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See detailEffective soil hydraulic conductivity predicted with the maximum power principle
Westhoff, Martijn ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

Conference (2016, April)

Drainage of water in soils happens for a large extent through preferential flowpaths, but these subsurface flowpaths are extremely difficult to observe or parameterize in hydrological models. To ... [more ▼]

Drainage of water in soils happens for a large extent through preferential flowpaths, but these subsurface flowpaths are extremely difficult to observe or parameterize in hydrological models. To potentially overcome this problem, thermodynamic optimality principles have been suggested to predict effective parametrization of these (sub-grid) structures, such as the maximum entropy production principle or the equivalent maximum power principle. These principles have been successfully applied to predict heat transfer from the Equator to the Poles, or turbulent heat fluxes between the surface and the atmosphere. In these examples, the effective flux adapts itself to its boundary condition by adapting its effective conductance through the creation of e.g. convection cells. However, flow through porous media, such as soils, can only quickly adapt its effective flow conductance by creation of preferential flowpaths, but it is unknown if this is guided by the aim to create maximum power. Here we show experimentally that this is indeed the case: In the lab, we created a hydrological analogue to the atmospheric model dealing with heat transport between Equator and poles. The experimental setup consists of two freely draining reservoirs connected with each other by a confined aquifer. By adding water to only one reservoir, a potential difference will build up until a steady state is reached. From the steady state potential difference and the observed flow through the aquifer, and effective hydraulic conductance can be determined. This observed conductance does correspond to the one maximizing power of the flux through the confined aquifer. Although this experiment is done in an idealized setting, it opens doors for better parameterizing hydrological models. Furthermore, it shows that hydraulic properties of soils are not static, but they change with changing boundary conditions. A potential limitation to the principle is that it only applies to steady state conditions. Therefore the rate of adaptation of hydraulic properties should be faster than the rate of change in boundary conditions. [less ▲]

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See detailThe contribution of air-fluidization to the mobility of rapid flowslides
Stilmant, Frédéric; Dewals, Benjamin ULg; Archambeau, Pierre ULg et al

Conference (2016, April)

Air-fluidization can be the origin of the long runout of gravitational flows involving fine particles such as ash. An excessive air pore pressure dramatically reduces the friction angle of the material as ... [more ▼]

Air-fluidization can be the origin of the long runout of gravitational flows involving fine particles such as ash. An excessive air pore pressure dramatically reduces the friction angle of the material as long as this pressure has not been dissipated, which occurs during the flow. This phenomenon can be modelled thanks to the 2D depth-averaged equations of mass and momentum conservation and an additional transport equation for basal pore pressure evolu- tion (Iverson and Denlinger, 2001). ln this contribution, we discuss the application of this model in relation to recent experimental results on air- fluidized flows by Roche et al. (2008) and Roche (2012). The experimental results were used to set a priori the value of the diffusion coefficient in the model, taking into account the diference of scale between the experiments and real-world applications. We also compare the model predictions against detailed observations of a well-documented historical event, the collapse of a fly-ash heap in Belgium (Stilmant et al., 2015). In particular, we analyse the influence of the different components of the model on the results (pore pressure dissipation vs. pore pressure generation). The diffusion coefficient which characterizes the dissipation of air pore pressure is found sufficiently low for maintaining a fluidized flow over hundreds of meters. The study concludes that an air-tluidization theory is consistent with the field observations. These findings are particularly interesting as they seem not in line with the mainstream acceptation in landslide modelling that air generally plays a secondary role (e.g., Legros, 2002). [less ▲]

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See detailL'imagination. Une pratique normée chez Wittgenstein
Gauvry, Charlotte ULg

Conference (2016, April)

Contrairement aux empiristes anglais, Wittgenstein récuse l’idée d’après laquelle les actes d’imagination sont définis par leur « contenu », à savoir une « image mentale » qui ne différerait que par son ... [more ▼]

Contrairement aux empiristes anglais, Wittgenstein récuse l’idée d’après laquelle les actes d’imagination sont définis par leur « contenu », à savoir une « image mentale » qui ne différerait que par son degré d’intensité d’un contenu cognitif (Cf. Hume, Traité de la nature humaine, I, i, 3 ; Wittgenstein, F §621). Parallèlement, Wittgenstein récuse l’hypothèse selon laquelle un « œil mental » ou « œil interne » nous fournirait ces images (cf. e.g. RPP II §66). De fait, les nombreux exemples des Recherches philosophiques comme des textes plus tardifs (cf. e.g. RP §§6, 19 ; F §§98, 571) mettent en scène l’imagination d’un langage, d’une hypothèse, d’un usage, d’un contexte, etc. – autant de choses que l’on ne « voit » pas par l’œil de l’esprit. En adoptant une position assez proche de celles de Reid, Ryle ou Sartre (cf. Glock 1996), Wittgenstein défend alors l’hypothèse d’une imagination sans imaginaire. Ce faisant, Wittgenstein présente l’imagination comme un acte, ou plutôt une « pratique ». Or Wittgenstein dissocie cette pratique de celle de la perception (F §§621-637). Selon le §625 des Fiches, il existe bien un « rapport » entre ces deux jeux de langage, mais pas de « ressemblance ». À titre de premières indications, il semble que les deux pratiques diffèrent pour au moins trois raisons : - Premièrement, Wittgenstein affirme que l’imagination, à la différence de la perception, est assujettie à la volonté (e.g. F §621). Si nous recevons ce que nous percevons, nous pouvons en revanche répudier ou rechercher certaines images. - Qui plus est, en tant que pratique volontaire, l’imagination est soumise aux mêmes règles que celles qui régulent toutes les pratiques. C’est donc une pratique normée : en situation, certaines représentations sont possibles alors que d’autres pas (cf. e.g. RP, §651 : « je ne peux pas imaginer le contraire »). - Il semble enfin que l’imagination, à la différence de la perception, soit une pratique créatrice. Wittgenstein rapproche en effet l’imagination du « voir comme » et non du voir (RP II, 11, RPP §543). Elle joue à ce titre un rôle méthodologique fondamental dans l’économie de la vision synoptique que Wittgenstein appelle de ses vœux. [less ▲]

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See detailDesign optimization of large-size format edge-lit light guide units
Hastanin, Juriy ULg; Lenaerts, Cedric ULg; Fleury-Frenette, Karl ULg

in Proceedings of SPIE; SPIE 2016 Photonics Europe (2016, April)

In this paper, we present an original method of dot-pattern generation dedicated to design optimization of large-size format ELBUs (Edge-Lit Light Guide Unit), where the number of dots greatly exceeds the ... [more ▼]

In this paper, we present an original method of dot-pattern generation dedicated to design optimization of large-size format ELBUs (Edge-Lit Light Guide Unit), where the number of dots greatly exceeds the maximum allowable number of optical objects supported by most common ray-tracing software. In the proposed method, in order to simplify the computational problem, an original optical system is replaced by an equivalent one. Accordingly, the original dot pattern is splitted into multiple small sections. Then, these sections are replaced by equivalent cells with continuous diffusing film. After that, we adjust the TIS (Total Integrated Scatter) two-dimensional distribution over the grid of equivalent cells, using an iterative optimization procedure. Finally, the obtained optimal TIS distribution is converted into the dot size distribution by applying an appropriate conversion rule. An original semi-empirical equation dedicated to rectangular large-size LGPs (Light Guide Plate) is proposed for the initial guess of the TIS distribution. It allows significantly reducing the time needed to dot pattern optimization. [less ▲]

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See detailDistribution of uncertainties at the municipality level for flood risk modelling along the river Meuse: implications for policy-making
Pirotton, Michel ULg; Stilmant, Frédéric; Erpicum, Sébastien ULg et al

Conference (2016, April)

Flood risk modelling has been conducted for the whole course of the river Meuse in Belgium. Major cities, such as Liege (200,000 inh.) and Namur (l 10,000 inh.), are located in the floodplains of river ... [more ▼]

Flood risk modelling has been conducted for the whole course of the river Meuse in Belgium. Major cities, such as Liege (200,000 inh.) and Namur (l 10,000 inh.), are located in the floodplains of river Meuse. Particular attention has been paid to uncertainty analysis and its implications for decision-making. The modelling chain contains flood frequency analysis, detailed 2D hydraulic computations, damage modelling and risk calculation. The relative importance of each source of uncertainty to the overall results uncertainty has been estimated by considering several alternate options for each step of the analysis; different distributions were considered in the flood frequency analysis; the influence of modelling assumptions and boundary conditions (e.g., steady vs. unsteady) were taken into account for the hydraulic computation; two different landuse classifications and two sets ofdamage functions were used; the number of exceedance probabilities involved in the risk calculation (by integration of the risk-curves) was varied. In addition, the sensitivity of the results with respect to increases in flood discharges \vas assessed. The considered increases are consistent with a "wet" climate change scenario for the time horizons 202l~2050 and 2071-2100 (Detrembleur et al., 2015). The results of hazard computation differ significantly between the upper and lower parts of the course of river Meuse in Belgium. In the former, inundation extents grow gradually as the considered flood discharge is increased (i.e. the exceedance probability is reduced), while in the downstream part, protection structures (mainly concrete walls) prevent inundation for flood discharges corresponding to exccedance probabilities of 0.01 and above (in the present climate). For higher discharges, large inundation extents are obtained in the floodplains. The highest values of risk (mean annual damage) are obtained in the municipalities which undergo relatively frequent flooding (upper part of the river), as well as in those of the downstream part of the Meuse in which flow depths in the urbanized floodplains are particularly high when inundation occurs. This is the case of the city of Liege, as a result of a subsidence process following former mining activities. For a given climate scenario, the uncertainty ranges affecting flood risk estimates are significant; but not so much that the results for the different municipalities would overlap substantially. Therefore, these uncertainties do not hamper prioritization in terms of allocation of risk reduction measures at the municipality level. In the present climate, the uncertainties arising from flood frequency analysis have a negligible influence in the upper part of the river, while they have a considerable impact on risk modelling in the lower part, where a threshold effect was observed due to the flood protection structures (sudden transition from no inundation to massive flooding when a threshold discharge is exceeded). Varying the number of exceedance probabilities in the integration of the risk curve has different effects for different municipalities; but it does not change the ranking of the municipalities in terms of flood risk. For the other scenarios, damage estimation contributes most to the overall uncertainties. As shown by this study, the magnitude of the uncertainty and its main origin vary in space and in time. This emphasizes the paramount importance of conducting distributed uncertainty analyses. In the considered study area, prioritization of risk reduction means can be reliably performed despite the modelling uncertainties. [less ▲]

