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See detailPsychological benefits of a multidisciplinary rehabilitation program after breast cancer
Leclerc, Anne-France ULg; FOIDART-DESSALLE, Marguerite ULg; Bury, Thierry ULg et al

Conference (2015, September 27)

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined ... [more ▼]

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined. However, the disease and its treatments are at the origin of many undesirable side effects such as fatigue, anxiety, weight gain and sleep disorders. The objective of this study is to determine the psychological benefits of a multidisciplinary rehabilitation program among women treated for breast cancer (on average six months after the end of the adjuvant radiotherapy or chimiotherapy). Material and methods : 122 patients were included into a control group (n = 61) and a treated group (n = 61). All participants were submitted to evaluations before the beginning of the trial and after three months. These evaluations included different questionnaires exploring the quality of life, anxiety, depression and various functions and other symptoms related to cancer (EORTC QLQ-C30, EQ-5D, STAI, HADS) and functional assessments. The control group has received no intervention unlike the treated group that received a three-month rehabilitation including supervised physical training (90 min) with three times a week and various psycho-educational sessions (120 min) once a week. Results : After three months, the health status (quality of life) (p < 0,0001), the functional role (p = 0,031), emotional state (p < 0,0001) and physical (p = 0,0045), cognitive (p = 0,0027) and social functions (p = 0,0018) improve significantly in the treated group. This observation also applies to symptoms of fatigue (p < 0,0001), insomnia (p < 0,0001), pain (p = 0,002), dyspnea (p = 0,009), loss of appetite (p = 0,04), anxiety (p < 0,0001) and depression (p < 0,0001) as well as physical parameters obtained through functional assessments. In the control group, these improvements do not appear. Conclusions : This study shows the feasibility and psychological benefits of such a multidisciplinary oncological rehabilitation program in women after their treatments for breast cancer. Additional studies are needed to know the optimal time of beginning (during treatments or after them) and the optimal management time for this support. [less ▲]

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See detailHypoxic ischemic encephalopathy : new insights in neuroprotection
VIELLEVOYE, Renaud ULg

Conference (2015, September 26)

Hypoxic-ischemic encephalopathy (HIE) is a major contributor to neonatal morbidity and mortality and is a common cause of disability with devastating impact on individuals and families. During the acute ... [more ▼]

Hypoxic-ischemic encephalopathy (HIE) is a major contributor to neonatal morbidity and mortality and is a common cause of disability with devastating impact on individuals and families. During the acute phase, HIE is initially characterized by an excitotoxic cascade with hypoxic membrane depolarization, cytotoxic edema, glutamate release and intracellular accumulation of calcium leading to necrotic cell death and production of proinflammatory cytokines through the NF-κB pathway. In a second phase, reperfusion leads to production of free radicals, activation of proteases and phospholipases, exacerbing the damage to cell membrane and DNA and mitochondrial dysfunction causing caspase mediated apoptotic cell death. In a third phase, growth factors and inflammatory cytokines produced during the early phase of HIE attempt to repair damage induced by hypoxia–ischemia. Although the utility of therapeutic hypothermia induced in the 6 hours following HIE in the reduction of death or major neurodevelopmental disability is now well established in the neonate with moderate or severe encephalopathy, almost half of these children still die or have abnormal outcomes [1]. Protocols attempting to optimize cooling with deeper hypothermia (33.5°C vs 32.0°C) and/or longer duration (72h vs 120h), as well protocols studying neuroprotective effect of late hypothermia (6-24h) or hypothermia for 33-35 week GA preterm babies are currently performed. Furthermore, experimental data suggest that hypothermia extends the duration of the therapeutic window [2] and that certain drugs given during this time may improve neuroprotection either additively or synergistically. Xenon is a noble gas with anaesthetic and neuroprotective properties. It inhibits NMDA receptor, promotes cell survival and induces the production of erythropoietin and vascular endothelial growth factor through the hypoxia inducible factor 1 alpha (HIF-1α) pathway. Data from experimental piglet models of hypoxia-ischemia (HI) demonstrate a synergy when Xenon is administered in combination with mild therapeutic hypothermia [3]. In the human newborn, a phase-1 trial recently established that breathing 50% Xenon for up to 18 hours with 72 hours of cooling was feasible, with no adverse effects seen with 18 months’ follow-up [4]. A monocentric phase-3 trial is currently under process in England. Melatonin is a remarkable natural antioxidant but also exhibits antiapoptotic and anti-inflammatory properties in vitro. In animal models, melatonin administration prior or after the onset of HI significantly reduced infarct volume demonstrating both prophylactic and therapeutic effect [5-6]. When combined with hypothermia, melatonin enhances neuroprotection by reduction of the H–I-induced increase in clinically relevant biomarkers in the deep grey matter of newborn piglets [7]. Clinical studies confirmed its safety profile and its ability to reduce biomarkers level of HI in the human newborn [8]. Recently, a randomized controlled trial showed that the combination of melatonin and hypothermia administered to infants with moderate-to-severe H–I brain injury was efficacious in reducing oxidative stress, neonatal seizures and MRI brain lesions as well as in improving neurological outcomes at 6 months of age [9]. Erythropoietin (EPO) and its receptor are expressed in the developing central nervous system and are required for normal brain development. EPO is up-regulated in umbilical cord blood from babies who have suffered HI, which may be an endogenous repair mechanism. In vitro and in vivo neuroprotection induced by EPO is achieved by several mechanisms such as direct neurotrophic effect, direct antioxidant effects, decreased inflammation or regulation between pro-apoptotic and anti-apoptotic factors. Safety profile of EPO administration during hypothermia for newborns with HIE has been established in Phase I trials [10]. In a randomized prospective pase-2 trial, repeated low-dose rEPO reduced the risk of disability for infants with moderate but not severe HIE at 18 months, without apparent side effects [11]. A double-blind randomized controlled phase-3 trial is currently performed in France. Allopurinol is a xantine-oxidase inhibitor. In high concentrations it also scavenges hydroxyl radicals and prevents free radical formation. Allopurinol provides neuroprotection in rat and piglets models of HIE. In the human, a systematic review and meta-analysis of three studies on 114 newborns did not reveal statistically difference in the risk of death or a composite of death or severe neurodevelopmental disability between groups [12]. It was hypothesized that postnatal allopurinol treatment started too late to reduce reperfusion-induced free radical surge. However, in a recent study, allopurinol given to mothers during labor with fetal hypoxia did not significantly lower neuronal damage markers in cord blood even if post hoc analysis revealed a potential beneficial treatment effect in girls [13]. Magnesium sulfate (MgSO4) is a naturally occurring NMDA receptor antagonist. MgSO4 given to mothers at risk for preterm birth is associated with a reduced risk of cerebral palsy and gross motor dysfunction in their children. Its role as an adjuvant to therapeutic hypothermia in the asphyxiated term infant remains unclear. A recent review of preclinical studies using MgSO4 in HIE highlights the inconsistent impact between studies related to a lack of temperature control during and after HI, along with variability in the dose, timing of treatment [14]. A metaanalysis of five randomized controlled trials that compared magnesium to control in newborns with HIE showed a significant improvement in short term outcomes but no difference in the composite outcome of death or moderate to severe disability at 18 months [15]. Other NMDA and AMPA antagonist such as topiramate and memantine also exhibited neuroprotective properties in animal models but safety and efficacy in the human newborn with HIE still needs to be clarified [16]. N-acetyl cysteine (NAC) acts as a glutathione precursor with antioxidant, antiapoptotic, and anti-inflammatory properties. In a piglet model of HIE, NAC reduced cerebral oxidative stress, reduced cerebral lactate accumulation and improved cerebral perfusion. When combined with hypothermia in the asphyxiated rodent, NAC decreased infarct volume, improved myelin expression and functional outcomes on a synergistic pattern. NF-κB inhibitors and NO synthase inhibitors are other therapeutic options currently under investigation in in vitro and in vivo preclinical studies. Moreover, recent research performed at the University of Liege also suggests that Estetrol (E4), an estrogen synthetized exclusively by the human foetus, has neuroprotective properties in a rat model of HIE. Translation to clinical use in humans still needs to be studied [17]. Several therapies have also been suggested in order to improve mechanisms of repair and regeneration observed after the HI insult. Growth factors such as BDNF, IGF-1, EGF or bFGF can improve cell viability, stimulate the growth of new neurons or promotes oligodendroglial differentiation and myelination. Recent advances in regenerative medicine suggest that stem cell transplantation may improve repair of the damaged brain after HIE through the replacement of dead cells as well as through the release of trophic factors [18]. Animal preclinical data are promising. However many questions need to be answered with well-designed controlled trials before clinical application in daily practice. References [1] Edwards AD et al. (2010) Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ. 340:c363. [2] O'Brien F et al. (2006) Delayed whole-body cooling to 33 or 35 degrees c and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. Pediatrics 117:1549–59. [3] Chakkarapani, E. et al. (2010) Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Ann. Neurol. 68, 330–341 [4] Dingley, J. et al. (2014) Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study. Pediatrics 133, 809–818 [5] Carloni, S. et al. (2008) Melatonin protects from the long-term consequences of a neonatal hypoxic–ischemic brain injury in rats. J. Pineal. Res. 44, 157–164 [6] Hutton, L.C. et al. (2009) Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomyscahirinus). Dev. Neurosci. 31, 437–451 [7] Robertson, N.J. et al. (2013) Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain 136, 90–105 [8] Fulia, G. et al. (2001) Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. Journal of Pineal Research; 31(4):343–349. [9] Aly, H. et al. (2015) Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. J. Perinatol. 35, 186–191 [10] Wu, Y.W. et al. (2012) Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics. Pediatrics 130, 683–691 [11] Zhu, C. et al. (2009) Erythropoietin improved neurologic outcomes in newborns with hypoxic–ischemic encephalopathy. Pediatrics 124, 218–226 [12] Chaudhari, T. and McGuire, W. (2012) Allopurinol for preventing mortality and morbidity in newborn infants with hypoxic–ischaemic encephalopathy. Cochrane Database Syst. Rev. 7, Cd006817 [13] Kaandorp, J.J. et al. (2015) Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial. Arch. Dis. Child Fetal Neonatal Ed. 100, F216–F223 [14] Galinsky, R. et al. (2014) Magnesium is not consistently neuroprotective for perinatal hypoxia-ischemia in term-equivalent models in preclinical studies: a systematic review. Dev. Neurosci. 36, 73–82 [15] Tagin, M. et al. (2013) Magnesium for newborns with hypoxic–ischemic encephalopathy: a systematic review and meta-analysis. J. Perinatol. 33, 663–669 [16] Wu, Q et al. (2015) Neuroprotective agents for neonatal hypoxic–ischemic brain injury. Drug Discovery Today. [17] Tskitishvili, E et al. (2014). Estetrol attenuates neonatal hypoxic–ischemic brain injury. Experimental Neurology, 261, 298-307. [18] Kelen, D and Robertson, NJ. (2010) Experimental treatments for hypoxic ischaemic encephalopathy. Early Human Development 86; 369–377. [less ▲]

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See detailPhysical benefits of a multidisciplinary rehabilitation program after breast cancer
Leclerc, Anne-France ULg; FOIDART-DESSALLE, Marguerite ULg; Bury, Thierry ULg et al

