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See detailAnalyse qualitative d’un dispositif didactique visant à impliquer des élèves de primaire dans l’expression de leur besoin de mouvement
Cloes, Stéphanie; Cloes, Marc ULg

in Science & Sports (2014, October), 29(Hors-série 1), 25

Être capable de ressentir un mouvement et de l'exprimer est l'une des compétences qu'ils devraient avoir acquises à l'issue de l'enseignement fondamental. Il semble donc opportun de développer des ... [more ▼]

Être capable de ressentir un mouvement et de l'exprimer est l'une des compétences qu'ils devraient avoir acquises à l'issue de l'enseignement fondamental. Il semble donc opportun de développer des procédés susceptibles d'être exploités en classe. [less ▲]

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See detailOrthotopic liver transplantation for hepatocellular car- cinoma after successful downstaging: results from the Belgian multicentre cohort
Schreiber, J.; Lerut, J; Verslype, C et al

in Hepatology (Baltimore, Md.) (2014, October), 60(S1), 468550

Purpose: Successful downstaging of hepatocellular carcinoma (HCC) into the Milan criteria (MC) remains a controversial indication for orthotopic liver transplantation (OLT). In Belgium, successful ... [more ▼]

Purpose: Successful downstaging of hepatocellular carcinoma (HCC) into the Milan criteria (MC) remains a controversial indication for orthotopic liver transplantation (OLT). In Belgium, successful downstaging of HCC is an accepted non-standard- ized exception (NSE) for liver allocation. This NSE group rep- resents a unique cohort to analyse if OLT can be safely offered to patients with those extended allocation criteria. The aim of this study is to compare the overall and recurrence free survival after cadaveric OLT between patients with successful downstaging (MILDOWN) and patients always inside the MC (MILIN) from all Belgian transplant centres. Methods: We ret- rospectively analysed all patients listed for OLT with HCC and underlying cirrhosis between 12/2006 and 12/2011 from all Belgian liver transplant centres. Successful downstaging was defined as bringing a patient who was outside the MC into the MC after locoregional therapy (LRT). Results: Overall 381 patients were listed in Belgium during the study period. Of these, 320 received OLT. 248 were MILIN, 62 were MIL- DOWN and 10 were transplanted outside MC. Downstaging treatment included transarterial chemoembolization (TACE; n=26), radiofrequency (RF; n=9), transarterial radioembolisa- tion (TARE; n=4), resection (n=3), percutaneous ethanol injec- tion (n=2) and a combination of the above-mentioned therapies in 18 cases. In the MILIN group 67.3% received locoregional therapy before transplantation, with no significant differences in the distribution of treatment type compared to the MIL- DOWN group. At listing there were no significant differences between the MILIN and MILDOWN group for age, gender and underlying liver disease. Median time on waiting list between the two groups was similar (120 days vs. 115.5 days). Overall survival at 1 year was not significantly different between MILIN and MILDOWN (87.1% vs. 79%; p=0.120). 1.6% of patients were lost to follow-up in both groups. Although not significant, recurrence free survival at 1 year tended to be higher in the MILIN group than in the MILDOWN group (83.9% vs. 74.2%; p=0.073). Conclusion: In this large Belgian multicentre cohort, overall and recurrence free survival at 1 year are not signifi- cantly different between patients who have been downstaged successfully and patients who were always inside the Milan criteria. However, a longer follow up period will define, if the trend of lower survival in the successfully downstaged group becomes significant. Factors associated with HCC recurrence have to be identified. [less ▲]

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See detailAnalyse de l'efficacité de l'accoutumance à l'eau chez l'enfant préscolaire
Mornard, Manhattan ULg; Deflandre, Dorian ULg; Delvaux, Anne ULg et al

in Science et sports (2014, October), 29(Hors-série 1), 13

L'accoutumance à l'eau apparaît comme un prérequis indispensable à l'apprentissage des techniques de nage. Après différents tests chez des enfants en bas âge, l'étude confirme l'efficacité à l ... [more ▼]

L'accoutumance à l'eau apparaît comme un prérequis indispensable à l'apprentissage des techniques de nage. Après différents tests chez des enfants en bas âge, l'étude confirme l'efficacité à l'accoutumance à l'eau. [less ▲]

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See detailAnalyse du comportement et des attitudes d'enfants de primaire impliqués dans des pauses d'activité physique scolaires (PAPS). Etude de cas.
Cloes, Stéphanie; Cloes, Anne-Marie; Cloes, Marc ULg

in Science & Sports (2014, October), 29(Hors-série 1), 26

Malgré que l'activité physique à l'école est identifiée comme un facteur favorable à la réussite scolaire, la réalité de terrain montre que les instituteurs présentent pourtant des réticences à planifier ... [more ▼]

Malgré que l'activité physique à l'école est identifiée comme un facteur favorable à la réussite scolaire, la réalité de terrain montre que les instituteurs présentent pourtant des réticences à planifier des pauses mouvement pendant leurs activités. Dans cette étude, nous avons mis en place des pauses d'activité physique scolaire et avons analysés les comportement et attitudes des élèves concernés. [less ▲]

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See detailMise en place d'un Kid's Athletics pour les enfants de 5 à 8 ans: avis des parents, avis des entraîneurs et analyse critique
Wuillaume, Sandrine; Delcros, Vincent; Jidovtseff, Boris ULg

in Science et sports (2014, October), 27(Hors-série 1), 32-33

En Belgique, les compétitions proposées aux enfants de moins de 10 ans sont des modèles réduits des compétitions d'adultes. Face au constat de retard, la Ligue Francophone Belge d'Athlétisme a mis sur ... [more ▼]

En Belgique, les compétitions proposées aux enfants de moins de 10 ans sont des modèles réduits des compétitions d'adultes. Face au constat de retard, la Ligue Francophone Belge d'Athlétisme a mis sur pied un groupe de réflexion qui a décidé d'organiser une première compétition Kid's Athletics. [less ▲]

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See detailLe jardin d'accoutumance à l'eau CEReKI: une solution pour toutes les piscines
Delvaux, Anne ULg; Mornard, Manhattan ULg; Vandermeulen, Mary et al

in Science et sports (2014, October), 29(Hors-série 1), 12

La plupart des piscines publiques ont une petite profondeur de 80 cm et ne sont donc pas adaptées aux très jeunes enfants. Le CEReKI a mis en place un jardin d'accoutumance à l'eau afin que chaque enfant ... [more ▼]

La plupart des piscines publiques ont une petite profondeur de 80 cm et ne sont donc pas adaptées aux très jeunes enfants. Le CEReKI a mis en place un jardin d'accoutumance à l'eau afin que chaque enfant puisse s'accoutumer à l'eau "sans avoir spécialement pied". [less ▲]

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See detailHCVerso2: a phase III study of faldaprevir plus deleobuvir and ribavirin for chronic HCV genotype 1b infection in treatment naïve patients including those ineligible for pegylated interferon
Nelson, D; Andreone, P; Colombo, M et al

in Hepatology (Baltimore, Md.) (2014, October), 60(S1),

In treatment-naïve, non-cirrhotic patients with HCV GT1b infection, faldaprevir + deleobuvir + ribavirin for 16 or 24 w resulted in comparable SVR 12 rates (76% vs 82%) with similar tolerability profiles ... [more ▼]

In treatment-naïve, non-cirrhotic patients with HCV GT1b infection, faldaprevir + deleobuvir + ribavirin for 16 or 24 w resulted in comparable SVR 12 rates (76% vs 82%) with similar tolerability profiles. Patients with cirrhosis achieved SVR 12 of 74% (24w). The adjusted SVR rates for 16 or 24w in patients with or without cirrhosis were significantly higher than historical control. [less ▲]

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See detailNumerical investigation of cut-edge effect using the Gurson-Tvergaard-Needleman model
Lemoine, Xavier; Tudor, Balan; Habraken, Anne ULg

in Procedia Engineering (2014, October)

In this contribution, the formability of sheet metal cut edges is investigated using damage model.Classical forming limit diagrams are known not to apply properly to the cut edges. However, with mild ... [more ▼]

In this contribution, the formability of sheet metal cut edges is investigated using damage model.Classical forming limit diagrams are known not to apply properly to the cut edges. However, with mild steels the sheet edges usually behave better than the Forming Limit Diagram prédictions, so this phenomenon has not been given sufficient attention. In contrast, for Advanced High Strengh Steels the cut edges exhibit reduced formability as compared to the plain sheet;this effect is very sensitive to the quality of the cutting process. The current investigation is aimed to evaluate the ability of available damage models to predict this effect on sample applications. The Gurson-Tvergaard-Needleman model is used and the material parameters for a Dual Phase are considered [1]. The effect of the cutting process is described by means of initial fields of equivalent plastic strain and porosity. The geometrical distribution and typical values for these two initial fields are devised based on literature . Numerical simulations of flat notched tensile tests are used within the FE code Abaqus/Explicit to illustrate the impact of the initial fields on the moment and the location of the failure initiation. The influence of the mesh size in the cutting-affected area is also investigated. The hole expansion test and a flat bending test are further simulated to investigate the influence of the cut edge. [less ▲]

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See detailPerception de la pharmacovigilance par les futurs pharmaciens hospitaliers belges, français, québécois et suisses
Cerruti, L; Lebel, D; Van Hees, Thierry ULg et al

in Journal of Population Therapeutics and Clinical Pharmacology (2014, September 17), 21(2), 320

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See detailSleep homeostasis and the circadian timing system set the dynamics and excitability of neuronal ensembles
Vandewalle, Gilles ULg

in Journal of Sleep Research (2014, September 14), Suppl

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See detailGlucose use and lactate production by equine fresh semen in human and equine extender
Ponthier, Jérôme ULg; De Tullio, Pascal ULg; Parrilla-Hernandez, Sonia et al

in Reproduction in Domestic Animals (2014, September), 49(suppl 3), 13

This study shows that this human semen extender doesn’t support equine semen preservation. Sperm cells’ glucose consumption and lactate production seem to be negligible, as these parameters were not ... [more ▼]

This study shows that this human semen extender doesn’t support equine semen preservation. Sperm cells’ glucose consumption and lactate production seem to be negligible, as these parameters were not affected by sperm concentrations in our study. Our results suggest that spermatozoa are able to cleave complex carbohydrates as glucose concentration in INRA96 increased over time. [less ▲]

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See detailA case of true hermaphrodism in a horse
Parrilla-Hernadez, Sonia; de la Rebière de Pouyade, Geoffroy ULg; Grulke, Sigrid ULg et al

in Reproduction in Domestic Animals (2014, September), 49(suppl 3), 50

True hermaphroditism in horses, is a complex and poorly under- stood disorder of sexual development characterized by the presence of both male and female gonads as separate organs or in a combined ... [more ▼]

True hermaphroditism in horses, is a complex and poorly under- stood disorder of sexual development characterized by the presence of both male and female gonads as separate organs or in a combined structure called ovotestis. A 3-year-old Spanish nullipa- rous mare with a history of stallion behaviour and an abnormal reproductive exam was presented at the Equine Clinic of the University of Li ege. Externally, a small vulva with an enlarged clitoris was observed. Transrectal ultrasonography showed a thin (<1 cm) uterus, leading to a small heterogeneous structure in the normal place of the left ovary. No structure could be identified in the presumed location of the right ovary. Speculum exam was compatible with a vaginal agenesis, as the cervix opened craniad the urethral meatus. Oestradiol, progesterone and testosterone concen- trations were compatible with a stallion’s endocrinology. Gonads were laparoscopically found in the usual location of the ovaries in both flanks and excised. Histopathology of both gonads showed atrophic testicular tissue with hyperplastic Leydig cells. The left gonad also contained ovarian tissue with some scarce primordial follicles. Clitoral enlargement is the first symptom most commonly identified in animals with true hermaphroditism and can be explained by the production of testosterone by the gonads, however, the aetiology of the vaginal agenesis is unknown. True hermaph- roditism in horses is generally related to 64XX syndrome with or without SRY gene translocation (impending karyotyping analysis). After 5 days the mare was discharged from the clinic, and in absence of testosterone the stallion behaviour disappeared in a couple of months. [less ▲]

