References of "Unpublished conference/Abstract"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailHigh-throughput sequencing of toxins with pharmacological interest: proof of concept and first applications
Echterbille, Julien ULg; Degueldre, Michel ULg; Boulanger, Madeleine ULg et al

Conference (2015, September 28)

Animal venoms are complex chemical cocktails, comprising wide ranges of biologically active reticulated peptides that target with high selectivity and efficacy varieties of membrane receptors. Assuming ... [more ▼]

Animal venoms are complex chemical cocktails, comprising wide ranges of biologically active reticulated peptides that target with high selectivity and efficacy varieties of membrane receptors. Assuming the fact that each of the 170,000 venomous species reported can produce more than 250 bioactive toxins, at least 40,000,000 bioactive peptides and proteins may be discovered. Among the four described species of mambas, Eastern Jameson’s mamba (Dendroaspis jamesonii kaimosae) venom is the less characterized since only 9 peptides are referenced in database. This work aims at developing a new strategy devoted to the deep analysis of animal venoms. Our approach consists in a first separation of the venom using cation exchange chromatography. Each primary fraction is then purified a second time by classical RP-HPLC. A total of 328 fractions, containing amongst 1 and 4 toxins, are finally collected. MALDI-MS analysis of each fraction is done in order (1) to obtain information about masses and (2) to obtain sequences of toxins thanks to MALDI-In Source Decay (ISD) dissociation coupled with on MALDI target plate reduction of the peptides. ISD has already been demonstrated efficient for toxin sequencing1, and especially when using 1,5-DAN as reducing matrix2. ISD yields to sequences that cover more than 50% of peptide sequences by series of singly charged c-type ions. Thanks to this methodology, we were able to obtain 85% of satisfactory results i.e. spectra giving quite long tags of amino acids (up to 20 residues). As a way to validate our method, a tag coming from ISD spectrum interpretation has found a match in database for an Eastern Jameson’s mamba toxin. The global sequence has then been obtained by extrapolation on the ISD spectrum. Since ISD spectra are simpler than classical MS/MS spectra, automation of spectra interpretation, difficult with other fragmentation techniques (CID, ETD…), is implementable. In the near future, sequences obtained with this approach will be used to direct tests of biological activity through sequence homologies with already known ligands for different kinds of membrane receptors. [less ▲]

Detailed reference viewed: 28 (7 ULg)
See detailPsychological benefits of a multidisciplinary rehabilitation program after breast cancer
Leclerc, Anne-France ULg; FOIDART-DESSALLE, Marguerite ULg; Bury, Thierry ULg et al

Conference (2015, September 27)

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined ... [more ▼]

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined. However, the disease and its treatments are at the origin of many undesirable side effects such as fatigue, anxiety, weight gain and sleep disorders. The objective of this study is to determine the psychological benefits of a multidisciplinary rehabilitation program among women treated for breast cancer (on average six months after the end of the adjuvant radiotherapy or chimiotherapy). Material and methods : 122 patients were included into a control group (n = 61) and a treated group (n = 61). All participants were submitted to evaluations before the beginning of the trial and after three months. These evaluations included different questionnaires exploring the quality of life, anxiety, depression and various functions and other symptoms related to cancer (EORTC QLQ-C30, EQ-5D, STAI, HADS) and functional assessments. The control group has received no intervention unlike the treated group that received a three-month rehabilitation including supervised physical training (90 min) with three times a week and various psycho-educational sessions (120 min) once a week. Results : After three months, the health status (quality of life) (p < 0,0001), the functional role (p = 0,031), emotional state (p < 0,0001) and physical (p = 0,0045), cognitive (p = 0,0027) and social functions (p = 0,0018) improve significantly in the treated group. This observation also applies to symptoms of fatigue (p < 0,0001), insomnia (p < 0,0001), pain (p = 0,002), dyspnea (p = 0,009), loss of appetite (p = 0,04), anxiety (p < 0,0001) and depression (p < 0,0001) as well as physical parameters obtained through functional assessments. In the control group, these improvements do not appear. Conclusions : This study shows the feasibility and psychological benefits of such a multidisciplinary oncological rehabilitation program in women after their treatments for breast cancer. Additional studies are needed to know the optimal time of beginning (during treatments or after them) and the optimal management time for this support. [less ▲]

Detailed reference viewed: 118 (26 ULg)
Full Text
See detailHypoxic ischemic encephalopathy : new insights in neuroprotection
VIELLEVOYE, Renaud ULg

Conference (2015, September 26)

Hypoxic-ischemic encephalopathy (HIE) is a major contributor to neonatal morbidity and mortality and is a common cause of disability with devastating impact on individuals and families. During the acute ... [more ▼]

Hypoxic-ischemic encephalopathy (HIE) is a major contributor to neonatal morbidity and mortality and is a common cause of disability with devastating impact on individuals and families. During the acute phase, HIE is initially characterized by an excitotoxic cascade with hypoxic membrane depolarization, cytotoxic edema, glutamate release and intracellular accumulation of calcium leading to necrotic cell death and production of proinflammatory cytokines through the NF-κB pathway. In a second phase, reperfusion leads to production of free radicals, activation of proteases and phospholipases, exacerbing the damage to cell membrane and DNA and mitochondrial dysfunction causing caspase mediated apoptotic cell death. In a third phase, growth factors and inflammatory cytokines produced during the early phase of HIE attempt to repair damage induced by hypoxia–ischemia. Although the utility of therapeutic hypothermia induced in the 6 hours following HIE in the reduction of death or major neurodevelopmental disability is now well established in the neonate with moderate or severe encephalopathy, almost half of these children still die or have abnormal outcomes [1]. Protocols attempting to optimize cooling with deeper hypothermia (33.5°C vs 32.0°C) and/or longer duration (72h vs 120h), as well protocols studying neuroprotective effect of late hypothermia (6-24h) or hypothermia for 33-35 week GA preterm babies are currently performed. Furthermore, experimental data suggest that hypothermia extends the duration of the therapeutic window [2] and that certain drugs given during this time may improve neuroprotection either additively or synergistically. Xenon is a noble gas with anaesthetic and neuroprotective properties. It inhibits NMDA receptor, promotes cell survival and induces the production of erythropoietin and vascular endothelial growth factor through the hypoxia inducible factor 1 alpha (HIF-1α) pathway. Data from experimental piglet models of hypoxia-ischemia (HI) demonstrate a synergy when Xenon is administered in combination with mild therapeutic hypothermia [3]. In the human newborn, a phase-1 trial recently established that breathing 50% Xenon for up to 18 hours with 72 hours of cooling was feasible, with no adverse effects seen with 18 months’ follow-up [4]. A monocentric phase-3 trial is currently under process in England. Melatonin is a remarkable natural antioxidant but also exhibits antiapoptotic and anti-inflammatory properties in vitro. In animal models, melatonin administration prior or after the onset of HI significantly reduced infarct volume demonstrating both prophylactic and therapeutic effect [5-6]. When combined with hypothermia, melatonin enhances neuroprotection by reduction of the H–I-induced increase in clinically relevant biomarkers in the deep grey matter of newborn piglets [7]. Clinical studies confirmed its safety profile and its ability to reduce biomarkers level of HI in the human newborn [8]. Recently, a randomized controlled trial showed that the combination of melatonin and hypothermia administered to infants with moderate-to-severe H–I brain injury was efficacious in reducing oxidative stress, neonatal seizures and MRI brain lesions as well as in improving neurological outcomes at 6 months of age [9]. Erythropoietin (EPO) and its receptor are expressed in the developing central nervous system and are required for normal brain development. EPO is up-regulated in umbilical cord blood from babies who have suffered HI, which may be an endogenous repair mechanism. In vitro and in vivo neuroprotection induced by EPO is achieved by several mechanisms such as direct neurotrophic effect, direct antioxidant effects, decreased inflammation or regulation between pro-apoptotic and anti-apoptotic factors. Safety profile of EPO administration during hypothermia for newborns with HIE has been established in Phase I trials [10]. In a randomized prospective pase-2 trial, repeated low-dose rEPO reduced the risk of disability for infants with moderate but not severe HIE at 18 months, without apparent side effects [11]. A double-blind randomized controlled phase-3 trial is currently performed in France. Allopurinol is a xantine-oxidase inhibitor. In high concentrations it also scavenges hydroxyl radicals and prevents free radical formation. Allopurinol provides neuroprotection in rat and piglets models of HIE. In the human, a systematic review and meta-analysis of three studies on 114 newborns did not reveal statistically difference in the risk of death or a composite of death or severe neurodevelopmental disability between groups [12]. It was hypothesized that postnatal allopurinol treatment started too late to reduce reperfusion-induced free radical surge. However, in a recent study, allopurinol given to mothers during labor with fetal hypoxia did not significantly lower neuronal damage markers in cord blood even if post hoc analysis revealed a potential beneficial treatment effect in girls [13]. Magnesium sulfate (MgSO4) is a naturally occurring NMDA receptor antagonist. MgSO4 given to mothers at risk for preterm birth is associated with a reduced risk of cerebral palsy and gross motor dysfunction in their children. Its role as an adjuvant to therapeutic hypothermia in the asphyxiated term infant remains unclear. A recent review of preclinical studies using MgSO4 in HIE highlights the inconsistent impact between studies related to a lack of temperature control during and after HI, along with variability in the dose, timing of treatment [14]. A metaanalysis of five randomized controlled trials that compared magnesium to control in newborns with HIE showed a significant improvement in short term outcomes but no difference in the composite outcome of death or moderate to severe disability at 18 months [15]. Other NMDA and AMPA antagonist such as topiramate and memantine also exhibited neuroprotective properties in animal models but safety and efficacy in the human newborn with HIE still needs to be clarified [16]. N-acetyl cysteine (NAC) acts as a glutathione precursor with antioxidant, antiapoptotic, and anti-inflammatory properties. In a piglet model of HIE, NAC reduced cerebral oxidative stress, reduced cerebral lactate accumulation and improved cerebral perfusion. When combined with hypothermia in the asphyxiated rodent, NAC decreased infarct volume, improved myelin expression and functional outcomes on a synergistic pattern. NF-κB inhibitors and NO synthase inhibitors are other therapeutic options currently under investigation in in vitro and in vivo preclinical studies. Moreover, recent research performed at the University of Liege also suggests that Estetrol (E4), an estrogen synthetized exclusively by the human foetus, has neuroprotective properties in a rat model of HIE. Translation to clinical use in humans still needs to be studied [17]. Several therapies have also been suggested in order to improve mechanisms of repair and regeneration observed after the HI insult. Growth factors such as BDNF, IGF-1, EGF or bFGF can improve cell viability, stimulate the growth of new neurons or promotes oligodendroglial differentiation and myelination. Recent advances in regenerative medicine suggest that stem cell transplantation may improve repair of the damaged brain after HIE through the replacement of dead cells as well as through the release of trophic factors [18]. Animal preclinical data are promising. However many questions need to be answered with well-designed controlled trials before clinical application in daily practice. References [1] Edwards AD et al. (2010) Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ. 340:c363. [2] O'Brien F et al. (2006) Delayed whole-body cooling to 33 or 35 degrees c and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. Pediatrics 117:1549–59. [3] Chakkarapani, E. et al. (2010) Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Ann. Neurol. 68, 330–341 [4] Dingley, J. et al. (2014) Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study. Pediatrics 133, 809–818 [5] Carloni, S. et al. (2008) Melatonin protects from the long-term consequences of a neonatal hypoxic–ischemic brain injury in rats. J. Pineal. Res. 44, 157–164 [6] Hutton, L.C. et al. (2009) Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomyscahirinus). Dev. Neurosci. 31, 437–451 [7] Robertson, N.J. et al. (2013) Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain 136, 90–105 [8] Fulia, G. et al. (2001) Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. Journal of Pineal Research; 31(4):343–349. [9] Aly, H. et al. (2015) Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. J. Perinatol. 35, 186–191 [10] Wu, Y.W. et al. (2012) Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics. Pediatrics 130, 683–691 [11] Zhu, C. et al. (2009) Erythropoietin improved neurologic outcomes in newborns with hypoxic–ischemic encephalopathy. Pediatrics 124, 218–226 [12] Chaudhari, T. and McGuire, W. (2012) Allopurinol for preventing mortality and morbidity in newborn infants with hypoxic–ischaemic encephalopathy. Cochrane Database Syst. Rev. 7, Cd006817 [13] Kaandorp, J.J. et al. (2015) Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial. Arch. Dis. Child Fetal Neonatal Ed. 100, F216–F223 [14] Galinsky, R. et al. (2014) Magnesium is not consistently neuroprotective for perinatal hypoxia-ischemia in term-equivalent models in preclinical studies: a systematic review. Dev. Neurosci. 36, 73–82 [15] Tagin, M. et al. (2013) Magnesium for newborns with hypoxic–ischemic encephalopathy: a systematic review and meta-analysis. J. Perinatol. 33, 663–669 [16] Wu, Q et al. (2015) Neuroprotective agents for neonatal hypoxic–ischemic brain injury. Drug Discovery Today. [17] Tskitishvili, E et al. (2014). Estetrol attenuates neonatal hypoxic–ischemic brain injury. Experimental Neurology, 261, 298-307. [18] Kelen, D and Robertson, NJ. (2010) Experimental treatments for hypoxic ischaemic encephalopathy. Early Human Development 86; 369–377. [less ▲]

