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See detailMaternal transfer of trace metals to offspring in grey seals
Habran, Sarah ULg; Pomeroy, Paddy; Debier, Cathy et al

Conference (2010, May 25)

Marine mammals may display high heavy metal levels in their tissues, which raises the question of the importance of toxic metal transfer from mother to offspring. Some lactating female phocids fast during ... [more ▼]

Marine mammals may display high heavy metal levels in their tissues, which raises the question of the importance of toxic metal transfer from mother to offspring. Some lactating female phocids fast during the suckling period. This fasting period involves not only an important mobilization of energy reserves, but also mobilization of potentially associated contaminants. We studied maternal transfer of trace metals to offspring in the grey seal (Halichoerus grypus). Trace metal concentrations were measured in whole blood, milk and hair of mother-pup pairs in early and late lactation. Metal levels in blood decreased according to the following pattern: Fe > Zn > Se > Cu > Hg > Pb > Cr > V in mothers and pups. Cd and Ni were not detected and V, Cr and Pb levels were very low in maternal and pup blood. However, Ni and Pb levels were detected in the milk showing a transmammary transfer of these metals. Hg levels in blood and milk were higher than levels of previous metals and levels varied significantly throughout lactation. The increasing maternal levels over lactation were likely due to the remobilization of energy reserves during fasting and milk production in mothers causing a Hg release in blood. All metals were detected in hair and lanugo according to the following pattern: Fe > Zn > Hg > Cu > Se > Ni > V > Pb > Cd > Cr in mothers and Zn > Fe > Hg > Se > Cu > Pb > Ni > V > Cr > Cd in pups. Pb levels were relatively high in comparison with other phocid species. Only Hg showed a significant relationship between hair/lanugo and blood levels. This study highlights (i) a transplacental and transmammary transfer of metals in grey seals, and shows that (ii) physiological processes such as lactation and/or fasting can modify trace metal levels in the blood of mothers and pups. [less ▲]

Detailed reference viewed: 64 (11 ULg)
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See detailSynthesis and Characterization of Mechanically linked copolymers
Van Quaethem, A.; Lussis, Perrine ULg; Duwez, Anne-Sophie ULg et al

Conference (2010, May 25)

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See detailGlucose-responsive layer-by-layer microcapsules: a potential route to self-regulated insulin delivery
Alaimo, David ULg; Detrembleur, Christophe ULg; Auzély-Velty, Rachel et al

Conference (2010, May 25)

Detailed reference viewed: 32 (5 ULg)
See detailLa GRH, levier de changement?
Pichault, François ULg

Conference (2010, May 22)

Detailed reference viewed: 76 (9 ULg)
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See detailNouveaux agents anti-inflammatoires en série N-(4-pyridyl)alcanesulfonamide
Renard, Jean-François ULg; Lecomte, Frédéric ULg; de Leval, Xavier et al

Conference (2010, May 21)

Detailed reference viewed: 70 (19 ULg)
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See detailL’orgueil de Foucault. Ontologie, expérience et critique
Bolmain, Thomas ULg

Conference (2010, May 20)

Detailed reference viewed: 22 (7 ULg)
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See detailPolitiques, stratégies et pratiques en cours à la FAPSE de l’ULg et dans les Hautes Écoles de la Communauté française de Belgique
Denis, Brigitte ULg

Conference (2010, May 20)

The author presents different uses of ICT in courses and training curriculums at the Faculty of Psychology and Educational Sciences of the University of Liège. She also deals with some considerations on ... [more ▼]

The author presents different uses of ICT in courses and training curriculums at the Faculty of Psychology and Educational Sciences of the University of Liège. She also deals with some considerations on initial and continuous training in ICTE uses in High Schools of the French Community of Belgium. The presentation ends on different elements to be considered about policies, strategies and practices (e.g. Insertion of courses in the official initial training curriculums, teachers' certification in ICT and ICTE in Higher Education, ICT mastery...ergonomy and acceptability of tools, isomorphism principle, evaluation, creation and animation of networks and communities of practice to sustain contiunous traing). [less ▲]

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See detailHow King Leopold II used Emile de Laveleye’s intellectual network for the benefit of his African project…
Vandersmissen, Jan ULg

Conference (2010, May 20)

The “Belle Epoque” saw the revival of the colonial idea in new forms. A second European colonization wave washed over Africa. King Leopold II unfolded his activities in Congo from 1876 onwards. There, his ... [more ▼]

The “Belle Epoque” saw the revival of the colonial idea in new forms. A second European colonization wave washed over Africa. King Leopold II unfolded his activities in Congo from 1876 onwards. There, his efforts to develop a so-called “philanthropic” enterprise soon evolved in a process of state formation, overshadowed by intrigues and tensions that were a consequence of colonial competition between the western powers. Only a decade later, at the Berlin Conference of 1885, a definite arrangement was adopted. Everywhere in Europe, a disputed transition was made from liberal to more conservative ways of government. Of course this tension field also dominated intellectual life. There was an intense debate between partisans of colonialism and supporters of worldwide free trade. For the development of his colonial doctrine Leopold II had been inspired by intellectuals that supported economic expansionism. Most of them were active in the field of economic geography. But the King also searched for support in other academic circles and mobilized one of Europe’s brightest minds to join him in his quest for the most adequate economic, social and political model of a future state in the heart of Africa. In his books, articles and pamphlets, the liberal minded political economist Emile de Laveleye (1822-1892) – an opinion maker of European renown – showed himself an unshakable opponent of colonization and imperialism. However, in the period 1875-1885 – a decade so crucial for Congo – a surprising intellectual rapprochement between de Laveleye and Leopold II was established. For a certain time, this competent man of science advised the King, for example at the International Geographical Conference in Brussels, putting into royal service an intellectual network of European range. This paper investigates how, in the complex and constantly evolving public discussion about Congo, two apparently opposing minds attracted each other. Analyzing de Laveleye’s publications and correspondence we focus on his important pleas for a “neutral and international formula” that would place Leopold II in a conflicting situation with Portugal and France, countries that claimed Congo’s estuary for their own benefit. De Laveleye believed that Leopold was sincere about his civilizing mission and crusade against slavery. This study shows how, in the years preceding the Berlin Conference, de Laveleye got actively involved in a carefully orchestrated European media campaign in support of Leopold’s initiative. It was there that his intellectual circle became extremely useful and was fully implicated. His contacts in the world of law, especially among experts of international law, contributed to the important discussions about Congo’s juridical status. De Laveleye’s colleague Sir Travers Twiss, one of the most reputed jurists of that time, as well as the influential Institut de Droit international, of which de Laveleye had been one of the founders, entered the debate zone and took positions that were favorable for Leopold’s project. With this new approach, our paper also aims to give insight in the way Leopold II transformed his own reasoning into a more authoritative set of practical standards that were shared by an intellectual elite. [less ▲]

