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See detailTeaching and Training TA
Delvenne, Pierre ULg; Rosskamp, Benedikt ULg; Bütschi, Danielle et al

Poster (2015, February 26)

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See detailLes peptides natriurétiques: le point de vue du biologiste
LE GOFF, Caroline ULg

Conference (2015, February 26)

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See detailPropagation of uncertainties using probabilistic multi-scale models
Lucas, Vincent ULg; Wu, Ling ULg; Paquay, Stéphane et al

Conference (2015, February 25)

When applying a multiscale approach, the material behavior at the macro-scale can be obtained from an homogenization scheme. To this end, at each integration-point of the macro-structure, the macrostress ... [more ▼]

When applying a multiscale approach, the material behavior at the macro-scale can be obtained from an homogenization scheme. To this end, at each integration-point of the macro-structure, the macrostress tensor is related to the macro-strain tensor through the resolution of a micro-scale boundary value problem. At the micro-level, the macro-point is viewed as the center of a Representative Volume Element (RVE). However, to be representative, the micro-volume-element should have a size much bigger than the micro-structure size. When considering structures of reduced sizes, such as micro-electro-mechanical systems (MEMS), as the size of the devices is only one or two orders of magnitude higher than the size of their microstructure, i.e. their grain size, the structural properties exhibit a scatter at the macro-scale. The representativity of the micro-scale volume element is lost and Statistical Volume Elements (SVE) should be considered in order to account for the micro-structural uncertainties. These uncertainties should then be propagated to the macro-scale in order to predict the device properties in a probabilistic way. In this work we propose a non-deterministic multi-scale approach [1] for poly-silicon MEMS resonators. A set of SVEs is first generated under the form of Voronoi tessellations with a random orientation assigned for each silicon grain of each SVE. The resolution of each micro-scale boundary problem is performed by recourse to the computational homogenization framework, e.g. [2], leading to meso-scale material properties under the form of a linear material tensor for each SVE. Applying a Monte-Carlo procedure allows a distribution of this material tensor to be determined at the meso-scale. The correlation between the meso-scale material tensors of two SVEs separated by a given distance can also be evaluated. A generator of the meso-scale material tensor is then implemented using the spectral method [3]. The generator [1] accounts for a lower bound [4] of the meso-scale material tensor in order to ensure the existence of the second-order moment of the Frobenius norm of the tensor inverse [5]. A macro-scale finite element model of the beam resonator can now be achieved using regular finite-element, i.e. not conforming with the grains, and the material tensor at each Gauss point is obtained using the meso-scale generator, which accounts for the spatial correlation. A Monte-Carlo method is then used at the macro-scale to predict the probabilistic behavior of the MEMS resonator. As an example the beam resonator illustrated in Fig. 1(a) is made of poly-silicon, and each grain has a random orientation. Solving the problem with a full direct numerical simulation combined to a Monte-Carlo method allows the probability density function to be computed as illustrated in Fig. 1(b). However this methodology is computationally expensive due to the number of degrees of freedom required to study one sample. The proposed non-deterministic multi-scale strategy allows reducing this computational cost as the Monte-Carlo processes are applied on much smaller finite-element models. The method can also be applied in the context of fracture of thin poly-silicon film [6]. In this case, a set of meso-scopic cohesive laws can be obtained at the meso-scale from the resolution of different SVEs. The meso-scopic cohesive laws are obtained for each RVE from the finite element resolution of the Voronoi tessellations using the method proposed in [7]. The resulting statistical values for the critical energy release rate and for the critical strength can then be used for macro-scale simulations. [less ▲]

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See detailTechnology Assessment in East Asia: Experiences and New Approaches
Moniz, Antonio; Yoshizawa, Go; Van Oudheusden, Michiel ULg

Conference (2015, February 25)

Integrating social and ethical concerns in innovation practice is a well-documented and debated issue in the United States and in Europe (namely through the EU-wide PACITA project). Related developments ... [more ▼]

Integrating social and ethical concerns in innovation practice is a well-documented and debated issue in the United States and in Europe (namely through the EU-wide PACITA project). Related developments in other parts of the world are less discernible – at least to Westerns. Yet, as witnessed by the emergence of technology assessment (TA) in countries like Japan, TA and TA-like activities have a unique and long history and continue to play a role in contemporary STI processes (e.g. in the area of citizen engagement with nanotechnologies, or energy policy). Taking these observations as its entry point, this panel asks how STI governance is locally enacted in Asian knowledge-driven economies. Like their Western counterparts, nations like China, Indonesia, Japan, the Republic of Korea, Singapore, Taiwan, etc., have undergone, and continue to undergo, rapid science- and technology-driven industrialization. In these processes, TA and TA-like activities develop with STI policies and programs and typically do so in nation- and region-specific ways. To render these processes, policies, and programs visible, and understand their implications for STI governance, this panel will discuss contributions that: • Describe and conceptualize how TA and TA-like activities have emerged in Asian KBEs, and in what particular forms (e.g. academic and parliamentary TA programs, linked to certain technologies and/or actors, which methods are used and why, etc.). • Reflect how these activities has evolved with, sustained, and/or countered, STI policies on the regional, national, and international level. • Compare and contrast how TA is, or is not, institutionalized in Asian countries and regions, e.g. through initiatives to initiate or abolish various TA forms, such as health TA, early-warning TA, and parliamentary TA; and/or point to prospects for TA capacity building. • Situate the above processes within a broader theory of, and movement towards, new STI governance frameworks, such as anticipatory governance, responsible innovation, public engagement, and/or others. By placing the development in historical, sociological, and comparative perspective, the panel seeks to open a space for critical reflection on the potential, problems, and limitations of initiating TA in Asia and draw connections to STI governance processes in other KBEs across the globe. [less ▲]

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See detail10. Perspectives - 1. La Lutte contre les pucerons grâce aux odeurs: développement d'une formulation phéromonale
Fassotte, Bérénice ULg; Vandereycken, Axel ULg; Chevalier Mendes Lopes, Thomas ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail6. Lutte intégrée contre les maladies
Bataille, Charlotte; Duvivier, Maxime; Eylenbosch, Damien ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detailThe AgMIP Soil and Crop Rotation Initiative
Basso, Bruno; Dumont, Benjamin ULg; Shcherbak, Iurii et al

Conference (2015, February 25)

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See detail10. Perspectives - 2. Utilisation de l'imagerie hyperspectrale proche infrarouge pour estimer la biomasse racinaire d'une culture de froment
Eylenbosch, Damien ULg; Fernandez Pierna, Juan Antonio; Baeten, Vincent et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail7. Lutte intégrée contre les ravageurs - 2.1 Suivi des populations de cécidomyie équestre, Haplodiplosis marginata, grâce au développement d'un piège à phéromone
Censier, Florence ULg; Fischer, Christophe ULg; Chavalle, Sandrine et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail4. La fumure azotée
Meza Morales, Walter ULg; Monfort, Bruno; Dumont, Benjamin ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail5. Régulateurs de croissance
Henriet, François; Monfort, Bruno; Meza Morales, Walter ULg

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail2. Implantation des cultures
Eylenbosch, Damien ULg; Meza Morales, Walter ULg; Monfort, Bruno et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detailA propos des fonctions continues nulle part dérivables
Esser, Céline ULg

Conference (2015, February 24)

En 1872, Karl Weierstrass choqua la communauté mathématique en présentant une famille de fonctions continues nulle part dérivables. Après la publication de ce résultat, beaucoup d'autres mathématiciens ... [more ▼]

En 1872, Karl Weierstrass choqua la communauté mathématique en présentant une famille de fonctions continues nulle part dérivables. Après la publication de ce résultat, beaucoup d'autres mathématiciens apportèrent leur propre contribution en construisant d'autres fonctions continues et nulle part dérivables. Dans cet exposé, nous présenterons les fonctions de Weierstrass. De plus, nous montrerons que le th eorème de Baire permet d'affirmer que l'ensemble des fonctions nulle part dérivables est dense dans l'ensemble des fonctions continues. Nous étudierons également la régularité ponctuelle de telles fonctions en utilisant la notion d'exposant de Hölder. [less ▲]

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See detailCover Songs Retrieval and Identification
Osmalsky, Julien ULg

Conference (2015, February 24)

Cover songs retrieval is a MIR task that has been widely studied in the recent years. The task, in its general sense, consists in retrieving covers for a given audio query. In this PhD, we focus on the ... [more ▼]

Cover songs retrieval is a MIR task that has been widely studied in the recent years. The task, in its general sense, consists in retrieving covers for a given audio query. In this PhD, we focus on the more specific task of cover songs *identification*. Given an unknown cover song query, we want to find relevant information about the original song, such as the title, the artist etc. Applications are live music recognition, plagiarism detections, query by examples, etc. Our approach is based on a pruning algorithm, whose role is to discard as quickly as possible as many tracks as possible from a search database in order to keep a smaller subset that should contain the tracks relevant to the query. We introduce the concept of *rejectors* for the pruning algorithm, which are single or combined classifier using multiple audio features for selecting relevant tracks. [less ▲]

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See detailInorhanic and organic carbon spatial variability in the Congo River during high waters (December 2013) and low waters (June 2014)
Borges, Alberto ULg; Bouillon, S; Teodoru, C et al

Conference (2015, February 23)

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See detailRegional organizations, international norms and global governance of culture: The EU foreign policy and the diversity of cultural expressions
Vlassis, Antonios ULg

Conference (2015, February 19)

Abstract: The aim of this paper is to explore empirically and qualitatively the links between regional organizations and international norms, by using an institutionalism centered on the actors. It seeks ... [more ▼]

Abstract: The aim of this paper is to explore empirically and qualitatively the links between regional organizations and international norms, by using an institutionalism centered on the actors. It seeks thus to analyze the European Union (EU)’s capacity to act within the global governance of culture, and in particular its ability to promote the Convention on diversity of cultural expressions (CDCE) beyond the EU. What is at issue is of why and how the EU foreign cultural policy (EUFCP) uses the CDCE and its normative framework, of what purposes as well as of how the CDCE influences the EUFCP and its objectives. I argue that the CDCE offers an opportunity for the European Commission to establish itself as a foreign policy actor in cultural affairs. Nevertheless, I point out that the disconnect between the Commission and the EU culture organizations is a serious constraint for the effectiveness of the EUFCP, highlighting that the promotion of the CDCE has been especially instrumental in consolidating the Commission’s actorness in external cultural affairs. And finally, I conclude that not only the Commission’s practices largely rely on the willingness of some member states with strong interests in the cultural area, but also the EU’s interpretations on the scope and the goals of the CDCE are far from convergent. Consequently, the Commission’s ability to be a EUFCP’s agent clearly depends on the sensitiveness of the issue and the EU’s actorness is strongly linked to the context in which the EUFCP is made. [less ▲]

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See detailFrom psychometric research to implementation and back: selected examples
Magis, David ULg

Conference (2015, February 13)

Current psychometric research is most often supported by computer software. New research perspectives often imply intensive simulation studies to validate the tested theories or hypotheses, and therefore ... [more ▼]