Detailed reference viewed: 148 (0 ULg)
Peer Reviewed
See detailHabitants des petites villes et des villages face à la nature dans les paysages ordinaires
Vanderheyden, Vincent ULg

Conference (2015, September 25)

La recherche sur les perceptions paysagères dénigre souvent les paysages ordinaires, ces paysages modifiés par l’homme qui n’appellent pas à la protection. Pourtant, dans les régions de forte densité de ... [more ▼]

La recherche sur les perceptions paysagères dénigre souvent les paysages ordinaires, ces paysages modifiés par l’homme qui n’appellent pas à la protection. Pourtant, dans les régions de forte densité de population comme la Belgique, les paysages naturels sont rares ou inexistants, sans pour autant que la nature ait disparu des paysages ordinaires. Il est donc intéressant de se poser la question de la nature dans de tels paysages : à partir de quand un paysage est-il perçu comme naturel par ceux qui l’observent ou y vivent ? Les critères dépendent-ils du mode d’habiter (petite ville, village périurbain ou village rural) ou d’autres facteurs liés à la trajectoire biographique des gens ? Trois terrains d’études ont été retenus pour la recherche : la Wallonie picarde, l’Entre-Sambre et Meuse et l’Ardenne. Ces terrains offrent des paysages ruraux assez typés et suffisamment différenciés et éloignés des grandes agglomérations urbaines, hormis Tournai, ville d’envergure régionale. La Wallonie picarde présente des paysages de vastes plateaux agricoles limoneux au relief plan et peu élevé, occasionnellement surplombé de petites collines. L’Entre-Sambre-et-Meuse offre des paysages mixtes, alternant cultures, prairies et boisement dans un relief plus accidenté d’altitude moyenne. Enfin, l’Ardenne, troisième terrain, montre des paysages de hauts plateaux disséqués, dominés par les massifs forestiers et les pâturages. Ces terrains offrent un bel aperçu du continuum urbain-rural belge : de la petite ville en milieu rural au semis d’habitat très lâche du village ardennais, loin de l’habituelle dichotomie ville - campagne. Dans ces terrains, une approche empirique a été privilégiée. Nous y avons interviewé trois groupes de neuf étudiants (18-25 ans) d’un niveau d’éducation moyen (Bac +1 à Bac +3), non spécialistes en analyse du paysage, habitant dans de petites villes ou villages et un de leurs parents. Durant l’enquête, les personnes devaient classer des photos de paysages ruraux belges plus ou moins impactés par la présence de l’homme (habitat, cultures, éoliennes, pylônes, zones périurbaines) puis devaient motiver leur classement. Les entretiens ont été enregistrés, retranscrits et codés à l’aide d’un logiciel d’analyse qualitative. L’analyse de contenu montre des résultats contrastés. Un certain consensus indépendant du mode d’habiter semble se dégager concernant la présence d’éléments anthropiques récents, tels quel les éoliennes, les zones industrielles ou les pylônes électriques : cela participe à la dénaturation d’un paysage, avec une subtile nuance pour les éoliennes, où la symbolique positive écologique peut pour certains contrebalancer la perte de naturalité induite. Chez des personnes vivant dans un milieu plus urbanisé, le paysage naturel attire, car il change des habitudes de vie. Certains n’hésitent pas à qualifier un paysage de naturel pour peu qu’il contienne suffisamment de végétation, fusse une vaste étendue agricole dédiée à la monoculture. Chez des personnes vivant dans des milieux très ruraux par contre, on ne constate pas toujours la tendance inverse : même la petite ville voisine semble parfois trop urbanisée à leurs yeux pour y vivre. A leurs yeux, les paysages deviennent moins attractifs au fur et à mesure que la densité du bâti devient perceptible. Plus qu’une analyse du visuel, cette recherche montre également que les gens s’imaginent être dans le paysage, entendant les bruits ou ressentant une perte de convivialité à mesure que le paysage s’industrialise ou se remplit de maisons. [less ▲]

Detailed reference viewed: 29 (5 ULg)
See detailEn tous quartiers ou j’ay esté. Le récit de pèlerinage de Georges Lengherand, mayeur de Mons (1486–1487)
Bruwier, Marie-Cécile; Docquier, Gilles; Marchandisse, Alain ULg

Conference (2015, September 25)

Detailed reference viewed: 16 (2 ULg)
See detailPhysicochimie de la pollution atmosphérique
Mahieu, Emmanuel ULg

Conference (2015, September 25)

Detailed reference viewed: 25 (6 ULg)
See detailBaltic seagrass meadows as a sediment carbon sink
Jankowska, Emilia; Włodarska-Kowalczuk, Maria; Michel, Loïc ULg et al

Conference (2015, September 25)

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailOn generalized Hölder spaces
Kreit, Damien; Nicolay, Samuel ULg

Conference (2015, September 24)

We introduce generalized pointwise Hölder spaces as the point wise version of generalized uniform Hölder spaces. These last ones can be seen as a special case of generalized Besov spaces.

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailPerformances of a simple exhaust mechanical ventilation coupled to a mini heat pump: modeling and experimental investigations
Ransy, Frédéric ULg; Gendebien, Samuel ULg; Lemort, Vincent ULg

Conference (2015, September 24)

According to the European directive 2012/27/EU of October 2012 on energy efficiency, buildings represented 40 % of the EU’s final energy consumption in 2011. The major part of this energy consumption is ... [more ▼]

According to the European directive 2012/27/EU of October 2012 on energy efficiency, buildings represented 40 % of the EU’s final energy consumption in 2011. The major part of this energy consumption is due to the residential sector for space heating and domestic hot water production. Moreover, buildings are crucial to achieve the EU objective of reducing greenhouse gas emissions by 80-95 % by 2050 compared to 1990. In order to reduce these greenhouse gas emissions, retrofit measures regarding insulation and air-tightness have to be taken. However, such improvements of the building envelope lead to a relative increase in consumption related to ventilation. Indeed, according to Orme (2001), Roulet et al. (2001) and Fouih et al. (2012), the heating demand due to ventilation can reach more than 50 % of the total building heating demand for new and retrofitted buildings. To reduce the energy consumption due to ventilation, exhaust air heat pumps (EAHPs) can be used instead of the traditional heat recovery with an air-to-air heat exchanger. EAHPs recover heat from the exhaust air of the ventilation system to produce domestic hot water and space heating. According to Fehrm et al. (2002), this technology is already widely used in the northern countries such as Germany and Sweden. In fact, according to Fracastoro et al. (2010), efficiencies of EAHPs are higher than those obtained with outside air or geothermal heat pumps in certain conditions, whatever the climate location. Berg et al. (2010) have monitored three houses in Sweden equiped with exhaust air heat pumps. The seasonal performance factor (SPF) values were all within the range 1.4-1.7. This factor takes into account the energy consumption of the heat pumps and the auxiliary heating systems. A 17 kW exhaust air heat pump has also been tested by Mikola et al. (2014). The measured SPF for the heat pump only (without taking into account the auxiliary heating system) was about 2.9-3.4 in winter and 3 in the summer. Exhaust air heat pumps coupled with simple exhaust mechanical ventilation systems have many advantages compared to traditional balanced systems with heat recovery: • Only one fan is necessary and the duct system is simpler. Consequently, EAHPs are suitable for retrofitted buildings. • The heat pump can provide the whole part of the heating demand related to domestic hot water and 50 % of the heating demand related to space heating, according to Fracastoro et al. (2010). • The heat pump can also provide active cooling by inversing the refrigerating cycle. • The heat pump performance is high and remains constant with outdoor temperature changes since the temperature of the heat sink is constant (20°C). As a result, the system is cost-effective. • The system is compact, quiet and requires little maintenance. In the present paper, the energetic performances of an exhaust air heat pump are assessed through numerical and experimental studies. The thermal capacity of the machine is 1.5 kW when the inside air temperature is 20°C and the outside water temperature is 35°C. The heat pump is therefore ideally suited for new or retrofitted buildings. The system including a mechanical exhaust ventilation system and an exhaust air heat pump is first presented. Secondly, the heat pump model used afterwards to determine the heat pump seasonal performance factor is described. Thirdly, the model is calibrated to fit the measurement data. Finally, the heat pump model is coupled to a building model to determine the annual performance of the system. The system is compared to a traditional balanced ventilation system with heat recovery in terms of primary energy consumption, for different heating and DHW production systems (electric heater, heat pump, gas condensing boiler). [less ▲]

