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See detailInventory of Beekeeping in the Algerian north (Tizi-ouzou and Bejaia)
Yahi, Krimou; Touazi, Leghel; Kaidi, Rachid et al

Poster (2017, October 13)

The objective of this study is to make an inventory of the honey production in the counties of Bejaia and Tizi-Ouzou in northeastern Algeria. To achieve this, a survey was carried out on 31 beekeepers (14 ... [more ▼]

The objective of this study is to make an inventory of the honey production in the counties of Bejaia and Tizi-Ouzou in northeastern Algeria. To achieve this, a survey was carried out on 31 beekeepers (14 in Bejaia and 17 in Tizi-Ouzou). The survey shows a social, cultural and religious role for 61.29% of the beekeepers. The beekeeping is primarily held by men (93.55%). It is the basic source of income for 64.52% of the respondents. The average age of the beekeepers is 42.90years (Min-Max: 28-67 years, Median: 40.5 years). The main products of the hive are honey (100%), swarms (16.13%), royal jelly (9.68%) and propolis (9.68%). The average honey production per hive is 7.70kg (Min-Max: 0.4-15kg hives, Median: 10kg). The average number of hives per beekeeper is 42.20 hives (Min-Max: 3-300 hives, Median: 17.50 hives). The average selling price of one kg of honey is 4000.00 DA / kg (Min-Max: 2000-5000DA; Median: 4000DA). The phenotype of the bee reported by 74.19% of the surveys is of small size with a long body and dark pigmentation corresponding to the breed “Apis mellifera intermissa”. Two apiculturists described another phenotype corresponding to the “Apis mellifera major”. The factors behind the motivations for beekeeping are consumption of honey (100%), income generation (90.32%), hobby (58.06%) and conservation of biodiversity (22.58%). The multiple constraints associated with several diseases, notably Varroase (mentioned by 80.65% of beekeepers), cause difficulties for the breeders. Thus they cannot profit maximum from beekeeping. Other constraints which were reported are; forest fires (35.48%), wasps (32.26%), absence of beekeeping professionals or technicians (29.03%), harsh and cold winters with snow (19.35%), high density of hives in the region (16.13%) and uncontrolled spreading of pesticides and crop protection products at farms (12.90%). The economic situation of the Algerian beekeepers can be optimized by improving the production potential of the local bees. [less ▲]

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See detailMédium et discours scientifique. La chronique comme genre de la recherche ?
Mayeur, Ingrid ULiege

Conference (2017, October 13)

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See detailLe graffiti ou la consubstantialité du médium et de la situation d’énonciation
Mathy, Adrien ULiege

Conference (2017, October 12)

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See detailRelationship between brain activity and ocular movements during wakefulness and drowsiness
François, Clémentine; Wertz, Jérôme; Verly, Jacques ULiege

Poster (2017, October 11)

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See detailThe LNQ25 and ELN PVT Metrics Exhibit a Good Sensitivity to Sleep Deprivation and are Independent from the Subject
Latour, Philippe ULiege; Van Droogenbroeck, Marc ULiege

Poster (2017, October 09)

Introduction Performance of people undergoing critical tasks (like driving) may be impaired completely by the lowering of their vigilance level, due to sleep deprivation for instance. This reduction of ... [more ▼]

Introduction Performance of people undergoing critical tasks (like driving) may be impaired completely by the lowering of their vigilance level, due to sleep deprivation for instance. This reduction of performance may be measured by metrics computed from the reaction times (RT) recorded during a 10min Psychomotor Vigilance Test (PVT). Here, we analyze and compare the sensitivity to sleep deprivation and the subject dependent variability of the PVT metrics performance, with a special emphasis on the time interval sizes. Materials and Methods Individuals (22 volunteers; 11 males, 11 females, mean 22.2y., range 19-34 years) follow an uninterrupted 28h sleep deprivation standard PVT protocol during which they achieved two groups of three PVT sessions (in different conditions). The first PVT of each group is in Non-SDP condition (9h30 and 10h30 Day 1) and the second and third PVT of each group are in SDP condition (2h30, 3h30, 10h30 and 11h30 day 2). The subjects fill a sleep journal during the week before the experiment. We checked that they had a normal sleep-wake cycle with no sleep deprivation, jet-lag or shift work and no medication. During the PVT of the first group, the subjects were wearing the glasses of the Phasya’s Drowsimeter. We compute the usual PVT metrics; meanRT, meanRS (Reaction Speed) and LN500 (500ms lapses number). We also compute LNQ25 (adaptive lapses number computed with a subject dependent threshold) and ELN (Expected Lapse Number, computed from a subject-dependent estimation of the lapse probability). Results We use the “Effect Size” (ES, ratio of the mean by the standard deviation of the difference of metrics in the SDP and Non-SDP conditions) to assess the sensitivity to sleep deprivation. For the 10min (resp. 1min, 3min) interval, the ES of LNQ25 and ELN are respectively 1.38 (resp. 0.95, 1.22) and 1.35 (resp. 0.85, 1.14), the ES of meanRS, meanRT and LN500 are 1.23 (resp. 0.91, 1.09), 0.81 (resp. 0.54, 0.68) and 0.85 (resp. 0.63, 0.77). We classify the intervals on which metrics are computed as SDP or non-SDP. We use a fixed threshold for the metrics, independent of the subject. In the ROC curves, the TPR (for a FPR of 10%) assesses the quality of the classification, and then also the subject independence. For the 10min (resp. 1min, 3min) interval, the TPR of LNQ25 and ELN are respectively 0.86 (resp. 0.56, 0.75) and 0.83 (resp. 0.58, 0.75), the TPR of meanRS, meanRT and LN500 are 0.42 (resp. 0.38, 0.41), 0.40 (resp. 0.39, 0.40) and 0.42 (resp. 0.24, 0.30). Conclusions We demonstrate that LNQ25 and ELN enable a quite good classification of the SDP condition for time intervals greater than or equal to 3min, independently of the subject. On the other hand, these metrics provide also a good sensitivity to sleep deprivation. They outperform the usual metrics for both criteria. For time intervals below 3min, the performances degrade first progressively and then much more quickly below 1min. [less ▲]

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See detailJeu, narration et réflexivité : le rôle de l’avatar
Delbouille, Julie ULiege; Barnabé, Fanny ULiege

Conference (2017, October 06)

Par sa nature même, le jeu entretient avec la réflexivité une parenté certaine. En effet, pour qu’une situation ou un objet soit reconnu comme ludique par les participants, il est nécessaire que ces ... [more ▼]

Par sa nature même, le jeu entretient avec la réflexivité une parenté certaine. En effet, pour qu’une situation ou un objet soit reconnu comme ludique par les participants, il est nécessaire que ces derniers superposent à leur action le message « ceci est un jeu » (Bateson, 1977). L’acte ludique, le « jouer » (Henriot, 1989), constitue donc un procédé de « méta-communication » (Bateson, 1977) supposant une interaction au second degré avec le réel (le joueur « fait comme si » ; Schaeffer, 1999 : 11). Le jeu vidéo n’échappe pas à cette dynamique réflexive, comme en témoigne le nombre important d’œuvres vidéoludiques qui – par le biais de différents outils formels – discourent sur leur propre organisation ludo-narrative, sur leurs possibilités d’utilisation ou sur le médium qui les supporte. Cette parenté entre réflexivité et jeu explique sans doute en partie la fréquence, au sein de ce domaine, des figures transgressant les seuils de la narration. Ainsi, dans les jeux vidéo, les métalepses sont des procédés tout à fait banals et non problématiques. Il n’est pas rare, par exemple, que des personnages fictionnels expliquent les mécaniques ludiques à l’avatar en des termes mêlant la fiction et l’univers référentiel du joueur (comme dans ces exemples issus du jeu Le monde de Nemo : « “(...) tu peux accélérer en appuyant sur la flèche de déplacement (...)”, “(...) tu peux peut-être y arriver en appuyant sur la touche action (...)” » ; Nélide-Mouniapin, 2005 : 245). Plus généralement, tout avatar de jeu vidéo se rapproche de ce que Genette nomme un « opérateur de métalepse » (Genette, 2004 : 110). En faisant se rencontrer un joueur empirique et un personnage fictif, cette « enveloppe pilotable » (Amato et Perény, 2013) assure effectivement une fonction d’embrayeur. Point de passage privilégié vers le monde fictionnel, l’avatar acte continuellement la perte et la reprise du contrôle sur le jeu, interrogeant ainsi le joueur sur sa propre posture – lorsqu’il n’est « ni tout à fait en [lui-même], ni tout à fait à l’écran, mais dans une zone intermédiaire, un entre-deux » (Triclot, 2011 : 19). La fréquence des métalepses ou mises en abyme dans les jeux et la centralité du rôle de l’avatar dans ces procédés réflexifs interrogent la manière dont le jeu vidéo peut construire une narration. En effet, ces figures peuvent être envisagées comme les vecteurs d’une destruction du pouvoir de représentation de l’œuvre, puisqu’elles mettent en pause la construction d’un univers pour faire discourir le jeu sur lui-même. Afin de mettre au jour les mécanismes de ces ruptures des seuils de la fiction et leur fonction dans l’articulation du jeu et de la narration, notre communication analysera ces procédés en puisant des exemples au sein de trois jeux distincts : Portal (Valve Corporation, 2007), ​The Stanley Parable (Galactic Cafe, 2013) et ​INSIDE (Playdead, 2016). Ceux-ci ont effectivement en commun de mettre en abyme le rapport du joueur à la machine par ​ le biais de leurs avatars (et de leur relation respective avec GLaDOS dans ​Portal, avec le​ narrateur dans The Stanley Parable, et avec le deuxième avatar dans ​INSIDE). Dans ces trois œuvres, les personnages jouables sont les opérateurs d’un méta-discours qui – tout en ne cessant d’opérer des « sorties » hors de la fiction pour s’adresser au joueur empirique – constitue en vérité le socle de la narration elle-même. [less ▲]

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See detailSelf et perspective en première personne
Englebert, Jérôme ULiege; Monville, François

Conference (2017, October 06)

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See detailDrepakis : Contribution to the management of Sickle cell disease in the city of Kisangani (D.R. Congo)
Marini Djang'Eing'A, Roland ULiege; Batina Agasa, Salomon; Gulbis, Béatrice et al

Conference (2017, October 06)

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See detailAux origines de l'Université de Liège
Lanneau, Catherine ULiege

Conference (2017, October 06)

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See detailThe mathematical challenges in agrogeophysics: examples and ways ahead
Garré, Sarah ULiege; Nguyen, Frédéric ULiege; Lesparre, Nolwenn ULiege et al

Conference (2017, October 05)

Electrical resistivity tomography (ERT) is increasingly used in the context of agriculture since the measured resistivity distribution can be linked to soil moisture, soil structure or pore water salinity ... [more ▼]

