References of "Scientific congresses and symposiums"
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See detailMassivement histologique : entre continuité et (r)évolution pédagogique. Lancement du premier Massive Open Online Course (MOOC) sur des travaux pratiques en Histologie à destination de nos étudiants mais aussi du grand public.
Multon, Sylvie ULg; Pesesse, Laurence ULg; Weatherspoon, Alodie ULg et al

Poster (2017, March)

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formation en ligne massive ouverte à tous ». Nés aux États-Unis avec un programme sur l’intelligence ... [more ▼]

L’acronyme anglophone MOOC désigne les « Massive Open Online Courses » que l’on pourrait traduire par « formation en ligne massive ouverte à tous ». Nés aux États-Unis avec un programme sur l’intelligence artificielle dispensé par l’université de Stanford, ces cours en ligne accessibles gratuitement font miroiter la possibilité d’une démocratisation maximale des savoirs. A ce titre, les MOOC bénéficient des innovations issues du Web 2.0 : ils tirent le meilleur de la rencontre entre les nouveaux usages induits par les réseaux sociaux et les apports de la pédagogique active. Ces cinq dernières années, nous avons dispensé les travaux pratiques en Histologie aux premières années d’étude de la faculté de Médecine de l’Université de Liège par une méthodologie hybride alliant les bénéfices d’un enseignement à distance et ceux de séances menées en face-à-face (Multon et al., 2015). Notre dispositif d’auto-apprentissage invite chaque année plus de 500 étudiants à parcourir plusieurs coupes d’organes digitalisées afin de découvrir les structures histologiques pointées par des balises interactives pour chaque grande famille de tissus. La mise en ligne d’un MOOC dédié aux travaux pratiques d’Histologie s’inscrit dans une suite logique de nos activités avec une volonté de donner accès à nos ressources numériques à un public plus large. « Découvrir les tissus fondamentaux du corps humain en explorant par vous même des lames histologiques au microscope », tel est le programme de notre MOOC intitulé « Introduction à l’histologie, exploration des tissus du corps humain ». Celui-ci a débuté en février 2017 et est hébergé sur la plate-forme FUN encadrée par le ministère de l’Enseignement supérieur et de la Recherche du ministère français (https://www.fun-mooc.fr/courses/ulg/108001/session01/about). Ce MOOC s’adresse à un public large : aux étudiants ou futurs étudiants dans le domaine médical, paramédical ou scientifique, aux enseignants, chercheurs, professionnels dans le secteur de la santé, décideurs dans le domaine de l’éducation ou de la santé ou simplement aux curieux désireux de comprendre à partir de quoi le corps humain est construit. Deux parcours pédagogiques permettant d’approfondir différemment la matière sont proposés pour correspondre au mieux aux objectifs ou motivations de chacun. Au travers de vidéos explicatives contenant des dessins réalisés sous vos yeux et des liens avec l’anatomie suivie d’activités interactives telles que la manipulation d’un microscope virtuel, de nombreux quiz et d’activités réalisées avec les pairs, les participants seront capables de reconnaître les différents types de cellules et tous les éléments qui les entourent afin de comprendre comment ils s’organisent entre eux pour former des tissus aux fonctions spécifiques. Une recherche est actuellement en cours sur l’étude des traces d’activités des participants au MOOC en fonction du parcours pédagogique choisi afin d’évaluer notamment l’impact des différentes composantes de l’expérience d’apprentissage. [less ▲]

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See detail2 Years outcome of patients in unresponsive wakefulness syndrome/vegetative state and minimally conscious state
Cassol, Helena ULg; LEDOUX, Didier ULg; Thibaut, Aurore ULg et al

Poster (2017, March)

INTRODUCTION: Following severe acute brain damage, patients typically evolve from coma to an unresponsive wakefulness syndrome/vegetative state (UWS/VS; wakefulness without awareness) and later to a ... [more ▼]

INTRODUCTION: Following severe acute brain damage, patients typically evolve from coma to an unresponsive wakefulness syndrome/vegetative state (UWS/VS; wakefulness without awareness) and later to a minimally conscious state (MCS; fluctuating but consistent nonreflex behaviors). MCS is subcategorized in MCS+ (i.e., command following) and MCS- (i.e., visual pursuit, localization of noxious stimulation or contingent behaviours). Reliable and consistent interactive communication and/or functional use of objects indicate the next boundary – emergence from MCS (EMCS). To date, there is still no reliable predictive model of recovery from the UWS/VS and the MCS. A better understanding of patients' outcome would help in decisions regarding patients’ care and rehabilitation, as well as end-of-life decisions. METHODS: We collected demographic information, acute care history and longitudinal follow-up of patients in UWS/VS and MCS admitted in 15 expert centers in Belgium (via the Belgian Federal Public Service Health). Patients were evaluated at 1, 3, 6, 12 and 24 months post injury with the Coma Recovery Scale-Revised and the diagnosis was based on internationally accepted criteria of UWS/VS, MCS or EMCS. Results were considered significant at p<0.001. RESULTS: 24 months follow-up was available for 476 patients including 261 diagnosed in UWS/VS (88 traumatic, 173 non-traumatic) and 215 diagnosed in MCS (80 traumatic, 135 non-traumatic) one month after the injury. Patients who were in MCS one month after the insult were more likely to recover functional communication or object use after 24 months than patients in UWS/VS. Moreover, functional recovery occurred more often in MCS+ (79%) as compared to MCS- (29%), and mortality rate was more important in MCS- patients (68%) as compared to MCS+ (21%). Comparisons within UWS/VS and MCS groups based on etiology showed that traumatic patients had a better outcome at 24 months than non-traumatic patients. Among non-traumatic patients, no difference was found between anoxic patients and patients with other etiologies regarding functional recovery. CONCLUSION: Our study highlights that the outcome is significantly better for patients who are in MCS one month post-injury as compared to patients who remain in UWS/VS at that time. Concerning MCS patients, the outcome is significantly better for patients who are MCS+ one month post-injury as compared to patients who are MCS- at that time. This study also confirms that patients with traumatic etiology have better prognosis than patients with non-traumatic causes. [less ▲]

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See detailCan science explain consciousness? Lessons from coma and related states
Martial, Charlotte ULg

Conference (2017, March)

Understanding consciousness remains one of the greatest mysteries for science to solve. How do our brains work? How can we know if some patients in coma have any consciousness left and how could we ... [more ▼]

Understanding consciousness remains one of the greatest mysteries for science to solve. How do our brains work? How can we know if some patients in coma have any consciousness left and how could we communicate with them? What are near-death experiences? What is brain death? What happens in our brains during dreaming, hypnosis or meditation? At present, nobody understands how matter (our trillions of neural connections) becomes perception and thought. We will here briefly review some neurological facts on consciousness and impaired consciousness. Thanks to recent advances in (neuroimaging) technology, the mapping of conscious perception and cognition in health (e.g., conscious waking, sleep, dreaming, hypnosis, meditation, sleepwalking and anesthesia) and in disease (e.g., coma, near-death, “vegetative” state, seizures, hallucinations etc) is providing exiting new insights into the functional neuroanatomy of human consciousness. Our perception of the outside world (sensory awareness; what we see, hear, etc.) and our awareness of an inner world (self-awareness; the little "voice" inside that "speaks" to ourselves) seemingly depend on two separate networks we could recently identify. Philosophers might argue that the subjective aspect of the mind will never be sufficiently accounted for by the objective methods of reductionistic science. We here prefer a more pragmatic approach and remain naively optimistic that technological advances might ultimately lead to an understanding of the neural substrate of human consciousness. [less ▲]

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See detailMetronomic treatments in Pediatric Neuro-Oncology, a new therapeutic alternative?
Fohn, Anaïs; Hoyoux, Claire; DRESSE, Marie-Françoise ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2017, March), 19(1), 88

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See detailINVESTIGATION DE LA QUALITE D’ANTIBIOTIQUES A BASE D'AMOXICILLINE DANS LE CADRE DE LA SURVEILLANCE DU MARCHE OFFICIEL ET PERIPHERIQUE DE QUELQUES VILLES DE LA R.D. CONGO
Kalenda Tshilombo, Nicodème ULg; Ciza Hamuli, Patient ULg; Mavungu Landu, Don Jethro ULg et al

Poster (2017, March)

Drug counterfeiting is a sad and worrisome reality, especially in developing countries where quality control is not effective and sometimes not existing at all despite political will of governments. The ... [more ▼]

Drug counterfeiting is a sad and worrisome reality, especially in developing countries where quality control is not effective and sometimes not existing at all despite political will of governments. The consequences are harmful in particular for substandard medicines that pose more threats to populations in those countries due to their direct negative impact on patients such as failure of medical treatment including development of drug resistance and even death. Socio-economic consequences and negative reputation concerning the pharmaceutical industry are also observed. Unfortunately accurate detailed data on such medicines are not easy to obtain. Most of the time available data are often estimated from case reports or studies carried out in a specific area and during a defined period.Health authorities’ in the Democratic Republic of Congo are trying to identify this scourge by set up several strategies to fight against. One of them is built on the best knowledge of drugs from several horizons through the assessment of their quality to allow appropriate measurement. In this context, we have focused our study towards amoxicillin alone and/or combined with potassium clavulanate since it is one the very used medicines in pediatric medications. The formulations are powder for suspension. Two analytical methods were developed based on the USP monography, applying isocratic liquid chromatography. Prior to their application in routine, we evaluated the suitability of these methods through validation applying the accuracy profile of total error. Since it was planned to transfer the methods to DRC, several operating factors were taken into account namely operator, day and equipment. Interesting results were obtained in terms of trueness (relative biases below than 2.3%), precision (RSD of Intermediate precision below 2.8%), accuracy (beta-expectation tolerance intervals between -6.0% and 3.8%) for the concentration levels of interest. The latter were able to allow monitoring the quality of the two active ingredients here above in the 65 samples from Congolese market. They were collected in Kinshasa, Lubumbashi, Matadi and Kolwezi at official and non-official medicines distributors, in peripheral area. The dramatic results obtained confirm that substandard and counterfeit medicines remain a crucial problem on public health in low-income countries. Appropriate measures are really needed to set up the drug quality improvement. [less ▲]