Poster (2015, September 26)

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined ... [more ▼]

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined. However, the disease and its treatments are at the origin of many undesirable side effects such as fatigue, anxiety, weight gain and decreased physical fitness. The objective of this study is to determine the physical benefits of a multidisciplinary rehabilitation program among women treated for breast cancer (on average six months after the end of the adjuvant radiotherapy or chimiotherapy). Material and methods : 122 patients were included into a control group (n = 61) and a treated group (n = 61). All participants were submitted to evaluations before the beginning of the trial and after three months. These evaluations included functional assessments (a maximal incremental exercise protocol on a cycle ergometer, flexibility by Sit and Reach Test and walking distance by Six-Minute Walk Test), anthropometric and body composition measurements (Body Mass Index and body fat percentage) and different questionnaires on quality of life, anxiety and other symptoms related to cancer. The control group has received no intervention unlike the treated group that received a three-month rehabilitation including supervised physical training (90 min) with three times a week and various psycho-educational sessions (120 min) once a week. Results : After three months, maximal oxygen consumption (p < 0,0001), maximal aerobic power (p < 0,0001), peak of ventilation (p < 0,0001) and time to exhaustion (p = 0,0055) during the maximal incremental exercise protocol improve significantly in the treated group. This observation also applies to flexibility (p < 0,0001), walking distance in six minutes (p < 0,0001) and different physical and psychological parameters obtained through questionnaires. In the control group, these improvements do not appear and a significant increase in body mass index (p = 0,032) and body fat percentage (p = 0,034) is observed while these data remain constant in the treated group. Conclusions : This study shows the feasibility and physical benefits of such a multidisciplinary oncological rehabilitation program in women after their treatments for breast cancer. Additional studies are needed to know the optimal time of beginning (during treatments or after them) and the optimal management time for this support. [less ▲]

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See detailEn tous quartiers ou j’ay esté. Le récit de pèlerinage de Georges Lengherand, mayeur de Mons (1486–1487)
Bruwier, Marie-Cécile; Docquier, Gilles; Marchandisse, Alain ULg

Conference (2015, September 25)

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See detailHabitants des petites villes et des villages face à la nature dans les paysages ordinaires
Vanderheyden, Vincent ULg

Conference (2015, September 25)

La recherche sur les perceptions paysagères dénigre souvent les paysages ordinaires, ces paysages modifiés par l’homme qui n’appellent pas à la protection. Pourtant, dans les régions de forte densité de ... [more ▼]

La recherche sur les perceptions paysagères dénigre souvent les paysages ordinaires, ces paysages modifiés par l’homme qui n’appellent pas à la protection. Pourtant, dans les régions de forte densité de population comme la Belgique, les paysages naturels sont rares ou inexistants, sans pour autant que la nature ait disparu des paysages ordinaires. Il est donc intéressant de se poser la question de la nature dans de tels paysages : à partir de quand un paysage est-il perçu comme naturel par ceux qui l’observent ou y vivent ? Les critères dépendent-ils du mode d’habiter (petite ville, village périurbain ou village rural) ou d’autres facteurs liés à la trajectoire biographique des gens ? Trois terrains d’études ont été retenus pour la recherche : la Wallonie picarde, l’Entre-Sambre et Meuse et l’Ardenne. Ces terrains offrent des paysages ruraux assez typés et suffisamment différenciés et éloignés des grandes agglomérations urbaines, hormis Tournai, ville d’envergure régionale. La Wallonie picarde présente des paysages de vastes plateaux agricoles limoneux au relief plan et peu élevé, occasionnellement surplombé de petites collines. L’Entre-Sambre-et-Meuse offre des paysages mixtes, alternant cultures, prairies et boisement dans un relief plus accidenté d’altitude moyenne. Enfin, l’Ardenne, troisième terrain, montre des paysages de hauts plateaux disséqués, dominés par les massifs forestiers et les pâturages. Ces terrains offrent un bel aperçu du continuum urbain-rural belge : de la petite ville en milieu rural au semis d’habitat très lâche du village ardennais, loin de l’habituelle dichotomie ville - campagne. Dans ces terrains, une approche empirique a été privilégiée. Nous y avons interviewé trois groupes de neuf étudiants (18-25 ans) d’un niveau d’éducation moyen (Bac +1 à Bac +3), non spécialistes en analyse du paysage, habitant dans de petites villes ou villages et un de leurs parents. Durant l’enquête, les personnes devaient classer des photos de paysages ruraux belges plus ou moins impactés par la présence de l’homme (habitat, cultures, éoliennes, pylônes, zones périurbaines) puis devaient motiver leur classement. Les entretiens ont été enregistrés, retranscrits et codés à l’aide d’un logiciel d’analyse qualitative. L’analyse de contenu montre des résultats contrastés. Un certain consensus indépendant du mode d’habiter semble se dégager concernant la présence d’éléments anthropiques récents, tels quel les éoliennes, les zones industrielles ou les pylônes électriques : cela participe à la dénaturation d’un paysage, avec une subtile nuance pour les éoliennes, où la symbolique positive écologique peut pour certains contrebalancer la perte de naturalité induite. Chez des personnes vivant dans un milieu plus urbanisé, le paysage naturel attire, car il change des habitudes de vie. Certains n’hésitent pas à qualifier un paysage de naturel pour peu qu’il contienne suffisamment de végétation, fusse une vaste étendue agricole dédiée à la monoculture. Chez des personnes vivant dans des milieux très ruraux par contre, on ne constate pas toujours la tendance inverse : même la petite ville voisine semble parfois trop urbanisée à leurs yeux pour y vivre. A leurs yeux, les paysages deviennent moins attractifs au fur et à mesure que la densité du bâti devient perceptible. Plus qu’une analyse du visuel, cette recherche montre également que les gens s’imaginent être dans le paysage, entendant les bruits ou ressentant une perte de convivialité à mesure que le paysage s’industrialise ou se remplit de maisons. [less ▲]

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See detailTools for Measuring a City’s Resilience in a Fire Following Earthquake Scenario
Elhami Khorasani, Negar; Gernay, Thomas ULg; Garlock, Maria

in Proceedings of IABSE Conference - Structural Engineering: Providing Solutions to Global Challenges (2015, September 25)

The paper provides a framework to evaluate the response of buildings in a community subject to fire following earthquake. First, a model is developed to determine the probability of ignition in buildings ... [more ▼]

The paper provides a framework to evaluate the response of buildings in a community subject to fire following earthquake. First, a model is developed to determine the probability of ignition in buildings of a community due to an earthquake. Second, fragility functions are developed for buildings subject to fire, to quantify the structural damage and the expected losses. The ignition model, combined with the fragility functions, can be implemented in a GIS based risk management platform to evaluate economical losses in a region from fire following an earthquake. [less ▲]

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See detailBaltic seagrass meadows as a sediment carbon sink
Jankowska, Emilia; Włodarska-Kowalczuk, Maria; Michel, Loïc ULg et al

Conference (2015, September 25)

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See detailPhysicochimie de la pollution atmosphérique
Mahieu, Emmanuel ULg

Conference (2015, September 25)

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See detailOn generalized Hölder spaces
Kreit, Damien; Nicolay, Samuel ULg

Conference (2015, September 24)

We introduce generalized pointwise Hölder spaces as the point wise version of generalized uniform Hölder spaces. These last ones can be seen as a special case of generalized Besov spaces.

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See detailMedicinal plants, malaria and biotechnology
Frederich, Michel ULg; Jansen, Olivia ULg; Muganga, Raymond et al

Conference (2015, September 24)

The first part of the talk will be dedicated to the investigation of medicinal plants with the objective to identify new antimalarial treatments. According to the last World Malaria Report [1], there were ... [more ▼]

The first part of the talk will be dedicated to the investigation of medicinal plants with the objective to identify new antimalarial treatments. According to the last World Malaria Report [1], there were 584 000 deaths for 198 millions malaria cases worldwide in 2013. Particularly, the disease caused an estimated 437 000 African children died before their fifth birthday, still in 2013. Malaria is caused by a parasite, Plasmodium sp. and transmitted by Anopheles mosquitoes. The problem of parasite resistance towards common available medicines such as chloroquine, mefloquine, quinine, is increasing. In this context, the vegetal kingdom remains the main source of pharmacologically active compounds against this parasitic infection as attested by the famous quinine, isolated from Cinchona sp., artemisinin extracted from Artemisia annua and also atovaquone derived from lapachol found in several Bignoniaceae. All these substances are related to plants with traditional use against fever and malaria. Beside these well-known examples, various new antiplasmodial compounds are frequently discovered from Nature, particularly following an ethnopharmacological approach, as reviewed by several authors in recent years [2-6]. Then, the pharmacological and phytochemical study of plants from traditional pharmacopoeias can be of first interest not only to discover new antimalarial “lead compounds”, but also to valorize local vegetal species whose efficacy and safety would have been demonstrated in laboratory and by clinical investigations [7,8]. Some results obtained with Dicoma tomentosa from Burkina-Faso [9] and Terminalia mollis from Rwanda [10] will be presented. In the second part of the talk, two applications of biotechnology for the production of artemisinin and paclitaxel and then some works developed at the ‘Université de la Réunion’ will be presented. In the framework of this collaboration, Psiadia arguta, an endemic plant from Reunion Island, which is known to have cytotoxic, anti-plasmodial and anti-inflammatory properties, was subjected to micropropagation. The objective of the work was to compare the biological properties and the phytochemical composition of callus, vitroplants and acclimatized plants of Psiadia arguta [11]. 1. WHO, World Malaria Report 2014, December 2014, Geneva (http://www.who.int/malaria/publications/world_malaria_report_2014/en/). 2. Batista R, Silva Ade J Jr, de Oliveira AB: Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products. Molecules 2009, 14:3037-72. 3. Bero J, Frédérich M, Quetin-Leclercq J : Antimalarial compounds isolated from plants used in traditional medicine. Journal of Pharmacy and Pharmacology 2009, 61:1401–1433. 4. Bero J and Quetin-Leclercq J: Natural products published in 2009 from plants traditionally used to treat malaria. Planta Medica 2011, 77:631-40. 5. Kaur K, Jain M, Kaur T, Jain R: Antimalarials from nature. Bioorganic & Medicinal Chemistry 2009, 17:3229–3256. 6. Nogueira CR and Lopes LMX: Antiplasmodial Natural Products. Molecules 2011, 16:2146-2190 7. Ginsburg H and Deharo E: A call for using natural compounds in the development of new antimalarial treatments – an introduction. Malaria Journal 2011, 10 (suppl. 1):S1 8. Willcox M, Graz B, Falquet J, Diakite C, Giani S, Diallo D: A “reverse pharmacology” approach for developing an antimalarial phytomedicine. Malaria journal 2011, 10(suppl1):S8 9. Jansen, O., Tits, M., Angenot, L., Nicolas, J.-P., De Mol, P., Nikiema, J.-B., & Frédérich, M : Anti-plasmodial activity of Dicoma tomentosa (Asteraceae) and identification of urospermal A-15-O-acetate as the main active compound. Malaria Journal 2012, 11, 289. 10. Muganga, R., Angenot, L., Tits, M., & Frédérich, M : In vitro and in vivo antiplasmodial activity of three Rwandan medicinal plants and identification of their active compounds. Planta Medica 2013, 80(6), 482-489. 11. Mahy Justine, Comparative study of biological activities and analysis of volatile compounds of Psiadia arguta in various cultures: vitroplants and acclimatized plants. Mémoire de M2, 2013, Université de Liège/Université de la Réunion. [less ▲]

