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See detailThe daughters of family business: Developing a global research agenda
Nelson, Teresa; Constantinidis, Christina ULg

Conference (2009, June 18)

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See detailNew fluorinated surfactants for nanogels preparation
Alaimo, David ULg; Rieger, Jutta; Beigbeder, Alexandre et al

Conference (2009, June 18)

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer ... [more ▼]

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer and used as stabilizers for the dispersion polymerization of 2-hydroxyethyl methacrylate (HEMA) in fluorinated solvent, namely alpha,alpha,alpha-trifluorotoluene (TFT). The effect of the amount and the architecture of the copolymer on the size and the stabilization of the particles was studied. Whatever the experimental conditions, scanning electron microscopy showed the formation of submicronic (typically about 300 nm) spherical particles, with a narrow size distribution. The principal difference emerges from the concentration of surfactant. Indeed, at higher copolymer concentration, smaller and less aggregated particles were produced. These results were confirmed by dynamic light scattering but these measurements also revealed the presence of larger aggregates (1,5 micrometer). Furthermore, the surfactant properties of the copolymers were investigated by measuring the interfacial tension at the H2O/TFT interface, and the results were correlated to their stabilizing efficiency in the dispersion polymerization of HEMA. [less ▲]

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See detailImpact of contamination on empirical and theoretical error
Ruwet, Christel ULg; Haesbroeck, Gentiane ULg

Conference (2009, June 18)

Classification analysis allows to group similar objects into a given number of groups by means of a classification rule. Many classification procedures are available : linear discrimination, logistic ... [more ▼]

Classification analysis allows to group similar objects into a given number of groups by means of a classification rule. Many classification procedures are available : linear discrimination, logistic discrimination, etc. Focus in this poster will be on classification resulting from a clustering analysis. Indeed, among the outputs of classical clustering techniques, a classification rule is provided in order to classify the objects into one of the clusters. More precisely, let F denote the underlying distribution and assume that the generalized kmeans algorithm with penalty function is used to construct the k clusters C1(F), . . . ,Ck(F) with centers T1(F), . . . , Tk(F). When one feels that k true groups are existing among the data, classification might be the main objective of the statistical analysis. Performance of a particular classification technique can be measured by means of an error rate. Depending on the availability of data, two types of error rates may be computed: a theoretical one and a more empirical one. In the first case, the rule is estimated on a training sample with distribution F while the evaluation of the classification performance may be done through a test sample distributed according to a model distribution of interest, Fm say. In the second case, the same data are used to set up the rule and to evaluate the performance. Under contamination, one has to replace the distribution F of the training sample by a contaminated one, F(eps) say (where eps corresponds to the fraction of contamination). In that case, thetheoretical error rate will be corrupted since it relies on a contaminated rule but it may still consider a test sample distributed according to the model distribution. The empirical error rate will be affected twice: via the rule and also via the sample used for the evaluation of the classification performance. To measure the robustness of classification based on clustering, influence functions of the error rate may be computed. The idea has already been exploited by Croux et al (2008) and Croux et al (2008) in the context of linear and logistic discrimination. In the computation of influence functions, the contaminated distribution takes the form F(eps) = (1 − eps)*Fm + eps* Dx, where Dx is the Dirac distribution putting all its mass at x. It is interesting to note that the impact of the point mass x may be positive, i.e. may decrease the error rate, when the data at hand is used to evaluate the error. [less ▲]

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See detailLa réception de l'approche law & economics par les juristes
Sibony, Anne-Lise ULg

Conference (2009, June 16)

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See detailMyopia, redistribution and pensions
Pestieau, Pierre ULg

Conference (2009, June 15)

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See detailStudy of diffusive limitations in Proton Exchange Membrane Fuel Cells (PEMFC)
Brigaudet, M.; Berthon-Fabry, S.; Beauger, C. et al

Conference (2009, June 14)

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See detailCarbon xerogels as supports for catalysts and electrocatalysts
Job, Nathalie ULg; Berthon-Fabry, S.; Lambert, Stéphanie ULg et al

Conference (2009, June 14)

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See detailClean Development Mechanisms (CDM) and Sustainable Development in South Countries
Ozer, Pierre ULg

Conference (2009, June 13)

The Clean Development Mechanism (CDM) allows emission-reduction (or emission removal) projects in developing countries to earn Certified Emission Reduction (CER) credits, each equivalent to one tonne of ... [more ▼]

The Clean Development Mechanism (CDM) allows emission-reduction (or emission removal) projects in developing countries to earn Certified Emission Reduction (CER) credits, each equivalent to one tonne of CO2. These CERs can be traded and sold, and used by industrialized countries to a meet a part of their emission reduction targets under the Kyoto Protocol. The mechanism stimulates sustainable development and emission reductions, while giving industrialized countries some flexibility in how they meet their emission reduction limitation targets. Accepted projects must qualify through a rigorous and public registration and issuance process designed to ensure real, measurable and verifiable emission reductions that are additional to what would have occurred without the project. Between November 2004 and May 2009, the mechanism has registered 1653 projects and is anticipated to currently produce CERs amounting to 303 106 tonnes of CO2 equivalent yearly. The mechanism is extremely interesting since it is the first global, environmental investment and credit scheme of its kind, providing a standardized emissions offset instrument. However the geographical distribution of the CDM projects is revealing very large differences in between developing countries since China, India, Brazil and South-Korea totalise 82% of the CERs while Africa only represents 3,3% of the total. [less ▲]

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See detailValidité et objectivité entre logique et phénoménologie
Boccaccini, Federico ULg

Conference (2009, June 13)

