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See detailOPTIMIZATION OF A FULLY AUTOMATED ELECTROPHORETICALLY MEDIATED MICROANALYSIS SYSTEM FOR CYP1A1 ACTIVITY MONITORING
Farcas, Elena ULg; Servais, Anne-Catherine ULg; Lamalle, Caroline et al

Conference (2016, October 01)

Objective of the study Since CYP1A1, a member of cytochrome P450 superfamily, has been described to be over expressed in various types of cancer, our study was focused on the optimization of a fully ... [more ▼]

Objective of the study Since CYP1A1, a member of cytochrome P450 superfamily, has been described to be over expressed in various types of cancer, our study was focused on the optimization of a fully automated system for the monitoring of this particularly interesting enzyme. Moreover, the potentiality of this approach to screen CYP1A1 inhibitors was investigated. Materials and methods The experiments were carried out on a HP3DCE system using an on-column DAD. The EMMA procedure was performed by injecting a plug containing the co-factor(NADPH) and the substrate(7-ethoxycoumarin) between two plugs of CYP1A1 supersomes. The reaction was triggered by the application of a voltage switch. The voltage was then turned off to allow the metabolic reaction to occur. The separation of the components was then performed. Results Satisfying results were obtained using CYP1A1 at a concentration of 200 pmol/mL, while the incubation time was settled to 15 min. A DoE was performed to find the best mixing conditions. The amount of metabolite obtained was comparable to the one detected after conventional off-line metabolization. The ability of our system to monitor CYP1A1 inhibition was then proven with apigenin, a well-known CYP1A1 inhibitor. Conclusions The present study describes the development of a fully automatized in-capillary method for CYP1A1 activity monitoring and proves the potentialy of our system to be used for the screening of CYP1A1 inhibitors. The advantages of performing inline metabolization assays are mainly the miniaturization and the automatization of the process. Besides, the reagents consumption is drastically reduced due to the injection of few tens of nanoliters. [less ▲]

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See detailThyroid nodule : metastasis or primary neoplasm ?
PETIGNOT, Sandrine ULg; PETROSSIANS, Patrick ULg; VAN DAELE, Daniel ULg et al

in 26nd meeting of the Belgian Endocrine Society - Abstract book (2016, October)

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See detailQuality Control Laboratories involved in the WHO Prequalification
Marini Djang'Eing'A, Roland ULg

Conference (2016, October)

Detailed reference viewed: 24 (2 ULg)
See detailJuno Ultraviolet Spectrograph (Juno-UVS) Observations of Jupiter during Approach
Gladstone, G. Randall; Versteeg, Maarten; Greathouse, Thomas K. et al

Conference (2016, October)

We present the initial results from Juno Ultraviolet Spectrograph (Juno-UVS) observations of Jupiter obtained during approach in June 2016. Juno-UVS is an imaging spectrograph with a bandpass of 70<λ<205 ... [more ▼]

We present the initial results from Juno Ultraviolet Spectrograph (Juno-UVS) observations of Jupiter obtained during approach in June 2016. Juno-UVS is an imaging spectrograph with a bandpass of 70<λ<205 nm. This wavelength range includes all important ultraviolet (UV) emissions from the H<SUB>2</SUB> bands and the H Lyman series which are produced in Jupiter's auroras, and also the absorption signatures of aurorally-produced hydrocarbons. The Juno-UVS instrument telescope has a 4 x 4 cm<SUP>2</SUP> input aperture and uses an off-axis parabolic primary mirror. A flat scan mirror situated near the entrance of the telescope is used to observe at up to ±30° perpendicular to the Juno spin plane. The light is focused onto the spectrograph entrance slit, which has a "dog-bone" shape 7.2° long, in three sections of 0.2°, 0.025°, and 0.2° width (as projected onto the sky). Light entering the slit is dispersed by a toroidal grating which focuses UV light onto a curved microchannel plate (MCP) cross delay line (XDL) detector with a solar blind UV-sensitive CsI photocathode. Tantalum surrounds the spectrograph assembly to shield the detector and its electronics from high-energy electrons. All other electronics are located in Juno's spacecraft vault, including redundant low-voltage and high-voltage power supplies, command and data handling electronics, heater/actuator electronics, scan mirror electronics, and event processing electronics. The purpose of Juno-UVS is to remotely sense Jupiter's auroral morphology and brightness to provide context for in situ measurements by Juno's particle instruments. Prior to Jupiter Orbit Insertion (JOI) on July 5, Juno approach observations provide a rare opportunity to correlate local solar wind conditions with Jovian auroral emissions. Some of Jupiter's auroral emissions (e.g., polar emissions) may be controlled or at least affected by the solar wind. Here we compare synoptic Juno-UVS observations of Jupiter's auroral emissions (~40 minutes per hour, acquired during 2016 June 3-30) with in situ solar wind observations, as well as related Jupiter observations obtained from Earth. [less ▲]

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See detailUnexpected high levels of Cobalamin (Vitamin B12): Numerous interferences are decreased by PEG treatment.
LADANG, Aurélie ULg; VRANKEN, Laura ULg; CAVALIER, Etienne ULg

Poster (2016, October)

Cobalamin (Vitamin B12) deficiency is a common cause of anemia. High levels of serum cobalamin is mainly due to cobalamin supplementation. It has also been associated with hematological malignancies ... [more ▼]

Cobalamin (Vitamin B12) deficiency is a common cause of anemia. High levels of serum cobalamin is mainly due to cobalamin supplementation. It has also been associated with hematological malignancies, liver or renal diseases. Cobalamin is sometimes found elevated in autoimmune disorders and infectious diseases but concerns are raised on the fact that those serum increases might be due to interference with immunoassays. Those data’s shed the lights on the high prevalence of interference in patients with unexpected high cobalamin level. Precipitation with PEG appears to be an easy and costless method to increase the reliability of cobalamin dosage. In accordance with our results, we recommand to treat systematically every serum with a cobalamin >1500 ng/L. [less ▲]

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See detailFrom guidelines to real daily practice : prolactinoma in pregnancy
VROONEN, Laurent ULg; Potorac, Iulia ULg; D'Andréa, S et al

in Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie (2016, October)

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See detailComportement clinique des couronnes monolithiques en zircone
KOENIG, Vinciane ULg; Wulfman, Claudine; MAINJOT, Amélie ULg

in Les entretiens d'Odontologie-Stomatologie 2016 (2016, October)

Les études cliniques sur les couronnes et les bridges en zircone Y-TZP ont indiqué des taux d'échecs élevés liés aux fractures cohésives de la céramique d’émaillage (chipping). Pour remédier à ce problème ... [more ▼]

Les études cliniques sur les couronnes et les bridges en zircone Y-TZP ont indiqué des taux d'échecs élevés liés aux fractures cohésives de la céramique d’émaillage (chipping). Pour remédier à ce problème, les fabricants commercialisent des couronnes monolithiques, entièrement en zircone, qui sont simplement maquillées en surface. Cependant, ces restaurations sont suspectées d’être plus sensibles à la fatigue hydrique de la zircone, problème qui aboutit à une baisse des propriétés mécaniques et qui fut à l’origine de nombreux échecs avec les prothèses de hanche. En effet, l’absence de céramique d’émaillage sur les couronnes monolithiques les rend plus vulnérables vis à vis du milieu oral ; de plus, certaines zircones de haute translucidité, spécifiquement développées pour cette indication, sont réputées plus sensibles en raison d’une plus grande métastabilité. Enfin, le recul clinique sur ces restaurations est très faible et leur comportement général, notamment en terme d’usure des dents antagonistes, a besoin d’être étudié. Une étude clinique est actuellement menée à l’Université de Liège, en collaboration avec l’Université Paris Descartes, afin d’évaluer le comportement clinique de la zircone non émaillée en milieu buccal, et particulièrement la fatigue hydrique, sur une période de 5 ans. Les résultats à très court terme (6 mois) mettent en évidence le bon comportement clinique des restaurations monolithiques en zircone, avec cependant une usure rapide de la glaçure, ce qui pourrait promouvoir la fatigue hydrique. Les zones de transformation cristalline détectées soulignent la nécessité d’une cuisson de régénération de la zircone suite aux ajustements occlusaux par fraisage. [less ▲]

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See detailBreaking Bad News: the TAKE five program.
GILLET, Aline ULg; VAN CAUWENBERGE, Isabelle ULg; TUBES, Rebecca ULg et al

Poster (2016, October)

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See detailMaladie de Cushing et kyste de la poche de Rathke : un défi diagnostique
VROONEN, Laurent ULg; KREUTZ, Julie ULg; Potorac, Iulia ULg et al

in Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie (2016, October)

