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See detailHeat Pumping and Reversible Air Conditioning - First Case Study Results
Aparecida Silva, Cleide; Bertagnolio, Stéphane ULg; Hannay, Jules et al

Conference (2007, April)

Detailed reference viewed: 66 (4 ULg)
See detailEffect of CO2 concentration on suspended particle dynamics during a mesocosm bloom experiment (Peece II)
Engel, Anja; Bellerby, R.; Delille, Bruno ULg et al

Conference (2007, April)

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailWheat starch variability in characteristics and rheological properties : the influence of varieties harvest years and phytotechnique.
Sinnaeve, Georges; Paridaens, A.-M.; Massaux, Carine et al

Conference (2007, April)

Detailed reference viewed: 4 (2 ULg)
See detailSpring CO2 dynamics within sea ice: abiotical versus biological control.
Delille, Bruno ULg; Borges, Alberto ULg; Lannuzel, Delphine et al

Conference (2007, April)

Detailed reference viewed: 7 (0 ULg)
See detailSimulation of annual cycles of phytoplankton, zooplankton and nutrients to the South of Gran Canaria
Troupin, Charles ULg; Sangrà, Pablo; Arístegui, Javier

Conference (2007, March 28)

Detailed reference viewed: 15 (0 ULg)
See detailAdministrateur central et fonctions exécutives
Collette, Fabienne ULg

Conference (2007, March 27)

Detailed reference viewed: 18 (4 ULg)
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See detailEquations for GFR estimation: application and limits
Cavalier, Etienne ULg; Delanaye, Pierre ULg

Conference (2007, March 24)

Detailed reference viewed: 6 (1 ULg)
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See detailMDRD equation for GFR estimation : analytical limitations
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Krzesinski, Jean-Marie ULg et al

Conference (2007, March 23)

Detailed reference viewed: 110 (1 ULg)
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See detailRédiger en anglais : l’utilisation de templates
Reuchamps, Min ULg

Conference (2007, March 23)

In this paper, I argue that writing in English – for non-native – can be eased by the use of templates. Templates are pre-formatted and reusable models prepared by the author following proper publications ... [more ▼]

In this paper, I argue that writing in English – for non-native – can be eased by the use of templates. Templates are pre-formatted and reusable models prepared by the author following proper publications according to the purpose of the writing. The use of templates offers at least three advantages: first, easing the writing since it follows a pre-formatted model; second, giving to the text a more English touch; third, increasing the chances of publication since it follows models which have been published. This technique works particularly well for short texts (for instance, abstracts, short papers or book reviews). Yet, templates are only a tool amongst other and should be used with these tools. Furthermore, they limit one’s creativity and enclose the author in a pre-formatted structure. Above all, to some extent, templates reflect the way of thinking and writing shared by the Anglo-Saxon academia. [less ▲]

Detailed reference viewed: 90 (5 ULg)
See detailLa prééclampsie: de la physiopathologie et prise en charge
Brichant, Jean-François ULg

Conference (2007, March 22)

Detailed reference viewed: 8 (0 ULg)
See detailSynthèse et clôture du séminaire
Halleux, Jean-Marie ULg

Conference (2007, March 21)

Detailed reference viewed: 1 (0 ULg)
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See detailUS/India Civil Nuclear Cooperation Initiative: the Question of Safeguards
Michel, Quentin ULg

Conference (2007, March 20)

Detailed reference viewed: 5 (1 ULg)
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See detailMyosite focale sur atteinte radiculaire S1
Kaux, Jean-François ULg

Conference (2007, March 19)

Detailed reference viewed: 95 (20 ULg)
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See detailL’art minimaliste américain et la question du neutre
Hagelstein, Maud ULg

Conference (2007, March 19)

Detailed reference viewed: 8 (1 ULg)
See detailLe chewing-gum et la nutrition : clichés et nouveaux mots du pouvoir
Durand, Pascal ULg

Conference (2007, March 17)

Detailed reference viewed: 7 (2 ULg)
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See detailLe conflit dans l'état civil : l'envers du droit chez Thomas Hobbes
Herla, Anne ULg

Conference (2007, March 15)

Detailed reference viewed: 1 (0 ULg)
See detailImpacts of vegetation changes on LGM climate
Henrot, Alexandra ULg; François, Louis ULg; Munhoven, Guy ULg

