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See detailPrevalence of vitamin D inadequacy in european women aged over 80 years
Bruyère, Olivier ULg; Slomian, Justine ULg; Beaudart, Charlotte ULg et al

in Osteoporosis International (2014), 25(2), 196

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See detailReaching the 1% accuracy level on stellar mass and radius determinations from asteroseismology
Van Grootel, Valérie ULg; Charpinet, Stephane; Fontaine, Gilles et al

in Proceedings of the International Astronomical Union (2014), 301

Asteroseismic modeling of subdwarf B (sdB) stars provides measurements of their fundamental parameters with a very good precision; in particular, the masses and radii deter- mined from asteroseismology ... [more ▼]

Asteroseismic modeling of subdwarf B (sdB) stars provides measurements of their fundamental parameters with a very good precision; in particular, the masses and radii deter- mined from asteroseismology are found to typically reach a precision of 1% containing various uncertainties associated with their inner structure and the underlying microphysics (composition and transition zones profiles, nuclear reaction rates, etc.). Therefore, the question of the accuracy of the stellar parameters derived by asteroseismology is legitimate. We present here the seismic modeling of the pulsating sdB star in the eclipsing binary PG 1336-018, for which the mass and the radius are independently and precisely known from the modeling of the reflection/irradiation effect and the eclipses observed in the light curve. This allows us to quantitatively evaluate the reliability of the seismic method and test the impact of uncertainties in our stellar models on the derived parameters. We conclude that the sdB star parameters inferred from asteroseismology are precise, accurate, and robust against model uncertainties. [less ▲]

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See detailPhotocatalytic degradation of water pollutants with visible light-sensitized TiO2 xerogels
Tasseroul, Ludivine ULg; Pirard, Sophie ULg; Lambert, Stéphanie ULg et al

in Récents Progrès en Génie des Procédés (2014), 106

To extend its photocatalytic activity to visible light, TiO2 has been doped in situ through the cogelation sol-gel proces with two dyes : free metal tetra(4-carboxyphenyl)porphyrin and nickel tetra(4 ... [more ▼]

To extend its photocatalytic activity to visible light, TiO2 has been doped in situ through the cogelation sol-gel proces with two dyes : free metal tetra(4-carboxyphenyl)porphyrin and nickel tetra(4-carboxyphenyl)porphyrin. DR and FT-IR spectroscopies have been performed to determine the interaction between porphyrins and TiO2. Cristallinity and specific surface area have been measured by XRD and N2 adsorption. The photoactivity of the doped TiO2 xerogels has been evaluated for p-nitrophenol (a model water pollutant) degradation under visible light and a kinetic study has been performed. The samples allow the degradation of 40% of p-nitrophenol in 6 h which makes them very promising for water decontamination under natural light. A kinetic study of p-nitrophenol degradation with the Ni-doped catalyst has shown that the best kinetic model involves one type of active site corresponding to the hole h+ of electron-hole pairs created at the TiO2 surface by light. The rate determining step consists of the surface reaction between adsorbed p-nitrophenol and adsorbed OH• radicals. [less ▲]

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See detailBioactive Intraocular Lens – A Strategy to Control Secondary Cataract
Huang, Yi-Shiang ULg; Bertrand, Virginie ULg; Bozukova, Dimitriya et al

in IFMBE Proceedings (2014), 41

Cataract is the opacity of the lens, causing impairment of vision or even blindness. Today, a surgery is still the only available treatment. The intraocular lens (IOL) is a polymer implant designed to ... [more ▼]

Cataract is the opacity of the lens, causing impairment of vision or even blindness. Today, a surgery is still the only available treatment. The intraocular lens (IOL) is a polymer implant designed to replace the natural lens in the cataract surgery. However, the bioinert materials could not satisfy the unmet need in the secondary cataract control. Posterior capsular opacification (PCO, or Secondary Cataract), characterized by a thick and cloudy layer of lens epithelial cells (LECs), is the most common postoperative complication. In our research, a bioactive molecule is immobilized onto the conventional acrylic hydrophilic polymer pHEMA (Poly(2-hydroxyethyl methacrylate)) using oxygen plasma treatment followed by deposition. The RGD peptide sequence, being well-known for its ability to promote cellular attachment by binding to integrin receptors, is designed to stimulate the adhesion of LECs on the IOL. Our data show the peptide immobilized biomaterial not only exhibits similar optical property, but also reveals enhanced biological properties in cell adhesion and cell morphology maintenance. By means of surface functionalization of IOL to stimulate LECs adhesion, the secondary cataract could be controlled. [less ▲]

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See detailBiochemical composition of cartilage with naturally occurring defects in the ovine femora-tibial joint
Matagne, A; Clegg, P; Tew, S et al

in Osteoporosis International (2014), 25(S2), 173

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See detailWhat does multiplication of tidemarks mean in the ovine femora-tibial joint ?
Pirson, R; Matagne, A; Nisolle, JF et al

in Osteoporosis International (2014), 25(S2), 172

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See detailToward redesigning the relationship between farming systems and biodiversity conservation
Brédart, David ULg; Denayer, Dorothée ULg; Mormont, Marc ULg

in Proceedings of the 11th European IFSA Symposium. Farming systems facing global challenges: capacities and strategies. (2014)

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See detailQuality of life benefits of knee arthroplasty for osteoarthritis
NEUPREZ, Audrey ULg; François, Garance ULg; KURTH, William ULg et al

in Osteoporosis International (2014), 25(2), 40

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See detailPrecision and Accuracy of Asteroseismology Applied to sdB stars Using the Forward Modeling Method
Charpinet, Stéphane; Van Grootel, Valérie ULg; Brassard, Pierre et al

in Astronomical Society of the Pacific Conference Series (2014), 481

Detailed seismic studies of hot B subdwarf (sdB) stars using the forward modeling approach provide measurements of their fundamental parameters at very interesting precisions. For instance, masses, radii ... [more ▼]

Detailed seismic studies of hot B subdwarf (sdB) stars using the forward modeling approach provide measurements of their fundamental parameters at very interesting precisions. For instance, masses, radii, and log g values derived this way are typically claimed at ∼ 1 − 2%, ∼ 0.5%, and ∼ 0.1 % precision, respectively. However, this method relies on still imperfect stellar models that contains various uncertainties associated with their inner structure and the underlying microphysics. A signature of these imperfections is the inability of current best-fit seismic models to reproduce all the observed oscillation frequencies at the precision of the observations. Therefore, the question of the accuracy (as opposed to the precision) of the derived parameters obtained from this approach is legitimate. Here, we revisit the question of precision and accuracy based on new, third generation, complete static models of sdB stars developed for asteroseismology and applied to the case of the eclipsing system PG 1336-018. This allows us to evaluate the reliability of the method and quantify the impact of various uncertainties in the stellar models on the derived stellar parameters. Finally, we discuss the intrinsic potential of asteroseismology for precise measurements of stellar parameters and show that we are far from having fully exploited this technique in terms of precision that can, in principle, be achieved. [less ▲]

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See detailObservational Asteroseismology of Hot Subdwarf Stars with the Mont4K/Kuiper Combination at the Steward Observatory Mount Bigelow Station
Fontaine, Gilles; Green, Elizabeth M.; Charpinet, Stéphane et al

in Astronomical Society of the Pacific Conference Series (2014), 481

In the last few years, we have carried out several extensive observational campaigns on pulsating hot subdwarf stars using the Mont4K CCD camera attached to the 1.55 m Kuiper Telescope on Mount Bigelow ... [more ▼]

In the last few years, we have carried out several extensive observational campaigns on pulsating hot subdwarf stars using the Mont4K CCD camera attached to the 1.55 m Kuiper Telescope on Mount Bigelow. The Mont4K is a joint partnership between the University of Arizona and Universite ́ de Montre ́al. It was designed and built at Steward Observatory. Using the Mont4K/Kuiper combination, we have so far, and among others, gathered high-sensitivity broadband light curves for PG 1219+534, PB8783, HS 0702+6043, and Feige 48. We report very briefly on some of the most interesting observational results that came out of these campaigns. [less ▲]

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See detailStrontium ranelate decreases the number of rapid radiological progressors from the first year in SEKOIA study
Chevalier, X; Richette, P; Bruyère, Olivier ULg et al

in Osteoarthritis and Cartilage (2014), 22(1), 461

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See detailEvaluation de la prévalence de la sarcopénie selon différents outils de diagnostic
Beaudart, Charlotte ULg; SLANGEN, Catherine ULg; Buckinx, Fanny ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(1), 42

