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See detailÉVOLUTION DE LA TENEUR EN EAU LE LONG D’UNE TOPOSEQUENCE FORESTIERE ARGILO-LIMONEUSE
Deraedt, Deborah ULg; Colinet, Gilles ULg; Degré, Aurore ULg

in Milieux Poreux et Transferts Hydriques (in press)

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and ... [more ▼]

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and steep slope. The soil water content is monitored at several positions on the toposequence and at different depth. During rain events, peak in soil water content are observed in different depth depending on the position along the toposequence. [less ▲]

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See detailMesurer les distances entre des textes pré-carolingiens linguistiquement non-normés: le cas de la Passion de sainte Marine
Goullet, Monique; Philippart de Foy, Caroline ULg

in Etudes Classiques (Namur, Belgium) (in press)

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See detailArrêt(s) sur image(s) : usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailLa ceramica della Schola del Traiano a Ostia Antica
Deru, Xavier ULg; Desbat, Armand; Dienst, Simon ULg et al

in Forum Romanum Belgicum (in press)

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See detailModels of rotating stars constrained by asteroseismic measurements of red giants
Eggenberger, P.; Lagarde, N.; Miglio, A. et al

in Astronomische Nachrichten (in press)

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and ... [more ▼]

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and internal properties of these stars. In particular, core rotation rates have been obtained for red-giant stars, which is of prime importance to progress in the modelling of the dynamical processes at work in stellar interiors. In this presentation, we discuss which constraints can be brought by these asteroseismic measurements on stellar models that include rotational effects. Similarly to the solar case, we show that an efficient mechanism is required for the transport of angular momentum in the radiative zones of red giants. The efficiency of this transport process can be determined by asteroseismic observations of red-giant stars. [less ▲]

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See detailAntonymic co-presence: overview of the syntactic patterns model
Steffens, Marie ULg

in Studies van de BKL - Travaux du CBL - Papers of the LSB (in press), 10

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See detailMinimalisme / musiques populaires : un cas pour la théorie de l’acteur-réseau
Levaux, Christophe ULg

in Musimédiane (in press), 9

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See detailTwo-loop-induced neutrino masses: A model-independent perspective
Aristizabal Sierra, Diego ULg

in PoS - Proceedings of Science (in press)

We disucuss Majorana neutrino mass generation mechanisms at the two-loop order. After briefly reviewing the systematic classification of one-loop realizations, we then focus on a general two-loop ... [more ▼]

We disucuss Majorana neutrino mass generation mechanisms at the two-loop order. After briefly reviewing the systematic classification of one-loop realizations, we then focus on a general two-loop classification scheme which provides a model-independent catalog for neutrino mass models at the two-loop order [less ▲]

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See detailChronos et la clé du temps
Désert, Jean-Benoît ULg; Charon, valérie; Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (in press), 15(15), 79-85

L’argument de ce XLème Colloque des Hôpitaux de jour psychiatriques nous a plongés dans un abîme de questionnements théoriques et pratiques. Défiés par cette immersion dans les tréfonds du modèle, nous ... [more ▼]

L’argument de ce XLème Colloque des Hôpitaux de jour psychiatriques nous a plongés dans un abîme de questionnements théoriques et pratiques. Défiés par cette immersion dans les tréfonds du modèle, nous avons choisi de nous accrocher aux fondements de notre univers. La mythologie grecque sera donc notre source d’inspiration en mettant un dieu antique à notre disposition. Chronos sera notre guide dans un périple réflexif soumettant nos théories et notre pratique à l’épreuve du temps. Le récit de la conception d’un atelier thérapeutique, l’atelier « Art & Temps », sera notre fil d’Ariane dans notre tentative de symboliser notre pratique thérapeutique quotidienne et ses enjeux. Par la suite, l’exposé d’un cas clinique concrétisera un raisonnement théorique visant à situer notre modèle de prise en charge dans le réseau psychiatrique global. [less ▲]

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See detailL'aménagement transsexuel comme solution à l'adolescence
BURDOT, Frédéric ULg; Malchair, Alain ULg

in Revue Enfance et Adolescence (in press)

L’aménagement transsexuel comme solution à l’adolescence La transsexualité est souvent banalisée par les médias, séduits par l’idée facile à vendre d’une âme sexuée, donc du drame de la possible ... [more ▼]

L’aménagement transsexuel comme solution à l’adolescence La transsexualité est souvent banalisée par les médias, séduits par l’idée facile à vendre d’une âme sexuée, donc du drame de la possible inadéquation entre le sexe psychique et le sexe corporel. L’observation clinique rigoureuse de son élaboration plaide cependant pour une architecture complexe, résultant d’une dynamique subtile entre le psychisme, l’histoire et l’environnement. En effet, dans l’analyse d’un cas clinique, nous constatons que, face au risque de l’effondrement identitaire d’une structure fragile le Moi tente de se renforcer par l’organisation de mécanismes de défense qui élabore une nouvelle identité étayée sur un physique transité vers l’autre sexe. Si l’on analyse les interactions précoces sous l’angle de la formation de l’identité sexuelle, le noyau « genré » du Moi peut subir une double attaque, par manque d’identification au même et par attaque mortifère du différent. Le Moi se trouve ainsi délié et persécuté par des objets partiels ou peu introjectés. A l’adolescence, moment potentiellement traumatique de la sexuation, le jeune se trouve confronté à l’interrogation sur son identité sexuelle, et lorsque le noyau « genré » s’est précisément trouvé fragilisé, l’angoisse surgit, avec le risque d’une bascule psychotique. Dans ces cas extrêmes, la recherche d’une nouvelle enveloppe, remodelage de la peau, permet de contenir l’éclosion du courant psychotique grâce à la disponibilité permanente de l’incorporation du différent, identification certes coûteuse en ressources mais peut-être, à même d’éviter l’effondrement narcissique complet. [less ▲]

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See detailLes actes notariés : des sources négligées dans l'étude des conflits quotidiens des populations du XVIIIe siècle à Liège
Drécourt, Aurore ULg

in Annales de l'Est (in press)

Insults, gossip, and slander are the origin of many conflicts during the Ancien Régime. They are used to hurt someone’s honour or reputation, which are essential values to keeping good relationships in ... [more ▼]

Insults, gossip, and slander are the origin of many conflicts during the Ancien Régime. They are used to hurt someone’s honour or reputation, which are essential values to keeping good relationships in society. People need to defend their honour when they are injured. They can seek reparations by taking legal action or opting for infrajudicial practices, such as contacting a notary. This possibility has attracted too little attention from historians whereas notarial records are a massive source of information related to conflicts affecting people's daily lives. Indeed, during the eighteenth century, inhabitants of Liège contacted a notary in order to find an agreement, clear their name of an insult, or to write their version of an aggression. [less ▲]

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See detailBiolaw and dual use dilemma: the freedom of scientific research in relationship with traditional and emerging sciences and technologies
Colussi, Ilaria Anna ULg

in International Journal of Biolaw (in press)

Science and technology require an intervention by the law, and law is called upon to intervene in front of their evolution, and to look for proper solutions of governance and rational responses to their ... [more ▼]

Science and technology require an intervention by the law, and law is called upon to intervene in front of their evolution, and to look for proper solutions of governance and rational responses to their risks. One of the main issues to be investigated from the legal viewpoint is represented by the ‘dual-use dilemma’ that arises both in ‘traditional’ and new areas of techno-sciences. Indeed, any kind of research has the potential to be used both for bad as well as for good purposes. Therefore, it is important to reflect upon the ways to control possibly dangerous research without preventing the progress from going further. Such ‘dual-use dilemma’, then, entails the study of one of the fundamental freedoms in the biolaw area: the freedom of scientific research, its limits, and relationship with other rights/needs/freedoms (such the need of security). This work focuses on two areas of the techno-scientific world. One is more ‘traditional’, i.e. nuclear science, in whose context the reflections on ‘dual-use’ were born and developed, and the other one is a new emerging technology, which is synthetic biology. The aim is to understand how the freedom of scientific research could be shaped in relationship with other rights/needs/interests for dealing with ‘dual-use’ issues in the aforementioned areas of science and technology. [less ▲]

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See detailRisques et périls d'opposer "Langue de culture" et "Langue de service"
Defays, Jean-Marc ULg

in Cahiers de l’ASDIFLE (in press), 27

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See detailValidated ready-to-use GC-MS/MS method for dioxin analysis in food and feed following the new EU Regulations
L'Homme, Benjamin ULg; Sandy, Chris; Scholl, Georges ULg et al

in Organohalogen Compounds (in press)

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See detailsynthéticité et intuition en mathématiques contemporaines : Kant au-delà de Kant
Mazurkiewicz, Stany ULg

in Eikasia. Revista de Filosofia. (in press)

Ce texte entend réévaluer l'idée de "pure synthèse intellectuelle" que l'on trouve chez Kant. Celle-ci cadre avec la pratique mathématique et métamathématique postérieure à Kant. Elle permet de dépasser l ... [more ▼]

Ce texte entend réévaluer l'idée de "pure synthèse intellectuelle" que l'on trouve chez Kant. Celle-ci cadre avec la pratique mathématique et métamathématique postérieure à Kant. Elle permet de dépasser l'alternative entre l'intuitionnisme développé dans la Critique de la raison pure et la fondation de la mathématique sur une logique formelle analytique. Je montre que cette idée convient à Bolzano et à Dedekind, dont je soutiens que les projets sont irréductibles à du logicisme et qui sont dès lors bien plus "kantiens" qu'il n'y paraît. [less ▲]

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See detailEn-deçà du langage : Communauté et historicité de l’antéprédicatif selon Heidegger
Zincq, Aurélien ULg

in Bulletin d'Analyse Phénoménologique (in press)

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See detailOn the Elaboration of Metal-Ceramic Composite Coatings by Laser Cladding
Mertens, Anne ULg; L'Hoest, Thibaut; Magnien, Julien et al

in Materials Science Forum (in press)

This paper reports on a preliminary investigation into the elaboration, by the additive process known as laser cladding, of composite coatings with a matrix of stainless steel 316L reinforced with varying ... [more ▼]

This paper reports on a preliminary investigation into the elaboration, by the additive process known as laser cladding, of composite coatings with a matrix of stainless steel 316L reinforced with varying contents of tungsten (WC) or silicon carbides (SiC) particles. Laser cladding is characterised by ultra-fast solidification and cooling rates, thus giving rise to ultra-fine out-of-equilibrium microstructures and potentially enhanced mechanical properties. Both types of composite coatings – i.e. with SiC or WC ‒ are compared in terms of their microstructures and hardness. Special attention is given to the dissolution of the carbides particles and to interfacial reactions taking place between the particles and the metallic matrix. [less ▲]

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See detailL’emblématique de Louise de Savoie
Fagnart, Laure ULg; Girault, Pierre-Gilles

in Armas e Troféus. Rivista de Historia, Heraldica, Genealogia (in press)

Durant cette communication, à la suite des travaux d'Anne-Marie Lecocq (1987), nous sommes revenus sur le discours héraldique de la comtesse et duchesse d'Angoulême, Louise de Savoie, l'influente mère de ... [more ▼]