Conference (2007, March 12)

The impacts of vegetation change on the climate at the Last Glacial Maximum are investigated with the Earth System Model of Intermediate Complexity Planet Simulator and the dynamic vegetation model Caraib ... [more ▼]

The impacts of vegetation change on the climate at the Last Glacial Maximum are investigated with the Earth System Model of Intermediate Complexity Planet Simulator and the dynamic vegetation model Caraib (CARbon Assimilation in the Biosphere). [less ▲]

Detailed reference viewed: 19 (5 ULg)
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See detailThe fringes of psychosis proneness: unfolding the domains of risk
Laroi, Frank ULg

Conference (2007, March 10)

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See detailLe regard des intervenants et l'éventail des parents
Absil, Gaëtan ULg; Denis, Marie-Elise

Conference (2007, March)

Detailed reference viewed: 60 (17 ULg)
See detailRigid body attitude synchronization: a consensus approach
Sarlette, Alain ULg; Sepulchre, Rodolphe ULg; Leonard, Naomi

Conference (2007, March)

Detailed reference viewed: 19 (4 ULg)
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See detailLa langue et le réel. Réflexions sur la motivation iconique
Polis, Stéphane ULg

Conference (2007, February 28)

Detailed reference viewed: 9 (0 ULg)
See detailWhen Mass Spectrometry meets Spectroscopy: A Different Perspective on Ion Photodissociation
Gabelica, Valérie ULg

Conference (2007, February 27)

Photodissociation methods are more and more widely used in analytical mass spectrometry as an alternative to collision-induced dissociation. A well known example is infrared multiphoton dissociation ... [more ▼]

Photodissociation methods are more and more widely used in analytical mass spectrometry as an alternative to collision-induced dissociation. A well known example is infrared multiphoton dissociation (IRMPD) with CO2 lasers (wavelength 10.6 µm), which is often preferred to SORI-CID in FTICR mass spectrometers. IR photons are absorbed by the vibrational modes of the ion, and this vibrational energy is redistributed all over the molecule. The fragmentation channels observed are usually the same as for CID. Recently, new possibilities offered by UV lasers of fixed wavelength (i.e. 157 nm or 193 nm) for peptide fragmentation were described. On the contrary to IRMPD, irradiation at these UV wavelengths gives rise to fragmentation channels which are unprecedented in CID, suggesting that photochemical reactions take place. The prerequisite for ion photodissociation is photon absorption. In the infrared, photon absorption results in the excitation of vibrational modes. Anharmonic coupling of the excited vibrational modes with other vibrational modes of the ion results in a rapid intramolecular vibrational energy redistribution (IVR). The energy of an IR photon is too low for the ion to dissociate (0.117 eV/photon for a 10.6 µm CO2 laser). Multiple cycles of absorption and IVR are necessary for IR photodissociation to occur (hence the term multiphoton). Because the first step in photodissociation is photon absorption, the recording of the photodissociation yield as a function of the photon wavenumber gives information on the vibrational modes of the ion. This is the basic principle of infrared spectroscopy experiments inside the mass spectrometer. This technique will be illustrated by a recent example on DNA single strands and quadruplex structures. The shifting of the vibrational frequencies corresponding to guanine C=O stretch gives information on the base pairing in the DNA ion in the gas phase. The situation is somewhat different with UV photons, which may lead to either electronic excitation of the ions or direct electron ejection. Electronic excited states may evolve in different ways: (1) Internal conversion to a vibrationally excited electronic ground state. Resulting fragments would then be similar to CID and IRMPD. This process can be multiphotonic and could be coined UVMPD. (2) Electron autodetachment, leading to the formation of radicals that can be further fragmented to obtain ECD-like or EDD-like fragments. (3) Photochemical reactions giving rise to unprecedented fragmentation channels. In all three cases, product ion yield is conditioned by photon absorption by an electronic state, meaning that UV spectroscopy of gas-phase ions can be performed with a mass spectrometer. We recently explored the effects of photon absorption on multiply charged DNA anions. Depending on the photon wavelength and on the chromophores, all three situations could be observed. Electron photodetachment is the major channel observed when using wavelengths corresponding to DNA base absorption.1,2 When irradiated at proper wavelength, chromophoric DNA ligands also give rise to electron photodetachment. UV-visible spectra of the DNA duplexes and complexes were recorded and compared with solution-phase spectra. Finally, a porphyrin ligand gives rise to specific fragmentation pathways when irradiated at 450 nm, while photodetachment is observed at 260 nm. The most recent results will be presented and discussed. 1. Gabelica, V.; Tabarin, T.; Antoine, R.; Rosu, F.; Compagnon, I.; Broyer, M.; De Pauw, E.; Dugourd, P. Electron Photodetachment Dissociation of DNA Polyanions in a Quadrupole Ion Trap Mass Spectrometer. Anal. Chem. 2006, 78 (18), 6564. 2. Gabelica, V.; Rosu, F.; Tabarin, T.; Kinet, C.; Antoine, R.; Broyer, M.; De Pauw, E.; Dugourd, P. Base-Dependent Electron Photodetachment from Negatively Charged DNA Strands upon 260-nm Laser Irradiation. J. Am. Chem. Soc. 2007, accepted for publication. [less ▲]

