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See detailVerbal short-term memory , genes and mental retardation.
Majerus, Steve ULg

Conference (2007, March 15)

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See detailLe conflit dans l'état civil : l'envers du droit chez Thomas Hobbes
Herla, Anne ULg

Conference (2007, March 15)

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See detailPeculiar hydrophobic properties of the 67-78 fragment of α-synuclein are responsible for membrane destabilization and neurotoxicity
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Dupiereux-Fettweis, Ingrid ULg et al

Poster (2007, March 14)

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ... [more ▼]

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ago, tilted peptides have been detected in two other amyloidogenic proteins : the amyloid β peptide involved in Alzheimer’s disease, and the PrP protein linked to Creuztfeldt-Jakob’s disease. Tilted peptides are short protein fragments that adopt an oblique orientation when inserted into biological membranes. Tilted peptides are able to destabilize membranes. In this study, we predicted by sequence analysis and molecular modelling that the 67-78 fragment of α-synuclein is a tilted peptide. Like most of them, the α-syn 67-78 peptide is able to induce lipid mixing and leakage of unilamellar liposomes. A mutant designed by molecular modelling to decrease the destabilizing properties of the peptide was shown to be significantly less fusogenic. The neuronal toxicity was studied using human neuroblastoma cells and we demonstrated that the α-syn 67-78 peptide induces neurotoxicity. In conclusion, we have identified a tilted peptide in α-synuclein which could be involved in the toxicity induced during amyloidogenesis of α-synuclein. [less ▲]

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See detailImpacts of vegetation changes on LGM climate
Henrot, Alexandra ULg; François, Louis ULg; Munhoven, Guy ULg

Conference (2007, March 12)

The impacts of vegetation change on the climate at the Last Glacial Maximum are investigated with the Earth System Model of Intermediate Complexity Planet Simulator and the dynamic vegetation model Caraib ... [more ▼]

The impacts of vegetation change on the climate at the Last Glacial Maximum are investigated with the Earth System Model of Intermediate Complexity Planet Simulator and the dynamic vegetation model Caraib (CARbon Assimilation in the Biosphere). [less ▲]

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See detailThe fringes of psychosis proneness: unfolding the domains of risk
Laroi, Frank ULg

Conference (2007, March 10)

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See detailPrévenir la myopathie atypique du cheval au pré par la gestion raisonnée des pâtures et des chevaux établie sur base de l'identification des facteurs de risques de la maladie
Votion, Dominique ULg; Delguste, Catherine ULg; Amory, Hélène ULg et al

in 33ème Journée de la Recherche Equine (2007, March 08)

La myopathie atypique (MA) des équidés est un syndrome de destruction musculaire massive et sévère affectant des chevaux séjournant en pâture. Cette myopathie, généralement fatale endéans les 72 heures ... [more ▼]

La myopathie atypique (MA) des équidés est un syndrome de destruction musculaire massive et sévère affectant des chevaux séjournant en pâture. Cette myopathie, généralement fatale endéans les 72 heures, est rencontrée en France de manière significative et récurrente depuis l’automne 2002. La Belgique a reconnu ses premiers cas de MA au cours de l’automne 2000. Grâce à la collecte systématique des données épidémiologiques et cliniques des cas belges confirmés par analyse histologique de muscles prélevés post mortem, il a été possible de définir les facteurs de risques contribuant à l’émergence de la maladie dans une prairie et/ ou au sein d’un élevage. A partir de ces facteurs de risques identifiés, des mesures de prévention de la MA sont proposées et discutées. [less ▲]

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See detailCalcification and transparent exopolymer particles (TEP) production in batch cultures of Emiliania huxleyi exposed to different pCO2
De Bodt, Caroline; d'Hoop, Quentin; Harlay, Jérôme ULg et al

Poster (2007, March 06)

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP ... [more ▼]

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP accumulate until the end of the experiment and are enhanced after nutrient exhaustion. TEP contribute significantly to POC concentrations after the exponential growth phase. The very good correlation between TEP and calcite concentrations suggests that the calcification acts as a potential source of TEP in coccolithophore blooms. Finally, an Ωcalcite of 3 seems to be necessary for Ehux to calcify. [less ▲]