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See detailModeling the hot subdwarf PB 8783 by asteroseismology
Van Grootel, Valérie ULg; Charpinet, Stephane; Fontaine, Gilles et al

in Astronomical Society of the Pacific Conference Series (2014), 481

We present the preliminary seismic modeling of one of the hottest and most compact subdwarf pulsators, PB 8783 (EO Ceti). This is a well observed hot subdwarf star, including a 78 d campaign in white ... [more ▼]

We present the preliminary seismic modeling of one of the hottest and most compact subdwarf pulsators, PB 8783 (EO Ceti). This is a well observed hot subdwarf star, including a 78 d campaign in white light photometry that we carried out at Mount Bigelow, Arizona, during the fall 2007. PB 8783 has also been observed at length in spectroscopy, revealing a spectrum highly contaminated by a main sequence companion. It is extremely difficult to disentangle the contribution of the two components and, as a consequence of this, the exact nature of the hot subdwarf (sdB or sdO star) is undetermined. We propose here to test the two hypotheses by asteroseismology. Although the sdB possibility cannot be excluded, the pulsation modes observed in PB 8783 are much better accommodated in the case of an sdO star. [less ▲]

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See detailMiddle Miocene climate and vegetation model reconstructions and their validation with the NECLIME database
François, Louis ULg; Henrot, Alexandra-Jane ULg; Utescher, Torsten et al

in Geophys. Res. Abstracts (2014), 16

The NECLIME database gathers data of the fossil flora recorded at many localities around the world at different times of the Miocene. François et al. (Palaeogeography, Palaeoclimatology, Palaeoecology ... [more ▼]

The NECLIME database gathers data of the fossil flora recorded at many localities around the world at different times of the Miocene. François et al. (Palaeogeography, Palaeoclimatology, Palaeoecology, 304, 359–378, 2011) have presented a new method for evaluating palaeoclimate model simulations from such fossil floras. In this method, palaeovegetation is simulated from climate model outputs, using a dynamic vegetation model. Model vegetation reconstruction is then compared to the vegetation cover indicated by the fossil flora record at the various localities, using a common classification of plant functional types (PFTs) in the data and the model. Here, we apply this method to test several published Middle Miocene climate simulations conducted with General Circulation Models of different complexity: (a) Planet Simulator, (b) FOAM-LMDZ4, (c) MPI-ESM, (d) CCSM3.0 and (4) CESM1.0. Corresponding palaeovegetation distributions are simulated with the CARAIB dynamic vegetation model, in which an upgraded vegetation classification involving 26 PFTs has been imple- mented. The NECLIME palaeoflora data from 154 localities distributed worldwide have been translated in terms of the presence/absence of these PFTs. A comparison of models and data is then undertaken globally and in selected regions of the world, using all available localities. The level of agreement varies among models, among PFTs and among regions. For instance, some models are able to produce tropical and subtropical PFTs in Europe consistently with the data, but the agreement for these PFTs may be much poorer in other parts of the world, such as in northeastern Eurasia. [less ▲]

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See detailEconomic evaluation of an osteoporosis screening campaign: using FRAX as a prescreening tool
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2014), 25(2), 38-39

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See detailMultiple myeloma cells instruct myeloid-derived suppressor cells to release pro-angiogenic cytokines
Binsfeld, Marilène ULg; Heusschen, Roy ULg; Lamour, Virginie et al

in Belgian Journal of Hematology (2014)

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See detailFacteurs de risque de chute chez des sujets résidant en maison de repos : étude prospective d'une durée de 2 ans
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(1), 164-165

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See detailMode Identification in Subdwarf B Stars from Multi-Wavelength Observations
Randall, Suzanna K; Fontaine, Gilles; Brassard, Pierre et al

in Astronomical Society of the Pacific Conference Series (2014), 481

We present several examples of partial mode identification for rapidly pulsating subdwarf B stars on the basis of multi-colour observations. Three targets (V391 Per, Balloon 090100001, and EC 11583−2708 ... [more ▼]

We present several examples of partial mode identification for rapidly pulsating subdwarf B stars on the basis of multi-colour observations. Three targets (V391 Per, Balloon 090100001, and EC 11583−2708) were analysed from multi-colour photometry, while studies were conducted from time-series spectrophotometry for two further stars (EC 20338−1925 and EC 01541−1409). In all cases, periodicities strongly dominating the frequency spectrum are associated with radial modes, indicating a clear hierarchy according to visibility when integrating over the visible disk of the star. [less ▲]

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See detailMicrostructures and Mechanical Properties of Stainless Steel AISI 316L Processed by Selective Laser Melting
Mertens, Anne ULg; Reginster, Sylvie ULg; Contrepois, Quentin et al

in Materials Science Forum (2014), 783-786 (2014)

In this study, samples of stainless steel AISI 316L have been processed by selective laser melting, a layer-by-layer near-net-shape process allowing for an economic production of complex parts. The ... [more ▼]

In this study, samples of stainless steel AISI 316L have been processed by selective laser melting, a layer-by-layer near-net-shape process allowing for an economic production of complex parts. The resulting microstructures have been characterised in details in order to reach a better understanding of the solidification and consolidation processes. The influence of the processing parameters on the mechanical properties was investigated by means of uniaxial tensile testing performed on samples produced with different main orientations with respect to the building direction. A strong anisotropy of the mechanical behaviour was thus interpreted in relation with the microstructures and the processing conditions. [less ▲]

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See detailExploration of unitization processes in episodic memory in Alzheimer's disease
Delhaye, Emma ULg; Salmon, Eric ULg; Bastin, Christine ULg

in Frontiers in Human Neuroscience (2014)

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See detailOn Interpreting g-Mode Period Spacings in sdB Stars
Charpinet, Stéphane; Brassard, Pierre; Van Grootel, Valérie ULg et al

in Astronomical Society of the Pacific Conference Series (2014), 481

Long period B subdwarf (sdB) pulsators, when observed from space with the satellites CoRoT and Kepler, show particularly rich g-mode oscillation spectra with often hundreds of frequencies. In many of ... [more ▼]

Long period B subdwarf (sdB) pulsators, when observed from space with the satellites CoRoT and Kepler, show particularly rich g-mode oscillation spectra with often hundreds of frequencies. In many of these pulsation spectra, regularities in the observed period distributions typical of high order g-modes in chemically homogeneous stars have been reported. This led to a claim that sdB stars could be much less chemically stratified than previously thought. In this paper, we show that such an interpretation is unfounded. We reinvestigate trapping effects on g-modes in sdB stars in view of current observations and show that ”standard” stratified models can also produce nearly quasi-constant period spacings in the low frequency range which are comparable to those observed in the g-mode spectra of these stars. [less ▲]

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See detailCould internet use be promising in health prevention and promotion in menopausal women ? A preliminary report
Slomian, Justine ULg; Streel, Sylvie ULg; Appleboom, G et al

in Osteoporosis International (2014), 25(2), 309

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See detailImpact of components of the metabolic syndrome on knee osteoarthritis progression in the SEKOIA study
Eymard, F; Edwards, M; Parsons, C et al

in Osteoarthritis and Cartilage (2014), 22(1), 376

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See detailFacteurs pronostiques de décès chez des sujets résidant en maison de repos suivis d'une manière prospective pendant une période de 2 ans
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(1), 73-74

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See detailArbitrary Lagrangian Eulerian simulations of stationary and non-stationary metal forming processes
Boman, Romain ULg; Ponthot, Jean-Philippe ULg

in AIP Conference Proceedings (2013, December 16), 1567

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See detailEvolution of the theoretical power spectrum of solar-like oscillations along the ascending phase on the red giant branch.
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, Kevin et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. An important question comes from the observation of mixed ... [more ▼]

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. An important question comes from the observation of mixed modes : When during the star’s ascension on the RGB are mixed-modes more likely to be detectable ? We follow the evolution of a star on the RGB and investigate the effect of its ascension on theoretical power spectrum. Equilibrium models (computed with the code ATON) represent four different stages of a star on the RGB. The mass of the star (1.5M") is in the typical mass range of stars observed by CoRoT and Kepler. We used a non-radial non-adiabatic code to compute the theoretical solar-like oscillations of these models. An important output of these calculations is the theoretical lifetimes of the modes. Then we computed the oscillation amplitudes through a stochastic excitation model. These computations allow us to draw theoretical power spectrum and discuss the possibility to observe mixed-modes at different evolutionary stages on the RGB. We found that structure modifications in a star ascending the RGB have an important impact on theoretical power spectrum of solar-like oscillations. Efficiencies of trapping and lifetimes of mixed modes are indeed strongly affected by this evolution. [less ▲]