Detailed reference viewed: 34 (1 ULg)
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See detailSecondary dispersal by dung beetles of seeds primarily dispersed by tamarins
Culot, Laurence ULg

Conference (2007, February 22)

Detailed reference viewed: 9 (1 ULg)
See detailImpact des mesures judiciaires alternatives pour les consommateurs de drogues
Fincoeur, Bertrand ULg

Conference (2007, February 21)

Detailed reference viewed: 8 (0 ULg)
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See detailInternational Foundation for Research in Paraplegia
Martin, Didier ULg

Conference (2007, February 20)

Detailed reference viewed: 1 (0 ULg)
Peer Reviewed
See detailL'emprunt linguistique comme marqueur de vitalité des langues
Baiwir, Esther ULg

Conference (2007, February 09)

Detailed reference viewed: 26 (0 ULg)
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See detail"Ethno-évaluation" : le savoir des acteurs comme théorie de l'action
Absil, Gaëtan ULg

Conference (2007, February)

Detailed reference viewed: 56 (29 ULg)
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See detail3D image analysis characterization of dried banana
Léonard, Angélique ULg; Devahastin, Sakamon; Blacher, Silvia ULg

Conference (2007, February)

Detailed reference viewed: 25 (0 ULg)
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See detailTransfert d'image et hybridation post-traumatique
Hamers, Jérémy ULg

Conference (2007, February)

Detailed reference viewed: 7 (0 ULg)
See detailSuivi diachronique de l’analyse de corpus partagés
Bénel, Aurélien; Lejeune, Christophe ULg

Conference (2007, January 26)

Les anthropologues des sciences ont développé un mode d'inscription permettant le suivi de l'innovation qu'ils appellent "graphe socio-technique". Cette contribution présente les tentatives d'application ... [more ▼]

Les anthropologues des sciences ont développé un mode d'inscription permettant le suivi de l'innovation qu'ils appellent "graphe socio-technique". Cette contribution présente les tentatives d'application de ce dispositif de visualisation au suivi de l'activité sur des plateformes informatiques. Elle soulève des difficultés à la fois techniques et méthodologiques. [less ▲]

Detailed reference viewed: 14 (3 ULg)
See detailLa pression intracrânienne normale et pathologique
Martin, Didier ULg

Conference (2007, January 22)

Detailed reference viewed: 7 (2 ULg)
See detailLe néokantisme comme forme symbolique ? Merleau-Ponty et Panofsky
Cormann, Grégory ULg

Conference (2007, January 17)

Detailed reference viewed: 18 (0 ULg)
See detailLes insultes de la cour de récréation
Meunier, Deborah ULg

Conference (2007, January 12)

Detailed reference viewed: 17 (1 ULg)
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See detailMonitoring an odour in the environment with an electronic nose : requirements for the signal processing
Romain, Anne-Claude ULg; Delva, Julien ULg; Nicolas, Jacques ULg

Conference (2007, January)

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual measurement techniques of odour use human olfaction or conventional ... [more ▼]

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual measurement techniques of odour use human olfaction or conventional analytical techniques. The first category represents the real odour perception but is not applicable to measure continuously bad odours in the field. The second class of techniques gives the mixture composition but not the global information representative of the odour perception. The e-nose has the potentialities to combine "the odour perception" and the "monitoring in the field". However to be able to reach that goal, the signal processing has to be adapted to work in complex environment. The research group in Arlon has more than ten years experience in the measure of environmental malodours in the field. The paper presents the minimal requirements that the group considers as essential for artificial olfaction system to become successful for this application. [less ▲]

