References of "Paper published in a journal"
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See detailSpectrum of clinical manifestations due to mycoplasma pneumoniae infections in children
Denis, C.; Magotteaux, Samia ULiege; Seghaye, Marie-Christine ULiege et al

in Belgian Journal of Paediatrics (2017, March), 19(1), 64

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See detailA case report of a lumbosacral spondylodiscitis in a young child
Pirotte, Isabelle ULiege; TAXHET, Arnaud ULiege; DESPRECHINS, Brigitte ULiege et al

in Belgian Journal of Paediatrics (2017, March), 19(1), 67

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See detailFulminant hepatic failure in a 3-month child due to paracetamol treatment
Morgenthal, Charline ULiege; CROCHELET, Anne-Sophie ULiege; Bequet, Emeline ULiege et al

in Belgian Journal of Paediatrics (2017, March), 19(1), 45

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See detailPharmacokinetics of Cefazolin in maternal and umbilical cord of full-term newborns
Menschaert, Denis ULiege; Janssen, Aurélie ULiege; MISTRETTA, Virginie ULiege et al

in Belgian Journal of Paediatrics (2017, March), 19(1), 71

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See detailImpact of an ultra-marathon of 330km on plasma levels of cardiac biomarkers
Le Goff, Caroline ULiege; Kaux, Jean-François ULiege; Gergelé, Laurent et al

in British Journal of Sports Medicine (2017, February), 51(4), 347

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See detailIntention, image et singularité selon le premier Sartre : réflexion sur les propriétés et les fonctions de l'acte d'imagination
Recchia, Fabio ULiege

in Bulletin d'Analyse Phénoménologique (2017, February)

Partant d’une problématisation de la méthode phénoménologique mise en jeu par "L’Imaginaire", nous proposons de relire les développements de ce texte à partir de la perspective offerte par la théorie de ... [more ▼]

Partant d’une problématisation de la méthode phénoménologique mise en jeu par "L’Imaginaire", nous proposons de relire les développements de ce texte à partir de la perspective offerte par la théorie de l’intentionnalité du premier Sartre. Nous tenterons ainsi de dégager l’unité systématique du projet sartrien d’une « phénoménologie de l’image » en le rapportant aux propositions philosophiques posées de manière décisive par "l’article sur l’intentionnalité". Par ce biais, il s’agira également de fixer les propriétés de la conscience imageante, ainsi que les fonctions jouées par l’acte d’imagination dans l’économie générale de la conscience, en particulier dans l’événement de sa personnalisation. De sorte que nous parcourons les tensions reliant l’imagination de la conscience à son ipséité ; tandis que, du point de vue de l’histoire de la philosophie, nous examinerons certaines des torsions qu’appliqua Sartre sur l’analyse husserlienne de l’image afin d’approfondir celle-ci dans la direction d’une philosophie de la liberté personnelle du sujet. [less ▲]

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See detailUne série consécutive de 125 greffes hépatiques à partir de donneurs cadavériques en mort circulatoire
DETRY, Olivier ULiege; MEURISSE, Nicolas ULiege; HANS, Marie-France ULiege et al

in Transplant International (2017, January), 30(Suppl 1), 2481

Introduction: Donation after circulatory death (DCD) has been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and ... [more ▼]

Introduction: Donation after circulatory death (DCD) has been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and retransplantation. The authors retrospectively reviewed a single centre experience with controlled DCD-LT in a 14-year period. Patients and Methods: 125 DCD-LT were consecutively performed between 2003 and 2016. All donation and procurement procedures were performed as controlled DCD in operative rooms. Data are presented as median (ranges). Median donor age was 56 years (16–84). Most grafts were flushed with HTK solution in the first part of experience, and more recently with IGL1. Allocation was centre-based. Median follow-up was 52 (1–164) months. No patient was lost to follow-up. Results: Median total DCD warm ischemia was 19 min (9–39). Median cold ischemia was 238 min (105–576). Patient survivals were 90.2%, 77.5% and 74.5 % at 1.3 and 5 years, respectively. Graft survivals were 87.7%, 76.3% and 73.2% at 1.3 and 5 years, respectively. Biliary complications included anas- tomotic strictures and extrahepatic main bile duct ischemic obstruction, that were managed either by endoscopy or hepatico-jejunostomy. No PNF was observed in this series and one graft was lost due to ischemic cholangiopathy. Discussion: In this series, DCD LT appears to provide results similar to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. [less ▲]

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See detailUNE INJECTION UNIQUE DE CELLULES STROMALES MESENCHYMATEUSES AU JOUR 3 APRES GREFFE HEPATIQUE EST INSUFFISANTE POUR INDUIRE UNE TOLERANCE OPERATIONNELLE
DETRY, Olivier ULiege; VANDERMEULEN, Morgan ULiege; DELBOUILLE, Marie-Hélène ULiege et al

in Transplant International (2017, January), 30(suppl 1), 812

Introduction: Mesenchymal stromal cell (MSC) infusion could be a mean to establish donor-specific immunological tolerance in solid organ recipients. The aim of this phase 2 study was test the hypothesis ... [more ▼]

Introduction: Mesenchymal stromal cell (MSC) infusion could be a mean to establish donor-specific immunological tolerance in solid organ recipients. The aim of this phase 2 study was test the hypothesis of possible induction of operative tolerance by third-party MSC in liver transplant (LT) recipients. Methods: 10 stable and low-risk LT recipients under standard immunosup- pression (Tac-MMF- low dose steroids) received 1.5–3 9 106/kg third-party MSCs on post-operative day 3 ` 2. By protocol, progressive weaning of immunosuppression was attempted in patients who did not develop rejection and had normal graft function and month-6 graft biopsy. Tacrolimus was progressively tapered from day 180 to be discontinued by day 270. After day- 270 graft biopsy, MMF was progressively tapered and definitely discontinued by day 365 in the absence of rejection. Results: One patient from the MSC group was excluded from immunosup- pression withdrawal attempt due to HCC recurrence, and the 9 others met the necessary criteria. In one patient, tacrolimus and MMF withdrawal was performed without rejection. In two patients, MMF monotherapy was achieved at month 9, but graft rejection occurred during MMF withdrawal and was successfully treated by tacrolimus reintroduction. In 6 patients, the transam- inases significantly increased during tacrolimus withdrawal. In these cases, withdrawal was cancelled and liver tests normalised after increase of the tacrolimus dose. No graft was lost due to the withdrawal attempt. Conclusion: A single post transplant MSC injection is not sufficient to induce operative tolerance after LT. [less ▲]

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See detailUne anomalie du Congrès de Vienne : le Territoire neutre de Moresnet : Repenser la frontière politique et linguistiqueomalie du Congrès de Vienne : le Territoire neutre de Moresnet : Repenser la frontière politique et linguistique
Robelin, Cyril ULiege

in Austriaca (2017, January)

An anomaly in the Congress of Vienna: Neutral Moresnet or how to rethink the political and linguistic boundaries. Neutral-Moresnet was a 3.4 km² neutral territory near Aachen. Its history is the result of ... [more ▼]

An anomaly in the Congress of Vienna: Neutral Moresnet or how to rethink the political and linguistic boundaries. Neutral-Moresnet was a 3.4 km² neutral territory near Aachen. Its history is the result of a misunderstanding. In Article 25 of the Vienna Final Act, Moresnet is annexed to Prussia, but in Article 66 this province is placed under Dutch sovereignty. In the site of "Vieille-Montagne” an important zinc mine is discovered. They decided to establish co-sovereignty. From then on, two commissioners oversee the area. Over time, Moresnet developed a national folklore, especially with the process of Nation-State at the end of the 19th century. This triangle is seen by foreign observers as the smallest country in the world and even as an "imaginary country" (vampires, new Eldorado). Some Esperantists hoped to make Moresnet the country of international languages ​​because in this tiny territory German, French and dialects are spoken. Moresnet rethinks the concept of border. After the Treaty of Versailles in 1919, this small state belongs to Belgium. [less ▲]