Detailed reference viewed: 101 (32 ULg)
Full Text
See detailVALIDATION RELEVANCE OF ANALYTICAL METHODS IN BIOTECHNOLOGY
Marini Djang'Eing'A, Roland ULg; Hubert, Philippe ULg

Conference (2015, September 24)

Detailed reference viewed: 25 (5 ULg)
See detailMedicinal plants, malaria and biotechnology
Frederich, Michel ULg; Jansen, Olivia ULg; Muganga, Raymond et al

Conference (2015, September 24)

The first part of the talk will be dedicated to the investigation of medicinal plants with the objective to identify new antimalarial treatments. According to the last World Malaria Report [1], there were ... [more ▼]

The first part of the talk will be dedicated to the investigation of medicinal plants with the objective to identify new antimalarial treatments. According to the last World Malaria Report [1], there were 584 000 deaths for 198 millions malaria cases worldwide in 2013. Particularly, the disease caused an estimated 437 000 African children died before their fifth birthday, still in 2013. Malaria is caused by a parasite, Plasmodium sp. and transmitted by Anopheles mosquitoes. The problem of parasite resistance towards common available medicines such as chloroquine, mefloquine, quinine, is increasing. In this context, the vegetal kingdom remains the main source of pharmacologically active compounds against this parasitic infection as attested by the famous quinine, isolated from Cinchona sp., artemisinin extracted from Artemisia annua and also atovaquone derived from lapachol found in several Bignoniaceae. All these substances are related to plants with traditional use against fever and malaria. Beside these well-known examples, various new antiplasmodial compounds are frequently discovered from Nature, particularly following an ethnopharmacological approach, as reviewed by several authors in recent years [2-6]. Then, the pharmacological and phytochemical study of plants from traditional pharmacopoeias can be of first interest not only to discover new antimalarial “lead compounds”, but also to valorize local vegetal species whose efficacy and safety would have been demonstrated in laboratory and by clinical investigations [7,8]. Some results obtained with Dicoma tomentosa from Burkina-Faso [9] and Terminalia mollis from Rwanda [10] will be presented. In the second part of the talk, two applications of biotechnology for the production of artemisinin and paclitaxel and then some works developed at the ‘Université de la Réunion’ will be presented. In the framework of this collaboration, Psiadia arguta, an endemic plant from Reunion Island, which is known to have cytotoxic, anti-plasmodial and anti-inflammatory properties, was subjected to micropropagation. The objective of the work was to compare the biological properties and the phytochemical composition of callus, vitroplants and acclimatized plants of Psiadia arguta [11]. 1. WHO, World Malaria Report 2014, December 2014, Geneva (http://www.who.int/malaria/publications/world_malaria_report_2014/en/). 2. Batista R, Silva Ade J Jr, de Oliveira AB: Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products. Molecules 2009, 14:3037-72. 3. Bero J, Frédérich M, Quetin-Leclercq J : Antimalarial compounds isolated from plants used in traditional medicine. Journal of Pharmacy and Pharmacology 2009, 61:1401–1433. 4. Bero J and Quetin-Leclercq J: Natural products published in 2009 from plants traditionally used to treat malaria. Planta Medica 2011, 77:631-40. 5. Kaur K, Jain M, Kaur T, Jain R: Antimalarials from nature. Bioorganic & Medicinal Chemistry 2009, 17:3229–3256. 6. Nogueira CR and Lopes LMX: Antiplasmodial Natural Products. Molecules 2011, 16:2146-2190 7. Ginsburg H and Deharo E: A call for using natural compounds in the development of new antimalarial treatments – an introduction. Malaria Journal 2011, 10 (suppl. 1):S1 8. Willcox M, Graz B, Falquet J, Diakite C, Giani S, Diallo D: A “reverse pharmacology” approach for developing an antimalarial phytomedicine. Malaria journal 2011, 10(suppl1):S8 9. Jansen, O., Tits, M., Angenot, L., Nicolas, J.-P., De Mol, P., Nikiema, J.-B., & Frédérich, M : Anti-plasmodial activity of Dicoma tomentosa (Asteraceae) and identification of urospermal A-15-O-acetate as the main active compound. Malaria Journal 2012, 11, 289. 10. Muganga, R., Angenot, L., Tits, M., & Frédérich, M : In vitro and in vivo antiplasmodial activity of three Rwandan medicinal plants and identification of their active compounds. Planta Medica 2013, 80(6), 482-489. 11. Mahy Justine, Comparative study of biological activities and analysis of volatile compounds of Psiadia arguta in various cultures: vitroplants and acclimatized plants. Mémoire de M2, 2013, Université de Liège/Université de la Réunion. [less ▲]

Detailed reference viewed: 149 (7 ULg)
Peer Reviewed
See detailGrowth factors-induced angiogenesis requires the uPAR on the endothelial cells
Paques, Cécile ULg

Conference (2015, September 24)

Detailed reference viewed: 11 (1 ULg)
See detailPerformances analytiques d’un biomarqueur : dialogue
CAVALIER, Etienne ULg

Conference (2015, September 23)

Detailed reference viewed: 12 (1 ULg)
Full Text
See detailStratospheric HCl increasing again, caused by dynamic variability, driven by increased tropopsheric wave activity
Notholt, J; Mahieu, Emmanuel ULg; Pfloeger, F et al

Conference (2015, September 22)

Detailed reference viewed: 18 (2 ULg)
See detailAir-sea ice gases exchange: update of recent findings, outcomes from sea ice models, caveats and open questions
Delille, Bruno ULg; Zhou, Jiayun; Kotovitch, Marie ULg et al

Conference (2015, September 21)

There are growing evidences that sea ice exchanges climate gases with the atmosphere. We will rapidly present a state of the art of current large scale assessment of spring and summer uptake of ... [more ▼]

There are growing evidences that sea ice exchanges climate gases with the atmosphere. We will rapidly present a state of the art of current large scale assessment of spring and summer uptake of atmospheric CO2. We will challenge these assessments with 1) new evidence of significant winter CO2 release for winter experiments 2) new finding of the role of bubbles formation and transport within sea ice and 3) impurities expulsion derived from combined artificial ice experiment and modelling. Finally, comparison of air-ice fluxes derived from automated chamber and micrometeorological method and, mechanistic and box models show significant discrepancies that suggest that the contribution of sea ice to the air-ocean fluxes of CO2 remain an open question. We will also highlight that sea ice contribute to the fluxes of other gases as CH4 ,N2O and DMS [less ▲]

Detailed reference viewed: 32 (6 ULg)
Full Text
See detailUse of Near Infrared Hyperspectral Imaging in studies on root systems
Eylenbosch, Damien ULg; Fernández Pierna, Juan Antonio; Fraipont, Guillaume ULg et al

Conference (2015, September 21)

Detailed reference viewed: 18 (9 ULg)
See detailPathways of recurrent high-grade squamous intraepithelial lesions of the cervix
Herfs, Michael ULg

Conference (2015, September 20)

Detailed reference viewed: 10 (2 ULg)
Peer Reviewed
See detailNon-invasive markers: the role of G-CSF?
Munaut, Carine ULg

Conference (2015, September 19)

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailThe importance of physical educators’ representations about physical activity
Cloes, Marc ULg

Conference (2015, September 18)

Physical education (PE) teachers need to develop clear representaitons about physical activity (PA). In fact, they have to promote an active lifestyle among their pupils/students and it will not be ... [more ▼]

Physical education (PE) teachers need to develop clear representaitons about physical activity (PA). In fact, they have to promote an active lifestyle among their pupils/students and it will not be possible without developing an extended knowledge about physical activity. This presentation has been designed in order to make the PE teachers and their trainers that their representations about PA could be worse than they believe. Moreover, the interactive way of this presentation will provide an interesting example of an approach that could be used on the field. [less ▲]

Detailed reference viewed: 57 (3 ULg)
See detailNid de coucou. De quelques performances filmées dans l'espace public.
Hamers, Jérémy ULg

Conference (2015, September 18)

Detailed reference viewed: 24 (1 ULg)
Full Text
See detailInnovation in Veterinary Education. Innovative tools to teach pregnancy and parturition in the horse.
Hanzen, Christian ULg; Govaere, Jan

Conference (2015, September 18)

Detailed reference viewed: 87 (3 ULg)
Full Text
Peer Reviewed
See detailDietary mineral intakes of young Tibetan children living in areas endemic for Kashin-Beck disease: preliminary results of a cross-sectional survey
DERMIENCE, Michael ULg; Mathieu, Françoise; Li, Xiaowei et al

Conference (2015, September 18)

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy whose etiology remains unclear. Environmental factors are assumed to be involved, among which the selenium and iodine deficiency is ... [more ▼]

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy whose etiology remains unclear. Environmental factors are assumed to be involved, among which the selenium and iodine deficiency is frequently cited. The prevalence rate may be high in some rural areas of the Tibet Autonomous Region. The diet of the rural community is significantly different from the other communities (nomads and city-dwellers), who remains unaffected by KBD. Because their foods are mainly derived from local agriculture and artisanal production, their mineral composition may show significant discrepancies when compared with food composition data. The present survey aims at assessing the mineral dietary intakes of young Tibetan children living in rural areas endemic for the Kashin-Beck disease. A cross-sectional survey enrolling 250 children was carried out. The intakes were recorded for two days, on two different seasons, by the 24-hour food recall method. The minerals investigated were selected for their implication in bone metabolism and a specific food composition table was compiled from the China Food composition (book 1, 2nd edition), the USDA Food search for Windows (Version 1.0, Database version SR23), and a broad investigation on mineral composition of local and traditional Tibetan foods (Dermience et al., 2014). The calculation of daily intakes for the first season is now complete and some trends are emerging. Preliminary results suggest, inter alia, that the intakes of calcium are too low with unfavorable calcium to phosphorus ratio. On the contrary, sodium and manganese intakes are too high and could exceed tolerable upper levels. [less ▲]

Detailed reference viewed: 34 (6 ULg)
Full Text
Peer Reviewed
See detailSoluble biomarkers in OA: can they be used as indicator of HA re-injection?
Henrotin, Yves ULg

Conference (2015, September 18)

Detailed reference viewed: 16 (0 ULg)
See detailStability and Aging of Phase Change Materials : An Ab Initio Perspective
Raty, Jean-Yves ULg

Conference (2015, September 17)

Data recording with Phase Change Materials is a much studied topic as the writing/erasing characteristics, cyclability and downscaling properties of these materials allow for efficient data storage in ... [more ▼]