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See detailCoccolithophorid calcium carbonate dissolution in surface waters
Harlay, Jérôme ULg; Koch, Craig; Young, Jeremy R et al

Poster (2007, March 06)

The role of calcifying organisms in the ocean biogeochemistry has been receiving increasing attention since CO2-related global change issues such as ocean acidification were pointed out by the scientific ... [more ▼]

The role of calcifying organisms in the ocean biogeochemistry has been receiving increasing attention since CO2-related global change issues such as ocean acidification were pointed out by the scientific community. The implications of changing oceanic pH in modifying ecosystems dominated by planktonic calcifiers have been shown by mesocosm and laboratory experiments based on CO2 manipulations. The major concern of such experiments focussed on variations in the rates of ecosystem primary production and calcification due to changes in algal physiology or specific composition. Our results, from an interdisciplinary survey of coccolithophore-dominated blooms in the northern Bay of Biscay (NE Atlantic), suggest that biogenic calcite dissolution is occurring in the photic zone where surface waters are oversaturated with respect to calcite. The dissolution of CaCO3 in surface waters, evidenced by scanning electron microscopy observations, has an impact on the preservation and export of carbon in coccolithophore-dominated ecosystems and on the exchange of CO2 across the ocean-atmosphere interface. Both aspects of suspended calcite concentration reduction in natural environments (lower rates of production or dissolution) could be considered as a perturbation of the oceanic carbon cycle. We aim at presenting here a biogeochemical description of processes, including integrated primary production, calcification, and parameters such as transparent exopolymer particles concentration and particulate inorganic carbon profiles, during field studies. A mechanism for calcite dissolution, based on biological activity in microenvironments (including grazing, bacterial respiration and DMS production) is presented as a conceptual model in coccolithophore blooms. [less ▲]

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See detailDiscovery of Magnetic Fields in Slowly Pulsating B Stars
Hubrig, S.; Briquet, Maryline ULg; Schöller, M. et al

in Active OB-Stars: Laboratories for Stellar and Circumstellar Physics, ASP Conference Series, Vol. 361, Proceedings of the conference held 29 August - 2 September, 2005 at Hokkai-Gakuen University, Sapporo, Japan. (2007, March 01)

We present the first observations and conclusions of a magnetic survey with FORS 1 at the VLT of a sample of 25 Slowly Pulsating B stars. A clear mean longitudinal magnetic field of the order of a few ... [more ▼]

We present the first observations and conclusions of a magnetic survey with FORS 1 at the VLT of a sample of 25 Slowly Pulsating B stars. A clear mean longitudinal magnetic field of the order of a few hundred Gauss was detected in eleven SPBs. Among them several SPBs show a magnetic field that varies in time. It becomes clear that SPBs cannot be regarded anymore as non-magnetic stars. [less ▲]

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See detailBelgian schizophrenia outcome survey (SOS)
Peuskens, J.; Gillain, B.; De Graeve, D. et al

in European Psychiatry (2007, March), 22(Suppl. 1), 132

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See detailCO2 dynamics and related air-ice-sea gas transfer in spring pack and land fast sea ice,
Delille, Bruno ULg; Schoemann, V.; Lannuzel, D. et al

Poster (2007, March)

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See detailLeast cost optimization of a large passenger vessel
Richir, Thomas; Losseau, Nicolas; Pircalabu, Eugen et al

in International Conference on “Advancements in Marine Structures”, (Proceedings of MARSTRUCT’2007), Edt Guedes Soares & Das, Publ: Taylor & Francis Group, UK, 12-14 March 2007 (2007, March)

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See detailPrevalence of vitamin D inadequacy is high in European postmenopausal women
Bruyère, Olivier ULg; Malaise, Olivier; Neuprez, Audrey ULg et al

in Osteoporosis International (2007, March), 18(Suppl.1), 124

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See detailRigid body attitude synchronization: a consensus approach
Sarlette, Alain ULg; Sepulchre, Rodolphe ULg; Leonard, Naomi

Conference (2007, March)