Durant cette communication, à la suite des travaux d'Anne-Marie Lecocq (1987), nous sommes revenus sur le discours héraldique de la comtesse et duchesse d'Angoulême, Louise de Savoie, l'influente mère de François Ier. Nous avons présenté et explicité ses devises favorites, à savoir la cordelière, qui évoque autant le nœud de Savoie que la cordelière franciscaine, le vol, sans doute choisi puisque l’aile évoque le L de Louise par homophonie, le bouquet de lis ou le cygne « navré », mais aussi les écus et les monogrammes qui lui sont associés et qui ponctuent enluminures, tapisseries, bas-reliefs et éléments sculptés de l’architecture. Notre intention a été de montrer d’une part comment Louise de Savoie manifeste, par l’intermédiaire de ces signes emblématiques, son identité et son pouvoir, d’autre part comment elle construit, par leur biais, un patrimoine, mental, susceptible de renforcer son clan et ses héritiers. [less ▲]

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See detailRadiative Origin of Majorana Neutrino Masses
Aristizabal Sierra, Diego ULg

in PoS - Proceedings of Science (in press)

We discuss raditiative-induced neutrino mass mechanisms. We first briefly discuss systematic one-loop level classifications, and then discuss two-loop classification schemes based on a diagrammatic ... [more ▼]

We discuss raditiative-induced neutrino mass mechanisms. We first briefly discuss systematic one-loop level classifications, and then discuss two-loop classification schemes based on a diagrammatic decomposition of the Weinberg operator. We point out that both, the one and two-loop order systematic sorting provides an exhaustive guide for radiative neutrino mass models. [less ▲]

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See detailQuatre configurations pour créer une dynamique interactive entre formation et recherche Expériences dans le domaine de la formation des professionnels de la santé
Faulx, Daniel ULg; Burlet, Géraldine ULg; Bernard, Nicolas ULg et al

in Recherches Qualitatives (in press)

Dans cette contribution, nous nous penchons sur la possibilité de créer une dynamique interactive entre intervention sur le terrain et recherche scientifique dans le domaine de la formation. Les terrains ... [more ▼]

Dans cette contribution, nous nous penchons sur la possibilité de créer une dynamique interactive entre intervention sur le terrain et recherche scientifique dans le domaine de la formation. Les terrains d’application se situent tous ici dans le domaine de la santé. Nous présentons quatre configurations d’une telle complémentarité. Chacune d’entre elles représente une articulation différente entre le but de développement des participants et celui de production de savoirs scientifiques. Dans le premier cas, une démarche de recherche est entreprise en amont de la conception d’une formation. La deuxième configuration illustre une recherche scientifique appliquée à un dispositif d’intervention existant et qui vient en retour en modifier la logique. Pour la troisième, il s’agit d’une articulation continue entre recherche et formation s’alimentant mutuellement dans une logique de recherche-action. Enfin, la quatrième partie se penche sur trois dispositifs pédagogiques dont la caractéristique est de combiner des intentions formatives avec des préoccupations de recherche [less ▲]

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See detailEVALUATION OF FISH EXPOSURE TO POP-LIKE (ORGANOTIN) COMPOUNDS IN SEPETIBA BAY (RIO DE JANEIRO STATE, BRAZIL) THROUGH HEPATIC TOTAL TIN CONCENTRATIONS
Paiva, TC; Schilithz, PF; Bisi, TL et al

in Organohalogen Compounds (2016, August)

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See detailUsing NDACC column measurements of carbonyl sulfide to estimate its sources and sinks
Wang; Marshall, J; Palm, M et al

in Geophysical Research Abstracts (2016, April 19), 18

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

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See detailEfficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Reginster, Jean-Yves ULg

in Osteoporosis International (2016, April), 27(supplement 1), 65

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See detailIs isokinetic exercise dangerous for the heart?
Le Goff, Caroline ULg; Kaux, Jean-François ULg; Cavalier, Etienne ULg et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(suppl. 1 No. 2), 457

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in ... [more ▼]

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. PURPOSE: Our study aimed to observe the cardiovascular impact (by biological point of view) of maximal intense isokinetic eccentric and concentric protocols performed by a population of sedentary young men. METHOD: Resting (T0) and post-exercise (just after (T1), 3 hours (T2) and 24 hours after the exercise (T3)) blood samples were taken in 2 populations of young sedentary men: 12 subjects (22.5±1.15 yo) for the eccentric protocol and 18 subjects (22.4±2.6 yo) for the concentric protocol. These subjects performed an intense maximal isokinetic exercise of the quadriceps muscles involving 30 knee flexions–extensions for each leg. We evaluated markers of cardiovascular risk (highly sensitive troponin T (hs-TnT), N-Terminal Brain natriuretic peptide (NT-proBNP), myoglobin (MYO)), of inflammation (highly sensitive C-reactive protein (hsCRP)), muscle damage (creatine kinase (CK)) and of oxidative stress (myeloperoxidase (MPO), lipidic peroxides (POXL), reduced (GSH) and oxidised glutathione (GSSG)). Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: All the physiological parameters measured presented statistically significant changes. For the eccentric exercise, no significant modification in cardiac (NT-proBNP, hs-TNT) and inflammation (hsCRP) biomarkers was observed. However, a significant increase for CK (T3), MYO (T2), MPO (T1), POXL (T1), GSSG (T3) and ratio GSH/GSSG (T2-T3) was shown. For the concentric exercise, the results showed significant increases for the CK (T1-T2-T3), MYO (T1-T2), GSH/GSSG (T1). Evolutionary trends were also observed for the following biomarkers: NT-proBNP (T1-T2-T3), MPO (T2), and GSSG (T4). DISCUSSION and CONCLUSIONS: No modification in cardiac biomarkers was observed after the maximal eccentric isokinetic exercise but some variations can be observed for these biomarkers after the concentric exercise. However, these changes do not exceed the reference values in healthy subjects. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. Nevertheless, a significant level of oxidative stress was induced by both exercises. [less ▲]

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See detailEfficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Rannou, F.; Maheu; Reginster, Jean-Yves ULg

in Osteoporosis International (2016, April), 27(supplement 1), 66

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See detailOsteoarthritic sclerotic subchondral osteoblasts secreted elevated concentration of fibulin-3 fragments in vitro
Sanchez, Christelle ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 83

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See detailEffectiveness of High Intensity Radial Shock Wave Therapy in The Treatment of Chronic Plantar Fasciitis
Demoulin, Christophe ULg; Vanderthommen, Marc ULg; Fromm, Aurélien et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(Suppl. 1 No. 2), 733

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain ... [more ▼]

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain, function and pressure pain threshold in patients with chronicplantar fasciitis (PF). Materials and Methods: Patients with a diagnosis of chronic (pain lasting for more than 3 months) uni- or bilateral PF with a history of failed conservative treatment were included. After a 6-week control period during which no treatment occurred, a 2-week treatment period followed by a three weeks of rest (cicatrization phase) was provided. The treatment period consisted of three radial ESWT sessions (2000 impulses of 10 Hz frequency per session with an energy flux density of 0,275mJ/mm2) separated by a one-weekinterval. Patient assessments (pain intensity, foot function and pressure pain threshold (PPT) at the site of maximum local tenderness disability) were conducted at baseline, after the 6-week control phase (pre-treatment) and at the end of the cicatrization phase (post-treatment). Results: Thirty patients (19 women (63.3%)) with chronic PF and a mean age of 51.9±11 years were included in the present study. No drop-out occurred throughout the study period. No changes were observed at the pre-treatment assessment session except for pain intensity which decreased slightly but significantly (P<0.05). At the post-treatment session, highly significant (P<0.001) and clinically meaningful changes occurred for pain intensity (-34%), foot function score (-60%) and PPT (+68%). Conclusions: The present study suggests that high dose radial ESWT is a feasible and effective way to quickly and significantly decrease pain and disability in most patients with chronic PF. [less ▲]

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See detailGood prognosis factors after a platelet rich plasma (PRP) injection for tendinopathies ?
Kaux, Jean-François ULg; Sancerne, Audrey; Libertiaux, Vincent ULg

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(suppl. 1 No. 2), 251

Introduction : Platelet-rich plasma injections are a recent treatment for chronic tendinopathies. However, this theraeutic remains controversed in litterature. Up to now, there is no prognosis factors ... [more ▼]

Introduction : Platelet-rich plasma injections are a recent treatment for chronic tendinopathies. However, this theraeutic remains controversed in litterature. Up to now, there is no prognosis factors identified to predict a good evolution after injection of PRP. Purpose: The aims of this study were to evaluate the effect of PRP injection followed by a standardized reeducation protocol among patients suffering from different tendinopathies and to determine the good prognosis factors, if any. Methods : 51 patients suffering from different tendinopathies and refractory to conventional physiotherapy were treated with a PRP injection. Prior to the injection, a blood sample was drawn and some biological parameters (glycemia, cholesterol level, …). A pain assessment was then made using a visual analog scale (VAS) and a pressure algometer. The same assessment was carried out after 6 weeks and 12 weeks when possible. Results : There is an overall significant improvement VAS score at the end of the 12 weeks follow- up. However, no correlation was found between the evolution of the clinical scores and the biological parameters measured. Discussion and Conclusions : A PRP injection followed by a program of eccentric rehabilitation positively affects the algo-functional scores of patients with tendinopathie who were refractory to conventional physiotherapy, whatever their initial biological parameters. [less ▲]

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See detailAge-standardized quality of life after hip or knee arthoplasty.
Neuprez, Audrey ULg; KURTH, William ULg; THIRION, Thierry ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 541-542

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See detailrelationship between total hip BMD T-score and incidence of nonvertebral fracture with up to 10 years of Denosumab (DMAB) treatment
Ferrari, S.; ADAMI, S.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 49-50

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See detailThe future prevalence of sarcopenia in Europe
Ethgen, Olivier ULg; Tchoconte, C.; Beaudart, Charlotte ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 53-54

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See detailA randomized double-blind study of Denosumab (DMAB) compared with Zoledronic acid (ZOL) in postmenopausal women with osteoporosis previously treated with oral bisphosphonates
Miller, P.; Pannacciulli, N.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(SUPPLEMENT1), 42

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See detailExploring the effect of a second closely-timed infiltration of platelet-rich plasma to treat proximal patellar tendinopathies
Kaux, Jean-François ULg; CROISIER, Jean-Louis ULg; FORTHOMME, Bénédicte ULg et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 54(Suppl. 1 No. 2), 199

Intorduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to ... [more ▼]

Intorduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. Purpose: The aim of this study was to evaluate whether 2 infiltrations of PRP proves more effective than a single treatment. Methods: Twenty patients suffering from chronic jumper’s knee were enrolled into the study and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. Discussion and Conclusion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups at short to mid term. A second closely-timed infiltration of PRP to treat jumper’s knees is not necessary to improve the efficacy of this treatment in the short term. A second infiltration should perhaps be envisaged later, but this remains to be demonstrated. [less ▲]

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See detailEnglish translation and cross-cultural adaptation of the SarQuoL® questionnaire.
Beaudart, Charlotte ULg; Edwards, M.; Dennison, E.M. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 221-222

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See detailPhysical and muscle performances among elderly nursing home residents.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Croisier, Jean-Louis ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 217