Data recording with Phase Change Materials is a much studied topic as the writing/erasing characteristics, cyclability and downscaling properties of these materials allow for efficient data storage in future generations of devices. Nevertheless, some aspects of phase change materials are limiting their performances and delaying their wider technological application. First, aging phenomena are common to all amorphous structures, but of special importance PCMs since it impedes the realization of multi-level memories. Different interpretations have been proposed, but we focus here on the structural relaxation of amorphous GeTe, chosen because it is the simplest system that is representative of the wider class of GST alloys, lying along the GeTe-Sb2Te3 composition line of the GeSbTe phase diagram. One difficulty encountered in the simulation of these amorphous systems is that the direct generation of an amorphous structure by quenching a liquid using Density Functional Theory (DFT) based Molecular Dynamics leads to one sample with a small number of atoms, and, hence of small number of atomic environments. Here we sample a large number of local atomic environments, corresponding to different bonding schemes, by chemically substituting different alloys, selected to favor different local atomic structures. This enables spanning a larger fraction of the configuration space relevant to aging. Our results support a model of the amorphous phase and its time evolution that involves an evolution of the local (chemical) order towards that of the crystal. On the other hand its electronic properties drift away from those of the crystal, driven by an increase of the Peierls-like distortion of the local environments in the amorphous, as compared to the crystal [1]. A second problem faced by PCMs is the fact that data recording is limited at high temperature due to the increased propensity to recrystallize. One approach to counter this is to stabilize the PCM using impurity atoms such as C or N. Using DFT and the analysis of the mechanical properties (constraints theory), we demonstrate how these impurity atoms modify the rigidity of the network, which is experimentally correlated with the activation energy for crystallization [2]. Finally, the crystal phase itself has been shown to have variable conductivities depending on the thermal history and annealing conditions. If this could be used profitably for multi-level recording, it also indicates that the crystal is undergoes some temporal evolution. Using DFT, we clarify the stability behavior of GST crystal and show that the metal-insulator transition is driven by the migration of intrinsic vacancies and an Anderson localization transition [3]. [1] J.Y Raty, W. Zhang, J. Luckas, C. Chen, R. Mazzarello, C. Bichara and M. Wuttig, Nat. Comm. (2015) [2] G. Ghezzi, J.Y. Raty, S. Maitrejean, A. Roule, E. Elkaim and F. Hippert, Applied Physics Letters, 99 (2011) 151906 [3] W. Zhang, A. Thiess, P. Zalden, R. Zeller, P. H. Dederichs, J-Y. Raty, M.Wuttig, S. Blügel et R. Mazzarello, Nature Materials 11 (2012) 952 [less ▲]

Detailed reference viewed: 91 (5 ULg)
Full Text
See detailUse of dual carbon-chlorine isotope analysis to identify degradation pathways of 1,1,1-trichloroethane in groundwater
Palau, Jordi; Jamin, Pierre ULg; Badin, Alice et al

Conference (2015, September 17)

The high susceptibility of chlorinated aliphatic hydrocarbons (CAHs) like 1,1,1-trichloroethane (1,1,1-TCA) to be transformed via different competing pathways (biotic and abiotic) complicates the ... [more ▼]

The high susceptibility of chlorinated aliphatic hydrocarbons (CAHs) like 1,1,1-trichloroethane (1,1,1-TCA) to be transformed via different competing pathways (biotic and abiotic) complicates the assessment of their fate in groundwater. This knowledge is necessary to evaluate contaminant degradation and potential formation of toxic intermediates. Identifying pathways is further complicated in sites contaminated by mixed CAHs because some degradation products of 1,1,1-TCA can be formed from different precursors. Here, identification of pathways based solely on substrate-product concentration relationships may lead to ambiguous interpretations. This study investigates, for the first time, dual C−Cl isotope fractionation as a means of identifying and assessing degradation pathways of 1,1,1-TCA in groundwater. Distinctly different dual isotope trends (L = Δδ13C/Δδ37Cl) were observed for 1,1,1-TCA transformation via oxidation with heat-activated persulfate (L = ∞), reduction with zerovalent iron (L = 1.5 ± 0.1), hydrolysis and dehydrohalogenation (HY/DH, L = 0.33 ± 0.04) in laboratory experiments, illustrating the potential of a dual isotope approach. This approach was evaluated in an aerobic aquifer impacted by 1,1,1-TCA and trichloroethylene (TCE) with concentrations of up to 20 mg/L and 3.4 mg/L, respectively. For 1,1,1-TCA, the dual isotope slope determined from field samples (L = 0.6 ± 0.2, r2 = 0.75) was close to the slope observed for HY/DH in the laboratory (L = 0.33 ± 0.04), indicating that HY/DH was the predominant degradation pathway of 1,1,1-TCA in the aquifer. The observed deviation could be explained by a minor contribution of additional degradation processes. This result, along with the little degradation of TCE determined from isotope measurements, confirmed that 1,1,1-TCA was the main source of the 1,1-dichlorethylene (1,1-DCE) detected in the aquifer with concentrations of up to 10 mg/L. This study demonstrates that a dual C-Cl isotope approach can strongly improve the qualitative and quantitative assessment of 1,1,1-TCA degradation processes in the field. [less ▲]

Detailed reference viewed: 48 (5 ULg)
Full Text
See detailThe system of sanctions for the illicit trade of nuclear goods
Colussi, Ilaria Anna ULg

Conference (2015, September 17)

In the area of nuclear non proliferation, the illicit trade of goods that could be used to create nuclear weapons cannot be neglected. Indeed, many States and non-States actors seeking nuclear weapons or ... [more ▼]

In the area of nuclear non proliferation, the illicit trade of goods that could be used to create nuclear weapons cannot be neglected. Indeed, many States and non-States actors seeking nuclear weapons or wanting to maintain existing nuclear weapons arsenals or capabilities look for obtaining, acquiring and transporting in their own States or locations dual-use technologies, items and materials. This entails a chain of “actors”: (a) the suppliers of goods, (b) a procurement organization, (c) a trade company for the procurement of goods, (d) intermediaries in transport, and (e) banks which could finance the operations. Therefore, a set of measures for preventing the illicit trade, and for sanctioning the occurred one, need to be defined. The paper aims at focusing on the “sanctioning” phase for illicit trade of dual-use nuclear items. It analyses the set of sanctions established at the international and European Union level, precisely the economic sanctions (e.g.: embargos), the financial one (i.e., freezing of assets), the visa and travel bans, and the limitations on transport of goods (i.e., export/import restrictions), by considering the legal texts adopted in the international and European Union framework, according to a comparative analysis. [less ▲]

Detailed reference viewed: 22 (0 ULg)
Full Text
See detailBien soigner l'arthrose: un enjeu capital pour notre société!
Henrotin, Yves ULg

Conference (2015, September 17)

Detailed reference viewed: 18 (0 ULg)
See detailAnalytical performance of a biomarker: what the clinician should know
CAVALIER, Etienne ULg

Conference (2015, September 17)

Detailed reference viewed: 13 (1 ULg)
See detailPriniples of Voice production
Finck, Camille ULg

Conference (2015, September 17)

Detailed reference viewed: 5 (0 ULg)
See detailworkshop:laryngoscopy hands on station
Finck, Camille ULg

Conference (2015, September 17)

training of a group of 20 endocrine surgeons to correctly perform a laryngeal examination in fibroscopy. Live examination of a patient suffering of laryngeal paralysis

Detailed reference viewed: 7 (0 ULg)
Full Text
See detailGeophysics for the quantification of water fluxes in the soil-plant system
Garré, Sarah ULg; Binley, Andrew

Conference (2015, September 17)

Detailed reference viewed: 29 (0 ULg)
See detailSurgir dans le paysage urbain. Analyse sociocritique du projet Selfiecity
Hagelstein, Maud ULg

Conference (2015, September 17)

Mon intérêt pour le selfie s’inscrit dans le cadre d’une réflexion plus large sur la photographie vernaculaire (ou commune – au double sens du terme), c’est-à-dire celle qui n’est ni professionnelle, ni ... [more ▼]

Mon intérêt pour le selfie s’inscrit dans le cadre d’une réflexion plus large sur la photographie vernaculaire (ou commune – au double sens du terme), c’est-à-dire celle qui n’est ni professionnelle, ni explicitement artistique. Le selfie est un outil visuel qui me semble pouvoir bien fonctionner avec la thématique de l’espace urbain : *le selfie travaille à la mise en scène d’un sujet dans un contexte au sein duquel il s’implique, le sujet ayant ceci de particulier qu’il se constitue à la fois comme observateur d’une scène, opérateur de l’image (= opérateur de la représentation de cette scène) et comme figurant de celle-ci (partie de son contenu). *En tant qu’il indique donc bien souvent une interaction entre un sujet et son environnement (spatial, social), le selfie pourrait être un bon indicateur du rapport de figuration, d’intégration, liant l’homme à son espace urbain (direct ou indirect). Il m’intéressera ici pour une seconde raison (dont les enjeux sont plus directement politiques) : puisque le dispositif est relativement nouveau, en développement, le selfie peut servir en quelque sorte de laboratoire dans lequel on pourrait observer la constitution de normes formelles. Autrement dit, la nouveauté de cette forme d’expression lui permet d’échapper relativement (et sans doute provisoirement) à l’inévitable institutionnalisation progressive que connaît généralement l’art urbain. [less ▲]

Detailed reference viewed: 53 (1 ULg)
Peer Reviewed
See detailVocabulaire liturgique et strates lexicales en indo-iranien ancien
Swennen, Philippe ULg

Conference (2015, September 16)

Detailed reference viewed: 14 (0 ULg)
See detailBuilding bridges (preliminary steps towards a new dictionary of Ancient Egyptian)
Winand, Jean ULg

Conference (2015, September 16)

Detailed reference viewed: 28 (1 ULg)
See detailQuestions à Nancy Fraser : Production et Reproduction du capital
Ghanbari Matin, Soheil ULg

Conference (2015, September 15)

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailEmpirical comparison of scoring rules at early stages of CAT
Magis, David ULg

Conference (2015, September 15)

Usual scoring rules in CATs include maximum likelihood (ML), weighted likelihood (WL) and Bayesian approaches. However, at early stages of adaptive testing, only a few item responses are available so the ... [more ▼]

Usual scoring rules in CATs include maximum likelihood (ML), weighted likelihood (WL) and Bayesian approaches. However, at early stages of adaptive testing, only a few item responses are available so the amount of information is very limited and in addition constant patterns (i.e. only correct or only incorrect responses) are often observed, yielding ML scoring intractable. Specific scoring rules (such as fixed- or variable stepsize adjustments) were developed for that purpose. However recent research highlighted that both Bayesian and WL scoring rules may provide finite values even with small sets of items. The purpose of this presentation is twofold: (a) to make a quick review of available scoring rules at early stages of CAT, and (b) to present empirical results from a simulation study that compares those scoring rules. More precisely, three scoring scenarios will be investigated: stepsize adjustment followed by ML, Bayes or WL followed by ML, and constant scoring rule throughout the CAT. These methods will be compared by means of simulated item banks and under various CAT scenarios for next item selection and stopping rules. Empirical results will be presented and practical guidelines for early stage scoring will be outlined. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
See detailTowards processes-based groundwater vulnerability assessments
Dassargues, Alain ULg; Popescu, Cristina; Brouyère, Serge ULg

