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See detailObservational signatures of past mass-exchange episodes in massive binaries: The cases of HD 149 404 and HD 17505
Raucq, Françoise ULg; Rauw, Grégor ULg; Gosset, Eric ULg et al

Conference (2015, November 30)

Mass and momentum exchanges in close massive binaries play an important role in the evolution of such systems and produce several observational signatures, such as asynchronous rotation and altered ... [more ▼]

Mass and momentum exchanges in close massive binaries play an important role in the evolution of such systems and produce several observational signatures, such as asynchronous rotation and altered chemical compositions, that remain once the stars detach again. We have started to investigate these effects for a sample of detached massive O-star binaries that are thought to have previously experienced a Case A Roche Lobe Overflow. Using phase-resolved spectroscopy, we perform the disentangling of the spectra of the two stars. The reconstructed primary and secondary spectra are then analyzed to determine a range of stellar effective temperatures and gravity, and rotational velocities. Using model atmosphere codes we also constrain the chemical composition of the components. In this contribution, we present the results of our analyses of HD149404 (O7.5If + ON9.5I, P = 9.81 days) and the first results of our analyses of HD17505 ([O7.5V + O7.5V, P = 8.57 days] + O6.5III). [less ▲]

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See detailLe concept de réserve cognitive
Grotz, Catherine ULg; Adam, Stéphane ULg

Conference (2015, November 30)

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See detailLipid metabolism in tumorigenesis and adaptation to cancer therapy
Sounni, Nor Eddine ULg

Conference (2015, November 27)

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See detailSaint Paul 3D - Acquisition tridimensionnelle de la cathédrale via LaserScan
Hallot, Pierre ULg

in Journée d'étude organisée par l'Institut du Patrimoine Wallon et le Comité Patrimoine et Histoire de la FABI (2015, November 27)

Les nouvelles techniques LiDAR (Light Detection and Ranging) et photogrammétriques permettent d’acquérir rapidement un volume important de données 3D. Le terme LiDAR désigne tout instrument de mesure ... [more ▼]

Les nouvelles techniques LiDAR (Light Detection and Ranging) et photogrammétriques permettent d’acquérir rapidement un volume important de données 3D. Le terme LiDAR désigne tout instrument de mesure (terrestre, aéroporté) basé sur l’analyse des propriétés d’un faisceau renvoyé vers un émetteur (Poux et al. 2014). Conscient de l’énorme potentiel de ces techniques, l’Unité de Géomatique de l’Université de Liège a réalisé la numérisation de la Cathédrale Saint‐Paul de Liège. Ce projet a été initié via une collaboration avec le Matthieu Piavaux (FUNDP) et financée par le FNRS. Au‐delà des aspects de conservation et d’analyse du bâti, cette numérisation nous a permis de mettre en lumière les principes et limitations de la technique même d’acquisition de données 3D via LiDAR ainsi que ses limitations tant matérielles (sur terrain) que logicielles (traitement des données). Le jeu de donnée obtenu de la numérisation sert également de base fondamentale à un ensemble de projets de recherches (notamment via la réalisation de thèses de doctorats) visant à la segmentation automatique de nuages de points, de reconstruction d’objets tridimensionnelles, d’analyse de qualité d’ajustements. Par la suite, nous détaillons la méthodologie utilisée pour l’acquisition du nuage de points 3D ainsi que les différents principes de calage de nuages. Le chapitre suivant sera consacré à la présentation de résultats ainsi que de premiers développements en termes de segmentation automatique. Finalement, nous dresserons quelques perspectives de représentations. [less ▲]

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See detailEntrer, rester ou partir : la question des vocations sous la plume d’écrivaines cloîtrées (XVIIe-XVIIIe s.)
Henneau, Marie-Elisabeth ULg

Conference (2015, November 27)

Les récits de fondation élaborés par bon nombre de communautés religieuses féminines et souvent prolongés par des chroniques, annales et abrégés de vertus jusqu’à leur suppression offrent de riches ... [more ▼]

Les récits de fondation élaborés par bon nombre de communautés religieuses féminines et souvent prolongés par des chroniques, annales et abrégés de vertus jusqu’à leur suppression offrent de riches possibilités d’analyses des questions relatives aux vocations et à la représentation que s’en font ou que veulent en donner celles et ceux qui en sont les auteurs. Loin de ne recenser que les itinéraires les plus « linéaires », quantité de textes évoquent les destins contrariés et les changements de cap et proposent leur propre interprétation des motifs qui ont justifié les demandes – d’entrée ou de sortie – des unes et les réponses – acceptation ou refus – des autres. On se propose de prendre ici en compte des textes inédits produits par des religieuses contemplatives (annonciades, bernardines et bénédictines) dont les maisons se sont implantées ou réformées au XVIIe siècle en Franche-Comté, en Lorraine et aux Pays-Bas méridionaux – sur une « dorsale catholique » faisant face aux mondes protestants –, que l’on confrontera aux normes propres à leur institut et aux règlementations des pouvoirs civils et religieux des territoires concernés. On tentera d’analyser tout d’abord comment s’énonce la vocation de femmes qui souhaitent, dans ce contexte particulier, défendre leur choix de vie contemplative face aux exigences ou aux objections des autorités compétentes. On suivra l’évolution de leur argumentation depuis le temps où elles tentent de développer leur institut jusqu’au moment où elles doivent en défendre les fondements en réponse aux projets de sécularisation ou de suppression. On abordera ensuite la question des vocations individuelles en examinant comment les annalistes relatent et interprètent les motivations spirituelles mais aussi sociales et économiques des postulantes (et de leur entourage) et expliquent longuement les raisons des éventuels renvois ou sorties (aptitudes intellectuelles et physiques, traits de caractère, divergences de vue avec la communauté, pressions familiales...). On analysera les nombreuses protestations de fidélité aux règles des fondateurs concernant les conditions d’admission, mais aussi les justifications avancées par les intéressées quand il s’agit de les adapter ou d’y déroger. On examinera encore comment les autrices perçoivent la question des vocations forcées et critiquent la société qui en serait responsable. Enfin, on tentera de voir comment ces femmes réagissent face aux mesures prises par les autorités civiles pour surveiller et limiter leurs possibilités de recrutement. Dans un troisième temps, on examinera brièvement quelques cas de demandes de sortie temporaire ou définitive (au départ d’une enquête documentaire plus vaste) dont on tentera de percevoir l’écho – réprobateur ou compréhensif – dans les récits de celles qui restent. [less ▲]

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See detailEvaluation clinique des états de conscience altérée
VANHAUDENHUYSE, Audrey ULg

Conference (2015, November 26)

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See detailForward Stagewise Additive Modeling for Computer Aided Diagnosis (CAD) Systems
Wehenkel, Marie ULg

Poster (2015, November 26)

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See detailAu-delà de l'ironie, le faux documentaire à l'épreuve des violences sexuelles.
Hamers, Jérémy ULg

Conference (2015, November 26)

Detailed reference viewed: 32 (6 ULg)
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See detailParameter Correlation Analysis in Four Mathematical Models of Left Ventricular Relaxation
Pironet, Antoine ULg; MORIMONT, Philippe ULg; Dauby, Pierre ULg et al

in Proceedings of the IEEE-EMBS Benelux chapter 2015 meeting (2015, November 26)

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See detailEstimation de spectres de singularités par des techniques de grandes déviations basées sur les ondelettes
Esser, Céline ULg

Conference (2015, November 26)

La régularité en un point d'une fonction peut être caractérisée par son exposant de Hölder. Si la fonction est très irrégulière, celui-ci peut varier fortement d'un point à l'autre. Dans ce cas, il est ... [more ▼]

La régularité en un point d'une fonction peut être caractérisée par son exposant de Hölder. Si la fonction est très irrégulière, celui-ci peut varier fortement d'un point à l'autre. Dans ce cas, il est naturel d'étudier la distribution des exposants de Hölder: cette information est donnée par le spectre de singularités de la fonction. En général, ce spectre est assez difficile à calculer et on utilise des méthodes pour l'estimer. Plusieurs méthodes basées sur la décomposition en ondelettes ont été proposées ; elles reposent sur une caractérisation de l'exposant de Hölder par les coefficients d'ondelettes. Dans cet exposé, nous introduisons une nouvelle technique reposant sur des estimations de grandes déviations basées sur les coefficients d'ondelettes et montrons son efficacité sur plusieurs exemples [less ▲]

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in Proceedings of the IEEE-EMBS Benelux chapter 2015 meeting (2015, November 26)

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See detailLes marqueurs biologiques de l'arthrose : de la conception à la qualification
Henrotin, Yves ULg

Conference (2015, November 26)

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

Poster (2015, November 26)

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See detailIndustrial Biological Chemistry laboratory activities
Jacquet, Nicolas ULg; Richel, Aurore ULg

Conference (2015, November 26)

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See detailIndustrial Biological Chemistry laboratory activities (GxABT-CBI)
Jacquet, Nicolas ULg

Conference (2015, November 26)

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See detailMiombo Woodlands : an endangered forest ecosystem in periurban areas of the southeastern cities of Democratic Republic of Congo
Hick, Aurélie ULg; Kizila Wimana, Pacifique; Tooth, Martin et al

Poster (2015, November 26)

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See detailBiomass and carbon stocks of tropical African forests: synthesis and perspectives
Loubota Panzou, Grâce Jopaul ULg; Doucet, Jean-Louis ULg; Loumeto, Jean-Joël et al

Poster (2015, November 26)

Quantifying the biomass and carbon stocks contained in tropical forests has become an international priority for the implementation of the REDD+ mechanism. Forest biomass is estimated through three ... [more ▼]