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See detailles stéréotypes sexués à l'adolescence et les enjeux scolaires
Gavray, Claire ULg

Conference (2010, May 19)

Detailed reference viewed: 15 (2 ULg)
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See detailConclusions : à quelles conditions pouvons-nous travailler ensemble?
Dozo, Björn-Olav ULg; Clavert, Frédéric

Conference (2010, May 19)

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See detailPerte et ressources dans les nouvelles familles: le cas des familles recomposées
D'Amore, Salvatore ULg; Gresse, Karin; Pauss, Véronique

Conference (2010, May 19)

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See detailComputational study of the error distribution in right-censored and selection-biased regression models
Laurent, Géraldine ULg; Heuchenne, Cédric ULg

Conference (2010, May 18)

Consider the regression model Y = m(X) + σ(X) Ɛ where m(X) =E [Y|X] and σ²(X) = Var [Y|X] are unknown smooth functions and the error Ɛ, with unknown distribution, is independent of X. The pair (X,Y) is ... [more ▼]

Consider the regression model Y = m(X) + σ(X) Ɛ where m(X) =E [Y|X] and σ²(X) = Var [Y|X] are unknown smooth functions and the error Ɛ, with unknown distribution, is independent of X. The pair (X,Y) is subject to generalized selection bias and the response to right censoring. We construct a new estimator for the cumulative distribution function of the error Ɛ, and develop a bootstrap technique to select the smoothing parameter involved in the procedure. The estimator is studied via extended simulations and applied to real unemployment data. [less ▲]

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See detailThe partial proportional odds model in the analysis of
Donneau, Anne-Françoise ULg

Conference (2010, May 18)

Detailed reference viewed: 15 (1 ULg)
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See detailStructuring effects of different lecithins on palm oil-based blends
Danthine, Sabine ULg; Delacharlerie, Sophie ULg; Flöter, Eckhard

Conference (2010, May 18)

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See detailThe occurrence of multicolored ladybird, Harmonia axyridis Pallas, a biological control agent in agroecosystems in Wallonia
Vandereycken, Axel ULg; Durieux, Delphine ULg; Haubruge, Eric ULg et al

Conference (2010, May 18)

The Asian ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was imported in 1997 in Belgium to control aphid populations in greenhouses. It took only few years to the insect to get adapted ... [more ▼]

The Asian ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was imported in 1997 in Belgium to control aphid populations in greenhouses. It took only few years to the insect to get adapted to temperate climate conditions and to spread out all over Europe. Now, H. axyridis is one of the coccinellid with the biggest size in Belgium, causing damages to the ecosystems through e.g. intraguild predation (IGP). We are still lacking information about the consequences of the introduction of this superpredator in our agro-ecosystems. This work focuses on the potential impacts of H. axyridis on the entomofauna associated with several crops (potatos, corn, wheat, broad bean). We evaluated in 2009 the occurrence as well as the interactions between aphids and their natural enemies (hoverflies, coccinellids and lacewings) in several agro-ecosystem sites in northern Wallonia. After one year of field observations, were found thirteen coccinellid species, most of the catched individuals being H. axyridis with 64% of the coccinellids, Propylea 14-punctata, 15%, or Coccinella 7-punctata, 14%. This invasive ladybird dominates the group of coccinellids generally in all crops in north Wallonia. The results with the sticky traps show that the maximum occurrence of H. axyridis in crops is observed in chicory, sugar beet and potatoes. The relationship aphid-ladybird in wheat for example, brings out that increase of density of Asian ladybird in mid-July follow the increase of aphids (Sitobion avenae, Sitobion fragariae, Metopolophium dirhodum, Aphis fabae) in the end of June. We also observe that, in most agro-ecosystems, hoverflies and lacewings are the dominant aphid natural enemies. In all crops investigate, the multicolored ladybird occurs with 5% of the aphidophagous after the Chrysopidae, 12% and the Syrphidae, 76%. In 2009, the agro-ecosystems with the most aphidophagous species are carrot and broad bean and these habitats are dominated by hoverflies. [less ▲]

Detailed reference viewed: 35 (7 ULg)
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See detailThe modified Reyment's multivariate coefficient of variation
Zhang, Lixin ULg

Conference (2010, May 18)

Detailed reference viewed: 38 (9 ULg)
See detailA l’interface de l’humain et du non-humain : apprendre à être affecté.
Strivay, Lucienne ULg

Conference (2010, May 18)

Detailed reference viewed: 59 (15 ULg)
See detailJupiter's and Saturn's auroras as observed by the Hubble Space Telescope
Nichols, J. D.; Grodent, Denis ULg

Conference (2010, May 17)

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See detailAccompagner une réforme vers des programmes visant le développement de compétences – difficultés et leviers –
Poumay, Marianne ULg; Tardif, Jacques

Conference (2010, May 17)

En 2007, au sein de l’Université de Liège, l’IFRES a lancé un programme interne de financement et d’accompagnement de projets facultaires. Dans les projets sélectionnés, les enseignants s’engageaient à ... [more ▼]

En 2007, au sein de l’Université de Liège, l’IFRES a lancé un programme interne de financement et d’accompagnement de projets facultaires. Dans les projets sélectionnés, les enseignants s’engageaient à progresser concrètement dans l’opérationnalisation de formations orientées vers le développement de compétences chez leurs étudiants. A travers ce programme « compétences », l’objectif de l’IFRES était d’amorcer des réformes qui visent l’amélioration de l’apprentissage des étudiants. Suite à la nécessaire description de l’initiative et de quelques résultats concrets, le présent article mentionne brièvement les difficultés d’ordre institutionnel ou organisationnel et s’attarde surtout à déterminer et illustrer des problèmes conceptuels qui se posent dans ce type de réforme. Il mentionne certains freins et facteurs facilitateurs, soulignant entre autres l’intérêt d’un accompagnement semi-collectif par un consultant externe (en l’occurrence Jacques Tardif) et d’une large communication sur les avancées des projets en cours. [less ▲]

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See detail3D Modelling of the Black Sea northwestern Shelf Ecosystem
Capet, Arthur ULg; Grégoire, Marilaure ULg

Conference (2010, May 14)