Electrical resistivity tomography (ERT) is increasingly used in the context of agriculture since the measured resistivity distribution can be linked to soil moisture, soil structure or pore water salinity. Due to its minimally invasive character, its spatial coverage and its monitoring abilities, ERT can be used to study field heterogeneity and competition between plants, quantify water fluxes throughout a growing season or distinguish preferential flow pathways in soils. Nevertheless, a lot of challenges still remain. From a mathematical point of view, the inverse problem linked to ERT is ill-posed. To solve it, the inverse problem is often regularized with a Tikhonov-type approach. The latter is typically done using a gradient operator, resulting in smoothed resistivity distribution. However, strong contrasts can exist due to e.g. compacted soil layers due to ploughing, water infiltration fronts, etc. In such a case, other operators such as the total variation or the minimum gradient support may be used. In such approaches, the selection of the regularization parameter with respect to the data quality and the definition of image appraisal indicators still remains a challenge. Uncertainty quantification of ERT-derived results often relies on data-error propagation around the inverse solution. Given the inherent non-uniqueness of the problem, both mathematically but also from a pedological point of view, challenges for stochastic approaches lie in providing realistic uncertainty estimation, encompassing all uncertainties (e.g. prior, pedophysics or data error). Monitoring data allows further elements to constrain the inverse problems, data can be replaced by data difference and regularization may incorporate the temporal dimension for instance. However, such constraints require their compatibility with the studied temporal process. Whereas the above challenges stay true for monitoring data, several alternative strategies are being developed more specifically, such as coupled hydrogeophysical inversion, with the challenge of addressing the non-stationarity of pedophysical relationships and the accuracy of the conceptual flow and transport model using deterministic approaches. Stochastic approaches allow to a certain extent to tackle those challenges in particular using a prior falsification/validation approach following a Popper-Bayes philosophy. In this presentation, we will illustrate the challenges and some of the recent developments with numerical and field examples. [less ▲]

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See detailExperiences with using netCDF 4
Troupin, Charles ULiege; Watelet, Sylvain ULiege; Barth, Alexander ULiege et al

Conference (2017, October 05)

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See detailInvestigation of content of Panda oleosa (Pierre), a plant used in Kisangani areas for its antihyperglycemic activity
Katemo Muhoya, Frédéric; Kadima Ntokamunda, Justin; Njakarinala Ranarivelo et al

Conference (2017, October 05)

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See detailL’intention des maitres de stage lié à l’utilisation d’un référentiel de compétences
Detroz, Pascal ULiege; Giet, Didier ULiege; MASSART, Valérie ULiege et al

Conference (2017, October 05)

En s’appuyant notamment sur deux référentiels internationaux : le WONCA tree et le Canmeds une équipe de travail, constituée des enseignants du département de médecine générale de notre institution ... [more ▼]

En s’appuyant notamment sur deux référentiels internationaux : le WONCA tree et le Canmeds une équipe de travail, constituée des enseignants du département de médecine générale de notre institution, accompagnés de 20 médecins en activité, a listé les activités et tâches que devait pouvoir accomplir un clinicien compétent. Ils ont ensuite organisé ces tâches en six grandes catégories. Pour chacune d’elles, une compétence centrale a été identifiée, ainsi qu’une série de familles de situations dans lesquelles cette compétence est mobilisée. Une fois finalisé, le document a été soumis à un panel d’experts de terrain et aux étudiants pour validation afin de s’assurer que le projet soit perçu comme dynamique et mobilisant. Le référentiel terminé, la seconde étape méthodologique a été la reconfiguration de l’enseignement pour qu’il permette l’atteinte des compétences visées. Le problème qui s’est posé à l’équipe enseignante est qu’une partie importante de la formation se fait en dehors des murs de l’université : elle se passe en de nombreux lieux de stage sous la supervision de maîtres de stage, souvent des médecins en activité ayant pour la plupart peu de lien avec la faculté. Afin d’être efficace, il est cependant nécessaire que l’ensemble des intervenants dans la formation des étudiants, y compris ces maîtres de stages, utilise le référentiel de formation comme référent aux activités d’apprentissages proposées aux étudiants. Or, une telle utilisation ne coule pas de source. L’objectif de cette étude est de connaître les intentions des maîtres de stage (MdS) quant à cette utilisation. Afin de connaître les éléments prédicteurs de cette intention, nous avons fait appel à la théorie du comportement planifié (Ajzen, 1985, 1991 ; Ajzen et Fishbein, 2005) pour guider notre démarche. Ce modèle est réputé comme étant le plus puissant pour prédire les comportements. Il a été utilisé dans de très nombreuses études, y compris dans le domaine de la santé. (Reid et Wood, 2008, Hardeman et al, 2002, Stecker, Fortney, Hamilton et Ajzen, 2007)… Selon cette théorie le comportement peut être directement prédit à partir d’une intention et celle-ci est déterminée par trois facteurs. [1] l’attitude envers le comportement [2] La norme subjective et [3] Le contrôle perçu. Conformément à la méthodologie proposée par Ajzen, nous avons dès lors conçu un questionnaire mesurant de manière directe et indirecte les divers paramètres de ce modèle (attitudes, normes sociales et contrôle perçu) sur la base de sept entretiens avec des maîtres de stage. Ce questionnaire a ensuite été proposé à la population des Maitre de Stage. Nous avons obtenu 68 réponses. Après avoir effectué des régressions hiérarchiques pas à pas ascendantes, nous avons conclu qu’ensemble, les attitudes, les normes sociales et le contrôle perçu expliquaient 83 % de l’intention d’utiliser le référentiel. D’autres analyses ont permis de déterminer les leviers et les freins influant directement sur cette intention. Ils seront présentés lors de notre communication. [less ▲]

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See detailQuantitative profiling of endogenous polar metabolites from low volumes of blood samples
Kok, Miranda ULiege; Fillet, Marianne ULiege

Poster (2017, October 05)

The etiology of many diseases is not yet completely understood. The involved biological processes might be resolved using a metabolomics approach, because metabolomics provides unique challenging ... [more ▼]

The etiology of many diseases is not yet completely understood. The involved biological processes might be resolved using a metabolomics approach, because metabolomics provides unique challenging opportunities to correlate the metabolome with a physiological or pathophysiological status and provides a vision on the relationships between genes, gene expression, environment and lifestyle. Here, we present the development of two ultra-high performance liquid chromatography (UHPLC) methods coupled to mass spectrometry (MS) for the separation and quantitation of polar metabolites in blood samples. A reversed-phase UHPLC-MS/MS method has been developed to quantify anionic energetic metabolites, whereas hydrophilic interaction chromatography (HILIC)-MS/MS has been used to determine amino acids. Two sample pretreatment procedures have been developed for an optimal recovery of the respective metabolites from whole blood samples. One method involved the precipitation of proteins with acetonitrile and acids. In addition, volumetric absorptive microsampling has been used for the sample preparation. Small and accurate quantities of biological fluids (10 or 20 µL) can be collected with this sampling technique, which is of great interest for volume-limited samples or serial collection of samples. The developed methods have been validated and will be applied to determine differences in metabolite concentrations between plasma samples from patients and controls. This can lead to a breakthrough in the understanding of diseases and can open new therapeutic perspectives. [less ▲]

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See detailPoor quality medicines in Africa: how to combat this real scourge
Marini Djang'Eing'A, Roland ULiege; Sacre, Pierre-Yves ULiege; Ziemons, Eric ULiege et al

Conference (2017, October 04)

Poor (or low) quality medicines remain a crucial problem of public health around the world. They encompass falsified /counterfeit, substandard or degraded drugs. If proportion of 1% is estimated in ... [more ▼]

Poor (or low) quality medicines remain a crucial problem of public health around the world. They encompass falsified /counterfeit, substandard or degraded drugs. If proportion of 1% is estimated in developed countries, they are globally about 10 % of counterfeit drugs according to Food and Drug Administration, with 30% in low income countries and astonishing values (80 %) reported in some African countries. The consequences and dangers of such medicines are therapeutic failure, drug poisoning, microbial resistance or even death. For the pharmaceutical industries, there are loss of image, loss of financial income and employment. There is need to combat this scourge, but most of the time, means are very limited and even lacking. In this context, several means or tools are developed by the ULg Pharmacy Department including the simple ones including organoleptic tests, simple analytical tests such as analytical balance, pHmeter, thin layer chromatography (TLC), UV-visible spectrophotometry to the more complex including liquid chromatography (LC) coupled to UV-Vis detector, or to mass spectrometry, nuclear magnetic resonance, Raman imagery (RIM) and near infrared (NIR) spectroscopy associated with the principal component analysis (PCA). In this way, we have analyzed several suspected samples obtained via the public health authorities of the D.R. Congo, Benin and Rwanda after their seizure or through collaborations. The results are presented by therapeutic class, namely: analgesics: - by using LC and complementary information from victim patients, we were able to discover an abnormal presence of a benzodiazepine at very high doses in paracetamol tablets which was the cause of unusual adverse effects (sedative effects, polyuria and hypotension) in patients who have consumed it; - by using the NIR-PCA, we were able to elucidate the substitution of an excipient (glycerol) by diethylene glycol in paracetamol syrup which caused the death of a hundred babies. antimalarials: - we faced cases of arthemether-lumefantrine tablets which had no therapeutic effect. By means of TLC and LC, the absence of these two active ingredients was clearly demonstrated, but the presence of starch was revealed by RIM; - another case of quinine tablets that had no expected pharmacological effect was faced. The use of several combined techniques (TLC, LC-MS, NMR and RIM) allowed to detect the presence of a substance with an imidazole structure (antamoeba). antibiotics: - the case of amoxicillin powder which after reconstitution in hospital caused poisoning of the babies until death for some was investigated. The reconstitution of the suspension in the laboratory had revealed the misuse of hydrogen peroxide instead of distilled water; - we participated to a large-scale study (80 samples of amoxicillin powder) that showed 8% of overdose. The cases presented indicate that there are effectively poor quality medicines and there is need to sustain strong collaborations while reinforcing appropriate measures to protect users. [less ▲]

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See detailValidité et utilité d'un test d'orientation dans le secteur de la santé en Fédération Wallonie Bruxelles
Detroz, Pascal ULiege; Monseur, Christian ULiege; Romainville, Marc et al

Poster (2017, October 04)

La Fédération Wallonie Bruxelles de Belgique n’avait pas, jusqu’en 2016, de Filtres à l’entrée des études de Médecine. Elle avait par contre un test diagnostique, formatif, obligatoire, mais non ... [more ▼]