Quantifying the biomass and carbon stocks contained in tropical forests has become an international priority for the implementation of the REDD+ mechanism. Forest biomass is estimated through three successive levels: the tree, the stand and the region level. This study reviews the state of the art on the estimation of biomass and carbon stocks contained in tropical African forests. This review highlights that only few allometric equations, equations used for estimating biomass of the tree from non-destructive measurements (diameter, height), have been established for tropical African forests. At the stand level, this synthesis highlights the spatial and temporal variations in biomass between forests types in Central and Eastern Africa. While biomass recovery after disturbance (logging for instance) is rather quick, there is still a lot of uncertainity on the spatial variation in biomass, and there is no consensus on a regional biomass map. The quality of biomass mapping in tropical Africa stronly depends on the various sensors used (optical, RADAR or LIDAR), the allometric equation used to convert forest inventory data and sampling design. Based on the lack of precision of available allometric equations and forest inventory data a large spatial scale, many uncertainties persist on estimating the biomass and carbon stocks contained in the African tropical forests. It is important to develop reference sites (both allometry and forest inventory) to provide accurate biomass estimates for an effective implementation of the REDD+. [less ▲]

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See detailUltraviolet auroral emissions on giant planets
Grodent, Denis ULg; Bonfond, Bertrand ULg; Radioti, Aikaterini ULg et al

Conference (2015, November 25)

The aurorae on Jupiter and Saturn are the most powerful proper ultraviolet emissions in our solar system, after the Sun’s. They can only be observed outside the absorbing atmosphere of the Earth with ... [more ▼]

The aurorae on Jupiter and Saturn are the most powerful proper ultraviolet emissions in our solar system, after the Sun’s. They can only be observed outside the absorbing atmosphere of the Earth with space telescopes such as the Hubble Space Telescope or the Hisaki Telescope, or from Spacecraft orbiting these planets, like Cassini for Saturn and Juno for Jupiter. We will review the types of observation that can be obtained with these different instruments and how this information can be used to interpret the auroral emissions. [less ▲]

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See detailÉconomie sociale et fiscalité: état des lieux et perspectives
Garroy, Sabine ULg

Conference (2015, November 25)

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See detailComparing photogrammetry and laser scanning: a 3D reconstruction of the Castle of Penne
Novel, Cyril; Keriven, Renaud; Poux, Florent ULg et al

Conference (2015, November 25)

In the last decade, the progress in computing power – both CPU and GPU – has allowed the development of photogrammetry softwares. These softwares can turned a set of photos of an object – such as a ... [more ▼]

In the last decade, the progress in computing power – both CPU and GPU – has allowed the development of photogrammetry softwares. These softwares can turned a set of photos of an object – such as a building – into a 3D model. They compete with laser scanners which are usually used for scanning objects like buildings and landmarks. In this paper, we compare outcomes of the software Smart3DCapture[4] with laser scanner point clouds of various scenes in order to evaluate the accuracy of photogrammetry reconstruction [less ▲]

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See detailTrajet de soins et patient traceur pour la culture de qualité des soins et de sécurité des patients au CNRF.
BASSLEER, Bernard ULg; Jeunehomme, Laura; Guillaume, Daniel et al

Poster (2015, November 24)

Exposé méthodologique pour augmenter la culture organisationnelle de la qualité des soins dans un contexte d'accréditation hospitalière.

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See detailL’Entéropathie Epizootique des lapins : passé, présent et futur
Marlier, Didier ULg

in ITAVI (Ed.) Proceedings des 16èmes journées de la recherche cunicole (2015, November 24)

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See detailA Lightweight Network Proximity Service Based On Neighborhood Models
Liao, Yongjun; Du, Wei; Leduc, Guy ULg

in 22nd IEEE Symposium on Communications and Vehicular Technology in the Benelux (SCVT) (2015, November 24)

This paper proposes a network proximity service based on the neighborhood models used in recommender systems. Unlike previous approaches, our service infers network proximity without trying to recover the ... [more ▼]

This paper proposes a network proximity service based on the neighborhood models used in recommender systems. Unlike previous approaches, our service infers network proximity without trying to recover the latency between network nodes. By asking each node to probe a number of landmark nodes which can be servers at Google, Yahoo and Facebook, etc., a simple proximity measure is computed and allows the direct ranking and rating of network nodes by their proximity to a target node. The service is thus lightweight and can be easily deployed in e.g. P2P and CDN applications. Simulations on existing datasets and experiments with a deployment over PlanetLab showed that our service achieves an accurate proximity inference that is comparable to state-of-the-art latency prediction approaches, while being much simpler. [less ▲]

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See detailDémarche participative des patients et Comité de patients au CHU de Liège.
BASSLEER, Bernard ULg; BOULANGER, Jean-Marie ULg; DOPPAGNE, Caroline ULg

Poster (2015, November 24)

Des éléments tels que l’évolution socio-économique, l’évolution des soins, la généralisation de l’accès à l’information pour le patient, les attentes des patients, la parution de différents articles de ... [more ▼]

Des éléments tels que l’évolution socio-économique, l’évolution des soins, la généralisation de l’accès à l’information pour le patient, les attentes des patients, la parution de différents articles de loi (en particulier la loi sur les droits du patient et certaines recommandations de l’OMS) amènent une évolution dans le rapport entre les soignants et les patients. La médecine évolue peu à peu vers un modèle de médecine participative. [less ▲]

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See detailTime-lapse inversion of ERT monitoring data using variogram-based regularization
Hermans, Thomas ULg; Dumont, Gaël ULg; Kemna, Andreas et al

Conference (2015, November 24)

Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active ... [more ▼]

Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active processes in subsurface reservoirs. Time-lapse inversion schemes have been developed to refine inversion results; but, in contrast with static inversion, they mostly still rely on the spatial regularization procedure based on the standard smoothness constraint. In this contribution, we propose to apply a variogram-based regularization operator in the time-lapse ERT inverse problem, using the model difference covariance matrix to replace the standard smoothing operator. The variogram of resistivity variations can be computed through independent borehole data, such as electromagnetic logs or hydrogeological monitoring, which is often available during monitoring experiments. We first illustrate the method for surface ERT with a synthetic case and compare the results with the standard smoothness constraint solution. This example shows that the variogram-based constraint images better the assumed anomaly both in terms of shape and amplitude. The improvement is largely higher than the one obtained with more classical anisotropic smoothness constraint. This synthetic example also shows that an error made in the range of the variogram has a limited impact on the resulting image, which still remains better than the smoothness constraint result. Anomalies located in various part of the tomograms were tested. Although more crucial in low-sensitivity zones, improvements are observed everywhere in the tomograms. The method is then applied to cross-borehole ERT field data from a heat tracing experiment, where the comparison with direct temperature measurements shows a strong improvement of the breakthrough curves retrieved from ERT. Using the variogram-based regularization, it is possible to reduce the smoothing of resistivity variations in low sensitivity zones and therefore to avoid overestimation of temperatures. The proposed method could be extended to the time dimension which would allow the use of variogram-based constraints in 4D inversion schemes. [less ▲]

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See detailEnquête ethnographique sur les processus de (dé)subjectivation dans l’activisme associatif
Borotto, Jessica ULg; Duysens, Fanny ULg

Conference (2015, November 24)

L’activisme associatif dans le domaine de la déficience intellectuelle a connu des évolutions significatives depuis quelques décennies. Suivant les principes fondateurs de la Convention des Nations Unies ... [more ▼]

L’activisme associatif dans le domaine de la déficience intellectuelle a connu des évolutions significatives depuis quelques décennies. Suivant les principes fondateurs de la Convention des Nations Unies relative aux droits des personnes handicapées (2006), les associations de personnes concernées revendiquent leur légitimité à s’impliquer activement dans la gouvernance des questions qui les concernent. Cette communication porte sur les manières dont de jeunes adultes dits porteurs de déficience intellectuelle sont sujets à des processus de subjectivation et de désubjectivation au travers de discours et pratiques associatives qui revendiquent leur pleine inclusion et participation à la société. Croisant nos recherches respectives en sciences sociales et en philosophie politique, nous mobilisons une approche du sujet observé en situation (Agier, 2012) en vue d'envisager des « scènes de subjectivation » formelles et informelles dans le cadre d'une association belge francophone, en ce qu’elles nous semblent effectivement donner à voir de telles dynamiques de (dé)subjectivation par lesquelles se (re)construisent constamment les sujets porteurs de déficience intellectuelle et leur capacité d’agir. [less ▲]

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See detailMultimedia-enhanced learning productions - A typology based on instructional use and needed resources
Van de Poël, Jean-François ULg; Martin, Pierre; Verpoorten, Dominique ULg

Poster (2015, November 24)

This poster introduces a typology of educational multimedia objects stemming from an analysis of 400 audiovisual items produced by IFRES-eCampus, the staff development unit of the University of Liège ... [more ▼]

This poster introduces a typology of educational multimedia objects stemming from an analysis of 400 audiovisual items produced by IFRES-eCampus, the staff development unit of the University of Liège (Belgium). The classification of the multimedia productions is based on their instructional use and is enriched by additional qualifications in terms of time investment by the faculty and the Teaching and Learning center. [less ▲]

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See detailUne approche pour l'amélioration de la qualité au CHU de Liège.
LASRI, Saadia ULg; BASSLEER, Bernard ULg

Poster (2015, November 24)

Présentation du concept de déclaration informatisée d'événement indésirable.