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See detailLes corps des scientifiques et de l’intellectuel dans la revue La Recherche
Dondero, Maria Giulia ULg

in Mabrour, Abdel; Bajomée, Danielle (Eds.) La lettre et l’image. Enquêtes interculturelles sur les territoires du visible (2016, October)

Ce travail entend examiner les rapports entre les représentations photographiques des corps des scientifiques dans la revue de vulgarisation savante La Recherche, tels les portraits, les scènes de travail ... [more ▼]

Ce travail entend examiner les rapports entre les représentations photographiques des corps des scientifiques dans la revue de vulgarisation savante La Recherche, tels les portraits, les scènes de travail collectif en laboratoire etc., et les conceptions de la science qui en sont valorisées. L’étude des relations entre les photographies et les textes qui les accompagnent ont ainsi pour objectif de déployer une réflexion non seulement sur les différents types de commensurabilité entre le langage verbal et le langage visuel mais aussi sur le fait que le langage visuel est à même de forger de manière tout à fait autonome des valeurs identitaires et des formes de vie identifiables via l’analyse sémiotique. Notre exploration se développera en deux volets : le premier vise à esquisser la méthodologie de la sémiotique visuelle pour pouvoir introduire les niveaux pertinents de l’analyse sémiotique, le deuxième consiste à analyser un corpus constitué de textes tirés de quelques numéros de la revue La Recherche en en distinguant les différents genres discursifs (entretien, présentation de travaux en cours, etc.) et les différents types de cadrage et de mise en scène photographique afin d’expliquer comment ils se combinent avec les prises de position épistémologiques valorisées. [less ▲]

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See detailLe syndrome de De Morsier : une cause congénitale méconnue d'hypopituitarisme
VALDES SOCIN, Hernan Gonzalo ULg; VERLOES, Alain ULg; Debray, François-Guillaume ULg et al

in Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie (2016, October)

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See detailUtilisation de la cabergoline dans le traitement palliatif de la maladie de Cushing : l'étude Frenchcab
Ferriere, A; Cortet, C; Chanson, P et al

in Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie (2016, October)

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See detailUn chantier de modernisation des contextes de travail: le "New Way of Working" dans une compagnie d'assurances
Jemine, Grégory ULg

Conference (2016, October)

Dans les réflexions récentes portant sur l’organisation du travail en entreprise, nombreux sont les auteurs qui s’intéressent à la question des « nouvelles formes d’organisation ». Sous cette appellation ... [more ▼]

Dans les réflexions récentes portant sur l’organisation du travail en entreprise, nombreux sont les auteurs qui s’intéressent à la question des « nouvelles formes d’organisation ». Sous cette appellation se rassemblent des courants aux dénominations différentes (entreprise libérée, entreprise virtuelle, « holacracie »…) partageant cependant des principes fondateurs communs (tels que la flexibilité, l’autonomie du collaborateur ou encore la digitalisation des pratiques de travail). A travers une étude de trois mois au sein d’un département de protection juridique d’une importante compagnie d’assurances située à Bruxelles, nous étudions un projet de changement basé sur le « New Way of Working » (NWoW) – un chantier managérial se développant principalement aux Pays-Bas et en Belgique depuis une dizaine d’années, proposant une « nouvelle » vision des travailleurs dans le secteur tertiaire. Nous rendons compte des trois composantes clés du projet NWoW telles qu'il est problématisé dans notre étude de cas: les Bricks (travail en open-space, bureaux flexibles, travail à distance), les Bytes (nouveaux outils numériques, travail sans papier, connectivité) et les Behaviors (autonomie et responsabilité des collaborateurs, passage du contrôle à la confiance). Nous concluons par une réflexion structurée autour des "4C": dans ces nouveaux environnements de travail, de nouvelles questions émergent en termes de confiance, de contrôle, de cohésion et de coordination. [less ▲]

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See detailHypogonadism due to a novel inactivating mutation of the luteinizing hormone beta subunit (LHB) gene leading to impaired protein trafficking
Potorac, Iulia ULg; Rivero-muller, a; Trehan, A et al

in 26nd meeting of the Belgian Endocrine Society - Abstract book (2016, October)

Detailed reference viewed: 20 (2 ULg)
See detailCassini UVIS Auroral Observations in 2016
Pryor, Wayne R.; Jouchoux, Alain; Esposito, Larry et al

Conference (2016, October)

In June of 2016, the Cassini Saturn orbiter began a series of high inclination orbits that will continue until September 2017 when the mission ends as Cassini enters the Saturn atmosphere. These orbits ... [more ▼]

In June of 2016, the Cassini Saturn orbiter began a series of high inclination orbits that will continue until September 2017 when the mission ends as Cassini enters the Saturn atmosphere. These orbits present excellent views of Saturn's polar regions suitable for auroral imaging at the closest distances to date, with the additional prospect of simultaneous particle and fields measurements within the sources of Saturn Kilometric Radiation (SKR) associated with ultraviolet auroral emissions and/or acceleration regions likely coinciding with them. We will present new Cassini Ultraviolet Imaging Spectrograph (UVIS) auroral images, spectra and movies obtained during the summer and fall of 2016 and put them in the context of auroral data collected since Cassini orbit insertion in 2004. Included in the new data will be UVIS south polar observations obtained simultaneously with Hubble Space Telescope observations of the north polar region on June 29, 2016 and August 19, 2016. [less ▲]

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See detailLes dernières évolutions en droit européen en matière d'assurance protection juridique
Wildemeersch, Jonathan ULg

in Wildemeersch, Jonathan (Ed.) L'assurance protection juridique : quid pour demain? (2016, October)

L'assurance protection juridique est régie par une directive européenne. Comment la Cour de justice interprète-t-elle le principe du libre choix de l'avocat imposé par la directive ? Tel est l'objet de ... [more ▼]

L'assurance protection juridique est régie par une directive européenne. Comment la Cour de justice interprète-t-elle le principe du libre choix de l'avocat imposé par la directive ? Tel est l'objet de cette contribution. [less ▲]

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See detailA membrane-type- matrix metalloproteinase (MT1-MMP) - discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells
Assent, Delphine; Bourgot, Isabelle ULg; Hennuy, Benoit et al

Poster (2016, October)

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and proapoptotic properties. To ... [more ▼]

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and proapoptotic properties. To develop metastatic capabilities, tumour cells must acquire the capacity to cope with this novel microenvironment. How cells interact with and respond to their microenvironment during cancer dissemination remains poorly understood. To address the impact of type I collagen on the fate of tumour cells, human breast carcinoma MCF-7 cells were cultured within three-dimensional type I collagen gels (3D COL1). Using this experimental model, we demonstrate that membrane type-1 matrix metalloproteinase (MT1-MMP), a proteinase overexpressed in many aggressive tumours, promotes tumour progression by circumventing the collagen-induced up-regulation of BIK, a pro-apoptotic tumour suppressor, and hence apoptosis. A transcriptomic analysis was performed to decipher the molecular mechanisms regulating 3D COL1-induced apoptosis in human breast cancer cells. Control and MT1-MMP expressing MCF-7 cells were cultured on two-dimensional plastic plates or within 3D COL1 and a global transcriptional time-course analysis was performed. Shifting the cells from plastic plates to 3D COL1 activated a complex reprogramming of genes implicated in various biological processes. Bioinformatic analysis revealed a 3D COL1-mediated alteration of key cellular functions including apoptosis, cell proliferation, RNA processing and cytoskeleton remodelling. By using a panel of pharmacological inhibitors, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase specifically activated by collagen, as the initiator of 3D COL1-induced apoptosis. Our data support the concept that MT1-MMP contributes to the inactivation of the DDR1-BIK signalling axis through the cleavage of collagen fibres and/or the alteration of DDR1 receptor signalling unit, without triggering drastic alterations of the transcriptome of MCF-7 cells. [less ▲]

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See detailClassification criteria for neurogenic claudication caused by lumbar spinal stenosis
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in 9th Interdisciplinary World Congress on Low Back And Pelvic Girdle Pain (2016, October)

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis ... [more ▼]