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See detailEffect of age on a fractal bone texture parameter assessed by high resolution digital X Ray: a multicenter pilot study
Gadois, C.; Zegels, Brigitte; Dohuu, J. P. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 102

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See detailRimonabant improves glucose tolerance in the overweight or obese non-diabetic patient: analysis of the RIO-Europe and RIO-Lipids studies
Scheen, André ULg; Despres, J. P.; Ziegler, O. et al

in Diabetes & Metabolism (2007, March), 33(Sp. Iss. 1), 68

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See detail"La prescription acquisitive immobilière"
Lecocq, Pascale ULg

in Lecocq, Pascale; Engels, Christian (Eds.) Chronique de droit à l'usage des juges de paix et de police 2007 (2007, March)

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See detailStrontium ranelate prevents spine osteoarthritis progression in patients with prevalent spinal osteoarthritis
Bruyère, Olivier ULg; Delferriere, Danielle; Roux, Christian et al

in Osteoporosis International (2007, March), 18(Suppl1), 16-17

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See detailLow incidence of osteoporosis treatment after hip fracture
Rabenda, Véronique ULg; Mertens, Raf; Fabri, Valérie et al

in Osteoporosis International (2007, March), 18(Suppl.1), 72-73

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See detailIntermittent intravenous (i.v.) ibandronate injections are more effective than an established daily oral regimen: DIVA 2-year results
Czerwinski, E.; Reginster, Jean-Yves ULg; Jonkanski, I. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 127

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See detailIntroduction and welcome
Reginster, Jean-Yves ULg

in Osteoporosis International (2007, March), 18(Suppl.1), 182-183

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See detailLe regard des intervenants et l'éventail des parents
Absil, Gaëtan ULg; Denis, Marie-Elise

Conference (2007, March)

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See detailLe sexe, élément d'appréciation du risque ?
Paris, Catherine ULg

in Rogge, Jean (Ed.) Discrimination, différenciation hommes/femmes et assurances - Discriminatie, geslachtsdifferentie en verzekeringen (2007, March)

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See detailEarly colonization of Posidonia oceanica (L.) Delile by epiphytes: Comparison between natural and artificial seagrass leaves
Pete, Dorothée ULg; Gobert, Sylvie ULg; Lepoint, Gilles ULg et al

in Pergent-Martini, Christine; El Asmi, Souha; Le Ravallec, Célia (Eds.) Proceedings of the third Mediterranean symposium on marine vegetation (2007, March)

Posidonia oceanica is an important marine Magnoliophyta of the Mediterranean coastal zone that can form dense meadows. The leaves of this seagrass are colonized by a lot of organisms, from bacteria to ... [more ▼]

Posidonia oceanica is an important marine Magnoliophyta of the Mediterranean coastal zone that can form dense meadows. The leaves of this seagrass are colonized by a lot of organisms, from bacteria to polychaetes and algae. However, the early stages of colonization are not well known. A preliminary is proposed to examine the nine first days of colonization by epiphytes on natural leaves and on Artificial Seagrass Units (ASUs). Aims of this work were to understand which species are the first to set up, to compare colonization on both leaves and to determine the interest of ASUs in ecological studies. It was shown that the setting up of epiphytes on the bases of both leaves is rapid (first algae on the second day) but the number of organisms increases quicker on ASUs than on natural leaves and on the smooth faces than the rough ones. Shannon-Wiener diversity and evenness were higher for the P. oceanica leaves and the use of Bray-Curtis similarity index showed that colonisation is not similar (between 20 and 30 % similarity) on both leaves for the same day. It can be explained by the lower colonization rate of natural leaves. This lower rate is probably due to a less developed biofilm on natural leaves than on ASUs, to a difficult access to the bases of P. oceanica leaves for epiphytes and microoganisms, and the production of phenol compounds by the plant. Even if ASUs used here do not seem to be similar to natural leaves in early stages of colonization, they could be used in ecological studies thanks to their rapid covering by epiphytes. [less ▲]

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See detailBiogeochemical cycle in a coccolithophorid bloom
Suykens, Kim; Delille, Bruno ULg; Borges, Alberto ULg

