabbed with sterile cotton tips and marine agar plates were inoculated. Three-hundred isolated bacteria were screened for agarase, kappa- and iota-carrageenase, and sulfatase activities on specific marine media. Thirty-two bacteria with polysaccharolytic activities were isolated and a part of their 16S rDNA (8F-1492R) were amplified and sequenced. Twenty-seven were classified as Flavobacteriia and five as Gammaproteobacteria. Putative new strains and species of Zobellia, Maribacter, Cellulophaga, Shewanella, Glaciecola, Pseudoalteromonas and Colwellia were identified by phylogenetic analysis. All those genera are well-known to colonize algal surface but only some of them are famous to degrade algal polysaccharides (Zobellia, Maribacter, Cellulophaga, and Pseudoalteromonas). However, all those novel bacterial strains/species showed multiple and diverse enzymatic activities (agarase, iota-and kappa-carrageenase, cellulase, beta-glucosidase, sulfatase and/or amylase activities). Genomics libraries with their DNA were constructed in Escherichia coli and Bacillus subtilis and are screened to identify the genes coding for the observed enzymatic activities. Those novel glycoside hydrolases from unknown marine bacteria should have original and innovative properties with great biotechnological potential. [less ▲]

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See detailNEAs: Phase Angle Dependence of Asteroid Class and Diameter from Observational Studies
Wooden, Diane H.; Lederer, Susan M.; Bus, Schelte et al

in IAU General Assembly (2015, August 01), 22

We will discuss the results of a planned observation campaign of Near Earth Asteroids (NEAs), 1999 CU3, 2002 GM2, 2002 FG7, and 3691 Bede with instruments on the United Kingdom Infrared Telescope (UKIRT ... [more ▼]

We will discuss the results of a planned observation campaign of Near Earth Asteroids (NEAs), 1999 CU3, 2002 GM2, 2002 FG7, and 3691 Bede with instruments on the United Kingdom Infrared Telescope (UKIRT) from 15-Mar-2015 to 28-April 2015 UT. We will study the phase-angle dependence of the reflectance and thermal emission spectra. Recent publications reveal that the assignment of the asteroid class from visible and near-IR spectroscopy can change with phase angle for NEAs with silicate-bearing minerals on their surfaces (S-class asteroids) (Thomas et al. 2014, Icarus 228, 217; Sanchez et al. 2012 Icarus 220, 36). Only three of the larger NEAs have been measured at a dozen phase angles and the trends are not all the same, so there is not yet enough information to create a phase-angle correction. Also, the phase angle effect is not characterized well for the thermal emission including determination of the albedo and the thermal emission. The few NEAs were selected for our study amongst many possible targets based on being able to observe them through a wide range of phase angles, ranging from less than about 10 degrees to greater than 45 degrees over the constrained date range. The orbits of NEAs often generate short observing windows at phase angles higher than 45 deg (i.e., whizzing by Earth and/or close to dawn or dusk). Ultimately, lowering the uncertainty of the translation of asteroid class to meteorite analog and of albedo and size determinations are amongst our science goals. On a few specific nights, we plan to observe the 0.75-2.5 micron spectra with IRTF+SpeX for comparison with UKIRT data including 5-20 micron with UKIRT+UIST/Michelle to determine as best as possible the albedos. To ensure correct phasing of spectroscopic data, we augment with TRAPPIST-telescope light curves and R-band guider image data. Our observations will contribute to understanding single epoch mid-IR and near-IR measurements to obtain albedo, size and IR beaming parameters (the outcomes of thermal models) and asteroid spectral class. [less ▲]

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See detailLes recherches sur la médecine dans l’Égypte gréco-romaine au Centre de Documentation de Papyrologie Littéraire (CEDOPAL) de l’Université de Liège
Marganne, Marie-Hélène ULg

in Histoire des Sciences Médicales (2015, August), 49(2), 233-237

The paper presents the research on medicine in Greco-Roman Egypt conducted in the last forty years at the Centre de Documentation de Papyrologie Littéraire (CEDOPAL) at the University of Liège. It ... [more ▼]