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See detailWhite Dwarf Stars: A Brief Overview
Fontaine, Gilles; Brassard, Pierre; Charpinet, Stephane et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of ... [more ▼]

We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of stellar evolution for the vast majority of stars and, as such, bear the signatures of past events (such as mass-loss, mixing phases, loss and redistribution of angular momentum, and thermonuclear burning) that are of essential importance in the evolution of stars in general. In addition, white dwarf stars represent ideal testbeds for our understanding of matter under extreme conditions, and work on their constitutive physics (neutrino production rates, conductive and radiative opacities, interior liquid and solid equations of state, partially ionized and partially degenerate envelope equations of state, diffusion coefficients, line broadening mechanisms) is still being actively pursued. Given a set of constitutive physics, cooling white dwarfs can be used advantageously as cosmochronometers. Moreover, the field has been blessed by the existence of four distinct families of pulsating white dwarfs, each mapping a different evolutionary phase, and this allows the application of the asteroseismological method to probe and test their internal structure and evolutionary state. [less ▲]

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See detailIS ULTRA-SHORT COLD ISCHEMIA THE KEY TO ISCHEMIC CHOLANGIOPATHY AVOIDANCE IN DCD- LT?
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Cheham, Samir et al

in Transplant International (2013, December), 26(S2), 53-98

Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic ... [more ▼]

Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic cholangiopathy leading to graft loss. The authors retrospectively reviewed a single centre experience with DCD-LT in a 9-year period. Patients and Methods: 70 DCD-LT were performed from 2003 to November 2012. All DCD procedures were performed in operative rooms. Median donor age was 59 years. Most grafts were flushed with HTK solution. Allocation was centre-based. Median total DCD warm ischemia was 19.5 min. Mean follow-up was 36 months. No patient was lost to follow-up. Results: Median MELD score at LT was 15. Median cold ischemia was 235 min. Median peak AST was 1,162 U/L. Median peak bilirubin was 31.2 mg/dL. Patient and graft survivals were 92.8% and 91.3% at one year and 79% and 77.7% at 3 years, respectively. One graft was lost due to hepatic artery thrombosis. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Causes of death were malignancies in 8 cases. Discussion: In this series, DCD LT appears to provide results equal to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. [less ▲]

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See detailLes orthophonistes utilisent-ils les données issues de la recherche scientifique ? Analyse des pratiques afin d’ajuster la formation universitaire en Belgique
Durieux, Nancy ULg; Pasleau, Françoise ULg; Vandenput, Sandrina ULg et al

in Glossa (2013, December), 113

Une des missions fondamentales d’une formation universitaire est de permettre aux futurs professionnels d’identifier et de traiter efficacement les informations nécessaires aux prises de décisions parmi ... [more ▼]

Une des missions fondamentales d’une formation universitaire est de permettre aux futurs professionnels d’identifier et de traiter efficacement les informations nécessaires aux prises de décisions parmi un nombre toujours croissant de documents disponibles. Pour atteindre cet objectif, le recours à l’Evidence-Based Practice (EBP) s’avère une approche méthodologique permettant d’acquérir les savoirs et savoir-faire requis pour, notamment, la recherche d’informations probantes. L’EBP doit donc logiquement faire partie de la formation initiale des futurs orthophonistes en restant en adéquation avec les besoins et pratiques des professionnels. À cette fin, il est important d’identifier les questions que se posent les cliniciens dans leur pratique quotidienne, la manière dont ils trouvent des réponses et s’ils ont recours ou non aux données issues de la recherche scientifique. Une enquête a été lancée en mai 2012 auprès d’orthophonistes travaillant en Communauté française de Belgique. La présente communication exposera les principaux résultats, recueillis auprès de 410 orthophonistes, qui conduiront à des pistes d’action pour l’enseignement universitaire et la formation continue. [less ▲]

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See detailDONATION AFTER CIRCULATORY DEATH LIVER TRANSPLANTATION: IS DONOR AGE AN ISSUE?
DETRY, Olivier ULg; Ledinh, Heu; HONORE, Pierre ULg et al

in Transplant International (2013, December), 26(s2), 112-228

Background: Donation after circulatory death (DCD) donors > 55 years are usually not considered suitable for liver transplantation (LT). At our institute, age is not an absolute exclusion criterion to ... [more ▼]

Background: Donation after circulatory death (DCD) donors > 55 years are usually not considered suitable for liver transplantation (LT). At our institute, age is not an absolute exclusion criterion to refuse DCD liver grafts. We retrospectively compared the transplant outcome of patients receiving older DCD liver grafts to the younger ones. Methods: 70 DCD liver transplants have been performed from 2003 to 2012, which includes 32 liver grafts from younger donors <55y (group A), 20 between 56 and 69 years (group B), and 18 from older donors ≥70 years (group C). The three groups were compared in terms of donor and recipient demographics, procurement and transplantation conditions, peak laboratory values during the first post-transplant week and results at one and three years. Results are expressed as median IQR. Results: No difference other than age in donor and recipient characteristics as well as procurement conditions was noted between both groups. Median donor age of the group A was 44 (38-45) years, in group B 62 (60-64) years and 73 (71-75) in group C. Median primary warm ischemia time (WIT) were 20 (17-22), 21 (19-25) and 19 (16-23) min, respectively (NS). Median cold ischemia time (CIT) was 236 (229-294), 245 (227-290) and 210 (195-277) min, respectively (NS). Peak AST (UI/ml) was 1162 (1072-3971), 1416 (1006-2752), and 1067 (902-4037), respectively (NS). There was no primary nonfunction and one patient needed retransplantation for artery thrombosis. Biliary complications occurred similarly in both groups, without graft loss secondary to ischemic cholangiopathy. Graft and patient survivals were not different at one and three years. Conclusion: This study shows comparable results between DCD liver transplants from younger and older donors. Therefore donor age >55 years should not be a contraindication to DCD liver transplantation if other donor risk factors (such as WIT, CIT) are minimized. [less ▲]

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See detailThe instability strip of ZZ Ceti white dwarfs and its extension to the extremely low mass pulsators
Van Grootel, Valérie ULg; Fontaine, Gilles; Brassard, Pierre et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection ... [more ▼]

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection in these stars. We report here a detailed stability survey over the whole ZZ Ceti regime, including the very low masses where three pulsators have recently been found. We computed to this aim 29 evolutionary sequences of DA models with various masses and chemical layering. These models are characterized by the so-called ML2/α=1.0 convective efficiency and take into account the important feedback effect of convection on the atmospheric structure. We pulsated these models with the Liege nonadiabatic pulsation code MAD, which is the only one to conveniently incorporate a full time-dependent convection treatment and, thus, provides the best available description of the blue edge of the instability strip. On the other hand, given the failure of all nonadiabatic codes to account properly for the red edge of the strip, including MAD, we tested the idea that the red edge is due to energy leakage through the atmosphere. Using this approach, we found that our theoretical ZZ Ceti instability strip accounts remarkably well for the boundaries of the empirical strip. [less ▲]

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See detailForward Physics of Hadronic Colliders
Ivanov, Igor ULg

in Physics of Particles and Nuclei Letters (2013, December), 10(7), 739750

These lectures were given at the Baikal Summer School on Physics of Elementary Particles and Astrophysics in July 2012. They can be viewed as a concise introduction to hadronic diffraction, to the physics ... [more ▼]

These lectures were given at the Baikal Summer School on Physics of Elementary Particles and Astrophysics in July 2012. They can be viewed as a concise introduction to hadronic diffraction, to the physics of the Pomeron and related topics. [less ▲]

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See detailg-Mode Oscillations in Hot B Subdwarf Stars
Charpinet, Stéphane; Van Grootel, Valérie ULg; Fontaine, Gilles et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact ... [more ▼]

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact helium core burning stars can develop low amplitude oscillations with periods in the range ∼ 1 − 4 hours that correspond to low degree, mid to high order g-modes. These modes have the property to penetrate deep inside the star, down to the boundary of the central convective core. They are consequently particularly interesting as asteroseismic probes. Here we briefly review how the g-modes behave in sdB stars, focusing in particular on the seismic signatures coming from the core itself. We also briefly summarize the first seismic results obtained from space data in pioneering efforts to exploit the potential of long period sdB pulsators as deep probes of the core structure. [less ▲]