Current psychometric research is most often supported by computer software. New research perspectives often imply intensive simulation studies to validate the tested theories or hypotheses, and therefore require accurate implementation as e.g., R packages. However, it may happen that unexpected psychometric phenomena are detected almost accidentally, through such implementations with basically totally different purposes. This talk will illustrate this phenomenon by means of two recent examples from item response theory (IRT) with polytomous models: (a) the equivalence between the weighted likelihood estimator (WLE) and the Bayes modal estimator with Jeffreys prior, and (b) the relationships between observed and expected information functions. Rather than focusing on the technical details, the purpose of this talk is to highlight how the results were identified first through R implementation, then confirmed by theoretical derivations. The talk concludes by advocating for flexible and stable open-source implementations (such as R packages) to support current and ongoing psychometric research. [less ▲]

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See detailAdoption by gay and lesbian parents: a cross-nationale study
Messina, Roberta ULg; D'Amore, Salvatore ULg; Green, Robert-J

Poster (2015, February 13)

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See detailEncourager un vieillissement cognitif sain par un travail adapté (work shop)
Grotz, Catherine ULg; Adam, Stéphane ULg

Conference (2015, February 12)

L'objectif du workshop est d'apporter des éléments pratiques/cliniques en faveur d'un vieillissement cognitif de qualité, y compris une discussion des mesures à mettre en place en ce qui concerne l ... [more ▼]

L'objectif du workshop est d'apporter des éléments pratiques/cliniques en faveur d'un vieillissement cognitif de qualité, y compris une discussion des mesures à mettre en place en ce qui concerne l'employabilité de la population active plus âgée. [less ▲]

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See detailAn Alternative to Semantics?
Gauvry, Charlotte ULg

Conference (2015, February 12)

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See detailCheckpoints modulation by the human T-lymphotropic virus type 1 (HTLV-1) Tax protein : towards new therapeutic approaches
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Boxus, Mathieu et al

Poster (2015, February 11)

HTLV-1 infects approximately 20 million people worldwide and causes several diseases. This virus is responsible for the adult T-cell leukemia (ATL) and for a chronic neuropathology (TSP/HAM). There is ... [more ▼]

HTLV-1 infects approximately 20 million people worldwide and causes several diseases. This virus is responsible for the adult T-cell leukemia (ATL) and for a chronic neuropathology (TSP/HAM). There is currently no satisfactory treatment for these diseases. Among the proteins encoded by HTLV-1, Tax appears to play an important role in the mechanisms leading to pathogenicity. We are interested in the mechanisms of cell transformation by HTLV-1 and more particularly in the interplay between the viral Tax oncoprotein and the DNA damage response (DDR). We demonstrate that transient expression of Tax results in DNA damage, cell cycle arrest and activation of the ATM-Chk2-p53 axis of the DDR. In fibroblasts, cell cycle arrest occurs at the G1 and G2 phases depending on the p53 background. Despite Tax expression hampers cell cycle progression, neither pro-apoptotic nor pro-senescent effects are observed. In contrast, HTLV-1 infected lymphocytes proliferate continuously and appear to be adapted to the checkpoints. This mechanism allows infected lymphocytes to proliferate despite the presence of genomic lesions. Those cells might thus rely on effective DNA repair mechanisms. Indeed, we show that Tax expressing cells activate the error free repair mechanism homologous recombination (HR). Inhibition of ATM, involved in DDR and DNA repair by HR, impedes Tax-mediated cellular transformation. Depending on these observations, we propose a novel therapeutic approach based on the principle of synthetic lethality. [less ▲]

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See detailReprogramming of replication origin firing and checkpoint adaptation in adult T-cell leukemia
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Boxus, Mathieu et al

Conference (2015, February 11)

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the ... [more ▼]

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). A key parameter of HTLV-1 pathogenesis is faster replication of provirus-carrying lymphocytes allowing clonal expansion of infected cell populations. The virally-encoded Tax oncoprotein plays an essential role in this process by interacting with DNA replication origins and accelerating S phase progression. By reprogramming the timing of origin firing, Tax also creates a replicative stress leading to DNA double strand breaks. This mechanism further triggers the DNA damage response (DDR) that induces cell cycle arrest and initiates either apoptosis or senescence. However, HTLV-1 infected cells have developed strategies to interfere with the DDR and are adapted to checkpoint control. These cells are thus able to proliferate despite occurrence of DNA damage. Based on these observations, we now propose a novel therapeutic approach based on the principle of synthetic lethality. [less ▲]

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See detailLes premiers enseignements de l'enquête auprès des élevages laitiers sur leurs évolutions technico-économiques
Beckers, Yves ULg; Vanwindekens, Frédéric ULg; Wyzen, Benoît et al

in Carrefour des Productions animales, 20ème édition "L'exploitation laitière wallonne de demain : du point de vue des acteurs aux propositions de la reccherche" (2015, February 11)

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See detailRisk of emergence of a hyperpathogenic bovine leukemia virus by mutation of a single envelope N-linked glycosylation site
De Brogniez, Alix ULg; Bouzar, Amel-Baya; Jacques, Jean-Rock ULg et al

Poster (2015, February 11)

- Introduction : Pathogens have co-evolved with their host to ensure efficient replication and transmission without inducing excessive pathogenicity that would indirectly impair their persistence. This is ... [more ▼]

- Introduction : Pathogens have co-evolved with their host to ensure efficient replication and transmission without inducing excessive pathogenicity that would indirectly impair their persistence. This is exemplified by the bovine leukemia virus (BLV) system in which lymphoproliferative disorders develop in ruminants after latency periods of several years. Infection of sheep and cattle with BLV is a model system for the related human T-lymphotropic virus type 1 (HTLV-1) responsible for Adult T-cell Leukemia (ATL). - Aims : The goal of this work is to investigate the role of N-glycans of the viral envelope protein during viral replication and pathogenesis. - Methods and results : Using glycosylation inhibitors and lectins, we showed that N-glycosylation is involved in viral infection (i.e. cell-to-cell fusion). Using reverse genetics of an infectious molecular provirus, we next demonstrated that a particular N-linked envelope glycosylation site (N230) limits viral replication and pathogenicity in vitro and in vivo. We have thus generated a viral mutant that is more pathogenic than the wild type strain. - Conclusions : To our knowledge, this is the first time that a hyperpathogenic BLV has been identified. This unexpected observation has important consequences in terms of disease control and managing. Indeed, during evolution, pathogens and their hosts should achieve an equilibrium allowing the coexistence of the two species. Occurrence of this particular mutation may thus represent a potential threat associated with emergence of hyperpathogenic BLV strains and possibly of new variants of the related HTLV-1. [less ▲]

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See detailL'exploitation laitière de demain : présentation de l'enquête
Beckers, Yves ULg

Conference (2015, February 11)

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See detailFrom scientific expertise to lived experiences of genetic diseases. On patients’ organisations’ involvement in the construction of the medical evidence
Duysens, Fanny ULg

Conference (2015, February 11)

Genomic medicine is currently an expanding field. Based on the complete sequencing of the human genome, recent innovations promote the development of new protocols of diagnostic and treatments against ... [more ▼]

Genomic medicine is currently an expanding field. Based on the complete sequencing of the human genome, recent innovations promote the development of new protocols of diagnostic and treatments against hereditary genetic diseases. Thereby, they create opportunities which can disrupt the relationships between involved actors, such as patients and their relatives, concerned organisations, medical experts, as well as genomics specialists and health policy managers. This presentation exposes the baseline questions of a research project interested in some Belgian patients’ organisations’ involvement in issues related to genetic diseases within this current context, especially in the construction of the so-called "scientific and medical evidence". It addresses its expansion to patients' experiential knowledge which is based on their lived experiences of health and disease. [less ▲]

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See detailL'exploitation laitière de demain : conclusions
Beckers, Yves ULg

Conference (2015, February 11)

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See detailHDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism
Hendrick, Elodie ULg; Peixoto, Paul ULg; Polese, Catherine ULg et al

Poster (2015, February 11)

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum ... [more ▼]

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum inhibitors of these enzymes such as SAHA can inhibit tumor growth both in vitro and in vivo and are currently used as anti-cancer agents in clinic. For many years, we are investigating the specific role of individual HDAC members in cancer biology and we have recently demonstrated that specific depletion of HDAC5 using siRNA technology reduced cancer cells proliferation and survival1 The goal of this study is to further understand the molecular mechanisms of action of HDAC5 in cancer cells. Screening transcriptomic study demonstrated that HDAC5 depletion induces a down-regulation of subunits of the complex I of the mitochondrial respiratory chain (NDUFB5-NDUFA3) as well as anti-oxydant proteins (Ferritin, Metalothionein,¿) through modulation of mRNA stability. Therefore, HDAC5 depletion causes a significant increase of ROS production inducing both apoptosis and mechanisms of mitochondria quality control (mitophagy and mitobiogenesis). This HDAC5 depletion-induced mitochondrial dysfunction provokes metabolic adaptation associated with increased importance of glucose and glutamine. Indeed, interference with both glucose and glutamine supply in HDAC5-depleted cancer cells significantly increases apoptotic cell death suggesting that glucose or glutamine deprivation might be combined to HDAC5 inhibition as a therapeutic strategy to kill cancer cells. Our study demonstrated for the first time that specific HDAC5 inhibition induces metabolic reprogramming and provides insight into a valuable experimental strategy for manipulation of specific HDAC5 inhibition and glucose metabolism in therapy against cancer. 1.Peixoto, P. et al. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell death and differentiation, 2012; 1-14. Presenting author e-mail: elodie.hendrick@student.ulg.ac.be [less ▲]

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See detailZones humides : entre modifications environnementales et actions humaines
Ozer, Pierre ULg

Conference (2015, February 08)

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See detailIntérêt du signal T2 des adénomes hypophysaires à GH traités par analogues de la somatostatine - premiers résultats de l'étude IRMA#2
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

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See detailThe return of Turkey to the Western Balkans: a challenge or an opportunity for the European Union ?
Lika, Liridon ULg

Conference (2015, February 07)

In the new Turkish doctrine, besides the great interests in Central Asia, Middle East, Africa and the Caucasus, the Balkans are also important. Turkey is making great efforts to play a greater role on the ... [more ▼]

In the new Turkish doctrine, besides the great interests in Central Asia, Middle East, Africa and the Caucasus, the Balkans are also important. Turkey is making great efforts to play a greater role on the international scene and creates its area of interest, especially where the links of Ottoman legacy can help. Although it is defined as a peaceful power in the region, some describe it as neo-ottoman, a term rejected by the Turkish authorities because of its possible imperialist connotation. This paper aims precisely to study the return of Turkey to the Balkans. Our central question is: what is the purpose of the Turkish foreign policy in the Western Balkans? Related issues will be addressed such as: is there a competition between Turkey and the European Union in this area? What are the specifics of Turkish foreign policy? In order to explore these research questions, this study focuses on the concept of soft power through which Turkey extends its power. Indeed, the Turkish government imposes itself on the Balkans not by force but with the help of economics, diplomacy, trade, culture and religion. Following the crisis in the EU, causing the collapse of Western investment and a relative decrease of attraction for the Balkans, Turkey has taken advantage of the situation in order to increase its influence in all areas. This contribution will proceed in three stages. Firstly, we will make an analysis of the authors of soft power to think about the character of the new Turkish geopolitical doctrine. Secondly, we are going to apply this theoretical framework to the case study identified, namely the influence of Turkey in the Western Balkan countries. Finally, we will show if exists a competition or a cooperation between Turkey and European Union in the Western Balkans. [less ▲]