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See detailTen years of Denosumab (DMAB) treatment in postmenopausal women with osteoporosis. Results from the FREEDOM Extension trial.
Bone, H.G.; Brandi, M.L.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 135-136

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See detailPrevalence of concomitant bone and muscle wasting in patients from the SarcoPhAge study.
Locquet, Médéa ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in Osteoporosis International (2016, April), 27(supplement 1), 129

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See detailBrain-derived neurotrophic factor (BDNF) in normal healthy and hemodialyzed populations.
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; KOVACS, Stéphanie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 512

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See detailPrevalence of frailty among nursing home, according to different operational definitions.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; GILLAIN, Sophie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 216-217

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See detailLINKING CATTLE GRAZING BEHAVIOR TO METHANE AND CARBON DIOXIDE DYNAMICS
Blaise, Yannick ULg; Lebeau, Frédéric ULg; Andriamandroso, Andriamasinoro ULg et al

in Communications in Agricultural and Applied Biological Sciences (2016, February), 81(1), 107-112

Various methods are presently used to measure methane (CH4) emissions of ruminants on pasture. Those measurements are essential to evaluate nutritional strategies to mitigate enteric CH4 emissions as well ... [more ▼]

Various methods are presently used to measure methane (CH4) emissions of ruminants on pasture. Those measurements are essential to evaluate nutritional strategies to mitigate enteric CH4 emissions as well as addressing the selection of low producing individuals. On pasture and in the barn, variations in CH4 emissions are observed depending on the time of the day. However, no studies have been made to link these diurnal fluctuations to behavioural phases, especially on pasture. The aim of this study was to understand the individual dynamics of CH4 production and their links to the grazing behaviour. For this purpose, a new tool was specifically developed. Five red-pied dry cows were equipped with infrared CH4 and carbon dioxide (CO2) sensors measuring concentrations in the exhaled air at 4 Hz. The animals were equipped with a heart rate belt (HR) and motion sensors to detect their feeding behaviours (grazing vs. rumination) for periods of 8 h/d. Wind speed (WS) was also monitor to verify interference with sampled gas concentrations. Results showed that using the CH4:CO2 ratio reduced the interference with WS that was observed on raw CH4 and CO2 concentration signals. CH4:CO2 ratio average over 5 min periods indicated that CH4 emissions were lower during grazing than rumination (P<0.01). The eructation frequency during grazing (0.48 eructation/min, P<0.01) was also lower than during rumination (0.65 eructation/min). HR was higher during grazing that rumination. Because HR is usually linked to metabolic CO2 production intensity, hence influencing the denominator of the CH4:CO2 ratio, further investigation should focus on the quantification of changes in fermentative and metabolic CO2 emissions along the day to estimate total CH4 production more accurately and the relationship between CH4 emissions patterns and post-feeding times. [less ▲]

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See detailOverview of Superhydrophilic, Photocatalytic and Anticorrosive Properties of TiO2 Thin Films Doped with Multi-walled Carbon Nanotubes and Deposited on 316L Stainless Steel
Léonard, Géraldine ULg; Remy, Simon; Heinrichs, Benoît ULg

in Materials Today: Proceedings (2016, February), 3(2), 434-438

TiO2 films with MWCNTs are produced for anticorrosive applications to increase the lifetime of steel materials. TiO2 has two additional properties, photoactivity and superhydrophilicity. Two TiO2 samples ... [more ▼]

TiO2 films with MWCNTs are produced for anticorrosive applications to increase the lifetime of steel materials. TiO2 has two additional properties, photoactivity and superhydrophilicity. Two TiO2 samples, synthesized in aqueous or alcoholic media, have been doped with MWCNTs. The material which best combines anticorrosive, superhydrophilic and photocatalytic properties, is the one produced in aqueous medium (Aq-TiO2-CNT). Doping with MWCNTs increases the photodegradation of p-nitrophenol from 18% to 50%. MWCNTs allow to reduce the corrosion current and the corrosion potential. The good superhydrophilicity of TiO2 is kept on stainless steel with a contact angle after illumination around 5°. [less ▲]

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See detailTrophic diversity of seagrass detritus copepods: A consequence of species-specific specialization or a random diet?
Mascart, Thibaud; De Troch, Marleen; Remy, François ULg et al

in PeerJ PrePrints (2016, January 13), 4

One of the major ecological research questions is understanding how biodiversity influences ecosystem functioning. Unravelling interspecific feeding preferences of organisms with overlapping trophic ... [more ▼]

One of the major ecological research questions is understanding how biodiversity influences ecosystem functioning. Unravelling interspecific feeding preferences of organisms with overlapping trophic niches will give part of the answer. Subsequently, the present study displays the trophic diversity of a benthic copepod community in a North-Western Corsican Posidonia oceanica seagrass ecosystem. These seagrass meadows are often interrupted by bare sand patches serving as deposition area for loose detritus. The accumulated macrophytodetritus, mainly derived from senescent macrophytes, harbour a diverse community of Harpacticoida (Crustacea, Copepoda). The most abundant copepods (i.e. three harpacticoids and one calanoid, belonging to different eco-morphological types) and their potential food sources (i.e. macrophytodetritus, epiphytic biofilm and suspended organic matter) were analysed for stable isotope ratios (δ13C, δ15N) and total lipids content. The results revealed a harpacticoid copepod feeding preference towards the epiphytic biofilm, while calanoid copepods preferred suspended organic matter. Additionally, a species-specific composition variation revealed finer partitioning of food resources (e.g. different micro-organisms present in the biofilm like bacteria, diatoms, fungi) over time.In conclusion, results showed species-specific food preferences, resulting in trophic niche and resource partitioning. Every eco-morphological type seems to cope in different ways with temporal fluctuations of food sources to comply with their nutritional needs. This illustrates the high resilience of the copepod community present in macrophytodetritus accumulations. Moreover, our results underlined the importance of multiple biomarker species-specific analysis in trophic ecology studies, especially in complex and dynamic environments offering numerous food items to consumers. [less ▲]

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See detailApports de l'électrophysiologie à la médecine d'expertise
WANG, François-Charles ULg

in Consilio manuque (2016), 1

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See detailRandomized, Double-Blinded, Controlled Clinical Trial Evaluating the Efficacy of a Diet Supplemented with Curcuminoids Extract, Hydrolysed Collagen and Green Tea Extract in Dogs with Osteoarthritis
Barthélémy, Nicolas; Comblain, Fanny ULg; Lesponne, Isabelle et al

in Veterinary and Comparative Orthopaedics and Traumatology (2016)

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See detailEpisodic memory and aging: The effect of perceptual processing fluency on recognition memory processes
Bastin, Christine ULg; Willems, Sylvie ULg

in Journal of Cognitive Neuroscience (2016), S2016

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See detailPsychometric properties of the Questionnaire of Executive Self-Awareness (QESA) for Children
Geurten, Marie ULg; Catale, Corinne ULg; Geurten, Claire ULg et al

in Journal of the International Neuropsychological Society (2016)

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of ... [more ▼]

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of appropriate instruments, few studies have examined the development of this ability among children. Method: This study tested the measurement properties of the self-rating and other-rating forms of the Questionnaire of Executive Self-Awareness (QESA), designed to tap children’s knowledge of their executive functioning. Participants were 317 children aged 7 to 14 years old. Results: Confirmatory factor analyses carried out on the QESA confirmed the eight-factor structure of both versions. There were significant correlations between the QESA and the parent versions of the BRIEF, DEX-C, and CHEXI. Both forms of the QESA were able to distinguish between children who had sustained a traumatic brain injury (TBI) and control participants. A self-other discrepancy score was computed to assess children’s executive self-awareness. A statistical difference was observed between the TBI and control groups on this score, suggesting that TBI may trigger self-awareness impairments in children. Conclusion: The good psychometric properties of the two forms of the QESA were established. Furthermore, results of the analyses carried on the different discrepancy scores seem to indicate that the QESA could help clinicians to detect patients with self-awareness deficits. [less ▲]

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See detailThe impact of factors related to retirement on cognitive functioning
Grotz, Catherine ULg; Adam, Stéphane ULg; Matharan, Fanny et al

in International Psychogeriatrics (2016), 27(supplement S1), 45-69

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See detailA Brief History of MPLS Usage in IPv6
Vanaubel, Yves ULg; Mérindol, Pascal; Pansiot, Jean-Jacques et al

in Lecture Notes in Computer Science (2016)

Recent researches have stated the fast deployment of IPv6. It has been demonstrated that IPv6 grows much faster, being so more and more adopted by both Internet service providers but also by servers and ... [more ▼]

Recent researches have stated the fast deployment of IPv6. It has been demonstrated that IPv6 grows much faster, being so more and more adopted by both Internet service providers but also by servers and end-hosts. In parallel, researches have been conducted to discover and assess the usage of MPLS tunnels. Indeed, recent developments in the ICMP protocol make certain categories of MPLS tunnels transparent to traceroute probing. However, these studies focus only on IPv4, where MPLS is strongly deployed. In this paper, we provide a first look at how MPLS is used under IPv6 networks using traceroute data collected by CAIDA. At first glance, we observe that the MPLS deployment and usage seem to greatly differ between IPv4 and IPv6, in particular in the way MPLS label stacks are used. While label stacks with at least two labels are marginal in IPv4 (and mostly correspond to a VPN usage), they are prevalent in IPv6. After a deeper analysis of the label stack typical content in IPv6, we show that such tunnels result from the use of 6PE. This is not really surprising since this mechanism was specifically designed to forward IPv6 traffic using MPLS tunnels through networks that are not fully IPv6 compliant. However, we show that it does not result from non dual-stack routers but rather from the absence of native IPv6 MPLS signaling protocols. Finally, we investigate a large Tier-1 network, Cogent, that stands out with an original set-up. [less ▲]

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See detailHistoire et expérience fondatrice dans Sein und Zeit
Zincq, Aurélien ULg

in Bulletin d'Analyse Phénoménologique (2016)

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See detailImplementation of the green payment within the scheme of the new Common Agricultural Policy (2015-2020): first results for 2015 in Wallonia (South of Belgium)
Burny, Philippe ULg; Terrones Gavira, François ULg

in Quality-Access to Success (2016), (Supplement), 10-14

At the end of 2013, a new Common Agricultural Policy was defined at the European level, including the implementation of the so-called “green payment”, which obliges farmers to respect three new conditions ... [more ▼]

At the end of 2013, a new Common Agricultural Policy was defined at the European level, including the implementation of the so-called “green payment”, which obliges farmers to respect three new conditions in order to get financial support through direct payments. The year 2015 being the first implementation year, the consequences on Walloon agriculture are examined. It appears that 50% of Walloon farmers are not obliged to practice crop diversification, while 16% are obliged to have at least two crops on their arable land and 33% are obliged to have at least three crops on their arable land. Less than 1% does not respect the new diversification rules. Concerning the obligation to have at least 5% of ecological focus area on the arable land, it appears that 54% of Walloon farmers are in conditions not to be obliged to respect the measure. When they implement the measure, the percentage of ecological focus areas in arable land reaches 6.9% as a mean and 2.4% do not reach the requested 5%. Finally, it can be said that the green payment does not represent a big constraint for Walloon farmers, though eventual economic consequences are still to be precised, while environmental benefits are strengthened. [less ▲]