Some validation procedures are presented concerning the physicis and the biology, as well as the decomposition of the oxygen cycle in its different components. The role of the Sevastopol eddy of retaining ... [more ▼]

Some validation procedures are presented concerning the physicis and the biology, as well as the decomposition of the oxygen cycle in its different components. The role of the Sevastopol eddy of retaining POM in the Crimea peninsula causing intense bacterial oxygen consumption is evidenced. [less ▲]

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See detailAdolescence et délinquances : quand la puberté s’en mêle …De l’intérêt d’une approche biopsychosociale de la délinquance adolescentaire
Glowacz, Fabienne ULg

Conference (2010, May 13)

De nombreuses recherches (Kaltiala-Heino et al., 2003 ; Parent et al., 2003 ; Beaver § Wright, 2005 ; Haynie § Piquero 2006 ; Lynne et al., 2007,..) ont établi ces dernières années un lien entre le ... [more ▼]

De nombreuses recherches (Kaltiala-Heino et al., 2003 ; Parent et al., 2003 ; Beaver § Wright, 2005 ; Haynie § Piquero 2006 ; Lynne et al., 2007,..) ont établi ces dernières années un lien entre le développement pubertaire et l’engagement à l’adolescence dans des comportements délictueux, usage de drogue, conduites sexuelles et autres comportements exploratoires et déviants. Felson et Haynie (2002) affirment que le développement pubertaire a des effets sur différents types de délinquance comparables à d’autres puissants prédicteurs de la délinquance. Bien que l’étude de Williams et Dunlop (1999) constate que les garçons à maturité précoce et tardive présentent des taux plus élevés de délinquance que leurs pairs à maturation normale, des recherches plus récentes (Ge et al., 2002 ; Beaver § Wright, 2005 ; Michaud et al., 2006 ; Lynne et al., 2007…) soutiennent l’hypothèse de la précocité pubertaire en tant que facteur de risque : les garçons à puberté précoce ont un plus haut niveau d’engagement dans des comportements délinquants et agressifs, alors que les garçons à puberté tardive s’engagent dans moins de délinquances (de type crime, violence, atteintes aux biens, usage de drogue). La délinquance sexuelle juvénile, au croisement de la délinquance et de la sexualité, incite à un questionnement sur les effets de la puberté au niveau des conduites sexuelles déviantes. Notre recherche « Adolescence, délinquances et processus pubertaire » portant sur un échantillon de 316 adolescents âgés de 13 à 18 ans, a notamment évalué l’incidence du timing pubertaire au niveau de l’adoption de conduites délinquantes sexuelles et non sexuelles. Nos résultats confirment la pertinence de la prise en compte du développement pubertaire dans les processus de socialisation et d’engagement dans la délinquance générale et/ou sexuelle à l’adolescence. [less ▲]

Detailed reference viewed: 132 (17 ULg)
See detailA paleolimnological study of Lake Kivu (East Africa)
Knops, Sébastien; Darchambeau, François ULg; Verleyen, Elie et al

Conference (2010, May 13)

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See detailvandaliser à l'adolescence
Gavray, Claire ULg; vettenburg, Nicole

Conference (2010, May 13)

The personal factor which explain vandalism amongst adolescents differ according to gender group. In the male group, we find an important impact of the valuation of violence and of the feeling of social ... [more ▼]

The personal factor which explain vandalism amongst adolescents differ according to gender group. In the male group, we find an important impact of the valuation of violence and of the feeling of social and statutory victimisation. In the female group, we find track of early victimisation in the family and the other spheres. [less ▲]

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See detailQualité de vie en oncologie pédiatrique : analyse comparative d’enfants en et hors traitements au moyen d’un outil modulaire
Missotten, Pierre ULg; Dupuis, Gilles; Hoyoux, Claire et al

Conference (2010, May 12)

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See detailAbsorbing layers for shallow water models
Modave, Axel ULg; Deleersnijder, Eric; Delhez, Eric ULg

Conference (2010, May 11)

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See detailL’utilisation de la carte mentale en science politique : pertinence et limites
Breux, Sandra; Reuchamps, Min ULg; Loiseau, Hugo

Conference (2010, May 10)

In this presentation, we offer insight about the use of mental map in political science

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See detailDe Paepe-Willems Award 2010: Optimization and analysis of lock gates in the framework of the Seine-Escaut Est waterway upgrading
Gernay, Thomas ULg

Conference (2010, May 10)

This paper presents a research study performed lock gates. It concerns the downstream lock gates of the one of the four new locks planned within the framework of the “Seine-Escaut Est (SEE)” project in ... [more ▼]

This paper presents a research study performed lock gates. It concerns the downstream lock gates of the one of the four new locks planned within the framework of the “Seine-Escaut Est (SEE)” project in the Walloon Region of Belgium. At the stage of the basic preliminary design, it was decided to use four identical gates, all suspended and manoeuvred by lateral movement. On this basis, the present work tackles with different aspects of the lock gate study. The aim is double: on one hand, to advance in the study of the solution of the four downstream lock gates of the SEE project, and the other hand, to concentrate more particularly on the lock gate analysis, among which their design, optimization and structural behavior in the case of ship impact. We began with the design and optimization of the gate. This work was realized with the LBR5 lock gate optimization software, according to a method comparing a representative number of optimized solutions considering at the same time the cost and weight aspects of the structure. This method leaded to an optimized solution of the downstream gate on which further studies are concentrated. Indeed this optimized gate was modeled with the non linear finite elements software FINELG. This program was used to conduct a non linear numerical analysis of the effect of a boat impact on the downstream gate. Several analyses were performed that allowed us to discuss on the influence of the stiffener dimensions and the influence of the impact zone on the gate structural behavior submitted to the impact. Two different behaviors have been brought to light, a ductile one and a fragile one. The results of the numerical analysis with finite elements have underlined the importance of the development of a global plastic mechanism with the purpose of dissipating a large amount of energy. Finally, we have used an analytical model to calculate the gate theoretical strength in a case of a ship impact, and to compare this value with the FEM numerical analysis results. [less ▲]

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See detail« Dessinez la Belgique » : une approche par carte mentale du fédéralisme belge
Flaba, Elodie ULg; Grandjean, Geoffrey ULg; Reuchamps, Min ULg

Conference (2010, May 10)

In this communication, we present how useful can mental maps be in political science through the example of the research "Draw Belgium".