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis (LSS) or lumbar disc herniations (LDH) may not be associated with symptoms, clinical classification criteria based upon patient symptoms and physical examination findings are required. This study sought to develop a set of criteria identifying patients with neurogenic claudication (NC) caused by LSS and patient with radicular pain (RP) caused by LDH. This abstract reports the results concerning NC caused by LSS. METHODS Phase 1: Nineteen spine specialists (clinicians and researchers) from 8 countries participated in a Delphi process, using an internet program, to rank symptoms and signs which suggest LSS as the cause of NC or DH as the cause of RP. Phase 2: Nineteen different spine specialists (surgeons and non-surgeons) from 5 countries recruited patients during office visits and classify them with a high degree of confidence as having with either: 1) NC caused by LSS 2) RP caused by LDH or 3) non-specific low back pain (NSLBP) with non-specific leg pain radiation. Patients completed survey items and specialists documented examination signs. Signs and symptoms present in ≥ 10 patients were analyzed by using Generalized Estimating Equations (GEE). Patients with NC caused by LSS or NSLBP served as controls. Items with p<0.1 in univariate analysis were entered in the multivariate analysis. A score to predict NC caused by LSS was developed based on the coefficient of the GEE, and used to obtain a ROC curve and the associated area under the curve (AUC). RESULTS A list of 46 clinical signs and 28 patient-reported symptoms were selected by the group of spine specialists during the 1st phase. For the 2nd phase, 209 patients with high confidence in the diagnosis were included 63 NC caused by LSS, 89 RP caused by DH, and 57 NSLBP with non-specific leg pain radiation. Items which predicted NC with a p-value <0.1 included age >60, bilateral leg pain, leg pain relieved by sitting, leg pain decreased by leaning or flexing, positive30 seconds extension test, negative straight leg raise test. The score had an AUC of 0.91, and the cutoff to obtain a specificity of 92.1% resulted in a sensitivity of 80.0%. CONCLUSION An international collaboration of surgeon and non-surgeon spine specialists produced a set of diagnostic criteria with high specificity and sensitivity for identifying patients with NC caused by LSS. Using this set could improve the quality of basic science and clinical research in this field by improving homogeneity within groups of patients. [less ▲]

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See detailIT Manager Crisis Leadership: Do Prescriptions Given for General Management Apply?
Tapanainen, Tommi ULg; Hosoya, Ryuichi; Kamioka, Taro et al

Conference (2016, October)

Earthquakes are destructive events, but can also give opportunities for learning in crisis management for organizational information technology (IT) functions. In their role as stewards of company data ... [more ▼]

Earthquakes are destructive events, but can also give opportunities for learning in crisis management for organizational information technology (IT) functions. In their role as stewards of company data and IT, it is important that IT managers participate in company crisis management activities. However, the role of IT managers in crisis management is not well understood. This paper addresses IT manager actions during the crisis response effort, when appropriate actions need to be taken at short notice. Recognizing that few guidelines exist for IT manager leadership in these situations, we attempt to fit leadership recommendations intended for the general management to five cases of IT manager crisis response activity during earthquakes. We find that several recommendations from this set were relevant also for IT managers, showing that IT managers can learn from crisis response lessons derived from the general management. [less ▲]

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See detailWavelet series representations for pathwise Young integrals
Esser, Céline ULg

Conference (2016, October)

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See detailLa médiation interculturelle en milieu hospitalier
Cornet, Annie ULg; Coulée, Camille

Conference (2016, October)

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See detailCation-doped Cu2O as a transparent p-type semiconducting oxide with enhanced performances: A comparison between strontium and magnesium incorporation
Avelas Resende, João ULg; Brochen, Stéphane; Bergerot, Laurent et al

Conference (2016, October)

In the group of semiconducting metallic oxides, cuprous oxide (Cu2O) presents promising electrical and manufacturing features for a variety of applications as p-type transparent material suitable in the ... [more ▼]

In the group of semiconducting metallic oxides, cuprous oxide (Cu2O) presents promising electrical and manufacturing features for a variety of applications as p-type transparent material suitable in the domains of transparent electronics and photovoltaic cells. However Cu2O suffers from optical and electrical limitations, due to a relatively small bandgap of 2.17 eV and a fairly high resistivity (> 102 Ω.cm) in intrinsic thin films at room temperature. In this work, we successfully doped Cu2O thin films with different divalent cations, namely Sr and Mg, by metal-organic chemical vapour deposition. We compared the effects of each element on crystallographic structure, films morphology, electronic transport and optical transmittance. In both cases, the presence of the cation contributed to a higher stability of the Cu2O phase, reducing the appearance of CuO parasitic phase. Nevertheless, a SrCO3 phase was detected in the Sr doped system. In terms of electrical properties, the incorporation of Sr, up to 16%, reduced the resistivity down to 1Ω.cm, with a mobility of 16 cm2.V-1.s-1. Moreover, the incorporation of strontium also leads to the emergence of a with a deep acceptor level located around EA = 278 ± 21 meV above the top of the valence band. The concentration of this deep acceptor level, attributed to simple copper vacancies, drastically increases with the strontium content, due to a decrease of its formation energy. The effect on optical transmittance could not be detected. The Mg-doped Cu2O thin films were monophasic and showed a higher resistivity of 6.6 Ω.cm at an Mg concentration of 17%, due to the lower mobility, 1 cm2.V-1.s-1. Although, the presence of this dopant contributes for the highest charge-carrier density observed in this work, up to 8x1017 cm-3. As in the Sr case, this can be explained by a simple copper vacancy doping mechanism assisted by cation incorporation. Additionally, a slight increase of transparency is observed when compared to intrinsic Cu2O. The control of carrier concentration and mobility values by dopant concentration, as well as the improvements in phase stability and transparency are key factors for the application of this versatile p-type oxide in transparent electronics and solar cells applications. [less ▲]

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See detailStudy of the SV2A protein role in Epilepsy.
Bartholomé, Odile ULg; Van Den Ackerveken, Priscilla ULg; Wislet, Sabine ULg et al

Poster (2016, October)

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See detailHematological and Biochemical variations amoug Belgian blue cattle and dairy cows in Belgium
Ramery, Eve ULg; Guyot, Hugues ULg

in Siliart, Brigitte; Jaillardon, Laetitia (Eds.) Proceedings of the 18th ESVCP (2016, October)

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See detailRobust discriminant analysis based on the joint graphcial lasso estimator
Aerts, Stéphanie ULg; Croux, Christophe; Wilms, Ines

Poster (2016, October)

Linear and Quadratic Discriminant Analysis (LDA/QDA) are the most often applied classification rules under the normality assumption. When there is not enough data, the quadratic rule, which requires the ... [more ▼]

Linear and Quadratic Discriminant Analysis (LDA/QDA) are the most often applied classification rules under the normality assumption. When there is not enough data, the quadratic rule, which requires the estimation of one precision matrix in each class, is often replaced by the linear one, based on the homoscedasticity assumption. This strong assumption is however rarely verified in practice and ignores the intrinsic différences between groups that may be of particular interest in the classification context. In this aper, alternatives to the usual maximum likelihood estimates for the precision matrices are proposed that borrow strength across classes while allowing for heterogeneity at the same time. This results in a classifier that is intermediate between QDA and LDA. Moreover, our estimator is sparse: the undesirable effect of uninformative variables is reduced. The performance of the method is illustrated through simulated and real dataset examples. [less ▲]

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See detailSomatic mosaicism is implicated in the etiology of XLAG syndrome
Rostomyan, Liliya ULg; Daly, Adrian ULg; Yuan, Bo et al

in 26nd meeting of the Belgian Endocrine Society - Abstract book (2016, October)

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See detailA new clinical presentation of a non-so-rare disease, the Di George syndrome
VROONEN, Laurent ULg; D'Andrea, S; Tome, M et al

in Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie (2016, October)

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See detailClassification Criteria for Neurogenic Claudication Caused by Lumbar Spinal Stenosis
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in EuroSpine 2016 (2016, October)

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis ... [more ▼]

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis (LSS) or lumbar disc herniations (LDH) may not be associated with symptoms, clinical classification criteria based upon patient symptoms and physical examination findings are required. This study sought to develop a set of criteria identifying patients with neurogenic claudication (NC) caused by LSS and patient with radicular pain (RP) caused by LDH. This abstract reports the results concerning NC caused by LSS. METHODS Phase 1: Nineteen spine specialists (clinicians and researchers) from 8 countries participated in a Delphi process, using an internet program, to rank symptoms and signs which suggest LSS as the cause of NC or DH as the cause of RP. Phase 2: Nineteen different spine specialists (surgeons and non-surgeons) from 5 countries recruited patients during office visits and classify them with a high degree of confidence as having with either: 1) NC caused by LSS 2) RP caused by LDH or 3) non-specific low back pain (NSLBP) with non-specific leg pain radiation. Patients completed survey items and specialists documented examination signs. Signs and symptoms present in ≥ 10 patients were analyzed by using Generalized Estimating Equations (GEE). Patients with NC caused by LSS or NSLBP served as controls. Items with p<0.1 in univariate analysis were entered in the multivariate analysis. A score to predict NC caused by LSS was developed based on the coefficient of the GEE, and used to obtain a ROC curve and the associated area under the curve (AUC). RESULTS A list of 46 clinical signs and 28 patient-reported symptoms were selected by the group of spine specialists during the 1st phase. For the 2nd phase, 209 patients with high confidence in the diagnosis were included 63 NC caused by LSS, 89 RP caused by DH, and 57 NSLBP with non-specific leg pain radiation. Items which predicted NC with a p-value <0.1 included age >60, bilateral leg pain, leg pain relieved by sitting, leg pain decreased by leaning or flexing, positive30 seconds extension test, negative straight leg raise test. The score had an AUC of 0.91, and the cutoff to obtain a specificity of 92.1% resulted in a sensitivity of 80.0%. CONCLUSION An international collaboration of surgeon and non-surgeon spine specialists produced a set of diagnostic criteria with high specificity and sensitivity for identifying patients with NC caused by LSS. Using this set could improve the quality of basic science and clinical research in this field by improving homogeneity within groups of patients. [less ▲]