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See detailImpact of the cumulated proteins and energy deficits on ICU patient’s outcome
PAGE, Isaline ULiege; Warnier, Stéphanie; NYS, Monique ULiege et al

in Annals of Intensive Care (2017, January), 7(Suppl1), 200

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See detailQuartz-enhanced photo-acoustic spectroscopy for breath analyses
Petersen, J; Lamard, L; Feng, P et al

in Proceedings SPIE (2017, January), 10055

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See detailPotential use of estetrol in sensorineural hearing loss protection
DELHEZ, Amandine ULiege; Manfroid, Isabelle ULiege; LEFEBVRE, Philippe ULiege et al

in B-ENT (2017)

Introduction and Aims: Estrogens have a positive impact on the auditory function. Indeed, estradiol (E2) treatment in animals protects against acoustic trauma and aminoglycoside toxicity and its depletion ... [more ▼]

Introduction and Aims: Estrogens have a positive impact on the auditory function. Indeed, estradiol (E2) treatment in animals protects against acoustic trauma and aminoglycoside toxicity and its depletion can contribute to age-related hearing loss. However, estradiol is not suitable in clinical practice, given the increased risk of cancer and thromboembolic events. There is a need to find new treatments that present a higher benefit/risk ratio. In this work, we studied a new natural estrogen derivative, estetrol (E4), that was shown to act as a Selective Estrogen Receptor Modulator (SERM). Estetrol is thus able to display estrogen-like as well as antiestrogen activity depending on the target tissue. Interestingly, E4 allows the prevention of menopause symptoms such as osteoporosis or hot flushes through an agonistic action, whereas it exerts anti-estrogenic effects on the mammary gland. These preclinical data suggest that E4 presents a safer profile than E2. Material and Methods: To investigate whether this molecule presents otoprotective actions, we exposed P2 cultured organs of Corti to gentamicin, with or without estetrol (E4). After 48 hours of culture, hair cell survival was evaluated following anti-myosin VII Immunohistochemistry. We next moved on to in vivo studies using young zebrafish larvae (5dpf), since they constitute a highly effective model to determine the potential ototoxicity of drugs and to screen for candidates of hair cell protective agents. We monitored the survival of hair cells within neuromasts following chronic or acute exposure to gentamicin. Results: In cochlear culture, gentamicin-induced hair cell loss was significantly reduced by E4. Interestingly, the toxicity of aminoglycoside was also reduced in vivo upon treatment of zebrafish larvae with E4. Conclusion: The survival rate of hair cells was increased in the presence of estetrol both in vitro and in vivo indicating that estetrol constitutes an interesting protective drug against hearing loss. [less ▲]

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See detailAssessing Inter-and Intramolecular Continuous-Flow Strategies towards Methylphenidate Hydrochloride
Gerardy, Romaric ULiege; Winter, Marc; Vizza, Alessandra et al

in Reaction Chemistry and Engineering (2017)

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both ... [more ▼]

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both inter- and intramolecular strategies imply the telescoping of multiple processing steps and the generation of unstable diazospecies under continuous-flow conditions. The intermolecular strategy relies on an unprecedented continuous-flow Rh-catalyzed intermolecular C-H carbene insertion, providing enriched threo-N-Boc methylphenidate in 38% or 19% isolated yield according to sequential or fully telescoped processes, respectively. Quantitative Boc-deprotection is carried out off-line. The intramolecular strategy relies on a continuous-flow thermal intramolecular C-H carbene insertion, providing enriched threo-methylphenidate hydrochloride in 70% isolated yield. A continuous-flow photochemical alternative is also presented. The critical step of the most promising intramolecular strategy is implemented on mesoscale in a pilot-scale continuous-flow reactor. [less ▲]

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See detailResults of the SarcoPhAge study after 2 years of follow-up.
Beaudart, Charlotte ULiege; Locquet, Médéa ULiege; Reginster, Jean-Yves ULiege et al

in Journal of Frailty & Aging (2017), 6 Suppl 1

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See detailOn the Elaboration of Metal-Ceramic Composite Coatings by Laser Cladding
Mertens, Anne ULiege; L'Hoest, Thibaut; Magnien, Julien et al

in Materials Science Forum (2017), 879

This paper reports on a preliminary investigation into the elaboration, by the additive process known as laser cladding, of composite coatings with a matrix of stainless steel 316L reinforced with varying ... [more ▼]

This paper reports on a preliminary investigation into the elaboration, by the additive process known as laser cladding, of composite coatings with a matrix of stainless steel 316L reinforced with varying contents of tungsten (WC) or silicon carbides (SiC) particles. Laser cladding is characterised by ultra-fast solidification and cooling rates, thus giving rise to ultra-fine out-of-equilibrium microstructures and potentially enhanced mechanical properties. Both types of composite coatings – i.e. with SiC or WC ‒ are compared in terms of their microstructures and hardness. Special attention is given to the dissolution of the carbides particles and to interfacial reactions taking place between the particles and the metallic matrix. [less ▲]

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See detailEffects of a giant exercising board game intervention on ambulatory physical activity among nursing home residents: a preliminary study
Mouton, Alexandre ULiege; Gillet, Nicolas; Mouton, Flore et al

in Osteoporosis International (2017), 28(S1), 318

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See detailMechanical loading therapy increases bone formation while reducing bone resorption following implantation in a mouse model of postmenopausal osteoporosis
Li, Zihui; Betts, Duncan; Kuhn, Gisela et al

in JBMR Plus (2017)

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See detailAssociation entre les taux circulants de matrix-gla protein et rigidité artérielle en transplantation rénale.
Dinic, M; Maillard, N; DELANAYE, Pierre ULiege et al

in Néphrologie & Thérapeutique (2017), 13(5), 309

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See detailPROPOSITION D'UN SUPPORT D'AIDE À LA DÉCISION POUR L'AMÉLIORATION DE L'ACCÈS À UNE EAU SOUTERRAINE DE MEILLEURE QUALITÉ DANS UN CONTEXTE DE CONTAMINATION GÉOGÉNIQUE AU FLUORURE AU BENIN (AFRIQUE DE L'OUEST)
Tossou, Joël; Hermans, Thomas ULiege; Orban, Philippe ULiege et al

in Geo-Eco-Trop : Revue Internationale de Géologie, de Géographie et d'Ecologie Tropicales (2017)

Les eaux souterraines des aquifères de socle cristallin de la partie centrale du Bénin (Département des Collines) présentent des concentrations élevées en fluorure, allant jusqu'à 7 mg/L alors que la ... [more ▼]

Les eaux souterraines des aquifères de socle cristallin de la partie centrale du Bénin (Département des Collines) présentent des concentrations élevées en fluorure, allant jusqu'à 7 mg/L alors que la norme recommandée par l'OMS est de 1.5 mg/L. La consommation de ces eaux à fortes teneurs en fluorure impacte la santé humaine. La population de la région est effectivement largement affectée par la fluorose dentaire. Les investigations hydrogéochimiques révèlent que l’origine de ces teneurs anormales est géogénique avec une forte contribution des minéraux ferromagnésiens, principalement la biotite. Ce travail se propose de réaliser une double cartographie à l'échelle du département des Collines: (i) une carte de l'estimation des teneurs en fluorure dans les eaux souterraines par krigeage ordinaire et (ii) une carte de la probabilité d'excéder la valeur guide de l’OMS (1.5 mg/L) en fluorure dans les eaux par krigeage d'indicatrices. Outre la cartographie en elle-même, l'analyse de la structure spatiale des données (teneurs en fluorure des eaux souterraines) à travers le calcul des variogrammes montre qu'il existe un lien fort entre celles-ci et les structures géologiques dominantes, confirmant l'origine géogénique du fluorure. Ces informations cartographiques serviront de support à la décision pour les décideurs et les gestionnaires de la ressource quant au choix judicieux des zones de captage d'eau potable pour minimiser/éviter les risques de fortes teneurs en fluorure. [less ▲]

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See detailA surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
Farhat, Khalil; Bodart, Gwennaelle; Martens, Henri ULiege et al

in Neuroimmunomodulation (2017)

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See detailEnergetic and Environmental Performances of a Domestic Hot Water Condensing Boiler Fired by Wood Pellets
Ngendakumana, Philippe ULiege; Gabriele, Fabian; Restivo, Yannick et al

in Energy Procedia (2017)