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See detailDevelopment of multilayered chitosan-based nanofibers for tissue engineering
Croisier, Florence ULg; Aqil, Abdelhafid ULg; Detrembleur, Christophe ULg et al

Conference (2009, June 13)

By combining electrospinning and layer-by-layer deposition techniques, new porous material scaffolds of multilayered, chitosan-based nanofibers were produced. Layer-by-layer (LBL) is a well-known method ... [more ▼]

By combining electrospinning and layer-by-layer deposition techniques, new porous material scaffolds of multilayered, chitosan-based nanofibers were produced. Layer-by-layer (LBL) is a well-known method for surface coating, based on electrostatic interactions. It enables the controllable deposition of a variety of polyelectrolytes including synthetic and natural materials, with designable layer structure, defined layer thickness and size. Electrospinning (ESP) allows the fabrication of polymer fibers ranging from nanometers to a few microns in diameter, depending on the polymer characteristics (a.o. molecular weight, solution viscosity and conductivity) and processing conditions (electric potential, distance between syringe-capillary and collection plate, concentration, flow rate). Mats of nanofibers produced by ESP display a very large surface area-to-volume ratio and high porosity with very small pore size. The nanometric scale of electrospun fibers also proves a positive effect on cellular growth, as fiber mats mimic extracellular matrix structure. The association of these two techniques with the use of biocompatible and biodegradable polymers such as chitosan, gives outstanding prospects in the field of biomedical applications, especially for the preparation of wound dressings, artificial skin or tissue engineering scaffolds. In the present study, a charged copolymer, poly(methylmethacrylate-block-methacrylic acid), was added to a poly(ε-caprolactone) or poly(D,L-lactide) solution before electrospinning in order to prepare surface charged nanofibers. Oppositely charged polyelectrolytes – chitosan and poly(styrene sulfonate) or hyaluronic acid – were then alternately deposited on these aliphatic polyester fiber “cores” using LBL method. The aliphatic polyester core was also removed selectively to confirm the growth of a multilayered shell, obtaining hollow fibers. [less ▲]

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See detailTowards an optimal enforcement of Competition rules in Europe
Petit, Nicolas ULg

Conference (2009, June 12)

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See detailIR spectroscopy of DNA structures
Gabelica, Valérie ULg

Conference (2009, June 11)

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See detailMaternal transfer of mercury to offspring in phocids
Habran, Sarah ULg; Pomeroy, Paddy; Debier, Cathy et al

Conference (2009, June 09)

Marine mammals may display high mercury (Hg) levels in their tissues, which raises the question of the importance of toxic metal transfer from mother to offspring. Indeed, Hg could be transferred from ... [more ▼]

Marine mammals may display high mercury (Hg) levels in their tissues, which raises the question of the importance of toxic metal transfer from mother to offspring. Indeed, Hg could be transferred from mothers to fetuses via the placenta and to suckling pups via the milk, potentially affecting them during their most sensitive periods of development. Some lactating female phocids fast during the suckling period. This fasting period involves not only an important mobilization of energy reserves, but also mobilization of potentially associated contaminants. We studied and compared maternal transfer of Hg to offspring in two phocid species: the northern elephant seal (Mirounga angustirostris) from the Californian coast and the grey seal (Halichoerus grypus) from the Isle of May in Scotland. Total mercury concentrations (THg) were measured in whole blood and maternal milk of 20 mother-pup pairs of each species in early and late lactation. Methylmercury (MeHg) levels were also measured in the blood and milk of grey seals. Results indicated that Hg passed from the maternal tissue into the phocid milk. Milk showed a range of THg levels from 15 to 60 ppb (ng.g-1-wet-weight). From the first days after birth, pups displayed relatively high blood Hg levels suggesting that a Hg transfer through placenta occurred. Blood Hg levels in mothers and pups also varied significantly throughout lactation. While maternal levels doubled, pup levels were reduced by half between the beginning and the end of lactation. Remobilization of proteins and lipids during fasting and milk production in mothers might lead to a release of Hg in blood and therefore increase the levels in late lactation. On the contrary, Hg would be progressively stored in pup organs during their development. Decreasing Hg levels in pups also suggest that the Hg intake via the milk might be lower than that via the placenta. This study highlights a transplacental and transmammary transfer of Hg in both phocid populations. However, further toxicology studies are needed to help understand the potential impact of this Hg transfer. Results also showed that physiological processes such as lactation and/or fasting can modify Hg levels in the blood of mothers and pups. Therefore, such processes and body condition should be considered carefully when interpreting Hg levels in the framework of biomonitoring. [less ▲]

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See detailStudy of vocal therapy efficiency: Comparison of 2 methods
Morsomme, Dominique ULg; Vliegen, Liz; MARTINOT, Gisèle ULg

Conference (2009, June 06)

Our objective is to compare the efficiency of 2 methods of vocal therapy. Method A consists of exercises centred on the breath, the vibration and the resonance. Method B associates the principles of the ... [more ▼]

Our objective is to compare the efficiency of 2 methods of vocal therapy. Method A consists of exercises centred on the breath, the vibration and the resonance. Method B associates the principles of the muscular chains (Struyf) and the motor coordination ( Piret-Béziers) with the eutonia of G. Alexander. 11 patients (mean age: 32.9) presenting a functional dysphonia or nodules of the vocal folds were distributed in both groups. We compared their results pre and post therapy (interval: 6 months) at subjective (GRB, VHI) and objective (acoustics and aerodynamics) measures. We observe an improvement of the post therapeutic measures in both groups (VHI p < 0.005; maximum intensity p < 0.05; intensity range p < 0.05; frequency range p<0.05 and maximum frequency p< 0.05). We observe an improvement of the post therapeutic measures for the group A for the grade and the roughness on a sustained [a] ( p < 0.05) and for the grade, the roughness and the breathiness on text reading (p < 0.05). Both methods are equivalent to improve the vocal quality of the dysphonic patients in this study. [less ▲]

