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See detailIdentifying novel biomarkers for the rapid diagnosis of invasive aspergillosis using GC×GC-TOFMS
Stefanuto, Pierre-Hugues ULiege; Rees, Christiaan A.; Beattie, Sarah R. et al

Conference (2017, May)

Aspergillus fumigatus is a filamentous fungus responsible for the life-threatening infection, invasive aspergillosis (IA), in immunocompromised individuals. Currently, IA diagnostic methods take days to ... [more ▼]

Aspergillus fumigatus is a filamentous fungus responsible for the life-threatening infection, invasive aspergillosis (IA), in immunocompromised individuals. Currently, IA diagnostic methods take days to produce a result and methods to obtain samples are invasive. One approach to improve the time-to-diagnosis is based on utilizing our knowledge of fungal metabolism during pathogenesis. Recent studies have demonstrated the importance of oxygen availability during IA, which presents a potential diagnostic opportunity. In this study, we analyzed the early (1 hr) and late (8 hr) volatile profile of A. fumigatus strain CEA1o under oxygen replete (~20% O2) and deplete (0.2% O2) conditions. In order to comprehensively screen the headspace of these cultures, we applied headspace solid phase microextraction (HS-SPME) associated with comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry (GC×GC-TOFMS). Comparing the headspace of the four culture conditions, we were able to identify specific volatile biomarkers of low oxygen fungal growth: ethanol, acetaldehyde, 2-propanol, 2,3-butanedione, and 3-hydroxy-2-butanone. Based on the putative identifications of these compounds, we identified potential metabolic pathways that are responsible for their production. The two first compounds are known to be produced during hypoxia metabolism of glucose, however, the three others suggest that previously uncharacterized metabolic pathways may be utilized by A. fumigatus in low oxygen conditions. Validation of these biomarker identities and translation into patients may generate metabolic insight into these organisms during IA pathogenesis. [less ▲]

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See detailInfluence qualitative et quantitative du mode de séchage sur l'huile essentielle de Thymus fontanesii de l'Algérie
Sidali, Lamia; Brada, Moussa; Fauconnier, Marie-Laure ULiege et al

Poster (2017, May)

Cette étude a pour but d`étudier l`influence du mode de séchage (à l’ombre et au soleil) sur le rendement et la composition chimique de l`huile essentielle de Thymus fontanesii de l`Algérie obtenue par ... [more ▼]

Cette étude a pour but d`étudier l`influence du mode de séchage (à l’ombre et au soleil) sur le rendement et la composition chimique de l`huile essentielle de Thymus fontanesii de l`Algérie obtenue par extraction assistée par induction électromagnétique. Les résultats ont montré que le séchage à l`ombre a donné un meilleur rendement de (1.12%) après une période de séchage de 10 jours jusqu`à la stabilisation de teneur en eau, alors que le séchage au soleil pendant 8 jours donne un rendement de (0.89%). La composition chimique de l`huile essentielle de Thymus fontanesii (TF) a été analysé par la chromatographie en phase gazeuse couplée à la spectrométrie de masse (GC/MS) et la chromatographie en phase gazeuse a ionisation de flamme (GC/FID). [less ▲]

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See detailTreatment MEthodology and MOnitoring for sequenced Reallocation of severely polluted Industrial Sites (MEMORIS) project
Duprez, Marie-Eve; Castro, Cristiana; Devalckeneer, Aude et al

Poster (2017, May)

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See detailBasic Helix loop Helix transcription factor twist1a and twist1b and their involvement in the skeletal development of zebrafish.
Zappia, Jérémie ULiege; Windhausen, Thomas ULiege; Renn, Jörg ULiege et al

Poster (2017, May)

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to ... [more ▼]

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to be mutated in cases of the Saethre–Chotzen syndrome (SCS). However, the roles of these genes in skeletal development in zebrafish remain to be clarified. The aim of our research is to characterize the effects of the knock-down of twist1a and twist1b in the zebrafish. 2. Methods Antisens morpholino are used for the knock-down of twist1a and twist1b (respectively MoTwist1a and MoTwist1b). The sox9a expression is investigated using whole amount in situ hybridization. 3. Results We show the spatio-temporal expression pattern of twist1a and twist1b during the first 6 days of zebrafish development and present the effects observed on cartilage and bone formation upon knock-down of these genes in zebrafish larvae. The results reveal a decrease of the cranial cartilage and bone formation in both MoTwist1a and MoTwist1b. Interestingly, when MoTwist1a and MoTwist1b are co-injected, the cranial cartilage formation is strongly reduced, while ectopic cartilage formation appeared in the front of the head. We also show an increase in expression of sox9a, a master regulator of chondrogenesis, in morphants. 4. Summary and Conclusions Even though it was shown that twist1a and twist1b maintain a pool of osteoprogenitor-like cells, we show that a knock-down of these genes induces a decrease of skeletal formation. Our hypothesis is that the morphants run out of progenitor cells to assure correct bone and cartilage formation. In the future, we plan to generate twist1a mutants in order to further characterize the effect of this mutation. The twist1a mutant will eventually serve for a rescue study using human TWIST1 mRNA, wild-type or mutant in order to have a better understanding of the human disorder SCS. [less ▲]

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See detailEcomorphology of the axial skeleton in Odontocetes and Mysticetes
Gillet, Amandine ULiege; Parmentier, Eric ULiege

Poster (2017, May)

Ecomorphology concerns the study of the relationships between functional design and the environmental constraints acting on organisms. It aims to understand how the morphological variations among species ... [more ▼]

Ecomorphology concerns the study of the relationships between functional design and the environmental constraints acting on organisms. It aims to understand how the morphological variations among species can be related to environmental factors and impact fitness. Having a large diversity both in their morphology and ecology, the cetacean taxa appears to be the ideal taxa to tackle the relationships between the locomotor system and way of life. Different studies have already showed that the number and shape of vertebrae in different cetaceans can reflect the stiffness of the body and consequently can impact their swimming mode. The aim of this study is to establish relationships between characteristics of the vertebral column of different cetaceans and their ecology. Meristic and morphometric data were collected on the vertebrae (centrum lengths, heights and widths, neural spine heights and transverse processes lengths) of species of odontocetes housed in different Natural History Museums in the world (AM-ULg, RBINS, MNHN, SMNS, NRM, Queensland, PEM, Iziko). Preliminary results show clear morphological variations between species at the level of the number and sizes of vertebrae. There is a clear relationship between body size and number of vertebrae except in Delphinidae. This family has an important higher vertebral count. These differences should be related to different swimming modes and reflect the different ecological behaviours of the studied cetaceans. [less ▲]

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See detailNew identification of energy levels in the astatine atom, the rarest element on Earth
Quinet, Pascal ULiege; Sicorello, G.

Poster (2017, May)

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See detailProcess intensification of the synthesis of glycerol carbonate under microwave irradiation or continuous-flow conditions
Estager, Julien; Pleck, Julie; Gerardy, Romaric ULiege et al

Conference (2017, May)

Despite low crude oil prices and the increasing access to shale gas, the establishment of a biobased economy remains a worldwide priority. An integrated biobased economy would not only consider renewable ... [more ▼]

Despite low crude oil prices and the increasing access to shale gas, the establishment of a biobased economy remains a worldwide priority. An integrated biobased economy would not only consider renewable biobased resources to provide industrially relevant chemicals, but would also redefine chemical processing by using greener, safer and more selective process technologies. The last few decades have witnessed the emergence of promising alternative energy sources such as microwave irradiation and alternative process technology such as continuous-flow reactors. Even if biobased chemicals are still marginal on the marklet compared to petrochemicals, many biorefineries are now able to convert biomass into biobased chemical building blocks of good purity on large scales. Amongst these products, glycerol – a side product of the biodiesel industry – is a particularly appealing chemical platform thanks to its high functionality and its wide availability. Various high-value added chemicals can be obtained from glycerol, among which glycerol carbonate retained our attention. Glycerol carbonate is an attractive glycerol derivative that can be used in many applications ranging from low-VOC solvent to polymer synthesis. Many publications describe its synthesis using different catalysts or alternative activation methods such as microwave. Our research effort in process intensification for the industrial valorization of biomass led us to develop an intensified carbonation process of glycerol under microwave irradiation, affording an unprecedented reactivity with short reaction times and high selectivity towards glycerol carbonate. Based on this preliminary study, and using the microwave-to-flow paradigm, continuous-flow processes using mesofluidic reactors have been developed to obtain glycerol carbonate in good yield and high purity. [less ▲]

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See detailPlatelet-rich plasma versus hyaluronic acid to treat patellar tendinopathies
Kaux, Jean-François ULiege; Roberjot, Mathieu; SAMSON, Antoine ULiege

in The Future of Football Medicine (2017, May)

Introduction: The treatment of patellar tendinopathies could be difficult. This is the reason why new treatments have been developed, among which platelet rich plasma (PRP) injections. Some clinical ... [more ▼]

Introduction: The treatment of patellar tendinopathies could be difficult. This is the reason why new treatments have been developed, among which platelet rich plasma (PRP) injections. Some clinical series have previously evaluated the effect of PRP in the treatment of proximal patellar tendinopathies. Recent systematic review concluded that PRP could be recommend as a treatment in such indication (1). Recently, the viscoelastic properties of hyaluronic acid (HA) on liquid connective tissue have been proposed for the treatment of tendinopathies (2). Some fundamental studies show encouraging results on HA’s ability to promote tendon gliding and reduce adhesion as well as to improve tendon architectural organisation. Some observations also support its use in a clinical setting to improve pain and function. Purpose: We aimed to compare the effect of PRP injection versus two injections of HA after three months on patients who have a proximal patellar tendinopathy. Methods: Eleven leisure football players with proximal patellar tendinopathies being not relieved after minimum three months of physiotherapy treatments where included. Six of them (group 1: 29.5±9.9 y.o.; 78.9±12.8kg; 177.4±6;9cm) have received a leukocyte poor PRP injection (obtained using an aphaeresis machine) under US guidance. This technique of PRP collection enable to obtain reproducible pure PRP with the same chosen concentration of 850 000 platelets/microliter. The other five subjects (group 2: 29.3±8.1 y.o.; 77.1±10.6kg; 178.1±5.8cm) received two HA 2% (40mg/2mL) injections (2mL) at one week apart. All of them have benefited of standardized rehabilitation, 3 times a week. Concerning the evaluation of the pathology, algo-functional tests (visual analogic scale (VAS), pressure algometer, IKDC score, VISA-P score), isokinetics (Cybex Norm; concentric 60°/s (C60), concentric 240°/s (C240) and eccentric 30°/s(E30)) associated to VAS, along with the patellar tendon ultrasonography (US) have been realized over three times (pre-injection, after 6 weeks, after 3 months post-injections). Results: The results of VAS (p<0,01), algometric scores (p<0,01), IKDC scores (p<0,01) and VISA-P (p<0,01) show a considerable improvement in the two groups, but not for the US findings. For the group 1 (Table 1), isokinetic tests show significant results for the hamstrings in C60°/s with an improvement of maximum peak torque (p=0,01) for the pathological limb, a diminution (p>0,05) for the healthy limb and during the analysis of the bilateral difference (p=0,0002). For the group 2, the improvement of quadriceps maximum peak torque in C240°/s is significant (p>0,01) for the pathological knee after 6 weeks post-injections only. The VAS associated with isokinetic tests decreases significantly for all contraction modes after three months of study. Conclusions: Both PRP and HA can improve the symptoms of proximal patellar tendinopathy, even if the results are slightly better in the PRP group. [less ▲]

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See detailImpact on athletic performance of an early return to play following an ACL rupture
Duval, Thomas; LEHANCE, Cédric ULiege; DANIEL, Christophe ULiege et al

in The Future of Football Medicine (2017, May)

Introduction and purpose: The rupture of the anterior cross ligament (ACL) is the most frequent knee injury incurred during participation in sports and especially in football. Typically, the injured ... [more ▼]