In order to assess the performances of the domestic heating boilers with a CE mark, a wood pellets fired condensing boiler has been purchased and installed in the Laboratory for tests. The objective of ... [more ▼]

In order to assess the performances of the domestic heating boilers with a CE mark, a wood pellets fired condensing boiler has been purchased and installed in the Laboratory for tests. The objective of the study was not only to check the announced performances, but mainly to investigate the influence of the different parameters affecting the functioning of the boiler, the thermal efficiency and the pollutants (NOx and CO) emission being aimed at. Tests have been performed to study the influence of the cycling frequency of the burner functioning, the overall excess air, the return water temperature, and the output power of the boiler. As announced by the manufacturer, the tested boiler fulfils the requirements of the Blue Angel Label, but the recommended value for the excess air (1.2) can be reduced to a value of about 0.4 without excessive emissions of CO. The boiler could perform better if the ON period of the cycle of the burner is increased even better if the OFF period is suppressed. The NOx are mainly formed from the nitrogen content of the pellets and their emissions can only be reduced by a lower nitrogen content of the pellets than the limit stated in the standard. Random peaks observed in the evolution of CO, the boiler being operating in steady state regime, are attributed to the combustion process of pellets which is a non-continuous process by nature. [less ▲]

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See detailPreliminary assessment of the possibilities of the Particle Finite Element Method in the numerical simulation of bird impact on aeronautical structures
Cerquaglia, Marco Lucio ULiege; Deliège, Geoffrey ULiege; Boman, Romain ULiege et al

in Procedia Engineering (2017), 173

As well known, in the analysis of bird impact events the bird is often reduced, even experimentally, to a surrogate projectile modeled as a weakly compressible fluid (typically a mixture of water and air ... [more ▼]

As well known, in the analysis of bird impact events the bird is often reduced, even experimentally, to a surrogate projectile modeled as a weakly compressible fluid (typically a mixture of water and air). From a numerical standpoint, the presence of a free surface and the strong interaction with the aircraft structures represent a limit for traditional computational fluid dynamics methods based on an Eulerian grid. On the other hand, classical Lagrangian methods cannot cope with the extremely large deformations experienced by the projectile during the impact. The Particle Finite Element Method (PFEM) is a Lagrangian particle method that can account for very large deformations, preserving the robustness and generality of the finite element method, and thus owning a key advantage over other approaches, e.g. Smoothed Particle Hydrodynamics (SPH), usually cursed with consistency and stability issues. To assess the possibilities of the method in the context of bird impact, theoretical analyses are initially performed based on the impact of a water jet on a rigid surface. Then, the influence of the geometry of a more realistic projectile is analyzed and the capability of the method to take into account separation and fragmentation is highlighted. [less ▲]

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See detailRelationship bewteen weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: Secondary analyses of a randomised trial
Bartels, E; Henrotin, Yves ULiege; Bliddal, H et al

in Osteoarthritis and Cartilage (2017), 25

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See detailTesting a New Memory Task Sensitive to Early Entorhinal/Perirhinal Atrophy in Alzheimer's disease
Besson, Gabriel ULiege; Simon, Jessica ULiege; Salmon, Eric ULiege et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2017)

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See detailDecision algorithms for the re-treatment with viscosupplementation in patients suffering from knee osteoarthritis
Henrotin, Yves ULiege; Richette, Pascal; Raman, R et al

in Osteoarthritis and Cartilage (2017), 25

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See detailMaking Sense Out of Pulsating Pre-ELM and ELM White Dwarfs
Fontaine, Gilles; Istrate, Alina; Gianninas, Alexandros et al

in Astronomical Society of the Pacific Conference Series (2017), 509

We present a unified view of pulsations in both pre-ELM and ELM white dwarfs within the framework of state-of-the-art binary evolution calculations that take into account the combined effects of diffusion ... [more ▼]

We present a unified view of pulsations in both pre-ELM and ELM white dwarfs within the framework of state-of-the-art binary evolution calculations that take into account the combined effects of diffusion and rotational mixing. We find that rotational mixing is able to maintain against settling a sufficient amount of helium in the envelope in order to fuel pulsations through He II-He III ionization on the pre-ELM branch of the evolutionary track in the spectroscopic HR diagram. By the time such a low-mass white dwarf enters the ZZ Ceti instability strip on the cooling branch, settling has taken over rotational mixing and produced a pure H envelope. Such a star then pulsates again, but, this time, as a DA white dwarf of the ZZ Ceti type. [less ▲]

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See detailThe theoretical instability strip of V777 Her white dwarfs
Van Grootel, Valérie ULiege; Fontaine, Gilles; Brassard, Pierre et al

in Astronomical Society of the Pacific Conference Series (2017), 509

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See detailEarthquake imprints on a lacustrine deltaic system: Example of the Kürk Delta along the East Anatolian Fault (Turkey)
Hubert, Aurelia ULiege; El Ouahabi, Meriam ULiege; Moreno, David et al

in Geophysical Research Abstracts (2017), 19

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See detailEffects of the soil pore network architecture on the soil’s physical functionnalities
Smet, Sarah ULiege; Beckers, Eléonore ULiege; Léonard, Angélique ULiege et al

in Geophysical Research Abstracts (2017), 19

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See detailEncounters of the third kind: antonyms and tertium
Steffens, Marie ULiege

in Studies van de BKL - Travaux du CBL - Papers of the LSB (2017), 11

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See detailCan Autonomous Vehicles Reduce Car Mobility? Evidence from a Stated Adaptation Experiment in Belgium
Cools, Mario ULiege; Rongy, Caroline; Limbourg, Sabine ULiege

in Transportation Research Board Annual Meeting. Compendium of Papers (2017)

From literature, it is clear that the discussion about the potential benefits and drawbacks of autonomous vehicles is not finished. In order to provide insight into this discussion, this paper ... [more ▼]

From literature, it is clear that the discussion about the potential benefits and drawbacks of autonomous vehicles is not finished. In order to provide insight into this discussion, this paper investigates different attitudes with respect to different key factors for the deployment of system of autonomous taxis. To this end, a stated adaptation experiment was carried out in Belgium in March 2016. To investigate which factors influence the variables of interest, i.e. (i) the number of minutes one is prepared to wait before an autonomous taxi picks up the person, (ii) the ownership of a private car when autonomous taxis are available, (iii) the willigness to share an autonomous taxi, (iv) the permittance for the autonomous vehicle to take a detour when it is beneficial for the society, and (v) the willigness to share your private agenda to ensure a timely autonomous taxi, different regression models are constructed. The results show that the considered explanatory factors only capture a small part of the variability five variables of interest. This is as signal that market segmentation might be very challenging. Besides, this is an indication that a broader range of factors should be included such as life-style factors and psychological constructs. Finally, this acknowledges the need for some skepticism with regard to the potential benefits of autonomous vehicles. The results are interesting for providing realistic boundaries and cross-classification in further simulation studies that look at the benefits of autonomous vehicles. [less ▲]

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See detailAnalyse des conséquences cliniques de la sarcopénie: une revue systématique et méta-analyse.
Beaudart, Charlotte ULiege; Zaaria, M.; Pasleau, F. et al

in L'année Gérontologique (2017), 31(1), 18

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See detailRole of nutrition and physical exercise in maintaining intrinsic capacity
Bruyère, Olivier ULiege

in Osteoporosis International (2017), 28(S1), 84

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See detailL'étude SarcoPhAge: devenir des sujets sarcopéniques après 2 ans de suivi.
Beaudart, Charlotte ULiege; Locquet, Médéa ULiege; Reginster, Jean-Yves ULiege et al

in L'Année Gérontologique (2017), 31(1), 42

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See detailConnected devices in musculo-skeletal health
Bruyère, Olivier ULiege

in Osteoporosis International (2017), 28(S1), 88

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See detailHealth outcomes of sarcopenia: a systematic review and metaanalysis.
Beaudart, Charlotte ULiege; Zaaria, M.; Pasleau, Françoise ULiege et al

in Osteoporosis International (2017), 28 Suppl 1

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See detailHealth outcomes of sarcopenia: a systematic review and meta-analysis.
Zaaria, M.; Pasleau, Françoise ULiege; Reginster, Jean-Yves ULiege et al

in Journal of Frailty & Aging (2017), 6 Suppl 1

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See detailSurvey of ESCEO algorithm: methodology and results
Bruyère, Olivier ULiege

in Osteoporosis International (2017), 28(S1), 635

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See detailCloud architecture for digital phenotyping and automation
Debauche, Olivier ULiege; Mahmoudi, Saïd; Manneback, Pierre et al

in IEEE Cloud Computing (2017)