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See detailMyoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells.
Fahmy, Karim ULg

Poster (2015, September 24)

In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in ... [more ▼]

In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in pancreas cancer cells, BxPC-3, provoques a decrease in cell prolifération in vitro and a decrease in tumor volumes in animal model. Myoferlin silencing also provokes a decrease in VEGF-A secretion in the conditioned medium and that decrease was abserved in the animal model as a decrease in microvessels dencity. It appeared that this decrease in secretion is due to a a blockage in the exocytosis. Our data also showed a significate correlation between myoferlin expression and microvessels density in patients section. [less ▲]

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See detailVALIDATION RELEVANCE OF ANALYTICAL METHODS IN BIOTECHNOLOGY
Marini Djang'Eing'A, Roland ULg; Hubert, Philippe ULg

Conference (2015, September 24)

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See detailPerformances of a simple exhaust mechanical ventilation coupled to a mini heat pump: modeling and experimental investigations
Ransy, Frédéric ULg; Gendebien, Samuel ULg; Lemort, Vincent ULg

Conference (2015, September 24)

According to the European directive 2012/27/EU of October 2012 on energy efficiency, buildings represented 40 % of the EU’s final energy consumption in 2011. The major part of this energy consumption is ... [more ▼]

According to the European directive 2012/27/EU of October 2012 on energy efficiency, buildings represented 40 % of the EU’s final energy consumption in 2011. The major part of this energy consumption is due to the residential sector for space heating and domestic hot water production. Moreover, buildings are crucial to achieve the EU objective of reducing greenhouse gas emissions by 80-95 % by 2050 compared to 1990. In order to reduce these greenhouse gas emissions, retrofit measures regarding insulation and air-tightness have to be taken. However, such improvements of the building envelope lead to a relative increase in consumption related to ventilation. Indeed, according to Orme (2001), Roulet et al. (2001) and Fouih et al. (2012), the heating demand due to ventilation can reach more than 50 % of the total building heating demand for new and retrofitted buildings. To reduce the energy consumption due to ventilation, exhaust air heat pumps (EAHPs) can be used instead of the traditional heat recovery with an air-to-air heat exchanger. EAHPs recover heat from the exhaust air of the ventilation system to produce domestic hot water and space heating. According to Fehrm et al. (2002), this technology is already widely used in the northern countries such as Germany and Sweden. In fact, according to Fracastoro et al. (2010), efficiencies of EAHPs are higher than those obtained with outside air or geothermal heat pumps in certain conditions, whatever the climate location. Berg et al. (2010) have monitored three houses in Sweden equiped with exhaust air heat pumps. The seasonal performance factor (SPF) values were all within the range 1.4-1.7. This factor takes into account the energy consumption of the heat pumps and the auxiliary heating systems. A 17 kW exhaust air heat pump has also been tested by Mikola et al. (2014). The measured SPF for the heat pump only (without taking into account the auxiliary heating system) was about 2.9-3.4 in winter and 3 in the summer. Exhaust air heat pumps coupled with simple exhaust mechanical ventilation systems have many advantages compared to traditional balanced systems with heat recovery: • Only one fan is necessary and the duct system is simpler. Consequently, EAHPs are suitable for retrofitted buildings. • The heat pump can provide the whole part of the heating demand related to domestic hot water and 50 % of the heating demand related to space heating, according to Fracastoro et al. (2010). • The heat pump can also provide active cooling by inversing the refrigerating cycle. • The heat pump performance is high and remains constant with outdoor temperature changes since the temperature of the heat sink is constant (20°C). As a result, the system is cost-effective. • The system is compact, quiet and requires little maintenance. In the present paper, the energetic performances of an exhaust air heat pump are assessed through numerical and experimental studies. The thermal capacity of the machine is 1.5 kW when the inside air temperature is 20°C and the outside water temperature is 35°C. The heat pump is therefore ideally suited for new or retrofitted buildings. The system including a mechanical exhaust ventilation system and an exhaust air heat pump is first presented. Secondly, the heat pump model used afterwards to determine the heat pump seasonal performance factor is described. Thirdly, the model is calibrated to fit the measurement data. Finally, the heat pump model is coupled to a building model to determine the annual performance of the system. The system is compared to a traditional balanced ventilation system with heat recovery in terms of primary energy consumption, for different heating and DHW production systems (electric heater, heat pump, gas condensing boiler). [less ▲]

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See detailPerformances analytiques d’un biomarqueur : dialogue
CAVALIER, Etienne ULg

Conference (2015, September 23)

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See detailUse of the wavelet theory as a tool to investigate the l-abelian complexity of a sequence
Kleyntssens, Thomas ULg; Nicolay, Samuel ULg; Vandomme, Elise ULg et al

Poster (2015, September 23)

The concept of k-automatic sequences is at the intersection of number theory and formal language theory. It has been generalized by the notion of k-regularity that allows to study sequences with values in ... [more ▼]

The concept of k-automatic sequences is at the intersection of number theory and formal language theory. It has been generalized by the notion of k-regularity that allows to study sequences with values in a (possibly infinite) ring. This concept provides us with structural information about how the different terms of the sequence are related to each other. They are many different notions related to the measure of complexity of an infinite sequence w. A classical approach is its factor complexity. In an abelian context, the analogue to the factor complexity is the abelian complexity where the number of distinct factors of length n is counted up to abelian equivalence. The notion of abelian complexity was extended to that of l-abelian complexity. In this talk, I propose to use tools from the wavelet theory to analyze the l-abelian complexity. For the numerical simulations, I apply the wavelet leaders method that allows to study the pointwise regularity of signals. [less ▲]

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See detailStratospheric HCl increasing again, caused by dynamic variability, driven by increased tropopsheric wave activity
Notholt, J; Mahieu, Emmanuel ULg; Pfloeger, F et al

Conference (2015, September 22)

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See detailThe Shadow Positioning Sensors (SPS) for formation flying metrology on-board the ESA-PROBA3 mission
Bemporad, A.; Baccani, C.; Capobianco, G. et al

in Proc. SPIE Volume 9604 Solar Physics and Space Weather Instrumentation VI (2015, September 21)

PROBA3 is an ESA technology mission devoted to in-orbit demonstration of the formation flight (FF) technique, with two satellites kept at an average inter-distance by about 144 m. The ASPIICS instrument ... [more ▼]

PROBA3 is an ESA technology mission devoted to in-orbit demonstration of the formation flight (FF) technique, with two satellites kept at an average inter-distance by about 144 m. The ASPIICS instrument on-board PROBA3 will be the first ever space-based coronagraph working on one satellite and having the external occulter located on the second satellite, thus allowing observations of the inner solar corona with unprecedented reduction of stray light. During the observational periods, the FF configuration will be maintained with very high precision and two different techniques will be implemented: the use of Shadow Positioning Sensors (SPS) located on the Coronagraph Spacecraft (diodes measuring the penumbral light intensity on the entrance pupil plane) and the use of Occulter Position Sensor LEDs (OPSE) located on the back side of the Occulter Spacecraft. This paper will review the main instrumental requirements on the SPS needed to determine the 3-dimensional relative positioning of the two PROBA3 satellites with the high precision and frequency. [less ▲]

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See detailSignificance of the occulter diffraction for the PROBA3/ASPIICS formation flight metrology
Landini, F.; Bemporad, A.; Focardi, M. et al

in Proc. SPIE Volume 9604 Solar Physics and Space Weather Instrumentation VI (2015, September 21)

PROBA-3/ASPIICS is a formation Flying coronagraph selected by ESA and currently in its C/D phase. It is constituted by two spacecrafts (OSC, Occulter SpaceCraft, carrying the occulter, diameter 142 cm ... [more ▼]

PROBA-3/ASPIICS is a formation Flying coronagraph selected by ESA and currently in its C/D phase. It is constituted by two spacecrafts (OSC, Occulter SpaceCraft, carrying the occulter, diameter 142 cm, and CSC, Coronagraph SpaceCraft, with the telescope) separated by ~144 m, kept in strict alignment by means of an active custom system. The alignment active system most critical components are the Shadow Positioning Sensors (SPS), a series of Si-PM (Silicon Photomultiplier) measuring the penumbra generated by the occulter. The arrangement of the SPSs around the telescope entrance aperture is defined as a trade-off between mechanical constraints and maximum sensitivity to misalignments. The signal detected by the SPSs can be approximately simulated with a geometrical analysis based on the variation of the penumbra generated by the external occulter. The stray light generated by the diffraction from the external occulter may affect the SPSs signal. It is mandatory to carefully evaluate its level in order to refine the active alignment adjustment algorithm. This work is dedicated to the description of the preliminary investigation performed in order to evaluate the impact of the diffraction on the SPSs signal. [less ▲]

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See detailAir-sea ice gases exchange: update of recent findings, outcomes from sea ice models, caveats and open questions
Delille, Bruno ULg; Zhou, Jiayun; Kotovitch, Marie ULg et al

Conference (2015, September 21)

There are growing evidences that sea ice exchanges climate gases with the atmosphere. We will rapidly present a state of the art of current large scale assessment of spring and summer uptake of ... [more ▼]

There are growing evidences that sea ice exchanges climate gases with the atmosphere. We will rapidly present a state of the art of current large scale assessment of spring and summer uptake of atmospheric CO2. We will challenge these assessments with 1) new evidence of significant winter CO2 release for winter experiments 2) new finding of the role of bubbles formation and transport within sea ice and 3) impurities expulsion derived from combined artificial ice experiment and modelling. Finally, comparison of air-ice fluxes derived from automated chamber and micrometeorological method and, mechanistic and box models show significant discrepancies that suggest that the contribution of sea ice to the air-ocean fluxes of CO2 remain an open question. We will also highlight that sea ice contribute to the fluxes of other gases as CH4 ,N2O and DMS [less ▲]

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See detailOPSE metrology system onboard of the PROBA3 mission of ESA
Loreggia, D.; Bemporad, A.; Capobianco, G. et al

in Proc. SPIE Volume 9604 Solar Physics and Space Weather Instrumentation VI (2015, September 21)

In recent years, ESA has assessed several mission involving formation flying (FF). The great interest in this topics is mainly driven by the need for moving from ground to space the location of next ... [more ▼]