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See detailComplementary biophysical tools to investigate lipid specificity in the interaction between bioactive peptides and the plasma membrane
Deleu, Magali ULg; Lins, Laurence ULg

Conference (2017, March)

Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic ... [more ▼]

Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic structures. The interactions between bioactive molecules notably peptides, and lipids are important for numerous processes, from drug bioavailability to viral fusion. The cell membrane is a carefully balanced environment and any changes inflicted upon its structure by a bioactive peptide must be considered in conjunction with the overall effect that this may have on the function and integrity of the membrane. As a general concept, understanding the mechanism at the molecular level by which bioactive molecules interact with cell membranes is of fundamental importance. Lipid specificity is a key factor for the detailed understanding of the penetration and/or activity of lipid-interacting peptides and of mechanisms of some diseases. Further investigation in that way should improve drug discovery and development of membrane-active molecules in many domains such as health, plant protection or microbiology. In this talk, we propose to overview some complementary “in vitro” and “in silico” biophysical approaches that can give information about lipid specificity at a molecular point of view. Our strategy is illustrated on different bioactive peptides such as antimicrobial peptides, peptides involved in human diseases or in plant cell signalling. [less ▲]

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See detailAging and Recollection: a context story
Folville, Adrien ULg; Bastin, Christine ULg; Willems, Sylvie ULg

Poster (2017, March)

Although aging is related to decline in recollection as measured by so-called objective measures, older adults’ subjective experience of recollection remains sometimes stable. Such dissociation could ... [more ▼]

Although aging is related to decline in recollection as measured by so-called objective measures, older adults’ subjective experience of recollection remains sometimes stable. Such dissociation could suggest that younger and older adults use details with different diagnosticity to make subjective recollection judgments. However, the type of details that are reported as bases for recollective experiences by younger adults can also vary as a function of context. Here, we directly investigated age-related changes in recollection and familiarity in different memorability context. Participants studied one set of words in a medium level of processing (LOP) task, and another set of words with either a shallow or deep LOP task (i.e., low vs. high memorability context, respectively). At test, participants discriminated between old and new words and provided information about the basis of their recollective experiences. In both age groups, medium items received more recollection judgments in low (vs. high) memorability context. These recollections seem to be associated with internal information (thought, image, emotion). In contrast, external details (list source, appearance, list position) more often accompanied recollection of medium items in high (vs. low) memorability context. We discuss this effect in terms of Gruppuso et al.’s (1997) functional account. Like younger adults, what older adults deem to be an experience of remembering arises from the functional utility of the recollected information for accomplishing the task. In the low (vs. high) memorability context, the information recollected for medium items more easily met the functional definition of remembering established by participants during the test. [less ▲]

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See detailNear-death experiences: recent findings
Martial, Charlotte ULg

Conference (2017, March)

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See detailMicro-mechanical testing of magnesium based composites reinforced by carbon fibers manufactured by friction stir processing
Simar, Aude; Ryelandt, Sophie; Delannay, Francis et al

Conference (2017, February 28)

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been ... [more ▼]

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been optimized to ensure a good fiber distribution. 3D X-ray tomography reveals that the fibers orient like onion rings. Thermal treatments have allowed to modify the flow stress level of the matrix material. Tensile testing inside the scanning electron microscope have revealed the decohesion at the fiber/matrix interface if the fibers are preferentially oriented perpendicularly to the loading direction. Modelling allows to estimate the stress needed to initiate this decohesion is about 250 MPa, i.e. appearing early in heat treated samples. To compare with different loading conditions, micro-compression and instrumented micro-indentation testing have also been performed. The consequence of the loading path on the decohesion is discussed. [less ▲]

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See detailOptimized integration of heat storage into district heating networks fed by a biomass CHP plant.
Sartor, Kevin ULg

in Proceedings (2017, February 28)

Biomass Combined Heat and Power (CHP) plants connected to district heating networks (DHN) are recognized as a very good opportunity to increase the share of renewable sources into energy systems. However ... [more ▼]

Biomass Combined Heat and Power (CHP) plants connected to district heating networks (DHN) are recognized as a very good opportunity to increase the share of renewable sources into energy systems. However, as CHP plants are not optimized for electricity production, their operation is profitable only if a sufficient heat demand is available throughout the year. On the other hand, these plants often work for baseline operation and back-up boilers are used to supply the peak demand. To extend the use of the CHP plants and reduce costs, conventional fuel use and emissions, it is proposed to study the feasibility of using additional high temperature heat storage as retrofit of an existing CHP plant. This work is based on a simple and effective methodology that provides accurate estimations of economic, environmental and energetic performances of CHP plants connected to district heating networks. The DHN of the University in Liège (Belgium) is used as an application framework to demonstrate the effectiveness of the selected approach. The potential energy and pollutant emissions savings and resulting energy costs are estimated and the current policy limitations will be discussed. [less ▲]

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See detailCarbon dioxide evasion from the Seine River: Drivers analysis and spatiotemporal reconstruction
Marescaux, A; Thieu, v; Borges, Alberto ULg et al

Conference (2017, February 26)

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See detailThermal comfort models for net zero energy buildings in hot climates
Belkhouane, Hamza ULg; Hensen, Jan; Attia, Shady ULg

in Second International Conference on Energy and Indoor Environment for Hot Climates (2017, February 26)

Several energy efficiency concepts and comfort models emerged in the last 15 years seeking high performance buildings and optimal occupant comfort conditions. The aim of high performance buildings is to ... [more ▼]

Several energy efficiency concepts and comfort models emerged in the last 15 years seeking high performance buildings and optimal occupant comfort conditions. The aim of high performance buildings is to reduce the carbon footprint and energy consumption of buildings while maintain a fit to purpose comfort. In this context, this work raises the question of fir to purpose comfort models that can from one side reduce the energy consumption of typical office buildings in hot climates (cooling dominated) while on the other side ensuring indoor thermal comfort. Indeed, studies that address energy efficiency are many, however it is in most cases applied to temperate or cold climates and barely explored for hot climates. The objective of this paper is to (1) combine several comfort models for a net zero energy building in hot climates, (2) select the comfort model that shows the optimal comfort quality of indoor environment and (3) compare the building's annual energy consumption for each used comfort model. To respond to our research problems, a methodology has been established, which goes through several phases. First identifying the different comfort models comfortable to use in hot climates (ISO 7730 / EN 15251 / adaptive ASHRAE / Givoni), secondly selecting a typical validated office building model as a reference building and finally selecting representative cities in the Mediterranean arid and hot climate (Algiers / Sicily / Cairo / Dubai). The study used building performance simulation to generate the different results on the energy consumption and the operative temperatures of the different models of comfort in each city. The paper ultimately identifies the fit to purpose comfort models for a medium size net zero energy office building in hot climates. The paper presents a comparison that can help building professional to identify the most appropriate comfort model that allows optimizing energy consumption, ensuring thermal comfort for robust perfromnce of net zero energy buildings in hot climates. [less ▲]

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See detailMethylglyoxal-induced carbonyl stress: perspectives of a new anti-GBM therapy
Nokin, Marie-Julie ULg

Conference (2017, February 24)

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See detailL’imprimerie à Bruxelles sous les archiducs Albert et Isabelle (1598-1633)
Adam, Renaud ULg

Conference (2017, February 23)

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See detail10. 1. Impact de la gestion des résidus de cultures sur la fertilité des sols et la production agricole
Hiel, Marie-Pierre ULg; Barbieux, Sophie ULg; Pierreux, Jérome ULg et al

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2017, February 22)

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See detailDécoder les verrous d’apprentissage d’une discipline
Verpoorten, Dominique ULg; Devyver, Julie ULg; Duchâteau, Dominique ULg et al

Conference (2017, February 21)

L’ULg a conduit une expérience pilote avec quelques enseignants. Elle vise à estimer le potentiel didactique et pédagogique d’un travail sur les « verrous d’apprentissage » (traduction délibérément ... [more ▼]

L’ULg a conduit une expérience pilote avec quelques enseignants. Elle vise à estimer le potentiel didactique et pédagogique d’un travail sur les « verrous d’apprentissage » (traduction délibérément adaptée de « bottleneck ») pour lutter contre l’échec, ou plutôt pour relever le défi de l’intégration intellectuelle du plus grand nombre. [less ▲]

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See detailAncient Egyptian philology: The digital turn. Current projects and future perspectives for the study of Ancient Egyptian texts
Polis, Stéphane ULg; Razanajao, Vincent ULg

Conference (2017, February 21)

Use of Information Technologies in Egyptology can be traced back to the early 1960s, when first efforts were made in documenting Meroitic scripts or emblematic corpora such as the Pyramid Texts. With the ... [more ▼]

