References of "Scientific congresses and symposiums"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailNouvelle classification des acro-gigantismes
Rostomyan, Liliya ULg; Beckers, Albert ULg

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailA novel mutation of the luteinizing hormone/choionic gonadotrophin receptor gene leading to Leydig cell hypoplasia type I
Potorac, Iulia ULg; Rivero-Müller, A; Pintiaux, Axelle ULg et al

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailQuand science politique et droit dialoguent : quelle typologie des instruments mémoriels en fonction du degré de contrainte ?
Grandjean, Geoffrey ULg

Conference (2015, February 07)

Envisager les études sur la mémoire comme sous-champ de la science politique francophone ouvre des pistes enrichissantes pour les politologues, notamment lorsqu’ils sont amenés à analyser les instruments ... [more ▼]

Envisager les études sur la mémoire comme sous-champ de la science politique francophone ouvre des pistes enrichissantes pour les politologues, notamment lorsqu’ils sont amenés à analyser les instruments mémoriels régissant un ou plusieurs système(s) politique(s). Dans cette perspective, la communication vise à présenter, d’un point de vue épistémologique, les apports découlant de l’interaction entre les sciences politique et juridique dans le processus de consolidation des études sur la mémoire comme sous-champ disciplinaire de la science politique. Plus précisément, la communication vise à offrir une typologie des instruments mémoriels en fonction du degré de contrainte et d’imposition d’une mémoire officielle. Par exemple, une résolution adoptée par une assemblée législative est faiblement contraignante alors qu’une loi réprimant le négationnisme impose à la fois une mémoire officielle tout en sanctionnant pénalement les citoyens qui ne la respectent pas. La typologie passe en revue les multiples instruments mémoriels pouvant être adoptés par les autorités publiques : résolution, loi déclarative, loi pénale, plan de commémorations ou encore mise en valeur d’un lieu de mémoire. L’accent est mis sur les instruments mémoriels de deux pays francophones : la Belgique et la France. Au final, cette communication permet d’insister sur l’apport de la science politique en analysant l’exercice de prérogatives de puissance publique et sur l’apport de la science juridique en classifiant les types d’instruments mémoriels en fonction du degré de contrainte ; tout en faisant dialoguer des cas d’étude différents. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
See detailMédias et dette wallonne: polémique autour d'un indicateur de finances publiques
Piron, Damien ULg

Conference (2015, February 06)

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailComprendre les programmes électoraux : comparaison des méthodes d’encodage manuel et automatique
Piet, Grégory ULg; Dandoy, Régis; Joly, Jeroen

Conference (2015, February 06)

Detailed reference viewed: 22 (3 ULg)
See detailThe phosphorylation of RelA on Ser547 does not modulate NF-kB activation after TNFa treatment like after a genotoxic stress
Trussart, Charlotte ULg; Orban, Tanguy ULg; Di Valentin, Emmanuel ULg et al

Poster (2015, February 06)

NF-kB controls the expression of hundred of genes involved in inflammatory and innate responses, proliferation, survival, cancer initiation and progression. Numerous post-translational modifications of ... [more ▼]

NF-kB controls the expression of hundred of genes involved in inflammatory and innate responses, proliferation, survival, cancer initiation and progression. Numerous post-translational modifications of p65 modulating NF-kB transcriptional activity are known. We identified Ser547 as a new site of p65 phosphorylation targeted by ATM kinase, which coordinates the “DNA Damage Response” pathway in the event of DNA double-strand breaks. We demonstrated that the phosphorylation of Ser547 regulates the transcription of a sub-set of NF-κB dependent genes after genotoxic stress by modifying HDAC1 recruitment(1). Presently, we are investigating the role of this specific phosphorylation in an inflammatory context. We observe that the mutations of p65 (S547A or S547D) also affect the transcriptional potential of the NF-κB in a promoter specific manner after an exposition to TNFα and H2O2. The study of the molecular mechanism of this regulation after TNFα and H2O2 exposition are both in progress. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailDaily intake and bacteriological quality of meat consumed in the households of Kigali city (Rwanda)
Niyonzima, Eugène; Ongol, Martin Patrick; Kimonyo, Anasthase et al

Poster (2015, February 05)

Meat is worldwidely known to be a nutrient rich food. It provides valuable amounts of proteins,vitamins such as retinol and vitamin B12 and minerals namely iron, selenium and zinc with an increased ... [more ▼]

Meat is worldwidely known to be a nutrient rich food. It provides valuable amounts of proteins,vitamins such as retinol and vitamin B12 and minerals namely iron, selenium and zinc with an increased bioavailability than found in other dietary sources [1]. Along the production chain, meat can get contaminated by a wide range of spoilage and/or pathogenic microorganisms from the farm, slaughtering environment and distribution. The actual number of foodborne infections attributable to meat is difficult to assess accurately, principally because only a small proportion of illness cases is officially reported. However, by using outbreak data published internationally, Greig and Ravel [2] reported that 12.7 % of reported foodborne outbreaks were attributable to beef while 10.5 and 4.6 % were associated with chicken and pork, respectively. According to the same authors, Salmonella spp. and pathogenic E.coli, respectively, were identified as the causal agents in 32.9 and 34.6 % of foodborne outbreaks of bacterial origin attributable to beef. The objective of this study was to determine the meat consumption pattern in different socio-conomical categories of the population of Kigali city and to assess the bacteriological quality of the consumed meat. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailA mixed integer nonlinear programming bi-objective model for intermodal network design
Mostert, Martine ULg; Caris, An; Limbourg, Sabine ULg

Conference (2015, February 05)

Detailed reference viewed: 12 (1 ULg)
See detailRésistance aux antibiotiques : le retour à l’ère prébiotique ?
Galleni, Moreno ULg; Kerff, Frédéric ULg; Rigali, Sébastien ULg

Conference (2015, February 05)

Aujourd’hui, la résistance des bactéries aux antibiotiques relève d'une préoccupation croissante dans le domaine de la santé publique et s'impose plus que jamais comme une priorité. Ce problème a un coût ... [more ▼]

Aujourd’hui, la résistance des bactéries aux antibiotiques relève d'une préoccupation croissante dans le domaine de la santé publique et s'impose plus que jamais comme une priorité. Ce problème a un coût, sociétal et économique en Europe: 25.000 décès annuels par septicémie et 1,5 milliard d’euros d’augmentation du coût des traitements. Bien que le besoin de nouveaux agents antibactériens en milieu clinique est urgent, seules deux nouvelles classes d’antibiotiques ont pu être proposées durant ces 30 dernières années. En effet, la découverte et le développement de nouveaux antibiotiques posent des défis scientifiques, cliniques et financiers importants. [less ▲]

Detailed reference viewed: 40 (4 ULg)
See detailOutsider Science Fiction or the mainstreamisation of a genre
Guesse, Carole ULg

Conference (2015, February 04)

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailSite-specific height-diameter allometry of Central African moist forests
Loubota Panzou, Grâce Jopaul ULg; Doucet, Jean-Louis ULg; Fayolle, Adeline ULg

Poster (2015, February 04)

In this study we aimed to identify the variation in height-diameter allometry between forest types and among species in Central African moist forests. We also examined the consequences on biomass ... [more ▼]

In this study we aimed to identify the variation in height-diameter allometry between forest types and among species in Central African moist forests. We also examined the consequences on biomass estimation. Two forest sites in southern Cameroon with contrasting levels of deciduousness. Height and diameter were measured for a total of 521 trees belonging to 12 timber species over a large range of diameter, 10-240 cm for the Ma’an site and 11-182 cm for the Mindourou site. Non-destructive height measurements were calibrated with destructive measurements for a total of 60 trees, 30 in each site. Commercial forest inventory data (n=7253 0.5ha plots) were gathered for the Ma’an (n=34 samples and 2101 plots) and Mindourou (n=117 samples and 5152 plots) sites. A total of ten allometric models (including asymptotic and non-asymptotic models) were fitted to the height-diameter data at species (n=12) and site (n=2) level. Biomass estimates were computed based on forest inventory data and general allometric models using both site-specific and published height-diameter equations. Given the strong correlation between the non-destructive and destructive height measurements we had confidence in using the non-destructive height measurements to establish site- and species-specific height-diameter allometric equations. The height measurements performed over a wide range of diameters, 10-240 cm, tended to support an asymptotic shape (and most often the Michaelis Menten model) for the height-diameter allometry either at species and site level. We identified a significant difference in height-diameter allometry between the two study sites. For a given diameter, trees tended to be taller in the more semi-deciduous Mindourou site than in the more evergreen Ma’an site, with a maximum height of 39.5 and 46.5 m, respectively. The two sites significantly differed in stand structure and biomass. This difference is due to the variation in height-diameter allometry. Height-diameter allometry strongly varies between sites and site-specific height-diameter allometric equations should be developed to further improve the estimation of biomass and carbon stock contained in tropical forests. [less ▲]

Detailed reference viewed: 71 (32 ULg)
See detailReprogramming of replication origin firing and checkpoint adaptation in adult T-cell leukemia
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Boxus, Mathieu et al

Conference (2015, February 03)

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the ... [more ▼]

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). A key parameter of HTLV-1 pathogenesis is faster replication of provirus-carrying lymphocytes allowing clonal expansion of infected cell populations. The virally-encoded Tax oncoprotein plays an essential role in this process by interacting with DNA replication origins and accelerating S phase progression. By reprogramming the timing of origin firing, Tax also creates a replicative stress leading to DNA double strand breaks. This mechanism further triggers the DNA damage response (DDR) that induces cell cycle arrest and initiates either apoptosis or senescence. However, HTLV-1 infected cells have developed strategies to interfere with the DDR and are adapted to checkpoint control. These cells are thus able to proliferate despite occurrence of DNA damage. Based on these observations, we now propose a novel therapeutic approach based on the principle of synthetic lethality. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
See detailSuppression of Limit Cycle Oscillations using the Nonlinear Tuned Vibration Absorber
Habib, Giuseppe ULg; Kerschen, Gaëtan ULg

in Proceeding IMAC XXXIII A Conference and Exposition on Structural Dynamics, Orlando 2-5 February 2015 (2015, February 03)

The objective of the present study is to mitigate, or even completely eliminate, the limit cycle oscillations in mechanical systems using a passive nonlinear absorber, termed the nonlinear tuned vibration ... [more ▼]

The objective of the present study is to mitigate, or even completely eliminate, the limit cycle oscillations in mechanical systems using a passive nonlinear absorber, termed the nonlinear tuned vibration absorber (NLTVA). An unconventional aspect of the NLTVA is that the mathematical form of its restoring force is not imposed a priori, as it is the case for most existing nonlinear absorbers. The NLTVA parameters are determined analytically using stability and bifurcation analyses, and the resulting design is validated numerically using the MATCONT software. The proposed developments are illustrated using a Van der Pol-Du ng primary system. [less ▲]

Detailed reference viewed: 93 (22 ULg)
See detailMBD du laboratoire à la clinique
CAVALIER, Etienne ULg

Conference (2015, February 02)

Detailed reference viewed: 5 (0 ULg)
See detailMolecular diversity of microorganisms in Antarctic lacustrine microbial mats
Wilmotte, Annick ULg; Stelmach Pessi, Igor ULg; Sweetlove, Maxime et al

Conference (2015, February)

The BeSPO project CCAMBIO aims to study the biogeographical distribution of microorganisms in lacustrine microbial mats using a combination of techniques including microscopical observations (light and ... [more ▼]