Conference (2015, September 15)

Various groundwater vulnerability methods have recently been developed. Considering groundwater quality issues, the most common techniques are based on calculation of an index expressing the protective ... [more ▼]

Various groundwater vulnerability methods have recently been developed. Considering groundwater quality issues, the most common techniques are based on calculation of an index expressing the protective effect (i.e. in terms of solute contaminant transport) of underground formations overlying the groundwater resource (Gogu & Dassargues, 2000, Gogu et al., 2003)). However, there is a strong need for new methods giving more emphasis on the processes-based calculation of vulnerability indicators. As a first alternative, a method is proposed based on three factors describing a pollution event (Brouyère et al., 2001): (1) the transit time from the source to the target, (2) the duration of the contamination breakthrough at the target, (3) the ratio between the maximum concentration at the target to the released concentration at the contamination source. The method can feature the impact of surface runoff to preferential infiltration points. Practically, the assessment can then be based on the simulated breakthrough curves at the ‘target’ corresponding to Dirac-type solicitations (Popescu et al., 2008). Different vulnerability maps can be built according to the relative importance conventionally given to each of the three factors. This concept allows a clear distinction between conventional aspects and processes-based results in the building of a final vulnerability indicator. A second proposal consists in reframing the groundwater vulnerability assessment in a Pressure-State-Impact causal chain that is familiar to decision makers (Beaujean et al., 2013). The method is here based on the calculation of sensitivity coefficients for a user-defined groundwater state for which several physically-based indicators are proposed. The sensitivity coefficients reflect the easiness with which the groundwater state transmits pressures into impacts. They are converted to vulnerability, using the concept of ‘transgressing a given threshold’ (Luers et al., 2003). While the methodology is general and can be applied in quantity as quality issues, the choice of causal chains has to be made prior to the calculation. The vulnerability is also related to a damaged state and is related to the ‘distance’ between the current state and a given threshold. Here also, the method allows a clear distinction between conventional choices (threshold) and scientific work (Dassargues et al., 2009). [less ▲]

Detailed reference viewed: 43 (1 ULg)
Full Text
See detailSharing in neuroimaging: collecting with Brainmap, quantitatively analysing and sharing with ANIMA
Genon, Sarah ULg; Reid, Andrew; Eickhoff, Simon

Conference (2015, September 14)

Detailed reference viewed: 16 (1 ULg)
Full Text
See detailMethane distributions and sea-to-air fluxes in the South China Sea and the West Philippines Sea
Tseng, HC; Chen, C-T A; Borges, Alberto ULg et al

Conference (2015, September 14)

Detailed reference viewed: 13 (1 ULg)
Full Text
See detailCorporate Board Attributes and CAC: A Comparative Study of France, Germany and UK
Boussaid, Nabila ULg; Hamza, Taher; Sougné, Danielle ULg

Conference (2015, September 14)

This paper investigates the impact of corporate board of directors’ attributes on conditional accounting conservatim in the French, German and British contexts. Using pooled regression model over the ... [more ▼]

This paper investigates the impact of corporate board of directors’ attributes on conditional accounting conservatim in the French, German and British contexts. Using pooled regression model over the period 2009-2012, our findings report that the relationship between corporate board attributes and accounting conservatism is country dependent. First, regarding the board composition, we find that the effect of board size is positive for German firms, negative for French firms and insignificant for British firms. We also document a positive association between board independence and accounting conservatism for British firms. However, we find no evidence of a positive association between codetermination and earnings conservatism in German context. Second, female seats on board seem to increase conservative reporting in financial statement only for French firms. Lastly, board meeting frequency in French and British firms appears to increase accounting conservatism. As a robustness test, we use an alternative measure of accounting conservatism namely, time–series of earnings changes measure and confirm the previous results. Overall, our results reveal that corporate board affects the financial reporting quality. [less ▲]

Detailed reference viewed: 35 (2 ULg)
Full Text
See detail18FDG-PET/CT IMAGING IN SUSPECTED ACUTE RENAL ALLOGRAFT REJECTION
LOVINFOSSE, Pierre ULg; WEEKERS, Laurent ULg; BOVY, Christophe ULg et al

Conference (2015, September 13)

The diagnosis procedure for kidney transplant recipients (KTR) with suspected acute rejection (AR) relies on needle biopsy. Noninvasive tests to predict nonrejection would be preferable. AR is associated ... [more ▼]

The diagnosis procedure for kidney transplant recipients (KTR) with suspected acute rejection (AR) relies on needle biopsy. Noninvasive tests to predict nonrejection would be preferable. AR is associated with a recruitment of activated leukocytes into the transplant, which are characterized by a high metabolic activity and an increased uptake of glucose analog, Fluoro-deoxyglucose ( FDG). Thus, FDG-Positron emission tomography coupled with computed tomography (PET/CT) may help noninvasively distinguish nonrejection from AR. From January 2013 to February 2015, we prospectively performed 32 FDGPET/ CT in 31 adult KTR with suspected renal AR who underwent a biopsy. Biopsies were categorized as “normal”, “borderline”, “AR” or “others” according to Banff classification. PET/CT imaging was performed within 201 ± 18 minutes after i.v. administration of 3.2 ± 0.2 MBq/kg of FDG, before any modification of immunosuppression. The mean standard uptake values (SUV) of both upper and lower renal poles were measured, with no threshold activity. Biopsies were diagnosed as “normal”, “borderline”, “AR” or “others” in 8, 10, 8 and 6 (including 3 polyoma-BK nephropathies) cases. Mean SUV respectively reached 1.5 ± 0.2, 1.6 ± 0.3, 2.9 ± 0.8, 2.2 ± 1.2 in each category. Mean SUV of biopsy-proven AR was significantly higher than “normal” cases (p<0.01). No difference was found between “normal” vs. “borderline”, or between “AR” vs. “others” histopathology. Still, a positive correlation between mean SUV and acute composite (g+i+t+v+ptc) Banff score was found, with a coefficient of 0.70 (p<0.001). Sensitivity and specificity of FDG-PET/CT in detecting pathological biospies were respectively 92.3% and 36.8%, with a mean SUV threshold at 1.4. FDG-PET/CT imaging may help discriminate nonrejection, thereby avoiding unnecessary transplant biopsy in KTR with suspected AR. [less ▲]

Detailed reference viewed: 52 (8 ULg)
Full Text
Peer Reviewed
See detailMagnetic flux penetration in Nb superconducting films with lithographically defined micro-indentations
Silhanek, Alejandro ULg

Conference (2015, September 12)

We present a thorough investigation by magneto-optical imaging of the magnetic flux penetration in Nb thin films with lithographically defined micro-indentations. We demonstrate that discontinuity lines ... [more ▼]

We present a thorough investigation by magneto-optical imaging of the magnetic flux penetration in Nb thin films with lithographically defined micro-indentations. We demonstrate that discontinuity lines (d-lines) caused by the abrupt bending of current stream lines around the indentations, follow a nearly parabolic shape with concavity depending on the exact form and size of the indentation. We observe a progressive widening of the parabolic d-lines with increasing temperature whose origin may be linked to the weakening of the non-linearity of the current-voltage characteristics. These findings are corroborated and backed up by rigorous numerical simulations and analytical calculations. In addition, we show that the presence of nearby indentations and submicrometer random roughness of the sample border severely modifies the flux front topology. Unlike what has been predicted in the literature, indentations do not serve as nucleation spots for triggering flux avalanches, but instead help to release the flux pressure and avoid magnetothermal instabilities. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailTentativi di avvicinamento a Il figlio di Bakunìn (1991) di Sergio Atzeni (1952-1995)
Curreri, Luciano ULg

Conference (2015, September 11)

Detailed reference viewed: 50 (7 ULg)
Full Text
Peer Reviewed
See detailL'utilisation des insectes dans la pharmacopée de l'Égypte gréco-romaine
Marganne, Marie-Hélène ULg

Conference (2015, September 11)

The paper studies the use of insects in the pharmacopoeia of Greco-Roman Egypt according to papyrological evidence (IV/III centuries BC – VI/VII centuries AD), as well as Greek and Latin literary sources ... [more ▼]

The paper studies the use of insects in the pharmacopoeia of Greco-Roman Egypt according to papyrological evidence (IV/III centuries BC – VI/VII centuries AD), as well as Greek and Latin literary sources. The study examines the variety of species used, the medicinal properties attributed to them, and the diseases they were supposed to treat. [less ▲]

Detailed reference viewed: 35 (1 ULg)
See detailGreen synthesis of polyphosphoesters, a promising class of bioinspired degradable materials
Lecomte, Philippe ULg; Baeten, Evelien

Conference (2015, September 11)

Detailed reference viewed: 23 (4 ULg)
Peer Reviewed
See detailCe que l'image fait à l'histoire
Havelange, Carl ULg

Conference (2015, September 11)

Detailed reference viewed: 25 (1 ULg)
Peer Reviewed
See detailWill Big Data Deliver its Promised Productivity Growth?
Artige, Lionel ULg

Conference (2015, September 11)

Detailed reference viewed: 35 (0 ULg)
Full Text
See detailNumerical crashworthiness analysis of an offshore wind turbine monopile impacted by a ship
Bela, Andreea ULg

Conference (2015, September 11)

Detailed reference viewed: 18 (8 ULg)
Peer Reviewed
See detailPredator cues and risky habitats affect foraging activity in salamanders
Melotto, Andrea; Ficetola, Gentile Francesco; Denoël, Mathieu ULg et al

Conference (2015, September 11)

Detailed reference viewed: 16 (0 ULg)
See detailTable ronde : Qu'est-ce que l'image fait à l'histoire ?
Servais, Amandine ULg

Conference (2015, September 11)

L'AISV abordait, dans le cadre de son XIe congrès, la problématique : Theorein. Ce que les images font au savoir et inversement. Cette rencontre s'est clôturée par une table ronde - portant sur l'agence ... [more ▼]

L'AISV abordait, dans le cadre de son XIe congrès, la problématique : Theorein. Ce que les images font au savoir et inversement. Cette rencontre s'est clôturée par une table ronde - portant sur l'agence des images au sein de la discipline historique. Avec la participation de Ralph Dekoninck, Maud Hagelstein, Carl Havelange, Thierry Lenain et Amandine Servais. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
See detailLe sacrifice et la preprésentation des origines dans le monde indo-iranien ancien
Swennen, Philippe ULg

Conference (2015, September 11)

Detailed reference viewed: 10 (1 ULg)
Full Text
See detailChallenges for Scale-Up of Batch Phase Separation
Pfennig, Andreas ULg; Becker, Karsten; Bach, S. et al