Poster (2007, March)

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See detailOral ibandronate (150 mg) continues to be effective and well tolerated when administered monthly: the mobile study long-term extension
Stakkestad, J. A.; Lorenc, R.; Czerwinski, E. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 135-136

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See detailUse of exergy to detect and measure perturbations affecting Posidonia oceanica (L.) Delile meadows: Characterization in the sedimentary compartment
Pete, Dorothée ULg; Bouquegneau, Jean-Marie ULg; Gobert, Sylvie ULg

Poster (2007, March)

Within the scope of the European Water Framework Directive, it seems important to characterize state and evolution of marine ecosystems in a global way. So, it is proposed to use both thermodynamic ... [more ▼]

Within the scope of the European Water Framework Directive, it seems important to characterize state and evolution of marine ecosystems in a global way. So, it is proposed to use both thermodynamic indicators called exergy (Ex) and specific exergy (Exsp) in Posidonia oceanica meadows. Aims of this project are to detect and measure perturbations owed to nutrients loading and mechanical spoiling in the Mediterranean coastal zone. It will be led in the Bay of Calvi, on the microbenthic loop (organic matter, bacteria, microphytobenthos and meiofauna) and will be divided in two parts: sampling in different zone of the meadow and in situ experiments. In the end of this study, it will be possible to give a diagnostic on the health of P. oceanica meadow and to determine how this health will evolve, thanks to the introduction of the exergy in a model. [less ▲]

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See detailA role for the transcriptional complex elongator in cell migration and spreading
Creppe, C.; Close, Pierre ULg; Cornez, I. et al

Poster (2007, March)

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See detailA randomized controlled trial with chondroitin sulfate involving over 600 patients: STOPP (STudy on Osteoarthritis Progression Prevention)
Kahan, A.; Vignon, E.; Uebelhart, D. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 14-15

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See detailCalcium daily food intake is very low in European postmenopausal women
Bruyère, Olivier ULg; De Cock, Caroline; Neuprez, Audrey ULg et al

in Osteoporosis International (2007, March), 18(Suppl.1), 125

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See detailStrontium ranelate decreases vertebral fracture risk whatever the level of pretreatment bone turnover markers
Collette, Julien ULg; Reginster, Jean-Yves ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2007, March), 18(Suppl.1), 127-128

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See detailSTOPP (STudy on Osteoarthritis Progression Prevention): chondroitin sulfate reduces the progression of joint space narrowing in knee OA
Reginster, Jean-Yves ULg; Vignon, E.; Uebelhart, D. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 187-188

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See detailCarbon dioxide in European coastal waters
Borges, Alberto ULg; Schiettecatte, L.-S.; Abril, G. et al

Poster (2007, March)

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See detailFirst-choice treatment for post menopausal osteoporotic patients
Reginster, Jean-Yves ULg

in Osteoporosis International (2007, March), 18(Suppl.1), 178

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See detailVitamin D inadequacy in Belgian postmenopausal women
Neuprez, Audrey ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2007, March), 18(Suppl.1), 123

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See detailTotal joint replacement after glucosamine sulfate treatment of knee osteoarthritis: results from a 8-year prospective cohort
Bruyère, Olivier ULg; Pavelka, K.; Rovati, Lucio C et al

in Osteoporosis International (2007, March), 18(Suppl.1), 81

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See detailLow dietary calcium intake in patients treated for osteoporosis
Reginster, Jean-Yves ULg; Imschoot, J.

in Osteoporosis International (2007, March), 18(Suppl.1), 132

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See detailThe role of deformation in the bouncing droplet problem
Terwagne, Denis ULg; Gilet, Tristan ULg; Dorbolo, Stéphane ULg et al

Poster (2007, March)

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See detailAdherence to bisphosphonates therapy and hip fracture risk in osteoporotic women
Rabenda, Véronique ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2007, March), 18(Suppl.1), 19-20