The BeSPO project CCAMBIO aims to study the biogeographical distribution of microorganisms in lacustrine microbial mats using a combination of techniques including microscopical observations (light and electronic), strain isolation, and molecular diversity assessment using Next Generation Sequencing. The samples were collected in different Antarctic and sub-Antarctic biogeographical regions. A multivariate analysis of diatoms showed that these regions hosted different diatom flora. Endemic diatom taxa were also observed, and a multigene molecular phylogeny of Pinnularia borealis showed a high genetic diversity. A new Scenedesmacean species was described from Antarctica, Chodatodesmus australis. A comparison of the bacterial diversity retrieved by cultivation or NGS showed a complementarity of both approaches and differences when different variable regions of the 16S rRNA gene were used. Novel and unclassified sequences, also observed by other authors, were obtained. Pilot studies were conducted for the microeukaryotes and cyanobacteria to select NGS protocols and bioinformatic pipelines. The purpose is to deposit the diversity data in the “Microbial Antarctic Resource System (MARS)” presently developed into the webportal ‘biodiversity.aq’. [less ▲]

Detailed reference viewed: 51 (0 ULg)
Full Text
See detailLes PPP comme nouveau mode de régulation du marché de l'accompagnement des demandeurs d'emploi. A chaque modèle de partenariat son type de stratégie
Remy, Céline ULg

in Cahiers Loyola (2015, February), 1

Cette communication vise à montrer en quoi les partenariats publics-privés (PPP) constituent désormais un nouveau mode de régulation du marché de l’accompagnement des demandeurs d’emploi. Les services ... [more ▼]

Cette communication vise à montrer en quoi les partenariats publics-privés (PPP) constituent désormais un nouveau mode de régulation du marché de l’accompagnement des demandeurs d’emploi. Les services publics de l’emploi (SPE) doivent établir des PPP avec des prestataires de service pour la mise en place de formation à destination des demandeurs d’emploi. La réalisation de trois études de cas au sein des SPE, dont deux en Belgique et une en Suisse, nous permet de mettre en évidence une forte influence du modèle de gestion du PPP sur la collaboration entre les parties-prenantes mais aussi sur les stratégies développées par les prestataires pour surmonter les problèmes liés à la collaboration avec l’Office de l’Emploi et à la mise en place de la prestation de service. [less ▲]

Detailed reference viewed: 26 (4 ULg)
Full Text
See detailRugose corals from the Carboniferous of the eastern Tafilalt (Morocco): a progress report
Aretz, Markus; Denayer, Julien ULg

Conference (2015, February)

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailSingle-Molecule Force Spectroscopy on Synthetic Helical Nanoarchitectures
Devaux, Floriane ULg; Duwez, Anne-Sophie ULg; Huc, Ivan et al

Poster (2015, February)

Foldamers are artificial folded molecular architectures inspired by the structures and functions of natural biopolymers. Folding is the process selected by nature to control the conformation of its ... [more ▼]

Foldamers are artificial folded molecular architectures inspired by the structures and functions of natural biopolymers. Folding is the process selected by nature to control the conformation of its molecular machinery to carry out chemical functions and mechanical tasks, such as en-zyme catalysis, duplication in nucleic acids, force generation,... During the last decade of research on foldamers [1], synthetic oligomers able to adopt well-defined and predictable folded conformations, such as helices, have been proposed. Recent progress has shown that stepwise chemical synthesis and molecular design based on aromatic oligoamide backbones enable to produce large helically folded molecular architectures. The shape and stiffness of the backbone, local conformational preferences, specific interactions between distant monomers in sequences, as well as the action of external parameters such as the solvent or the presence of ions, can be combine to induce folding tendency. A remarkable aspect of these architectures is that they can give rise to folded patterns that have no in natural counterparts biopolymer structures. For instance, helices whose diameter varies along the se-quence, helices possessing a handedness inversion centre, herringbone helices have been reported. The objective of the project is to synthesize various helical nanorchitectures based on an oli-goamide aromatic backbone and to obtain a detailed picture of their dynamical conformation in solution, as well as, their mechanochemical properties, by AFM-based single molecule force spectroscopy. It is worth mentioning that an important sub-objective of this project is to probe intramolecular interactions in small synthetic molecules with the AFM. Indeed, whereas single-molecule force spectroscopy on macromolecules (proteins and synthetic polymers) is widely exploited[2], implementing single-molecule force spectroscopy on small molecules, such as the foldamers proposed here, remains a major challenge[3]. [1] For a review, see G. Guichard and I. Huc, Chem. Commun. 2011, 47, 5933–5941. [2]E. M. Puchner, H. E.Gaub, Curr. Opin. Struct. Biol. 2009, 19, 605–614. [3]P. Lussis, A.-S. Duwez, Nature Nanotech. 2011, 6, 553-557 [less ▲]

Detailed reference viewed: 42 (4 ULg)
Full Text
Peer Reviewed
See detailAzione, testualizzazione, notazione
Dondero, Maria Giulia ULg

in Espressione e contenuto. Rivista on-line dell'AISS Associazione Italiana di Studi Semiotici (2015, February), 18/19

Detailed reference viewed: 20 (1 ULg)
Full Text
See detailBridging the gap between Nonlinear Normal Modes and Modal Derivatives
Sombroek, Cees; Renson, Ludovic ULg; Tiso, Paolo et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

Nonlinear Normal Modes (NNMs) have a clear conceptual relation to the classical linear normal modes (LNMs), yet they offer a solid theoretical framework for interpreting a wide class of non-linear ... [more ▼]

Nonlinear Normal Modes (NNMs) have a clear conceptual relation to the classical linear normal modes (LNMs), yet they offer a solid theoretical framework for interpreting a wide class of non-linear dynamical phenomena with no linear counterpart. The main difficulty associated with NNMs is that their calculation for large-scale models is expensive, particularly for distributed nonlinearities. Repeated direct time integrations need to be carried out together with extensive sensitivity analysis to reproduce the frequency-energy dependence of the modes of interest. In the present paper, NNMs are computed from a reduced model obtained using a quadratic transformation comprising LNMs and Modal Derivatives (MDs). Previous studies have shown that MDs can capture the essential dynamics of geometrically nonlinear structures and can greatly reduce the computational cost of time integration. A direct comparison with the NNMs computed from another standard reduction technique highlights the capability of the proposed reduction method to capture the essential nonlinear phenomena. The methodology is demonstrated using simple examples with 2 and 4 degrees of freedom. [less ▲]

Detailed reference viewed: 50 (1 ULg)
Full Text
Peer Reviewed
See detailCore-shell AgSiO2-Protoporphyrin IX nanoparticle: Effect of the Ag core on reactive oxygen species generation
Lismont, Marjorie ULg; Pàez Martinez, Carlos ULg; Dreesen, Laurent ULg

in SPIE proceeding - Colloidal Nanoparticles for Biomedical Applications X (2015, February)

Photodynamic therapy (PDT) for cancer is based on the use of a light sensitive molecule to produce, under specific irradiation, toxic reactive oxygen species (ROS). A way to improve the therapy efficiency ... [more ▼]

Photodynamic therapy (PDT) for cancer is based on the use of a light sensitive molecule to produce, under specific irradiation, toxic reactive oxygen species (ROS). A way to improve the therapy efficiency is to increase the amount of produced ROS near cancer cells. This aim can be achieved by using a metal enhanced process arising when an optically active molecule is located near a metallic nanoparticle (NP). Here, the coupling effect between silver (Ag) NPs and protoporphyrin IX (PpIX) molecules, a clinically approved photosensitizer, is studied compared first, to PpIX fluorescence yield and second, to ROS production efficiency. By applying a modified Stöber process, PpIX was encapsulated into a silica (SiO2) shell, surrounding a 60 nm sized Ag core. We showed that, compared to SiO2-PpIX NPs, Ag coated SiO2-PpIX NPs dramatically decreased PpIX fluorescence together with singlet oxygen production efficiency. However, after incubation time in the dark, the amount of superoxide anions generated by the Ag doped sample was higher than the control sample one. [less ▲]

Detailed reference viewed: 47 (8 ULg)
Full Text
Peer Reviewed
See detailMultiplicity editing in long-range heteronuclear correlation NMR experiments: Application to natural products
Sauri, Josep; Sistare, E.; Frederich, Michel ULg et al

Poster (2015, February)

Detailed reference viewed: 13 (5 ULg)
Full Text
See detailLes procédures secondaires sous l'empire du nouveau Règlement insolvabilité
Wautelet, Patrick ULg

Conference (2015, February)

Cette présentation tire le bilan d'une dizaine d'années d'application des dispositions du Règlement 1346/2000 relatives aux procédures secondaires et trace les contours du nouveau régime des procédures ... [more ▼]

Cette présentation tire le bilan d'une dizaine d'années d'application des dispositions du Règlement 1346/2000 relatives aux procédures secondaires et trace les contours du nouveau régime des procédures secondaires sous l'empire du Règlement révisé [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
See detailThe Late Viséan Rugose coral association of NW Turkey
Denayer, Julien ULg

Conference (2015, February)

Detailed reference viewed: 13 (0 ULg)
Full Text
See detailExperimental nonlinear identification of an aircraft with bolted connections
De Filippis, Giovanni; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

Aircraft structures are known to be prone to nonlinear phenomena, especially as they constantly become lighter and hence more flexible. One specific challenge that is regularly encountered is the modeling ... [more ▼]

Aircraft structures are known to be prone to nonlinear phenomena, especially as they constantly become lighter and hence more flexible. One specific challenge that is regularly encountered is the modeling of the mounting interfaces between aircraft subcomponents. Indeed, for large amplitudes of vibration, such interfaces may loosen and, in turn, trigger complex mechanisms such as friction and clearances. In this context, the present work intends to investigate the nonlinear dynamics of the Morane–Saulnier Paris aircraft, accessible at ONERA. This aircraft possesses multiple bolted connections between two external fuel tanks and wing tips. The objective of the paper is specifically to carry out an adequate identification of the numerous nonlinearities affecting the dynamics of this full-scale structure. Nonlinearity detection and the subsequent subspace-based parameter estimation have been performed on experimental data, collected during an on-ground test campaign. Nonlinearity detection is first achieved by the comparison of frequency response functions estimated at low excitation level, with those obtained at high amplitude level, yielding insight towards accurately characterizing the behavior of the bolted connections. Then, a nonlinear subspace identification method is applied to measured data to estimate the linear and nonlinear parameters of the structure and novel strategies and tools that overcome specific arisen problems are developed. [less ▲]

Detailed reference viewed: 48 (2 ULg)
Peer Reviewed
See detailPrévalence du virus du SDRP dans les élevages porcins
Czaplicki, Guy; Thilmant, Pierre; Van Der Stede, Yves et al

Poster (2015, February)

Porcine reproductive and respiratory syndrome (PRRS) causes major economic losses in pig farms. In different parts of the world, there is growing consensus that PRRS virus (PRRSv) eradication should be ... [more ▼]

