References of "Paper published in a journal"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 101 to 200 of 4491     1 2 3 4 5 6 7     Creatinine- or cystatin C-based equations to estimate glomerular filtration rate in the general population: impact on the epidemiology of chronic kidney diseaseDELANAYE, Pierre ; Cavalier, Etienne ; Moranne, O et alin Nephrology Dialysis Transplantation (2013, May), 28(S1), Detailed reference viewed: 18 (15 ULg) Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.Sainvitu, Pauline ; Nasir, Mehmet Nail ; Nott, Katherine et alin World Academy of Science, Engineering and Technology (2013, May), 77Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic ... [more ▼]Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed. [less ▲]Detailed reference viewed: 10 (1 ULg) Is ultra-short cold ischemia the key to ischemic cholangiopathy avoidance in DCD-LT?DETRY, Olivier ; DE ROOVER, Arnaud ; Cheham, S et alin Acta Chirurgica Belgica (2013, May), Supplement 113(3), 6729Detailed reference viewed: 34 (10 ULg) Interleukin-6 as a marker of inflammatory related post-operative myocardial dysfunctionvon der Stück, H.; SCHUMACHER, Katharina ; Buding, B. et alin Cardiology in the Young (2013, May), 23(Supplement 1), 136-137Detailed reference viewed: 4 (2 ULg) Comparison of the Heart-type fatty acid-binding protein (H-FABP) with the high sensitive cardiac troponin T in healthy runnersLE GOFF, Caroline ; Kaux, Jean-François ; BREVERS, Eric et alin Biochimica Clinica (2013, May), 37(SS), 544Background: Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. It is an early marker ... [more ▼]Background: Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. It is an early marker for acute coronary syndrome. Troponin T (TnT) is a component of the contractile apparatus of the striated musculature. Cardiac TnT is a cardio-specific, highly sensitive marker for myocardial damage. The aim of our study was to compare the results obtained with the H-FABP and the highly sensitive cardiac troponins (hsTnT) and to test their cardiospecificity in healthy runners. Methods: Twenty three runners (marathon) were enrolled. We drowned samples at three times: just before (T0), just after (T1), and three hours after the end of the race (T3). H-FABP was determined with a Randox immunoturbidimetric assay and hs-TnT with a Roche electrochemiluminescence immunoassay, both on Cobas 6000. A linear regression was calculated to observe if there is any correlation between the two biomarkers. Values above the 95th percentile for H-FABP (2.5ng/mL) and the 99th percentile for hsTnT (14ng/L) were considered as positive. Results: At T0, none of the subjects were positive for hsTnT but 35% were positive for H-FABP; at T1, 83% for hsTnT and 100% for H-FABP; at T3, 83% for hsTnT and 96% for H-FABP. At T0, the regression equation was H-FABP T0 = 3.9454 – 0.1001 x hsTnT T0; at T1: H-FABP T1 = 51.838 – 1.7026 x hsTnT T1; at T3: H-FABP T3 = 47.977 – 1.6193 x hsTnT T3. No correlation was observed between the two biomarkers at the different time. Conclusions: We observed a significant increase of H-FABP and hsTnT in runners. These markers are independent to each other. These values could biologically correspond to a heart ischemia. However, we suggested that exercise-induced cardiac hsTnT and H-FABP release is not a marker of exercise-induced pathology but likely a physiologic response to effort or an exercise-induced cardiac remodelling. [less ▲]Detailed reference viewed: 21 (0 ULg) Comparison between Perkin-Elmer and Chromsytem Vitamin D kit on TQ 5500 from AB SCIEXLE GOFF, Caroline ; PEETERS, Stéphanie ; CRINE, Yannick et alin Biochimica Clinica (2013, May), 37(SS), 471Background: Twenty-five hydroxy-vitamin D (25(OH) D) determination is now routinely prescribed in the Laboratory. Recently, different new methods have been available for this determination. Among them ... [more ▼]Background: Twenty-five hydroxy-vitamin D (25(OH) D) determination is now routinely prescribed in the Laboratory. Recently, different new methods have been available for this determination. Among them, LCMS/MS methods have emerged in some laboratories. However these methods are generally “home-brewed” and an important variability between them can be seen on different external quality controls, mainly due to a lack of standardization. Recently, Perkin-Elmer (PE) (Turku, Finland) and Chromsystem (CS) (Grafelfing, Germany) launched a standardised method for 25(OH )D determination on LCMS/MS. The aim of our study was to compare these methods on the AB SCIEX TQ5500 (Framingham, Massachusetts, USA) LCMS/MS to measure 25(OH) D3. Methods All the samples were treated according to our preanalyitical procedure: after sampling, they were spun at +4°c at 3500G, aliquoted and kept frozen at -20°c until determination. A method comparison was assessed with CS and PE for the measurement of the 25(OH)D3. We selected 110 remnant samples with 25(OH)D3 levels ranging from 1.6 to 136.7 ng/ml with the PE method to cover the range of usually values Slope and intercept were calculated using Passing and Bablock linear regression and we compared the methods with the Bland and Altman plots. Results For CS, the method is linear up to 250 µg/L, the LOQ is 3.6 µg/L, the intra-assay CV is < 5% and the inter-assay is < 7%. For PE, the method is linear up to 314 µg/L, the LOQ is 3.4 µg/L, the intra-assay CV is < 7.8% and the inter-assay is < 8.5%. On the whole range of measure (n=110), the regression equation is PE = 0.8521+0.9226 (CS) (95%CI of the intercept: (-0.0048;1.37) and 95% CI of the slope (0.89;0.95). The Bland and Altman plot does not show any bias between the two methods (mean difference CS-PE= -2.5 ng/ml) and the standard deviation of the mean is 3,98 ng/ml Conclusion: The performances of these methods are comparable on our new TQ 5500 from AB SCIEX. For now, there is no consensus on a “reference” method for vitamin D quantification. We notice only that the values obtained by CS are systematically a little bit lower than PE’s values, especially for results below 20 ng/ml. However, we have no clear explanation for such behaviour. [less ▲]Detailed reference viewed: 69 (5 ULg) Race Cycling: biological evolutionLE GOFF, Caroline ; Kaux, Jean-François ; MELON, Pierre et alin Biochimica Clinica (2013, May), 37(SS), 544Background: The metabolic and cardiac impact of a cycling effort on blood biology is not very well described in the literature. We aimed to measure the concentration of different biomarkers (cardiac and ... [more ▼]Background: The metabolic and cardiac impact of a cycling effort on blood biology is not very well described in the literature. We aimed to measure the concentration of different biomarkers (cardiac and metabolic) released during an international cycling race. Methods: Venous blood samples of 15 young men (25.1 ± 6.4 y.o.) were collected just before (T1), just after (T2), 3 hours (T3) after an international cycling race of 179.6 kilometers in Belgium for the determination of cardiac and metabolic biomarkers: red blood cell (RBC), haemoglobin (HgB), creatinin (Cr), highly sensitive troponin T (hsTnT), myoglobin (MYO) and NT-proBNP. All automated assays were performed according to the manufacter’s specifications. For the statistical analysis, an Anova calculated with the Statistica Software version 9.1 was used. Results: RBC and HgB levels varied significantly between T0 and T3 (respectively p=0.0026, and p=0.002). Cr concentration also varied significantly between all times (T0-T1:p<0.0001, T1-T3:p=0.0326 and T0-T3 p=0.0001). These changes might be related to renal flow depletion during exercice. MYO increased significantly between T0 and T1 (p<0.0001), but quickly decreased between T1 and T3, however the T3 level stay higher than T0 (p=0.014). The stress delivered from the physical activity performed during the race induced a significant variation of hsTnT which increased significantly between T0 and T1 (p<0.0001) and stayed higher 3 hours after the end of the exercise (T0-T3: p<0.0001) .The intense exercise delivery by the race induced a significant variation of NT-proBNP, that followed the same kinetic of hsTnT but in smaller proportion. We noticed variations statistically significant between T0 and T1 and between T0 and T3 for NT-proBNP. These increases of cardiac biomarkers were significant but reasonable and could not allow us to talk about cellular necrosis or irreversible injury. Conclusion: Our results show that stress generated by a cycling race could be the cause for the different metabolic variations observed. Troponin T stays without a doubt the most specific marker for stress related to myocardial tissue. Its increase can then be considered as being of interest. [less ▲]Detailed reference viewed: 17 (0 ULg) Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.Sainvitu, Pauline ; Nasir, Mehmet Nail ; Nott, Katherine et alin World Academy of Science, Engineering and Technology (2013, May), 77Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic ... [more ▼]Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed. [less ▲]Detailed reference viewed: 5 (5 ULg) Holotranscobalamin as an earlier indicator of vitamin B12 deficiency in thyrogastric syndromeVRANKEN, Laura ; CAVALIER, Etienne ; VALDES SOCIN, Hernan Gonzalo in Biochimica Clinica (2013, May), 37(SS), 324Detailed reference viewed: 10 (3 ULg) Impact of strenuous exercise on the release of cardiac biomarkersLE GOFF, Caroline ; MELON, Pierre ; Kaux, Jean-François et alin Biochimica Clinica (2013, May), 37(SS), 545Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured ... [more ▼]Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured by new commercially available high-sensitive methods in subjects un-dergoing the Maasmarathon. Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Methods: Twenty eight subjects (26 ♂, 42.5±11yo) underwent a race of 42.195 kilometers be-tween Visé (Belgium) and Maastricht (The Netherlands). We drowned blood sample before (T0), just after (T1) and three hours after the race (T3). In all patients, cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. The protocol was approved by the ethics committee of the University of Liège (Belgium). All subjects gave their informed consent. All statistical analyses were performed using Medcalc version 8.1 for Windows. p-value <0.01 was regarded as statistically significant. Results: There was a significant difference between hsTnT concentrations at T0 and T1 (p<0.0001), and between T0 and T3 (p<0.001) for NT-proBNP, but not between T1 and T3. This observation appeared only after a strenuous exercise but today this type of exercise is not reproduce easier in a laboratory of sport. Moreover, at this moment, nobody knows if these observations would have cardiac consequences at long terms. Conclusions: Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death. [less ▲]Detailed reference viewed: 29 (7 ULg) Determination of urinary metanephrine, normetanephrine and methoxymetanephrine by liquid chromatography-electrospray tandem mass spectrometry.LE GOFF, Caroline ; PEETERS, Stéphanie ; NETCHACOVITCH, Matthieu et alin Biochimica Clinica (2013, May), 37(SS), 316Background: The aim of this work was to develop and validate a method for the determination of metanephrine (M), normetanephrine (NM) and methoxymetanephrine (METHO) in urine by liquid chromatography ... [more ▼]Background: The aim of this work was to develop and validate a method for the determination of metanephrine (M), normetanephrine (NM) and methoxymetanephrine (METHO) in urine by liquid chromatography-tandem mass spectrometry (LCMS-MS) on the Triple Quad TQ 5500 from AB SCIEX. In fact, the determination of M and NM concentrations