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See detailThermal and quantum depletion of superconductivity in narrow junctions created by controlled electromigration
Silhanek, Alejandro ULg

Conference (2016, April)

Superconducting nanowires have been, for years now, a topic of great interest due to their potential application in single photon detectors and as interconnects in circuits proposed for quantum computing ... [more ▼]

Superconducting nanowires have been, for years now, a topic of great interest due to their potential application in single photon detectors and as interconnects in circuits proposed for quantum computing. In this context, it is of fundamental importance to better understand the undesired and harmful appearance of thermal and quantum fluctuations of the superconducting order parameter as a function of the wire width. In this presentation, we explore in-situ controlled electromigration (EM) to fabricate nano-constrictions immersed in cryogenic environment. We demonstrate that a transition from thermally assisted phase slips (TAPS) to quantum phase slips (QPS) takes place when the effective cross section becomes smaller than ~150 nm^2. In the regime dominated by QPS the nanowire loses completely its capacity to carry current without dissipation, even at the lowest possible temperature. We also demonstrate that the bow-tie shaped constrictions exhibit a negative magnetoresistance at low magnetic fields which can be attributed to the suppression of superconductivity in the contact leads. Strikingly, the detrimental effect caused by the repeated EM can be healed by simply inverting the current direction. These findings reveal perspectives of the proposed fabrication method for exploring various fascinating superconducting phenomena in atomic size constrictions. [less ▲]

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See detailMAVEN Imaging UV Spectrograph Results on the Mars Atmosphere and Atmospheric Escape
Chaffin; Schneider; McClintock et al

Conference (2016, April)

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See detailUnveiling the MPLS Structure on Internet Topology
Davila Revelo; Anderson Ricci, Mauricio; Donnet, Benoît ULg et al

in 8th International Workshop on Traffic Monitoring and Analysis (TMA) (2016, April)

Recently, researches have been conducted to discover and assess the usage of MPLS tunnels. Indeed, recent developments in the ICMP protocol make certain categories of MPLS tunnels transparent to ... [more ▼]

Recently, researches have been conducted to discover and assess the usage of MPLS tunnels. Indeed, recent developments in the ICMP protocol make certain categories of MPLS tunnels transparent to traceroute probing. Additional techniques have been proposed to reveal the presence of MPLS tunnels when they do not explicitly appear in traceroute. It has been shown that MPLS is a very well deployed technology whose usage (i.e., Traffic Engineering, load balancing, etc.) varies in time and according to ASes. However, the MPLS structure on the Internet architecture has not been studied yet. In this paper, we follow this path by providing two contributions to the state of the art: (i) we evaluate the biases involved on MPLS tunnel detection when they are not directly revealed through traceroute. (ii), we provide some properties and architectural details related with MPLS deployment on router topology based on a k-core decomposition. [less ▲]

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See detailInfluence of the ionospheric model on DCB computation and added value of LEO satellites
Wautelet, Gilles ULg; Lestarquit, Laurent; Loyer, Sylvain et al

Poster (2016, April)

In order to compute inter-frequency Differential Code Biases (DCBs), the Geometry-Free combination of a GNSS signal pair needs to be corrected from the ionospheric refraction effect. Such information is ... [more ▼]

In order to compute inter-frequency Differential Code Biases (DCBs), the Geometry-Free combination of a GNSS signal pair needs to be corrected from the ionospheric refraction effect. Such information is obtained using either Global Ionospheric Maps (GIMs) or local models. In this work we investigate the influence of GIMs on the final value and precision of DCB solution. The study covers different ionospheric conditions, ranging from very quiet ionospheric background up to a severe ionospheric storm. In a first step, the Slant Total Electron Content (STEC) between GIMs is assessed as a function of receiver latitude, elevation mask and ionospheric conditions. Then, daily DCBs are estimated using these different GIMs, receiver and satellite contributions being separated using a zero-mean constraint. At last, an independent estimation of DCBs is performed using Low Earth Orbit (LEO) observations (such as JASON's GPS data). This solution is compared with our ground network solution and with DCBs coming from Analysis Centers (ACs) of the International GNSS Service providing ionospheric and DCB solutions. [less ▲]

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See detailLes théories représentationnelles de l'esprit
Gauvry, Charlotte ULg

Conference (2016, April)

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See detailThe Fractal Nature of Mars Topography Analyzed via the Wavelet Leaders Method
Kleyntssens, Thomas ULg; Deliège, Adrien ULg; Nicolay, Samuel ULg

in Information Technology: New Generations (2016, April)

This paper studies the scaling properties of Mars topography based on Mars Orbiter Laser Altimeter (MOLA) data through the wavelet leaders method (WLM). This approach shows a scale break at 15 km. At ... [more ▼]

This paper studies the scaling properties of Mars topography based on Mars Orbiter Laser Altimeter (MOLA) data through the wavelet leaders method (WLM). This approach shows a scale break at 15 km. At small scales, these topographic profiles display a monofractal behavior while a multifractal nature is observed at large scales. The scaling exponents are greater at small scales. They also seem to be influenced by latitude and may indicate a slight anisotropy in topography. [less ▲]

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See detailDoes the Budyko curve reflect a maximum power state of hydrological systems? A backward analysis
Westhoff, Martijn ULg; Zehe, Erwin; Archambeau, Pierre ULg et al

Conference (2016, April)

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we ... [more ▼]

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we applied the thermodynamic principle of maximum power as the organizing principle. In a top-down approach we derived mathematical formulations of the relation between relative wetness and gradients driving runoff and evaporation for a simple one-box model. We did this in an inverse manner such that when the conductances are optimized with the maximum power principle, the steady state behaviour of the model leads exactly to a point on the asymptotes of the Budyko curve. Subsequently, we added dynamics in forcing and actual evaporations, causing the Budyko curve to deviate from the asymptotes. Despite the simplicity of the model, catchment observations compare reasonably well with the Budyko curves subject to observed dynamics in rainfall and actual evaporation. Thus by constraining the – with the maximum power principle optimized – model with the asymptotes of the Budyko curve we were able to derive more realistic values of the aridity and evaporation index without any parameter calibration. [less ▲]

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See detailreactive gases in the chemistry climate model ECHAM6-HAMMOZ
Schultz, Martin; Taraborrelli, Domenico; Stadtler, Scarlet et al

Conference (2016, April)

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See detailNew elicitors as biocontrol tools to protect wheat against Septoria Tritici Blotch
Le Mire, Géraldine ULg; SIAH, Ali; Jijakli, Haissam ULg

Poster (2016, April)

Wheat is one of the most cultivated crops in the European Union. This cereal must however face important losses every year due to a major foliar disease known as Septoria Tritici Blotch (STB) caused by ... [more ▼]

Wheat is one of the most cultivated crops in the European Union. This cereal must however face important losses every year due to a major foliar disease known as Septoria Tritici Blotch (STB) caused by the fungus Zymoseptoria tritici. Disease control mainly depends on phytosanitary products. However, conventional agriculture is evolving towards more sustainable practices, out of respect for human health and the environment. Elicitors are considered as promising biological control tools and draw major interest in Integrated Pest Management strategies. These plant-immunity triggering compounds induce a general systemic resistance of the plant to a large spectrum of diseases. This study focuses on the screening of nine potential elicitors to protect winter wheat against Zymoseptoria tritici. Greenhouse trials were carried out to measure the ability of the different products to reduce disease foliar symptoms (necrosis, chlorosis and pycnidia). In addition, the biocide activity of these products towards the pathogen was evaluated under greenhouse and laboratory conditions. Furthermore, the modes of action of the best elicitors were investigated by studying the activity of some key defense enzymes of wheat. The corresponding results will be presented and discussed with the perspective to choose the two best elicitors for field trials and undertake further investigations on the signaling pathways triggered in the plant. [less ▲]

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See detailMapping cortical modules, their connectivity and functions
Genon, Sarah ULg; Eickhoff, Simon

Conference (2016, April)

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See detailEnvironmental Impact Assessment of Rail Freight Intermodality
Merchan Arribas, Angel ULg; Belboom, Sandra ULg; Léonard, Angélique ULg

in Pombo, Joao (Ed.) The Third International Conference on Railway Technology: Research, Development and Maintenance (2016, April)

The European Commission’s White Paper on transport seeks to achieve an efficient and sustainable balance between the various transport modes. In this context, BRAIN-TRAINS is a project supported by ... [more ▼]

The European Commission’s White Paper on transport seeks to achieve an efficient and sustainable balance between the various transport modes. In this context, BRAIN-TRAINS is a project supported by Belgian Federal Government that deals with rail freight intermodality, approaching the problem from an interdisciplinary perspective. BRAIN-TRAINS will be able to answer the transition involved in transportation in Belgium. To analyse the sustainability impact of rail freight intermodality in Belgium, the life cycle assessment methodology will be used. The rail freight system is divided in this paper into rail operation, rail equipment and rail infrastructure. This paper shows the methodology to calculate the transport emissions related with the energy consumption during the rail operation. [less ▲]

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See detailSingle molecule force spectroscopy on oligorotaxane foldamers
Sluysmans, Damien ULg; Stoddart, J. Fraser; Duwez, Anne-Sophie ULg

Conference (2016, April)

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See detailCO2-based sustainable polymers: from CO2-sourced monomers to low CO2 emission foamed materials
Grignard, Bruno ULg; Gennen, Sandro ULg; Alves, Margot ULg et al

Conference (2016, April)

Due to concerns about the climate change combined with the decrease of fossil resources, the use of CO2 as a C1 feedstock for producing added value chemicals and materials has become a huge challenge in ... [more ▼]

Due to concerns about the climate change combined with the decrease of fossil resources, the use of CO2 as a C1 feedstock for producing added value chemicals and materials has become a huge challenge in academic laboratories and in industry. The coupling of CO2 with epoxide has emerged as one of the most promising way to convert CO2 into cyclic carbonates finding application as green solvents or electrolyte for batteries. Interestingly, these cyclic carbonates can also be valorised as monomers to produce new non-isocyanate polyurethanes by step-growth polymerization with amines. Polyurethane (PU) is one of the most important polymers in our everyday life with numerous applications such as thermosets, thermoplastics, elastomers, adhesives, sealants, coatings, rigid and flexible foams for wellness or acoustic and/or thermal insulation. In this talk, we will discuss the preparation of all green bio- and CO2-sourced non-isocyanate polyurethane (NIPU) microcellular foams with thermal insulation properties by using an eco-efficient process based on the supercritical carbon dioxide (scCO2) foaming technology. This talk will be divided in three sections: The synthesis of CO2-sourced cyclic carbonates by coupling CO2 with epoxides using a new highly-efficient bicomponent homogeneous organocatalyst combining the use of an ammonium salt as the catalyst and a fluorinated hydrogen bond donor activator that allows the fast and solvent-free coupling of CO2 with (biosourced) epoxides under mild experimental conditions. The synthesis of (bio- and) CO2-sourced isocyanates-free PUs by melt step-growth copolymerization, eliminating the toxicological issues associated to the conventional synthesis of polyurethanes from diols and isocyanates. The foaming of NIPUs by exploiting the scCO2 foaming technology. By finely choosing the appropriate CO2 impregnation and foaming conditions, thermally insulating CO2-blown microcellular NIPUs foams were produced. [less ▲]