Detailed reference viewed: 95 (2 ULg)
See detailSmall-angle scattering analysis of empty or loaded hierarchical porous materials
Gommes, Cédric ULg

Conference (2016, October)

Small-angle scattering (SAXS or SANS) is one of the few experimental methods available for the nanometer-scale study of physicochemical phenomena inside porous solids. Its potential, however, is often ... [more ▼]

Small-angle scattering (SAXS or SANS) is one of the few experimental methods available for the nanometer-scale study of physicochemical phenomena inside porous solids. Its potential, however, is often limited by the lack data analysis methods to convert scattering data into real-space structural information. This is notably the case for most porous materials of practical interest, which exhibit a hierarchical structure with micro, meso, and macropores, with often a secondary material confined in the pores, such as in supported catalysts, as well as fuel-cell and battery materials. Here, we discuss a general SAXS data analysis methodology for this type of material. Assuming that each structural level is statistically independent from the others and has a distinct characteristic length scale, compact mathematical expressions are derived for the scattering of the entire hierarchical structure [J.Phys.Chem.C, in press]. The method is illustrated with the SAXS analysis of SBA-15 micro- and meso-porous silica loaded with copper nitrate, as well as to supported catalysts obtained after calcining that material. The SAXS analysis shows that the nitrate permeates both the micro and mesopores, while the metallic copper obtained after calcination is found only in the mesopores. Moreover, the spatial distribution of the metal depends on the specifics of the calcination, as confirmed by electron tomography [Angew.Chem. 54 (2015) 11804]. The general methodology will be of interest to anyone interested in the quantitative analysis of small-angle scattering data from empty or loaded porous solids, and from any type of hierarchical material. [less ▲]

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See detailADAM28 - Generation of a conditional ADAM28 knock-out mouse Implication of ADAM28 in metastasis dissemination
Gérard, Catherine ULg; Rocks, Natacha ULg; Carnet, Oriane ULg et al

Poster (2016, October)

Introduction: ADAMs (a disintegrin and metalloproteinase) and ADAMTS proteinases (a disintegrin and metalloproteinase with thrombospondin motifs) are MMP (matrix metalloproteinase) -related enzymes ... [more ▼]

Introduction: ADAMs (a disintegrin and metalloproteinase) and ADAMTS proteinases (a disintegrin and metalloproteinase with thrombospondin motifs) are MMP (matrix metalloproteinase) -related enzymes, bearing a multi-domain structure. ADAM28 is a multipotent membrane-bound proteinase and its expression in tissues derived from the foregut in embryonic tissues suggests its involvement in the organogenesis of the respiratory tract. Moreover, ADAM28 is highly overexpressed in non-small-cell lung cancer samples. Notably through a global proteomic approach, we recently identified an upregulation of ADAM28 after induction of lung inflammation in a mouse model of asthma. In addition to data published in the literature and to our findings about ADAM28 expression in various pathological tissues, intrinsic characteristics of this proteinase argue for considering it as a potential regulator of cellular signalling pathways leading to an inflammatory pulmonary microenvironment and, eventually, to carcinogenesis. Indeed, ADAM28 bears an active catalytic domain and interacts in a non-proteolytic manner with some integrins (α4β1) and some P-selectin ligands involved in inflammatory cell migration. ADAM28 was also reported to display the capacity to cleave key mediators such as Von Willebrand factor, IGFBP3 (Insulin-like growth factor-binding protein 3) and CTGF (Connective Tissue Growth Factor). Very recently, ADAM28 was shown to shed pro-TNF-alpha suggesting an important role in tumour control. The present project aims at characterizing molecular mechanisms leading to tumour development in lungs. In the first part of this work, we intend to characterize the effects of ADAM28 depletion on physiological and pathological processes such as tumor development and metastatic dissemination in ADAM28 conditional knock-out mice. Methods: To understand the implication of ADAM28 in lung tumour development we instillated lungs of mice displaying a full knock-out genotype for ADAM28 with Lewis Lung Carcinoma cells and B16K1 melanoma cells. ADAM28 KO mice were also injected intravenously and a subcutaneously with these tumour cells. Results: There is no spontaneous phenotype for ADAM28 full knock-out animals. Preliminary results show an impaired lung tumors engrafment in ADAM28 wild type animals when compared to heterozygous or knock out littermates. Conclusion: This unique mouse strain provides a very precious tool to further investigate ADAM28 implication in various disease models including tumour growth and dissemination. The role of ADAM28 as a pro-tumor factor is widely described in the literature whereas our results suggest that ADAM28 has an anti-tumor function. [less ▲]

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See detailLe droit public et le tiers. Rapport belge
Bouhon, Frédéric ULg

in Les tiers. Journées panaméennes (2016, October)

Le présent rapport envisage le rôle du tiers en droit public belge, en se focalisant sur les trois thématiques retenues par le rapporteur général : le tiers et la norme (I), l’intérêt du tiers (II) et ... [more ▼]

Le présent rapport envisage le rôle du tiers en droit public belge, en se focalisant sur les trois thématiques retenues par le rapporteur général : le tiers et la norme (I), l’intérêt du tiers (II) et l’exécution de tâches publiques et le tiers (III). [less ▲]

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See detailThe peroxisome proliferator-activated receptor Alpha (PPARA) is expressed in non-somatotroph pituitary adenomas : a potential therapeutic target ?
Rotondi, S; Polidoro, MA; Morace, R et al

Poster (2016, October)

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See detailUV emissions of Jupiter: exploration of the high-latitude regions through the UV spectrograph on NASA's Juno mission
Hue, Vincent; Gladstone, G. Randall; Versteeg, Maarten et al

Conference (2016, October)

The Juno mission offers the opportunity to study Jupiter, from its inner structure to its magnetospheric environment. Juno was launched on August 2011 and its Jupiter orbit insertion (JOI) planned for ... [more ▼]

The Juno mission offers the opportunity to study Jupiter, from its inner structure to its magnetospheric environment. Juno was launched on August 2011 and its Jupiter orbit insertion (JOI) planned for July 4th 2016, will place Juno in a 53.5 days capture orbit. A period reduction maneuver will be performed two orbits later to place Juno into 14-days elliptical orbits for the duration of the nominal mission, which includes 36 orbits. Juno-UVS is a UV spectrograph with a bandpass of 70 ≤ λ ≤ 205 nm, designed to characterize Jupiter UV emissions. One of the main additions of UVS compared to its predecessors is a 2.54 mm tantalum shielding, to protect it from the harsh radiation environment at Jupiter, and a scan mirror, to allow for targeting specific auroral regions during perijove passes. The scan mirror is located at the front end of the instrument and will be used to look at +/- 30° perpendicular to the Juno spin plane. The entrance slit of UVS has a dog-bone shape composed by three sections with field of views of 0.2°x2.5°, 0.025°x2.0° and 0.2°x2.5°, as projected onto the sky. It will provide new constraints on Jupiter’s auroral nightside morphology and spectral features as well as the vertical structure of these emissions. It will bring remote-sensing constraints for the onboard waves and particle instruments (JADE, JEDI, Waves and MAG). The ability to change the pointing will allow relating the observed UV brightness of the regions magnetically connected to where Juno flies with the particles and waves measurements. We will discuss the planned observations and scientific targets for the nominal mission orbital sequence, which will consist of three UV datasets per orbit. We will present the results from the first orbit. As Juno orbit evolves during the mission, we will also present how these objectives evolve over time. [less ▲]

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See detailHypogonadisme hypogonadotrope anosmique associé à une nouvelle mutation hétérozygote c.937C>T, p.His314Tyr de l'isoforme IIIb du gène FGR1.
VALDES SOCIN, Hernan Gonzalo ULg; CORMAN, Vinciane ULg; LIBIOULLE, Cécile ULg et al

in Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie (2016, October)

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See detailA review of Silurian dispersed spore assemblages from the Arabian Plate: biostratigraphy and palaeogeography
Wellman, CH; Steemans, Philippe ULg; Breuer, P et al

Conference (2016, October)