Use of Information Technologies in Egyptology can be traced back to the early 1960s, when first efforts were made in documenting Meroitic scripts or emblematic corpora such as the Pyramid Texts. With the rise of the Digital Humanities in the mid-2000s, many new academic projects that implement IT solutions not only as a way to manage and present data, but also to produce, process and analyse the material, have come to light in the field. The aim of this paper is to give a survey of current digital projects related to the study of ancient Egyptian and Coptic texts. Our goal is not to be exhaustive, but to discuss the methods and tools that are being used and to describe the variety of scholarly practices. The first set of projects to be examined are those related to digital text editions and annotated corpora (including the types of representation format). Second, the question of how to handle the complex writing systems of Ancient Egypt will be addressed by looking at projects that focus on encoding (Manuel de Codage vs Unicode), on establishing hieroglyphic sign-lists (the Thot-Sign-List), on palaeographical databases and on ways to OCRize original texts efficiently. The issue of interoperability and data sharing will then be investigated through a presentation of several related projects working on a XML/TEI interchange format as well as on digital resources for enabling a Linked Open Data approach to the ancient Egyptian written material (http://thot.philo.ulg.ac.be/). Finally, we will argue in favour of a coherent data model so that encoding of data and metadata is done in the most effective way. [less ▲]

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See detailA Raster SOLAP Designed for the Emergency Services of Brussels Agglomeration
Kasprzyk, Jean-Paul ULg; Donnay, Jean-Paul ULg

in CLOUD COMPUTING 2017 - The Eighth International Conference on Cloud Computing, GRIDs, and Virtualization (2017, February 20)

In order to quickly reach incident locations, emergency services have to fairly distribute their resources on the territory. This distribution is based on an analysis which depends on heterogeneous ... [more ▼]

In order to quickly reach incident locations, emergency services have to fairly distribute their resources on the territory. This distribution is based on an analysis which depends on heterogeneous spatial data like past interventions (recurring risk), specific geographical places (sporadic risk), road network or socio-economic variables. On the other hand, Spatial Online Analytical Processing (SOLAP) tools are designed for the collection and the analysis of large spatial data sets. In this study, an original raster SOLAP model is implemented for emergency services of Brussels agglomeration. It allows decision-makers to freely generate risk maps (continuous fields), depending on several dimensions (time, intervention type, risk type, etc.), and to compare them with the accessibility of firefighters and ambulances. Simulations can also be performed on resources locations to see their impact on the main accessibility. [less ▲]

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See detailHTA et cholestérol : prise en charge intégrée - Cas cliniques
Krzesinski, Jean-Marie ULg

Conference (2017, February 18)

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See detailLevinas et les limites de la phénoménologie
Boccaccini, Federico ULg

Conference (2017, February 17)

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See detailLe remembrement-relotissement en Wallonie et aux Pays-Bas : est-il possible de réveiller la Belle Endormie ?
Dethier, Perrine ULg; Halleux, Jean-Marie ULg

Conference (2017, February 17)

Le dispositif du remembrement-relotissement, aussi appelé « Association Foncière Urbaine » en France, est un outil foncier qui permet de réaménager le maillage parcellaire et les espaces publics. Il a ... [more ▼]

Le dispositif du remembrement-relotissement, aussi appelé « Association Foncière Urbaine » en France, est un outil foncier qui permet de réaménager le maillage parcellaire et les espaces publics. Il a pour finalité de matérialiser un projet urbain et il est associé au transfert à une structure de copropriété des droits de propriété relatifs aux terrains nécessaires à la réalisation du projet en question. Il revient ensuite à cette structure de copropriété de gérer le développement du périmètre. À l’issue de l’aménagement, les propriétaires sont rétribués proportionnellement à la valeur de leurs apports fonciers respectifs. Le remembrement-relotissement est considérée comme une « Belle endormie » de l’aménagement . En effet, alors que ce dispositif présente de nombreux avantages (mobilisation du foncier à faible coût, développement de projets intégrés…), il n’est que très rarement appliqué sur le terrain . C’est dans ce cadre que se situe notre proposition, dont l’objectif est de chercher à comprendre les raisons qui limitent l’usage de cette procédure ainsi que les leviers susceptibles d’enfin banaliser sa pratique. Notre intervention sera structurée en trois parties. En première partie, nous développerons les résultats d’une analyse ayant cherché à comprendre la non-utilisation du dispositif au sein du contexte wallon . Ce travail a mis en avant que le remembrement-relotissement souffre d’une mauvaise image auprès des experts wallons de l’aménagement du territoire. Le problème fondamental réside dans la faible faisabilité liée à l’incapacité de mobiliser de concert un nombre suffisamment élevé de propriétaires. La seconde partie de notre intervention sera consacrée à la situation néerlandaise. Aux Pays-Bas, le remembrement-relotissement n’est pas non plus un outil fréquemment utilisé, ce qui s’explique par la tradition de production foncière publique. En effet, il est inutile de chercher à travailler avec les propriétaires lorsque les collectivités locales sont directement à la manœuvre pour mettre en place les projets de développement. Pour autant, en raison de la crise du modèle néerlandais de la production foncière publique, le remembrement-relotissement est aujourd’hui considéré par les autorités néerlandaises comme un outil très important afin de continuer à contrôler les montages opérationnels tout en limitant l’implication financière des collectivités. Il ressort de la comparaison entre les Pays-Bas et le Wallonie que le différentiel de confiance entre acteurs est une explication fondamentale de l’opposition entre les deux contextes. Dans ce cadre, la troisième partie de notre intervention rendra compte d’une recherche en cours qui vise à objectiver l’impact des cultures d’aménagement sur les montages opérationnels. Ce projet, qui s’appuie sur le champ de l’économie comportementale , vise en particulier à traiter des thématiques de l’aversion face aux risques et de l’importance de la confiance dans le développement des partenariats et des coopérations. [less ▲]

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See detailÉtudier un genre littéraire en Égypte Ancienne : approche(s) et méthode
Motte, Aurore ULg

Conference (2017, February 16)

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See detailStuttered and non-stuttered disfluencies in normally fluent, French-speaking preschool children
Leclercq, Anne-Lise ULg; Moyse, Astrid

Conference (2017, February 16)

The criterion of 3% of stuttered disfluencies – (part-)word repetitions, sound prolongations and blocks – is often suggested to diagnose the stuttering in children (e.g., Boey et al., 2007; Yairi ... [more ▼]

The criterion of 3% of stuttered disfluencies – (part-)word repetitions, sound prolongations and blocks – is often suggested to diagnose the stuttering in children (e.g., Boey et al., 2007; Yairi & Ambrose, 2005). There is a long-lasting debate among scholars about the relevance of considering monosyllabic word repetitions as stuttered disfluencies, given their high frequency in typically developing children (e.g., Howell, 2013; Wingate, 2001). Yet, these are the prime characteristics that prompt identification of early stuttering by parents (Yairi & Ambrose, 2013). Nevertheless, very few normative data exist concerning the disfluencies occurring in the speech of normally fluent children (Tumanova et al., 2014), and none exist in French. The aim of this study is to examine the need for reference data in French in order to distinguish typical developmental disfluency from stuttering. We used the CHAT transcription system and the coding conventions of FluencyBank to transcribe and analyse the speech disfluencies of twenty monolingual, French speaking children who do not stutter, aged 4 years. FluencyBank (Bernstein-Ratner & MacWhinney) is a shared database for the study of the development of fluency in both normal and disordered populations. It is a project of Talkbank that seeks to archive and facilitate sharing of data relevant to fluency research. [less ▲]

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See detailImpact of poplar trees on the soil water dynamics of a maize field in West-Flanders
Coussement, Tom; Janssens, Pieter; Elsen, Annemie et al

Conference (2017, February 15)

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See detailMulti-evaporator air-conditioning system
Gillet, Thomas ULg; Lemort, Vincent ULg; Andres, Emmanuelle et al

Conference (2017, February 14)

Regulation in terms of greenhouse gas emissions becomes more and more stringent and the fuel consumption targets decrease. In order to meet these demands, vehicle electrification has increased over the ... [more ▼]

Regulation in terms of greenhouse gas emissions becomes more and more stringent and the fuel consumption targets decrease. In order to meet these demands, vehicle electrification has increased over the last decade. With the arrival of plug-in hybrids and battery electric vehicles, efficient battery cooling system becomes a necessity and has to be integrated into the vehicle thermal management. One of the possibility is to integrate a chiller in the air conditioning system for extreme operating points. Moreover, this kind of system can be dedicated to luxury or large passenger cars for which a secondary evaporator is present to guarantee the comfort for rear passengers. The main challenge of this air-conditioning architecture is to maintain simultaneously the cabin thermal comfort via one or two evaporators on one hand and to maintain the battery cells in an ideal temperature range on the other hand. [less ▲]

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See detailBest Practices for NZEB design in Mixed & Cooling Dominated Climates
Attia, Shady ULg

in HARPUTLUGİL, Timuçin (Ed.) Symposium for Improving Energy Efficiency in Buildings Project (2017, February 14)

High performance buildings including net zero energy buildings (NZEB) are facing difficulty to become market mainstream in warm and hot climates. Beside the economic there are serious technical and design ... [more ▼]

High performance buildings including net zero energy buildings (NZEB) are facing difficulty to become market mainstream in warm and hot climates. Beside the economic there are serious technical and design challenges that hampers design teams design, construct and operate NZEB in mixed and cooling dominated climates. There is a difficulty to make the Passive House standard cross the heating dominated climatic zones in Northern and Central Europe to get implemented in mixed or cooling dominated climates as an ultra-energy efficient building concept. There is a need for setting new climate adaptive energy efficiency target metrics for NZEBs in warm and hot climates. This paper presents guidance and recommendations on the necessary performance target metrics for NZEBs and makes them explicit. Results are based on cross analysis of several case studies, presenting an overview of challenges and providing recommendations based on available empirical evidence to further lower those barriers Worldwide with a focus on the European construction sector. By defining the performance thresholds for NZEBs including the metrics we offer design team the possibility of verification and design assessment during early design decision making phases to instil a kind of practical, evidence based and quantifiable guidance for high performance buildings and in particular NZEBs. [less ▲]