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See detailModeling of the cyclic lipodepsipeptide Pseudodesmin A self-assembly through molecular dynamic simulations
Crowet, Jean-Marc ULg; Sinnaeve, Davy; Fehér, Kristina et al

Poster (2016, April)

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See detailrelationship between total hip BMD T-score and incidence of nonvertebral fracture with up to 10 years of Denosumab (DMAB) treatment
Ferrari, S.; ADAMI, S.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 49-50

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See detailRhizosecreted proteases inhibition for the improvement of recombinant protein production in Arabidopsis thaliana
Lallemand, Jérôme ULg; Périlleux, Claire ULg; Tocquin, Pierre ULg

Poster (2016, April)

Plant-based biopharmaceuticals have gained a lot of interest in the past decade due to their reduced cost and relative safety compared to mammalian cell cultures. While the first plant-made recombinant ... [more ▼]

Plant-based biopharmaceuticals have gained a lot of interest in the past decade due to their reduced cost and relative safety compared to mammalian cell cultures. While the first plant-made recombinant proteins are now reaching the market, the production systems still need improvements to maximize their competitiveness. Optimizing production hosts requires the identification and subsequent inhibition of the most active endogenous peptidases, proteolysis being one of the main factors limiting yields. The aim of our study was to identify root-secreted proteases of Arabidopsis thaliana involved in target protein degradation (BSA) and inhibit them in vivo. Biochemical analyses identified serine proteases as the main class responsible for BSA degradation. An RT-qPCR experiment led to the choice of the serine protease gene SBT4.12 and its homologs as targets for an amiRNA-mediated silencing approach. Arabidopsis amiRNA-expressing lines showed lower levels of expression for SBT4.12 and reduced proteolytic activity in their rhizosecreted extracts. Crossing these lines with recombinant protein producing lines could lead to an improved production platform for proteins of interest. [less ▲]

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See detailThe future prevalence of sarcopenia in Europe
Ethgen, Olivier ULg; Tchoconte, C.; Beaudart, Charlotte ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 53-54

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See detailSafety of avelumab (MSB0010718C), an anti-PD-L1 antibody : updated analysis from the phase Ib JAVELIN solid tumor trial
Kelly, K.; Patel, M.; Infante, J.R. et al

Conference (2016, April)

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See detailA randomized double-blind study of Denosumab (DMAB) compared with Zoledronic acid (ZOL) in postmenopausal women with osteoporosis previously treated with oral bisphosphonates
Miller, P.; Pannacciulli, N.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(SUPPLEMENT1), 42

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See detailImproved Thévenin equivalent methods for real-time voltage stability assessment
Perez, Angel; Johannsson, Hjortur; Ostergaard, Jacob et al

in proc. IEEE ENERGYCON Conference (2016, April)

An improved Thévenin equivalent method for real-time voltage stability assessment that uses wide-area information from synchrophasors is proposed. The improvements are a better modeling of the limited ... [more ▼]

An improved Thévenin equivalent method for real-time voltage stability assessment that uses wide-area information from synchrophasors is proposed. The improvements are a better modeling of the limited synchronous generators, and a processing that anticipates the effect of field current limiters, before the latter are activated. Several study cases using detailed dynamic simulations of the Nordic test system have been used to assess the performance of the proposed improvements. Their effectiveness is analyzed and, based on the results, their possible application in combination with the sensitivity-based voltage stability assessment method is explored. [less ▲]

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See detailMars Topography Investigated Through the Wavelet Leaders Method: a Multidimensional Study of its Fractal Structure
Deliège, Adrien ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

Poster (2016, April)

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based ... [more ▼]

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based on Mars Orbiter Laser Altimeter (MOLA) data using the multifractal formalism called Wavelet Leaders Method (WLM). This approach shows that a scale break occurs at approximately 15 km, giving two scaling regimes in both 1D and 2D cases. At small scales, these topographic profiles mostly display a monofractal behavior while a switch to multifractality is observed in several areas at larger scales. The scaling exponents extracted from this framework tend to be greater at small scales. In the 1D context, these observations are in agreement with previous works and thus suggest that the WLM is well-suited for examining scaling properties of topographic fields. Moreover, the 2D analysis is the first such complete study to our knowledge. It gives both a local and global insight on the scaling regimes of the surface of Mars and allows to exhibit the link between the scaling exponents and several famous features of the Martian topography. These results may be used as a solid basis for further investigations of the scaling laws of the Red planet and show that the WLM could be used to perform systematic analyses of the surface roughness of other celestial bodies. [less ▲]

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See detailA New Wavelet-Based Mode Decomposition for Oscillating Signals and Comparison with the Empirical Mode Decomposition
Deliège, Adrien ULg; Nicolay, Samuel ULg

in Information Technology: New Generations (2016, April)

We introduce a new method based on wavelets (EWMD) for decomposing a signal into quasi-periodic oscillating components with smooth time-varying amplitudes. This method is inspired by both the “classic” ... [more ▼]

We introduce a new method based on wavelets (EWMD) for decomposing a signal into quasi-periodic oscillating components with smooth time-varying amplitudes. This method is inspired by both the “classic” wavelet-based decomposition and the empirical mode decomposition (EMD). We compare the reconstruction skills and the period detection ability of the method with the well-established EMD on toys examples and the ENSO climate index. It appears that the EWMD accurately decomposes and reconstructs a given signal (with the same efficiency as the EMD), it is better at detecting prescribed periods and is less sensitive to noise. This work provides the first version of the EWMD. Even though there is still room for improvement, it turns out that preliminary results are highly promising. [less ▲]

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See detailReview on the applications of directional impulse responses in room acoustics
Embrechts, Jean-Jacques ULg

in Actes du CFA 2016 (2016, April)

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See detailAge-standardized quality of life after hip or knee arthoplasty.
Neuprez, Audrey ULg; KURTH, William ULg; THIRION, Thierry ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 541-542

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See detailEfficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Reginster, Jean-Yves ULg

in Osteoporosis International (2016, April), 27(supplement 1), 65

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See detailAntibiotherapy in pet rodents and rabbits: a preliminary analysis of practitioners’ habits
Marlier, Didier ULg

in Proceedings of the European College of Zoological Medicine Symposium (2016, April)

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See detailSafety and well-being: an integrated model predicting safety behaviors
Laurent, Julie ULg; Chmiel, Nik; Hansez, Isabelle ULg

Conference (2016, April)

Since Hofmann, Jacobs and Landy (1995) emphasized the need to consider the influences of socio-organizational factors on safety, several studies have invoked psychological processes in order to interpret ... [more ▼]

Since Hofmann, Jacobs and Landy (1995) emphasized the need to consider the influences of socio-organizational factors on safety, several studies have invoked psychological processes in order to interpret the relationships they identified between such organizational factors and safety outcomes. However, studies measuring effectively such psychological processes are quite scarce. Four distinct psychological processes have been identified as fundamental to predict safety behaviors: cognitive, motivational, instrumental and social exchange processes. Hansez and Chmiel (2010) have applied the job demands resources model (Bakker & Demerouti, 2007) to the safety domain, identifying 3 different safety specific (instrumental) and non-safety specific (cognitive and motivational) psychological processes explaining safety violations. Our main aim is to integrate the four psychological processes, but also in-role and extra-role safety behaviors to the same model. More specifically, we aim at replicating Hansez and Chmiel’s (2010) results on a different sample and integrating safety-specific social process to the model. 1,922 workers (71% response rate) returned a questionnaire including validated scales measuring job demands (work overload and role ambiguity), job resources (job quality, decision latitude and work support), job strain, job engagement, perceived management commitment to safety, routine and situational violations, safety participation and safety citizenship role definitions (SCRDs). Data were analyzed using structural equation modelling and bootstrapping. Results showed that, as expected, our model followed the same patterns as Hansez and Chmiel’s (2010) model, confirming the importance of cognitive-energetical, motivational and instrumental processes in the prediction of safety violations. Moreover, perceiving management as committed to safety leads workers to define discretionary safety behaviours as part of the job, which is linked to corresponding discretionary behaviours. Participating in such discretionary activities, in turn, leads to (1) lower situational violations, but also to (2) lower routine violations. These results confirm the importance of safety-specific social exchange processes in the prediction of safety violations. Thus, it appears that different processes of reaction to working conditions can impact employee’ safety behaviors. On the one hand, situational violations are impacted by motivational process, as job resources encourage employees to be stimulated by their job, by instrumental process, as perceiving management as committed to safety is directly associated with lower situational violations, and by social process stemming from job resources (i.e. job resources allow employees to perceive their management as committed to safety, and they reciprocate this interest by defining safety as a part of their role, what encourage them to participate to discretionary safety activities). On the other hand, routine violations are impacted by the same social exchange (although to a lesser extent) and motivational processes, but also by cognitive process, as demanding working conditions may provoke job strain, associated with more “corner-cutting”. A practical implication for companies who want to reduce safety violations is to consider safety-specific and non-safety specific processes together. That is, they can try to improve working conditions considered as job resources, but need to keep in mind that these resources determine more complex safety-specific social exchange processes, through the crucial influence of management. [less ▲]

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See detailMuscular and functional tridimensional analysis after hamstring strain
Paulus, Julien ULg; DELVAUX, François ULg; Schwartz, Cédric ULg et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(2), 263

Introduction The muscle injury, and more especially the hamstring strain, account for a large proportion of explosive top athletes injuries [1-3]. The subsequent down-time period has some sports and ... [more ▼]