is used in clinical diagnosis of pheochromocytoma, a rare but potentially fatal tumor arising primarily from the chromaffin cells of the adrenal medulla. Methods: The samples were made of 24 hours acidified urines after centrifugation. Sample preparation was performed by hydrolysing and purifying by extraction column. After that, labeled M, NM and METHO were added as internal standard. Samples were analysed by liquid chromatography-electrospray tandem mass spectrometry. We determined the repeatability, reproducibility, accuracy profile and recovery on pooling urines samples from 9 volunteers analysed in triple run. Results: The results of the precision evaluation are shown in table. The repeatability did not exceed 8.4 % for M, 6.8% for NM and 10.8% for METHO. The concentration range was 71-781 µg/24h, 71-853 µg/24h and 20-854µg/24h for the M, NM and METHO respectively. The total precision did not exceed 12.5%, 11.8% and 8.8% for M, NM and METHO. The limit of quantification (LOQ) were 33.77µg/24h, 14.49µg/24H and 19.81 µg/24H for M, NM and METHO respectively. The accuracy varied from 99.69 to 100.2% for a range of 71 to 781 µg/24h, from 93.32 to 100.2% for a range of 71-853 µg/24h and from 99.85 to 100.6% for the range 20-854µg/24h for M, NM and METHO respectively. The recovery were 99.96% (95% CI for the mean: 96.5-103.4), 99.75% (96.5-102.9) and 100.08 (95.97-104.2) for the M, NM and METHO respectively. Conclusions: We have successfully developed and validated an LCMS-MS method to determine urinary M, NM and METHO on the TQ 5500 from AB SCIEX. It represents a convincing alternative to the HPLC method for a faster and reliable measurement of urinary M, NM and METHO. [less ▲]Detailed reference viewed: 22 (1 ULg) MDRD VERSUS CKD-EPI EQUATIONS TO ESTIMATE GLOMERULAR FILTRATION RATE IN OBESE PATIENTSBOUQUEGNEAU, Antoine ; CAVALIER, Etienne ; Krzesinski, Jean-Marie et alin Nephrology Dialysis Transplantation (2013, April 18), 28(supplément 1), 117-139Introduction and Aims: Obesity is recognized as a risk factor both for the development and progression of chronic kidney disease (CKD). Estimating glomerular filtration rate (GFR) is thus especially ... [more ▼]Introduction and Aims: Obesity is recognized as a risk factor both for the development and progression of chronic kidney disease (CKD). Estimating glomerular filtration rate (GFR) is thus especially important to follow these patients. We have tested the performances of two creatinine-based equations, namely the MDRD and CKD-EPI equations, in an obese population. Conclusions :Both in the global and subgroup analyses, the CKD-EPI equation did not outperform the MDRD study equation. The performances of both equations were worse in CKD patients. These two conclusions were still valid if indexed GFR was considered. [less ▲]Detailed reference viewed: 16 (1 ULg) Effect of a single oral loading dose of 100,000 IU of cholecalciferol on serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations in healthy subjectsLAURENT, Terry ; LUKAS, Pierre ; ROUSSELLE, Olivier et alin Osteoporosis International (2013, April), 24(S1), 279Detailed reference viewed: 19 (1 ULg) Changes in the structure and the symptoms of the osteoarthritis knee and prediction of future knee replacement over an 8-year follow-up periodBruyère, Olivier ; Cooper, Cyrus; Pavelka, Karel et alin Osteoporosis International (2013, April), 24(Suppl.1), 209Detailed reference viewed: 25 (12 ULg) Superior Renal Function Sustained for 24 Months through Early Everolimus-Facilitated Reduction of Tacrolimus Versus Standard Tacrolimus in De Novo Liver Transplant Recipients: Results of a Randomized Trial.De Simone, Pierre; DETRY, Olivier ; Kintmalm, G et alin American Journal of Transplantation (2013, April), 13(S5), 169450mTOR inhibitors have the potential to reduce calcineurin inhibitor nephrotoxicity by minimizing or eliminating the need for their use. The 12 month (M) results of H2304 (NCT00622869) study demonstrated ... [more ▼]mTOR inhibitors have the potential to reduce calcineurin inhibitor nephrotoxicity by minimizing or eliminating the need for their use. The 12 month (M) results of H2304 (NCT00622869) study demonstrated superior renal function with everolimus (EVR) plus reduced tacrolimus (rTAC) vs. standard TAC (TAC-C) in de novo liver transplant recipients (LTxR). Presented here are 24M renal function results. For this 24M, multicenter, open-label study 719 de novo LTxR were randomized (1:1:1) after a 30-day (±5 days) run-in period with TAC (±mycophenolate mofetil), to receive either EVR (C0 3-8 ng/mL) with rTAC (C0 3-5 ng/mL; EVR+rTAC, N=245) or EVR (C0 6-10 ng/mL) with TAC withdrawal (TAC-WD; N=231) at M4 or TAC-C (C0 6-10 ng/mL; TAC-C, N=243); all patients received corticosteroids. Enrollment in TAC-WD arm was stopped early due to higher rejection rates. Main endpoints at M24 included composite ef􏰀cacy failure rate of treated biopsy proven acute rejection, graft loss or death, and evolution of renal function from randomization (RND) to M24 measured as eGFR by MDRD4. At M24, composite ef􏰀cacy failure rate in EVR+rTAC arm was comparable to TAC-C (10.3% vs. 12.5%, p=0.452). Evolution of renal function from RND to M24 was superior for EVR+rTAC vs. TAC-C with an adjusted mean difference in eGFR change of 6.66 mL/min/1.73m2 (p=0.0018; ITT population). Signi􏰀cantly higher eGFR with EVR+rTAC was achieved at M2 post-LTx and was maintained until M24. On-treatment data showed a decrease in mean eGFR from RND to M24 of 6.6 mL/min/1.73m2 with EVR+rTAC vs. 13 mL/min/1.73m2 with TAC-C and 2.5 mL/ min/1.73m2 gain with TAC-WD. Urinary protein:creatinine ratio (mg/g) at M24 was higher with EVR+rTAC vs. TAC-C (Mean±SD: 194±280 vs. 159±284, p=0.006). Early introduction of EVR at 1M post-LTx with rTAC showed superior renal function sustained for 24M compared to TAC-C, without compromising ef􏰀cacy in de novo LTxR. [less ▲]Detailed reference viewed: 21 (1 ULg) Role of nutraceuticals in the symptomatic and structural management of osteoarthritisBruyère, Olivier in Osteoporosis International (2013, April), 24(Suppl.1), 82-83Detailed reference viewed: 13 (0 ULg) Effect of a single oral loading dose of 100,000 IU of cholecalciferol on bone biomarkers in healthy dults subjectsLAURENT, Terry ; LUKAS, Pierre ; ROUSSELLE, Olivier et alin Osteoporosis International (2013, April), 24(S1), 329Detailed reference viewed: 2 (0 ULg) What is the predictive value of MRI for the occurrence of hard clinical endpoints in knee osteoarthritis?Pelletier, Jean-Pierre; Peterfy, Charles; Brandi, Maria Luisa et alin Osteoporosis International (2013, April), 24(Suppl.1), 84-85Detailed reference viewed: 7 (0 ULg) Effect of a single oral loading dose of 100,000 IU of cholecalciferol on phosphocalcic metabolism biomarkers in healthy adults subjectsLAURENT, Terry ; LUKAS, Pierre ; ROUSSELLE, Olivier et alin Osteoporosis International (2013, April), 24(S1), 282Detailed reference viewed: 5 (1 ULg) Clinical characteristics of patients responsive to whole body vibrationBeaudart, Charlotte ; Buckinx, Fanny ; Maquet, Didier et alin Osteoporosis International (2013, April), 24(Suppl.1), 243Detailed reference viewed: 27 (7 ULg) Effects of chondroitin sulfate on the gene expression profile in IL-1β stimulated synovial fibroblast cells culturesLambert, Cécile ; Dubuc, Jean-Emile; Montell, E. et alin Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. In this study, we performed a microarray analysis and identified a differential expression profile between control ... [more ▼]Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. In this study, we performed a microarray analysis and identified a differential expression profile between control and IL-1β stimulated synovial fibroblast cells cultures. In a second step, we investigated the effects of CS on this gene expression profile. Methods: OA synovial specimens were obtained from 12 patients undergoing knee replacement. At the surgery time, the synovial membrane was dissected. Synovial fibroblast cells (SFC) were enzymatically isolated and used after four passages (P4). SFC were pre-treated 1 hour with highly purified bovine CS (200 µg/ml, Bioibérica S.A., Barcelona, Spain) before treatment with IL-1β (1 ng/ml) for 24 hours. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class comparison test between control (Ctl) and interleukin (IL)-1β conditions, Ctl and Ctl/CS and IL-1β and IL-1β/CS conditions was based on paired t-test where Ctl and IL-1β, Ctl and Ctl/CS and IL-1β and IL-1β/CS were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Probes with a p-value below 0.001 were chosen and classified as up- or down-regulated ones. Results: 3308 genes were identified as differentially expressed genes between Ctl and IL-1β conditions. We observed a differential profile of expression of major pathways involved in OA pathogenesis. The key identified pathways were related to inflammation, complement cascade, angiogenesis, cartilage catabolism and anabolism and Wnt signaling. In the inflammatory network, the most upregulated cytokines were IL-8 and IL-6 with a fold change of 156.25 and 58.8 respectively. We also identified several chemokines, enzymes and metallothioneins (MTs). Complement factor B (CFB) and complement component 3 (C3) are two factors upregulated in the inflammatory complement cascade. We also identified some genes implicated in the angiogenesis pathway. The most upregulated was Stanniocalcin 1 (STC1) with a fold change of 9.09. The differential expression of intermediates involved in both cartilage anabolism and catabolism was revealed by the IL-1β stimulation, showing an imbalance in favour of catabolism. MMP-3 was largely upregulated (fold change of 62.5). Wnt 5A and low density lipoprotein receptor-related protein (LRP8) were significantly upregulated while frizzled homolog 2 (FZD2) and dickkopf homolog 3 (DKK3) were downregulated in the Wnt signaling pathway. We next performed a class comparison test between Ctl and Ctl/CS in one hand and IL-1β and IL-1β/CS on the other hand. 660 genes were identified as differentially expressed between Ctl and Ctl/CS conditions while 241 genes were identified between IL-1β and IL-1β/CS. Among them, our attention was focused on two genes upregulated in the presence of CS: lysyl oxidase-like 4 (LOXL4) and claudin 11 (CDLN11), two genes that negatively regulate cell invasion. Conclusions: We here evidenced in synovial fibroblast cells the modulation of gene expression following IL-1β stimulation. We also demonstrated the modulatory effects of CS on gene expression and isolated several CS-modulated genes of interest such as LOXL4 and CDLN11, which could constitute new mechanisms of action of the molecule and contribute to explain the symptomatic efficacy of CS in the treatment of OA. [less ▲]Detailed reference viewed: 38 (1 ULg) Reproducibility of joint space width assessment when external calibration on the radiograph is missingDEROISY, Rita ; Reginster, Jean-Yves ; Bruyère, Olivier in Osteoporosis International (2013, April), 24(Suppl.1), 379Detailed reference viewed: 7 (0 ULg) Quantitative gait assessment using an accelerometer technology as a predictive tool of falls among nursing home residents: a 6-month prospective studyBruyère, Olivier ; Detalle, Anne-Sophie; Demonceau, Marie et alin Osteoporosis International (2013, April), 24(Suppl.1), 210Detailed reference viewed: 11 (3 ULg) Health economics in osteoarthritisHiligsmann, Mickaël ; Cooper, Cyrus; Arden, Nigel et alin Osteoporosis International (2013, April), 24(Suppl.1), 79-80Detailed reference viewed: 8 (1 ULg) Investigation of potential new targets for the diagnosis and/or the treatment of osteoarthritisLambert, Cécile ; Dubuc, J.