Digital phenotyping presents a very important tool for scientists to measure with high accuracy the effects of external phenomena on plant development. Plant phenotyping is mainly based on imaging ... [more ▼]

Digital phenotyping presents a very important tool for scientists to measure with high accuracy the effects of external phenomena on plant development. Plant phenotyping is mainly based on imaging techniques. However, the number of images and parameters used to store and treat these parameters are continuously growing. Consequently, the high-throughput of data and the need of specific treatment in real or near real-time requires a large quantity of resources. Moreover, the increasing amount of particular phenotyping case studies needs the development of specific application. Cloud architectures offers means to store a wide range of numerous data and host a large quantity of specific software to process these data. In this paper, we propose to match digital phenotyping need and cloud possibilities in a lambda cloud architecture in order to store and treat this important amount of data. We also propose a data platform allowing to host applications and access to the stored data within the lambda architecture. The present application platform allows to use several frameworks with a fine-grained resource use of the cluster. We develop then a case study in a controlled environment system (growth chamber) where we grow basil plants. [less ▲]

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See detailAttenuation measurements inside and at the output of a passive silencer equipped with parallel absorbing baffles
Kaiser, Xavier ULiege; Brandt, Sébastien; Meys, Benoît et al

in Proceedings of meetings on acoustics (2017), 30(030006 doi: 10.1121/2.0000600),

The mock-up of a great passive silencer used for noise attenuation in industrial applications has been designed and tested in laboratory. This mock-up consists of three metal casing containing the noise ... [more ▼]

The mock-up of a great passive silencer used for noise attenuation in industrial applications has been designed and tested in laboratory. This mock-up consists of three metal casing containing the noise source and several removable rails and supports, allowing the test of different configurations of parallel absorbing baffles. The output of the silencer radiates in an anechoic chamber in order to simulate free-field conditions. The acoustic attenuation has been measured not only at the output, but also inside the silencer, with a mobile microphone located at several positions along the axis. Also, the tested configurations include three types of absorbing pillows and several geometrical arrangements. The results show that the maximum insertion loss (dB) measured at the output of the silencer corresponds to frequencies between 800Hz and 2.5kHz and its value strongly depends on the air gaps between baffles. The measurements with the mobile microphone show a linear decrease of the sound pressure level with the distance along the axis (mainly between 100Hz and 1kHz), which corresponds to the depth of absorbing material involved in the attenuation. Finally, a comparison with a real-scale silencer shows a fairly good correspondence. [less ▲]

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See detailMonitoring Changes in the Volatile Profile of Aging Human Blood
Dubois, Lena ULiege; Perrault, Katelynn ULiege; Stefanuto, Pierre-Hugues ULiege et al

in Forensic Science International (2017), 277

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See detailEnhanced Chemical Profiling of Human Decomposition in a Case Study
Dubois, Lena ULiege; Perrault, Katelynn ULiege; Stefanuto, Pierre-Hugues ULiege et al

in Forensic Science International (2017), 277

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See detailA Minimally-Invasive Internal Gas Reservoir Monitoring Method for Postmortem Examinations
Perrault, Katelynn ULiege; Stefanuto, Pierre-Hugues ULiege; Dubois, Lena ULiege et al

in Forensic Science International (2017), 277

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See detail"Acute kidney dysfunction with no rejection (ADNR)" is associated with poor outcomes in kidney transplant recipients
PAQUOT, Francois ULiege; Pottel, Hans; BONVOISIN, Catherine ULiege et al

in Transplant International (2017), 30((Suppl. 2)), 558

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See detailGlobally Induced Forest: A Prepruning Compression Scheme
Begon, Jean-Michel ULiege; Joly, Arnaud; Geurts, Pierre ULiege

in Proceedings of Machine Learning Research (2017), 70

Tree-based ensemble models are heavy memory- wise. An undesired state of affairs consider- ing nowadays datasets, memory-constrained environment and fitting/prediction times. In this paper, we propose the ... [more ▼]

Tree-based ensemble models are heavy memory- wise. An undesired state of affairs consider- ing nowadays datasets, memory-constrained environment and fitting/prediction times. In this paper, we propose the Globally Induced Forest (GIF) to remedy this problem. GIF is a fast prepruning approach to build lightweight ensembles by iteratively deepening the current forest. It mixes local and global optimizations to produce accurate predictions under memory constraints in reasonable time. We show that the proposed method is more than competitive with standard tree-based ensembles under corresponding constraints, and can sometimes even surpass much larger models. [less ▲]

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See detailDFG en population saine africaine : comparaison des performances de 11 équations d’estimation à marquer unique ou combinés, avec et sans facteur ethnique
yayo, Eric; Yao-Papo, E; Gnionsahé, A et al

in Néphrologie & Thérapeutique (2017), 13(5), 277

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See detailAssessing Inter- and Intramolecular Continuous-Flow Strategies towards Methylphenidate Hydrochloride
Gerardy, Romaric ULiege; Winter, Marc; Vizza, Alessandra et al

in Reaction Chemistry and Engineering (2017), 2(2), 149-158

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See detailBeing Moroccan abroad. Objects and everyday practices in women subjectivation.
Mescoli, Elsa ULiege

in International Review of Social Research (2017)

Objects and practices used and performed daily, play a central role in the definition of the self, and migration paths, meant both in a personal and in a collective sense, determine complex dynamics which ... [more ▼]

Objects and practices used and performed daily, play a central role in the definition of the self, and migration paths, meant both in a personal and in a collective sense, determine complex dynamics which involve them directly. Starting from De Certeau's analysis of everyday life [1980], my research focuses on Moroccan women living in Milan's suburbs, and it aims at studying how they make themselves and the place where they live, after migration, through materiality, moving in peculiar ways among what new local context (with its mass production and wished standardization of habits) and origin country (where what is perceived as "traditional" constantly meets the global dimension of goods and practices) impose. The murmuring of everyday practices and the words of the objects involved talk about women who perform and use them in ways that lead a complex reflection on the definition of a proper Moroccan "style" [Gell, 1998]: if we can say that a person is made of material objects which determine an induction of its own agency, of biographical history and of collective memory, equally we might state that these objects interlace among each other and define different manners of being Moroccan, and of being it abroad. [less ▲]

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See detailIntérêt de nouveaux marqueurs biologiques dans l’évaluation de la sarcopénie en dialyse.
DELANAYE, Pierre ULiege; QUINONEZ, Kevin ULiege; Buckinx, Fanny ULiege et al

in Néphrologie & Thérapeutique (2017), 13(5), 269

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See detailMesure de la force de préhension chez le patient dialysé: quand l'effectuer?
DELANAYE, Pierre ULiege; QUINONEZ, Kevin ULiege; Buckinx, Fanny ULiege et al

in Néphrologie & Thérapeutique (2017), 13(5), 296

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See detailConcept de fragilité chez le patient hémodialysé
QUINONEZ, Kevin ULiege; Buckinx, Fanny ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Néphrologie & Thérapeutique (2017), 13(5), 296

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See detailObserving surface circulation of the Western Mediterranean Basin with satellite imagery
Karimova, Svetlana ULiege

in The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2017), XLII-3/W2

In this article, the benefits of using satellite imagery of different types (namely thermal infrared, visible-range, and synthetic aperture radar (SAR) images) for observing surface circulation of marine ... [more ▼]