Introduction The muscle injury, and more especially the hamstring strain, account for a large proportion of explosive top athletes injuries [1-3]. The subsequent down-time period has some sports and financial negatives consequences for the athlete, his team and/or his club [4, 5]. Despite the rehabilitation before return to play and prevention program, hamstring reinjury rates are still high (26% of all injuries) [6] and it's commonly accepted that a second injury is more severe than a first episode [2]. A more functional test could help the clinician in the return to play process decision to reduce the muscle injuries hamstring relapse. Purpose The aim of our methodology is to analyze, after medical clearance to resume sports activities, for athletes who suffered from grade II/III hamstring muscle strain, the biomechanics of the lower limbs during an explosive jump task. Method After (7,3±0,7 weeks) a grade II or III hamstring muscle tear, eight men (25±5,9 years), without past lower limb major injury, performed: - an isokinetic test (knee maximal flexion-extension in concentric at 60°.s-1 and 240°.s-1 and knee maximal flexion in eccentric at 30°.s-1); - a tridimensional biomechanics analysis of (bipodal and unipodal) squat jump and counter movement jump with Codamotion® system and Kistler® multicomponent force plates. Results A muscular lateral strength imbalance (±10% with p-value < 0,02) has been identified on the hamstring in concentric and eccentric by means of isokinetic testing, with the healthy side stronger than the pathologic. The main statistical significant outcome in the biomechanics analysis is the lower knee angle (±12% with p-value < 0,02) at the low point before the concentric pushing phase of the unipodal CMJ for the healthy leg than to the other one whereas there's no difference between both legs in an equivalent healthy population. Discussion & conclusion The tridimensional analysis appears to be complementary, not redundant, with the isokinetic strength testing due to the different nature of their informations obtained. It could be integrated in the return to play process decision expected the potentially interesting information about the player's biomechanics that it provides. References 1. Ekstrand, J., M. Hagglund, and M. Walden, Epidemiology of muscle injuries in professional football (soccer). Am J Sports Med, 2011. 39(6): p. 1226-32. 2. Ekstrand, J., M. Hagglund, and M. Walden, Injury incidence and injury patterns in professional football: the UEFA injury study. Br J Sports Med, 2011. 45(7): p. 553-8. 3. Lopez, V., Jr., et al., Profile of an American amateur rugby union sevens series. Am J Sports Med, 2012. 40(1): p. 179-84. 4. Price, R.J., et al., The Football Association medical research programme: an audit of injuries in academy youth football. Br J Sports Med, 2004. 38(4): p. 466-71. 5. Verrall, G.M., et al., Assessment of player performance following return to sport after hamstring muscle strain injury. J Sci Med Sport, 2006. 9(1-2): p. 87-90. 6. Brooks, J.H., et al., Incidence, risk, and prevention of hamstring muscle injuries in professional rugby union. Am J Sports Med, 2006. 34(8): p. 1297-306. [less ▲]

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See detailIs isokinetic exercise dangerous for the heart?
Le Goff, Caroline ULg; Kaux, Jean-François ULg; Cavalier, Etienne ULg et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(suppl. 1 No. 2), 457

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in ... [more ▼]

INTRODUCTION: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. PURPOSE: Our study aimed to observe the cardiovascular impact (by biological point of view) of maximal intense isokinetic eccentric and concentric protocols performed by a population of sedentary young men. METHOD: Resting (T0) and post-exercise (just after (T1), 3 hours (T2) and 24 hours after the exercise (T3)) blood samples were taken in 2 populations of young sedentary men: 12 subjects (22.5±1.15 yo) for the eccentric protocol and 18 subjects (22.4±2.6 yo) for the concentric protocol. These subjects performed an intense maximal isokinetic exercise of the quadriceps muscles involving 30 knee flexions–extensions for each leg. We evaluated markers of cardiovascular risk (highly sensitive troponin T (hs-TnT), N-Terminal Brain natriuretic peptide (NT-proBNP), myoglobin (MYO)), of inflammation (highly sensitive C-reactive protein (hsCRP)), muscle damage (creatine kinase (CK)) and of oxidative stress (myeloperoxidase (MPO), lipidic peroxides (POXL), reduced (GSH) and oxidised glutathione (GSSG)). Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: All the physiological parameters measured presented statistically significant changes. For the eccentric exercise, no significant modification in cardiac (NT-proBNP, hs-TNT) and inflammation (hsCRP) biomarkers was observed. However, a significant increase for CK (T3), MYO (T2), MPO (T1), POXL (T1), GSSG (T3) and ratio GSH/GSSG (T2-T3) was shown. For the concentric exercise, the results showed significant increases for the CK (T1-T2-T3), MYO (T1-T2), GSH/GSSG (T1). Evolutionary trends were also observed for the following biomarkers: NT-proBNP (T1-T2-T3), MPO (T2), and GSSG (T4). DISCUSSION and CONCLUSIONS: No modification in cardiac biomarkers was observed after the maximal eccentric isokinetic exercise but some variations can be observed for these biomarkers after the concentric exercise. However, these changes do not exceed the reference values in healthy subjects. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. Nevertheless, a significant level of oxidative stress was induced by both exercises. [less ▲]

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See detailGlobal simulation of UV atmospheric emissions on Mars
González-Galindo; López-Valverde; Forget et al

Poster (2016, April)

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See detailBrain-derived neurotrophic factor (BDNF) in normal healthy and hemodialyzed populations.
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; KOVACS, Stéphanie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 512

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See detailUnderground Pumped Storage Hydropower using abandoned open pit mines: influence of groundwater seepage on the system efficiency
Pujades, Estanislao ULg; Bodeux, Sarah ULg; Orban, Philippe ULg et al

Poster (2016, April)

Pumped Storage Hydropower (PSH) plants can be used to manage the production of electrical energy according to the demand. These plants allow storing and generating electricity during low and high demand ... [more ▼]

Pumped Storage Hydropower (PSH) plants can be used to manage the production of electrical energy according to the demand. These plants allow storing and generating electricity during low and high demand energy periods, respectively. Nevertheless, PSH plants require a determined topography because two reservoirs located at different heights are needed. At sites where PSH plants cannot be constructed due to topography requirements (flat regions), Underground Pumped Storage Hydropower (UPSH) plants can be used to adjust the electricity production. These plants consist in two reservoirs, the upper one is located at the surface (or at shallow depth) while the lower one is underground (or deeper). Abandoned open pit mines can be used as lower reservoirs but these are rarely isolated. As a consequence, UPSH plants will interact with surrounding aquifers exchanging groundwater. Groundwater seepage will modify hydraulic head inside the underground reservoir affecting global efficiency of the UPSH plant. The influence on the plant efficiency caused by the interaction between UPSH plants and aquifers will depend on the aquifer parameters, underground reservoir properties and pumping and injection characteristics. The alteration of the efficiency produced by the groundwater exchanges, which has not been previously considered, is now studied numerically. A set of numerical simulations are performed to establish in terms of efficiency the effects of groundwater exchanges and the optimum conditions to locate an UPSH plant. [less ▲]

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See detailTen years of Denosumab (DMAB) treatment in postmenopausal women with osteoporosis. Results from the FREEDOM Extension trial.
Bone, H.G.; Brandi, M.L.; Brown, J.P. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 135-136

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See detailExploring the effect of a second closely-timed infiltration of platelet-rich plasma to treat proximal patellar tendinopathies
Kaux, Jean-François ULg; CROISIER, Jean-Louis ULg; FORTHOMME, Bénédicte ULg et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 54(Suppl. 1 No. 2), 199

Intorduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to ... [more ▼]

Intorduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. Purpose: The aim of this study was to evaluate whether 2 infiltrations of PRP proves more effective than a single treatment. Methods: Twenty patients suffering from chronic jumper’s knee were enrolled into the study and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. Discussion and Conclusion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups at short to mid term. A second closely-timed infiltration of PRP to treat jumper’s knees is not necessary to improve the efficacy of this treatment in the short term. A second infiltration should perhaps be envisaged later, but this remains to be demonstrated. [less ▲]

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See detailIdentification of nonlinear frequency responses and bifurcations from experimental data
Noël, Jean-Philippe ULg; Gourc, Etienne ULg; Grappasonni, Chiara ULg et al

in Actes de CFA/VISHNO 2016 (2016, April)

The objective of the paper is to obtain the frequency response curves of nonlinear mechanical systems from broadband testing. The proposed approach consists in coupling an identification method with a ... [more ▼]

The objective of the paper is to obtain the frequency response curves of nonlinear mechanical systems from broadband testing. The proposed approach consists in coupling an identification method with a continuation method. Specifically, the frequency-domain nonlinear subspace identification (FNSI) method is first used to derive an experimental model of the structure in state-space from broadband measurements. The harmonic balance method coupled with arclength continuation then utilizes this experimental model to compute the frequency response curves of the system. The method is demonstrated using a numerical example. [less ▲]

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See detailA Refined Method for Estimating the Global Hölder Exponent
Nicolay, Samuel ULg; Kreit, Damien

in Latifi, Shahram (Ed.) Information Technology: New Generations (2016, April)

In this paper, we recall basic results we have obtained about generalized Hölder spaces and present a wavelet characterization that holds under more general hypothesis than previously stated. This ... [more ▼]

In this paper, we recall basic results we have obtained about generalized Hölder spaces and present a wavelet characterization that holds under more general hypothesis than previously stated. This theoretical tool gives rise to a method for estimating the global Hölder exponent which seems to be more precise than other wavelet-based approaches. This work should prove helpful for estimating long range correlations. [less ▲]

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See detailThe O2(a1Δ) Venus nightglow intensity: internal versus solar activity control
Soret, Lauriane ULg; Gérard, Jean-Claude ULg

Conference (2016, April)

Introduction: The O2(a1Δg) Venus nightglow emission at 1.27 μm occurs in the atmospheric region governed by the subsolar to antisolar circulation. Several studies showed that the intensity of this ... [more ▼]