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See detailVers un apprentissage subquadratique pour les mélanges d’arbres
Schnitzler, François ULg; Leray, Philippe; Wehenkel, Louis ULg

Conference (2010, May 10)

We consider randomization schemes of the Chow-Liu algorithm from weak (bagging, of quadratic complexity) to strong ones (full random sampling, of linear complexity), for learn- ing probability density ... [more ▼]

We consider randomization schemes of the Chow-Liu algorithm from weak (bagging, of quadratic complexity) to strong ones (full random sampling, of linear complexity), for learn- ing probability density models in the form of mixtures of Markov trees. Our empirical study on high-dimensional synthetic problems shows that, while bagging is the most accurate scheme on average, some of the stronger randomizations remain very competitive in terms of accuracy, specially for small sample sizes. [less ▲]

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See detailLe(s) génocide(s) vu(s) par des jeunes : représentations et localisations
Grandjean, Geoffrey ULg

Conference (2010, May 10)

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See detailPoor managerial competences: three typical failure patterns for small firms
Crutzen, Nathalie ULg; Van Caillie, Didier ULg

Conference (2010, May 10)

After an in-depth review of the scientific literature dedicated to (small) business failure causes (Crutzen and Van Caillie, 2008), it comes out that mismanagement is, by far, the failure cause which is ... [more ▼]

After an in-depth review of the scientific literature dedicated to (small) business failure causes (Crutzen and Van Caillie, 2008), it comes out that mismanagement is, by far, the failure cause which is the most commonly evoked by previous researchers (Argenti, 1976; Wichman, 1983; Newton, 1985; O'Neill and Duker, 1986; Thornhill and Amit, 2003). Nevertheless, the concept of « mismanagement » is relatively vague and large (Bruno et al., 1987; Sheldon, 1994). It is thus now necessary to clarify it if one wants to better understand the causes of small business failure and, in fine, to better prevent this phenomenon (Argenti, 1976). In particular, it is essential to distinguish between the main categories of managerial problems small businesses can be faced to in order to be able to better anticipate their failure (thanks to adequate trainings, for example) and in order to propose adequate remedies to specific managerial problems small distressed firms are confronted to. In this context, the current article identifies, on the basis of two complementary statistical analyses, three specific patterns for badly-managed firms, amongst a sample of 91 small distressed firms. [less ▲]

Detailed reference viewed: 93 (15 ULg)
See detailLe ralentissement de la progression de l'insuffisance rénale chronique
Krzesinski, Jean-Marie ULg

Conference (2010, May 10)

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See detailIntérêt du trajet de soins en néphrologie
Krzesinski, Jean-Marie ULg

Conference (2010, May 09)

Detailed reference viewed: 12 (5 ULg)
See detailHypertension durant la grossesse
Krzesinski, Jean-Marie ULg

Conference (2010, May 08)

Detailed reference viewed: 13 (1 ULg)
See detailMémoire(s) en question(s) : la transmission entre monopole et concurrence
Vanesse, Marc ULg

Conference (2010, May 07)

Colloque sur les difficultés rencontrées par les scientifiques pour transmettre certains épisodes douloureux de l'histoire (Holocauste, génocides, guerres) et la concurrence qui peut exister entre ... [more ▼]

Colloque sur les difficultés rencontrées par les scientifiques pour transmettre certains épisodes douloureux de l'histoire (Holocauste, génocides, guerres) et la concurrence qui peut exister entre certains gardiens de la mémoire. [less ▲]

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See detailImpact of Greenland and Antarctic ice sheet interactions on model climate sensitivity
Goelzer, H; Huybrechts, P; Loutre, M-F et al

Conference (2010, May 07)

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See detailLa concurrence mémorielle
Grandjean, Geoffrey ULg

Conference (2010, May 07)

Detailed reference viewed: 11 (7 ULg)
See detailJoséphisme et sécularisation
Henneau, Marie-Elisabeth ULg

Conference (2010, May 07)

Detailed reference viewed: 17 (0 ULg)
See detailLe ralentissement de la progression de l'insuffisance rénale chronique
Krzesinski, Jean-Marie ULg

Conference (2010, May 06)

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See detailChallenging Combinatorial Problems
Crama, Yves ULg

Conference (2010, May 06)

Detailed reference viewed: 13 (0 ULg)
See detailMonitoring the ionospheric positioning error with a GNSS dense network
Wautelet, Gilles ULg; Lejeune, Sandrine; Warnant, René ULg

Conference (2010, May 06)

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See detailAuroral footprints; everywhere
Grodent, Denis ULg; Bonfond, Bertrand ULg; Radioti, Aikaterini ULg et al

Conference (2010, May 06)

Jupiter’s moons Io, Europa and Ganymede are continuously interacting with the Jovian magnetic field and with the sheet of plasma flowing near its equatorial plane. The interaction between these moons and ... [more ▼]

Jupiter’s moons Io, Europa and Ganymede are continuously interacting with the Jovian magnetic field and with the sheet of plasma flowing near its equatorial plane. The interaction between these moons and the Jovian magnetosphere causes strong Alfvénic perturbations which propagate along the magnetic field lines. On their way towards Jupiter’s polar regions, these perturbations accelerate charged particles which then interact with Jupiter’s ionosphere where they loose a fraction of their energy in the form of auroral emissions. Each of the three moons leaves an auroral footprint around the poles of Jupiter which departs from the bulk of the auroral emission. Their location is mainly controlled by the topology of the field lines and thus analysis of the auroral footprints provides information on the magnetic field itself. In that regard, the satellites auroral footpaths were used to highlight the presence of a strong magnetic anomaly in the northern hemisphere of Jupiter. Detailed inspection of the footprints’ brightness and morphology as a function of time reveals fundamental information on the interaction mechanisms near the moons, on the particles acceleration mechanisms as well as on the Jovian ionosphere. For example, it was suggested that the Io footprint actually consists of several spots resulting from successive steps in the perturbation propagation process. Another example is the finding of three different timescales in the variations of Ganymede’s footprint; each of them is pointing to a different part of the electromagnetic interaction between the moon’s mini-magnetosphere and the Jovian plasma. Several recent images of Saturn’s auroral regions obtained with Cassini/UVIS at high latitude show an obvious auroral spot at the predicted location of Enceladus’ footprint. This major finding demonstrates that the electromagnetic interaction between a moon and its parent planet is not unique to Jupiter but appears to be a common feature in planetary systems. [less ▲]

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See detailComparison between in situ and satellite surface temperature in the Western Mediterranean Sea
Alvera Azcarate, Aïda ULg; Barth, Alexander ULg; Troupin, Charles ULg et al