-E.; Montell, E. et alin Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), Purpose: Synovial inflammation plays a key role in the pathophysiology process of osteoarthritis (OA). We have previously compared the gene expression pattern of synovial cells isolated from inflammatory ... [more ▼]Purpose: Synovial inflammation plays a key role in the pathophysiology process of osteoarthritis (OA). We have previously compared the gene expression pattern of synovial cells isolated from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same OA patient. We identified a large number of mediators belonging to key pathways involved in OA pathogenesis. The aim of this study was to validate different potential new targets for the diagnosis and/or the treatment OA. Methods: Synovial cells (SC) were isolated from synovial specimens obtained from OA patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria. The biopsies from N/R and I areas were cultured separately for a period of 7 days. Microarray gene expression profiling between N/R and I areas was performed. The biological relevance of up- and down-regulated genes was analyzed with Ingenuity Pathways Analysis. Western blot and immunohistochemistry confirmed the identified genes most differentially expressed in the key pathways. The production of the triggering receptor expressed on myeloid cells-1 (TREM1), the alarmin S100 calcium binding protein A9 (S100A9), the wingless-type MMTV integration site family, member 5A (Wnt-5A) and the stanniocalcin 1 (STC1) were evaluated by Western blot. S100A9, hyaluronan synthase-1 (HAS1) and STC1 expression and localization were investigated by immunohistochemistry. Results: 896 genes differentially expressed in N/R and I areas were identified. The key pathways were related to inflammation, cartilage metabolism, Wnt signaling and angiogenesis. In the inflammatory gene pattern, TREM1 and S100A9 were strongly upregulated. We validated the production of these proteins in OA synovial biopsies by Western blot. TREM1 and S100A9 were increased in I compared to N/R synovial cells culture. S100A9 was observed in the perivascular area and in sublining cells in I synovial biopsies, but not in N/R biopsies. An increased staining was also observed in the intima lining layer of I when compared to N/R biopsies. The most upregulated anabolism enzyme in I synovial biopsies was HAS1. Using immunohistochemistry, we observed in I areas an increase of the HAS1-positive cells mainly in the intima lining. We also studied the protein production of Wnt-5A, the most upregulated intermediate of Wnt signaling pathway. The protein level was increased in I compared to N/R areas. Finally, in the angiogenesis pathway, one the most u-regulated gene was STC1. A significant increase of STC1 production was observed in I areas compared to N/R areas by Western blot. This result was also supported by the immunohistochemical analysis. In I area, the staining for STC1 was more intense in perivascular and sublining cells. Conclusions: Synovial membrane inflammation is a key target for OA treatments. In this work, we have identified proteins involved in the synovitis pathways like angiogenesis, cells infiltration and matrix remodeling. These proteins could be targeted by drugs and used as companion biomarkers for evaluating their efficacy. Although qualitative, our results could also yield to the identification of markers of the disease. This investigation has to be further pursued. [less ▲]Detailed reference viewed: 59 (4 ULg) Planet TOPERS: Planets, Tracing the Transfer, Origin, Preservation, and Evolution of Their ReservoirsDehant, V.; Van Hoolst, T.; Breuer, D. et alin Geophysical Research Abstracts (2013, April), 15An overview is given of the Planet TOPERS project addressing habitability in our solar system.Detailed reference viewed: 14 (4 ULg) Nonpharmacological managementBruyère, Olivier in Osteoporosis International (2013, April), 24(Suppl.1), 76Detailed reference viewed: 3 (0 ULg) Strontium ranelate improves osteoarthritis symptoms compared to placebo in patients with knee OA: The SEKOIA studyBruyère, Olivier ; Richette, P; Bellamy, N et alin Osteoporosis International (2013, April), 24(Suppl.1), 49-51Detailed reference viewed: 29 (4 ULg) Evaluation of the impact of a 6-month training by whole body vibration on the risk of falls among nursing home residentsBeaudart, Charlotte ; Buckinx, Fanny ; Demonceau, Marie et alin Osteoporosis International (2013, April), 24(Suppl.1), 246-247Detailed reference viewed: 24 (10 ULg) Effects of chondroitin sulfate on the gene expression profile in the inflamed synovial membraneLambert, Cécile ; Dubuc, J-E; Montell, E. et alin Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a ... [more ▼]Purpose: The aim of the present work was to identify the differentially expressed genes between the inflammatory (I) and normal/reactive (N/R) synovial areas using a unique ex vivo culture model. In a second step, we investigated the genetic modulatory effects of chondroitin sulfate (CS) in this model. Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days in the absence or in the presence of highly purified bovine CS (200 µg/ml, Bioibérica S.A., Barcelona, Spain). Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I conditions, N/R and N/R-CS conditions and I and I-CS conditions was based on paired t-test where N/R and I, N/R and N/R-CS and I and I-CS were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Results: From among 47000 probes, 18253 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 465 differentially expressed genes between N/R and I areas were identified. Many inflammatory mediators appear differentially expressed. The interferon alpha-inductible protein 6 (IFI6) was the most up-regulated. We also identified the hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), the cathepsin K (CTSK), the chemokine (C-X-C motif) ligand 1 (CXCL1) and the EBV-induced G-protein coupled receptor 2 (EBI2). The differential expression of intermediates involved in angiogenesis pathway was also revealed between N/R and I areas. Among them, R-spondin-3 (RSPO3), the secreted phopshoprotein 1 (SPP1) and aquaporin 9 (AQP9) were up-regulated whereas ADAMTS1 was down-regulated. Finally, in the Wnt signaling, RSPO3 was up-regulated unlike dickkopf homolog 3 (DKK3) which was in turn down-regulated. We next performed a class comparison test between N/R and N/R-CS in one hand and between I and I-CS the other hand. 489 genes were identified as differentially expressed genes between N/R and N/R-CS conditions while 219 genes were identified between I and I-CS conditions. In this latter, our attention was focused on the down-regulated genes. Among them, we identified a number implicated in angiogenesis and cell migration pathways. Thus, the endothelial cell-specific molecule-1 (ESM1), the Transmembrane-4-L-six-family-1 (TM4SF1), the 5’-Ectonucleotidase (NT5E) and the growth arrest-specific gene 6 (GAS6) were down-regulated by CS. Conclusions: Our work demonstrates the differential gene expression profile between paired non inflammatory and normal/reactive areas of synovial membrane as well as the modulatory effects of CS on gene expression in the inflammatory areas, especially regarding genes involved in both angiogenesis and cell migration. [less ▲]Detailed reference viewed: 35 (1 ULg) Cost-effectiveness of vitamin D and calcium supplementation in the treatment of postmenopausal womenHiligsmann, Mickaël ; Ben Sedrine, Wafa ; Rabenda, Véronique et alin Osteoporosis International (2013, April), 24(Suppl.1), 198Detailed reference viewed: 13 (1 ULg) What is the value of biomarkers for drug development in osteoarthritis?Lotz, Martin; Martel-Pelletier, Johanne; Christiansen, Claus et alin Osteoporosis International (2013, April), 24(Suppl.1), 77-78Detailed reference viewed: 10 (2 ULg) Equivalence of a single dose (1200mg) compared to a 3-time a day dose (400mg) of chondroitin 4&6 sulfate in patients with knee osteoarthritis: Results of a randomized double blind placebo controlled studyZegels, Brigitte ; LEONORI, Lorenzo ; Crozes, P et alin Osteoporosis International (2013, April), 24(Suppl.1), 383Detailed reference viewed: 15 (7 ULg) OARSI recommended performance-based tests to assess physical function in people with established hip and knee osteoarthritisDobson, F.; Hinman, R.S.; Roos, E.M. et alin Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), Detailed reference viewed: 16 (0 ULg) Validity of the French hip and knee replacement expectations surveysNEUPREZ, Audrey ; François, Garance ; Delcour, JP et alin Osteoporosis International (2013, April), 24(Suppl.1), 374Detailed reference viewed: 31 (18 ULg) The intra-articular injection of a new chitosan biomaterial prevents the progression of osteoarthritis in ACLT rabbit modelOprenyeszk, Frédéric ; Chausson, Mickael; Maquet, Véronique et alin Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), 69Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on ... [more ▼]Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on cartilage lesion in osteoarthritis (OA) rabbit model. These effects were compared to those obtained with the intra-articular injection of either chitosan-based (H) hydrogel without the AC bead or saline solution. Methods OA was surgically induced by the transection of the anterior cruciate ligament (ACLT) in HYLA albino rabbits. One week after surgery, animals were randomly divided into 3 groups: group I (n=7): mix of AC beads and H hydrogel; group II (n=7): H hydrogel alone; group III (n=7): saline solution (control). The treatments (900 µl) were injected intra-articularly. X-rays from the right knee were performed before surgery, at the time of injection and at sacrifice. The standard radiographs were acquired in extension and scored by the Kellgren and Lawrence (K&L) scale. After 6 weeks, animals were euthanized and the right joint was dissected. The macroscopic evaluation of cartilage from femoral condyles and tibial plateaus stained with India ink was done. Histological sections stained with Safranine-O/fast green from bearing areas of each compartment were evaluated according to the OARSI histological score. Briefly, the evaluation considered: staining of the cartilage matrix (0-6), cartilage structure (0-11), chondrocyte density (0-4) and cluster formation (0-3), where 0 represented a normal situation and 24 points the maximum severity score. Blood samples were collected the day of injection and prior the sacrifice. Prostaglandin E2 (PGE2) and C-reactive protein (CRP) were measured in serum using immunoassays. Results The X-rays analysis showed a significant decrease (p <0.05) of the K&L score in group I (AC beads and H hydrogel; 1.5 ± 0.2) compared with group II (H hydrogel; 2.2 ± 0.5) and group III (saline solution; 3.0 ± 0.4). The size and the severity of the macroscopic OA cartilage lesion tended to decrease in group I compared to the other groups. The histological global score that refers to all compartments of the knee joint was significantly decreased in group I (11.0 ± 0.7) compared to group II (14.4 ± 0.6, p <0.01) and group III (14.8 ± 0.6, p <0.001). No significant variation of PGE2 and CRP serum levels were observed in each after 6 weeks follow-up whatever the treatment injected. Conclusions This study showed that a biphasic hydrogel composed by AC beads and H hydrogel prevented OA in rabbit with ACL transection. This effect was not observed with the hydrogel alone, suggesting that AC beads play a role in joint protection. The preventive effect was observed in all joint compartments indicating a global protective effect of this new viscosupplementation. [less ▲]Detailed reference viewed: 29 (3 ULg) Quality of life in sarcopenia and