La Fédération Wallonie Bruxelles de Belgique n’avait pas, jusqu’en 2016, de Filtres à l’entrée des études de Médecine. Elle avait par contre un test diagnostique, formatif, obligatoire, mais non contraignant (il n'avait pas d'effet sur l'avenir des étudiants). Ce test se présentait sous la forme d’un questionnaire à choix multiple (QCM) évaluant plusieurs matières : la chimie, la physique, la biologie, les mathématiques, le français et l’anglais. Il se déroulait en même temps sur le site des cinq universités concernées par les études dans le domaine de la santé de la FWB. Les questions du test sont identiques dans ces différentes universités. Il a été organisé entre 2013 et 2016 , deux fois par année en juillet et septembre. L’enjeu était de permettre aux étudiants de mesurer leur compétence à l’entrée des études pour se rassurer (pour les plus fort d’entre eux), pour s’améliorer à travers des activités de remédiation, ou éventuellement pour renoncer (pour les pl us faible d’entre eux). La présente étude a pour objet d’évaluer l’efficacité de ce test diagnostic. Concrètement, les objectifs de l'étude décrite étaient de/d’ : 1. Analyser la qualité psychométrique du test d'orientation. 2. Établir le lien entre les données biographiques de l’étudiant et les résultats au test d'orientation. 4. Établir le lien entre les résultats au test d'orientation et l’inscription réelle en faculté de médecine.(l'effet de dissuasion du test) 3. Établir le lien entre le test d'orientation et la réussite globale et par matière à la fin de la première année. Nos conclusions générales sont les suivantes : Les tests d’orientation présentent une bonne qualité psychométrique. C’est toutefois plus vrai pour les disciplines scientifiques que pour l’anglais et le français. Le test vise bien les aptitudes spécifiques et les compétences prérequises pour entreprendre des études supérieures dans le secteur de la santé. Les candidats proviennent d’un milieu socio-économique élevé et présentent un parcours scolaire au dessus de la moyenne. Ces variables expliquent, chez les étudiants diplômés du secondaire en Belgique, plus de 30% de la variance du score de sciences au test d'orientation (score factorisé à partir des scores de maths, bio, chimie et physique) et plus de 10% du score de langue (score factorisé à partir des scores de français et d’anglais) à ce même test. Ces mêmes variables de présage expliquent aussi en partie le résultat en fin de premier bachelier (22% de variance expliquée pour les étudiants diplômés en Belgique, 34% pour les étudiants diplômés en France). Les résultats aux tests d’orientation, quant à eux, expliquent ensemble 29% de la variance aux résultats de bac1 pour les étudiants diplômés en Belgique et 17% pour ceux diplômés en France. Le test de sciences s’avère beaucoup plus prédictif que le test de langues Les test dissuade peu les étudiants les plus faibles de s’inscrire. Ces résultats seront présentés lors de la communication [less ▲]

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See detailNotebooks for documenting work-flows
Troupin, Charles ULiege; Barth, Alexander ULiege; Muñoz, Cristian et al

Conference (2017, October 02)

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See detailEvolution of rate and genotypes of resistance to macrolide/lincosamide among invasive Group B Streptococcus (GBS): Development of a multiplex PCR tool for simultaneous detection of ErmB, ErmTr, MefA and LsaC resistance genes.
SACHELI, Rosalie ULiege; DESCY, Julie ULiege; MEEX, Cécile ULiege et al

Poster (2017, October)

Methods: A multiplex-PCR, using a set of specifically designed or already described (Kataja, 1999; Malbruny, 2011) primers was developed and used to detect, in GBS, three genes for erythromyc resistance ... [more ▼]

Methods: A multiplex-PCR, using a set of specifically designed or already described (Kataja, 1999; Malbruny, 2011) primers was developed and used to detect, in GBS, three genes for erythromyc resistance, ermB, ermTR, mefA and one gene for clindamycin-resistance lsaC. AdhP gene amplification was used as control for GBS identification. All(219) GBS isolates from invasive infections in newborns and adults received by the Belgian National Reference Center for GBS in 2015, and control strains were tested for erythromycin/clindamycin susceptibility (disk-diffusion/broth- microdilution) and for detection of resistance genes. Results: PCR products demonstrated the expected respective sizes. The method has been validated successfully according to ISO15189 analytical requirements. Of the 219 isolates, 67(30,67%) w resistant to erythromycin and/or clindamycin: 44/67(65,78%) showed a constitutive-MLS phenotype and 10/67(14,9%) the inducible-MLS phenotype. Among the constitutive-MLS strains, 73% harboured ErmB gene, 13% ErmTR, 7% ErmB+mefA and 7% ermB together with LsaC gene. The inducible-MLS strains harboured mostly ErmTr gene (89%) and the others the ErmB gene. Among the 10/67(14,9%) GBS strains with an M-phenotype (isolated resistance to erythromycin), the MefA gene was exclusively detected. Among the 3(4,48%) strains showing an isolated resistance to clindamycin (L-phenotype), the LsaC gene was detected. Conclusion: The developed multiplex PCR is able to detect simultaneously four genes involved in MLS resistance in GBS. In 2015, 30,6% of the invasive GBS strains isolated in Belgium were resist to macrolides and/or lincosamides. The emergence of the L-phenotype in GBS described since 2010, justifies the relevance to also detect LsaC gene together with ErmB, ErmTr and MefA. [less ▲]

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See detailImprovement of battery life of iPhones Inertial Measurement Unit by using edge computing Application to cattle behavior
Debauche, Olivier ULiege; Mahmoudi, Saïd; Manneback, Pierre et al

Conference (2017, October)

Smartphones, particularly iPhones, can be relevant instruments for researchers widely used around the world in multiple domains of applications such as animal behavior. iPhones are readily available on ... [more ▼]

Smartphones, particularly iPhones, can be relevant instruments for researchers widely used around the world in multiple domains of applications such as animal behavior. iPhones are readily available on the planet, contain many sensors and require no hardware development. They are equipped with high performance inertial measurement units (IMU) and absolute positioning systems analyzing users movements, but they can easily be diverted to analyze likewise the behaviors of domestic animals such as cattle. Using smartphones to study animal behavior requires the improvement of the autonomy to allow the acquisition of many variables at a high frequency over long periods of time on a large number of individuals for their further processing through various models and decision-making tools. Storing, treating data at the iPhone level with an optimal consumption of energy to maximize battery life was achieved by using edge computing on the iPhone. It reduced the size of the raw data by 42% on average by eliminating redundancies. The decrease in sampling frequency, the selection of the most important variables and postponing calculations to the cloud allowed also an increase in battery life by reducing of amount of data to transmit. [less ▲]

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See detailUpdate of the characteristics of Group B Streptococci (GBS) colonizing pregnant women in Belgium: capsular-type distribution, pili characterization, antimicrobial susceptibility profile and Multiple Locus Sequence Types.
SACHELI, Rosalie ULiege; MEEX, Cécile ULiege; DESCY, Julie ULiege et al

Poster (2017, October)

Aim: Improving knowledge and characterization of GBS strains colonizing pregnant women in Belgium. Methods: In 2013, collection of 387 strains of GBS from 80 laboratories participating in a national ... [more ▼]

Aim: Improving knowledge and characterization of GBS strains colonizing pregnant women in Belgium. Methods: In 2013, collection of 387 strains of GBS from 80 laboratories participating in a national survey among pregnant woman. For each strain, determination of capsular-polysaccharide type agglutination and PCR, of pili-type by PCR and of antimicrobial susceptibility by disk-diffusion, broth-microdilution and detection of resistant genes by PCR. For serotype III strains, determination sequence-type by Multiple-Locus Sequence-Typing (MLST). Results: Serotype III was the most prevalent (28.5%) followed by serotypes V, Ia, II, IV and Ib (20.4%, 19.9%, 17.8%, 7%, 5.4%). Serotypes VI, VII and IX were found each once. All strains remained susceptible to penicillin (MICs: 0.03-0.125 mg/L) and other beta-lactams tested; 28.7% were resistant to erythromycin and 26.7% to clindamycin. With regards to pili, all 387 strains harboured one the PI-2 variants alone or in combination and 70.3% contained PI-1. The 110 serotype III isolates were resolved into 18 STs. The most common were ST-17 (35.5%) followed by ST-19 (30%) and ST- ST-27, ST-23 (<=5%). Conclusion: Among GBS from colonized pregnant women in Belgium: capsular-type and pili distributions, and MLST profile among type III strains were quite similar to reported data from Europ and USA during the last decade. As showed in this study, penicillin remains the first line drug of choice. On the contrary, resistance rates against macrolides/lincosamide, has reached a plateau since a decade, but it is noteworthy to notify the emergence of strains with isolated resistance to clindamycine. [less ▲]

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See detailPrevalence and characteristics of group B streptococcus colonization in HIV-infected pregnant women in Belgium
DAUBY, Nicolas; ADLER, Catherine; Y MIENDJE DEYI, Véronique et al

Poster (2017, October)

Objectives: High incidence of GBS sepsis has been reported in HIV-exposed but uninfected (HEU) infants in both developed and developing countries, particularly late-onset diseases. We aimed determining ... [more ▼]

Objectives: High incidence of GBS sepsis has been reported in HIV-exposed but uninfected (HEU) infants in both developed and developing countries, particularly late-onset diseases. We aimed determining the prevalence, the characteristics and the risk factors of GBS carriage in HIV-infected and HIV uninfected pregnant women (PW). Methods : Between 1/01/2011 and 31/12/2013, HIV-infected (n=132) and uninfected (n=123) PW had recto-vaginal swabs for GBS detection performed at 35-37 weeks of gestation and at deliver Demographic, obstetrical and medical data related to HIV-infection were prospectively collected. Serotyping of GBS strains was performed on a limited number of randomly selected samples (26 from HIV-infected and 13 from uninfected PW). Results : The overall prevalence of GBS carriage was not statistically different between HIV-infected and uninfected PW (31% vs 24,4% respectively). Age, nadir CD4 cell count, CD4 cell count at delivery and detectable viral load at delivery were not associated with GBS carriage rate in HIV-infected PW. A distinct pattern of GBS serotype was found in HIV-infected PW who were predomina colonized by serotype III (12/26) while HIV-uninfected PW were mostly colonized by serotype Ia (8/13) (p<0,05). Conclusions: As previously reported in other countries, HIV-infected PW do not have significantly higher rate of GBS colonization. However, our results suggest that HIV-infected PW are more lik be colonized with serotype III strains, that is the main serotype associated with late-onset neonatal sepsis. Ongoing research aims at characterizing the clonal features of the isolated strains [less ▲]

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See detailSoftware citation and process traceability
Troupin, Charles ULiege; Muñoz, Cristian; Rújula, Miquel Angel et al

Conference (2017, October)

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See detailLifetime of 5 non-commercial boluses evaluated in dairy cows by X Rays and plasmatic trace elements concentrations
Guyot, Hugues ULiege; Cheleux, Gaël ULiege; Wajda-Dubos, Jean-Pierre et al

Poster (2017, October)

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See detailPrevalence and capsular-polysaccharide type distribution of colonizing group B streptococci (GBS) isolated from recto-vaginal samples in pregnant women in Hanoï, Vietnam
MEEX, Cécile ULiege; DEVEY, Anaïs ULiege; PHAM HONG, Nhung et al