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See detailMeasurement uncertainty for persistent organic pollutants by isotope dilution mass spectrometry
Eppe, Gauthier ULg; Diletti, G; Fernandes, A et al

in Organohalogen Compounds (2014, September), 76

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See detailEpidémiologie de la lithiase urinaire en Province de Liège
GADISSEUR, Romy ULg; Castiglione, Vincent ULg; JOURET, François ULg et al

in Néphrologie & Thérapeutique (2014, September), 10(5), 270

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See detailBright light therapy in restless legs syndrome: a doubleblind, placebo-controlled study
Kilic-Huck, Ulker; Meyer, Christelle ULg; Ruppert, Elisabeth et al

in Journal of Sleep Research (2014, September), 23

Medications often partially alleviate the symptoms of RLS patients, emphasizing the need for finding alternative treatments. Recent studies reported an efficacy of bright light therapy (BLT) in Parkinson ... [more ▼]

Medications often partially alleviate the symptoms of RLS patients, emphasizing the need for finding alternative treatments. Recent studies reported an efficacy of bright light therapy (BLT) in Parkinson disease. RLS pathogenesis involves the dopaminergic system and light has been shown to influence the dopaminergic tone. Therefore, the objective of our study was to determine the therapeutic value of three weeks of BLT on RLS symptoms severity, sleep quality, daytime somnolence, circadian rhythms and mood. [less ▲]

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See detailPsychological processes mediating the link between depression severity and the level of behavioural activation: Assessment of a conceptual model
Wagener, Aurélie ULg; Baeyens, Céline; Blairy, Sylvie ULg

in Psychomed (2014, September), (1-2), 49

INTRODUCTION. Depression is a common psychopathology characterized by a decrease of the level of behavioural activation (BA) that is the level of engagement in activities. The relationship between ... [more ▼]

INTRODUCTION. Depression is a common psychopathology characterized by a decrease of the level of behavioural activation (BA) that is the level of engagement in activities. The relationship between depression and BA is well-established in the scientific literature. According to theoretical models of depression, psychopathology is also characterized by biases in five sets of psychological processes (PP): self-image (e.g. self-esteem), negative repetitive thoughts (e.g. ruminative thoughts), experiential avoidance (e.g. mindfulness), environmental satisfaction (e.g. environmental reward observation) and emotional regulation (e.g. distress tolerance). Therefore, the present study aims to identify PP mediating the relationship between depression and the level of BA. In order to reach this objective, a conceptual model is tested. METHOD. 361 adults (x ̅ age=36, σ=15), from clinical and non-clinical settings, fulfilled a series of questionnaires assessing several variables: sociodemographic data, depression, anxiety, level of BA and the above-cited five sets of PP. Covariance structure analysis will be conducted in order to test the conceptual model mentioned above. RESULTS. Some preliminary results are presented. As expected, a negative significant correlation between depression and BA (r=-.66, p<.01) have been highlighted. Negative significant correlation appeared between BA and the measured PP: self-esteem (r=-.27, p<.01), ruminative thinking (r=-.53, p<.01), environmental reward observation (=-.13, p<.05). Positive significant correlations appeared between BA and mindfulness (r=.49, p<.01) and distress tolerance (r=.26, p<.01). DISCUSSION. The preliminary results are in line with our hypotheses. Indeed, the level of BA is negatively linked to PP usually biased in depression such as self-esteem. The mediating role of these PP between depression and the level of BA will be discussed. [less ▲]

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See detailUse of Inertial Measurement Unit of a Mobile Device to Discriminate Cattle Grazing and Ruminating Behaviours on Pasture
Andriamandroso, Andriamasinoro ULg; Bindelle, Jérôme ULg; Lebeau, Frédéric ULg

in Animal Production in Australia (2014, September)

Precision livestock farming is emerging in the wake of the technological developments in remote sensing and motion monitoring. Tools are developed to allow accurate real time monitoring of the individual ... [more ▼]

Precision livestock farming is emerging in the wake of the technological developments in remote sensing and motion monitoring. Tools are developed to allow accurate real time monitoring of the individual cattle behaviour in a quest to improve the management of pastures. Studies have shown the relevancy of accelerometers in the analysis of behaviour using dedicated devices. Accelerometers are located either close to the mouth or jaw of the animal or on its forehead or neck. Records are usually performed at low frequency (<1Hz) and most studies classify behaviours using neuronal networks or multivariate statistical approaches, with little consideration to the animals’ actual movements. Inertial measurement units (IMU) in consumer mobile devices are specifically developed to record accurately user movements. Besides 3D-accelerometer, they can include 3-D rotational speed sensors, 3-D magnetometers and GPS. Optimised power consumption offers significant autonomy. Data directly acquired from the sensors and IMU signals from build-in proprietary algorithms can be recovered using user-friendly low-cost applications. Moreover, mobile devices can store or communicate information by wireless in real time at high frequency. As movements of cattle are in the same range as humans, this study investigates the relevancy of mobile devices IMU signals to discriminate main behaviours of cattle on pasture. [less ▲]

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See detailDendrochronological research on beech in Belgium: the case of 12th graves from the Nivelles Abbey (Hainaut) and future archaeological prospects
Fraiture, Pascale; Weitz, Armelle ULg; Van Daalen

in Eurodendro 2014 (2014, September)

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See detailEvaluation of the performance of an experimental somnolence quantification system in terms of reaction times and lapses
François, Clémentine ULg; Wertz, Jérôme ULg; Kirkove, Murielle ULg et al

in Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society (2014, August)

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See detailDiversity and correlation of Givetian records in southern Belgium
Pas, Damien ULg; Poulain, Geoffrey; Labaye, Corentin et al

in Berichte des Institutes für Erdwissenschaften der Karl-Franzens-Universität Graz (2014, August), 19

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See detailConsequences of Selection for Environmental Impact Traits in Dairy Cows
Kandel, Purna Bhadra ULg; Vanderick, Sylvie ULg; Vanrobays, Marie-Laure ULg et al

in Proceedings, 10th World Congress of Genetics Applied to Livestock Production (2014, August)

Genetic selection programs aiming to mitigate methane (CH4) emissions require the estimation of genetic correlations with other production and economical traits and predicted selection response. CH4 ... [more ▼]

Genetic selection programs aiming to mitigate methane (CH4) emissions require the estimation of genetic correlations with other production and economical traits and predicted selection response. CH4 intensity was predicted from Mid-infrared spectra of milk samples from Holstein cows. Genetic correlations between CH4 intensity and milk yield (MY) was -0.68, fat yield (FY) -0.13, protein yield (PY) -0.47, somatic cell score (SCS) 0.07, longevity 0.05, fertility 0.31, body condition score (BCS) 0.17. Adding 25% relative weight on CH4 intensity to the current Walloon selection index, the response to selection would reduce CH4 intensity by 24%, increase MY by 30%, FY by 17%, PY by 29%, SCS by -14%, longevity by 24% but also reduce fertility by 11% and BCS by 13%. In conclusion, environmental traits can be added without jeopardizing production traits, but energy balance related traits have to be protected. [less ▲]

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See detailModeling of Uncertainties in Bladed Disks Using a Nonparametric Approach
Nyssen, Florence ULg; Arnst, Maarten ULg; Golinval, Jean-Claude ULg

in Proceedings of the ASME IDETC/CIE 2014 (2014, August)

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See detailAn Econometric Analysis of Homeownership Determinants in Belgium
Xhignesse, Guillaume ULg; Bianchet, Bruno ULg; Cools, Mario ULg et al

in Lecture Notes in Computer Science (2014, July), 8581

In market economies, homeownership is associated with positive ex- ternalities. Increasing the levels of homeownership has been an objective of governments for the last decades. The analysis of the ... [more ▼]

In market economies, homeownership is associated with positive ex- ternalities. Increasing the levels of homeownership has been an objective of governments for the last decades. The analysis of the determinants of tenure sta- tus provides information to this end. This paper proposes an econometric analysis of housing tenure in Belgium. We review the main variables that have been considered in the literature as influencing housing tenure, after what we estimate a logit model. We observe a strong influence of income and age on the probability of homeownership. Couple relationship and the presence of dependent children have a positive influence, but this influence is less significant. Urban location is associated with lower probability of homeownership, compared with other areas. Our observations follow the trends described for other countries in the literature. [less ▲]

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See detailQuantitative Analysis of the Relative Abundance Changes Observed in Type I, III and V Collagen after Suspensory Ligament Injuries in Horses
Shikh Al Sook, Mohamad Khir ULg; Baise, Etienne ULg; Piret, Joëlle ULg et al

in Anatomia, Histologia, Embryologia (2014, July)

Introduction: The equine suspensory ligament (SL) injuries are an important cause of lameness in horses. Quantification of the relative abundance of the constitutive collagen types is essential to ... [more ▼]

Introduction: The equine suspensory ligament (SL) injuries are an important cause of lameness in horses. Quantification of the relative abundance of the constitutive collagen types is essential to investigate the differences between normal and injured tissues. The aim of this original study was to precisely determine the different collagen ratios both in injured and normal SL. This approach is a rational step towards understanding the intimate mechanisms of SL repair and regeneration at the molecular and histological levels. Methods: Five Warmblood horses with visible signs of injury in only one forelimb SL were selected. Specimens were obtained from the central core of lesions in damaged SLs and from the corresponding regions in other healthy SLs. Collagen types I, III and V were purified by differential salt precipitation after collagen extraction with acetic acid containing pepsin and they were examined by transmission electron microscopy. The bands corresponding to types I, III, and V collagen were assessed by densitometry after SDS-PAGE. SAS software (SAS Institute 2001) was used for all statistical analyses. Results: Based on ultrastructural observations, purified fibers of types I, III, and V collagens have been identified. The relative proportions of type III and type V collagen were significantly higher in the specimens‎ from damaged tissue compared with specimens from normal tissue (P < 0.001). These changes were concomitant with significant decrease in type I collagen in the injured tissue (P < 0.001). Conclusions: Our study showed that after SL injury, the relative abundance of the different collagen types is modified. These changes are the molecular hallmark of a decrease in tissue quality and mechanical properties of the ligament. It lays down the bases of subsequent researches on the tissue regeneration that may lead to the development of new treatment strategies for damaged tissues, particularly in the equine SL injuries. [less ▲]

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See detailGalectin-3: a new promising cardiac biomarker in sports endurance?
LE GOFF, Caroline ULg; Devaux, Séverine; BREVERS, Eric ULg et al

in Cardiovascular Research (2014, July), 103(Supplement 1), 255

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See detailLes approches sémiotiques du portrait photographique. De l’identité à l’“air”
Dondero, Maria Giulia ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2014, June 18), 14

L’objectif de cet article est d’abord méthodologique : il entend déployer les instruments de l’analyse sémiotique, et notamment énonciative et temporelle, des images photographiques. Ensuite, il vise à ... [more ▼]

L’objectif de cet article est d’abord méthodologique : il entend déployer les instruments de l’analyse sémiotique, et notamment énonciative et temporelle, des images photographiques. Ensuite, il vise à esquisser la spécificité du genre du portrait et à interroger l’identification de caractéristiques singularisant le portrait d’écrivain. [less ▲]