frailtyRizzoli, René; Reginster, Jean-Yves ; Arnal, Jean-François et alin Osteoporosis International (2013, April), 24(Suppl.1), 76-77Detailed reference viewed: 31 (13 ULg) Mode lifetime and associated scaling relationsBelkacem, K.; Appourchaux, T.; Baudin, F. et alin EPJ Web of Conferences (2013, March 01), 43Thanks to the CoRoT and Kepler spacecrafts, scaling relations (linking seismic indices and global stellar parameters) are becoming the cornerstone of ensemble asteroseismology. Among them, the relation ... [more ▼]Thanks to the CoRoT and Kepler spacecrafts, scaling relations (linking seismic indices and global stellar parameters) are becoming the cornerstone of ensemble asteroseismology. Among them, the relation between the cut-off frequency and the frequency of the maximum in the power spectrum of solar-like pulsators as well as the relation between mode lifetime and the effective temperature remain poorly understood. However, a solid theoretical background is essential to assess the accuracy of those relations and subsequently of the derived stellar parameters. We will thus present recent advances on the understanding of the underlying mechanisms governing those relations and show that the physics of mode lifetime (thus of mode damping) plays a major role. [less ▲]Detailed reference viewed: 7 (0 ULg) Amplitudes of solar-like oscillations in red giants: Departures from the quasi-adiabatic approximationSamadi, R.; Belkacem, K.; Dupret, Marc-Antoine et alin European Physical Journal Web of Conferences (2013, March 01), 43CoRoT and Kepler measurements reveal us that the amplitudes of solar-like oscillations detected in red giant stars scale from stars to stars in a characteristic way. This observed scaling relation is not ... [more ▼]CoRoT and Kepler measurements reveal us that the amplitudes of solar-like oscillations detected in red giant stars scale from stars to stars in a characteristic way. This observed scaling relation is not yet fully understood but constitutes potentially a powerful diagnostic about mode physics. Quasi-adiabatic theoretical scaling relations in terms of mode amplitudes result in systematic and large differences with the measurements performed for red giant stars. The use of a non-adiabatic intensity-velocity relation derived from a non-adiabatic pulsation code significantly reduces the discrepancy with the CoRoT measurements. The origin of the remaining difference is still unknown. Departure from adiabatic eigenfunction is a very likely explanation that is investigated in the present work using a 3D hydrodynamical model of the surface layers of a representative red giant star. [less ▲]Detailed reference viewed: 9 (0 ULg) Non-radial, non-adiabatic solar-like oscillations in RGB and HB starsGrosjean, Mathieu ; Dupret, Marc-Antoine ; Belkacem, K. et alin EPJ Web of Conferences (2013, March 01), 43CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in ... [more ▼]CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in the same region of the HR diagram but in different evolutionary phases. We present here our first results on the inertia, lifetimes and amplitudes of the oscillations and discuss the differences between the two stars. [less ▲]Detailed reference viewed: 13 (7 ULg) Red giants rotational splittingsOuazzani, R. M.; Goupil, M. J.; Dupret, Marc-Antoine et alin EPJ Web of Conferences (2013, March 01), 43The space missions CoRoT and Kepler provide high quality data that allow to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. Our aim is to ... [more ▼]The space missions CoRoT and Kepler provide high quality data that allow to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. Our aim is to test the validity of the seismic diagnostics for red giant rotation that are based on a perturbative method and to investigate the oscillation spectra when the validity does not hold. We use a non-perturbative approach implemented in the ACOR code [1] that accounts for the effect of rotation on pulsations, and solves the pulsations eigenproblem directly for dipolar oscillation modes. We find that the limit of the perturbation to first order can be expressed in terms of the core rotation and the period separation between consecutive dipolar modes. Above this limit, each family of modes with different azimuthal symmetry m, has to be considered separately. For rapidly rotating red giants, new seismic diagnostics can be found for rotation by exploiting the differences between the period spacings associated with each m-family of modes. [less ▲]Detailed reference viewed: 5 (0 ULg) Belgian multicentre experience with intestinal transplantationCeulemans, L; DE ROOVER, Arnaud ; DETRY, Olivier et alin Acta Gastro-Enterologica Belgica (2013, March), 76(1), 07Detailed reference viewed: 18 (3 ULg) The empirical mass distribution of hot B subdwarfs: implications for stellar evolution theoryVan Grootel, Valérie ; Fontaine, Gilles; Charpinet, Stéphane et alin EPJ Web of Conferences (2013, March), 43Subdwarf B (sdB) stars are hot, compact, and evolved objects that form the very hot end of the horizontal branch, the so-called Extreme Horizontal Branch (EHB). Understanding the formation of sdB stars is ... [more ▼]Subdwarf B (sdB) stars are hot, compact, and evolved objects that form the very hot end of the horizontal branch, the so-called Extreme Horizontal Branch (EHB). Understanding the formation of sdB stars is one of the remaining challenges of stellar evo- lution theory. Several scenarios have been proposed to account for the existence of such objects, made of He-burning core surrounded by very thin H-rich envelope. They give quite different theoretical mass distributions for the resulting sdB stars. Detailed astero- seismic analyses, including mass estimates, of 15 pulsating hot B subdwarfs have been published since a decade. The masses have also been reliably determined by light curve modeling and spectroscopy for 7 sdB components of eclipsing and/or reflection effect binaries. These empirical mass distributions, although based on small-number statistics, can be compared with the expectations of stellar evolution theory. In particular, the two He white dwarfs merger scenario does not seem to be the dominant channel to form iso- lated sdB stars, while the post-red giant branch scenario is reinforced. This opens new questions on extreme mass loss of red giants to form EHB stars, possibly in connection with the recently discovered close substellar companions and planets orbiting sdB stars. [less ▲]Detailed reference viewed: 31 (6 ULg) Stockage de bois chablis sous bâcheCastaings, Frédéric; Jourez, Benoît ; Riguelle, Simon in Infos de RND (Les) (2013, March), (1er semestre), 3-5Le samedi 24 janvier 2009, la tempête Klaus traverse le sud-ouest de la France. Tempête la plus dévastatrice depuis 1999, la forêt des Landes et ses pins maritimes paient un lourd tribut à ce phénomène ... [more ▼]Le samedi 24 janvier 2009, la tempête Klaus traverse le sud-ouest de la France. Tempête la plus dévastatrice depuis 1999, la forêt des Landes et ses pins maritimes paient un lourd tribut à ce phénomène extrême: 60% de la superficie est touchée, environ 40 millions de m3 de bois sont à terre, quatre fois la récolte annuelle. Il faudra attendre plusieurs mois avant que les aires de stockage par aspersion soient opérationnelles. Trop tard, le pin maritime montre déjà des signes de bleuissement de son bois, il est invendable sur les marchés à forte valeur ajoutée, là où l’esthétisme prime. Écarté des meilleurs débouchés, le lambris et le plancher, le manque à gagner est énorme. Un tel scénario catastrophe, notre région s’y prépare depuis 2005, tirant les enseignements des expériences étrangères et fondant son action sur les spécificités de notre forêt, de notre filière. C’est dans ce cadre que le 28 février dernier, à Eupen, des grumes d’épicéa stockées depuis presque cinq ans ont été extraites des bâches hermétiques qui les protégeaient. Comment le bois est-il ressorti de cette épreuve? Que penser de cette méthode alternative de stockage? Quelle place lui réserver ? Benoit Jourez du Laboratoire de Technologie du Bois du DEMNA (Département de l’Étude du milieu naturel et agricole) nous a apporté son éclairage et nous a conviés à l’ouverture de la poche étanche. Entre supputations et réalité des bois extraits après cinq ans, suspense… [less ▲]Detailed reference viewed: 18 (5 ULg) An overview of white dwarf starsFontaine, Gilles; Brassard, Pierre; Charpinet, Stéphane et alin EPJ Web of Conferences (2013, March), 43We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of ... [more ▼]We present a brief summary of what is currently known about white dwarf stars, with an emphasis on their evolutionary and internal properties. As is well known, white dwarfs represent the end products of stellar evolution for the vast majority of stars and, as such, bear the signatures of past events (such as mass loss, mixing phases, loss and redistribution of angular momentum, and thermonuclear burning) that are of essential importance in the evolution of stars in general. In addition, white dwarf stars represent ideal testbeds for our understanding of matter under extreme conditions, and work on their constitutive physics (neutrino production rates, conductive and radiative opacities, interior liquid/solid equations of state, partially ionized and partially degenerate envelope equations of state, diffusion coefficients, line broadening mechanisms) is still being actively pursued. Given a set of constitutive physics, cooling white dwarfs can be used advantageously as cosmochronometers. Moreover, the field has been blessed by the existence of four distinct families of pulsating white dwarfs, each mapping a different evolutionary phase, and this allows the application of the asteroseismological method to probe and test their internal structure and evolutionary state. We set the stage for the reviews that follow on cooling white dwarfs as cosmochronometers and physics laboratories, as well as on the properties of pulsating white dwarfs and the asteroseismological results that can be inferred. [less ▲]Detailed reference viewed: 26 (3 ULg) Asteroseismology of hot B subdwarf starsCharpinet, Stéphane; Van Grootel, Valérie ; Brassard, Pierre et alin EPJ Web of Conferences (2013, March), 43Nonradial pulsations in Extreme Horizontal Branch stars (also known as hot B subdwarfs or sdB stars) offer strong opportunities to study through asteroseismology the structure and internal dynamics of ... [more ▼]Nonradial pulsations in Extreme Horizontal Branch stars (also known as hot B subdwarfs or sdB stars) offer strong opportunities to study through asteroseismology the structure and internal dynamics of stars in this intermediate stage of stellar evolution. Most sdB stars directly descend from former red giants and are expected to evolve straight into white dwarfs after core helium exhaustion. They thus represent the most direct link between these two stages. Their properties should therefore reflect both the outcome of the core evolution of red giant stars and the initial state for a fraction of the white dwarfs. We review the status of this field after a decade of efforts to exploit both p-mode and g-mode pulsating sdB stars as asteroseismic laboratories. From the discoveries of these two classes of pulsators in 1997 and 2003, respectively, up to the current epoch of data gathering of unprecedented quality from space, a lot of progress has been made in this area and prospects for future achievements look very promising. [less ▲]Detailed reference viewed: 18 (5 ULg) Différences d’activité de l’inflammasome NLRP3 entre sujets obèses avec et sans anomalies métaboliquesEsser, Nathalie ; L'Homme, Laurent ; DE ROOVER, Arnaud et