Introduction: The O2(a1Δg) Venus nightglow emission at 1.27 μm occurs in the atmospheric region governed by the subsolar to antisolar circulation. Several studies showed that the intensity of this emission is highly variable on a timescale of hours. Here, we study the possible correlation between the solar flux and the O2 infrared emission using VIRTIS-VEx spectral images at 1.27 μm that has been predicted to exist by theVTGCM model calculations by Bougher and Borucki(1994). VIRTIS data: Using the entire VIRTIS-M-IR nadir database, Soret et al. (2014) generated seven statistical maps of the O2(a1Δg) emission, each containing 500 observations. The purpose was to analyze the location of the brightest spot of the emission and its variations over time. Here, we analyze the intensity of the emission over time. Several methods have been used by Soret et al., (2015) to do so (evolution of the emission maximum, evolution of the average intensity, …) Here we present the results of a new analysis using a masking technique to calculate the time evolution of the nightglow brightness. However, none of them follow the same trend over time. Solar flux data: We now focus on solar flux variations in the time of VIRTIS observations (between May 2006 and October 2008), which were collected during a deep solar minimum. We use the SOHO-CELIAS/SEM (Judge et al., 1998) EUV daily average full solar disk fluxes at 1 AU between 0.1 and 50 nm available from the Space Sciences Center of the University of Southern California. EUV0.1–50 daily average fluxes decrease from 2.6 in May 2006 to 1.9 in October 2008 at the Earth. These values have been adapted to Venus by taking into account the distance from the Sun to the planet, but also the shift in date, considering the difference in solar longitude of the two planets. Values at Venus vary from 4.4 to 3.4, which corresponds to a decrease of 10.4% of the solar flux at Venus compared to a complete solar cycle (ranging from 13.5 to 3.9) Comparison of VIRTIS and SEM datasets: The linear correlation coefficient between the solar flux and the intensity peak is found to be 0.62, which expresses the global decreasing trend for both quantities. This coefficient is not higher because internal variations of the two studied variables do not occur simultaneously. More significantly, the correlation coefficient between the solar flux and the averaged intensities is found to be 0.35, meaning that no relation-ship exists between the O2(a1Δg) brightness and the solar activity. Conclusions: Contrary to the VTGCM calculations, we do not observe here a correlation between the O2(a1Δg) brightness and the solar flux. However, VIRTIS data were acquired during a deep solar minimum and, more importantly, during a relatively stable phase of the solar activity. A high level of variability of the O2(a1Δg) emission has been detected in the same dataset from day to day though (Hueso et al., 2008; Soret et al., 2014). It thus appears that the variability is more controlled by internal than external conditions: transport appears to play a major role in the nightglow emissions than the solar activity eventually does. This conclusion is at least valid for solar minimum conditions. A space mission with global imaging capabilities over an entire solar cycle would definitely allow determining the relative role played by solar activity and internal factors. [less ▲]

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See detailTreeNET: Discovering and Connecting Subnets
Grailet, Jean-François ULg; Tarissan, Fabien; Donnet, Benoît ULg

in 8th International Workshop on Traffic Monitoring and Analysis (TMA) (2016, April)

Since the early 2000's, the Internet topology has been an attractive and important research topic, either for developing data collection mechanisms, and for analyzing and modeling the network. Beside ... [more ▼]

Since the early 2000's, the Internet topology has been an attractive and important research topic, either for developing data collection mechanisms, and for analyzing and modeling the network. Beside traditional aspects of the Internet topology (i.e., IP interface, router, and AS levels), recent researches focused on intermediate promising visions of the topology, namely Point-of-Presence (PoP) and subnets (i.e., a set of devices that are located on the same connection medium and that can communicate directly with each other at the link layer). This paper focuses on network subnet discovery by proposing a new tool called treenet. One of the key aspects of treenet is that it builds a tree representing the way subnets are located with respect to each other. This tree allows treenet to obtain additional information on the network, leading to better analysis of the collected data. In this paper, we demonstrate the potential of treenet through the evaluation of its key algorithmic steps and the study of measurements collected from the PlanetLab testbed. [less ▲]

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See detailMise au point d’une nouvelle méthode de diagnostic des allergènes du froment par Western blot 2D
BERTHOLET, Catherine ULg; GADISSEUR, Romy ULg; Quinting, Birgit

in Revue Française d'Allergologie (2016, April), 56(3), 284

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See detailPrevalence of frailty among nursing home, according to different operational definitions.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; GILLAIN, Sophie ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 216-217

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See detailFirst steps of the regional climate model MAR over the Euro-CORDEX domain
Scholzen, Chloé ULg; Fettweis, Xavier ULg

Poster (2016, April)

In the framework of the Euro-CORDEX initiative, the Laboratory of Climatology of the University of Liège, Belgium, is currently using the regional climate model MAR (for “Modèle Atmosphérique Régional” ... [more ▼]

In the framework of the Euro-CORDEX initiative, the Laboratory of Climatology of the University of Liège, Belgium, is currently using the regional climate model MAR (for “Modèle Atmosphérique Régional”) to simulate the past, present and future climate over Europe. Simulations are to be performed for both available resolutions over the Euro-CORDEX domain, namely 0.11 deg. (12.5 km) and 0.44 deg. (50 km). Historical and present-day runs (1979-2015) will use the ERA-Interim and the NCEP/NCAR-v1 reanalyses as boundary conditions, whereas future projections will be driven by two selected GCMs from the CMIP5 database: NorESM1-M and MIROC5. All CMIP5-GCMs were previously compared against ERA-Interim reanalysis data in terms of their ability to represent the current mean climate over Europe. The GCMs also underwent a statistical classification based on the calculation of skill-scores evaluating for instance 850 hPa temperature and 500 hPa geopotential height. Several settings and parameters were tested in order to calibrate the regional climate model MAR over the Euro-CORDEX domain. MAR is to be validated against observations from the European Climate Assessment & Dataset (ECA&D). The final aim of this study is to assess the performance of MAR in comparing its results to other RCMs used within the Euro-CORDEX initiative. [less ▲]

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See detailInfluence of plant roots on electrical resistivity measurements of cultivated soil columns
Maloteau, Sophie ULg; Blanchy, Guillaume ULg; Javaux, Mathieu et al

Poster (2016, April)

The goals of this experiment are to quantify the effect of plant roots on electrical resistivity of the soil subsurface and to map a plant roots system in space and time with ERT technique in a soil ... [more ▼]

The goals of this experiment are to quantify the effect of plant roots on electrical resistivity of the soil subsurface and to map a plant roots system in space and time with ERT technique in a soil column. For this research, it is assumed that roots system affect the electrical properties of the rhizosphere. Indeed the root activity (by transporting ions, releasing exudates, changing the soil structure,…) will modify the rhizosphere electrical conductivity (Lobet G. et al, 2013). This experiment is included in a bigger research project about the influence of roots system on geophysics measurements. Measurements are made on cylinders of 45 cm high and a diameter of 20 cm, filled with saturated loam on which seeds of Brachypodium distachyon (L.) Beauv. are sowed. Columns are equipped with electrodes, TDR probes and temperature sensors. Experiments are conducted at Gembloux Agro-Bio Tech, in a growing chamber with controlled conditions: temperature of the air is fixed to 20°C, photoperiod is equal to 14 hours, photosynthetically active radiation is equal to 200 µmol m-2s-1, and air relative humidity is fixed to 80 %. Columns are fully saturated the first day of the measurements duration then no more irrigation is done till the end of the experiment. [less ▲]

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See detailPhysical and muscle performances among elderly nursing home residents.
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Croisier, Jean-Louis ULg et al

in Osteoporosis International (2016, April), 27(Supplement 1), 217

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See detailEfficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Rannou, F.; Maheu; Reginster, Jean-Yves ULg

in Osteoporosis International (2016, April), 27(supplement 1), 66

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See detailPrevalence of concomitant bone and muscle wasting in patients from the SarcoPhAge study.
Locquet, Médéa ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in Osteoporosis International (2016, April), 27(supplement 1), 129

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See detailAnodal transcranial direct stimulation (tDCS) targeting the anterior cingulate gyrus for the preventive treatment of chronic cluster headache: a proof of concept trial.
MAGIS, Delphine ULg; D'Ostilio, Kevin ULg; Cosseddu, Anna et al

Poster (2016, April)

Background There is a need for better treatments in chronic cluster headache (CCH). In responders to percutaneous occipital nerve stimulation, the subgenual anterior cingulate gyrus (sACG) was found ... [more ▼]

Background There is a need for better treatments in chronic cluster headache (CCH). In responders to percutaneous occipital nerve stimulation, the subgenual anterior cingulate gyrus (sACG) was found hypermetabolic (Magis et al. 2011). We reasoned that activation of this area by transcranial neurostimulation could be effective in CCH. Aim To explore the preventive effect of anodal (i.e. activating) transcranial direct current stimulation (tDCS) targeting the anterior cingulate gyrus in CCH patients. Method & subjects Difficult-to-treat CCH patients with a stable preventive drug regimen applied tDCS (2mA) interictally in 20-minute daily sessions for 4 weeks with the anode positioned over the forehead (FpZ), the cathode over the C7 spinous process. Therapeutic effects were monitored with paper diaries. Results Nineteen patients were enrolled up to now. In 13 patients who completed the trial, mean weekly attack frequency decreased by 38% after 4 weeks of daily stimulation (W-test: p = 0.002). The 50% responder rate was 54%. Patients (n=12) reported an improvement in headache impact, as shown by 5-point decrease in the mean HIT-6 score (from 67 to 62, p = 0.02). In 10 patients who were followed up after the treatment period, the benefit remained stable up to 4 weeks after the last stimulation. The first 3 enrolled patients had superficial skin burns under the adhesive cathode electrode. Sponge electrodes were therefore used in all subsequent patients without any adverse effect. Conclusion Anodal tDCS targeting the anterior cingulate gyrus seems promising for the preventive treatment of chronic cluster headache as suggested by this ongoing proof-of-concept trial. Use of adhesive electrodes is not recommended. [less ▲]

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See detailOsteoarthritic sclerotic subchondral osteoblasts secreted elevated concentration of fibulin-3 fragments in vitro
Sanchez, Christelle ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 83

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See detailA nonlinear state-space solution to a hysteretic benchmark in system identification
Noël, Jean-Philippe ULg; Esfahani, Alireza; Kerschen, Gaëtan ULg et al

Conference (2016, April)

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See detailNon-invasive vagus nerve stimulation with the gammaCore® in healthy subjects: is there electrophysiological evidence for activation of vagal afferents ?
Schoenen, Jean ULg; NONIS, Romain ULg; D'Ostilio, Kevin ULg et al

Poster (2016, April)

Abstract: Background Non-invasive vagus nerve stimulation (nVNS) with the gammaCore® improves migraine and cluster headache. Animal experiments suggest that nVNS acts via stimulation of vagal afferents ... [more ▼]