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See detailSpace radiation parameters for EUI and the Sun Sensor of Solar Orbiter, ESIO and JUDE instruments
Rossi, Laurence ULg; Jacques, Lionel ULg; Halain, Jean-Philippe ULg et al

in Proceedings of SPIE (2014, June 18)

This paper presents predictions of space radiation parameters for four space instruments performed by the Centre Spatial de Liège (ULg – Belgium); EUI, the Extreme Ultra-violet Instrument, on-board the ... [more ▼]

This paper presents predictions of space radiation parameters for four space instruments performed by the Centre Spatial de Liège (ULg – Belgium); EUI, the Extreme Ultra-violet Instrument, on-board the Solar Orbiter platform; ESIO, Extreme-UV solar Imager for Operations, and JUDE, the Jupiter system Ultraviolet Dynamics Experiment, which was proposed for the JUICE platform. For Solar Orbiter platform, the radiation environment is defined by ESA environmental specification and the determination of the parameters is done through ray-trace analyses inside the EUI instrument. For ESIO instrument, the radiation environment of the geostationary orbit is defined through simulations of the trapped particles flux, the energetic solar protons flux and the galactic cosmic rays flux, taking the ECSS standard for space environment as a guideline. Then ray-trace analyses inside the instrument are performed to predict the particles fluxes at the level of the most radiation-sensitive elements of the instrument. For JUICE, the spacecraft trajectory is built from ephemeris files provided by ESA and the radiation environment is modeled through simulations by JOSE (Jovian Specification Environment model) then ray-trace analyses inside the instrument are performed to predict the particles fluxes at the level of the most radiation-sensitive elements of the instrument. [less ▲]

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See detailSolar simulation test up to 13 solar constants for the thermal balance of the Solar Orbiter EUI instrument
Rossi, Laurence ULg; zhukova, Maria; Jacques, Lionel ULg et al

in Proceedings of SPIE (2014, June 18)

Solar Orbiter EUI instrument was submitted to a high solar flux to correlate the thermal model of the instrument. EUI, the Extreme Ultraviolet Imager, is developed by a European consortium led by the ... [more ▼]

Solar Orbiter EUI instrument was submitted to a high solar flux to correlate the thermal model of the instrument. EUI, the Extreme Ultraviolet Imager, is developed by a European consortium led by the Centre Spatial de Liège for the Solar Orbiter ESA M-class mission. The solar flux that it shall have to withstand will be as high as 13 solar constants when the spacecraft reaches its 0.28AU perihelion. It is essential to verify the thermal design of the instrument, especially the heat evacuation property and to assess the thermo-mechanical behavior of the instrument when submitted to high thermal load. Therefore, a thermal balance test under 13 solar constants was performed on the first model of EUI, the Structural and Thermal Model. The optical analyses and experiments performed to characterize accurately the thermal and divergence parameters of the flux are presented; the set-up of the test, and the correlation with the thermal model performed to deduce the unknown thermal parameters of the instrument and assess its temperature profile under real flight conditions are also presented. [less ▲]

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See detailSUITABILITY OF 24,25(OH)2 VITAMIN D3 DETERMINATION WITH AN ADAPTED VERSION OF THE CHROMSYSTEMS® MASSCHROM® 25-OH-VITAMIN D3/D2– LC-MS/MS KIT
SCHLECK, Marie-Louise ULg; NETCHACOVITCH, Matthieu ULg; CRINE, Yannick ULg et al

in Clinical Chemistry & Laboratory Medicine (2014, June), 52(Special Suppl), 1235

BACKGROUND: The enzym CYP24A1 catalyses the conversion of 25(OH)D3 in 24,25(OH)2D3. Recently, loss-of-function mutation of CYP24A1 has been identified in idiopathic infantile hypercalcemia (IIH). This ... [more ▼]

BACKGROUND: The enzym CYP24A1 catalyses the conversion of 25(OH)D3 in 24,25(OH)2D3. Recently, loss-of-function mutation of CYP24A1 has been identified in idiopathic infantile hypercalcemia (IIH). This genetic defect can be highlighted by high 1,25(OH)2D3 and undetectable 24,25(OH)2D3 levels. 24,25(OH)2D3 is also known to interfere with 25(OH)D3 determinations with immunoassays, leading to an overestimation of the 25(OH)D3 concentrations. We adapted the MassChrom kit on the AB SCIEX TQ 5500 in order to systematically provide, next to 25(OH)D3, 25(OH)D2 and C3 epimer, the concentrations of 24,25(OH)2D3. The aim of this study was to evaluate the performance of 24,25(OH)2D3 determination with this modified method. We also wanted to establish the reference value of 24,25(OH)2D3. METHODS: We modified the Chromsystems MassChrom method by adding the 24,25(OH)D3 correspondent transitions and performed a calibration by spiking known amounts of 24.25(OH)2D3. The LOQ was determined with 10 concentration levels of 24,25(OH)2D3. We selected 92 healthy children (40 girls; 2.4±1.51 years) presenting normal calcium levels (2.49±0.13mmol/l) to determine the 95th percentile (p95). RESULTS: The 24,25(OH)2D3 LOQ was 4.7 ng/ml. 85.9% of our subjects were below this LOQ. The p 95 for the 24,25(OH)2D3, according to the CLSI C28-A3, was <6.2 ng/ml. The average serum concentrations (mean±SD) of 25(OH)D3 and 3-epi-25(OH)D3 were 24.48±10.22ng/ml and 2.07±1.86 ng/ml respectively. The 24,25(OH)2D3 levels (r2=0.64) correlated with the 25(OH)D3 levels. CONCLUSIONS: Our adapted method from Chromsystems Vitamin D determination is available to quantify 24,25(OH)2D3. In this context, this method is able to determine high levels of 24,25(OH)2D3 that can possibly cross react with immunoassays. However, as the LOQ was not low enough, we couldn’t establish correct reference value for 24,25(OH)2D3. A derivatization step in the sample preparation would be interesting to improve the sensibility of the method. [less ▲]

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See detailPlatelet-rich plasma to treat patellar tendinopathies: a 1 year follow-up.
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in Clinical Chemistry & Laboratory Medicine (2014, June), 52(Special Suppl), 1285

Background: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

Background: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. Infiltration of Platelet Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of the current study is to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies up to 1 year after 1 infiltration of PRP. Methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months and 1 year after the infiltration, using a 10-point Visual Analogic Scale and algofunctional scores (IKDC and VISA-P). Moreover, they had to answer an information questionnaire concerning their life and sports activities. The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. Results: Pain during daily activities significantly decreased with time. VAS has significantly dropped, IKDC and VISA-P significantly improved over the follow-up of 1 year. Seventy percents of patients reported a favourable evolution with decrease of pain, 15% did never report any improvement and 15% were treated surgically. Seventy percents returned to sports activities, 64,3% without any pain, and 50% of them recovered the same sport level. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. Conclusions: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve, at 1 year, symptoms of chronic jumper’s knee in patients non-responsive to classical conservative treatments. [less ▲]

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See detailURINARY AND SALIVARY CORTISOL IN LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY: METHOD VALIDATION AND EXPECTED VALUES DETERMINATION
LE GOFF, Caroline ULg; DELCOUR, Sandra ULg; PEETERS, Stéphanie ULg et al

in Clinical Chemistry & Laboratory Medicine (2014, June), 52(Special Suppl), 1241

BACKGROUND: Cortisol measurement is useful in evaluation of Cushing syndrome, adrenal insufficiency, mineralocorticoid excess and congenital adrenal hyperplasia. We developed a liquid ... [more ▼]

BACKGROUND: Cortisol measurement is useful in evaluation of Cushing syndrome, adrenal insufficiency, mineralocorticoid excess and congenital adrenal hyperplasia. We developed a liquid chromatography–tandem mass spectrometry (LCMS/MS) method for salivary and urinary cortisol and we determined the 95th percentile (p95) for the urinary and salivary cortisol. We compared them to the Mayo Clinic expected values. METHODS: Saliva at 8 am and 11 pm and 24h urine were obtained from 32 healthy (22 female, 34.3±9.3 yo) volunteers. We performed validation with the enoval software (Arlenda, Belgium). For the validation, we used water or urine with spiked known amounts of cortisol for the CORS and CTU respectively. For the CORS, samples were centrifuged, deuterium labelled cortisol was added as internal standard and the protein precipated by acetonitril. The supernatant was evaporated, dissolved in methanol acidified with acetic acid and analyzed by LCMS/MS. For CTU, samples were centrifuged, deuterium labelled cortisol was added as internal standard and diluted by the ammonium acetate and analyzed by LCMS/MS. At the Mayo Clinic, the expected values were 1-7.5 μg/L (7 a.m-9 a.m) and <1 μg/L (11-12 p.m) for CORS and 3.5-45 μg/24h (<18yo) for CTU. RESULTS: For the CTU, the with-in run did not exceed 3% (0.4-3%) and the between-run did not exceed 3.1% (0.4-3.1%) for 1.5-750 μg/L. The limit of quantification was 1.5 μg/L. The linearity was good between 1.5 and 750 μg/L. The recovery is 97.9±2.2% (95%CI for the mean: 92.4-101.1%). For the CORS, the with-in run and between run did not exceed 8% (1.9-8%) for 1.15-8.65 μg/L. The limit of quantification was 1.15 μg/L. The analyse presents a good linearity between 1.15 and 8.65 μg/L. The recovery is 99.9±2.9% (95%CI for the mean: 94.2-108.7%). The p95 for the CTU according to the CLSI C28-A3 was 33 μg/24h, and for the CORS was 5.42 μg/L at 8 am and 0.7 μg/L at 12 pm. CONCLUSIONS: Our developed method in liquid chromatography tandem mass spectrometry was validated for the measurement of urinary and salivary cortisol. Our findings indicate that the proposed analytical methods were suitable for routine purposes and useful in many pathological conditions.The expected values confirm these defined by the Mayo Clinic. [less ▲]

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See detailEvaluation of troponin T on AQT90 Flex and COBAS 8000 as a rule in/out tool in an emergency ward
LE GOFF, Caroline ULg; EVRARD, Séverine ULg; BREVERS, Eric ULg et al

in Clinical Chemistry & Laboratory Medicine (2014, June), 52(Special Suppl), 510

BACKGROUND: Troponin measurement is the gold standard for diagnosis of Acute Myocardial Infarction (AMI). Troponin (highly sensitive (hs), T or I) is measured by immunochemistry instrument or by Point of ... [more ▼]

BACKGROUND: Troponin measurement is the gold standard for diagnosis of Acute Myocardial Infarction (AMI). Troponin (highly sensitive (hs), T or I) is measured by immunochemistry instrument or by Point of Care (POCT). POCT can be useful in emergency lab or ward for a faster diagnosis of patients with chest pain. Our study compared analytical performance of a POCT AQT90 Flex (Radiometer Medical) (AQT) and TnThs Cobas 8000 (Roche Diagnostics) (Cobas). We also compared the clinical performance of both methods at recommended cut-off (14 ng/L for Cobas and 30 ng/ L for AQT). METHODS: We selected 104 patients (296 samples) (range: 6-13822 ng/L) admitted in the Emergency ward for which at least 1 troponin determination (Cobas 8000) had been re-quested in the past 24 hours according to rule in/out procedure applied by this ward. Samples were then measured with the AQT. Inter-assay CV was maximum 8.6% and 9.6% for Cobas and AQT respectively. The cut-off defined as the 99th percentile for Roche was 14 ng/L and the recommended decision threshold value was 30 ng/L for Radiometer. Retrospective analysis of final diagnostic was obtained for all participants: we considered as “true positive” patients for whom a final diagnostic was ST segment-Elevation Myocardial Infarction (STEMI) or non STEMI (NSTEMI). RESULTS: On the whole range of measure, the 2 methods showed a good correlation (r2=0.98). Regression equation was Cobas = 0.98 AQT + 31 ng/L (95%CI of the intercept: (26.7;37.7) and 95% CI of the slope (0.96;1)). When we stratified, for the values <54 ng/L, the equation became Cobas = 0.52 AQT +1.1 ng/L (95%CI of the intercept: (-4.8;5.5) and 95% CI of the slope (0.39;0.69)). Bland and Altman plot did not show any bias. At admission [2-7 hours], 78 (81%) of admitted patients were finally considered as AMI, sensitivity was 92 % [96%] for Cobas and 78% [91%] for AQT. Specificity was 15% for Cobas (cut-off 14ng/L) or 73% (cut-off 54 ng/L) and 76% for AQT. CONCLUSIONS: Overall, there was a good correlation between the 2 methods. However, using a cut-off of 14 ng/L for Cobas is questionable for a rule in/out procedure in an emergency ward. Using 54 ng/L for Roche and 30 ng/L for AQT would have led to the best discrimination between patients presenting AMI or not. [less ▲]