In recent years, ESA has assessed several mission involving formation flying (FF). The great interest in this topics is mainly driven by the need for moving from ground to space the location of next generation astronomical telescopes overcoming most of the critical problems, as example the construction of huge baselines for interferometry. In this scenario, metrology systems play a critical role. PROBA3 is an ESA technology mission devoted to in-orbit demonstration of the FF technique, with two satellites, an occulter and a main satellite housing a coronagraph named ASPIICS, kept at an average inter-distance by about 144m, with micron scale accuracy. The guiding proposal is to test several metrology solution for spacecraft alignment, with the important scientific return of having observation of Corona at never reached before angular field. The Shadow Position Sensors (SPS), and the Optical Position Emitters Sensors (OPSE) are two of the systems used for FF fine tracking. The SPS are finalized to monitor the position of the two spacecraft with respect to the Sun and are discussed in dedicated papers presented in this conference. The OPSE will monitor the relative position of the two satellites and consists of 3 emitters positioned on the rear surface of the occulter, that will be observed by the coronagraph itself. By following the evolution of the emitters images at the focal plane the alignment of the two spacecrafts is retrieved via dedicated centroiding algoritm. We present an overview of the OPSE system and of the centroiding approach. [less ▲]

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See detailDesign and modelisation of ASPIICS optics
Galy, Camille ULg; Fineschi, S.; Galano, D. et al

in Proc. SPIE Volume 9604 Solar Physics and Space Weather Instrumentation VI (2015, September 21)

In the framework of development of ASPIICS (Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun), the Centre Spatial de Liege is responsible of the optical design ... [more ▼]

In the framework of development of ASPIICS (Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun), the Centre Spatial de Liege is responsible of the optical design of the coronagraph and the optics will be manufactured by TOPTEC. The particularity of this coronagraph is to have an external occulter located 150 m ahead of the first imaging lens. This external occulter is re-imaged on an internal occulter which function is - as in a classical externally occulted Lyot coronagraph - to block the sun light diffracted by the external occulter and to reduce the straylight on the detector. The selection of this configuration is driven by the requirement to observe the corona as close as possible to the solar limb (i.e. 1 RSun) without imaging the limb itself. A requirement of 1.08 RSun is specified at optical design level to grant 1.2 Rsun at instrument level. The coronograph instrument is designed to have a field of view of 1.6° x 1.6° with a resolution of less than 6 arcsec. Its performances are limited by diffraction in a 530 – 590 nm wavelength range. This paper presents the optical design and demonstrates that by design the requirements are fulfilled within the misalignment, manufacturing and thermo-elastic error contributions. [less ▲]

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See detailDesign status of ASPIICS, an externally occulted coronagraph for PROBA-3
Renotte, Etienne ULg; Alia, A.; Bemporad, A. et al

in Proc. SPIE Volume 9604 Solar Physics and Space Weather Instrumentation VI (2015, September 21)

The “sonic region” of the Sun corona remains extremely difficult to observe with spatial resolution and sensitivity sufficient to understand the fine scale phenomena that govern the quiescent solar corona ... [more ▼]

The “sonic region” of the Sun corona remains extremely difficult to observe with spatial resolution and sensitivity sufficient to understand the fine scale phenomena that govern the quiescent solar corona, as well as phenomena that lead to coronal mass ejections (CMEs), which influence space weather. Improvement on this front requires eclipse-like conditions over long observation times. The space-borne coronagraphs flown so far provided a continuous coverage of the external parts of the corona but their over-occulting system did not permit to analyse the part of the white-light corona where the main coronal mass is concentrated. The proposed PROBA-3 Coronagraph System, also known as ASPIICS (Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun), with its novel design, will be the first space coronagraph to cover the range of radial distances between ~1.15 and 3 solar radii where the magnetic field plays a crucial role in the coronal dynamics, thus providing continuous observational conditions very close to those during a total solar eclipse. PROBA-3 is first a mission devoted to the in-orbit demonstration of precise formation flying techniques and technologies for future European missions, which will fly ASPIICS as primary payload. The instrument is distributed over two satellites flying in formation (approx. 150m apart) to form a giant coronagraph capable of producing a nearly perfect eclipse allowing observing the sun corona closer to the rim than ever before. The coronagraph instrument is developed by a large European consortium including about 20 partners from 7 countries under the auspices of the European Space Agency. This paper is reviewing the recent improvements and design updates of the ASPIICS instrument as it is stepping into the detailed design phase. [less ▲]

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See detailFormation flying metrology for the ESA-PROBA3 mission: the Shadow Position Sensors (SPS) silicon photomultipliers (SiPMs) readout electronics
Focardi, M.; Bemporad, A.; Buckley, S. et al

in Proc. SPIE Volume 9604 Solar Physics and Space Weather Instrumentation VI (2015, September 21)

The European Space Agency (ESA) is planning to launch in 2018 the PROBA3 Mission, designed to demonstrate the inorbit formation flying (FF) attitude capability of its two satellites and to observe the ... [more ▼]

The European Space Agency (ESA) is planning to launch in 2018 the PROBA3 Mission, designed to demonstrate the inorbit formation flying (FF) attitude capability of its two satellites and to observe the inner part of the visible solar corona as the main scientific objective. The solar corona will be observed thanks to the presence on the first satellite, facing the Sun, of an external occulter producing an artificial eclipse of the Sun disk. The second satellite will carry on the coronagraph telescope and the digital camera system in order to perform imaging of the inner part of the corona in visible polarized light, from 1.08 Rsun up to about 3 Rsun. One of the main metrological subsystems used to control and to maintain the relative (i.e. between the two satellites) and absolute (i.e. with respect to the Sun) FF attitude is the Shadow Position Sensor (SPS) assembly. It is composed of eight micro arrays of silicon photomultipliers (SiPMs) able to measure with the required sensitivity and dynamic range the penumbral light intensity on the Coronagraph entrance pupil. In the following of the present paper we describe the overall SPS subsystem and its readout electronics with respect to the capability to satisfy the mission requirements, from the light conversion process on board the silicon-based SPS devices up to the digital signal readout and sampling. [less ▲]

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See detailPathways of recurrent high-grade squamous intraepithelial lesions of the cervix
Herfs, Michael ULg

Conference (2015, September 20)

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Peer Reviewed
See detailNon-invasive markers: the role of G-CSF?
Munaut, Carine ULg

Conference (2015, September 19)

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See detailSoluble biomarkers in OA: can they be used as indicator of HA re-injection?
Henrotin, Yves ULg

Conference (2015, September 18)

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Peer Reviewed
See detailDietary mineral intakes of young Tibetan children living in areas endemic for Kashin-Beck disease: preliminary results of a cross-sectional survey
DERMIENCE, Michael ULg; Mathieu, Françoise; Li, Xiaowei et al

Conference (2015, September 18)

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy whose etiology remains unclear. Environmental factors are assumed to be involved, among which the selenium and iodine deficiency is ... [more ▼]

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy whose etiology remains unclear. Environmental factors are assumed to be involved, among which the selenium and iodine deficiency is frequently cited. The prevalence rate may be high in some rural areas of the Tibet Autonomous Region. The diet of the rural community is significantly different from the other communities (nomads and city-dwellers), who remains unaffected by KBD. Because their foods are mainly derived from local agriculture and artisanal production, their mineral composition may show significant discrepancies when compared with food composition data. The present survey aims at assessing the mineral dietary intakes of young Tibetan children living in rural areas endemic for the Kashin-Beck disease. A cross-sectional survey enrolling 250 children was carried out. The intakes were recorded for two days, on two different seasons, by the 24-hour food recall method. The minerals investigated were selected for their implication in bone metabolism and a specific food composition table was compiled from the China Food composition (book 1, 2nd edition), the USDA Food search for Windows (Version 1.0, Database version SR23), and a broad investigation on mineral composition of local and traditional Tibetan foods (Dermience et al., 2014). The calculation of daily intakes for the first season is now complete and some trends are emerging. Preliminary results suggest, inter alia, that the intakes of calcium are too low with unfavorable calcium to phosphorus ratio. On the contrary, sodium and manganese intakes are too high and could exceed tolerable upper levels. [less ▲]

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See detailThe importance of physical educators’ representations about physical activity
Cloes, Marc ULg

Conference (2015, September 18)

Physical education (PE) teachers need to develop clear representaitons about physical activity (PA). In fact, they have to promote an active lifestyle among their pupils/students and it will not be ... [more ▼]

Physical education (PE) teachers need to develop clear representaitons about physical activity (PA). In fact, they have to promote an active lifestyle among their pupils/students and it will not be possible without developing an extended knowledge about physical activity. This presentation has been designed in order to make the PE teachers and their trainers that their representations about PA could be worse than they believe. Moreover, the interactive way of this presentation will provide an interesting example of an approach that could be used on the field. [less ▲]

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See detailNid de coucou. De quelques performances filmées dans l'espace public.
Hamers, Jérémy ULg

Conference (2015, September 18)

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See detailEFFECT OF TRUNK MOTOR CONTROL TRAINING IN ELITE SOCCER PLAYERS WITH LOW BACK PAIN
GROSDENT, Stéphanie ULg; Demoulin, Christophe ULg; Rodriguez de la Cruz, Carlos ULg et al

Poster (2015, September 18)

Background and aims: The purpose of this study was to examine the effect of a motor control training program on the lumbopelvic motor control (LMC) in elite soccer players with a history of low back pain ... [more ▼]

Background and aims: The purpose of this study was to examine the effect of a motor control training program on the lumbopelvic motor control (LMC) in elite soccer players with a history of low back pain (LBP). Methods: Twenty-four male elite soccer players (mean age of 18.3 years) filled in questionnaires related to LBP and were divided into two groups: 12 players with a history of LBP (LBP group) and 12 players without a history of LBP (no LBP group). Then, they performed five LMC tests [the Bent Knee Fall Out test (BKFO), the Knee Lift Abdominal Test (KLAT), the Sitting Knee Extension Test (SKET), the Waiter’s Bow (WB) and the test of the transversus abdominis (TrA)] which were conducted and scored (0=failed, 1=correct) by a physiotherapist, blinded to the medical history of the participants. The total LMC score (ranging from 0 to 5) was calculated by adding the score at each test. During the following 10 weeks, the no LBP group conducted a soccer training as usual while LBP group performed an additional specific core stability program (1h/week). Results: At baseline, the participants of the LBP group had a worse LMC than the no LBP group (mean LMC score of 1.1 vs 3.1, p<0.01). The between-groups difference was particularly marked for the BKFO (p<0.01), KLAT (p<0.01) and SKET (p<0.05) tests. At the end of the intervention program, the LMC score of the players with a history of LBP increased significantly (p<0.0001) and was similar to the score of the players without a history of LBP (mean LMC score of 3.2 vs 3.3, p=1.00). Conclusions: LMC can be decreased in elite active soccer players with a history of LBP. Specific core stability program is effective to improve LMC in these players. [less ▲]

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See detailInnovation in Veterinary Education. Innovative tools to teach pregnancy and parturition in the horse.
Hanzen, Christian ULg; Govaere, Jan

Conference (2015, September 18)

Detailed reference viewed: 81 (3 ULg)
See detailworkshop:laryngoscopy hands on station
Finck, Camille ULg

Conference (2015, September 17)

training of a group of 20 endocrine surgeons to correctly perform a laryngeal examination in fibroscopy. Live examination of a patient suffering of laryngeal paralysis

Detailed reference viewed: 7 (0 ULg)
See detailPriniples of Voice production
Finck, Camille ULg

Conference (2015, September 17)

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See detailUnderground Pumped Storage Hydroelectricity (UPSH) using abandoned works
Pujades, Estanislao ULg; Willems, Thibault ULg; Orban, Philippe ULg et al

Poster (2015, September 17)