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See detailDo the elderly feel older after exposure to negative aging stereotypes?
Marquet, Manon ULg; Missotten, Pierre ULg; Adam, Stéphane ULg

in International Psychogeriatrics (2016), 27(Supplement 1), 70-172

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See detailInfluence of crossed fields in structures combining large grain, bulk (RE)BCO superconductors and soft ferromagnetic discs
Philippe, Matthieu ULg; Fagnard, Jean-François ULg; Wera, Laurent ULg et al

in Journal of Physics: Conference Series (2016), 695

Bulk (RE)BCO superconductors are able to trap record magnetic fields and can be used as powerful permanent magnets in various engineering applications such as rotating machines and magnetic bearings. When ... [more ▼]

Bulk (RE)BCO superconductors are able to trap record magnetic fields and can be used as powerful permanent magnets in various engineering applications such as rotating machines and magnetic bearings. When such superconducting (SC) “trapped field magnets” are combined to a ferromagnetic (FM) disc, the total magnetic moment is increased with respect to that of the superconductor alone. In the present work, we study experimentally the magnetic behaviour of such hybrid FM/SC structures when they are subjected to cycles of applied field that are orthogonal to their permanent magnetization, i.e. a “crossed-field” configuration. Experimental results show that the usual “crossed-field demagnetization” caused by the cycles of transverse field is strongly reduced in the presence of the ferromagnet. [less ▲]

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See detailAgeism among nurses in oncology
Schroyen, Sarah ULg; Missotten, Pierre ULg; Jerusalem, Guy ULg et al

in International Psychogeriatrics (2016)

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See detailPhage therapy against antimicrobial resistance, design of the first clinical study Phagoburn.
Jault, Patrick; Gabard, Jérôme; Leclerc, Thomas et al

in Critical Care (2016), 20(Suppl 2), 109

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See detailDo Burundians have a more positive perception of older people than immigrants or Belgians?
Marquet, Manon ULg; Missotten, Pierre ULg; Nindaba, Desiderate et al

in International Psychogeriatrics (2016), 27(Supplement 1), 70-172

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See detailCroyances de la population générale au sujet des manipulations vertébrales
Demoulin, Christophe ULg; Baeri, D.; TOUSSAINT, Geoffrey ULg et al

in Revue du Rhumatisme (2015, December), 82S

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See detailQualités métrologiques de la version courte du Neurophysiology of Pain Questionnaire
Demoulin, Christophe ULg; Brasseur, P.; Roussel, N. et al

in Revue du Rhumatisme (2015, December), 82S

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See detailEvaluation of simplified flexibility evaluation tools using a unit commitment model
Quoilin, Sylvain ULg; Nijs, Wouter; Hidalgo, Ignacio et al

in IEEE Digital Library (2015, December)

Different tools and methods have been proposed in the literature to assess the required flexibility resources and needs in a particular grid or geographical area. However, few of them are readily usable ... [more ▼]

Different tools and methods have been proposed in the literature to assess the required flexibility resources and needs in a particular grid or geographical area. However, few of them are readily usable in long term energy planning models because they require small time steps and detailed data. In this paper, two candidate methods to address the flexibility issues in such models are evaluated. A unit commitment model developed at the JRC, DispaSET 2.0, is used as a test case for the different simplified flexibility assessment tools. The modelled geographical area is Belgium, using historical data for the demand and VRE curves and their day-ahead forecast. Different VRE penetration scenarios are simulated to evaluate the flexibility of the power system. The simplified assessment tools are then run with the same inputs. Results indicate significant discrepancies between the detailed Unit Commitment model and the simplified tools. The underlying reasons are described and suggestions are formulated to improve their accuracy. [less ▲]

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See detailWho are my Visitors and Where do They Come From? An Analysis Based on Foursquare Check-ins and Place-based Semantics.
Hallot, Pierre ULg; Stewart, Kathleen; Billen, Roland ULg

in Eurographics Workshop on Urban Data Modelling and Visualisation 2015 (2015, November 23)

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This ... [more ▼]

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This research investigates to what extent the anonymized data collected from social networks can be used as a basis for making activity recommendations associated with local residents versus tourists when visiting a public place, such as a museum or gallery. Using rules based on the spatial, temporal and semantics of visited places, we are able to infer if a user is likely to be local or a tourist, based on anonymous sample Foursquare data and place-based semantics retrieved using Google Places API. Using semantics of visited places, it becomes possible to infer additional information about a user based on their movements over space and time. Depending on the kind and frequency of visited places, inferences about the aim of a visit to a location are possible. This analysis could provide information to users in the form of recommendations based on their movements while travelling around an area. This study has been performed using Foursquare check-ins for visitors to the Art Institute of Chicago between March 2010 and January 2011. [less ▲]

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See detailPluto's atmosphere from stellar occultations in 2012 and 2013
Dias-Oliveira, Alex; Sicardy, Bruno; Lellouch, Emmanuel et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

We present results from two Pluto stellar occultations observed on 18 July 2012 and 04 May 2013, and monitored respectively from five and six sites in South America. Both campaigns involved large ... [more ▼]

We present results from two Pluto stellar occultations observed on 18 July 2012 and 04 May 2013, and monitored respectively from five and six sites in South America. Both campaigns involved large telescopes (including the 8.2-m VLT at ESO/Paranal). The high SNR ratios and multi-chord coverage provide amoung the best Pluto atmospheric profiles ever obtained from the ground.We show that a spherically symmetric, clear (no-haze) and pure N2 atmosphere with a unique temperature profile satisfactorily fits the twelve lightcurves provided by the two events. We find, however, a small but significant increase of pressure of 6% (6-sigma level) between the two dates, with values of 2.16 ± 0.2 and 2.30 ± 0.01 μbar at the reference radius 1275 km, respectively.We provide atmospheric constrains between 1190 km and 1450 km from Pluto's center, and we determine the temperature profile with accuracy of a few km in vertical scale. Our model shows a stratosphere with strong positive gradient between 1190 km (at 36 K, 11 μbar) and r =1215 km (6.0 μbar), where a temperature maximum of 110 K is reached. Above it is a mesosphere with negative thermal gradient of -0.2 K/km up to 1,390 km (0.25 μbar), at which point, the mesosphere connects itself to a more isothermal upper branch at 81 K. This profile provides (assuming no troposphere) a Pluto surface radius of 1190 ± 5 km, consistent with preliminary values obtained by New Horizons. Currently measured CO abundances are too low to explain the negative mesospheric thermal gradient. We explore the possibility of an HCN (recently detected by ALMA) cooling. This model, however, requires largely supersaturated HCN. Zonal winds and vertical compositional variations of the atmosphere are also unable to explain the observed mesospheric trend.These events are the last useful ground-based occultations recorded before the 29 June 2015 occultation observed from Australia and New Zealand, and before the NASA's New Horizons flyby of July 2015. This work can serve as a benchmark in the New Horizons context, enabling comparisons between ground-based and space results concerning Pluto's atmospheric structure and temporal evolution. [less ▲]

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See detailOutgassing and chemical evolution of C/2012 S1 (ISON)
Dello Russo, Neil; Vervack, Ronald J.; Kawakita, Hideyo et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ~ 25,000) infrared ... [more ▼]

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ~ 25,000) infrared spectroscopy as part of a worldwide observing campaign. Spectra were obtained on UT 2013 October 26 and 28 with NIRSPEC at the W. M. Keck Observatory, and UT 2013 November 19 and 20 with CSHELL at the NASA IRTF. H[SUB]2[/SUB]O was detected on all dates, with production rates increasing by about a factor of 40 between October 26 (R[SUB]h[/SUB] = 1.12 AU) and November 20 (R[SUB]h[/SUB] = 0.43 AU). Short-term variability of H[SUB]2[/SUB]O was also seen as the production rate increased by nearly a factor of two during observations obtained over a period of about six hours on November 19. C[SUB]2[/SUB]H[SUB]6[/SUB], CH[SUB]3[/SUB]OH and CH[SUB]4[/SUB] abundances were slightly depleted relative to H[SUB]2[/SUB]O in ISON compared to mean values for comets measured at infrared wavelengths. On the November dates, C[SUB]2[/SUB]H[SUB]2[/SUB], HCN and OCS abundances relative to H[SUB]2[/SUB]O appear to be close to the range of mean values, whereas H[SUB]2[/SUB]CO and NH[SUB]3[/SUB] were significantly enhanced. We will compare derived chemical abundances in ISON to other comets measured with infrared spectroscopy. [less ▲]

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See detailNitrogen Isotopic Ratios in Cometary NH2: Implication for 15N-fractionation in Ammonia
Shinnaka, Yoshiharu; Kawakita, Hideyo; Jehin, Emmanuel ULg et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Isotopic ratios in cometary molecules are diagnostic for the physico-chemical conditions where molecules formed and are processed, from the interstellar medium to the solar nebula. Usually temperatures at ... [more ▼]

Isotopic ratios in cometary molecules are diagnostic for the physico-chemical conditions where molecules formed and are processed, from the interstellar medium to the solar nebula. Usually temperatures at the molecular formation control the fractionation of the heavier element in molecular species, e.g., D-fractionation in water.In cometary volatiles, the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in CN have been well observed (Manfroid et al. 2009, A&A, 503, 613, and reference therein) and is consistent with the ratio in HCN (a most probable parent of CN) measured in few comets (Bockelée-Morvan et al. 2008, ApJ, 679, L49). Those ratios are enriched compared to the proto-solar value by a factor of ~3. In contrast to those Nitriles, there are only few reports on [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in Ammonia (as Amine) (Rousselot et al. 2014, ApJ, 780, L17; Shinnaka et al. 2014, ApJ, 782, L16). Ammonia (NH[SUB]3[/SUB]) is usually the most abundant and HCN is the second most abundant N-bearing volatiles in cometary ice. Especially, recent observations of [SUP]15[/SUP]NH[SUB]2[/SUB] revealed the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] are comparable to those of CN. However, from the viewpoint of theoretical work, the enrichment of [SUP]15[/SUP]N in cometary NH[SUB]3[/SUB] cannot be reproduced by current chemical network models. Information about the diversity of the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] of individual comets is needed to understand the formation mechanisms/environments of NH[SUB]3[/SUB] in the early solar system.To clarify the diversity of the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in cometary NH[SUB]3[/SUB], we determine the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] for more than ten comets individually which include not only Oort cloud comets but also short period comets by using the high-resolution optical spectra of NH[SUB]2[/SUB]. These spectra were obtained with both the UVES mounted on the VLT in Chile and the HDS on the Subaru Telescope in Hawaii.The derived [SUP]14[/SUP]N/[SUP]15[/SUP]N ratios in NH[SUB]3[/SUB] for more than ten comets show high [SUP]15[/SUP]N-enrichment compared with the elemental abundances of nitrogen in the Sun by about factor of ~3 and has no large diversity depending on these dynamical properties. We discuss about the origin of the formation conditions of cometary NH[SUB]3[/SUB] and its physico-chemical evolution in the solar nebula based on our and other results.This work was supported by JSPS, 15J10864 (Y. Shinnaka). [less ▲]

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See detailChariklo's size, shape and orientation from stellar occultations
Bérard, Diane; Sicardy, Bruno; Assafin, Marcelo et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