Poster (2017, October)

Background: The study was organized by the Belgian National Reference Center (NRC) for Streptococcus agalactiae or GBS, and carried out in Vietnam. The aim of the study was to determine the prevalence of ... [more ▼]

Background: The study was organized by the Belgian National Reference Center (NRC) for Streptococcus agalactiae or GBS, and carried out in Vietnam. The aim of the study was to determine the prevalence of GBS colonization among pregnant women in Hanoï and to characterize the capsular-polysaccharide (CPS) type of the isolated strains. Methods: For a 2-months period in 2015, 888 recto-vaginal swabs were collected in Bach-Mai-Hospital from pregnant women at 35-37 weeks’ gestation and were cultured for detection of GBS. Strains were stored and transferred to the Belgian NRC for further characterization. CPS-typing was performed by both latex agglutination and PCR (Poyart, 2007; Kong, 2008). Results: Among the 888 swabs, 111 were positive for GBS, that is a prevalence of colonization of 12.5%. A total of 90 strains were available for typing: 91,11% could be serotyped by latex agglutination and all the strains, including the 8 phenotypically non-typable strains, were successfully genotyped. CPS type V was the most prevalent (36.7%) followed by CPS types Ib (25.6%), III (21.1%), VI and VII (8.9% and 4.4%). CPS type II was found twice and serotype Ia was found once. CPS types IV, VIII and IX weren’t present in this population. Conclusion: With predominance of types V, Ib and III, this distribution of CPS-types of GBS colonizing pregnant women in Hanoï, Vietnam, differs from distributions described in Europe and in o Asian countries. This study provides useful information for the development of a universal vaccine that could contribute to improve the prevention of neonatal GBS infections. [less ▲]

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See detailLe cinéma déboussolé
Pieron, Julien ULiege

Conference (2017, September 29)

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See detailExploring possibilities through imagination. What can be conceived and what can be seen
Leclercq, Bruno ULiege

Conference (2017, September 29)

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See detailAdénocarcinome du canal anal: identification de deux sous-types distincts
Herfs, Michael ULiege

Conference (2017, September 29)

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See detailParler le langage de l'ennemi: la revue TINA contre le storytelling
Claisse, Frédéric ULiege

Conference (2017, September 29)

Dans le sillage des analyses de C. Salmon (2007), le storytelling est devenu, en France, un terme repoussoir utilisé pour dénoncer des techniques nouvelles de communication politique, de marketing ou de ... [more ▼]

Dans le sillage des analyses de C. Salmon (2007), le storytelling est devenu, en France, un terme repoussoir utilisé pour dénoncer des techniques nouvelles de communication politique, de marketing ou de gestion des organisations, qui adoptent la forme du récit à des fins explicites d’influence ou de manipulation. Cette mobilisation de « l’art de raconter des histoires » dans des contextes extra-littéraires n’a pas manqué de faire réagir certains écrivains, inquiets de cette concurrence illégitime sur leur propre terrain. En donnant un nom à « l’ennemi », l’essai de Salmon a ainsi eu pour effet de rendre disponible un nouveau répertoire critique et d’ouvrir à de nouveaux questionnements quant aux pouvoirs que pourrait opposer la littérature à cette emprise de la logique marchande, véritable « hold-up sur l’imaginaire ». Cette réaffirmation de la littérature passe par la promotion de la singularité de son rapport au récit et au langage contre leur dévoiement et leur instrumentalisation par le néolibéralisme. Le mouvement critique s’opère à deux niveaux au moins. D’une part, face à l’inauthenticité du langage du storytelling, l’écriture poétique, déjà profondément renouvelée dans ses modes d’expression depuis les années 1990 (Espitallier, 2011), a encore multiplié la production d’ « objets littéraires non identifiés ». Ces derniers, que C. Hanna théorise sous le nom de « dispositifs » (2010), sont caractérisés par un niveau élevé d’expérimentation, dans des formes et des formats qui investissent souvent ou détournent le « langage de l’ennemi » (pour reprendre l’expression de J-C. Masséra), afin de le dynamiter de l’intérieur (E. Arlix, Y. Pagès, H. Jallon). D’autre part, face à l’impuissance dans laquelle nous laissent les récits dominants, le pouvoir qu’ont les récits d’affecter les individus et les collectifs peut être utilisé à des fins d’émancipation, dans une logique « contre-fictionnelle » (Citton, 2010 ; Revue Multitudes 2012), qui mobilise le « pouvoir de scénarisation » afin de revendiquer notre imaginaire captif. En huit numéros publiés entre 2008 et 2011, la revue de « Littératures » TINA a été un laboratoire où ont convergé ces deux formes de critique, artiste et sociale, du storytelling (et plus largement du néolibéralisme dont il est indissociable). C’est ce corpus que nous nous proposons d’analyser dans cette communication. Contre le double constat d’une « désertification de l’espace littéraire » (éditorial du numéro 1) et d’une certaine désaffection de l’extrême-gauche pour la littérature (Quintane, 2014), TINA a renoué avec une conception exigeante de la littérature comme « lieu de tous les savoirs » et de la fiction comme territoire à part entière où explorer des enjeux politiques et sociaux. Sous quelles formes cette convergence entre création littéraire et critique des mondes contemporains s’est-elle manifestée ? Quel jeu de prises ou d’arguments peut-on dégager des nombreux dispositifs expérimentés par la revue, entre la première partie, explicitement fictionnelle, de chaque numéro, et la seconde, centrée sur des « dossiers » (« territoires », « capitalismes », « argent », « Gender surprise », etc.) ? Enfin, quels acteurs (écrivains, artistes, philosophes, sociologues) ont participé à cette aventure qui marque aussi, sous une forme atténuée, le retour d’une certaine logique collective défensive, générationnelle ou groupale (également perceptible au sein du collectif Inculte), dans un champ littéraire de plus en plus menacé dans son autonomie. [less ▲]

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See detailVitamine D et Vitamin D Binding protein
VRANKEN, Laura ULiege

Conference (2017, September 28)

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See detailLe Stress Oxydant: arnaque ou biologie d'avenir?
LE GOFF, Caroline ULiege

Conference (2017, September 28)

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See detailLa critique dans l'université contemporaine. Responsabilité et complexité.
Bachelet, Jean-François ULiege

Conference (2017, September 28)

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See detailPrevenzione quaternaria, primum non nocere
Jamoulle, Marc ULiege

Conference (2017, September 28)

When presented in Durham during the 1995 WICC workshop, the concept of quaternary prevention, born in 1986, has attracted the consensus of the whole audience. In 2003 it has been discretely published in ... [more ▼]

When presented in Durham during the 1995 WICC workshop, the concept of quaternary prevention, born in 1986, has attracted the consensus of the whole audience. In 2003 it has been discretely published in the Wonca dictionary of general practice. Since this time, medicine has changed. The diffusion of knowledge and the sagacity of some researchers has shown that medicine could become dangerous for health. The concepts of overinformation, overdiagnosis, overtreatment and overscreening are now the bread and butter of numerous medical journals and the themes of numerous books and disputes throughout the world. Quaternary prevention encompasses all those domains and supersedes them by putting the relationships between patient and doctor at the center of the ethical reflection. WICC has been instrumental in the genesis and dissemination of the concept of quaternary prevention. This concept is now known and distributed worldwide under the acronym P4. Family physicians form interlinked P4 groups in various countries. It is the theme of many congresses and was propelled to the forefront of the recent Wonca Europe Congress. This concept could induce profound changes in the role of the family physician in health care. Moreover, the combination of the four definitions of prevention provided an amazing view of the activity of family physicians and could renew basic job description in GP / FM. [less ▲]

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See detailA mathematical model of respiration under protective ventilation and extracorporeal CO2 removal therapy
Habran, Simon ULiege; Desaive, Thomas ULiege; MORIMONT, Philippe ULiege et al

Conference (2017, September 27)

The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency. The model must ... [more ▼]

The aim of the present study is to build a mathematical model of the respiratory system connected to an extracorporeal CO2 removal device (ECCO2RD) to optimize the gas exchanges efficiency. The model must be simple enough to provide rapid solutions and to estimate specific parameters from available clinical data. But it also must be complex enough to be able to simulate the respiratory system when protective ventilation is used and when this system is assisted by an ECCO2RD. [less ▲]

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See detailLes expériences de mort imminente: le point de vue des neurosciences
Martial, Charlotte ULiege

Conference (2017, September 27)

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See detailDe la R&D à la mise sur le marché de produits industriels, évolutions de la recherche au service des entreprises
Blecker, Christophe ULiege

Conference (2017, September 26)

Ce séminaire retrace par des exemples concrets de développement de produits l'évolution des interactions entre le secteur alimentaire et la recherche fondamentale et appliquée. L'objectif est de mettre en ... [more ▼]

Ce séminaire retrace par des exemples concrets de développement de produits l'évolution des interactions entre le secteur alimentaire et la recherche fondamentale et appliquée. L'objectif est de mettre en avant l'apport de certaines méthodes de travail pour obtenir un partenariat entreprises-centres de recherche optimal. Pour conclure, il présente les principaux résultats de recherche dont son domaine dont les entreprises pourraient trouver un intérêt. [less ▲]

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See detailLes interactions enseignant/enfants comme soutien au développement langagier des enfants en classe maternelle
Leroy, Sandrine ULiege; Bergeron-Morin, Lisandre ULiege; Desmottes, Lise ULiege et al

in Les entretiens de Bichat : les entretiens d'orthophonie 2017 : Les pathologies du langage chez l'enfant de moins de 6 ans: facteurs de risque (FR), facteurs de protection (FP) (2017, September 22)

L'école maternelle constitue un contexte privilégié pour soutenir le développement du langage et de la communication des enfants. La qualité des interactions entre l’enseignant et les enfants de sa classe ... [more ▼]

L'école maternelle constitue un contexte privilégié pour soutenir le développement du langage et de la communication des enfants. La qualité des interactions entre l’enseignant et les enfants de sa classe est reconnue comme étant l’aspect le plus déterminant de la qualité éducative, notamment en ce qui concerne le développement langagier. Cet article a pour objectif de faire un survol de la littérature sur le développement du langage des enfants en contexte préscolaire, sur le rôle que peut y jouer l’enseignant, ce qui ouvre des perspectives quant aux modalités de développement professionnel des enseignants en maternelle. [less ▲]

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See detailConférence d'ouverture : La morale de 1964 : une écriture en débats
Cormann, Grégory ULiege; Bourgault, Jean

Conference (2017, September 22)

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See detailMyoferlin controls mitochondrial structure in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness
Rademaker, Gilles ULiege; Hennequière, Vincent ULiege; Brohée, Laura ULiege et al

Poster (2017, September 22)

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on ... [more ▼]