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See detailCaractérisation des propriétés hydrauliques de sols caillouteux
Pichault, Mathieu; Garré, Sarah ULg

Conference (2015, November 24)

La détermination des propriétés hydrauliques du sol est une préoccupation majeure dans différents domaines d’études. Bien que les sols caillouteux soient répandus dans le monde entier, la plupart des ... [more ▼]

La détermination des propriétés hydrauliques du sol est une préoccupation majeure dans différents domaines d’études. Bien que les sols caillouteux soient répandus dans le monde entier, la plupart des études ne caractérisent que la fraction fine des sols, si bien que la littérature décrivant l’impact des cailloux sur les propriétés hydrauliques du sol est encore rare. Certains modèles ayant pour but de caractériser ces propriétés hydrauliques reposent sur la même hypothèse simplificatrice, qui stipule que le seul effet des cailloux est de diminuer le volume disponible pour l’écoulement de l’eau. L’objectif de cette étude est de vérifier cette hypothèse et, le cas échéant, d’identifier les facteurs déterminant ou non son respect. L’effet des cailloux sur la conductivité hydraulique à saturation effective du sol a été testé au moyen d’expériences de laboratoire et d’expériences numériques, impliquant différentes quantités et types de fragments grossiers. Nos résultats montrent que plusieurs facteurs supplémentaires, non considérés par ces modèles, peuvent affecter significativement la conductivité hydraulique à saturation. D’une part, la forme et la taille des inclusions altèrent de manière substantielle la conductivité hydraulique. D’autre part, la présence de cailloux peut contrer -voire dominer- les effets liés à la réduction du volume disponible pour l’écoulement en conditions saturantes. Nous attribuons cela à la création de macropores à l’interface entre la terre fine et les cailloux. [less ▲]

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See detailPIV-based estimation of unsteady loads on a flat plate at high angle of attack using momentum equation approaches
Guissart, Amandine ULg; Bernal, Luis; Dimitriadis, Grigorios ULg et al

Conference (2015, November 23)

The direct measurement of loads with force balance can become challenging when the forces are small or when the body is moving. An alternative is the use of Particle Image Velocimetry (PIV) velocity ... [more ▼]

The direct measurement of loads with force balance can become challenging when the forces are small or when the body is moving. An alternative is the use of Particle Image Velocimetry (PIV) velocity fields to indirectly obtain the aerodynamic coefficients. This can be done by the use of control volume approaches which lead to the integration of velocities, and other fields deriving from them, on a contour surrounding the studied body and its supporting surface. This work exposes and discusses results obtained with two different methods: the direct use of the integral formulation of the Navier-Stokes equations and the so-called Noca's method. The latter is a reformulation of the integral Navier-Stokes equations in order to get rid of the pressure. Results obtained using the two methods are compared and the influence of different parameters is discussed. The methods are applied to PIV data obtained from water channel testing for the flow around a 16:1 plate. Two cases are considered: a static plate at high angle of attack and a large amplitude imposed pitching motion. Two-dimensional PIV velocity fields are used to compute the aerodynamic forces. Direct measurements of dynamic loads are also carried out in order to assess the quality of the indirectly calculated coefficients. [less ▲]

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See detailLa subjectivité au dehors : du Saint Genet à la Conférence de Rome
Caeymaex, Florence ULg

Conference (2015, November 23)

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See detailWho are my Visitors and Where do They Come From? An Analysis Based on Foursquare Check-ins and Place-based Semantics.
Hallot, Pierre ULg; Stewart, Kathleen; Billen, Roland ULg

in Eurographics Workshop on Urban Data Modelling and Visualisation 2015 (2015, November 23)

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This ... [more ▼]

Activity recommendation systems aims at providing relevant information depending on targeted users' groups. For instance in a city, it makes sense to differentiate local residents from tourists. This research investigates to what extent the anonymized data collected from social networks can be used as a basis for making activity recommendations associated with local residents versus tourists when visiting a public place, such as a museum or gallery. Using rules based on the spatial, temporal and semantics of visited places, we are able to infer if a user is likely to be local or a tourist, based on anonymous sample Foursquare data and place-based semantics retrieved using Google Places API. Using semantics of visited places, it becomes possible to infer additional information about a user based on their movements over space and time. Depending on the kind and frequency of visited places, inferences about the aim of a visit to a location are possible. This analysis could provide information to users in the form of recommendations based on their movements while travelling around an area. This study has been performed using Foursquare check-ins for visitors to the Art Institute of Chicago between March 2010 and January 2011. [less ▲]

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See detailUNRAVELLING THE ROLES OF LYSINE ACETYLATION BY ELP3 DURING INNER EAR DEVELOPMENT
Mateo Sanchez, Susana ULg; Delacroix, Laurence ULg; Freeman, Stephen ULg et al

Poster (2015, November 23)

We planned to investigate the role of Elp3 acetyl-transferase, a member of the Elongator complex, in inner ear formation. We first analysed the spatio-temporal pattern of Elp3 mRNA expression and showed ... [more ▼]

We planned to investigate the role of Elp3 acetyl-transferase, a member of the Elongator complex, in inner ear formation. We first analysed the spatio-temporal pattern of Elp3 mRNA expression and showed that it was expressed in the entire early otocyst at E11.5 and persisted later in the sensory epithelium of the cochlea, in the spiral ganglion and in the vestibule. To unravel functions of Elp3, we used conditional knock-out mice in which Elp3 gene is deleted from early otocyst (Elp3cKO). We submitted these mice to a battery of vestibular testing and found significant abnormalities. Besides, the auditory brain stem response of Elp3cKO indicated that these mice are severely deaf. We were also able to demonstrate an increased level of apoptosis in the Elp3cKO spiral ganglion leading to a reduced number of neurons and fibers innervating the sensory cells as well as a reduced number of their synaptic ribbons. Moreover, the remaining spiral ganglion neurons extend processes showing clearly defects regarding sensory cell innervation. In conclusion, our results clearly show a role for Elp3 both in hearing and balance. We plan to go deeper in the mechanisms involved through the identification of the proteins that are targeted for acetylation by Elp3. [less ▲]

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See detailThe mysterious droplet birth in a microfluidic cross junction
Van Loo, Stéphanie ULg; Gilet, Tristan ULg

Conference (2015, November 23)

In microfluidics flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. Nevertheless, the scaling laws associated to droplet length, speed and frequency could ... [more ▼]

In microfluidics flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. Nevertheless, the scaling laws associated to droplet length, speed and frequency could not be identified yet, owing to the large number of parameters involved (incl. complex geometry). We here present an experimental study of droplet formation in a microfluidic cross-junction with a minimum number of geometrical parameters. We mostly focus on the dripping regime. The formation sequence is decomposed in two steps, inflation and squeezing, that vary differently according to both water and oil flow rates. These variations reveal several insights about the fluid flows in both phases. From there we infer the scaling law that relates droplet volume and frequency to the Capillary number associated to each inlet flow rate. This law involves a minimum of fitting parameters. We finally discuss the influence of inlet control (flow rate vs. pressure) and surfactants on the formation dynamics. [less ▲]

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See detailEffects of Plant Growth-Promoting Rhizobacteria on Wheat Growth under Greenhouse and Field Conditions in combination with different nitrogen fertilizer levels
Nguyen, Minh ULg; Ongena, Marc ULg; Colinet, Gilles ULg et al

Poster (2015, November 23)

Many Plant Growth-Promoting Rhizobacteria (PGPR) are able to enhance root growth, mineral availability, and nutrient use efficiency of crops. The aim of this project is to screen commercially available ... [more ▼]

Many Plant Growth-Promoting Rhizobacteria (PGPR) are able to enhance root growth, mineral availability, and nutrient use efficiency of crops. The aim of this project is to screen commercially available PGPR formulations and lab strains to increase wheat growth and yield in combination with an optimized nitrogen (N) fertilizer application scheme. This could lead to a significant reduction of N fertilizer application without affecting the subsequent grain yields. The screened products collection includes (1) Mix1 (a mix of Azospirillum sp., Azorhizobium sp., and Azoarcus sp.), (2) Mix2 (a mix of Mix1 complemented with two strains of phosphorus-solubilizing Bacillus sp.), (3) Bacillus amyloliquefaciens a, (4) B. subtilis, and (5) B. amyloliquefaciens b. These products were screened under greenhouse and field conditions in 2014 by using spring and winter wheat varieties, respectively. Under greenhouse conditions, there was a significant increase in root dry weight and in root per shoot ratio of plants inoculated with Mix1. Under field conditions, the interaction between PGPR inoculation and different N fertilizer doses was assessed. The grain yield was negatively impacted by low N fertilizer applications. Under such conditions, the inoculation of the wheat rhizosphere with B. subtilis increased the grain yield by 15% relative to the water control. However, in the field trial, the variability between plot replicates was high and lead to non-significant results. Based on these results, modified screening strategies for PGPR selection were set up for the next trials. [less ▲]

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See detailPegylated Polyplexes Based On HDAC5 siRNA And Aliphatic Polycarbonate Polymers For An Anticancer Therapy
Frère, Antoine ULg; Baroni, Alexandra; Peulen, Olivier ULg et al

Poster (2015, November 23)

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See detailSous le regard de Zeus Horios. Borner la terre en pays grec.
Lebreton, Sylvain ULg

Conference (2015, November 23)

La diversité des sources relatives aux horoi – limites, frontières, bornes – dans le monde grec antique est sans doute révélatrice de l'importance de la délimitation et du bornage de la terre aux yeux des ... [more ▼]

La diversité des sources relatives aux horoi – limites, frontières, bornes – dans le monde grec antique est sans doute révélatrice de l'importance de la délimitation et du bornage de la terre aux yeux des anciens Grecs. C'est la retranscription de cet enjeu multiforme – tant symbolique que matériel, politique qu'économique – dans le champ du polythéisme qui fera l'objet de cette présentation. Si l'on se borne aux puissances divines explicitement invoquées comme garantes de ces horoi, on constate qu'au sein d'un ensemble où l'on rencontre Apollon, Athéna, Héra, émerge incontestablement la figure du Zeus Horios. La mise en contexte et en série des données relatives au culte de ce dernier, ainsi que l'examen des logiques théologiques qui les soutiennent et les procédés rituels qui les accompagnent, formeront par conséquent le cœur de cette étude. Au-delà des possibilités d'expérimentation sur le fonctionnement du polythéisme hellénique qu'elle offre, cette étude de cas permettra, on l'espère, d'éclairer la manière grecque d'investir symboliquement la terre, en l'occurrence de justifier sur le plan religieux les délimitations appliquées à celle-ci. [less ▲]