In this article, the benefits of using satellite imagery of different types (namely thermal infrared, visible-range, and synthetic aperture radar (SAR) images) for observing surface circulation of marine basins are being discussed. As a region of interest, we use the Western Mediterranean Basin. At first, the areas with sharpest thermal and chlorophyll-a gradients within the region of interest were defined on a seasonal base using the data provided by Aqua Moderate Resolution Imaging Spectrometer (MODIS). After that, mesoscale eddies were detected using different sea surface temperature (SST) products and, finally, submesoscale vortices were observed with Envisat Advanced SAR imagery. Thus found locations of eddies were compared with locations of the sharpest fronts discovered in the first part of the study, which showed that the biggest, mostly anticyclonic, eddies tended to correspond to locations of main surface currents; smaller cyclonic eddies were mostly attributed to thermal fronts, while submesoscale eddies were distributed quite homogeneous. The observations performed in that way revealed quite prominent basin-, meso- and submesoscale eddy activity in the region of interest. Additionally, significant seasonal variability in the type of surface water stirring was noted. Thus, the maximum of both meso- and submesoscale eddy activity seems to happen during the warm season, while during winter, presumably due to low Richardson numbers typical for the upper water layer, the turbulent features are still undeveloped and of the smaller spatial scale than during the warm period of year. [less ▲]

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See detailVirtual Trials of the NICE-SUGAR Protocol: The Impact on Performance of Protocol and Protocol Compliance
Uyttendaele, Vincent ULiege; Dickson, Jennifer L.; Shaw, Geoffrey M. et al

in IFAC-PapersOnLine (2017), 50(1), 6672-6677

Hypoglycaemia, hyperglycaemia and blood glucose (BG) variability are associated with worsened outcomes in critical care. However, NICE-SUGAR trial showed no clinical benefit from intensive insulin therapy ... [more ▼]

Hypoglycaemia, hyperglycaemia and blood glucose (BG) variability are associated with worsened outcomes in critical care. However, NICE-SUGAR trial showed no clinical benefit from intensive insulin therapy. This study compares the table-based NICE-SUGAR and model-based STAR protocols to assess their relative capability to achieve safe, effective control for all patients. Validated virtual patients (n=443) were used to simulate glycaemic outcomes of the NICE-SUGAR and STAR protocols. Key outcomes evaluate tightness and safety of control for all patients: %BG in 80–144 mg/dL range (PTR); Per-Patient Mean BG (PPM_BG); and Incidence of Hypoglycaemia (BG<40 mg/dL). These metrics determine performance overall, for each patient, and safety. Results are assessed for NICE-SUGAR measuring per-protocol (~24/day) and at reported average rate (~3-hourly; ~8/day). STAR measures 1-3-hourly, averaging 12/day. Per-protocol, STAR provided tight control, with higher PTR (90.7% vs. 78.3%) and tighter median [IQR] PPM_BG (112[106-119] vs. 117[106–137] mg/dL), and greater safety from hypoglycaemia (5 (1%) vs. 10 patients (2.5%)) compared to NICE-SUGAR simulations as per protocol. The 5-95th percentile range PPM_BG for NICE-SUGAR (97–185 mg/dL) showed ~5% of NICE-SUGAR patients had mean BG above 180mg/dL matching clinically reported performance. STAR’s 5th-90th PPM_BG percentile range was (97–146 mg/dL). Measuring as recorded clinically, NICE-SUGAR had PTR of 77%, PPM_BG of 122 [110-140] mg/dL and 24(6%) of patients experienced hypoglycaemia. These results match clinically reported values well (mean BG 115 vs. 118 mg/dL clinically vs. simulation, clinically 7% of patients had a hypoglycaemic event). Glycaemic control protocols need to be both safe and effective for all patients before potential clinical benefits can be assessed. NICE-SUGAR clinical results do not match results expected from their protocol, and show reduced safety and performance in comparison to STAR. [less ▲]

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See detailÉtude du degré de satisfaction de patients lombalgiques au sujet du site internet éducatif « Retrain Pain »
Demoulin, Christophe ULiege; Blanc, A.; Wolfs, Sébastien ULiege et al

in Revue du Rhumatisme (2016, December), 83S

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See detailEfficacité d’un programme de rééducation active pluridisciplinaire du dos : suivi de 812 patients lombalgiques chroniques
Mahieu, Geneviève; Boogaerts, M.; Tordeurs, D. et al

in Revue du Rhumatisme (2016, December), 83S

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See detailHost Interleukin 6 and Indoleamine 2,3 Dioxygenase Regulate Inflammation in the Brain during Graft Versus Host Disease
Belle, Ludovic ULiege; Koester, E; Hansen, E et al

in Blood (2016, December), 128

Graft versus host disease (GVHD) commonly induces pathological damage in peripheral target organs such as the skin, liver and gastrointestinal tract leading to well characterized organ-specific clinical ... [more ▼]

Graft versus host disease (GVHD) commonly induces pathological damage in peripheral target organs such as the skin, liver and gastrointestinal tract leading to well characterized organ-specific clinical manifestations. A number of studies, however, have shown that patients with GVHD can also have behavioral and mood alterations that can affect overall cognitive function and lead to significant impairments in quality of life. The extent to which GVHD contributes to cognitive dysfunction and induces inflammation within the central nervous system (CNS), however, has not been critically examined. To address this question, we conducted studies using two well-defined murine GVHD models [C57BL/6(H-2b)→Balb/c (H-2d) and B10.BR(H-2k)→B6 (H-2b)]. We observed that there was a significant increase in the number of donor-derived CD4+ and CD8+ T cells in the brains of GVHD recipients early (days 7 -14) and late (day 42) post transplantation compared to BM controls. Histological studies revealed activated microglial cells and CD3+ T cell infiltration in the periventricular regions of brains in GVHD recipients that were not present in BM animals. Real time q-PCR analysis also demonstrated significant increases in IFN-γ, TNF-α, and IL-6 mRNA expression indicative of a proinflammatory state. Notably, GVHD animals exhibited behavioral changes in the forced swim test and elevated plus maze which are validated assays of stress coping and anxiety, respectively. Since IL-6, in particular, plays a pivotal role in GVHD pathogenesis in murine models and humans, we examined whether blockade of IL-6 signaling altered neuroinflammation. Animals treated with an anti-IL-6R antibody had a significant reduction in the number of donor-derived CD4+ and CD8+T cells in the brain compared to isotype control-treated mice. Anti-IL-6R treatment of GVHD mice also resulted in significant reductions in IFN-γ, TNF-α, and IL-6 mRNA and normalized behavior in the forced swim test, indicative of a decreased inflammatory response. Since IL-6 is produced by a wide variety of cells, including microglial and T cells, both donor and recipient cells have the potential to modulate GVHD severity within the CNS. To define whether donor or host IL-6 production was most critical for inducing neuroinflammation, experiments were conducted employing IL-6-/- mice as either donors or recipients. Whereas the absence of IL-6 in donor-derived cells had no impact on the degree of inflammation within the CNS, recipient animals that lacked IL-6 had a significant decrease in the number of donor-derived T cells which accumulated in the brain as well as a marked reduction in inflammatory cytokines, indicating that host IL-6 production was critical. To define the downstream pathways of IL-6-mediated CNS inflammation, we examined the role of indoleamine 2,3-dioxygenase (IDO) since IL-6 has been shown to upregulate IDO-1 expression under inflammatory conditions. We observed that IDO-1 mRNA levels were significantly increased in the brains of GVHD animals, and that blockade of IL-6 signaling resulted in a marked decrease in IDO mRNA levels. Additionally, transplantation studies using IDO-/- mice revealed that host, but not donor, IDO production was required for maximal inflammatory effects. Serotoninergic projections to the prefrontal cortex (PFC), in particular, are sensitive to inflammation and contribute to stress coping behavior. Therefore, to further interrogate this pathway, we performed quantitative mass spectrometry of brain extracts from the PFC. We found that tryptophan and 5HT concentrations were not different between BM and GVHD groups. However, there was an increase in the IDO product, kynurenic acid, in GVHD recipients consistent with an increase in brain IDO expression. To provide additional support for the premise that IL-6 effects were mediated through the IDO pathway, recipient mice were treated with either 1-methyltryptophan (1-MT), a completive inhibitor of IDO, or a vehicle control. GVHD mice treated with 1-MT had decreased accumulation of T cells in the brain and normal behavior in the forced swim test, demonstrating that inhibition of IDO abrogated CNS inflammation and behavioral changes in the presence of intact IL-6 signaling. In summary, these studies demonstrate that host IL-6 and IDO regulate inflammation and adversely impact behavioral function within the brain during GVHD through the tryptophan metabolic pathway. [less ▲]