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See detailMallarmé dans la prison des signes
Durand, Pascal ULg

in Cahiers du CérédI (2014, June), 10

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See detailSYMPOSIUM: Activité et cerveau vieillissant - Nature du lien et impact pour la prévention et de l’intervention
Belleville, Sylvie; Adam, Stéphane ULg

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014, May 15), 12(Supplément 1), 23-25

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See detailInvestigation of spectral impacts on the performance of a concentration device using a Fresnel lens combined with a double junction cell
Loicq, Jerôme ULg; Galante, Nicolas ULg; Thibert, Tanguy ULg et al

in Proc. SPIE 9140, Photonics for Solar Energy Systems V, 91400T (2014, May 15)

This experimental study was carried out within the context of high concentration photovoltaics. The paper presents the results of an experimental investigation relating to the quantification of the ... [more ▼]

This experimental study was carried out within the context of high concentration photovoltaics. The paper presents the results of an experimental investigation relating to the quantification of the impacts of the chromatic effect on the performance of a double junction GaInP/GaAs solar cell. Chromatic effects are the result of material dispersion caused by the refractive optics component. This study aims to evaluate the effect of the spectral modification of the incident beam on the whole solar concentrator system performance. Such considerations are fundamental in producing a highly accurate design, with which to achieve the best possible system performance. Efficiency is evaluated within the vicinity of the focus of a Fresnel lens designed for concentration. On the optical axis, rays with different wavelengths are not focalized at the same points. The spectral content of the beam depends, therefore, upon the position of the cell along the optical axis. It is assumed that spectral content modification may have an impact on cell performance and, as a consequence, on system efficiency as a whole. Efficiency of the optical Fresnel lens and of the cell were evaluated in relation to spectral content modification. [less ▲]

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See detailSpectral splitting planar solar concentrator : Design and Experimental testing Preliminary results
Blain, Pascal ULg; Michel, Céline ULg; Clermont, Lionel ULg et al

in Proceedings of SPIE (2014, May 15), 9140

We present a new concept in solar concentrator: spectral splitting. It implies reflective, refractive and diffractive elements that allow two spectrally differentiated beams to reach different and/or ... [more ▼]

We present a new concept in solar concentrator: spectral splitting. It implies reflective, refractive and diffractive elements that allow two spectrally differentiated beams to reach different and/or unmatched lattice solar cells. Those cells efficiencies are then enhanced. The aimed geometrical concentration factor is 5× and the theoretical optical efficiency of that concentrator concept reaches 82%. [less ▲]

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See detailComparison of off-axis TMA and FMA telescopes optimized over different fields of view: applications to Earth observation
Clermont, Lionel ULg; Stockman, Yvan ULg; Dierckx, Wouter et al

in Proceedings of SPIE (2014, May 01), 9131

TMA, or three mirror anastigmats, have already been used successfully for various space missions. In the frame of earth observation, ProbaV satellite uses 3 TMAs to cover a total 102.4° field-of-view ... [more ▼]

TMA, or three mirror anastigmats, have already been used successfully for various space missions. In the frame of earth observation, ProbaV satellite uses 3 TMAs to cover a total 102.4° field-of-view; ground sampling distance is about 100m at the center of field-of view and 370m at the edge. For future earth observation missions, the goal would be to reach 100m spatial resolution all over the 102.4° FOV. This would require to up-scale optical specifications, thus increasing geometrical aberrations. FMA, or four mirror anastigmats, could thus be a good candidate for future missions, as a fourth mirror would allow better correction of optical aberrations. In this work, TMA and FMA have been optimized over different fields-of view. Performance limitations are then derived, which show that FMA seems promising for future missions. Radiometry aspects are discussed and preliminary tolerance analysis is carried out. [less ▲]

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See detailFirst prototypes of vortex retarders obtained by polarization holography
Piron, Pierre ULg; Blain, Pascal ULg; Décultot, Marc ULg et al

in Proceedings of SPIE (2014, May), 9099

This paper will present the first prototypes of vortex retarders made of photo-orientable liquid crystals polymers recorded without mechanical action using only polarization holography. Vortex retarders ... [more ▼]

This paper will present the first prototypes of vortex retarders made of photo-orientable liquid crystals polymers recorded without mechanical action using only polarization holography. Vortex retarders are birefringent plates characterized by a uniform phase retard and a rotation of their fast axis along their center. Liquid crystals are anisotropic molecules possessing birefringent properties. They are locally orientable and their orientation defines the fast axis orientation of the retarder. Their alignment depends on the local orientation of the recording electric field. The superimposition of several polarized beams will be used to shape the electric field to achieve the recording of vortex retarders. The mathematical aspects of the superimposition process, as well as several numerical simulations are exposed. Finally, the first prototypes are presented, characterized and compared to the numerical simulations. [less ▲]

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See detailLa recherche de demain sur le vieillissement
Adam, Stéphane ULg

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014, May), 12(Supplément 1), 4-5

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See detailNo interest for a second close infiltration of platelet-rich plasma to treat upper patellar tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Buhler, Frédéric et al

in European Journal of Physical and Rehabilitation Medicine (2014, May), 50(Suppl. 1 to No. 3), 21639-002-

Background: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to ... [more ▼]

Background: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. The aim of this study was to evaluate whether 2 infiltrations of PRP proves more effective than a single treatment. Methods: Twenty patients suffering from jumper’s knee for over than 3 months were enrolled into the study and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. Conclusion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups after a follow-up period of 3 months. A second closely-timed infiltration of PRP to treat jumper’s knees is not necessary to improve the efficacy of this treatment in the short term. [less ▲]

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See detailCinacalcet treatment at the time of transplantation is associated with a significant risk of delayed graft function in kidney transplant recipients
Jouret, François ULg; WEEKERS, Laurent ULg; GROSCH, Stéphanie ULg et al

in Transplant International (2014, May), 27(S1), 167

The calcium-sensing receptor (CaSR) has been implicated in the ischemia/ reperfusion (I/R) cascade in heart, liver and brain. Renal I/R occurs at the time of transplantation (Tx), with a deleterious ... [more ▼]

The calcium-sensing receptor (CaSR) has been implicated in the ischemia/ reperfusion (I/R) cascade in heart, liver and brain. Renal I/R occurs at the time of transplantation (Tx), with a deleterious impact on early graft function. Here, we retrospectively investigated if the use of cinacalcet, a CaSR agonist, in kidney transplant recipients (KTR) influences early graft recovery. All KTR from 2007 to 2012 in our Academic Hospital were prospectively included in a database. Patients actively treated with cinacalcet on the day of Tx were retrospectively identified from this database and matched with controls on (i) type of donor (living [LD], deceased after brain or circulatory death [DCD]); (ii) cold ischemic time (CIT) ` 1 h; (iii) residual diuresis (` 500 ml); and (iv) donor age (` 5 years). Delayed graft function (DGF) was defined as dialysis requirement after Tx. Baseline characteristics were compared between groups with student’s t-test or Chi-2 as appropriate. The endpoint was the percentage of DGF in both groups. Among 337 KTR, 36 (10.7%) were treated with cinacalcet at Tx. Control group included 61 patients. Characteristics of patients and donors are summarized in the table. DGF occurred in 42 and 23% of cinacalcet-treated and control groups, respectively (p = 0.05). These retro- spective observations suggest that CaSR activation at the time of Tx impairs early graft recovery. [less ▲]

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See detailWhat you should know before starting minimal invasive liver resection: an overview
DETRY, Olivier ULg

in Acta Chirurgica Belgica (2014, May), 114(3), 117

Laparoscopic liver surgery has evolved over the last 2 decades. Advancements in surgical technology, surgical technique, and postoperative care have aided in lifting barriers to laparoscopic liver ... [more ▼]

Laparoscopic liver surgery has evolved over the last 2 decades. Advancements in surgical technology, surgical technique, and postoperative care have aided in lifting barriers to laparoscopic liver resections (LLR). LLR might decrease morbidity and hospitalisation stay compared to open approach, and importantly in liver surgery, may decrease postoperative costal pain. However, in hepatic surgery as in all abdominal procedures, laparoscopic approach is a mean but not a goal. The possibility of LLR should neither modify indications for surgery nor the type of resection. Physiologic modifications induced by CO2 pneumoperitoneum should be known by the surgical and anaesthetic team involved in LLR. Pneumoperitoneum decreases cardiac output, and this decrease could be worsened by the reverse Trendelenburg position and by hepatic hilar clamping. CO2 pneumoperitoneum decreases hepatic blood flow. This is a clear advantage for limiting blood loss during LLR, but this also might increase liver ischemia during Pringle liver hilum clamping, a manoeuvre that should be avoided in LLR. Low venous pressure might decrease blood loss by the small supra hepatic veins, but may also further decrease cardiac output. Several devices may be used for liver section, without evidence of the superiority of one device compared to others. Endo GIA might be very helpful to control the major liver vessels, as branches of portal vein or suprahepatic veins. Significant CO2 embolism is a rare complication, and conversion to open approach for haemorrhage should be performed only if blood loss is controlled. Up to now, there is no clear scientific evidence that laparoscopic approach provides any advantage compared to open approach. SILS, LESS or even robotic approaches should only considered as purely experimental. Current barriers to LLR will continue to fall in the future. [less ▲]

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See detailOne-year follow-up of platelet-rich plasma to treat chronic upper patellar tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in European Journal of Physical and Rehabilitation Medicine (2014, May), 50(Suppl. 1 to No. 3), 227250-

Introduction: Infiltration of PRP may be used as a recent therapeutic option for chronic tendinopathies The aim of the current study is to evaluate the clinic and the return to sports activities in ... [more ▼]

Introduction: Infiltration of PRP may be used as a recent therapeutic option for chronic tendinopathies The aim of the current study is to evaluate the clinic and the return to sports activities in patients with chronic upper patellar tendinopathies 1 year after 1 infiltration of PRP. Material and methods: The follow-up of 20 subjects who beneficed from 1 infiltration of PRP was made before infiltration, after 3 months and 1 year after infiltration; it was made as follow: VAS, IKDC and VISA-P scores. Moreover, they had to answer an information questionnaire concerning their life and sports activities. Results: Seventy percents of patients reported a favourable evolution with decrease of pain, 10% did never report any improvement and 20% were treated surgically. Eighty-seven percents returned to sports activities without any pain, and 50% of them recovered the same sport level. VAS has significantly (p<0.0001) dropped, IKDC significantly improved (p=0.0007) and VISA-P also significantly increased (p=0.0087) over the follow-up of 1 year. Discussion: This study confirms that a local injection of PRP coupled with a program of eccentric rehabilitation through a chronic Jumper's knee, improves painful symptoms and the functionality of the subjects’ knee up to a follow-up of 1 year. [less ▲]