Underground Pumped Storage Hydroelectricity (UPSH) using abandoned works is an interesting alternative to increase the efficiency of some power plants, which cannot regulate the amount of electricity ... [more ▼]

Underground Pumped Storage Hydroelectricity (UPSH) using abandoned works is an interesting alternative to increase the efficiency of some power plants, which cannot regulate the amount of electricity generated according to the demand. UPSH plants can store (pumping water from an underground to an upper reservoir) or produce energy (releasing water from an upper to an underground reservoir) during the low or high demand periods. Two considerations must be taken into account in order to construct an UPSH plant: 1) the alteration of the natural conditions of aquifers and 2), the efficiency of the plant, which depends on the hydraulic head inside the underground reservoir. Obviously, a detailed numerical model must be necessary to design a plant. However, a screening methodology to apply during the early stages of the design of a UPSH plant in order to reject the most disadvantageous sites in a short period of time would be useful. Groundwater flow impacts caused by UPSH plants are analyzed numerically and the main variables involved in the groundwater evolution are identified. The most noticeable effect consists in an oscillation of the groundwater. The hydraulic head around which groundwater oscillates, the magnitude of the oscillations and the time to achieve a pseudo-steady state (magnitude and head reached during oscillations do not vary anymore with time) depend on the boundaries, the parameters of the aquifer and the characteristics of the underground reservoir. From the numerical study, a screening methodology, which is based on existing analytical procedures (solutions for large diameter wells, methodologies for cyclic pumpings and the image well theory), is proposed to assess the main impacts caused in aquifers by UPSH plants and their efficiency regarding the groundwater evolution inside the reservoir. The procedure can be applied in a relatively short period of time and is useful to select those appropriate sites to construct a UPSH plant. [less ▲]

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See detailHydrogeological assessment of diaphragm walls used to excavate deep shafts associated to tunnels construction
Pujades, Estanislao ULg; Jurado, Anna; Carrera, Jesus et al

Poster (2015, September 17)

Deep shafts are usually required during tunnels construction (for maintenance tasks when tunnel boring machines –TBM- are used) and/or the operation stage of tunnels (emergency exits). Generally, these ... [more ▼]

Deep shafts are usually required during tunnels construction (for maintenance tasks when tunnel boring machines –TBM- are used) and/or the operation stage of tunnels (emergency exits). Generally, these shafts are constructed below the water table and by the cut and cover method. Therefore, impervious diaphragm walls are desired for two main reasons: (1) to reduce risks (stability, inflows, flooding, etc.) and outside impacts (loose of groundwater resource, holes and sinkholes, etc.) during the excavation stage of a shaft and, (2) to avoid leaks and inflows of groundwater during the operation stage once the shaft is finished. Given that defects in diaphragm walls are frequent and can relatively easy be repaired before starting the excavation stage, a useful and new methodology to assess the state of enclosures before excavation is proposed. Its use would allow to reduce impacts on groundwater (construction and operation stages) and costs in case of defects as well as to increase the safety during the construction. The groundwater response regarding different scenarios of diaphragm walls is studied numerically in order to propose a successful procedure to evaluate underground enclosures imperviousness by internal pumping tests. The scenarios consist in circular and square enclosures where the diaphragm walls are assumed as homogeneous (with numerous defects) or heterogeneous (one discrete defect). The homogeneous cases are modeled by considering different effective hydraulic conductivities, while the size and position of the single defect is varied in the simulations of heterogeneous walls. An analysis of diagnostic plots and the comparison between the expected and measured groundwater evolutions inside the enclosure, is proposed to ascertain: (1) if the diaphragm walls can be considered as homogeneous or heterogeneous, (2) the effective hydraulic conductivity of the walls (if they are homogeneous) and, (3) the position of a defect (if they are heterogeneous). [less ▲]

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See detailAnalytical performance of a biomarker: what the clinician should know
CAVALIER, Etienne ULg

Conference (2015, September 17)

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See detailBien soigner l'arthrose: un enjeu capital pour notre société!
Henrotin, Yves ULg

Conference (2015, September 17)

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See detailStability and Aging of Phase Change Materials : An Ab Initio Perspective
Raty, Jean-Yves ULg

Conference (2015, September 17)

Data recording with Phase Change Materials is a much studied topic as the writing/erasing characteristics, cyclability and downscaling properties of these materials allow for efficient data storage in ... [more ▼]

Data recording with Phase Change Materials is a much studied topic as the writing/erasing characteristics, cyclability and downscaling properties of these materials allow for efficient data storage in future generations of devices. Nevertheless, some aspects of phase change materials are limiting their performances and delaying their wider technological application. First, aging phenomena are common to all amorphous structures, but of special importance PCMs since it impedes the realization of multi-level memories. Different interpretations have been proposed, but we focus here on the structural relaxation of amorphous GeTe, chosen because it is the simplest system that is representative of the wider class of GST alloys, lying along the GeTe-Sb2Te3 composition line of the GeSbTe phase diagram. One difficulty encountered in the simulation of these amorphous systems is that the direct generation of an amorphous structure by quenching a liquid using Density Functional Theory (DFT) based Molecular Dynamics leads to one sample with a small number of atoms, and, hence of small number of atomic environments. Here we sample a large number of local atomic environments, corresponding to different bonding schemes, by chemically substituting different alloys, selected to favor different local atomic structures. This enables spanning a larger fraction of the configuration space relevant to aging. Our results support a model of the amorphous phase and its time evolution that involves an evolution of the local (chemical) order towards that of the crystal. On the other hand its electronic properties drift away from those of the crystal, driven by an increase of the Peierls-like distortion of the local environments in the amorphous, as compared to the crystal [1]. A second problem faced by PCMs is the fact that data recording is limited at high temperature due to the increased propensity to recrystallize. One approach to counter this is to stabilize the PCM using impurity atoms such as C or N. Using DFT and the analysis of the mechanical properties (constraints theory), we demonstrate how these impurity atoms modify the rigidity of the network, which is experimentally correlated with the activation energy for crystallization [2]. Finally, the crystal phase itself has been shown to have variable conductivities depending on the thermal history and annealing conditions. If this could be used profitably for multi-level recording, it also indicates that the crystal is undergoes some temporal evolution. Using DFT, we clarify the stability behavior of GST crystal and show that the metal-insulator transition is driven by the migration of intrinsic vacancies and an Anderson localization transition [3]. [1] J.Y Raty, W. Zhang, J. Luckas, C. Chen, R. Mazzarello, C. Bichara and M. Wuttig, Nat. Comm. (2015) [2] G. Ghezzi, J.Y. Raty, S. Maitrejean, A. Roule, E. Elkaim and F. Hippert, Applied Physics Letters, 99 (2011) 151906 [3] W. Zhang, A. Thiess, P. Zalden, R. Zeller, P. H. Dederichs, J-Y. Raty, M.Wuttig, S. Blügel et R. Mazzarello, Nature Materials 11 (2012) 952 [less ▲]

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See detailThe system of sanctions for the illicit trade of nuclear goods
Colussi, Ilaria Anna ULg

Conference (2015, September 17)

In the area of nuclear non proliferation, the illicit trade of goods that could be used to create nuclear weapons cannot be neglected. Indeed, many States and non-States actors seeking nuclear weapons or ... [more ▼]

In the area of nuclear non proliferation, the illicit trade of goods that could be used to create nuclear weapons cannot be neglected. Indeed, many States and non-States actors seeking nuclear weapons or wanting to maintain existing nuclear weapons arsenals or capabilities look for obtaining, acquiring and transporting in their own States or locations dual-use technologies, items and materials. This entails a chain of “actors”: (a) the suppliers of goods, (b) a procurement organization, (c) a trade company for the procurement of goods, (d) intermediaries in transport, and (e) banks which could finance the operations. Therefore, a set of measures for preventing the illicit trade, and for sanctioning the occurred one, need to be defined. The paper aims at focusing on the “sanctioning” phase for illicit trade of dual-use nuclear items. It analyses the set of sanctions established at the international and European Union level, precisely the economic sanctions (e.g.: embargos), the financial one (i.e., freezing of assets), the visa and travel bans, and the limitations on transport of goods (i.e., export/import restrictions), by considering the legal texts adopted in the international and European Union framework, according to a comparative analysis. [less ▲]

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See detailUse of dual carbon-chlorine isotope analysis to identify degradation pathways of 1,1,1-trichloroethane in groundwater
Palau, Jordi; Jamin, Pierre ULg; Badin, Alice et al

Conference (2015, September 17)

The high susceptibility of chlorinated aliphatic hydrocarbons (CAHs) like 1,1,1-trichloroethane (1,1,1-TCA) to be transformed via different competing pathways (biotic and abiotic) complicates the ... [more ▼]

The high susceptibility of chlorinated aliphatic hydrocarbons (CAHs) like 1,1,1-trichloroethane (1,1,1-TCA) to be transformed via different competing pathways (biotic and abiotic) complicates the assessment of their fate in groundwater. This knowledge is necessary to evaluate contaminant degradation and potential formation of toxic intermediates. Identifying pathways is further complicated in sites contaminated by mixed CAHs because some degradation products of 1,1,1-TCA can be formed from different precursors. Here, identification of pathways based solely on substrate-product concentration relationships may lead to ambiguous interpretations. This study investigates, for the first time, dual C−Cl isotope fractionation as a means of identifying and assessing degradation pathways of 1,1,1-TCA in groundwater. Distinctly different dual isotope trends (L = Δδ13C/Δδ37Cl) were observed for 1,1,1-TCA transformation via oxidation with heat-activated persulfate (L = ∞), reduction with zerovalent iron (L = 1.5 ± 0.1), hydrolysis and dehydrohalogenation (HY/DH, L = 0.33 ± 0.04) in laboratory experiments, illustrating the potential of a dual isotope approach. This approach was evaluated in an aerobic aquifer impacted by 1,1,1-TCA and trichloroethylene (TCE) with concentrations of up to 20 mg/L and 3.4 mg/L, respectively. For 1,1,1-TCA, the dual isotope slope determined from field samples (L = 0.6 ± 0.2, r2 = 0.75) was close to the slope observed for HY/DH in the laboratory (L = 0.33 ± 0.04), indicating that HY/DH was the predominant degradation pathway of 1,1,1-TCA in the aquifer. The observed deviation could be explained by a minor contribution of additional degradation processes. This result, along with the little degradation of TCE determined from isotope measurements, confirmed that 1,1,1-TCA was the main source of the 1,1-dichlorethylene (1,1-DCE) detected in the aquifer with concentrations of up to 10 mg/L. This study demonstrates that a dual C-Cl isotope approach can strongly improve the qualitative and quantitative assessment of 1,1,1-TCA degradation processes in the field. [less ▲]

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See detailSurgir dans le paysage urbain. Analyse sociocritique du projet Selfiecity
Hagelstein, Maud ULg

Conference (2015, September 17)

Mon intérêt pour le selfie s’inscrit dans le cadre d’une réflexion plus large sur la photographie vernaculaire (ou commune – au double sens du terme), c’est-à-dire celle qui n’est ni professionnelle, ni ... [more ▼]