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See detailLa pérennisation des partenariats publics-privés dans le champ de l’emploi : entre application, interprétation et ajustement du cadre réglementaire
Remy, Céline ULg; Gérard, Julie ULg; Beuker, Laura ULg

Conference (2015, February 07)

Dans une perspective de gestion mixte du marché du travail, les services publics de l’emploi sont invités, par la Convention 181 de l’OIT de 1997, à déléguer et à confier l’exploitation et la gestion de ... [more ▼]

Dans une perspective de gestion mixte du marché du travail, les services publics de l’emploi sont invités, par la Convention 181 de l’OIT de 1997, à déléguer et à confier l’exploitation et la gestion de leurs activités à des opérateurs privés de service, dans le cadre d’une entente contractuelle. Alors que les modalités de la collaboration (telles que le public-cible, le type et le nombre d’accompagnements dispensés, les résultats à atteindre, etc.) sont fixées, initialement, par les services publics de l’emploi, elles sont ensuite mises en pratique par les diverses parties-prenantes du partenariat. Les acteurs publics et privés exploitent la part de latitude inhérente à leur fonction pour interpréter et ajuster les termes du contrat ou pour pouvoir réaliser leur mission d’accompagnement des demandeurs d’emploi. Partant du postulat que la règle est incomplète, notre objectif est d’analyser la mise en œuvre du partenariat en saisissant les arguments avancés par les acteurs pour justifier et légitimer leurs actions. À partir de cette analyse, nous montrerons que les acteurs du partenariat doivent interpréter les règles – écart entre le travail prescrit et le travail effectivement presté – dans leurs pratiques quotidiennes. Agissant comme des « pseudo » street-level bureaucrats, ces derniers usent de leur pouvoir pour ajuster les règles. En outre, il semblerait que ces pratiques d'indiscipline permettent, en réalité, de maintenir les relations partenariales entre services publics de l’emploi et opérateurs privés, et d’œuvrer, in fine, à la pérennisation de celles-ci dans le champ de l’emploi. Nous appuierons notre analyse sur un matériau empirique composé d’observations participantes et d’entretiens semi-directifs réalisés auprès des parties-prenantes des PPP, situés en Belgique francophone. [less ▲]

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See detailNouvelle classification des acro-gigantismes
Rostomyan, Liliya ULg; Beckers, Albert ULg

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

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See detailA novel mutation of the luteinizing hormone/choionic gonadotrophin receptor gene leading to Leydig cell hypoplasia type I
Potorac, Iulia ULg; Rivero-Müller, A; Pintiaux, Axelle ULg et al

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

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See detailQuand science politique et droit dialoguent : quelle typologie des instruments mémoriels en fonction du degré de contrainte ?
Grandjean, Geoffrey ULg

Conference (2015, February 07)

Envisager les études sur la mémoire comme sous-champ de la science politique francophone ouvre des pistes enrichissantes pour les politologues, notamment lorsqu’ils sont amenés à analyser les instruments ... [more ▼]

Envisager les études sur la mémoire comme sous-champ de la science politique francophone ouvre des pistes enrichissantes pour les politologues, notamment lorsqu’ils sont amenés à analyser les instruments mémoriels régissant un ou plusieurs système(s) politique(s). Dans cette perspective, la communication vise à présenter, d’un point de vue épistémologique, les apports découlant de l’interaction entre les sciences politique et juridique dans le processus de consolidation des études sur la mémoire comme sous-champ disciplinaire de la science politique. Plus précisément, la communication vise à offrir une typologie des instruments mémoriels en fonction du degré de contrainte et d’imposition d’une mémoire officielle. Par exemple, une résolution adoptée par une assemblée législative est faiblement contraignante alors qu’une loi réprimant le négationnisme impose à la fois une mémoire officielle tout en sanctionnant pénalement les citoyens qui ne la respectent pas. La typologie passe en revue les multiples instruments mémoriels pouvant être adoptés par les autorités publiques : résolution, loi déclarative, loi pénale, plan de commémorations ou encore mise en valeur d’un lieu de mémoire. L’accent est mis sur les instruments mémoriels de deux pays francophones : la Belgique et la France. Au final, cette communication permet d’insister sur l’apport de la science politique en analysant l’exercice de prérogatives de puissance publique et sur l’apport de la science juridique en classifiant les types d’instruments mémoriels en fonction du degré de contrainte ; tout en faisant dialoguer des cas d’étude différents. [less ▲]

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See detailMédias et dette wallonne: polémique autour d'un indicateur de finances publiques
Piron, Damien ULg

Conference (2015, February 06)

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See detailComprendre les programmes électoraux : comparaison des méthodes d’encodage manuel et automatique
Piet, Grégory ULg; Dandoy, Régis; Joly, Jeroen

Conference (2015, February 06)

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See detailThe phosphorylation of RelA on Ser547 does not modulate NF-kB activation after TNFa treatment like after a genotoxic stress
Trussart, Charlotte ULg; Orban, Tanguy ULg; Di Valentin, Emmanuel ULg et al

Poster (2015, February 06)

NF-kB controls the expression of hundred of genes involved in inflammatory and innate responses, proliferation, survival, cancer initiation and progression. Numerous post-translational modifications of ... [more ▼]

NF-kB controls the expression of hundred of genes involved in inflammatory and innate responses, proliferation, survival, cancer initiation and progression. Numerous post-translational modifications of p65 modulating NF-kB transcriptional activity are known. We identified Ser547 as a new site of p65 phosphorylation targeted by ATM kinase, which coordinates the “DNA Damage Response” pathway in the event of DNA double-strand breaks. We demonstrated that the phosphorylation of Ser547 regulates the transcription of a sub-set of NF-κB dependent genes after genotoxic stress by modifying HDAC1 recruitment(1). Presently, we are investigating the role of this specific phosphorylation in an inflammatory context. We observe that the mutations of p65 (S547A or S547D) also affect the transcriptional potential of the NF-κB in a promoter specific manner after an exposition to TNFα and H2O2. The study of the molecular mechanism of this regulation after TNFα and H2O2 exposition are both in progress. [less ▲]

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See detailDaily intake and bacteriological quality of meat consumed in the households of Kigali city (Rwanda)
Niyonzima, Eugène; Ongol, Martin Patrick; Kimonyo, Anasthase et al

Poster (2015, February 05)

Meat is worldwidely known to be a nutrient rich food. It provides valuable amounts of proteins,vitamins such as retinol and vitamin B12 and minerals namely iron, selenium and zinc with an increased ... [more ▼]

Meat is worldwidely known to be a nutrient rich food. It provides valuable amounts of proteins,vitamins such as retinol and vitamin B12 and minerals namely iron, selenium and zinc with an increased bioavailability than found in other dietary sources [1]. Along the production chain, meat can get contaminated by a wide range of spoilage and/or pathogenic microorganisms from the farm, slaughtering environment and distribution. The actual number of foodborne infections attributable to meat is difficult to assess accurately, principally because only a small proportion of illness cases is officially reported. However, by using outbreak data published internationally, Greig and Ravel [2] reported that 12.7 % of reported foodborne outbreaks were attributable to beef while 10.5 and 4.6 % were associated with chicken and pork, respectively. According to the same authors, Salmonella spp. and pathogenic E.coli, respectively, were identified as the causal agents in 32.9 and 34.6 % of foodborne outbreaks of bacterial origin attributable to beef. The objective of this study was to determine the meat consumption pattern in different socio-conomical categories of the population of Kigali city and to assess the bacteriological quality of the consumed meat. [less ▲]

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See detailA mixed integer nonlinear programming bi-objective model for intermodal network design
Mostert, Martine ULg; Caris, An; Limbourg, Sabine ULg

Conference (2015, February 05)

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See detailRésistance aux antibiotiques : le retour à l’ère prébiotique ?
Galleni, Moreno ULg; Kerff, Frédéric ULg; Rigali, Sébastien ULg

Conference (2015, February 05)

Aujourd’hui, la résistance des bactéries aux antibiotiques relève d'une préoccupation croissante dans le domaine de la santé publique et s'impose plus que jamais comme une priorité. Ce problème a un coût ... [more ▼]

Aujourd’hui, la résistance des bactéries aux antibiotiques relève d'une préoccupation croissante dans le domaine de la santé publique et s'impose plus que jamais comme une priorité. Ce problème a un coût, sociétal et économique en Europe: 25.000 décès annuels par septicémie et 1,5 milliard d’euros d’augmentation du coût des traitements. Bien que le besoin de nouveaux agents antibactériens en milieu clinique est urgent, seules deux nouvelles classes d’antibiotiques ont pu être proposées durant ces 30 dernières années. En effet, la découverte et le développement de nouveaux antibiotiques posent des défis scientifiques, cliniques et financiers importants. [less ▲]

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See detailSite-specific height-diameter allometry of Central African moist forests
Loubota Panzou, Grâce Jopaul ULg; Doucet, Jean-Louis ULg; Fayolle, Adeline ULg

Poster (2015, February 04)

In this study we aimed to identify the variation in height-diameter allometry between forest types and among species in Central African moist forests. We also examined the consequences on biomass ... [more ▼]

In this study we aimed to identify the variation in height-diameter allometry between forest types and among species in Central African moist forests. We also examined the consequences on biomass estimation. Two forest sites in southern Cameroon with contrasting levels of deciduousness. Height and diameter were measured for a total of 521 trees belonging to 12 timber species over a large range of diameter, 10-240 cm for the Ma’an site and 11-182 cm for the Mindourou site. Non-destructive height measurements were calibrated with destructive measurements for a total of 60 trees, 30 in each site. Commercial forest inventory data (n=7253 0.5ha plots) were gathered for the Ma’an (n=34 samples and 2101 plots) and Mindourou (n=117 samples and 5152 plots) sites. A total of ten allometric models (including asymptotic and non-asymptotic models) were fitted to the height-diameter data at species (n=12) and site (n=2) level. Biomass estimates were computed based on forest inventory data and general allometric models using both site-specific and published height-diameter equations. Given the strong correlation between the non-destructive and destructive height measurements we had confidence in using the non-destructive height measurements to establish site- and species-specific height-diameter allometric equations. The height measurements performed over a wide range of diameters, 10-240 cm, tended to support an asymptotic shape (and most often the Michaelis Menten model) for the height-diameter allometry either at species and site level. We identified a significant difference in height-diameter allometry between the two study sites. For a given diameter, trees tended to be taller in the more semi-deciduous Mindourou site than in the more evergreen Ma’an site, with a maximum height of 39.5 and 46.5 m, respectively. The two sites significantly differed in stand structure and biomass. This difference is due to the variation in height-diameter allometry. Height-diameter allometry strongly varies between sites and site-specific height-diameter allometric equations should be developed to further improve the estimation of biomass and carbon stock contained in tropical forests. [less ▲]