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See detailEccentric training for elbow hypermobility
Kaux, Jean-François ULg; Delvaux, François ULg; Forthomme, Bénédicte ULg et al

in British Journal of Sports Medicine (2014, April), 48(7), 154

Background: Patients with hypermobility suffer from joints problems and chronic pain is the most frequently reported symptom. Objective: Eccentric muscle strengthening could be very important to protect ... [more ▼]

Background: Patients with hypermobility suffer from joints problems and chronic pain is the most frequently reported symptom. Objective: Eccentric muscle strengthening could be very important to protect hypermobile joints. Design: Case report. Patient: A girl (16 y.o.) affected by an Ehler-Danlos syndrome presented pain in the right elbow and the right wrist after a season of tennis. Interventions: Her training consisted of wrist prono-supination and flexion-extension muscle group reinforcement and proprioceptive training. To protect the wrist against excessive load, the eccentric strengthening exercises of prono-supinator and flexor-extensor muscles of elbow and wrist were undertaken gradually, at increasing speeds within a limited range of motion in flexion and extension, on an isokinetic device after an evaluation. She was also given an orthesis restricting the joint range of motion of the wrist. Main outcome measurements: The evaluation was made by isokinetic evaluation, visual analog scale and MOS-SF36 questionnaire before and after training. Results: The patient rapidly noted a decrease in pain and an increase in the stability of her right arm even when playing tennis. Isokinetic evaluation objectified a significant improvement in maximal torque in flexion-extension muscles of the right elbow. She was also given individualized home exercises. Conclusions: The goal of this eccentric training is to avoid hypermobility by using the muscles as a protective brake in the control of joint positioning. Muscles can be reinforced in eccentric mode with starting position at the maximum length of these muscles when unstreched. The exercises can be carried out safely on an isokinetic device, at slow speed and limited range of joint motion to avoid risk of luxation. Thus, in this case report, the eccentric exercises using an isokinetic device were effective to safely reinforce the muscles as a protective brake for joint hypermobility and prevent pain during practicing tennis. [less ▲]

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See detailCardiac troponins and natriuretic peptides in runners: useful for cardiac risk screening ?
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Fillet, Marianne ULg et al

in British Journal of Sports Medicine (2014, April), 48(7), 173

Background Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. Objective Our aim was to compare ... [more ▼]

Background Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. Objective Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Design Prospective, cohort study. Setting Amateur marathon runners and ultrarunners. Patients 28 subjects (26 men, 42.5±11 yrs) were enrolled. Interventions Subjects ran the Maasmarathon (42.195 kilometers) and 33 subjects (33 men, 45.7±9.3 yrs) ran the Ultratour of Liège (Belgium; 67 km). All subjects gave their informed consent. We took blood sample before (T0), just after (T1) and 3 hours after the race (T3). Main outcome measurements cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. All statistical analyses were performed using Medcalc version 8.1 for Windows. P-value <.01 was regarded as statistically significant. Results A significant difference between hsTnT concentrations at T0 and T1 (P<.001), and between T0 and T3 (P<.001) for NT-proBNP have been observed, but not between T1 and T3. This observation appeared only after a strenuous exercise. However, up to now this type of exercise is not reproducible easily in a laboratory. Moreover, nobody knows if these observations would have cardiac consequences at long terms. Conclusion Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death. [less ▲]

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See detailTwo biomarkers for the screening of cardiac risk among runners ?
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Fillet, Marianne ULg et al

in British Journal of Sports Medicine (2014, April), 48(7), 174

Background Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. Troponin T is a ... [more ▼]

Background Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. Troponin T is a component of the contractile apparatus of the striated musculature. Both are early markers for acute coronary syndrome. Objective The aim of our study was to compare the results obtained with the H-FABP and the highly sensitive cardiac troponins (hsTnT) and to test their cardiospecificity in healthy runners. Design Prospective, cohort study. Setting Amateur marathon runners. Patients 23 runners (marathon) were enrolled. Interventions We drowned blood samples at three times: just before (T0), just after (T1), and three hours after the end of the race (T3). Main outcome measurements H-FABP and hs-TnT were performed according to the manufacturer's instructions. A linear regression was calculated to observe if there is any correlation between the two biomarkers. Values above the 95th percentile for H-FABP (2.5 ng/mL) and the 99th percentile for hsTnT (14 ng/L) were considered as positive. Results At T0, none of the subjects were positive for hsTnT but 35% were positive for H-FABP; at T1, 83% for hsTnT and 100% for H-FABP; at T3, 83% for hsTnT and 96% for H-FABP. At T0, the regression equation was H-FABP T0=3.9454–0.1001×hsTnT T0; at T1: H-FABP T1=51.838–1.7026×hsTnT T1; at T3: H-FABP T3=47.977–1.6193×hsTnT T3. No correlation was observed between the 2 biomarkers. Conclusion We observed a significant increase of H-FABP and hsTnT in runners. These markers are independent to each other. These values could biologically correspond to a heart ischemia. These biomarkers could be helpful for the screening of cardiac risk among runners. [less ▲]

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See detailLa discussion à visée démocratique et philosophique au prisme de la critique deleuzienne de la discussion. Analyse d'un verbatim.
Herla, Anne ULg; Jeanmart, Gaëlle

in Diotime. Revue internationale de didactique de la philosophie. (2014, April), 60

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See detailEccentric training improves tendon biomechanical properties: a rat model
Kaux, Jean-François ULg; Drion, Pierre ULg; Libertiaux, Vincent et al

in British Journal of Sports Medicine (2014, April), 48(7), 155

Background: Even if eccentric exercises appear favourable in primary prevention of tendons lesions and, especially, in secondary prevention after tendinopathy, the biomechanical changes to the tissue are ... [more ▼]

Background: Even if eccentric exercises appear favourable in primary prevention of tendons lesions and, especially, in secondary prevention after tendinopathy, the biomechanical changes to the tissue are not yet clear. Objective: We aimed to better define the biomechanical changes that affect healthy tendon after eccentric and concentric training. Design: Randomised controlled trial. Participants: Eighteen Sprague-Dawley rats of 2 months. Interventions: The six rats in the control group (U) were not subjected to physical exercise. The 12 remaining rats (6 in each group) ran on a treadmill set at a +15° incline for concentric training (C) or a -15° incline for eccentric training (E), at a speed of 17 m/min for 1 h, three times per week for 5 weeks. Main Outcome Measurements: The tricipital, patellar and Achilles tendons were subsequently removed to perform a traction test until rupture, and a histological analysis was performed. Results: There was a significant improvement in the rupture force of the patellar and tricipital tendons between the U and E groups. The tricipital tendons in the control group presented a significantly smaller cross-section than the E- and C-trained groups, but none between E and C groups. No significant difference was observed for the mechanical stress at rupture per surface unit between the three groups for all three tendons. However, a tendency towards improvement these values was observed between the trained and the U groups for the patellar tendon. Histological studies demonstrated the tendency of the development of a greater number of blood vessels and a larger quantity of collagen in the eccentric group. Conclusions: The mechanical properties of tendons in rats improve after specific training, especially following eccentric training. Our results partly explained how mechanical loading, especially in eccentric mode, could improve the tendon structure. [less ▲]

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See detailMultitasking capacities in persons diagnosed with schizophrenia: A preliminary examination of their neurocognitive underpinnings and ability to predict real world functioning
Laloyaux, Julien ULg; Van der Linden, Martial ULg; Levaux, Marie-Noëlle ULg et al

in Schizophrenia Research (2014, April), 153(Supl. 1), 344

Background: Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia. Moreover, patients seem to demonstrate particular difficulties during complex and ... [more ▼]

Background: Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia. Moreover, patients seem to demonstrate particular difficulties during complex and multitasking activities, such as cooking a meal (Semkovska et al., 2004). Multitasking refers to activities where the person has to: carry out and alternate between different tasks that vary in terms of priority, difficulty and duration; define the tasks’ targets; and where the person is faced with unexpected problems during the realization of these tasks (Burgess, 2000). However, at present, patients’ multitasking capacities have not been adequately examined in the literature due to an absence of suitable assessment strategies. We thus recently developed a computerized real-life activity task designed to take into account the complex and multitasking nature of certain everyday life activities where participants are required to prepare a room for a meeting – the Computerized Meeting Preparation Task (CMPT) Methods: Twenty-one individuals diagnosed with schizophrenia and 20 matched healthy controls completed the CMPT. During the CMPT, participants found themselves in a virtual room that they had to prepare for a meeting while respecting a list of instructions (the placement of the guests, the needed objects, the desired drinks, etc.). Patients were also evaluated with an extensive cognitive battery (assessing executive functions, attention, processing speed and memory), measures of symptomatology and real world functioning. To examine the ecological validity of the CMPT, 14 others patients were recruited and were given the computerized version and a real version of the meeting preparation task. Results: Results demonstrated that performance on the CMPT significantly differentiated patients and healthy controls for the total time to complete task, planning efficiency, and the respect of the instructions. Moreover, these variables were significantly correlated with executive functioning (i.e. cognitive flexibility and planning), suggesting the major implication of these cognitive processes in multitasking activities. Performance on the CMPT also significantly predicted up to 50% of real world functioning. Finally, performances on the computerized version and the real version of the meeting preparation task were highly correlated, suggesting good ecological validity. Discussion: In this study, we created a novel task involving the multitasking nature of real world activities. The results demonstrated that this approach provides a good indication of the real world functioning in patients diagnosed with schizophrenia. Moreover, results suggest a particular implication of executive functioning in multitasking activities. These findings suggest the importance of evaluating multitasking capacities in patients diagnosed with schizophrenia in order to predict real world functioning. [less ▲]

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See detailDe rol van de bibliotheek in tijden van information overload
Decoster, Sara ULg

in Cahiers de la Documentation = Bladen voor Documentatie (2014, March), 68(1),

Cet article étudie le rôle que peut jouer la bibliothèque en temps d’information overload et part des deux composantes de base du phénomène de l’infobésité : en premier lieu, un flot de données ... [more ▼]

Cet article étudie le rôle que peut jouer la bibliothèque en temps d’information overload et part des deux composantes de base du phénomène de l’infobésité : en premier lieu, un flot de données objectivement important, et, en second lieu, la manière dont ces données sont traitées par le sujet humain, l’usager. Pour gérer l’afflux de données constant, la bibliothèque offre d’abord un outillage technique. Le développement récent des outils « discovery » peut être resitué dans cette veine. Deuxièmement, c’est en investissant dans les compétences informationnelles des utilisateurs que la bibliothèque peut lutter contre le versant subjectif de l’infobésité. Dans ce processus, la communication joue un rôle primordial. [less ▲]

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See detailControlled DCD donation is part of the solution to liver graft shortage, regardless of donor age
DETRY, Olivier ULg; MEURISSE, Nicolas ULg; DELWAIDE, Jean ULg et al

in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 16

Aim: Results of donation after circulatory death (DCD) liver transplantation (LT) are impaired by ischemic bile duct lesions caused by procurement warm ischemia. Donor age is a risk factor in deceased ... [more ▼]