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See detailAnomalies of tolerance in glucose in schizophrenic patients treated with antipsychotics of second generation: 3 months prospective comparative study
Scheen, André ULg; De Hert, M.; Hanssens, L. et al

in Diabetes & Metabolism (2007, March), 33(Sp. Iss. 1), 129

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See detailRationale and development of an individual patient-based model to accurately assess the efficacy of osteoporosis management
Hiligsmann, Mickaël ULg; Richy, Florent; Ethgen, Olivier ULg et al

in Osteoporosis International (2007, March), 18(S1), 169

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See detailLa langue et le réel. Réflexions sur la motivation iconique
Polis, Stéphane ULg

Conference (2007, February 28)

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See detailImplantation des cultures
Bodson, Bernard ULg; Roisin, Christian; Vancutsem, Françoise ULg et al

in Livre Blanc: Céréales - Gembloux (2007, February 28)

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See detailQualité: Aperçu de l'année écoulée - Récolte 2006: pire, ça n'existe peut être pas!
Sinnaeve, Georges; Paridaens, A. M.; Lenartz, J. et al

in Livre Blanc: Céréales - Gembloux (2007, February 28)

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See detailLa fumure azotée
Destain, Jean-Pierre ULg; Couvreur, Luc; Herman, Jean-Luc et al

in Livre Blanc: Céréales - Gembloux (2007, February 28)

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See detailLes régulateurs de croissance
Vancutsem, Françoise ULg; Monfort, Bruno; Bodson, Bernard ULg et al

in Livre Blanc: Céréales - Gembloux (2007, February 28)

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See detailWhen Mass Spectrometry meets Spectroscopy: A Different Perspective on Ion Photodissociation
Gabelica, Valérie ULg

Conference (2007, February 27)

Photodissociation methods are more and more widely used in analytical mass spectrometry as an alternative to collision-induced dissociation. A well known example is infrared multiphoton dissociation ... [more ▼]

Photodissociation methods are more and more widely used in analytical mass spectrometry as an alternative to collision-induced dissociation. A well known example is infrared multiphoton dissociation (IRMPD) with CO2 lasers (wavelength 10.6 µm), which is often preferred to SORI-CID in FTICR mass spectrometers. IR photons are absorbed by the vibrational modes of the ion, and this vibrational energy is redistributed all over the molecule. The fragmentation channels observed are usually the same as for CID. Recently, new possibilities offered by UV lasers of fixed wavelength (i.e. 157 nm or 193 nm) for peptide fragmentation were described. On the contrary to IRMPD, irradiation at these UV wavelengths gives rise to fragmentation channels which are unprecedented in CID, suggesting that photochemical reactions take place. The prerequisite for ion photodissociation is photon absorption. In the infrared, photon absorption results in the excitation of vibrational modes. Anharmonic coupling of the excited vibrational modes with other vibrational modes of the ion results in a rapid intramolecular vibrational energy redistribution (IVR). The energy of an IR photon is too low for the ion to dissociate (0.117 eV/photon for a 10.6 µm CO2 laser). Multiple cycles of absorption and IVR are necessary for IR photodissociation to occur (hence the term multiphoton). Because the first step in photodissociation is photon absorption, the recording of the photodissociation yield as a function of the photon wavenumber gives information on the vibrational modes of the ion. This is the basic principle of infrared spectroscopy experiments inside the mass spectrometer. This technique will be illustrated by a recent example on DNA single strands and quadruplex structures. The shifting of the vibrational frequencies corresponding to guanine C=O stretch gives information on the base pairing in the DNA ion in the gas phase. The situation is somewhat different with UV photons, which may lead to either electronic excitation of the ions or direct electron ejection. Electronic excited states may evolve in different ways: (1) Internal conversion to a vibrationally excited electronic ground state. Resulting fragments would then be similar to CID and IRMPD. This process can be multiphotonic and could be coined UVMPD. (2) Electron autodetachment, leading to the formation of radicals that can be further fragmented to obtain ECD-like or EDD-like fragments. (3) Photochemical reactions giving rise to unprecedented fragmentation channels. In all three cases, product ion yield is conditioned by photon absorption by an electronic state, meaning that UV spectroscopy of gas-phase ions can be performed with a mass spectrometer. We recently explored the effects of photon absorption on multiply charged DNA anions. Depending on the photon wavelength and on the chromophores, all three situations could be observed. Electron photodetachment is the major channel observed when using wavelengths corresponding to DNA base absorption.1,2 When irradiated at proper wavelength, chromophoric DNA ligands also give rise to electron photodetachment. UV-visible spectra of the DNA duplexes and complexes were recorded and compared with solution-phase spectra. Finally, a porphyrin ligand gives rise to specific fragmentation pathways when irradiated at 450 nm, while photodetachment is observed at 260 nm. The most recent results will be presented and discussed. 1. Gabelica, V.; Tabarin, T.; Antoine, R.; Rosu, F.; Compagnon, I.; Broyer, M.; De Pauw, E.; Dugourd, P. Electron Photodetachment Dissociation of DNA Polyanions in a Quadrupole Ion Trap Mass Spectrometer. Anal. Chem. 2006, 78 (18), 6564. 2. Gabelica, V.; Rosu, F.; Tabarin, T.; Kinet, C.; Antoine, R.; Broyer, M.; De Pauw, E.; Dugourd, P. Base-Dependent Electron Photodetachment from Negatively Charged DNA Strands upon 260-nm Laser Irradiation. J. Am. Chem. Soc. 2007, accepted for publication. [less ▲]