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See detailReprogramming of replication origin firing and checkpoint adaptation in adult T-cell leukemia
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Boxus, Mathieu et al

Conference (2015, February 03)

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the ... [more ▼]

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). A key parameter of HTLV-1 pathogenesis is faster replication of provirus-carrying lymphocytes allowing clonal expansion of infected cell populations. The virally-encoded Tax oncoprotein plays an essential role in this process by interacting with DNA replication origins and accelerating S phase progression. By reprogramming the timing of origin firing, Tax also creates a replicative stress leading to DNA double strand breaks. This mechanism further triggers the DNA damage response (DDR) that induces cell cycle arrest and initiates either apoptosis or senescence. However, HTLV-1 infected cells have developed strategies to interfere with the DDR and are adapted to checkpoint control. These cells are thus able to proliferate despite occurrence of DNA damage. Based on these observations, we now propose a novel therapeutic approach based on the principle of synthetic lethality. [less ▲]

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See detailSuppression of Limit Cycle Oscillations using the Nonlinear Tuned Vibration Absorber
Habib, Giuseppe ULg; Kerschen, Gaëtan ULg

in Proceeding IMAC XXXIII A Conference and Exposition on Structural Dynamics, Orlando 2-5 February 2015 (2015, February 03)

The objective of the present study is to mitigate, or even completely eliminate, the limit cycle oscillations in mechanical systems using a passive nonlinear absorber, termed the nonlinear tuned vibration ... [more ▼]

The objective of the present study is to mitigate, or even completely eliminate, the limit cycle oscillations in mechanical systems using a passive nonlinear absorber, termed the nonlinear tuned vibration absorber (NLTVA). An unconventional aspect of the NLTVA is that the mathematical form of its restoring force is not imposed a priori, as it is the case for most existing nonlinear absorbers. The NLTVA parameters are determined analytically using stability and bifurcation analyses, and the resulting design is validated numerically using the MATCONT software. The proposed developments are illustrated using a Van der Pol-Du ng primary system. [less ▲]

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See detailMBD du laboratoire à la clinique
CAVALIER, Etienne ULg

Conference (2015, February 02)

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See detailCore-shell AgSiO2-Protoporphyrin IX nanoparticle: Effect of the Ag core on reactive oxygen species generation
Lismont, Marjorie ULg; Pàez Martinez, Carlos ULg; Dreesen, Laurent ULg

in SPIE proceeding - Colloidal Nanoparticles for Biomedical Applications X (2015, February)

Photodynamic therapy (PDT) for cancer is based on the use of a light sensitive molecule to produce, under specific irradiation, toxic reactive oxygen species (ROS). A way to improve the therapy efficiency ... [more ▼]

Photodynamic therapy (PDT) for cancer is based on the use of a light sensitive molecule to produce, under specific irradiation, toxic reactive oxygen species (ROS). A way to improve the therapy efficiency is to increase the amount of produced ROS near cancer cells. This aim can be achieved by using a metal enhanced process arising when an optically active molecule is located near a metallic nanoparticle (NP). Here, the coupling effect between silver (Ag) NPs and protoporphyrin IX (PpIX) molecules, a clinically approved photosensitizer, is studied compared first, to PpIX fluorescence yield and second, to ROS production efficiency. By applying a modified Stöber process, PpIX was encapsulated into a silica (SiO2) shell, surrounding a 60 nm sized Ag core. We showed that, compared to SiO2-PpIX NPs, Ag coated SiO2-PpIX NPs dramatically decreased PpIX fluorescence together with singlet oxygen production efficiency. However, after incubation time in the dark, the amount of superoxide anions generated by the Ag doped sample was higher than the control sample one. [less ▲]

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See detailSingle-Molecule Force Spectroscopy on Synthetic Helical Nanoarchitectures
Devaux, Floriane ULg; Duwez, Anne-Sophie ULg; Huc, Ivan et al

Poster (2015, February)

Foldamers are artificial folded molecular architectures inspired by the structures and functions of natural biopolymers. Folding is the process selected by nature to control the conformation of its ... [more ▼]

Foldamers are artificial folded molecular architectures inspired by the structures and functions of natural biopolymers. Folding is the process selected by nature to control the conformation of its molecular machinery to carry out chemical functions and mechanical tasks, such as en-zyme catalysis, duplication in nucleic acids, force generation,... During the last decade of research on foldamers [1], synthetic oligomers able to adopt well-defined and predictable folded conformations, such as helices, have been proposed. Recent progress has shown that stepwise chemical synthesis and molecular design based on aromatic oligoamide backbones enable to produce large helically folded molecular architectures. The shape and stiffness of the backbone, local conformational preferences, specific interactions between distant monomers in sequences, as well as the action of external parameters such as the solvent or the presence of ions, can be combine to induce folding tendency. A remarkable aspect of these architectures is that they can give rise to folded patterns that have no in natural counterparts biopolymer structures. For instance, helices whose diameter varies along the se-quence, helices possessing a handedness inversion centre, herringbone helices have been reported. The objective of the project is to synthesize various helical nanorchitectures based on an oli-goamide aromatic backbone and to obtain a detailed picture of their dynamical conformation in solution, as well as, their mechanochemical properties, by AFM-based single molecule force spectroscopy. It is worth mentioning that an important sub-objective of this project is to probe intramolecular interactions in small synthetic molecules with the AFM. Indeed, whereas single-molecule force spectroscopy on macromolecules (proteins and synthetic polymers) is widely exploited[2], implementing single-molecule force spectroscopy on small molecules, such as the foldamers proposed here, remains a major challenge[3]. [1] For a review, see G. Guichard and I. Huc, Chem. Commun. 2011, 47, 5933–5941. [2]E. M. Puchner, H. E.Gaub, Curr. Opin. Struct. Biol. 2009, 19, 605–614. [3]P. Lussis, A.-S. Duwez, Nature Nanotech. 2011, 6, 553-557 [less ▲]

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See detailRobust impact design of steel and composite building structures: the alternate load path approach
Hoffmann, Nadine; Kuhlmann, Ulrike; Demonceau, Jean-François ULg et al

in Proceeding of the IABSE Workshop - Safety, Robustness and Condition Assessments of Structures (2015, February)

Vulnerability of structures to progressive collapse and mitigation of the effects of local damages are topics widely discussed. The studies worldwide carried out allowed identifying different design ... [more ▼]

Vulnerability of structures to progressive collapse and mitigation of the effects of local damages are topics widely discussed. The studies worldwide carried out allowed identifying different design strategies. However, specific knowledge is still limited and this gap is apparent in codes of practice. A European project focusing on robustness of steel and steel and concrete composite structures regarding the effects of impact recently started combining the 2 methods of residual strength and alternate load path. In the framework of the project activities, the Authors aimed their studies on the redundancy of the structure through slab-beam-systems and ductile joint as well as on the local behaviour of the impacted members. For this analytical, numerical and experimental investigations have been planned and executed. The paper describes the experimental activities related to the investigations on the structural redundancy and presents the preliminary test outcomes. [less ▲]

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See detailMolecular diversity of microorganisms in Antarctic lacustrine microbial mats
Wilmotte, Annick ULg; Stelmach Pessi, Igor ULg; Sweetlove, Maxime et al

Conference (2015, February)

The BeSPO project CCAMBIO aims to study the biogeographical distribution of microorganisms in lacustrine microbial mats using a combination of techniques including microscopical observations (light and ... [more ▼]

The BeSPO project CCAMBIO aims to study the biogeographical distribution of microorganisms in lacustrine microbial mats using a combination of techniques including microscopical observations (light and electronic), strain isolation, and molecular diversity assessment using Next Generation Sequencing. The samples were collected in different Antarctic and sub-Antarctic biogeographical regions. A multivariate analysis of diatoms showed that these regions hosted different diatom flora. Endemic diatom taxa were also observed, and a multigene molecular phylogeny of Pinnularia borealis showed a high genetic diversity. A new Scenedesmacean species was described from Antarctica, Chodatodesmus australis. A comparison of the bacterial diversity retrieved by cultivation or NGS showed a complementarity of both approaches and differences when different variable regions of the 16S rRNA gene were used. Novel and unclassified sequences, also observed by other authors, were obtained. Pilot studies were conducted for the microeukaryotes and cyanobacteria to select NGS protocols and bioinformatic pipelines. The purpose is to deposit the diversity data in the “Microbial Antarctic Resource System (MARS)” presently developed into the webportal ‘biodiversity.aq’. [less ▲]

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See detailAnalytical procedure to derive P-I diagram of a beam under explosion
Hamra, Lotfi ULg; Demonceau, Jean-François ULg; Denoël, Vincent ULg

in Proceeding of the IABSE Workshop - Safety, Robustness and Condition Assessments of Structures (2015, February)

The aim of this paper is to study a beam extracted from a frame and subjected to blast loading. The demand of ductility depends on six dimensionless parameters: two related to the blast loading, two ... [more ▼]

The aim of this paper is to study a beam extracted from a frame and subjected to blast loading. The demand of ductility depends on six dimensionless parameters: two related to the blast loading, two referring to the bending behaviour of the beam and two corresponding to the dynamic behaviour of the rest of the structure. We develop a full analytical procedure that provides the ductility demand as a function of these six dimensionless parameters. [less ▲]

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See detailRugose corals from the Carboniferous of the eastern Tafilalt (Morocco): a progress report
Aretz, Markus; Denayer, Julien ULg

Conference (2015, February)

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See detailCyanobacteria - the constructors of travertines?
Kleinteich, Julia; Stelmach Pessi, Igor ULg; Velazquez, David et al

Conference (2015, February)

Cyanobacteria are participating in carbonate build-up and travertine formation in the Belgian river Hoyoux and its tributaries. In this study, we sampled calcareous material from travertines and oncoliths ... [more ▼]

Cyanobacteria are participating in carbonate build-up and travertine formation in the Belgian river Hoyoux and its tributaries. In this study, we sampled calcareous material from travertines and oncoliths from four sampling sites on the Hoyoux river and Triffoy brook. In addition, the water chemistry was determined. The structure of the material was analyzed by Scanning Electron Microscopy and Raman microscopy (?°. The dominant cyanobacterial species was isolated and identified on the basis of microscopic observation and amplification of the 16S-ITS fragment as Phormidium sp., likely functioning as the ‘architect’ of the travertine system. In order to describe the full diversity of the travertine system and to discriminate between the active fraction and inactive or dead organic matter, DNA as well as RNA was extracted from the travertine material, amplified using cyanobacteria specific primers and sequenced by 454 pyrosequencing. To detect seasonal changes in the biological activity, summer and winter time points were compared. This study reveals the ecology of an overlooked environment in Belgian river systems and tries to explain the build-up of travertines. [less ▲]