Aim: Results of donation after circulatory death (DCD) liver transplantation (LT) are impaired by ischemic bile duct lesions caused by procurement warm ischemia. Donor age is a risk factor in deceased donor LT, and particularly in DCD-LT. At the authors institute, age is not an absolute exclusion criterion to discard DCD liver grafts, controlled DCD donors receive comfort therapy before withdrawal, and cold ischemia is minimized. The aim of the present study was to report on the results of the first 10 years of this experience, and particularly on graft survival and the rate of post-transplant biliary complications, according to DCD donor age. 
 Methods: The authors retrospectively studied a consecutive series of 70 DCD-LT performed from 2003 to 2012, with at least one year of follow-up. This series was divided according to donor’s age, including 32 liver grafts from donors <55years, 20 between 56 and 69 years, and 18 from older donors >69 years. The three groups were compared in terms of donor and recipient demographics, procurement and transplantation conditions, peak laboratory values during the first post-transplant 72 hours, and results at one and four years. Median follow-up was 43 months. 
 Results: Overall graft survival was 98.5%, 91.4% and 69.5% at 1 month, 1 year and 4 years, respectively, without graft loss secondary to ischemic bile duct lesions. Cancer was the primary cause of graft loss and patient death. No difference other than age was noted between the three groups in donor and recipient characteristics, and in procurement conditions. There was no primary non-function but one patient needed re-transplantation for artery thrombosis. Biliary complications occurred similarly in the three groups. Graft and patient survival rates were not different at one and four years between the three groups. During the study period, there was an increasing liver procurement and transplantation activity, and in 2012, 30% of performed LT were DCD-LT, allowing a mean LT waiting time of 66 days. 
 Conclusions: This study shows comparable results between controlled DCD-LT from younger and older donors. Donor age >50 years should not be a contraindication to DCD-LT if other donor risk factors (such as warm and cold ischemia time) are minimized. DCD-LT with short cold ischemia may provide a significant source of liver grafts, decreasing waiting time. [less ▲]

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See detailTGF-B induced protein IG-H3 is essential for the growth of human liver metastases
Castronovo, Vincenzo ULg; Blomme, Arnaud; Delvenne, Philippe ULg et al

in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 05

Introduction : Transforming growth factor-beta-induced protein ig-h3 (TGFBI) is extracellular matrix component known to be important for cell-collagen interaction. We and others have reported elevated ... [more ▼]

Introduction : Transforming growth factor-beta-induced protein ig-h3 (TGFBI) is extracellular matrix component known to be important for cell-collagen interaction. We and others have reported elevated expression of TGFBI in sev- eral human cancers, where its role remains controversial. Aim Current study aims at clarifying the function of TGFBI to date. Methods &Results : CRC-LM and in liver metastases originating from breast, lung and pancreatic tumors. We have next focused on func- tional aspects and have silenced TGFBI expression in SW1222 human colorectal carcinoma cells. The suppression of TGFBI protein led to a marked decrease in cell migration (-70%) and proliferation (-30%) in vitro. To study the effects in vivo we have developed a novel animal model of colorectal carcinoma based on chicken chorioallantoic membrane (CAM) that mimics human CRC-LM. TGFBI silencing resulted in 50% reduction of tumor volume in the CAM tumor model. Notably, the tumors displayed a marked inhibition of vascularization, suggesting an additional anti-angiogenic effect. Indeed, SW1222 cells silenced for TGFBI expression secreted lower levels of VEGFA in vitro. Finally, we have investigated if TGFBI can be used as systemically reachable target for antibody-drug delivery. For this purpose we have The in vivo data demonstrated that TGFBI is an accessible tumor target. Conclusions : Taken together, the present study shows that TGFBI is essential for promoting the development of CRC- LM and therefore represents a promising target for designing novel therapeutic approaches. [less ▲]

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See detailOrganized proteomic heterogeneity in colorectal liver metastases and implications for therapies
Turtoi, Andrei ULg; Blomme, Arnaud ULg; Debois, Delphine ULg et al

in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 07

Introduction : Tumor heterogeneity is a major obstacle for developing effective anti-cancer treatments. Recent studies have pointed at large stochastic genetic heterogeneity within cancer lesions, where ... [more ▼]

Introduction : Tumor heterogeneity is a major obstacle for developing effective anti-cancer treatments. Recent studies have pointed at large stochastic genetic heterogeneity within cancer lesions, where no pattern seems to exist that would enable a more structured targeted therapy approach. Aim : Because to date no similar information is available at the protein (phenotype) level, we aimed at characterising the proteomic heterogeneity in human colorectal carcinoma (CRC) liver metastases. Methods & Results : We employed MALDI imaging-guided proteomics and explored the heterogeneity of extracellular distribution of over 1000 proteins we found unexpectedly that all liver metastasis lesions displayed a reproducible, zon- ally delineated, pattern of functional and therapeutic biomarker heterogeneity. Peritumoral region featured elevated lipid metabolism and protein synthesis, the rim of the metastasis displayed increased cellular growth, movement and drug metabolism whereas the center of the lesion was characterized by elevated carbohydrate metabolism and DNA- repair activity. From the aspect of therapeutic targeting zonal expression of known and novel biomarkers was evident, reinforcing the need to select several targets in order to achieve optimal coverage of the lesion. Finally we highlight two novel antigens, LTBP2 and TGFBI, whose expression is a consistent feature of CRC liver metastasis. Conclusions : proteome heterogeneity has a distinct, organized, pattern. This particular hallmark can now be used as a part of the strategy for developing rational therapies based on multiple sets of targetable antigens. [less ▲]

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See detailAdherence to Continuous Positive Airway Pressure (CPAP) Therapy
Deflandre, Eric ULg; Degey, Stéphanie; BONHOMME, Vincent ULg et al

in CHEST (2014, March), 145

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See detailCertificat d’université en tutorat à distance : une approche de formation isomorphique pour acquérir des compétences de e-tuteur
Denis, Brigitte ULg

in Tutorales (2014, March), 12

Depuis plus d'une dizaine d'années, de nombreux auteurs ont décrit les rôles des tuteurs dans les dispositifs de formation en ligne (Depover et al, 2011 ; Salmon, 2000). La "présence" et les interventions ... [more ▼]

Depuis plus d'une dizaine d'années, de nombreux auteurs ont décrit les rôles des tuteurs dans les dispositifs de formation en ligne (Depover et al, 2011 ; Salmon, 2000). La "présence" et les interventions de ces derniers s'avèrent un facteur important dans l'efficacité de tels dispositifs, qu'il s'agisse de maintien de la motivation des apprenants ou du processus d'apprentissage. La variété des méthodologies mises en œuvre dans les scénarios de formation (apprentissage collaboratif, coopératif, individuel...) entraînent des modalités d'interaction différentes entre e-tuteur et apprenants. Se basant sur les étapes de formation au e-tutorat décrites par Denis (2003), un processus original de formation de e-tuteurs est proposé afin de rencontrer la diversité et l'adéquation des profils à adopter selon le contexte considéré. Le scénario de formation au e-tutorat recourt au principe d'isomorphisme en pédagogie (Leclercq, 1998). Outre des apports théoriques relatifs à la problématique traitée et une approche réflexive sur cette dernière, les formés sont amenés à vivre différentes situations d'animation qui pourront (ou non) les inspirer dans leurs futures pratiques de tutorat à distance. Par ailleurs, la formation met l'accent sur le respect d'une triple concordance entre les compétences visées, les activités mises en place et les modalités d'évaluation. [less ▲]

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See detailPrognostic value of FDG PET/CT in liver transplantation for hepatocarcinoma
DETRY, Olivier ULg; Govaerts, L; BLETARD, Noëlla ULg et al

in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 08

AIM : FDG uptake has been shown to predict the outcome in large series of patients with hepatocarcinoma (HCC) in Asia, but few data are available regarding European populations. Our aim was to evaluate ... [more ▼]

AIM : FDG uptake has been shown to predict the outcome in large series of patients with hepatocarcinoma (HCC) in Asia, but few data are available regarding European populations. Our aim was to evaluate the prognostic value of pretreatment FDG PET-CT in patients treated by liver transplantation. Methods: We retrospectively analyzed the data of 27 patients (24 M and 3 W, mean age 58 ± 9 years). The mean follow-up was 26 ± 18 months (min 1 month, max 66 months). All patients had an FDG PET-CT before the transplantation. The FDG PET/CT was performed according to a standard clinical protocol: 4 MBqFDG/kg body weight, uptake 60 min., low-dose non-enhanced CT. We measured the SUVmax and SUVmean of the tumor and the normal liver. The tumor/liver activity ratios (RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors: MILAN, CLIP, OKUDA, TNM stage, alphafoetoprotein level, portal thrombosis, size of the largest nodule, tumor differentiation, microvascular invasion, underlying cirrhosis and liver function. Results : The DFS was 87.2% at 1y and 72.1% at 3y. The OS was 85.2% at 1y and 80.7% at 3y. According to an univariate Cox model, RSUVmax, RSUVmean and healthy liver were predictors of DFS and RSUVmax, RSUVmean, size of the largest nodule, CLIP, liver involvement>50%, and healthy liver predicted the OS. According to a multivariate Cox model, only RSUVmax predicted DFS and RSUVmax and liver involvement>50% predicted OS. An ROC analysis of the ratios showed that the 1.15 cut-off for RSUVmax was best for predicting both the DFS (Cox regression:HR 14.4, p=0.02) and OS (HR 5.6, p=0.049). The Kaplan-Meier curves and Logrank tests confirmed those results. Even though the MILAN criteria alone were not predictive, it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 relapsed. Conclusions: The RSUVmax is a strong prognostic factor for recurrence and death in patients with HCC treated by liver transplantation with a cut-off value of 1,15. further prospective studies should test whether the metabolic index should be systematically included in the preoperative assessment. [less ▲]

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See detailUsing micro-injection technique to assess fungal toxicity in mosquito control
Bawin, Thomas ULg; Boukraa, Slimane; Seye, Fawrou et al

in Communications in Agricultural and Applied Biological Sciences (2014, February 07), 79(1), 181-185

Topical application of insecticidal compounds allows directly exposing these substances on insect tissues and measuring their toxicity while ignoring many factors. However, this technique remains ... [more ▼]

Topical application of insecticidal compounds allows directly exposing these substances on insect tissues and measuring their toxicity while ignoring many factors. However, this technique remains difficult to apply on mosquito larvae considering their aquatic lifestyle. Micro-injection could be used for the direct deposition of toxic compounds in the larvae. Capillaries exhibiting an injection tip with an external diameter of 0.5 mm have been designed from silica tubes. For each treatment, a capillary is mounted on a pump connected to a flow rate regulator. Culex quinquefasciatus larvae were injected with 10^7 spores/ml of entomopathogenic fungi (Aspergillus clavatus, Metarhizium anisopliae, Metarhizium sp.). Mortalities were recorded daily during 72h. The distribution of spores stained with methylene blue and injected into the body of larvae was also observed according to the system described. Results showed that spores were distributed over the whole body. The injection of Aspergillus clavatus, Metarhizium anisopliae and Metarhizium sp spores induced corrected mortalities of 62%, 53% and 57% after 72h, and differed statistically from control groups. Finally, post-mortem emergences of filaments from dead larvae were observed in the case of the three fungal strains confirming spore viability. Injection of inactivated spores (or inert bodies of similar size) could help to reject the hypothesis of a response due to the presence of foreign bodies. [less ▲]

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See detailIMPLEMENTATION OF A METAL STRUCTURED PACKING IN A FUNGAL BIOFILM REACTOR FOR THE PRODUCTION OF A RECOMBINANT PROTEIN BY ASPERGILLUS ORYZAE
Zune, Quentin ULg; Delepierre, Anissa; Toye, Dominique ULg et al

in Communications in Agricultural and Applied Biological Sciences (2014, February 07)

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See detailPhysico-chemical properties and aroma profile of Acacia Honey produced in Romania
Madas, Mariana-Niculina ULg; Francis, Frédéric ULg; Marghitas, L.A. et al

in Communications in Agricultural and Applied Biological Sciences (2014, February 07), 79(1), 133-135

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See detailOrigin and Pulsation of Hot Subdwarfs
Randall, Suzanna K; Fontaine, Gilles; Charpinet, Stéphane et al

in Proceedings of the International Astronomical Union (2014, February), 301

We briefly introduce hot subdwarfs and their evolutionary status before discussing the different types of known pulsators in more detail. Currently, at least six apparently distinct types of variable are ... [more ▼]