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See detailImplication for the use of benthic foraminifera as bio-indicators of pollution: The case study of the Northern coast of Sfax (South eastern Tunisia)
Lamourou, Ali ULg; Touir, Jamel; Fagel, Nathalie ULg

in YNHM 4TH YOUNG NATURAL HISTORY SCIENTISTS' MEETING (2017, February 12)

The use of foraminifers as bioindicators of pollution in coastal and paralic environments has undergone a very fast development. Among various criteria, morphological anomalies are sometimes considered as ... [more ▼]

The use of foraminifers as bioindicators of pollution in coastal and paralic environments has undergone a very fast development. Among various criteria, morphological anomalies are sometimes considered as pollution indicators. This paper presents a synthesis of the studies correlating foraminiferal assemblages and environmental concerns. Sediment cores retrieved along the northern coast of Sfax (Tunisia) are used to monitor the response of benthic foraminifera to modern pollution and environmental stress. Sediment samples were separated immediately after collection for benthic foraminifera analysis. Binocular microscope and the Scanning Electron Microscope (SEM) were carried out to identify the most significant, normal or deformed, specimens. All observations confirmed that foraminifera may be used as indicators of pollution after deconvoluting from natural impacts. The most sensitive foraminifera identified in the study area are Ammonia tepida, Ammonia beccarii, Elphidium crispum, Peneroplis pertususles Miliolidae, Peneroplis pertusus et Rosalina sp and Peneroplis planatus. The morphological study of benthic foraminifera from surface sediments attests for the pollution of the actual coast. This pollution is recorded in the benthic foraminifera tests mainly as shell deformations, chambers or streaks or abnormal colors. [less ▲]

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See detailTen years of pedagogical training sessions for faculties teaching freshmen
Leduc, Laurent ULg; Verpoorten, Dominique ULg

Conference (2017, February 12)

Created at the University of Liège (Belgium) in 2006, the CDS - IFRES offers to all the new faculties and teaching assistants the opportunity to participate to a pedagogical training program dealing with ... [more ▼]

Created at the University of Liège (Belgium) in 2006, the CDS - IFRES offers to all the new faculties and teaching assistants the opportunity to participate to a pedagogical training program dealing with a wide range of themes exclusively related to the enhancement of teaching activities for first-year students. More than 1400 staffs have already attended to those sessions in which dissemination of good practices in the first-year course takes a large part. Leading a reflective analysis of the process of this program and its outcomes through various data, this communication offers great insights for conceptors of faculty training programs. [less ▲]

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See detailSur les traces de Madame Maes Maes-Jelinek. Les études postcoloniales : inauguration d’une tradition liégeoise.
Belleflamme, Valérie-Anne ULg; Mascoli, Giulia ULg

Conference (2017, February 11)

Pour célébrer le bicentenaire de l’Université de Liège, nous souhaitons mettre en lumière le rayonnement international de l’un des premiers centres de recherche en Europe à s’être consacré aux « ... [more ▼]

Pour célébrer le bicentenaire de l’Université de Liège, nous souhaitons mettre en lumière le rayonnement international de l’un des premiers centres de recherche en Europe à s’être consacré aux « Commonwealth studies », le CEREP (Centre d’Enseignement et de Recherche en Etudes Postcoloniales). Fondé en 1968 par la Professeure Hena Maes-Jalinek sous l’acronyme CEREC (Centre d’Enseignement et de Recherche en Etudes du Commonwealth), le CEREP fut relancé en 2006 et met désormais en exergue la dimension postcoloniale, changeant ainsi son acronyme en CEREP. Nous comptons présenter, par ailleurs, quatre auteurs phares du paysage postcolonial qui se sont vus décerner l’insigne de Docteur honoris causa par l’ULg, à savoir, Salman Rushdie, Wilson Harris, Caryl Phillips et Paul Gilroy, pour lesquels le CEREP a joué un rôle important lors de leur accueil et présentation à l’Ulg. [less ▲]

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See detailL’étude des cultures populaires à l’Université de Liège
Delbouille, Julie ULg; Guesse, Carole ULg; Dupont, Bruno ULg et al

Conference (2017, February 10)

La présente communication se propose de retracer l’implantation progressive des cultures populaires comme objet de recherche à l’Université de Liège. Du colloque de Cerisy consacré à la paralittérature en ... [more ▼]

La présente communication se propose de retracer l’implantation progressive des cultures populaires comme objet de recherche à l’Université de Liège. Du colloque de Cerisy consacré à la paralittérature en 1967 à l’ouverture d’une mineure consacrée à la culture populaire en 2014, en passant par le développement des études en bande dessinée (avec le groupe ACME), en paralittérature, en littérature jeunesse et en jeu vidéo (avec le récent Liège GameLab), la prise en considération de ces œuvres souvent jugées illégitimes ou indignes comporte, aujourd’hui encore, d’importants enjeux scientifiques, politiques et idéologiques. À travers l’étude d’objets et de pratiques longtemps déclassés par les élites, c’est en effet la définition de l’art en tant qu’institution qui est questionnée. [less ▲]

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See detailDe Grimm à Storm. La littérature allemande à l'Université de Liège
Leyh, Valérie ULg

Conference (2017, February 10)

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See detailProteomic differential distribution of 53BP1 in serrated and conventional adenomas validated by histological characterisation
QUESADA-CALVO, Florence ULg; Merli, Angela-Maria ULg; MASSOT, Charlotte ULg et al

Poster (2017, February 10)

INTRODUCTION: Sessile serrated adenoma/polyp (SSA/p) is a precancerous lesion, mostly located in the right side of the colon (cecum, ascending and transverse colon). The difficulty is to visualize this ... [more ▼]

INTRODUCTION: Sessile serrated adenoma/polyp (SSA/p) is a precancerous lesion, mostly located in the right side of the colon (cecum, ascending and transverse colon). The difficulty is to visualize this lesion during colonoscopy because of its subtle appearance. MATERIAL AND METHOD: We compared proteomes of serrated polyps (SSA/p) and conventional adenomas using residual human formalin fixed paraffin embedded (FFPE) samples. FFPE-FASP method was applied on samples before label free proteomic analysis. Immunohistochemistry (IHC) characterisation of one candidate marker was performed for tissue validation on an independent set of samples including: conventional adenomas (low and high-grade dysplasia), serrated polyps (hyperplastic polyps, SSA/p and traditional serrated adenoma) and finally normal colon (taken at the margin of colorectal cancer (CRC) or of diverticular disease). RESULTS: Proteomics provided 765 proteins (out of 5992 proteins identified) significantly discriminating conventional adenomas from serrated lesions. We selected 53BP1 (Tumor suppressor p53-binding protein 1) among these for IHC validation, because of its tumor suppressor gene function and role as a mediator of DNA damage checkpoint. 53BP1 appeared significantly up-regulated in proteomes of low and high grade adenomas compared to these of normal tissue and SSA/p. 53BP1 IHC signal was located in the nucleus and the percentage of positive nucleus decreased in serrated polyps, especially in crypts and in the border epithelium, confirming part of the proteomic results. CONCLUSION: This study highlights potential marker proteins, including 53BP1 from which IHC signal was strongly decreased in some serrated polyps. The loss of 53BP1 has been associated with tumour progression and poor prognosis, while little is currently known about its involvement in precancerous CRC lesions. 53BP1 decrease of expression in the nucleus and therefore possible loss of function in some epithelial cells could reflect important changes occurring during dysplasia to neoplasia progression in serrated lesions. [less ▲]

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See detailDialoguer avec le Tiers paysage.
Hamers, Jérémy ULg

Conference (2017, February 10)

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Peer Reviewed
See detailNon-visual effect of light on cognitive brain function: Impact of lens yellowing in aging
Daneault, Véronique; Dumont, Marie; Massé, Eric et al

Poster (2017, February 10)

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See detailLes chemins de Delbœuf
Rizzo, Rémy ULg

Conference (2017, February 09)

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See detailCharles de Méan et sa portée mémorielle
Lagasse, Benoît ULg

Conference (2017, February 09)

La présente présentation contient, d'une part, une courte biographie de Charles de Méan, juriste liégeois du 17e siècle et, d'autre part, trois exemples de sa portée mémorielle.