Porcine reproductive and respiratory syndrome (PRRS) causes major economic losses in pig farms. In different parts of the world, there is growing consensus that PRRS virus (PRRSv) eradication should be performed on a regional basis, particularly in low density areas of pig production. The objective of the present study was to evaluate the apparent prevalence of PRRSv in Wallonia, a low density area of pig production (0.05 pig farms/km²). A phone survey was addressed to 173 of the 276 Walloon breeding pig owners. One hundred and thirty‐two farmers answered the questionnaire and serological tests were performed in 113 herds. If no vaccination was carried out on sows or on piglets, an Elisa test was performed on 10 breeding and/or 5 feeder pig serum samples collected between November 2011 and December 2012. An individual result was considered negative if the s/p ratio was <0.4; a herd was considered positive if an s/p ratio ≥0.4 was obtained by at least one of its pigs. Globally, at herd level and at animal level, the apparent prevalences were respectively 48% (IC95%: 39 – 57%) and 32 % (IC 95%: 29 – 35%). The present study has shown that half the Walloon breeding pig farms are serologically positive for PRRSv. Such prevalence in an area of low pig production supports the project for a regional PRRS control program. [less ▲]

Detailed reference viewed: 15 (1 ULg)
See detailCyanobacteria - the constructors of travertines?
Kleinteich, Julia; Stelmach Pessi, Igor ULg; Velazquez, David et al

Conference (2015, February)

Cyanobacteria are participating in carbonate build-up and travertine formation in the Belgian river Hoyoux and its tributaries. In this study, we sampled calcareous material from travertines and oncoliths ... [more ▼]

Cyanobacteria are participating in carbonate build-up and travertine formation in the Belgian river Hoyoux and its tributaries. In this study, we sampled calcareous material from travertines and oncoliths from four sampling sites on the Hoyoux river and Triffoy brook. In addition, the water chemistry was determined. The structure of the material was analyzed by Scanning Electron Microscopy and Raman microscopy (?°. The dominant cyanobacterial species was isolated and identified on the basis of microscopic observation and amplification of the 16S-ITS fragment as Phormidium sp., likely functioning as the ‘architect’ of the travertine system. In order to describe the full diversity of the travertine system and to discriminate between the active fraction and inactive or dead organic matter, DNA as well as RNA was extracted from the travertine material, amplified using cyanobacteria specific primers and sequenced by 454 pyrosequencing. To detect seasonal changes in the biological activity, summer and winter time points were compared. This study reveals the ecology of an overlooked environment in Belgian river systems and tries to explain the build-up of travertines. [less ▲]

Detailed reference viewed: 48 (12 ULg)
Full Text
See detailEarly detection of university students in potential difficulty
Hoffait, Anne-Sophie ULg; Schyns, Michael ULg

Conference (2015, February)

Rate of success in the first year at University in Belgium is very low regarding other foreign universities. The University of Liege, as other Universities, has already taken different initiatives. But by ... [more ▼]

Rate of success in the first year at University in Belgium is very low regarding other foreign universities. The University of Liege, as other Universities, has already taken different initiatives. But by early identifying students who have a high probability to face difficulties if nothing is done, the Universities might develop adapted methods to attack the problem with more emphasis where it is more needed and when it is still possible. Thus we want to develop a decision tool able to identify these students to help them. For that, we consider three standard datamining methods: logistic regression, artificial neural networks and decision trees and focus on early detection, i.e. before starting at the University. Then, we suggest to adapt these three methods as well as the classification framework in order to increase the probability of correct identification of the students. In our approach, we do not restrict the classification to two extreme classes, e.g. failure or success, but we create subcategories for different levels of confidence: high risk of failure, risk of failure, expected success or high probability of success. The algorithms are modified accordingly and to give more weight to the class that really matters. Note that this approach remains valid for any other classification problems for which the focus is on some extreme classes; e.g. fraud detection, credit default... Finally, simulations are conducted to measure the performances of the three methods, with and without the suggested adaptation. We check if the factors of success/failure we can identify are similar to those reported in the literature. We also make a ``what-if sensitivity analysis''. The goal is to measure in more depth the impact of some factors and the impact of some solutions, e.g., a complementary training or a reorientation. [less ▲]

Detailed reference viewed: 23 (12 ULg)
Full Text
Peer Reviewed
See detailAnalytical procedure to derive P-I diagram of a beam under explosion
Hamra, Lotfi ULg; Demonceau, Jean-François ULg; Denoël, Vincent ULg

in Proceeding of the IABSE Workshop - Safety, Robustness and Condition Assessments of Structures (2015, February)

The aim of this paper is to study a beam extracted from a frame and subjected to blast loading. The demand of ductility depends on six dimensionless parameters: two related to the blast loading, two ... [more ▼]

The aim of this paper is to study a beam extracted from a frame and subjected to blast loading. The demand of ductility depends on six dimensionless parameters: two related to the blast loading, two referring to the bending behaviour of the beam and two corresponding to the dynamic behaviour of the rest of the structure. We develop a full analytical procedure that provides the ductility demand as a function of these six dimensionless parameters. [less ▲]

Detailed reference viewed: 41 (15 ULg)
Full Text
Peer Reviewed
See detailFrequency support among asynchronous AC systems through VSCs emulating power plants
Papangelis, Lampros ULg; Guillaud, Xavier; Van Cutsem, Thierry ULg

in Proc. 11th IET Conference on AC and DC Power Transmission (2015, February)

This paper proposes a new control scheme for the Voltage Source Converters (VSCs) of a High Voltage Direct Current (HVDC) grid connecting asynchronous AC systems, so that the latter can mutually support ... [more ▼]

This paper proposes a new control scheme for the Voltage Source Converters (VSCs) of a High Voltage Direct Current (HVDC) grid connecting asynchronous AC systems, so that the latter can mutually support their frequencies after a disturbance. The scheme involves no communication between VSCs. It is activated upon detection of a significant frequency deviation, with the possibility to limit the support requested from other AC systems. It relies on an integral control enforcing the frequency droop characteristics (of classical speed governors), in addition to the voltage-droop control of VSCs. The controller is tuned to emulate the response of a power plant, while avoiding excessive transients in the HVDC system, and limiting the impact on the other AC systems. [less ▲]

Detailed reference viewed: 73 (21 ULg)
Full Text
Peer Reviewed
See detailRobust impact design of steel and composite building structures: the alternate load path approach
Hoffmann, Nadine; Kuhlmann, Ulrike; Demonceau, Jean-François ULg et al

in Proceeding of the IABSE Workshop - Safety, Robustness and Condition Assessments of Structures (2015, February)

Vulnerability of structures to progressive collapse and mitigation of the effects of local damages are topics widely discussed. The studies worldwide carried out allowed identifying different design ... [more ▼]

Vulnerability of structures to progressive collapse and mitigation of the effects of local damages are topics widely discussed. The studies worldwide carried out allowed identifying different design strategies. However, specific knowledge is still limited and this gap is apparent in codes of practice. A European project focusing on robustness of steel and steel and concrete composite structures regarding the effects of impact recently started combining the 2 methods of residual strength and alternate load path. In the framework of the project activities, the Authors aimed their studies on the redundancy of the structure through slab-beam-systems and ductile joint as well as on the local behaviour of the impacted members. For this analytical, numerical and experimental investigations have been planned and executed. The paper describes the experimental activities related to the investigations on the structural redundancy and presents the preliminary test outcomes. [less ▲]

Detailed reference viewed: 39 (6 ULg)
Peer Reviewed
See detailLordose et/ou xyphose chez le porc : mise à l’épreuve de l’hypothèse héréditaire
Laitat, Martine ULg; Veillat, Emilie; Van Cauwenberge, Henry et al

Poster (2015, February)

Lordosis and/or kyphosis, also called ”dipped shoulder” or ”humpy‐back” is sporadically observed in growing pigs. This condition is characterized by a thoracic and/or lumbar spinal deformity ... [more ▼]

Lordosis and/or kyphosis, also called ”dipped shoulder” or ”humpy‐back” is sporadically observed in growing pigs. This condition is characterized by a thoracic and/or lumbar spinal deformity. Pathomorphologically, it may be comparable with Scheuermann’s kyphosis in man and so constitutes a spontaneous model for this humane kyphosis of the thoracic or thoracolumbar spine. In pigs, this condition may decrease the value of carcasses, making deboning efforts challenging. Three major and non‐exclusive hypotheses formulated to explain these back deformations are nutrition, intrauterine viral infection and inherited predisposition. The objective of the present study was to test the latter and, if possible, to identify a locus (some loci) associated with the affection. Forty‐eight pigs were included in this case‐control study. Based on a clinical examination and/or on a measure of the degree of spinal deformity, 25 pigs classified as affected were compared to 23 pigs considered as normal. A whole genome Single Nucleotide Polymorphism (SNP) analysis was performed using a 50,000 SNP array. DNA from forty‐seven samples (tail tissue or blood) was extracted while one sample was eliminated because of its poor quality. After applying quality controls, 40 pigs and 57,838 SNPs (on a total of 62,163) remained for further analysis. One SNP (ASGA0090747) located on Sus scrofa chromosome SSC8 crossed the genome‐wide significant threshold and is thus suspected of being associated with the lordosis and/or kyphosis phenotype. These results seem to confirm the hereditary hypothesis. Further investigations are however needed to confirm the suspected association. [less ▲]

Detailed reference viewed: 25 (6 ULg)
Full Text
See detailScanning the genome for QTL affecting the recombination process in the male and female cattle germline
Kadri, Naveen Kumar ULg; Harland, Chad ULg; Coppieters, Wouter ULg et al

Poster (2015, February)

We herein study genetic recombination in three dairy cattle population from France, New-Zealand and The Netherlands. We apply a new phasing algorithm extracting familial information suited for large half ... [more ▼]

We herein study genetic recombination in three dairy cattle population from France, New-Zealand and The Netherlands. We apply a new phasing algorithm extracting familial information suited for large half-sib families to reconstruct haplotypes and detect cross-overs. The software is robust to genotyping errors and map errors (genome builts still contain errors for non-model organisms). We identify more than 2,000,000 cross-over events in sperm cells transmitted by 2942 sires to 94,049 offspring, and more than 500,000 cross-over events in oocytes transmitted by 10,943 cows to 23,850 offspring. The estimated number of cross-overs per gamete and its accuracy were influenced by the family structure (number of offsprings, parents and grand-parents genotyped). The average number of cross-overs in males (24.0) was larger than in females (21.8), even after correction for family structure. In males, recombination rates were higher closer to telomeres whereas in females, recombination rates dropped at both centromeres and telomeres (probably as a result of lower informativity). The heritability of the global recombination rate was close to 0.20 in males and to 0.10 in females and the genetic correlation was ~0.70, indicating that common genes are influencing both traits. Genome-wide association studies clearly confirmed QTL located close to REC8 and RNF212 in males. The QTL associated to REC8 was also detected in females and there was a positive correlation between QTL effects in males and females. The QTL associated to REC8 accounted for ~10% of the genetic variance in both males and females. [less ▲]

Detailed reference viewed: 18 (9 ULg)
Full Text
See detailExperimental modal analysis of nonlinear structures using broadband data
Noël, Jean-Philippe ULg; Renson, Ludovic ULg; Grappasonni, Chiara ULg et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

The objective of the present paper is to develop a rigorous identification methodology of nonlinear normal modes (NNMs) of engineering structures. This is achieved by processing experimental measurements ... [more ▼]