Abstract: Background Non-invasive vagus nerve stimulation (nVNS) with the gammaCore® improves migraine and cluster headache. Animal experiments suggest that nVNS acts via stimulation of vagal afferents, but proof in humans is lacking. Vagal somatosensory evoked potentials (vSEP) are identified after invasive VNS or transcutaneous stimulation of auricular vagal branches, but late components could be muscle artifacts. Objective To search in healthy volunteers for reliable vSEP during nVNS with the gammaCore® Methods In 12 healthy subjects (7males) evoked potentials were recorded at A1/A2 (ref Cz) and C3/C4 (ref F3/F4) during 2-minute stimulation over left/right cervical vagus nerve with the gammaCore® (25Hz, 6-24V) and during stimulation over the inner tragus with a monopolar stimulator (2Hz, 50 stimuli, mean intensity 8mA). Results We identified 3 reproducible peaks P1, N1, P2 in 10 patients on the side of the gammaCore® stimulation at mean latencies of 2.05ms, 5.20ms and 9.13ms. P1-N1 amplitude increased significantly (p<0.01) with increasing voltage from 0.04μV to 0.52μV (C3/C4) and from 0.13µV to 2.04μV (A1/A2) respectively at 10V and 30V. Inner tragus stimulation elicited P1, N1, P2 peaks with shorter mean latencies (2.21ms, 3.72ms, 5.71ms) and a mean P1-N1 amplitude (A1/A2) of 5.0µV. When the gammaCore® was placed over the sternocleidomastoid muscle, there were no reproducible evoked potentials. Conclusion Non-invasive transcutaneous stimulation of the cervical vagus nerve with the gammaCore® elicits evoked potentials similar to those found with implanted electrodes or stimulation of Arnold’s nerve in the outer ear. The gammaCore®-evoked potentials increase in amplitude with stimulation intensity and disappear when the stimulator is positioned over neck muscles, suggesting that they are not muscle artifacts. Their short latency is compatible with their generation at the level of the foramen jugulare. The therapeutic effects reported with the gammaCore® in primary headaches can thus be mediated by genuine activation of vagus nerve afferents. [less ▲]

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See detailEnglish translation and cross-cultural adaptation of the SarQuoL® questionnaire.
Beaudart, Charlotte ULg; Edwards, M.; Dennison, E.M. et al

in Osteoporosis International (2016, April), 27(Supplement 1), 221-222

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See detailEffectiveness of High Intensity Radial Shock Wave Therapy in The Treatment of Chronic Plantar Fasciitis
Demoulin, Christophe ULg; Vanderthommen, Marc ULg; Fromm, Aurélien et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 52(Suppl. 1 No. 2), 733

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain ... [more ▼]

Introduction: Literature is scarce concerning the effectiveness of high dose radial extracorporeal shock wave therapy (ESWT). Therefore, the aim of this study was to investigate its effectiveness on pain, function and pressure pain threshold in patients with chronicplantar fasciitis (PF). Materials and Methods: Patients with a diagnosis of chronic (pain lasting for more than 3 months) uni- or bilateral PF with a history of failed conservative treatment were included. After a 6-week control period during which no treatment occurred, a 2-week treatment period followed by a three weeks of rest (cicatrization phase) was provided. The treatment period consisted of three radial ESWT sessions (2000 impulses of 10 Hz frequency per session with an energy flux density of 0,275mJ/mm2) separated by a one-weekinterval. Patient assessments (pain intensity, foot function and pressure pain threshold (PPT) at the site of maximum local tenderness disability) were conducted at baseline, after the 6-week control phase (pre-treatment) and at the end of the cicatrization phase (post-treatment). Results: Thirty patients (19 women (63.3%)) with chronic PF and a mean age of 51.9±11 years were included in the present study. No drop-out occurred throughout the study period. No changes were observed at the pre-treatment assessment session except for pain intensity which decreased slightly but significantly (P<0.05). At the post-treatment session, highly significant (P<0.001) and clinically meaningful changes occurred for pain intensity (-34%), foot function score (-60%) and PPT (+68%). Conclusions: The present study suggests that high dose radial ESWT is a feasible and effective way to quickly and significantly decrease pain and disability in most patients with chronic PF. [less ▲]

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See detailUncertainty quantification in profile Hidden Markov Models (pHMM)-based activity sequences characterization
Saadi, Ismaïl ULg; Liu, Feng; El Saeid Mustafa, Ahmed Mohamed ULg et al

Poster (2016, April)

Recently, Liu et al. (2015) proposed a method to characterize activity sequences stemming from activity-travel diaries. The framework is structured as follows: from an extracted set of activity sequences ... [more ▼]

Recently, Liu et al. (2015) proposed a method to characterize activity sequences stemming from activity-travel diaries. The framework is structured as follows: from an extracted set of activity sequences, (a) the occurrence probabilities of the different activities are determined as well as their sequential order for aligning the activity sequences. Then, (b) profile Hidden Markov Models (pHMM) are defined based on the previous output. This technique is interesting given the fact that it is also able to include the irregular activities and, as a result, their derived trips. In this context, thinking about integration with an agent-based micro-simulation model requires, as a preliminary step, an uncertainty quantification analysis in order to measure the variability of the outcome. This approach is all the more necessary when agent-based micro-simulation is used to predict mid- and long-term system states. [less ▲]

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See detailAlpha-synuclein as biomarker in Parkinson’s disease: strategies for detection in CGE-LIF
Houbart, Virginie ULg; Napp, Aurore ULg; Rudaz, Serge et al

Poster (2016, April)

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

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See detailCompact handheld low-cost biosensor platform for remote health monitoring
Hastanin, Juriy ULg; Lenaerts, Cedric ULg; Gailly, Patrick ULg et al

in Proceedings of SPIE; SPIE 2016 Photonics Europe (2016, April)

In this paper, we present an original concept of plasmonic-related instrumentation platform dedicated to diagnostic biosensing tests out of the laboratory. The developed instrumental platform includes ... [more ▼]

In this paper, we present an original concept of plasmonic-related instrumentation platform dedicated to diagnostic biosensing tests out of the laboratory. The developed instrumental platform includes both disposable one-use microfluidic affinity biochip and compact optical readout device for biochip monitoring involving mobile Internet devices for data processing and communication. The biochip includes both microfluidic and optical coupling structures formed into a single plastic slab. The microfluidic path of the biochip operates in passive capillary pumping mode. In the proof-of-concept prototype, we address specifically the sensing format involving Surface Plasmon Resonance phenomenon. The biochip is plugged in the readout device without the use of an index matching fluid. An essential advantage of the developed biochip is that its implementation involves conventional hot embossing and thin film deposition process, perfectly suited for mass production of low-cost microfluidic biochip for biochemical applications. [less ▲]

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See detailContribution of future urbanisation expansion to flood risk changes
Bruwier, Martin ULg; Mustafa, Ahmed; Archambeau, Pierre ULg et al

Conference (2016, April)

The flood risk is expected to increase in the future due to climate change and urban development. Climate change modifies flood hazard and urban development influences exposure and vulnerability to floods ... [more ▼]

The flood risk is expected to increase in the future due to climate change and urban development. Climate change modifies flood hazard and urban development influences exposure and vulnerability to floods. While the influence of climate change on flood risk has been studied widely, the impact of urban development also needs to be considered in a sustainable flood risk management approach. The main goal of this study is the determination of the sensitivity of future flood risk to different urban devel~ opment scenarios at a relatively short-time horizon in the River Meuse basin in Wallonia (Belgium). From the different scenarios, the expected impact of urban development on flood risk is assessed. Three urban expansion scenarios are developed up to 2030 based on a coupled cellular automata (CA) and agent-based (AB) urban expansion model: (i) business-as-usual, (ii) restrictive and (m) extreme expansion scenarios. The main factor controlling these scenarios is the future urban land demand. Each urban expansion scenario is developed by considering or not high and/or medium flood hazard zones as a constraint for urban development. To assess the model's performance, it is calibrated for the Meuse River valley (Belgium) to simulate urban expansion between i990 and 2000. Calibration results are then assessed by comparing the 2000 simulated land-use map and the actual 2000 land-use map. The flood damage estimation for each urban expansion scenario is determined for five flood discharges by overlaying the inundation map resulting from a hydraulic computation and tlte urban expansion map and by using damage curves and specific prices. The hydraulic model Wolt‘2D has been extensively validated by comparisons between observations and computational results during flood event .This study focuses only on mobile and immobile prices for urban lands, which are associated to the most severe damages caused by floods along the River Meuse. These findings of this study offers tools to drive urban expansion based on numerous policies visions to mitigate future flood risk along the Meuse River. In particular, we assess the impacts on future flood risk of the prohibition of urban development in high and/or medium flood hazard zones. [less ▲]

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See detailContrasting Arctic and Antarctic sea ice temperatures
Vancoppenolle, M.; Raphael, M.; Rousset, C. et al

Conference (2016, April)

Sea ice temperature affects the sea ice growth rate, heat content, permeability and habitability for ice algae. Large-scale simulations with NEMO-LIM suggest large ice temperature contrasts between the ... [more ▼]

Sea ice temperature affects the sea ice growth rate, heat content, permeability and habitability for ice algae. Large-scale simulations with NEMO-LIM suggest large ice temperature contrasts between the Arctic and the Antarctic sea ice. First, Antarctic sea ice proves generally warmer than in the Arctic, in particular during winter, where differences reach up to ∼10◦C. Second, the seasonality of temperature is different among the two hemispheres: Antarctic ice temperatures are 2-3◦C higher in spring than they are in fall, whereas the opposite is true in the Arctic. These two key differences are supported by the available ice core and mass balance buoys temperature observations, and can be attributed to differences in air temperature and snow depth. As a result, the ice is found to be habitable and permeable over much larger areas and much earlier in late spring in the Antarctic as compared with the Arctic, which consequences on biogeochemical exchanges in the sea ice zone remain to be evaluated. [less ▲]

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See detailUsing a polynomial decoupling algorithm for state-space identification of a Bouc-Wen system
Esfahani, Alireza; Dreesen, Philippe; Tiels, Koen et al

Conference (2016, April)

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See detailVoyage d'étude curriculum et évaluation de la qualité
Pirard, Florence ULg; Goossens, Xavier

Conference (2016, March 25)

Quand ils sont inscrits dans des dispositifs d’accompagnement organisé en réseau et ancré dans les pratiques professionnelles, on peut faire l’hypothèse que les voyages d’étude contribuent à une ... [more ▼]

Quand ils sont inscrits dans des dispositifs d’accompagnement organisé en réseau et ancré dans les pratiques professionnelles, on peut faire l’hypothèse que les voyages d’étude contribuent à une transformation à la fois des acteurs qui découvrent d’autres manières de penser et d’agir et des actions qu’ils sont susceptibles d’améliorer. Ils s’inscrivent dans des dispositifs qui relèvent d’une culture de la professionnalisation. Nous analyserons un dispositif d’accompagnement centré sur le travail avec les familles qui intègre des voyages d’étude pour des professionnel-le-s de l’accueil en collectivité (fonction d’accueil, direction et coordination). Elle questionne la place du voyage d’étude dans le dispositif, les conditions de sa mise en œuvre et les effets observés sur les pratiques professionnelles. [less ▲]

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See detailUne généralisation du triangle de Pascal et la suite A007306
Stipulanti, Manon ULg

Conference (2016, March 25)

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word ... [more ▼]

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word. Similarly to the Sierpinski gasket that can be built as the limit set, for the Hausdorff distance, of a convergent sequence of normalized compact blocks extracted from Pascal triangle modulo 2, we describe and study the first properties of the subset of [0, 1]×[0, 1] associated with this extended Pascal triangle modulo a prime p. We consider a sequence (S(n))n≥0 counting the number of positive entries on each row of the generalized Pascal triangle. By introducing a convenient tree structure, we provide a recurrence relation for (S(n))n≥0, we prove that the sequence is 2-regular, give a linear representation and make the connection with the sequence of denominators occurring in the Farey tree. [less ▲]

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See detailrapport de mission colloque Rencontres Waterloo Paris 24-25 mars 2016
Raxhon, Philippe ULg

Poster (2016, March 24)

Présence mémorielle de la bataille de Waterloo au cours de la Première Guerre mondiale, dans le contexte du centenaire de l'événement en 1915.