Introduction and purpose: The rupture of the anterior cross ligament (ACL) is the most frequent knee injury incurred during participation in sports and especially in football. Typically, the injured athlete must undergo a surgical reconstruction of the ligaments followed by a lengthy rehabilitation period. However, the timeline for return to competition after this operation remains a challenge. More than one third of the athletes are unable to go back to sport performing at the same level prior to the injury. Approximately 65% of patients who experience this injury are able to return to sport at the same level. The fear of undergoing a new accident remains a major hurdle with this sporting recovery and the persistence of functional deficits is the first cause of repetitive ligament injuries. A reathletization program guided by strength and conditioning coaches results in a greatly reduces the risk of recurring injury by approximately 66% Methods: Our study involved a randomized control test. Our sample included ten subjects, five in the experimental group and five in the control group. Beginning one month post-surgery, the first group participated in weekly reathletization session beginning one week post-operation, associated with rehabilitation in classical physiotherapy, over a period of six months. The second participated solely in standard physiotherapy. Both groups were subjected to an initial isokinetic test as a base measurement to track improvement. After six months, the subjects of the two groups were evaluated using the following tools: an isokinetic test, a questionnaire of KOOS and finally a Hop tests. Results: The analysis of the isokinetic test and the questionnaire of KOOS ( p= 0.30) enabled us to note differences between the two groups using quantified values; however, the results were significant. On the other hand, the analysis of the results obtained through the functional tests showed significant differences between the two groups, highlighting the increased performance and benefit for the group participating in weekly reathletization. The experimental group displayed results in the three jump tests which indicates a greater strength and recovery. For the single hop test and the triple hop, the result is p = 0.04, and for the cross over test, the result is p = 0.02. Conclusion: In our preliminary study, the quantified values for both groups indicated a greater improvement in the performances of the experimental group reathletization. Although during the statistical analysis and especially in the isokinetic test, few elements significantly evolved to see any for the questionnaire KOOS. The preliminary analysis warrants an experiment involving a larger subject pool be completed. A reathletisation program beginning one month after operation has been found to limit the nuisances and long period of inactivities (weight increase, losses of muscular force, decrease of aerobic performances) typically experienced by those who rupture the ACL. This program has been found to be especially effective when coupled with regular physiotherapy meetings. [less ▲]

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See detailExperimental investigation and dynamic modeling of an air-to-water residential heat pump with vapor injection and variable speed scroll compressor
Dechesne, Bertrand ULiege; Gendebien, Samuel ULiege; Lemort, Vincent ULiege et al

in 12th IEA Heat Pump Conference Proceedings (2017, May)

This paper presents experimental results of a residential air source heat pump using a scroll compressor with variable speed and vapor injection. The system is modeled using the Modelica language and a ... [more ▼]

This paper presents experimental results of a residential air source heat pump using a scroll compressor with variable speed and vapor injection. The system is modeled using the Modelica language and a comparison with the experimental results is performed. It was shown that there is still room for improvement on the control of the system. In fact, the tested gain scheduled PID controller showed limitation to maintain a low and steady superheat on both the suction and injection lines due to dynamics associated to the vapor split line or heat exchangers. The presented model of the system could be used in order to develop model based control and increase the system performances. [less ▲]

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See detailCan any possible combination of modes improve intermodal attractiveness?
Mostert, Martine ULiege; Caris, An; Limbourg, Sabine ULiege

in Proceedings of the BIVEC-GIBET Transport Research Days 2017 (2017, May)

In its White Paper on Transport, the European Commission recognizes intermodal transport as an alternative solution to road transport. In practice, intermodal transport can be constituted by any ... [more ▼]

In its White Paper on Transport, the European Commission recognizes intermodal transport as an alternative solution to road transport. In practice, intermodal transport can be constituted by any combination of modes, while in the literature, intermodal transport is often modeled as a combination of modes in the order “road-rail/inland waterway-road”. This work develops a new intermodal allocation model which allows choosing between any direct (road, rail and inland waterways) transport and any intermodal transport chain constituted by up to three modes of transport. Intermodal solutions can pass through one or two intermodal terminals. Applied on experimental data at the European level, the model gives insight on the optimal flow distribution for economic objectives (optimization of transport operational costs) and environmental objectives (optimization of transport CO2 emissions and air pollution external costs). Results highlight that the traditional modeling of intermodal transport as a “road-rail/inland waterway-road” combination better fits economic than environmental objectives. [less ▲]

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See detailPlasma effects on the atomic structure and X-ray lines of astrophysical interest in oxygen ions
Deprince, J.; Palmeri, P.; Quinet, Pascal ULiege et al

Poster (2017, May)

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See detailEffect of changing size and composition of a crop model ensemble on impact and adaptation response surfaces
Rodríguez, A.; Ferrise, R.; Ruiz-Ramos, M. et al

in Book of Abstracts - MACSUR2017 Scientific Conference (2017, May)

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See detailEvaluation of the implementation of integrated care for people with chronic conditions
Van Durme, Thérèse; Anthierens, Sibyl; Van Hecke, Ann et al

Conference (2017, May)

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See detailComparison of rapid protein structure determination approaches driven by experimental NMR data
Wanko Nembot, Alexis Marius ULiege

Poster (2017, May)

The knowledge of the tridimensional structure of a protein is essential to design drugs, to predict protein function and to study mechanism of protein function. 3D structure can be determined using two ... [more ▼]

The knowledge of the tridimensional structure of a protein is essential to design drugs, to predict protein function and to study mechanism of protein function. 3D structure can be determined using two experimental techniques: X-Ray and NMR. However, these techniques have limitations: they are time consuming, manually intensive and sometime technically difficult. Due to these limitations, different approaches that combine the strength of computer and sparse experimental NMR data have been proposed to determine rapidly 3D protein structure. Thus different approaches that use sparse NMR experimental NMR data such as backbone chemical shifts, incomplete sets of NOEs distances and residual dipolar couplings of backbone have been designed. To assess whether if these automated methods can indeed produce structures that closely match those manually refined by experts using the same experimental data, Critical Assessment of Automated Structure Determination of Proteins from NMR Data [1] (CASD-NMR) was created. CASD-NMR concept closely resembles to Critical Assessment of Automated Structure Prediction [2] (CASP) that aim to assess performance of protein structure prediction methods from sequence. Accordingly to CASD-NMR 2013 [3] recommandations, we are working on the comparison of different automated protein structure determination methods driven by backbone chemical shifts and homology modeling in terms of the fitness of resulting 3D structures with experimental NMR data. For homology modeling, we have been using two approaches: I-TASSER [4] and MODELLER [5] that are best public CASP-certified protein structure prediction servers. Structure calculation guided by NMR backbone chemical shifts were done using different approaches: (i) ROSETTA method that is widely used by the scientific community. Different rosetta based methods exist that used only backbone chemical shifts as experimental data. Moreover, ROSETTA method is probably the most backbone chemical shifts based structure calculation method used and cited by the community. For our comparison, three ROSETTA-family methods have been used: CS-ROSETTA [6], CS-HM-ROSETTA [7] and RASREC CS-ROSETTA [8]. (ii) Cheshire which is the first backbone chemical shifts based method which performed as well as CS-HM-ROSETTA during CASD-NMR-2013, and (iii) CS23D which is a web server that performed 1000-10,000 times faster than competing methods (Cheshire [9] and CS-Rosetta). Each of these approaches were used to determine 3D structure of a benchmark of 50 proteins. These 50 proteins were randomly selected within proteins for which NMR backbone chemical shifts are available in the BMRB data bank excluding proteins that have been used during CASD or CASP. In addition, we will applied these methods on cold shock proteins for which we have our own experimental data. [less ▲]

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See detailPreserving the Story of Heritage in Ruins Using Online Digital Repositories; The Case of Urbex
Eisazadeh, Negin ULiege; Bordalejo, Barbara

Conference (2017, May)

Urban explorers have for some time been producing informal iconographic and textual records of manmade structures which because of being abandoned or inaccessible for the general public, are not usually ... [more ▼]

Urban explorers have for some time been producing informal iconographic and textual records of manmade structures which because of being abandoned or inaccessible for the general public, are not usually in the public eye and are often in a state of deterioration and in danger of being destroyed. This interdisciplinary research which connects the fields of architecture, history, conservation, and digital humanities, looks into the materials recorded by the urban exploration (urbex) community and investigates their potential for the protection and documentation of decaying or demolished abandoned architectural heritage sites. For the management and dissemination of heritage information for the abandoned sites, more specifically, the recently demolished Château de Noisy, a famous urbex destination in Belgium, this study explores and builds upon the existing digital resources and looks into various tools and techniques to compile, curate and present this data to narrate the story of abandoned heritage sites. Additionally, through visualisation of data collected, cleaned, and compiled using the Flickr application programming interface (Flickr API) and Python, the changes in the urbex community’s activity since their debut on Flickr are observed. This research shows the value of the existing urbex digital data for documentation and potential conservation of abandoned heritage sites and demonstrates how a mindful digital narration of even a demolished heritage site can create an engaging and immersive experience which records and preserves the heritage and its story. Additionally, it can raise public awareness which in the case of deteriorating abandoned sites can lead to their potential revival. [less ▲]

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See detailX-ray tomography : a tool for revealing local distribution of liquid in structured packed columns
Toye, Dominique ULiege

Conference (2017, May)

Presentation of the x-ray tomography setup and of the experimental results relative to the fluid distribution and to the flow morphology in a column packed with high performance packing (Mellapak 752Y ... [more ▼]

Presentation of the x-ray tomography setup and of the experimental results relative to the fluid distribution and to the flow morphology in a column packed with high performance packing (Mellapak 752Y). The influence of liquid flowrate and of liquid viscosity is addressed. Results are used to get information required to model the mass-transfer performance in the column. [less ▲]

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See detailHow to manage a case of ischial tuberosity avulsion fracture?
Tyberghein, Maëlle; Kaux, Jean-François ULiege; GODON, Bernard ULiege et al

in The Future of Football Medicine (2017, May)

Introduction Apophyseal avulsion fractures of the pelvis are common among teenage football player. Usually, they are the result of a sudden forceful concentric or eccentric contraction of the muscle ... [more ▼]

Introduction Apophyseal avulsion fractures of the pelvis are common among teenage football player. Usually, they are the result of a sudden forceful concentric or eccentric contraction of the muscle attached to the apophysis. Indeed, before ossification, the apophyseal growth cartilage is the weakest point in the musculotendinous unit, making the apophysis vulnerable to injure. Athletes most commonly affected are soccer players when they tackle or shot powerful at goal and gymnasts during floor exercises which imposed sudden and excessive lengthening. Management of these fractures remains unclear. There are no guidelines between conservative and surgical approach even if most publications recommend a surgery if the diastasis exceeds 2cm and a conservative approach on the other hand. Case report A sixteen-year-old high-level player presented at the consultation with right ischial pain. Three months earlier, while he was sprinting, he had felt acute pain opposite the ischial tuberosity which compelled him to stop the training. He had already consulted another physician, who prescribed an X-ray which revealed an avulsion fracture of the ischial tuberosity with a maximal diastasis of 1.9 cm (Fig 1.a.). According to most publications (1,3), surgery is advisable from 2 cm of diastasis. 1.9 cm was within the range between a surgical and a conservative approach, and the conservative one was applied. An isokinetic assessment was planned. It highlighted hamstring strength imbalances with bilateral difference of 31% in concentric strength and 28% in eccentric strength in comparison with the healthy side. The mixed ratio of the hamstrings in eccentric mode at 30°/s to quadriceps in concentric mode at 240°/s was decreased to 0.8, while the lower limit in our clinical practice corresponded to 0.9. The patient was not allowed to resume competition and a rehabilitation by specific and progressive strengthening in both modes of contraction was initiated; in particular the eccentric training was initially submaximal and progressively intensified. Six weeks later, isokinetic assessment was repeated and showed significant improvement of right hamstring strength, particularly for eccentric contraction. The greatest improvement was the mixed Hecc/Qconc ratio wich had increased from 0.8 to 1.44. In regard to radiology, we observed no change since the previous X-Ray (Fig 1.b.). Intensified training on the field was allowed in order to resume competition. Less than one year after the injury, the patient restarted competition successfully with performance levels which were almost the same as before the injury. Discussion Many publications have discussed the surgical versus the conservative approach to treating ischiatic avulsion. Most of the published literature advocate the relevance of surgery when the diastasis exceeds 2 cm because widely displaced fractures may lead to chronic symptomatology if the treatment remains conservative. Different criteria, such as pain relief, ability to perform in sport, gross strength, activity score, X-Rays, are used by authors to demonstrate the recovery after treatment. No study accurately measured the hamstring strength before and after treatment. However, strength imbalance, especially as regards the H/Q mixed ratio, significantly increases the risk of sustaining hamstring injury in soccer player (2). For our patient, the rehabilitation enabled him to re-establish hamstring strength in six weeks with substantial improvement of eccentric assessment. The mixed Hecc/Qconc ratio increased from 0.8 to 1.44. This improvement significantly decreased the risk of recurrence of hamstring injury. Regarding X-Ray imagery, there was no evidence of healing. We advocate that radiological assessment should not be the main recovery criterion and that specific strengthening should be started even when avulsion persists on the X-Ray. Furthermore, hamstring strength should be measured accurately and objectively, e.g. by isokinetism, to be one of the main return to play criterion in association with clinical data. [less ▲]