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See detailAzione, testualizzazione, notazione
Dondero, Maria Giulia ULg

in Espressione e contenuto. Rivista on-line dell'AISS Associazione Italiana di Studi Semiotici (2015, February), 18/19

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See detailLes PPP comme nouveau mode de régulation du marché de l'accompagnement des demandeurs d'emploi. A chaque modèle de partenariat son type de stratégie
Remy, Céline ULg

in Cahiers Loyola (2015, February), 1

Cette communication vise à montrer en quoi les partenariats publics-privés (PPP) constituent désormais un nouveau mode de régulation du marché de l’accompagnement des demandeurs d’emploi. Les services ... [more ▼]

Cette communication vise à montrer en quoi les partenariats publics-privés (PPP) constituent désormais un nouveau mode de régulation du marché de l’accompagnement des demandeurs d’emploi. Les services publics de l’emploi (SPE) doivent établir des PPP avec des prestataires de service pour la mise en place de formation à destination des demandeurs d’emploi. La réalisation de trois études de cas au sein des SPE, dont deux en Belgique et une en Suisse, nous permet de mettre en évidence une forte influence du modèle de gestion du PPP sur la collaboration entre les parties-prenantes mais aussi sur les stratégies développées par les prestataires pour surmonter les problèmes liés à la collaboration avec l’Office de l’Emploi et à la mise en place de la prestation de service. [less ▲]

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See detailScanning the genome for QTL affecting the recombination process in the male and female cattle germline
Kadri, Naveen Kumar ULg; Harland, Chad ULg; Coppieters, Wouter ULg et al

Poster (2015, February)

We herein study genetic recombination in three dairy cattle population from France, New-Zealand and The Netherlands. We apply a new phasing algorithm extracting familial information suited for large half ... [more ▼]

We herein study genetic recombination in three dairy cattle population from France, New-Zealand and The Netherlands. We apply a new phasing algorithm extracting familial information suited for large half-sib families to reconstruct haplotypes and detect cross-overs. The software is robust to genotyping errors and map errors (genome builts still contain errors for non-model organisms). We identify more than 2,000,000 cross-over events in sperm cells transmitted by 2942 sires to 94,049 offspring, and more than 500,000 cross-over events in oocytes transmitted by 10,943 cows to 23,850 offspring. The estimated number of cross-overs per gamete and its accuracy were influenced by the family structure (number of offsprings, parents and grand-parents genotyped). The average number of cross-overs in males (24.0) was larger than in females (21.8), even after correction for family structure. In males, recombination rates were higher closer to telomeres whereas in females, recombination rates dropped at both centromeres and telomeres (probably as a result of lower informativity). The heritability of the global recombination rate was close to 0.20 in males and to 0.10 in females and the genetic correlation was ~0.70, indicating that common genes are influencing both traits. Genome-wide association studies clearly confirmed QTL located close to REC8 and RNF212 in males. The QTL associated to REC8 was also detected in females and there was a positive correlation between QTL effects in males and females. The QTL associated to REC8 accounted for ~10% of the genetic variance in both males and females. [less ▲]

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See detailThe Late Viséan Rugose coral association of NW Turkey
Denayer, Julien ULg

Conference (2015, February)

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See detailLes procédures secondaires sous l'empire du nouveau Règlement insolvabilité
Wautelet, Patrick ULg

Conference (2015, February)

Cette présentation tire le bilan d'une dizaine d'années d'application des dispositions du Règlement 1346/2000 relatives aux procédures secondaires et trace les contours du nouveau régime des procédures ... [more ▼]

Cette présentation tire le bilan d'une dizaine d'années d'application des dispositions du Règlement 1346/2000 relatives aux procédures secondaires et trace les contours du nouveau régime des procédures secondaires sous l'empire du Règlement révisé [less ▲]

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See detailBridging the gap between Nonlinear Normal Modes and Modal Derivatives
Sombroek, Cees; Renson, Ludovic ULg; Tiso, Paolo et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

Nonlinear Normal Modes (NNMs) have a clear conceptual relation to the classical linear normal modes (LNMs), yet they offer a solid theoretical framework for interpreting a wide class of non-linear ... [more ▼]

Nonlinear Normal Modes (NNMs) have a clear conceptual relation to the classical linear normal modes (LNMs), yet they offer a solid theoretical framework for interpreting a wide class of non-linear dynamical phenomena with no linear counterpart. The main difficulty associated with NNMs is that their calculation for large-scale models is expensive, particularly for distributed nonlinearities. Repeated direct time integrations need to be carried out together with extensive sensitivity analysis to reproduce the frequency-energy dependence of the modes of interest. In the present paper, NNMs are computed from a reduced model obtained using a quadratic transformation comprising LNMs and Modal Derivatives (MDs). Previous studies have shown that MDs can capture the essential dynamics of geometrically nonlinear structures and can greatly reduce the computational cost of time integration. A direct comparison with the NNMs computed from another standard reduction technique highlights the capability of the proposed reduction method to capture the essential nonlinear phenomena. The methodology is demonstrated using simple examples with 2 and 4 degrees of freedom. [less ▲]

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See detailLordose et/ou xyphose chez le porc : mise à l’épreuve de l’hypothèse héréditaire
Laitat, Martine ULg; Veillat, Emilie; Van Cauwenberge, Henry et al

Poster (2015, February)

Lordosis and/or kyphosis, also called ”dipped shoulder” or ”humpy‐back” is sporadically observed in growing pigs. This condition is characterized by a thoracic and/or lumbar spinal deformity ... [more ▼]

Lordosis and/or kyphosis, also called ”dipped shoulder” or ”humpy‐back” is sporadically observed in growing pigs. This condition is characterized by a thoracic and/or lumbar spinal deformity. Pathomorphologically, it may be comparable with Scheuermann’s kyphosis in man and so constitutes a spontaneous model for this humane kyphosis of the thoracic or thoracolumbar spine. In pigs, this condition may decrease the value of carcasses, making deboning efforts challenging. Three major and non‐exclusive hypotheses formulated to explain these back deformations are nutrition, intrauterine viral infection and inherited predisposition. The objective of the present study was to test the latter and, if possible, to identify a locus (some loci) associated with the affection. Forty‐eight pigs were included in this case‐control study. Based on a clinical examination and/or on a measure of the degree of spinal deformity, 25 pigs classified as affected were compared to 23 pigs considered as normal. A whole genome Single Nucleotide Polymorphism (SNP) analysis was performed using a 50,000 SNP array. DNA from forty‐seven samples (tail tissue or blood) was extracted while one sample was eliminated because of its poor quality. After applying quality controls, 40 pigs and 57,838 SNPs (on a total of 62,163) remained for further analysis. One SNP (ASGA0090747) located on Sus scrofa chromosome SSC8 crossed the genome‐wide significant threshold and is thus suspected of being associated with the lordosis and/or kyphosis phenotype. These results seem to confirm the hereditary hypothesis. Further investigations are however needed to confirm the suspected association. [less ▲]

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See detailExperimental nonlinear identification of an aircraft with bolted connections
De Filippis, Giovanni; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

Aircraft structures are known to be prone to nonlinear phenomena, especially as they constantly become lighter and hence more flexible. One specific challenge that is regularly encountered is the modeling ... [more ▼]

Aircraft structures are known to be prone to nonlinear phenomena, especially as they constantly become lighter and hence more flexible. One specific challenge that is regularly encountered is the modeling of the mounting interfaces between aircraft subcomponents. Indeed, for large amplitudes of vibration, such interfaces may loosen and, in turn, trigger complex mechanisms such as friction and clearances. In this context, the present work intends to investigate the nonlinear dynamics of the Morane–Saulnier Paris aircraft, accessible at ONERA. This aircraft possesses multiple bolted connections between two external fuel tanks and wing tips. The objective of the paper is specifically to carry out an adequate identification of the numerous nonlinearities affecting the dynamics of this full-scale structure. Nonlinearity detection and the subsequent subspace-based parameter estimation have been performed on experimental data, collected during an on-ground test campaign. Nonlinearity detection is first achieved by the comparison of frequency response functions estimated at low excitation level, with those obtained at high amplitude level, yielding insight towards accurately characterizing the behavior of the bolted connections. Then, a nonlinear subspace identification method is applied to measured data to estimate the linear and nonlinear parameters of the structure and novel strategies and tools that overcome specific arisen problems are developed. [less ▲]

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See detailEarly detection of university students in potential difficulty
Hoffait, Anne-Sophie ULg; Schyns, Michael ULg

Conference (2015, February)

Rate of success in the first year at University in Belgium is very low regarding other foreign universities. The University of Liege, as other Universities, has already taken different initiatives. But by ... [more ▼]

Rate of success in the first year at University in Belgium is very low regarding other foreign universities. The University of Liege, as other Universities, has already taken different initiatives. But by early identifying students who have a high probability to face difficulties if nothing is done, the Universities might develop adapted methods to attack the problem with more emphasis where it is more needed and when it is still possible. Thus we want to develop a decision tool able to identify these students to help them. For that, we consider three standard datamining methods: logistic regression, artificial neural networks and decision trees and focus on early detection, i.e. before starting at the University. Then, we suggest to adapt these three methods as well as the classification framework in order to increase the probability of correct identification of the students. In our approach, we do not restrict the classification to two extreme classes, e.g. failure or success, but we create subcategories for different levels of confidence: high risk of failure, risk of failure, expected success or high probability of success. The algorithms are modified accordingly and to give more weight to the class that really matters. Note that this approach remains valid for any other classification problems for which the focus is on some extreme classes; e.g. fraud detection, credit default... Finally, simulations are conducted to measure the performances of the three methods, with and without the suggested adaptation. We check if the factors of success/failure we can identify are similar to those reported in the literature. We also make a ``what-if sensitivity analysis''. The goal is to measure in more depth the impact of some factors and the impact of some solutions, e.g., a complementary training or a reorientation. [less ▲]

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See detailMultiplicity editing in long-range heteronuclear correlation NMR experiments: Application to natural products
Sauri, Josep; Sistare, E.; Frederich, Michel ULg et al

Poster (2015, February)

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See detailPrévalence du virus du SDRP dans les élevages porcins
Czaplicki, Guy; Thilmant, Pierre; Van Der Stede, Yves et al

Poster (2015, February)

Porcine reproductive and respiratory syndrome (PRRS) causes major economic losses in pig farms. In different parts of the world, there is growing consensus that PRRS virus (PRRSv) eradication should be ... [more ▼]