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See detailDONATION AFTER CIRCULATORY DEATH INCREASES THE CADAVERIC DONOR POOL
Le Dinh, H.; DE ROOVER, Arnaud ULg; SQUIFFLET, Jean-Paul ULg et al

in Transplant International (2013, December), 26(S2), 54-101

Background: There is a controversy on the possibility to increase the organ donor pool by donation-after-circulatory-death (DCD) and the possible decrease in donation-after-brain-death (DBD) by DCD ... [more ▼]

Background: There is a controversy on the possibility to increase the organ donor pool by donation-after-circulatory-death (DCD) and the possible decrease in donation-after-brain-death (DBD) by DCD programs. Our aim is to report the DCD experience at the University Hospital of Liege, Belgium, from 2002 through 2012, in a donor region of about 1 million inhabitants. Methods: The prospective organ donor and recipient databases were retrospectively reviewed. Results: 94 and 331 procurements were performed from controlled DCD and DBD donors in the time period, respectively. DCD donors contributed to 22.1% of the deceased donor (DD) organ procurement activity from Jan 2002 to Dec 2012, and up to one-third annually since 2009. DCD liver and kidneys contributed 23.7% and 24.2% of the DD liver and kidney transplantation activity, respectively. There was no decrease of the DBD procurement in the study period. In 2012, overall 54 DD were procured in the Liege region, reaching a high procurement activity.Conclusions: Controlled DCD donors are a valuable source of transplantable liver and kidney grafts, and in our experience do not adversely affect DBD organ procurement activity. [less ▲]

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See detailA spectral operator-theoretic framework for global stability
Mauroy, Alexandre ULg; Mezic, Igor

in Proceedings of the IEEE Conference on Decision and Control (2013, December)

The global description of a nonlinear system through the linear Koopman operator leads to an efficient approach to global stability analysis. In the context of stability analysis, not much attention has ... [more ▼]

The global description of a nonlinear system through the linear Koopman operator leads to an efficient approach to global stability analysis. In the context of stability analysis, not much attention has been paid to the use of spectral properties of the operator. This paper provides new results on the relationship between the global stability properties of the system and the spectral properties of the Koopman operator. In particular, the results show that specific eigenfunctions capture the system stability and can be used to recover known notions of classical stability theory (e.g. Lyapunov functions, contracting metrics). Finally, a numerical method is proposed for the global stability analysis of a fixed point and is illustrated with several examples. [less ▲]

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See detailStimuli-responsive magnetic nanohybrids for triggered drug release and potential tumor treatment via hyperthermia
Liu, Ji ULg; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Controlled Release (2013, November 28), 172(1), 39

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See detailLarge Nc baryons and Regge trajectories
Matagne, Nicolas; Stancu, Floarea ULg

in Bled Workshops in Physics (2013, November), 14(1), 37-42

The mixed symmetric positive and negative parity baryons are described in a similar way in the $1/N_c$ expansion method of QCD by using a procedure where the permutation symmetry is incorporated exactly ... [more ▼]

The mixed symmetric positive and negative parity baryons are described in a similar way in the $1/N_c$ expansion method of QCD by using a procedure where the permutation symmetry is incorporated exactly. This allows to express the mass formula in terms of a small number of linearly independent operators. We show that the leading term follows a different Regge trajectory from that found for symmetric states, when plotted as a function of the band number $N$. [less ▲]

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See detailVitamin D coverage among adults in Wallonia (Belgium): findings from the NESCaV study
Hoge, Axelle ULg; Donneau, Anne-Françoise ULg; Streel, Sylvie ULg et al

in European Journal of Public Health (2013, November), 23

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See detailPrevalence of cardiovascular risk factors in Wallonia (Belgium): results from the NESCaV study
Streel, Sylvie ULg; Donneau, Anne-Françoise ULg; Hoge, Axelle ULg et al

in European Journal of Public Health (2013, November)

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See detailL’admissibilité de la preuve en droit civil et en droit pénal
Kefer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2013, November), (2), 195-229

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See detailDNA fingerprinting using Diversilab system for genotyping characterization of Microsporum audouinii and Trichophyton violaceum
SACHELI, Rosalie ULg; DIMO, Lauryl; GRAIDE, Hélène ULg et al

in Mycoses (2013, October 01), 56(Supplement S3), 99

Objectives: To investigate the epidemiological determinants responsible for the high number of anthropophilic dermatophytes received by the National Reference Center for Mycosis of Liege (NRCL) during the ... [more ▼]

Objectives: To investigate the epidemiological determinants responsible for the high number of anthropophilic dermatophytes received by the National Reference Center for Mycosis of Liege (NRCL) during the year 2012. To perform a genotypic characterization by the Diversilab® system focusing on the two main isolated species, Microsporum audouinii and Trichophyton violaceum. To present a preliminary study preceding the national survey launched in 2013. Methods: A total of 51 strains of M. audouinii (50 clinical + 1 reference (ref.) strains) and 15 strains of T. violaceum (14 clinical + 1 ref. strain) originating from different locations through Belgium were included in the study. The fungal strains were first cultivated on Malt agar, then sub-cultured in Sabouraud liquid medium (Fluka). The grown mycelium was processed for DNA extraction following recommendations of the manufacturer (Ultra Clean® DNA Microbial isolation kit, MoBio laboratories). Genotypic analysis was performed using the DiversiLab® system (BioMérieux) for DNA fingerprinting and analysis. Results: Regarding M. audouinii, four different genotypic groups of strains were separated. Group 1 includes 11 strains and is only found in the Liège surroundings. Group 2 includes only one strain with little differences compared to group 1 and collected from the Liège area. These two groups may be related to each other. Group 3 contains 36 strains and the reference strain. This genotype is distributed in different Belgium locations. The last group, group 4, contains only 3 isolates sharing low similarities in comparison with the 3 other groups. Concerning T. violaceum, 6 different genotypic groups with a mixed geographical distribution were determined. Group 1 includes 8 clinical isolates and the ref. strain. The other five isolates are all different and seem not to be related to each other. Conclusion: The automated typing DiversiLab® system proved to be an easy and efficient method to investigate the molecular epidemiology of dermatophytes infections. Preliminary results of the study show that, through Belgium, several groups of isolates co-exist for M. audouinii and T. violaceum providing evidence of genetic heterogeneity. This variation can be related to acquired mutations due to environmental adaptation. Further investigations are necessary to better understand the impact of this genotypic variation. [less ▲]

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See detailHyper-volatiles in Comet C/2010 G2 (Hill)
Kawakita, Hideyo; Dello Russo, N.; Vervack, R. J. J. et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The ... [more ▼]

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The comet had been in outburst. Over the two nights of our observations, prominent emission lines of CH4 and C2H6 along with weaker emission lines of H2O, HCN, CH3OH and CO were detected. The gas production rate of CO was comparable to that of H2O. The mixing ratios of CO, HCN, CH4, C2H6, and CH3OH with respect to H2O are higher than those for normal comets by a factor of five or more. Hyper-volatile species such as CO and CH4 were enriched in the coma of comet Hill suggesting that the sublimation of these hyper-volatiles could sustain the outburst of the comet. Based on a comparison with optical observations, some fraction of water in the inner coma existed as icy grains. Those icy ice grains were likely ejected from nucleus by the sublimation of hyper-volatiles. [less ▲]

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See detailStudy of the Forbidden Oxygen Lines in Comets at Different Heliocentric and Nucleocentric Distances
Decock, Alice ULg; Rousselot, P.; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

Oxygen is an important element in the chemistry of the solar system objects given its abundance and its presence in many molecules including H2O 80% of cometary ices). The analysis of oxygen atoms in ... [more ▼]