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See detailL’hospitalisation sous contrainte : Urgences psychiatriques et mises en observation.
Schmits, Emilie ULiege; Evrard, Maude; Valassopoulou, Eftychia et al

Poster (2017, May)

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See detailUltrasonic spray coating of electrochromic nanomaterials
Maho, Anthony ULiege; Manceriu, Laura ULiege; Colson, Pierre ULiege et al

Conference (2017, May)

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See detailA surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
Farhat, Khalil ULiege; Bodart, Gwennaëlle ULiege; Renard, chantal et al

Poster (2017, May)

In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a ... [more ▼]

In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a consensus about GH immunomodulatory properties. These studies investigated the immune and anti-infectious response of dwarf Ghrh-/- mice presenting a severe deficiency of the GHRH/GH/IGF-1 axis. In basal conditions, thymic parameters and T-cell responses of Ghrh-/- mice were not severely affected but a constant B-cell lymphopaenia was observed. Thus, we investigated vaccine and anti-infectious responses of Ghrh-/- mice toward Streptococcus pneumonia, a B-dependent pathogen, Ghrh-/- mice were unable to trigger production of specific IgM and IgG against serotype 1 pneumococcal polysaccharide (PPS) after vaccination with either native PPS (Pnx23) or protein-PPS conjugate (Prev-13) vaccines. These vaccines both include the serotype 1 (our S.pneumoniae strain) and provide an effective protection in mice. A short GH supplementation to Ghrh-/- mice (1 daily injection of 1 mg/kg GH for 4 weeks) restored IgM and IgG response to Pnx23 vaccine but not to Prev-13. This suggests that GH could exert distinct impacts upon spenic areas. Furthermore, after intranasal instillation of a non-lethal dose (defined by the full clearance by WT C57BL/6 mice after 24h) of serotype 1 S.pneumoniae, Ghrh-/- mice exhibited a dramatic susceptibility. This was proved by a marked time-dependent increase in pulmonary bacterial, a septicemia already 24h after infection and a survival limit of 72h. We also observed a dramatic decrease in lung B- and T-cell populations and an increase in proportion of inflammatory macrophages. By contrast, wild-type and heterozygote mice completely cleared S.pneumoniae infection after 24h. In conclusion, our data show without ambiguity that the somatotrope GHRH/GH/IGF-1 axis plays an important and unsuspected role in defense against S.Pneumoniae. [less ▲]

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See detailIsokinetic profil of subjects with proximal patellar tendinopathy
Croisier, Jean-Louis ULiege; Roberjot, Mathieu; DELVAUX, François ULiege et al

in The Future of Football Medicine (2017, May)

Introduction: Proximal patellar tendinopathy is relatively common among sportsmen, even among football players who do repetitive shooting sessions. However, the strength profile of subjects with proximal ... [more ▼]

Introduction: Proximal patellar tendinopathy is relatively common among sportsmen, even among football players who do repetitive shooting sessions. However, the strength profile of subjects with proximal patellar tendinopathies is rarely described and the isokinetic profile remains unknown. Purpose: We aimed to determine the strength profile of subjects suffering from this frequently recurrent pathology. Methods: Forty-three players (29,1±8.5 y.o.; 78.1±11.9kg; 179.3±7.2cm) with chronic proximal patellar tendinopathy confirmed by ultrasounds were recruited. Quadriceps and hamstrings muscular performances of the healthy and pathological side were measured using an isokinetic dynamometer (Cybex Norm) at the concentric speed of 60°/s (C60) and 240°/s (C240) and at the eccentric speed of 30°/s (E30 - only for hamstrings). A visual analogic scale of pain (VAS) has also been used after each isokinetic test in order to associate the level of complaints and the intensity of contractions. Results: The results (Table 1) for the isokinetic tests comparing the healthy (HS) to the pathological side (PS) are significant for the different conditions of contraction and test speeds, as for the results of the VAS associated to those tests (p<0.01). Indeed, pathological limbs had a maximum peak torque for the quadriceps at C60 and at C240 lower than healthy limbs (2.17 ± 0.68 N.m/kg vs 2.47 ± 0.55 N.m/kg, p = 0.0003 and 1.46 ± 0.42 N.m/kg vs. 1.56 ± 0.31 N.m/kg, p = 0.02, respectively); this represents a bilateral difference of 14% for C60 and 7% in C240. In E30, pathological limbs were also weaker than the healthy limbs (2.46 ± 0.91 N.m/kg vs 2.79 ± 0.96 N.m/kg, p = 0.0008) which represents a difference of 13% between healthy and pathological limbs. For the hamstrings of the pathological limbs, we observed a maximum peak torque at C60 and C240 lower than for the hamstrings of the healthy limbs (1.26 ± 0.37 N.m/kg vs. 1.37 ± 0.36 N.m/kg, p = 0.006 and 0.80 ± 0.23 N.m/kg vs 0.85 ± 0.20 N.m/kg, p = 0.04). The bilateral differences of hamstring strength were 8.7% in C60 and 6% in C240. The PS were more painful than the HS (VAS C60: 3.47 ± 2.65 vs 0.20 ± 1.05; p>0.01; VAS C240: 2.83 ± 2.47 vs. 0.68 ± 0.10; p>0.01; VAS E30: 5,26 ± 2.78 vs 0.58 ± 1.93; p>0.01). The difference of pain can be seen especially in eccentric mode. This observation suggest that isokinetic tests, beyond the measure of strength, could represent a pain provocation test, even with a possible pronostic value for the efficacy of treatment. Conclusions: In our study, the isokinetic results of patients with proximal patellar tendinopathy showed a significant difference in strength profile between the HS and the PS as well as VAS associated with each tests. However, the diversity of outcomes recorded in our population suggests that an individualized rehabilitation treatment is probably more relevant than a common protocol for the healing of this tendon pathology. Isokinetic tests can also represent a tool for assessment of treatment planning. Finally, it would seem that isokinetic tests in the eccentric mode on the quadriceps can be a pain assessment tool for the pathological tendon. [less ▲]

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See detailL'enseignement-apprentissage du français dans le qualifiant : regards croisés
Scheepers, Caroline ULiege; Outers, Pierre ULiege; Werner, Anne-Catherine ULiege

Poster (2017, April 29)

La présentation donne à voir les résultats partiels d'une recherche exploratoire qui a consisté à questionner les élèves et les professeurs de l'enseignement secondaire de transition et du qualifiant à ... [more ▼]

La présentation donne à voir les résultats partiels d'une recherche exploratoire qui a consisté à questionner les élèves et les professeurs de l'enseignement secondaire de transition et du qualifiant à propos de leurs représentations relatives à l'enseignement-apprentissage du français dans le qualifiant. Pour l'heure, nous disposons des réponses apportées par 30 enseignants et par 450 élèves. A terme, cinquante enseignants et 1000 élèves sont concernés. [less ▲]

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See detailAmbulatory System for Gait Analysis
Boutaayamou, Mohamed ULiege; Bruls, Olivier ULiege; Croisier, Jean-Louis ULiege et al

Conference (2017, April 29)

We describe the principle and use of a wireless, 3-axis accelerometer-based ambulatory system that records acceleration signals and automatically analyses them to characterize normal and pathological gait ... [more ▼]

We describe the principle and use of a wireless, 3-axis accelerometer-based ambulatory system that records acceleration signals and automatically analyses them to characterize normal and pathological gait. The associated algorithm is versatile enough to detect, on a stride-by-stride basis, refined gait parameters that quantify subtle gait disturbances in, e.g., in Parkinson’s disease in a rater-independent way. The experimental results show the potential of the developed accelerometer-based technique to be used in neurology (e.g., characterization of Parkinsonian gait: slowness, shuffling, short steps, freezing of gait, asymmetries in gait), rehabilitation, geriatrics (ex. monitoring activity parameters in the elderly), orthopedics and sport. [less ▲]

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See detailGrazing-induced BVOC fluxes from a managed grassland
Mozaffar, Ahsan ULiege; Schoon, N.; Bachy, Aurélie ULiege et al

Poster (2017, April 28)

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See detailOccurrence of greenhouse gases (CO2, N2O and CH4) in groundwater of the Walloon Region (Belgium).
Jurado Elices, Anna ULiege; Borges, Alberto ULiege; Pujades, Estanislao ULiege et al

Conference (2017, April 28)

Greenhouse gases (GHGs) are an environmental problem because their concentrations in the atmosphere have continuously risen since the industrial revolution. They can be indirectly transferred to the ... [more ▼]

Greenhouse gases (GHGs) are an environmental problem because their concentrations in the atmosphere have continuously risen since the industrial revolution. They can be indirectly transferred to the atmosphere through groundwater discharge into surface water bodies such as rivers. However, their occurrence is poorly evaluated in groundwater. The aim of this work is to identify the hydrogeological contexts (e.g., chalk and limestone aquifers) and the most conductive conditions for the generation of GHGs in groundwater at a regional scale. To this end, carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) concentrations, major and minor elements and environmental isotopes were monitored in several groundwater bodies of the Walloon Region (Belgium) from September 2014 to June 2016. The concentrations of GHGs in groundwater ranged from 1769 to 100519 ppm for the partial pressure of CO2 and from 0 to 1064 nmol/L and 1 to 37062 nmol/L for CH4 and N2O respectively. Over- all, groundwater was supersaturated in GHGs with respect to atmospheric equilibrium, suggesting that groundwater contribute to the atmospheric GHGs budget. Prior inspection of the data suggested that N2O in groundwater can be produced by denitrification and nitrification. The most suitable conditions for the accumulation of N2O are promoted by intermediate dissolved oxygen concentrations (2.5-3 mg L−1) and the availability of nitrate (NO3 ). These observations will be compared with the isotopes of NO3 . CH4 was less detected and at lower concentration than N2O, suggesting that groundwater redox conditions are not reducing enough to promoted the production of CH4. The results will be presented and discussed in detail in the presentation. [less ▲]

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See detailStreamlining NCA independence in reforming Regulation 1/2003: time to take incongruent accountability realities (more) seriously?
Van Cleynenbreugel, Pieter ULiege

Conference (2017, April 28)

This presentation analyses argues that the Commission’s reform suggestions aimed at streamlining NCAs into independent administrative agencies appear to neglect this variety of accountability mechanisms ... [more ▼]

This presentation analyses argues that the Commission’s reform suggestions aimed at streamlining NCAs into independent administrative agencies appear to neglect this variety of accountability mechanisms underlying current NCA institutional organisation and functioning. Given that those mechanisms each harbour incongruent expectations regarding the organisation and functioning of independent NCAs, failure to acknowledge such incongruence may in practice lead to less effective competition law enforcement. Its purpose is therefore to uncover the different NCA independence perspectives underlying those accountability mechanisms and to look for legally sound ways to make them converge when designing or upgrading NCA independence in the context of the Regulation 1/2003 reform. [less ▲]

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See detailDeveloping suitable methods for effective characterization of electrical properties of root segments
Ehosioke, Solomon ULiege; Phalempin, Maxime; Garré, Sarah ULiege et al

Conference (2017, April 28)

Developing suitable methods for effective characterization of electrical properties of root segments Solomon Ehosioke (1), Maxime Phalempin (2), Sarah Garré (3), Andreas Kemna (4), Sander Huisman (5 ... [more ▼]

Developing suitable methods for effective characterization of electrical properties of root segments Solomon Ehosioke (1), Maxime Phalempin (2), Sarah Garré (3), Andreas Kemna (4), Sander Huisman (5), Mathieu Javaux (2), and Frédéric Nguyen (1) (1) Department of Architecture, Geology, Environment & Constructions, university of Liege, Liège, Belgium, (2) Earth and Life Institute, Environmental Science, Université catholique de Louvain, Louvain-la-Neuve, Belgium, (3) Biosystems Engineering Department, Gembloux Agro-Bio Tech, University of Liege, Gembloux, Belgium, (4) Department of Geophysics, Steinmann Institute, University of Bonn, Germany, (5) Agrosphere (IBG3), Forschungszentrum Ju¨lich GmbH, Ju¨lich, Germany The root system represents the hidden half of the plant which plays a key role in food production and therefore needs to be well understood. Root system characterization has been a great challenge because the roots are buried in the soil. This coupled with the subsurface heterogeneity and the transient nature of the biogeochemical processes that occur in the root zone makes it difficult to access and monitor the root system over time. The traditional method of point sampling (root excavation, monoliths, minirhizotron etc.) for root investigation does not account for the transient nature and spatial variability of the root zone, and it often disturbs the natural system under investigation. The quest to overcome these challenges has led to an increase in the application of geophysical methods. Recent studies have shown a correlation between bulk electrical resistivity and root mass density, but an understanding of the contribution of the individual segments of the root system to that bulk signal is still missing. This study is an attempt to understand the electrical properties of roots at the segment scale (1-5cm) for more effective characterization of electrical signal of the full root architecture. The target plants were grown in three different media (pot soil, hydroponics and a mixture of sand, perlite and vermiculite). Resistance measurements were carried out on a single segment of each study plant using a voltmeter while the diameter was measured using a digital calliper. The axial resistance was calculated using the measured resistance and the geometric parameters. This procedure was repeated for each plant replica over a period of 75 days which enabled us to study the effects of age, growth media, diameter and length on the electrical response of the root segments of the selected plants. The growth medium was found to have a significant effect on the root electrical response, while the effect of root diameter on their electrical response was found to vary among the plants. More work is still required to further validate these results and also to develop better systems to study the electrical behaviour of root segments. Findings from our review entitled “an overview of the geophysical approach to root investigation”, suggest that SIP and EIT geophysical methods could be very useful for root investigations, thus more work is in progress to develop these systems for assessing the root electrical response at various scales. [less ▲]

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See detailN2O eddy covariance fluxes : from field measurements to flux analysis
Lognoul, Margaux ULiege; Debacq, Alain ULiege; Heinesch, Bernard ULiege et al

Poster (2017, April 28)

N2O eddy covariance data were collected for a complete season of sugar beet crop (from first fertilization to harvest). Data treatment and preliminary results are presented.