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See detailHistorical Mortars in Wallonia (Belgium): A New Archaeological Approach. The Case of the Mediaeval Fortress of Pont-de-Bonne (Belgium, Province of Liège)
Demelenne, Marie; Bossiroy, Dominique; Dagrain, Fabrice et al

in Papayianni, Ioanna; Stefanidou, Maria; Pachta, Vasiliki (Eds.) 4th Historic Mortars Conference HMC2016 (2016, October)

This paper deals with an innovative methodology dedicated to the study of historical mortars. Gathering macroscopic observation, petrography in thin sections, chemical analyses as well as physical and ... [more ▼]

This paper deals with an innovative methodology dedicated to the study of historical mortars. Gathering macroscopic observation, petrography in thin sections, chemical analyses as well as physical and mechanical data namely obtained with non destructive technologies developed for the petroleum industry, it allows cross-interpretation that can effectively contribute to archaeological research through correlations with the age, the function, the technology and the provenance of each mortar sample collected on a studied site. Following a synthetic description of the proposed approach, a practical application is illustrated on the site of a mediaeval fortress located in Belgium. [less ▲]

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See detailA Simple Method for Thermal Characterization of Low-Melting Temperature Phase Change Materials (PCMs)
Salvador, Lucas ULg; Hastanin, Juriy ULg; Novello, Frédéric et al

in COMSOL 2016 Proceedings (2016, October)

The successful implementation of a high-efficient latent heat storage system necessitates an appropriate experimental approach to investigate and quantify the variations of the Phase Change Material (PCM ... [more ▼]

The successful implementation of a high-efficient latent heat storage system necessitates an appropriate experimental approach to investigate and quantify the variations of the Phase Change Material (PCM) thermal properties caused by its aging, as well as its potential demixing induced by cyclic freezing and melting. In this paper, we present a concept for the PCM characterization. The proposed method is relatively simple to be implemented. It consists of a cyclic cooling and melting of the PCM sample placed into a tube and monitoring its temperature evolution with a set of temperature sensors. In our work, the temperature evolution of the sample, as well as its sensitivity to the thermal parameters have been numerically investigated using the COMSOL Multiphysics® software. [less ▲]

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See detailTransparent electrodes based on silver nanowire networks: from fundamental aspects to integration into device
Sannicolo, T.; Lagrange, M.; Xian, S. et al

Conference (2016, October)

The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials which play a pivotal role in many modern devices such as: solar cells, flexible ... [more ▼]

The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials which play a pivotal role in many modern devices such as: solar cells, flexible light-emitting devices, touch screens and flexible transparent thin film heaters. Metallic nanowire networks have recently been a heavily researched subject. Currently, the most commonly used material for such applications is Tin-doped Indium oxide (ITO). Although ITO exhibits very good physical properties, indium scarcity and brittleness have prompted the search for alternative materials. Among emerging transparent electrodes, silver nanowire (AgNW) networks appear as a promising substitute to ITO since these percolating networks exhibit excellent properties with sheet resistance of a few Ω/sq and optical transparency of 90%, fulfilling the requirements for many applications. It also shows very good electro-mechanical properties. In addition, the fabrication of these electrodes involves low-temperature process steps and upscaling methods, thus making them very appropriate for future use as TE for flexible devices. Our research is focused on the fundamental understanding of the physical phenomena taking place at the scales of both the network (macroscale) and the NW-to-NW junctions (nanoscale), and on the ability of AgNW networks to be integrated as transparent electrodes for different applications. In-situ electrical measurements performed during optimisation process such as thermal annealing provide useful information regarding the activation process of the junctions. This contribution aims at presenting a short overview of the main properties and applications of metallic nanowire networks, as well as the integration in devices. [less ▲]

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See detailMise en oeuvre de l'intermédialité dans l'élaboration d'un théâtre politique
Delhalle, Nancy ULg

Conference (2016, October)

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See detailMultimodal Connectivity-Based Parcellation of the Brain
Reuter, Niels; Plachti, Anna; Genon, Sarah ULg et al

Poster (2016, October)

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See detailStudy of the effect of thin ALD oxide coatings on the stability of silver nanowire based transparent electrodes
Aghazadehchors, Sara; Nguyen, Viet; Lagrange, Mélanie et al

Poster (2016, October)

Current research on new Transparent Conductive Materials focuses on emerging materials such as carbon-based materials, graphene or metallic nanowire networks. The latter concern mainly silver nanowires ... [more ▼]

Current research on new Transparent Conductive Materials focuses on emerging materials such as carbon-based materials, graphene or metallic nanowire networks. The latter concern mainly silver nanowires (AgNW). Although AgNW networks seem to approach ITO values in terms of optical transparency and electrical sheet resistance, (90% and 10 Ω/sq respectively) [1], overcoming a rather poor thermal and electrical stability still remains a challenge. While most device fabrication processes require thermal annealing steps to optimize their electrical properties, heating can modify AgNW network morphology. Moreover, when used as transparent heaters, an electrical current induces specimen heating (due to Joule effect) and then imposing AgNW network to be resistant to heat. One way to improve thermal stability of AgNW networks is to use a thin layer of a passivating metal oxide (such as ZnO or TiO2) which induces stability improvements [2]. So far, our group has studied the effect of a thin layer of TiO2 deposited by ALD on the thermal and electrical stability of AgNWs networks. Our studies show that even a TiO2 layer as thin as 5 nm can lead to an extension of thermal stability from 270 °C to 420 °C. The oxide coating also increases the value of the electrical failure voltage. This stability enhancement comes with nearly no change in optical transparency (less than 1%). Currently we are replacing the ALD deposition method with a new approach called Spatial ALD (SALD). This technique does not require vacuum, it is much faster than conventional ALD and is easily scalable [3]. Here we will present a comprehensive study of the effect of deposition parameters, passivation film thickness on the electrical and optical properties of AgNWs based transparent electrodes. Optimized parameters will allow the integration in devices such as transparent heaters. We will demonstrate that adding a passivation layer increases the breakdown voltage, making the devices stable at higher voltage or temperature. References: [1] Lagrange, M., Langley, D. P., Giusti, G., Jiménez, C., Bréchet, Y., & Bellet, D. (2015). Optimization of silver nanowire-based transparent electrodes: effects of density, size and thermal annealing. Nanoscale, 7(41), 17410- 17423. [2] Kim, A., Won, Y., Woo, K., Kim, C. H., & Moon, J. (2013). Highly transparent low resistance ZnO/Ag nanowire/ZnO composite electrode for thin film solar cells. ACS nano, 7(2), 1081-1091. [3] Muñoz-Rojas, D., & MacManus-Driscoll, J. (2014). Spatial atmospheric atomic layer deposition: a new [less ▲]

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See detailOceanBrowser: on-line visualization of gridded ocean data and in situ observations
Barth, Alexander ULg; Watelet, Sylvain ULg; Troupin, Charles et al

Conference (2016, October)

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See detailGestion du stress professionnel : sensibilisation aux processus psychologiques et outils de gestion dérivés
Brouette, Béatrice ULg; Stassart, Céline ULg; Dethier, Marie ULg et al

in Etienne, Anne-Marie; Bragard, Isabelle (Eds.) Evolutions sociales, Innovations et Politiques: nouvelles questions et nouveaux enjeux pour la psychologie de la santé. (2016, October)

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See detailInvestigating the potential of Cymodocea nodosa (Ucria) Ascherson as a coastal carbon sink coupling marine habitat cartographies and in situ nondestructive sampling
Abadie, Arnaud ULg; Richir, Jonathan ULg; Pieraccini, Riccardo ULg et al

Poster (2016, October)

Seagrass meadows are major carbon sinks, trapping about 10% of the total CO2 sequestrated in the oceans. In the Mediterranean, a major focus has been made on the climax species Posidonia oceanica (L ... [more ▼]

Seagrass meadows are major carbon sinks, trapping about 10% of the total CO2 sequestrated in the oceans. In the Mediterranean, a major focus has been made on the climax species Posidonia oceanica (L.) Delile, while other species remained little studied. In the framework of the STARECAPMED project, we thus chose to study Cymodocea nodosa (Ucria) Ascherson, a pioneer species with a rapid turnover and an expected high stocking capacity. Furthermore, the area covered by that species has been largely underestimated. In order to fill these two knowledge gaps, we first mapped all seagrass habitats within a Mediterranean bay (Calvi, Corsica, France) using side scan images, aerial photographs and ground truths. This cartography was followed by seasonal in situ density measurements and non-destructive shoot sampling (leaf cutting). Samplings were performed at different depths (5 to 23 m depth) in 6 contrasted stations (small patchy meadows to continuous beds) in order to cover all the existing facies of the bay. Elementary contents (carbon, nitrogen and stable isotope ratios) were measured in laboratory. This first work shows that C. nodosa meadows in Calvi Bay cover an area of 0.498 km2. Carbon stocks of the leaves reached 0.25 tons in winter and 2.72 tons in summer. Their nitrogen contents showed a marked seasonality with a maximum value of 0.020 mgN.m-2 in July and a minimum value of 0.005 mgN.m-2 in March. Some modifications in the trophic conditions of the water column at several stations were put in an obvious through the N stable isotopes values, mostly during the summer period. The actual underestimation of the area covered by that species in Calvi Bay has been properly mapped thanks to side scan sonar techniques revealing, together with elementary content analysis, its importance in the carbon balance of coastal areas. [less ▲]