Porcine reproductive and respiratory syndrome (PRRS) causes major economic losses in pig farms. In different parts of the world, there is growing consensus that PRRS virus (PRRSv) eradication should be performed on a regional basis, particularly in low density areas of pig production. The objective of the present study was to evaluate the apparent prevalence of PRRSv in Wallonia, a low density area of pig production (0.05 pig farms/km²). A phone survey was addressed to 173 of the 276 Walloon breeding pig owners. One hundred and thirty‐two farmers answered the questionnaire and serological tests were performed in 113 herds. If no vaccination was carried out on sows or on piglets, an Elisa test was performed on 10 breeding and/or 5 feeder pig serum samples collected between November 2011 and December 2012. An individual result was considered negative if the s/p ratio was <0.4; a herd was considered positive if an s/p ratio ≥0.4 was obtained by at least one of its pigs. Globally, at herd level and at animal level, the apparent prevalences were respectively 48% (IC95%: 39 – 57%) and 32 % (IC 95%: 29 – 35%). The present study has shown that half the Walloon breeding pig farms are serologically positive for PRRSv. Such prevalence in an area of low pig production supports the project for a regional PRRS control program. [less ▲]

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See detailExperimental modal analysis of nonlinear structures using broadband data
Noël, Jean-Philippe ULg; Renson, Ludovic ULg; Grappasonni, Chiara ULg et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

The objective of the present paper is to develop a rigorous identification methodology of nonlinear normal modes (NNMs) of engineering structures. This is achieved by processing experimental measurements ... [more ▼]

The objective of the present paper is to develop a rigorous identification methodology of nonlinear normal modes (NNMs) of engineering structures. This is achieved by processing experimental measurements collected under broadband forcing. The use of such a type of forcing signal allows to excite multiple NNMs simultaneously and, in turn, to save testing time. A two-step methodology integrating nonlinear system identification and numerical continuation of periodic solutions is proposed for the extraction of the individual NNMs from broadband input and output data. It is demonstrated using a numerical cantilever beam possessing a cubic nonlinearity at its free end. The proposed methodology can be viewed as a nonlinear generalization of the phase separation techniques routinely utilized for experimental modal analysis of linear structures. The paper ends with a comparison between this new nonlinear phase separation technique and a previously-developed nonlinear phase resonance method. [less ▲]

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See detailFrequency support among asynchronous AC systems through VSCs emulating power plants
Papangelis, Lampros ULg; Guillaud, Xavier; Van Cutsem, Thierry ULg

in Proc. 11th IET Conference on AC and DC Power Transmission (2015, February)

This paper proposes a new control scheme for the Voltage Source Converters (VSCs) of a High Voltage Direct Current (HVDC) grid connecting asynchronous AC systems, so that the latter can mutually support ... [more ▼]

This paper proposes a new control scheme for the Voltage Source Converters (VSCs) of a High Voltage Direct Current (HVDC) grid connecting asynchronous AC systems, so that the latter can mutually support their frequencies after a disturbance. The scheme involves no communication between VSCs. It is activated upon detection of a significant frequency deviation, with the possibility to limit the support requested from other AC systems. It relies on an integral control enforcing the frequency droop characteristics (of classical speed governors), in addition to the voltage-droop control of VSCs. The controller is tuned to emulate the response of a power plant, while avoiding excessive transients in the HVDC system, and limiting the impact on the other AC systems. [less ▲]

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See detailRole of the progesterone receptor in the development of sexual behavior in female mice
Desroziers, Elodie ULg; Brock, Olivier; Baum, M.J. et al

Poster (2015, February)

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See detailRobust impact design of steel and composite building structures
Hoffman, Nadine; Kuhlmann, Ulrike; Demonceau, Jean-François ULg et al

in Proceeding of the IABSE Workshop - Safety, Robustness and Condition Assessments of Structures (2015, February)

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See detailConformational properties of helical foldamers under force
Willet, Nicolas ULg; Hinterdorfer, Peter; Lecommandoux, Sébastien et al

Conference (2015, February)

The aim of this study is to investigate the mechanochemical behavior of foldamers able to change their conformation is a stimuli-responsive way. Peptidic secondary structures were studied in detail by ... [more ▼]

The aim of this study is to investigate the mechanochemical behavior of foldamers able to change their conformation is a stimuli-responsive way. Peptidic secondary structures were studied in detail by atomic force microscopy (AFM) at the single-molecule level. Synthetic copolymers containing a polypeptide block were prepared by N-carboxyanhydride amino acid ring-opening polymerization. The polymer chains were grafted onto gold surfaces and their mechanochemical behavior was then studied by AFM single-molecule force spectroscopy (SMFS). The investigated polypeptide blocks were based on polyglutamate, which undergoes transitions from alpha-helix to random coil. This can be induced by external stimuli (pH, ionic strength, temperature) or simply by applying a force. The mechanically driven unfolding of the helical foldamer was characterized in detail. Stretching the folded peptide resulted in original features in the force-distance traces. Plateaus that are specific for the helical conformation were detected, quantified and discussed. Pulling-relaxing SMFS experiments were performed and led to a better understanding of the mechanically induced unfolding of an alpha-helix as a reversible phenomenon. [less ▲]

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See detailExperimental demonstration of a 3D-printed nonlinear tuned vibration absorber
Grappasonni, Chiara ULg; Habib, Giuseppe ULg; Detroux, Thibaut ULg et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

Engineering structures are designed to be lighter and more flexible, hence reducing the extent of application of linear dynamic models. Concurrently, vibration mitigation is required for enhancing the ... [more ▼]

Engineering structures are designed to be lighter and more flexible, hence reducing the extent of application of linear dynamic models. Concurrently, vibration mitigation is required for enhancing the performance, comfort or safety in real-life applications. Passive linear vibration absorbers are purpose-built, often designed using Den Hartog's equal-peak strategy. However, nonlinear systems are known to exhibit frequency-energy-dependent oscillations which linear absorbers cannot effectively damp out. In this context, the paper introduces a new nonlinear tuned vibration absorber (NLTVA) whose nonlinear functional form is tailored according to the frequency-energy dependence of the nonlinear primary structure. The NLTVA design aims at ensuring equal peaks in the nonlinear receptance function for an as large as possible range of forcing amplitudes, hence generalizing Den Hartog's method to nonlinear systems. Our focus in this study is on experimental demonstration of the NLTVA performance using a primary structure consisting of a cantilever beam with a geometrically nonlinear component at its free end. The absorber is implemented using a doubly-clamped beam fabricated thanks to 3D printing. The NLTVA performance is also compared with that of the classical linear tuned vibration absorber. [less ▲]

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See detailDépasser la situation : de la situation-limite à la personnalité borderline. Généalogie, critique et clinique d’un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

Conference (2015, January 31)

Nous souhaitons interroger ici le concept sartrien de situation à partir d’une double approche historique et psychopathologique qui semble en diagnostiquer la disparition tout aussi bien conceptuelle ... [more ▼]

Nous souhaitons interroger ici le concept sartrien de situation à partir d’une double approche historique et psychopathologique qui semble en diagnostiquer la disparition tout aussi bien conceptuelle qu’existentielle : la notion de situation, organisatrice de l’ontologie phénoménologique de Sartre et pivot de son engagement, semble s’être aujourd’hui désintégrée en tant que concept (voir ses usages pseudo-conceptuels dans les domaines de la pédagogie et du management), alors que ce qu’on appelle la « condition postmoderne », telle qu’elle s’exprime dans de nouvelles symptomatologies psychopathologiques, rend apparemment caduque, face à la fragmentation des repères de l’existence, l’exigence de penser en/la situation. Nous procèderons en trois temps. Nous ferons d’abord la généalogie du concept, dont l’application à la psyché humaine et à la représentation théâtrale de celle-ci remonte, selon Leo Spitzer, à la fin du 17ème siècle. Dans cette première section, nous insisterons en particulier sur le rapport que l’élaboration du concept de situation entretient, au début du 20ème siècle, avec l’émergence de la psychopathologie notamment chez Jaspers (« situation-limite ») et chez Minkowski (nous rappellerons à cet égard le rôle de Gabriel Marcel dans le champ philosophique français de l’entre-deux-guerres). Nous serons également attentifs à la critique méthodologique que le concept de situation permet d’adresser à la métapsychologie freudienne. Sur cette base, nous reprendrons ensuite les principales étapes chez Sartre de la prise en considération de l’homme en situation et des possibilités de dépassement de cette situation. Nous envisagerons successivement l’Esquisse d’une théorie des émotions, « Questions de méthode » et L’Idiot de la famille. Il conviendra certes de rappeler comment l’existentialisme, comme le situationnisme à sa façon, a cherché, dans le sillage du marxisme, à réaliser la philosophie et du coup à transformer le concept en vécu. Mais nous montrerons aussi, à rebours, comment l’œuvre sartrienne, confrontée aux exigences conjointes du marxisme et de la psychanalyse (cf. l’analyse des pressions familiales dans le Flaubert), a dû dépasser le cadre de la magie émotionnelle au sein duquel la notion de situation s’était d’abord élaborée. Au-delà de la « situation sartrienne » – et peut-être en la prolongeant –, la critique de Deleuze des dispositifs nous servira enfin, dans un troisième temps, de point de bascule vers la condition postmoderne et la fragmentation de la situation en tant que repère d’existence. Le sujet borderline – véritable éclat de la postmodernité – nous permettra ainsi de conclure en reprenant le propos psychopathologique maturé par l’évolution conceptuelle de la situation. Nous caractériserons l’existence borderline par une fragmentation du soi corrélée à une explosion, voire à un morcellement, des espaces de vie qui répondent à la nécessité ontologique d’une « ubiquité instantanée » dénuée de présence corporelle (comme le permettent les espaces virtuels « connectés »). [less ▲]

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See detailHDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism
Hendrick, Elodie ULg; Peixoto, Paul ULg; Polese, Catherine ULg et al

Poster (2015, January 31)

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum ... [more ▼]

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum inhibitors of these enzymes such as SAHA can inhibit tumor growth both in vitro and in vivo and are currently used as anti-cancer agents in clinic. For many years, we are investigating the specific role of individual HDAC members in cancer biology and we have recently demonstrated that specific depletion of HDAC5 using siRNA technology reduced cancer cells proliferation and survival1 The goal of this study is to further understand the molecular mechanisms of action of HDAC5 in cancer cells. Screening transcriptomic study demonstrated that HDAC5 depletion induces a down-regulation of subunits of the complex I of the mitochondrial respiratory chain (NDUFB5-NDUFA3) as well as anti-oxydant proteins (Ferritin, Metalothionein,¿) through modulation of mRNA stability. Therefore, HDAC5 depletion causes a significant increase of ROS production inducing both apoptosis and mechanisms of mitochondria quality control (mitophagy and mitobiogenesis). This HDAC5 depletion-induced mitochondrial dysfunction provokes metabolic adaptation associated with increased importance of glucose and glutamine. Indeed, interference with both glucose and glutamine supply in HDAC5-depleted cancer cells significantly increases apoptotic cell death suggesting that glucose or glutamine deprivation might be combined to HDAC5 inhibition as a therapeutic strategy to kill cancer cells. Our study demonstrated for the first time that specific HDAC5 inhibition induces metabolic reprogramming and provides insight into a valuable experimental strategy for manipulation of specific HDAC5 inhibition and glucose metabolism in therapy against cancer. 1.Peixoto, P. et al. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell death and differentiation, 2012; 1-14. Presenting author e-mail: elodie.hendrick@student.ulg.ac.be [less ▲]