Oxygen is an important element in the chemistry of the solar system objects given its abundance and its presence in many molecules including H2O 80% of cometary ices). The analysis of oxygen atoms in comets can provide information not only on the comets themselves but also on the solar system. These atoms have been analyzed using the 3 forbidden oxygen lines [OI] observed in emission in the optical region at 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the red lines) (Swings, 1962). Our analysis is based on a sample of 12 comets of various origins. The observing material is made of 53 high signal-to-noise spectra obtained with the high-resolution UVES spectrograph at the ESO VLT from 2002 to 2012 (Manfroid et al, 2009). After noticing that the green line is blended with one C2 line, we built synthetic spectra of C2 for each observing circumstances and we subtracted its contribution to the cometary spectra in order to ensure the decontamination of the 5577 Å line. Then, we measured the intensity of the 3 [OI] lines at different heliocentric distances. By comparing the green to red lines ratio (G/R) with the Bhardwaj & Raghuram (2012) effective excitation rates, we found that H2O is the main parent molecule when the comet is observed at 1 au. When the comet is located beyond 2.5 au from the Sun, CO2 also contributes to the production of oxygen. Studying forbidden oxygen lines could be a new way to estimate the abundances of CO2 in comets, a very difficult task from the ground (Decock et al. 2013). In order to estimate the effect of the quenching on our results, we analyzed the evolution of the G/R ratio at different nucleocentric distances. For nearby comets, we divided the extended 2D spectrum into several zones in order to analyze the oxygen lines as close as possible to the nucleus (down to ~10 km for the closest comets). Their analysis will allow us to study the link of the oxygen lines with the nucleocentric distance. We found a clear variation of the G/R ratio close to the comet nucleus that is in agreement with a contribution from CO2 as predicted by Raghuram & Bhardwaj (2013). [less ▲]

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See detailThe May 4, 2013 Stellar Occultation by Pluto and Implications for Pluto's Atmosphere
Olkin, Catherine B.; Young, L. A.; Borncamp, D. et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

On May 4 2013, Pluto passed in front of a 14 star and the shadow was well observed from multiple occultation groups. This paper presents results from the three light curves observed at Las Cumbres ... [more ▼]

On May 4 2013, Pluto passed in front of a 14 star and the shadow was well observed from multiple occultation groups. This paper presents results from the three light curves observed at Las Cumbres Observatory Global Telescope Network (LCOGT) from their Cerro Tololo site. The three LCOGT telescopes have 1.0 m apertures and used identical frame-transfer cameras. The cameras currently have a 2 second readout time therefore autonomous observations were scheduled with different exposure times to give good time resolution of the event. We will present results of this occultation and compare occultation results from 1988 to 2013 with volatile transport models. [less ▲]

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See detailA Search For 15NH2 Emission Lines In Comets
Rousselot, Philippe; Pirali, O.; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

The determination of nitrogen isotopic ratios in solar system objects is important for a good understanding of their origin. The measurements of [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio done so far in ... [more ▼]

The determination of nitrogen isotopic ratios in solar system objects is important for a good understanding of their origin. The measurements of [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio done so far in various solar system objects and molecules have revealed a great diversity (from 50 to 441), all of them, except Jupiter, being enriched in [SUB]15[/SUB]N compared to the protosolar nebula. Different explanations have been proposed to explain this enrichement. One of them suggests that these differences reflect the different interstellar N reservoirs from which N-bearing molecules are originating (Hily-Blant et al., 2013). These authors, from observations of H[SUB]13[/SUB]CN and HC[SUB]15[/SUB]N in two prestellar cores, suggest that the molecules carrying the nitrile- (-CN) functional group would be more enriched in [SUB]15[/SUB]N than the molecules carrying the amine (-NH) functional group. Comets are interesting targets to test this theory because they contain both HCN and NH[SUP]3[/SUP] molecules. So far the [SUB]14[/SUB]N/[SUB]15[/SUB]N ratio has only been measured in CN (Arpigny et al., 2003; Manfroid et al., 2009) and HCN (Bockelée-Morvan et al., 2005, 2008) in comets, leading for both species to [SUB]14[/SUB]N/[SUB]15[/SUB]N ≈ 150. Our work aimed at measuring the [SUB]14[/SUB]N/[SUB]15[/SUB]N isotopic ratio in NH[SUP]2[/SUP], which comes from NH[SUP]3[/SUP]. We have determined accurately the wavelengths of [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines with the AILES beamline spectrometer at synchrotron SOLEIL by Fourier transform spectroscopy. The analysis of this spectrum has permitted to extract the [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines wavelengths and to search for [SUB]15[/SUB]NH[SUP]2[/SUP] cometary emission lines. Thanks to a collection of spectra of 12 different comets obtained from 2002 to 2011 with the UVES spectrometer at the VLT ESO 8-m telescope (Manfroid et al., 2009), it has been possible to search for [SUB]15[/SUB]NH[SUP]2[/SUP] emission lines with a high sensitivity. We will present the results obtained from these data. Arpigny et al., Science, 301, 1522-1525, 2003 Bockelée-Morvan et al., in Comets II, ed. M. C. Festou, H. U. Keller, & H. A. Weaver (Tucson: Univ. Arizona Press), 391-423, 2005 Bockelée-Morvan et al., ApJ, 679, L49-L52, 2008 Hily-Blant et al., Icarus 223, 582-590, 2013 Manfroid et al., A&A, 503, 613-624, 2009 [less ▲]

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See detailUne infiltration de plasma riche en plaquettes (PRP) pour traiter les tendinopathies rotuliennes supérieures chroniques
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1),

Objective: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

Objective: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. Infiltration of platelet-rich plasma (PRP) could be a new therapy for such chronic tendinopathies. Materiel and methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10-point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. Results: Pain during daily activities significantly decreased with time (especially after 6 weeks and continued to a lesser extend up to 3 months). During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. Discussion: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol is efficient to improve symptoms of chronic jumper’s knee in patients non-responsive to classical conservative treatments. [less ▲]

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See detailActualités thérapeutiques dans la prise en charge des tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1), 050-003

“Conventional” treatments of tendinopathies are generally employed empirically to fight pain and inflammation but they do not modify the histological structure of the tendon. However, these treatments are ... [more ▼]

“Conventional” treatments of tendinopathies are generally employed empirically to fight pain and inflammation but they do not modify the histological structure of the tendon. However, these treatments are not completely satisfactory and the recurrence of symptoms is common. In contrast to the passive pattern of many therapies dedicated to tendon disorders, some authors have promoted an eccentric training mode. Such active eccentric training programs are aimed at thwarting an aetiopathogenic theory proposing insufficient tensile strength of the tendon exposed to external loads which could progressively damage it. Though the literature remains incomplete on tendon architecture remodelling and real histological adaptations following an adapted eccentric training, clinical results following such therapy appear promising. Due to its noninvasiveness, low complication rate and high applicability combined with good results, extracorporeal shock wave therapy has become a well known option within the therapeutic spectrum for many tendinopathies. More specifically, it has been successfully applied in chronic tendinopathy resistant to a conservative training program including eccentric exercises. Platelets release different cytokines and growth factors that could promote angiogenesis, tissue remodelling (bone, skin etc.), and wound healing. Platelet-rich plasma (PRP) is obtained by centrifuging autologous blood to have a high concentration of platelets depending on the isolation method. For this reason, different PRP preparation techniques cannot provide a consistently identical final product, but there is currently no international consensus on this issue. Despite the proven efficacy of PRP tissue regeneration in labs, there is currently little tangible clinical evidence for chronic tendon disorders. The few studies that have been performed appear unlikely to be comparable. Up to now, randomised controlled studies with appropriate placebo groups are needed to determine the real effectiveness of PRP for treating chronic tendon conditions. However, this therapeutic option remains very popular in sports, and many top athletes are using it in case of musculoskeletal conditions. What is more, it has been removed from the doping lost of the World AntiDoping Agency. Other new therapeutic options (infiltrations of polidocanol, hyaluronic acid, botulinum toxin, patches of derivatives Nitro...) for treating tendinopathies are also discussed in this review. [less ▲]

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See detailInvestigation olfactive de la mort
Focant, Jean-François ULg; Stefanuto, Pierre-Hugues ULg; Brasseur, Catherine ULg et al

in Acta Clinica Belgica (2013, October), 68-6

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See detailPratique des actes préventifs : ce qui détermine l'attitude des médecins généralistes belges
Vanmeerbeek, Marc ULg

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2013, October), 61(octobre), 309

En Belgique, l’implémentation des procédures préventives reste insuffisante dans plusieurs domaines, avec un gradient socio-économique défavorable aux moins nantis. Une implication accrue des médecins ... [more ▼]