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See detailMusées d'ethnographie et art contemporain
Bawin, Julie ULg

Conference (2017, February 09)

Depuis le milieu des années 2000, nombreux sont les musées d’ethnographie à avoir développé une politique d’ouverture à l’art contemporain, consacrant même dans leur programmation des espaces réservés à ... [more ▼]

Depuis le milieu des années 2000, nombreux sont les musées d’ethnographie à avoir développé une politique d’ouverture à l’art contemporain, consacrant même dans leur programmation des espaces réservés à des résidences d’artistes ou à des expositions carte blanche. C’est le cas notamment du Weltkulturen Museum de Francfort, du Musée national des cultures du monde de Göteborg en Suède, du Pitt Rivers Museum d’Oxford, du Musée de la Civilisation à Québec, du Tropenmuseum à Amsterdam ou, plus récemment encore, du Musée de Tervuren et du Musée du quai Branly à Paris. Pour comprendre ce qui s’apparente à un véritable phénomène de mode – cette ouverture à la création vivante concernant par ailleurs l’ensemble du monde muséal –, il convient de s’intéresser aux premières interventions d’artistes dans les musées d’ethnographie, lesquelles remontent au milieu des années 1980, un moment charnière dans l’histoire de ces insitutions. Sous l’impulsion des Postcolonial Studies, les musées d’ethnographie extra-occidentale entrent progressivement dans une phase de redéfinition de leur mission et dans un processus d’auto-évaluation aux conséquences plus ou moins grandes sur les dispositifs d’exposition et de réception des objets ethnographiques. En axant notre attention sur trois expositions pionnières – celles d’Eduardo Paolozzi au Museum of Mankind à Londres (1985), de Fred Wilson au Maryland Historical Society à Baltimore (1992) et de Toma Muteba Luntumbue au Musée royal de l’Afrique centrale à Tervuren (2000) –, nous voudrions non seulement comprendre le rôle joué par l’art contemporain dans le procesus de refondation et les stratégies d’exposition des musées d’ethnographie extra-occidentale, mais saisir aussi la nature à la fois féconde et ambiguë des liens tissés entre le monde des anthropologues et celui des artistes. Le célèbre article d’Hal Foster, L’artiste comme ethnographe, servira de base à nos réflexions. [less ▲]

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See detailPremiers jalons pour une histoire du plagiat à l’Université de Liège : le cas « de Reiffenberg » (1836)
Adam, Renaud ULg

Conference (2017, February 09)

Membre d’une ancienne famille noble d’origine allemande, le baron Frédéric de Reiffenberg (1795-1850) s’est distingué dans l’histoire de Belgique pour avoir été le premier à occuper le poste de ... [more ▼]

Membre d’une ancienne famille noble d’origine allemande, le baron Frédéric de Reiffenberg (1795-1850) s’est distingué dans l’histoire de Belgique pour avoir été le premier à occuper le poste de conservateur de la Bibliothèque royale de Belgique, fondée en 1837. S’il doit notamment ce poste à l’appui qu’il reçut d’amis haut placé, il convient de rappeler que la nomination à la direction de cette institution fut pour lui une belle opportunité pour quitter Liège et, plus spécifiquement, la charge de professeur d’histoire du Moyen Âge qu’il occupait à l’Université depuis le 6 décembre 1835. En effet, au cours de l’année 1836, son parcours professionnelle fut entaché d’un scandale sans précédent qui le contraint à démissionner : une accusation de plagiat formulée par l’un de ses éminents collègues, Edouard de Lavalleye (1811-1869). La présente communication sera l’occasion de revenir sur cette affaire et son traitement médiatique. [less ▲]

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See detailImportance of using Geographic Information System for extensive Middle Palaeolithic open air sites in northern France. The example of Caours (Somme, France) and Beauvais (Oise, France).
Moreau, Gwénaëlle ULg; Locht, Jean-Luc; Patou-Mathis, Marylène et al

Poster (2017, February 09)

During the middle Palaeolithic, the northern France was only occupied by Neanderthals groups. However, successions of glacial and interglacial cycles explain a complex and discontinuous settlement ... [more ▼]

During the middle Palaeolithic, the northern France was only occupied by Neanderthals groups. However, successions of glacial and interglacial cycles explain a complex and discontinuous settlement, raising complication in the study of its dynamics at a regional scale. Therefore, some aspects of Neanderthals behaviour are still mischaracterize: in most cases, the function of the site and its territorial management over the northern France have to be specified. The spatial analysis of open air sites from northern France will help us to answer those questions. However, for Middle Palaeolithic sites, we can't see systematically on the field the spatial organisation directly, we sometimes need modelization. Therefore, we started to build a spatial analysis protocol adapted to this site and applied to such sites. The sites of Caours (Somme, France) and Beauvais (Oise, France) are two open air sites that are exceptionally well preserved and displaying a large amount of faunal and lithic rests. Both are perfect candidate to apply and test the new protocol. First results proved that for each site the existence of a spatial organisation as remains concentration zones. Then, we characterize this areas – number, distribution. Finally, we were able to associate them to human activity areas like hearths, butchery or knapping areas. [less ▲]

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See detailIdentification of proteins discriminating inflammation induced dysplasia from simple inflammation in ulcerative colitis by laser capture microdissection and label free proteomics – a pilot study
Merli, Angela-Maria ULg; QUESADA-CALVO, Florence ULg; MASSOT, Charlotte ULg et al

Conference (2017, February 09)

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when ... [more ▼]

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when tissue inflammation is present. The aim of this retrospective pilot study was to highlight proteins specifically associated with inflammation induced dysplasia in UC. We performed a pilot experiment on 15 Formalin-Fixed, Paraffin-Embedded (FFPE) samples isolated from 5 cases of UC patients with a Polypoïd Pedunculated dysplasia (UC-PP). We compared the proteomes of the UC-PP, the inflammatory (UC-I) and the normal (UC-NL) tissues of each patient. We performed Laser Capture Microdissection (LCM) in order to collect only epithelial cells, avoiding inflammatory infiltrating ones. Label free proteomic analysis using a 2D-nanoUPLC coupled with a hybrid Quadrupole-Orbitrap was applied, as well as differential analysis on the paired samples. Immunohistochemistry (IHC) characterisation of one of the selected proteins of interest was used for validation. Out of 985 quantified proteins, 7 were found significantly more abundant in UC-PP compared to UC-I tissues, with 6 being only detected in UC-PP using proteomics. One of these is Solute Carrier Family 12 member 2 (SLC12A2), also known as Na-K-2Cl co-transporter 1 (NKCC1), a protein involved in ionic balance, in T-cell migration promotion and in some features involved in cancer development like proliferation, migration or invasion. IHC results obtained were in correlation with proteomic results and showed that SLC12A2 was more abundant in UC-PP tissue than in UC-I and UC-NL tissues, with a signal clearly delimiting the dysplastic region from the surrounding inflammatory tissue. This pilot experiment shows a different proteomic profile in inflammation-associated dysplasia and simple inflammation. This should be replicated using other types of dysplasia in IBD. SLC12A2 could be a potential biomarker of inflammation-associated dysplasia. [less ▲]

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See detailLab Pay(S)age: a Laboratory of Observation as an activator for Landscape Awareness Process
Baldin, Elisa ULg; Occhiuto, Rita ULg

Poster (2017, February 09)

The notion of Landscape Observatory (ELC 2000), in the work of LabVTP at the Faculty of Architecture in the University of Liège (Wallonia-BE), has been linked with the concept of Landscape Laboratory (R ... [more ▼]

The notion of Landscape Observatory (ELC 2000), in the work of LabVTP at the Faculty of Architecture in the University of Liège (Wallonia-BE), has been linked with the concept of Landscape Laboratory (R. Gustavsson) in order to enhance and underline perceptive, experiential and active dimensions of sites, responding to the Universities’ missions required by the ELC: education and sensitization. Lab Pay(s)age, as a new typology of landscape laboratory, has developed methodological tools for landscape research, based on a multi-scale and diachronic reading of the territory, where natural and artificial traces are the complementary elements to be reinterpreted and relaunched in new participative scenarios. The Meuse valley, reshaped by deep transformations, is the main topic for researches, concerning specific morphological, typological and social characters. All along the river, the scars of industries mark the territory as a land in search of new cycle of life1. The regeneration of abandoned industrial sites, as a practice of territorial recycle, is part of sustainability policies in urban planning, based on the enhancement of local resources. The Observatory Lab Pay(s)age, is intended as a structure for site-specific study and continuous fieldwork, concerning both the evolutionary processes of natural structures and the involution of built environment. Starting from these materials, many different regeneration methodologies and temporalities have been imagined. Following the logic promoted by the ELC, the work has started by monitoring some specific areas and by contacting different local representatives with the aim of collecting data and experiences to construct a shared knowledge of the places. Then the project has become an on-going tool including all phases in the regeneration process: observation, analysis, interpretation and re-launch of new hypothesis are fundamental elements to increase the public knowledge about the cultural factors characterizing the landscape discipline. Thus, the notion of « observatory » is a strategic device, monitoring the evolution of places in time through actions of dialogue and awareness raising, in order to get citizens re-acquire a consciousness of their territory. The collected qualitative data, describe the peculiar features of the sites, based on the local actors experience and knowledge. These elements are the basis for new scenarios, used as progressive steps leading the recovery process. For this reason, the « observatory » is also a « laboratory », as the experimental projects accompany the transformation of the places through intermediate phases. Understanding and accepting mutability as a character of landscape is a preliminary step towards a co-action, where the project accords with natural dynamics. Lab Pay(s)age, according to the ELC principles, is using the earliest local answers as re-launch factors for consecutive projects, taking into account the territorial temporalities as priority in transformation process. The presentation concerns the ongoing projects and obtained reactions, such as the earliest re-naturalization programs, some selected sites for monitoring activities and Phd researches on new regeneration methods using vegetation as an active element in reclamation of industrial sites. 1 Occhiuto, R. 2016. Healing the scars of industry in Liège, in Scape n.15, 2016 [less ▲]

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See detailA modified graded response model to account for guessing in multiple-choice items
Magis, David ULg

Conference (2017, February 09)

This presentation focuses on multiple-choice items without any correction or control for guessing. Most often, item responses are recoded as binary outcomes so that dichotomous logistic item response ... [more ▼]

This presentation focuses on multiple-choice items without any correction or control for guessing. Most often, item responses are recoded as binary outcomes so that dichotomous logistic item response models (such as the 2PL or 3PL models) can be used to estimate ability levels. This is however at the cost of loosing information from collapsing all distractors into a single FALSE category. Polytomous IRT models could be considered to overcome that drawback but none of the classical models are suitable to incorporate guessing into account. The purpose of this talk is to introduce a modification to the graded response model (Samejima, 1969) that can take guessing into account. The modification consists in introducing lower and upper asymptotes to the cumulative probability curves. After a brief theoretical and technical description, practical implementation using the R package mirt (Chalmers, 2012) is discussed. Primary results from a simulation study are eventually presented and compared to traditional IRT scoring methods for scoring multiple-choice items. [less ▲]

