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See detailInfluence of drospirenone on renin-angiotensin-aldosterone system evaluation
VROONEN, Laurent ULg; Cavalier, Etienne ULg; Vranken, Laura ULg et al

in Endocrine Abstracts - 13th European Congress of Endocrinology (2011)

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See detailInorganic carbon in the Tana River Basin (Kenya): Distribution, composition and process rates
Van den Meersche, K.; Tamooh, F.; Meysman, F. et al

Conference (2011)

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See detailEl homenaje de 1930 a Juan Ruiz: sinécdoque y silepsis
Ceballos Viro, Alvaro ULg

in Toro Ceballos, Francisco; Godinas, Laurette (Eds.) Juan Ruiz, Arcipreste de Hita, y el "Libro de buen amor". Congreso homenaje a Jacques Joset (2011)

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See detailMolecular phylogeography of the common dormouse, Muscardinus avellanarius
Mouton, Alice ULg; Grill, Andrea; Sarà, Maurizio et al

Conference (2011)

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See detailIntroduction : "Nourrir les dieux ?"
Pirenne-Delforge, Vinciane ULg; Prescendi, Francesca

in Pirenne-Delforge, Vinciane; Prescendi, Francesca (Eds.) "Nourrir les dieux ?" Sacrifice et représentation du divin (2011)

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See detailIdentification expérimentale et recalage d'une structure au comportement élastodynamique non-linéaire
Hot, A.; Kerschen, Gaëtan ULg; Cogan, S. et al

in Actes du 20ème Congrès Francais de Mécanique (2011)

This paper studies of the COST-F3 beam experimental benchmark that exhibits a geometric non-linear behavior. The whole identification process, i.e. the non-linear behaviour detection, characterisation and ... [more ▼]

This paper studies of the COST-F3 beam experimental benchmark that exhibits a geometric non-linear behavior. The whole identification process, i.e. the non-linear behaviour detection, characterisation and the parameter estimation, is carried out using measured time and frequency responses. A finite element model is also built in order to update the non-linear parameter using the hybrid multi-harmonic balance extended constitutive relation error method. [less ▲]

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See detailRelation entre défaillances vitales précédant l'infection acquise aux soins intensifs et gravité de celle-ci
MARECHAL, Hugues; LEDOUX, Didier ULg; NYS, Monique ULg et al

in Réanimation (2011), 20(Suppl 1), 108102

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See detailEvolution of livelihood strategy and income of the households in the coastal sandy area of the Central region, Vietnam : the case of Thua Thien Hue Province during period 2003-2008
Nguyen Dang, Hao; Lebailly, Philippe ULg

Conference (2011)

Based on livelihood approach and using both livelihood strategy participatory assessment and household survey data this study mainly focus on assessment of evolution of livelihood strategy and income of ... [more ▼]

Based on livelihood approach and using both livelihood strategy participatory assessment and household survey data this study mainly focus on assessment of evolution of livelihood strategy and income of households in the Coastal Sandy Zone of Thua Thien Hue Province. Findings indicated that livelihood strategies are very dynamic and considerable difference between the wealth categories of households and among the study sites. Although agriculture –based strategy is one of the most popular among the livelihood strategies there are considerable changes. Thanks to more specialization on livestock - non-farm business – aquaculture the better-off category has increased rapidly their income during 2003-2008 period. By contrast, due to more dependence on food crop, wage work and migration, income of the poor slowly improved at the same period. These findings implicate that in the context of rural development, support policies introduced by government have positively influenced on household income, but these general policies cannot meet the development needs from various locations as well as different household categories because there is marked difference in livelihood assets, human source, landholding, financial and social capitals in particular. [less ▲]

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See detailLe Magdalénien dans le Nord-Ouest de l'Europe
Miller, Rebecca ULg; Noiret, Pierre ULg

Poster (2011)

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See detailImpact of the treatment conditions of a formic/acetic acid delignification method on chemical structure and antioxidant activity of beech wood lignin
Simon, Mathilde ULg; Vanderghem, Caroline ULg; Richel, Aurore ULg et al

Poster (2011)

The interest in lignocellulosic substrates is increasing because they are clearly identified for their high potential of development in energy and value-added molecules production. Indeed lignocellulosic ... [more ▼]

The interest in lignocellulosic substrates is increasing because they are clearly identified for their high potential of development in energy and value-added molecules production. Indeed lignocellulosic biomass constitutes a promising resource for a sustainable production of organic compounds and biobased products that could progressively replace molecules from the petrochemical industry. Until now lignocellulosic substrates were mainly used for the valorization of cellulose. Hemicelluloses and lignins were less valorized and often degraded after the process. However, due to their phenolic structure, lignins can be valorized in a lot of high-valued applications like vanillin production, replacement of petrochemical polymers, antioxidants for cosmetics and food industry, resins… In this study, a representative sample of beech wood (Fagus sylvatica L.) was collected in the region of Gaume in Belgium. Beech wood was delignified at atmospheric pressure by an organosolv process using a mixture of formic acid/acetic acid/water. The effect of cooking time and temperature was evaluated on the structure, physico-chemical properties and antioxidant activity of the lignins obtained from the black liquor after treatments. The structural and physico-chemical characteristics of the lignins were investigated with different tools like infrared spectrometry, thermogravimetric analysis, gel permeation chromatography after acetylation of lignins, NMR 1H, 13C and HSQC. The antioxidant activity was assessed by a spectrophotometric method using the α,α-diphenyl-β-picrylhydrazyl radical (DPPH). [less ▲]

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See detailL'inscription territoriale de la gestion des races animales : une recherche pluridisciplinaire
Steyaert, Patrick; Casabianca, François; Baret, Philippe et al

Conference (2011)

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See detailCrossing abilities of ALS Target-Site Resistant Black-grass (Alopecurus myosuroides HUDS.)
Maréchal, Pierre-Yves ULg; Henriet, François; Vancutsem, Françoise ULg et al

in Communications in Agricultural and Applied Biological Sciences (2011)

Black-grass crossings were conducted outdoor for two successive years in a way to determine the percentage of resistant black-grass that can be engendered in one generation, after the introduction of one ... [more ▼]

Black-grass crossings were conducted outdoor for two successive years in a way to determine the percentage of resistant black-grass that can be engendered in one generation, after the introduction of one Target-Site resistant individual. After germination, plants were genotyped and couples of resistant and susceptible individuals were formed, then planted outdoor and enclosed with a pollen-proof cloth to avoid any external pollen contamination. Seeds were collected and tested in glasshouses with herbicide spraying. DNA analyses were also performed on surviving plants to distinguish hetero- from homozygotes. The resistance level of the progeny seems to be fairly high and Mendelean distribution is generally confirmed. The offspring of self-crossings was also observed to assess the facultative autogamy ability, according to the genotype and the presence of mutant ALS alleles (position W-574). [less ▲]