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Peer Reviewed
See detailMarx atomism: critical use of Hegel’s logic against Hegel’s logic
Ghanbari Matin, Soheil ULg

Conference (2015, November 22)

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See detailDiachronic lexical semantics in Ancient Egyptian–Coptic: The Egyptianness of basic vocabulary in Coptic
Grossman, Eitan; Polis, Stéphane ULg

Conference (2015, November 21)

Coptic, as it comes down to us in written texts, is massively influenced by Greek in the domain of lexicon. The Leipzig-Berlin Dictionary and Database of Greek Loanwords in Coptic project has already ... [more ▼]

Coptic, as it comes down to us in written texts, is massively influenced by Greek in the domain of lexicon. The Leipzig-Berlin Dictionary and Database of Greek Loanwords in Coptic project has already recorded c. 5000 loan word types and c. 60.000 loan word tokens. On this basis, linguists, philologists, and historians often make assumptions about the nature and extent of bilingualism. Some linguists have even proposed that Coptic is a case of ‘code-mixing’ of Egyptian and Greek, which assumes extensive bilingualism among Egyptians in Late Antiquity. In this paper, we tackle this question from another angle, by determining the extent to which Greek influenced Coptic in terms of its *basic vocabulary*. It may be that we can learn more about bilingualism in Late Antique Egypt this way, since overall lexical borrowing need not correlate with lexical borrowing in the domain of basic vocabulary. As a (significant) side effect of this study, we can also describe the rate of replacement of basic vocabulary in Egyptian-Coptic across its 4000 years of attestation, as well as the semantic domains and periods in which lexical replacement was faster or slower. [less ▲]

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See detailLa sexualité au fil des âges: l'adolescence
Glowacz, Fabienne ULg; Loumaye, Sylvie

Conference (2015, November 21)

Detailed reference viewed: 21 (2 ULg)
See detailKDIGO a guidelines for bone turnover management in dialysis patients
CAVALIER, Etienne ULg

Conference (2015, November 20)

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See detailQue garder parmi les index de résistance à la fatigue?
Paulus, Julien ULg; Bosquet, Laurent; Gremeaux, Vincent et al

Conference (2015, November 20)

Objectif Les tests isocinétiques contribuent régulièrement à l'évaluation de la performance musculaire et en sont considérés comme un gold standard [1]. Les tests de fatigabilité peuvent s'avérer ... [more ▼]

Objectif Les tests isocinétiques contribuent régulièrement à l'évaluation de la performance musculaire et en sont considérés comme un gold standard [1]. Les tests de fatigabilité peuvent s'avérer complémentaires des épreuves courtes de force notamment pour évaluer un athlète sollicitant particulièrement la filière anaérobie lactique ou dans des contextes pathologiques spécifiques [2]. Bien que Bosquet et al. [3] aient démontré la reproductibilité d'un protocole de fatigabilité pour le genou, à notre connaissance, aucune étude, ayant pour objectif d'être exhaustive dans son analyse, n'a été menée sur la reproductibilité des paramètres mesurés (meilleure répétition, cumuls total et partiels) et index de fatigue (quotient des n dernières répétitions par les x premières, du cumul des répétitions par la meilleure,…). Ces index et paramètres mesurés sont néanmoins proposés directement par les dynamomètres, sans en connaître systématiquement la méthode de calcul, et/ou utilisés en clinique et dans la littérature pour caractériser la fatigabilité musculaire du genou [4]. Sont-ils cependant suffisamment reproductibles pour que leur utilisation soit scientifiquement validée? Matériel & méthode Dix-huit sujets, modérément actifs, ont réalisé trente extensions-flexions maximales du genou à trois occasions, avec sept à dix jours de repos entre chaque session. Le moment de force maximum (MFM) et le travail maximal (Wmax) de chaque répétition ont été enregistrés pour compiler onze paramètres mesurés et construire quarante-quatre index. La reproductibilité de chaque paramètre et index a été évaluée via leur ICC (2,1), SEM et MD respectifs. Résultats Les valeurs d'ICC des paramètres mesurés pour les extenseurs du genou sont quasi-systématiquement supérieures à 0.8 tandis que celles pour les fléchisseurs oscillent entre 0.7 et 0.8. Les valeurs d'ICC pour les "index de fatigue" construits sont inférieures à 0.7 et 0.5 respectivement pour les extenseurs et fléchisseurs. Aucune différence notable n'est observée entre la reproductibilité du MFM et celle du Wmax (que ce soit pour les extenseurs ou les fléchisseurs ou pour les paramètres mesurés et les "index de fatigue"). Discussion Au vu des valeurs obtenues sur notre population, il apparait qu'aucun index de fatigue calculé ne semble suffisamment reproductible pour une utilisation clinique ou scientifique! Seuls les paramètres mesurés tels que la meilleure répétition, le cumul total ou partiel présentent une reproductibilité qui peut être qualifiée de (très) haute voire excellente et sont donc utilisables en clinique ou en recherche pour caractériser la fatigabilité musculaire du genou. [less ▲]

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See detailL'ambiguïté de la médiation
Dethier, Baptiste ULg; Dubois, Christophe ULg

Conference (2015, November 20)

Qu’elle soit appréhendée comme un symptôme ou un remède, la médiation apparaît dans un contexte où les liens sociaux se recomposent, où les institutions traditionnelles (état, église, école, justice, etc ... [more ▼]

Qu’elle soit appréhendée comme un symptôme ou un remède, la médiation apparaît dans un contexte où les liens sociaux se recomposent, où les institutions traditionnelles (état, église, école, justice, etc.) sont questionnées et où la prise en compte des singularités devient la norme. Depuis près de quarante ans, de multiples fonctions et dispositifs dits « de médiation » prolifèrent dans le but affirmé de créer ou renouer des liens entre les individus. Pour ce faire, les processus communicationnels sont privilégiés, alternativement ou parallèlement à une approche autoritaire. « La » médiation, pratiquée dans différents champs (notre entrée empirique étant celle de la médiation scolaire), fait l’objet de nombreux discours (politiques, managériaux, professionnels, scientifiques, etc.) mais sa définition et sa mise en œuvre entraînent plusieurs difficultés. Son caractère indéfini ou multidéfini, flexible et malléable ouvre certes à une utilisation contextualisée, adaptée aux situations et aux individus. Mais ceci ouvre également à des interprétations et à des usages hétérogènes, parfois paradoxaux, et à des « débordements » pouvant menacer la légitimité des médiateurs et des dispositifs de médiation. Notre contribution vise par conséquent à rendre compte de l’ambiguïté constitutive des discours, des dispositifs et des pratiques de médiation scolaire, ceci afin d’en éclairer les ressources et les limites. [less ▲]

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See detailLa réception du national-socialisme dans les revues intellectuelles catholiques belges francophones (1933-1939)
Lanneau, Catherine ULg

Conference (2015, November 20)

French-speaking Belgian opinion on Nazi Germany can be seen through multiple lenses and very different focuses. We will analyze the main Catholic intellectual periodicals published between 1933 and 1939 ... [more ▼]

French-speaking Belgian opinion on Nazi Germany can be seen through multiple lenses and very different focuses. We will analyze the main Catholic intellectual periodicals published between 1933 and 1939, explaining our selection by a description of the weight of political Catholicism in the interbellum (("La Revue Générale", "La Revue Belge", "La Revue Catholique des Idées et des Faits", "La Cité Chrétienne", "La Terre Wallonne", "La Revue de l'Ordre Corporatif"). After reading six years of rather copious and often verbose articles, can we summarize and better define themes in their approach of Nazism? Are the articles studies in depth or are they merely floating on the surface, in spite of the amount of printed space occupied by them? Was Nazism seen as a new phenomenon, a form of New Order, or simply as a mere link in a continuous German history? Why is Hitler’s regime seen as perpetuating the Prussian State (and “Prussian” state of mind) or frowned upon as a conquering mystical or religious force applied to political expansion such as Islam had been? Which place is given to racist and völkisch views, to their contradiction with Christian ideals, to antisemitism? To which extent was Nazism rational or irrational, using empiricism or applying a spirit of system? Were the writers of 1933-1939 taking into account the social and economic reforms, the “progresses” accomplished, were they paying more than lip-service to the communitarian spirit of Volksgemeinschaft? [less ▲]

Detailed reference viewed: 33 (1 ULg)
See detail3rd Generation PTH: Clinical utility
CAVALIER, Etienne ULg

Conference (2015, November 20)

Detailed reference viewed: 18 (6 ULg)
See detailLiquidity patterns in the US corporate bond market
Heck, Stéphanie ULg; Margaritis, Dimitri; Muller, Aline ULg

Conference (2015, November 19)

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See detailL'Azacytidine comme traitement de la maladie du greffon contre l'hôte de type chronique sclérodermique expérimentale.
Fransolet, Gilles ULg; Ehx, Grégory ULg; SOMJA, Joan ULg et al

Conference (2015, November 19)

Introduction: Graft-versus-host disease (GVHD) has remained a major complication of allogeneic hematopoietic stem cell transplantation (HSCT) for the last decades. Following unmanipulated peripheral-blood ... [more ▼]