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See detailIntroduction et conclusions
Delfosse, Annick ULg

Conference (2009, June 05)

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See detailMéditations sartriennes de Bourdieu
Cormann, Grégory ULg

Conference (2009, June 04)

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See detailA simple method for determination of electrospray response factors of noncovalent complexes: application to DNA G-quadruplex binding and self-assembly
Gabelica, Valérie ULg; Amato, Jussara; Oliviero, Giorgia et al

Conference (2009, June 04)

Introduction Electrospray mass spectrometry (ESI-MS) is now widely used to investigate non-covalent assemblies, and the power of the method resides in the individual detection of the various ... [more ▼]

Introduction Electrospray mass spectrometry (ESI-MS) is now widely used to investigate non-covalent assemblies, and the power of the method resides in the individual detection of the various stoichiometries present in the mixture. However, to characterize the mixture quantitatively (i.e. to determine the concentration of each constituent), the biggest challenge comes from the fact that electrospray response factors of all constituents can be different, especially for constituents of significantly different masses and charges. Here we present a novel and simple method to determine the response factors of all constituents, using an internal standard. The method can be transposed to a wide variety of biological problems and to different ionization methods. Experimental All oligodeoxynucleotides were purchased from Eurogentec (Seraing, Belgium). G-quadruplexes formation is induced by addition of ammonium acetate (150 mM) to the guanine-rich strand. Polythymines (e.g. dT6) with m/z not overlapping with those of the complexes were used as internal standards. The ESI mass spectra were acquired using a Q-TOF Ultima Global (Waters, Manchester, UK) in the negative ion mode, with source parameters optimized for detecting the intact complexes. Quadruplex-ligand binding constants were quantified by titration of the quadruplex with the ligand (BOQ1, Dr. Teulade-Fichou). The kinetics of G-quadruplex self-assembly was monitored on-line, with the starting time defined by the addition of ammonium to the single strand. Peak areas were calculated using MassLynx and data were processed using Mathcad. Preliminary results Let us illustrate the method for the characterization of the self-assembly of dCGGTGGT. In NH4OAc, this G-rich strand forms a tetramer within a few hours, but the most stable species is an octamer, which is formed after a few days. The relative intensities of monomer, tetramer and octamer vary with the experimental settings: harsher conditions favor the transmission of the larger complexes. It is therefore foolish to assume that the response factors of the monomer, tetramer and octamer are equal. Using dT6 as an internal reference, we monitored the self-assembly kinetics by recording at several time points the following intensities: I(ref2-), I(G12-), I(G45-) and I(G89-), where Gn indicates a complex containing n G-rich strands. For each species Gn, we define Rn as its response factor relative to that of the reference: [Gn]/[ref] = Rn * I(Gn)/I(ref). At each time point the mass balance equation for the strand concentration must be satisfied: [G]tot = [G1] + 4[G4] + 8[G8]. Substituting with the definition of Rn’s one obtains a set of equations: [G]tot = [ref] * {R1*(I(G1)/I(ref) + 4R4*I(G4)/I(ref) + 8R8*I(G8)/I(ref)}. If the number of equations (time points) is greater than the number of unknown response factors, the least-squares fit to this system of equations is calculated using the Moore-Penrose pseudoinverse of the matrix constituted by the intensity ratios. Once all response factors are known, concentrations are recalculated at each time point, providing detailed characterization of the reaction kinetics, including reaction intermediates. We will also show that the same method can be used to quantify ligand binding using titration of the substrate by the ligand. This will be illustrated with titration of the quadruplex (TGGGGT)4 by ligand BOQ1. This ligand binds to the quadruplex and also produces ligand-bridged quadruplex multimers, which the present method allows quantifying for the first time. [less ▲]

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See detailA test of the Job Demands-Resources model: A social identity theory perspective.
Barbier, Marie ULg; Hansez, Isabelle ULg

Conference (2009, June 03)

The Job Demands-Resources mode has given rise to numerous studies aimed at a better understanding of positive and negative aspects of wellbeing at work. The existence of a motivational and an energetic ... [more ▼]

The Job Demands-Resources mode has given rise to numerous studies aimed at a better understanding of positive and negative aspects of wellbeing at work. The existence of a motivational and an energetic process leading to, respectively, engagement and exhaustion has been demonstrated. The aim of our study is to test this model using predictors derived from Social Identity Theory (or SIT). We hypothesize that working in a negatively valued occupation is associated with exhaustion and health problems, whereas a high identification with one’s occupational group is associated to engagement and low intent to quit the organisation (or IQ). Structural equation modelling was performed on data collected in a public administration (N = 954). We collected measures of occupation value, group identification, exhaustion, engagement, health problems and IQ. Items were parcelled based on their skewness. Excepted from Chi² being significant (p = .00), fit indices were satisfactory. The link between engagement and IQ is not significant but all other links go in the expected direction. We conclude that a test of the JDR model using SIT brings conclusive results. As a further step, it might be interesting to test interactive effects: results suggest that identification might buffer the relation between occupation value and exhaustion. Second, it might be interesting to introduce boundaries permeability, another key concept of SIT, as a third predictor. [less ▲]

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See detailMemory for visual items of central or marginal interest in complex scene: Impact of eye movements and subject’s expertise.
Blavier, Adelaïde ULg; Nyssen, Anne-Sophie ULg

Conference (2009, June 03)

In complex scene, memory for central interest items is better than memory for marginal interest items and this difference remains stable independently of the scene presentation duration (Melcher, 2006 ... [more ▼]