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See detailSecondary dispersal by dung beetles of seeds primarily dispersed by tamarins
Culot, Laurence ULg

Conference (2007, February 22)

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See detailImpact des mesures judiciaires alternatives pour les consommateurs de drogues
Fincoeur, Bertrand ULg

Conference (2007, February 21)

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See detailInternational Foundation for Research in Paraplegia
Martin, Didier ULg

Conference (2007, February 20)

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See detailPREDetector : Prokaryotic Regulatory Element Detector
Hiard, Samuel ULg; Rigali, Sébastien ULg; Colson, Séverine ULg et al

Poster (2007, February 15)

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The ... [more ▼]

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The emergence of position weight matrices based programs has facilitated the access to this approach. However, a tool that automatically estimates the reliability of the predictions and would allow users to extend predictions in genomic regions generally regarded with no regulatory functions was still highly demanded. Result: Here, we introduce PREDetector, a tool developed for predicting regulons of DNA-binding proteins in prokaryotic genomes that (i) automatically predicts, scores and positions potential binding sites and their respective target genes, (ii) includes the downstream co-regulated genes, (iii) extends the predictions to coding sequences and terminator regions, (iv) saves private matrices and allows predictions in other genomes, and (v) provides an easy way to estimate the reliability of the predictions. Conclusion: We present, with PREDetector, an accurate prokaryotic regulon prediction tool that maximally answers biologists’ requests. PREDetector can be downloaded freely at http://www.montefiore.ulg.ac.be/~hiard/predetectorfr.html [less ▲]

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, February 15)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailL'emprunt linguistique comme marqueur de vitalité des langues
Baiwir, Esther ULg

Conference (2007, February 09)

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See detailThe composition of the inflammatory infiltrate in 3 cases of polyneuritis equi
Van Galen, Gaby ULg; Sandersen, Charlotte ULg; Delguste, Catherine ULg et al

in In Proccedings of the Second congress of the European College od Equine Internal Medicine (ECEIM) (2007, February 02)

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See detailThe role of deformation in the bouncing droplet problem
Terwagne, Denis ULg; Gilet, Tristan ULg; Dorbolo, Stéphane ULg et al

Poster (2007, February)

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See detail"Ethno-évaluation" : le savoir des acteurs comme théorie de l'action
Absil, Gaëtan ULg

Conference (2007, February)

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See detailTransfert d'image et hybridation post-traumatique
Hamers, Jérémy ULg

Conference (2007, February)

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See detailFirst-Principles Study of Thermal and Elastic Properties of Al2O3
Xu, Bin ULg; Dong, Jianjun

Poster (2007, February)

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See detailIronie et idéologie. Réflexions sur la responsabilité idéologique du texte
Denis, Benoît ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2007, February), (2),