Chariklo is the largest Centaur object known to date, and it is surrounded by dense and narrow rings (Braga-Ribas et al. Nature 508, 72, 2014). The size, shape and orientation of the central body are ... [more ▼]

Chariklo is the largest Centaur object known to date, and it is surrounded by dense and narrow rings (Braga-Ribas et al. Nature 508, 72, 2014). The size, shape and orientation of the central body are important parameters to better understand the dynamics of the rings.In that context, we have analyzed three stellar occultations by Chariklo and its main ring observed on June 3, 2013, April 29, 2014 and June 28, 2014. Elliptical limb fitting to Chariklo’s main body occultation chords has been performed, where we denote a (resp. b) the semi-major (resp. semi-minor) axis of the limb. Preliminary results indicate that Chariklo’s limb is elliptical with axes ratio b/a~0.89. We obtain a~133 km and b~119 km, providing an equivalent radius of R[SUB]equiv[/SUB]=√(ab)~126 km. The rms dispersion of the fit, about 4 km, is compatible with local topographic features on a small icy body. For comparison, an equivalent radius of R[SUB]equiv[/SUB]= 119±5 km, based on thermal data, is given by Fornasier et al, AA 518, L11, 2014, while Duffard et al. AA 568, A79, 2014 estimate a= 122 km and b= 117 km.Our results are obtained under the simplifying assumption that the main ring is circular and that its center coincides with that of Chariklo. Caveats and error bars will be discussed, and dynamical implications will be presented. In particular, rough estimations of the ring apsidal precession rates will be given, as well as constraints on Chariklo's density. [less ▲]

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See detailReport on the ground-based observation campaign of 67P/Churyumov-Gerasimenko
Jehin, Emmanuel ULg

in Bulletin of the American Astronomical Society (2015, November 01), 47

Rosetta gets closer to the nucleus than any previous mission, and returns wonderfully detailed measurements from the heart of the comet, but at the cost of not seeing the large scale coma and tails. The ... [more ▼]

Rosetta gets closer to the nucleus than any previous mission, and returns wonderfully detailed measurements from the heart of the comet, but at the cost of not seeing the large scale coma and tails. The ground-based campaign fills in the missing part of the picture, studying the comet at about 1000 km resolution, and following how the overall activity of the comet varies. These data provide context information for Rosetta, so changes in the inner coma seen by the spacecraft can be correlated with the phenomena observable in comets. This will not only help to complete our understanding of the activity of 67P, but also to allow us to compare it with other comets that are only observed from the ground.The ground-based campaign includes observations with nearly all major facilities world-wide. In 2014 the majority of data came from the ESO VLT, as the comet was still relatively faint and in Southern skies, but as it returns to visibility from Earth in 2015 it is considerably brighter, approaching its perihelion in August, and at Northern declinations. I will present results from the 2014 campaign, including visible wavelength photometry and spectroscopy, and the latest results from 2015 observations. [less ▲]

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See detailFive years of comet narrow band photometry and imaging with TRAPPIST
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Bulletin of the American Astronomical Society (2015, November 01), 47

TRAPPIST is a 60-cm robotic telescope in La Silla Observatory [1] mainly dedicated to the study of exoplanets and comets. The telescope is equipped with a set of narrow band cometary filters designed by ... [more ▼]

TRAPPIST is a 60-cm robotic telescope in La Silla Observatory [1] mainly dedicated to the study of exoplanets and comets. The telescope is equipped with a set of narrow band cometary filters designed by the NASA for the Hale-Bopp observing campaign [2]. Since its installation in 2010, we gathered a high quality and homogeneous data set of more than 30 bright comets observed with narrow band filters. Some comets were only observed for a few days but others have been observed weekly during several months on both sides of perihelion. From the images, we derived OH, NH, CN, C[SUB]2[/SUB], and C[SUB]3[/SUB] production rates using a Haser [3] model in addition to the Afρ parameter as a proxy for the dust production. We computed production rates ratios and the dust color for each comet to study their composition and followed the evolution of these ratios and colors with the heliocentric distance.The TRAPPIST data set, rich of more than 10000 images obtained and reduced in an homogeneous way, allows us to address several fundamental questions such as the pristine or evolutionary origin of composition differences among comets. The evolution of comet activity with the heliocentric distance, the differences between species, and from comet to comet, will be discussed. Finally, the first results about the one year campaign on comet C/2013 US10 (Catalina) and our recent work on the re-determination of Haser scalelengths will be presented.[1] Jehin et al., The Messenger, 145, 2-6, 2011[2] Farnham et al., Icarus, 147, 180-204, 2000[3] Haser, Bulletin de l’Académie Royal des Sciences de Belgique,63, 739, 1957 [less ▲]

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See detailComparable transplant outcomes between DBD and DCD kidney grafts up to 5 years post-transplant: single centre experience
Ledinh, H; DETRY, Olivier ULg; DE ROOVER, Arnaud ULg et al

in Transplant International (2015, November), 28(S4), 193-194188

Introduction: This study aimed to determine the most recent results of kidney transplantation (KT) from donation after brain death (DBD) and circulatory death (DCD). Primary endpoints were graft and ... [more ▼]

Introduction: This study aimed to determine the most recent results of kidney transplantation (KT) from donation after brain death (DBD) and circulatory death (DCD). Primary endpoints were graft and patient survival, and graft function. Acute rejection and post-operative complications were assessed as secondary endpoints. Patient and Methods: This retrospective mono-center review consisted of 226 DBD- and 104 DCD-KT between 2008 and 2014. Results: Graft survival was comparable between two groups (95.1 vs. 91.1% at 1 year, 92.8 vs. 91.1% at 3 years and 89.2 vs. 91.1% at 5 years). 46% and 40% of graft loss were attributed to patient death with a functioning graft and rejection. Patient survival was comparable between 2 groups (97.8 vs. 95.1% at 1 year, 94.1 vs. 91.2% at 3 years, and 89.6 vs. 82.3% at five years). Etiology of patient death included cardiac arrest (16.7%), infection (16.7%), cancer (13.3%), and unknown cause (46.7%). Delayed graft function occurred in 14.6% of DBD- and 30.8% of DCD-KT (p = 0.001). Primary non function was encountered in 2.6% DBD- and 4.8% DCD-KT (p = ns). Graft function was worse in DCD than DBD up to 3 months post-transplant (p = 0.034), however, no difference existed afterwards. Biopsy-proven acute rejection was found in 12.8% and 13.5% of DBD- and DCD-KT during an average 3 months post- transplant (p = ns). This rate was 7.1% vs. 8.9% on surveillance biopsy performed between 3 and 6 months post-transplant (p = ns). Post-operativecomplication rate was comparable between 2 groups, concerning patient death, reoperation, transfusion, perirenal hematoma, macroscopic hematuria, urinary obstruction, wound problem, and infection. Nevertheless, contamination of preservation solution occurred more commonly in DCD than DBD (0.4% vs. 3.8%, p = 0.036). Conclusions: Despite worse early graft function, DCD-KT was not inferior to that originating from DBD up to 5 years post-transplant, therefore deserves to be used. [less ▲]

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See detailTransfusion needs during liver transplantation at the chu of liege (belgium): characteristics and preoperative predictive factors
PAGE, Isaline ULg; HANS, Grégory ULg; DETRY, Olivier ULg et al

in Transplant International (2015, November), 28(S4), 461272

Introduction: Liver transplantation (LT) can result in significant bleeding requiring transfusion of allogenic blood products, which potentially leads to postoperative morbidity and mortality (1). This ... [more ▼]

Introduction: Liver transplantation (LT) can result in significant bleeding requiring transfusion of allogenic blood products, which potentially leads to postoperative morbidity and mortality (1). This study aimed to determine transfusion needs during LT in our institution and its preoperative predictive factors. Material and Methods: Two hundred LT performed at the CHU Liege between 2006 and 2012 were respectively reviewed (age = 55 ` 11 yo, BMI = 25.5 ` 4.4 kg/m2, F/M = 45/155, MELD score = 19 ` 10). Transfu- sion needs of the different blood products during POD 0, and POD 0–7 were recorded. Parameters associated with the transfusion of more than 2 units of RBC (p ≤ 0.1) were identified using the Kruskal Wallis and chi square tests (table 1). These parameters were then placed into a backward stepwise logistic regression model for the transfusion of more than two units of RBC at POD 0. A p value threshold ≥0.1 was used for leaving the model. Results: Transfusion needs were: RBC = 2[0–4], FFP = 4[2–7], PLT = 1[0– 1] during POD 0; and RBC = 3[0–6], FFP = 6[3–10], PLT = 1[0–2] during POD 0–7. Preoperative factors independently associated with the transfusion of more than two units of RBC were preop Hb (0.6 [0.46–0.79], p < 0.001) and MELD score (1.13 [1.06–1.20], p < 0.001). Discussion: These results suggest that preop Hb and MELD score are associated with blood requirements during LT. [less ▲]

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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Transplant International (2015, November), 28(S4), 1027

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone mar- row progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Methods: 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5–3 9 106/kg third party MSC on post-operative day 3 ` 2. These patients were prospectively compared to a group of 10 control liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. This study is in part supported by an ESOT Senior Clinical Research Grant and by the University of Liege. [less ▲]

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See detailImpact of timing administration of mesenchymal stromal cells on serum creatinine following renal ischemia/ reperfusion in rats
ERPICUM, Pauline ULg; Rowart, Pascal ULg; POMA, Laurence ULg et al

in Transplant International (2015, November), 28(S4), 1129

Experimental models of renal ischemia/reperfusion (I/R) have suggested protective effects of mesenchymal stromal cells (MSC) therapy. Still, param- eters of MSC injection, including volume, route and ... [more ▼]

Experimental models of renal ischemia/reperfusion (I/R) have suggested protective effects of mesenchymal stromal cells (MSC) therapy. Still, param- eters of MSC injection, including volume, route and timing of cell administration, remain largely debated. Particularly, MSC infusion in mouse has been shown to be beneficial “a priori” but deleterious “a posteriori” of renal I/R injury. In order to further investigate the influence of the timing of MSC administration, we used 10-week-old Lewis rats categorized in 4 groups. Groups 1 (MSC D-7, n = 10) and 2 (MSC D + 1, n = 7) received caudal i.v. injection of MSC (1.5 9 106 in 1 ml of saline) 7 days before or 1 day after renal I/R, respectively. Control groups 3 (saline D-7, n = 6) and 4 (saline D + 1, n = 6) received equal volume of saline at similar time points. Left renal ischemia (by clamping of the renal pedicle) lasted 45 min. Right nephrectomy was simultaneously performed. Blood sample was collected from inferior vena cava at 48 h post reperfusion. MSC phenotype was confirmed by FACS analysis. In groups 1 and 3, serum creatinine (SCr) reached 1.4 ` 0.7 versus 2.4 ` 0.8 mg/dl, respectively (p < 0.05). In groups 2 and 4, SCr was 4.9 ` 0.7 versus 3.3 ` 0.9 mg/dl, respectively (p < 0.001). Furthermore, SCr levels were statistically worse when MSC were administered after renal I/R in comparison to a priori infusion (p < 0.0001). In conclusion, MSC administration 7 days prior to renal I/R attenuates kidney injury in comparison to (i) saline infusion or (ii) MSC infusion 1 day after renal I/R. Conversely, on the basis of SCr levels, MSC therapy performed after renal I/R worsens kidney injury in rats. [less ▲]