The paper presents the research on medicine in Greco-Roman Egypt conducted in the last forty years at the Centre de Documentation de Papyrologie Littéraire (CEDOPAL) at the University of Liège. It describes the main results obtained by deciphering, editing, translating and commenting Greek and Latin medical papyri, be they literary, documentary or magical. [less ▲]

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See detailThe effects of triclosan exposure in shape changes of sheepshead minnow (Cyprinodon variegatus) during early development and metamorphosis
Schnitzler, Joseph ULg; Frederich, Bruno ULg; Dussenne, Mélanie ULg et al

in Organohalogen Compounds (2015, August)

Thyroid hormones are essential for normal development, and for maintenance of normal physiological functions in vertebrates [1, 2]. In fish, thyroid hormones are involved in the control of osmoregulation ... [more ▼]

Thyroid hormones are essential for normal development, and for maintenance of normal physiological functions in vertebrates [1, 2]. In fish, thyroid hormones are involved in the control of osmoregulation, metabolism, somatic growth and post-hatching metamorphosis [1, 3, 4]. The regulation of thyroid hormone bioavailability in tissues and cells represents a very complex and unique web of feedback systems [2]. In fish and other vertebrates the thyroid cascade involves two components. First, thyroxine (T4) biosynthesis and secretion are largely under central control by the brain–pituitary–thyroid axis [5]. Second, there is the conversion of T4 to its biologically active form 3,5,3-triiodothyronine (T3) and its metabolism and receptor-mediated actions that seems largely to be under peripheral control in extra-thyroidal tissues [6]. The accumulation in the aquatic environment of anthropogenic chemicals, among which are endocrine disrupting chemicals (EDCs) that alter normal hormonal regulation, is having dramatic consequences for humans and wildlife. Numerous chemicals disrupt thyroid homeostasis affecting thyroid hormone (TH) synthesis and transport, and cellular uptake and metabolism [7, 8]. Triclosan (TCS) is a synthetic chlorinated phenolic compound with a generalized use as an antimicrobial and preservative in many personal care and household products [9-11]. As a result of disposal of TCS through sewage systems and insufficient/variable removal by wastewater treatment plants (WWTP) [9], widespread contamination with TCS has been detected in several countries, particularly in aquatic ecosystems, WWTP influents and effluents; sludges and biosolids; surface or ground water; drinking water; and aquatic sediments [9-11]. TCS and its metabolites have been detected in tissues and body fluids of aquatic organisms including fish, revealing they are accumulating in the food chain [9-11] and TCS has also been detected in human blood, breast milk and urine [9-11]. The structural similarity of TCS with THs [9] suggest it may have adverse effects on the thyroid system. However, little is known about the mechanisms by which TCS disrupts the thyroid axis. TCS effects on fish thyroid axis have not been investigated. It is possible, that the TCS toxic effects reported in fish embryos, larvae and adults [9-11] might be caused, at least in part, through its effect on the thyroid system. We determined how TCS affect ontogenic variations of thyroid hormones in developing sheepshead minnow larvae. Knowing that thyroid hormones are involved in somatic growth and post-hatching metamorphosis, we also tested the hypothesis that TCS alter the development of these larvae. To do this, we used landmark-based geometric morphometric methods. These methods allowed us to analyse the pure shape variations of our developing larvae, regardless orientation, position, and size. [less ▲]

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See detailDynamique de l'espace architectural : force, vitesse, déplacement dans l'oeuvre de Le Corbusier
Steinmetz, Rudy ULg

in Revue Philosophique de Louvain (2015, August), Tome 113(3), 425-447

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See detailIsolation and identification of anthropogenic particles in fish stomachs by Raman spectroscopy: a new method
Collard, France ULg; Gilbert, Bernard ULg; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2015, August)

Microplastic particles (MP) contaminate oceans and affect marine organisms in several ways. Ingestion combined with food intake is generally reported. However, data interpretation is often circumvented by ... [more ▼]