Detailed reference viewed: 47 (17 ULg)
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See detailAbstract numeration systems and recognizability
Charlier, Emilie ULg

Conference (2007, January)

In this talk, I will present some results concerning multiplication by a constant in an abstract numeration system built on a bounded language. More precisely, we will show that this operation does not ... [more ▼]

In this talk, I will present some results concerning multiplication by a constant in an abstract numeration system built on a bounded language. More precisely, we will show that this operation does not preserve regularity, and therefore cannot be computed by a finite automaton. [less ▲]

Detailed reference viewed: 5 (1 ULg)
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See detailParturition Induction in the mare. Why and when? Case Report
Ponthier, Jérôme ULg; Salciccia, Alexandra ULg; Sandersen, Charlotte ULg et al

Conference (2007, January)

INTRODUCTION Some conditions require induction of parturition: colic, severe hyperlipemia, prepubian tendon rupture, premature placental separation, hydroallantoïd, and foetal distress2,4,5. Prolonged ... [more ▼]

INTRODUCTION Some conditions require induction of parturition: colic, severe hyperlipemia, prepubian tendon rupture, premature placental separation, hydroallantoïd, and foetal distress2,4,5. Prolonged gestation is not a good indication1,4. Protocols using oxytocin, prostaglandins or corticosteroids can induce parturition2,3,4,5. Most induction protocols use low doses of oxytocin2,3,5. OBJECTIVE On the basis of a clinical case, this poster will discuss the indications, the methods and the risks of parturition induction in the mare. CLINICAL CASE A pony mare at day 310 of pregnancy is presented for colic with poor prognosis. The foetal parameters are good and the cervix begins to open. There is no milk in the udder. The decision to save the foal is taken and parturition is induced by one oxytocin bolus (20 I.U./IV) followed by an oxytocin infusion (100 I.U. in 1000ml saline). After assisted foaling, the foal rises and sucks commercial colostrum within 30 minutes. Soon, the foal becomes depressed and, despite treatment with commercial plasma, tube feeding and antibiotics, dies at day 2. DISCUSSION This case required immediate induction of foaling, which was achieved by administration of high doses of oxytocin. Commonly, high doses of oxytocin induce dystocia because the foal has no time to move to correct (dorso-sacral) presentation1,2,5. The risks for the foal include absence of colostrum and foetal immaturity1,2,3,4,5. Even after day 300, the prognosis is poor1,2,3,4. A good prognostic indicator of the foal’s maturity (lung, and other systems) is the electrolytes concentration in the mother’s milk2,4. These protocols should be used when foetal maturity is ascertained or as last resort1,2,3,4. CONCLUSIONS Foaling induction is risky for dystocia and foal outcome. It should be reserved to cases where foal’s maturity can be assessed. [less ▲]

Detailed reference viewed: 90 (14 ULg)
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See detailCutting planes from lattice-point-free polyhedra
Louveaux, Quentin ULg

Conference (2007, January)

In this talk, we generalize the concept of a split (that leads to split cuts) to any lattice-point-free polyhedron. We show how we can generate cutting planes for a polyhedron from these objects ... [more ▼]

In this talk, we generalize the concept of a split (that leads to split cuts) to any lattice-point-free polyhedron. We show how we can generate cutting planes for a polyhedron from these objects. Associated to any lattice-point-free polyhedron, we define a "split-dimension" (which is equal to 1 in the case of a split in the usual sense). We then consider the operation of adding to a polyhedron all cutting planes that we can obtain from considering all the lattice-point-free polyhedra with a split-dimension lower or equal to d. We call the obtained object the "d-dimensional split closure" of the initial polyhedron. We discuss whether this object is again a polyhedron or not. As an important illustration, we focus on objects of split-dimension equal to 1 or 2. [less ▲]

Detailed reference viewed: 11 (0 ULg)
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See detailRestrictive annuloplasty for ischemic mitral regurgitation may induce functional mitral stenosis.
Magne, Julien ULg; Sénéchal, M; Mathieu, P et al

Conference (2007)