We briefly introduce hot subdwarfs and their evolutionary status before discussing the different types of known pulsators in more detail. Currently, at least six apparently distinct types of variable are known among hot subdwarfs, encompassing p- as well as g-mode pulsators and objects in the Galactic field as well as in globular clusters. Most of the oscillations detected can be explained in terms of an iron opacity mechanism, and quantitative asteroseismology has been very successful for some of the pulsators. In addition to helping constrain possible evolutionary scenarios, studies focussing on stellar pulsations have also been used to infer planets and characterize the rotation of the host star. [less ▲]

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See detailPulsations in white dwarf stars
Fontaine, Gilles; Bergeron, Pierre; Brassard, Pierre et al

in Proceedings of the International Astronomical Union (2014, February), 301

We first present a brief description of the six distinct families of pulsating white dwarfs that are now known. These are all opacity-driven pulsators showing low- to mid-order, low-degree gravity modes ... [more ▼]

We first present a brief description of the six distinct families of pulsating white dwarfs that are now known. These are all opacity-driven pulsators showing low- to mid-order, low-degree gravity modes. We then discuss some recent highlights that have come up in the field of white dwarf asteroseismology. [less ▲]

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See detailG-mode trapping and period spacings in hot B subdwarf stars
Charpinet, Stéphane; Van Grootel, Valérie ULg; Brassard, Pierre et al

in Proceedings of the International Astronomical Union (2014, February), 301

Hot B subdwarfs (sdB) are hot and compact helium core burning stars of nearly half a solar mass that can develop pulsational instabilities driving acoustic and/or gravity modes. These evolved stars are ... [more ▼]

Hot B subdwarfs (sdB) are hot and compact helium core burning stars of nearly half a solar mass that can develop pulsational instabilities driving acoustic and/or gravity modes. These evolved stars are expected to be chemically stratified with an almost pure hydrogen envelope surrounding a helium mantle on top of a carbon/oxygen enriched core. However, the sdB stars pulsating in g-modes show regularities in their observed period distributions that, surprisingly (at first sight), are typical of the behavior of high order g-modes in chemically homogeneous (i.e., non-stratified) stars. This led to a claim that hot B subdwarfs could be much less chemically stratified than previously thought. Here, we reinvestigate trapping effects affecting g-modes in sdB stars. We show that standard stratified models of such stars can also produce nearly constant period spacings in the low frequency range similar to those found in g-mode spectra of sdB stars monitored with Kepler. [less ▲]

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See detailUse of automatic stapling device during castration to prevent (re)occurrence of inguinal hernia in horses with large vaginal rings.
Salciccia, Alexandra ULg; de la Rebière de Pouyade, Geoffroy ULg; Ponthier, Jérôme ULg et al

in Journal of Equine Veterinary Science (2014, January), 34(1), 99-100

(Re)ocurrence of inguinal hernia in case of very large vaginal rings may simply be prevented by closure of the vaginal tunic by TA staples during castration by inguinal approach. This method provides a ... [more ▼]

(Re)ocurrence of inguinal hernia in case of very large vaginal rings may simply be prevented by closure of the vaginal tunic by TA staples during castration by inguinal approach. This method provides a good resistance to internal pressure, appears to be safe, fast and easy to perform and may therefore be an interesting alternative to laparoscopic techniques when castration is considered. [less ▲]

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See detailEdging towards better accounting
Schumesch, Patrice ULg

in Accounting and Business Magazine of the Association of Certified Chartered Accountants (2014, January)

The ACCA's International Public Sector Conference explored the direction of public sector reporting, and rebuilding public trust through improved financial reporting. Other speakers included Carla Moordy ... [more ▼]

The ACCA's International Public Sector Conference explored the direction of public sector reporting, and rebuilding public trust through improved financial reporting. Other speakers included Carla Moordy of Monitory UK, Zinga Venner of the World Bank, and Professor Michael Parker of Henley Business School. [less ▲]

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See detailMigrations congolaises (RDC) en Belgique et postcolonialismes
Demart, Sarah ULg

in La lutte contre les discriminations au regard de l’histoire et de la mémoire coloniales : état des lieux (2014, January)

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See detailSperm Motility and Lactate production at different sperm concentrations
Ponthier, Jérôme ULg; De Tullio, Pascal ULg; Blommaert, Didier ULg et al

in Journal of Equine Veterinary Science (2014, January), 34(1), 75-76

Lactate production is associated with total spermatozoa concentration. It negatively affects preservation of total and progressive motility, showing an effect of by-products of anaerobic metabolism on ... [more ▼]

Lactate production is associated with total spermatozoa concentration. It negatively affects preservation of total and progressive motility, showing an effect of by-products of anaerobic metabolism on long-term storage. Moreover, our data show that non-progressive motile spermatozoa are highly associated to lactate concentration, and thus, anaerobic glycolysis. More studies are required to determine relative contributions of aerobiosis and anaerobiosis to spermatozoa motility under different storage conditions. [less ▲]

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See detailA Spatiotemporal Analysis of Membership: Formalizing the Space-Time Elements of Connection for Groups
Hallot, Pierre ULg; Stewart, Kathleen

in Proceedings of the AAG Annual Meeting (2014)

This research aims to formalize the spatiotemporal relationships of membership between individuals and the groups to which they belong. Specifically, we analyze how the membership to a community evolves ... [more ▼]

This research aims to formalize the spatiotemporal relationships of membership between individuals and the groups to which they belong. Specifically, we analyze how the membership to a community evolves over time considering past, present and future connections. The framework developed for this research is presented using an ontological approach. We demonstrate a specific domain ontology application for spatiotemporal membership using BFO2, an updated version of the Basic Formal Ontology. Key to this work is the representation of membership, modeled through different kinds of mereological relations possible with a group, for example, pre-member, active member, and alumni that capture how membership evolves and changes over time. The semantic web rule language (SWRL) is used to express the different spatiotemporal events that relate to membership and their consequences on membership such as subscription, graduation and reunion events. Mobility events are also included in the model. SWRL supports reasoning using the ontology and studying the evolution of membership between people and their various groups. We use the environment of a university community as an exemplar to develop and test the formalizations. However, the ideas are generalizable to a wide range of spatiotemporal domains, for example, these ideas hold for citizenship modeling or for consumers shopping at certain retail chains. The study of the evolution of membership connections between these entities and groups lends important insights for many different kinds of event planning. [less ▲]

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See detailRisk factors for falls among elderly nursing home residents: a 2-year prospective study
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Osteoporosis International (2014), 25(2), 36-37

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See detailImpact of bone marrow lesion on the progression of knee osteoarthritis in the Sekoia study
Parsons, C; Edwards, MH; Bruyère, Olivier ULg et al

in Osteoporosis International (2014), 25(2), 142

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See detailIm Labyrinth der eigenen Lebensgeschichte. Krankheit und Erzählen in Wilhelm Raabes "Holunderblüte" und Theodor Storms "Ein Bekenntnis"
Leyh, Valérie ULg

in Jahrbuch der Raabe-Gesellschaft (2014)

Les nouvelles "Holunderblüte" (1863) de Wilhelm Raabe et "Ein Bekenntnis" (1887) de Theodor Storm allient psychologie, maladie et narration. Les deux textes racontent l’histoire de médecins qui à la fin ... [more ▼]

Les nouvelles "Holunderblüte" (1863) de Wilhelm Raabe et "Ein Bekenntnis" (1887) de Theodor Storm allient psychologie, maladie et narration. Les deux textes racontent l’histoire de médecins qui à la fin de leur vie se questionnent sur leur propre responsabité dans un épisode du passé qui changea définitivement le cours de leur existence: la maladie et la mort de l’être qui leur était le plus cher (une jeune fille chez Raabe, l’épouse chez Storm). Par rapport aux études psychanalytiques très nombreuses dans la recherche sur Storm, cette étude souhaite montrer que la profondeur psychologique des textes doit être décrite par une analyse tenant compte du rôle anthropologique de la narration. Au niveau des narrateurs, la narration a ainsi une valeur curative pour ces deux médecins souffrant de sentiments de culpabilité et souhaitant retracer leur vie comme un sentier linéaire, cohérent et imbibé de sens. Les fonctions anthropologiques de la narration (production de sens, réduction de la contingence et de l’angoisse) auxquelles font appel ces individus sont toutefois relativisées par les textes eux-mêmes qui par leur forme et par le motif du labyrinthe évoquent l’aléatoire, la contingence et l’absence de sens. [less ▲]

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See detailComparison of continuous background in-situ and column integrated CO2 observations at Jungfraujoch with an urban site in the city of Bern
Schibig, Michael; Leuenberger, Markus; Nyfeler, Peter et al

in Geophysical Research Abstracts (2014), 16

A six and a half year (January 2005 to May 2011) comparison of CO2 concentration observations has been performed at Jungfraujoch, Switzerland and the city of Bern using two different measurement ... [more ▼]

A six and a half year (January 2005 to May 2011) comparison of CO2 concentration observations has been performed at Jungfraujoch, Switzerland and the city of Bern using two different measurement techniques run by the University of Bern (UBE) and the University of Liege (UL). The UBE systems at Jungfraujoch and Bern are both combined systems for atmospheric oxygen and CO2 measurements. The cryogenically dried air is analysed for CO2 with a Maihak analyser based on the broad-band infrared absorption technique. The measurement frequency is every second but the final reported data are averages of six minute periods. UL is measuring the solar infrared spectrum since 1950 at Jungfraujoch. On its way through the atmosphere, the solar spectrum is modulated depending on the abundant gas species and their amount in the column. Since some gases like CO2 absorb the solar infrared radiation at particular wavelengths and the extinction is proportional to the gas concentration, it is possible to determine the gas concentration in the column above the sensor. At the conference, we will present the three observational records for the six and a half year period. The results show for all three records a distinct, but different seasonality. The seasonalities of the UL and UBE record at Jungfraujoch are lower than the seasonality in the city of Bern, i.e. 4.5 ppm per year and 9 ppm per year for the column and the in- situ record respectively, whereas the seasonality in the city of Bern is 31 ppm per year. Also the maxima and minima of the Jungfraujoch measurements are delayed by several weeks compared to the measurements in the city of Bern. The annual increase of the CO2 concentration of the UBE and UL records of Jungfraujoch are in good agreement with 1.94 ppm per year and 1.90 ppm per year, respectively. The annual increase of the CO2 concentration at the urban site is a bit higher at 2.01 ppm per year. [less ▲]

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See detailEconomic evaluation of an osteoporosis screening campaign: using FRAX as a prescreening tool
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2014), 25(2), 38-39

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See detailPrognostic factors of death among nursing homes residents followed prospectively for a period of 2 years
Buckinx, Fanny ULg; Slomian, Justine ULg; Maquet, Didier ULg et al

in Osteoporosis International (2014), 25(2), 121-122

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See detailDétection de l'hémoglobinurie paroxystique nocturne par cytométrie en flux : Validation
Louis, Céline; FOGUENNE, Jacques ULg; KEUTGENS, Aurore ULg et al

in Revue de l'Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2014), 41(3), 240

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See detailImpact of bone marrow lesion on the progression of knee osteoarthritis in the SEKOIA study
Parsons, C; Edwards, MH; Bruyère, Olivier ULg et al

in Rheumatology (2014), 53(1), 130

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See detailEfficient finite element assembly of high order Whitney forms
Marsic, Nicolas ULg; Geuzaine, Christophe ULg

in IET Conference Proceedings (2014)

This paper presents an efficient method for the finite element assembly of high order Whitney elements. We start by reviewing the classical assembly technique and by highlighting the most time consuming ... [more ▼]