Conference (2010, May 06)

A comparison between satellite and in situ sea surface temperature (SST) data in the Western Mediterranean Sea in 1999 is realised. The aim of this study is to better understand the differences between ... [more ▼]

A comparison between satellite and in situ sea surface temperature (SST) data in the Western Mediterranean Sea in 1999 is realised. The aim of this study is to better understand the differences between these two data sets, in order to realise merged maps of SST using satellite and in situ data. When merging temperature from different platforms, it is crucial to take the expected RMS error of the observations into account and to correct for possible biases. Advanced Very High Resolution Radiometer (AVHRR) SST day-time and night-time satellite data are used, and the in situ data have been obtained from various databases (World Ocean Database’05, Coriolis, Medar/Medatlas and ICES). Statistics about the differences due to the hour of the day, the month of the year, the type of sensor/platform used (CTD, XBT, drifter, etc) and the spatial distribution are made using a combination of error measures, diagrams and statistical hypothesis testing. In addition to quantify the errors between different platforms, several assumptions often made when creating gridded analyses will be critically reviewed: unbiased data sets, non-correlated errors of the observations, spatially uniform variance, and Gaussian-distributed data. [less ▲]

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See detailTraduire les effets de rupture: le style de Céline en italien
Benzoni, Pietro ULg

Conference (2010, May 06)

Detailed reference viewed: 34 (4 ULg)
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See detailDual Citizenship and Home-country Voting
Lafleur, Jean-Michel ULg

Conference (2010, May 05)

Detailed reference viewed: 26 (1 ULg)
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See detailHow do insects communicate with a cadaver?
Dekeirsschieter, Jessica ULg; Verheggen, François ULg; Frederickx, Christine ULg et al

Conference (2010, May 05)

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See detailL’édition littéraire en Belgique au passé et au présent
Durand, Pascal ULg; Habrand, Tanguy ULg

Conference (2010, May 05)

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See detailBiosensors in Forensic Sciences
Frederickx, Christine ULg; Verheggen, François ULg; Haubruge, Eric ULg

Conference (2010, May 05)

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See detailOccurrence of the multicolored ladybird, Harmonia axyridis PALLAS in Walloon agro-ecosystems
Vandereycken, Axel ULg; Durieux, Delphine ULg; Joie, Emilie ULg et al

Conference (2010, May 05)

The Asian ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was imported in 1997 in Belgium to control aphid populations in greenhouses. It took only few years to the insect to get adapted ... [more ▼]

The Asian ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was imported in 1997 in Belgium to control aphid populations in greenhouses. It took only few years to the insect to get adapted to temperate climate conditions and to spread out all over Europe. Now, H. axyridis is one of the coccinellid with the biggest size in Belgium, causing damages to the ecosystems through e.g. intraguild predation (IGP). We are still lacking information about the consequences of the introduction of this superpredator in our agro-ecosystems. This work focuses on the potential impacts of H. axyridis on the entomofauna associated with several crops (potatos, corn, wheat, broad bean). We evaluated in 2009 the occurrence as well as the interactions between aphids and their natural enemies (hoverflies, coccinellids and lacewings) in several agro-ecosystem sites in northern Wallonia. After one year of field observations, were found thirteen coccinellid species, most of the catched individuals being H. axyridis with 64% of the coccinellids, Propylea 14-punctata, 15%, or Coccinella 7-punctata, 14%. This invasive ladybird dominates the group of coccinellids generally in all crops in north Wallonia. The results with the sticky traps show that the maximum occurrence of H. axyridis in crops is observed in chicory, sugar beet and potatoes. The relationship aphid-ladybird in wheat for example, brings out that increase of density of Asian ladybird in mid-July follow the increase of aphids (Sitobion avenae, Sitobion fragariae, Metopolophium dirhodum, Aphis fabae) in the end of June. We also observe that, in most agro-ecosystems, hoverflies and lacewings are the dominant aphid natural enemies. In all crops investigate, the multicolored ladybird occurs with 5% of the aphidophagous after the Chrysopidae, 12% and the Syrphidae, 76%. In 2009, the agro-ecosystems with the most aphidophagous species are carrot and broad bean and these habitats are dominated by hoverflies. [less ▲]

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See detailThe chemical ecology of ladybird beetles
Durieux, Delphine ULg; Verheggen, François ULg; Vandereycken, Axel ULg et al

Conference (2010, May 05)

Ladybird beetles (Coleoptera: Coccinellidae) use a wide variety of semiochemicals to communicate with each other, e.g. finding a mate, protecting themselves from predation or cannibalism, finding a ... [more ▼]

Ladybird beetles (Coleoptera: Coccinellidae) use a wide variety of semiochemicals to communicate with each other, e.g. finding a mate, protecting themselves from predation or cannibalism, finding a shelter to overwinter or ensuring a better survival for their offspring. But chemical communication upon ladybeetles has also found recently to occur with their prey, their prey-host plants and even within their interactions with their natural enemies. Thorough studies on ladybird behaviours towards these compounds could lead to their practical implementation in integrated strategies using ladybirds to control pests, like aphids or mealybugs. [less ▲]

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See detailUniversity-SME's-Government : combining energies for innovation
Morant, Michel ULg

Conference (2010, May 04)

How University can play a role in the open innovation process

Detailed reference viewed: 14 (5 ULg)
See detailSimulation of glacial-interglacial atmospheric CO2 variations using a comprehensive Earth system model of intermediate complexity
Brovkin, Victor; Ganopolski, Andrei; Calov, Reinhard et al

Conference (2010, May 04)

The mechanisms of strong glacial-interglacial variations in the atmospheric CO2 concentration and the role of CO2 in driving glacial cycles still remain debatable. Here using the model of intermediate ... [more ▼]