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See detailSommeil, éveil et cognition au cours du temps
Vandewalle, Gilles ULiege

in Bulletin de la Société Royale des Sciences de Liège (2016, November 25)

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See detailIn Vivo Preclinical Molecular Imaging: From the Laboratory Bench to the Patient.
Plenevaux, Alain ULiege

in Pharmaceuticals (2016, November 18), 9(4), 73

Preclinical molecular imaging plays a key role in the study of diseases and the development, evaluation, andvalidation of novel treatment and diagnostic techniques. The actual aim is to facilitate the ... [more ▼]

Preclinical molecular imaging plays a key role in the study of diseases and the development, evaluation, andvalidation of novel treatment and diagnostic techniques. The actual aim is to facilitate the translation of innovative therapies and diagnostic agents into patients by providing in vivo proof-of-principle data in animal models of diseases and accordingly match some of the legal requirements before human clinical trials. The real power of preclinical imaging stems from the fact that in vivo data are non-invasively collected, thus making longitudinal studies possible. The evolution of the disease or the actual impact of innovative treatments can be evaluated in the same animal over a long period of time. The major modalities used in preclinical molecular imaging (all present in our laboratory) are the positron emission tomography (microPET), the X-ray tomodensitometry (microCT) and the magnetic resonance imaging (microMRI). The GIGA-CRC In vivo Imaging at ULg is a multidisciplinary laboratory which relies on a medical cyclotron for radioisotope productions, a radiochemistry unit for the development of new radiopharmaceuticals and process automation, a GMP unit for radiopharmaceutical productions, a preclinical imaging unit and a clinical imagingplatform (with MRI, PET, EEG, TMS, . . . ). All expertise and qualified staff are present on site. Our laboratory has all necessary permission and approval for radiopharmaceutical productions and human clinical trials. During this presentation, we will take as an example the development of the first SV2A radioligand [18F]UCB-H (a-b) to illustrate how we can bring new ideas from the laboratory bench to the patient (Bretin, F., et al. Eur. J. Nucl. Med. Mol. Imaging Res. 2013, 3, 35; Warnock, G., et al. J. Nucl. Med. 2014, 55, 1336–1341). [less ▲]

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See detailExcited hyperons of the N = 2 band in the 1/Nc expansion
Stancu, Floarea ULiege

in Bled Workshops in Physics (2016, November), 17(1), 25-31

The spectrum of excited baryons in the $N$ = 2 band is reanalyzed in the $1/N_c$ expansion method, with emphasis on hyperons. Predictions are made for the classification of these excited baryons into SU(3 ... [more ▼]

The spectrum of excited baryons in the $N$ = 2 band is reanalyzed in the $1/N_c$ expansion method, with emphasis on hyperons. Predictions are made for the classification of these excited baryons into SU(3) singlets, octets and decuplets. [less ▲]

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See detailEfficient Computation of the Minimum of Shape Quality Measures on Curvilinear Finite Elements
Johnen, Amaury ULiege; Geuzaine, Christophe ULiege; Toulorge, Thomas et al

in Procedia Engineering (2016, November), 163

We present a method for computing robust shape quality measures defined for any order of finite elements. All type of elements are considered, including pyramids. The measures are defined as the minimum ... [more ▼]

We present a method for computing robust shape quality measures defined for any order of finite elements. All type of elements are considered, including pyramids. The measures are defined as the minimum of the pointwise quality of curved elements. The computation of the minimum, based on previous work presented by Johnen et al. (2013) [1] and [2], is very efficient. The key feature is to expand polynomial quantities into Bézier bases which allows to compute sharp bounds on the minimum of the pointwise quality measures. [less ▲]

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See detailDevices for less invasive surfactant therapy: a manikin study
RIGO, Vincent ULiege; Debauche, Christian; Maton, Pierre et al

in European Journal of Pediatrics (2016, November), 175(11), 1756

Background: “Less invasive surfactant therapy” (LIST), or tracheal instillation of surfactant through a small catheter in spontaneously breathing infants, is gaining popularity. Different catheters are ... [more ▼]

Background: “Less invasive surfactant therapy” (LIST), or tracheal instillation of surfactant through a small catheter in spontaneously breathing infants, is gaining popularity. Different catheters are currently used for this purpose: a nasogastric tube inserted with (LISA) or without (Take Care) Magill’s forceps, a 13 cm 16G adult angiocath (MIST), a 30 cm F4 angiography catheter (Stockholm). We developed a specific device by combining a F5 umbilical catheter and an intubation stylet (Liege). We aimed to compare those 5 devices using INSURE as a reference. Methods: 20 neonatologists from 4 institutions supporting different surfactant instillation policies intubated 2 manikin heads with the 5 catheters and an endotracheal tube in a predetermined random sequence. Water was flushed trough the catheter. Video review provided times between laryngoscope (T1) or catheter insertion (T2) in the mouth and water flowing from the trachea. Participants gave an ease of use score (range: 1-9) for each catheter. Results: Procedural times were longer with the Take Care method and shorter with the Liège device (Table). Failure rates were higher for LIST procedures than for INSURE. Take Care and LISA were rated as more difficult, while Liège, Stockholm and INSURE were considered easier. Conclusions: LIST procedures remain difficult, even on a manikin. The choice of catheter is important. A device combining the rigidity of a stylet with the soft distal end of an umbilical catheter is associated with procedures of shorter duration and is considered easier by neonatologists. [less ▲]

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See detailCase report: Ovarian fibroma in a mare – Hormonal considerations
Ponthier, Jérôme ULiege; Salciccia, Alexandra ULiege; Parrilla Hernandez, Sonia ULiege et al

in Reproduction in Domestic Animals (2016, October 27), 51(supplement 2), 132

This report shows that, as in humans, AMH as well as steroids productions are low in case of ovarian fibroma, thus preserving normal cyclicity.

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See detailSMART POINT CLOUD: DEFINITION AND REMAINING CHALLENGES
Poux, Florent ULiege; Neuville, Romain ULiege; Hallot, Pierre ULiege et al

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2016, October 05), IV-2(W1), 119-127

Dealing with coloured point cloud acquired from terrestrial laser scanner, this paper identifies remaining challenges for a new data structure: the smart point cloud. This concept arises with the ... [more ▼]

Dealing with coloured point cloud acquired from terrestrial laser scanner, this paper identifies remaining challenges for a new data structure: the smart point cloud. This concept arises with the statement that massive and discretized spatial information from active remote sensing technology is often underused due to data mining limitations. The generalisation of point cloud data associated with the heterogeneity and temporality of such datasets is the main issue regarding structure, segmentation, classification, and interaction for an immediate understanding. We propose to use both point cloud properties and human knowledge through machine learning to rapidly extract pertinent information, using user-centered information (smart data) rather than raw data. A review of feature detection, machine learning frameworks and database systems indexed both for mining queries and data visualisation is studied. Based on existing approaches, we propose a new 3-block flexible framework around device expertise, analytic expertise and domain base reflexion. This contribution serves as the first step for the realisation of a comprehensive smart point cloud data structure [less ▲]

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See detailTowards a normalised 3D Geovisualisation : the viewpoint management
Neuville, Romain ULiege; Poux, Florent ULiege; Hallot, Pierre ULiege et al

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2016, October 05), IV-2(W1), 179-186

This paper deals with the viewpoint management in 3D environments considering an allocentric environment. The recent advances in computer sciences and the growing number of affordable remote sensors lead ... [more ▼]

This paper deals with the viewpoint management in 3D environments considering an allocentric environment. The recent advances in computer sciences and the growing number of affordable remote sensors lead to impressive improvements in the 3D visualisation. Despite some research relating to the analysis of visual variables used in 3D environments, we notice that it lacks a real standardisation of 3D representation rules. In this paper we study the “viewpoint” as being the first considered parameter for a normalised visualisation of 3D data. Unlike in a 2D environment, the viewing direction is not only fixed in a top down direction in 3D. A non-optimal camera location means a poor 3D representation in terms of relayed information. Based on this statement we propose a model based on the analysis of the computational display pixels that determines a viewpoint maximising the relayed information according to one kind of query. We developed an OpenGL prototype working on screen pixels that allows to determine the optimal camera location based on a screen pixels colour algorithm. The viewpoint management constitutes a first step towards a normalised 3D geovisualisation. [less ▲]