This paper presents an efficient method for the finite element assembly of high order Whitney elements. We start by reviewing the classical assembly technique and by highlighting the most time consuming part. Then, we show how this classical approach can be reformulated into a computationally efficient matrix - matrix product. We also address the problem of the basis orientation by considering more than one reference space. We conclude by presenting numerical results on a wave guide problem. [less ▲]

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See detailFacteurs pronostiques de décès chez des sujets résidant en maison de repos suivis d'une manière prospective pendant une période de 2 ans
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(1), 73-74

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See detailGalectins in cancer: jacks of all trades
Heusschen, Roy ULg; Schulkens, Iris; Muller, Joséphine ULg et al

in International Journal of Molecular Medicine (2014)

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See detailMicrostructures and Mechanical Properties of Stainless Steel AISI 316L Processed by Selective Laser Melting
Mertens, Anne ULg; Reginster, Sylvie ULg; Contrepois, Quentin et al

in Materials Science Forum (2014), 783-786 (2014)

In this study, samples of stainless steel AISI 316L have been processed by selective laser melting, a layer-by-layer near-net-shape process allowing for an economic production of complex parts. The ... [more ▼]

In this study, samples of stainless steel AISI 316L have been processed by selective laser melting, a layer-by-layer near-net-shape process allowing for an economic production of complex parts. The resulting microstructures have been characterised in details in order to reach a better understanding of the solidification and consolidation processes. The influence of the processing parameters on the mechanical properties was investigated by means of uniaxial tensile testing performed on samples produced with different main orientations with respect to the building direction. A strong anisotropy of the mechanical behaviour was thus interpreted in relation with the microstructures and the processing conditions. [less ▲]

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See detailAssociation between lean mass and hip bone mineral density
Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg; Slomian, Justine ULg et al

in Arthritis and Rheumatism (2014), 66(11), 95

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See detailToward redesigning the relationship between farming systems and biodiversity conservation
Brédart, David ULg; Denayer, Dorothée ULg; Mormont, Marc ULg

in Proceedings of the 11th European IFSA Symposium. Farming systems facing global challenges: capacities and strategies. (2014)

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See detailAn interaction map for HTLV-1 Tax and PDZ-containing proteins
Blibek, Karim ULg; Rambout, Xavier ULg; Beaufays, Jérome et al

in Retrovirology (2014), 11

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See detailQuality of life benefits of knee arthroplasty for osteoarthritis
NEUPREZ, Audrey ULg; François, Garance ULg; KURTH, William ULg et al

in Osteoporosis International (2014), 25(2), 40

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See detailQuels facteurs sociodémographiques influencent l'attitude des médecins généralistes envers la prévention ?
Vanmeerbeek, Marc ULg; Donneau, Anne-Françoise ULg; Monseur, Christian ULg

in Revue Médicale de Bruxelles (2014), 35(3 (Suppl)), 6

Objectifs En Belgique, les mesures de prévention médicalisées restent inéquitablement distribuées dans plusieurs domaines (vaccins, dépistages, conseil cardio-vasculaire, etc.). Une recherche antérieure ... [more ▼]

Objectifs En Belgique, les mesures de prévention médicalisées restent inéquitablement distribuées dans plusieurs domaines (vaccins, dépistages, conseil cardio-vasculaire, etc.). Une recherche antérieure au moyen d’une échelle d’attitude a mis en évidence trois facteurs pouvant modeler l’attitude des médecins généralistes (MG) envers la prévention : 1. Evaluation de pratique. 2. Sentiment de responsabilité envers la santé des patients. 3. Compétences professionnelles particulières (CPP) : références scientifiques, positionnement dans le système de soins, délégation de tâches à des paramédicaux. Cette étude a cherché à établir des profils de MG par rapport à la prévention, en croisant les scores sur ces trois facteurs et les variables sociodémographiques. Méthode Les réponses des 457 MG répondants à l’échelle d’attitude ont été soumis à des analyses multivariées, en prenant comme variables dépendantes les scores obtenus sur les trois facteurs, et comme variables indépendantes l’ancienneté, le sexe, la langue, le lieu de pratique, le travail dans un centre de prévention (ONE, planning, PSE), le type de pratique (solo ou divers types d’association). Résultats Le type de pratique est le seul déterminant qui influence les 3 facteurs, avec un gradient des pratiques solo vers les maisons médicales, en passant par les associations mono- puis pluridisciplinaires. Les MG ayant moins de 20 ans de pratique ont de meilleurs scores en évaluation et CPP. Les hommes ont de meilleurs scores en évaluation, et les pratiques urbaines se distinguent en CPP. La langue influence tantôt dans un sens tantôt dans l’autre. Il n’y a pas d’influence du fait de travailler dans un centre de prévention. Conclusion Une diffusion plus large et équitable des actes préventifs passe par la prise en compte de facteurs personnels et organisationnels propres aux MG. Les associations pluridisciplinaires semblent mieux préparées pour atteindre cet objectif. [less ▲]

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See detailPercentage of women achieving non-osteoporotic BMD T-scores at the spine and hip over 8 years of denosumab treatment
Ferrari, S; Libanati, C; Lin, CJF et al

in Arthritis and Rheumatism (2014), 66(11), 986-987

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See detailOdanacatib anti-fracture efficacy and safety in postmenopausal women with osteoporosis: results from the phase III long-term odanacatib fracture trial
McClung, MR; Langdahl, B; Papapoulos, S et al

in Arthritis and Rheumatism (2014), 66(11), 987

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See detailEvaluation du nombre de résidents en maison de retraite médicalisée bénéficiant d'une supplémentation en vitamine D
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Cavalier, Etienne ULg et al

in Cahiers de l'Année Gérontologique (Les) (2014), 2(23), 207-63

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See detailEfficient finite element assembly of high order Whitney forms
Marsic, Nicolas ULg; Geuzaine, Christophe ULg

in IET Conference Proceedings (2014)

This paper presents an efficient method for the finite element assembly of high order Whitney elements. We start by reviewing the classical assembly technique and by highlighting the most time consuming ... [more ▼]

This paper presents an efficient method for the finite element assembly of high order Whitney elements. We start by reviewing the classical assembly technique and by highlighting the most time consuming part. Then, we show how this classical approach can be reformulated into a computationally efficient matrix - matrix product. We also address the problem of the basis orientation by considering more than one reference space. We conclude by presenting numerical results on a wave guide problem. [less ▲]

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See detailOdanacatib anti-fracture efficacy and safety in postmenopausal women with osteoporosis: results from the phase III long-term odanacatib fracture trial
McClung, MR; Langdahl, B; Papapoulos, S et al

in Osteoporosis International (2014), 25(5), 573-575

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See detailVitamine D et sujet âgé
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(1), 5-6

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See detailImplication des troubles métaboliques dans la progression radiologique de la gonarthrose : analyse post-hoc issue de l'essai randomisé SEKOIA
Eymard, F; Parsons, C; Edwards, M et al

in Revue du Rhumatisme (2014), 81(1), 92

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See detailDélires et Hallucinations : Echelle transdiagnostique d’auto-évaluation.
Beaupain, Margaux; Thirion, Julie; Wagener, Aurélie ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2014), 19(3), 72

Introduction : Les délires et les hallucinations sont des symptômes majeurs présents chez 80% des personnes souffrant d’un trouble psychotique (e.g., bipolaire, schizophrène). Cependant, ces phénomènes ... [more ▼]

Introduction : Les délires et les hallucinations sont des symptômes majeurs présents chez 80% des personnes souffrant d’un trouble psychotique (e.g., bipolaire, schizophrène). Cependant, ces phénomènes sont également présents dans d’autres troubles psychiatriques (e.g., troubles anxieux, dépression) et chez 8% des individus tout venants (Linscott & Van Os, 2012) suggérant l’importance de les évaluer. D’après la littérature, les populations cliniques et non-cliniques se distinguent d’avantage à travers différentes dimensions telles que la détresse, la conviction et le contenu que par la fréquence (Lincoln, 2007). Cependant, les évaluations existantes se centrent principalement sur la fréquence des phénomènes, ce qui laisse beaucoup d’informations cliniques de côté. De plus, elles ne sont que rarement basées sur une approche en continuum permettant d’appréhender la complexité et l’hétérogénéité des phénomènes (allant des perceptions aberrantes jusqu’aux délires et hallucinations). Enfin, ce sont souvent des hétéroévaluations qui sont chronophages et requièrent du personnel qualifié alors que certaines études suggèrent une bonne validité des autoévaluations de ces phénomènes (Se Hyun et al., 2010). Afin de pallier ces limites, nous avons développé une échelle transdiagnostique d’auto-évaluation des idées délirantes et hallucinations en se basant sur une approche en continuum. Méthode : Une revue de la littérature sur les caractéristiques et outils d’évaluations des idées délirantes et des hallucinations a été réalisée. Vingt-quatre items parmi les plus discriminants ont été sélectionnés et adaptés. Pour chaque item, huit dimensions ont été sélectionnées : fréquence, détresse, interférence, conviction, état de conscience, contenu positif VS négatif, agréabilité et attribution interne VS externe. Les individus répondent d’abord à la fréquence sur une échelle de type Likert en 5 points (« Oui, ça m’arrive souvent » à « Non, ça ne m’est jamais arrivé »). Si la réponse est positive, les sept autres dimensions sont évaluées via une échelle visuelle analogique de 0 à 10. Perspectives: L’échelle est actuellement en cours de validation. Elle sera pré-testée auprès d’étudiants avant d’être validée auprès de populations cliniques et non-cliniques. A long terme, cette échelle transdiagnostique d’auto-évaluation pourrait être utilisée en clinique comme un outil favorisant une meilleure prise en charge de ces symptômes et comme un nouvel outil de recherche. [less ▲]

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See detailWhich measurement strategies to improve spatial erosion and deposition patterns modelling?
Pineux, Nathalie ULg; Maugnard, Alexandre; Swerts, Gilles ULg et al

in Geophysical Research Abstracts (2014), 16

Validation of the erosion models requires field data. To date, many authors continue to highlight the paucity of accurate field observations and long-term enough studies. The fields observations are often ... [more ▼]

Validation of the erosion models requires field data. To date, many authors continue to highlight the paucity of accurate field observations and long-term enough studies. The fields observations are often put aside because these measures are difficult to obtain: weighty experimental devices, climatic dependence, . . . Hence the models are evolving and propose refined calculation procedures including for instance the calculation of landscape evolution. The need of field data therefore increases and new measuring strategies should arise. In the centre of Belgium we choose an agricultural watershed quite representative of the local context. It covers 124 ha of loamy soil with more than 90% of arable land and a weak proportion of forest and artificial lands. The slope ranges between 0 and 9%. Instrumentation on the watershed includes meteorological observations and discharge measurement coupled with water sampling at different outlets. The weather data (radiation, temperature, wind velocity, relative humidity and rainfall) and discharge measurement (comparison between Doppler and pressure sensors) will allow us to model the hydrological behaviour of the catchment. Rainfall readings (tipping buckets) are completed with erosivity readings (disdrometer). Erosivity, together with soil data, land use and agricultural practices observations on field, will be used as entry in the Landsoil model. The sediment samplings at 3 points in the catchment will give an insight of the sediment delivery of 3 subcatchments. The Landsoil model calculates the evolution of the DTM through time. This cannot be compared to measurements at the outlet and requires further data collection. Older elevation data and/or archaeological data are a possible source of information even if their precision remains scarce in our context. 1950’s soil surveys are on the contrary really informative since they detail the horizons depth in a spatial way and can be compared to new observation across the watershed. Coupled with unmanned aerial system, they should allow us to test the model performances and improve our knowledge of the spatial patterns of erosion and deposition. [less ▲]

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