Detailed reference viewed: 3 (0 ULg)
See detailPsychanalyse et psychothérapie psychanalytique
Naziri, Despina ULg

Conference (2007)

Detailed reference viewed: 20 (0 ULg)
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See detailPhysiopathologie des troubles psychosomatiques du nourrisson
Battisti, Oreste ULg

Conference (2007)

Une mère rencontre son enfant, les intervenants se rencontrent. Les aspects suivants sont abordés: la santé pré et post-natale; évaluation des défaillanes précoces; les besoins des services judiciaires ... [more ▼]

Une mère rencontre son enfant, les intervenants se rencontrent. Les aspects suivants sont abordés: la santé pré et post-natale; évaluation des défaillanes précoces; les besoins des services judiciaires; manifestations somatiques d'une triade en souffrance; attents et besoins de gynécologues et des pédiatres. [less ▲]

Detailed reference viewed: 79 (6 ULg)
See detailInterest of DOC in the study of consciousness
Vanhaudenhuyse, Audrey ULg

Conference (2007)

Detailed reference viewed: 4 (0 ULg)
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See detailL'Etat, les marchés des produits agricoles et le paysan
Lebailly, Philippe ULg

Conference (2007)

Detailed reference viewed: 54 (10 ULg)
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See detailRegulation by androgens of the expression of the EGF receptor family members in prostate cancer cells
Pignon, Jean-Christophe; Delacroix, Laurence; Nolens, Grégory et al

Conference (2007)

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See detailL’évolution du peuplement herpétologique en Région wallonne (Belgique)
Jacob, Jean-Paul; Percsy, Christiane; De Wavrin, Hellin et al

Conference (2007)

Detailed reference viewed: 24 (0 ULg)
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See detailExperimental validation protocol for micro-CT as screening tool for bone tissue engineering scaffolds
Kerckhofs, Greet ULg; Schrooten, Jan; Van Cleynenbreugel, Tim et al

Conference (2007)

Detailed reference viewed: 6 (1 ULg)
See detailAssimilation of High-Frequency Radar Currents in a Nested Model of the West Florida Shelf
Barth, Alexander ULg; Alvera Azcarate, Aïda ULg; Weisberg, R. H.

Conference (2007)

High-frequency radar currents are assimilated in a West Florida Shelf (WFS) model based on the Regional Ocean Model System (ROMS), which is nested in the Atlantic Hybrid Coordinate Ocean Model (HYCOM) for ... [more ▼]

High-frequency radar currents are assimilated in a West Florida Shelf (WFS) model based on the Regional Ocean Model System (ROMS), which is nested in the Atlantic Hybrid Coordinate Ocean Model (HYCOM) for the purpose of including both local and deep-ocean forcing, particularly the Gulf of Mexico Loop Current. Tides are not included in this model. An ensemble simulation of the WFS model is carried out under different wind-forcings in order to estimate the error covariance of the model state vector and the covariance between ocean currents and winds. Radial currents measured by high-frequency radar antennas near Saint Petersburg and Venice, Florida, USA, are assimilated using this ensemble-based error covariance. Different assimilation techniques using a time-average ensemble, a filter to reduce surface-gravity waves and an extended state vector including wind stress were tested. Results of the WFS model assimilating surface currents show an improvement of the model currents not only at the surface but also at depth. [less ▲]

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See detailCathéter épicutanéo-cave double voie versus simple voie: une étude randomisée chez le nouveau-né prémature
Marion, W.; Battisti, Oreste ULg; Anthopoulou, N. et al

Conference (2007)

Detailed reference viewed: 82 (6 ULg)
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See detailLong term behaviour of the Boom Clay: influence of viscosity on the pore pressure distribution
Coll, Cécile; Charlier, Robert ULg; Li, Xiang Ling et al

Conference (2007)

Detailed reference viewed: 38 (6 ULg)
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See detailComparison of ENFA and GLM modelling for summer habitat suitability of the sperm whale in the northwestern Mediterranean Sea
Praca, Emilie; Gannier, Alexandre; Das, Krishna ULg et al

Conference (2007)

Detailed reference viewed: 18 (2 ULg)
See detailDetecting awareness in impaired states of consciousness
Vanhaudenhuyse, Audrey ULg

Conference (2007)

Detailed reference viewed: 2 (1 ULg)
See detailTowards a carbon balance at the Lonzée crop site
Moureaux, Christine ULg; Debacq, Alain ULg; Suleau, Marie ULg et al

Conference (2007)

Detailed reference viewed: 12 (4 ULg)
See detailA West Florida Shelf ROMS Nested into HYCOM: Ensemble-based Assimilation of HF-Radar Surface Currents and a 2005 Red Tide Case Study with Simulated Drifters
Barth, Alexander ULg; Alvera Azcarate, Aïda ULg; Weisberg, R. H.