Microplastic particles (MP) contaminate oceans and affect marine organisms in several ways. Ingestion combined with food intake is generally reported. However, data interpretation is often circumvented by the difficulty to separate MP from bulk samples. Visual examination is often used as one or the only step to sort these particles. However, color, size and shape are insufficient and often unreliable criteria. Here we present an isolation method of MP specially adapted to a subsequent analysis by Raman spectroscopy. This method avoids fluorescence problems allowing the identification anthropogenic particles (AP) from stomach contents of fish by Raman spectroscopy. It was validated with commercial samples of microplastics and cotton along with stomach contents from three different Clupeiformes fishes: Clupea harengus, Sardina pilchardus and Engraulis encrasicolus. The optimized digestion and isolation protocol showed no visible impact on microplastics and cotton particles while the spectroscopic analysis allowed precise identification of microplastics and textile fibers. This approach allowed us to isolate 35 particles. These were analyzed by Raman spectroscopy: eleven were microplastics and thirteen were made of cellulose or lignin, or both (mostly fibers). Some particles were not identified but contained artificial colorants. This isolation protocol will help to assess the presence, quantity and composition of AP in planktivorous fish stomachs. [less ▲]

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See detailANALYSE DES PHÉNOMÈNES CLIMATIQUES EXTRÊMES DANS LE SUD-EST DU NIGER
Karimou Barké, Mahamadou Salifou ULg

in Publications de l'Association Internationale de Climatologie (2015, July 01), 28

The climate of the Department of Goure and Maine Soroa(Southeast of Niger) is of the saharo-sahelian’s type. Extreme climatic events are isolated weather phenomena, which coincide in space and time to ... [more ▼]

The climate of the Department of Goure and Maine Soroa(Southeast of Niger) is of the saharo-sahelian’s type. Extreme climatic events are isolated weather phenomena, which coincide in space and time to affect agricultural production, livestock breeding and natural resource stocks. In order to qualify and quantify regionally climate extremes, the statistical tool used is the extreme value distribution according to the Gumbel’s law. The results show that the occurrence of warm days and nights tends to increase while cool nights decreases. [less ▲]

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See detailHow to determine the place provided to physical activity in a primary school? An attempt to identify objective variables
Mouton, Alexandre ULg; Boone, Pauline; Cloes, Marc ULg

in Revista Espaňola de Educación Física y Deportes (2015, July), 410-S

In the fight against sedentariness, recent meta analyses underlined the determining role of school as a foundation for physical activity (PA) promotion in children and adolescents (Biddle et al. 2012 ... [more ▼]

In the fight against sedentariness, recent meta analyses underlined the determining role of school as a foundation for physical activity (PA) promotion in children and adolescents (Biddle et al. 2012). Consequently, active schools projects are implemented worldwide.. They combine actions on several parallel axes with the physical education (PE) teacher as a corner stone. One of the challenges of such interventions is to follow the modifications and measure their effects. Moreover, it seems that practitioners and researchers still need an instrument to ascertain the real place provided to PA in a school. The aim of this presentation consists in describing the development, validation and testing of an instrument designed to provide such feedback. This study respects a qualitative approach and, by its step by step process, could be considered as an action research approach. Its main goal is to produce an audit instrument rather than providing data. Five successive steps were designed: Analysis of the literature in order to select the main dimensions to analyze; Development of a provisional tool based on objective items; Pilot study; Validation by a group of 13 experts; Testing of the final version in a school. The analysis was focused on the school policy and involved the principal, the PE teacher and the classroom teachers. 335 items were identified and spread across six dimensions. The experts underlined the validity and completeness of the instrument. For the practitioners, participating to the data collection is a means to become aware of what the school (should) propose. This study points out the large range of variables involved in the development of a PA school project, and bring forward the limitation of an assessment using objective data. It underlines that an audit process contributes to a more relevant perception of the reality. Practitioners would also be interested by an easier-to-use tool. [less ▲]

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See detailIntergenerational physical activity: Effects of a three-month intervention bringing together older adults and elementary school children
Mouton, Alexandre ULg; Renier, Tom ULg; Cloes, Marc ULg

in Revista Espaňola de Educación Física y Deportes (2015, July), 410-S

For the first time in history, children are projected to have a shorter life expectancy than their parents (Olshansky et al., 2005). Besides, older adults are the less active population group (Sun et al ... [more ▼]