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on classical chemotherapies. Cell fraction can survive to the chemotherapy and is responsible for tumor relapse. It appears that these cells rely on OXPHOS for survival. Myoferlin, a membrane protein involved in cell fusion was recently shown by our laboratory to be overexpressed in pancreatic cancer. In the present study, we discovered that myoferlin was more expressed in cell lines undergoing oxidative phosphorylation (OXPHOS) than in glycolytic cell lines. In the former cell lines, we showed that myoferlin silencing reduced OXPHOS activity and forced cells to switch to glycolysis. The decrease in OXPHOS activity is associated with mitochondrial network disorganization. Dynamin-related protein (DRP)-1 phosphorylation led us to suggest mitochondrial fission, reducing cell proliferation, ATP production and inducing autophagy and ROS accumulation. To confirm the clinical importance of myoferlin in PDAC, we showed that low myoferlin expression was significantly correlated to high overall survival. Myoferlin staining of PDAC sections was negatively correlated with several 18FDG PET indices indicating that glycolytic lesions had less myoferlin. As the mitochondrial function is demonstrated to enhance the cell resistance to the treatment, the metabolic switch forced by myoferlin silencing could open up a new perspective in the development of therapeutic strategies. [less ▲]

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See detailSemantic externalism(s) and cognitive transparency
Leclercq, Bruno ULiege; De Brabanter, Philippe

Conference (2017, September 22)

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See detailPsychological Predictors and Consequences of Hearing Health Behaviors in Older Adults
Marquet, Manon ULiege; Chasteen, Alison L; Plaks, Jason E et al

Poster (2017, September 22)

Introduction: Hearing loss is a common chronic condition affecting older adults in Western populations [1, 2]. Even if older adults could benefit from hearing aid use, they are reluctant to wear them [1 ... [more ▼]

Introduction: Hearing loss is a common chronic condition affecting older adults in Western populations [1, 2]. Even if older adults could benefit from hearing aid use, they are reluctant to wear them [1]. The purpose of the present study was twofold: a) to examine whether older adults’ implicit theories regarding the modifiability of abilities in general would predict their hearing health behaviors; and (b) to assess consequences of these behaviors on subjective aging. Methods: One hundred and sixty-three older adults (Mean age = 68.62, SD = 5.40) completed, among other questionnaires, questions assessing their implicit theories of ability (i.e., seeing general abilities as fixed vs. improvable with effort [3]) and their subjective age (i.e., felt age, do age, look age, and interest age [4]). They also reported their perceptions of the benefits of various hearing health behaviors for slowing the effects of aging (i.e., getting their hearing tested and using hearing aids) as well as their intentions to engage in those behaviors. Results: We found that the more older people considered that abilities are alterable, the more they perceived hearing health behaviors as being beneficial, which in turn increased their intentions to engage in these behaviors. Also, the greater their intentions, the younger subjective age they reported. Key conclusions: These relationships between implicit theories, hearing health behaviors, and subjective age are particularly important to take into account. Indeed, neglecting hearing problems and experiencing an older subjective age may have detrimental health-related outcomes over time [5, 6]. 1. Feder, K., Michaud, D., Ramage-Morin, P., McNamee, J., & Beauregard, Y. (2015). Prevalence of hearing loss among Canadians aged 20 to 79: Audiometric results from the 2012/2013 Canadian Health Measures Survey. Health Reports, 26(7), 18-25. 2. Lin, F. R., Thorpe, R., Gordon-Salant, S., & Ferrucci, L. (2011). Hearing loss prevalence and risk factors among older adults in the United States. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 66(5), 582-590. doi: doi:10.1093/gerona/glr002 3. Dweck, C. S. (1999). Self-theories: Their role in motivation, personality, and development. Philadephia, PA: Psychology Press. 4. Kastenbaum, R., Derbin, V., Sabatini, P., & Artt, S. (1972). “The ages of me”: Toward personal and interpersonal definitions of functional aging. The International Journal of Aging and Human Development, 3(2), 197-211. 5. Bainbridge, K. E., & Wallhagen, M. I. (2014). Hearing loss in an aging American population: Extent, impact, and management. Annual Review of Public Health, 35, 139-152. doi: 10.1146/annurev-publhealth-032013-182510 6. Kotter-Grühn, D., Kornadt, A. E., & Stephan, Y. (2015). Looking beyond chronological age: Current knowledge and future directions in the study of subjective age. Gerontology, 62(1), 86-93. doi: 10.1159/000438671 [less ▲]

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See detailTowards a covering aerospray method for quantitative analyses of pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI)
Cailletaud, Johan ULiege; De Bleye, Charlotte ULiege; Dumont, Elodie ULiege et al

Conference (2017, September 22)

In recent years, the use of SERS-CI in pharmaceutical sciences has increased in order to study the distribution of low-dose compounds in solid dosage forms [1]. This technique allows to improve the ... [more ▼]

In recent years, the use of SERS-CI in pharmaceutical sciences has increased in order to study the distribution of low-dose compounds in solid dosage forms [1]. This technique allows to improve the sensitivity of conventional Raman microscopy and to reduce significantly the image acquisition time by exalting the signal information. However, the applications of SERS-CI in the pharmaceutical field remain limited, especially due to the difficulty of obtaining a homogeneous deposit of metallic nanoparticles on the sample surface. Generally, the covering method used on the tablet is a drop casting deposition due to its simplicity and rapidity of implementation. Despite the colloidal solution deposit is not fully controlled. The inhomogeneous covering is the result of the “coffee-ring” effect that concentrates the nanoparticles at the edges of the droplet [2]. This implies remarkable variations of the SERS analyte signal’s intensity at different places. For a more reproducible and homogeneous coating, an aerospray method using a homemade apparatus was developed (Figure 1). The device is composed with a pair of coaxial tubes, the colloidal solution is pulled through the inner tube from a syringe pump and the outer tube is connected to a source of high pressure gas. Nitrogen, used as a nebulizing gas, creates a flow of small droplets of nanoparticles that are nearly dry when they hit the sample surface. The aerospray device is easy to implement and the entire surface of the tablet is covered by the SERS substrate in a homogeneous way. By using this covering method, the potential of SERS-CI is improved and making it a suitable technique for quantitative analyses of low drug concentrations or impurities in pharmaceutical tablets. [less ▲]

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See detailAgeism and dementia stigma among healthcare professionals
Schroyen, Sarah ULiege; Adam, Stéphane ULiege; Missotten, Pierre ULiege

Poster (2017, September 21)

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See detailFacultative paedomorphosis in pond-breeding newts
Denoël, Mathieu ULiege

Conference (2017, September 21)

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See detailEffect of solution treatment on the fracture mechanisms of AlSi10Mg parts produced by Selective Laser Melting
Delahaye, Jocelyn ULiege; Mertens, Anne ULiege; Dedry, Olivier ULiege et al

Poster (2017, September 21)

Al alloy AlSi10Mg processed by Selective Laser Melting (SLM) displays high hardness and tensile strength due to its very fine eutectic microstructure [1]. However, as-built material exhibits low ductility ... [more ▼]

Al alloy AlSi10Mg processed by Selective Laser Melting (SLM) displays high hardness and tensile strength due to its very fine eutectic microstructure [1]. However, as-built material exhibits low ductility which is detrimental for applications where a high resilience is needed. To overcome this issue, solution heat treatment can be applied to soften and ductilize the material [2]. The very fine eutectic microstructure then turns into a dispersion of coarse globular Si precipitates. The distribution of Si precipitates seems to play a role in the fracture mechanism in as-built as well as solutionized tempers, but this effect is not yet fully understood [1,3]. Moreover, the lack of quantitative data makes it difficult to link precisely the fracture mechanisms to specific microstructural features. This study aims at investigating the role of the Si phase in the rupture mechanism, for both as-built and solutionized samples. It will focus more particularly on the heterogeneity of the distribution of Si precipitates where cracks are more likely to occur. Al cells size, along with the volume fraction and distribution of Si precipitates have been quantified by SEM image analysis. Al lattice parameter and Si crystallite size have been determined by X-ray diffraction/Rietveld analysis. For the image analysis, two types of specific zones have been observed i.e. the core and boundary of melt pools and Al grains, at different locations for representativity. These quantitative data have been compared with typical features observed on the fractured surface of tensile specimen. 1. D.-K. Kim et al. J. Alloys Compd. 686 (2016) 281. 2. W. Li et al., Mat. Sci. & Eng. A. 663 (2016) 116, 3. N.T. Aboulkhair et al. Mat. Sci. & Eng. A. 667 (2016) 139. [less ▲]

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See detailHealing effect of controlled anti-electromigration on conventional and high-Tc superconducting nanowires
Baumans, Xavier ULiege; Lombardo, Joseph ULiege; Brisbois, Jérémy ULiege et al

Conference (2017, September 21)

At the present time, electron beam lithography (EBL) is considered as the reference technique for nanoscale patterning. However, making nanostructures below the sub-10 nm scale is still challenging due to ... [more ▼]

At the present time, electron beam lithography (EBL) is considered as the reference technique for nanoscale patterning. However, making nanostructures below the sub-10 nm scale is still challenging due to broadening effects (forward electron scattering, backscattering, electrostatic charging…), and requires strong investment in terms of cost for state-of-the-art EBL systems. In this sense, alternative methods are continuously explored in order to make such nanofabrication easily reachable. A promising approach consists of inducing atomic diffusion by a large current density. This phenomenon, called electromigration (EM), and well known since the 60’s as a failure mechanism in metallic interconnections [1], still attracts interests from scientists and engineers for its great potential for fabrication of microstructures and for its reversibility character [2, 3]. In this work, we show that the combination of electromigration and anti-electromigration allows the precise tuning of superconducting properties of Al nanoconstrictions and we also observe the reversibility of electromigration failure for this material (see Fig. 1). The same process has been applied on Nb, leading to a more irreversible process, and La2 xCexCuO4. For the latter material, we show that selective migration of oxygen atoms and the consequent doping modification induces a transition from a superconducting state to an insulating state in a reversible way [4]. We also discussed the possibility to enhance the electromigration technique by replacing the complex feedback control by a technique of electropulsing. These researches have direct practical impact as a method to explore the dependence of the characteristic parameters on the exact oxygen content and pave the way for a reversible control of local properties of nanowires. [less ▲]

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See detailQuelques pistes pour relancer la foresterie sociale et la participation en Afrique centrale
Vermeulen, Cédric ULiege

Conference (2017, September 21)

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See detailPerformance-based fire design and the U.S. prescriptive guidelines: A comparative study
Elhami Khorasani, Negar; Fang, Chenyang; Gernay, Thomas ULiege

in Proceedings of the 39th IABSE Symposium (2017, September 21)

Current codes and standards for fire design of structures in the United States are mainly based on design at the component level using prescriptive approaches, while performance-based design for fire can ... [more ▼]