Conference (2007)

A West Florida Shelf (WFS) model is constructed by nesting the Regional Ocean Model System (ROMS) in the Atlantic Hybrid Coordinate Ocean Model (HYCOM) to include both local and deep-ocean forcing ... [more ▼]

A West Florida Shelf (WFS) model is constructed by nesting the Regional Ocean Model System (ROMS) in the Atlantic Hybrid Coordinate Ocean Model (HYCOM) to include both local and deep-ocean forcing, particularly the Gulf of Mexico Loop Current (LC). Hindcast experiments from 2004 to 2006 are presented and compared to observed temperature (moorings and BSOP profiling floats), ADCP velocity time series and HF-Radar surface currents. Two different mixing schemes (Mellor Yamada level 2.5 and K-Profile Parameterization, KPP) are tested and the importance of the vertical resolution for mixing is addressed. The model results of those different configurations are compared to temperature observations on the shelf. Results obtained with the Mellor Yamada scheme are closer to observations during winter (negative buoyancy flux and strong winds) while in summer (positive buoyancy flux and in general weaker wind) the KPP scheme produces more realistic results. Given the present HYCOM configuration we assessed the benefit of nesting ROMS in HYCOM compared to nesting ROMS in climatology. The model solutions on the shelf were compared to various in situ data. The model performed best when using the HYCOM boundary values. Simulated trajectories for drifters deployed off Tampa Bay and Sarasota were used to address the evolution of Karenia brevis concentrations during the 2005 red tide. Near surface drifters were advected offshore, whereas drifters deployed in the bottom Ekman layer matched the subsequently observed Karenia brevis distributions, showing the importance of the 3D structure of coastal ocean currents for red tide on the WFS. As a first attempt at assimilating CODAR surface currents we used an ensemble simulation carried out under different wind forcings to estimate the error covariance of the model state vector and the covariance between the ocean currents and the wind. Improvements were obtained for the modeled currents, not only at the surface, but also at depth. [less ▲]

Detailed reference viewed: 31 (4 ULg)
See detailY a-t-il un discours universitaire dans la salle (de cours)?
Defays, Jean-Marc ULg

Conference (2007)

Detailed reference viewed: 18 (2 ULg)
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See detailComparative pharmacokinetics of two intravenous dosage rates of tiludronate in healthy adult horses
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, Jérôme et al

Conference (2007)

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg ... [more ▼]

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg (group 2, n=6) in healthy adult horses. Plasma samples were collected at regular intervals for a period of 16 and 7 days in groups 1 and 2 respectively. Continuous urine collection for determination of cumulative urinary excretion of tiludronate was performed during 16 and 7 days in groups 1 and 2 respectively, and over 24-hour periods every 10 days until 60 days after the last tiludronate administration in both groups. Tiludronate concentrations were obtained in all plasma and urine samples using HPLC with UV detection. Plasma pharmacokinetic parameters were determined using a noncompartmental approach. Group 1 mean (± SD) AUCss was 3.76 (±0.698) mg.h.L-1 and group 2 mean (± SD) AUCtot was 39.07 (±3.699) mg.h.L-1. Mean (± SD) clearance (Cl) was 0.027 (±0.0042) and 0.026 (±0.0022) L.h-1.kg-1 in groups 1 and 2, respectively. Neither the dose corrected AUC (p=0.724) nor the Cl (p=0.528) were statistically different between groups. Relative plasma bioavailability (infusion versus bolus) was 103%. Cumulative urine tiludronic acid excretion could not be compared between groups due to analytical limitations (LOQ of 0.025 mg.L-1), which led to numerous missing data particularly in group 1, and an inability to conduct appropriate statistical and pharmacokinetic analyses. In conclusion, both dosage rates of tiludronate were considered bioequivalent with regards to plasma pharmacokinetics. [less ▲]

Detailed reference viewed: 25 (1 ULg)