For the first time in history, children are projected to have a shorter life expectancy than their parents (Olshansky et al., 2005). Besides, older adults are the less active population group (Sun et al., 2013). Intergenerational PA has the potential to increase PA and quality of life (QoL) among those two age-groups but research in the field is still very limited (Flora & Faulkner, 2007). Accordingly, the aim of this study was to examine the impact of an intergeneration PA intervention on self-reported PA and Qol among older adults and elementary school children. At baseline, two intergenerational groups were formed: (Gr1) 11 older adults (63.91±7.62 years) and a class of 18 children (4.81±0.37 years); (Gr2) 9 older adults (68.67±7.25) and a class of 13 children (7.16±0.38years). Those groups took part in a three-month intergenerational intervention including one weekly session of PA practiced in the school context. Assessments were performed before (T0), during (satisfaction level), after the intervention (T1) and after a three months’ follow-up period (T2). PA and Qol were respectively assessed with the QAPPA and the SF-36 among older adults, and with adapted versions of the PAQ-C and the AUQUEI among children. Older adults’ physical fitness was also assessed with the SFT battery test. Participation rate was relatively high in both groups during PA sessions (Gr1: 81.48% older adults and 93.21% children; Gr2: 83.33% older adults and 91.45% children). At T1, Only 1 older adult (Gr1) dropped out of the study, as 9 children (group 1) and 6 children (group 2) dropped out due to the failure of the parents to complete and return the children’s questionnaires. Preliminary results of the SFT exposed significant improvements of the upper limbs strength in both groups (p<0.05). Further analyses will inform about effects on PA and Qol. [less ▲]

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See detailQuality and Innovation, key factors for laboratory evolution
HUYNEN, Pascale ULg

in Clinical Chemistry & Laboratory Medicine (2015, June 23)

Today the laboratory has to face many challenges: constant increase of number of tests to be run, private labs that competes in reaching a lower TAT, disease outbreak that arises without the possibility ... [more ▼]

Today the laboratory has to face many challenges: constant increase of number of tests to be run, private labs that competes in reaching a lower TAT, disease outbreak that arises without the possibility of human control, like the recent mumps outbreak, the need to provide fast results in case of emergency or for transplants, the request to keep high level of traceability of all results, the accreditation of the lab are just some examples. With the same number of operators, year after year, new clinical needs have to be satisfied in a timely manner, with efficiency and without compromise in quality. The solution for us has been, across several year, to look for innovation. Moving from Elisa to chemiluminescence and therefore from open systems to close and state of the art systems, it has allowed us to face with success all those challenges. The availability of more and more infectious disease markers on fully automated analyzers, with good level of performance, have let us to cope with all the changes that have happened across more than a decade. Indeed innovation and quality are fundamental to support properly the laboratory evolution that occurred since today and it is still occurring. Innovation in our laboratory it is also represented by the introduction of automatized tests not only on serum and plasma specimens, but also on CSF (for Lyme disease diagnosis) and on stool matrix. In 2013 in fact we have introduced, among the assays already tested in our laboratory, two assays performed on this matrix, the C. difficile Toxin A&B and GDH, due to the possibility offered by the LIAISON® systems to run all of them on the same serology platform, without crosscontamination. New markers will be available in the near future, and our laboratory will be always able to meet the next clinical needs. [less ▲]

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See detailLiminarité, métadiscours, et théâtre voltairien
Daubercies, Laurence ULg

in Revue Voltaire (2015, June 12)

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See detailOxidative stress or not in healthy older subjects?
PINCEMAIL, Joël ULg; CHRISTELBACH, Sophie ULg; RICOUR, Céline ULg et al

in OCC2015 (2015, June)

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See detailEstimation du délai entre la consommation d'héroïne et le prélèvement de sang chez des consommateurs chroniques
DUBOIS, Nathalie ULg; Charlier, Corinne ULg

in Toxicologie Analytique & Clinique (2015, June), S27(2), 43

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See detailEvaluation d'une trousse de dépistage de l'éthylène glycol par méthode enzymatique
DEVILLE, Marine ULg; HALENG, Jeanine ULg; Henrad, Valérie et al

in Toxicologie Analytique et Clinique (2015, June), S27(2), 60-61

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See detailThe Instability Strip of ZZ Ceti White Dwarfs
Van Grootel, Valérie ULg; Fontaine, G.; Brassard, P. et al

in Astronomical Society of the Pacific Conference Series (2015, June), 493

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection ... [more ▼]