Introduction: Graft-versus-host disease (GVHD) has remained a major complication of allogeneic hematopoietic stem cell transplantation (HSCT) for the last decades. Following unmanipulated peripheral-blood stem cell transplantation, 60% of the patients experience chronic GVHD while approximately 15% of them develop a sclerodermic form of chronic GVHD characterized by multiple organ fibrosis and loss of skin elasticity. Regulatory T cells (Tregs) play a pivotal protective role in the pathogenesis of chronic GVHD by inhibiting alloreactive conventional T cells (Tconvs). Several studies have shown that hypomethylating agents such as azacytidine (Aza) can demethylate the master transcription factor of Treg (Forkhead box protein 3 factor, FoxP3), thus promoting Treg differentiation from Tconvs. This work investigates the impact of Aza in a classical murine model of sclerodermic chronic GVHD (B10.D2  BALB/cJ). Methods: In vitro analyses have been performed to determine the impact of Aza on collagen production. NIH-3T3 fibroblastic cells were plated and stimulated with 50 ng of PDGF or 10 ng of TGF-beta. Cells were then cultured with various concentrations of Aza for 48 hours. After culture, cells were stained with Sirius Red before quantification of collagen amount by absorbance at 490 nm. For in vivo experiments, lethally irradiated (7 Gy) BALB/cJ recipient mice were injected with 107 bone marrow cells + 7.107splenocytes from B10.D2 donor mice to induce scl-cGVHD. Recipients were injected with either 0,5 or 2 mg/kg of Aza every 48 hours from day 10 to 30 following transplantation. GVHD was scored using a five criteria scale (weight loss, activity, fibrosis, hair loss and mice posture; 0-1-2 points/criteria). Mice were sacrificed at a score of 8/10 (or > 20% weight loss) or at day 52 after transplantation (end of experiment). Results: Concerning in vitro analyses, results suggest a decreased production of collagen at higher concentration of Aza with both stimulations (seen by a gradual diminution of absorbance). For in vivo experiments, mice treated with Aza 0.5 mg/kg (n = 14) or 2 mg/kg (n = 25) had significant lower clinical scores of GVHD compared to control ones (n = 23) after treatment. FACS analysis showed a higher proportion of Treg among CD4+ T cells in the blood of Aza 2 mg/kg mice than in control mice at day 35 following transplantation (P = 0.047), as well as a higher percentage of Tregs expressing the KI67 proliferative marker on the same time point (P = 0.0005). Finally, analyses of the cellular blood components with Cell-dyn demonstrated that Aza 2 mg/kg treated mice were significantly lymphopenic as compared to control mice at day 35 after transplantation (P = 0.05). Conclusion : Aza prevented sclerodermic GVHD in this classical murine model of chronic GVHD. [less ▲]

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See detailMitigating the Nuclear ‘Dual-Use Dilemma’: Suggestions for the Enhancement of the Culture of Responsibility
Colussi, Ilaria Anna ULg

Conference (2015, November 19)

The speech aims at delineating a proper ethical and legal response to the ‘dual-use dilemma’ of nuclear science and technologies. After assessing the different models of governance proposed so far in ... [more ▼]

The speech aims at delineating a proper ethical and legal response to the ‘dual-use dilemma’ of nuclear science and technologies. After assessing the different models of governance proposed so far in nuclear field for addressing the ‘dual-use’ feature of nuclear technologies, and based on precautionary, proactionary or cost/benefit approaches, it suggests the adoption of a framework based on the notion of ‘responsible stewardship’. This model entails: (a) a constant analysis of nuclear technology, both on the side of risks and of benefits, through the involvement and cooperation of all the stakeholders in the field (the involvement of both ‘top down’ and ‘bottom up’ actors, i.e. governments and scientific community); (b) the adoption of policies through ‘hard law’ and ‘soft law’ sources, which should be periodically revised, and based on the proportionality principle and the reasonableness one (with a balance among rights and freedom, from a constitutional viewpoint); (c) an ongoing communication, dialogue and interaction between actors in the nuclear area. A specific attention is devoted to the balance between the freedom to research and the security needs. Then, the concrete ways for applying such model are explained, in particular with regards to the issue of control of materials, education of people, and control of information. Finally, the historical steps in the governance of nuclear technologies and the positions of different religions addressing the issue have been explored, in order to provide some examples of the suggested approach. [less ▲]

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Peer Reviewed
See detailParler pour soi-même dans un espace médiatique : les postures énonciatives dans le blog d'Ivan Rioufol
Servais, Christine ULg

Conference (2015, November 19)

A partir de l'analyse de l'énonciation dans le Blog d'Ivan Rioufol, je tente de mettre en évidence les caractéristiques politiques de ce discours, c'est-à-dire la manière dont il structure l'espace public ... [more ▼]

A partir de l'analyse de l'énonciation dans le Blog d'Ivan Rioufol, je tente de mettre en évidence les caractéristiques politiques de ce discours, c'est-à-dire la manière dont il structure l'espace public et la place qu'il y donne à son lecteur. Ce sont donc les effets politiques et policiers, au sens de Rancière, que j'y mets en évidence. [less ▲]

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See detailEmotional distress in Pediatric Cystic Fibrosis: using the Common-Sense Model of Self-Regulation to understand the role of illness perception and coping strategies
Toucheque, Malorie ULg; Stassart, Céline ULg; Duncan, Christina et al

Conference (2015, November 19)

Background: The common sense model of self-regulation (CSM) provides a framework for understanding the connection between emotions, thoughts and behaviors in people experiencing illness. However, most of ... [more ▼]

Background: The common sense model of self-regulation (CSM) provides a framework for understanding the connection between emotions, thoughts and behaviors in people experiencing illness. However, most of model in health psychology, including the CSM, were initially addressed to adult patients. Objective: This study examines the traditional conceptualization of the CSM where coping act as a mediator of the relation between illness perception and emotional distress in a pediatric population with chronic disease, namely Cystic Fibrosis (CF). Method: Using a cross-sectional design, 38 children with CF aged between 8 and 12 years participated in the study. All children were asked to complete: the State-Trait Anxiety Inventory for Children (STAIC), the Children’s Depression Inventory (CDI), the Kidcope and the Children’s Illness Perception Questionnaire (CIPQ). A composite score labelled “emotional distress” including scores of anxiety and depressive symptoms were created. Results: Illness perception predicted emotional distress (Timeline: β = .43; t = 2.835; p = .007; Consequences: β = .50; t = 3.429; p = .002; Control: β = .18; t = 1.088; p = .284). As regard with coping strategies, only emotional outburst and distraction predicted emotional distress (emotional outburst: β = .48; t = 3.241; p = .003; distraction: β = .32; t = 2.038; p = .049). However, there were no relation of illness perception subscales with emotional outburst and distraction. Therefore, the mediational role of coping strategies between illness perception and emotional distress could not be tested. Conclusion: Findings did not confirm the original conceptualization of coping as a mediator suggesting that the CSM needs to be adapted when applied with a pediatric population. Even though young children are able to think before acting (i.e. Piaget’s work), future research should explore the possibility that cognitions and actions exist at the same level and can independently impact adjustment outcomes. [less ▲]

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See detailCompensatory Metabolism Promotes Cancer Cell Adaptation to HDAC5 Silencing
Hendrick, Elodie ULg

Conference (2015, November 19)

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See detailÉtude comparative de nouveaux indices de détection de la réponse qui s’apparentent au hasard et à l’inattention
Béland, Sébastien; Raîche, Gilles; Magis, David ULg et al

Conference (2015, November 19)

Certains étudiants peuvent répondre au hasard ou être inattentifs dans une situation de testing. Plusieurs approches ont déjà été développées pour détecter ce type de réponse (Zickar et Drasgow, 1996 ... [more ▼]

Certains étudiants peuvent répondre au hasard ou être inattentifs dans une situation de testing. Plusieurs approches ont déjà été développées pour détecter ce type de réponse (Zickar et Drasgow, 1996). Parmi celles-ci, l’utilisation d’indices de détection de patrons de réponses inappropriés (person-fit indices) est l’approche qui est la plus étudiée et qui semble la plus prometteuse (Karabatsos, 2003; Meijer et Sijtsma, 2001). Dans le cadre de cette étude, nous nous concentrerons sur trois indices de détection populaires qui présentent des caractéristiques permettant d’en faciliter l’interprétation : lz (Drasgow, Levine et Williams, 1985), ZU (Wright et Masters, 1982) et ZW (Wright et Masters, 1982). Toutefois, il s’est avéré qu’ils sont tous fortement affectés par le fait que l’habileté d’un étudiant est estimée plutôt que réelle (Li et Olejnik, 1997; Molenaar et Hoijtink, 1990). Voilà pourquoi Snijders (2001) a proposé une version corrigée de l’indice lz (nommée lz*) qui prend en considération ce problème important. Nous avons déjà appliqué la correction de Snijders aux indices U et W en créant les indices ZU* et ZW* (Magis, Béland et Raîche, 2014). L’objectif de cette étude sera d’examiner le comportement des indices corrigés lz*, ZU* et ZW* et de leur version standardisée. Pour ce faire, nous effectuerons trois études différentes : une analyse descriptive des scores des indices, une analyse des erreurs de type I et une analyse de leur puissance de détection. Les analyses ont démontré que ce sont les indices corrigés lz* et ZW* qui sont les plus intéressants à utiliser puisque leurs scores suivent approximativement la loi N(0,1) et puisqu’ils permettent de bien détecter les réponses qui s’apparentent au hasard et à l’inattention. [less ▲]

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See detailNew technologies in Mycology: PCR for diagnosis
Hayette, Marie-Pierre ULg

Conference (2015, November 19)

Molecular biology techniques are widely used in mycology. First of all they are used for confirmation of difficult or uncertain identifications. In this case PCR followed by ITS sequencing is generally ... [more ▼]

Molecular biology techniques are widely used in mycology. First of all they are used for confirmation of difficult or uncertain identifications. In this case PCR followed by ITS sequencing is generally used. For diagnostic purposes, PCR is mostly applied for the detection of invasive infections such as pneumocystosis, candidosis or aspergillosis. However these techniques (Candida and Aspergillus detection) are still not included in the recommandations given by EORTC by lack of standardisation. However, the development of new commercially available techniques, will probably change the diagnostic algorithm. New commercial PCR kits applied to the detection of dermatophytes are also recently available to the laboratories and they will be a good complement to culture-based diagnostic methods. [less ▲]

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See detail5-Azacytidine and Rapamycin: different and synergistic effect on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULg

Conference (2015, November 19)

BACKGROUND: Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin ... [more ▼]