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See detailDynamical Spot Evolution in HD 11753
Korhonen, H.; Hubrig, S.; Briquet, Maryline ULg et al

in Magnetic Stars. Proceedings of the International Conference, held in the Special Astrophysical Observatory of the Russian AS, August 27- September 1, 2010, Eds: I. I. Romanyuk and D. O. Kudryavtsev (2011)

Our recent studies of HD 11753, a late B-type star showing a HgMn peculiarity for the first time revealed the presence of a fast dynamical evolution of chemical spots on the surface of this chemically ... [more ▼]

Our recent studies of HD 11753, a late B-type star showing a HgMn peculiarity for the first time revealed the presence of a fast dynamical evolution of chemical spots on the surface of this chemically peculiar early-type star. These observations suggest a hitherto unknown physical process operating in stars with outer radiative envelopes. Furthermore, we have also discovered existence of magnetic fields on HgMn stars that were up to now considered non-magnetic. Here we will discuss the dynamical spot evolution in HD 11753 in detail, and also summarize our new results on the magnetic fields of the AR Aur binary system. [less ▲]

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See detailTuning methodology of nonlinear vibration absorbers coupled to nonlinear mechanical systems
Viguié, R.; Kerschen, Gaëtan ULg

in Proceedings of the ASME International Design Engineering Technical Conferences (2011)

A large body of literature exists regarding linear and nonlinear dynamic absorbers, but the vast majority of it deals with linear primary structures. However, nonlinearity is a frequent occurrence in ... [more ▼]

A large body of literature exists regarding linear and nonlinear dynamic absorbers, but the vast majority of it deals with linear primary structures. However, nonlinearity is a frequent occurrence in engineering applications. Therefore, the present paper focuses on the mitigation of vibrations of nonlinear primary systems using nonlinear dynamic absorbers. Because most existing contributions about their design rely on extensive parametric studies, which are computationally demanding, or on analytic methods, which may be limited to small-amplitude motions, this study proposes a tuning procedure which is computationally tractable and can treat strongly nonlinear regimes of motion. The proposed methodology relies on a frequency-energy based approach followed by bifurcation analysis. The results are illustrated using a one-degree-of-freedom primary system, which can, for instance, represent the vibrations of a specific mode of a multi-degree-of-freedom structure. [less ▲]

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See detailFood provisioning and agonistic behaviours in commensal long-tailed macaque (Macaca fascicularis) at Uluwatu Temple, Bali (Indonesia)
Brotcorne, Fany ULg; Huynen, Marie-Claude ULg; Wandia, I. Nengah

in American Journal of Primatology (2011), 73(S1),

Most previous research on nonhuman primates reported increased levels of agonistic behaviors associated with food provisioning by humans. To further investigate the permanence of this effect of increased ... [more ▼]

Most previous research on nonhuman primates reported increased levels of agonistic behaviors associated with food provisioning by humans. To further investigate the permanence of this effect of increased social competition in long-term commensal-living primates, we examined the immediate impact of food provisioning on agonistic behavior rates in a commensal population of long-tailed macaques (Macaca fascicularis) at Uluwatu Temple, Bali (Indonesia). We compared proportions of agonistic behaviors between various food provisioning levels defined by the absence/presence and the quantity of food provisioned. We collected data using focal and scan sampling methods during a four-month study period (June to October 2010). We performed non-parametric statistical tests (Wilcoxon Test & Friedman Test; p < .05) on a population sample of 66 individuals. Results did not show obvious impact of provisioning on agonism rates, nor increase of potential appeasement strategies such as sexual behaviours, grooming or self-directed behaviours, often associated with the presence of provisioned food. These data suggest that the long-tailed macaques at Uluwatu Temple are responding effectively to high provisioning level, that is, without increasing social competition. We hypothesize that the high spatiotemporal abundance of human food, associated with the species’ eco-behavioural flexibility and the long term story of human-macaque commensal relationships in Uluwatu may explain the absence of provisioning impact on agonistic rates. [less ▲]

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See detailThe impact of blue light on non-visual brain functions changes with age
Daneault*; Vandewalle*, Gilles ULg; Hébert, M et al

in NeuroImage (2011), 56(Suppl. 1),

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See detailExercise Pulmonary Hypertension in Asymptomatic Severe Aortic Stenosis.
Magne, Julien ULg; Donal, E; O'Connor, K et al

Conference (2011)

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See detailReal-Time Stability Assessment based on Synchrophasors
Jóhannsson, Hjörtur; Garcia-Valle, Rodrigo; Weckesser, Johannes ULg et al

in IEEE PES Trondheim PowerTech (2011)

In this paper, an overview is provided of a new method that in real-time provides an early warning for an emerging blackout that are characterized by a slowly increasing angular separation between sub ... [more ▼]

In this paper, an overview is provided of a new method that in real-time provides an early warning for an emerging blackout that are characterized by a slowly increasing angular separation between sub-groups of system generators. Such angular separation between subgroups of generators can eventually cause in very sharp decline in system voltages at intermediate locations between the two groups as the angular separation approaches 180 degree. In order to receive an early warning for the occurrence of such type of blackouts, the boundaries of the system generators aperiodic small-signal stability are suggested to be monitored. For that purpose, method for real-time assessment of aperiodic small-signal rotor angle stability is presented. The approach is based on an element-wise assessment of individual synchronous machines where the aim is to determine the maximum steady state power that each synchronous generator can inject into the system. The limits for maximum injectable power represent the boundary for aperiodic small signal stability. The concept of the proposed method is tested on two different systems. The results show that the method is capable of accurately detecting when a given machine crosses the stability boundary. The method can as well provide in real-time a margin to the machines stability boundary, which can be used as an early warning for an impending system stability problem. [less ▲]

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See detailPractical Handling, Ease of Use, Safety and Efficacy of A New Pediatric Triple-Chamber Bag for Parenteral Nutrition in Preterm Infants
rigo, J; marlowe, ML; Bonnot, D et al

in Pediatric Research (2011), 70(S5), 719

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See detailResults from the Herschel Key Program MESS
Groenewegen, M. A. T.; Waelkens, C.; Barlow, M. J. et al

in Kerschbaum, F.; Lebzelter, T.; Wing, R. F. (Eds.) Why Galaxies Care about AGB Stars II: Shining Examples and Common Inhabitants. ASPC 445 (2011)