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See detailPeptidoglycan fragments separation and identification by zwitterionic hydrophilic interaction chromatography and capillary electrophoresis coupled to mass spectrometry
Boulanger, Madeleine ULg; Raymackers, Alice ULg; Delvaux, Cédric ULg et al

Poster (2017, February 08)

Bacterial peptidoglycan-derived peptides and muropeptides are soluble unique fragments acting as messengers in diverse cell-signalling events. As the bacterial peptidoglycan wall is a major target of ... [more ▼]

Bacterial peptidoglycan-derived peptides and muropeptides are soluble unique fragments acting as messengers in diverse cell-signalling events. As the bacterial peptidoglycan wall is a major target of antibiotics, bacteria have developed specific resistance mechanisms based on the detection of such fragments. In addition, the muropeptides sensing is involved in the innate immune response toward bacterial invasion and is therefore of major importance in the eukaryotes self-defence functions. In Bacillus licheniformis 749/I, the peptidoglycan dipeptide m-A2pm-D-Glu triggers beta-lactam resistance via the induction of a beta-lactamase, BlaP. This induction process relies on a complex regulation system for which the nature and the concentration of peptidoglycan fragments leading to the formation of dipeptide moiety inside the cytoplasm are unknown. In this context, the development and the validation of a reliable method to identify and quantify those cytoplasmic fragments is of major interest. Conventionally, the peptidoglycan is first digested by mutanolysin in order to generate muropeptides which are subsequently analyzed by reversed-phase liquid chromatography (RP-LC, C18). However, this technique is not effective enough to separate the peptides that, as a result, are eluted in the flow through . In this work, we developed two novel analytical separation methods, namely capillary electrophoresis (CE) and zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC) both coupled to mass spectrometry (MS), aiming at overcoming the drawbacks encountered in traditional separation techniques. Both methods show great results in the identification of peptidoglycan fragments in complex samples. CE analysis lead to muropeptides and peptides separation whereas ZIC-HILIC only retains peptides. Nevertheless, the latter has been optimized and validated for the cytoplasmic peptidoglycan peptides identification and quantification. Althogether, ZIC-HILIC-MS and CE-MS have proved to be powerful analytical tools for the identification and quantification of peptidoglycan fragments in complex matrix samples. Further optimizations are still ongoing for the analysis of muropeptides, which hopefully will lead to the identification and quantification of cytoplasmic peptidoglycan fragments composition during the Bacillus licheniformis 749/I BlaP beta-lactamase induction process. [less ▲]

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See detailLe Projet Ramsès. Explorer la langue des pharaons au XXIe siècle
Motte, Aurore ULg; Polis, Stéphane ULg

Conference (2017, February 08)

En nous appuyant sur un historique de la chaire d’égyptologie à l’ULg (depuis sa création en 1902), nous montrons comment le Projet Ramsès est venu s’inscrire au cœur des projets de recherche du service ... [more ▼]

En nous appuyant sur un historique de la chaire d’égyptologie à l’ULg (depuis sa création en 1902), nous montrons comment le Projet Ramsès est venu s’inscrire au cœur des projets de recherche du service d’égyptologie à partir de 2006. La présentation s’attache ensuite à en présenter les derniers développements et à illustrer le caractère novateur de ce projet, tant du point de vue de l’égyptologie et de la linguistique de corpus, que du point de vue — plus large — des humanités numériques. Nous décrirons enfin le réseau de recherche européen dont il participe aujourd’hui, impliquant des collaborations suivies avec différents projets d’ampleur. [less ▲]

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See detailLe latin et le grec de Michel Dubuisson : quelques réflexions sur une œuvre consacrée au bilinguisme dans l’Antiquité gréco-romaine
Ioannidopoulos, Grégory ULg

Conference (2017, February 08)

Dans son ouvrage bien connu consacré au « Latin de Polybe », M. Dubuisson s’efforça de relever de façon exhaustive les traits de langue qui trahissaient l’influence du latin chez l’historien grec. Mais au ... [more ▼]

Dans son ouvrage bien connu consacré au « Latin de Polybe », M. Dubuisson s’efforça de relever de façon exhaustive les traits de langue qui trahissaient l’influence du latin chez l’historien grec. Mais au-delà, il s’agissait également de tirer toutes les conséquences historiques des conclusions tirées de l’analyse philologique, afin de mieux comprendre l’œuvre de Polybe. M. Dubuisson fut ainsi l’un des promoteurs d’une approche plus qualitative du bilinguisme gréco-latin, approche qu’il élargit ensuite à d’autres champs d’étude. Ce faisant, il contribua à l’affinement de nos connaissances sur les rapports que Rome entretenait avec la Grèce et sa langue, et vice-versa. Et sa démarche fut féconde, tant à l’Université de Liège, où elle s’enracinait dans une tradition solide, qu’à l’extérieur. [less ▲]

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See detailIngénieries de formation innovantes - quelles place et fonctions pour NeopassSup ?
Poumay, Marianne ULg

Conference (2017, February 08)

Dans le contexte de l'enseignement supérieur et à l'occasion du lancement de la plateforme NéopassSup, cette communication abordait l'intérêt pédagogique d'un tel outil au service du développement ... [more ▼]

Dans le contexte de l'enseignement supérieur et à l'occasion du lancement de la plateforme NéopassSup, cette communication abordait l'intérêt pédagogique d'un tel outil au service du développement professionnel des enseignants du supérieur. Elle imaginait les usages possibles de l'outil, sur la base d'activités déjà en cours. Elle anticipait ensuite les facteurs de succès de ces usages et se clôturait sur quelques réflexions, soulignant notamment l'importance de l'accompagnement des enseignants dans ces démarches de formation et de développement professionnel. [less ▲]

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See detailRestauration de papyrus et techniques d'imagerie au CEDOPAL
Carlig, Nathan ULg

Conference (2017, February 08)

Si le Centre de documentation de papyrologie littéraire (CEDOPAL) de l’Université de Liège est propriétaire, depuis 1954, d’une collection de vingt papyrus, dix-neuf grecs et un copte, datés du Ier au ... [more ▼]

Si le Centre de documentation de papyrologie littéraire (CEDOPAL) de l’Université de Liège est propriétaire, depuis 1954, d’une collection de vingt papyrus, dix-neuf grecs et un copte, datés du Ier au VIIe siècle, il est également dépositaire d’une collection privée liégeoise de papyrus grecs, coptes et démotiques, actuellement en cours de restauration. Après avoir présenté le papyrus comme support d’écriture et ses caractéristiques, nous détaillerons les techniques de restauration et d’imagerie mises en œuvre lors de la restauration de la collection de papyrus du CEDOPAL et de celle de la collection privée et nous mettrons en avant les résultats obtenus et les perspectives d’analyses futures. [less ▲]

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See detailLa "Vigna Manzi" à Garaguso (Basilicate), un nouveau projet de recherche archéologique de l'Université de Liège
Cuvelier, Graham ULg

Conference (2017, February 08)

En 1916, l’archéologue Vittorio di Cicco entreprenait des fouilles sur le site de la « Vigna Manzi », à Garaguso, en Basilicate. Il y découvrit les vestiges d’un temple qui contenait encore une partie de ... [more ▼]

En 1916, l’archéologue Vittorio di Cicco entreprenait des fouilles sur le site de la « Vigna Manzi », à Garaguso, en Basilicate. Il y découvrit les vestiges d’un temple qui contenait encore une partie de son mobilier et différentes offrandes dont la statuette en marbre d’une déesse trônante accompagnée d’un tempietto. Cette découverte ramenait à la lumière un site de premier ordre pour l’étude des relations qu’entretenaient, dans ces territoires d’Italie méridionale, les populations indigènes et les Grecs des cités de Grande Grèce. Dans le courant du XXe siècle, d’autres fouilles se sont succédé dans le sanctuaire de la « Vigna Manzi » – sans grand résultat. Durant l’été 2008, l’archéologue Jean-Marc Moret a cherché à identifier l’emplacement de la fouille de Vittorio di Cicco. Ce sondage lui a permis de retrouver d’autres structures monumentales augurant une découverte d’envergure. La publication de cette entreprise a ensuite été confiée à Thomas Morard, professeur à l’Université de Liège. Dans cette perspective, une campagne de documentation a été menée durant l’automne 2016. S’en suivra la reprise de l’enquête de terrain, un nouveau projet archéologique pour l’Université de Liège [less ▲]

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See detailThe prosumers and the grid
Gautier, Axel ULg; Jacqmin, Julien ULg; poudou, jean-christophe

Conference (2017, February 07)

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See detailPassive (re)translations and active power struggles in "Book of Longing" (Leonard Cohen)
Mus, Francis ULg

Conference (2017, February 07)

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See detailComparison of two laboratory-scale ensiling methods to assess effect of reducing sugars
Herremans, Sophie ULg; Decruyenaere, Virginie; Beckers, Yves ULg et al

Poster (2017, February 07)

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See detailDesign optimization of Rankine cycle systems for waste heat recovery from passenger car engines
Lemort, Vincent ULg; Legros, Arnaud; Dumont, Olivier ULg et al

Conference (2017, February 07)

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See detailQuantification of natural estrogens in aqueous matrices as pyridine-3-sulfonyl derivatives by UHPLC-ESI-MS/MS
Glineur, Alex ULg; Ronkart, Sébastien; Nott, Kathérine et al

Conference (2017, February 07)

Natural estrogens (estrone: E1, 17-β-estradiol : E2, estriol : E3) and synthetic estrogen (17-α-ethinylestradiol: EE2) are powerful endocrine disruptors. They may have deleterious effects on aquatic ... [more ▼]