In complex scene, memory for central interest items is better than memory for marginal interest items and this difference remains stable independently of the scene presentation duration (Melcher, 2006). However, without eye movement recording, it is not possible to know whether central interest items are better remembered because they are more fixated or because they are more meaningful. To answer this question, we analysed the memory of complex scenes (paintings) according to the eye movements and subjects’ expertise. 15 novice subjects and 15 art historians (experts) were asked to look at 6 paintings that were separately and randomly presented for 10 seconds. After each painting presentation, subjects were asked questions about pictorial details of 3 categories: details of central or marginal interest and background information. Although experts had prior knowledge about the paintings, the accuracy of answers about the pictorial details did not differ between both groups: all subjects showed best memory for central information while they failed to remember background information and marginal details. Despite a longest time spent in the background zone, memory for these details was poorer than for central interest items, suggesting the importance of the meaning over the fixation duration. Eye movement recordings also showed novice’s answers were more accurate when they looked longer at the asked detail and when this detail was watched early on in the presentation while in the expert group, the accuracy of the answer was not influenced by the duration and moment they watched the asked detail. [less ▲]

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See detailImages et pathos. Figures de la créativité chez Aby Warburg
Hagelstein, Maud ULg

Conference (2009, June 03)

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See detailNew developments in the functionalization of aliphatic polyesters by "click" copper-catalyzed azide-alkyne cycloaddition
Lecomte, Philippe ULg; Riva, Raphaël ULg; Schmeits, Stephanie ULg et al

Conference (2009, June 03)

Nowadays, biodegradable and biocompatible aliphatic polyesters are widely used as environmentally friendly thermoplastics and biomaterials. Nevertheless, the absence of any pendant functional group is a ... [more ▼]

Nowadays, biodegradable and biocompatible aliphatic polyesters are widely used as environmentally friendly thermoplastics and biomaterials. Nevertheless, the absence of any pendant functional group is a severe limitation for the development of novel applications. Our strategy aiming at functionalizing aliphatic polyesters relies on the “click” copper-catalyzed cycloaddition (CuAAC) of alkynes duly substituted by functional groups or even chains onto PCL bearing pendant azides. The aliphatic polyesters bearing pendant azides have been very efficiently synthesized by a straightforward approach, which relies on the ring-opening copolymerization of αClεCL (or γBrεCL) and εCL (or lactide) followed by reaction with sodium azide to convert pendant chlorides or bromides into azides. The alternative reported by Emrick et al. is based on the CuAAC reaction of azides substituted by any functional group onto copolyesters of poly(ε-caprolactone) bearing pendant alkynes. Interestingly enough, Emrick et al. carried out the CuAAc reaction in water at 80°C. Unfortunately, it turned out, at least in our hands, that these conditions can not be extended to the derivatization of more sensitive aliphatic polyesters because degradation was then unavoidable. Nevertheless, we found out that degradation can be minimized whenever the CuAAC reaction is carried out in an organic solvent at lower temperature. Typically, the CuAAC reaction was carried out in DMF or THF at 35°C. Recently, it was shown that supercritical carbon dioxide can be used as a more environmentally friendly solvent than DMF or THF. The contamination by catalytic residues of aliphatic polyesters functionalized by the CuAAC reaction is a severe limitation in view of future applications, especially in the biomedical field. In the last part of this talk, a special attention will be paid on our current efforts to get rid of copper residues. [less ▲]

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See detailStructure cordale, phonotraumatisme et lésions cordales
FINCK, Camille ULg

Conference (2009, June)

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See detailMALDI-Top-Down of Proteins: Overview and Applications
Quinton, Loïc ULg; Demeure, Kevin ULg; Resemann, Anja et al

Conference (2009, June)

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See detailThe timed 100-meter walk test: an easy-t-use, sensitive tool to detect and evaluate restricted walking capacities in multiple sclerosis.
Belachew, Shibeshih ULg; CALAY, Philippe ULg; DELVAUX, Valérie ULg et al

Conference (2009, June)

Objectives: The primary aim of this study was to develop a quantitative ambulation test that correlates with the maximal walking distance in multiple sclerosis (MS) patients. Background: The timed 25-foot ... [more ▼]

Objectives: The primary aim of this study was to develop a quantitative ambulation test that correlates with the maximal walking distance in multiple sclerosis (MS) patients. Background: The timed 25-foot walk (T25FW) weakly correlates with overall walking capacities of MS patients. We developed the timed 100-meter walk test (T100T), which besides reflecting speed may be more sensitive to other walking parameters such as gait and spasticity-related fatigue. Methods: In the T100T, the patient is instructed to walk as fast as possible on a distance of 100 meters. Eighty-eight MS patients with an EDSS score from 0 to 5.5 and 60 normal controls performed the T100T and the T25FW. In addition, 30 normal controls and 30 patients performed the tests twice. Results: T25FW (R2= 0.79) and T100T (R2 = 0.89) correlated with the nonlinear distribution of EDSS scores. The correlation between T100T and T25FW values was high (r2 = 0.81) for the low (0 to 3.0) and high (3.5-5.5) scores of EDSS. The intra-class correlations were excellent and similar for both tests. The range of T100T values in MS patients (40.4 to 114.7 seconds) was 10-fold wider than that of the T25FW (3.0 to 9.1 seconds). The univariate distribution analyses demonstrated that abnormal T100T values appear to be more sensitive than T25FW to predict walking limitations. Finally, the correlation with the reported and/or actual maximal walking distance without aid and rest was significantly better for T100T. Conclusions : The T100T proves to be superior to the T25FW in terms of discriminatory power for the detection and evaluation of restricted walking capacities in MS. The T100T should be of interest for clinical trials studying disability worsening and improvement across the spectrum of EDSS. It may provide more sensitive measure for ambulation change in quantifying progressive MS pathology. [less ▲]