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection in these stars. We report here a detailed stability survey over the whole ZZ Ceti regime, including the low and extremely low masses. We computed to this aim 29 evolutionary sequences of DA models with various masses, chemical layering, and core compositions. These models are characterized by the so- called ML2/α=1.0 convective efficiency and take into account the important feedback effect of convection on the atmospheric structure. We computed pulsation spectra for these models with the Liège nonadiabatic pulsation code MAD, which is the only one to conveniently incorporate a full time-dependent convection treatment and, thus, provides the best available description of the blue edge of the instability strip. On the other hand, given the failure of all nonadiabatic codes to account properly for the red edge of the strip, including MAD, we tested the idea that the red edge is due to energy leakage through the atmosphere. Using this approach, we found that our theoretical ZZ Ceti instability strip accounts remarkably well for the boundaries of the empirical strip. [less ▲]

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See detailDevelopment of a full fiber-coupled laser ultrasound robotic system using two-wave mixing 1064 nm detection and 532 nm YAG generation
Vandenrijt, Jean-François ULg; Simar, Juan Felipe ULg; Thizy, Cédric ULg et al

in Laser Ultrasonics and Advanced Sensing (2015, June)

An all-fibered laser ultrasonic system for complex shape composite parts is presented. It is based on two-wave mixing detection and a long pulse laser working at 1064 nm and generation by a fibered YAG Q ... [more ▼]

An all-fibered laser ultrasonic system for complex shape composite parts is presented. It is based on two-wave mixing detection and a long pulse laser working at 1064 nm and generation by a fibered YAG Q-switch laser working at 532 nm. A compact optical head combining both beams is interfaced to a robot system for scanning. Some practical issues of this system are studied. [less ▲]

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See detailA First Look at the Nonadiabatic Properties of Pulsating Accreting White Dwarfs of the GW Lib Type
Van Grootel, Valérie ULg; Fontaine, G.; Brassard, P. et al

in Astronomical Society of the Pacific Conference Series (2015, June), 493

We present results of a detailed stability survey of the pulsation properties of accreting white dwarfs of the GW Lib type. This is based on several state-of-the- art white dwarf evolutionary sequences ... [more ▼]

We present results of a detailed stability survey of the pulsation properties of accreting white dwarfs of the GW Lib type. This is based on several state-of-the- art white dwarf evolutionary sequences with varying envelope compositions, from pure hydrogen to pure helium. Using the same tools as in Van Grootel et al. (2013), where we have presented the first consistent view of the ZZ Ceti instability strip, we have mapped the GW Lib instability strip over the effective temperature-surface gravity plane, and as a function of envelope composition. We find that the location of the GW Lib instability domain is a strong and continuous function of the assumed envelope composition. We can accomodate all of the known GW Lib pulsators in various strips according to their atmospheric compositions. [less ▲]

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See detailHigh-speed Photometric Observations of ZZ Ceti White Dwarf Candidates
Green, E.M.; Limoges, M.-M.; Gianninas, A. et al

in Astronomical Society of the Pacific Conference Series (2015, June), 493

We present high-speed photometric observations of ZZ Ceti white dwarf candidates drawn from the spectroscopic survey of bright DA stars from the Villanova White Dwarf Catalog by Gianninas et al., and from ... [more ▼]

We present high-speed photometric observations of ZZ Ceti white dwarf candidates drawn from the spectroscopic survey of bright DA stars from the Villanova White Dwarf Catalog by Gianninas et al., and from the recent spectroscopic survey of white dwarfs within 40 parsecs of the Sun by Limoges et al. We report the discovery of six new ZZ Ceti pulsators from these surveys, and several photometrically constant DA white dwarfs, which we then use to refine the location of the ZZ Ceti instability strip. [less ▲]

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See detailMethod and Tools for an Objective Approach of White Dwarf Asteroseismology
Charpinet, S.; Giammichele, N.; Brassard, P. et al

in Astronomical Society of the Pacific Conference Series (2015, June), 493

Stellar oscillation modes propagate deep inside stars and carry on information potentially allowing us to reconstruct, through asteroseismology, parts of their internal structure and dynamics. We present ... [more ▼]