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See detailAnalyse qualitative et quantitative des populations de norovirus murins générées lors d’infections in vitro synchrones et asynchrones avec des souches homologues : détection de phénomènes de dominance, d’interférence due aux particules non-infectieuses et d’exclusion à la surinfection
Di Felice, Elisabetta; Ludwig, Louisa ULg; Toffoli, Barbara et al

Poster (2016, March 24)

RÉSUMÉ Buts du travail La recombinaison est un des mécanismes moteurs de l’évolution génétique des norovirus. Malgré une détection fréquente de séquences recombinantes à partir d’échantillons de terrain ... [more ▼]

RÉSUMÉ Buts du travail La recombinaison est un des mécanismes moteurs de l’évolution génétique des norovirus. Malgré une détection fréquente de séquences recombinantes à partir d’échantillons de terrain, la reproduction du phénomène de recombinaison en conditions de laboratoire semble difficile. Utilisant le modèle du norovirus murin, cette étude a pour objectif d’évaluer de manière qualitative et quantitative les populations virales, y compris potentiellement recombinantes, générées lors de variations des conditions de temps et de multiplicité d’infection dans des expériences de coinfections ou de surinfections in vitro. Méthodes Des cellules RAW264.7 ont été inoculées par deux souches homologues de norovirus murins (infection primaire : Wu20 ; surinfection : CW1) en utilisant des multiplicités d’infection (MOI : Wu20 = 1; CW1= 0.1, 1 ou 10) et des temps d’inoculation (surinfection après un délai allant de 0 minutes à 24 heures) variables. Les surnageants ont été prélevés 24h post-surinfection et une quantification moléculaire discriminante sur la région 5’ du génome a été réalisée. Des cellules ont été ré-inoculées par ces surnageants et 36 isolats ont été amplifiés. Ces isolats ont été caractérisés moléculairement comme de type CW1, Wu20 ou recombinant par une méthode discriminante sur leurs extrémités génomiques 3’ et 5’. Les recombinants potentiels ont été séquencés sur la région génomique classiquement impliquée dans la recombinaison (chevauchement ORF 1/2). Résultats et discussion L’analyse des ratios des isolats a montré une tendance à une dominance potentielle de Wu20 sur CW1 pour les conditions de MOI relatives 0.1/1 et 1/1 avec un phénomène d’exclusion à la surinfection entre les temps t4 (4h post-infection primaire) et t8. Cependant, cette tendance n’a pas été détectée dans la condition de MOI relative 10/1. Ceci suggère une hypothèse de présence de particules défectives interférentes (PDI) dans la population de Wu20 qui pourrait interférer avec les étapes précoces de l’attachement et de l’entrée et donc modifier les ratios attendus 24h post-infection. La comparaison des ratios de copies génomiques a soutenu l’hypothèse de présence de PDI dans la population de Wu20 avec des ratios différents de ceux logiquement escomptés aux MOI relatives 0.1/1 et 1/1, et qui se sont vérifiés cette fois en condition 10/1 (condition dans laquelle CW1 peut retrouver une chance réelle dans la compétition à l’attachement et à la pénétration). Cependant le temps t1 de cette condition a dévié clairement de la tendance générale et pourrait constituer une population virale de choix pour la présence de recombinants ou suggérer un autre mécanisme par lequel CW1 pourrait momentanément être dominant par rapport à Wu20. L’exclusion à la surinfection a également pu être corroborée par l’analyse moléculaire quantitative. Trois isolats ont été détectés comme des recombinants potentiels mais les séquençages n’ont pu les confirmer. Les évènements de recombinaison pourraient avoir eu lieu sur une autre région que celle classiquement décrite. Cette étude permet de montrer que la composition de la population virale peut avoir un effet majeur sur la compétition entre deux norovirus. Elle suggère également l’existence d’un mécanisme d’exclusion à la surinfection. Elle confirme enfin que malgré les fréquentes détections de souches recombinantes in silico, le phénomène de recombinaison est difficile à reproduire in vitro chez les norovirus. [less ▲]

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See detailThe mysteries of droplet birth in microfluidic cross junctions
Van Loo, Stéphanie ULg; Gilet, Tristan ULg

Poster (2016, March 24)

In microfluidics, flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. We here present an experimental study of droplet formation in a microfluidic cross ... [more ▼]

In microfluidics, flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. We here present an experimental study of droplet formation in a microfluidic cross-junction with a minimum number of geometrical parameters. We mostly focus on the dripping regime. The dynamics of droplet formation is composed of two distinct steps : filling and pinching. The duration of each step (and cor- responding volumes of each phase) are analyzed. They vary according to both water and oil flow rates. These variations reveal several insights about the fluid flows in both phases. We propose some scaling laws to relate the droplet volume and frequency to the flow rate of both phases. We also discuss the influence of surfactant on droplet formation. [less ▲]

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See detailCalendars and rituals at Mari during the šakkanakkū period (end of the 3rd millennium B.C. – beginning of the 2nd)
Colonna d'Istria, Laurent ULg

Conference (2016, March 23)

The order of the months in the calendar at the end of the šakkanakkū period (19th century B.C.) is now well established. This calendar is largely similar to the one in use during the amorite period. This ... [more ▼]

The order of the months in the calendar at the end of the šakkanakkū period (19th century B.C.) is now well established. This calendar is largely similar to the one in use during the amorite period. This paper will focus on the rituals and festivals at Mari during the end of the šakkanakkū period: expenditures for temples, deities and rituals are mentioned in many administrative texts dated to the mid-19th century. Nevertheless, these texts are very patchy and the festivals are not clearly named. The latest excavation archaeological excavations at the site of Tell Hariri-Mari provided us with eleven administrative texts dated to the middle of the šakkanakkū period (i.e. UrIII period or slightly earlier). These texts reveal a calendar which is partly similar to the late šakkanakkū one. [less ▲]

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See detailRefractory ceramic molds fabrication by additive methods for low and high melting point metal alloys casting
Bister, Geoffroy; Deschuyteneer, Dorian; Hautcoeur, Dominique et al

Conference (2016, March 23)

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See detailEtude de dermatophytes isolés dans les services de revalidation et physiothérapie d’une structure hospitalière en région Liégeoise (Belgique)
SACHELI, Rosalie ULg; Utri, Tania ULg; Abdel-Sadick, Hidjab Abdoulaye ULg et al

Poster (2016, March 23)

Objectifs : Les dermatophytes sont responsables d’infections de la peau, des ongles et du cuir chevelu. Les espèces anthropophiles peuvent se transmettre d’une personne à une autre par un simple contact ... [more ▼]

Objectifs : Les dermatophytes sont responsables d’infections de la peau, des ongles et du cuir chevelu. Les espèces anthropophiles peuvent se transmettre d’une personne à une autre par un simple contact. Leur présence en milieu sportif (salles de sport, piscine, tatamis), douches collectives, vestiaires des écoles, a été largement décrite. Par contre il existe peu de littérature concernant les établissements de soins. C’est pourquoi, nous nous sommes intéressés au risque potentiel d’infection par des dermatophytes en milieu hospitalier et particulièrement dans les salles de kinésithérapie et de revalidation ainsi que dans une piscine du CHU de Liège. Matériel et méthodes : Trois sites du CHU de Liège ont été investigués: le site du Sart Tilman (ST), le site Ourthe Amblève (OA) et le site Notre-Dame des Bruyères (NDB). Les prélèvements ont été effectués en salle de revalidation et kinésithérapie ainsi qu’à la piscine de revalidation. Ces prélèvements ont été réalisés sur les surfaces à l’aide de géloses de contact (milieu de Sabouraud/chloramphénicol/actidione/gentamicine, Tritium Microbiologie, Pays-bas). L’identification des espèces fongiques a été réalisée par observation macro-microscopique des cultures, spectrométrie de masse (Maldi-Tof) et séquençage moléculaire. Résultats : Au total, 552 prélèvements ont été réalisés parmi lesquels 15 dermatophytes ont été recensés (2,72%). On retrouve: 7 T. rubrum, 7 T. interdigitale, 1 T. mentagrophytes var. mentagrophytes. Sur le site ST, 207 prélèvements ont été effectués parmi lesquels 4 T. rubrum, 1 T. interdigitale et 1 T. mentagrophytes var. mentagrophytes (zoophile). Sur le site OA, parmi les 226 prélèvements effectués, 4 Trichophyton interdigitale et 3 Trichophyton rubrum ont été retrouvés. Aucun dermatophyte n’a été isolé de l’eau de piscine ou pédiluve. Sur le site de NDB, sur 119 prélèvements, seuls 2 isolats de Trichophyton interdigitale ont été identifiés. Les prélèvements positifs pour les dermatophytes concernent des tapis de gymnastique, vélos, rameurs, balances, trampolines, demi-sphères d’équilibre, table de kinésithérapie, sols de douches et vestiaires de la piscine. Conclusion Grâce à ces investigations, nous avons pu mettre en évidence sur le matériel de revalidation et les sols des vestiaires, la présence de deux espèces anthropophiles, T. rubrum et T. interdigitale fréquemment impliquées dans les cas d’onychomycoses et atteintes cutanées. Une souche zoophile de T. mentagrophytes a également été mise en évidence. Cette étude démontre qu’un renforcement de la fréquence de nettoyage des sols et des instruments utilisés dans les salles de sport du CHU de Liège est nécessaire de façon à minimaliser les risques de contamination de patients et du personnel médical. [less ▲]

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See detailWavelet-based Methods to Study the Regularity of a Signal: from Theory to Practice
Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

Conference (2016, March 23)

In this talk, I use the notion of wavelet to design multifractal formalisms. I present the theoritical results obtained on the generalized Snu spaces and I show the utility of these generalization ... [more ▼]