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See detailThe OD/OH Isotope Ratio in Comets 8P/Tuttle and C/2012 F6 (Lemmon)
Rousselot, Philippe; Jehin, Emmanuel ULiege; Hutsemekers, Damien ULiege et al

in Bulletin of the American Astronomical Society (2016, October 01), 48

The determination of isotopic ratios in solar system objects is an important source of information about their origin, especially for comets. Among these ratios the D/H is of particular importance because ... [more ▼]

The determination of isotopic ratios in solar system objects is an important source of information about their origin, especially for comets. Among these ratios the D/H is of particular importance because of its sensitivity to fractionation processes and physical environment, and the abundance of hydrogen in the solar system. The main molecule used to derive this ratio in comets is water. So far, apart water, only HCN has permitted to derive D/H ratio and not only upper limits.Most of the existing determinations of D/H in water molecules have been obtained by spectroscopic observations of water lines in the sub-mm or near infrared range [1,2]. So far only one measurement has been based on OD/OH emission lines radicals in the near-UV [3] and another one on the Lyman-alpha D emission [4]. In situ measurements have also been obtained in comets 1P/Halley and 67P/Churyumov-Gerasimenko using mass spectrometer [5,6,7,8].In this work we have used the OH and OD ultraviolet bands at 310 nm observed with the ESO 8-m Very Large Telescope feeding the Ultraviolet-Visual Echelle Spectrograph (UVES) for measuring the D/H ratio in comets 8P/Tuttle and C/2012 F6 (Lemmon). The OH and OD being the photodissociation products of H[SUB]2[/SUB]O and HDO such observations allow to derive D/H ratio for water molecules. This work constitutes an independant determination of the D/H ratios already published for these comets and based on observations performed in the sub-mm and near infrared range of H[SUB]2[/SUB]O and HDO lines. We present our modeling, data analysis and numerical values obtained for this ratio.[1] D. Bockelée-Morvan et al., 2015, SSR 197, 47-83 [2] N. Biver et al., 2016, A&A 589, id A78, 11p [3] D. Hutsemékers et al., 2008, A&A 490, L31 [4] H.A. Weaver et al., 2008, LPI Contributions 1405, 8216 [5] H. Balsiger, K. Altwegg, J. Geiss, 1995, JGR 100, 5827 [6] P. Eberhardt et al., 1995, A&A 302, 301 [7] R.H. Brown et al., 2012, PSS 60, 166 [8] K. Alwegg et al., 2015, Science 347, article id. 1261952 [less ▲]

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See detailSurvey for Ortho-to-Para Abundance Ratios (OPRs) of NH2 in Comets: Revisit to the Meaning of OPRs of Cometary Volatiles
Kawakita, Hideyo; Shinnaka, Yoshiharu; Jehin, Emmanuel ULiege et al

in Bulletin of the American Astronomical Society (2016, October 01), 48

Since molecules having identical protons can be classified into nuclear-spin isomers (e.g., ortho-H[SUB]2[/SUB]O and para-H[SUB]2[/SUB]O for water) and their inter-conversions by radiative and non ... [more ▼]

Since molecules having identical protons can be classified into nuclear-spin isomers (e.g., ortho-H[SUB]2[/SUB]O and para-H[SUB]2[/SUB]O for water) and their inter-conversions by radiative and non-destructive collisional processes are believed to be very slow, the ortho-to-para abundance ratios (OPRs) of cometary volatiles such as H[SUB]2[/SUB]O, NH[SUB]3[/SUB] and CH[SUB]4[/SUB] in coma have been considered as primordial characters of cometary molecules [1]. Those ratios are usually interpreted as nuclear-spin temperatures although the real meaning of OPRs is in strong debate. Recent progress in laboratory studies about nuclear-spin conversion in gas- and solid-phases [2,3] revealed short-time nuclear-spin conversions for water, and we have to reconsider the interpretation for observed OPRs of cometary volatiles. We have already performed the survey for OPRs of NH[SUB]2[/SUB] in more than 20 comets by large aperture telescopes with high-resolution spectrographs (UVES/VLT, HDS/Subaru, etc.) in the optical wavelength region [4]. The observed OPRs of ammonia estimated from OPRs of NH[SUB]2[/SUB], cluster around ~1.1 (cf. 1.0 as a high-temperature limit), indicative of ~30 K as nuclear-spin temperatures. We present our latest results for OPRs of cometary NH[SUB]2[/SUB] and discuss about the real meaning of OPRs of cometary ammonia, in relation to OPRs of water in cometary coma. Chemical processes in the inner coma may play an important role to achieve un-equilibrated OPRs of cometary volatiles in coma.This work was financially supported by MEXT Supported Program for the Strategic Research Foundation at Private Universities, 2014–2018 (No. S1411028) (HK) and by Graint-in-Aid for JSPS Fellows, 15J10864 (YS).References:[1] Mumma & Charnley, 2011, Annu. Rev. Astro. Astrophys. 49, 471.[2] Hama & Watanabe, 2013, Chem. Rev. 113, 8783.[3] Hama et al., 2008, Science 351, 6268.[4] Shinnaka et al., 2011, ApJ 729, 81. [less ▲]

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See detailOstéoblastes autologues (PREOB®) versus concentré de moelle autologue dans l’ostéonécrose de la tête fémorale : étude randomisée
HAUZEUR, Jean-Philippe ULiege; Tungouz, Michel; LECHANTEUR, Chantal ULiege et al

in Revue de Chirurgie Orthopédique et Traumatologie (2016, October), 102

In non-traumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow concentrate (BMC) containing mesenchymal stem cells (MSC) could delay ONFH progression and improve symptoms (Hernigou ... [more ▼]

In non-traumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow concentrate (BMC) containing mesenchymal stem cells (MSC) could delay ONFH progression and improve symptoms (Hernigou 2002, Gangji 2004). The next step was to assess the hypothesis that a population of autologous osteoblastic cells (OB) consisting in a more differentiated cell than MSC, could be more efficacious than BMC in early stages ON. [less ▲]

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See detailWhat are the optimal walking tests to assess disability progression?
Pierard, Sébastien ULiege; Van Droogenbroeck, Marc ULiege

in Multiple Sclerosis Journal (2016, September 16), 22(S3), 452-453

Background. Therapy success is assumed when there is no evidence of disease activity. Clues to show it include an MRI, the relapses history, questionnaires, and clinical measures to assess the disability ... [more ▼]

Background. Therapy success is assumed when there is no evidence of disease activity. Clues to show it include an MRI, the relapses history, questionnaires, and clinical measures to assess the disability progression. Especially gait analysis plays a major role as gait impairment is considered by patients as the most disabling symptom. Too often only the walking speed is measured. New technologies (eg GAIMS, see ECTRIMS 2012-15) measure many spatiotemporal gait parameters, even during long tests (\eg 6min, 500m), without equipping patients with markers or sensors. Moreover, various tests can be done, depending on the length and type of walk (comfortable pace --C--, as fast as possible --F--, tandem gait --T--). Objective. Determine if there is an advantage to perform various walking tests, and which test or combination of tests brings the higher amount of information about the patient state in a reasonable amount of acquisition time. Methods. The system GAIMS provided 434 recordings of the gait parameters of healthy people and 60 recordings of MS patients with EDSS<= 4. They performed 12 tests (25ft C+F+T each twice, 20m C+F+T, 100m C+F, 500m F). To assess the ability of these clinical outcome measures to detect disability progression, we evaluate the possibility of differentiating the persons below a given EDSS threshold (0.25) from those above it based only on the measured gait parameters. For individual tests, we use the classifier of Azrour (ESANN 2014). All subsets of the tests are also considered, by combining the individual classifiers and determining automatically the optimal relative importance of the tests with the linear support vector machine (SVM) technique. The ability to detect the disability progression is quantified by the performance (area under the ROC curve --AUC-- and the maximum achievable balanced accuracy --MBA--) of the corresponding classifiers. Results. The best test alone is the 500m F (note that the walking speed measured during it is the gait parameter best correlated with the EDSS). Combining several tests leads to a better performance. A performance (MBA=95.7%, AUC=0.983) close to the best achievable one can be obtained with 6 tests only (25ft C twice, 25tf F twice, 20m C, 20m T). Conclusions. The clinical gait analysis can help to detect disability progression. While considering different types of walking tests improves the ability of taking decisions, we showed that performing 6 tests for a total of 70.48m suffices. [less ▲]