Stellar oscillation modes propagate deep inside stars and carry on information potentially allowing us to reconstruct, through asteroseismology, parts of their internal structure and dynamics. We present and discuss here our strategy and tools developed to exploit objectively this potential for pulsating white dwarf stars. Our approach relies on a multimodal optimization technique aimed at identifying all potential seismic model solutions that best match the observed periods of a given star. This approach doesn't rely on model grids (hence avoiding their limitations) and makes use of static stellar structures of white dwarf stars as opposed to evolutionary models. The use of parameterized static models is a deliberate choice in this context and is aimed at approaching as closely as possible the real structure of the star as it is observed and probed by the detected oscillation modes without interferences from unavoidable model uncertainties propagated through billion years of evolution. We argue that this strategy is more likely to produce new tight constraints on the internal structure of white dwarf stars from which evolutionary models could be improved. [less ▲]

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See detail[18F]UCB-H as a new PET radiotracer for Synaptic vesicle protein 2A: A first clinical trial.
Bahri, Mohamed Ali ULg; Stifkens, M; Bastin, Christine ULg et al

in Tijdschrift voor Nucleaire Geneeskunde (2015, May 09), 37(3), 1457-1458

The synaptic vesicle protein 2A (SV2A) is widely distributed in the brain and has been demonstrated to be involved in vesicle trafficking. The critical role of SV2A in proper nervous system function is ... [more ▼]

The synaptic vesicle protein 2A (SV2A) is widely distributed in the brain and has been demonstrated to be involved in vesicle trafficking. The critical role of SV2A in proper nervous system function is shown, e.g., by the fact that it is a binding site and the primary mechanism of the antiepileptic drug levetiracetam. This drug has recently been suggested to reduce synaptic deficits in a mouse model for Alzheimer’s disease. We here aimed to investigate the cerebral distribution of [18F]UCB-H, which has a high affinity with the SV2A. Dynamic PET data of the head of 4 healthy volunteers were acquired over 100 minutes after injection of 170.4 ± 24.9 MBq of GMP produced [18F]UCB-H. The arterial input function (IF) was obtained by blood sampling but also derived from the dynamic data using the correlation coefficient method. Blood data revealed a consistent amount of [18F]UCB-H in whole blood and plasma indicating a very low degree of binding of the tracer to the red blood cells. The unchanged fraction of [18F]UCB-H in plasma showed a bi-exponential behavioral decrease with a starting fraction of 92% of the injected amount of the tracer, measured at 3 min post injection. This fraction decreased to about 50% at 10 min post injection. The image-derived arterial IFs showed to be very similar to the measured ones with a peak-ratio around 0.91 and an area-under-curve ratio about 0.98. The PET images showed a high and rapid uptake of [18F]UCB-H in the grey matter structures, matching the known ubiquitous distribution of the SV2A in the brain. The kinetics of the tracer in the brain was characterized by an initial high uptake phase followed by rapid washout. For the three standard compartmental models (1-tissue, 2-tissue, and Logan Plot), similar results were obtained with both the measured and image-derived IFs. Nevertheless the two-tissue compartment model fitted the experimental data best and provided a total distribution volume of the [18F]UCB-H in the brain greater than 7 mL/cm3 and a specific distribution volume around 3 mL/cm3. Our results suggest that [18F]UCB-H is a good candidate as radiotracer for brain SV2A proteins and could be used for human studies (dosimetry has already been reported elsewhere). Image-derived IF showed to be useful for quantitative studies without the need to the arterial blood sampling. This new tracer could help to assess SV2A modifications in neurological pathologies such as Alzheimer’s disease. [less ▲]

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See detailSujet de disputes ou objet de partage ? L’anthropologue au centre de conflits entre enfants de 5 à 8 ans (Liège, Belgique)
Campigotto, Marie ULg

in AnthropoChildren : Perspectives ethnographiques sur les enfants & l'enfance = Ethnographic Perspectives in Children & Childhood (2015, May 08)

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See detailSujet de disputes ou objet de partage ? L’anthropologue au centre de conflits entre enfants de 5 à 8 ans (Liège, Belgique)
Campigotto, Marie ULg

in AnthropoChildren : Perspectives ethnographiques sur les enfants & l'enfance = Ethnographic Perspectives in Children & Childhood (2015, May 08)