The mechanisms of strong glacial-interglacial variations in the atmospheric CO2 concentration and the role of CO2 in driving glacial cycles still remain debatable. Here using the model of intermediate complexity CLIMBER-2 which includes all major components of the Earth system – atmosphere, ocean, land surface, ice sheets, terrestrial biota and weathering, aeolian dust and marine biogeochemistry – we performed simulation of the last glacial cycle using variations in the Earth’s orbital parameters as the only prescribed climatic forcing. The model simulates rather realistically temporal and spatial dynamics of the Northern Hemisphere glaciation and temporal dynamics of the atmospheric CO2 concentration. During the glacial inception, the model is able to simulate a decrease in the atmospheric CO2, despite of release of terrestrial biosphere carbon. The drop in CO2 concentration during the first part of the glacial cycle is between 20 and 40 ppmv. It is related primarily to the physical mechanisms – increase of the ocean solubility and relative volume and the age of the Antarctic bottom water masses. The latter is related to increased sea ice formation in the Southern Ocean and lowering of the surface salinity in the northern North Atlantic. During the second part of the glacial cycle, the atmospheric CO2 concentration decreases towards the level of 200 ppmv. A part of this drop is due an increase of biological productivity in the Southern Ocean which is directly related in the CLIMBER-2 model to increase of aeolian dust supply into the Southern Hemisphere via the iron fertilization mechanism. Significant part of the decreasing CO2 trend is also explained by increased weathering on land, especially on the exposed tropical shelves. A decrease in shallow water carbonate sedimentation and shift of CaCO3 sedimentation towards the deep ocean also plays important role in CO2 decrease. With the onset of the glacial termination, initial rise in the atmospheric CO2 concentration is explained by a weakening of the Atlantic thermohaline circulation due to increased freshwater input into the northern North Atlantic. The model is able to simulate the return of CO2 concentration to its interglacial value after termination of the glacial cycle but simulated CO2 concentration still lags considerably behind the ice core reconstructions. [less ▲]

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See detailThe Rain Ratio Hypothesis: Can it be Rescued?
Munhoven, Guy ULg

Conference (2010, May 04)

The Rain Ratio Hypothesis (Archer and Maier-Reimer, 1994, Nature 367, 260–263) ascribes an important part of the observed glacial-interglacial variations of CO2 in the atmosphere to reduced sea-floor rain ... [more ▼]

The Rain Ratio Hypothesis (Archer and Maier-Reimer, 1994, Nature 367, 260–263) ascribes an important part of the observed glacial-interglacial variations of CO2 in the atmosphere to reduced sea-floor rain ratio (i.e., carbonate-C/organic-C in the biogenic particle flux at the sea-floor) during glacial times. With a lower sea-floor rain ratio the influence of organic carbon respiration on carbonate dissolution is stronger. The deep-sea carbonate ion concentration required for global ocean carbonate compensation will then be higher, which in turn contributes to lower atmospheric pCO2. Munhoven (2007, Deep-Sea Research II, 722–746) showed that the suggested rain ratio reductions lead to unrealistic sedimentary records for %CaCO3: the transition zone changes in the model sedimentary record were too large and opposite in phase to available observational data. The rain ratio reduction applied by Munhoven (2007) was uniform over the ocean and the author hypothesised that a non-uniform reduction could change the complete picture. If the rain ratio variations had primarily taken place in open ocean areas of great depth—essentially in regions where the sea floor was deeper than the saturation horizon or the CCD—then the transition zone boundaries could possibly have moved less. Here, we test this hypothesis and analyse the effect of depth dependent variations. It is shown that concentrating rain ratio changes over areas of greatest water depth completely alters the sedimentary imprint: the phase relationship of the signal reverts (compared to the uniform case) and the amplitude of the change decreases, bringing it into better agreement with the observations. However, the pCO2 response is also reduced. The global average rain ratio reduction of 40% that yielded a 40 ppm reduction of atmospheric pCO2 in the uniform case only leads to 25 ppm in this non-uniform case. Results for other depth-dependent reductions will also be discussed. [less ▲]

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See detailBiodegradable microbeads based on poly(L-lactide) as microcarriers for tissue engineering
Tsoy, A.M; Köttgen, Cindy; Grandfils, Christian ULg et al

Conference (2010, May 03)

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See detailTowards a comprehensive C-budgeting approach of a cocoliothophorid bloom in the northern Bay of Biscay: results from PEACE project.
Harlay, Jérôme ULg; Borges, Alberto ULg; Delille, Bruno ULg et al

Conference (2010, May 03)

During coccolithophorid blooms, carbon (C) cycling in the photic zone is driven by the production and the degradation of organic matter (primary production and community respiration), as well as the ... [more ▼]

During coccolithophorid blooms, carbon (C) cycling in the photic zone is driven by the production and the degradation of organic matter (primary production and community respiration), as well as the production and the dissolution of biogenic calcium carbonate (CaCO3). Organic and inorganic metabolisms lead to a transfer of carbon to depth and both impact the flows of carbon dioxide (CO2) in the water column and the CO2 flux across the air-sea interface. Furthermore, due to complex dynamics of coccolithophores, the impact of metabolic C fluxes on CO2 fluxes is variable in time, depending on the stage of the bloom development, and mainly on the ratio of calcification to primary production (CAL:GPP). Understanding and quantifying C cycling of coccolithophorid blooms in natural conditions is a prerequisite to correctly validate biogeochemical models aiming at predicting feedbacks related to ocean acidification, which incorporate knowledge obtained from perturbation laboratory experiments. We carried out a trans-disciplinary cruise on board the R/V Belgica at the continental margin of the Bay of Biscay, in the midst of a coccolithophorid bloom, during which 14C primary production (GPPp), 14C calcification (CAL) and O2-based pelagic community respiration rates (PCR) were determined in the water column. [less ▲]

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See detailAuroral footprints of tail reconnection at Jupiter and Saturn
Radioti, Aikaterini ULg; Grodent, Denis ULg; Gérard, Jean-Claude ULg et al

Conference (2010, May 03)

Tail reconnection at Jupiter’s magnetosphere, has recently been shown to leave its signature in the aurora. The Hubble Space Telescope observed transient polar dawn spots on the Jovian aurora, with a ... [more ▼]

Tail reconnection at Jupiter’s magnetosphere, has recently been shown to leave its signature in the aurora. The Hubble Space Telescope observed transient polar dawn spots on the Jovian aurora, with a characteristic recurrence period of 2-3 days. Because of their periodic occurrence cycle and observed location, it is suggested that the transient auroral features are related to the precipitated, heated plasma during reconnection processes taking place in the Jovian magnetotail. Particularly, it is proposed that the transient auroral spots are triggered by the planetward moving flow bursts released during the process. A comparison of their properties with those of the <br />auroral spots strengthen the conclusion that they are signatures of tail reconnection. <br />Cassini recently revealed magnetotail reconnection events at Saturn similar to those observed at Jupiter. Based on the UVIS dataset we present transient features at Saturn’s polar auroral region, which are possible signatures of tail reconnection. We study their size, power, duration and duty cycle and we suggest possible triggering mechanisms associated with magnetotail dynamics. We compare these auroral emissions with those at Jupiter and we discuss how energy is transferred to the ionosphere during tail reconnection. [less ▲]