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See detailModels of rotating stars constrained by asteroseismic measurements of red giants
Eggenberger, P.; Lagarde, N.; Miglio, A. et al

in Astronomische Nachrichten (2016, September 01), 337(8-9), 832-836

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and ... [more ▼]

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and internal properties of these stars. In particular, core rotation rates have been obtained for red-giant stars, which is of prime importance to progress in the modelling of the dynamical processes at work in stellar interiors. In this presentation, we discuss which constraints can be brought by these asteroseismic measurements on stellar models that include rotational effects. Similarly to the solar case, we show that an efficient mechanism is required for the transport of angular momentum in the radiative zones of red giants. The efficiency of this transport process can be determined by asteroseismic observations of red-giant stars. [less ▲]

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See detailValeurs de référence de débit de filtration glomérulaire en population noire-africaine
Yayo, E; Monnet, D; Attoungbré, M.-L. et al

in Néphrologie & Thérapeutique (2016, September), 12(5), 273

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See detailGait pattern of healthy old people for fast walking condition
GILLAIN, Sophie ULiege; Boutaayamou, Mohamed ULiege; Schwartz, Cédric ULiege et al

in Gerontechnology (2016, September)

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See detailAge-related changes in the modulation of attentional brain responses to sleep pressure at night
Schmidt, Christina ULiege; Reichert, Carolin; Maire, Micheline et al

in Journal of Sleep Research (2016, September)

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See detailGait pattern of healthy old people for dual task walking condition
GILLAIN, Sophie ULiege; Boutaayamou, Mohamed ULiege; Schwartz, Cédric ULiege et al

in Gerontechnology (2016, September)

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See detailHome blood pressure in kidney transplant recipients (Ktr) - Validity of different schedules of self-monitoring
SAINT-REMY, Annie ULiege; WEEKERS, Laurent ULiege; BONVOISIN, Catherine ULiege et al

in Journal of Hypertension (2016, September), 34(e supplement 2), 119

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See detailCompte rendu de l’atelier « Entretiens de stages »
Francois, Nathalie ULiege; Simons, Germain ULiege; Van Hoof, Florence ULiege

in Didactiques en Pratique (2016, September), 2

Cet article présente le compte rendu d'un atelier portant sur les entretiens de stages dans l'enseignement. Lors de l'atelier, les participants étaient invités à analyser des extraits d'entretiens entre ... [more ▼]

Cet article présente le compte rendu d'un atelier portant sur les entretiens de stages dans l'enseignement. Lors de l'atelier, les participants étaient invités à analyser des extraits d'entretiens entre un futur enseignant, son maitre de stage et son formateur. La discussion collective a permis ensuite de mettre en exergue des éléments potentiellement porteurs et facilitateurs dans ces situations d'entretiens. [less ▲]

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See detailUniversité d'été du Cifen 2015 : insertion professionnelle et parcours enseignants. Mise en perspective et présentation du programme de la journée
Simons, Germain ULiege

in Didactiques en Pratique (2016, September), 2

Cette communication ouvrait l'Université d'été 2015 du Cifen. La thématique du colloque : "insertion professionnelle et parcours enseignants" y fut brièvement présentée, de même que les questions qui ... [more ▼]

Cette communication ouvrait l'Université d'été 2015 du Cifen. La thématique du colloque : "insertion professionnelle et parcours enseignants" y fut brièvement présentée, de même que les questions qui allaient baliser cette journée d'études. Ensuite le programme de la journée fut rappelé aux participants. [less ▲]

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See detailSystematic Downstream Development, Optimization and Equipment Design for Biobased Products and Processes
Bednarz, Andreas; Rüngeler, Bettina; Scherübel, Peter et al

in Chemie Ingenieur Technik (2016, September), 88(9), 1375-1376

Biobased synthesis poses specific challenges due to the properties of raw materials, intermediates, and products. They are induced by the higher oxygen content as compared to fossil feedstock. Thus low ... [more ▼]

Biobased synthesis poses specific challenges due to the properties of raw materials, intermediates, and products. They are induced by the higher oxygen content as compared to fossil feedstock. Thus low vapor pressure, higher viscosity, low concentration in aqueous solution will require new, preferably liquid-based downstream processes, for which many different options can be proposed. A systematic method to evaluate such a multitude of options based on cascaded option trees is presented, which combines representation and evaluation of options on a suitably chosen level of detail. Criteria, which have to be fulfilled by the options, are flexibly evaluated ranging from input of experts to detailed simulation. Clear visualization also allows transparent communication of results to members of interdisciplinary teams and project partners. The method is demonstrated for extractive separation steps including real-world problems encountered. This includes high viscosities, presence of solids or microorganisms leading to crud formation, and optimization of process conditions solving the conflicting challenges balancing e.g. between low toxicity to microorganisms and process efficiency. [less ▲]

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See detailApproche stratégique de formation du personnel local au sein des ONG internationales dans un contexte incertain : cas du Burundi
Hakizumukama, Alexis ULiege

in Actes des Rencontres Internationales sur la Diversité (2016, September)

The human resources management issues is a major challenge for the current and future international organizations, especially those of the non merchant sector, as the environmental context in which they ... [more ▼]

The human resources management issues is a major challenge for the current and future international organizations, especially those of the non merchant sector, as the environmental context in which they operate is changing more and more quickly. Thus, beyond the mobilization and the gradual professionalization of volunteers to adapt their contribution to the missions of NGOs, these organizations are also experiencing a real need for personnel able to adapt without too much difficulty, the complexity of the local context whose evolution often proves unpredictable. But this labor, multiple and high skills, is often scarce on the local labor market. This finding essentially explains the presence of expatriates who work daily alongside local employees who may be employees and volunteers, and whose management requires a sufficiently coherent strategy with organizational goals and interests of these stakeholders. HRM strategy implementation within the subsidiaries shall submit their leaders to multiple challenges brought by a set of actors focused on different and even divergent interests. The model and HRM practices in any organization, reflect the dominant HRM strategy. During our research, we pay special attention to the evolution of HRM models (Pichault and Nizet, 2013) and strategy implemented in the training of local personnel by subsidiaries studied by relying on the theory of social regulation (Reynaud, 1997, 1999). The conclusions of our work indicate that the development of HRM strategy following a joint regulatory process appears best suited to international NGOs working in uncertain environment. [less ▲]

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See detailSatellite Formation Control Using Continuous Adaptive Sliding Mode Controller
Cho, Hancheol ULiege; Kerschen, Gaëtan ULiege

in AIAA/AAS Astrodynamics Specialist Conference (2016, September)

The focus of this study is on the development of a robust controller with a simple gain adaptation for satellite formation control. The complete nonlinear dynamics of the motion of the follower satellite ... [more ▼]

The focus of this study is on the development of a robust controller with a simple gain adaptation for satellite formation control. The complete nonlinear dynamics of the motion of the follower satellite relative to the leader satellite is considered and the rigorous proof for the stability of the controlled formation system is given in the presence of unknown external disturbances and unknown mass of the follower satellite. Although the controller design is based on the concept of sliding mode control, the proposed control strategy is free from chattering and guarantees a finite-time convergence of the controlled system to the target area. Furthermore, a simple adaptive law to automatically update the control gain is suggested that does not require a priori knowledge of the uncertainties of the system. In addition, to guarantee the robustness from the beginning and to improve the transient performance, a new sliding surface is also constructed. Numerical simulations are carried out to demonstrate the effectiveness of the proposed adaptive controller to maintain a desired formation configuration by compensating for the initial offset errors and external disturbance effects including gravitational perturbations and atmospheric drag. [less ▲]

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See detailThe risk of subsequent osteoporotic fractures is decreased in patients experiencing fracture while on denosumab.
Kendler, D.L.; Chines, A.; Brandi, M.L. et al

in Arthritis and Rheumatism (2016, September), 68S10

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