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See detailThird-party mesenchymal stem cell infusion in kidney transplant recipient: 6-month safety interim analysis
WEEKERS, Laurent ULg; ERPICUM, Pauline ULg; DETRY, Olivier ULg et al

in Transplant International (2015, November), 28(S4), 223-224278

Background: Mesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents. We report the 6- month safety results for the 5 first patients treated with MSC ... [more ▼]

Background: Mesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents. We report the 6- month safety results for the 5 first patients treated with MSC after kidney transplantation (KTx). Here, we address 3 specific safety issues: immunization against MSC and engraftment syndrome defined as acute graft dysfunction not related to rejection and over-immunosuppression. Patients and method: MSC production was carried out locally. MSC were not matched with kidney recipients’ HLA. Included patients were non-immunized, first transplant recipients from deceased donors. MSC (1.5–3.0 9 106/kg) infusion was planned 3 to 5 days post KTx. Patients with cardiovascular instability post KTx were excluded. All patients were treated with Basiliximab induction, Tacrolimus, Mycophenolate Mofetil and Steroid. We prospectively screened for anti-HLA antibodies at month 1, 3 and 6. Informed consent was obtained from all participants. The local ethical committee approved the protocol. Results: Collectively there were 23/50 and 29/50 HLA mismatches (MM) with kidney and MSC donor respectively, out of which 5 were shared MM. One patient developed de novo DSA, 2 patients anti-HLA antibodies against shared kidney/MSC MM and 1 patient developed 2 specific antibodies against MSC (MSCSA) at month 6. All antibodies were anti HLA class I except for 1. We did not observe any “engraftment” syndrome. Three patients experienced non- severe opportunistic infections: 1 CMV reactivation and 2 polyoma-BK virus viremia.Conclusion: We did not observe any strong safety signal. We did however observe some degree of immunization in 3 patients: 2 developed antibodies against shared kidney/MSC donor HLA MM and 1 MSCSA. [less ▲]

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See detailPourcentage de femmes atteignant des T-scores de DMO non ostéoporotiques au rachis lombaire (RL) et à la hanche totale (HT) après 8 ans de traitement par denosumab (DMAb)
Ferrari, S.; Libanati, C.; Lin, J. et al

in Revue du Rhumatisme (2015, November), 82(S1), 35-36

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See detailPourquoi dort-on?
BARREA, Christophe ULg

in 72ème Congrès du Gbpf: De Morphée au cauchemar (2015, November)

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See detailTraitement par denosumab chez des hommes à masse osseuse basse: résultats à 24 mois de l'étude ADAMO
Chapurlat, R.; Langdahl, B.; Teglbjaerg, C. et al

in Revue du Rhumatisme (2015, November), 82(S1), 123-124

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See detailOrgan donation after euthanasia on specific patients' request in Belgium
Ysebaert, D; DETRY, Olivier ULg; Verfaillie, G et al

in Transplant International (2015, November), 28(S4), 114313

Euthanasia is since 2002 legalized in Belgium for adults under strict conditions. The patient must be in a medically futile condition, of constant and unbearable physical or mental suffering that cannot ... [more ▼]

Euthanasia is since 2002 legalized in Belgium for adults under strict conditions. The patient must be in a medically futile condition, of constant and unbearable physical or mental suffering that cannot be alleviated, resulting from a serious and incurable disorder caused by illness. This implies that also non-terminal not-cancer patients can request for euthanasia for instance in case of debilitating neurological disorder. From 2005 till 2015 more than 25 patients, suffering from diverse neuropsychiatric diseases, got their request for euthanasia granted, and subsequently asked spontaneously for the possibility of organ donation. The involved physicians, the transplant teams and the Institutional Ethics Commit- tees, had the well-discussed opinion that this strong request for organ donation after euthanasia could not be denied. A clear separation between the euthanasia request, the euthanasia procedure and the organ procurement procedure was judged necessary. After extensive preparation, finally, in Belgium, 17 patients got their wish for organ donation after euthanasia fulfilled, in several academic or non-academic hospitals and in different regions. Several requests and preparations were started for other patients but ultimately did not lead to organ donation due to patients’ personal choices or logistically reasons. The euthanasia procedure was carried out by three physicians involved in the euthanasia granting. After clinical diagnosis of cardiac death, the procurement team came in and performed the organ procurement similar as in a DCD type III procedure. Almost always, liver, two kidneys and sometimes lungs and pancreatic islets were successfully recovered and transplanted, after allocation by Eurotransplant. The possibility of organ donation after their euthanasia provides a very much improved self-image of these patients, and adds something really positive to the unfortunate end-of-life of these patients. [less ▲]

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See detailA consecutive series of 100 controlled DCD liver transplantation
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Ledinh, H et al

in Transplant International (2015, November), 28(S4), 109296

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and ... [more ▼]

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and retransplantation. The authors retrospectively reviewed a single centre experience with controlled DCD-LT in a 12-year period. Patients and Methods: 100 DCD-LT were consecutively performed between 2003 and 2014. All donation and procurement procedures were performed as controlled DCD in operative rooms. Data are presented as median (ranges). Median donor age was 57 years (16–83). Median DRI was 2.16 (1.4–3.4). Most grafts were flushed with HTK solution. Allocation was centre-based. Median recipient MELD score at LT was 15 (7–40). Mean follow-up was 35 months. No patient was lost to follow-up. Results: Median total DCD warm ischemia was 19 min (10–39). Median cold ischemia was 235 min (113–576). Median peak AST was 1132 U/l (282– 21 928). Median peak bilirubin was 28 mg/dL. Patient survivals were 90.7%, 75.5% and 70.7% at 1.3 and 5 years, respectively. Graft survivals were 88.7%, 72.1% and 67.1% at 1.3 and 5 years, respectively. Biliary complications included mainly anastomotic strictures and extrahepatic main bile duct ischemic obstruction, that were managed either by endoscopy or hepatico- jejunostomy. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Discussion: In this series, DCD LT appears to provide results similar to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. If symptomatic ischemic cholangiopa- thy is diagnosed, adequate management with endoscopy and surgical hepaticojejunostomy may avoid graft loss and retransplantation. [less ▲]

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See detailIncreased risk of interstitial fibrosis and tubular atrophy in controlled donation after circulatory death kidney transplantation
WEEKERS, Laurent ULg; Ledinh, H; BONVOISIN, Catherine ULg et al

in Transplant International (2015, November), 28(S4), 49118

Introduction: Comparable transplant outcomes between controlled donation after circulatory death (cDCD) and donation after brain death (DBD) kidney transplantation (KT) have been confirmed. However, few ... [more ▼]

Introduction: Comparable transplant outcomes between controlled donation after circulatory death (cDCD) and donation after brain death (DBD) kidney transplantation (KT) have been confirmed. However, few data describes the histology of cDCD-KT which is subjected to prolonged procurement warm ischemia. This study aimed to evaluate the rate of interstitial fibrosis (IF) and tubular atrophy (TA) on the surveillance biopsy performed in our unit between the 2 and 6 months post KT. Acute rejection was considered as secondary endpoint. Patients and Methods: 330 KT (226 DBD and 104 DCD) have been performed between 2008 and 2014. Surveillance or per-cause biopsy was performed in 272 recipients. Among them, the rate of adequate (≥8 glomeruli and ≥1 large-sized artery) was 76.8%. Results: IFTA was found in 11.5% and 25.7% of DBD and cDCD-KT, respectively (p = 0.004). Considering IF and TA separately, the corresponding rates were 20.4% vs 32% (p = 0.04) and 23% vs 36% (p = 0.03), respectively. If acute rejection before routine biopsy was excluded, either IF or TA rate was significantly higher in cDCD- than DBD-KT (12.6% vs 27.1%, p = 0.006; 17.6% vs 31.4%, p = 0.016; and 20.9% vs 35.7%, p = 0.015 in case of IF-TA, IF, and TA, respectively). A cDCD-KT compared to a DBD-KT was 3.11 (95%CI 1.51– 6.43, p = 0.002), 2.34 (95%CI 1.21–4.53, p = 0.011) and 2.29 (95%CI 1.23– 4.27, p = 0.009) times more likely to have IFTA, IF, and TA, respectively. Extended criteria donor (ECD) vs standard criteria donor (SCD) was also an independent risk factor for IFTA (OR = 3.11, 95%CI 1.51–6.43, p = 0.002), IF (OR = 4.86, 95%CI 1.96–12.05, p = 0.001), and TA (OR = 4.09, 95%CI 1.68– 9.93, p = 0.002). The rate of acute rejection diagnosed by SB was 7.1% and 8.9% in DBD and cDCD kidney grafts (p = ns), respectively.Conclusion: KT from cDCD increased the risk of IF-TA between 3 and 6 months post-transplant. Further studies are warranted to investigate the evolution of this phenomenon over time and its effect on graft function. [less ▲]

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See detailLes machinimas : entre jeux et vidéos. Vers une poétique du détournement vidéoludique
Barnabé, Fanny ULg

in Culture Numérique (2015, October 10)

Cet article a pour objectif d’ébaucher la construction d’une théorie du détournement de jeux vidéo par les joueurs en passant, non pas par une perspective sociologique ou anthropologique, mais par ... [more ▼]

Cet article a pour objectif d’ébaucher la construction d’une théorie du détournement de jeux vidéo par les joueurs en passant, non pas par une perspective sociologique ou anthropologique, mais par l’analyse formelle des œuvres dérivées. Pour ce faire, le présent travail prend pour objet une pratique spécifique de détournement, la réalisation de machinimas, et l’aborde à travers un corpus illustratif de vidéos ayant pour point commun d’être issues des jeux Halo. L’analyse détaillée de quatre exemples prototypiques permettra de démontrer, d’une part, l’intime continuité qui existe entre la production de détournements et la pratique même du jeu (continuité qui rend donc artificielle toute tentative de démarcation stricte) et, d’autre part, la nature duelle du détournement de jeux vidéo (due à l’existence de deux aspects à détourner : le game et le play). La mise en parallèle de ces réflexions aboutira, enfin, dans la formalisation d’un modèle cartographiant les multiples formes de détournements. [less ▲]

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See detailDefining a score based on gait analysis for the longitudinal follow-up of MS patients
Azrour, Samir ULg; Pierard, Sébastien ULg; Van Droogenbroeck, Marc ULg

in Multiple Sclerosis Journal (2015, October 09), 23(S11), 408-409

BACKGROUND. The project GAIMS [ECTRIMS 2013 P800] aims at developing a gait measuring system particularily suited for the clinical routine, and providing a reference database with the gait characteristics ... [more ▼]