Mon intérêt pour le selfie s’inscrit dans le cadre d’une réflexion plus large sur la photographie vernaculaire (ou commune – au double sens du terme), c’est-à-dire celle qui n’est ni professionnelle, ni explicitement artistique. Le selfie est un outil visuel qui me semble pouvoir bien fonctionner avec la thématique de l’espace urbain : *le selfie travaille à la mise en scène d’un sujet dans un contexte au sein duquel il s’implique, le sujet ayant ceci de particulier qu’il se constitue à la fois comme observateur d’une scène, opérateur de l’image (= opérateur de la représentation de cette scène) et comme figurant de celle-ci (partie de son contenu). *En tant qu’il indique donc bien souvent une interaction entre un sujet et son environnement (spatial, social), le selfie pourrait être un bon indicateur du rapport de figuration, d’intégration, liant l’homme à son espace urbain (direct ou indirect). Il m’intéressera ici pour une seconde raison (dont les enjeux sont plus directement politiques) : puisque le dispositif est relativement nouveau, en développement, le selfie peut servir en quelque sorte de laboratoire dans lequel on pourrait observer la constitution de normes formelles. Autrement dit, la nouveauté de cette forme d’expression lui permet d’échapper relativement (et sans doute provisoirement) à l’inévitable institutionnalisation progressive que connaît généralement l’art urbain. [less ▲]

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See detailGeophysics for the quantification of water fluxes in the soil-plant system
Garré, Sarah ULg; Binley, Andrew

Conference (2015, September 17)

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Peer Reviewed
See detailNDS27, the soluble derivative from curcumin binds to and inhibits myeloperoxidase
Franck, Thierry ULg; Derochette, Sandrine ULg; Zouaoui-Boudjeltia, Karim et al

Poster (2015, September 16)

Detailed reference viewed: 10 (1 ULg)
Peer Reviewed
See detailVocabulaire liturgique et strates lexicales en indo-iranien ancien
Swennen, Philippe ULg

Conference (2015, September 16)

Detailed reference viewed: 14 (0 ULg)
See detailBuilding bridges (preliminary steps towards a new dictionary of Ancient Egyptian)
Winand, Jean ULg

Conference (2015, September 16)

Detailed reference viewed: 26 (1 ULg)
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See detailExoplanet science with the LBTI: instrument status and plans
Defrère, D.; Hinz, P.; Skemer, A. et al

in Shaklan, Stuart (Ed.) Techniques and Instrumentation for Detection of Exoplanets VII (2015, September 16)

The Large Binocular Telescope Interferometer (LBTI) is a strategic instrument of the LBT designed for high-sensitivity, high-contrast, and high-resolution infrared (1.5-13 $\mu$m) imaging of nearby ... [more ▼]

The Large Binocular Telescope Interferometer (LBTI) is a strategic instrument of the LBT designed for high-sensitivity, high-contrast, and high-resolution infrared (1.5-13 $\mu$m) imaging of nearby planetary systems. To carry out a wide range of high-spatial resolution observations, it can combine the two AO-corrected 8.4-m apertures of the LBT in various ways including direct (non-interferometric) imaging, coronagraphy (APP and AGPM), Fizeau imaging, non-redundant aperture masking, and nulling interferometry. It also has broadband, narrowband, and spectrally dispersed capabilities. In this paper, we review the performance of these modes in terms of exoplanet science capabilities and describe recent instrumental milestones such as first-light Fizeau images (with the angular resolution of an equivalent 22.8-m telescope) and deep interferometric nulling observations. [less ▲]

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See detailAnnotations as reflection amplifiers in online learning - An exploratory study
Verpoorten, Dominique ULg; Specht, Marcus; Westera, Wim

in Ullmann, T; Kravcik, M; Mikroyannidis, A (Eds.) et al Proceedings of the 5th Workshop on Awareness and Reflection in Technology-Enhanced Learning (ARTEL). In conjunction with the 10th european conference on technology enhanced learning: Design for teaching and learning in a networked world. (2015, September 15)

In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course at 3 conditions: no/free/question-based electronic annotations. Results show no ... [more ▼]

In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course at 3 conditions: no/free/question-based electronic annotations. Results show no difference in performance between groups. However, analyses conducted within treatments suggest positive impacts on performance when annotation rates are taken into consideration, and coupled with other reflective enactments. [less ▲]

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See detailEmpirical comparison of scoring rules at early stages of CAT
Magis, David ULg

Conference (2015, September 15)

Usual scoring rules in CATs include maximum likelihood (ML), weighted likelihood (WL) and Bayesian approaches. However, at early stages of adaptive testing, only a few item responses are available so the ... [more ▼]

Usual scoring rules in CATs include maximum likelihood (ML), weighted likelihood (WL) and Bayesian approaches. However, at early stages of adaptive testing, only a few item responses are available so the amount of information is very limited and in addition constant patterns (i.e. only correct or only incorrect responses) are often observed, yielding ML scoring intractable. Specific scoring rules (such as fixed- or variable stepsize adjustments) were developed for that purpose. However recent research highlighted that both Bayesian and WL scoring rules may provide finite values even with small sets of items. The purpose of this presentation is twofold: (a) to make a quick review of available scoring rules at early stages of CAT, and (b) to present empirical results from a simulation study that compares those scoring rules. More precisely, three scoring scenarios will be investigated: stepsize adjustment followed by ML, Bayes or WL followed by ML, and constant scoring rule throughout the CAT. These methods will be compared by means of simulated item banks and under various CAT scenarios for next item selection and stopping rules. Empirical results will be presented and practical guidelines for early stage scoring will be outlined. [less ▲]

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See detailLearning to look - Purpose and design of an awareness-raising online course in veterinary sciences
Tasnier, Sophie ULg; Busoni, Valeria ULg; Hanzen, Christian ULg et al

in Prilla, M; Ullmann, T; Kravcik, M (Eds.) et al Proceedings of the 5th Workshop on Awareness and Reflection in Technology-Enhanced Learning (2015, September 15)

This paper reports on a work in progress: an online self-instruction course created to stimulate students’ awareness processes when dealing with pictures. Using non-clinical material, the “Learning to ... [more ▼]

This paper reports on a work in progress: an online self-instruction course created to stimulate students’ awareness processes when dealing with pictures. Using non-clinical material, the “Learning to Look” course was de-signed as a preliminary training to the observation of histological sections, radi-ological graphs, and other specialized visual material. Following a presentation of the project, salient results of a feedback questionnaire completed by 382 stu-dents about their experience of the course are provided. [less ▲]

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See detailTowards processes-based groundwater vulnerability assessments
Dassargues, Alain ULg; Popescu, Cristina; Brouyère, Serge ULg

Conference (2015, September 15)

Various groundwater vulnerability methods have recently been developed. Considering groundwater quality issues, the most common techniques are based on calculation of an index expressing the protective ... [more ▼]

Various groundwater vulnerability methods have recently been developed. Considering groundwater quality issues, the most common techniques are based on calculation of an index expressing the protective effect (i.e. in terms of solute contaminant transport) of underground formations overlying the groundwater resource (Gogu & Dassargues, 2000, Gogu et al., 2003)). However, there is a strong need for new methods giving more emphasis on the processes-based calculation of vulnerability indicators. As a first alternative, a method is proposed based on three factors describing a pollution event (Brouyère et al., 2001): (1) the transit time from the source to the target, (2) the duration of the contamination breakthrough at the target, (3) the ratio between the maximum concentration at the target to the released concentration at the contamination source. The method can feature the impact of surface runoff to preferential infiltration points. Practically, the assessment can then be based on the simulated breakthrough curves at the ‘target’ corresponding to Dirac-type solicitations (Popescu et al., 2008). Different vulnerability maps can be built according to the relative importance conventionally given to each of the three factors. This concept allows a clear distinction between conventional aspects and processes-based results in the building of a final vulnerability indicator. A second proposal consists in reframing the groundwater vulnerability assessment in a Pressure-State-Impact causal chain that is familiar to decision makers (Beaujean et al., 2013). The method is here based on the calculation of sensitivity coefficients for a user-defined groundwater state for which several physically-based indicators are proposed. The sensitivity coefficients reflect the easiness with which the groundwater state transmits pressures into impacts. They are converted to vulnerability, using the concept of ‘transgressing a given threshold’ (Luers et al., 2003). While the methodology is general and can be applied in quantity as quality issues, the choice of causal chains has to be made prior to the calculation. The vulnerability is also related to a damaged state and is related to the ‘distance’ between the current state and a given threshold. Here also, the method allows a clear distinction between conventional choices (threshold) and scientific work (Dassargues et al., 2009). [less ▲]

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See detailQuestions à Nancy Fraser : Production et Reproduction du capital
Ghanbari Matin, Soheil ULg

Conference (2015, September 15)

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See detailThe Red Marble of Baelen, an exceptional mid-Famennian mud mound complex in a carbonate ramp setting from Eastern Belgium
Dreesen, Roland; Vachard, Daniel; Marion, Jean-Marc ULg et al

Poster (2015, September 14)

The Red Marble of Baelen from the Limbourg area (Vesdre Basin, Eastern Belgium) represents a member of the middle Famennian (late Upper Devonian) Souverain-Pré Formation (Late marginifera conodont Zone ... [more ▼]

The Red Marble of Baelen from the Limbourg area (Vesdre Basin, Eastern Belgium) represents a member of the middle Famennian (late Upper Devonian) Souverain-Pré Formation (Late marginifera conodont Zone). It corresponds to a short-term transgressive event and eustatic rise during the Famennian, interrupting the regressive megasequence on the Condroz shelf in Belgium. It is the only known or at least the only well-documented mid-Famennian carbonate mud mound complex worldwide, after the end-Frasnian mass extinction that wiped out numerous invertebrate taxa. [less ▲]

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See detailSharing in neuroimaging: collecting with Brainmap, quantitatively analysing and sharing with ANIMA
Genon, Sarah ULg; Reid, Andrew; Eickhoff, Simon

Conference (2015, September 14)

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See detailCorporate Board Attributes and CAC: A Comparative Study of France, Germany and UK
Boussaid, Nabila ULg; Hamza, Taher; Sougné, Danielle ULg

Conference (2015, September 14)

This paper investigates the impact of corporate board of directors’ attributes on conditional accounting conservatim in the French, German and British contexts. Using pooled regression model over the ... [more ▼]

This paper investigates the impact of corporate board of directors’ attributes on conditional accounting conservatim in the French, German and British contexts. Using pooled regression model over the period 2009-2012, our findings report that the relationship between corporate board attributes and accounting conservatism is country dependent. First, regarding the board composition, we find that the effect of board size is positive for German firms, negative for French firms and insignificant for British firms. We also document a positive association between board independence and accounting conservatism for British firms. However, we find no evidence of a positive association between codetermination and earnings conservatism in German context. Second, female seats on board seem to increase conservative reporting in financial statement only for French firms. Lastly, board meeting frequency in French and British firms appears to increase accounting conservatism. As a robustness test, we use an alternative measure of accounting conservatism namely, time–series of earnings changes measure and confirm the previous results. Overall, our results reveal that corporate board affects the financial reporting quality. [less ▲]

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See detailPt-Ni Hollow Nanoparticles for Oxygen Reduction Reaction : Controlling the Nanoparticle Morphology
Asset, Tristan ULg; Zubiaur, Anthony ULg; Chattot, Raphael et al