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See detailPotential for Composite Analysis in the Black Sea
Capet, Arthur ULg; Mason, Evan; Troupin, Charles et al

Conference (2016, October)

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See detailUsing PCB signatures and enantiomer fractions for source identification and to age date exposure
Megson, D; Focant, Jean-François ULg; Patterson, D et al

Conference (2016, October)

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See detailRegulation of breast carcinoma cell proliferation and apoptosis by type I collagen aging and 3D confinement involves differential activation of DDR1
Saby, Charles; Rammal, Hassan; Magnien, Kevin et al

Poster (2016, October)

During breast carcinoma development, cells are confronted to a type I collagen-rich environment which induces anti-proliferative and pro-apoptotic effects (Maquoi et al., Oncogene, 2012). These effects ... [more ▼]

During breast carcinoma development, cells are confronted to a type I collagen-rich environment which induces anti-proliferative and pro-apoptotic effects (Maquoi et al., Oncogene, 2012). These effects occurred only in 3D cell matrix and involved Discoidin Domain Receptor 1 (DDR1) but not β1 integrin (Assent et al., PlosOne, 2015). During aging, type I collagen undergoes post-translational modifications which have a detrimental effect on type I collagen fibrillar organization (Aït-Belkacem, J Biomed Optics, 2012 ; Guilbert et al., Oncotarget, 2016). This property is well known to be requested to activate DDR1. Here, we address the effect of type I collagen aging on cell proliferation inhibition and apoptosis induction in breast carcinoma cells in 3D cell confinement system. Type I collagen was extracted from tail tendons of 2 months (adult) and 2 years (old) rats, and MCF-7 and ZR-75-1 cells were used as an experimental model. We provide evidence for a decrease in cell proliferation by adult collagen but not by old one. This effect involves a higher phosphorylation of DDR1 by adult collagen when compared to the old one. Inhibition of DDR1 kinase activity by the specific inhibitor DDR1-IN-1 induced an increase in cell proliferation to a level similar to that observed in old collagen. An increase in cell proliferation was also observed using siRNA targeting DDR1 mRNA. At the opposite of old collagen, adult collagen was also able to trigger apoptosis by inducing an increase in expression of the pro-apoptotic protein (BIK). Inhibition of DDR1 kinase activity induced a decrease in BIK expression and apoptosis. Our data support the concept that aging contributes to the loss of the growth suppression and apoptotic effect of collagen on breast carcinoma, but only in 3D cell confinement model, by inactivating the DDR1-BIK signaling axis via a downregulation of DDR1 activation. [less ▲]

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See detailFaut-il suivre par IRM hypophysaire les patients porteurs de macroprolactinome dont l'hypersécrétion est contrôlée médicalement ?
Eroukhmanoff, J; Tejedor, I; Potorac, Iulia ULg et al

in Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie (2016, October)

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See detailLRP4 mutations in bilateral renal agenesis with severe limb deficiencies
JACQUINET, Adeline ULg; LEE, Anna F.; SWENERTON, Anna et al

Poster (2016, October)

Introduction : Severe limb deficiencies have been reported in association with bilateral renal agenesis in several syndromes. Recently, truncating mutations in LRP4 have been associated with a lethal ... [more ▼]

Introduction : Severe limb deficiencies have been reported in association with bilateral renal agenesis in several syndromes. Recently, truncating mutations in LRP4 have been associated with a lethal autosomal recessive form of Cenani-Lenz syndrome (CLS). The objectives of our study was to delineate the phenotype of the third fetus, and through a search of syndromes, identify a group of disorders with overlapping phenotypes that may be allelic with CLS or due to mutations in the same pathway. Results : A male fetus at 22 weeks’ gestation was found to have bilateral renal agenesis by ultrasound. The pregnancy was interrupted and autopsy and skeletal survey revealed shortening of forearms and legs below the knees, radioulnar synostosis, foreshortened triangular shaped tibia and fibula, and oligosyndactyly with disorganized metacarpals, metatarsals and phalanges. Bilateral renal agenesis, absent ureters and small bladder were confirmed. Additional features included downslanting palpebral fissures, high-arched palate, small mouth, low-set and posteriorly rotated ears, nuchal oedema, pulmonary hypoplasia, hypospadias and absent olfactory nerves. An autosomal recessive disorder was suspected, given a prior obstetric history of termination at 18 weeks for unilateral limb anomalies and cleft lip. Based on the aforementioned renal and limb anomalies, the lethal form of CLS was considered. Sequencing of LRP4 identified a paternally inherited variant (c.919+3G del) and a maternally inherited variant (c.4808T>A ;p.Ile1603Val). Both variants were rare in the general population and bioinformatically predicted to be damaging. We compared the phenotype with the two previously reported fetuses as well as with syndromes and disorders that may present prenatally with genitourinary anomalies plus acromesomelia of upper and lower limbs. We found significant overlap with a subset of cases of acro-renal-uterine-mandibular syndrome presenting with high-arched palate plus or minus micrognathia and microglossia, severe limb anomalies affecting the middle and distal segments, oligosyndactyly, renal agenesis, uterine anomalies and absence of olfactory nerves. Conclusion : Based on the clinical features seen in three lethal cases of CLS, we propose that acro-renal-uterine-mandibular syndrome may be allelic with CLS or due to mutations in the molecular pathway involving LRP4. [less ▲]

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See detailUsing images to analyze images. Semiotics meets Cultural Analytics
Dondero, Maria Giulia ULg

in Reyes-Garcia, Everardo; Châtel-Innocenti, Pierre; Zreik, Khaldoun (Eds.) Archiving and Questioning Immateriality - Proceedings of the 5th Computer Art Congress (2016, October)

In our text we examine image visualizations generated from big collections of archived images produced by Lev Manovich and his team in the field of Cultural Analytics. Our aim is to examine how these ... [more ▼]

In our text we examine image visualizations generated from big collections of archived images produced by Lev Manovich and his team in the field of Cultural Analytics. Our aim is to examine how these image visualizations function as analysis-images from two correlated perspectives of one semiotic approach: 1. Enunciation. What point of view is conveyed by the image visualizations about the computer-manipulated archive images? 2. Rhetorical/mereological composition: What is the mereological relation between the final visualization and the multitude of images that it contains, filters, or manipulates? [less ▲]

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See detailAgent-based analysis of dynamic access ranges to the distribution network
Mathieu, Sébastien ULg; Ernst, Damien ULg; Cornélusse, Bertrand ULg

in Proceedings of the 6th European Innovative Smart Grid Technologies (ISGT) (2016, October)

There is a need to clearly state an interaction model that formalizes interactions between actors of the distribution system exchanging flexibility. In previous works we quantitatively evaluated the ... [more ▼]

There is a need to clearly state an interaction model that formalizes interactions between actors of the distribution system exchanging flexibility. In previous works we quantitatively evaluated the performance of five interaction models devised with industrial partners using the agent-based testbed DSIMA. Simulation results showed that these interaction models relying on active network management suffer from a lack of coordination between the distribution and the transmission system operator, activating flexibility simultaneously in opposite directions. This paper introduces a new interaction model fixing this issue based on dynamic access bounds to the network changing throughout the day and preventing the activation of flexibility leading to congestions. This new interaction model is implemented in DSIMA and compared to a model restricting the grid users to a very restrictive but safe access range. Results show that this new model allows to safely increase by 55% the amount of distributed generation in the network. [less ▲]

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See detailPrésentation de l'Atlas national de Belgique - versions 1 à 3 et version numérique
Van Hecke, Etienne; Binard, Marc ULg; Donnay, Jean-Paul ULg

Conference (2016, September 30)

This presentation is divided into 3 parts: The "paper" version of the National Atlas, from the first to the third edition. The digital version of the National Atlas. A presentation of Geomatics Unit of ... [more ▼]

This presentation is divided into 3 parts: The "paper" version of the National Atlas, from the first to the third edition. The digital version of the National Atlas. A presentation of Geomatics Unit of the University of Liege, and its role in the realization of the 3rd edition of the National Atlas and its digital version. [less ▲]

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See detailRésultats d'une enquête sur la diffusion des thèses en droit
Bouhon, Frédéric ULg

Conference (2016, September 30)

Cette interviention, destinée aux doctorants et aux jeunes docteurs en droit, visait à présenter les résultats d'une enquête menée par l'auteur sur la diffusion des thèses en droit. Il s'agissait de ... [more ▼]