BACKGROUND. The project GAIMS [ECTRIMS 2013 P800] aims at developing a gait measuring system particularily suited for the clinical routine, and providing a reference database with the gait characteristics of many MS patients (MSP) and healthy people (HP). As the gait impairments are related to the disease progression, defining an objective and quantitative score based on the gait characteristics would be useful for the longitudinal follow-up. Based on the dataset of GAIMS and machine learning techniques (MLT), a score, well correlated with the EDSS, can be defined [Azrour et al. ESANN 2014]. OBJECTIVE. Burggraaff et al. [ECTRIMS 2014 P033] showed that paired comparisons can help human raters to better judge the state of the patients. In the same spirit, we aim at predicting the difference of EDSS between two persons or between two visits of a same person, based on clinical gait measures. We show that the pairwise comparison strategy leads to a score (Gait-Score) well correlated with the EDSS and sensitive to small modifications of the gait. METHODS. The gait of 162 HP and 72 MSP (44 with EDSS>3) has been recorded and analyzed with GAIMS. The Gait-Score is defined using the MLT of [Geurts et al. 2006]. We can compute the Gait-Score of a person by comparing him to others with known EDSS, and compute the difference of Gait-Score of a same person at two different moments. We measure the merits of the Gait-Score by the correlation between the predicted Gait-Score and the EDSS, as well as the ability to detect subtle gait deteriorations among people with ataxia induced by a low dose of alcohol (data of [Piérard et al. ESANN 2014]). RESULTS. The Gait-Score is well correlated with the EDSS (Pearson’s correlation=0.8743). Moreover, it manages to detect a gait deterioration after a small alcohol intake for 19 persons out of 24 (79% correct) which is much better than what was obtained by visual inspection of neurologists (62% according to [Piérard et al. ESANN 2014]). CONCLUSIONS. Based on the accurate gait measures provided by GAIMS, we are able to derive a Gait-Score, automatically, that is well correlated with the EDSS. Moreover, this score is able to detect subtle deteriorations of the gait caused by a low dose of alcohol. These results reinforce our conviction that the use of an automatic method based on gait analysis is very promising for the longitudinal follow-up of MS patients and the assessment of the impact of new drugs and rehabilitation programs. [less ▲]

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See detailUnderstanding how people with MS get tired while walking
Pierard, Sébastien ULg; Phan-Ba, Rémy; Van Droogenbroeck, Marc ULg

in Multiple Sclerosis Journal (2015, October 09), 23(S11), 406

BACKGROUND. Walking impairment is frequent, appears early in the disease course of MS patients (MSP), and is perceived as the most disabling symptom. When walking, patients get tired more and differently ... [more ▼]

BACKGROUND. Walking impairment is frequent, appears early in the disease course of MS patients (MSP), and is perceived as the most disabling symptom. When walking, patients get tired more and differently than healthy people (HP) [Phan-Ba et al PLOS 2012]. This limits their walking perimeter. Understanding this phenomenon is thus important to suggest adequate therapies at the right time. OBJECTIVE. Our aim is to understand how MSP get tired while walking compared to HP. Two groups of MSP are considered: those with a low disability level (MSPL) and those with a high one (MSPH). We consider two criteria to measure the disability: the EDSS and the deceleration index (DI) [Phan-Ba et al PLOS 2012]. The limit between the groups is set at DI=0.8 and EDSS=3 (inclusive for MSPL). METHODS. Many gait characteristics (GC) have been measured with the system GAIMS along a 500m path walked as fast as possible. The dataset gathers 464 visits of HP and 70 of MSP. Some people have been assessed several times. There are 33 visits in the group MSPL with the EDSS criterion, and 25 with the DI criterion. Statistical tests (Welch) were performed on the differences and relative differences of the GC measured during the first and last 100m of the test to detect differences between HP and MSPL, and between MSPL and MSPH, as in [ECTRIMS 2012 P755]. RESULTS. Both criteria for defining the groups lead to similar conclusions. For many GC, the distributions of the variations are significantly different between MSPL and MSPH. The largest difference is for the relative difference of speed (p=0.000119 for EDSS and p=0.000021 for DI). In contrast, only the variation of the average lateral distance between the feet, which is related to the size of the base of support (and thus to the balance) shows a very significant difference between HP and MSPL (p=0.000116 for EDSS and p=0.000120 for DI). The balance does not seem to change much from MSPL to MSPH. Besides, we note that the variance decreases slightly from HP to MSPL and increases a lot from MSPL to MSPH. CONCLUSIONS. Statistically, from the motor fatigue point of view, it seems that the course of the MS disease is divided in two different stages. In the first one, MSP get more tired than HP because of a deterioration of the balance. Then, in the second one, their fatigue becomes related to a faster decrease of the walking speed. This suggests that physical therapy exercises focused on the balance could be given to MSP in the early stage of the disease. [less ▲]

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See detailSynthèse du débat politique. Journée de réflexion au Sénat de Belgique: «Démocratie représentative : vers la fin d’un modèle ? Diagnostic et remèdes»
Verjans, Pierre ULg

in Compte-rendu du Sénat de Belgique (2015, October 01)

Les réflexions des responsables politiques en réaction aux interventions des scientifiques peuvent être interprétées en fonction de grille d'analyse de science politique, notamment celle d'Amartya Sen et ... [more ▼]

Les réflexions des responsables politiques en réaction aux interventions des scientifiques peuvent être interprétées en fonction de grille d'analyse de science politique, notamment celle d'Amartya Sen et celle de Bernard Manin. [less ▲]

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See detailOnychomycosis: is it possible to increase the cure rate?
Hayette, Marie-Pierre ULg

in Mycoses (2015, October), 58(suppl 4), 35

Onychomycosis represent about 50% of nails disorders in the world with a very variable prevalence depending of the countries considered. Dermatophytes, non-dermatophyte molds and Candida sp. are the main ... [more ▼]

Onychomycosis represent about 50% of nails disorders in the world with a very variable prevalence depending of the countries considered. Dermatophytes, non-dermatophyte molds and Candida sp. are the main causing agents. A rapid and accurate diagnosis is essential in order to give an adequate treatment to the patient. Generally, a combination of microscopy and culture is used for laboratory diagnosis. However, microscopy does not always allow the distinction between yeasts or filamentous fungi, culture takes generally about a week before identification and the result is compromised if there is contamination by not relevant fungi. Therefore commercially available PCR-based methods have been developed in order to provide a rapid and accurate identification of dermatophytes and yeasts in nails samples. Combination of microscopy and PCR may provide a rapid and specific diagnosis in 2 working days. However this methodology is still not widely used by laboratories because of the high cost. Furthermore, this technology can detect DNA from dead fungi and therefore is not suitable for assessment of treatment efficacy. Onychomycosis therapy depends on different factors such as the causative agent, the number of nails and degree of nail involvement, the type of onychomycosis, potential drug interactions or drug intolerance and a failure to previous treatments. Oral and topical antifungals are mostly used separately or in combination. Oral therapy includes azoles (itraconazole, fluconazole) and/or allylamine (terbinafin), this latter being the most frequently prescribed antifungal for treatment of onychomycosis in North America and Europe. Topical amorolfine and ciclopirox formulations can be used alone in mild cases or in case of intolerance to oral antifungals. However, one of the biggest problems of therapy for onychomycosis is the high frequency of relapse which concerns about 20 to 40% of the patients treated by oral antifungals. Different strategies have been developed to overcome this problem amongst which are: optimization of the dosing regimens (continuous vs pulse therapy) or therapy duration, combination therapy (nail debridement + antifungals, oral + topical drugs, 2 oral drugs), improving drug delivery (use of physical or chemical enhancers, and modification of the pharmacological formulation for increasing drug uptake). Some strategies such as combination therapy (oral + topical) have demonstrated enhanced efficacy and should be recommended in case of poor efficacy of the initial treatment or in case of extended infection. Prophylactic topical therapy implemented after completion of oral treatment has been shown to delay relapse. Preventive measures such as treatment of concurrent tinea pedis and/or infected family members and regular cleaning of bathroom and shower floors can help to reduce the risk of reinfection particularly when a dermatophyte is the causative agent. In conclusion, treatment for onychomycosis is associated with frequent relapse. Consequently, follow-up is mandatory and combination therapy can be necessary in case of relapse or resistance to treatment. Patients should also be aware of the preventive hygiene measures to apply in order to decrease the risk of reinfection. New strategies improving treatment efficacy are promising but their efficacy have still to be demonstrated in comparative clinical trials before their implementation in therapy. [less ▲]

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See detailEpidemiological aspects and genotypic characterization of T.violaceum strains collected during a Belgian National survey on anthropophilic tinea
SACHELI, Rosalie ULg; Dekkers, Charlotte; GRAIDE, Hélène ULg et al

in Mycoses (2015, October), 58(Supplement 4), 189

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the ... [more ▼]

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the population, the Belgian National Reference Center (NRC Liège) launched a one-year national survey in 2013. Epidemiological aspects and genotypic characterization of the strains were included. Methods The study was conducted from March 2013 up to February 2014. All Belgian laboratories were asked to send M. audouinii and T. violaceum strains isolated from hair to the NRC with a form to fill in including epidemiological data. The fungal strains were identified by microscopy or ITS sequencing in case of doubtful identification. The genotypic analysis was performed by the DiversiLab® system (bioMérieux) for DNA fingerprinting and analysis. Epidemiological data were analyzed with the help of a biostatistician. Results Amongst the collected isolates, 23 strains were confirmed as T.violaceum (results concerning the 116 M. audouinii strains have already been reported). Analysis of the epidemiological characteristics of the infected population shows that the main age category concerns 0-4 year-old children (n=9, 39,1%) with a sex-ratio M/F of 1.875. Data concerning the geographic origin of the family were present in 82,6% of the cases and reveal that patients were mainly of Ethiopian origin (n=8, 57,9% of known cases). One patient was also from Burundi showing that T. violaceum strains probably circulate mainly in East Africa. The genotypic analysis led to the distinction of 2 variants of T. violaceum. The major group was composed of 17 strains which were mainly collected in the North of Belgium and included also the reference strain (18/23, 83,3%). The other group (6 strains) was close to the major group but the analysis of the spectral superposition showed some differences between these two groups, defining two distinct variants of T. violaceum in the Belgian population. This second variant was mainly recovered from South Belgium (5/6, 83,3%). No correlation could be made between the genotypic group and a particular ethnical origin as Ethiopian subjects were found in both groups. Conclusion The DiversiLab® system proved to be an efficient method to investigate the molecular epidemiology of dermatophytes infections as reported previously for M. audouinii. These results show that two distinct isolates co-exist in Belgium providing evidence of genetic heterogeneity and a possible spread of one genotypic variant in a restricted geographic area or the co-existence of two variants circulating in different African communities. However, no clear correlation could be established between the appartenance to a group and epidemiological factors, such as age or ethnical origin. [less ▲]

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See detailUsing S-Monovette° lower the rate of hemolysed specimen from a belgian academic emergency department
VRANKEN, Laura ULg; DELCOUR, Sandra ULg; CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2015, October)

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See detailSofosbuvir in combination with simeprevir +/- ribavirin in genotype 4 hepatitis C patients with advanced fibrosis or cirrhosis: a real-life experience from Belgium
Moreno, C; Lasser, L; DELWAIDE, Jean ULg et al

in Hepatology (Baltimore, Md.) (2015, October), 62(1), 746

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However ... [more ▼]