The objective of the present paper is to develop a rigorous identification methodology of nonlinear normal modes (NNMs) of engineering structures. This is achieved by processing experimental measurements collected under broadband forcing. The use of such a type of forcing signal allows to excite multiple NNMs simultaneously and, in turn, to save testing time. A two-step methodology integrating nonlinear system identification and numerical continuation of periodic solutions is proposed for the extraction of the individual NNMs from broadband input and output data. It is demonstrated using a numerical cantilever beam possessing a cubic nonlinearity at its free end. The proposed methodology can be viewed as a nonlinear generalization of the phase separation techniques routinely utilized for experimental modal analysis of linear structures. The paper ends with a comparison between this new nonlinear phase separation technique and a previously-developed nonlinear phase resonance method. [less ▲]

Detailed reference viewed: 42 (10 ULg)
See detailRole of the progesterone receptor in the development of sexual behavior in female mice
Desroziers, Elodie ULg; Brock, Olivier; Baum, M.J. et al

Poster (2015, February)

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailRobust impact design of steel and composite building structures
Hoffman, Nadine; Kuhlmann, Ulrike; Demonceau, Jean-François ULg et al

in Proceeding of the IABSE Workshop - Safety, Robustness and Condition Assessments of Structures (2015, February)

Detailed reference viewed: 45 (8 ULg)
Full Text
See detailExperimental demonstration of a 3D-printed nonlinear tuned vibration absorber
Grappasonni, Chiara ULg; Habib, Giuseppe ULg; Detroux, Thibaut ULg et al

in Proceedings of the International Modal Analysis Conference (IMAC) XXXIII (2015, February)

Engineering structures are designed to be lighter and more flexible, hence reducing the extent of application of linear dynamic models. Concurrently, vibration mitigation is required for enhancing the ... [more ▼]

Engineering structures are designed to be lighter and more flexible, hence reducing the extent of application of linear dynamic models. Concurrently, vibration mitigation is required for enhancing the performance, comfort or safety in real-life applications. Passive linear vibration absorbers are purpose-built, often designed using Den Hartog's equal-peak strategy. However, nonlinear systems are known to exhibit frequency-energy-dependent oscillations which linear absorbers cannot effectively damp out. In this context, the paper introduces a new nonlinear tuned vibration absorber (NLTVA) whose nonlinear functional form is tailored according to the frequency-energy dependence of the nonlinear primary structure. The NLTVA design aims at ensuring equal peaks in the nonlinear receptance function for an as large as possible range of forcing amplitudes, hence generalizing Den Hartog's method to nonlinear systems. Our focus in this study is on experimental demonstration of the NLTVA performance using a primary structure consisting of a cantilever beam with a geometrically nonlinear component at its free end. The absorber is implemented using a doubly-clamped beam fabricated thanks to 3D printing. The NLTVA performance is also compared with that of the classical linear tuned vibration absorber. [less ▲]

Detailed reference viewed: 86 (7 ULg)
See detailConformational properties of helical foldamers under force
Willet, Nicolas ULg; Hinterdorfer, Peter; Lecommandoux, Sébastien et al

Conference (2015, February)

The aim of this study is to investigate the mechanochemical behavior of foldamers able to change their conformation is a stimuli-responsive way. Peptidic secondary structures were studied in detail by ... [more ▼]

The aim of this study is to investigate the mechanochemical behavior of foldamers able to change their conformation is a stimuli-responsive way. Peptidic secondary structures were studied in detail by atomic force microscopy (AFM) at the single-molecule level. Synthetic copolymers containing a polypeptide block were prepared by N-carboxyanhydride amino acid ring-opening polymerization. The polymer chains were grafted onto gold surfaces and their mechanochemical behavior was then studied by AFM single-molecule force spectroscopy (SMFS). The investigated polypeptide blocks were based on polyglutamate, which undergoes transitions from alpha-helix to random coil. This can be induced by external stimuli (pH, ionic strength, temperature) or simply by applying a force. The mechanically driven unfolding of the helical foldamer was characterized in detail. Stretching the folded peptide resulted in original features in the force-distance traces. Plateaus that are specific for the helical conformation were detected, quantified and discussed. Pulling-relaxing SMFS experiments were performed and led to a better understanding of the mechanically induced unfolding of an alpha-helix as a reversible phenomenon. [less ▲]

Detailed reference viewed: 28 (0 ULg)
Peer Reviewed
See detailDépasser la situation : de la situation-limite à la personnalité borderline. Généalogie, critique et clinique d’un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

Conference (2015, January 31)

Nous souhaitons interroger ici le concept sartrien de situation à partir d’une double approche historique et psychopathologique qui semble en diagnostiquer la disparition tout aussi bien conceptuelle ... [more ▼]

Nous souhaitons interroger ici le concept sartrien de situation à partir d’une double approche historique et psychopathologique qui semble en diagnostiquer la disparition tout aussi bien conceptuelle qu’existentielle : la notion de situation, organisatrice de l’ontologie phénoménologique de Sartre et pivot de son engagement, semble s’être aujourd’hui désintégrée en tant que concept (voir ses usages pseudo-conceptuels dans les domaines de la pédagogie et du management), alors que ce qu’on appelle la « condition postmoderne », telle qu’elle s’exprime dans de nouvelles symptomatologies psychopathologiques, rend apparemment caduque, face à la fragmentation des repères de l’existence, l’exigence de penser en/la situation. Nous procèderons en trois temps. Nous ferons d’abord la généalogie du concept, dont l’application à la psyché humaine et à la représentation théâtrale de celle-ci remonte, selon Leo Spitzer, à la fin du 17ème siècle. Dans cette première section, nous insisterons en particulier sur le rapport que l’élaboration du concept de situation entretient, au début du 20ème siècle, avec l’émergence de la psychopathologie notamment chez Jaspers (« situation-limite ») et chez Minkowski (nous rappellerons à cet égard le rôle de Gabriel Marcel dans le champ philosophique français de l’entre-deux-guerres). Nous serons également attentifs à la critique méthodologique que le concept de situation permet d’adresser à la métapsychologie freudienne. Sur cette base, nous reprendrons ensuite les principales étapes chez Sartre de la prise en considération de l’homme en situation et des possibilités de dépassement de cette situation. Nous envisagerons successivement l’Esquisse d’une théorie des émotions, « Questions de méthode » et L’Idiot de la famille. Il conviendra certes de rappeler comment l’existentialisme, comme le situationnisme à sa façon, a cherché, dans le sillage du marxisme, à réaliser la philosophie et du coup à transformer le concept en vécu. Mais nous montrerons aussi, à rebours, comment l’œuvre sartrienne, confrontée aux exigences conjointes du marxisme et de la psychanalyse (cf. l’analyse des pressions familiales dans le Flaubert), a dû dépasser le cadre de la magie émotionnelle au sein duquel la notion de situation s’était d’abord élaborée. Au-delà de la « situation sartrienne » – et peut-être en la prolongeant –, la critique de Deleuze des dispositifs nous servira enfin, dans un troisième temps, de point de bascule vers la condition postmoderne et la fragmentation de la situation en tant que repère d’existence. Le sujet borderline – véritable éclat de la postmodernité – nous permettra ainsi de conclure en reprenant le propos psychopathologique maturé par l’évolution conceptuelle de la situation. Nous caractériserons l’existence borderline par une fragmentation du soi corrélée à une explosion, voire à un morcellement, des espaces de vie qui répondent à la nécessité ontologique d’une « ubiquité instantanée » dénuée de présence corporelle (comme le permettent les espaces virtuels « connectés »). [less ▲]

Detailed reference viewed: 50 (9 ULg)
Full Text
See detailMyoferlin Regulates Endosomal Trafficking and Tunes Cancer Cell Metabolism
Blomme, Arnaud; Costanza, Brunella; Thiry, Marc ULg et al

Poster (2015, January 31)

Detailed reference viewed: 6 (0 ULg)
See detailHDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism
Hendrick, Elodie ULg; Peixoto, Paul ULg; Polese, Catherine ULg et al

Poster (2015, January 31)

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum ... [more ▼]

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum inhibitors of these enzymes such as SAHA can inhibit tumor growth both in vitro and in vivo and are currently used as anti-cancer agents in clinic. For many years, we are investigating the specific role of individual HDAC members in cancer biology and we have recently demonstrated that specific depletion of HDAC5 using siRNA technology reduced cancer cells proliferation and survival1 The goal of this study is to further understand the molecular mechanisms of action of HDAC5 in cancer cells. Screening transcriptomic study demonstrated that HDAC5 depletion induces a down-regulation of subunits of the complex I of the mitochondrial respiratory chain (NDUFB5-NDUFA3) as well as anti-oxydant proteins (Ferritin, Metalothionein,¿) through modulation of mRNA stability. Therefore, HDAC5 depletion causes a significant increase of ROS production inducing both apoptosis and mechanisms of mitochondria quality control (mitophagy and mitobiogenesis). This HDAC5 depletion-induced mitochondrial dysfunction provokes metabolic adaptation associated with increased importance of glucose and glutamine. Indeed, interference with both glucose and glutamine supply in HDAC5-depleted cancer cells significantly increases apoptotic cell death suggesting that glucose or glutamine deprivation might be combined to HDAC5 inhibition as a therapeutic strategy to kill cancer cells. Our study demonstrated for the first time that specific HDAC5 inhibition induces metabolic reprogramming and provides insight into a valuable experimental strategy for manipulation of specific HDAC5 inhibition and glucose metabolism in therapy against cancer. 1.Peixoto, P. et al. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell death and differentiation, 2012; 1-14. Presenting author e-mail: elodie.hendrick@student.ulg.ac.be [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
See detailActivités physiques, représentations et femmes
Cloes, Marc ULg

Conference (2015, January 31)

Il est admis internationalement que les filles et les femmes représentent un public à risque en matière de sédentarité. Cette conférence interactive vise à répondre à trois questions: (1) L’activité ... [more ▼]

Il est admis internationalement que les filles et les femmes représentent un public à risque en matière de sédentarité. Cette conférence interactive vise à répondre à trois questions: (1) L’activité physique, qu’est-ce que c’est? (2) A quoi ça sert? (3) Qu’est-ce qu’il faut faire, finalement? Au-delà de la volonté de faire vivre aux participants une expérience originale, les objectifs finaux de l'intervention consistent à permettre une prise de conscience et à proposer des pistes d’action. [less ▲]

Detailed reference viewed: 65 (3 ULg)
Full Text
Peer Reviewed
See detailElicitation of the defence mechanisms at plant case of Cucumis melo
Ydjedd, Siham; Kati, D.E.; Fauconnier, Marie-Laure ULg

Poster (2015, January 30)

The judicious use of elicitors could reduce the amount of pesticide necessary to protect crops and preservation of the environment. This strategy frequently called "stimulation of natural defenses ... [more ▼]

The judicious use of elicitors could reduce the amount of pesticide necessary to protect crops and preservation of the environment. This strategy frequently called "stimulation of natural defenses" arouses more and more interest in the phytosanitary field. [less ▲]

Detailed reference viewed: 35 (5 ULg)
Peer Reviewed
See detailLessons from the field: Negotiating Transnational Gender, Class and Race Positions as a Researcher Working on Andean Domestic Workers in Brussels
Vivas Romero, Maria ULg

Conference (2015, January 30)

This paper shows the links between migrant transnationalism and the methodological debates concerning the researcher’s positionality and self-reflexivity, which have not been systematically considered in ... [more ▼]