Cette interviention, destinée aux doctorants et aux jeunes docteurs en droit, visait à présenter les résultats d'une enquête menée par l'auteur sur la diffusion des thèses en droit. Il s'agissait de présenter les tendances suivies par les docteurs récemment diplômés dans les facultés de droit de Belgique francophone. L'intervention a été suivie d'un débat avec le public ainsi qu'avec des éditeurs présents. [less ▲]

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See detailDesign of an experimental set-up to analyse compliant mechanisms used for the deployment of a panel
Dewalque, Florence ULg; Bruls, Olivier ULg

in Proceedings of the 14th European Conference on Spacecraft Structures, Materials and Environmental Testing (ECSSMET) (2016, September 30)

Due to their high complexity, compliant mechanisms require high-fidelity mechanical models to reach a detailed understanding of their characteristics and predict their actual behaviour in various ... [more ▼]

Due to their high complexity, compliant mechanisms require high-fidelity mechanical models to reach a detailed understanding of their characteristics and predict their actual behaviour in various situations. This work focuses on tape springs which are used as an alternative to common mechanisms composed of kinematic joints. They present several assets such as, among others, passive deployment and self-locking, but they are characterised by a highly nonlinear behaviour including buckling, the formation of folds and hysteresis. An experimental set-up is then designed to gather information on these phenomena, while in parallel an equivalent finite element model is developed. Quasi-static and dynamic tests are performed, as well as small amplitude vibration tests and large amplitude deployments in order to collect data in a broad variety of cases. The post-processing of the numerous raw data shows, with the help of statistical considerations, the good quality of the acquisitions. Finally, the finite element model proves to be fairly well correlated to the experimental results. [less ▲]

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See detailUsing a dynamic vegetation model for future projections of crop yields: simulations from the plot scale to the Belgian and European scales
Jacquemin, Ingrid ULg; Dury, Marie ULg; Henrot, Alexandra-Jane ULg et al

Conference (2016, September 29)

Dynamic vegetation models (DVM), such as CARAIB (“CARbon Assimilation In the Biosphere”) were initially designed to describe the dynamics of natural ecosystems as a function of climate and soil with the ... [more ▼]

Dynamic vegetation models (DVM), such as CARAIB (“CARbon Assimilation In the Biosphere”) were initially designed to describe the dynamics of natural ecosystems as a function of climate and soil with the aim of studying the role of vegetation in the carbon cycle. But their characteristics allow numerous other applications and improvements, such as the development of a crop module. This module can be validated at the plot scale, with the use of eddy-covariance data from agricultural sites in the FLUXNET network. The carbon fluxes (e.g., net ecosystem exchange (NEE), gross primary productivity (GPP)) and the evapotranspiration (ET) simulated with the CARAIB model are compared with the fluxes measured at several sites, in order to cover a maximum number of crop types (winter wheat/barley, sugar beets, potatoes, rapeseed,…) and to evaluate the model for different European regions (Belgium, France, Germany,…). The aim of this validation is to assess the model ability to reproduce the seasonal and inter-annual variability of carbon fluxes. In order to assess the spatial variability of the model, CARAIB will be applied over Belgium and forced with the outputs the regional climate model ALARO (4 km resolution), for the recent past and the decennial projections. To reach the larger scale, we also aim to assess crops yields over Europe and to quantify the uncertainties in the climatic projections. CARAIB will be driven with the outputs of different regional climatic models (RCMs), nested in CMIP5 GCM projections for the EURO-CORDEX project: ALADIN53 (Météo-France/CNRM), RACMO22E (KNMI), RCA4 (SMHI) and REMO2009 (MPI-CSC) RCMs. These climatic projections are at a high spatial resolution (0.11-degree, ≈12 km). The model will be set up for the most common crops in Europe and for simulations tests with marginal and/or new crops. Finally, this simulation ensemble will be used to highlight potential changes in the most productive areas of Europe. [less ▲]

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See detailInfections de la shère génitale
MELIN, Pierrette ULg; DESCY, Julie ULg; MEEX, Cécile ULg

in MELIN, Pierrette; POLET, Marianne (Eds.) Les infections de la sphère génitale. Bruxelles, Belgique (2016, September 29)

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See detailTransition to parenthood of lesbian parents: key processes and clinical implications
Scali, Thérèse ULg; D'Amore, Salvatore ULg; Haxhe, Stéphanie ULg et al

Conference (2016, September 29)

The transition to parenthood is a key process for understanding the development of family relationships in a systemic perspective. This process has been studied mostly in heterosexual families but very ... [more ▼]

The transition to parenthood is a key process for understanding the development of family relationships in a systemic perspective. This process has been studied mostly in heterosexual families but very few studies focus on families with same-sex families. This exploratory study analyzes the key passages of the transition from 17 lesbian headed families through a quantitative analysis of socio-demographic data, information about the coming-out, pair formation, project of the child, the child's arrival, as well as social and cultural pressures towards family and stressors. The main results show that the decision making to become parents is generally harmonious (70%) between the members of the couple, and only a few had substantial conflicts (17,1%). Moreover, the motivation to become parents seems to be stronger for the mother who carried the child (57, 1%)than for the social mother. The majority of the lesbian mothers reported no medical homophobia (64,3%) Regarding the caregiving tasks, they seem to be equally shared between social and biological mothers. In regards to the child, almost 70% are aware of their parents’ sexual orientation (as only 5.7% are not fully aware). Finally, no changes in the quality of relationship with the family of origin have been found after the birth of the baby. Clinical implications of these results will be discussed. [less ▲]

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See detailWho are the winners in the race against desiccation – phenotypic plasticity in a fossorial toad
Székely, Diana ULg; Székely, Paul; Denoël, Mathieu ULg et al

Conference (2016, September 29)

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See detailStructure of the classe D β-lactamase OXA-29, an original dimer
Kerff, Frédéric ULg

Conference (2016, September 29)

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See detailProphéties, lyrisme et chevalerie. Portrait de Jacques Le Gros, bourgeois de Paris († 1551)
Lambert, Adélaïde ULg

Conference (2016, September 29)

Notre communication consistait à analyser les documents qui encadrent la fresque épique Gerard du Frattre dans le manuscrit unique Paris, BnF, fr. 12791, copié intégralement de la main de Jacques Le Gros ... [more ▼]

Notre communication consistait à analyser les documents qui encadrent la fresque épique Gerard du Frattre dans le manuscrit unique Paris, BnF, fr. 12791, copié intégralement de la main de Jacques Le Gros, un marchand de soie parisien. Outre la table des matières de Gerard du Frattre, ce corpus est notamment composé d’un inventaire de la bibliothèque de Jacques Le Gros, de prophéties portant sur des événements politiques contemporains (entre autres, sur les guerres opposant François Ier à Charles Quint), de pièces de vers amoureuses, satiriques ou pieuses, d’un placard affiché sur les portes de Notre-Dame, etc. Copiés entre 1525 et 1545 puis rassemblés dans un même codex, ces documents constituent un témoignage exceptionnel sur les intérêts d’un bourgeois de Paris et, plus largement, sur ceux du public des réécritures médiévales, durant la première moitié du XVIe siècle. En guise de prolongement, les résultats de notre enquête pourront alimenter la question de l’influence qu’a pu exercer le contexte politique et social du début du siècle sur la refonte des légendes médiévales : les pièces qui accompagnent Gerard du Frattre peuvent-elles être considérées comme des éléments paratextuels susceptibles d’orienter l’interprétation de la fiction placée au centre du manuscrit ? [less ▲]

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See detailInfluence of environmental factors on food intakes of nursing home residents: a survey combined to a video approach
Buckinx, Fanny ULg; Morelle, Alisson; Adam, Stéphane ULg et al

Conference (2016, September 29)

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See detailINNOVATIVE INJECTABLE LIPOSOME AND DRUG-IN-CYCLODEXTRIN-IN LIPOSOME SYSTEMS ENCAPSULATING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES
Palazzo, Claudio ULg; Laloy, Julie; Delvigne, Anne-Sophie et al

Conference (2016, September 28)

Purpose: In 2010, almost 15 million of babies in the world are prematurely borned, 11.1 % of the total amount of alive children. Despite the better neonatology techniques, the number of preterm babies ... [more ▼]