Current codes and standards for fire design of structures in the United States are mainly based on design at the component level using prescriptive approaches, while performance-based design for fire can be used to address the needs for designing modern buildings with cost-effective solutions. Previous research shows that, when system-level performance is considered, fire protection on secondary beam elements in composite steel-concrete floor systems is not necessary due to the development of a membrane action in the concrete slab during fire. This study compares the fire design of a 9-story office building using prescriptive and performance-based designs. The safety levels of the two designs are investigated and compared. It is shown that performance-based design can be used to achieve the required level of safety currently enforced in the U.S. prescriptive guidelines, while providing an opportunity for cost reduction in fire protection material. [less ▲]

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See detailTowards the development of a dual mode fluorescence/SERS dopamine aptasensor
Dumont, Elodie ULiege; De Bleye, Charlotte ULiege; Cailletaud, Johan ULiege et al

Poster (2017, September 21)

This work was dedicated to the development of a dual mode fluorescence and surface-enhanced Raman scattering (SERS) dopamine aptasensor. The preparation of the aptasensor was first optimised. Thereafter ... [more ▼]

This work was dedicated to the development of a dual mode fluorescence and surface-enhanced Raman scattering (SERS) dopamine aptasensor. The preparation of the aptasensor was first optimised. Thereafter, calibration curves were realised by means of fluorescence quenching and SERS. Finally, the specificity of both methods was tested. [less ▲]

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See detailÉmile de LAVELEYE (1822-1892) et le « bon » gouvernement
Grandjean, Geoffrey ULiege

Conference (2017, September 20)

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See detailLegitimating innovation by foreign traditions: the case of the Roman Republican divination
Berthelet, Yann ULiege

Conference (2017, September 20)

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See detailWP1 - A summary
Sanchez, Christelle ULiege

Conference (2017, September 20)

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Peer Reviewed
See detailIdentification and quantitation of intact virus-like particles of human papillomavirus (HPV-VLP) using capillary electrophoresis
Bettonville, Virginie ULiege; Nicol, Jérôme; Furst, Tania et al

Conference (2017, September 19)

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See detailThe Cassini-Huygens mission: tale of a 13-year journey in the Saturnian system
Palmaerts, Benjamin ULiege

Conference (2017, September 19)

On the 15th of September 2017, the Cassini spacecraft will plunge into the atmosphere of Saturn, making the end of the successful Cassini-Huygens mission. During this unprecedented mission, Cassini will ... [more ▼]

On the 15th of September 2017, the Cassini spacecraft will plunge into the atmosphere of Saturn, making the end of the successful Cassini-Huygens mission. During this unprecedented mission, Cassini will have spent 13 years around Saturn, achieving almost 300 orbits around the planet and continuously collecting observations of Saturn, its rings, moons and space environment. In this talk, after a short introduction about the genesis of the Cassini mission, I will give a review of all the important results of the mission. The dynamics of Saturn's atmosphere and magnetosphere will be discussed, as well as the discoveries about the evolution of the rings. An important part of the presentation will be also devoted to the moons Titan and Enceladus which both exhibit striking characteristics. [less ▲]

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See detailChallenges in the determination of amyloid oligomeric species by two electrophoretic techniques
Napp, Aurore ULiege; Houbart, Virginie ULiege; Demelenne, Alice ULiege et al

Poster (2017, September 18)

Parkinson’s disease is a frequent degenerative disorder, and for the moment the diagnosis is mainly clinical. When the first symptoms appear, loss of more than 70% of the dopaminergic cells already ... [more ▼]

Parkinson’s disease is a frequent degenerative disorder, and for the moment the diagnosis is mainly clinical. When the first symptoms appear, loss of more than 70% of the dopaminergic cells already occurred. Knowing that, it is of high interest to have one (or more) reliable biomarker(s) at our disposal to diagnose Parkinson before the first symptoms appear. Alpha-synuclein (aSyn) is a protein physiologically expressed at high level by neuronal cells, under a monomeric form. This protein would play a critical role in the development of the disease because under certain conditions, aSyn is capable of self-assembly to form fibrils like those found in Lewy bodies. Other intermediate soluble forms like dimers and oligomers are also formed. As these forms seems to be the toxic species, they are the center of many attentions. The quantification of each form would be a great help, but for the moment only the total forms (of monomeric or oligomeric) can be quantified. In this study, aSyn oligomers were generated after optimization of incubation conditions (pH, temperature, agitation, …). Then, different approaches were investigated to detect and follow the different species formed during the aggregation. We analyzed the oligomers by capillary gel electrophoresis (CGE) and SDS-PAGE. We found that capillary gel electrophoresis is a promising automated technique to analyze aSyn oligomers, due to the fact that it separates the aggregates according to their size, like the SDS-PAGE, but with more advantages. To gain sensitivity and selectivity by CGE, we used a laser-induced fluorescence detector. As aSyn do not have a native fluorescence, we derivatized it. After careful screening and optimization of various derivatization reagents, we could quantify with high sensitivity aSyn oligomers by CGE-LIF. We realized different calibration curves, and we had promising results that will allow us to quantify the different aSyn oligomeric forms in biological fluids. [less ▲]

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See detailMusic in the Operating Room
XHAUFLAIRE, Gaël ULiege; Albert, Louisa; Gengoux, Monique

Poster (2017, September 15)

Listening to music during surgery has a subjective benefit to patients under local anesthesia. Its setting up during quiet routine oculoplastic surgery is easy and inexpensive. When subject to some ... [more ▼]

Listening to music during surgery has a subjective benefit to patients under local anesthesia. Its setting up during quiet routine oculoplastic surgery is easy and inexpensive. When subject to some elementary precautions, there is no increased risk. [less ▲]

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See detailFatigue resistant designs using stress-based topology optimization
Collet, Maxime ULiege; Bauduin, Simon ULiege; Fernandez Sanchez, Eduardo Felipe ULiege et al

Conference (2017, September 15)

Fatigue is an important mode of failure in mechanical engineering and accounting for it as soon as the early stage of design using topology optimization sounds primordial. Structures undergoing high-cycle ... [more ▼]

Fatigue is an important mode of failure in mechanical engineering and accounting for it as soon as the early stage of design using topology optimization sounds primordial. Structures undergoing high-cycle fatigue can be described by the stress-based approach and then a stress-based topology optimization framework, which has received great interest since almost 20 years because of the innovative designs that can be achieved to answer strength requirements, can be used. Literature reports many good results for shape optimization [Mrzyglod & Zielinsky(2006)] whereas in the eld of topology optimization several authors have shown that considering fatigue in an optimization framework leads to more relevant solutions where fluctuating loads are involved [Holmberg E.(2015), Collet et al(2016), Sv ard(2015)]. The good behaviour of the implementation of an advanced fatigue criterion, i.e. the multiaxial Dang Van criterion [Dang Van et al(1989)] is first investigated in the framework of a density-based topology optimization problem. The choice of this fatigue criterion is justifed by its good applicability in automotive or aeronautic industry as well as its relevancy with respect to experimental results. We present the sensitivity analysis with stress constraints and present some classical benchmarks to illustrate the behaviour of the optimized solution. In a second time, the fatigue resistance is introduced in the well-known microstructural design [Sigmund (2000)] also know as architectured material design which are now considered in mechanical engineering because of their manufacturability thanks to additive manufacturing processes. Ensuring the fatigue resistance of the cellular material will by extension ensure the structural integrity of the overall structure itself. The optimization is performed by using the MMA optimizer [Svanberg(1987)] whereas the singularity phenomenon of the stress constraints is circumvented by using the qp-relaxation [Bruggi(2008)]. Both types of optimization framework are evaluated in term of their numerical performances and are compared to classical results generated by a regular stress-based topology optimization. Finally, the results are 3D-printed to assess for their manufacturability. [less ▲]

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See detailRuralité et mondialisation dans l'oeuvre de Josef Winkler
Neelsen, Sarah ULiege

Conference (2017, September 15)

Une œuvre à ce point enracinée dans le paysage, la culture et la langue de l’Autriche semblait peu propice à intégrer les bouleversements de l’ordre mondial après 1989 et son auteur bel et bien enfermé ... [more ▼]

Une œuvre à ce point enracinée dans le paysage, la culture et la langue de l’Autriche semblait peu propice à intégrer les bouleversements de l’ordre mondial après 1989 et son auteur bel et bien enfermé dans une certaine tradition nationale. Pourtant à partir de 1996, les récits de voyage, journaux intimes et romans sur l'Inde se multiplient. La mondialisation semble donc bien avoir eu un impact profond sur son travail et l'étude approfondie du roman Roppongi montre comment se construisent des effets de résonance entre rituels funéraires hindous et catholiques. Cette communication analyse les différences entre interculturalité et mondialisation, lieux et non-lieux et conclut sur la tension entre la mobilité des corps et l'obsession de l'image fixe. [less ▲]

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See detailHow classroom teachers do take the ‘Physical Activity Pauses at School’ (PAPS)? A project implemented in Wallonia
Cloes, Marc ULiege; Cloes, Stéphanie

Conference (2017, September 15)

In Wallonia, special efforts are needed in order to respect the international recommendations on physical activity in youth. School is definitely considered as a central pillar in the promotion of an ... [more ▼]

In Wallonia, special efforts are needed in order to respect the international recommendations on physical activity in youth. School is definitely considered as a central pillar in the promotion of an active lifestyle. The aim of this study was to analyze the implementation process of daily activity breaks called ‘Physical Activity Pause at School’ (PAPS) in 6 primary schools of the Liege area. 23 classroom teachers were involved. They had to propose at least one PAPS/day during the 15-16 school year. Diary, questionnaires, focus groups and interviews were used for data collecting. Two thirds of the subjects continued until the end. The videos were not systematically used. Four teachers’ profiles were identified: Innovators, Invested, Careful, and Disengaged. 12 factors facilitating or limitating the involvement of the teachers have been analyzed. The study comes to a model of concrete actions to respect in order to increase the chances of success in the implementation of such project. [less ▲]

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See detailSharing good practices in physical education to promote physical activity, wellness and health
Bonni, Jérémy ULiege; Cloes, Marc ULiege

Poster (2017, September 15)

The Wallonia-Brussels Federation is about to overhaul its education system, which will directly affect teacher training. Under the “Pact for Excellence in Education”, a group of experts – the Consortium ... [more ▼]

The Wallonia-Brussels Federation is about to overhaul its education system, which will directly affect teacher training. Under the “Pact for Excellence in Education”, a group of experts – the Consortium “Physical Activities, Well-Being and Health” – drawn from the 12 French-speaking institutions training PE teachers (universities and colleges) has been mandated by the Ministry of Education to design devices and tools aiming at implementing the new common core curriculum that is under construction. Good practices have been identified then described in information sheets common to the different consortiums of the PEE and listed in a table that cross-references the 6 dimensions of physical activity at school (Snyers et al., 2014) and the 20 objects of teaching-learning in health education (Turcotte et al., 2011). These good practices are meant to be shared later within a community of practice. This paper provides a description of one of these information sheets in order to illustrate the methodology applied in this project. [less ▲]