This paper shows the links between migrant transnationalism and the methodological debates concerning the researcher’s positionality and self-reflexivity, which have not been systematically considered in transnational studies. Drawing from my experiences as a transnational female migrant conducting fieldwork among Andean domestic workers in the city of Brussels; I intent to contribute to the conceptualization of positionality by reflecting on the effect of the researcher’s transnational gender, class and race positions in qualitative migration research. Firstly, I address the conflicts that arose from my positioning as an “insider” that initially granted me a social proximity with my participants but later raised awareness on the existent social boundaries between us and temporarily blocked my access to the field. Secondly, I will highlight the methodological strategies through, which I worked around the existent boundaries of power relations and eventually gained access to the field, meaning: A- Constantly, engaging in self-reflexivity and questioning my “insider/outsider positioning, B- Consciously and unconsciously negotiating my class, gender and race positioning’s in order to re-draw the boundaries in the relationship between the participants and the researcher, C- Relying on my experiences as a transnational migrant in order to grasp the meaning of their practices, which guided me to avoid my spontaneous interpretations and reconsider those that my participants gave me . Finally, I will argue that both mobilizing one’s personal background and negotiating our intersecting transnational positionalities during fieldwork constitute valuable methodological resources that might lead us to do research that is produced through more symmetrical relations. [less ▲]

Detailed reference viewed: 43 (12 ULg)
Full Text
See detailInfluence of cover crop management on sugar beet production
Hiel, Marie-Pierre ULg; Bodson, Bernard ULg

Poster (2015, January 30)

Detailed reference viewed: 30 (9 ULg)
Full Text
See detailWildflower strips for crop protection: What do we know ? What should we know ?
Hatt, Séverin ULg; Uyttenbroeck, Roel ULg; Bodson, Bernard ULg et al

Poster (2015, January 30)

Wildflower strips (WFS) are known to support the conservation of a large diversity of insects and thus natural enemies (i.e. predators and parasitoids) that can control pests. However, the conclusions of ... [more ▼]

Wildflower strips (WFS) are known to support the conservation of a large diversity of insects and thus natural enemies (i.e. predators and parasitoids) that can control pests. However, the conclusions of studies looking at the efficiency of WFS to control pests are not unanimous. Indeed, the enhancement of pest control seems to depend on (1) the ability of flowers to attract the natural enemies at the right moment and (2) the capacity of natural enemies to migrate into the adjacent crops to attack pests. Therefore, constituting appropriate flower mixes may be an essential lever to enhance the efficiency of pest control. In this context, using functional diversity is promising. To our knowledge, few studies have tested the impact of the functional diversity of a flower mix on insect abundance and diversity and the control of pests. Through this contribution, the insect diversity and abundance found to be associated with the different kinds of WFS and management applied will be discussed, as well as the further research needed. [less ▲]

Detailed reference viewed: 36 (12 ULg)
Full Text
See detailBiochemical methane potential of residues of three banana varieties from Cameroon : fresh and dry peduncles
Awedem wobiwo, Florent; Happi Emaga, Thomas; Fokou, Elie et al

Poster (2015, January 30)

In Cameroon , the ratio of energy cost to standard of living for both electric and fuel energy is higher than in USA and EU. The local energy needs could be met by valorizing local wastes in an ... [more ▼]

In Cameroon , the ratio of energy cost to standard of living for both electric and fuel energy is higher than in USA and EU. The local energy needs could be met by valorizing local wastes in an environmentally and economically sustainable way. Banana and plantain plants produce significant quantities of post-harvest biomass wastes such as bulbs, pseudo stems, leaf sheaths, petioles–midribs, leaf blades, peduncles, rachis and blossoms which can be converted to methane-rich biogas by anaerobic digestion (AD). AD is a natural process of degradation of organic materials. [less ▲]

Detailed reference viewed: 38 (4 ULg)
Full Text
See detailUtility of removing cholesterol from an industrial by-product- Buttermilk powder
Malik, Priyanka ULg; Danthine, Sabine ULg; Paul, Aman ULg et al

Poster (2015, January 30)

Almost 16% of milk produced in European Union is being converted to butter. Buttermilk, is a low cost by-product from butter manufacture and available in large quantities but has been considered ... [more ▼]

Almost 16% of milk produced in European Union is being converted to butter. Buttermilk, is a low cost by-product from butter manufacture and available in large quantities but has been considered invaluable for many years. When cream is churned to butter the stable oil in water emulsion is destabilized and milk fat globule membrane (MFGM) is disrupted which is released in buttermilk. Thus, over the last two decades it has gained considerable attention due to its specific composition (proteins and polar lipids) attributed towards the MFGM. In account to this composition of buttermilk powder, it finds application in food industry as a natural stabilizing and emulsifying agent. It also finds application as a source of total solids and is commercially being added upto 10% in many food products. However, it has limitation in such applications due to the presence of cholesterol (approx. 80mg/100g). Cholesterol is also an integral part of MFGM and is released into buttermilk with MFGM. The most suitable techniques to remove cholesterol from buttermilk powder are using β-cyclodextrin and cholesterol oxidase enzyme. To valorize this abundantly produced industrial by-product of butter industry and increase its application in health food industry, as well as extend its application in pharmaceutical industry and preparation of liposomes, it is important to remove cholesterol from buttermilk. [less ▲]

Detailed reference viewed: 11 (2 ULg)
Full Text
Peer Reviewed
See detailInteractions of natural rhamnolpids produced by Pseudomonas aeruginosa with plant model membranes
Polo Lozano, Damien ULg; Nasir, Mehmet Nail ULg; Deleu, Magali ULg et al

Poster (2015, January 30)

It is well known that chemical pesticides have harmful effects on human health and environment. In this context, the interest for alternative products such as biopesticides is increasing. Among them ... [more ▼]

It is well known that chemical pesticides have harmful effects on human health and environment. In this context, the interest for alternative products such as biopesticides is increasing. Among them, elicitors act on the plants by inducing systemic resistance against diseases caused by fungal, viral, bacterial agents and insects. Rhamnolipids are surface active molecules produced mainly by various strains of the bacterium Pseudomonas aeruginosa. These secondary metabolites are composed of one to three fatty acids with various chain lengths linked through a glycosidic bond to one or two rhamnose moieties. The fatty acids are linked together through an ester bond. These molecules have shown several biological activities including plant defense stimulation. It has been suggested that this elicitor activity could be related to an interaction of rhamnolipids with the lipid bilayer of the plant plasma membrane (PPM) and lead to its destabilization, which can activate the plant defense signaling pathways. In this context, interactions of two rhamnolipids (Rha-C10-C10 and Rha-Rha-C10-C10) with biomimetic membranes of PPM such as Langmuir monolayers and multilayers were investigated using biophysical and in silico approaches. [less ▲]

Detailed reference viewed: 39 (5 ULg)
Full Text
See detailNitrous oxide flux measurement with a closed chamber system : data treatment
Regaert, Donat ULg; Moureaux, Christine ULg; Heinesch, Bernard ULg et al

Poster (2015, January 30)

Nitrous oxide flux estimation from concentration measurements with a closed chamber system. Statistical data treatment to sort between relevant/irrelevant fluxes.

Detailed reference viewed: 13 (4 ULg)
Full Text
See detailAzacytidine prevents experimental sclerodermic chronic graft-versus-host disease
Fransolet, Gilles ULg; Ehx, Grégory ULg; SOMJA, Joan ULg et al

Poster (2015, January 30)

Introduction: Graft-versus-host disease (GVHD) remains one major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Following unmanipulated peripheral-blood stem cell ... [more ▼]

Introduction: Graft-versus-host disease (GVHD) remains one major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Following unmanipulated peripheral-blood stem cell transplantation, 60% of the patients experience chronic GVHD while approximately 15% of them develop a sclerodermic form of chronic GVHD characterized by multiple organ fibrosis and loss of skin elasticity. Regulatory T cells (Tregs) play a pivotal role in the pathology of chronic GVHD by inhibiting alloreactive conventional T cells. Several studies have shown the hypomethylating agent Azacytidine (Aza) can demethylate the master transcription factor of Treg (Forkhead box protein 3 factor, FoxP3), thus promoting Treg differentiation of conventional T cells. This work investigates the impact of Aza in a classical murine model of sclerodermic chronic GVHD (B10.D2  BALB/cJ). Methods: Lethally irradiated BALB/cJ recipient mice were injected with 107 bone marrow cells + 7.107splenocytes from B10.D2 donor mice. Recipients were treated with subcutaneous injections of Aza at the dose of 0,5 or 2 mg/kg every two days from day 10 to 30 following transplantation. Mice GVHD was evaluated with five criteria (weight loss, activity, fibrosis, hair loss and mice posture; 0-1-2 points/criteria). Mice were sacrificed at a score of 8/10 (or > 20% weight loss). Results: Mice treated with Aza 0.5 mg/kg (n = 14) or 2 mg/kg (n = 17) had significant lower clinical scores compared to control ones (n = 15) after treatment. FACS analysis showed a higher proportion of Treg among CD4+ T cells in the blood of Aza 2 mg/kg mice than in control mice (P = 0.047), as well as a higher percentage of Tregs expressing the KI67 proliferative marker on the same day (P = 0.0005). Finally, analyses of the cellular blood components with Cell-dyn demonstrated that Aza 2 mg/kg treated mice were significantly lymphopenic as compared to control mice (P = 0.05). Conclusion : Aza prevented sclerodermic GVHD in this classical murine model of chronic GVHD. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
See detailStudy of durability and the physico-mechanical properties of thermally modified wood
Ninane, Maxime; Jourez, Benoît ULg; Hebert, Jacques ULg

Poster (2015, January 30)

Heat-treated wood is a credible alternative for certain kinds of tropical timber. It is also an alternative for certain polluting wood preservatives. This study aims to determine the changes in physico ... [more ▼]

Heat-treated wood is a credible alternative for certain kinds of tropical timber. It is also an alternative for certain polluting wood preservatives. This study aims to determine the changes in physico-mechanical properties and durability of wood that is subjected to heat treatment. For this, we studied five species (oak, ash, natural beech and a variant known as steamed beech, poplar, Douglas-fir). For each species, we had fifteen reference samples and fifteen corresponding treated samples. The results show a decrease in the hygroscopicity and an increase in dimensional stability of heat-treated wood in relation to the degradation of hemicelluloses. The mechanical properties are influence variously, because heat-treated wood is stiffer but also more brittle. The modulus of elasticity increases slightly after treatment. Side hardness and compressive fracture of heat-treated wood may increase up to 30%. On the other hand, the modulus of rupture, the ability to slit and impact may decrease by 50%, 60% and 70%. The durability of heat-treated wood against wood-destroying fungi increases. However, within each species, the durability increase varies greatly. Additional tests conducted to understand this variability, suggests that the heat distribution is not homogeneous within the processing unit. Moreover, our work suggests that durability is related to the fixed carbon content and that this path would be interesting to explore in the future. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Full Text
See detailEvaluation et gamification - Transformer un quiz de chimie en un mini-jeu
le Maire, Nathalie ULg; Fauconnier, Marie-Laure ULg; Colaux, Catherine ULg et al

Conference (2015, January 30)

Le recours à des questionnaires à choix multiples pour l’évaluation des étudiants est une pratique courante à l’université. Cette communication décrit et analyse une expérimentation contrôlée visant à ... [more ▼]