BACKGROUND: Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells OBJECTIVE: We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood. METHODS: CD4+CD25+ and CD4+CD25- T cells were isolated from PBMC of normal controls using Miltenyi beads and FACS ARIA sorting. These cells subsets were cultured in the presence of anti-CD3/CD28 antibodies and 200 IU/ml of IL2 for 2 weeks. RAPA (100nM) and 5-azaC (1µM) were added to half of the cultures. We monitored cell expansion and after harvest, the cell phenotype, gene expression, T suppression activity and Annexin V binding were determined and compared to values obtained with control cell culture and with freshly-separated CD4+CD25+ and CD4+CD25- T cells. Also we tested the absolute number of Treg in the several culture conditions during the time of expansion. RESULTS: We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. The addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. CONCLUSION: 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells. [less ▲]

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See detail"Matériau documentaire, expérimentation formelle : sur Release (2010) de Bill Morrison"
Belloi, Livio ULg

Conference (2015, November 19)

Cette communication se penche sur "Release" (2010), un film relativement peu connu du cinéaste américain Bill Morrison. Relevant du cinéma de found footage, cette œuvre retravaille une vue d'actualités ... [more ▼]

Cette communication se penche sur "Release" (2010), un film relativement peu connu du cinéaste américain Bill Morrison. Relevant du cinéma de found footage, cette œuvre retravaille une vue d'actualités tournée en 1930 aux abords du pénitencier de Philadelphie. Cette communication s'interroge sur les modalités (notamment : développement en miroir et mise en boucle) et les enjeux de cette reprise. [less ▲]

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See detailPhénologie des hêtres dans une forêt ardennaise: comparaison de méthodes de suivi et relations avec les flux de CO2
Hurdebise, Quentin ULg; Vincke, Caroline; De Ligne, Anne ULg et al

Poster (2015, November 18)

Bien caractériser la phénologie des essences forestières dans un contexte climatique changeant est indispensable. Dans cette optique, confronter les différentes sources d’informations phénologiques ... [more ▼]

Bien caractériser la phénologie des essences forestières dans un contexte climatique changeant est indispensable. Dans cette optique, confronter les différentes sources d’informations phénologiques (relevé de terrain, modélisation, capteurs de rayonnement, caméra phénologique, satellite, eddy covariance…) est une démarche essentielle. Les différences et la complémentarité de ces sources d’informations ont été mises en évidence en utilisant les données provenant d’une forêt mixte de l’Est de la Belgique, principalement composée de hêtres. Par ailleurs, ces informations ont été utilisées pour étudier l’influence de la phénologie des hêtres sur les échanges annuels de CO2 de ces derniers. [less ▲]

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See detailGoverning anticipation through flexibility. The use of models for the regulation of chemicals
Thoreau, François ULg; Laurent, Brice

Conference (2015, November 18)

As the use of models is increasing within regulatory bodies, it is important to grasp both the empirical practices of producing and using them, and their political meaning. At stake here is the ... [more ▼]

As the use of models is increasing within regulatory bodies, it is important to grasp both the empirical practices of producing and using them, and their political meaning. At stake here is the possibility of identifying the characteristics of a way of governing anticipations that would be based on models. In this paper, we engage in such an exploration by focusing on models developed to predict the potential risks of chemicals. These models, called “Quantitative Structure-Activities Relationship” (QSAR), are based on statistical correlations between a set of descriptors (e.g. chemical composition, crystalline structures…) and a set of physicochemical properties, including potential toxicity. They are developed using a limited number of substances that serve as reference points, so that the properties of other chemicals could later be predicted by the model, according to their proximities to the reference points. QSAR models have been promoted by regulatory agencies for over twenty years, but have been recently gaining momentum in Europe, in the wake of the REACH regulation. As the regulation on chemicals is becoming more constraining on private companies, usual experimental approaches raise many concerns (which are lengthy, costly and often requires animal testing). Based on the analysis of the relevant documentation, interviews with scientists and regulators, as well as the ethnographic observation of a recent research project attempting to developed QSAR models for nanomaterials, this paper provides the preliminary elements for describing the mode of governing anticipation that emerges from the use of such models. We contend that QSAR approaches offer empirical examples to identify a mode of governing anticipation based on flexibility, understood at the epistemic and political levels. [less ▲]

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See detailLa détection précoce de la maladie d'Alzheimer
Bastin, Christine ULg

Conference (2015, November 17)

Lorsque le diagnostic de maladie d’Alzheimer est posé, les atteintes au niveau du cerveau et l’ampleur des difficultés dans la vie quotidienne ont atteint un seuil critique. Actuellement, les chercheurs ... [more ▼]

Lorsque le diagnostic de maladie d’Alzheimer est posé, les atteintes au niveau du cerveau et l’ampleur des difficultés dans la vie quotidienne ont atteint un seuil critique. Actuellement, les chercheurs et les cliniciens pensent que pour tenter de retarder l’apparition d’une démence, voire même l’empêcher, il faut agir bien avant que les premiers symptômes majeurs apparaissent. Le défi actuel est de trouver les meilleurs outils permettant de détecter le plus tôt possible les premiers signes de la maladie. Etant donné que des changements cognitifs peuvent être détectés très tôt, les neuropsychologues tentent d’identifier parmi les tests qui forment le bilan neuropsychologique ceux qui permettent de prédire au mieux le développement futur d’une maladie d’Alzheimer. Les recherches ont suggéré que les mesures ayant le meilleur pouvoir de prédiction semblent être celles de mémoire épisodique (qui est la capacité à se souvenir d’événements vécus dans un contexte bien précis) et les mesures de fluence verbale (qui est la capacité à citer un grand nombre de mots appartenant à une catégorie ou commençant par une lettre donnée). Le groupe Vieillissement et Mémoire, au sein du Centre de Recherches du Cyclotron (Université de Liège), poursuit actuellement deux lignes de recherche en lien avec la question de la détection précoce de la maladie d’Alzheimer : Premièrement, nous tentons de déterminer si nous pouvons encore mieux détecter les personnes à risque de développer une maladie d’Alzheimer en affinant les mesures de la mémoire. Le point de départ de cette recherche doit être une compréhension approfondie des mécanismes qui régissent le fonctionnement de la mémoire ainsi que de leurs bases cérébrales. Nos premiers résultats ont montré une perte précoce de la capacité à réactiver tous les détails d’un épisode vécu, associée à une déconnexion entre les régions d’un réseau cérébral incluant le cortex cingulaire postérieur et l’hippocampe. Deuxièmement, nous étudions les facteurs protecteurs qui permettent à certaines personnes de mieux résister que d’autres aux effets négatifs du vieillissement et de la pathologie cérébrale. Une étude non encore publiée menée auprès de personnes âgées sans trouble cognitif a montré que plus les personnes avaient étudié longtemps et avaient pratiqué une activité physique au cours de leur vie, meilleure était leur capacité à se souvenir des détails des événements vécus. Enfin, une approche idéale pour Identifier le plus tôt possible qui risque de développer des symptômes de déclin cognitif est l’approche multidisciplinaire. Plutôt que d’évaluer l’intérêt d’une mesure seule, nous proposons de tenir compte de manière combinée des différents éléments qui semblent contribuer à la détection précoce de la maladie d’Alzheimer : modifications neuropathologiques, mesures neuropsychologiques, mesures de la structure et du fonctionnement cérébral, habitudes de vie, changements physiologiques et modification du sommeil. [less ▲]

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See detailComment améliorer la réussite à l'examen d'anatomie en 1ère année de bachelier en médecine? Etude de l'impact d'une activité intégrée dans un dispositif hybride de formation
Ernst, Denise ULg; SEIDEL, Laurence ULg; Defaweux, Valérie ULg et al

Poster (2015, November 17)

The course of “Introduction to Human Anatomy” is part of the curriculum delivered to the undergraduated students (Freshman year) at the Faculty of Medecine of the University of Liege. The course is taught ... [more ▼]

The course of “Introduction to Human Anatomy” is part of the curriculum delivered to the undergraduated students (Freshman year) at the Faculty of Medecine of the University of Liege. The course is taught in a blending learning mode combining traditional intructor-led and e-learning activities. The MCQ 2 test is one of the three components of the final written exam (which consists of 3 MCQ tests). This test requires students to recognize and identify the organ’s orientation in cross-sections represented in different spatial views. In our study, we tried to evaluate how the online training exercises provided by the instructors team for that particular ability was appreciated by students and if students benefited from this type of online activities to improve their examination results for MCQ 2 test. Further in our research, we asked student about their perceptions of coherence between the aims, methods and evaluation of our entire system. Then this perception has been compared with the overall score of the exam to look for the present of correlation elements. We observed that the MCQ 2 test results are significantly better for students who practiced the new online exercises and for students having seen the value of this activity. The perception of consistency or coherence between the objectives, methods and assessment is not correlated to the overall score of the student. As conclusion, we can declare that the new learning scenario proposed positively enriches the learning environment for students. It can be easily scaled up for important groups and accessed at any time by users. It focusses on specific objectives, is directly linked to the examination system of the course (MCQ 2) and also allows developing a competence expertise related to their future medical profession. [less ▲]

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See detailHow to circulate "population varieties" inside a locked seed system? Kaol Kozh's case
Hecquet, Corentin ULg

Conference (2015, November 17)

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See detailLes biomarqueurs de l'arthrose
Henrotin, Yves ULg

Conference (2015, November 17)

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See detailInsuffisance hépatique aigue: traitement conservateur et alternatives thérapeutiques
DETRY, Olivier ULg

Conference (2015, November 17)

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See detailLes urgences par traumatisme fermé ou ouvert de l'abdomen
DETRY, Olivier ULg

Conference (2015, November 17)

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See detailD'un Primo en local à un Primo dans le cloud: deux déploiements en deux ans d'une solution discovery à l'Université de Liège
Renaville, François ULg

Conference (2015, November 17)