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See detailTrace element contamination severity of coastal waters: A first bioassessment at the scale of the whole Mediterranean Sea
Richir, Jonathan ULg; Salivas-Decaux, Maylis; Lafabrie, Céline et al

in PeerJ (2015, May)

Human activities generate large volumes of waste that supply marine coastal environments in pathogens, organic matter, nutrients and toxicants. Among the wide range of toxicants are trace elements. Since ... [more ▼]

Human activities generate large volumes of waste that supply marine coastal environments in pathogens, organic matter, nutrients and toxicants. Among the wide range of toxicants are trace elements. Since the latter are toxic for aquatic organisms from threshold levels and as they are therefore likely to cause multiple damage to the population, the community and the ecosystem levels, their environmental occurrence has to be accurately monitored in order to guarantee appropriate environmental management of coastal zones and to preserve marine coastal ecosystems and the goods and services they provide. In the framework of the STARECAPMED project, the present study aimed to monitor, for the first time, the coastal contamination of the entire Mediterranean by As, Ag, Cd, Cu, Hg, Ni and Pb, using Posidonia oceanica (L.) Delile as bioindicator species. But sustainable coastal management also requires the development of appropriate contamination classification systems intended, among other purposes, for environmental managers and policy makers. The combined utilization of several complementary monitoring tools, i.e. water quality scale, pollution index (TEPI and TESVI) and spatial analysis (PCA, CA, correlation analysis and GIS mapping) successfully led to the development of an operational classification system of this kind. In particular, the mapping of the trace element contamination according to a new proposed 5-level water quality scale using the quantile method precisely outlined the contamination severity along Mediterranean coasts and facilitated interregional comparisons. The reliability of the use of P. oceanica as bioindicator species was further again demonstrated through several global, regional and local detailed case studies. In conclusion, holistic approaches such as developed in the present study should be privileged to accurately monitor the contamination rate of coastal waters and to transfer relevant information on this composite problem to environmental managers and policy makers. [less ▲]

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See detailSeagrasses or caged mussels to bioassess the contamination rate of Mediterranean coastal waters? That is the question
Richir, Jonathan ULg; Galgani, François; Benedicto, José et al

in PeerJ (2015, May)

Biological indicators have the capacity to integrate the temporal changes of contaminants, concentrations or fluxes over various time-scales, and are thus considered as interesting tools for water quality ... [more ▼]

Biological indicators have the capacity to integrate the temporal changes of contaminants, concentrations or fluxes over various time-scales, and are thus considered as interesting tools for water quality biomonitoring. Since the mid-70ies, French programs have developed water monitoring approaches based on the use of bivalve molluscs; and recently the natural background and the extent of water contamination were bioassessed at the scale of the whole western Mediterranean. But even if bivalve molluscs are viewed as reliable bioindicators, their use is not always made easy as a result of their absence in numerous coastal regions that force their transplantation (cages) during several months before their sampling and analysis. This weakness led several scientists to evaluate the bioindicator abilities of other marine organisms. Seagrasses, whose ability to bioaccumulate contaminants proportionally to environmental contamination levels has been clearly demonstrated, have thus been proposed as an appropriate alternative tool for coastal water quality assessment. Very little studies have however so far considered the combined utilization of these two groups of bioindicator organisms, i.e. caged bivalve molluscs and seagrasses. In the framework of the STARECAPMED project, we therefore compared and discussed the bioaccumulation of trace elements in the Neptune grass Posidonia oceanica and in caged Mediterranean mussels Mytilus galloprovincialis. The sampling was performed at the scale of the western Mediterranean. The two species told two contamination stories which, although sometimes different, showed to be complementary. P. oceanica and M. galloprovincialis bioaccumulated dissolved trace elements from the water column and thus provided information regarding trace element contamination severity integrated over several days to a few months. Seagrasses, strongly rooted in the sediments, reflected the long-term exposure to trace elements since sediments offer a degree of time integration over several years to decades. Caged mussels, as filter feeder artificially maintained in the water column, bioaccumulated trace elements from their particulate phase, and therefore gave valuable information regarding continental-terrigenous inputs to coastal waters. In conclusion, seagrasses and mussels should neither supplant, nor substitute, but rather complement each other in order to provide the full time- and space-integrated coastal contamination story of the Mediterranean. [less ▲]