MESS (Mass loss of Evolved StarS) is a Herschel Guaranteed Time Key Program that will image about 100, and do spectroscopy of about 50, post-main-sequence objects of all flavours: AGB stars, post-AGB ... [more ▼]

MESS (Mass loss of Evolved StarS) is a Herschel Guaranteed Time Key Program that will image about 100, and do spectroscopy of about 50, post-main-sequence objects of all flavours: AGB stars, post-AGB stars, planetary nebulae, luminous blue variables, Wolf-Rayet stars, and supernova remnants. In this review the implementation and current status of MESS is outlined, and first results are presented. [less ▲]

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See detailOptimization of a formic/acetic acid treatment of beech wood (Fagus sylvatica L.) for delignification
Simon, Mathilde ULg; Richel, Aurore ULg; Vanderghem, Caroline ULg et al

Poster (2011)

Lignin is a promising molecule constituting a renewable alternative to some petrochemical industry products. Lignin is an aromatic cross-linked heteropolymer composed of three phenylpropanoids (p ... [more ▼]

Lignin is a promising molecule constituting a renewable alternative to some petrochemical industry products. Lignin is an aromatic cross-linked heteropolymer composed of three phenylpropanoids (p-hydroxyphenyl, guaiacyl and syringyl units) linked together via radical coupling reactions by specific ether or carbon-carbon bonds. With this phenylpropanoid structure, lignin is a rich resource of biobased products that could find high-valued applications in a lot of different areas like petrochemical polymer reinforcement and replacement, antioxidants, stabilizers, resins and vanillin production... The first challenge of the valorization of lignins is their extraction from raw materials. Lignins can be found in different lignocellulosic substrates like grasses, softwood and hardwood. This extraction process needs the development of suitable biomass treatments, allowing efficient lignin recuperation without degradation. This one could lead to the loss of some interesting properties and so of some valorization possibilities. In this study, beech wood (Fagus sylvatica L.) was collected in the region of Gaume (Belgium). Beech wood particles were delignified at atmospheric pressure by a mixture of formic acid/acetic acid/water. A central composite design and response surface methodology were used for the optimization of treatment parameters for delignification. The optima of two independent variables, namely time (1h30, 3h, 4h30) and temperature (87°C, 97°C, 107°C), were determined on delignification yield, pulp yield, concentration of degradation products (furfural and hydroxymethylfurfural). Moreover, the impact of these two variables on the amount of residual linkages between phenylpropanoid units was evaluated by semi-quantitative bidimensional nuclear magnetic resonance spectroscopy (NMR-HSQC). Our results highlight that the delignification yields increase when cooking time and temperature are elevated. Nevertheless, under these conditions, pulp yield decreases as hydrolysis of hemicelluloses and cellulose occurs. The hydrolysates of carbohydrates (free sugars or oligosaccharides) are contained in the black liquor. At elevated temperature and time, the amount of degradation products in the black liquor is increased. [less ▲]

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See detailJoint Observation of Object Pose and Tactile Imprints for Online Grasp Stability Assessment
Bekiroglu, Yasemin; Detry, Renaud ULg; Kragic, Danica

Conference (2011)

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See detailOptimal multi-subject fMRI experiments
Maus, Bärbel ULg; van Breukelen, Gerard J P; Goebel, R et al

Conference (2011)

Functional magnetic resonance imaging is a neuroimaging method which is used to study the human brain and its functional areas. In multi-subject fMRI experiments, data from several subjects is collected ... [more ▼]

Functional magnetic resonance imaging is a neuroimaging method which is used to study the human brain and its functional areas. In multi-subject fMRI experiments, data from several subjects is collected while these subjects perform each the same task of interest, e.g., passive viewing of houses presented on a screen, in the scanner. In my talk optimal designs for multi-subject fMRI experiments with fixed experimental budget are considered. The optimal combination of number of subjects and fMRI scanner time/imaging time per subject will be studied. Analytical and numerical results based on a linear mixed effects model with uncorrelated and correlated errors will be presented for common parameters of fMRI experiments. It will be shown how the optimal number of subjects and optimal scanner [less ▲]

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See detailLa coccinelle asiatique est-elle l'aphidiphage dominant dans les agro-écosystèmes ?
Vandereycken, Axel ULg; Durieux, Delphine ULg; Joie, Emilie ULg et al

in 9ème Conférence Internationale sur les Ravageurs en Agriculture, Montpellier 26-27 octobre 2011 (2011)

The Asian ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), has been introduced in Western Europe to control aphid and coccid populations in greenhouses. This exotic species rapidly adapted ... [more ▼]

The Asian ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), has been introduced in Western Europe to control aphid and coccid populations in greenhouses. This exotic species rapidly adapted to temperate climatic conditions and invaded all Europe in few years. Now, H. axyridis is causing damages to the ecosystems through e.g. intraguild predation (IGP) with native species. We evaluated, in 2009 and 2010, the occurrence of aphid natural enemies (hoverflies, coccinellids and lacewings) in several agro-ecosystems (corn, wheat, potato, broad bean) in northern Wallonia (Belgium). Five dominating aphidophagous species were observed, in decreasing order of importance: Episyrphus balteatus (De Geer), Chrysoperla carnea sensus lato (Stephens), Coccinella septempunctata (Linné), Harmonia axyridis and Propylea quatuordecimpunctata (Linné). The Multicolored Asian ladybird represents 8,7% of all observed aphidophagous species and 23,9% of coccinellids. Moreover, H. axyridis occurrence is two-times less important than C. 7-punctata. These results highlight that this invasive species is currently not the most abundant in southern Belgium agro-ecosystems and would not influence other aphid predators in those particular ecosystems. [less ▲]

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See detailIntegration of a new hysteresis model in the Finite Elements method
Scorretti, Riccardo; V Sabariego, Ruth ULg; Sixdeniers, F. et al

(2011)

In this work we present an original magnetic hysteresis model with parameters fitted from measured reversal curves. This model is used together with the Finite Element method for studying a structure ... [more ▼]

In this work we present an original magnetic hysteresis model with parameters fitted from measured reversal curves. This model is used together with the Finite Element method for studying a structure composed of a magnetic core with air-gap excited by a coil. [less ▲]

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See detailOn the Role of the Running Coupling Constant in a Quark Model Analysis of T-odd TMDs
Courtoy, Aurore ULg

in International Journal of Modern Physics Conference Series (2011), 04

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See detailConsidering Laminated Cores and Eddy Currents in 2D and 3D Finite Element Simulation of Electrical Machines
Gyselinck, Johan; Geuzaine, Christophe ULg; V Sabariego, Ruth ULg