Le recours à des questionnaires à choix multiples pour l’évaluation des étudiants est une pratique courante à l’université. Cette communication décrit et analyse une expérimentation contrôlée visant à explorer les effets de la présentation d’un QCM formatif sous la forme d’un jeu. L’étude s’inscrit ainsi dans les recherches actuelles sur les avantages et les limites pédagogiques de la « gamification », à savoir la transposition des principes issus de l’univers du jeu au domaine de l’éducation (Johnson, Adams Becker, Estrada, & Freeman, 2014). La présente recherche est effectuée dans le cadre d’un doctorat dédié spécifiquement à la gamification d’évaluations formatives. L’étude repose sur la mise à disposition de plusieurs versions d’un quiz portant sur un chapitre d’un cours de chimie générale en première année d’université. Le dispositif expérimental prévoit un enrichissement graduel de la gamification selon quatre prototypes conçus après identification et extraction de schèmes visant à stimuler et maintenir la motivation et la performance dans des jeux actuels et populaires tels que Candy Crush, Angry Birds ou Hay Day. Située à l’entrée du doctorat, cette étude vise, outre la collecte de données quant à l’utilisabilité du mini-jeu proposé, à mettre en lumière ses effets sur l’état de flow dans le contexte des edugames et contribuera à la validation de la traduction française de l’échelle d’EGameFlow (Fu, Su, & Yu, 2009). [less ▲]

Detailed reference viewed: 56 (11 ULg)
Full Text
See detailLangmuir film balance- A technique to study the interaction of β-cyclodextrin with cholesterol in milk fat globule membrane monolayers
Malik, Priyanka ULg; Danthine, Sabine ULg; Paul, Aman ULg et al

Poster (2015, January 30)

Milk is a natural complex system present as oil in water emulsion. The natural organisation of milk fat globules is stabilized by the presence of a natural membrane, called the milk fat globule membrane ... [more ▼]

Milk is a natural complex system present as oil in water emulsion. The natural organisation of milk fat globules is stabilized by the presence of a natural membrane, called the milk fat globule membrane (MFGM). It has tripartite structure consisting of a monolayer facing the inner triacylglycerol core and an external bilayer. This MFGM accounts for 2-6% of fat globule. The MFGM is composed of both polar lipids and proteins. Cholesterol is also present in MFGM and accounts for about 2% of MFGM. Langmuir film balance is a technique to study monolayers and is a useful tool to examine the effect of cholesterol removal on surface properties of MFGM. β-cyclodextrin has no surface activity of its own and is thus a useful tool to study the effect of cholesterol desorption on surface properties in membrane. The removal of monolayer cholesterol to the sub-phase is proportional to the area decrease of the monolayer at a constant surface pressure. Amount of cholesterol removed can also be calculated as a function of mean molecular area at a given pressure, time and temperature. Using the monolayer technique, it is possible to study the interactions between β-cyclodextrin and MFGM film as well as effect of cholesterol removal in altering the surface properties MFGM. [less ▲]

Detailed reference viewed: 26 (3 ULg)
See detailAzacytidine augments regulatory T cells and prevents experimental xenogeneic graft-versus-host disease.
Ehx, Grégory ULg

Conference (2015, January 30)

The demethylating agent 5-azacytidine (AZA) has proven its efficiency in myeloid malignancies treatment. Recently, several studies have shown that AZA also presents an immunomodulatory activity, mainly ... [more ▼]

The demethylating agent 5-azacytidine (AZA) has proven its efficiency in myeloid malignancies treatment. Recently, several studies have shown that AZA also presents an immunomodulatory activity, mainly through the induction of regulatory T cells (Treg) differentiation from conventional T cells. Treg promotion is a promising treatment option for graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. In this way, AZA has been shown to reduce GVHD in mouse-to-mouse transplantation models. However, the impact of AZA on human GVHD remains elusive as well as its effects on human Treg and on the other T cell subsets in vivo. Here we report AZA impact on GVHD in a xeno-transplantation model of the disease and describe the overall effects of the drug on human T cells in vivo. When administered to NSG mice receiving 2.107 human PBMC intravenously, AZA successfully ameliorated both survival (p < 0.001) and GVHD score. Flow cytometry analyses showed that this improvement may be mediated through an anti-proliferative effect of AZA on human T cells while these cells presented an increased activation state. We also observed a significant decrease of Th1 and 2 differentiation, assessed by RT-qPCR and cytokines secretion assays, and a reduced production of granzyme B and perforin 1 by cytotoxic T cells. As expected, AZA dramatically augmented Treg frequency while we could also observe a promotion of their IL-2 mediated proliferation over conventional T cells. Interestingly, Th17 frequency was not affected by AZA, therefore increasing the balance Treg/Th17. Finally our data suggest that AZA-induced Treg may have an improved suppressive activity and present long-term stability in vivo. Altogether our findings suggest that AZA may be a promising treatment option for GVHD in the clinical setting. [less ▲]

Detailed reference viewed: 11 (2 ULg)
Full Text
See detailInvestigating the Effects of Plant Root Exudates on PAHs Bioavailability to Soil Microorganisms in Contaminated Brownfields : Research Methodology.
Davin, Marie ULg; Lognay, Georges ULg; Fauconnier, Marie-Laure ULg et al

Poster (2015, January 30)

As a result of heavy industrial past activities, an estimated 6,000 brownfields require remediation in Wallonia. This number rises to over 3.5 million in Europe. Polycyclic Aromatic Hydrocarbons (PAHs ... [more ▼]

As a result of heavy industrial past activities, an estimated 6,000 brownfields require remediation in Wallonia. This number rises to over 3.5 million in Europe. Polycyclic Aromatic Hydrocarbons (PAHs) represent 17% of treated pollutants in Wallonia (Aldric et al., 2011). Current remediation techniques are rather expensive and technically demanding (Megharaj et al., 2011). Based on the observation that PAHs soil content decreases in the presence of plants (Cheema et al., 2010), the PhD aims at developing alternative PAHs remediation techniques in brownfields. It is articulated around three research axes. The first axis focusses on plant exudates and how they may improve PAHs bioavailability to soil microorganisms and enhance their degradation. This will be investigated by (i) characterizing several contaminated soils (physico-chemical parameters) and PAH content and factors of bioavailability, (ii) selecting a plant model and collecting root exudates, and (iii) evaluating the effects of exudates on PAHs bioavailability. The objective of the second axis is to evaluate the effects of plant exudates on PAHs degrading microorganisms by (i) comparing PAHs biodegradation in the presence/absence of exudates and (ii) assessing the potential toxic effects of exudate compounds on the microbial communities. The aim of the third axis is to study plant-pollutants interactions by (i) establishing the plant tolerance to several contamination levels and (ii) following PAHs bioavailability when facing real exudation rates, on the field. [less ▲]

Detailed reference viewed: 37 (3 ULg)
Full Text
See detailLinking bees and flowers: mutualistic interaction networks to study ecosystem functioning
Uyttenbroeck, Roel ULg; Monty, Arnaud ULg

Poster (2015, January 30)

In recent years, much attention is going to pollinators, as they are important for the increasing food production while being threatened by agricultural intensification and other environmental drivers ... [more ▼]

In recent years, much attention is going to pollinators, as they are important for the increasing food production while being threatened by agricultural intensification and other environmental drivers. While honeybees (Apis mellifera L.) are generalist according to their flower preferences, wild pollinators’ flower preferences can go from generalist to very specialist. The same goes for plant species, which can be generalist or specialist in the pollinator species they need to get pollinated. The combination of a set of generalist and specialist plant species with a pollinator community consisting of generalists and specialists in a certain habitat, results in an interaction network between pollinators and the visited plant flowers. Studying this mutualistic interaction network is a time-consuming method, but can provide valuable data to calculate indicators of ecosystem functioning. One of the important conclusions that came already out of studies applying this method is that pollination systems are often more generalized than thought based on pollination syndromes. This poster will explore the method of studying mutualistic interaction networks with a focus on the sampling protocol, the indicators that can be derived from the data and their meaning. [less ▲]

Detailed reference viewed: 68 (7 ULg)
Full Text
Peer Reviewed
See detailGrille de correction: déclinaisons de la perception et des réalisations
Bonnet, Pierre ULg; Delvenne, Philippe ULg; Defaweux, Valérie ULg et al

Conference (2015, January 29)

Un outil disponible on-line pour la correction des questions ouvertes à réponse courte ou longue (QROC et QROL) est utilisé depuis plusieurs années au sein de l’ULg. Les copies réponse des étudiants sont ... [more ▼]

Un outil disponible on-line pour la correction des questions ouvertes à réponse courte ou longue (QROC et QROL) est utilisé depuis plusieurs années au sein de l’ULg. Les copies réponse des étudiants sont scannées et corrigées sur un écran d’ordinateur. L’enseignant fournit l’énoncé de la question et une grille de correction suivant un canevas prédéfini. La correction évalue une série de critères regroupés par 4 à l’écran. Chaque critère défini est évalué au moyen d’une échelle horizontale allant de 0 à 100% suivant que le critère n’est pas rencontré (0%) ou qu’il est totalement développé (100%) par l’étudiant. L’enseignant peut graduer cette échelle en y indiquant des repères (indices). La pondération des différents critères est définie à priori ou à posteriori. Sur cette base de travail commune, nous analysons la façon dont cette grille est utilisée pour corriger des questions relatives à des matières médicales différentes enseignées par différents professeurs : histologie, anatomie, physiologie et anatomopathologie. L’analyse fait ressortir que malgré un canevas commun, les modalités de correction sont variables ce qui témoigne de la différence existant entre les matières, les compétences évaluées et, probablement, la sensibilité des enseignants. A l’inverse, ceci démontre la souplesse de l’outil adaptable à des types d’évaluations différents. [less ▲]

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailFéminiser la voix
Morsomme, Dominique ULg; Remacle, Angélique ULg

Conference (2015, January 29)

Parlée ou chantée, notre voix révèle qui nous sommes. Elle participe à notre identité et véhicule nos émotions (ref. Revis. J). Dans cet exposé, nous présenterons la voix du point de vue du genre. En ... [more ▼]

Parlée ou chantée, notre voix révèle qui nous sommes. Elle participe à notre identité et véhicule nos émotions (ref. Revis. J). Dans cet exposé, nous présenterons la voix du point de vue du genre. En effet, l’Unité Logopédie de la Voix (www.logopedie-voix.be) s’intéresse entre autres à la féminisation vocale chez les personnes transidentitaires, en processus de changement de genre. Ces personnes ne s’identifiant pas au sexe et au genre qui leur ont été attribués à la naissance, elles éprouvent un désir profond de vivre comme une personne du sexe opposé à leur sexe biologique. Lors du processus de transition où ont lieu les transformations nécessaires au changement de genre, la logopédie a pour but d’améliorer la cohérence entre l’apparence de la personne et sa voix. Ainsi, notre recherche se focalise sur ce qui distingue la voix féminine de la voix masculine. Nous visons à développer des stratégies de féminisation vocale, portant sur des paramètres tels que la fréquence fondamentale de la voix (grave ou aigüe), les contours intonatifs, le niveau d’amplitude de certains formants, le débit de parole, son rythme, ou encore le vocabulaire choisi. Féminiser une voix, c’est chercher à comprendre ce qui permet d’en identifier le genre, mais également participer à la construction de l’identité de la personne à part entière. [less ▲]

Detailed reference viewed: 34 (8 ULg)
Full Text
Peer Reviewed
See detailCompétences complexes en Anatomie : évaluation par QCM
Bonnet, Pierre ULg; Ernst, Denise ULg; Defaweux, Valérie ULg

Conference (2015, January 29)