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See detailIdentification of Signaling Pathways Regulating Beta Cell Regeneration in Zebrafish
Massoz, Laura; Bergemann, David ULiege; Lavergne, Arnaud ULiege et al

Conference (2017, September 15)

Diabetes is becoming a leading health issue worldwide. It occurs under insulin resistance/deficiency and when insulin-producing pancreatic beta-cell mass is dramatically reduced. Besides therapeutic ... [more ▼]

Diabetes is becoming a leading health issue worldwide. It occurs under insulin resistance/deficiency and when insulin-producing pancreatic beta-cell mass is dramatically reduced. Besides therapeutic strategies to preserve beta-cell mass and function and improve insulin treatments, beta-cell replacement constitutes a promising alternative to replenish the pancreas with functional beta-cells. Beta-cell neogenesis can be achieved from different pancreatic cell types leading to the hope that triggering regeneration could be harnessed in future therapies. Still, mammals show limited regenerative capabilities, making difficult the study of these mechanisms. In contrast, zebrafish is extensively used for regeneration studies notably of beta-cells. We recently showed that the adult zebrafish ducts display characteristics of embryonic pancreatic progenitors that give rise to beta-cells in physiological and induced diabetic condition*. To better understand the molecular mechanisms underlying this potential, genes and signaling pathways regulated in the zebrafish pancreatic ducts after beta-cell ablation have been identified by transcriptomic profiling. For functional studies, we have developed an assay using 7-20 days old larvae to investigate the role of selected candidate pathways in beta-cell regeneration with pharmacological inhibitors/activators and by transgenic overexpression of candidate signaling factors. These results should provide new hints to help improve regenerative competences in mammals. [less ▲]

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See detailModélisation des mécanismes psychologiques du processus de radicalisation
Garcet, Serge ULiege

Conference (2017, September 14)

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See detailLes documents d'urbanisme. Vers quel typologies de représentation sous le paradigme du BIM ?
Boutemadja, Abdelkader ULiege

Conference (2017, September 14)

Sous le nouveau paradigme du BIM et du SIG 3D, quel typologies de représentation graphique doivent adopter les documents d'urbanisme. Il s'agit d'une reflexion qui donne à entrevoir les possibilités de ... [more ▼]

Sous le nouveau paradigme du BIM et du SIG 3D, quel typologies de représentation graphique doivent adopter les documents d'urbanisme. Il s'agit d'une reflexion qui donne à entrevoir les possibilités de représentation qu'offrent les nouvelles technologies. [less ▲]

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See detailToward discovery of novel key genes for pancreatic beta cell regeneration in zebrafish
Carril Pardo, Claudio Andrès ULiege; Bergemann, David ULiege; Massoz, Laura ULiege et al

Poster (2017, September 14)

Diabetes is becoming a leading health issue worldwide. It occurs under insulin resistance/deficiency and when insulin-producing pancreatic beta-cell mass is dramatically reduced. Besides therapeutic ... [more ▼]

Diabetes is becoming a leading health issue worldwide. It occurs under insulin resistance/deficiency and when insulin-producing pancreatic beta-cell mass is dramatically reduced. Besides therapeutic strategies to preserve beta-cell mass and function and improve insulin treatments, beta-cell replacement constitutes a promising alternative to replenish the pancreas with functional beta-cells. Several observations of pancreatic cell plasticity has led to the hope that triggering beta-cell regeneration within the pancreas could be harnessed in future therapies. Still, mammals show limited regenerative capabilities, making difficult the study of these mechanisms. In contrast, zebrafish is extensively used for regeneration studies notably of beta-cells. We recently showed that the adult zebrafish ducts display characteristics of embryonic pancreatic progenitors that can give rise to beta-cells in physiological and induced diabetic condition*, and we determined the transcriptomic profile of zebrafish pancreatic ducts during beta-cell regeneration. To identify new genes crucial for beta-cell regeneration we plan to investigate the role of about 10 selected candidate genes by analyzing invalidating mutations created by CRISPR/Cas9. Their effect on beta-cell regeneration will be studied in 7-20 old larvae which we have established as experimental platform for functional studies. This project should help decipher the molecular mechanism of beta-cell regeneration. [less ▲]

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See detailExecutive functions in normal aging: the mediating effect of processing speed and attentional system
Gilsoul, Jessica ULiege; Simon, Jessica ULiege; Collette, Fabienne ULiege

Poster (2017, September 14)

Objective The normal aging is associated with decrease in executive functioning efficiency. However, the source of these cognitive difficulties could reside in some factors that are not executive per se ... [more ▼]

Objective The normal aging is associated with decrease in executive functioning efficiency. However, the source of these cognitive difficulties could reside in some factors that are not executive per se. Therefore, this present study is aimed at determining whether speed of processing and attentional variables would mediate the effect of age on the executive functioning. Participants and Methods Young (n = 104) and old (n = 63) participants were enrolled and carried out a large battery made of 21 executive (inhibition, shifting, working memory updating, and double task coordination), attentional (phasic alertness, selective attention, and sustained attention), and processing speed tasks. Based on Baron & Kenny’s recommendations (1986), mediation models of the age effect on the executive functioning were carried out with processing speed and attentional system taken as mediators. Results Selective attention significantly mediated the effect of age on working memory updating [􀇻R2 = 7%, p < .001]. Moreover, processing speed significantly mediated the effect of age on shifting [􀇻R2 = 7%, p < .001], working memory updating [􀇻R2 = 5%, p < .001], and double task coordination [􀇻R2 = 14%, p < .001]. Conclusions The mediating effect of age on most of the executive functions by measures of processing speed is in agreement with the literature showing a major influence of the slowdown of the processing speed on cognition (Salthouse, 1992; 2000; 2005). The age effect on inhibition did not seem to be mediated neither by the attentional variables nor the speed variables, which is in accordance with Zacks & Hasher’s hypothesis (1988). According to these authors, inhibition would be the first cognitive function to decline with age. [less ▲]

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See detailThe artistic patronage of Cardinal Charles II de Bourbon (1433-1488)
Laruelle, Anne-Sophie ULiege

Conference (2017, September 14)

As one of the most important political and religious figures of the mid-fifteenth century, Charles II de Bourbon (1433-1488) has not received the attention he deserves. Charles, archbishop of Lyon (1446 ... [more ▼]

As one of the most important political and religious figures of the mid-fifteenth century, Charles II de Bourbon (1433-1488) has not received the attention he deserves. Charles, archbishop of Lyon (1446), was made cardinal by the pope Sixtus IV in 1476. He was also an important courtier, and a confidant of King Louis XI of France, to whom he was related by marriage. Charles was present at the interview of Kings Louis XI and Edward IV of England in 1475 and in the signature of the peace treaty concluded between them, which formally ended the Hundred Years’ War. Among other posts, Charles held the governorship of Paris and was the head of the King’s Council. Grandson of John the Fearless and cousin to Charles the Bold, he also bore numerous connections with the Burgundian Court and the Southern Netherlands. This paper aims at re-appreciating the artistic patronage of the wealthy cardinal, in spite of the difficulties raised by the paucity of surviving artworks he commissioned. Charles was indeed an important patron, who founded a splendid funerary chapel in Lyon Cathedral, and had the archiepiscopal palace of Lyon built. The cardinal owned a lot of exceptional manuscripts, sculptures and tapestries. Due to his position, Charles may have influenced tastes of Louis XI for the arts, but also the future king Charles VIII’s (Charles de Bourbon was, along with Joan of Valois, Duchess of Bourbon and Edward of Westminster, godparent of the dauphin in 1470).Particular attention will be paid to his collection of tapestries, which have never received detailed analysis. Charles II de Bourbon’s arms (motto, initials, and his device of a flaming sword) appear on only three pieces today: “The Adoration of the Magi”, “The Three Coronations” (both preserved in Sens cathedral), and a scene from the “Story of Hercules” (Mobilier National, Paris). Woven with extremely high quality, probably in the Southern Netherlands, the cardinal’s tapestries are undoubtedly among the finest and most expensive pieces of the 15th century. [less ▲]

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See detailFrom Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK)
Arslan, Deniz ULiege; Schoumacher, Matthieu ULiege; Pirotte, Bernard ULiege et al

Poster (2017, September 14)

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population of industrialized countries. This blindness results from the deterioration of the macula, a small part of ... [more ▼]

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population of industrialized countries. This blindness results from the deterioration of the macula, a small part of the retina specialized for the high-acuity vision. Exudative AMD, called “wet”, is characterized by the formation of new blood vessels growing under the retina according to a process named choroidal neovascularization (CNV). Currently, the aetiology and pathogenesis of AMD remain unclear. Nevertheless, a recent metabolomics study performed on the serum of “wet” AMD patients and on a CNV murine model, that mimics the effect of “wet” AMD, have demonstrated that lactate level is clearly involved in the severity of the pathology as well as the relationship between lactate, CNV and AMD [1]. According to this result, we suggest a new therapeutic approach of AMD based on the normalization of blood lactate level. The modulation of the lactate plasma concentration by treatment of the animals with synthetic compounds and more specifically Pyruvate Dehydrogenase Kinase (PDK) inhibitors significantly decrease the CNV. PDK and its four isoforms (PDK1-4) regulate the activity of the pyruvate dehydrogenase complex (PDH), a mitochondrial enzyme that plays a major role in the metabolic pathway of glucose, by reversible phosphorylation. Starting from these results, development of new PDK inhibitors could open the way to innovative treatment opportunities in AMD disease. Different analogues of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide (fig.1) have been already synthetized and pharmacological evaluation is currently in progress. According to the results obtained, various pharmacomodulations will be investigated. [less ▲]

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See detailDevelopment of SERS nanosensors for the detection of small bioactive molecules by cellular analysis in complex matrices: Application to dopamine
Dumont, Elodie ULiege; De Bleye, Charlotte ULiege; Cailletaud, Johan ULiege et al

Conference (2017, September 13)

This communication reports the different steps undertaken in order to develop a new Surface-Enhanced Raman Scattering (SERS) nanosensor for the quantification of dopamine in the culture medium of PC-12 ... [more ▼]

This communication reports the different steps undertaken in order to develop a new Surface-Enhanced Raman Scattering (SERS) nanosensor for the quantification of dopamine in the culture medium of PC-12 cells. First, the synthesis of the SERS substrate, gold nanoparticles, and its characterization. Then the development of the method with the help of a design of experiments and the demonstration of the specificity of the method over other structurally related catecholamines. And finally, the implementation of the method on the culture medium of PC-12 cells, on an HEPES buffer having served to wash the cells and on the PC-12 cells. [less ▲]