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See detailThe genome of a gut strain of Bacillus subtilis
Schyns, G.; Pereira-Leal, J.; Serra, C. et al

Conference (2009, June)

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See detailObjets Rebondissants Non Investigues
Dorbolo, Stéphane ULg; Terwagne, Denis ULg

Conference (2009, June)

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See detailProfessionalisation and Innovation: Friends or Ennemies?
Poumay, Marianne ULg

Conference (2009, June)

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See detailValidity of bench models in the learning of minimal invasive surgery
Blavier, Adelaïde ULg

Conference (2009, June)

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See detailNatalizumab induced freedom from disease activity after failure to previous therapy in relapsing remitting multiple sclerosis.
Belachew, Shibeshih ULg; Bartholome E.; DELVAUX, Valérie ULg et al

Conference (2009, June)

Objectives: To analyze the efficacy of natalizumab after switching relapsing-remitting multiple sclerosis (RRMS) patients from other disease modifying treaments (DMTs). Background: Natalizumab (Tysabri ... [more ▼]

Objectives: To analyze the efficacy of natalizumab after switching relapsing-remitting multiple sclerosis (RRMS) patients from other disease modifying treaments (DMTs). Background: Natalizumab (Tysabri) is a monoclonal antibody directed against VLA4 that was recently approved for the treatment of RRMS. Due to safety concerns, the use should be restricted to highly active patients and/or patients with insufficient response to other DMTs. The pivotal trials were not designed to examine the effect of natalizumab as an escalation monotherapy. Methods: Prospective, open label, observational study. All patients initiating natalizumab had experienced at least 1 relapse in the previous year under DMTs and had at least 1 Gd-enhancing lesion on their brain MRI. Previous treatment with interferon-beta (IFN-beta) or glatiramer acetate (GA) were stopped at least one week and azathioprine or mitoxantrone at least 3 months before switching. The minimum therapy duration with natalizumab was 6 months for all patients. 21 RRMS patients were included in this analysis. The mean age of the patients was 25,5 yo with mean disease duration of 6,8 years. All patients were under IFN-beta (17) or GA (4) during at least the previous year before starting natalizumab therapy. Four patients had also received azathioprine and 1 patient mitoxantrone. Results: The mean relapse rate in the previous year was 2.15 (1-4), the mean EDSS at baseline was 3.3 (1,0-6.0), the mean number of Gd+ lesions at baseline 2,58 (1-6). Under tysabri treatment the annualized relapse rate dropped to 0,20. Eleven patients improved their EDSS (0,5 to 1,5 steps down), others remained stable at 6 months. The mean number of Gd+ T1 lesions dropped to 0,23 and the mean number of new T2 lesions was 0.25 on the control MRI at 6 months. 55% of patients were free from disease activity, i.e. had no relapses, no EDSS progression, no new T2 lesion and no Gd+ T1 lesions after 6 months of Tysabri. 5 patients experienced minor adverse events (1 zona, 2 flu-like symptoms, 1 gastroenteritis, 1 allergic reaction). Conclusion: Natalizumab was well tolerated and safe as escalation therapy when previous DMTs had failed to control disease progression in this group of highly active RRMS patients. These results suggest comparable efficacy to the phase III AFFIRM trial of natalizumab when the drug is used in a context of breakthrough disease. Although data from preliminary analyses are promising, long term investigations are warranted. [less ▲]

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See detailActualités en impôts directs
Richelle, Isabelle ULg

Conference (2009, June)

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See detailprésentation des travaux de recherche en lutte biologique
Jijakli, Haissam ULg

Conference (2009, June)

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See detailcontroversies of inter-organizational ambidexterity
Degré, Julie ULg; Antoine, Mélanie ULg

Conference (2009, June)

Generally conceptualized at an intra-organizational level, ambidexterity can also appear at an inter-organizational level when organizations decide to collaborate and distribute activities of exploration ... [more ▼]

Generally conceptualized at an intra-organizational level, ambidexterity can also appear at an inter-organizational level when organizations decide to collaborate and distribute activities of exploration and activities of exploitation according to their specialty. In this paper, we investigate these collaborations, often presented as win-win solutions. On the basis of two case studies of R&D partnerships benefiting from regional subsidies, we show the tensions which cross these alliances and the controversies which divide the partners. Our analysis, based on actor-network theory, indicates that the conditions of a successful inter-organizational ambidexterity do not exist a priori. The success of the partnership rather rests on a continuous translation process creating the convergence between the stakeholders. [less ▲]

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See detailTheoretical Study of Transformation Mechanism for the Corundum-to-Rh2O3(II) Transition in Al2O3
Xu, Bin ULg; Dong, Jianjun; Stokes, Harold et al

Conference (2009, June)

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See detailOriginal cromakalim analogues as KATP channel openers
Florence, X.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

Conference (2009, June)

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See detailFrench Affirmative Action Based upon Spatial Inequalities: the case of inner city “Neighborhood Law and Justice Centres”
Lejeune, Aude ULg

Conference (2009, May 29)

In 1998, the French Parliament enacted a law regarding the struggle against discrimination . In response to this legislation, the French Minister of Justice implemented a new judicial structure (the ... [more ▼]