(2011)

This paper deals with a time-domain homogeniza- tion method for laminated cores and its application to the 2D finite element simulation of rotating electrical machines. The number of additional degrees of ... [more ▼]

This paper deals with a time-domain homogeniza- tion method for laminated cores and its application to the 2D finite element simulation of rotating electrical machines. The number of additional degrees of freedom of the model, for considering the variation of the flux density along the lamination thickness, can be tuned so as to reach a good compromise between accuracy and computation time. The results obtained for a switched reluctance motor agree very well with those produced by a precise full 3D model in which eddy currents are explicitly modeled. [less ▲]

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See detailProduction subjective de rêve en milieu carcéral : une hypothèse adaptative
Englebert, Jérôme ULg; Gauthier, Jean-Marie ULg; Jacquemart, Catherine

Poster (2011)

Une étude sur le rêve n’est pas sans poser plusieurs questions épistémologiques et méthodologiques majeures. La première d’entre elles tient à l’essence même du rêve qui est un objet d’étude particulier ... [more ▼]

Une étude sur le rêve n’est pas sans poser plusieurs questions épistémologiques et méthodologiques majeures. La première d’entre elles tient à l’essence même du rêve qui est un objet d’étude particulier, étant strictement subjectif et difficilement objectivable. Le rêve n’existe dans la vie consciente qu’au passé ; il a une conscience uniquement rétrospective. Il existe donc un décalage temporel entre l’activité onirique et le discours sur le rêve. Ce hiatus temporel condamne donc le rêve à nous échapper dans sa finitude et pousse le chercheur à capituler face à la connaissance ultime et globale du monde imaginaire de l’individu. L’étude que nous avons réalisée se veut d’inspiration phénoménologique. Nous avons administré un questionnaire (questionnaire élaboré sous la supervision d’un collège d’experts travaillant en milieu carcéral) à une population de 48 détenus (43 hommes et 5 femmes) et à une population contrôle (appariée pour l’âge et le niveau d’étude). Le questionnaire était scindé en deux parties pour les détenus (rapport aux rêves avant l’enfermement [Gd.0] / rapport aux rêves maintenant [Gd.1]) et celui pour la population contrôle ne comprenait qu’une partie (rapport aux rêves maintenant [Gc]). Enfin, nous avons isolé trois groupes au sein de la population carcérale : Cp : Courte peine effectuée (maximum 90 jours), MP : Moyenne peine effectuée (plus de 90 jours et maximum 2 ans), LP : Longue peine effectuée (plus de 2 ans). Les résultats, qu’il conviendra de discuter dans le détail, mettent en évidence que l’activité onirique serait un mécanisme que le détenu utilise pour s’adapter à l’univers carcéral (la fréquence subjective de rêve et l’intérêt porté à ses rêves sont significativement plus importants pour le Gd.1 que le Gd.0 et le Gc). Mais ce constat tend à diminuer en fonction de la durée de la peine (au-delà de 2 ans d’enfermement [LP]). Nous pouvons expliquer cette diminution significative par un effet d’habituation (le rêve aurait permis un retour à une homéostasie psychique suffisante) ou par une abrasion du mécanisme. En effet, le rêve ne procurerait aucune modification dans le réel puisque le quotidien de l’enfermement reste le même. Privée de boucle de rétroaction, la fonction adaptative du rêve s’essoufflerait. [less ▲]

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See detailDisulfide bond assignment and folding characterization of peptide toxins by Ion Mobility Mass Spectrometry
Echterbille, Julien ULg; Quinton, Loïc ULg; Rosu, Frédéric ULg et al

Poster (2011)

Introduction Animal venoms are mainly composed of peptide toxins, which are highly structured by several disulfide bridges. Disulfide bridges are a key feature as (i) they increase the toxins efficiency ... [more ▼]

Introduction Animal venoms are mainly composed of peptide toxins, which are highly structured by several disulfide bridges. Disulfide bridges are a key feature as (i) they increase the toxins efficiency by lowering their immunogenicity; (ii) they provide the adequate conformation for high affinity binding to the biological receptor. The sequencing and the determination of the cysteine pairing is still challenging and therefore an important step in their structure analysis and the understanding of their interactions with receptors. In this work, we present a new strategy to sequence structured toxins and assign S-S bridges using ion mobility resolved MS/MS. Methods The method relies on the analysis of partially reduced multiple-disulfide peptide. The mixture of the different forms is resolved by ion mobility, followed by MS/MS acquisition on each mobility separated species. The proof of concept has been successfully conducted on α-CnI, a toxin purified from the venom of Conus consors marine snail. The toxin sequence is GRCCHPACGKYYSC-NH2. It contains four cysteines linked together with two disulfide bridges. α-CnI was partially reduced by a small excess of tris(carboxyethyl)phosphine (10:1) at 56°C during 30min. The resulting mixture was purified by ZipTip C18 micro columns before analysis by infusion nanoESI-Synapt-G2. Fragmentation was performed after the mobility cell, to obtain specific fragments of each species. Mobilograms and mass spectra were analyzed using MassLynx (v4.1) and Driftscope (v2.1) from Waters. Preliminary data Partial reduction of a-CnI was performed in order to obtain a mixture of oxidized (the two disulfides are formed), reduced (the two disulfides have been reduced) and partially reduced forms (only one of the two disulfides has been reduced). The arrival time distribution of triply charged ions reveals the presence of 4 different species, characterized by a different relative cross sections in the gas-phase. The charge state of the ions influences the ion mobility separation. Mass matching allows identifying the species: the first mobility (the most compact structure) was identified to be the oxidized folded toxin (M=1541.58 Da). The latest peak, corresponding to the larger cross-section, was identified as the fully reduced toxin (M=1545.6 Da). The second and the third mobility peaks were attributed to the two partially reduced forms in which only one disulfide bridge was reduced (M=1543.59 Da). The change in ion mobility depends on which S-S bridge is reduced. Ion mobility separated species give characteristic fragment ions upon fragmentation in the transfer cell (i.e. after ion mobility separator). Interestingly, fragment ions coming from partially reduced species, especially the C-S or S-S bond cleavages, clearly indicates that the disulfide linkage of α-CnI is (Cys1-Cys3) and (Cys2-Cys4) as expected from literature. The method is now being applied with success to more complex systems containing 3 or 4 disulfide bridges. The influence of the charge state on the mobility separation is systematically analyzed in terms of structural implications. Novel aspect Sequencing and disulfide bridges assignment of peptide toxins using ion mobility resolved MS/MS [less ▲]