alin Diabètes & Métabolism (2013, March), 39(suppl 1), 102Detailed reference viewed: 17 (9 ULg) Development of an experimental device allowing plant-plant interaction studies and in situ dynamic trapping of volatile organic compounds emitted by barley (Hordeum distichon L.) rootsDelory, Benjamin ; Delaplace, Pierre ; Fauconnier, Marie-Laure et alin Communications in Agricultural and Applied Biological Sciences (2013, February 08), 78(1), 97-102In response to wounding or herbivore attack, leaves and roots of higher plants release volatile organic compounds (VOCs). To date, VOCs analysis and plant−plant interaction studies have been mainly ... [more ▼]In response to wounding or herbivore attack, leaves and roots of higher plants release volatile organic compounds (VOCs). To date, VOCs analysis and plant−plant interaction studies have been mainly performed on aboveground plant tissues, leaving the roles played by root VOCs in plant−plant interaction unexplored. In this context, this project aims at setting up an original experimental device allowing both dynamic trapping of VOCs emitted by mechanically damaged H. distichon roots and the study of the roles played by root VOCs in intra and interspecific plant−plant interactions. The experimental device consists of Barley seedlings cultivated in closed PTFE reactors filled with wet sand. Before being analysed by gas chromatography−mass spectrometry, root VOCs are trapped via a dynamic system on Tenax cartridges using a charcoal-filtered and humidified air. Preliminary results show that 7 day-old wounded Barley roots emit C9 fatty acid derivatives (E-non-2-enal and nona-2,6-dienal) as major compounds, contrasting with aboveground plant tissues that mainly emit C6 alcohols, aldehydes, and their derivative esters. For plant−plant interaction studies, receiver plants are exposed to an airflow enriched with VOCs from root damaged Barley plants of the same age. [less ▲]Detailed reference viewed: 97 (28 ULg) Long term measurements of volatile organic compounds exchanges above a maize field at Lonzee (Belgium)Bachy, Aurélie ; Aubinet, Marc ; SALERNO, Giovanni et alin Communications in Agricultural and Applied Biological Sciences (2013, February), 78(1), 127-132VOC (volatile organic compounds) include a wide set of molecules which are mostly emitted by the plants. Atmospheric scientists are strongly interested in these compounds because of their important role ... [more ▼]VOC (volatile organic compounds) include a wide set of molecules which are mostly emitted by the plants. Atmospheric scientists are strongly interested in these compounds because of their important role in the atmospheric chemistry and their final impact on air pollution and climate change. Evaluation of current and future VOC emissions is thus necessary and requires a comprehensive understanding of VOC production and exchange dynamics under a wide panel of climatic conditions and ecosystems. Forest and non pastured grasslands have been largely studied for the last decade. However, knowledge about VOC fluxes from croplands remains scarce. Our study focuses on the VOC exchanges between a maize field and the atmosphere. It is incorporated in a wider project that aims to study VOC fluxes from two croplands (maize and winter wheat) and a pastured grassland. VOC fluxes have been measured on a maize field during the whole growing season using a micrometeorological method (eddy covariance). While first results show half-hourly bidirectionnal exchanges among all the preselected compounds, in average methanol stands for the greatest emitted VOC, followed by green leaf volatiles, and acetic acid is the greatest taken up VOC. Small isoprene and monoterpenes fluxes are also observed. A diurnal pattern is found for all those VOC, with greater emission/uptake during the day, suggesting a flux dependence on environmental parameters. These environmental controls will be further investigated [less ▲]Detailed reference viewed: 103 (13 ULg) Therapeutic Strategy and Patient Outcome during the First 2 Years of Pediatric Crohn’s DiseaseVeereman, G; Mahachie John, Jestinah ; De Greef, E et alin Acta Gastroenterologica Belgica (2013, February)Detailed reference viewed: 9 (0 ULg) Development of a test to assess the Banana Bunchy Top Virus transmissibility through direct analysis of its aphid vector Pentalonia nigronervosaDe Clerck, Caroline ; Francis, Frédéric ; Lepoivre, Philippe et alin Communications in Agricultural and Applied Biological Sciences (2013, February), 78(1), 49-54Detailed reference viewed: 53 (11 ULg) Collaborations distantes synchrones dans les pratiques de conceptionBen Rajeb, Samia; Leclercq, Pierre in International Journal of Design Sciences and Technology (2013, January)Cet article propose une analyse des pratiques de la collaboration architecturale dans des situations de travail distantes. Il s'intéresse en particulier à la mise en oeuvre d'outils pour le travail ... [more ▼]Cet article propose une analyse des pratiques de la collaboration architecturale dans des situations de travail distantes. Il s'intéresse en particulier à la mise en oeuvre d'outils pour le travail synchrones dans les agences d'architecture. Il s'appuie sur l'observations in situ de trois situations qui illustrent successivement différents modes d'interaction : nous analyserons ainsi l'usage de la visioconférence, de l'écran partagé puis du studio distant collaboratif. Pour identifier quels rôles peuvent assurer ces différents outils numériques, notre méthodologie s'appuiera sur la catégorisation proposée par les concepts architecturologiques, décrivant les opérations de conception architecturale, complétées des opérations pragmatiques de collaboration. Une grille évaluative des opérations supportées respectivement par ces trois technologies identifiera leurs limitations, atouts et conditions d'opérabilité, permettant ainsi d'apprécier la mise en oeuvre actuelle et future des technologies collaboratives en agence d'architecture. [less ▲]Detailed reference viewed: 73 (33 ULg) Erythropoietin therapy after allogeneic hematopoietic cell transplantation : a prospective randomised trial.JASPERS, Aurélie ; Baron, Frédéric ; WILLEMS, Evelyne et alin Belgian Journal of Hematology (2013, January)Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO ... [more ▼]Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO) therapy was very efficient when started one month after transplantation. We also demonstrated that anemia after nonmyeloabalative (NM) HCT was less sensitive to rhEPO therapy than after conventional allogeneic HCT. This prompted us to confirm these findings in a prospective randomised trial. One hundred and thirty-one patients were randomised (1:1) between no treatment (arm 1) or erythropoietin (Neorecormon) at the dose of 500 U/kg/week (arm 2). Once the target Hb (13g/dL) has been attained, the dose of rhEPO was reduced by half, while it was withheld when Hb was = 14g/dL. Cohort A included 42 patients on day 28 after myeloablative HCT, cohort B 39 patients on day 28 after NMHCT, and cohort C 50 patients on day 0 of NMHCT. Primary endpoints included proportion of complete correctors (i.e. patients reaching Hb = 13g/dL) and median time to achieve Hb correction in each arm. The proportion of complete correctors before day 126 posttransplant was 0% in group 1A vs 52.4% in group 2A, 0% in group 1B vs 69.5% in group 2B and 19.1% in group 1C vs 70.2% in group 2C. Median time to achieve Hb = 13g/dL was not reached in group 1B vs 49 days in group 2B; 363 and 59 days in groups 1A and 1B respectively and 363 and 87 days in groups 3A and 3B respectively (figure 1). Hb evolution in each group is shown in figure 2. Seventyone patients (47/62 in control groups and 24/57 in treated groups, p=0.0003) required red blood cell transfusions. The difference was most pronounced in cohort B. There was no difference in rates of thrombo-embolic events or other complications between the two arms. In conclusion, this is the first trial to demonstrate that EPO therapy hastens erythroid recovery and decreases transfusion requirements when started one month after allogeneic HCT. [less ▲]Detailed reference viewed: 11 (4 ULg) Experimental and numerical study of TA6V mechanical behavior under different quasi-static strain paths at room temperatureGilles, Gaëtan ; Habraken, Anne ; Cazacu, Oana et alin AIP Conference Proceedings (2013), 1532This paper presents an experimental study of the quasi-static mechanical behavior of TA6V titanium alloy. Different monotonic tests were carried out in several orientations in the plane of the sheet in ... [more ▼]This paper presents an experimental study of the quasi-static mechanical behavior of TA6V titanium alloy. Different monotonic tests were carried out in several orientations in the plane of the sheet in order to characterize the anisotropy and the tension-compression asymmetry exhibited by the material. Initial yielding is modeled by the phenomenological CPB06 criterion and Voce's isotropic hardening is used to describe its evolution. The simulation of a deep-drawing process is performed using the proposed constitutive modeling and compared with experimental data. [less ▲]Detailed reference viewed: 11 (8 ULg) Optimizing scale search in species distribution modelsSerckx, Adeline ; Huynen, Marie-Claude ; Beudels-Jamar, Roseline et alin Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of ... [more ▼]The influence of spatial scale on ecological processes and pattern formation, such as species distribution is a major research topic since decades. It has become even more relevant in the context of global change. In many studies the influence of a predictor on a response derived over multiple and discrete spatial scales is evaluated. Due to inherent issue of multiple testing, this approach can be problematic. In this study on bonobos distribution, we suggest a 3-steps procedure that overcomes this problem. It takes into account the decay of a predictor by using a weighting function of distance to the observation of interest. We use variables to account for human pressure, food availability, patchy structure of the forest and nesting sites re-use. In a first step, we run a model with a fixed scale for every predictor based on expert opinion. For significant variables, we derive then in a second step the distance weighted influence over a range of scales. This helps to narrow down the search for the final model parameter estimates. Findings indicate that bonobo distribution is driven on the intermediate scale by forest patches structure. Food availability explains their abundance only at smaller scales. Those results demonstrate the sadly well-known influence of habitat fragmentation on animals’ density and distribution but also highlight the importance to understand influences of scale, the animal perceptions of their environment, by using appropriate statistical procedures. Our method can be particularly useful to formulate specific management hypotheses for conservation. Furthermore, its principles can be of use to other types of studies, such as behavior. [less ▲]Detailed reference viewed: 7 (0 ULg) Strunian Rugose and Tabulate corals from Northwestern TurkeyDenayer, Julien in Document de l'Institut Scientifique, Rabat (2013), 26Detailed reference viewed: 13 (1 ULg) IS ULTRA-SHORT COLD ISCHEMIA THE KEY TO ISCHEMIC CHOLANGIOPATHY AVOIDANCE IN DCD- LT?DETRY, Olivier ; DE ROOVER, Arnaud ; Cheham, Samir et alin Transplant International (2013)Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic ... [more ▼]Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic cholangiopathy leading to graft loss. The authors retrospectively reviewed a single centre experience with DCD-LT in a 9-year period. Patients and Methods: 70 DCD-LT were performed from 2003 to November 2012. All DCD procedures were performed in operative rooms. Median donor age was 59 years. Most grafts were flushed with HTK solution. Allocation was centre-based. Median total DCD warm ischemia was 19.5 min. Mean follow-up was 36 months. No patient was lost to follow-up. Results: Median MELD score at LT was 15. Median cold ischemia was 235 min. Median peak AST was 1,162 U/L. Median peak bilirubin was 31.2 mg/dL. Patient and graft survivals were 92.8% and 91.3% at one year and 79% and 77.7% at 3 years, respectively. One graft was lost due to hepatic artery thrombosis. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Causes of death were malignancies in 8 cases. Discussion: In this series, DCD LT appears to provide results equal to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. [less ▲]Detailed reference viewed: 7 (1 ULg) Estimation of the fascine efficiency in terms of runoff infiltration and sediments depositionDegré, Aurore ; Pineux, Nathalie ; Cantreul, Vincent et alin Geophysical Research Abstracts (2013), 15Runoff inundations and mudflows are more and more frequent phenomena. In 2011, Belgium had a lot of its municipalities affected by this problematic. Since then, mitigation measures are more and more set ... [more ▼]Runoff inundations and mudflows are more and more frequent phenomena. In 2011, Belgium had a lot of its municipalities affected by this problematic. Since then, mitigation measures are more and more set up in agricultural watersheds. The fascines are one of these measures which allow to protect the public and private infrastructures and in the same way, which don’t reduce the famers productivity. They consist in branches faggots piled up between two rows of stakes. These linear constructions are mainly put in place across concentrated runoff axis in order to slow down the water and to filter the mud. Only few quantifications of their effectiveness (in terms of flow and concentration water reduction) exist and are however needed to better recommend these types of mitigation measures. Our experiment aims at measuring discharge and mud concentration reduction due to the fascines in a completely defined context. The tests were realised through fascines planted in field border. A watertight surface of 2,45m to 0,80m carries the water to the fascines. Three types of fascines were tested (willow wood fascine, straw fascine, straw compacted fascine), three different water flows were applied (0,5L/s, 3L/s and 6L/s) and three water concentration in dry soil (13g/L, 26g/L, 38g/L) were used. The different factor combinations were tested. The results show that we can expect a reduction of 60% of the flow for the biggest water flows (proportional efficiency with the water flow). The factor interaction study doesn’t allow to see a difference between the type. About the sediment water concentration, the filtration can reach 50%, the fascine with wood faggots showing a better efficiency. Finally, the difference between the fascine type show that straw fascine can support a biggest watershed (25 hectares) than the wood faggot fascine can (5-10 hectares) but during a smaller return period (one year against five years). [less ▲]Detailed reference viewed: 27 (7 ULg) Physico-chemical and membrane-interacting properties of D-xylose-based bolaforms. Influence of the anomeric configurationNasir, Mehmet Nail ; Legrand, Vincent; Gatard, Sylvain et alin MATEC Web of Conferences (2013), ACCEPTEDSugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the ... [more ▼]Sugar-based biosurfactants such as xylose-derived bolaforms have interesting properties, for example high biocompatibility and biodegradability which make them potential useful molecules in the pharmaceutical and cosmetic fields. Until now, no detailed analyses of the physico-chemical properties of these compounds have been undertaken. Two symmetrical D-xylose-based bolaforms were chemically synthesized where the two xylose heads are linked via an acetal link to a hydrocarbon chain containing 18 carbon atoms and an unsaturation. The two bolaforms differ only by their anomeric configuration: or The bolaform exhibits interfacial properties at the air-water interface which is not the case for the . FTIR spectroscopy showed that the interactions between the bolaform and POPC, a model phospholipid, involve the carbonyl groups of the phospholipid [less ▲]Detailed reference viewed: 30 (16 ULg) Milk components predicted by mid-infrared spectrometry as indicators of the udder health status of the dairy cowBastin, Catherine ; Laine, Aurélie ; Gengler, Nicolas in Journal of Dairy Science (2013), 96(E-Suppl. 1), Detailed reference viewed: 22 (5 ULg) Gestion de la reproduction dans les troupeaux bovins laitierHanzen, Christian ; Rao, Anne-Sophie ; Theron, Léonard in Revue Africaine de Santé et de Productions Animales [=RASPA] (2013)La décision de la commission européenne de mettre fin en 2015 à la politique des quotas laitiers mise en place en 1984 va vraisemblablement bousculer le paysage laitier européen mais aussi mondial. Plus ... [more ▼]La décision de la commission européenne de mettre fin en 2015 à la politique des quotas laitiers mise en place en 1984 va vraisemblablement bousculer le paysage laitier européen mais aussi mondial. Plus que jamais les grands pays producteurs (Etats-Unis, Canada, France, Allemagne, Pays-Bas, Irlande, Nouvelle-Zélande) vont dans ce contexte de libéralisation et de globalisation de « l’or blanc » se livrer une concurrence effrénée dans laquelle la majorité des producteurs n’auront que peu ou rien à dire. L’augmentation attendue de la production laitière mondiale (15 milliards de litres par an entre 2010 et 2020) résulte bien entendu de l’augmentation de la population mondiale (3,1 milliards entre 1970 et 2010 auxquels s’ajouteront 2 milliards de plus en 2050) mais également du fait que davantage de personnes en Extrême et Moyen-Orient, en Amérique du Sud et en Afrique du Nord consomment davantage de lait et de produits dérivés. L’enjeu pour la majorité des éleveurs européens ou non va être de réduire les coûts liés à la production laitière en (1) optimisant les ressources alimentaires, (2) en améliorant la santé mammaire, (3) en augmentant la longévité des vaches, (4) en réduisant la fréquence des maladies métaboliques, locomotrices ou infectieuses et (5) en améliorant la fécondité. L’amélioration de la fécondité passe définition oblige par la réduction de l’âge du premier vêlage et de l’intervalle entre vêlages. Par gestion, il faut entendre dans un premier temps la quantification du problème et dans un second l’identification des diverses hypothèses diagnostiques qui en sont responsables. Les facteurs de nature alimentaire, thérapeutique, pathologique ou de gestion susceptibles de modifier l'évolution normale de chaque femelle depuis sa naissance jusqu'au moment de sa réforme sont de nature diverse. Ils concernent l'individu ou le troupeau. Ils sont directement ou indirectement responsables de leur fertilité et/ou de leur fécondité. Leurs effets se manifestent de manière isolée ou synergique. Ils concernent aussi bien les animaux que ceux qui en ont la responsabilité sanitaire ou de gestion. Ils sont de nature anatomique, infectieuse, hormonale, thérapeutique ou zootechnique. Par gestion de la reproduction, il faut entendre une approche épidémiologique, globale de l’infécondité qui en intègre les aspects spécifiques sans négliger pour autant les autres aspects qui ne lui sont pas directement liés. Par gestion de la reproduction, on peut aussi comprendre sa gestion hormonale à savoir le recours à des protocoles thérapeutiques de synchronisation des inséminations et donc des vêlages. L’une et l’autre approche s’inscrive dans le contexte d’une identification systématique des animaux à risque au travers d’un suivi mensuel de reproduction. Ce suivi est la clé de voûte d’une gestion de la reproduction. Au travers d’une démarche hypothético-déductive, la présente communication se propose de - quantifier les performances de reproduction au travers des ses principaux paramètres de fécondité et de fertilité : cette première étape est indispensable pour identifier la présence ou non d’un problème d’infécondité, - passer en revue et de manière aussi synthétique que possible les diverses hypothèses et donc les facteurs de risque responsables d’infécondité - proposer des stratégies curatives ou préventives, anti-infectieuses ou hormonales voire zootechniques pour limiter les conséquences de l’infécondité. [less ▲]Detailed reference viewed: 67 (7 ULg) Strontium ranelate prevents radiological progression in patients with primary knee osteoarthritisCooper, C; Berembaum, F; Nash, P et alin Osteoporosis International (2013), 24(1), 306-307Detailed reference viewed: 10 (2 ULg) Potential of mid-infrared spectrum of milk to detect changes in the physiological status of dairy cowsLaine, Aurélie ; Goubau, Amaury; Hammami, Hedi et alin Journal of Dairy Science (2013)Detailed reference viewed: 19 (11 ULg) Visean corals from the transverse Jebel Begaa to Gara el Itima (eastern Tafilalt, Morocco)Aretz, Markus; Denayer, Julien in Document de l'Institut Scientifique, Rabat (2013), 26Detailed reference viewed: 14 (1 ULg) The Immunomodulating Peptide Thymosin Alpha 1 Has no Effect on Multiple Myeloma Evolution and on Immune ReconstitutionBinsfeld, Marilène ; Otjacques, Eléonore ; Hannon, Muriel et alin Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 41Detailed reference viewed: 10 (4 ULg) ALERT protocol: Efficiency of an e-learning training in a non-Advanced Medical Priority Dispatch System (AMPDS) Emergency Medical Services centresSTIPULANTE, Samuel ; HANSENNE, Yannick; EL-FASSI, Mehdi et alin Resuscitation (2013)Detailed reference viewed: 14 (1 ULg) Symmetries in multi-Higgs-doublet modelsIvanov, Igor ; Vdovin, Evgenyin AIP Conference Proceedings (2013)We report the recent progress in understanding of symmetries which can be implemented in the scalar sector of electroweak symmetry breaking models with several Higgs doublets. In particular we present the ... [more ▼]We report the recent progress in understanding of symmetries which can be implemented in the scalar sector of electroweak symmetry breaking models with several Higgs doublets. In particular we present the list of finite reparametrization symmetry groups which can appear in the three-Higgs-doublet models. [less ▲]Detailed reference viewed: 14 (1 ULg) Self-shuffling wordsCharlier, Emilie ; Kamae, Teturo; Puzynina, Svetlana et alin Lecture Notes in Computer Science (2013)In this paper we introduce and study a new property of infinite words which is invariant under the action of a morphism: We say an infinite word x, defined over a finite alphabet A, is self-shuffling if x ... [more ▼]In this paper we introduce and study a new property of infinite words which is invariant under the action of a morphism: We say an infinite word x, defined over a finite alphabet A, is self-shuffling if x admits factorizations: x=\prod_{i=1}^\infty U_iV_i=\prod_{i=1}^\infty U_i=\prod_{i=1}^\infty V_i with U_i,V_i \in \A^+. In other words, there exists a shuffle of x with itself which reproduces x. The morphic image of any self-shuffling word is again self-shuffling. We prove that many important and well studied words are self-shuffling: This includes the Thue-Morse word and all Sturmian words (except those of the form aC where a is a letter and C is a characteristic Sturmian word). We further establish a number of necessary conditions for a word to be self-shuffling, and show that certain other important words (including the paper-folding word and infinite Lyndon words) are not