En février 2013, les Bibliothèques de l'Université de Liège ont mis en production la solution discovery Primo, hébergée en local. Le projet s’est étalé sur une dizaine de mois, offrant ainsi aux ... [more ▼]

En février 2013, les Bibliothèques de l'Université de Liège ont mis en production la solution discovery Primo, hébergée en local. Le projet s’est étalé sur une dizaine de mois, offrant ainsi aux professionnels des Bibliothèques la possibilité de se familiariser avec le nouvel outil avant le lancement officiel. Moins d’un an plus tard, les Bibliothèques décidaient de passer au système de gestion de bibliothèque Alma, ce qui impliquait à nouveau le déploiement d’un Primo, cette fois-ci dans le cloud. En six mois, la migration vers Alma et le lancement de la nouvelle interface discovery étaient réalisés. Cette présentation balaye les moments clés des deux projets de déploiement Primo, en mettant l'accent sur la composante organisationnelle, la formation des équipes et la gestion du changement. [less ▲]

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See detailBien soigner l'arthrose: un enjeu capital pour notre société!
Henrotin, Yves ULg

Conference (2015, November 16)

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See detailLa guerre comme modèle des rapports de pouvoir. Question à Judith Butler
Caeymaex, Florence ULg

Conference (2015, November 16)

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See detailImpacts of Plant Growth-Promoting Rhizobacteria-based Biostimulants on Wheat Growth under Greenhouse and Field Conditions
Nguyen, Minh ULg; Ongena, Marc ULg; Colinet, Gilles ULg et al

Poster (2015, November 16)

Plant Growth-Promoting Rhizobacteria (PGPR) are one of the main biostimulant classes due to their capacity of stimulating root growth and enhancing soil mineral availability, hence increasing nutrient use ... [more ▼]

Plant Growth-Promoting Rhizobacteria (PGPR) are one of the main biostimulant classes due to their capacity of stimulating root growth and enhancing soil mineral availability, hence increasing nutrient use efficiency in crops. The aim of this study is to screen commercially PGPR-containing products to enhance wheat growth and yield in combination with an optimized nitrogen (N) fertilizer application scheme. This could lead to a significant reduction of N fertilizer application without affecting the subsequent grain yields. The screened products collection includes (1) Mix1 (a mix of Azospirillum sp., Azorhizobium sp., and Azoarcus sp.), (2) Mix2 (a mix of Mix1 complemented with two strains of phosphorus-solubilizing Bacillus sp.), (3) Bacillus amyloliquefaciens a, (4) B. subtilis, and (5) B. amyloliquefaciens b. These biostimulants were screened under greenhouse and field conditions in 2014 by using spring and winter wheat varieties respectively. There was a significant increase in root dry weight and in root per shoot ratio of plants inoculated with Mix1. Under field conditions, the interaction between PGPR inoculation and N fertilizer application was assessed. The grain yield was negatively impacted by low N fertilizer applications. Under such conditions, the inoculation of the wheat rhizosphere with Bacillus subtilis increased the grain yield by 15% relative to the water control. However, in the field trial, the variability between plot replicates was high and lead to non-significant results. Based on those results, modified screening strategies for PGPR selection were set up for the 2015 trials to reduce field variability and possibly achieve higher yield increases. [less ▲]

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See detailEmotion, violence, cohabitation. A propos de Vers la cohabitation de Judith Butler
Cormann, Grégory ULg

Conference (2015, November 16)

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See detailDeterminants of Access to Agricultural Credits for Small Scale Farmers in the Southern Province of Rwanda
Musabanganji, Edouard ULg; Antoine, Karangwa; Lebailly, Philippe ULg

in Book of Proceedings Sixth International Scientific Agricultural Symposium "AgroSym 2015" (2015, November 15)

This study investigated the determinants of financial inclusion for small scale farmers by focusing on the access to formal and informal agricultural credits in the Southern Province of Rwanda. Data were ... [more ▼]

This study investigated the determinants of financial inclusion for small scale farmers by focusing on the access to formal and informal agricultural credits in the Southern Province of Rwanda. Data were collected from 310 farmers from Huye and Nyamagabe districts through an open-ended structured questionnaire and analysed using the binary logistic regression method. The major findings, on one hand, showed that among the requested and approved agricultural loans, 87.2% and 12.7% were from informal and formal financial institutions respectively. Among those who accessed agricultural credits, 59.7% were from Huye and 40.3% from Nyamagabe. On the other hand, it was revealed that the household characteristics and the community attributes are the most important determinants. Those household characteristics include household income and expenditure, Ubudehe socio-economic category of the household, off-farm employment and the size of the land owned by the household whereas community attributes involve residence area, transport and informal financial services availability. Regarding farmer characteristics, the education level was found to be the only factor affecting the smallholder farmers' access to agricultural credit. In light of the findings, it was recommended to conduct sensitization sessions focusing on the importance of agricultural credits for smallholder farmers especially in the areas with high level of poverty. In addition, there is need to work on alleviating the formal agricultural credits access barriers, and to conduct a study on the dynamics of informal and formal agricultural credits up take and usage by smallholder farmers to explore all dimensions of financial inclusion in the study area. [less ▲]

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See detailThe Q-Codes. From Dunedin 2007 to Hyderabad 2015
Jamoulle, Marc ULg

Conference (2015, November 14)

Aim Coding abstracts of communications of GPs during congress allows more efficient exchange of information through a specific indexing process. Coding with Core Content Classification in General Practice ... [more ▼]

Aim Coding abstracts of communications of GPs during congress allows more efficient exchange of information through a specific indexing process. Coding with Core Content Classification in General Practice/Family Medicine (3CGP/FM), an association of ICPC and of a new tool called Q-Codes means identifying the main concepts the writer is willing to share in his/her contribution. This is called ‘text classification’ or ‘topic list building’ in computer sciences and ‘qualitative data analysis’ in cognitive sciences. The GP is dealing with issues concerning the patient and with issues concerning the management of the job. Symptoms, diagnosis and process are up to what we will call clinical activities. General management as well as ethical or quality related issues are up to what we will call non-clinical or managerial activities. Clinical activities will be identified in the abstracts by the use of the International Classification of Primary Care second edition, electronic, version 5 (ICPC-2 e ver5). Managerial activities will be identified in the abstracts by the use of the Q-Codes, version 2.1, 2015 which we are explaining now in detail. Method The European cross-lingual portal of health terminologies for indexing and searching Web resources (www.hetop.eu) is using the OWL 2 Web Ontology Language, relying for instance to Bioportal and connected to the world of the Internet of data. We have developed the terminological content of 183 items called Q-codes using a graphic Interface, filling the knowledge base with relevant information about the concept studied, linking them to professional terminologies like MeSH, or to lay ones like Babelnet and DBpedia, if any, and relying them to top bibliographic free full text citations of the domain. Results 183 Q-Codes have been designed and 177 extensive terminological records are available online, for now for beta testers. The whole process is described on http://docpatient.net/3CGP. The ongoing version of the Q-codes is available here in 6 languages http://docpatient.net/3CGP/Q-Codes_ver_2_2.pdf The poster present a general overview of the terminological development. [less ▲]

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See detailFungal skin infections: from the clinic to the laboratory
Hayette, Marie-Pierre ULg

Conference (2015, November 14)

Superficial fungal infections are largely represented in the world population and are mainly caused by dermatophytes. Clinical signs can be confusing and it is important to get a rapid diagnostic to apply ... [more ▼]

Superficial fungal infections are largely represented in the world population and are mainly caused by dermatophytes. Clinical signs can be confusing and it is important to get a rapid diagnostic to apply the right treatment.The diagnostic procedures are still culture-based methods but molecular technologies are recently available under commercial kits and will be probable part of a new algorithm in the laboratory diagnosis. [less ▲]

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See detailDer Wiederaufbau der deutsch-belgischen Beziehungen nach 1945
Brüll, Christoph ULg

Conference (2015, November 14)

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See detailStructure of the Q-Codes semantic knowledge base in General Practice/Family Medicine
Jamoulle, Marc ULg; Grosjean, Julien; Darmoni, Stefan

Poster (2015, November 13)

Aim ; Coding abstracts of communications of GPs during congress allows more efficient exchange of information through a specific indexing process. Coding with Core Content Classification in General ... [more ▼]

Aim ; Coding abstracts of communications of GPs during congress allows more efficient exchange of information through a specific indexing process. Coding with Core Content Classification in General Practice/Family Medicine (3CGP/FM), an association of ICPC and of a new tool called Q-Codes means identifying the main concepts the writer is willing to share in his/her contribution. This is called ‘text classification’ or ‘topic list building’ in computer science and ‘qualitative data analysis’ in cognitive science. The GP is dealing with issues concerning the patient and with issues concerning the management of the job. Symptoms, diagnosis and process are what we will call clinical activities. General management as well as ethical or quality related issues are up to what we will call non-clinical or managerial activities. Clinical activities will be identified in the abstracts by the use of the International Classification of Primary Care second edition, electronic, version 5 (ICPC-2 e ver5). Managerial activities will be identified in the abstracts by the use of the Q-Codes, version 2.1, 2015 which we are explaining now in detail. Method ; www.hetop.eu is the European cross-lingual portal of health terminologies for indexing and searching Web resources. The portal uses OWL 2 Web Ontology Language. We have developed the terminological content of 183 items called Q-codes using a graphic interface, populating the knowledge base with relevant information about the concepts studied. These concepts are linked to: (i) professional terminologies such as MeSH, (ii) lay terminologies such as Babelnet and DBpedia, and (iii) top bibliographic free full text citations of the domain GP/FM. Results ; One hundred and eighty-three Q-Codes have been designed and 177 extensive terminological records are available online for now for beta testers. The whole process is described on http://docpatient.net/3CGP. The ongoing version of the Q-codes is available here in 6 languages http://docpatient.net/3CGP/Q-Codes_ver_2_2.pdf This poster present a general overview of the terminological development, showing the relations of the Q-Codes QT3, Quality Assurance [less ▲]