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See detailImplémentation du programme Lidcombe dans la prise en charge du bégaiement en clinique francophone
Leclercq, Anne-Lise ULiege

Conference (2017, April 28)

This talk presents preliminary results of the Lidcombe program on French stuttering preschool children. The purpose is to discuss its effectiveness in regular clinical context, and with various profiles ... [more ▼]

This talk presents preliminary results of the Lidcombe program on French stuttering preschool children. The purpose is to discuss its effectiveness in regular clinical context, and with various profiles of children. [less ▲]

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See detailAgroforestry in temperate regions: where does the water go?   A case study with ERT in a corn field bordered by poplar trees.
MALOTEAU, Sophie ULiege; Coussement, Tom; Pardon, Paul et al

Conference (2017, April 28)

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See detailPosterior approach in total hip arthroplasty
KURTH, William ULiege

Conference (2017, April 28)

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See detailThe role of coordinators in the internment public policy translation
Darcis, Coralie ULiege

Conference (2017, April 28)

With this presentation, we would like to focus on the particular role of “coordinators” within a context of policy implementation process (Multiannual plans and Masterplan). We will show that the TSI ... [more ▼]

With this presentation, we would like to focus on the particular role of “coordinators” within a context of policy implementation process (Multiannual plans and Masterplan). We will show that the TSI Coordinators endorsed a role of “Translators” [Latour and Callon] since they are at the heart of this implementation process. We therefore argue that those Health Coordinators circulate knowledge between policy-makers and field professionals, between justice and health professionals and between other health coordinators and themselves. This circulation of knowledge can be observed in meetings organised at both the local and federal levels, as well as through more informal meetings and participation in working groups. Coordinators are also inscribing knowledge by writing documents, mails and minutes of meetings. Finally, we would like to argue that this circulation and inscription of knowledge allow the policy implementation process by reinforcing the articulation [Strauss] both between local and policy levels and between justice and health sectors. [less ▲]

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See detailAmok. Au-delà du diagnostic: les perdants radicaux de H.M. Enzensberger
Hamers, Jérémy ULiege; Cormann, Grégory ULiege

Conference (2017, April 28)

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See detailThe Prediction-Focused Approach: An opportunity for hydrogeophysical data integration and interpretation
Hermans, Thomas ULiege; Nguyen, Frédéric ULiege; Klepikova, Maria et al

Conference (2017, April 28)

Hydrogeophysics is an interdisciplinary field of sciences aiming at a better understanding of subsurface hydrological processes. If geophysical surveys have been successfully used to qualitatively ... [more ▼]

Hydrogeophysics is an interdisciplinary field of sciences aiming at a better understanding of subsurface hydrological processes. If geophysical surveys have been successfully used to qualitatively characterize the subsurface, two important challenges remain for a better quantification of hydrological processes: (1) the inversion of geophysical data and (2) their integration in hydrological subsurface models. The classical inversion approach using regularization suffers from spatially and temporally varying resolution and yields geologically unrealistic solutions without uncertainty quantification, making their utilization for hydrogeological calibration less consistent. More advanced techniques such as coupled inversion allow for a direct use of geophysical data for conditioning groundwater and solute transport model calibration. However, the technique is difficult to apply in complex cases and remains computationally demanding to estimate uncertainty. In a recent study, we investigate a prediction-focused approach (PFA) to directly estimate subsurface physical properties from geophysical data, circumventing the need for classic inversions. In PFA, we seek a direct relationship between the data and the subsurface variables we want to predict (the forecast). This relationship is obtained through a prior set of subsurface models for which both data and forecast are computed. A direct relationship can often be derived through dimension reduction techniques. PFA offers a framework for both hydrogeophysical “inversion” and hydrogeophysical data integration. For hydrogeophysical “inversion”, the considered forecast variable is the subsurface variable, such as the salinity. An ensemble of possible solutions is generated, allowing uncertainty quantification. For hydrogeophysical data integration, the forecast variable becomes the prediction we want to make with our subsurface models, such as the concentration of contaminant in a drinking water production well. Geophysical and hydrological data are combined to derive a direct relationship between data and forecast. We illustrate the process for the design of an aquifer thermal energy storage (ATES) system. An ATES system can theoretically recover in winter the heat stored in the aquifer during summer. In practice, the energy efficiency is often lower than expected due to spatial heterogeneity of hydraulic properties combined to a non-favorable hydrogeological gradient. A proper design of ATES systems should consider the uncertainty of the prediction related to those parameters. With a global sensitivity analysis, we identify sensitive parameters for heat storage prediction and validate the use of a short term heat tracing experiment monitored with geophysics to generate informative data. First, we illustrate how PFA can be used to successfully derive the distribution of temperature in the aquifer from ERT during the heat tracing experiment. Then, we successfully integrate the geophysical data to predict medium-term heat storage in the aquifer using PFA. The result is a full quantification of the posterior distribution of the prediction conditioned to observed data in a relatively limited time budget. [less ▲]

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See detailMotion analysis: a prevention tool
Schwartz, Cédric ULiege; CROISIER, Jean-Louis ULiege; Forthomme, Bénédicte ULiege et al

Conference (2017, April 28)

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See detailReligieuses et religieux-architectes, concepteurs et bâtisseurs des monastères féminins à l’époque moderne
Piront, Julie ULiege

Conference (2017, April 28)

Depuis une vingtaine d’années, les études architecturales des monastères féminins implantés en milieu urbain à l’époque moderne se multiplient. Outre l’analyse des vestiges, ces études reposent sur ... [more ▼]

Depuis une vingtaine d’années, les études architecturales des monastères féminins implantés en milieu urbain à l’époque moderne se multiplient. Outre l’analyse des vestiges, ces études reposent sur l’exploitation de sources restées souvent inédites. La (re)découverte de chroniques, d’annales, de lettres circulaires, de récits de fondation et de biographies de religieuses a permis notamment de sortir de l’oubli les noms d’architectes et de maîtres d’œuvres qui ont édifié les monastères féminins dans l’Europe catholique du XVIe au XVIIIe siècle. Si les professionnels laïcs sont souvent mentionnés, il s’avère que des religieux, mais aussi des religieuses ont contribué de manière non négligeable à la construction des monastères féminins en dessinant des plans, supervisant les chantiers et parfois même, en démolissant des édifices ou en transportant des matériaux. Cette communication débute par un état de la question et par un point méthodologique sur les sources de l’étude de ces hommes et de ces femmes architectes. Puisant dans les archives de quelques ordres féminins apparus dans le contexte de la Réforme catholique (visitandines, ursulines, annonciades célestes, bénédictines de la Paix Notre-Dame), il s’agit de mettre en exergue les différents rôles qu’ont occupé les religieuses et les religieux dans l’édification des monastères féminins aux XVIIe et XVIIIe siècles, en s’interrogeant sur leurs formations, leurs compétences et sur les rapports qu’elles et ils ont entretenu avec les commanditaires. [less ▲]

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See detailPathological hip fractures
KURTH, William ULiege

Conference (2017, April 28)

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See detailLe marché du livre à Bruxelles au XVIe siècle
Adam, Renaud ULiege

Conference (2017, April 28)

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See detailGlobally significant greenhouse-gas emissions from African inland waters
Borges, Alberto ULiege; Bouilon, S

Conference (2017, April 28)

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Peer Reviewed
See detailThree-dimensional modelling of the hydrodynamics of the Southern Bight of the North Sea: first results
Ivanov, Evgeny ULiege; Capet, Arthur ULiege; Barth, Alexander ULiege et al

Poster (2017, April 28)

In the frame of the Belgian research project FaCE-It (Functional biodiversity in a Changing sedimentary Environment: Implications for biogeochemistry and food webs in a managerial setting), the impact of ... [more ▼]

In the frame of the Belgian research project FaCE-It (Functional biodiversity in a Changing sedimentary Environment: Implications for biogeochemistry and food webs in a managerial setting), the impact of dredging activities andoffshorewindfarminstallationonthespatialdistributionofsedimentgrainsize,biodiversityandbiogeochemistry will be estimated in the Southern Bight of the North Sea (SBNS) with a focus on the Belgian Coastal Zone (BCZ). To reach this goal, the three-dimensional hydrodynamical model ROMS-COAWST is implemented in the SBNS in order to simulate the complex hydrodynamics and sediment transport. Two levels of nesting are used to reach a resolutionof250mintheBCZ.Themodelisforcedattheair-seainterfacebythe6-hourlyECMWFERA-interim atmospheric dataset and at the open boundaries by the coarse resolution model results available from CMEMS (Copernicus Marine Environment Monitoring Service), and also considers tides and 4 main rivers (Scheldt, Rhine with Maas, Thames and Seine). Two types of simulations have been performed: a 10-years climatological simulation and a simulation over 20032013toinvestigatetheinterannualdynamics.Themodelskillsareevaluatedbycomparingitsoutputstohistorical data (e.g. salinity, temperature and currents) from remote sensing and in-situ. The sediment transport module will then be implemented and its outputs compared to historical and newly collected (in the frame of FaCE-iT) observations on grain size distribution as well as with satellite Suspended Particulate Matter (SPM) images. This will allow assessing the impact of substrate modification due to offshore human activities at local and regional scales. [less ▲]

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See detailA landslide susceptibility map of Africa
Broeckx, Jente; Vanmaercke, Matthias ULiege; Duchateau, Rica et al

Conference (2017, April 28)

Studies on landslide risks and fatalities indicate that landslides are a global threat to humans, infrastructure and the environment, certainly in Africa. Nonetheless our understanding of the spatial ... [more ▼]

Studies on landslide risks and fatalities indicate that landslides are a global threat to humans, infrastructure and the environment, certainly in Africa. Nonetheless our understanding of the spatial patterns of landslides and rockfalls on this continent is very limited. Also in global landslide susceptibility maps, Africa is mostly underrepresented in the inventories used to construct these maps. As a result, predicted landslide susceptibilities remain subject to very large uncertainties. This research aims to produce a first continent-wide landslide susceptibility map for Africa, calibrated with a well-distributed landslide dataset. As a first step, we compiled all available landslide inventories for Africa. This data was supplemented by additional landslide mapping with Google Earth in underrepresented regions. This way, we compiled 60 landslide inventories from the literature (ca. 11000 landslides) and an additional 6500 landslides through mapping in Google Earth (including 1500 rockfalls). Various environmental variables such as slope, lithology, soil characteristics, land use, precipitation and seismic activity, were investigated for their significance in explaining the observed spatial patterns of landslides. To account for potential mapping biases in our dataset, we used Monte Carlo simulations that selected different subsets of mapped landslides, tested the significance of the considered environmental variables and evaluated the performance of the fitted multiple logistic regression model against another subset of mapped landslides. Based on these analyses, we constructed two landslide susceptibility maps for Africa: one for all landslide types and one excluding rockfalls. In both maps, topography, lithology and seismic activity were the most significant variables. The latter factor may be surprising, given the overall limited degree of seismicity in Africa. However, its significance indicates that frequent seismic events may serve as in important preparatory factor for landslides. This finding concurs with several other recent studies. Rainfall explains a significant, but limited part of the observed landslide pattern and becomes insignificant when also rockfalls are considered. This may be explained by the fact that a significant fraction of the mapped rockfalls occurred in the Sahara desert. Overall, both maps perform well in predicting intra-continental patterns of mass movements in Africa and explain about 80% of the observed variance in landslide occurrence. As a result, these maps may be a valuable tool for planning and risk reduction strategies. [less ▲]