Conference (2015, September 10)

Bi-phasic phase separations in batch processes often are operations which influence cycle times and production capacity. A realistic assessment of phase separation time for technical scale is important ... [more ▼]

Bi-phasic phase separations in batch processes often are operations which influence cycle times and production capacity. A realistic assessment of phase separation time for technical scale is important with respect to defining vessel sizes, process step-time planning and an optimized adaption to further process steps. This requires a rating of batch mixing & phase-separation at an early step of chemical-process development in laboratory and a robust scale-up to the technical scale. Currently available methods for design and optimization of such batch phaseseparations show gaps in knowledge and in transfer from laboratory to technical scale. Up to now it is not possible to trustfully predict mean drop diameter or dropsize distribution for technical relevant bi-phasic systems in technical scale based on laboratory tests. These are one of the key inputs to describe phase separation behavior, i.e. sedimentation and coalescence. The prediction of drop-size distribution after scale-up is important, since a remaining turbidity is significantly influenced by these. In addition systems with higher viscosity show wider drop-size distributions and tendency of turbidity will increase. The specific industrial demand for a safe and validated scale-up method will be discussed. Aspects are an integral general scale-up method for batch mixing and phase separation, starting with standardized characterization of mixing and phaseseparation behavior in lab and development of a scale-up method in order to evaluate relevant aspects as equipment and mixing device, energy input, mixing time, phase separation time, height of dispersion etc. For modelling the performance of a batch settling accounting for polydisperse dropsize spectra, the model of Henschke has been chosen as starting point, which accounts for different average drop sizes. The Henschke model has been extended as to include the sedimentation of drops with polydisperse drop-size distribution according to the ReDrop approach (representative drops) by modelling an ensemble of individual drops as they sediment and reach the close-packed layer. In principle coalescence of the sedimenting droplets could be accounted for in this approach, but this has been neglected in this first step. The Henschke model already accounts for the time- and height-dependent average drop sizes in the close-packed layer. This has been extended as to allow taking the different drop sizes into account of those drops that are arriving at the close-packed layer over time. The coalescence in the close-packed layer is described with the approach used already by Henschke, which has been validated in principle by Kopriwa. The results show that the polydispersity can well be described by this approach (see Fig. 1). Especially – as is to be expected – the major phase separation occurs relatively quickly leaving behind fine droplets in the continuous phase. Since this remaining turbidity has a relatively low holdup, the sedimentation of the fine dispersion occurs essentially with the sedimentation velocity of droplets in infinitely extended medium. As a consequence the remaining turbidity as function of settling time can be estimated with relatively good accuracy from the fraction of the fine droplets in the original dispersion and their individual sedimentation velocity. It can also be seen that the close-packed layer disappears after a certain settling time and after that the rate of the arriving droplets is smaller than the time for their coalescence. The open questions remaining will finally be addressed, namely the prediction of the drop-size distribution after the mixing step, the detailed drop behavior within the close packed layer as well as the influence of large-scale fluid dynamics within the settler. [less ▲]

Detailed reference viewed: 54 (3 ULg)
Full Text
See detailOsteopontin as a new target in glioblastoma progression and resistance to radiotherapy
Henry, Aurélie ULg; Bellahcene, Akeila ULg; Castronovo, Vincenzo ULg et al

Conference (2015, September 10)

Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These treatments ... [more ▼]

Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These treatments include maximal surgical resection, radiotherapy and concomitant or adjuvant chemotherapy with Temozolomide (TMZ). However, the prognosis of adult patients with GBM remains poor and the survival outcome after treatment does not exceed 15 months. Glioblastoma-composing cells have developed many strategies to counteract these current therapies. Among the wide hallmarks acquired to survive, osteopontin (OPN) ranks correlates with lower overall and disease-free/relapse-free survival in all tumors combined, as well in brain cancer. OPN expression is largely considered as a molecular cancer marker associated with poor prognosis for patients with cancer. Our preliminary works (Lamour V and Henry A, IJC 2015) have demonstrated the role of OPN in the tumorigenicity of glioblastoma cells and its importance in the maintenance of the stem charachters. Within the continuance of this work, our recent studies focused on the potential role of OPN in the resistance of glioblastoma cells to radiotherapy and its implication in the initiation of Double Strand Breaks (DSBs) repair mechanism. In this context, U251-MG and U87-MG cells were used to assess the role of OPN in the initiation of the DSBs repair mechanism after an exposure to gamma-irradiation (γ–IR). The transient transfection of both cell lines with siRNA directed against OPN shown a lower induction of γ–H2AX compared to control (irrelevant siRNA). The survival of U251-OPN depleted cells was also affected after an exposure to γ–IR (based on clonogenic assays). However, the sole depletion of OPN in U87 cells affected their survival (independently of the γ–IR). To prove that the secreted form of OPN is necessary to survive after γ–IR, conditionned medium of U87-shSCR clones (rich in OPN) was used to treat U87shOPN clones before an exposure to γ–IR. By immunofluorescence, we observed that the γ–H2AX staining was higher in U87 shOPN clones than when treated with their own conditionned medium (poor in OPN). Currently, we are investigating the in vivo implication of OPN in the initiation of DSBs repair mechanism after an exposure of mice to γ–IR (whole brain exposure). For this purpose, IPTG-inducible U87 shRNA clones (SCR and OPN) have been generated and validated for an orthotopic xenograft model in NOD-SCID mice. The survival after a radiotherapy of 10 Gy (2Gy per day for 5 days) will be assessed in OPN-positive and –negative tumor-bearing mice. Taken together, these datas suggest that OPN could represent an important pronostic factor for patient response to radiotherapy in the context of GBM. [less ▲]

Detailed reference viewed: 137 (29 ULg)
See detailDéception et incertitude en démocratie
Jamin, Jérôme ULg

Conference (2015, September 10)

Detailed reference viewed: 16 (1 ULg)
Peer Reviewed
See detailRegards croisés sur la représentation énonciative des genres dans les BD féminines contemporaines : le cas d’une BD africaine et d’une BD occidentale
Goufo Zemmo, ULg

Conference (2015, September 10)

La problématique des «Gender Studies » fait l’objet de multiples questionnements dans l’ensemble des études depuis quelques années. La question des genres a, d’une manière ou d’une autre, fait le tour de ... [more ▼]

La problématique des «Gender Studies » fait l’objet de multiples questionnements dans l’ensemble des études depuis quelques années. La question des genres a, d’une manière ou d’une autre, fait le tour de tous les arts. La bande dessinée (BD), elle aussi, n’a pas échappé à ce problème. En effet, si les BD ont longtemps été créées par les hommes (Hergé, Goscinny, Uderzo …) les femmes, de plus en plus aussi, ont investi ce médium. On assiste aujourd’hui à un véritable regain de créations dites « féminines » sur tous les continents ; bien entendu, le continent africain n’en fait pas exception. En effet, la question des genres y est encore plus aigüe, d’autant plus que, la femme y a toujours été marginalisée. Ce qui nous intéresse ici ce n’est pas de comprendre comment la BD donne à réfléchir sur les genres en en donnant des caractéristiques ou des outils de compréhension de la société moderne, mais de montrer comment cette dernière devient militante dès lors qu’elle réclame la parité au sein même des représentations. En d’autres termes, comment les bédéistes féminines au travers de ce médium interrogent-elles les normes de genres par l’image et mettent en place leur subversion ? Nous sommes tentés de répondre que tout est mis en jeu pour que les rôles actantiels les plus significatifs soient portés par des acteurs féminins. De plus, le dessin en lui-même, les cadrages et différentes perspectives ne sont plus que des instruments au service du dessinateur. Leur rôle servant à la réorganisation cognitive des informations présentes dans les mémoires collectives. Nous prendrons appui sur la sémiotique de l’énonciation, dans une approche greimassienne, qui part du registre narratif pour comprendre les procédures sous-jacentes aux démarches de notre pensée à travers le registre logico-sémantique. Nous nous appuierons sur deux bédéistes, issues d’un univers culturel différent, pour comprendre comment l’une à travers la disposition spatiale des personnages (masculin/ féminin) sur la vignette et l’autre par la répartition des rôles actantiels créent un flou énonciatif visant à réorganiser les clivages et redonner aux femmes une place qui leurs aurait été déniée depuis bien longtemps. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailNumerical simulations on embedded solids : integration of CAD and eXtended Finite Element Analysis
Duboeuf, Frédéric ULg; Béchet, Eric ULg

Conference (2015, September 10)

The aim of this communication is to propose a procedure in order to dissociate the geometric description of the field’s approximation within the extended finite element method (X-FEM) and with non ... [more ▼]

The aim of this communication is to propose a procedure in order to dissociate the geometric description of the field’s approximation within the extended finite element method (X-FEM) and with non-matching meshes. Implicit and explicit approaches are combined in order to represent with accuracy all the CAD entities regardless of their dimension. The choice of appropriate tools such as Level Sets technique allows to describe evolving interfaces with great flexibility. The design of a dedicated P1 functional space is achieved by decimating the traces of standard finite element (FE) shape functions, thanks to a new algorithm, especially when the problem domain is embedded in a space of a higher dimension. An analysis of the approximation properties of the P1 FE trace spaces on hyper-surfaces is available in the literature and applied for solving PDEs on closed surfaces without boundary. Dirichlet boundary conditions are applied using a convenient choice of stable Lagrange multiplier space, according to a new generalized algorithm. That extends the existing solutions to every combination of the space domain and boundary dimensions. In terms of solvers, the introduction of double Lagrange multipliers can be used to recover the positive definiteness of the bilinear form. This approach allows to treat any embedding, i.e. 1, 2, or 3D problems embedded in 2 or 3D background meshes. The possibility of applying the methodology to beams is investigated, with a potential application to through-thickness reinforced composites in a mixed-dimensional modelling framework. [less ▲]

Detailed reference viewed: 67 (25 ULg)
Peer Reviewed
See detailNewts skip aquatic life and forego reproduction in response to alien fish introduction
Winandy, Laurane ULg; Darnet, Elodie; Denoël, Mathieu ULg

Conference (2015, September 10)

Detailed reference viewed: 17 (1 ULg)
Peer Reviewed
See detailReevaluating IUCN Red List assesment on European amphibians
Crnobrnja-Isailović, Jelka; Cogalniceanu, Dan; Denoël, Mathieu ULg et al

Conference (2015, September 09)

Detailed reference viewed: 34 (0 ULg)
See detailPractical training session on virus discovery from High Throughput Sequencing data
Massart, Sébastien ULg

Conference (2015, September 09)

Detailed reference viewed: 11 (0 ULg)
See detailUn musée du Moyen Age à Namur
George, Philippe ULg

Conference (2015, September 09)