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See detailSnow cover evolution and its impact on flooding in the Ourthe River catchment (southeast of Belgium) over the period 1958­-2014 using the MAR model
Wyard, Coraline ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

Conference (2015, November 13)

The Ourthe River (southeast of Belgium) is one of the main tributaries of the Meuse River with a catchment area of 3500 km². About 50 % of the floods which occur in the Ourthe River catchment are due to ... [more ▼]

The Ourthe River (southeast of Belgium) is one of the main tributaries of the Meuse River with a catchment area of 3500 km². About 50 % of the floods which occur in the Ourthe River catchment are due to rainfall events associated with the melting of the snow which covers the Ardennes in winter. In this study, hydroclimatic conditions favourable to flooding were reconstructed over the period 1958-2014 using the regional climate model MAR (« Modèle Atmosphérique Régional ») forced by the ERA-interim reanalysis and by the NCEP1 reanalysis. As validation, the MAR results were compared to weather station-based data. A trends analysis was then performed in order to study the evolution of conditions favourable to flooding in the Ourthe River catchment. When the MAR model is forced by the NCEP1 reanalysis, results show a significant decrease in hydroclimatic conditions favourable to flooding because of a decrease in snow accumulation as well as a decrease in the frequency of extreme precipitation events in winter. When MAR is forced by the ERA-interim reanalysis, non-significant trends are found, which could be explained by an underestimation of the precipitation amount computed by the ERA-40 reanalysis before 1979. Further studies are needed to explain the decreasing trends in snow accumulation and extreme precipitation events. Moreover, an hydrological model could also be forced by the MAR outputs in order to improve flood detection. [less ▲]

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See detailDe Freaks à Decasia, de l'image du monstre à l'image monstrueuse
Jousten, Lison ULg

Conference (2015, November 13)

L’intervention vise à élargir la question de la monstruosité dans le cadre du cinéma, souvent réduite à une étude de motif, en confrontant Freaks (Tod Browning, 1932) à Decasia (Bill Morrison, 2002). Si ... [more ▼]

L’intervention vise à élargir la question de la monstruosité dans le cadre du cinéma, souvent réduite à une étude de motif, en confrontant Freaks (Tod Browning, 1932) à Decasia (Bill Morrison, 2002). Si au premier abord, tout semble séparer le classique hollywoodien qui fit figurer des monstres véritables à l’écran du film expérimental de found footage créé sur base d’images corrompues, l’analyse croisée des deux œuvres révèle une visée commune. [less ▲]

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See detailL’entrée à l’école maternelle, le vécu des familles en situation de précarité
Pirard, Florence ULg; Morgante, Aurélie; Housen, Marie ULg

Conference (2015, November 13)

Notre communication a pour objectif de mieux comprendre le vécu des familles lors de l’entrée de leur(s) enfant(s) à l’école maternelle en Fédération Wallonie Bruxelles (FWB, Belgique), en particulier ... [more ▼]

Notre communication a pour objectif de mieux comprendre le vécu des familles lors de l’entrée de leur(s) enfant(s) à l’école maternelle en Fédération Wallonie Bruxelles (FWB, Belgique), en particulier celui des familles en situation de précarité. Elle pose la question de la transition et de l’entrée à l’école maternelle dans le parcours des enfants et de leur famille, question peu étudiée dans les recherches belges et internationales. Elle s'inscrit dans un contexte caractérisé par une entrée relativement précoce à l'école maternelle (2 ans et demi) et une fréquentation massive comparativement aux taux de participation enregistrés dans d’autres pays européens. Pour beaucoup d’enfants, cette entrée représente la première expérience de vie dans un cadre professionnel car en FWB, comme dans les autres pays où l’offre de services est divisée, seule une partie des jeunes enfants ont accès à une place en milieux d’accueil avant l’école maternelle (27,7 % de taux de couverture en milieux d’accueil à la fin de l’année 2010 pour les moins de 3 ans), les enfants des familles en situation de précarité étant les moins représentés. Dans ce contexte, les résultats de nos recherches fondés sur des entretiens à visée compréhensive menés avec des parents, essentiellement des mères montrent les difficultés à établir un dialogue à partir de l’expérience de vie des enfants dans l’institution éducative qui semble souvent peu visible et compréhensible malgré l'importance que les participants lui est accorde. Ils nous amènent à réinterroger les pratiques d’accueil et d’éducation dans une perspective de coéducation, la formation initiale des professionnelles et plus largement les conditions d’un développement professionnel continu [less ▲]

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See detailFourniture de pages web expliquant la médecine du travail aux médecins généralistes
Mairiaux, Philippe ULg; Mortelmans, Katrien

Conference (2015, November 13)

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See detailLa place de l’énergie dans la régionalisation de l’Europe
Sisu, Madalina ULg

Conference (2015, November 13)

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See detailThe Roll of Small Businesses in Traditional Handcraft in Rural Development: A Case-Study Of Hanoi Suburban Rattan Enterprises
Nguyen, Thi Thu Hien ULg; Lebailly, Philippe ULg; NGUYEN, Van Nghien

in International Conference on Emerging Challenges, Hanoi 12 november 2015 (2015, November 12)

Rural industrial development and new rural development programmes are the main target of Vietnam in the process of industrialization – modernization of the country. To expedite this process, it is ... [more ▼]

Rural industrial development and new rural development programmes are the main target of Vietnam in the process of industrialization – modernization of the country. To expedite this process, it is necessary to promote the development and encourage the contributions of small enterprise in general and small enterprise rural in particular because practices in many countries show the important role of small and micro enterprises in local development. This paper presents the initial results of research to understand the economic–social contributions of rural enterprises to local development through the mobilization of local resources as well as establishment of the economic-social relations in local of rattan’s enterprises in the suburb of Hanoi, and then propose some measures to facilitate the operation of enterprises and promote the contribution of rattan’s enterprises for local development. [less ▲]

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See detailFarms for Future? Contribution of agroecological farms to the delivery of ecosystem services
Boeraeve, Fanny ULg; Dendoncker, Nicolas; Dufrêne, Marc ULg et al

Conference (2015, November 12)

In the western part of the Hainaut province in Belgium, a dynamic network of several farms intentionally incorporates biodiversity within their practices and across multiple scales. While it is suggested ... [more ▼]

In the western part of the Hainaut province in Belgium, a dynamic network of several farms intentionally incorporates biodiversity within their practices and across multiple scales. While it is suggested that such diversification of agricultural practices supports ecological processes in turn favoring biomass production and providing other ecosystem services (ES) to society, few studies have actually attested this fact. A recent review by Kremen and Miles (2012) comparing the provision of 12 ES in organic and conventional systems concludes that ‘integrated whole-system studies of the influence of different farming practices on multiples ES are critically needed’; a conclusion confirmed by the few existing farm-scale ES assessments. This research’s goal is to fulfill this gap by providing comprehensive knowledge about the socio-ecological performance of such systems. To achieve this, we rely on the tool of integrated ES assessment, which includes both a biophysical and a social valuation. Such value-pluralism is of high relevance in agricultural contexts, where multiple values are required to capture the diversity of needs and wants that nature can contribute to fulfill for society and individuals. With the aim to get better insights into societal values, a ‘field thesis committee’ was launched. This latter one includes local farmers and citizens who are consulted throughout the research. For instance, at the start of the project, a participative ES selection was organized to guide the research towards ES important in the eyes of local stakeholders. The presentation first introduces the innovative multi-actor and multi-disciplinary approach developed in this project. Preliminary results are then presented and interpreted. We believe our approach can bring significant contribution to body of knowledge on the reconciliation of social and environmental expectancies. [less ▲]

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See detailFROM METABOLOMICS STUDY OF AGE RELATED MACULAR DEGENERATION (AMD) TO THE DEVELOPMENT OF NEW PDK INHIBITORS
Arslan, Deniz ULg; Schoumacher, Matthieu ULg; Pirotte, Bernard ULg et al

in Arslan, Deniz (Ed.) Gazi Pharma Symposium Abstract Book (2015, November 12)

Metabolomics is one of the most recent technologies in the Omics sciences defined as “the comprehensive characterization of small molecules (called metabolites) in different biological samples.” This ... [more ▼]

Metabolomics is one of the most recent technologies in the Omics sciences defined as “the comprehensive characterization of small molecules (called metabolites) in different biological samples.” This methodology can be applied in many areas, such as biomarker discovery, clinical studies, drug efficacy and toxicity evaluation, diagnostic tools, quality control or drug discovery. Its capability to extract biochemical information associated with a cellular or biological system makes this technique a powerful tool for Medicinal Chemistry. In this work, we present a 1H NMR metabolomics study applied to therapeutic target discovery. Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population of industrialized countries. This blindness results from the deterioration of the macula, a small part of the retina specialized for the high-acuity vision. Exudative AMD, called “wet”, is characterized by the formation of new blood vessels growing under the retina according to a process named choroidal neovascularization (CNV). Currently, the aetiology and pathogenesis of AMD remain unclear. Nevertheless, a recent metabolomics study performed on the serum of “wet” AMD patients and on a CNV murine model, that mimics the effect of “wet” AMD, have demonstrated that lactate level is clearly involved in the severity of the pathology as well as the relationship between lactate, CNV and AMD. According to this result, we suggest a new therapeutic approach of AMD based on the normalization of blood lactate level. The modulation of the lactate plasma concentration by treatment of the animals with synthetic compounds and more specifically Pyruvate Dehydrogenase Kinase (PDK) inhibitors significantly decrease the CNV. Starting from these results, development of new PDK inhibitors could open the way to innovative treatment opportunities in AMD disease. [less ▲]

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See detailAre diagrams dispensable in proofs ?
Leclercq, Bruno ULg

Conference (2015, November 11)

Detailed reference viewed: 20 (1 ULg)