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See detailLa place des genres textuels dans la perspective actionnelle des langues étrangères
Simons, Germain ULiege; Delbrassine, Daniel ULiege

Poster (2017, April 28)

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See detailNutritional and organoleptic quality of Beni-Guil lamb meat breeding in eastern Morocco
Belhaj, Kamal ULiege; Mansouri, Farid; Sindic, Marianne ULiege et al

Poster (2017, April 27)

Nowadays in Morocco, 98% of red meat production is ensured by cattles, sheeps and goast. The eastern Morocco represents one of the main sheep farming areas, characterized by the specificity of its ... [more ▼]

Nowadays in Morocco, 98% of red meat production is ensured by cattles, sheeps and goast. The eastern Morocco represents one of the main sheep farming areas, characterized by the specificity of its production systems. So it is well known by the quality of the sheep meat produced. The Beni-Guil breed is a dominate breed in this breeding area, labeled Protected Geographical Indication (PIG). Thus, it’s an important protein source for the population in this geographical site and highly appreciated by consumers. This reputation is limited to the hedonic quality, and there is currently no scientific data available on the organoleptic and nutritional quality of Beni-Guil meat. The objective of this research is to give a scientific point on the nutritional and organoleptic quality of this meat by biochemical analyzes of the major and minor composition of the Longissimus dorsi muscle (LDM). The results of the organoleptic quality analysis show that the meat of Beni-Guil breed has a bright red color, with a chromaticity of 23.97, an a/b ratio of 0.96 and a hue angle of 46.47, Significant juiciness with a water retention capacity and cooking loss of 22.73 and 32.87% respectively, and a marked tenderness with a collagen content of 0.1%. Thus the analysis of nutritional quality showed that LDM of the Beni-Guil has a high nutritional and dietary value, rich in polyunsaturated fatty acid (PUFA) and essential amino acid, with an PUFA/SFA ratio of 0.25, a ratio PUFA n-6/PUFA n-3 of 3.78, and a Protein Digestibility-Corrected Amino Acid score (PDCAAS) of 127. [less ▲]

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See detailDoes tree species richness attenuate the effect of experimental irrigation and drought on decomposition rate in young plantation forests?
Rahman, Md Masudur ULiege; Verheyen, Kris; Castagneyrol, Bastien et al

Poster (2017, April 27)

Expected changes in precipitation in Europe due to climate change are likely to affect soil organic matter (OM) transformation. In forests, increasing tree species diversity might modulate the effect of ... [more ▼]

Expected changes in precipitation in Europe due to climate change are likely to affect soil organic matter (OM) transformation. In forests, increasing tree species diversity might modulate the effect of changed precipitation. We evaluated the effect of tree species richness on the decomposition and stabilization rate in combination with reduced precipitation (FORBIO, Belgium) and irrigation treatment (ORPHEE, southern France) in young (6-8 yr.) experimental plantations. The species richness were one to four in FORBIO and one to five in ORPHEE. Twenty four rainout shelters of 3 m × 3 m were built around oak and beech trees in FORBIO plantation to impose a reduced precipitation treatment, whereas four of the eight blocks (175 m×100 m) in ORPHEE plantation was subjected to irrigation treatment. These treatments resulted in about 4% less soil moisture in FORBIO and about 7% higher soil moisture in ORPHEE compared to control. Commercially available green and rooibos tea bags were buried in the soil at 5-7 cm depth to measure two decomposition indices, known as ‘tea bag index’ (TBI). These TBI are (i) decomposition rate (k) and (ii) stabilization rate (S). The results showed no species richness effect on TBI indices in both reduced precipitation and irrigation treatment. In FORBIO, reduced precipitation resulted in decreased k and increased S compared to control around the beech trees only. In ORPHEE, both k and S were higher in the irrigation treatment compared to control. Overall, TBI indices were higher in FORBIO than ORPHEE and this might be explained by the sandy soils and poor nutrient content at the ORPHEE site. These results suggest that OM decomposition rate may be slower in drier condition and OM stabilization rate may be slower or faster in drier condition, depending on the site quality. The absence of tree species effects on OM transformation indicates that tree species richness would not be able to modulate the effects of changed precipitation patterns in young plantations. We conclude that in young afforestations, soil moisture has more influence on OM transformation than tree species richness. [less ▲]

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See detailTowards standardisation of practitioners' knowledge: the case of private intermediaries of the labour market
Gérard, Julie ULiege

Conference (2017, April 27)

This contribution analyses the stakes of activation policies in the French-speaking part of Belgium. It focuses on the private intermediaries of the labour market in "public-private partnership" with ... [more ▼]

This contribution analyses the stakes of activation policies in the French-speaking part of Belgium. It focuses on the private intermediaries of the labour market in "public-private partnership" with Belgian public employment services. It examines intermediaries‘work in devising and implementing employment policies and more precisely a particular activation measure called the job seeker’s support. This measure intends to improve job seekers’ socio-professional reinsertion by reducing exclusion and encouraging the return to employment. The sociological analysis of this activation measure relies on in-depth analyses of four categories of private intermediaries mandated by Belgian public employment services to support job seekers towards employment. The analyses are based on a qualitative and empirical research combining direct observations (N=254), semi-structured interviews and documentary analyses (N=29). Theoretically, they rely on the sociology of public action. This contribution demonstrates that, despite organisational contingencies and the discretionary power of the involved actors in implementing employment policies, the work of the private intermediaries of the labour market participates in increasing the standardisation of public action. This standardisation represents the transformation of knowledge that is enacted through interaction between job seekers’ and practitioners, private intermediaries of the labour market. This one inscribes and standardises knowledge into norms, figures and instruments (such as reporting, dashboards). This process, from enacted to inscribed knowledge, embodies institutional pressures in supporting job seekers and relies on new modes of delivery and implementation employment policies. [less ▲]

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See detailLorrAgri: methodology and experience of a territorial transition lab
Feyereisen, Marlène ULiege

Conference (2017, April 27)

Many scholars have underlined the potential of spatialized (or territorialized) approaches to analyse and guide the transition of the agrifood system. For example, scale reductions often associated with ... [more ▼]

Many scholars have underlined the potential of spatialized (or territorialized) approaches to analyse and guide the transition of the agrifood system. For example, scale reductions often associated with territorialisation offers the opportunity to modify power relations between actors and permits to improve their ability to act – or empower. While territorialized approaches to transition management are promising, to date only few studies have considered these aspects in unison. This study presents the methodology used to design and guide a transition management experience. We describe the tools used, issues raised, and potential benefits of the experience for transition, as well as challenges and limitations. Furthermore, we investigate how tools from transition theories were able to support the experience (multi-level perspective, transition management and strategic niche management). LorrAgri is a “territorial transition lab” organised from early 2016 until present day, and aims to develop the local agrifood system (in particular vegetables) in the rural area of Belgian Lorraine in the South of Belgium. This area has relatively well-developed non-conventional agriculture compared to the rest of Belgium, and recently developed market gardening. The present work is based on extensive data selection, including semi-structured interviews and participant observations. Strategic analysis sociology was used to identify possible strategies and challenges between actors of the agrifood system in the selected territory. From these diagnostics of the territory and its actors, the LorrAgri group was created in January 2016, initially with market gardeners. Over time, organisations joined also (both from the regime and niches) which work on local agrifood development, culminating today in the active support and involvement of local politics. Analyses were conducted at several of these stages, and fed by inputs from transition theories. Our study shows that the territorialized approach can enable cooperation between actors which oppose each other, in terms of norms and values. Therefore, LorrAgri is an interesting case study to analyse modes of cooperation between actors e.g. from the regime and the niches, and how norms and values from different levels can influence each other (transition in-the-making). This study also details how participants found a common objective for developing the local agrifood system, namely to supply local products to collective catering, e.g. school canteens and restaurants. [less ▲]

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See detailMeeting Fronstage, Deciding Backstage
Slomian, Cynthia ULiege

Conference (2017, April 27)

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See detail“New Ways of Working” and their managerial myths: the resurgence of liberation and distributed surveillance?
Jemine, Grégory ULiege

Conference (2017, April 27)

Through this contribution we aim to explore how two well-known bodies of knowledge, namely the panopticism as developed by Foucault (2012) and the works from the Human Relations movement (Mayo, 1949) are ... [more ▼]

Through this contribution we aim to explore how two well-known bodies of knowledge, namely the panopticism as developed by Foucault (2012) and the works from the Human Relations movement (Mayo, 1949) are being reprocessed and reinjected by managerial actors in organisational projects of “modernisation” such as “New Ways of Working”. Nowadays, in open and flexible workspaces, visual and acoustic privacy at work tend to disappear (Van der Voort, 2004) which leaves room for a constant monitoring of employees’ behaviours, mainly performed by the peers (Sewell & Taskin, 2015). The old managerial myth of distributed surveillance resurfaces as everyone is in a position to monitor his colleagues, generating a global feeling of unease. Simultaneously several managerial discourses advocate for abolishing direct supervision and liberating the employees of the bureaucratic factors through self-managed teams and empowerment. The defenders of “freedom” in companies build their argumentation on former findings from the Human Relations movement such as the improved efficiency of small groups and the benefits of removing rules. In an historical perspective, we wonder why and how such elements of knowledge produced several decades ago now become performative in several Belgian companies. [less ▲]

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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

Poster (2017, April 27)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

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See detailSedimentation influx and volcanic interactions in the Fuji Five Lakes: implications for paleoseismological records
Lamair, Laura ULiege; Hubert, Aurelia ULiege; Yamamoto, Shinya et al

Conference (2017, April 27)

The Fuji Fives Lakes are located at the foot of Mount Fuji volcano close to the triple junction, where the North American Plate, the Eurasian plate and the Philippine Sea Plate meet. These lakes are ... [more ▼]

The Fuji Fives Lakes are located at the foot of Mount Fuji volcano close to the triple junction, where the North American Plate, the Eurasian plate and the Philippine Sea Plate meet. These lakes are ideally situated to study Mount Fuji volcanism and the interaction between volcanism, changes in lake sedimentation rates and the ability of lakes to record paleoearthquakes. Here, we present newly acquired geological data of Lake Yamanaka and Lake Motosu, including seismic reflection profiles, gravity and piston cores. These two lakes and their respective watersheds were affected by several eruptions of Mount Fuji. Lake Yamanaka, a very shallow lake (max. depth 14 m), was heavily impacted by the scoria fall-out of the A.D. 1707 Hoei eruption of Mount Fuji. A detailed investigation of the effect of the Hoei eruption was conducted on short gravity cores, using high resolution XRD, C/N and 210Pb/137Cs analyses. The preliminary results suggest that the sedimentation rate of Lake Yamanaka drastically reduced after the Hoei eruption, followed by an increase until the present day. Similarly, lacustrine sedimentation in Lake Motosu (max. depth 122 m) was disturbed by Mount Fuji volcanism at a larger scale. The watershed of Lake Motosu was impacted by several lava flows and scoria cones. For example, the Omuro scoria cone reduced the catchment size of Lake Motosu and modified its physiography. The related scoria fall out covered an extensive part of the lake catchment and reduced terrigenous sedimentary influx to Lake Motosu. Within the deep basin of Lake Motosu, seismic reflection data shows two different periods that are distinguished by a major change in the dominant sedimentary processes. During the first period, sublacustrine landslides and turbidity currents were the dominant sedimentation processes. During the second one, the seismic stratigraphy evidences only deposition of numerous turbidites interrupting the hemipelagic sedimentation. Changes in sedimentary processes can be linked to the modification of the lake watershed by Mount Fuji volcanism, leading to a decrease in the sediment volume that can be remobilized, and therefore disappearance of large sublacustrine landslides. Turbidites are deposited due to surficial remobilization of lake slope sediments most probably as a result of earthquake shaking. When studying sedimentological records of lakes to define the paleoearthquake record, eruptions of nearby volcanoes should be taken into account. This study suggests that a large magnitude earthquake occurring few decades after a volcanic eruption (with large scale scoria fall-out), might not be recorded in a lake, or would only be fingerprinted in the sedimentary record by small turbiditic flows. References: Miyaji N., Kan'no A., Kanamaru T., Mannen K. 2011. High-resolution reconstruction of the Hoei eruption (AD 1707) of Fuji volcano, Japan. Journal of Volcanology and Geothermal Research 207, 113–129. [less ▲]