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See detail10 façons d’interpréter une neuropathie asymétrique
WANG, François-Charles ULg

Conference (2011)

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See detailRoller Pressure Quench Process of Steel Plate Modelling
Lequesne, Cédric ULg; Pensis, O.; Renard, M. et al

in Proceedings of Esaform 2011 (2011)

In this study, the roller pressure quench process is applied on a low-alloy steel plate with significant thickness. The aim is to obtain martensitic high strength steel without modifying the flatness. In ... [more ▼]

In this study, the roller pressure quench process is applied on a low-alloy steel plate with significant thickness. The aim is to obtain martensitic high strength steel without modifying the flatness. In order to optimize the process parameters, a finite element model is developed. The analysis couples the mechanical, thermal and metallurgical fields. This model provides results about the final microstructure, the residual stresses and the flatness at the end of the cooling process. It has been noticed that a two dimensional plane strain simulation is not accurate because it does not predict physical transversal residual stresses. A three dimensional simulation improves the results and enables to compute the thickness variation of the plate at the end of the quench process. [less ▲]

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See detailDesign and analysis of two types of MEMS DC-DC step up voltage converters
Gleeson, R.; White, N. M.; Kraft, Michaël ULg

in MME 2011: Proceedings (2011)

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See detailCompelling untruths: the effect of aging on vivid false memories and memory editing
Dehon, Hedwige ULg; Lampinen, James Michael

Poster (2011)

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See detailThe crystal chemistry of olivine-type phosphates
Hatert, Frédéric ULg; Ottolini, Luisa; Fontan, François et al

Conference (2011)

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See detailProbing DNA interactions with gold
Bano, F; Leyh, Bernard ULg; De Pauw, Edwin ULg et al

Conference (2011)

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See detailEffect of different inlet flow conditions on turbulence in a straight compound open channel
Proust, S.; Peltier, Yann ULg; Fernandes, J. et al

in 34th IAHR Congr.: Balance and Uncertainty; Water in a Changing World (2011)

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See detailIon source development and radiobiology applications within the LIBRA project
Borghesi, M.; Kar, S.; Prasad, R. et al

in Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles (2011)

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See detailGlycemic Variability, Hypoglycemia and Organ Failure in the Glucontrol Study
Penning, Sophie ULg; Le Compte, Aaron J.; PREISER, Jean-Charles ULg et al

in 10th Belgian Day on Biomedical Engineering (2011)

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See detailMaxwell rigidity and topological constraints in amorphous phase-change networks
Micoulaut, M.; Otjacques, C.; Raty, Jean-Yves ULg et al

in AIP Conference Proceedings (2011), 1393

By analyzing first-principles molecular-dynamics simulations of different telluride amorphous networks, we develop a method for the enumeration of radial and angular topological constraints, and show that ... [more ▼]

By analyzing first-principles molecular-dynamics simulations of different telluride amorphous networks, we develop a method for the enumeration of radial and angular topological constraints, and show that the phase diagram of the most popular system Ge-Sb-Te can be split into two compositional elastic phases: a tellurium rich flexible phase and a stressed rigid phase that contains most of the materials used in phase-change applications. This sound atomic scale insight should open new avenues for the understanding of phase-change materials and other complex amorphous materials from the viewpoint of rigidity. [less ▲]

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See detailMOQUAC ? a Predictive GE-Model Based on Molecular Orientations
Bronneberg, Rob; Pfennig, Andreas ULg

Conference (2011)

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See detailParking pricing and its effect on urban traffic management system specially traffic congestion
Eftekhar, Hamed ULg; Rahmat, Riza Atiq

in USM ITRC 2011 proceeding (2011)

These days large cities are facing highly increase in populations and car dependency. In this condition an efficient urban traffic management system playing very important role to handle issued problems ... [more ▼]

These days large cities are facing highly increase in populations and car dependency. In this condition an efficient urban traffic management system playing very important role to handle issued problems. Urban traffic management system divided to two main parts. First one which is considered more yet is; current traffic and second one; quite traffic (parked vehicles) and its effects on current traffic have been considered less .Parking management is known as one of the most important tools in urban management. There are different items regarding to parking management that one of the most important one of them is parking pricing which has tremendous effects in an efficient urban traffic management system. In this paper we will discuss on why parking pricing and with an study case (UKM) will see how we can implement and predict about parking pricing and its affects parking demand and traffic volume and also mention how parking pricing can be considered as the second most effective congestion reduction strategy (after peak-period congestion pricing and before Vehicle Miles Traveled (VMT) taxes, fuel taxes and pollution emission fees). [less ▲]

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See detailInstability analysis of a horizontal evaporating binary liquid layer with transient reference profiles
Machrafi, Hatim ULg; Alexey, Rednikov; Colinet, Pierre et al

(2011)

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See detailA New Design Method for Solvent Extraction Columns Based on Single Drop Experiments
Buchbender, Florian; Pfennig, Andreas ULg

Conference (2011)

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See detailThe clinical and economic burden of poor adherence with osteoporosis medications in Ireland
Hiligsmann, Mickaël ULg; McGowan, Bernie; Bennett, Kathleen et al

in Value in Health (2011), 14

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See detailMandements épiscopaux et dispositif cérémoniel liégeois (XVIIe-XVIIIe siècle)
Delfosse, Annick ULg

in Bulletin de la Société d'Art et d'Histoire du Diocèse de Liège (2011), LXIX

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See detailInfluence of electrolytes on liquid-liquid separation
Chuttrakul, P; Kopriwa, N; Ruckes, S et al

Conference (2011)

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See detailRationalité de la forme et irrationalité du contenu dans l’école de Bade
Dewalque, Arnaud ULg

in Feron, Olivier (Ed.) Figuras da Racionalidade. Neokantismo e Fenomenologia (2011)

Je m'intéresse ici à ce qui fait la spécificité de la théorie de la rationalité dans l’école néokantienne de Bade, en particulier chez Jonas Cohn, Heinrich Rickert et Emil Lask. Ma thèse est que cette ... [more ▼]

Je m'intéresse ici à ce qui fait la spécificité de la théorie de la rationalité dans l’école néokantienne de Bade, en particulier chez Jonas Cohn, Heinrich Rickert et Emil Lask. Ma thèse est que cette spécificité réside prioritairement dans la distinction entre « forme » (Form) et « contenu » (Inhalt). Comme je tâcherai de le montrer, cette distinction est déterminante pour les deux versants de la théorie de la validité : la théorie de la connaissance et la théorie de l’objet, mais aussi pour ce que Rickert appelle la « théorie de l’état » (Zustandslehre), qui est l’équivalent néokantien d’une science du donné immédiat. [less ▲]