In 1998, the French Parliament enacted a law regarding the struggle against discrimination . In response to this legislation, the French Minister of Justice implemented a new judicial structure (the "Houses of Law") in areas which had been defined as "districts in difficulty" or "areas where the law is not applied anymore." The purpose of this structure was to provide advice to inner city inhabitants within these Houses of Law with the aim to reduce inequalities between the citizens who can hire private lawyers and the ones who cannot. First, this research examines the means by which the French Government implemented these affirmative action policies, which are an obstacle in the state's pursuit of the principle of equality; a fundamental precept of the French Republic . Instead of focusing on people, governmental policy targeted geographic areas, specifically inner city. Secondly, this research studies the work of private lawyers operating within the public sector judicial structures and asks whether these "Houses of Law" are equitable arrangements for all citizens due to their locational situation. [less ▲]

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See detailNouveaux outils de diagnostic in-vitro des allergies
Gadisseur, Romy ULg; Chapelle, Jean-Paul ULg; Cavalier, Etienne ULg

Conference (2009, May 29)

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See detailMMPs regulation of vascular permeability in cancer
Sounni, Nor Eddine ULg

Conference (2009, May 29)

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Peer Reviewed
See detailEspace originaire kantien et espace transitionnel chez Winnicott
Seba, Jean-Renaud ULg

Conference (2009, May 29)

La distinction kantienne du sens interne et du sens externe présuppose un espace originaire préalable à la distinction elle-même. Cet espace originaire est éclairé par la notion winnicottienne d'espace ... [more ▼]

La distinction kantienne du sens interne et du sens externe présuppose un espace originaire préalable à la distinction elle-même. Cet espace originaire est éclairé par la notion winnicottienne d'espace transitionnel. [less ▲]

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See detailUne approche reposante (RESTful) des aspects opérationnels de la rétroconversion du Französisches Etymologisches Wörterbuch (FEW)
Briquet, Cyril; Renders, Pascale ULg

Conference (2009, May 28)

Les articles du Französisches Etymologisches Wörterbuch (FEW) seront bientôt enrichis d'un balisage (XML) sémantique par une séquence d'algorithmes. Nous proposons un modèle éditorial distribué (“à la ... [more ▼]

Les articles du Französisches Etymologisches Wörterbuch (FEW) seront bientôt enrichis d'un balisage (XML) sémantique par une séquence d'algorithmes. Nous proposons un modèle éditorial distribué (“à la Wikipedia”) des corrections manuelles à apporter aux articles qui ne peuvent être automatiquement balisés. En outre, de manière à rendre totalement transparent pour les contributeurs le maintien de la consistance et de la synchronisation des trois quarts de million de documents considérés, nous proposons une plate-forme web de rétroconversion basée sur une architecture logicielle reposante (RESTful, cf. article Wikipedia sur REST). [less ▲]

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See detailL’idée du vote à 16 ans auprès des jeunes Belges francophones : mesurer les effets de la discussion sur l’évolution des opinions
Fournier, Bernard ULg; Darquenne, Raphaël ULg; Flaba, Elodie ULg

Conference (2009, May 28)

La question de l’abaissement du droit de vote à 16 ans a toujours fait l’objet de débats dans certains cercles universitaires. Lors des dernières élections autrichiennes, les jeunes de 16 ans et plus ont ... [more ▼]

La question de l’abaissement du droit de vote à 16 ans a toujours fait l’objet de débats dans certains cercles universitaires. Lors des dernières élections autrichiennes, les jeunes de 16 ans et plus ont été invités à voter même si les jeunes eux-mêmes sont souvent partagés, voire hostiles à l’idée. Or, une question comme le droit de vote à 16 ans, peu discutée publiquement et engageant plusieurs dimensions de la vie d’un individu, n’est-elle pas une question de débat idéale, où la confrontation des idées peut amener à modifier les points de vue et révéler – et même modifier – les attitudes plus globales des jeunes envers l’intérêt politique et la participation ? Partant d’un sondage aléatoire auprès des 15-21 ans en Belgique francophone, un sous-échantillon de 400 jeunes sera retenu pour discuter du vote à 16 ans, de l’intérêt et de leur participation politique lors d’une journée avec 5 experts. Le sondage initial sera redistribué pour mesurer l’impact de la discussion et des entretiens approfondis seront menés avec un sous-groupe pour étudier les mécanismes de socialisation politique. Ces premiers résultats sont présentés. [less ▲]

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See detailLimits imported from economics
Sibony, Anne-Lise ULg

Conference (2009, May 28)

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See detailConception d'algorithmes de rétroconversion
Renders, Pascale ULg; Briquet, Cyril

Conference (2009, May 28)

Rétroconvertir un ouvrage imprimé consiste à le transformer, de la manière la plus automatisée possible, en un ouvrage informatisé. Dans le cas d'un dictionnaire tel que le Französisches Etymologisches ... [more ▼]

Rétroconvertir un ouvrage imprimé consiste à le transformer, de la manière la plus automatisée possible, en un ouvrage informatisé. Dans le cas d'un dictionnaire tel que le Französisches Etymologisches Wörterbuch (FEW), il s'agit en outre de l'enrichir d'un balisage XML qui permette des consultations ciblées. Le noyau de l'opération est constitué de 37 algorithmes dits "de rétroconversion" qui balisent chacun un type d'information "cible" du dictionnaire. Cet article présente, en guise d'exemple, la mise au point de l'algorithme qui reconnaît et balise le(s) signataire(s) d'un article du FEW. [less ▲]

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See detailEmerging International Standards : If a dream could come true
Michel, Quentin ULg

Conference (2009, May 27)

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Peer Reviewed
See detailSelf-referential processing in future thinking
D'Argembeau, Arnaud ULg

Conference (2009, May 27)

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Peer Reviewed
See detailDe Duchamp à Mallarmé : réflexivité esthétique et réflexivité sociale
Durand, Pascal ULg

Conference (2009, May 26)