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See detailCARACTERISATION BIOCHIMIQUE DES AMANDES DE QUELQUES VARIETES D’AMANDIER EN CULTURE DANS LA REGION ORIENTALE DU MAROC
Melhaoui, Reda; Houmy, Nadia ULiege; Ben Moumen, A et al

Poster (2017, April 27)

Le Plan Maroc Vert (PMV) accorde une grande importance à l’agriculture solidaire en faveur des zones agro écologiques fragiles. Dans ce cadre on assiste dans la région orientale du Maroc à l’extension des ... [more ▼]

Le Plan Maroc Vert (PMV) accorde une grande importance à l’agriculture solidaire en faveur des zones agro écologiques fragiles. Dans ce cadre on assiste dans la région orientale du Maroc à l’extension des plantations d’amandier, au dépend des cultures annuelles, jugées non rentable et étroitement lié à la pluviométrie. Ainsi le projet*PROFAO porte sur la plantation de 6000 ha de nouveaux vergers d’amandier, avec principalement les variétés Ferragnes et Ferraduel (F/F) en raison de leur floraison tardive en Mars, qui leur permet d’échapper aux effets néfastes des gelées de Janvier et Février. Dans un but de la diversité des cultures et de la sauvegarde de la biodiversité et également dans un but de valorisation en post récolte des amandes et produits dérivés. Cette étude porte sur la caractérisation de variété(s) locale(s), nommée «Amandier Beldi (Be)» à floraison précoce et qui semble être une variété population. La comparaison aux variétés F/F, porte sur des caractères botaniques et la période de floraison et surtout sur la composition chimique des amandes comme produits final de la récolte. A ce propos «Be» fleurissent dès le début février alors que pour F/F la floraison est pour Mars. Les analyses des huiles et tourteaux d’amandes des récoltes antécédentes, montent un rendement moyen en huile, de l’ordre de 50% pour «Be» et de 57% pour «F/F» avec des profils d’acide gras comparables. L’analyse des tourteaux ne montre pas de différences significatives ainsi on observe, pour« Be » des teneurs en protéines de 47% et en sucres de 14,2% et pour l’association F/F ces teneurs sont respectivement de 45% et 13% [less ▲]

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See detailHighlights from two years of remote sensing at Mars with MAVEN’s Imaging Ultraviolet Spectrograph
Chaffin; Schneider; Deighan et al

Poster (2017, April 27)

The Mars Atmosphere and Volatile EvolutioN (MAVEN) mission’s Imaging Ultraviolet Spectrograph (IUVS) observes Mars in the far and mid ultraviolet (110-340 nm), investigating lower and upper atmospheric ... [more ▼]

The Mars Atmosphere and Volatile EvolutioN (MAVEN) mission’s Imaging Ultraviolet Spectrograph (IUVS) observes Mars in the far and mid ultraviolet (110-340 nm), investigating lower and upper atmospheric structure and indirectly probing neutral atmospheric escape. After two Earth years in orbit (one Mars year), IUVS has assembled a large quantity of data and made many discoveries, some of which we report here. Among the key results obtained by IUVS are: (1) discovery of the widespread occurrence of a diffuse proton aurora, representing a newly discovered means of energy deposition into the atmospheres of unmagnetized planets; (2) continued investigation of time-variability in H and O escape, which have dessicated the planet over its history; and (3) synoptic characterization of thermospheric variability and response to solar input. We will present an overview of these results and a discussion of their implications for the state of the atmosphere and its evolution. [less ▲]

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See detailWater chemical evolution in Underground Pumped Storage Hydropower plants and induced consequences.
Pujades, Estanislao ULiege; Orban, Philippe ULiege; Jurado Elices, Anna ULiege et al

Conference (2017, April 27)

Underground Pumped Storage Hydropower (UPSH) using abandoned mines is an alternative to manage the elec- tricity production in flat regions. UPSH plants consist of two reservoirs; the upper reservoir is ... [more ▼]

Underground Pumped Storage Hydropower (UPSH) using abandoned mines is an alternative to manage the elec- tricity production in flat regions. UPSH plants consist of two reservoirs; the upper reservoir is located at the surface or at shallow depth, while the lower reservoir is underground. These plants have potentially less constraints that the classical Pumped Storage Hydropower plants because more sites are available and impacts on landscape, land use, environment and society seem lower. Still, it is needed to consider the consequences of the groundwater exchanges occurring between the underground reservoir and surrounding porous media. Previous studies have been focused on the influence of these groundwater exchanges on the efficiency and on groundwater flow impacts. However, hydrochemical variations induced by the surface exposure of pumped water and their consequences have not been yet addressed. The objective of this work is to evaluate the hydrochemical evolution of the water in UPSH plants and its effects on the environment and on the UPSH efficiency. The problem is studied numerically by means of reactive transport modelling. Different scenarios are considered varying the chemical properties of the surrounding porous medium and groundwater. Results show that the dissolution and/or precipitation of some compounds may affect (1) the groundwater quality, and (2) the efficiency and the useful life of the used pumps and turbines of the UPSH system. [less ▲]

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See detailHybrid places : a conceptual framework
Uyttebrouck, Constance ULiege; Teller, Jacques ULiege

Poster (2017, April 27)

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Peer Reviewed
See detailUne ou deux institutions méconnaissables ?
Glorie, Caroline ULiege

Conference (2017, April 27)

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See detailImportin-8 could cause CAE/JME by delaying early neuroblast migration
Nganou, Gerry ULiege; Tanaka, Miyabi; Coumans, Bernard ULiege et al

Poster (2017, April 27)

Abstract : Childhood Absence Evolving to Juvenile Myoclonic Epilepsy (CAE/JME) is an uncommon form of genetic generalized epilepsy that appears as absence in childhood and evolves into generalized ... [more ▼]

Abstract : Childhood Absence Evolving to Juvenile Myoclonic Epilepsy (CAE/JME) is an uncommon form of genetic generalized epilepsy that appears as absence in childhood and evolves into generalized tonic–clonic seizures with myoclonic jerks during adolescence. In some family of patients affected by CAE/JME, mutations have been observed in the gene encoding for the transport protein importin-8 (IPO8). IPO8 could be at the origin of CAE/JME via its role in the transport of its targets (like Ago-2, Smad4, c-Jun). RT-qPCR has shown that IPO8 mRNA is expressed at all ages with no big difference in expression level. Using ISH, a clear expression of mIPO8 mRNA was observed in the sub-ventricular/ventricular zone (SVZ/VZ), the cortical plate (CP) and the ganglionic eminences (GE) of developing brain at E14. Both SVZ/VZ and GE are the “neurogenic niches” that generate glutamatergic and GABAergic neurons respectively. The implication of IPO8 in the generation of “glutamatergic neurons” was investigated by In Utero electroporation (IUE) and MGE Electroporation. Using shRNA, we observed that after 3 days, “glutamatergic neuroblasts” do not reach the CP in contrast to the control condition. This effect can be rescued by the co-expression of a form of IPO8 that is resistant to the shRNA. When overexpressing the pathological forms of hIPO8, but not a variant, migration of “glutamatergic neuroblasts” was also impaired. However, when the observation is made later, i.e. at P5, we observed that the neuroblasts finally reach their correct layer in the cortex, suggesting IPO8 only delayed but not blocked migration. Moreover, shRNA against IPO8 mRNA lead to alteration of interneurons (GABAergic neurons) migration same to overexpression of one mutated form of IPO8. Conclusion : IPO8 is expressed in mouse brain during development. It shows a clear expression during embryogenesis in the “neurogenic niches”. Moreover, IPO8 modulates neuroblasts (radial and tangential) migration in the developing brain. So, abnormal brain development due to IPO8 mutations could be at the origin of CAE/JME. [less ▲]

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See detailA Belgian reform towards an integrated care system for chronic patients: the ubiquity of knowledge
De Winter, Mélanie ULiege

Conference (2017, April 27)

Countries all over Europe are currently facing budgetary pressures regarding their health care systems due to scientific progress, population ageing and a sharp rise in chronic diseases. In the European ... [more ▼]

Countries all over Europe are currently facing budgetary pressures regarding their health care systems due to scientific progress, population ageing and a sharp rise in chronic diseases. In the European Union, chronic diseases are now the leading cause of death and the most important item of health expenditures (Schokkaert &Van de Voorde, 2011). In 2015, the Belgian Health Ministers launched a joint public health plan called “Integrated Care for Better Health” (2015) to bring about a transition from an institutional system to an integrated care system for patients with chronic diseases. The authorities are nevertheless uncertain of the solutions to adopt in the Belgian context. Consequently, they have chosen to turn this plan into practice through 4-year pilot projects as part of an iterative and incremental implementation strategy. These iterative and incremental aspects entail a constant production and circulation of knowledge by and between actors involved in the co-construction process, between policy-makers and field actors responsible for policy implementation. As a result, this presentation focuses on concrete practices (preparatory meetings, plenary sessions, recourse to websites and forums, writing documents, etc.) that enact and stabilize knowledge that is produced, transformed and circulated between the different actors of the care production chain. These practices will be identified thanks to the methodological triangulation approach (policy documentary analysis, direct observation, semi-structured interviews). [less ▲]

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See detailProfil d'acides gras et acides aminés essentiels de la vainde ovine de la race Beni-Guil conduite en élevage semi-extensif dans l'est du Maroc
Belhaj, Kamal ULiege; Mansouri, Farid; Sindic, Marianne ULiege et al

Poster (2017, April 27)

Les viandes sont commercialisées sous forme de muscles prêts à découper ou de portions « pièces »prêtes à cuire. La couleur de la viande est le premier paramètre de qualité perçue par le consommateur ... [more ▼]

Les viandes sont commercialisées sous forme de muscles prêts à découper ou de portions « pièces »prêtes à cuire. La couleur de la viande est le premier paramètre de qualité perçue par le consommateur, ensuite les paramètres de qualité organoleptiques, hygiénique et nutritionnelle deviennent déterminants et le guide dans son choix. La viande ovine de la race Béni-Guil, qui bénéficie de l’Indication géographique protégée est réputée pour sa qualité gustative et nutritionnelle mais uniquement sur la base de tests hédonique. De ce fait, vient cette étude sur l’analyse de la couleur et des profils lipidiques et protéiques du muscle long dorsal (LDM), un muscle de référence et morceau de viande apprécié par le consommateur. L’analyse de la couleur a montré que LDM de la race béni-guil a une couleur rouge vif très recherché par le consommateur avec un indice de rouge de 14,74. Les résultats d’analyse par GC-FID a permis l’identification de 27 d’acide gras (AG). Comme il a été signalé dans d’autres études (1,2). On observe, qu’un apport de suppléments alimentaires à base d’orge et de son en période critique (sécheresse, ou période de soudure), engendrerait des variations assez importantes par rapport à une conduite au pâturage. En effet, au niveau du profil lipidique le taux d’AG saturés augmente de 40% à 49% au dépend du taux d’AG insaturés qui chute de 60 à 51%. Pour les AG majoritaires, les plus importantes variations ont été enregistrées pour la teneur en acide oléique (C18:1n9) qui chute de 38% à 35%, en faveur de l’acide palmitique (C16:0) qui augmente de 20 à 24%. L’analyse de la composition en acides aminés par HPLC a permis l’identification de 17 acides aminés dont 8 essentiels (His, Mét, Ile, Leu, Lys, Thr, Val, Phe). [less ▲]

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See detailBotanical and Physicochemical characterization of almond population varietal in eastern Morocco
Melhaoui, Reda; Houmy, Nadia ULiege; Mihamou, Atika et al

Poster (2017, April 27)

Abstract: Cooperatives play an important role in socio-economic development. In this regard, the Eastern Morocco adopts this strategy via the PROFAO* Project as a way of promoting local development, which ... [more ▼]