En Belgique, l’implémentation des procédures préventives reste insuffisante dans plusieurs domaines, avec un gradient socio-économique défavorable aux moins nantis. Une implication accrue des médecins généralistes pourrait améliorer ces deux aspects, grâce à leur proximité avec les bénéficiaires potentiels. L’opinion des généralistes belges sur un investissement accru en prévention a été évaluée au moyen d’une échelle d’attitude construite au départ de verbatims provenant d’une enquête qualitative préalable. L’échelle a exploré 5 axes : vision globale de la santé, gestion collective des patients, évaluation de processus, collaboration et santé publique. Un questionnaire postal a été envoyé à 2.500 généralistes, dont 457 ont répondu valablement. L’axe gestion collective a obtenu la moyenne des scores d’attitude favorable à la prévention la plus élevée (77%), devant les axes santé globale (76%), évaluation (72%), collaboration (69%) et santé publique (63%). L’analyse factorielle a révélé deux facteurs principaux, l’organisation de la pratique (62% de la variance) et la formalisation (14% de la variance). L’organisation de la pratique (gestion des échéances, des données, pro-activité, sentiment de responsabilité envers la patientèle) était le facteur principal et était lié surtout aux associations et groupes pluridisciplinaires. La formalisation (codification précise de la pratique, assortie ou non d’une évaluation) venait ensuite et expliquait les plus fortes différences entre praticiens et entre communautés linguistiques. Les meilleurs scores étaient liés à une moindre ancienneté (<20 ans de pratique), aux associations et à la pratique urbaine. Le sexe du médecin ou le fait de travailler dans une structure préventive comme la protection maternelle et infantile étaient sans effet significatif. L’organisation de la prévention dépend des gouvernements de Flandre et de Wallonie-Bruxelles, mais des facteurs personnels et organisationnels propres aux généralistes doivent être considérés pour expliquer les résultats actuels. Une diffusion plus large et équitable des actes préventifs passe par la prise en compte de ces facteurs. [less ▲]

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See detailEvaluation de l’implantation de la vaccination contre le papillomavirus dans les pratiques des services de santé scolaire en Fédération Wallonie Bruxelles
Miermans, Marie-Christine ULg; Swennen, Béatrice; Vermeeren, Axelle

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2013, October), 61(Supplément 4), 233

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See detailGerminome intracrânien bifocal : la biopsie est-elle toujours indispensable?
KREUTZ, Julie ULg; BONNEVILLE, Jean-François ULg; Potorac, Iulia ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailElaboration de critères pour l'évaluation de "l'agir" du plan national nutrition santé en Belgique
Absil, Gaetan ULg; Schippers, Nathalie ULg; Vandoorne, Chantal ULg

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2013, October), 61(4), 304

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See detailLe carcinome parathyroïdien familial : une forme agressive d'hyperparathyroïdie primaire
Tudorescu, A; VROONEN, Laurent ULg; BETEA, Daniela ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailRéaction inflammatoire exubérante comme effet secondaire d’une infiltration de PRP
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; LEONARD, Philippe ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(Sup 1), 068

Introduction : Infiltrations of plasma rich platelets (PRP) represent a new treatment of tendinopathies. Currently, no side effects were reported in this indication. Case report: We report the case of a ... [more ▼]

Introduction : Infiltrations of plasma rich platelets (PRP) represent a new treatment of tendinopathies. Currently, no side effects were reported in this indication. Case report: We report the case of a 35-year-old type 1 diabetic patient with right upper patellar tendinopathy that had persisted for more than 6 months. The patient benefited from an intratendinous infiltration of 6 mL of PRP (8.105 platelets/mm3, almost no red or white blood cells) after a carefully disinfection but without local anesthesia. Typically, a standardized program of sub-maximal eccentric rehabilitation should be started 1 week after infiltration. However, the patient experienced local swelling with erythema, increased heating and pain, which appeared just underneath the patella, without biological inflammatory syndrome. In absence of septic general symptoms, no blood or wound culture were made. At 2 weeks post-infiltration, a greatly increased Doppler signal in a thicker tendon was observed by ultrasounds compared to that before infiltration, but there was no sign of infection demonstrated by either MRI or CT. However, the local inflammation did not decrease after a 3-week treatment of local cryotherapy, local and oral NSAID, and adjunct use of colchicine 1 mg. Thus, an insidious infection was suspected, even though there was no evidence of biological inflammatory syndrome or sign of infectious lesion on imagery examination. Antibiotic therapy (rifampicine 600 mg + minocycline 100 mg), was initiated for three months. Due to a lack of improvement via imaging and clinical examination, a 3-phase bone scintigraphy was performed. The results suggested the presence of a complex regional pain syndrome type 1. The patient benefited from classical physical therapy and concomitant pain killers. The evolution was favorable after 6 months of treatment. Discussion : Even though PRP infiltration represents a new and promising treatment for tendinopathy, more studies are needed both to verify its clinical efficacy. Moreover, implementing this innovative treatment requires caution because of potential adverse events. Thus, the balance between benefits and risks must be carefully evaluated before using this treatment, especially in patients with type 1 diabetes. [less ▲]

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See detailCorrélations significatives de l'aspect en IRM haute résolution des adénomes hypophysairesà GH avant traitement
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Schillo, F et al

in Annales d'Endocrinologie (2013, October), 74

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See detailLe PPNAD, une cause rare de syndrome de Cushing
PETIGNOT, Sandrine ULg; VROONEN, Laurent ULg; HAMOIR, Etienne ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailStrength improvement after 3months of resistance training among Parkinson's disease patients
Demonceau, Marie ULg; rodriguez de la cruz, carlos; NAVEAU, Florence ULg et al

in Annals of Physical and Rehabilitation Medicine (2013, October), 56(s1), 196

Objectives.– To assess the feasibility and the effects of a strengthening program for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn and Yahr stage [1] < III of PD were ... [more ▼]

Objectives.– To assess the feasibility and the effects of a strengthening program for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn and Yahr stage [1] < III of PD were allocated to either 24 sessions of strength training (ST group; n = 8) or to a control group (C group; n = 6) for 3 months. Concentric knee muscle strength and a maximal cycling incremental test were performed at baseline and after training. Training consisted of progressive resistive exercises on leg press, leg extension, leg curl, between 50 and 80% of 1RM and was completed by non-instrumented exercises for trunk and upper limbs muscles. Anxiety, depression and quality of life were assessed using questionnaires. An Anova for repeated measures was used for statistical analysis. Results.– Six patients of the ST group (75%) fully completed the program. There were significant “group by time” effects for all knee muscles strength measures of less involved side (P < 0.05). A significant “group by time” effect was also found for knee flexors of the most involved side, but only at angular speed of 180°/s (P = 0.03). Patients of ST group also increased maximal aerobic power (+13%) whereas patients of C group decreased their performances (–9%; “group by time” effect, P = 0.04). No changes in anxiety, depression or quality of life could be highlighted. Conclusions.– The increase of some strength measures in ST group showed that progressive strength training counteracts strength decrease among people with Parkinson's disease. Strengthening also had a positive effect on maximal aerobic power. [less ▲]

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See detailUne néoplasie endocrinienne multiple particulière
Boccar, S; VROONEN, Laurent ULg; HAMOIR, Etienne ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailHypothyroïdie infraclinique non auto-immune et statut iodé : étude prospective d'intervention
VALDES SOCIN, Hernan Gonzalo ULg; Tudorescu, A; Lutteri, L et al

in Annales d'Endocrinologie (2013, October), 74

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See detailFIPA : étude clinique et génétique à l'Hôpital "King Edward Memorial", Bombay (Mumbai) Inde
Bothra, N; Daly, Adrian ULg; CASTERMANS, Emilie ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailLe gigantisme : Les résultats d'une étude clinique et génétique internationale
Rostomyan, Liliya ULg; Daly, Adrian ULg; Lila, A et al

in Annales d'Endocrinologie (2013, October), 74

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See detailCoexistence entre adénom hypophysaire et phéochromocytome - présentation de cas
Rostomyan, Liliya ULg; Potorac, Iulia ULg; Filipponi, S et al

in Annales d'Endocrinologie (2013, October), 74

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See detailReceptor expression in craniopharyngiomas causing tumor growth in pregnancy : case report and review of the literature
Tome, M; VROONEN, Laurent ULg; THIRY, Albert ULg et al

in Annales d'Endocrinologie (2013, October), 74

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See detailTRAPPIST (TRAnsiting Planets and PlanetesImals Small Telescope)
Jehin, Emmanuel ULg; Gillon, Michaël ULg; Opitom, Cyrielle ULg et al

in EPSC Abstract 2013 (2013, September 13), 8

TRAPPIST is a 60-cm robotic telescope that has been installed in June 2010 at the ESO La Silla Observatory [1]. Operated from Liège (Belgium) it is devoted to the detection and characterisation of ... [more ▼]