Natural estrogens (estrone: E1, 17-β-estradiol : E2, estriol : E3) and synthetic estrogen (17-α-ethinylestradiol: EE2) are powerful endocrine disruptors. They may have deleterious effects on aquatic wildlife and also humans even at extremely low concentrations. For this reason, these molecules have been included in a watch list from the European Commission regarding emerging aquatic pollutants. The maximum detection limits are set at 0.035 and 0.40 ng/L for EE2 and E1, E2 respectively. Reaching such low levels of concentration of estrogenic compounds is a challenge, even using state-of-the-art analytical methods. In this study, we developed a UHPLC-ESI-MS/MS method allowing the quantification of E1, E2, E3 and EE2 residues in aqueous matrices. Studies commonly used ESI in negative mode albeit the poor ionization efficiency of native estrogenic compounds in this mode. In this study, the molecules were derivatised using a sulfonyl chloride reagent (pyridine-3-sulfonyl, P-3-S). The resulting response in the positive mode was significantly enhanced. Similarly to other dansyl derivatives, the product ion spectra of the P-3-S derivatives indicate ions originating from the derivatization reagent moiety. Moreover, several other ions were included in the product ion spectra of the P-3-S derivatives. Their specificity was assessed by a qualitative approach implying the analysis of different types of water samples (groundwater, surface water). Some product ions were found to be noticeably better for quantification and confirmation of the analytes. The developed analytical method was validated according to the NF T90-210 norm which is suitable to assess the performances of a method in the water quality field. The limits of quantification were 0.04, 0.05, 0.10 and 0.02 ng/L in groundwater and 0.89, 0.79,4.42 and 0.29 ng/L in surface water for E1, E2, E3 and EE2 respectively. [less ▲]

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See detailLogging impact on biodiversity in Central Africa
Doucet, Jean-Louis ULg

Conference (2017, February 07)

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See detailHydraulic and wood traits of two congeneric tropical tree species in their core habitat
Gorel, Anaïs ULg; Steppe, kathy; Beeckman, Hans et al

Conference (2017, February 06)

Background: Strong niche partitioning across rainfall gradients has been identified for several tropical tree genera. The link between hydraulic and wood anatomical traits, associated with drought ... [more ▼]

Background: Strong niche partitioning across rainfall gradients has been identified for several tropical tree genera. The link between hydraulic and wood anatomical traits, associated with drought tolerance, however remains to be explored, in order to identify the mechanisms shaping the range limits of tropical tree species. Aim: In this study, we aimed to identify the differences in hydraulic and wood traits between two congeneric tree species with contrasting distributions in moist and wet tropical forests. Location: Central African moist and wet forests Methods: In the core habitat of Erythrophleum ivorense (wet forest) and of E. suaveolens (moist), we collected branches to construct vulnerability curves and measure hydraulic capacitance, and both stem and branch wood samples to link the hydraulic traits to wood anatomy. Major results: E. suaveolens, which is characteristic of drier forests, is clearly more resistant to cavitation than E. ivorense, and also possess a greater hydraulic capacitance (i.e. the capacity that species have to mitigate periods of water storage by using internally stored water). In agreement with this great drought tolerance for E. suaveolens, wood anatomy revealed a high number of small vessels associated with small intervessel pits, features minimizing cavitation risk but also reducing water transport. Main conclusions: Drought tolerance, as indicated by both hydraulic and wood traits, strongly differed between the closely related species and explained their contrasting distribution, and affinity for moist (E. ivorense) and wet (E. suaveolens) forests. However, phenotypic plasticity in hydraulic and wood traits remained to be addressed to examine the extent of water use differences between the two species. [less ▲]

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See detailHow tree architecture varies across coexisting tropical tree species and relates to functional traits?
Loubota Panzou, Grâce Jopaul ULg; Ligot, Gauthier ULg; Loumeto, Jean-Joël et al

Conference (2017, February 06)

Architecture refers to the overall shape of a tree and the spatial position of its components. Tree height determines the position in the forest canopy and access to light, while the amount and spatial ... [more ▼]

Architecture refers to the overall shape of a tree and the spatial position of its components. Tree height determines the position in the forest canopy and access to light, while the amount and spatial distribution of the foliage depend on the depth and the width of the crown. The aim of this study is to understand how tree architecture varies across coexisting tropical tree species and relates to functional traits. Forty five coexisting tree species were sampled in the semi-deciduous forests of Northern Congo. Species were classified according to ecological strategies, specifically regeneration guilds: shade bearers (27 species), non-pioneers light demanding (14 species) and pioneers (4 species). For each species, 14–72 trees (968 trees in total) were measured over a large range of diameter (10–162 cm). At the tree level, we measured the diameter (D in cm), height (H in m), crown radius (Cr in m) and crown depth (Cd in m) and crown exposure index (CEI) was visually estimated. At species level, architectural traits (Dmax, Hmax, Crmax and Cdmax), life history traits (dispersal mode, phenology and guild) and functional traits (wood density and light requirement) were obtained. We investigates the H-D, Cr-D and Cd-D allometric relationships at the tree level using linear mixed models on log-transformed data with species as a random effect on both slope and intercept. We used the multivariate analysis to quantify the relationship between architectural, functional traits and life history traits. Based on AIC, we found that the best linear mixed model was the one with two species random parameters (intercept and slope) for H-D and Cr-D allometries, while the best model for Cd-D allometry was the one with only a random intercept. Thus, our results showed a significant variation in tree allometry between coexisting species. The interspecific variation in H-D allometry was related to light requirement while Cr-D and Cd-D allometries were more related to dispersal mode and wood density, respectively. The confirmed the existence of three ecological strategies (shade bearers, non-pioneers light demanding and pioneers) in tropical forests, specifically in Central Africa. Architectural traits were the main traits that differentiate between ecological strategies. Architectural traits are therefore strong predictors of ecological strategies of coexisting tropical tree species. [less ▲]

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See detailPredicting the future of an endemic endangered Andean bird species with a niche-based-model nested into a dynamic vegetation model
Hambuckers, Alain ULg; Zuniga, Lilian; Dury, Marie ULg et al

Conference (2017, February 05)

The slopes of the Andes are recognized as supporting the highest avian diversity in the world combined with high endemism rate but also more than 20 % of threatened species. Frugivores birds, even rare ... [more ▼]

The slopes of the Andes are recognized as supporting the highest avian diversity in the world combined with high endemism rate but also more than 20 % of threatened species. Frugivores birds, even rare species, are known as major providers of seed dispersal service. In Bolivia, the large Red-fronted Macaw (Ara rubrogenys Lafresnaye, 1847) is one of the 15 endemic species of this country. Its natural habitat is mainly semi-deciduous dry forest but this habitat is most often severely degraded. Climate change is an additional threat over tropical mountain birds and this particular species, since some scenarios suggest warming as high as 7.5°C by 2080 and significant variations in the precipitation regime and available soil water. To infer the future of bird species under warming climate, many authors use niche-based models (NBM), in which they combine effects of climate variables, alone or in combination with other environmental variables. A more elaborated approach consists in also including biotic interactions, notably the availability of particular plant species. While NBM with climate variables are now considered as a standard method to predict plant species distribution under future climate, this approach fails to consider the effect of increasing CO2 concentration in air on plant physiology. Contrariwise, dynamic vegetation models (DVM) are commonly able to reproduce this effect, although the uncertainties on the CO2 are large. This study assesses the potential impact of climate change on the range of A. rubrogenys, by combining within a NBM climate variables, relief and biotic variables, i.e. plant species resource. Plant resource is computed with a DVM and a NBM to compare the methodologies and to evaluate potential effects of CO2 on plant species distribution and indirect impacts on the bird. [less ▲]

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See detailLoss of transfer RNA U34 modifying enzymes impairs hematopoietic stem and progenitor cell differentiation and function
Rosu, Adeline ULg; Bai, Qiang ULg; Ramery, Eve ULg et al

Poster (2017, February 03)

Hematopoietic stem and progenitor cells (HSPCs) require fine-tuned protein translation for their normal maintenance and function. Conserved modifications of the wobble uridine base (U34) in transfer RNAs ... [more ▼]

Hematopoietic stem and progenitor cells (HSPCs) require fine-tuned protein translation for their normal maintenance and function. Conserved modifications of the wobble uridine base (U34) in transfer RNAs catalyzed by the Elongator complex are required for optimal protein translation efficacy and fidelity, but their biological importance in mammalian stem and progenitor cells remains largely unexplored. Here, we studied the impact of loss of activity of the catalytic subunit Elp3 of Elongator on HSPC differentiation and function. Hematopoietic-cell-specific depletion of Elp3 in conditional knockout mice resulted in shortened lifespan associated with hematopoietic failure and lymphoma development. Elp3 deletion caused apoptosis of specific bone marrow multipotent progenitors and blocked differentiation of committed progenitors, resulting in blood and bone marrow pancytopenia. In contrast, Elp3-deficient hematopoietic stem cells (HSCs) expanded with age and did not exhaust throughout life, although they were defective in reconstituting hematopoiesis in competitive transplantation assays. Mechanistically, loss of Elp3 did not result in detectable alterations in global protein synthesis rates in any HSPC subset. Rather, Elp3-deficient HSPCs displayed enhanced activity of the stress integrator and apoptosis and cell cycle regulator p53. Thus, this study supports the notion that Elongator activity is required in distinct HSPC subsets to avoid aberrant p53 activation, which otherwise results in discrete loss of function phenotypes in HSCs and downstream progenitors. [less ▲]

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See detailLocutifs et énoncés non verbaux en ancien français
Mazziotta, Nicolas ULg

Conference (2017, February 02)