Abstract: Cooperatives play an important role in socio-economic development. In this regard, the Eastern Morocco adopts this strategy via the PROFAO* Project as a way of promoting local development, which guarantees sustainable jobs. This project is based on planting 6000 ha of new almond orchards and creating three cooperatives to value post-harvest Almond products. Currently the Eastern Moroccan regions could benefit of the new project PRD** which will include local Almond varieties characterization to safeguard its biodiversity and the valorization of its products. This study concerns two mains points 1) Botanical characterization of local varieties named "almond Beldi (Be)" based on the flowering period and determination of the color of the flowers 2) Physicochemical characterization of some parameters such as the oil yield, acid and peroxide values. This botanical study shows the result of the early flowering variety (Be) (beginning in February). The color results of 100 flowers analyzed by chromametre , shows two different color categories. The first is very light pink to white (L*=81,58 ; a*=7.43 ;b*=8.06) and the second is a dark pink (L*=71,64 ;a*= 18,34 ;b*= 4,97), with a difference in color between the two categories ∆E=15.07. This almond variety shows an oil yield of 50%, a low acidity value 0,039 (% of Linoleic acid ) and a peroxide value of 16.39 (meq/o2/Kg). [less ▲]

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See detailProfil d'acides gras et stabilité oxydative d'huiles de brisures d'amandons et d'écarts de tri des amandes
Houmy, Nadia ULiege; Melhaoui, R; Sindic, Marianne ULiege et al

Conference (2017, April 27)

Dans la région orientale du Maroc, en outre du projet *PROFAO, la filière Amandier bénéficie d'une attention particulière. Cependant, les opérations de concassage et de triage des amandes se font encore ... [more ▼]

Dans la région orientale du Maroc, en outre du projet *PROFAO, la filière Amandier bénéficie d'une attention particulière. Cependant, les opérations de concassage et de triage des amandes se font encore de façon artisanale. Dans un but de valorisation après le décorticage/concassage, les brisures et les écarts de tri des amandes, ayant une faible valeur marchande, servent à l'extraction d'huile pour usage alimentaire et cosmétique. Ce travail porte sur l'analyse chimique d'huiles de brisures d'amandes (HbA) et la détermination de leur stabilité oxydative. Ainsi sur trois compagnes agricoles consécutives 2014, 2015, 2016, des analyses par CPG FID des profils d'acides gras (AG) des HbA des variétés Marcona Ferragnes-Ferraduel, ont été effectuées. L'acide Oléique (C18:1) et l'acide Linoléique (C18:2) sont les deux AG majoritaires qui caractérisent les profils d'AG des HbA. Selon l'année de récolte, ces HbA ont montré des variations inter variétale, les différences observées sont significatives et sont de l'ordre de 15 % pour C18:1 et de 13 % pour C18:2. Ainsi la teneur des HbA analysées en C18:1 varie entre un taux-max de 72 % enregistré en 2013/2014 pour Ferrangnes-Ferraduel et un taux-minima de 57 % observé en 2015/2016 pour Marcona. La même remarque pour le C18:2 avec une teneur minimum de 17 % enregistré en 2013/2014 pour Ferragnes-Ferraduel et une teneur maximum de 30 % observé en 2015/2016 pour Marcona. Pour le rapport O/L la plus grande différence a été observée en 2013/2014, avec un ratio O/L de 4,1 pour l'HbA Ferragnes-Ferraduel et de 1,95 pour Marcona. Les résultats observés pour la stabilité oxydative des Hba estimée par des tests Rancimat montrent des valeurs qui varient entre un minimum de 20h pour l'HbA Marcona en 2013/2014 et un maximum de 29h pour l'HbA Ferragnes Ferraduel en 2015/2016. On note une corrélation positive entre la stabilité oxydative et la teneur des HbA en C18:1 ainsi qu'avec le ratio O/L. La suite logique de ce travail est la recherche d'une correlation entre la stabilité oxydative et les composants mineurs de l'huile notamment ceux à activité antioxydante tel les tocophérols. [less ▲]

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See detailFirst retrievals of methane isotopologue, CH3D, from FTIR ground-based observations
Bader, Whitney ULiege; Strong, Kimberley; Walker, Kaley et al

Poster (2017, April 26)

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See detailInterviews on Residential Building Stock Deep Renovation in Belgium
Ruellan, Guirec ULiege

Poster (2017, April 26)

Belgium should increase the deep renovation rate of existing residential building stock at least to 3% a year to achieve the EU objectives of decreasing by 80% the Green House Gas Emissions before 2050 ... [more ▼]

Belgium should increase the deep renovation rate of existing residential building stock at least to 3% a year to achieve the EU objectives of decreasing by 80% the Green House Gas Emissions before 2050. Since the first thermal legislations (between 1985 and 2000, depending on the Region), efficiency and comfort of newly built houses have met higher standards. But the renovation rate of residential buildings remained stable in the last 20 years. Only 25000 renovation permits are issued each year, in which a small amount of them are highly energy efficient. Literature review has showed that drivers and barriers of deep renovation are many and varied, sometimes contradictory and often underestimated. Conducted interviews with experts who study different facet of renovation present some others viewpoints on this subject. According to their own specific experience, each interviewee thinks differently on possible solutions. The poster set out the interview analysis. Some points are very close to the literature review, such as the environmental and economic issues of the residential renovation, while other results are solely extracted based on the interviews’ results. Amongst others, the necessity to maintain and improve the existing building stock to new standards takes an important place. The regulation appears to be a good driver as much as a barrier, depending on the local legislations and buildings context particularly in Belgium where the diversity of the building stock is very important. Public policies seem to be the first tools to unlock the renovation rate even if the development of new financial model and the information of stakeholders are also highlighted. This analysis increases the comprehension of the renovation topic on a new level, including some adjacent ideas that lead to better understanding of the existing barriers and possible strategies to overtake them, so that to involve everyone in the renovation strategy definition to promote the most efficient one. [less ▲]

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See detailDiabetes and the kidney disease risk
Krzesinski, Jean-Marie ULiege

Conference (2017, April 26)

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See detailPraxis, besoins et impératifs affectifs : Réflexions sur la normativité de la conscience émue.
Recchia, Fabio ULiege

Conference (2017, April 26)

L'objectif de cette communication consiste à dégager les caractéristiques normatives de la conscience émue. Nous mobiliserons pour ce faire la thématique des "impératifs affectifs", qui est abondamment ... [more ▼]

L'objectif de cette communication consiste à dégager les caractéristiques normatives de la conscience émue. Nous mobiliserons pour ce faire la thématique des "impératifs affectifs", qui est abondamment discutée par Sartre dans "Les Racines de l'éthique". Sur cette base, nous développerons une réflexion en trois temps. 1° Nous situerons tout d'abord les "Racines de l'éthique" dans la continuité des réflexions de "l'Esquisse d'une théorie des émotions". 2° Nous montrerons ensuite que l'analyse des impératifs affectifs enveloppe une critique du positivisme, qui est une approche massivement adoptée par nombre de philosophie des émotions. 3° Enfin, nous approfondirons la description sartrienne des impératifs affectifs à partir de "L'Émile" de Jean-Jacques Rousseau. L'association de l'un et l'autre texte nous permettra en effet de commenter la "seconde forme d'émotion" qui est très allusivement décrite par les dernières pages de l'Esquisse d'une théorie des émotions. Plus largement, ce détour par la philosophie politique des modernes permettra d'établir un dialogue entre la phénoménologie sartrienne de l'affectivité et l'approche de la normativité qui est proposée par la philosophie française des sciences sociales. [less ▲]

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See detailConstitutus = καϑεστώς : un hellénisme de la langue juridique ?
Rochette, Bruno ULiege

Conference (2017, April 26)

Le participe parfait constitutus (ainsi que positus) a été vu comme une sorte de substitut destiné à pallier l’absence en latin de participe présent du verbe être (*ens, entis). Plusieurs auteurs ont ... [more ▼]

Le participe parfait constitutus (ainsi que positus) a été vu comme une sorte de substitut destiné à pallier l’absence en latin de participe présent du verbe être (*ens, entis). Plusieurs auteurs ont considéré cet emploi comme un hellénisme propre à la langue juridique en soulignant que, dans les Novellae de Justinien, constitutus est une traduction du grec καϑεστώς, qui a un sens actif. On en a déduit qu’il pourrait s’agir d’une particularité de la langue des juristes qui apparaît pour la première fois chez Julianus [4], Scaevola [6], Papinien [5] et Ulpien [8]. Cet emploi, qui ne semble pas antérieur à Sénèque [7], n’est toutefois pas spécifique aux juristes. On le rencontre dans le latin de l’Empire, spécialement chez des auteurs africains chrétiens et païens, comme Apulée [2] et Cyprien de Carthage [3], et surtout dans la langue tardive (Ammien Marcellin [1]). Cet usage pose la question de la spécificité de la langue des juristes et de l’influence éventuelle du grec sur cette langue technique. Une étude plus systématique des prétendus hellénismes chez le juriste Gaius, peut-être d’origine orientale, montre que l’influence du grec sur son latin, si elle a existé, est assez réduite. Un grand nombre de particularités qui ont été considérées comme des hellénismes sont en réalité des spécificités du latin tardif et connaissent des parallèles chez des auteurs comme Apulée, Tertullien, Augustin, Ammien Marcellin. J’étudie ici les emplois de constitutus comme prétendu substitut du participe présent de esse dans un corpus assez large de textes : Arnobe, Firmicus Maternus, Lactance, Hilaire, Lucifer, Ambroise, Jérôme, Sulpice Sévère, Cassien, Orose… jusqu’à Cassiodore. On trouve aussi cette tournure assez souvent dans la Vulgate. Pour expliquer cette spécificité, l’influence du grec n’est pas une donnée nécessaire. Il s’agit essentiellement, comme d’autres phénomènes, d’une évolution du latin, qui a sans doute éprouvé le besoin de combler la lacune de l’absence du participe présent du verbe « être », ce qui arrivera au Moyen Âge avec la création de *ens, entis, déjà proposé par Jules César. Exemples [1] Ammien Marcellin, XX, 3, 12 : eodem adhuc constituto [2] Apulée, Mét., IV, 11 : Tunc nos in ancipiti periculo constituti uel op primendi nostri uel deserendi socii remedium e re nata ualidum eo uolente comminiscimus. [3] Cyprien, Ep., 1, 1 : in clerico ministerio constituti [4] Julianus Dig. 24, 2, 6 : in captiuitate constitutus [5] Papinien Dig. 35, 1, 77, 3 : impubere filia constituta [6] Scaevola Dig. 4, 4, 39, 1 : curatoribus eius idoneis constitutis [7] Sénèque, NQ, III, 10, 3 : natura partes suas velut in ponderribus constitutas exanimat [8] Ulpien Dig. 3, 5, 19 : Ulpianus libro decimo ad edictum. sin autem apud hostes constitutus decessit, et successori et aduersus successorem eius negotiorum gestorum directa et contraria competit. Bibliographie GARCEA A., Caesar’s De analogia. Edition, Translation, and Commentary, Oxford, 2012. KALB W., Das Juristenlatein. Versuch einer Charakteristik auf Grundlage der Digesten, Nürnberg 1888 [Aalen 1961] --, Roms Juristen nach ihrer Sprache dargestellt, Leipzig 1890 [Aalen 1975]. LÖFSTEDT E., Zur Frage der Gräzismen, dans Syntactica. Studien und Beiträge zur historischen Syntax des Lateins II, Lund 1933, 406-457 NELSON H.L.W., Überlieferung, Aufbau und Stil von Gai Institutiones (Studia Gaiana, 6), Leiden 1981, ROSÉN H.-D. SHLEV, QUASI: Its Grecizing [?] syntactic patterns, Colloque de Linguistique latine de Toulouse (sous presse). SCHRIJNEN J.-CHR. MOHRMANN, Studien zur Sprache der Briefe des hl. Cyprian, 2 vol., Nijmegen 1934 [less ▲]

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See detailLa revue L’Ossature métallique et le débat de l’architecture dans l’entre-deux- guerres
Charlier, Sébastien ULiege

Conference (2017, April 25)

Publiée à Bruxelles dès 1932, L’Ossature métallique est éditée par le Centre belgo-luxembourgeois d’information de l’acier pour faire face à la crise économique qui frappe durement l’industrie ... [more ▼]

Publiée à Bruxelles dès 1932, L’Ossature métallique est éditée par le Centre belgo-luxembourgeois d’information de l’acier pour faire face à la crise économique qui frappe durement l’industrie sidérurgique belge depuis 1929. Le mensuel traduit la volonté de l’industrie de disposer d’un organe d’information puissant relayant les dernières nouveautés en matière de constructions en acier. La revue se destine d’abord aux ingénieurs et propose de nombreuses études techniques (théories, calculs, essais) et des articles sur le rôle du métal dans le génie civil ou dans les moyens de transports (voitures de chemin de fer, locomotives, bateaux…). Très vite, L’Ossature métallique prend conscience des nouveaux marchés à toucher et prend pied dans le champ de l’architecture en proposant des articles sur des bâtiments à structure métallique. Puisant d’abord ses articles dans la presse internationale, la revue peut bientôt compter sur des articles originaux témoignant d’un réseau d’auteurs étendus et aux profils variés. Après avoir situé l’organe dans le fascinant bouillonnement des revues d’architecture de l’entre-deux-guerres, l’exposé montrera, à travers une sélection d’articles traitant en priorité de réalisations situées en Wallonie, de la variété des sujets traités par L’Ossature métallique. De la petite maison individuelle à l’immeuble à appartements en passant par les infrastructures publiques ou les bâtiments industriels, l’exposé proposera quelques expressions de l’architecture métallique en Belgique. [less ▲]