In this talk, I use the notion of wavelet to design multifractal formalisms. I present the theoritical results obtained on the generalized Snu spaces and I show the utility of these generalization. Besides, I also apply these formalisms on a practical example: the Mars topography. [less ▲]

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See detailOsteopontin predicts radiotherapy response of glioblastoma patients : new role in DNA damage repair
Henry, Aurélie ULg; Nokin, Marie-Julie; Leroi, Natacha ULg et al

Conference (2016, March 22)

- Introduction: Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These ... [more ▼]

- Introduction: Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These treatments include maximal surgical resection, radiotherapy and concomitant or adjuvant chemotherapy with Temozolomide. However, the prognosis of adult patients with GBM remains poor and the survival outcome after treatment does not exceed 15 months. GBM-composing cells have developed many strategies to counteract these current therapies. Among the wide hallmarks acquired to survive, high osteopontin (OPN) expression correlates with lower overall and disease-free/relapse-free survival in all tumors combined, as well in brain cancer. Our recent study (Lamour V and Henry A, IJC 2015) has demonstrated the role of OPN in the tumorigenicity of glioblastoma cells and its importance in the maintenance of the stem characters. In the continuation of this work, our recent studies focused on the potential role of OPN in the resistance of GBM cells to radiotherapy and its potential implication in the initiation of Double Strand Breaks (DSBs) repair mechanisms. - Aims: In the context of this study, different GBM cell lines (U251-MG, U87-MG and U87 Viii) were used to assess the role of OPN in the initiation of the DSBs repair mechanism after an exposure to gamma-irradiation. - Methods and results: We performed the transient transfection of different GBM cell lines (U251-MG, U87-MG and U87-MG overexpressing EGFR VIII) with siRNAs specifically directed against OPN. After irradiation, all these OPN-depleted cells consistently showed a lower induction of γ–H2AX compared to control (irrelevant siRNA) as evidenced by western blot and immunofluorescence techniques. Thereafter, clonogenic assays allowed to prove that the survival of OPN-depleted cells was affected after an exposure to irradiation. To assess the importance of OPN expression in the response to radiotherapy, an heterotopic xenograft model was used. In brief, IPTG-inducible U87 shOPN clones were injected subcutaneously in NOD-SCID mice and were allowed to form a tumor. When average tumor volume reached a predetermined size range, mice were treated (or not) with IPTG by intraperitoneal injection during five days. At the end of the treatment, tumors were selectively exposed to gamma-irradiation by using a small animal irradiator X-RAD 225Cx (Precision X-Ray Inc., North Branford, CT). One week later, mice were sacrificed and tumors were measured. In this pilot study, we observed that mice in which the tumor was depleted in OPN displayed a slight regression in the tumor growth compared to mice that received radiotherapy alone (no IPTG), where the tumor volume remained constant. - Conclusions: Taken together, these preliminary data meet the fact that OPN is important in the response of GBM to radiotherapy. The in vitro results converge to the fact that OPN might be implicated in the initiation of the DSBs repair following irradiation. Currently, we would like to investigate this hypothesis in vivo but also to check the effect of OPN depletion combined to radiotherapy on the survival of mice in an orthotopic xenograft model. [less ▲]

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See detailEFFECT OF EXTRACTION pH ON PHYSICO-CHEMICAL, ENZYMATIC AND TECHNOLOGICAL PROPERTIES OF CRUDE EXTRACTS FROM WILD CARDOON (CYNARA CARDUNCULUS L.) FLOWERS
BEN AMIRA, Amal; BESBES, Souhail; ATTIA, Hamadi et al

Conference (2016, March 22)

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See detailThe use of protein-polysaccharide complexes to enhance protein delivery in CaCO3 microparticles
Ramalapa, Bathabile ULg; Crasson, Oscar ULg; Vandevenne, Marylène ULg et al

Conference (2016, March 22)

The role of protein therapeutics in modern medicine has increased considerably due to their potential to perform complex functions in the body that cannot be mimicked by simple chemical compounds. To ... [more ▼]

The role of protein therapeutics in modern medicine has increased considerably due to their potential to perform complex functions in the body that cannot be mimicked by simple chemical compounds. To increase the safety, stability and efficacy of protein therapeutics; there exists a need for delivery systems that are biocompatible, prevent premature degradation of bioactives and allow targeted delivery and controlled release. Calcium carbonate (CaCO3) has gained great favour for employment in protein delivery due to possibilities of controlling size, morphology and crystalline forms of particles by tuning the synthesis conditions. The aim of the present work was to assess the significance of polysaccharide-protein complexes in enhancing the encapsulation of proteins in CaCO3 microspheres. A Chitin Binding Domain (ChBD), reported to have affinity for hyaluronic acid, was inserted on β-lactamase enzyme to develop a chimeric protein. The chimeric protein retained the activity of the enzyme and the binding properties and was encapsulated in CaCO3 microspheres by a super critical CO2 (ScCO2) process using hyaluronic acid as a templating agent. The particles were characterised in terms of size, zeta potential, morphology and protein loading. The results obtained confirmed the affinity of the ChBD to hyaluronic acid towards the production of stable, vaterite microparticles. Protein assays demonstrated that the ChBD enhanced the encapsulation of protein by up to 10 fold. Confocal images also suggested high encapsulation of the chimeric protein compared to native protein. Thus the production of polysaccharide-protein complexes seems effective in enhancing the encapsulation of proteins in CaCO3 microparticles using the ScCO2 process. [less ▲]

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See detailTHERAPEUTIC EFFECT ANTIOXIDANT OF EGCG EXTRACT OF GREEN TEA POLYPHENOLS
AMROUCHE, Zoheir; ELHADI, Djamel; BITAM, Arezki et al

Conference (2016, March 22)

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See detailFeasibility study of repetitive diffusion MRI after Neoadjuvant radiotherapy for following tumor microenvironment.
LALLEMAND, François ULg; Leroi, Natacha ULg; Bahri, Mohamed Ali ULg et al

Conference (2016, March 22)

Purpose/Objective. Neoadjuvant radiotherapy (NeoRT) improves tumor local control and tumor resection in many cancers. The timing between the end of the NeoRT and surgery is mostly driven by the occurrence ... [more ▼]

Purpose/Objective. Neoadjuvant radiotherapy (NeoRT) improves tumor local control and tumor resection in many cancers. The timing between the end of the NeoRT and surgery is mostly driven by the occurrence of side effects or the tumor downsizing. We previously demonstrated in an in vivo model that the timing of surgery and the schedule of NeoRT influenced the tumor dissemination. Here, our aim is to evaluate with functional MRI (fMRI) the impact of the radiation treatment on the tumor microenvironment and subsequently to identify non-invasive markers helping to determine the best timing to perform surgery for avoiding tumor spreading. First, we needed to demonstrate the feasibility of repetitive MRI imaging after NeoRT in mice. Material/methods. We used two models of NeoRT we previously developed in mice: MDA-MB 231 and 4T1 cells implanted in the flank of mice. When tumors reached the planned volume, they are irradiated with 2x5 Gy and then surgically removed at different time points after RT. In the mean time between the end of RT and the surgical procedure, mice were imaged in a 9,4T Agilent® MRI. Diffusion Weighted (DW) -MRI was performed every 2 days between RT and surgery. For each tumors we acquired 8 slices of 1 mm thickness and 0.5 mm gap with an “in plane voxel resolution” of 0.5 mm. For DW-MRI, we performed FSEMS (Fast Spin Echo MultiSlice) sequences, with 9 different B-values (from 40 to 1000) and B0, in the 3 main directions. We also performed IVIM (IntraVoxel Incoherent Motion) analysis, in the aim to obtain information on intravascular diffusion, related to perfusion (F: perfusion factor) and subsequently tumor vessels perfusion. Results. As preliminary results, with the MBA-MB 231 we observed a significant increase of F at day 6 after irradiation than a decrease and stabilization until surgery. No other modifications of the MRI signal, ADC, D or D* were observed. We observed similar results with 4T1 cells, F increased at day 3 than returned to initial signal. The difference in the timing of the peak of F can be related to the difference in tumor growth between MBA-MB 231 and 4T1 (four weeks vs one week). Conclusion. For the first time, we demonstrate the feasibility of repetitive fMRI imaging in mice models after NeoRT. With these models, we show a significant peak of the perfusion factor (F) at day 6 or day 3. This change occurs between the two previous time points of surgery demonstrating a difference in the metastatic spreading. Indeed, after a NeoRT of 2X5Gy we observed more metastases in the lung when MDA-MB 231 tumor bearing mice are operated 4 days after RT compared to 11 days. These preliminary results are very promising for identifying noninvasive markers for determining the best timing for surgery. [less ▲]

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See detailPURIFICATION ET IDENTIFICATION DE PEPTIDES DOUES D’ACTIVITES BIOLOGIQUES A PARTIR DES HYDROLYSATS PROTEIQUES DE POIS CHICHE
MOKNI GHRIBI, Abir; SILA, Assaâd; PRZYBYLSKIC, Rémy et al

Conference (2016, March 22)

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See detailÉTUDE DES PROPRIETES RHEOLOGIQUES DES PATES A PAIN SANS GLUTEN
DOUIRI, Sabrine; Blecker, Christophe ULg; ATTIA, Hamadi et al

Conference (2016, March 22)

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See detailUne généralisation du triangle de Pascal
Stipulanti, Manon ULg

Conference (2016, March 22)

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word ... [more ▼]

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word. Similarly to the Sierpinski gasket that can be built as the limit set, for the Hausdorff distance, of a convergent sequence of normalized compact blocks extracted from Pascal triangle modulo 2, we describe and study the first properties of the subset of [0, 1]×[0, 1] associated with this extended Pascal triangle modulo a prime p. [less ▲]

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See detailGeophysical Investigation of the Pb-Zn deposit of Lontzen, Belgium
Evrard, Maxime ULg

Conference (2016, March 22)

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See detailOXIDATION OF ß-D-GLUCAN EXTRACTED FROM BAKER’S YEAST SACCHAROMYCES CEREVISIAE: PHYSICOCHEMICAL AND STRUCTURAL PROPERTIES
BORCHANI, Chema; FONTEYN, Fabienne; JAMIN, Guilhem et al

Conference (2016, March 21)

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See detailIMPACT OF EXTRACTION CONDITIONS ON CHEMICAL STRUCTURE, THERMAL PROPERTIES AND ANTIOXIDANT ACTIVITIES OF ULVAN FROM THE GREEN SEAWEED ULVA LACTUCA
Yaich, Hela; Garna, Haikel; Abbès, Fatma et al

Poster (2016, March 21)

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