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See detail"Dichter der beiden Deutschland"? Ostdeutsche Blicke auf Uwe Johnson
Letawe, Céline ULg

in Hagestedt, Lutz; Hofmann, Michael (Eds.) Uwe Johnson und die DDR-Literatur (2011)

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See detailRapid regulation by glutamate of aromatase activity
Charlier, Thierry ULg; Ball, Gregory; Balthazart, Jacques ULg

Poster (2011)

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See detailResearch axes and conclusions
Erpicum, Sébastien ULg; Boillat, Jean Louis

in Erpicum, Sébastien; Laugier, Frederic; Boillat, Jean Louis (Eds.) et al Labyrinth and Piano Key Weirs - PKW 2011 (2011)

The aim of this short paper is to summarize main outcomes of the workshop, in order to guide future developments of research on Piano Key Weirs (PKW) towards most effective and integrated directions. The ... [more ▼]

The aim of this short paper is to summarize main outcomes of the workshop, in order to guide future developments of research on Piano Key Weirs (PKW) towards most effective and integrated directions. The main research topics highlighted in this text came out from the 34 high-quality presentations given during the conference, as well as from the fruitful discussions in which the participants were actively involved. Many more truly innovative and promising ideas can be found throughout the other papers gathered in this proceedings book. [less ▲]

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See detailFirst retrievals of methyl chloride from ground-based high-resolution FTIR solar observations
Mahieu, Emmanuel ULg; Harrison, Jeremy; Bernath, Peter F. et al

in Geophysical Research Abstracts (2011), 13

Methyl chloride (CH3Cl) is one of the most abundant chlorine-bearing gas in the Earth’s troposphere and a significant contributor to the organic chlorine budget. Measurements by in situ networks indicate ... [more ▼]

Methyl chloride (CH3Cl) is one of the most abundant chlorine-bearing gas in the Earth’s troposphere and a significant contributor to the organic chlorine budget. Measurements by in situ networks indicate a mean volume mixing ratio of 550 pptv, with a significant seasonal cycle of about 80 pptv, peak to peak. This species also exhibits inter-annual variability, but no long-term trend. Major sources are from tropical and sub-tropical plants and dead leaves, the oceans and biomass burning. Some industrial processes and waste incineration further add to the emissions. Oxidation by the hydroxyl radical is by far the largest CH3Cl sink, followed by soil uptake. Although balanced, its atmospheric budget is still affected by large uncertainties and contributions from unidentified sources and sinks cannot be ruled out. Methyl chloride has an atmospheric lifetime of 1 year, a global warming potential of 13 (100-yr horizon) and an ozone depleting potential of 0.02. The retrieval of methyl chloride from ground-based infrared (IR) spectra is very challenging. Indeed, numerous interferences by strong water vapor and methane lines complicate the detection of small CH3Cl absorptions, close to 1%, near 3 microns. In addition, and although weak, ethane features contribute to the difficulty, in particular since a significant number of ethane branches were absent until very recently from official HITRAN compilations. Therefore, the scientific literature does not report thus far about any investigations of CH3Cl from ground-based remote sensing observations. In this contribution, we will present first CH3Cl total column retrievals, using the SFIT-2 algorithm (v3.94) and high-resolution Fourier Transform Infrared (FTIR) solar absorption observations recorded with a Bruker 120HR instrument, at the high altitude station of the Jungfraujoch (46.5°N, 8°E, 3580 m asl), within the framework of the Network for the Detection of Atmospheric Composition Change (NDACC, visit http://www.ndacc.org). In our retrievals, we use new ethane absorption cross sections recorded at the Molecular Spectroscopy Facility of the Rutherford Appleton Laboratory (Harrison et al., 2010). They were calibrated in intensity by using reference low-resolution spectra from the Pacific Northwest National Laboratory (PNNL) IR database. These new cross sections were recently released as a HITRAN update (see http://www.hitran.com). Pseudoline parameters fitted to these ethane spectra have been combined with HITRAN 2004 line parameters (including all the 2006 updates) for all other species encompassed in the selected microwindows, including our target CH3Cl. We will evaluate the improvement brought by the new ethane line parameters on the fitting residuals, and characterize the quality, the precision and the reliability of the retrieved product. If successful, a long-term CH3Cl total column time series will be produced using the Jungfraujoch observational database, and we will perform preliminary investigations of the seasonal and inter-annual variations of methyl chloride total columns at northern mid-latitudes. [less ▲]

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See detailA potential intermediate in the evolution of superfast sonic swimbladder muscles in fishes
Fine, Michael; Mok, Hin-Kiu; Tsai, Kai-En et al

Conference (2011)

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See detailMuscular forces affecting the outcome of CCL surgery.
Ramirez, L.; Böhme, Béatrice ULg; Vroomen, Carl ULg et al

in Proceedings of the 20th ECVS Congress (2011)

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See detailSolvent extraction of systems with high viscosity
Pfennig, Andreas ULg; Adinata, D; Kröckel, J

in 19th International Solvent Extraction Conference, ISEC 2011, 204 & 1-7 (2011)

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See detailThe Lexicography of Ancient Italian
Aresti, Alessandro ULg

in Multi-disciplinary Lexicography: Traditions and Challenges of the XXI century (2011)

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See detailAcross breed and country validation of mid-infrared calibration equations to predict milk fat composition
Maurice - Van Eijndhoven, Myrthe; Soyeurt, Hélène ULg; Dehareng, Frédéric et al

in Book of Abstracts of the 62nd Annual Meeting of the European Association for Animal Production (2011)

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See detailDiagnosing pulmonary embolism from a model-based cardiac driver function
Stevenson, D; Revie, JA; Chase, JG et al

in Proceedings of ANZICS 2011 (2011)

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See detailFinancial analysis of poultry commodity chains in Hanoi Suburb, North of Vietnam
Phan Dang, Thang; Vu Dinh, Ton; Dogot, Thomas ULg et al

Conference (2011)

Poultry production plays an important role in the structure of familial incomes in Vietnam but this activity is currently met with difficulties caused by the great influence of inputs/outputs on the ... [more ▼]