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See detailFrom seed to vegetable and from vegetable to seed : constructing a right to existence
Hecquet, Corentin ULiege

Conference (2017, September 12)

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See detailComparaison de l'impact de deux méthodes d'apprentissage sur la sécurité d'administration des médicaments : stages cliniques versus simulation
Servotte, Jean-Christophe ULiege; Galerin, Catherine ULiege; Ghuysen, Alexandre ULiege et al

Conference (2017, September 12)

Introduction Drug administration is the act nurses most frequently do. However, 50% of errors occur during administration. The damage these errors causes to patients, results in excess mortality rates and ... [more ▼]

Introduction Drug administration is the act nurses most frequently do. However, 50% of errors occur during administration. The damage these errors causes to patients, results in excess mortality rates and health care costs, hence leading to a major public health problem. Therefore, it is advisable to consider the training of future nurses on the practice of this delicate act. The objective of this study is to evaluate the impact of teaching by simulation combined with the internship on the safety administration of intravenous drugs by nursing students, compared to just the internship alone. Material and method A selection of 99 students from the bachelors’ block two of the Namur-Liege-Luxembourg Higher Institute of Nursing met the inclusion criteria under consideration. They were divided into two groups, one experimental group which participated in a simulation session and a control group, the latter did not participate in the simulation session. At the start of the research, all students were assessed by an objective structured clinical examination (OSCE) with the theme of modifying infusion and syringe flow rates. They were also asked to complete a questionnaire concerning their knowledge and self-efficacy feeling related to drug administration. The experimental group then participated in the simulation sessions. The experimental group and the control group also went into four weeks of training in medical or surgical services before participating in the second stage of the study. The latter consisted of the same tests and questionnaires as stage one of the study. The evolution of the results of the two groups was first observed separately before being compared. Results The majority of the results shows that the simulation improves, in a way significantly more important than the clinical course, the acquisition of skills and knowledge, as well as the feeling of self-efficacy in drug administration. On the other hand, the assessment of the level of stress linked to drug administration and the professional attitude evaluated during the OSCE were not significantly more improved by the simulation than by the training alone (stress: p-value = 0.8269, professional attitude = 0.9857). Conclusions For the students in the experimental group, the simulation showed a positive impact on the skills, knowledge and feeling of self-efficacy associated with drug administration. Changes and continuation of the study would make it possible to go further in the generalization of results, in the evaluation of learning outcomes, and to attest to their sustainability. [less ▲]

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See detailInfluences of feeding behaviour and forage quality on diurnal methane emission dynamics of grazing cows
Blaise, Yannick ULiege; Andriamandroso, Andriamasinoro ULiege; Heinesch, Bernard ULiege et al

in Berckmans, Daniel; Keita, Keita (Eds.) Precision Livestock Farming ‘17 (2017, September 12)

This study aimed to evaluate diurnal methane (CH4) emission dynamics of grazing cattle and highlight their relationships with biotic factors such as the feeding behaviour as well as seasonal changes in ... [more ▼]

This study aimed to evaluate diurnal methane (CH4) emission dynamics of grazing cattle and highlight their relationships with biotic factors such as the feeding behaviour as well as seasonal changes in pasture characteristics. Existing methods to assess grazing ruminants’ daily CH4 emissions provide useful insights to investigate mitigation strategies relying on feeding and genetic selection. Nonetheless such methods based on tracer gases (SF6) or feeding bins equipped with sniffers (e.g. GreenFeed) can hardly cover diurnal CH4 emission fluctuations which can influence the accuracy of total CH4 production estimations. Previous studies in barns showed that emission dynamics strongly vary during post feeding time, leading to a possible bias in estimates of daily CH4 emissions as high as 100%. To investigate whether such fluctuations are also taking place on pasture, a portable device was designed with infrared CH4 and CO2 sensors measuring concentrations in the exhaled air at a high sampling rate (4 Hz). Six grazing dry red-pied cows were equipped with the device and motion sensors during runs of 24h to monitor CH4 and CO2 emissions and detect their feeding behaviours (grazing, rumination and other behaviours), respectively. This experiment was performed in summer and fall in order to cover seasonal changes in pasture forage quality. Methane emission was estimated from the CH4:CO2 concentration ratio and the metabolic CO2 production of the cows. As for barn studies, variations were observed in total daily CH4 emission due to the seasons and diurnal variations were also observed due to animal behaviours. Relationships between animal feeding behaviour and CH4 emissions patterns on pasture were also unravelled. [less ▲]

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See detailLiDAR aérien et autres nuages de points pour la cartographie multi-échelles
Poux, Florent ULiege; Neuville, Romain ULiege; Kasprzyk, Jean-Paul ULiege et al

Conference (2017, September 12)

Utilisation de nuage de points pour la cartographie 3D multi-échelles. Exemples d'utilisation et définition de workflows pour assurer l'interopérabilité lors de la fusion de données issues de différents ... [more ▼]

Utilisation de nuage de points pour la cartographie 3D multi-échelles. Exemples d'utilisation et définition de workflows pour assurer l'interopérabilité lors de la fusion de données issues de différents capteurs. [less ▲]

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See detailManaging and authenticating non-institutional users in Alma: two experiences
Brownlie, Helen; De Groof, Robert ULiege; Renaville, François ULiege

Conference (2017, September 12)

The management of patron information within Alma is primarily reliant on two systems – the creation and updating of patron information by an external system such as student management or HR systems or ... [more ▼]

The management of patron information within Alma is primarily reliant on two systems – the creation and updating of patron information by an external system such as student management or HR systems or internally within Alma itself. A recent survey of the Alma community indicated the majority of institutions utilize a mixture of these external and internal processes. In addition to providing access to affiliated staff and students more than 89% of institutions responded that they provided user accounts to non-affiliated users such as the general public, members of other academic institutions, alumni, etc. Providing authenticated access to library services for the latter group relies heavily on Alma for password management. This presentation will outline the processes in place at the University of Otago and at the University of Liège for managing and authenticating non-institutional users and the possible effect of Ex Libris' proposed changes to internal authentication. [less ▲]

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See detailSampling only 10 μL of whole blood to study the bioavailability of itraconazole formulations in rats
Kok, Miranda ULiege; Thiry, Justine ULiege; Evrard, Brigitte ULiege et al

Conference (2017, September 12)

Background Volumetric absorptive microsampling (VAMS) offers a unique opportunity to collect small and accurate quantities of biological fluids. This sampling technique is of great interest for volume ... [more ▼]

Background Volumetric absorptive microsampling (VAMS) offers a unique opportunity to collect small and accurate quantities of biological fluids. This sampling technique is of great interest for volume-limited samples and for the collection of multiple samples from the same animal. This serial sample collection may reduce the number of required study animals, thereby fulfilling the three Rs rule (refine, reduce, replace). Here, we demonstrate the applicability of VAMS to study the bioavailability of drug formulations in rats. Methods Four itraconazole-containing formulations were successively administered to rats with a wash-out period of one week. VAMS was used to collect 14 whole blood samples of only 10 μL each within a time frame of 48 hours after administration of the different drug formulations. Particular attention was paid to sample preparation and stability. The extraction of itraconazole and its main metabolite hydroxy-itraconazole was optimized to provide a high recovery and minimal matrix effects. A developed and validated LC–MS/MS method was used for the quantification of the two compounds. Pharmacokinetic profiles for the different formulations were constructed and compared. Results The stability of itraconazole and hydroxy-itraconazole in dried VAMS samples of whole rat blood could not be guaranteed for more than a day when the samples were stored at room temperature. However, samples were stable for at least two weeks when stored at -80°C after sample preparation. Differences in pharmacokinetic profiles were observed for the tested drug formulations. Whole blood concentrations of itraconazole and its main metabolite were significantly higher after administration of three in-house produced formulations compared to concentrations obtained with a commercially available product. Moreover, these in vivo results could be partly related to in vitro dissolution rates of the various formulations. Conclusions VAMS is an attractive approach for bioavailability studies. Due to the low blood volumes per sampling point, the same rats can be used to compare various drug formulations. Therefore, the number of required animals can be drastically reduced. Moreover, this helps to suppress the inter-individual variability and strengthens the validity of results. [less ▲]

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See detailA tiny magic drawing board to track the penetration of magnetic flux in superconductors
Silhanek, Alejandro ULiege

Conference (2017, September 11)

Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit ... [more ▼]

Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit cards and computer hard drives. Here we experimentally show that a similar principle can be applied for imprinting the trajectory of quantum units of flux (vortices), travelling in a superconducting film (Nb), into a soft magnetic layer of permalloy (Py). In full analogy with the magnetic drawing board, vortices act as tiny magnetic scribers leaving a wake of polarized magnetic media in the Py board. The mutual interaction between superconducting vortices and ferromagnetic domains has been investigated by the magneto-optical imaging technique. For thick Py layers, the stripe magnetic domain pattern guides both the smooth magnetic flux penetration as well as the abrupt vortex avalanches in the Nb film. It is however in thin Py layers without stripe domains where superconducting vortices leave the clearest imprints of locally polarized magnetic moment along their paths. In all cases, we observe that the flux is delayed at the border of the magnetic layer. Our findings open the quest for optimizing magnetic recording of superconducting vortex trajectories. [less ▲]

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See detailBuckling of steel plates at elevated temperatures: Theory of perfect plates vs finite element analysis
Maraveas, Chrysanthos ULiege; Gernay, Thomas ULiege; Franssen, Jean-Marc ULiege

in Proceedings of CONFAB'17 Conference (2017, September 11)

The local buckling capacity of fire exposed thin-walled steel cross sections is affected by the reduction in strength and stiffness due to elevated temperatures and the amplitude of the initial local ... [more ▼]

The local buckling capacity of fire exposed thin-walled steel cross sections is affected by the reduction in strength and stiffness due to elevated temperatures and the amplitude of the initial local imperfections. Several researchers have proposed design methods to calculate the capacity of the plates (i.e. web and flanges) that compose these steel members at elevated temperatures, but they used different shapes of steel plates (sides ratio a/b) and different amplitudes of local imperfections. This variability in hypotheses happens because there is no clear provision defining the numerical modeling procedure for fire design of steel plates in the codes (European or US). According to the theory of perfect plates, the critical load depends of the shape of the rectangular plate (e.g. the sides ratio a/b) and the corresponding buckling mode (number of half waves), the boundary and the loading conditions. This paper reviews the existing code provisions and compares the existing design models and their assumptions for thin-walled steel cross sections. Elements of the theory of perfect plates are presented. Parametric finite element analyses are then conducted on isolated steel plates at elevated temperatures to investigate the effect of the plate shape (a/b ratio) and imperfections (amplitude and number of half wave lengths). From the analysis, the governing parameter will be estimated (a/b vs imperfections) for simulation of isolated flanges and webs. Finally, recommendations for the numerical modeling of steel plates at elevated temperatures are proposed. [less ▲]

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