L’apprentissage de l’Anatomie débute en faculté de Médecine par un cours d’introduction dispensé à toutes les premières années de baccalauréat de la faculté: Médecins, Kinésithérapeutes, Sciences de la ... [more ▼]

L’apprentissage de l’Anatomie débute en faculté de Médecine par un cours d’introduction dispensé à toutes les premières années de baccalauréat de la faculté: Médecins, Kinésithérapeutes, Sciences de la Motricité, Dentistes, Pharmaciens et Sciences Biomédicales. Outre les objectifs d’apprentissage spécifiques anatomiques, le dispositif d’enseignement vise à atteindre des objectifs transversaux : sens de l’observation, capacité de description, vision dans l’espace. Ces capacités sont entraînées au travers d’un apprentissage mixte (présentiel et on-line), tant pour les aspects théoriques que pratiques, faisant appel à la réalisation de schémas et à l’analyse d’images et de vidéos. Les cohortes d’étudiants sont importantes (1500 étudiants) ce qui rend obligatoire le recours à des moyens d’évaluation automatisés : Questions à Choix Multiples et feuille de réponse à lecture optique. Dans ce contexte, nous avons développé des énoncés de question à choix multiples basés soit sur des notions théoriques, soit sur l’analyse de schémas simples soit sur des exercices à résoudre. Afin de parfaire l’alignement pédagogique, des vidéos explicatives portant sur la résolution d’exercices type sont disponibles sur le cours on-line. Un sondage réalisé auprès des étudiants et une analyse de l’utilisation des outils du cours confirment la cohérence du dispositif. Les résultats globaux peuvent être ventilés en 3 cotes suivant le type de questions utilisées : théorie, analyse, exercice. Cette information renseigne l’étudiant sur le niveau et le type de compétences acquises et devrait permettre de construire des évaluations mieux adaptées à la finalité différente des 6 sections concernées par une pondération variable des types de question. [less ▲]

Detailed reference viewed: 31 (3 ULg)
Peer Reviewed
See detailPistes de réflexion et propositions d'outils pour optimaliser l'évaluation des tâches complexes en langues modernes et tendre vers plus d'équité
Simons, Germain ULg; Pagnoul, Pierre ULg

Conference (2015, January 28)

Dans cette communication, nous présentons une analyse critique du document "Familles de tâches en langues modernes" de la FWB et ouvrons différentes pistes pour optimiser cet outil. Par ailleurs, nous ... [more ▼]

Dans cette communication, nous présentons une analyse critique du document "Familles de tâches en langues modernes" de la FWB et ouvrons différentes pistes pour optimiser cet outil. Par ailleurs, nous proposons un dispositif d'observation/évaluation dans lequel les élèves sont amenés à s'approprier les critères de qualité d'une tâche complexe en interaction orale. [less ▲]

Detailed reference viewed: 45 (6 ULg)
Full Text
See detailÉvaluations à large échelle : prendre la mesure des effets de contexte
Lafontaine, Dominique ULg

Conference (2015, January 28)

The communication (Keynote conference) give a comprehensive overview of how contexts have been taken into account in large-scale international assessments of achievement. The following topics are ... [more ▼]

The communication (Keynote conference) give a comprehensive overview of how contexts have been taken into account in large-scale international assessments of achievement. The following topics are investigated: 1) the growing importance of contextual questionnaires in PISA 2) the response-style biases and how they can jeopardize validity and comparability of measures (especially of self-reported non-cognitive outcomes measured by Likert scales) 3) the frame-of-reference (group) effects (BFLPE) and their differential impact depending on the structure of education systems. [less ▲]

Detailed reference viewed: 32 (2 ULg)
Full Text
Peer Reviewed
See detailUsing shear strain localisation to model the fracturing around gallery in unsaturated Callovo-Oxfordian claystone
Pardoen, Benoît ULg; Levasseur, Séverine ULg; Collin, Frédéric ULg

in Chau, Kam Tim; Zhao, Jidong (Eds.) Bifurcation and Degradation of Geomaterials in the New Millennium (2015, January 28)

Galleries drilling leads to damage propagation, fracturing and properties modifications in the surrounding medium. The prediction of the damaged zone behaviour is an important matter and needs to be ... [more ▼]

Galleries drilling leads to damage propagation, fracturing and properties modifications in the surrounding medium. The prediction of the damaged zone behaviour is an important matter and needs to be properly assessed. To do so the fractures can be modelled using shear strain localisation. The coupled local second gradient model is used under unsaturated conditions to correctly model the strain localisation behaviour. The permeability evolution and the rock desaturation due to air ventilation in galleries are considered. Finally, a hydro-mechanical modelling of a gallery excavation in Callovo-Oxfordian claystone is performed leading to a fairly good representation of the damaged zone. [less ▲]

Detailed reference viewed: 76 (23 ULg)
Full Text
See detailL’évaluation entre pairs dans des travaux de groupes : Impacts sur la motivation et sur la perception des étudiants
Colaux, Catherine ULg

Conference (2015, January 28)

La faculté de Gembloux Agro Bio Tech qui forme principalement des bioingénieurs propose à ses étudiants de première année un nouveau cours intitulé « Question d’actualité en environnement ; projet ». Ce ... [more ▼]

La faculté de Gembloux Agro Bio Tech qui forme principalement des bioingénieurs propose à ses étudiants de première année un nouveau cours intitulé « Question d’actualité en environnement ; projet ». Ce cours qui se veut avant tout être un cours d’intéressement se construit autour du questionnement des étudiants sur une thématique fixée, par le prisme de leurs matières enseignées en première année. Habitués aux cours ex-cathedra organisés dans de grands amphithéâtres, les 300 étudiants de première année se retrouvent répartis en groupes de 6 étudiants et doivent réaliser les travaux associés à ce cours en utilisant deux outils de collaboration asynchrones à savoir Diigo et un wiki. La construction de ce cours leur laisse une grande liberté d’organisation. Seules 8h de présentiel sont placées à l’horaire. Les étudiants doivent donc s’organiser entre eux pour soumettre dans les délais imposés deux travaux qu’ils devront réaliser collaborativement et en ligne. L’évaluation de ce cours n’est pas associée à un examen traditionnel. La note finale est construite sur base des deux travaux rendus par les étudiants plus un travail individuel de réflexion sur l’expérience de travail de groupe. Pour chacun des travaux rendus, les étudiants bénéficient de la même note collective reflétant la qualité du travail soumis plus une note individuelle qui reflète quant à elle la participation de l’étudiant dans le travail de groupe. Si lors de la première année cette participation individuelle était sanctionnée par l’enseignant qui avait accompagné le groupe, nous avons cette année, donné la responsabilité à l’étudiant d’évaluer la participation de ses pairs. Cette communication analysera l’impact de ce style de notation sur la motivation et la perception du cours par les étudiants. [less ▲]

Detailed reference viewed: 10 (2 ULg)
Full Text
See detailMyoferlin regulates endosomal trafficking and tunes cancer cell metabolism
Blomme, Arnaud; Costanza, Brunella; Thiry, Marc ULg et al

Poster (2015, January 27)

Detailed reference viewed: 12 (0 ULg)
Full Text
See detailLocalization of rDNA transcription sites within reptilian nucleoli
Bartholomé, Odile ULg; Franck, Claire; Thiry, Marc ULg

Poster (2015, January 27)

Detailed reference viewed: 9 (2 ULg)
Full Text
See detail[18F]UCB-H as a new PET radiotracer for Synaptic vesicle protein 2A: A first clinical trial
Bahri, Mohamed Ali ULg; Stifkens, Mathieu; Bastin, Christine ULg et al

Poster (2015, January 27)

SV2A is widely distributed in the brain and has been demonstrated to be involved in vesicle trafficking. The critical role of SV2A in proper nervous system function is shown, e.g., by the fact that it is ... [more ▼]

SV2A is widely distributed in the brain and has been demonstrated to be involved in vesicle trafficking. The critical role of SV2A in proper nervous system function is shown, e.g., by the fact that it is a binding site and the primary mechanism of levetiracetam. Levetiracetam is an antiepileptic drug which has recently been suggested to reduce synaptic deficits in a mouse model for Alzheimer’s disease. We here aimed to investigate the cerebral distribution of [18F]UCB-H, which has a high affinity with the SV2A. Dynamic PET data of the head of 4 healthy volunteers were acquired over 100 minutes after injection of 170.4 ± 24.9 MBq of GMP produced [18F]UCB-H. The arterial input function (IF) was obtained by blood sampling. The IF was also derived from the dynamic data using the correlation coefficient method. Blood data revealed a consistent amount of [18F]UCB-H in whole blood and plasma indicating a very low degree of binding of the tracer to the red blood cells. The image-derived arterial IFs were showed to be very similar to the measured ones with a peak-ratio around 0.91 and an area-under-curve ratio about 0.98. The [18F]UCB-H PET data showed a high and rapid uptake in the grey matter structures, matching the known ubiquitous distribution of the SV2A in the brain. The kinetics of the tracer in the brain was characterized by an initial high uptake phase followed by rapid washout allowing the standard compartmental modeling (1-tissue, 2-tissue, and Logan Plot). The three models gave similar results with both the measured and image-derived IFs. The total distribution volume of the tracer in the brain was greater than 7 mL/cm3. Our results suggest that [18F]UCB-H is a good candidate as radiotracer for brain SV2A proteins and could be used for human studies. Image-derived IF showed to be useful for quantitative studies without the need to the arterial blood sampling. SV2A modifications may consequently be assessed in neurological pathologies such as Alzheimer’s disease. [less ▲]

Detailed reference viewed: 66 (18 ULg)
See detailDéveloppement de nouveaux marqueurs neuroradiologiques de la maladie de Parkinson par reconnaissance de motifs
Himri, Khadidja ULg; Depierreux, Frédérique ULg; GARRAUX, Gaëtan ULg

Poster (2015, January 27)

Background and objectives: Automatic classification of Parkinson’s disease (PD) versus healthy controls (HC) based on structural MRI has so far focused on unimodal approaches. However, this method is ... [more ▼]

Background and objectives: Automatic classification of Parkinson’s disease (PD) versus healthy controls (HC) based on structural MRI has so far focused on unimodal approaches. However, this method is subject to a poor temporal and spatial resolution leading to low classification accuracy. To overcome this limitation we propose to integrate different modalities by generating a single decision function based on a multi-kernel method, exploiting the complementary information it offers. We predict that the integration of multiple modalities produces greater classification enhancement. Materials and methods: 3Tesla MRI was acquired in 42 patients with PD and 42 age and gender matched healthy controls. We relied on Unified Parkinson’s Disease Rating Scale (UPDRS) for evaluating the clinical status. We used structural and quantitative maps of T1, T2*, proton density (PD), magnetization transfer (MT), Multi-parameter (MT magnetization transfer, proton density (A), Iron Deposit (R2 *), mixing water content, iron, and the fraction of macromolecules tissues (R1) at 1 × 1 × 1 mm3 resolution. We identified cortical and subcortical brain regions (cortex, putamen, globus pallidus, substantia nigra), and cortical grey matter. We applied existing classification algorithms in the field of neuroscience using a classification algorithm based on Support Vector Machines (SVMs) [1], executed using the Pattern Recognition for Neuroimaging Toolbox (PRoNTo) [2]. The processes of classification was the following, data were mean centered and leave one subject out cross-validation was performed, making the test set independent from the training set. Analyses were restricted to voxels where all subjects had non-zero values. Statistical significance of the classifications was tested using permutation testing (1000 permutations) with random assignment of group class to the input image. Subsequently, we combined different modalities (MT, A, R1, R2) and identified the combination giving the highest sensitivity and sensibility in PD classification. As classifier we used support vector machines that are inspired by statistical learning theory Vladimir Vapnik and Multiple Kernel Learning approach, introduced by Lanckriet [3],[4]. Our approach can be seen as an analogue of MKL with SVMs. Conclusion & Future work: Identification of brain areas with affected intensity in the Parkinson’s group compared to Healthy Controls in single modalities using pronto is helpful. However, the subsequent multi-kernel approach utilizes unimodal information in a combined fashion so that emergent information is obtained, transcending effectiveness unimodal approaches. In conclusion, our findings suggest that combining different imaging modalities and different regions of interest increase classification accuracy significantly. These results are promising for objective diagnosis in medical practice. [less ▲]