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See detailBio-Climatic Chart for Different Climatic Zones of North-East India
Singh, Manoj Kumar ULg; Mahapatra, Sadhan; Atreya, S. K.

in S K, Dube; T, Muneer; G N, Tiwari (Eds.) et al Proceedings of 3rd International Conference on Solar Radiation and Day Lighting : (SOLARIS 2007) (2007, February)

This article examines and analyses the climates of Northeast India with respect to building design parameters: temperature, relative humidity, wind velocity/direction and solar radiation, with a view to ... [more ▼]

This article examines and analyses the climates of Northeast India with respect to building design parameters: temperature, relative humidity, wind velocity/direction and solar radiation, with a view to providing passive solar design potential for the achievement of physiological comfort. It presents the work on development of bio-climatic zones for the region. The major climatic types of the region are warm and humid, cool and humid and cold and cloudy zones. A bio-climatic approach is adopted in which the comfort zone and 12 monthly climatic lines are determined and plotted on the psychrometric chart for each climatic zone. From these bioclimatic charts, the potential use of passive design strategies such as solar heating, natural ventilation, thermal mass, thermal mass with night ventilation and evaporative cooling are assessed. A total of five passive design strategies are considered. It is expected that this study will help in explaining the different passive features, which are present in traditional buildings of the region and also help the architects to design modern climate responsive energy efficient buildings in the region. [less ▲]

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See detailLes discours de la cour de récréation : méthodologie, recueil, analyse
Meunier, Deborah ULg

in Actes des IXèmes Rencontres Jeunes Chercheurs de l’Ecole Doctorale 268 « Langage et langues », Université de la Sorbonne Nouvelle (2007, February)

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See detail3D image analysis characterization of dried banana
Léonard, Angélique ULg; Devahastin, Sakamon; Blacher, Silvia ULg

Conference (2007, February)

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See detailReproductibilité, faux parfaits et contrefaçons: entre fétichisme artistique et gout esthétique
Dondero, Maria Giulia ULg

in Nouveaux Actes Sémiotiques (2007, January 31)

Ce travail analyse la relation entre le jugement esthétique qui catégorise quelque chose comme Kitsch et l’authenticité et/ou la reproductibilité des objets, c’est-à-dire leur histoire de production. J’ai ... [more ▼]

Ce travail analyse la relation entre le jugement esthétique qui catégorise quelque chose comme Kitsch et l’authenticité et/ou la reproductibilité des objets, c’est-à-dire leur histoire de production. J’ai analysé les procédures de « Kitschification » et les conditions à travers lesquelles se forment et se justifient certains jugements de goût à une certaine période et dans une certaine culture. En partant de la distinction du philosophe Nelson Goodman entre « arts autographiques » et « arts allographiques » j’ai pris en considération le cas du Parthénon de Nashville, monument qui se présente comme la reconstruction du Parthénon d’Athènes, et qui apparaît comme une œuvre plus parfaite et donc plus « originale » de l’original lui-même. Cette analyse démontre que le jugement de goût ne peut pas renvoyer à la simple configuration textuelle d’un objet et donc à ses caractéristiques morphologiques, et que le jugement de goût dépend par contre de l’insertion spatio-temporelle (intertextuelle et interculturelle) de l’objet pris en considération. Dans cet article j’ai également analysé les notions d’aura (Benjamin), de patine, outre celles d’autographie et d’allographie par rapport aux arts architectural et pictural. [less ▲]

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See detailSuivi diachronique de l’analyse de corpus partagés
Bénel, Aurélien; Lejeune, Christophe ULg

Conference (2007, January 26)

Les anthropologues des sciences ont développé un mode d'inscription permettant le suivi de l'innovation qu'ils appellent "graphe socio-technique". Cette contribution présente les tentatives d'application ... [more ▼]

Les anthropologues des sciences ont développé un mode d'inscription permettant le suivi de l'innovation qu'ils appellent "graphe socio-technique". Cette contribution présente les tentatives d'application de ce dispositif de visualisation au suivi de l'activité sur des plateformes informatiques. Elle soulève des difficultés à la fois techniques et méthodologiques. [less ▲]

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