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See detailMeasuring Brand Image Perception and Changes in Brand Image Perception wth Brand Concept Maps - Capturing Strength, Uniqueness and Favourability of Brand Associations in Different Contexts
Brandt, Céline ULg

Conference (2009, May 26)

Recently, authors have emphasized the differences between brand images held by different individuals depending on the perception, the experience with the brand and the types of contacts with the company ... [more ▼]

Recently, authors have emphasized the differences between brand images held by different individuals depending on the perception, the experience with the brand and the types of contacts with the company. This finding is in sharp contrast with the conventional view recommending consistency and coherence in all the company’s actions. This research tradition has been called the consumer-focused view. Therefore, the author emphasized several academic motivations to develop research on brand image measurement on a consumer level. First, considering that different images are socially constructed constellations of meanings, established between marketers and consumers, with implications for both parties as well as for the marketplace and society at large, this phenomenon raises new issues in managing brand image: Should the company define segments with different brand perceptions and adapt its strategy to these perceptions, how can the city council satisfy the different stakeholders of a city brand, to what extent does the launch of a junior brand influence the perception of a senior brand with a similar name, to what extent do opinion leaders and antibrand activists influence the perception of a corporate brand. Second, there is a need for a process-oriented methodology, namely one that recognizes changes in brand images due to all the influences in the marketplace, to measure the brand perception and capture any change in the brand perception that is due to external factors, namely factors that are not decided by the company. Third, considering the link between brand image and brand equity, the method should focus on the contribution of attributes to brand equity, capturing the strengths, uniqueness and the favourability of these associations. And fourth, regarding the varied natures of brand attributes (functional, emotional, people, ethics, etc) depending on the type of brand (product brand, service brand, city brand and corporate brand), this technique to assess brand image perception should be applicable to all kinds of brands. As a result, the overall objective of this research is to provide profound insight into a measurement method of brand image perception and changes in brand image perception, capturing the strengths, uniqueness and favorability of brand attributes in different contexts, as a consequence of the new consumer focused and process-oriented views. [less ▲]

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See detailQuelle politique fiscale internationale pour la Belgique?
Richelle, Isabelle ULg; TRAVERSA, Edoardo

Conference (2009, May 25)

Les activités économiques se développent au-delà des frontières. Les contribuables se trouvent soumis à différents systèmes fiscaux, ce qui multiplie les situations de double imposition internationale ... [more ▼]

Les activités économiques se développent au-delà des frontières. Les contribuables se trouvent soumis à différents systèmes fiscaux, ce qui multiplie les situations de double imposition internationale. Les conventions bilatérales ont comme objectif d'en limiter les effets. Les différentes méthodes utilisées laissent cependant subsister certaines situations de double imposition. [less ▲]

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See detailArchaeomagnetic study performed on early medieval buildings from western France
Chauvin, Annick; Lanos, Philippe; Dufresne, Philippe et al

Conference (2009, May 25)

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See detailDegradation mechanisms of Pt/C electrocatalysts at the nm-scale
Maillard, F.; Vion-Dury; Solhy, K. et al

Conference (2009, May 24)

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See detailSurra-induced lymphopenia is directly triggered by a membrane-associated parasite protein
Antoine-Moussiaux, Nicolas ULg; Cornet, Anne ULg; Cornet, François et al

Conference (2009, May 24)

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See detailGiving up the Ghosts: Diaspora and its Hereafter in “Once in a Lifetime” by Jhumpa Lahiri
Munos, Delphine ULg

Conference (2009, May 23)

In spite of diasporic subjectivity being recurrently conceptualised through a rhetoric of “fluidity,” “multiple affiliations” and “national non-attachment,” today’s literature of the Indian diaspora ... [more ▼]

In spite of diasporic subjectivity being recurrently conceptualised through a rhetoric of “fluidity,” “multiple affiliations” and “national non-attachment,” today’s literature of the Indian diaspora reveals that the “un-transnational” ideology of the return is still running deep in the first and second-generation migrant imaginary. Vijay Mishra’s recent attempt to explore the idea of “writing diaspora” in an analogy with writing trauma or writing mourning is illuminating in this respect, because it constitutes a theoretical framework able to bear witness to the maintenance of a diasporic imaginary structured by the loss of the Motherland, whether this loss involves firsthand experience of migration or originates from a “phantom loss” refigured by the second generation. Drawing on Mishra’s theorizing of the diasporic imaginary, my paper will explore Jhumpa Lahiri’s representation of the second generation’s “inheritance of loss” in “Once in a Lifetime,” the short-story opening Unaccustomed Earth’s trilogy. By narrating Hema’s and Kaushik’s parallel journey from childhood to early adulthood, Lahiri rewrites the notion of return as melancholic attachments through which the unsymbolizable gap left by the absence of the Motherland can be represented, renegotiated and perhaps then, put to rest. In my paper, I wish to show that not only does Lahiri use melancholy as a means of representing second-generation subjectivities haunted by impossible mourning and unclaimed legacies, but also that she rehabilitates the notion of return as a way of envisaging a diasporic future that is swarming with ghosts. In that sense, Lahiri illustrates that the notion of homeland and the trope of the return can also be associated with a promise of futurity. [less ▲]

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See detailThe European Union Implementation of Sustainable Development
Michel, Quentin ULg

Conference (2009, May 22)

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See detailBehaviour of Deep Reinforced Concrete Beams under Monotonic and Reversed Cyclic Loading
Mihaylov, Boyan ULg; Bentz, Evan; Collins, Michael

Conference (2009, May 22)

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See detailCe qui "nous" force à penser. Proust 1943-1964
Cormann, Grégory ULg

Conference (2009, May 22)