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However, efficacy and safety data of interferon-free regimens in HCV genotype 4 (G4) patients are scarce. In Belgium, Sofosbuvir (SOF) and Simeprevir (SMV) treatment is available since January 2015 for G4 patients with advanced fibrosis (F3-F4 METAVIR) for 12 weeks. Methods: analysis of HCV G4 patients receiving SOF and SMV treatment in Belgium. The aim of the study was to evaluate the safety and efficacy of the treatment. Results: 73 G4 patients were enrolled in this data collection including 32 (43.8%) patients with severe fibrosis F3 and 41(56.2%) cirrhotic patients. The study population comprised 58.9% male, 77.8% treatment experienced patients. Median age was 59 [51-66] years and 5 patients were HCV/HIV co-infected. 24 patients received the treatment associated with ribavirin, 11/32 (34.37%) of patients with advanced fibrosis and 13/41 (31.71%) of cirrhotic patients. In cirrhotic patients, median MELD and Child-Pugh score were 9 [7-12.5] and 5 [5-6], 46.2% had platelet below 100.000/mm and 28.6% had albumin below 35 g/L. W4 HCV RNA was undetectable in 31.25% (15/48). 9 of the 15 patients with undetectable W4 HCV RNA received RBV. At W12, 100% (23/23) had HCV RNA below the limit of quantification, with 6/23 still detectable. All SVR12 data will be available at the time of presentation. No patient experienced serious adverse event. Conclusions: these preliminary results in difficult-to-treat G4 HCV patients show that SOF/SIM +/- RBV treatment is safe and seems promising, in line with that was observed in G1 HCV patients. [less ▲]

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See detailA three year survey of dermatophytoses in Belgium
SACHELI, Rosalie ULg; DARFOUF, Rajae ULg; GRAIDE, Hélène ULg et al

in Mycoses (2015, October), 58(Supplement 4), 135

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide ... [more ▼]

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide. Epidemiological studies regarding dermatophyte infections have been conducted in several countries and differences in the incidence and in etiological agents have been reported for different geographical areas. That is why national surveillance of circulating strains causing dermatophytosis is crucial. The Belgian National Reference Center (NRC) for Mycoses conducted a survey on dermatophytes strains circulating from 2012 to 2014. The present study was performed to assess the profile of dermatophytosis and to identify the species involved. Methods The Belgian NRC for Mycosis collected 9138 strains between January 2012 and December 2014. The isolates were cultured from patients clinically suspected for fungal infections of skin, hair and nails. Isolates were sent by Belgian laboratories to the two labs of the Belgian NRC (UZ Leuven and CHU of Liège) in order to identify the fungus or to confirm the identification. All isolates cultured from patients of UZ Leuven and CHU of Liège were also included. Fungal identification was performed by microscopy after subculture and in case of doubtful identifications by ITS sequencing. Results .Among the 9138 samples (results of UZ Leuven and CHU of Liège combined), 3587 were identified as dermatophytes. Trichophyton. rubrum (T. rubrum) was the most prevalent species accounting for 56,17% (n=2015) of the infections from all sources, followed by T. mentagrophytes complex (21,83%, n=783). The other main etiological agents of dermatophytosis recorded in this study in descending order of prevalence were M. audouinii (n=303), M. canis (n=120), T. violaceum (n=112), T. tonsurans (n= 95), T. soudanense (n=66), M. praecox (n=59), E. floccosum (n=14) Our data reveal the predominance of anthropophilic species causing tinea capitis especially M. audouinii responsible for 36,49% (n=163/448) of hair/scalp infection. Trichophyton violaceum rarely observed in our country is frequently found as 12,8% (n=57) of the reported cases of tinea capitis are due to this species. The retrospective evaluation of data collected also shows that zoophilic strains as M. canis well represented in the past epidemiology of tinea capitis, is decreasing in frequency accounting for only 7,2% (n=32) of clinical cases. Finally, our data confirm the high prevalence of T. rubrum commonly observed in Europe as causal agent of onychomycosis (70,9%, n=1603) followed by T. mentagrophytes complex (20,9%, n=455). T. rubrum and T. mentagrophytes complex are also responsible for the majority of skin infections as they represent respectively 40% (n=386) and 24,75% (n=239) of skin dermatophytosis during the study period. Conclusions The present work has provided recent data on the prevalence of several dermatophytes species circulating in Belgium. Such data is critical for the establishment of therapeutic strategies and measures for prevention and control of dermatophytes infections. Our study confirms the predominance of T. rubrum followed by T. mentagrophytes in the Belgian population but also highlights the emergence of new anthropophilic species such as M. audouinii and T. violaceum as causative agents of tinea capitis in children in relation with African immigration. [less ▲]

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See detailMPLS Under the Microscope: Revealing Actual Transit Path Diversity
Vanaubel, Yves ULg; Mérindol, Pascal; Pansiot, Jean-Jacques et al

in ACM Internet Measurement Conference (2015, October)

Traffic Engineering (TE) is one of the keys for improving packet forwarding in the Internet. It allows IP network operators to finely tune their forwarding paths according to various customer needs. One ... [more ▼]

Traffic Engineering (TE) is one of the keys for improving packet forwarding in the Internet. It allows IP network operators to finely tune their forwarding paths according to various customer needs. One of the most popular tool available today for optimizing the use of networking resources is MPLS. On the one hand, operators may use MPLS and label distribution mechanisms such as RSVP-TE in conjunction with BGP to define multiple transit paths (for a given edge pair) verifying different constraints on their network. On the other hand, when operators simply enable LDP for distributing MPLS labels in order to improve the scalability of their network, another kind of path diversity may appear thanks to the ECMP feature of IGP routing. In this paper, using an MPLS labels analysis, we demonstrate that it is possible to better understand the transit path diversity deployed within a given ISP. More specifically, we introduce the Label Pattern Recognition (LPR) algorithm, a method for analyzing traceroute data including MPLS information. LPR reveals the actual usage of MPLS according to the inferred label distribution protocol and is able to make the distinction between ECMP and TE multi-path forwarding. Based on an extensive and longitudinal traceroute dataset obtained from CAIDA, we apply LPR and find that each ISP behavior is really specific in regard to its MPLS usage. In particular, we are able to observe independently for each ISP the MPLS path diversity and usage, and its evolution over time. Globally speaking, the main outcomes of our study are that (i) the usage of MPLS has been increasing over the the last five years with basic encapsulation being predominant, (ii) path diversity is mainly provided thanks to ECMP and LDP, and, (iii), TE using MPLS is as common as MPLS without path diversity. [less ▲]

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See detailValidation of the DermaGenius Nail plus multiplex assay, a new commercial PCR assay developed for the detection and identification of dermatophyte and Candida in nails
Hayette, Marie-Pierre ULg; GRAIDE, Hélène ULg; ADJETEY BAHUN, Akolé ULg et al

in Mycoses (2015, October), 58(suppl 4), 223

Objectives Superficial dermatophytosis is the most common fungal infection in humans. Diagnosis of dermatophytosis is currently based on microscopy or histology associated with culture on specific agar ... [more ▼]

Objectives Superficial dermatophytosis is the most common fungal infection in humans. Diagnosis of dermatophytosis is currently based on microscopy or histology associated with culture on specific agar media. However, direct microscopy lacks specificity and culturing has a long turn-around-time of 2-4 weeks. These limitations can be prevented by the use of molecular diagnostics. The DermaGenius (DG) multiplex kit (PathoNostics, The Netherlands) is a new commercial realtime-PCR kit, which can differentiate various dermatophytes species including the nail pathogens T. rubrum, T. mentagrophytes, T. interdigitale and 2 Candida species (C. albicans and C. parapsilosis). This study aimed at the validation of the kit on nails clippings. Results were compared with histology and culture data. Methods A set of 76 nail clippings was collected from 76 patients attending the dermatology consultation at the University Hospital of Liege on suspicion of onychomycosis. All nails were divided in three pieces for histology, culture and the PCR multiplex assay. Histologic preparations were stained with PAS staining. Cultures were performed on 2 different Sabouraud agar medium slants (bioMérieux). The DNA extraction protocol used a proteinase K pre-treatment followed by an automated DNA-extraction (EasyMag, bioMérieux). An Internal Control (IC) was included to monitor for PCR inhibition or manual errors. The realtime-PCR amplification was performed with the DG kit on a Rotor-Gene Q instrument (Qiagen) by using quantitative amplification and melting curve analysis. Results In total, 35 of 76 cases (46%) were classified as confirmed onychomycosis based on positive microscopy (M+) with or without positive culture (C+) or just by positive culture of a confirmed pathogen. Based on negative microscopy (M-) and negative culture of a confirmed pathogen, 41 cases (54%) were reported as non-fungal onychodystrophy. Agreement between DermaGenius (DG) and culture was found in 52% of the cases while 86% agreement was reported when comparing positive DG with confirmed onychomycosis. Three positive cultures (microscopy negative) were not detected by DG (2 T. rubrum, 1 C. albicans). However, DG could detect 7 additional infections (9%). Eleven discrepancies DG+/C+ were determined which could be positively confirmed in favour of DG result by ITS sequence analysis. Most discrepancies could be explained by fungal/yeast species overgrowing the agar slant, including species of Candida, Fusarium, Trichosporon, which were not considered as the source of infection. Conclusion The DermaGenius Nail plus multiplex was able to detect the most prevalent pathogenic dermatophytes species in clinical nail specimens and proved to be more sensitive and specific than culture and direct microscopy. The DNA extraction procedure has been shown to work efficiently in diagnostics which enables the physician in charge of the patient to start a dedicated treatment rapidly. [less ▲]

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See detailL’image dans le concours d’architecture : Méthodologie de lecture de la représentation graphique du projet
Boutemadja, Abdelkader ULg; Reiter, Sigrid ULg

in AISV 2015 (2015, September 08)

Nous assistons depuis quelques décennies au développement de nouveaux modes de production des représentations graphiques en architecture. Ces développements ont des raisons multiples mais la principale ... [more ▼]

Nous assistons depuis quelques décennies au développement de nouveaux modes de production des représentations graphiques en architecture. Ces développements ont des raisons multiples mais la principale semble être l’essor qu’a connu l’usage de l’outil informatique dans nos sociétés de manière générale mais aussi dans les domaines de liés à l’édification dont l’architecture et l’urbanisme. Le recours aux images 3D assistées par ordinateur est aussi apparu très tôt surtout dans le cadre des concours d’architecture. Pour produire les images les plus séduisantes, les logiciels d’architecture et d’urbanisme (DAO, CAO, BIM, SIG, …) sont devenus de plus en plus performants et intuitifs. Dans le cadre plus particulier des concours d’architecture, cette utilisation de l’outil informatique et des nouveaux modes de représentation graphique se trouve exacerbée. Chaque concours devient d’occasion, pour les architectes qui y participent, de recherche et d’innovation – non seulement architecturale – mais aussi dans la manière de représenter et de communiquer cette architecture. Qu’elles sont les nouvelles stratégies de communication portées par les représentations graphiques du projet que l’architecte cherche à mettre en place dans un concours d’architecture ? Existe-t-il une logique commune, liée aux nouveaux modes de production, à ces stratégies de communication du projet ? Ces nouvelles typologies de représentation graphique ont elles une influence sur les typologies architecturales produites, plus particulièrement dans les concours d’architecture ? Ce sont ici les questions principales que nous nous posons et auxquelles nous cherchons à répondre au travers de cet article. [less ▲]

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