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See detailActivités physiques, représentations et femmes
Cloes, Marc ULg

Conference (2015, January 31)

Il est admis internationalement que les filles et les femmes représentent un public à risque en matière de sédentarité. Cette conférence interactive vise à répondre à trois questions: (1) L’activité ... [more ▼]

Il est admis internationalement que les filles et les femmes représentent un public à risque en matière de sédentarité. Cette conférence interactive vise à répondre à trois questions: (1) L’activité physique, qu’est-ce que c’est? (2) A quoi ça sert? (3) Qu’est-ce qu’il faut faire, finalement? Au-delà de la volonté de faire vivre aux participants une expérience originale, les objectifs finaux de l'intervention consistent à permettre une prise de conscience et à proposer des pistes d’action. [less ▲]

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See detailInteractions of natural rhamnolpids produced by Pseudomonas aeruginosa with plant model membranes
Polo Lozano, Damien ULg; Nasir, Mehmet Nail ULg; Deleu, Magali ULg et al

Poster (2015, January 30)

It is well known that chemical pesticides have harmful effects on human health and environment. In this context, the interest for alternative products such as biopesticides is increasing. Among them ... [more ▼]

It is well known that chemical pesticides have harmful effects on human health and environment. In this context, the interest for alternative products such as biopesticides is increasing. Among them, elicitors act on the plants by inducing systemic resistance against diseases caused by fungal, viral, bacterial agents and insects. Rhamnolipids are surface active molecules produced mainly by various strains of the bacterium Pseudomonas aeruginosa. These secondary metabolites are composed of one to three fatty acids with various chain lengths linked through a glycosidic bond to one or two rhamnose moieties. The fatty acids are linked together through an ester bond. These molecules have shown several biological activities including plant defense stimulation. It has been suggested that this elicitor activity could be related to an interaction of rhamnolipids with the lipid bilayer of the plant plasma membrane (PPM) and lead to its destabilization, which can activate the plant defense signaling pathways. In this context, interactions of two rhamnolipids (Rha-C10-C10 and Rha-Rha-C10-C10) with biomimetic membranes of PPM such as Langmuir monolayers and multilayers were investigated using biophysical and in silico approaches. [less ▲]

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See detailBiochemical methane potential of residues of three banana varieties from Cameroon : fresh and dry peduncles
Awedem wobiwo, Florent; Happi Emaga, Thomas; Fokou, Elie et al

Poster (2015, January 30)

In Cameroon , the ratio of energy cost to standard of living for both electric and fuel energy is higher than in USA and EU. The local energy needs could be met by valorizing local wastes in an ... [more ▼]

In Cameroon , the ratio of energy cost to standard of living for both electric and fuel energy is higher than in USA and EU. The local energy needs could be met by valorizing local wastes in an environmentally and economically sustainable way. Banana and plantain plants produce significant quantities of post-harvest biomass wastes such as bulbs, pseudo stems, leaf sheaths, petioles–midribs, leaf blades, peduncles, rachis and blossoms which can be converted to methane-rich biogas by anaerobic digestion (AD). AD is a natural process of degradation of organic materials. [less ▲]

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See detailAzacytidine prevents experimental sclerodermic chronic graft-versus-host disease
Fransolet, Gilles ULg; Ehx, Grégory ULg; SOMJA, Joan ULg et al

Poster (2015, January 30)

Introduction: Graft-versus-host disease (GVHD) remains one major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Following unmanipulated peripheral-blood stem cell ... [more ▼]

Introduction: Graft-versus-host disease (GVHD) remains one major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Following unmanipulated peripheral-blood stem cell transplantation, 60% of the patients experience chronic GVHD while approximately 15% of them develop a sclerodermic form of chronic GVHD characterized by multiple organ fibrosis and loss of skin elasticity. Regulatory T cells (Tregs) play a pivotal role in the pathology of chronic GVHD by inhibiting alloreactive conventional T cells. Several studies have shown the hypomethylating agent Azacytidine (Aza) can demethylate the master transcription factor of Treg (Forkhead box protein 3 factor, FoxP3), thus promoting Treg differentiation of conventional T cells. This work investigates the impact of Aza in a classical murine model of sclerodermic chronic GVHD (B10.D2  BALB/cJ). Methods: Lethally irradiated BALB/cJ recipient mice were injected with 107 bone marrow cells + 7.107splenocytes from B10.D2 donor mice. Recipients were treated with subcutaneous injections of Aza at the dose of 0,5 or 2 mg/kg every two days from day 10 to 30 following transplantation. Mice GVHD was evaluated with five criteria (weight loss, activity, fibrosis, hair loss and mice posture; 0-1-2 points/criteria). Mice were sacrificed at a score of 8/10 (or > 20% weight loss). Results: Mice treated with Aza 0.5 mg/kg (n = 14) or 2 mg/kg (n = 17) had significant lower clinical scores compared to control ones (n = 15) after treatment. FACS analysis showed a higher proportion of Treg among CD4+ T cells in the blood of Aza 2 mg/kg mice than in control mice (P = 0.047), as well as a higher percentage of Tregs expressing the KI67 proliferative marker on the same day (P = 0.0005). Finally, analyses of the cellular blood components with Cell-dyn demonstrated that Aza 2 mg/kg treated mice were significantly lymphopenic as compared to control mice (P = 0.05). Conclusion : Aza prevented sclerodermic GVHD in this classical murine model of chronic GVHD. [less ▲]

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See detailInfluence of cover crop management on sugar beet production
Hiel, Marie-Pierre ULg; Bodson, Bernard ULg

Poster (2015, January 30)

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See detailEvaluation et gamification - Transformer un quiz de chimie en un mini-jeu
le Maire, Nathalie ULg; Fauconnier, Marie-Laure ULg; Colaux, Catherine ULg et al

Conference (2015, January 30)

Le recours à des questionnaires à choix multiples pour l’évaluation des étudiants est une pratique courante à l’université. Cette communication décrit et analyse une expérimentation contrôlée visant à ... [more ▼]

Le recours à des questionnaires à choix multiples pour l’évaluation des étudiants est une pratique courante à l’université. Cette communication décrit et analyse une expérimentation contrôlée visant à explorer les effets de la présentation d’un QCM formatif sous la forme d’un jeu. L’étude s’inscrit ainsi dans les recherches actuelles sur les avantages et les limites pédagogiques de la « gamification », à savoir la transposition des principes issus de l’univers du jeu au domaine de l’éducation (Johnson, Adams Becker, Estrada, & Freeman, 2014). La présente recherche est effectuée dans le cadre d’un doctorat dédié spécifiquement à la gamification d’évaluations formatives. L’étude repose sur la mise à disposition de plusieurs versions d’un quiz portant sur un chapitre d’un cours de chimie générale en première année d’université. Le dispositif expérimental prévoit un enrichissement graduel de la gamification selon quatre prototypes conçus après identification et extraction de schèmes visant à stimuler et maintenir la motivation et la performance dans des jeux actuels et populaires tels que Candy Crush, Angry Birds ou Hay Day. Située à l’entrée du doctorat, cette étude vise, outre la collecte de données quant à l’utilisabilité du mini-jeu proposé, à mettre en lumière ses effets sur l’état de flow dans le contexte des edugames et contribuera à la validation de la traduction française de l’échelle d’EGameFlow (Fu, Su, & Yu, 2009). [less ▲]

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See detailElicitation of the defence mechanisms at plant case of Cucumis melo
Ydjedd, Siham; Kati, D.E.; Fauconnier, Marie-Laure ULg

Poster (2015, January 30)

The judicious use of elicitors could reduce the amount of pesticide necessary to protect crops and preservation of the environment. This strategy frequently called "stimulation of natural defenses ... [more ▼]

The judicious use of elicitors could reduce the amount of pesticide necessary to protect crops and preservation of the environment. This strategy frequently called "stimulation of natural defenses" arouses more and more interest in the phytosanitary field. [less ▲]

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See detailAzacytidine augments regulatory T cells and prevents experimental xenogeneic graft-versus-host disease.
Ehx, Grégory ULg

Conference (2015, January 30)

The demethylating agent 5-azacytidine (AZA) has proven its efficiency in myeloid malignancies treatment. Recently, several studies have shown that AZA also presents an immunomodulatory activity, mainly ... [more ▼]

The demethylating agent 5-azacytidine (AZA) has proven its efficiency in myeloid malignancies treatment. Recently, several studies have shown that AZA also presents an immunomodulatory activity, mainly through the induction of regulatory T cells (Treg) differentiation from conventional T cells. Treg promotion is a promising treatment option for graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. In this way, AZA has been shown to reduce GVHD in mouse-to-mouse transplantation models. However, the impact of AZA on human GVHD remains elusive as well as its effects on human Treg and on the other T cell subsets in vivo. Here we report AZA impact on GVHD in a xeno-transplantation model of the disease and describe the overall effects of the drug on human T cells in vivo. When administered to NSG mice receiving 2.107 human PBMC intravenously, AZA successfully ameliorated both survival (p < 0.001) and GVHD score. Flow cytometry analyses showed that this improvement may be mediated through an anti-proliferative effect of AZA on human T cells while these cells presented an increased activation state. We also observed a significant decrease of Th1 and 2 differentiation, assessed by RT-qPCR and cytokines secretion assays, and a reduced production of granzyme B and perforin 1 by cytotoxic T cells. As expected, AZA dramatically augmented Treg frequency while we could also observe a promotion of their IL-2 mediated proliferation over conventional T cells. Interestingly, Th17 frequency was not affected by AZA, therefore increasing the balance Treg/Th17. Finally our data suggest that AZA-induced Treg may have an improved suppressive activity and present long-term stability in vivo. Altogether our findings suggest that AZA may be a promising treatment option for GVHD in the clinical setting. [less ▲]

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See detailLinking bees and flowers: mutualistic interaction networks to study ecosystem functioning
Uyttenbroeck, Roel ULg; Monty, Arnaud ULg

Poster (2015, January 30)

In recent years, much attention is going to pollinators, as they are important for the increasing food production while being threatened by agricultural intensification and other environmental drivers ... [more ▼]

In recent years, much attention is going to pollinators, as they are important for the increasing food production while being threatened by agricultural intensification and other environmental drivers. While honeybees (Apis mellifera L.) are generalist according to their flower preferences, wild pollinators’ flower preferences can go from generalist to very specialist. The same goes for plant species, which can be generalist or specialist in the pollinator species they need to get pollinated. The combination of a set of generalist and specialist plant species with a pollinator community consisting of generalists and specialists in a certain habitat, results in an interaction network between pollinators and the visited plant flowers. Studying this mutualistic interaction network is a time-consuming method, but can provide valuable data to calculate indicators of ecosystem functioning. One of the important conclusions that came already out of studies applying this method is that pollination systems are often more generalized than thought based on pollination syndromes. This poster will explore the method of studying mutualistic interaction networks with a focus on the sampling protocol, the indicators that can be derived from the data and their meaning. [less ▲]