TRAPPIST is a 60-cm robotic telescope that has been installed in June 2010 at the ESO La Silla Observatory [1]. Operated from Liège (Belgium) it is devoted to the detection and characterisation of exoplanets and to the study of comets and other small bodies in the Solar System. We describe here the hardware and the goals of the project and give an overview of the comet production rates monitoring after three years of operations. [less ▲]

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See detailCould bonobos, Pan paniscus, influence forest re(colonization) in a forest-savana mosaic?
Trolliet, Franck ULg; Serckx, Adeline ULg; Huynen, Marie-Claude ULg et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, September 12)

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See detailTRAPPIST monitoring of comet C/2012 F6 (Lemmon)
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in EPSC Abstract 2013 (2013, September 12), 8

Comet C/2012 F6 is a long-period comet that reached perihelion on March 23, 2012. The unexpected brightness of this comet since December 2012 allowed us to obtain narrowband photometry and to study its ... [more ▼]

Comet C/2012 F6 is a long-period comet that reached perihelion on March 23, 2012. The unexpected brightness of this comet since December 2012 allowed us to obtain narrowband photometry and to study its chemical composition as well as its rotation. [less ▲]

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See detailStudy of the forbidden oxygen lines in comets at different heliocentric and nucleocentric distances
Decock, Alice ULg; Jehin, Emmanuel ULg; Rousselot, Philippe et al

in EPSC Abstract 2013 (2013, September 12), 8

Oxygen is an important element in the chemistry of the Solar System objects given its abundance and its presence in many molecules including H2O, which constitutes 80% of cometary ices. The analysis of ... [more ▼]

Oxygen is an important element in the chemistry of the Solar System objects given its abundance and its presence in many molecules including H2O, which constitutes 80% of cometary ices. The analysis of oxygen atoms in comets can provide information not only on the comets themselves but also on our Solar System. These atoms have been analyzed using the three forbidden oxygen lines [OI] observed in emission in the optical region at 5577 Å (the green line), 6300 Å and 6364 Å (the red lines) [1]. These lines are difficult to analyze because their detection requires high spectral and spatial resolutions. The oxygen analysis is interesting because it allows the determination of its parent molecules. [less ▲]

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See detail"Product-oriented engineering" applied to the development of porous scaffolds for tissue engineering.
de Bien, Charlotte ULg; Ounally, Thameur ULg; Collard, Valérie ULg et al

in Procedia Engineering (2013, September 02)

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D ... [more ▼]

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D microstructure was characterized by X-ray microtomography and related to the operating conditions used. Two types of scaffold end-use properties were characterized in relation to their microstructure: the mechanical and the transport properties. Scaffold young's modulus was computed from data measured on tension-compression devices. To evaluate the permeability, Darcy’s experiments were carried out. The obtained results allowed highlighting the quantitative relationships existing between elaboration conditions, microstructure and end use properties of the fabricated PLA scaffolds. [less ▲]

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See detailEvaluation of Everolimus (EVE) in HER2+ advanced breast cancer (BC) with activated PI3K/mTOR pathway : exploratory biomarker observations from the BOLERO-3 trial
JERUSALEM, Guy ULg; ANDRE, Fabrice; CHEN, David et al

in European Journal of Cancer (2013, September), 49(Supplement 3), 8

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See detailIntérêt des ondes de choc dans le traitement des fasciites plantaires
Fromm, Aurélien; Vanderthommen, Marc ULg; LAURENT, Jean-Marie ULg et al

in European Journal of Sports Medicine (2013, September), 1(Supplement 1), 276-277

Introduction : Over the past ten years, radial shock wave therapy usage has grown tremendously. Prescribed for chronic tendinopathy, its real benefit has yet to be demonstrated. Objective : Demonstrate ... [more ▼]

Introduction : Over the past ten years, radial shock wave therapy usage has grown tremendously. Prescribed for chronic tendinopathy, its real benefit has yet to be demonstrated. Objective : Demonstrate radial shock wave therapy benefits in plantar fasciitis treatment. Materials and methods : Our experimentation is a study over twelve weeks divided in 2 periods: the control phase (week 0 to week 6) and treatment phase (week 6 to week 11). It includes 3 evaluations (T1, T2 and T3) respectively at 0, 6 and 11 weeks. A standard evaluation consists of one VAS pain, an algo-functional backwash survey about the ankle (modified FFI), algometer test and dynamic analysis of the foot on strength platform. The radial shock wave therapy has been performed thanks to Swiss DolorClast machine (Electro Medical Systems) Results : Statistical analysis show radial shock wave therapy induces a highly significant improvement (p<0,0001) on EVA results (50%), ankle algo-functional backwash (62.6%) and pain sensitivity threshold (49.6%). Therefore, a significant correlation can be observed during T2- T3 period between pain sensitivity threshold improvement and patients age (p=0,012). The statistical results show a time increase trend for foot-ground contact over time. It is not significant though. Conclusion : The use of radial shock wave therapy in plantar fasciitis treatment helps decrease pain and improve step. However, additional studies performed on bigger samples have to be completed to confirm these results. [less ▲]

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See detailIMMUNOHISTOCHEMICAL ANALYSIS OF TRANSFORMING GROWTH FACTOR BETA 1 AND ITS SIGNALLING PATHWAYS IN CANINE IDIOPATHIC PULMONARY FIBROSIS
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailCaractéristiques cliniques des sujets répondeurs à la vibrotonie corporelle totale
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Maquet, Didier ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 118-119

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See detailEffect of the lengthening of the protocol on the reliability of knee muscle fatigue indicators
Bosquet, L.; Maquet, Didier ULg; Forthomme, Bénédicte ULg et al

in European Journal of Sports Medicine (2013, September), 1(1), 150

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See detailImpacts of WLG on the regeneration of logged forests: preliminary insights in a Gabonese logging concession
Haurez, Barbara ULg; Petre, Charles-Albert ULg; Doucet, Jean-Louis ULg

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, September), 84(3-5), 284-285

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See detailA case of Longitudinal Vaginal Septum in a mare
Parrilla Hernandez, Sonia ULg; Ponthier, Jérôme ULg; Deleuze, Stefan ULg

in Reproduction in Domestic Animals (2013, September), 48(suppl1), 112-113

LVS occurs when there is failure in the fusion of müllerian ducts or in the regression of the vaginal septum. Primary or secondary cause of infertility, increases the risk of dystocia or alter sport ... [more ▼]

LVS occurs when there is failure in the fusion of müllerian ducts or in the regression of the vaginal septum. Primary or secondary cause of infertility, increases the risk of dystocia or alter sport performance. It is most likely under-diagnosed as it is often asymptomatic and an incidental finding. [less ▲]

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See detailPyovagina caused by pyometra and a persistent hymen in a 9-year-old bitch
Van Den Berghe, Femke ULg; Ponthier, Jérôme ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (2013, September), 48(suppl1), 114

Pyovagina with a persistent hymen is very uncommon in a 9-year-old intact bitch. Blood discharge during prooestrus phases of previous cycles and the recent purulent vulvar discharge indicate an -at least ... [more ▼]

Pyovagina with a persistent hymen is very uncommon in a 9-year-old intact bitch. Blood discharge during prooestrus phases of previous cycles and the recent purulent vulvar discharge indicate an -at least partially- perforated hymen. For an unknown cause the hymen must have re-sealed after uterine contamination explaining a pyovagina that was bulging in the perineal area [less ▲]

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See detailGP’s engagement in detecting and managing abuse of alcohol, illegal drugs, hypnotics and tranquilizers in the Belgian adult population
Ketterer, Frédéric ULg; Lambrechts, Marie-Claire; Symons, Linda et al

in European Journal of General Practice (2013, September), 19(3), 162-184

Background General practitioners (GPs) Occupational physicians (OPs) can play an important role in detecting and managing substance abuse in the working population. The UP TO DATE project aims at ... [more ▼]