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See detailFormes brèves et complexité narrative : l'effet de déjà-vu dans "Southcliffe" (Warp Films, 2013)
Belloi, Livio ULg

Conference (2017, February 02)

Cette communication se penche sur la mini-série anglaise "Southcliffe" (Warp Films, 2013) et s'emploie à dégager en elle divers effets de reprise et de déjà-vu. Ces effets font ensuite l'objet d'une ... [more ▼]

Cette communication se penche sur la mini-série anglaise "Southcliffe" (Warp Films, 2013) et s'emploie à dégager en elle divers effets de reprise et de déjà-vu. Ces effets font ensuite l'objet d'une interrogation touchant à la notion de "complexité narrative" (J. Mittell). [less ▲]

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See detailCellular stress and β-lactamase BlaP induction in Bacillus licheniformis
Dauvin, Marjorie ULg; Joris, Bernard ULg

Poster (2017, February 01)

In presence of β-lactam antibiotic in its environment, B. licheniformis produces the β-lactamase BlaP, an enzyme hydrolyzing β-lactam antibiotic, conferring on the bacteria phenotypic resistance. To ... [more ▼]

In presence of β-lactam antibiotic in its environment, B. licheniformis produces the β-lactamase BlaP, an enzyme hydrolyzing β-lactam antibiotic, conferring on the bacteria phenotypic resistance. To induce BlaP, two conditions must be fulfilled. The first one is the acylation of the membrane receptor BlaR1 by the antibiotic. The second one is a cellular stress due to the presence of the antibiotic which acylate PBP1. The nature of this signal remains unknown. In this study we postulate that the extracytoplasmic function sigma factors (ECFs) σM and σX act together with the stringent response as a secondary and redundant layer of stress upon which the BlaP induction pathway relies. [less ▲]

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See detailMyoferlin, a new autophagy player in pancreatic cancer cells
Rademaker, Gilles ULg; Hennequière, Vincent ULg; Peixoto, Paul et al

Poster (2017, February 01)

Despite intensive research, Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the deadliest forms of cancer. Early-stage of the disease is clinically silent and the diagnosis of the disease is mostly ... [more ▼]

Despite intensive research, Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the deadliest forms of cancer. Early-stage of the disease is clinically silent and the diagnosis of the disease is mostly made at an advanced stage. This late diagnosis contributes to one of the lowest 5-year survival rates (<5%). Today, PDAC are treated by surgery and/or adjuvant therapy, increasing only slightly the median survival of the patients. There is therefore an urgent need to develop new effective therapies for PDAC patients. PDAC are characterized by a high autophagic activity involved in its chemoresistance. Recently, key regulatory proteins controlling the metabolic reprogramming of PDAC cells were identified. By governing both autophagic flux and lysosomal catabolism, these proteins support the efficient processing of cargo from autophagy, providing PDAC cells with access to critical sources of nutrients. Interestingly, the high autophagy level in PDAC correlates with a poor patient outcome. Myoferlin, a member of the ferlin family overexpressed at protein level in different cancer types including PDAC, is a transmembrane protein able to bound to phospholipids and described to play an important function in membrane fusion. This characteristic invited us to investigate whether myoferlin could participate to autophagy, a process involving membrane fusion. Panc-1 cell line was used as a model of PDAC basal autophagy. Myoferlin expression was silenced using interfering RNA technology. Autophagosome abundance was evaluated by LC3-II western-blot and flow cytometry. Results indicated a significant increase in autophagosome abundance 48 h after myoferlin-silencing. This increase could arise from an increase of autophagy initiation or from an inhibition of autolysosome degradation. Using autophagy inhibitors, autophagic flux was evaluated by LC3-II and p62 western-blot after myoferlin-silencing. Results suggested a blockade in the autophagic process, impairing termination and autophagosome degradation by lysosome activity. Knowing the affinity of myoferlin for phospholipids, we wonder if this protein could interact with the phosphatidylethanolamine-conjugated LC3-II protein. Proximity-ligation assay suggested a close interaction between myoferlin and LC3. These results evoke an unexplored and undescribed role for myoferlin in autophagy. Understanding the involvement of myoferlin in this rediscovered biological process could give new clues in the development of new therapeutic strategy. [less ▲]

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See detailImproved Blood Glucose Forecasting Models using Changes in Insulin Sensitivity in Intensive Care Patients
Uyttendaele, Vincent ULg; Dickson, Jennifer; Shaw, Geoff et al

Poster (2017, February 01)

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy ... [more ▼]

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy has shown improved outcomes, but have been proven difficult to repeat or achieve safely. STAR (Stochastic TARgeted) is a model-based glycaemic control protocol using a stochastic model to forecast distributions of likely future changes in insulin sensitivity (SI) based on its current value. This can be used to determine likely future blood glucose (BG) levels for a given intervention, enabling the most optimal dose selection that best overlaps a clinically defined BG target band. This study presents a novel 3D model capable to predict likely future distribution of SI using both current SI and its prior variability (%ΔSI). Methods: Metabolic data from 3 clinical ICU cohorts totalling 819 episodes and 68629 hours of treatment under STAR and SPRINT protocols are used in this study. Data triplets (%ΔSIn, SIn, SIn+1) are created and binned together in a range of %ΔSI = [-100%, 200%] and SIn = [1.0e-7, 2.1e-3] in bin sizes of %ΔSI = 10% and SIn = 0.5e-4. The 5th, 50th, and 95th percentile of SIn+1 are determined for each bin where data density is high enough (>100 triplets) and compared to the previous stochastic model. The predictive power of the two models are compared by computing median [IQR] per-patient percentage prediction of SI within the 5th-95th and 25th-75th percentile ranges of model predictions. Results: Results show the previous model is over-conservative for ~77% of the data, mainly where %ΔSI is within an absolute 25% change. The percentage change in the 90% CI width in this region is reduced by ~25-40%. Conversely, non-conservative regions are also identified, with 90% CI width increased up to ~80%. Predictive power is similar for both model (60.3% [47.8%, 71.5%] vs. 51.2 [42.9%, 59.2%] within 25th-75th and 93.6% [85.7%, 97.3%] vs. 90.7% [84.4%, 94.6%] within 5th-95th range). Conclusions: The new 3D model achieved similar predictive power as the previous model by reducing the 5th-95th percentile prediction range for 77% of the data, predominantly where SI is stable. If the conservatism of the previous model reduces risk of hypoglycaemia, it also inhibits the controller’s ability to reduce BG to the normal range by safely using more aggressive dosing. The 3D new model thus better characterises patient-specific response to insulin, and allows more optimal dosing, increasing performance and safety. [less ▲]

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See detailLe droit fiscal à l’épreuve du droit civil: étude positive et prospective de la fiscalisation des revenus de certains acteurs relevant de l’économie sociale
Garroy, Sabine ULg

Conference (2017, February 01)

Présentation en 180 secondes de l'état de la recherche doctorale

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See detailIdentification of proteins discriminating inflammation induced dysplasia from simple inflammation in ulcerative colitis by laser capture microdissection and label free proteomics – a pilot study
Merli, Angela-Maria ULg; QUESADA-CALVO, Florence ULg; MASSOT, Charlotte ULg et al

Poster (2017, February 01)

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when ... [more ▼]

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when tissue inflammation is present. The aim of this retrospective pilot study was to highlight proteins specifically associated with inflammation induced dysplasia in UC. We performed a pilot experiment on 15 Formalin-Fixed, Paraffin-Embedded (FFPE) samples isolated from 5 cases of UC patients with a Polypoïd Pedunculated dysplasia (UC-PP). We compared the proteomes of the UC-PP, the inflammatory (UC-I) and the normal (UC-NL) tissues of each patient. We performed Laser Capture Microdissection (LCM) in order to collect only epithelial cells, avoiding inflammatory infiltrating ones. Label free proteomic analysis using a 2D-nanoUPLC coupled with a hybrid Quadrupole-Orbitrap was applied, as well as differential analysis on the paired samples. Immunohistochemistry (IHC) characterisation of one of the selected proteins of interest was used for validation. Out of 985 quantified proteins, 7 were found significantly more abundant in UC-PP compared to UC-I tissues, with 6 being only detected in UC-PP using proteomics. One of these is Solute Carrier Family 12 member 2 (SLC12A2), also known as Na-K-2Cl co-transporter 1 (NKCC1), a protein involved in ionic balance, in T-cell migration promotion and in some features involved in cancer development like proliferation, migration or invasion. IHC results obtained were in correlation with proteomic results and showed that SLC12A2 was more abundant in UC-PP tissue than in UC-I and UC-NL tissues, with a signal clearly delimiting the dysplastic region from the surrounding inflammatory tissue. This pilot experiment shows a different proteomic profile in inflammation-associated dysplasia and simple inflammation. This should be replicated using other types of dysplasia in IBD. SLC12A2 could be a potential biomarker of inflammation-associated dysplasia. [less ▲]

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See detailUsing unsupervised clustering method and SNP-based information to identify fine-level population structure
Chaichoompu, Kridsadakorn ULg; Yazew, Fentaw Abegaz; Tongsima, Sissades et al

Poster (2017, February 01)

Detailed reference viewed: 25 (2 ULg)
See detailZinc, manganese and iron interaction within the frd3 Arabidopsis mutant
Scheepers, Maxime ULg; Spielmann, Julien ULg; Goormaghtigh, Erik et al

Poster (2017, February 01)

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See detailA multiscale model of the human cardiovascular system can account for the Frank-Starling effect on vascular filling therapy
Kosta, Sarah ULg; Pironet, Antoine; Negroni, Jorge et al

Poster (2017, February 01)

Detailed reference viewed: 21 (4 ULg)