self-shuffling. In addition to its morphic invariance, which can be used to show that one word is not the morphic image of another, this new notion has other unexpected applications: For instance, as a consequence of our characterization of self-shuffling Sturmian words, we recover a number theoretic result, originally due to Yasutomi, which characterizes pure morphic Sturmian words in the orbit of the characteristic. [less ▲]Detailed reference viewed: 18 (1 ULg) A new method for computing the derivatives of the mean and amplitude of physiological variables with respect to the parameters of a cardiovascular system modelPironet, Antoine ; Dauby, Pierre ; Revie, James A. et alin Minimally Invasive Therapy & Allied technologies : Official Journal of the Society for Minimally Invasive Therapy (2013), 22Detailed reference viewed: 17 (6 ULg) Mise en image du spectacle et spectacularisation de l’image à l’âge baroqueDelfosse, Annick ; Dekoninck, Ralph; Delbeke, Maarten et alin Degrés : Revue de Synthèses à Orientation Sémiologique (2013)Detailed reference viewed: 58 (3 ULg) Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations in PER3 polymorphism under sleep deprivationMuto, Vincenzo ; Meyer, Christelle ; Jaspar, Mathieu et alin Sleep (2013), 36Detailed reference viewed: 53 (12 ULg) Chirurgie bariatrique chez le patient diabétique de type 1 : résultats d’une expérience limitée.FRANCK, Marie ; DE FLINES, Jenny ; PAQUOT, Nicolas et alin Diabète & Métabolisme (2013), 39(suppl), 102Detailed reference viewed: 7 (1 ULg) Importance of LUC and ILUC on the carbon footprint of bioproduct:case of bio-HDPEBelboom, Sandra ; Léonard, Angélique in International seminar on society and materials (2013)Due to the depletion of fossil fuels and the increase of greenhouse gas emissions, solutions are needed to replace petrol based products. As a consequence, the number of biobased products developed using ... [more ▼]Due to the depletion of fossil fuels and the increase of greenhouse gas emissions, solutions are needed to replace petrol based products. As a consequence, the number of biobased products developed using agricultural feedstock is continuously increasing. This study focuses on the carbon footprint of bio-HDPE produced either from Brazilian sugar cane or Belgian sugar beet. The goal of this study is to compare the carbon footprint of bio-HDPE with the fossil one, taking into account the effect of land use change. Common boundaries of the agricultural systems comprise the cultivation step for both crops, i.e. sugar cane and sugar beet, with all associated energy and fertilizer consumptions, the transportation step from field to the industrial plant, the sugar crops transformation into hydrate bioethanol, the by-products valorisation, the dehydration and polymerization steps and the HDPE incineration as end of life issue. Fossil scenario includes the production of ethylene, its polymerization and its incineration. When comparing the entire life cycle of bio and fossil HDPE, the GHG emissions are lower for the biobased product which is the willing effect. This result is only valid if no Land Use Change (LUC) or Indirect Land Use Change (ILUC) effect appears. To assess the environmental impact of the deforestation or of the transformation of a pasture into a field, the EC-Guidelines from the European Union were used in order to calculate the CO2 emissions depending on several parameters. For sugar cane, LUC consists in the transformation of pastures into fields in the region of Sao Paulo in Brazil. Three scenarios can be developed based on different agricultural practices for pasture and field (tillage and fertilizers inputs): the best, the worst and the average. The best case leads to a supplementary environmental gain. The worst and average achieve additional emissions. A payback time, considering the time needed to find again an environmental gain compared to the fossil counterpart, was calculated for the average scenario which is equal to 12 years. The ILUC effect for sugar cane is assumed to be deforestation due to the transformation of forest into pasture induced by the previous LUC effect. The rate of deforestation can vary between 16% or 100% depending on used statistics and leads to a payback time of respectively 26 and 101 years. For sugar beet, no LUC is considered. Indeed, no land expansion is available in Belgium due to small available areas. In the case of an increase of bioplastics production, Belgium should import sugar beet from neighboring countries which can induce ILUC. In this study, sugar beet is assumed to be provided by the Netherlands on pastures previously transformed into fields. The average scenario implies a payback time of 8 years. This study permits to highlight the importance of LUC and ILUC especially for energetic crops dedicated to replace fossil products. This effect can reverse expected results and induce long payback times. [less ▲]Detailed reference viewed: 70 (2 ULg) Strontium ranelate effect on knee osteoarthritis progression : a MRI analysisGenant, HK; Zaim, S; Guermazi, A et alin Osteoporosis International (2013), 24(1), 312-313Detailed reference viewed: 15 (2 ULg) AMELIORATION DE L’HUMEUR ET DE L’ANXIETE SOUS OCYTOCINE DANS LA DEPRESSION: ETUDE PILOTEScantamburlo, Gabrielle ; ANSSEAU, Marc ; Geenen, Vincent et alin Encéphale (L') (2013)Detailed reference viewed: 14 (0 ULg) The general approach to the patient with osteoarthritis : is a treatment algorithm feasible ?Reginster, Jean-Yves in Osteoporosis International (2013), 24(1), 385Detailed reference viewed: 6 (2 ULg) Influence of lignin in Reticulitermes santonensis: symbiotic interations investigated through proteomicsBauwens, Julien ; Tarayre, Cédric ; Brasseur, Catherine et alin Symbiosis (2013)The gut of lower termites is populated by numerous microbial species belonging to prokaryotes, fungi, yeasts and protists. These micro-organisms are organized in a complex symbiotic system, interacting ... [more ▼]The gut of lower termites is populated by numerous microbial species belonging to prokaryotes, fungi, yeasts and protists. These micro-organisms are organized in a complex symbiotic system, interacting together and with the insect host. Their likely ability to degrade ligno-cellulosic compounds could lead to improvements in second generation biofuels production. Lignin elimination represents a critical point as this polymer significantly interferes with industrial process of cellulose. Although host produces its own lignin-degrading enzymes, some symbionts may participate in digestion of lignin and its degradation products in termite gut. Here, we compared gut proteomes from R. santonensis after rearing on artificial diets composed of cellulose with and without lignin. The effect of lignin in artificial diets on different parts of the digestive tract was compared through liquid chromatography associated with tandem mass spectrometry (LC-MS/MS) experiments. Enzymatic assays were performed to characterize activities present in R. santonensis digestive tract after feeding on artificial diets. Microscopic observations of microbial communities provided some information on population balances after feeding experiment. [less ▲]Detailed reference viewed: 50 (27 ULg) Pharmacological management : osteoporosis and osteoarthritis, similarities and differencesReginster, Jean-Yves in Osteoporosis International (2013), 24(1), 75-76Detailed reference viewed: 2 (2 ULg) Another Generalization of Abelian Equivalence: Binomial Complexity of Infinite WordsRigo, Michel ; Salimov, Pavel in Lecture Notes in Computer Science (2013), 8079The binomial coefficient of two words u and v is the number of times v occurs as a subsequence of u. Based on this classical notion, we introduce the m-binomial equivalence of two words refining the ... [more ▼]The binomial coefficient of two words u and v is the number of times v occurs as a subsequence of u. Based on this classical notion, we introduce the m-binomial equivalence of two words refining the abelian equivalence. The m-binomial complexity of an infinite word x maps an integer n to the number of m-binomial equivalence classes of factors of length n occurring in x. We study the first properties of m-binomial equivalence. We compute the m-binomial complexity of the Sturmian words and of the Thue-Morse word. We also mention the possible avoidance of 2-binomial squares. [less ▲]Detailed reference viewed: 31 (9 ULg) How adaptation strategies of crops could counteract climate change effects? The case of four catchments in Wallonia, Belgium.Bauwens, Alexandra ; Sohier, Catherine ; Degré, Aurore in Geophysical Research Abstracts (2013), 15A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to signiﬁcantly reduce crops’ yields under current agricultural practices ... [more ▼]A sharp increase in extreme heat and drought stress is projected in Belgium by the end of the 21st century, with the potential to signiﬁcantly reduce crops’ yields under current agricultural practices. This contribution uses an agro-hydrological model in order to assess the potential effects of climate evolution on crop development, yield, and water balance for the main agricultural productions in the Meuse catchment. Erosion risk is also evaluated. We show that grasslands and maize yield decrease and yield variability increases under climate change scenarios. The leaf area index study permits to put in emphasis the earlier start of the vegetation due to warmer climate. It appears that all the sensitive stages occur earlier in the season and that crops are negatively affected by summer drought stress. The better understanding of crops development under evolving climate allows us to propose some changes in agricultural practices and to assess their effectiveness. We evaluate different strategies of adaptation in agricultural practices in order to reduce the potential negative effects of climate change on grasslands and maize production. Adaptation strategies proposed are advanced sowing and harvesting date, introduction of a cover crop for maize and advance in the cutting dates for grasslands. In the particular case of the Vesdre catchment, shifting the growth period of maize permits to avoid the water-deﬁcit period and allow increased yield. This shift makes it possible to introduce a cover crop that will drastically reduce winter soil erosion. For grassland, the adjustment of the cutting dates favored the ﬁrst cut and the earlier start of the vegetation. The second cut is less proﬁtable due to summer drought stress. The vulnerability assessments focused on the main rotation encountered in the cultivated areas and in the difference in the cover type of these crops. [less ▲]Detailed reference viewed: 9 (3 ULg) Melanopsin bistability impinges on higher order cognitive brain functionChellappa, Sarah Laxhmi ; Ly, Julien ; Meyer, Christelle et alin Sleep (2013), 36(Suppl. 