Poster (2015, September 13)

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See detail18FDG-PET/CT IMAGING IN SUSPECTED ACUTE RENAL ALLOGRAFT REJECTION
LOVINFOSSE, Pierre ULg; WEEKERS, Laurent ULg; BOVY, Christophe ULg et al

Conference (2015, September 13)

The diagnosis procedure for kidney transplant recipients (KTR) with suspected acute rejection (AR) relies on needle biopsy. Noninvasive tests to predict nonrejection would be preferable. AR is associated ... [more ▼]

The diagnosis procedure for kidney transplant recipients (KTR) with suspected acute rejection (AR) relies on needle biopsy. Noninvasive tests to predict nonrejection would be preferable. AR is associated with a recruitment of activated leukocytes into the transplant, which are characterized by a high metabolic activity and an increased uptake of glucose analog, Fluoro-deoxyglucose ( FDG). Thus, FDG-Positron emission tomography coupled with computed tomography (PET/CT) may help noninvasively distinguish nonrejection from AR. From January 2013 to February 2015, we prospectively performed 32 FDGPET/ CT in 31 adult KTR with suspected renal AR who underwent a biopsy. Biopsies were categorized as “normal”, “borderline”, “AR” or “others” according to Banff classification. PET/CT imaging was performed within 201 ± 18 minutes after i.v. administration of 3.2 ± 0.2 MBq/kg of FDG, before any modification of immunosuppression. The mean standard uptake values (SUV) of both upper and lower renal poles were measured, with no threshold activity. Biopsies were diagnosed as “normal”, “borderline”, “AR” or “others” in 8, 10, 8 and 6 (including 3 polyoma-BK nephropathies) cases. Mean SUV respectively reached 1.5 ± 0.2, 1.6 ± 0.3, 2.9 ± 0.8, 2.2 ± 1.2 in each category. Mean SUV of biopsy-proven AR was significantly higher than “normal” cases (p<0.01). No difference was found between “normal” vs. “borderline”, or between “AR” vs. “others” histopathology. Still, a positive correlation between mean SUV and acute composite (g+i+t+v+ptc) Banff score was found, with a coefficient of 0.70 (p<0.001). Sensitivity and specificity of FDG-PET/CT in detecting pathological biospies were respectively 92.3% and 36.8%, with a mean SUV threshold at 1.4. FDG-PET/CT imaging may help discriminate nonrejection, thereby avoiding unnecessary transplant biopsy in KTR with suspected AR. [less ▲]

Detailed reference viewed: 39 (8 ULg)
See detailNovel organocobalt for the synthesis of functional polymers
Demarteau, Jérémy ULg; Kermagoret, Anthony; Jérôme, Christine ULg et al

Poster (2015, September 11)

Organocobalt(III) with acetylacetonate (acac) ligands is the most representative example of R-Co bearing a labile C-Co bond that can release alkyl radicals under mild experimental conditions without ... [more ▼]

Organocobalt(III) with acetylacetonate (acac) ligands is the most representative example of R-Co bearing a labile C-Co bond that can release alkyl radicals under mild experimental conditions without requiring a photoactivation. The unique isolated R-Co is a short oligo(vinyl acetate) end-capped by Co(acac)2. The high lability of its C-Co bond combined to the unique capacity of Co(acac)2 to reversibly trap alkyl radicals make this R-Co unique for the precision design of unprecedented polymers by Cobalt-Mediated Radical Polymerization (CMRP). The growth of unstabilized and highly reactive growing radicals formed by the addition of R• to unconjugated vinyl monomers (vinyl esters, vinyl amides, vinyl imidazolium, vinyl chloride, etc;) is controlled by the reversible formation of a weak C-Co bond at the polymer chain end. The lack of alternatives to this R-Co, especially to the structure of the alkyl group, has however placed limitations on post-functionalizations of end-chains. Other functional variants that would enable attractive chain-end derivatizations are unfortunately not available. In this poster, we will address this important challenge by describing an innovative synthetic route towards the preparation of new functional R-Co(acac)2 that are sources of halomethyl radicals under mild experimental conditions. The efficiency of these novel organocobalt complexes for the precision synthesis of end-functional and telechelic polymers will be described. Also, the solubility of these complexes in water enables the facile production of end-functionalized water soluble poly(ionic liquid)s. Further derivatizations of the halomethyl group at the chain-end of polymers produced by this system will be demonstrated by click reaction, largely broadening the range of possible functional groups. Finally, besides numerous applications in macromolecular engineering, this unexplored family of R-Co presents a high potential in radical reactions in organic synthesis by the facile production of halomethyl radicals. [less ▲]

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See detailTentativi di avvicinamento a Il figlio di Bakunìn (1991) di Sergio Atzeni (1952-1995)
Curreri, Luciano ULg

Conference (2015, September 11)

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See detailL'utilisation des insectes dans la pharmacopée de l'Égypte gréco-romaine
Marganne, Marie-Hélène ULg

Conference (2015, September 11)

Telles qu'on peut les déchiffrer dans les papyrus littéraires grecs retrouvés en Égypte (IV/IIIe siècles avant notre ère – VI/VIIe siècles de notre ère), les prescriptions médicales recourent-elles à des ... [more ▼]

Telles qu'on peut les déchiffrer dans les papyrus littéraires grecs retrouvés en Égypte (IV/IIIe siècles avant notre ère – VI/VIIe siècles de notre ère), les prescriptions médicales recourent-elles à des insectes et, si tel est le cas, à quelle(s) variété(s), en raison de quelle(s) propriété(s) et pour quel(s) type(s) d'affections ? C'est à ces questions que l'on tentera de répondre, en complétant le témoignage des sources papyrologiques par celui des sources littéraires grecques et latines sur la pharmacopée de l'Égypte gréco-romaine. [less ▲]

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See detailCobalt-mediated radical polymerization for the precision design of novel poly(ionic liquid) copolymers in aqueous media
Cordella, Daniela ULg; Kermagoret, Anthony; Debuigne, Antoine ULg et al

Poster (2015, September 11)

Poly(ionic liquid)s (PILs) have emerged as a special class of polyelectrolyte materials, featuring tunable solubility, high ionic conductivity, and a broad range of glass transition temperatures. Due to ... [more ▼]

Poly(ionic liquid)s (PILs) have emerged as a special class of polyelectrolyte materials, featuring tunable solubility, high ionic conductivity, and a broad range of glass transition temperatures. Due to their specific properties emanating from the ionic liquid (IL) units and their intrinsic polymeric nature, PILs find potential applications in various areas, such as analytical chemistry, biotechnology, gas separation, dispersants, solid ionic conductors for energy, catalysis, etc. In recent years, controlled radical polymerization (CRP) techniques have been applied to the synthesis of structurally well-defined PILs, with control attained over molar mass, dispersity, and end-group fidelity. In this poster, we will report on the implementation of cobalt-mediated radical polymerization (CMRP) technique for the precision synthesis of unprecedented PILs (co)polymers. We will discuss how an organocobalt complex can efficiently control the growth of vinyl imidazolium chains and lead to PILs with predicted molar masses and low polydispersities under mild experimental conditions, thus at low temperature and using water as a green polymerization medium. The huge potential of this system will be highlighted by describing the one-pot synthesis of all vinyl imidazolium-based block copolymers in aqueous media. This CMRP is unique for providing well-defined vinyl imidazolium based-copolymers for advanced PILs applications. [less ▲]

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See detailGreen synthesis of polyphosphoesters, a promising class of bioinspired degradable materials
Lecomte, Philippe ULg; Baeten, Evelien

Conference (2015, September 11)

Detailed reference viewed: 22 (4 ULg)
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See detailPredator cues and risky habitats affect foraging activity in salamanders
Melotto, Andrea; Ficetola, Gentile Francesco; Denoël, Mathieu ULg et al

Conference (2015, September 11)

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See detailOptimized focal and pupil plane masks for vortex coronagraphs on telescopes with obstructed apertures
Ruane, Garreth; Absil, Olivier ULg; Huby, Elsa ULg et al

in Shaklan, Stuart (Ed.) Techniques and Instrumentation for Detection of Exoplanets VII (2015, September 11)

We present methods for optimizing pupil and focal plane optical elements that improve the performance of vortex coronagraphs on telescopes with obstructed or segmented apertures. Phase-only and complex ... [more ▼]

We present methods for optimizing pupil and focal plane optical elements that improve the performance of vortex coronagraphs on telescopes with obstructed or segmented apertures. Phase-only and complex masks are designed for the entrance pupil, focal plane, and the plane of the Lyot stop. Optimal masks are obtained using both analytical and numerical methods. The latter makes use of an iterative error reduction algorithm to calculate "correcting" optics that mitigate unwanted diffraction from aperture obstructions. We analyze the achieved performance in terms of starlight suppression, contrast, off-axis image quality, and chromatic dependence. Manufacturing considerations and sensitivity to aberrations are also discussed. This work provides a path to joint optimization of multiple coronagraph planes to maximize sensitivity to exoplanets and other faint companions. [less ▲]

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See detailWill Big Data Deliver its Promised Productivity Growth?
Artige, Lionel ULg

Conference (2015, September 11)

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See detailIntercalation of imidazolium end-functionalized polyphosphates between montmorillonite nanosheets towards flame-retardant
Carion, Stéphan ULg; Lecomte, Philippe ULg; Thomassin, Jean-Michel ULg et al

Poster (2015, September 11)

Among the additives used to impart flame-retardant properties to polymer materials, phosphorous additives and nanoclays are widely used. The aim of this work is to associate both additives to bring about ... [more ▼]

Among the additives used to impart flame-retardant properties to polymer materials, phosphorous additives and nanoclays are widely used. The aim of this work is to associate both additives to bring about a synergetic effect for improving the flame-retardancy of the material (1). In a first step, the synthesis of an aliphatic polyphosphate end-capped by an imidazolium cation is reported. Secondly, this polymer is intercalated between montmorillonite nanoclays. The strategy used for the synthesis of the polyphosphate is based on the ring-opening polymerization of the corresponding cyclic phosphate by using 1-(11-hydroxy-undecyl)-3-methylimidazolium bromide as an initiator. This polymerization was catalyzed by DBU and a thiourea derivative (2). This polymer was characterized by a set of techniques (31P and 1H NMR, SEC, TGA, DSC). Finally, the cationic end-functionalized polymer was exchanged with sodium cations present in montmorillonite. The intercalation of the polyphosphate between the clay nanosheets was proved by X-Ray Diffraction (XRD) and thermogravimetric analysis (TGA). This last technique was also used to determine the influence of the intercalation on the thermal stability of the polyphosphate. [less ▲]

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See detailCHEMOKINE (CC-MOTIF) LIGAND 2 AS A PROGNOSTIC SERUM MARKER IN CANINE IDIOPATHIC PULMONARY FIBROSIS
Roels, Elodie ULg; Holopainen, S.; Teske, Erik ULg et al

Poster (2015, September 11)

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See detailA Mach-Zehnder interferometer based on orbital angular momentum for improved vortex coronagraph efficiency
Piron, Pierre ULg; Delacroix, Christian; Huby, Elsa ULg et al

in Shaklan, Stuart (Ed.) Techniques and Instrumentation for Detection of Exoplanets VII (2015, September 11)