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See detailInvestigating the Effects of Plant Root Exudates on PAHs Bioavailability to Soil Microorganisms in Contaminated Brownfields : Research Methodology.
Davin, Marie ULg; Lognay, Georges ULg; Fauconnier, Marie-Laure ULg et al

Poster (2015, January 30)

As a result of heavy industrial past activities, an estimated 6,000 brownfields require remediation in Wallonia. This number rises to over 3.5 million in Europe. Polycyclic Aromatic Hydrocarbons (PAHs ... [more ▼]

As a result of heavy industrial past activities, an estimated 6,000 brownfields require remediation in Wallonia. This number rises to over 3.5 million in Europe. Polycyclic Aromatic Hydrocarbons (PAHs) represent 17% of treated pollutants in Wallonia (Aldric et al., 2011). Current remediation techniques are rather expensive and technically demanding (Megharaj et al., 2011). Based on the observation that PAHs soil content decreases in the presence of plants (Cheema et al., 2010), the PhD aims at developing alternative PAHs remediation techniques in brownfields. It is articulated around three research axes. The first axis focusses on plant exudates and how they may improve PAHs bioavailability to soil microorganisms and enhance their degradation. This will be investigated by (i) characterizing several contaminated soils (physico-chemical parameters) and PAH content and factors of bioavailability, (ii) selecting a plant model and collecting root exudates, and (iii) evaluating the effects of exudates on PAHs bioavailability. The objective of the second axis is to evaluate the effects of plant exudates on PAHs degrading microorganisms by (i) comparing PAHs biodegradation in the presence/absence of exudates and (ii) assessing the potential toxic effects of exudate compounds on the microbial communities. The aim of the third axis is to study plant-pollutants interactions by (i) establishing the plant tolerance to several contamination levels and (ii) following PAHs bioavailability when facing real exudation rates, on the field. [less ▲]

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See detailNitrous oxide flux measurement with a closed chamber system : data treatment
Regaert, Donat ULg; Moureaux, Christine ULg; Heinesch, Bernard ULg et al

Poster (2015, January 30)

Nitrous oxide flux estimation from concentration measurements with a closed chamber system. Statistical data treatment to sort between relevant/irrelevant fluxes.

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See detailWildflower strips for crop protection: What do we know ? What should we know ?
Hatt, Séverin ULg; Uyttenbroeck, Roel ULg; Bodson, Bernard ULg et al

Poster (2015, January 30)

Wildflower strips (WFS) are known to support the conservation of a large diversity of insects and thus natural enemies (i.e. predators and parasitoids) that can control pests. However, the conclusions of ... [more ▼]

Wildflower strips (WFS) are known to support the conservation of a large diversity of insects and thus natural enemies (i.e. predators and parasitoids) that can control pests. However, the conclusions of studies looking at the efficiency of WFS to control pests are not unanimous. Indeed, the enhancement of pest control seems to depend on (1) the ability of flowers to attract the natural enemies at the right moment and (2) the capacity of natural enemies to migrate into the adjacent crops to attack pests. Therefore, constituting appropriate flower mixes may be an essential lever to enhance the efficiency of pest control. In this context, using functional diversity is promising. To our knowledge, few studies have tested the impact of the functional diversity of a flower mix on insect abundance and diversity and the control of pests. Through this contribution, the insect diversity and abundance found to be associated with the different kinds of WFS and management applied will be discussed, as well as the further research needed. [less ▲]

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See detailStudy of durability and the physico-mechanical properties of thermally modified wood
Ninane, Maxime; Jourez, Benoît ULg; Hebert, Jacques ULg

Poster (2015, January 30)

Heat-treated wood is a credible alternative for certain kinds of tropical timber. It is also an alternative for certain polluting wood preservatives. This study aims to determine the changes in physico ... [more ▼]

Heat-treated wood is a credible alternative for certain kinds of tropical timber. It is also an alternative for certain polluting wood preservatives. This study aims to determine the changes in physico-mechanical properties and durability of wood that is subjected to heat treatment. For this, we studied five species (oak, ash, natural beech and a variant known as steamed beech, poplar, Douglas-fir). For each species, we had fifteen reference samples and fifteen corresponding treated samples. The results show a decrease in the hygroscopicity and an increase in dimensional stability of heat-treated wood in relation to the degradation of hemicelluloses. The mechanical properties are influence variously, because heat-treated wood is stiffer but also more brittle. The modulus of elasticity increases slightly after treatment. Side hardness and compressive fracture of heat-treated wood may increase up to 30%. On the other hand, the modulus of rupture, the ability to slit and impact may decrease by 50%, 60% and 70%. The durability of heat-treated wood against wood-destroying fungi increases. However, within each species, the durability increase varies greatly. Additional tests conducted to understand this variability, suggests that the heat distribution is not homogeneous within the processing unit. Moreover, our work suggests that durability is related to the fixed carbon content and that this path would be interesting to explore in the future. [less ▲]

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See detailLangmuir film balance- A technique to study the interaction of β-cyclodextrin with cholesterol in milk fat globule membrane monolayers
Malik, Priyanka ULg; Danthine, Sabine ULg; Paul, Aman ULg et al

Poster (2015, January 30)

Milk is a natural complex system present as oil in water emulsion. The natural organisation of milk fat globules is stabilized by the presence of a natural membrane, called the milk fat globule membrane ... [more ▼]

Milk is a natural complex system present as oil in water emulsion. The natural organisation of milk fat globules is stabilized by the presence of a natural membrane, called the milk fat globule membrane (MFGM). It has tripartite structure consisting of a monolayer facing the inner triacylglycerol core and an external bilayer. This MFGM accounts for 2-6% of fat globule. The MFGM is composed of both polar lipids and proteins. Cholesterol is also present in MFGM and accounts for about 2% of MFGM. Langmuir film balance is a technique to study monolayers and is a useful tool to examine the effect of cholesterol removal on surface properties of MFGM. β-cyclodextrin has no surface activity of its own and is thus a useful tool to study the effect of cholesterol desorption on surface properties in membrane. The removal of monolayer cholesterol to the sub-phase is proportional to the area decrease of the monolayer at a constant surface pressure. Amount of cholesterol removed can also be calculated as a function of mean molecular area at a given pressure, time and temperature. Using the monolayer technique, it is possible to study the interactions between β-cyclodextrin and MFGM film as well as effect of cholesterol removal in altering the surface properties MFGM. [less ▲]

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See detailUtility of removing cholesterol from an industrial by-product- Buttermilk powder
Malik, Priyanka ULg; Danthine, Sabine ULg; Paul, Aman ULg et al

Poster (2015, January 30)

Almost 16% of milk produced in European Union is being converted to butter. Buttermilk, is a low cost by-product from butter manufacture and available in large quantities but has been considered ... [more ▼]

Almost 16% of milk produced in European Union is being converted to butter. Buttermilk, is a low cost by-product from butter manufacture and available in large quantities but has been considered invaluable for many years. When cream is churned to butter the stable oil in water emulsion is destabilized and milk fat globule membrane (MFGM) is disrupted which is released in buttermilk. Thus, over the last two decades it has gained considerable attention due to its specific composition (proteins and polar lipids) attributed towards the MFGM. In account to this composition of buttermilk powder, it finds application in food industry as a natural stabilizing and emulsifying agent. It also finds application as a source of total solids and is commercially being added upto 10% in many food products. However, it has limitation in such applications due to the presence of cholesterol (approx. 80mg/100g). Cholesterol is also an integral part of MFGM and is released into buttermilk with MFGM. The most suitable techniques to remove cholesterol from buttermilk powder are using β-cyclodextrin and cholesterol oxidase enzyme. To valorize this abundantly produced industrial by-product of butter industry and increase its application in health food industry, as well as extend its application in pharmaceutical industry and preparation of liposomes, it is important to remove cholesterol from buttermilk. [less ▲]

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Peer Reviewed
See detailGrille de correction: déclinaisons de la perception et des réalisations
Bonnet, Pierre ULg; Delvenne, Philippe ULg; Defaweux, Valérie ULg et al

Conference (2015, January 29)

Un outil disponible on-line pour la correction des questions ouvertes à réponse courte ou longue (QROC et QROL) est utilisé depuis plusieurs années au sein de l’ULg. Les copies réponse des étudiants sont ... [more ▼]

Un outil disponible on-line pour la correction des questions ouvertes à réponse courte ou longue (QROC et QROL) est utilisé depuis plusieurs années au sein de l’ULg. Les copies réponse des étudiants sont scannées et corrigées sur un écran d’ordinateur. L’enseignant fournit l’énoncé de la question et une grille de correction suivant un canevas prédéfini. La correction évalue une série de critères regroupés par 4 à l’écran. Chaque critère défini est évalué au moyen d’une échelle horizontale allant de 0 à 100% suivant que le critère n’est pas rencontré (0%) ou qu’il est totalement développé (100%) par l’étudiant. L’enseignant peut graduer cette échelle en y indiquant des repères (indices). La pondération des différents critères est définie à priori ou à posteriori. Sur cette base de travail commune, nous analysons la façon dont cette grille est utilisée pour corriger des questions relatives à des matières médicales différentes enseignées par différents professeurs : histologie, anatomie, physiologie et anatomopathologie. L’analyse fait ressortir que malgré un canevas commun, les modalités de correction sont variables ce qui témoigne de la différence existant entre les matières, les compétences évaluées et, probablement, la sensibilité des enseignants. A l’inverse, ceci démontre la souplesse de l’outil adaptable à des types d’évaluations différents. [less ▲]

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See detailFéminiser la voix
Morsomme, Dominique ULg; Remacle, Angélique ULg

Conference (2015, January 29)

Parlée ou chantée, notre voix révèle qui nous sommes. Elle participe à notre identité et véhicule nos émotions (ref. Revis. J). Dans cet exposé, nous présenterons la voix du point de vue du genre. En ... [more ▼]

Parlée ou chantée, notre voix révèle qui nous sommes. Elle participe à notre identité et véhicule nos émotions (ref. Revis. J). Dans cet exposé, nous présenterons la voix du point de vue du genre. En effet, l’Unité Logopédie de la Voix (www.logopedie-voix.be) s’intéresse entre autres à la féminisation vocale chez les personnes transidentitaires, en processus de changement de genre. Ces personnes ne s’identifiant pas au sexe et au genre qui leur ont été attribués à la naissance, elles éprouvent un désir profond de vivre comme une personne du sexe opposé à leur sexe biologique. Lors du processus de transition où ont lieu les transformations nécessaires au changement de genre, la logopédie a pour but d’améliorer la cohérence entre l’apparence de la personne et sa voix. Ainsi, notre recherche se focalise sur ce qui distingue la voix féminine de la voix masculine. Nous visons à développer des stratégies de féminisation vocale, portant sur des paramètres tels que la fréquence fondamentale de la voix (grave ou aigüe), les contours intonatifs, le niveau d’amplitude de certains formants, le débit de parole, son rythme, ou encore le vocabulaire choisi. Féminiser une voix, c’est chercher à comprendre ce qui permet d’en identifier le genre, mais également participer à la construction de l’identité de la personne à part entière. [less ▲]

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