1), Detailed reference viewed: 16 (1 ULg) Patients' preferences for osteoporosis drug therapy : a discrete choice experimentHiligsmann, Mickaël ; Dellaert, B; Dirksen, C et alin Osteoporosis International (2013), 24(1), 53Detailed reference viewed: 7 (2 ULg) Initiation of methane turbulent flux measurements over a grazed grassland in BelgiumDumortier, Pierre ; Aubinet, Marc ; Chopin, Henri et alin Geophysical Research Abstracts (2013), 15Detailed reference viewed: 17 (8 ULg) Inhibition of sclerostin with romosozumab in postmenopausal women with low BMD : phase 2 trial resultsMcClung, M; Grauer, A; Boonen, S et alin Osteoporosis International (2013), 24(1), 38-39Detailed reference viewed: 46 (2 ULg) Processing of Ti alloys by additive manufacturing: a comparison of the microstructures obtained by laser cladding, selective laser melting and electron beam meltingReginster, Sylvie ; Mertens, Anne ; Paydas, Hakan et alin Materials Science Forum (2013), 765Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the ... [more ▼]Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the restoration - of complex and (almost) fully dense parts from Ti alloys. Both techniques involve the melting of a metallic powder with a laser. In the SLM process, the metallic powder is deposited layer by layer in a powder bed and then molten locally according to the desired shape, whereas in LC, the metallic powder is directly projected onto a substrate through a nozzle coaxial with the laser beam. The present research aims at comparing Ti-6Al-4V samples processed by these two techniques with reference samples produced by electron beam melting (EBM), another well established additive manufacturing process (patented by Arcam AB Company) in which a powder bed is molten locally by means of an electron beam. In all three processes, the melt pool undergoes an ultrafast cooling and solidifies very rapidly once the beam has left the area, thus giving rise to strongly out-of-equilibrium microstructures. Yet, each one of these processes also has its own specificities e.g. in terms of scanning strategy and of working atmosphere (low vacuum vs. protective Ar flow). In the present work, the microstructures obtained by these three processes have been compared in details, with a particular attention for characteristics such as porosity, grain size, and the various phases present. Since epitaxial growth of the newly deposited layer on the material previously solidified has been shown [1, 2] to exert a strong influence on the microstructure and on the resulting mechanical properties, great care has been taken to study the microstructural anisotropy associated with each one of the three processes. [less ▲]Detailed reference viewed: 230 (53 ULg) Nutrition and bone health : turning beliefs into knowledge for healthy behaviourBrandi, ML; Reginster, Jean-Yves in Osteoporosis International (2013), 24(1), 388-389Detailed reference viewed: 18 (2 ULg) Preliminary data on plicathyridines (Brachiopoda) from the Frasnian of southern Belgium and the Middle East (Afghanistan, Iran)Mottequin, Bernard ; Marion, Jean-Marc ; Brice, Denisein Documents scientifiques de l'Institut de Rabat (2013), 26Detailed reference viewed: 12 (5 ULg) On the Number of Abelian Bordered WordsRampersad, Narad; Rigo, Michel ; Salimov, Pavel in Lecture Notes in Computer Science (2013), 7907In the literature, many bijections between (labeled) Motzkin paths and various other combinatorial objects are studied. We consider abelian (un)bordered words and show the connection with irreducible ... [more ▼]In the literature, many bijections between (labeled) Motzkin paths and various other combinatorial objects are studied. We consider abelian (un)bordered words and show the connection with irreducible symmetric Motzkin paths and paths in Z not returning to the origin. This study can be extended to abelian unbordered words over an arbitrary alphabet and we derive expressions to compute the number of these words. In particular, over a 3-letter alphabet, the connection with paths in the triangular lattice is made. Finally, we study the lengths of the abelian unbordered factors occurring in the Thue--Morse word. [less ▲]Detailed reference viewed: 39 (10 ULg) First steps towards an explicit modeling of aba production and translocation in relation with the water uptake dynamicsLobet, Guillaume ; Pagès, Loic; Draye, Xavierin Acta Horticulturae (2013), 991Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act ... [more ▼]Water flow in the plant continuum is thought to be controlled by the leaf, xylem and the root radial conductances. Leaf conductance is widely recognized as the master control in the system as it can act as a switch in the water flow, even under high transpiration demand. The control of the stomatal aperture by the plant has been the object of numerous research projects since decades and different models have been developed to study stomatal regulation. The plant hormone abscisic acid (ABA) produced in the leaves acts as an endogenous signal triggering stomatal closure, but is also thought to act as a long distance signal that is produced by roots experiencing water deficit. However, the relative contributions of leaf-supplied ABA, root-supplied ABA and xylem water potential in the regulation of water flow remains a matter of controversy. Using a novel functional structural plant model (PlaNet-Maize-ABA), we report here a first attempt to explicitly simulate ABA production, degradation, translocation in all plant organs and their effect on the transpiration flow. [less ▲]Detailed reference viewed: 11 (2 ULg) Genetic analysis of pig survival in a crossbred populationDufrasne, Marie ; Misztal, Ignacy; Tsuruta, Shogo et alin Journal of Animal Science (2013), 91(E-Suppl.2), 193Detailed reference viewed: 24 (11 ULg) Interaction of fengycin with stratum corneum mimicking model membranes: a calorimetry studyNasir, Mehmet Nail ; Eeman, Marc; Olofsson, Gerd et alin European Biophysics Journal [=EBJ] (2013), 42(S1), 168Detailed reference viewed: 10 (2 ULg) Genetic analysis of longitudinal measurements of feed intake in Piétrain sire linesDufrasne, Marie ; Jaspart, Véronique; Wavreille, José et alin Journal of Animal Science (2013), 91(E-Suppl.2), 293Detailed reference viewed: 27 (8 ULg) Indirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic womenReginster, Jean-Yves ; Ellis, AG; Luo, X et alin Osteoporosis International (2013), 24(1), 37Detailed reference viewed: 13 (5 ULg) Spectral Modelling of Massive Binary Systems: The Example of LZ CepPalate, Matthieu ; Rauw, Grégor ; Mahy, Laurent in Central European astrophysical bulletin (2013)Despite their importance for many astrophysical processes, massive stars are still not fully understood. Massive binaries offer an attractive way to improve our knowledge of the fundamental properties of ... [more ▼]Despite their importance for many astrophysical processes, massive stars are still not fully understood. Massive binaries offer an attractive way to improve our knowledge of the fundamental properties of these objects. However, some secondary effects are known to generate variations in the spectra of massive binaries, rendering their analyses more difficult. We present here a new approach to the computation of synthetic spectra of massive binaries at different phases of their orbital cycle. Our model starts with the Roche potential modified by radiation pressure and accounts for the influence of the companion star on the shape and physical properties of the stellar surface. We further account for gravity darkening and reflection effects to compute the surface temperature. Once the local gravity and temperature are determined, we interpolate in a grid of NLTE plan-parallel atmosphere model spectra to obtain the local contribution to the spectrum at each surface points. Then we sum all the contributions, accounting for the Doppler shift, and limb-darkening to obtain the total spectrum. The computation is repeated for different orbital phases and can be compared to the observations to determine the best parameters. We illustrate our method through the example of the LZ Cep system (O9III + ON9.7V). [less ▲]Detailed reference viewed: 12 (4 ULg) Hypovitaminosis D and osteoporosis in burn patients: are the current practices enough ?ROUSSEAU, Anne-Françoise ; LEDOUX, Didier ; DAMAS, Pierre et alin Osteoporosis International (2013), 24(Suppl 1), 377Detailed reference viewed: 31 (12 ULg) Mobile phones video CPR: preliminary results in a non-Advanced Medical Priority Dispatch System (AMPDS) Emergency Medical Services centresSTIPULANTE, Samuel ; DELFOSSE, Anne-sophie ; ZANDONA, Régine et alin Resuscitation (2013)Detailed reference viewed: 15 (5 ULg) Le ranélate de strontium diminue la proportion de patients progressant rapidement dès la première année : une analyse post hoc de l'étude SEKOIAChevalier, X; Richette, P; Bruyère, Olivier et alin Revue du Rhumatisme (2013), 80(S1), 59-60Detailed reference viewed: 10 (1 ULg) Probing the phase of the elastic $pp$ scattering amplitude with vortex proton beamsIvanov, Igor in AIP Conference Proceedings (2013)We show that colliding vortex proton beams instead of (approximate) plane waves can lead to a direct measurement of how the overall phase of the scattering amplitude changes with the scattering angle. In ... [more ▼]We show that colliding vortex proton beams instead of (approximate) plane waves can lead to a direct measurement of how the overall phase of the scattering amplitude changes with the scattering angle. In elastic $pp$ scattering, this will open a novel way to measure the parameter $\rho(t)$ and probe the real part of the Pomeron. [less ▲]Detailed reference viewed: 9 (1 ULg) What are the clinical characteristics of patients improving their gait and body balance with whole body vibration ? Results of a 3-month randomized controlled trialBeaudart, Charlotte ; Buckinx, Fanny ; Maquet, Didier et alin European Geriatric Medicine (2013), 4(S1), 53Detailed reference viewed: 16 (5 ULg) Spatial distribution of erosion and deposition on an agricultural watershedPineux, Nathalie ; Colinet, Gilles ; Degré, Aurore in Geophysical Research Abstracts (2013), 15To better understand the agricultural landscapes evolution becomes an essential preoccupation and, for this, it is needed to take into account the sediments deposition, in a distributed way. As it is not ... [more ▼]To better understand the agricultural landscapes evolution becomes an essential preoccupation and, for this, it is needed to take into account the sediments deposition, in a distributed way. As it is not possible in practice to study all terrestrial surfaces in detail by instrumenting sectors to obtain data, models of prediction are valuable tools to control the current problems, to predict the future tendencies and to provide a scientific base to the political decisions. In our case, a landscape evolution model is needed, which aims at representing both erosion and sedimentation and dynamically adjusts the landscape to erosion and deposition by modifying the initial digital elevation model. The Landsoil model (Landscape design for Soil conservation under soil use and climate change), among others, could fulfil this objective. It has the advantage to take the soil variability into account. This model, designed for the analysis of agricultural landscape, is suitable for simulations from parcel to catchment scale, is spatially distributed and event-based. Observed quantitative data are essential (notably to calibrate the model) but still limited. Particularly, we lack observations spatially distributed on the watershed. For this purpose, we choose a watershed in Belgium (Wallonia) which is a 124 ha agricultural zone in the loamy region. Its slopes range from 0% to 9%. To test the predictions of the model, comparisons will be done with: - sediment measurements which are done with water samplings in four points on the site to compare the net erosion results; - sediment selective measurements (depth variation observed along graduated bares placed on site) to compare the erosion and deposition results; - very accurate DSM’s (6,76 cm pixel resolution X-Y) obtained by the drone (Gatewing X100) each winter. Besides planning what the landscape evolution should be, a revision of the soil map (drew in 1958) is organized to compare with the past situation and establish how the landscape moved in 50 years. The first results of the sediment measurements and of the pictures of the drone will be showed in the presentation. [less ▲]Detailed reference viewed: 22 (5 ULg)