Poultry production plays an important role in the structure of familial incomes in Vietnam but this activity is currently met with difficulties caused by the great influence of inputs/outputs on the markets and the risks of epidemic diseases. This research was conducted for interviews and records according to book keeping among 280 poultry smallholders; 100 intermediary agents of poultry meat supply chains at the various scales of poultry supply chains and the diversification of poultry markets (poultry producers, private hatcheries, collectors of live poultry, slaughter houses and distributors of poultry meat) in Hanoi Suburb between 2009 and 2010. This research aimed at addressing to improving the income of small poultry producers and identifying the intermediary economic agents and its economic distributions. Furthermore, this research would like to solve restoring the poultry production and the various restraints faced of food contamination in poultry meat supply chains. Institutional organization and financial analysis approaches in different agents was used to calculate the value-added and to explain this problem in poultry meat commodity chains. Institutional organization of poultry meat supply chains is really complex with diverse economic agents. There are not many poultry meat products have a good traceability. These recent years, broiler industrial chickens and ducks met with some difficulties with the profits were very unstable or loss-making. But this industrial broiler chicken still occupies more and more an important role for the demand of domestic consumers. In addition, color broiler chickens were chosen for more satisfying the Vietnamese taste. In fact, local or color crossbred broiler chickens have a good economic performance but the output is still instable. Traders of live poultry and manual slaughter-house have a good economic performance caused by using the source of familial labor and selling directly to consumers. The systems of automatic skill of live poultry have still limited. The consumers do not be informed the useful information on food safety standards. [less ▲]

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See detailPiano Key Weir preliminary design method – Application to a new dam project
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Erpicum, Sébastien; Laugier, Frederic; Boillat, Jean Louis (Eds.) et al Labyrinth and Piano Key Weirs - PKW 2011 (2011)

Within the framework of development of PKW use for rehabilitation as well as for new dam projects, the development of efficient design methods is essential. Currently, the design of PKW projects is done ... [more ▼]

Within the framework of development of PKW use for rehabilitation as well as for new dam projects, the development of efficient design methods is essential. Currently, the design of PKW projects is done by mean of scale modeling, on the basis of a geometry initially designed based on the general knowledge issued from idealized experimental studies and former PKW buildings. This paper presents a systematic method for PKW preliminary design. The method is based on extrapolation of existing experimental results to develop one or several available project designs, regarding the project constraints (discharge, reservoir levels, available space, …). The model permits then the optimization of the design depending on technical and economical interests (increase of the safety, decrease of the maximal head, limiting the weir dimensions, limiting construction costs, …). The application of the method to a new large dam project is presented, highlighting the interest of the method for the optimization of the design depending on technical and economical interests. [less ▲]

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See detailEvaluation de la performance des muscles extenseurs du tronc
Demoulin, Christophe ULg; GROSDENT, Stéphanie ULg; Crielaard, Jean-Michel ULg et al

in Kinesitherapie Revue (2011), 111

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See detailA Bayesian Approach for Modeling Origin-Destination Matrices
Perrakis, Konstantinos; Karlis, Dimitris; Cools, Mario ULg et al

in Proceedings of the 90th Annual Meeting of the Transportation Research Board (DVD-ROM) (2011)

The majority of Origin Destination (OD) matrix estimation methods focus on situations where weak or partial information, derived from sample travel surveys, is available. Information derived from travel ... [more ▼]

The majority of Origin Destination (OD) matrix estimation methods focus on situations where weak or partial information, derived from sample travel surveys, is available. Information derived from travel census studies, in contrast, covers the entire population of a specific study area of interest. In such cases where reliable historical data exist, statistical methodology may serve as a flexible alternative to traditional travel demand models by incorporating estimation of trip-generation, trip-attraction and trip-distribution in one model. In this research, a statistical Bayesian approach on OD matrix estimation is presented, where modeling of OD flows, derived from census data, is related only to a set of general explanatory variables. The assumptions of a Poisson model and of a Negative-Binomial model are investigated on a realistic application area concerning the region of Flanders on the level of municipalities. Problems related to the absence of closed-form expressions are bypassed with the use of a Markov Chain Monte Carlo algorithm, known as the Metropolis-Hastings algorithm. Additionally, a strategy is proposed in order to obtain predictions from the hierarchical, Poisson-Gamma structure of the Negative-Binomial model conditional on the posterior expectations of the mixing parameters. In general, Bayesian methodology reduces the overall uncertainty of the estimates by delivering posterior distributions for the parameters of scientific interest as well as predictive distributions for future OD flows. Predictive goodness-of-fit tests suggest a good fit to the data and overall results indicate that the approach is applicable on large networks, with relatively low computational and explanatory data-gathering costs. [less ▲]

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See detailTransport properties of nano-clay modified hydrophobic concrete
Di Maio, Luciano; Fariello, Maria Letizia; Scarfato, P. et al

in The new boundaries of strutural concrete (2011)

In this work the performance of a traditional concrete modified by the addition of nanoparticles and of a hydrophobic resin were studied. In particular, water capillary suction, water absorption at ... [more ▼]

In this work the performance of a traditional concrete modified by the addition of nanoparticles and of a hydrophobic resin were studied. In particular, water capillary suction, water absorption at atmospheric pressure and under vacuum, chloride diffusion, sulphates resistance and carbonation rate tests were carried out. The nanocomposite concrete (hydrophobic and not hydrophobic) shows efficacy in inhibiting the water absorption and CO2 transport thanks to the internal microstructure modification induced by the nanoparticles action which makes more difficult the passage of the substances. Hydrophobic concrete, instead, very effectively avoids the water inlet, but, because of its hydrophobic character, makes the pores of concrete unsatured of water and the CO2 can diffuse faster through the concrete bulk. [less ▲]

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See detailComputational FE² scheme for heterogeneous shell structures
Massart, Thierry J.; Mercatoris, Benoît ULg; Berke, Peter et al

Conference (2011)

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See detailMacropinocytosis of human papillomaviruses in natural killer cells via CD16 induces cytotoxic granule exocytosis and cytokine secretion
Renoux, V; Langers, I; Clémenceau, B et al

Poster (2011)

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See detailDirect observations of surface water-groundwater interaction using electrical resistivity tomography
Noell, U.; Wießner, C.; Ganz, C. et al

in IAHS-AISH Publication (2011)

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See detailGlucosamine sulfate for structure modification in osteoarthritis : fact of fantasy ?
Reginster, Jean-Yves ULg

in Ortopedia, Traumatologia, Rehabilitacja (2011), 13(S1), 44

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See detailLevels of PCDD/Fs and PCBs in Camel Milk (Camelus Bactrianus and Camelus Dromedarius) from Kazakhstan
Konuspeyeva, G; Faye, B; De Pauw, Edwin ULg et al

in Organohalogen Compounds (2011), 73

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See detailDu mur à la toile ou comment imiter le chromatisme de la "Cène" de Léonard de Vinci
Fagnart, Laure ULg

in Boudon-Machuel, Marion; Brock, Maurice; Charron, Pascale (Eds.) Aux limites de la couleur. Monochromie & polychromie dans les arts (1300-1600) (2011)