The Annular Groove Phase Mask (AGPM) is a vectorial vortex phase mask. It acts as a half-wave plate with a radial fast axis orientation operating in the mid infrared domain. When placed at the focus of a ... [more ▼]

The Annular Groove Phase Mask (AGPM) is a vectorial vortex phase mask. It acts as a half-wave plate with a radial fast axis orientation operating in the mid infrared domain. When placed at the focus of a telescope element provides a continuous helical phase ramp for an on axis sources, which creates the orbital angular momentum. Thanks to that phase, the intensity of the central source is canceled by a down-stream pupil stop, while the off axis sources are not affected. However due to experimental conditions the nulling is hardly perfect. To improve the null, a Mach-Zehnder interferometer containing Dove prisms differently oriented can be proposed to sort out light based on its orbital angular momentum (OAM). Thanks to the differential rotation of the beam, a π phase shift is achieved for the on axis light affected by a non zero OAM. Therefore the contrast between the star and its faint companion is enhanced. Nevertheless, due the Dove prisms birefringence, the performance of the interferometer is relatively poor. To solve this problem, we propose to add a birefringent wave-plate in each arm to compensate this birefringence. In this paper, we will develop the mathematical model of the wave front using the Jones formalism. The performance of the interferometer is at first computed for the simple version without the birefringent plate. Then the effect of the birefringent plate is be mathematically described and the performance is re-computed. [less ▲]

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See detailNumerical crashworthiness analysis of an offshore wind turbine monopile impacted by a ship
Bela, Andreea ULg

Conference (2015, September 11)

Detailed reference viewed: 17 (8 ULg)
Peer Reviewed
See detailCe que l'image fait à l'histoire
Havelange, Carl ULg

Conference (2015, September 11)

Detailed reference viewed: 18 (1 ULg)
See detailNew efficient organocatalytic system for solvent-free chemical fixation of CO2 into epoxides
Panchireddy, Satyannarayana ULg; Gennen, Sandro ULg; Alves, Margot ULg et al

Poster (2015, September 11)

Due to concerns about global warming combined with the decrease of fossil resources, the chemical transformation of carbon dioxide (CO2) into added-value products has gained interest in both academic and ... [more ▼]

Due to concerns about global warming combined with the decrease of fossil resources, the chemical transformation of carbon dioxide (CO2) into added-value products has gained interest in both academic and industrial fields. To date, the chemical fixation of CO2 onto epoxides with the formation of cyclic carbonates (CC) is one of the most promising ways to valorise CO2 at an industrial scale. Indeed, CC are useful monomers for polycarbonate synthesis and they can react with primary amines to produce 2-hydroxyethylurethane. This reaction can be extrapolated to the synthesis of non-isocyanate polyurethanes (NIPUs) by a step growth polymerization between bifunctional CC and diamines. [less ▲]

Detailed reference viewed: 91 (9 ULg)
See detail1. Actualités en ravageurs - 1. Saison 2015 : attaque et dégâts de cécidomyie orange du blé
Hautier, Louis; Chavalle, Sandrine ULg; De Proft, Michel

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2015, September 10)

Detailed reference viewed: 44 (4 ULg)
See detailDéception et incertitude en démocratie
Jamin, Jérôme ULg

Conference (2015, September 10)

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See detailDegradation of p-nitrophenol and bacteria with TiO2 xerogels sensitized in situ with tetra(4-carboxyphenyl)porphyrins
Tasseroul, Ludivine ULg; Lambert, Stéphanie ULg; Eskenazi, David et al

Poster (2015, September 10)

Heterogeneous photocatalysis is widely studied for environmental applications as oxidative processes can completely destroy organic pollutants such as alkanes, pesticides, dyes, etc. and microorganisms ... [more ▼]

Heterogeneous photocatalysis is widely studied for environmental applications as oxidative processes can completely destroy organic pollutants such as alkanes, pesticides, dyes, etc. and microorganisms. The most used photocatalyst is the commercial TiO2 Degussa P25, which is composed of 80% anatase and 20% rutile and which is active when TiO2 is exposed to UV light ( < 380 nm). Recently, several studies have been performed to extend the light absorption range of TiO2 towards the visible range. In this study, TiO2-based materials doped with porphyrins, a widely used dye for the photosensibilization of TiO2, have been prepared using a sol-gel process. To stabilize the TiO2-dye interactions, free metal tetra(4-carboxyphenyl)porphyrin and nickel tetra(4-carboxyphenyl)porphyrin were introduced in situ into the TiO2 matrix during the sol-gel process rather than by grafting. Samples were thoroughly characterized by TEM, X-ray diffraction, FT-IR, DR-UV/Vis and their texture has been examined by nitrogen adsorption–desorption at 77 K. The photocatalytic activity for the degradation of p-nitrophenol and Escherichia coli and Lactobacillus rhamnosus bacteria cells in aqueous medium, under halogen lamp light have been evaluated in relation with the physico-chemical modifications induced by the doping. The low temperature vacuum drying protocol (150°C) used in the present study enabled to obtain porphyrin doped TiO2 xerogels with a high specific surface area, and containing nanoparticles composed of amorphous- and anatase-TiO2. Diffuse reflectance spectroscopy attest the presence of TCPPH2 and TCPPNi within the TiO2 matrix. In a first step, the photoactivity of the xerogels is tested for p-nitrophenol degradation. Results show that crystallinity and nature and concentration of porphyrin introduced in situ have major impact on the degradation performances. In a second step, the best xerogel for p-nitrophenol degradation has been used to degrade bacteria. This xerogel degrades E. coli and L. rhamnosus bacteria cells in less than 48 and 24 h respectively. The photocatalytic degradation of a pollutant is thus correlated to the degradation of bacteria since a xerogel doped with the TCPPNi degrades both p-nitrophenol, E. coli and L. rhamnosus. [less ▲]

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See detail2. Implantation des cultures
Eylenbosch, Damien ULg; Meza Morales, Walter ULg; Monfort, Bruno et al

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2015, September 10)

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See detailOsteopontin as a new target in glioblastoma progression and resistance to radiotherapy
Henry, Aurélie ULg; Bellahcene, Akeila ULg; Castronovo, Vincenzo ULg et al

Conference (2015, September 10)

Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These treatments ... [more ▼]

Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These treatments include maximal surgical resection, radiotherapy and concomitant or adjuvant chemotherapy with Temozolomide (TMZ). However, the prognosis of adult patients with GBM remains poor and the survival outcome after treatment does not exceed 15 months. Glioblastoma-composing cells have developed many strategies to counteract these current therapies. Among the wide hallmarks acquired to survive, osteopontin (OPN) ranks correlates with lower overall and disease-free/relapse-free survival in all tumors combined, as well in brain cancer. OPN expression is largely considered as a molecular cancer marker associated with poor prognosis for patients with cancer. Our preliminary works (Lamour V and Henry A, IJC 2015) have demonstrated the role of OPN in the tumorigenicity of glioblastoma cells and its importance in the maintenance of the stem charachters. Within the continuance of this work, our recent studies focused on the potential role of OPN in the resistance of glioblastoma cells to radiotherapy and its implication in the initiation of Double Strand Breaks (DSBs) repair mechanism. In this context, U251-MG and U87-MG cells were used to assess the role of OPN in the initiation of the DSBs repair mechanism after an exposure to gamma-irradiation (γ–IR). The transient transfection of both cell lines with siRNA directed against OPN shown a lower induction of γ–H2AX compared to control (irrelevant siRNA). The survival of U251-OPN depleted cells was also affected after an exposure to γ–IR (based on clonogenic assays). However, the sole depletion of OPN in U87 cells affected their survival (independently of the γ–IR). To prove that the secreted form of OPN is necessary to survive after γ–IR, conditionned medium of U87-shSCR clones (rich in OPN) was used to treat U87shOPN clones before an exposure to γ–IR. By immunofluorescence, we observed that the γ–H2AX staining was higher in U87 shOPN clones than when treated with their own conditionned medium (poor in OPN). Currently, we are investigating the in vivo implication of OPN in the initiation of DSBs repair mechanism after an exposure of mice to γ–IR (whole brain exposure). For this purpose, IPTG-inducible U87 shRNA clones (SCR and OPN) have been generated and validated for an orthotopic xenograft model in NOD-SCID mice. The survival after a radiotherapy of 10 Gy (2Gy per day for 5 days) will be assessed in OPN-positive and –negative tumor-bearing mice. Taken together, these datas suggest that OPN could represent an important pronostic factor for patient response to radiotherapy in the context of GBM. [less ▲]

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See detail1. Actualités en ravageurs - 2. Variétés résistantes à la cécidomyie orange du blé : intérêt agronomique et méthode de caractérisation
Chavalle, Sandrine ULg; Jacquemin, Guillaume; De Proft, Michel

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, September 10)

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See detail6. Protection intégrée des semis et des jeunes emblavures
Henriet, François; Chavalle, Sandrine ULg; Bataille, Charlotte et al

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2015, September 10)

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Peer Reviewed
See detailChallenges for Scale-Up of Batch Phase Separation
Pfennig, Andreas ULg; Becker, Karsten; Bach, S. et al

Conference (2015, September 10)

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Peer Reviewed
See detailNewts skip aquatic life and forego reproduction in response to alien fish introduction
Winandy, Laurane ULg; Darnet, Elodie; Denoël, Mathieu ULg

Conference (2015, September 10)

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See detailNumerical simulations on embedded solids : integration of CAD and eXtended Finite Element Analysis
Duboeuf, Frédéric ULg; Béchet, Eric ULg

Conference (2015, September 10)

The aim of this communication is to propose a procedure in order to dissociate the geometric description of the field’s approximation within the extended finite element method (X-FEM) and with non ... [more ▼]

The aim of this communication is to propose a procedure in order to dissociate the geometric description of the field’s approximation within the extended finite element method (X-FEM) and with non-matching meshes. Implicit and explicit approaches are combined in order to represent with accuracy all the CAD entities regardless of their dimension. The choice of appropriate tools such as Level Sets technique allows to describe evolving interfaces with great flexibility. The design of a dedicated P1 functional space is achieved by decimating the traces of standard finite element (FE) shape functions, thanks to a new algorithm, especially when the problem domain is embedded in a space of a higher dimension. An analysis of the approximation properties of the P1 FE trace spaces on hyper-surfaces is available in the literature and applied for solving PDEs on closed surfaces without boundary. Dirichlet boundary conditions are applied using a convenient choice of stable Lagrange multiplier space, according to a new generalized algorithm. That extends the existing solutions to every combination of the space domain and boundary dimensions. In terms of solvers, the introduction of double Lagrange multipliers can be used to recover the positive definiteness of the bilinear form. This approach allows to treat any embedding, i.e. 1, 2, or 3D problems embedded in 2 or 3D background meshes. The possibility of applying the methodology to beams is investigated, with a potential application to through-thickness reinforced composites in a mixed-dimensional modelling framework. [less ▲]

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See detail3. Variétés - 1. Froment d'hiver
Meza Morales, Walter ULg; Eylenbosch, Damien ULg; Jacquemin, Guillaume et al

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2015, September 10)

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