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See detailA phase 1b study of Trebananib plus Paclitaxel and Trastuzumab or Capecitabine and Lapatinib in patients with HER2+ locally recurrent or metastatic breast cancer
Kaufman, P.A.; Freyer, G.; Kemeny, M. et al

in Cancer Research (2015, May), 75(9), 5-19-14

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See detailOne-year Prevalence of Migraine Using a Validated Extended French Version of the ID MigraineTM: a Belgian Population-Based Study
Schoenen, Jean ULg; Streel, Sylvie ULg; Donneau, Anne-Françoise ULg et al

in Cephalalgia : An International Journal of Headache (2015, May), 35(6), 155-156

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See detailHigh output [18F]FDOPA on AllInOne (Trasis) at commercial scale
Otabashi, Muhammad; Cascione, Christian; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2015, May), 58

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See detailThird-party mesenchymal stem cell infusion in kidney transplant recipient: 6-month safety interim analysis
WEEKERS, Laurent ULg; ERPICUM, Pauline ULg; DETRY, Olivier ULg et al

in American Journal of Transplantation (2015, May), 15(suppl 3),

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See detailUPLC®-MS/MS, an analytical tool for the accurate and rapid quantification of phytoestrogen metabolites in milk
Daems, Frédéric ULg; Jasselette, Christophe; Romnee, Jean-Michel et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015, April 17), 19(2), 121-122

The term ‘phytoestrogen’ is used to define a wide variety of nonsteroidal compounds that occur naturally in many plants. When they are absorbed by cows, these polyphenolic compounds undergo ... [more ▼]

The term ‘phytoestrogen’ is used to define a wide variety of nonsteroidal compounds that occur naturally in many plants. When they are absorbed by cows, these polyphenolic compounds undergo biotransformation by specific bacteria present in the gastrointestinal tract. The resulting metabolites are absorbed in the organism and some are excreted in milk. The impact of these compounds on human health divides opinion. Some scientists believe that they might have adverse health effects. Others believe the opposite, especially with regard to their microbial metabolites, such as equol. Whatever one's view on the subject, scientists need accurate, sensitive and rapid analytical methods in order to continue the research on clarifying the phytoestrogen issue. Cow's milk is an animal product that is common in the human diet, and it is therefore important to evaluate its content of phytoestrogen metabolites. In order to study the human intake of equol via commercial milk, an analytical method was developed and validated following EMA/CVMP/VICH/463202/2009 guidelines. Enzymatic hydrolysis was used to release the equol. It was then extracted using double liquid/liquid extraction and analyzed using UPLC®-MS/MS, with an analysis runtime of only 5 min. This analytical method produced a linear calibration curve with a high correlation coefficient (R2≥0.996) between 5 and 1,000 ng mL−1. Good intra- and inter-day precision (RSDs≤5.3% and ≤5.2%, respectively) and accuracy (bias≤8.6%) were achieved. The recovery rate differed slightly among the different types of milk, ranging between 60.6±1.09% and 82.3±5.21%. Good method repeatability was observed (RSDs<15%). There was neither a matrix effect nor a carry-over effect, and the sample extracts were stable during storage for at least 7 days at −21°C and 5°C. In order to apply the proposed method and obtain an initial estimate of equol concentration in cow’s milk in Belgium, 44 samples of various brands found in several supermarkets and 5 raw milk samples from Walloon farms were analyzed. Equol was found in all the samples analyzed, with a concentration ranging from 10 to 50 ng mL−1 for conventional milk and from 70 to 130 ng mL−1 for organic milk. These results were compared with other European studies and the same trend was observed. The results obtained show the specificity, sensitivity and precision of this method for analyzing oestrogenic metabolite-equol in cow’s milk. This study should be extended to include a greater number of samples and be implemented over a longer period to see if there is a correlation between livestock practice and/or sample origins with the equol content in milk. The addition of other phytoestrogen compounds with this method, using UPLC®-MS/MS technology, could also lead to more reliable monitoring of these compounds in dairy production. [less ▲]

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