Cet article propose de répondre à la question suivante : comment les élèves de Léonard de Vinci, qui sont les auteurs de la plupart des versions fidèles et anciennes du Cenacolo, ont-ils imité les ... [more ▼]

Cet article propose de répondre à la question suivante : comment les élèves de Léonard de Vinci, qui sont les auteurs de la plupart des versions fidèles et anciennes du Cenacolo, ont-ils imité les couleurs du chef-d’œuvre de Santa Maria delle Grazie de Milan ? La question se révèle d’autant plus pertinente quand on sait que des gravures et des dessins monochromes ont servi d’intermédiaires pour réaliser des copies polychromes. Toujours est-il que, même si ces feuilles ont pu transmettre certaines indications permettant d’imiter le chromatisme du Cenacolo (en fait surtout une hiérarchie entre les tons clairs et les tons foncés), ces œuvres demeurent en noir et blanc. Elles constituent donc des intermédiaires trop sommaires pour minutieusement copier les couleurs de l’original. Or, les leonardeschi ont du recourir à des outils adéquats. Auraient-ils utilisé la série de dessins qui montrent les bustes des apôtres de Milan et qui sont conservés au Cabinet des estampes et des dessins des Musées de Strasbourg (inv. 295) ? C’est probable : ces feuilles proposent une solution au problème posé par le recours à un intermédiaire en noir et blanc puisqu’elles ont été exécutées à la pierre noire et à la sanguine, avec des rehauts de pastel coloré, c’est-à-dire selon un procédé qui permet justement d’enregistrer des couleurs. [less ▲]

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See detailRetirement incentives in Belgium
Jousten, Alain ULg

Conference (2011)

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See detailWhy do poverty reduction strategies not bring real effects in Northern Mountain, Vietnam ? Case of the commune of Xuan Phong and Tu Ly, Hoa Binh province
Mai, Lan Phuong ULg; Lebailly, Philippe ULg; Nguyen Mau, Dung

Conference (2011)

Agricultural accumulation has been one of the main source determined the social differentiation in Vietnamese countryside. The complexities of agrarian changes under the post - socialist industrialization ... [more ▼]

Agricultural accumulation has been one of the main source determined the social differentiation in Vietnamese countryside. The complexities of agrarian changes under the post - socialist industrialization with high rate of agricultural land conversion in recent context reveal the new forms of capital accumulation and social differentiation. This research investigates how land conversion process to industrial zones and clusters affected to the way that different groups of peasant households accumulate their resources. The study was carried out in 3 districts of Hung Yen province from 2006 to 2010. The study results are as follows: first, the land conversion to industrialization has impact on not only the decline of household landholdings but also the changes value of land which are the sources of social conflicts and informal land transfer. Second, in the context of land conversion to industrialization with tiny plots of land, low return from agricultural production and more opportunities of non-farm activities, even when non-farm employment is very profitable, peasant households are not likely to give up their land but maintaining agricultural production for not only their basic and secure livelihood but also for their identity. Third, among the affected peasant groups, the households with non-farm background tend to be in better position in engaging to high - earning activities. They are likely the rich peasants in opposed to the poor group with farming background and lost more than 50% of their agricultural land. This research has showed that the industrialization policies have to deal with the proportion of agricultural land would be transferred for industrialization zones and other measures in order to limit the conflicts as well as the social differentiation in countryside. [less ▲]

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See detailRelationship between PCB 153 and stable nitrogen in a Guiana dolphin (Sotalia guianensis) food weeb, Gunabara Bay, Brazil
Vidal, L. G.; Bisi, T. L.; Dorneles, P. R. et al

in Organohalogen Compounds (2011)

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See detailLack of P2X1 ion channels increases endotoxemia associated coagulation and organ damage through neutrophil hyperresponsiveness.
Lecut, Christelle ULg; Faccinetto, Céline ULg; Evans, Richard J et al

in Journal of Thrombosis and Haemostasis (2011), 9(suppl S2),

ATP-gated P2X1 ion channels contribute to arterial thrombosis by amplifying platelet activation. In the search for novel anti-platelet strategies, targeting P2X1 ion channels is appealing. However, in ... [more ▼]

ATP-gated P2X1 ion channels contribute to arterial thrombosis by amplifying platelet activation. In the search for novel anti-platelet strategies, targeting P2X1 ion channels is appealing. However, in this study we found that lack or inhibition of P2X1 channels enhanced neutrophil respiratory burst activity ex vivo. <br />To study the consequence of P2X1 deficiency on neutrophil function in vivo, P2X1-/- mice were used in a model of endotoxin-induced sepsis. Upon injection of lipopolysaccharides (LPS), plasma myeloperoxidase (MPO) concentrations reached higher levels in the P2X1-/- mice, and circulating neutrophils expressed higher levels of surface CD11b compared to wild-type mice. Neutrophil relocalization into the lungs of LPS-treated P2X1-/- mice was also significantly augmented, reflecting a higher activation state of P2X1-/- neutrophils under conditions of sepsis. Accordingly, more extensive lipid peroxidation was observed in the liver of LPS-treated P2X1-/- mice, indicative of exaggerated oxidative damage. Concomitantly, the levels of thrombin-antithrombin complexes were higher in the plasma of LPS-treated P2X1-/- mice and thrombocytopenia was worsened as compared to wild type mice. Elevated numbers of microthrombi were also found in the lungs of these mice. These observations coincided with a higher susceptibility of P2X1-/- mice to LPS-induced septic shock than wild type animals. <br />Our results strongly suggest that P2X1 ion channels play a protective role in sepsis by negatively regulating systemic neutrophil activation, thereby limiting oxidative damage, activation of coagulation and platelet accumulation into the lungs. Therefore, since antagonists of P2X1 ion channels may not only target platelets but also affect neutrophils, inhibiting these channels in the highly inflammatory environment of severe sepsis or of acute coronary syndromes might be detrimental. [less ▲]

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See detailHenri de Heer, médecin de cour et médecin de ville dans la Principauté de Liège au début du XVIIe siècle
Xhayet, Geneviève ULg

in Vons, Jacqueline; Velut, Stéphane (Eds.) Pouvoir médical et fait du prince au début des temps modernes (2011)

Detailed reference viewed: 60 (0 ULg)