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See detailUse of the supercritical fluid technology to prepare efficient nanocomposite foams for environmental protection purpose
Urbanczyk, Laetitia ULg; Thomassin, Jean-Michel ULg; Huynen, Isabelle et al

Conference (2009, May 19)

This work reports on the preparation of novel nanocomposite foams that are efficient broadband microwave absorbers. Carbon nanotubes are first successfully dispersed into PCL and PMMA by melt blending ... [more ▼]

This work reports on the preparation of novel nanocomposite foams that are efficient broadband microwave absorbers. Carbon nanotubes are first successfully dispersed into PCL and PMMA by melt blending. Then, foaming is promoted by supercritical CO2 by depressurization. Regular cellular structures are obtained in both cases with cells size around 10-50µm. The electromagnetic interference (EMI) shielding efficiency of these materials are then evaluated and compared to the non-foamed nanocomposites. [less ▲]

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See detailDevelopment of a small-scale scroll expander-based ORC
Quoilin, Sylvain ULg

Conference (2009, May 19)

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See detailInfluence function of the error rate of classification based on clustering
Ruwet, Christel ULg; Haesbroeck, Gentiane ULg

Conference (2009, May 19)

Cluster analysis may be performed when one wishes to group similar objects into a given number of clusters. Several algorithms are available in order to construct these clusters. In this talk, focus will ... [more ▼]

Cluster analysis may be performed when one wishes to group similar objects into a given number of clusters. Several algorithms are available in order to construct these clusters. In this talk, focus will be on two particular cases of the generalized k-means algorithm : the classical k-means procedure as well as the k-medoids algorithm, while the data of interest are assumed to come from an underlying population consisting of a mixture of two groups. Among the outputs of these clustering techniques, a classification rule is provided in order to classify the objects into one of the clusters. When classification is the main objective of the statistical analysis, performance is often measured by means of an error rate. Two types of error rates can be computed: a theoretical one and a more empirical one. The first one can be written as ER(F, Fm) where F is the distribution of the training sample used to set up the classification rule and Fm (model distribution) is the distribution under which the quality of the rule is assessed (via a test sample). The empirical error rate corresponds to ER(F, F), meaning that the classification rule is tested on the same sample as the one used to set up the rule. This talk will present the results concerning the theoretical error rate. In case there are some outliers in the data, the classification rule may be corrupted. Even if it is evaluated at the model distribution, the theoretical error rate may then be contaminated. To measure the robustness of classification based on clustering, influence functions have been computed. Similar results as those derived by Croux et al (2008) and Croux et al (2008) in discriminant analysis were observed. More specifically, under optimality (which happens when the model distribution is FN = 0.5 N(μ1, σ) + 0.5 N(μ2, σ), Qiu and Tamhane 2007), the contaminated error rate can never be smaller than the optimal value, resulting in a first order influence function identically equal to 0. Second order influence functions need then to be computed. When the optimality does not hold, the first order influence function of the theoretical error rate does not vanish anymore and shows that contamination may improve the error rate achieved under the non-optimal model. The first and, when required, second order influence functions of the theoretical error rate are useful in their own right to compare the robustness of the 2-means and 2-medoids classification procedures. They have also other applications. For example, they may be used to derive diagnostic tools in order to detect observations having an unduly large influence on the error rate. Also, under optimality, the second order influence function of the theoretical error rate can yield asymptotic relative classification efficiencies. [less ▲]

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See detailExtending the job Demands-Resources Model : safety behaviour and perceived safety climate.
Hansez, Isabelle ULg; Chmiel, N.

Conference (2009, May 16)

Detailed reference viewed: 18 (2 ULg)
See detailLa couleur des dehors dans les traités d’architecture français, XVIe-XVIIIe siècle
Gilles, Isabelle ULg

Conference (2009, May 15)

Témoin fondamental pour l’étude du bâti, le traité d’architecture constitue une source textuelle et iconographique, et plus généralement un document contextuel, qui détermine les règles de l’architecture ... [more ▼]

Témoin fondamental pour l’étude du bâti, le traité d’architecture constitue une source textuelle et iconographique, et plus généralement un document contextuel, qui détermine les règles de l’architecture dans ses dimensions les plus vastes : culturelles, sociales, économiques, techniques… Ainsi, dans le domaine de la « peinture d’impression », les auteurs nous livrent aussi bien des informations d’ordre technique (matières et mises en œuvre) que les usages d’une architecture pensée et écrite avec soin, dans laquelle chaque élément – et chaque couleur – occupe une place bien déterminée. Si la couleur des « dedans » prend naturellement le dessus dans une conception française de l’architecture qui a poussé au plus haut point l’art de la distribution, la couleur des « dehors » n’est néanmoins pas négligée. Aussi trouverons-nous dans les traités d’architecture les techniques et les usages qui conviennent aux « dehors » ; informations qui sont susceptibles de guider le restaurateur dans les choix d’intervention qu’il projette sur le bâti ancien. [less ▲]

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See detailLes principles de l’Eco-conception
Reiter, Sigrid ULg

Conference (2009, May 15)

Detailed reference viewed: 72 (11 ULg)
See detailA Systems Biology Approach to Apoptosis Signalling
Schliemann, Monica ULg; Scheurich, Peter; Bullinger, Eric ULg

Conference (2009, May 15)

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See detailLes stratégies wallonnes en matière de simplification administrative
Thoreau, François ULg

Conference (2009, May 15)

Detailed reference viewed: 21 (2 ULg)
Peer Reviewed
See detailLes standards internationaux : la place des situations et des contextes
Lafontaine, Dominique ULg

Conference (2009, May 15)

Detailed reference viewed: 5 (0 ULg)