Background General practitioners (GPs) Occupational physicians (OPs) can play an important role in detecting and managing substance abuse in the working population. The UP TO DATE project aims at identifying the difficulties these professionals encounter in this area, and to explore ways of collaboration in providing appropriate care. Research question What are the experiences, attitudes and decision making of GPs and OPs regarding to alcohol, illegal drugs, hypnotics and tranquilizers abuse from a physician’s perspective? Method In this qualitative study, with a phenomenological perspective, 20 GPs and 16 OPs, experienced with substance abuse in daily practice, got a face to face in-depth interview. (October until December 2012). Along with the data collection process the analysis started with a constant comparison between the data and the chosen integrated model of change (De Vries), using coding techniques of grounded theory. Results GPs meet important barriers to detect misuse of all substances. To address this issue and the patient’s motivation for change, the doctor-patient relationship is crucial. The risk to disturb the relationship, and loose the patient’s trust, is a major concern. An attitude of patient-centeredness, collaboration and empowerment of the patient is needed to make any progress, to get results and to overcome as a GP the burden of those demanding encounters. Self-care is an important concern. Collaboration with specialised health providers confronted GPs with various problems: not enough services, long waiting lists, unclear methods and criteria. GPs lack an insight in the OP’s role, and experience problems to contact them. Whether the OP is a trustful health advocate for their patient is a major concern. Some OPs are perceived too linked to the employer, raising legitimate concerns about professional confidentiality. Conclusion These are preliminary results. At the conference, a comprehensive overview on the qualitative analysis will be given. [less ▲]

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See detailImmunohistochemical transforming growth factor Beta1 and its activation, storage and signalling pathways in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailInfluence of game playing on the muscular profile of shoulder rotators of handball players
Ucay, O.; Gasq, D.; Forthomme, Bénédicte ULg et al

in European Journal of Sports Medicine (2013, September), 1(1), 105

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See detailIs 5-Hydroxytryptamine (serotonin) involved in the pathogenesis of idiopathic pulmonary fibrosis in dogs ?
Krafft, Emilie ULg; Roels, Elodie ULg; Laurila et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailImportance du déficit en vitamine D chez les femmes françaises ostéoporotiques et ostéopéniques âgées de plus de 80 ans
Bruyère, Olivier ULg; Slomian, Justine ULg; Beaudart, Charlotte ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 75

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See detailRéaction inflammatoire exubérante suite à une infiltration de PRP
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; LEONARD, Philippe ULg et al

in European Journal of Sports Medicine (2013, September), 1(Supplement 1), 278-279

Background: PRP, obtained from centrifuged autologous blood, contains a large quantity of growth factors, which may enhance the tissue healing processes. Local infiltration of PRP represents a relatively ... [more ▼]

Background: PRP, obtained from centrifuged autologous blood, contains a large quantity of growth factors, which may enhance the tissue healing processes. Local infiltration of PRP represents a relatively new treatment for tendinopathies. To date, no side effects have been reported after infiltration of PRP to treat tendinopathy. Case report: A 35-year-old patient had a right upper patellar tendinopathy which was resistant to all conservative treatments for more than 6 months. The patient was a type 1 diabetic (well controlled). He had an intratendinous infiltration of 6 mL of PRP (8.105 platelets/mm3, almost no red or white blood cells) after disinfection but without local anaesthetic. Immediately following the infiltration, local cryotherapy was performed for 15 minutes. NSAIDs were avoided, but class-1 or -2 pain-killers were authorised if necessary. A standardised sub-maximal eccentric rehabilitation should have been started 1 week after. However, the patient experienced local swelling with erythema, increased heating and pain which appeared just underneath the patella, but without biological inflammatory syndrome. A great Doppler signal in a thicker patellar tendon was observed by US, but there was no sign of local infectious disease demonstrated by either CT or MRI. However, the local inflammation did not decrease after a progressive 3-week treatment of local cryotherapy, local and oral NSAIDs and colchicine 1 mg. Thus, an insidious infection was suspected, even though there was neither evidence of biological inflammatory syndrome nor sign of infectious lesion on imagery examination. An antibiotic therapy (rifampicine 600 mg + minocycline 100 mg) was initiated for 3 months. Finally, a 3-phase bone scintigraphy suggested the presence of a complex regional pain syndrome type 1 treated by a classical physical therapy and concomitant class-2 pain killers. The evolution was favourable after 6 months of symptomatic treatment, and the pain decreased to a level similar to that before the infiltration of PRP. Discussion/Conclusions: This case report draws attention to potential side effects that are linked to this new therapy by infiltration of platelet rich plasma in case of tendinopathy, in particular when used in patients with type 1 diabetes. Thus, the balance between benefits and risks must be carefully evaluated before using this treatment in patients with type 1 diabetes. [less ▲]

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See detailLes effets d'une supplémentation en vitamine D sur la force musculaire : une méta-analyse d'essais randomisés contrôlés
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Rabenda, Véronique ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 38

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See detailHazard factors of ACL rupture: Neuromuscular factors
Kaux, Jean-François ULg; Delvaux, François ULg; MASSART, Nicolas ULg et al

in European Journal of Sports Medicine (2013, September), 1(supplement 1), 50-51

Injuries to the anterior cruciate ligament (ACL) of the knee are disabling, often associated with other intra-articular damages and increase the risk of early onset of osteoarthritis. It is very probable ... [more ▼]

Injuries to the anterior cruciate ligament (ACL) of the knee are disabling, often associated with other intra-articular damages and increase the risk of early onset of osteoarthritis. It is very probable that multiple risk factors act in combination to influence injury risk. It is important to have a comprehensive understanding of these ACL risk factors, whose neuromuscular factors, even if investigations on neuromuscular factors reported to date do not provide a complete understanding of ACL injury risk. According to several recent studies, the neuromuscular control of joint biomechanics during a specific activity seems to represent a predicting factor of an ACL injury, by quantifying the intersegmental forces and moments generated about the tibio-femoral joint. Laboratory studies have shown that landing from a jump performs cutting and pivoting maneuvers with less knee and hip flexion, increases knee valgus and internal rotation of the hip coupled, with increased external rotation of the tibia and quadriceps muscle activation (especially in women). It has been hypothesized that these movement patterns increase the strain in the ACL during activity and that the large difference in knee injury incidence rates between males and females (1/4.5) may be attributed to neuromuscular differences and resultant mechanics. Although studies have shown that the position of the knee and the magnitude and sequence of muscle contraction can increase ACL strain values, it is hard to exactly correlate these movements to what occurs during activity and sport and at the time of ACL injury. Recently, a simpler assessment tool has been validated and is able to be administered in a clinic-based testing environment Consequently, the screening for ACL injury risk could be performed on a more widespread population. Athletes who went on to a primary ACL injury also demonstrated significant side to side differences in lower extremity biomechanics as well as reduced relative lower extremity flexor activation relative to an uninjured control population during the vertical drop jump. Similar mechanisms of injury risk have been identified in athletes medically cleared to return to sport after ACL reconstruction. These seminal findings indicate that these abnormal and asymmetrical biomechanical and neuromuscular control profiles are likely both residual to, and exacerbated by, the initial injury. A study revealed that a fatigue-induced protocol altered the latency as well as the magnitude of reflex responses of the hamstring muscles and the tibial translation only in women. The authors of various studies have suggested that the hamstring muscles play an important role in maintaining knee stability and that they protect the ACL during movements of the tibia relative to the femur. Therefore, decreased reflex responses of the hamstring muscles and in turn an increased the tibial translation might contribute to the pathomechanics of the ACL injuries. It is therefore conceivable that the fatigue-induced decrease of the hamstring neuromuscular function may increase the tibial translation and probably contributes to the higher incidence of ACL injuries, especially in women. A preventive approach to decrease ACL injuries could integrate muscle imbalances as a risk factor. If it has been scientifically validated than the muscle strength profile determined by an isokinetic testing offers a predictive value on the hamstring lesion occurrence, similar studies have not permitted such a conclusion about ACL injury. The isokinetic assessments after ACL reconstruction have allowed us to observe, on the healthy contralateral knee, a higher frequency of reduced hamstring/quadriceps ratios. A possible pre-existing weakness in the hamstring and the occurrence of an ACL injury is therefore possible but only a difficult prospective approach due to the multifactorial nature of ligament injuries could clarify that point. In conclusion, a functional analysis of the landing of a jump and an isokinetic muscle strength assessment have been suggested to represent predictive elements of an ACL rupture, but further studies are needed to have a stronger evidence of their predictive qualities of injury. [less ▲]

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See detailHypercalcémie réfractaire et sécrétion ectopique de calcitonine dans un cancer neuroendocrine du pancréas : Effets hypocalcémiants du Cinacalcet
VALDES SOCIN, Hernan Gonzalo ULg; LOLY, Jean-Philippe ULg; BETEA, Daniela ULg et al

in Annales d'Endocrinologie (2013, September), 74(4), 235-462

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

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See detailPhysiological interpretation of the slope during an isokinetic fatigue test of the knee
Bosquet, L.; Gouadec, K.; Berryman, N. et al

in European Journal of Sports Medicine (2013, September), 1(1), 151

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