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See detailParticle export with coccolithophorid Emiliania huxleyi blooms in the Bay of Biscay. XII International Symposium on Oceanography of the Bay of Biscay
Schmidt, Sabine; Harlay, Jérôme ULg; Roevros, Nathalie et al

Conference (2010, May 03)

Coccolithophores, one of the most productive calcifying phytoplanktonic groups, often form massive blooms in the temperate and sub-polar oceans, and in particular at continental margins and in shelf seas ... [more ▼]

Coccolithophores, one of the most productive calcifying phytoplanktonic groups, often form massive blooms in the temperate and sub-polar oceans, and in particular at continental margins and in shelf seas. Export of organic carbon and calcification are the main drivers of the biological CO2 pump and are expected to change with oceanic acidification. Coccolithophores are also a major producer of dimethyl sulphide (DMS), whose oxidation products of DMS affect the number and size distribution of tropospheric cloud condensation nuclei, with possible consequences for cloud albedo and heat balance. Coccolithophores are further known to produce transparent exopolymer particles (TEP) that promote particle aggregation and sinking. Coccolithophores play thus key roles in the global carbon, carbonate and sulphur cycles, and, in turn, in climate regulation. The objectives of the Belgian CCCC project (Role of Oceanic Production and Dissolution of Calcium Carbonate in Climate Change) was to evaluate the role in climate regulation of calcification, primary production and export processes during coccolithophorid blooms. Field investigations, supported by remote sensing data, were conducted in the Northern Gulf of Biscay on the continental shelf and slope region (47°- 50°30'N, 5°-11°W) where coccolithophorid blooms are frequently and recurrently observed. During the cruises in May 2002 and 2003 on board the r/v Belgica, fundamental variables (temperature, salinity, primary production, Chl. a, particulate organic carbon) were measured in the water column. To estimate the spatial variability of particle dynamics in surface waters in relation with the coccolithophorid bloom development, we had employed the natural radionuclide 234Th. The preferential scavenging of the particle-reactive daughter 234Th (t1/2= 24.1 days) while its soluble parent, 238U, remains nearly constant, provides an appropriate tool for assessing temporal variations of the removal of particles from surface waters, at a time scale of weeks. The two cruises have permitted to sample two different situations; in particular in May 2002, it was possible to sample a well-developed bloom. As a result, 234Th present contrasted profiles in the upper 0-80 m during the two investigations. In May 2003, 234Th was nearly in equilibrium with 238U (its radioactive parent) along with high particulate activities: this seems to indicate an early bloom situation with low grazing fluxes. On the opposite, in May 2002, deficits of 234Th toward 238U were indicating more efficient particle export from upper waters. Synthesis of the acquired data will be discussed to compare particle dynamics and the magnitude of particulate carbon export using 234Th and POC data at different states of coccolithophorid bloom in the Northern Gulf of Biscay. [less ▲]

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See detailBiodegradable microcarriers with entrapped peptides for tissue engineering
Markvicheva, E; Prudchenko, I; Tsoy, A et al

Conference (2010, May 03)

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See detailAn evaluation of the contributions of the distant and near-Earth neutral lines to magnetotail reconnection rates and magnetic flux closure
Milan, Steve; Boakes, Peter; Imber, Suzanne et al

Conference (2010, May 01)

The expanding-contracting polar cap paradigm relates the dayside and nightside rates of magnetic reconnection to changes in the size of the ionospheric polar cap, the amount of magnetic flux in the ... [more ▼]

The expanding-contracting polar cap paradigm relates the dayside and nightside rates of magnetic reconnection to changes in the size of the ionospheric polar cap, the amount of magnetic flux in the magnetotail lobes, and the excitation of ionospheric and magnetospheric plasma convection. Expansions of the polar cap are the consequence of dayside reconnection, the merging of interplanetary magnetic flux with the terrestrial dipole to increase the proportion of the dipole that is open. Contractions of the polar cap are caused by magnetic reconnection in the magnetotail at a distant neutral (or X-) line (DXL) and near-Earth neutral line (NEXL), the latter especially during substorms, to reduce the open flux in the magnetosphere. There is debate surrounding the proportion of flux closure provided by the DXL and NEXL, and hence whether substorms dominate the nightside contribution to ionospheric and magnetospheric convection. This study utilizes a 7-day interval of auroral observations from the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) satellite and convection measurements by the Super Dual Auroral Radar Network (SuperDARN) to quantify the nightside rates of reconnection during substorm and non-substorm periods and hence investigate DXL and NEXL flux closure. [less ▲]

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See detailMicrowave-assisted conversion of carbohydrates. State of the art and outlook.
Richel, Aurore ULg; Laurent, Pascal ULg; Wathelet, Bernard ULg et al

Conference (2010, May)

The valorisation of carbohydrates arising from the hydrolysis of renewable feedstocks (i.e. lignocellulosic biomass) is nowadays an area of outmost interest. In this context, the implementation of fast ... [more ▼]

The valorisation of carbohydrates arising from the hydrolysis of renewable feedstocks (i.e. lignocellulosic biomass) is nowadays an area of outmost interest. In this context, the implementation of fast, expeditous and cost-effective methodologies for the modification of these naturally occurring compounds is becoming a prerequisite. In this sense, the application of microwaves has gained progressive attention in laboratories for making a range of high-added value sugars derivatives scaffolds. Its advantages are numerous and include enhacement of reaction rates and yields combined to improved regio-, chemo- and anomeric selectivities. Since the first publications of Gedye et Giguere in 1986, the use of microwave has progressively emerged as a popular non conventional heating source in the field of organic synthesis.1 Nevertheless, its application in the area of carbohydrate chemistry is less documented.2, 3 Although research in this field is still in its infancy, recourse to microwaves often provides, with remarkable yields and atom efficiency, new carbohydrate-based structures that are not easily available by any another means (or only via painstaking multi-step protocols). This communication proposes therefore selected, recent and non exhaustive illustrations of the application of microwaves to promote famous carbohydrates “model” reactions. The scale-up of such microwave-assisted reactions is also presented. [less ▲]

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See detailHow to construct fundamental risk factors?
Lambert, Marie ULg; Hübner, Georges ULg

Conference (2010, May)

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See detailTime integration of finite rotations in flexible multibody dynamics using Lie group integrators
Bruls, Olivier ULg; Cardona, Alberto

Conference (2010, May)

Detailed reference viewed: 14 (2 ULg)
See detailPenser la justice en contextes islamiques
Nachi, Mohamed ULg

Conference (2010, May)

Inscrire la question de la justice dans les contextes des sociétés islamiques pour en montrer la spécificités et les différentes dimensions sociales, culturelles, politiques, éthiques, etc.