Detailed reference viewed: 19 (0 ULg)
Peer Reviewed
See detailEarly medieval glass tiles from Saint-Sauveur (Burgundy, France)
Van Wersch, Line ULg; Mathis, François ULg; Bonnin, Myrtho et al

Conference (2015, September 09)

Detailed reference viewed: 11 (0 ULg)
Peer Reviewed
See detailWhat do they mean? Listening to babies communicating in the daily setting in ECEC service
Pirard, Florence ULg; Legrand, Anne; Michel, Aurore ULg

Conference (2015, September 09)

The main aim of the study was to gain understanding of how babies communicate in ECEC services. Previous literature indicates that babies can interact and communicate precociously, not only with adults ... [more ▼]

The main aim of the study was to gain understanding of how babies communicate in ECEC services. Previous literature indicates that babies can interact and communicate precociously, not only with adults (Stern, 2005; Threvarten, 2011), but also with other children (Tomasello et al., 2005). The ECEC service can be considered as a setting where interaction and communication between peers can be sustained by practitioners who observe them, document what happens, analyse together the educational condition to guarantee and regulate their action (Stambak et al., 1983). The study involved qualitative and action research initiated by Cresas and IEDPE (self-regulating participatory assessment, Ballion et al., 1988), combined with an analysis of activity approach focused on contextualised process. An action researcher has gathered practitioners, trainers and researchers from France, Spain, Croatia, Italy and Belgium to analyse educational daily practice in ECEC services and their effect on communication between peers. Videos have been used to document and analyse the practice (EADAP, 2011). The ethical considerations taken in this study involved collaborative perspectives that give an active place to all participants (researchers, trainers, practitioners? parents and children). Informed consent and authorization for using video in the research are guaranteed. Participants identify and document communication processes between very young children observed in natural setting (ECEC services). These processes are characterised by several aspects: duration, emotional expression and meaningful linking of observed behaviours between babies. A shared meaning from the video documentation can be co-constructed like some narrative stories. Participants consider the activity of babies as meaningful stories that they should understand and sustain with interest. We discuss implications for professionalisation of the workforce (initial training and professional development). [less ▲]

Detailed reference viewed: 27 (5 ULg)
Peer Reviewed
See detailStudy of the impact of school average ability on career expectations
Dupont, Virginie ULg

Conference (2015, September 09)

Detailed reference viewed: 23 (2 ULg)
Full Text
See detailSocial Enterprise Models in a worldwide Comparative Perspective
Defourny, Jacques ULg

Conference (2015, September 08)

Detailed reference viewed: 31 (1 ULg)
Full Text
Peer Reviewed
See detailEthylene polymerization mediated by nickel(II) covalently anchored to silica xerogels
Lambert, Stéphanie ULg; Sacco, Luigi

Conference (2015, September 08)

Heterogeneous catalysis is generally widely preferred for industrial applications thanks to the well-known advantages of easier product-catalyst separation and recovery of the catalyst process and, often ... [more ▼]

Heterogeneous catalysis is generally widely preferred for industrial applications thanks to the well-known advantages of easier product-catalyst separation and recovery of the catalyst process and, often, to the enhanced stability of the catalyst. But in terms of selectivity, homogeneous catalysis usually provides better results. From this point of view, the grafting of homogeneous catalysts onto a solid support seems the ideal combination in order to achieve the advantages of both heterogeneous and homogeneous catalysis, allowing the developing of more environmentally friendly and economical processes with potential application in the industry. Further, to covalently link a homogeneous onto silica (a support which is thermally, chemically and mechanically resistant, with a well defined structure) is the best way to limit metal leaching and sintering. Nitrogen-based ligands containing one of several Schiff bases have been reported to form active catalysts with “late-metal” (such as Fe, Pd, Ni,…) for the ethylene polymerization [1]. Moreover, substituted pyrazole-based organometallic complexes gave also promising results in this field. These facts let us suggest that the pyrazolylpyridine derivatives bearing a tethered trimethoxysilylated group synthesized in a previous work [2] are potentially good candidate to prepare hybrid catalyst (i.e. soluble organometallic complexes covalently bonded onto an insoluble support, in this case silica) with Ni-II, Fe-II or Pd-II for ethylene polymerization. [less ▲]

Detailed reference viewed: 23 (2 ULg)
See detailPremières notes pour l'ethnographie d'un projet européen en situation embarquée
Thoreau, François ULg

Conference (2015, September 08)

Detailed reference viewed: 17 (0 ULg)
Peer Reviewed
See detailComparison of 3 diffractive IOLs: one monofocal (achromatic), one bifocal and one trifocal lens implant
Gatinel, Damien; Loicq, Jerôme ULg; Pagnoule, Christophe et al

Conference (2015, September 08)

Purpose: To describe the optical performance of 3 types (monofocal, bifocal and trifocal) of diffractive hydrophobic intraocular lenses (IOLs). Setting: Fondation Rothschild, Paris, France Methods: An ... [more ▼]

Purpose: To describe the optical performance of 3 types (monofocal, bifocal and trifocal) of diffractive hydrophobic intraocular lenses (IOLs). Setting: Fondation Rothschild, Paris, France Methods: An achromatic monofocal, a bifocal and trifocal diffractive IOLs were measured with an optical bench, designed to measure Modulation transfer function (MTF) and point spread function (PSF) of diffractive intraocular lenses. The measurements were performed at 3 wavelengths (480 nm, 546 nm and 650 nm), using an aberration free cornea and an aspherical artificial cornea generating a +0.28 µm of positive spherical aberration (ISO 11979-2 guideline). The through-focus MTF was recorded with the 3 IOLs for various pupil apertures. The evaluation of the magnitude of the halos was performed from PSF measurement obtained at each focal spot location. Results: The monofocal and the two bifocal IOLs were presenting 2 peaks on the through-focus MTF in the green: for intermediate vision (at 1.75D) for the monofocal achromatic lens, and for far and for near vision( at +4D) for the bifocal IOL of the same material. Three peaks were recorded with the trifocal IOL at any wavelength. The achromatic monofocal was monofocal for far in the red and monofocal for near in the blue. The amount of energy allocated to each focal point was not very different for the three IOLs except for smaller apertures where the distance vision with the trifocal IOL had a significant lower peak than the two other IOLs. The amount of halos were comparable between lenses. Conclusions: The diffractive and refractive optics generated opposite chromatic aberration. A achromatic diffractive IOL behaves like a bifocal IOL with an intermediate addition The bifocal and trifocal IOL induce similar chromatic effects for the near (bifocal, trifocal) and intermediate (trifocal) foci. The tested diffractive patterns wee not efficient to correct the chromatic aberration at the distance foci for all tested IOLs. [less ▲]

Detailed reference viewed: 36 (1 ULg)
Peer Reviewed
See detailIconic virtues of diagrams. Peirce and ampliative reasoning
Leclercq, Bruno ULg

Conference (2015, September 08)

In his Critic of pure reason, Immanuel Kant notoriously claimed that, being grounded on the forms of sense intuition, arithmetical and geometrical propositions are both synthetic (i.e. informative) and a ... [more ▼]

In his Critic of pure reason, Immanuel Kant notoriously claimed that, being grounded on the forms of sense intuition, arithmetical and geometrical propositions are both synthetic (i.e. informative) and a priori. Bernard Bolzano, followed in this by the logicist movement (from Gottlob Frege to Rudolf Carnap), answered that the generality and necessity of mathematical propositions and proofs can only be grounded on conceptual analysis. Even though, just like Frege, he is one of the fathers of formal logic, Charles Sanders Peirce provides some semiotic reasons to think that Kant was right: diagrams do convey general meanings and provide some knowledge which is necessary yet non-trivial. Unlike logical analysis, visual presentation of concepts in schemas or diagrams helps to explore concepts by stressing some of their “side” features in such a way that new knowledge is gained: « diagrams evolve what was involved » (CP4/86). This is why, according to Kant’s notion of intuitive construction, mathematical inferences are not merely deductive but are inventive and ampliative. My talk aims at identifying some iconic virtues of diagrams which, according to Peirce, explain their epistemic productivity. A first one lies in the “formal” nature of icons, which allows them to express syntactic relations between descriptive (symbols) and demonstrative (indices) components of structured information. On this respect, even algebraic and ideographic expressions are icons exhibiting a general form – a “rheme” – in which places for indices are filled with variables “x” and “y” meaning “any individual”. For this reason, even though they are singular, diagrams are “abstractions” in the sense that they represent relations rather than their terms. Only with this in prospect can a second, and more studied, feature of diagrams matter, namely their two-dimensionality, which helps to exhibit complex relations that cannot be seen on linear linguistic expressions. Finally, a third feature of diagrams lies in their imaginary rather than referential character. Icons connote without denoting, and therefore they can be informational without this information being limited to singular individuals. Furthermore, this non referential character of icons is what makes them open to virtual exploratory manipulations that allow to consider and investigate possibilities which in turn inform us on not obvious properties of the presently visible configuration. [less ▲]

Detailed reference viewed: 45 (0 ULg)
Peer Reviewed
See detailProperties of a new hydrophobic diffractive trifocal intraocular lens: linear chromatic aberrations (LCA) by optical simulation and optical bench testing
Loicq, Jerôme ULg; Gatinel, Damien

Conference (2015, September 08)

Purpose: Impact of the IOL raw material Abbe number on diffractive trifocal optical outcomes in terms of light energy partition between the three foci, modulation transfer function (MTF) and linear ... [more ▼]

Purpose: Impact of the IOL raw material Abbe number on diffractive trifocal optical outcomes in terms of light energy partition between the three foci, modulation transfer function (MTF) and linear chromatic aberration (LCA). Setting: Space Center Liège (Centre Spatial de Liège), University of Liège, Liège, Belgium Methods: The difference between hydrophilic and hydrophobic materials doesn't rely on biocompatibility only, but also influence some optical properties. In order to highlight the impact of the raw material associated to Diffractive-Trifocal-IOLs, we compare certain optical properties of two Diffractive-Trifocal-IOLs associated to Physiol's Trifocal-technology and made of 26% hydrophilic and hydrophobic GF raw material. The Abbe number of the two IOL materials was measured with a refractometer. The through focus MTF curves at 3 wavelengths (480, 546 and 650 nm) and different apertures were generated by simulation in an Arizona eye model and compared with results on a PMTF optical bench. Results: The through focus MTF curves at the three wavelengths shows that the diffracted light for the near vision (+3.5 D) by the trifocal optic generates chromatic aberrations of opposite sign with respect to the refracted light assigned to the Far vision. The diffracted light at the origin of the Intermediate vision (+1.75 D) does not show significant amount of LCA and can be considered as a chromatic aberration free focus. Results are similar for the two lens materials. Conclusions: Diffractive Trifocal IOLs show chromatic aberrations whose sign and amplitude depend on the add-power of the different foci (far, near or intermediate), but is basically independent of the nature of the type of raw material, hydrophilic or hydrophobic. [less ▲]