Detailed reference viewed: 47 (6 ULg)
Full Text
See detailExploration of volumetric cerebral changes, with de micro-MRi, due to psychomotor exercise in mice
Moës, Florian ULg; Plenevaux, Alain ULg; Becker, Guillaume ULg et al

Poster (2015, January 27)

It's well know that exercise is good for health .In addition exercise has postive effects on cognition ,neurodegenerative disease and on mood. Some studies show that exercise has effect on brain so the ... [more ▼]

It's well know that exercise is good for health .In addition exercise has postive effects on cognition ,neurodegenerative disease and on mood. Some studies show that exercise has effect on brain so the aim of this study is to see if there are volumetric changes due to exercise or not. [less ▲]

Detailed reference viewed: 27 (7 ULg)
Peer Reviewed
See detailHuman cortical excitability depends on time awake and circadian phase
Gaggioni, Giulia ULg; Ly, Julien; Chellappa, Sarah Laxhmi ULg et al

Poster (2015, January 27)

Detailed reference viewed: 20 (10 ULg)
Full Text
See detailAccumulation of methylglyoxal, a glycolysis by-product modulates YAP1 transcription co-factor localization and activity in human breast cancer cells through HSP90 modification
Nokin, Marie-Julie; Durieux, Florence; Peixoto, Paul et al

Poster (2015, January 27)

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailMyoferlin: an indispensable component in VEGR-A secretion by pancreatic cancer cell
Fahmy, Karim; Gonzalez, Arnaud; Arafad, Mohamed et al

Poster (2015, January 27)

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailAPPUI ANALYTIQUE A LA LUTTE CONTRE LES MEDICAMENTS DE QUALITE INFERIEURE
Mbinze Kindenge, Jérémie; Hubert, Philippe ULg; Marini Djang'Eing'A, Roland ULg

Conference (2015, January 27)

Detailed reference viewed: 20 (2 ULg)
See detailHDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism
Hendrick, Elodie ULg; Peixoto, Paul ULg; Polese, Catherine ULg et al

Poster (2015, January 27)

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum ... [more ▼]

Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum inhibitors of these enzymes such as SAHA can inhibit tumor growth both in vitro and in vivo and are currently used as anti-cancer agents in clinic. For many years, we are investigating the specific role of individual HDAC members in cancer biology and we have recently demonstrated that specific depletion of HDAC5 using siRNA technology reduced cancer cells proliferation and survival1 The goal of this study is to further understand the molecular mechanisms of action of HDAC5 in cancer cells. Screening transcriptomic study demonstrated that HDAC5 depletion induces a down-regulation of subunits of the complex I of the mitochondrial respiratory chain (NDUFB5-NDUFA3) as well as anti-oxydant proteins (Ferritin, Metalothionein,¿) through modulation of mRNA stability. Therefore, HDAC5 depletion causes a significant increase of ROS production inducing both apoptosis and mechanisms of mitochondria quality control (mitophagy and mitobiogenesis). This HDAC5 depletion-induced mitochondrial dysfunction provokes metabolic adaptation associated with increased importance of glucose and glutamine. Indeed, interference with both glucose and glutamine supply in HDAC5-depleted cancer cells significantly increases apoptotic cell death suggesting that glucose or glutamine deprivation might be combined to HDAC5 inhibition as a therapeutic strategy to kill cancer cells. Our study demonstrated for the first time that specific HDAC5 inhibition induces metabolic reprogramming and provides insight into a valuable experimental strategy for manipulation of specific HDAC5 inhibition and glucose metabolism in therapy against cancer. 1.Peixoto, P. et al. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell death and differentiation, 2012; 1-14. Presenting author e-mail: elodie.hendrick@student.ulg.ac.be [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
See detailBacterial DNA mimetics activate platelets and promote thrombosis via CLEC-2
Delierneux, Céline; Hego, Alexandre; Lecut, Christelle et al

Poster (2015, January 27)

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailLe testing adaptatif informatisé : une brève introduction
Magis, David ULg

Conference (2015, January 27)

L’objet de cet exposé est de présenter les grands principes et concepts du testing adaptatif informatisé (TAI). Les éléments abordés sont : le TAI face au test fixe (papier-crayon), les principes généraux ... [more ▼]

L’objet de cet exposé est de présenter les grands principes et concepts du testing adaptatif informatisé (TAI). Les éléments abordés sont : le TAI face au test fixe (papier-crayon), les principes généraux du TAI (banque d’items, estimation provisoire et finale de la compétence, sélection des items à administrer, règles d’arrêt), les principes spécifiques au TAI (contrôle de l’exposition des items, équilibrage du contenu des tests). L’exposé se veut didactique et général afin de dessiner les contours du TAI. Il se termine par un état de l’art sur les recherches actuelles sur le TAI. [less ▲]

Detailed reference viewed: 45 (3 ULg)
Full Text
See detailEffects of α-synuclein levels on cerebral synaptic function: Validation of a novel PET radioligand for the early diagnosis of Parkinson’s disease
Tarragon Cros, Ernesto ULg; Ferrara, André ULg; Tirelli, Ezio ULg et al

Poster (2015, January 27)

Background In Parkinson’s disease, converging evidence supports a pathogenic role for excessive α–synuclein accumulation in synaptic terminals that may propagate back to the soma of vulnerable nerve cells ... [more ▼]

Background In Parkinson’s disease, converging evidence supports a pathogenic role for excessive α–synuclein accumulation in synaptic terminals that may propagate back to the soma of vulnerable nerve cells such as neurons in the substantia nigra pars compacta. The resulting loss of dopaminergic terminals in the striatum can be demonstrated in vivo using 18F-Dopa-PET (positron emission tomography). However, there’s currently no validated biomarker of the progressive synaptic dysfunction in other vulnerable areas such as the cerebral cortex. Goal In this longitudinal study, we will test the hypothesis that the loss of synaptic terminals in a mouse model of excessive α–synuclein accumulation can be demonstrated in vivo before the occurrence of behavioural disturbances using 18F-UCB-H, a new PET biomarker developed at CRC. We will also test if this new imaging modality is sensitive enough to study the effect of a disease modifying therapy such as chronic physical exercise. Methods We will use microPET for the in vivo quantification of 18F-UCB-H brain uptake in 16 wild type animals and 16 transgenic (Tg) mice overexpressing human α–syn under the mThy1 promotor every 2 months. Data will be validated against post-mortem analyses after the last PET study. Predictions We predict decreased tracer uptake over time in the basal ganglia and cerebral cortex in Tg mice as compared with WT animals. Also, we predict a relationship between 18F-UCB-H uptake levels in basal ganglia and cerebral cortex and progressive alterations in both motor and cognitive functions, respectively. Further, we also expect that chronic exercise will slow down both motor and cognitive disturbances, as well as the rate of 18F-UCB-H brain uptake decreases. Conclusion If 18F-UCB-H PET proves to be a valid biomarker for the early detection of α–synuclein accumulation in the pre-clinical model of PD, the methods will tested on human clinical populations. [less ▲]

Detailed reference viewed: 124 (21 ULg)
See detailOncologie et revalidation physique
Leclerc, Anne-France ULg; Foidart-Dessalle, Marguerite ULg; COUCKE, Philippe ULg et al

in Abstract Book du Colloque "Femmes et Santé" (Université d'Hiver) (2015, January 26)

Le cancer constitue une maladie fréquente en Belgique puisqu'un homme sur trois et une femme sur quatre sont confrontés à la maladie avant l'âge de septante-cinq ans (Fondation Registre du Cancer, 2008 ... [more ▼]

Le cancer constitue une maladie fréquente en Belgique puisqu'un homme sur trois et une femme sur quatre sont confrontés à la maladie avant l'âge de septante-cinq ans (Fondation Registre du Cancer, 2008). La détection précoce et l'amélioration des traitements du cancer, généralement une combinaison de chirurgie, radiothérapie, chimiothérapie, hormonothérapie et thérapie ciblée, ont permis une augmentation du taux de survie. Cependant, ces traitements peuvent être à l'origine de nombreux effets secondaires, non seulement précoces, mais également tardifs, réduisant la qualité de vie. De nombreux programmes de réhabilitation après cancer sont basés sur la psychothérapie et le support social uniquement, or ceux-ci n'agissent généralement pas sur les problèmes physiques encourus par les patients tels que la fatigue, la prise de poids et la diminution des capacités fonctionnelles. C'est pourquoi nous émettons l'hypothèse qu'une revalidation physique, associée à des séances psycho-éducatives et constituant ainsi une prise en charge multidisciplinaire, permettrait d'améliorer d'autant plus la qualité de vie et le bien-être tant physique que psychologique des patients ayant été traités pour un cancer. [less ▲]

Detailed reference viewed: 37 (12 ULg)
Full Text
See detailREQUACARTO : outil d'aide à l'échantillonnage et au conseil de fumure
Renneson, Malorie ULg

Conference (2015, January 23)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailDesign Space for Analytical Methods: Why ? What ? How ?
Rozet, Eric ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

Conference (2015, January 22)

Detailed reference viewed: 22 (1 ULg)
Peer Reviewed
See detailEpidémiologie de la lithiase urinaire
Castiglione, Vincent ULg; GADISSEUR, Romy ULg

Conference (2015, January 22)

Description de l'épidémiologie de lithiase urinaire en Province de Liège, comparaison avec différents pays (France, USA), études récentes, explications sur des facteurs de risque.

Detailed reference viewed: 12 (2 ULg)
Peer Reviewed
See detailÉtude du Typus mélancholicus au sein d’une population de dépressifs unipoalires
ramackers, Amélia; Englebert, Jérôme ULg

Poster (2015, January 21)

Detailed reference viewed: 16 (0 ULg)
Peer Reviewed
See detailÉtude du récit de vie de l’adulte à haut potentiel
Mormont, Elodie; Gauthier, Jean-Marie ULg; Englebert, Jérôme ULg

Poster (2015, January 21)

Detailed reference viewed: 110 (9 ULg)
Peer Reviewed
See detailLa personnalité Borderline à travers le test de Rorschach
Rommes, Jennifer; Englebert, Jérôme ULg

Poster (2015, January 21)

Detailed reference viewed: 36 (2 ULg)
Full Text
See detailStatistical analysis of the quasi-periodic relativistic electron injections in the Saturn's magnetosphere
Palmaerts, Benjamin ULg; Roussos, Elias; Krupp, Norbert et al

Conference (2015, January 21)

Detailed reference viewed: 22 (6 ULg)