Detailed reference viewed: 18 (0 ULg)
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See detailBayesian hierarchical linear regression for the validation of analytical methods
Lebrun, Pierre ULg; Boulanger, Bruno ULg; Rozet, Eric ULg et al

Conference (2010, May)

Analytical quantitative methods are widely used to quantify analytes of interest, for instance in pharmaceutical formulations, linking an observed response to the concentration of one compound of the ... [more ▼]

Analytical quantitative methods are widely used to quantify analytes of interest, for instance in pharmaceutical formulations, linking an observed response to the concentration of one compound of the formulation. Current methodologies to validate these analytical methods are based on one-way ANOVA random effect model in order to estimate repeatability and intermediate precision variances. This model is then applied several times at different concentration levels over a range of concentrations where the method is intended to be used, assuming independency between the levels. In this way, the capacity of the method to be able to quantify accurately is assessed at various concentration levels, and the method is said to be fitted for purpose (or valid) at the concentration level(s) where it shows trueness and precision that are fully acceptable, i.e. within predefined acceptance limits. Problem of such approach is the amount of data required and the time needed to collect them, while small sample sizes (small number of series and of replicates per series) are often preferred and practiced by laboratories. A better use of the data could then be envisaged. In this presentation, we take into account the response-concentration relationship that exists by the use of a hierarchical linear regression model. Instead of fitting a model at each concentration level that is assessed, only one model is studied. We show how the Bayesian framework is well adapted to this task. Also, as a predictive tool, we naturally derive beta-expectation and beta-gamma content tolerance intervals by means of MCMC simulations. The Bayesian modeling can also include informative prior information whenever justified, leading to reliable decisions given the domain knowledge. [less ▲]

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See detailMultiparametric observations and analysis in the Bay of Calvi (Corsica), an ideal site for studying the human activity effects and climate changes in the Mediterranean Sea; STARESO
Gobert, Sylvie ULg; Alvera Azcarate, Aïda ULg; Barth, Alexander ULg et al

Conference (2010, May)

STARESO (Station de REcherche Sous marine et Océanographique) is the marine and oceanographic research station of the University of Liège (Belgium) managed by the French company STARESO S.A.. Constructed ... [more ▼]

STARESO (Station de REcherche Sous marine et Océanographique) is the marine and oceanographic research station of the University of Liège (Belgium) managed by the French company STARESO S.A.. Constructed in 1969, it is located near Calvi (Corsica, Western Mediterranean Sea) in an oligotrophic area chosen for the exceptional quality of its coastal waters STARESO offers to the oceanographers, by diving or with boats, a direct access to the sea. The variety of the accessible ecosystems is remarkable and unique in the Mediterranean basin: -the Bay of Calvi is characterized by healthy and very diverse biocenosis (e.g. Posidonia meadows, rocky and sandy communities, -a steep submarine canyon, with depths greater than 1 000 meters, is accessible in 15 minutes of navigation; -the Liguro-Provençal front, a major hydrologic structure, is situated between 10 and 15 miles of the coast. STARESO is accessible all the year for everybody and is functioning like an oceanographic research vessel. The Station is a platform for all oceanographic disciplines with a scientific expertise widely based on a long tradition of interdisciplinary work, and a direct access to time series of physical, chemical and biological data registered with automated systems and variety of sensors deployed in the Bay of Calvi since 30 years. This platform provides the opportunity to reach coastal, pelagic, benthic, deep systems with a manageable cost and ship requirements in a pristine zone. [less ▲]

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See detailL'enlèvement international d'enfants- questions choisies
Pfeiff, Silvia ULg

Conference (2010, May)

Detailed reference viewed: 45 (19 ULg)
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See detailThe assessment of the past decades based on modelling and data analysis: some examples
Grégoire, Marilaure ULg; Gorsky, G.; Sesame participants, .

Conference (2010, May)

Detailed reference viewed: 2 (0 ULg)
See detailEarth and sea-level change projections with the Earth system model of intermediate complexity LOVECLIM
Goelzer, H.; Huybrechts, P.; Loutre, M. F. et al

Conference (2010, May)

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See detailIn silico study of the interaction of the Myelin Basic Protein C-terminal a-helical peptide with DMPC and mixed DMPC/DMPE lipid bilayers
Bessonov, Kyrylo ULg

Conference (2010, May)

Biological membranes continue to be extensively investigated in different ways. This paper presents the benefits of Molecular Dynamics (MD) approaches to study the properties of biological membranes and ... [more ▼]

Biological membranes continue to be extensively investigated in different ways. This paper presents the benefits of Molecular Dynamics (MD) approaches to study the properties of biological membranes and proteins using the freely available GROMACS package, in the context of the Myelin Basic Protein (MBP) C-terminal a-helical peptide. A mixed membrane consisting of 2-Dimyristoyl-sn-Glycero-3-phosphocholine/1,2-Dimyristoyl-sn-Glycero-3- phosphoethanolamine (DMPC/DMPE), and pure DMPC membranes, composed of 188 and 248 lipids, respectively, were simulated for 200 ns at 309 K. The DMPC membrane was approximately three times more fluid compared to the DMPC/DMPE system, with the diffusion coefficients (D) being 0.0207x10-5 cm2/s and 0.0068x10-5 cm2/s, respectively. In addition, the 14-residue peptide representing the C-terminal a-helical region of murine Myelin Basic Protein (MBP), with amino acid sequence NH2-A141YDAQGTLSKIFKL154-COOH , was simulated in both membrane systems for 200 ns. The peptide penetrated further into the DMPC bilayer compared to the mixed DMPC/DMPE bilayer, potentially because of the reduced accessibility of the charged peptide amino acid side chains to the formal positive charge of the amine N atom surrounded by methyl and methylene groups in DMPC, that might have resulted in greater overall peptide mobility [3]. These findings are significant in their implication that membrane composition affects the behavior of MBP, providing further insights into myelin structure. Our preliminary results suggest that local changes in membrane composition (e.g. enrichment in DMPE molecules), as well as, electrostatic nature of primary amino acid sequence could cause localized denaturation / instability of external MBP a-helices possibly augmenting the degradation of myelin in multiple sclerosis (MS), resulting in a subsequent decrease of nerve impulse propagation efficiency. [less ▲]

Detailed reference viewed: 42 (7 ULg)