Detailed reference viewed: 28 (3 ULg)
See detailThe 4m International Liquid Mirror Telescope
Surdej, Jean ULg

Conference (2015, September 07)

The International Liquid Mirror Telescope (ILMT) consists of a 4-m diameter zenith telescope with a liquid mirror characterized by a f/2 focal ratio. It is a collaborative project between Belgium, Canada ... [more ▼]

The International Liquid Mirror Telescope (ILMT) consists of a 4-m diameter zenith telescope with a liquid mirror characterized by a f/2 focal ratio. It is a collaborative project between Belgium, Canada, India and Poland. The participating institutions are: Institute of Astrophysics and Geophysics of the Liege University (IAGL), the Royal Observatory of Belgium (ROB), six Canadian universities (British Columbia, Laval, Montreal, Toronto, Victoria and York), the Aryabatta Research Institute of Observational Sciences (ARIES, Nainital, India) and the Observatory of Poznan (UAM, Poland). This telescope is being installed at the Devasthal observatory, India (Longitude 79° 41' 04'' E, +29° 21' 40'' N, altitude 2450m), in the central Himalayas. First light should happen in early 2016. It will image every night a strip of sky having an approximate width of 27' in declination using a 4096 x 4096 pixel CCD detector that will work in the time delay integration (TDI) mode. The ILMT will thus perform a deep survey of a long and narrow strip of sky by looking at stars, galaxies, AGN, quasars, asteroids, space debris, ... crossing its field of view. It will observe in the i', r', g' SDSS spectral bands. This survey will thus be mainly dedicated to photometric and astrometric variability studies of faint objects. Among the main scientific goals, let us mention the detection and follow up of a few tens of multiply imaged quasars produced by gravitational lensing, hundreds of supernovae every year, detection of nearby brown dwarfs, white dwarfs and other faint stars based upon their trigonometric parallax and/or proper motion measurements, photometric variability studies of thousands of quasars and millions of stars as well as space debris detection at dusk and/or at dawn. Right now, numerous data sets have already been obtained of the ILMT strip of sky with smaller telescopes in the TDI mode. These will be used to carry out preliminary scientific projects and calibration of the ILMT data. A pipeline and database are presently in construction at the Poznan Observatory. Some videos and recent photographs will illustrate the present status of the ILMT project. [less ▲]

Detailed reference viewed: 27 (4 ULg)
Full Text
Peer Reviewed
See detailBrazil-EU Relations: Strategic Partner or Competitors?
Santander, Sébastian ULg

Conference (2015, September 07)

Detailed reference viewed: 34 (5 ULg)
See detailImmunoglobulin E enhances host resistance to venoms.
Marichal, Thomas ULg

Conference (2015, September 07)

Detailed reference viewed: 11 (1 ULg)
See detailDiasporic Experience and Music in Caryl Phillips’s Crossing the River
Mascoli, Giulia ULg

Conference (2015, September 07)

This paper deals with Caryl Phillips who has incessantly represented diasporic experience in his work where he evokes complex identities at the crossroads between Africa, the Caribbean and Europe. My ... [more ▼]

This paper deals with Caryl Phillips who has incessantly represented diasporic experience in his work where he evokes complex identities at the crossroads between Africa, the Caribbean and Europe. My proposal is to concentrate on Phillips’s novel Crossing the River (1993) which extensively explores the theme of the African diaspora and which, interestingly, has also been described as his most jazzy text. This narrative not only addresses diasporic themes, such as uprootings and lost origins, but very much like jazz -- which is for Brathwaite “a cry from the heart of the hurt man” (277) – it gives a voice to the victims of history, to shattered individuals in pain whose tragic fate is viewed at once as personal and collective. Benítez-Rojo draws attention to the importance of rhythm in this text, but he only provides a limited analysis with no specific examples of how this significant feature of the work is achieved or the purposes it serves. In this paper I will try to demonstrate that Phillips’s thematic and formal use of music, including the references to classic themes of the African American musical tradition or the recurrent and creative use of repetitions, has a performative role and reenacts the duty of remembering inherent in the diasporic experience. [less ▲]

Detailed reference viewed: 26 (3 ULg)
See detailLa perte comme identité : le cas des familles post-séparation et post-divorce.
D'Amore, Salvatore ULg

Conference (2015, September 07)

Detailed reference viewed: 27 (1 ULg)
See detailA Stylistic Analysis of Caryl Phillips's "Made in Wales"
Tunca, Daria ULg

Conference (2015, September 07)

Detailed reference viewed: 73 (4 ULg)
Full Text
Peer Reviewed
See detailCitizens abroad and Regional Elections: A diffusionist Perspective
Lafleur, Jean-Michel ULg; Arrighi, Jean-Thomas

Conference (2015, September 06)

In this paper we shift the focus away from the state to the regional demos with the aim to introduce the notion of scale in the study of external voting. It is divided into three parts. Following a ... [more ▼]

In this paper we shift the focus away from the state to the regional demos with the aim to introduce the notion of scale in the study of external voting. It is divided into three parts. Following a preliminary discussion on the external franchise from a sub-state perspective, we proceed with a comparative overview of the rules of acquisition and loss of the franchise in regional elections and show that the extension of the franchise to ‘regional expatriates’ is a relatively exceptional practice. We then identify factors that in our view are key to understand the absence of a vertical diffusion of the external franchise to lower levels of government, in sharp contrast with its rapid horizontal diffusion at the state level. The second part examines the debates surrounding the inclusion and exclusion of the franchise in three cases of protracted nationalist mobilization that translated into far reaching territorial autonomy: Catalonia, Scotland and Flanders. The third and final section contrasts the similarities and differences that can be found between our three cases and reflects upon the lessons that can be drawn from them. [less ▲]

Detailed reference viewed: 35 (0 ULg)
Full Text
Peer Reviewed
See detailBinge Drinking at young age
Gavray, Claire ULg

Conference (2015, September 05)

discussion théorique et méthodologique sur le concept et la mesure du binge drinking. Présentation des facteurs liés à cette pratique chez les adolescents filles et garçons. Analyse des résultats à la ... [more ▼]

discussion théorique et méthodologique sur le concept et la mesure du binge drinking. Présentation des facteurs liés à cette pratique chez les adolescents filles et garçons. Analyse des résultats à la lumière des opportunités historiques sexuées en évolution.données ISRD3-Belgique [less ▲]

Detailed reference viewed: 53 (20 ULg)
See detailAge-related modulations in cognitive functions and its cerebral underpinnings
Collette, Fabienne ULg

Conference (2015, September 04)

Detailed reference viewed: 16 (1 ULg)
Full Text
See detailFrom Aleph to Alma: Fulfillment, feel it fully
Van Ruymbeke, Muriel ULg; Lhoest, Rémy ULg; Thirion, Paul ULg

Conference (2015, September 04)

If it is well prepared, migrating from Aleph to Alma brings users a lot of advantages. To reach the go live day with as less worries as possible, ULg Library's preparation consisted in two things: a deep ... [more ▼]

If it is well prepared, migrating from Aleph to Alma brings users a lot of advantages. To reach the go live day with as less worries as possible, ULg Library's preparation consisted in two things: a deep understanding of Alma new concepts and a simplification of our physical fulfillment policy. This presentation, based on our experience, will aim at describing the main differences between Aleph and Alma regarding fulfillment concepts and their significant consequences on implementation and migration jobs. On a fulfillment point of view, what distinguishes Aleph from Alma is that, in Aleph, the circulation policy is based on item status. On the contrary in Alma it is based on the location, and its traffic rules built by a set of terms of uses (TOU). Numerous other idioms complete the Alma toolkit and allow physical item’s fulfillment customizing. But to really enjoy the new possibilities given by Alma, it is important to fully feel the necessary changes… at the very beginning ! [less ▲]

Detailed reference viewed: 90 (6 ULg)
Full Text
See detailMagnetic shielding properties of tubular bulk superconductors subjected to stray magnetic fields
Hogan, Kevin ULg; Fagnard, Jean-François ULg; Wera, Laurent ULg et al

Conference (2015, September 04)

Superconducting materials act as efficient magnetic shields thanks to their intrinsic magnetic properties. The vast majority of studies on superconducting shields has been conducted in homogeneous ... [more ▼]

Superconducting materials act as efficient magnetic shields thanks to their intrinsic magnetic properties. The vast majority of studies on superconducting shields has been conducted in homogeneous magnetic field configurations. Only few works have been done concerning inhomogeneous magnetic field configurations while those are representative of practical situations. Moreover, those configurations are non-trivial given the magnetic hysteretic behaviour of type-II superconductors. In the present work, we aim at investigating and understanding the magnetic response of a superconducting hollow cylinder made of Bi-2223 subjected to the magnetic stray field of various magnetic sources. Thanks to a bespoke 3D mapping system and a three-axis Hall probe, we measure the magnetic flux density distribution in the vicinity of the cylinder when the latter is subjected to those stray fields. All experiments are carried out in liquid nitrogen. Our experimental data allow us to apprehend the magnetic field penetration inside the superconductor in inhomogeneous field configurations and to compare those to results obtained with homogeneous fields. Then we compare our results to a finite element model of an infinite tube subjected to an inhomogeneous magnetic field in order to gather information on the magnetic field penetration and the current density distribution inside the superconductor. [less ▲]

Detailed reference viewed: 44 (11 ULg)
See detailWildflowers sown at field margins have positive and negative effects on pests and parasitoids
Hatt, Séverin ULg; Uyttenbroeck, Roel ULg; Chevalier Mendes Lopes, Thomas ULg et al

Conference (2015, September 03)

Wildflower strips are sown at field margins throughout Europe to support insect conservation in agricultural areas. Among other insects, parasitoids may favor a biological regulation of pests. On an ... [more ▼]

Wildflower strips are sown at field margins throughout Europe to support insect conservation in agricultural areas. Among other insects, parasitoids may favor a biological regulation of pests. On an experimental field of the research platform AgricultureIsLife in Gembloux (University of Liège, Belgium), three replications of five wildflower seed mixtures were sown in strips adjacent to crops in spring 2013. Insect pests and their parasitoids were pan-trapped in spring 2014 in both wildflower strips and oilseed rape crops and identified at the species level. Flower species and cover were monitored in the strips using 1 m² quadrats, before mowing. Meligethes spp. were found abundantly in crops when oilseed rape was blooming. Meligethes’ parasitoids occurred later and their abundance was positively correlated with that of Meligethes in the flower strips. At the crop ripening stage, weevils Ceutorhynchus spp. occurred and were followed by an increase in abundance of their parasitoids in both crops and flowers. Positive as well as negative correlations were found between the abundance of these pests, their parasitoids and different flower species blooming at this time. The link between these results with flower species’ functional traits will be discussed. [less ▲]

Detailed reference viewed: 47 (14 ULg)