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See detailCharacteristics of surface chlorophyll-a concentrations in the South China Sea
Huynh, Thi Hong Ngu ULiege; Alvera Azcarate, Aida ULiege; Barth, Alexander ULiege et al

Poster (2017, April 25)

In this study, the spatial and temporal variability of surface chlorophyll-a (Chl-a) concentrations in the South China Sea (SCS) is investigated, using the cloud-free MODISA Chl-a data set (2003-2016 ... [more ▼]

In this study, the spatial and temporal variability of surface chlorophyll-a (Chl-a) concentrations in the South China Sea (SCS) is investigated, using the cloud-free MODISA Chl-a data set (2003-2016) reconstructed by the Data Interpolating Empirical Orthogonal Functions technique. EOF analysis on the reconstructed data set presents the characteristics of the surface Chl-a: (1) the first mode presents the high Chl-a concentrations in the coastal regions, except those of the Palawan and Philippines, generally with peaks in summer (June-July) and winter (November-December). (2) the second mode shows the seasonal variability of Chl-a in the whole basin, increasing in winter and decreasing in summer. (3) the third mode highlights the out-of-phase variability of the southern SCS Chl-a between the west and east coasts in winter and summer. The analysis also indicates that the variability of surface Chl-a is influenced by ENSO with a time lag of 5-9 months. [less ▲]

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See detailPopular Candidates and/or Party Soldiers? The Interactive Effect of Candidates’ Vote-Earning Capacity and the Candidate-Party Congruence at the 2014 Belgium Elections
Dodeigne, Jérémy ULiege; Meulewaeter, Conrad

Conference (2017, April 25)

Political parties need to act as unitary actors in parliaments to implement their policy goals. The literature has acknowledged that candidate selection process is one of the most powerful tools for a ... [more ▼]

Political parties need to act as unitary actors in parliaments to implement their policy goals. The literature has acknowledged that candidate selection process is one of the most powerful tools for a party to achieve and maintain internal cohesion within the parliamentary group. Political parties that do not win election cannot develop their policy goals though. Candidate selection processes present thus two – potentially conflicting – objectives: vote-seeking strategy (recruiting ‘popular candidates’) and policy-seeking strategy (enlisting ‘party soldiers’). The personalization of politics, where electoral campaigns are increasingly personal while eroding the role of issues and ideology in voting behaviour, enhances the tensions between parties’ vote-seeking and policy-seeking strategies. According to some scholars, the former even prevails over the other which causes critical consequences for the functioning of parties in legislature and the broader democratic political systems. However, in line with more recent development in the literature, we argue that personalization is not necessarily a zero-sum game: political parties can balance tickets using both strategies. In that configuration, one strategy interacts with the other, rather than prevail over the other. Using an innovative and consistent measurement of candidate-party congruence, we test this interaction on the recruitment of candidates at the 2014 Belgian elections. Overall, our results prove that vote-seeking strategy matters but heavily depends on policy-seeking strategy. It demonstrates that parties use both strategies as a trade-off to balance their lists, even though vote-seeking strategy ultimately prevails for a substantial number of candidates studied. The results call for a more positive normative account of the personalization thesis. The later has the potential to keep voters, candidates and parties connected in the representation process. [less ▲]

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See detailDetermining fine population structure using iterative pruning
Chaichoompu, Kridsadakorn ULiege; Yazew, Fentaw Abegaz; Tongsima, Sissades et al

Poster (2017, April 25)

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See detailEFFECT OF FENTANYL INFUSION ON MINIMAL ALVEOLAR CONCENTRATION IN ISOFLURANE ANAESTHETISED HORSES – PRELIMINARY RESULTS
Vanaga, Jana; Kovalcuka, Liga; Sandersen, Charlotte ULiege

Poster (2017, April 25)

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See detailHow phosphorus limitation can control climatic gas sources and sinks
Gypens, N; Borges, Alberto ULiege; Ghyoot, C

Poster (2017, April 25)

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See detailThaw pond dynamics and carbon emissions in a Siberian lowland tundra landscape
Van Huissteden, J.; Heijmans, M.M.P.D.; Dean, J. et al

Poster (2017, April 25)

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See detailPredicting gully densities at sub-continental scales: a case study for the Horn of Africa
Vanmaercke, Matthias ULiege; Pelckmans, Ignace; Poesen, Jean

Conference (2017, April 25)

Gully erosion is a major cause of land degradation in many regions, due to its negative impacts on catchment hydrology, its associated losses of land and damage to infrastructure, as well as its often ... [more ▼]

Gully erosion is a major cause of land degradation in many regions, due to its negative impacts on catchment hydrology, its associated losses of land and damage to infrastructure, as well as its often major contributions to catchment sediment yields. Mitigation and prevention of gully erosion requires a good knowledge of its spatial patterns and controlling factors. However, our ability to simulate or predict this process remains currently very limited. This is especially the case for the regional scale. Whereas detailed case studies have provided important insights into the drivers of gully erosion at local scales, these findings are often difficult to upscale to larger regions. Here we utilized a simple and cheap method to predict patterns of gully density at the sub-continental scale. By means of a random sampling procedure, we mapped gully densities for over sixty study sites across the Horn of Africa, using freely available Google Earth imagery. Next, we statistically analyzed which factors best explained the observed variation in mapped gully density. Based on these findings, we constructed a multiple regression model that simulates gully density, based on topography (average slope), soil characteristics (percentage silt) and land use (NDVI-value). Although our model could benefit from further refinement, it succeeds already fairly well in simulating the patterns of gully density at sub-continental scales. Over 75% of the predicted gully densities differ less than 5% from the observed gully density, while over 90% of the predictions deviate less than 10%. Exploration of our results further showed that this methodology may be highly useful to quantify total gully erosion rates at regional and continental scales as well as the contribution of gully erosion to catchment sediment yields. [less ▲]

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See detailPromoting vaginal distribution of two active siRNA-complexed in liposomes for cervical cancer treatment
Lechanteur, Anna ULiege; Furst Tania; Evrard, Brigitte ULiege et al

Conference (2017, April 25)

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See detailOn a conjecture about regularity and l-abelian complexity
Vandomme, Elise ULiege

Conference (2017, April 25)

A natural generalization of automatic sequences over an infinite alphabet is given by the notion of k-regular sequences, introduced by Allouche and Shallit in 1992. The k-regularity of a sequence provides ... [more ▼]

A natural generalization of automatic sequences over an infinite alphabet is given by the notion of k-regular sequences, introduced by Allouche and Shallit in 1992. The k-regularity of a sequence provides us with structural information about how the different terms are related to each other. We show that a sequence satisfying a certain symmetry property is 2-regular. We apply this theorem to develop a general approach for studying the l-abelian complexity of 2-automatic sequences. In particular, we prove that the period-doubling word and the Thue–Morse word have 2-abelian complexity sequences that are 2-regular. The computation and arguments leading to these results fit into a quite general scheme that can be used to obtain additional regularity results. This supports the conjecture that the l-abelian complexity of a $k$-automatic sequence is a k-regular sequence. [less ▲]

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See detailMultiple Semantic Priming and Latin Sequential Collocations : when Text Linguistics and Language Learning meet Cognitive Psychology
Lavigne, Frederic; Longrée, Dominique ULiege; Mellet, Sylvie

Conference (2017, April 25)

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See detailSalinity impact on seed yield, polyphenols composition and antioxidant activity of Fennel (Foeniculum vulgarae Mill) extracts
Bettaieb Rebey, Ines; Bourgou, S.; Msaada, K. et al

Poster (2017, April 24)

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See detailCharacterizing root system characteristics with Electrical resistivity Tomography: a virtual rhizotron simulation
Rao, Sathyanarayan; Ehosioke, Solomon ULiege; Lesparre, Nolwenn et al

Conference (2017, April 24)

Electrical Resistivity Tomography (ERT) is more and more used for monitoring soil water content in a cropped soil. Yet, the impact of roots on the signal is often neglected and a topic of controversy. In ... [more ▼]

Electrical Resistivity Tomography (ERT) is more and more used for monitoring soil water content in a cropped soil. Yet, the impact of roots on the signal is often neglected and a topic of controversy. In several studies related to soil-root system, it has been showed that the measured root mass density statistically correlates with the electrical conductivity (EC) data obtained from ERT. In addition, some studies suggest that some roots are more electrically conductive than soil for most water content. Thus, higher EC of roots suggest that it might have a measurable impact on ERT signals. In this work, virtual rhizotrons are simulated using the software package called R-SWMS that solves water and solute transport in plant root-soil system, including root growth. The distribution of water content obtained from R-SWMS simulation is converted into EC data using pedo-physical models. The electrical properties of roots and rhizosphere are explicitly included in the EC data to form a conductivity map (CM) with a very detailed spatial resolution. Forward ERT simulations is then carried out for CM generated for various root architectures and soil conditions to study the impact of roots on ERT forward (current and voltage patterns) and inverse solutions. It is demonstrated that under typical injection schemes with lateral electrodes, root system is hardly measurable. However, it is showed that adding electrodes and constraints on the ERT inversion based on root architecture help quantifying root system mass and extent. [less ▲]

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See detailA terminology in General Practice / Family Medicine to represent non-clinical aspects for various usages
Jamoulle, Marc ULiege; Grosjean, Julien; Ittoo, Ashwin ULiege et al

in R. Randell et al. (Ed.) Informatics for Health: Connected Citizen-Led Wellness and Population Health (2017, April 24)

Abstract. The hereby proposed terminology called “Q-Codes” can be defined as an extension of the International Classification of Primary Care (ICPC-2). It deals with non-clinical concepts that are ... [more ▼]

Abstract. The hereby proposed terminology called “Q-Codes” can be defined as an extension of the International Classification of Primary Care (ICPC-2). It deals with non-clinical concepts that are relevant in General Practice/Family Medicine (GP/FM). This terminology is a good way to put an emphasis on underestimated topics such as Teaching, Patient issues or Ethics. It aims at indexing GP/FM documents such as congress abstracts and theses to get a more comprehensive view about the GP/FM domain. The 182 identified Q-Codes have been very precisely defined by a college of experts (physicians and terminologists) from twelve countries. The result is available on the Health Terminology/Ontology Portal (http://www.hetop.org/Q) and formatted in OWL-2 for further semantic considerations and will be used to index the 2016 WONCA World congress communications. [less ▲]

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See detailAvatars et actualité de la phénoménotechnique
Pieron, Julien ULiege

Conference (2017, April 24)

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See detailLymphatic vasculature requires estrogen receptor alpha signaling to protect from lymphedema
Morfoisse, Florent ULiege

Conference (2017, April 24)

Rationale: Estrogen play a crucial role on the cardiovascular system and, particularly, on the vascular endothelium. However, the effect of estrogen on the lymphatic system has been poorly investigated ... [more ▼]

Rationale: Estrogen play a crucial role on the cardiovascular system and, particularly, on the vascular endothelium. However, the effect of estrogen on the lymphatic system has been poorly investigated. Objective: We aimed to demonstrate the protective effect of the 17 estradiol (E2), the most potent endogenous estrogen in lymphedema, a lymphatic dysfunction, which results in a massive fluid and fat accumulation. Methods and Results: Immunohistochemistry revealed that high doses of E2 modified skin microenvironment and stimulated lymphangiogenesis. E2 activates lymphatic endothelium through a transcriptional activation induced by its receptor ER. Using an original model of secondary lymphedema, we found a protective effect of E2 that prevents limb swelling. Loss of ER function using selective estrogen modulator (SERM) and in Tie2 Cre(+); ER-/- mice lead to a disruption of the lymphatic network promoting lymphedema. This effect was associated with a remodeling of LEC, an inhibition of gene expression, and ERK, but not AKT E2-induced phosphorylation. Conclusion: These findings reveal a new facet of the influence of estrogens in the management of the lymphatic system in pathological condition and provides more evidences that secondary lymphedema is not only a side effect of surgery, but is worsen by hormone therapy. [less ▲]

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