Purpose: In 2010, almost 15 million of babies in the world are prematurely borned, 11.1 % of the total amount of alive children. Despite the better neonatology techniques, the number of preterm babies with motor, vision, hearing or mental deficiencies is still constant along the last twenty years. Moreover, no efficacy treatment is available to the present day. The estetrol (E4) has an important role in the brain development and protection. The aim of this study is to develop new injectable liposome and drug-in-cyclodextrin-in-liposome (DCL) formulations, encapsulating E4 in order to enhance its crossing through the blood-brain barrier (BBB). Methods: Hydroxypropyl-β-cyclodextrins (degrees of substitution 0.87 and 0.63) (HPβCD 0.87 and HPβCD 0.63) were used to increase E4 aqueous solubility. Liposome and DCL (E4-HPβCD 0.63 complex) formulations were prepared by thin-film hydration technique. The formulations were physicochemical characterized and stability in foetal bovine serum (FBS) was evaluated. LDH and MTS tests on endothelial, neuronal and BBB model cells were performed in vitro on the liposome formulation. Hemocompatibility of the formulations was evaluated on red blood cells, platelet aggregation and coagulation. BBB passage tests were performed using human BBB cell line (hCMEC/D3). Results: E4-HPβCD complexes proportionally increased the solubility of the hormone. Due to the lower solubility obtained with HPβCD ds 0.87, only HPβCD ds 0.63 was retained for future tests. Liposomes and DCL encapsulating E4 were prepared. All the formulations had average particle size below 150 nm, polydispersity index below 0.10 and ζ potential around + 30 mV. The encapsulation efficacy for liposomes was between 3% and 10% while those of DCL are between 15% and 35%. Moreover, the formulations are capable to release 80 % (liposome) and 90 % (DCL) of encapsulated E4 after 3 h at 37°C. The formulations, incubated in FBS at 37°C under gentle stirring, keep the same size and do not form protein corona up to 6 h. The effect of liposome and DCL formulations on cell viability and integrity was evaluated. The results showed no toxic effects on all the tested cell lines. Hemocompatibility tests showed no hemolysis, platelet aggregation or effects on coagulation, confirming the possibility of the formulations to be intravenously administrated. Preliminary BBB passage tests highlighted the capability of the formulations to pass the BBB and reach the brain. Conclusions: New non-toxic, hemocompatible liposome and DCL formulations encapsulating E4 were prepared. The formulations are promising drug delivery system to target estrogens to the brain, due to their physiochemical characteristics. Aknowledgment : The authors thank Estetra SPRL for providing Estetrol. [less ▲]

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See detailSystème d’exploitation et potentialités économiques des cuvettes oasiennes du sud-est du Niger
Malam Boukar, Awa Krou; Yamba, Boubacar; Lebailly, Philippe ULg

Poster (2016, September 28)

Les cuvettes oasiennes du sud-est nigérien sont sources de production alimentaire (JAHIEL. 1998). C’est pourquoi, les populations locales sont dépendantes des cuvettes pour leurs productions alimentaires ... [more ▼]

Les cuvettes oasiennes du sud-est nigérien sont sources de production alimentaire (JAHIEL. 1998). C’est pourquoi, les populations locales sont dépendantes des cuvettes pour leurs productions alimentaires et leurs revenus (TYCHON B. et al. 2009). Cette étude vise à démontrer l’importance socio-économique des cuvettes oasiennes du sud-est nigérien. [less ▲]

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See detailEvolution récente des extrêmes pluviométriques au Niger (1950-2014)
Ozer, Pierre ULg; Laminou, Manzo Ousmane; Tidjani, Adamou Didier et al

Conference (2016, September 28)

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See detailPratiques foncières dans les cuvettes oasiennes du Niger oriental
Malam Boukar, Awa Krou; Yamba, Boubacar; Ouassa, Tiekoura et al

Conference (2016, September 28)

La situation foncière en Afrique de l’Ouest francophone rurale se caractérise par la coexistence de différents systèmes de normes : aux règles foncières sociales, issues d’hybridations successives, se ... [more ▼]

La situation foncière en Afrique de l’Ouest francophone rurale se caractérise par la coexistence de différents systèmes de normes : aux règles foncières sociales, issues d’hybridations successives, se superpose un système juridique et réglementaire étatique (LAVIGNE Ph. 2000). L’Etat du Niger s’est engagé depuis les années 80 dans un processus visant à mettre en place des règles de gestion durable du foncier à travers le Code rural (Code Rural du Niger. 2013). De ce fait, la mise en perspective des spécificités des cuvettes oasiennes du Niger oriental ainsi que le cadre législatif devant permettre de gérer théoriquement le foncier est d’un intérêt croissant étant donné le nombre de problèmes récurrents et conjoncturels dans cette zone (ensablement, pression démographique, conflit foncier, enclavement). À la suite de ces constats, la mise en place de notre protocole de recherche tente d’établir un état des lieux du mode de fonctionnement et d’accès aux cuvettes oasiennes. La question de recherche s’énonce comme suit : « Comment s’effectue la pratique foncière dans les cuvettes oasiennes du département de Gouré ? ». La principale hypothèse du travail repose sur le fait que l’ensemble des cuvettes oasiennes du département de Gouré ont une gestion foncière relativement dépendante des chefs coutumiers et que ces derniers ne sont pas impliqués dans le processus du Code Rural Nigérien. [less ▲]

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See detailMathematical modelling of ectopic bone formation in bone morphogenetic (BMP) carrier device
Manhas, Varun ULg; Carlier, Aurelie; Geris, Liesbet ULg

Conference (2016, September 28)

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See detailPerformance et circuit de commercialisation des principaux produits agricoles des cuvettes oasiennes du département de Gouré
Malam Boukar, Awa Krou; Yahaya, Abdou; Yamba, Boubacar et al

Conference (2016, September 28)

Les cuvettes oasiennes du département de Gouré sont sources de production alimentaire et de revenus pour les populations locales. Elles jouent un rôle important dans la lutte contre l’insécurité ... [more ▼]

Les cuvettes oasiennes du département de Gouré sont sources de production alimentaire et de revenus pour les populations locales. Elles jouent un rôle important dans la lutte contre l’insécurité alimentaire et la pauvreté. L’objectif de cet article est de démontrer l’efficacité économique des principaux produits agricoles de cuvettes ainsi que les plateformes de commercialisation. Pour ce faire, trois démarches méthodologiques complémentaires ont été adoptées. La première permet d’identifier les produits agricoles les plus rentables selon le point de vu des producteurs, la seconde permet déterminer les principaux produits agricoles de cuvettes à travers le « test de Kendall » et la troisième permet de calculer la rentabilité économique des produits à travers des indicateurs de performance. Pour cela, neuf cuvettes ont été choisies suivant le niveau de nappe phréatique et le type de valorisation. Les enquêtes réalisées et les constats effectués montrent que toutes les spéculations sont rentables, puisque leur RPN dépasse les 50%. Les producteurs indiquent que le manioc est la spéculation la plus importante du fait de sa mise en culture, de sa consommation et de sa conservation facile. Les deux autres tests montrent les cultures à cycle court comme le chou (75%) et l’oignon (69%) sont plus attrayants. Il est aussi ressorti que les produits agricoles de cuvettes sont plus destinés à la vente (73%) qu’à l’autoconsommation (27%) et les marchés locaux représentent les principales plateformes commerciales. [less ▲]

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See detailClimatic and management drivers of CO2 exchanges by a production crop: Analysis over three successive 4-year crop rotation cycles
Buysse, Pauline ULg; Manise, Tanguy ULg; De Ligne, Anne ULg et al

Poster (2016, September 27)

Carbon dioxide (CO2) exchanges between crops and the atmosphere are influenced by both climatic and crop management drivers. The investigated crop, situated at the Lonzée Terrestrial Observatory (LTO ... [more ▼]

Carbon dioxide (CO2) exchanges between crops and the atmosphere are influenced by both climatic and crop management drivers. The investigated crop, situated at the Lonzée Terrestrial Observatory (LTO, candidate ICOS site) in Belgium and managed for more than 70 years using conventional farming practices, was monitored over three complete sugar beet/winter wheat/potato/winter wheat rotation cycles from 2004 to 2016. Continuous eddy-covariance measurements and regular biomass samplings were performed in order to obtain the daily and seasonal Net Ecosystem Exchange (NEE), Gross Primary Productivity (GPP), Total Ecosystem Respiration (TER), Net Primary Productivity (NPP), and Net Biome Production (NBP). Meteorological data and crop management practices were also recorded. Over the 12 years, NEE was negative (-4.34 kg C m-2) but NBP was positive (1.05 kg C m-2), i.e. as soon as carbon exportation by harvest and carbon importation (manure, slimes) are included in the budget, the site behaves as a carbon source. At the crop rotation scale (4 years) it was quite remarkable to observe that NBP was very similar over the three rotations (0.30-0.36 kg C m-2), despite climatic and management differences between years. Crop type impacted carbon exchanges, with sugar beet and winter wheat crops leading to higher net carbon sequestration than seed potato crops. For one given crop, larger growth length and cumulated global radiation drove larger cumulated NEE. Net carbon emissions were observed during intercrops, but growing mustard during these periods reduced their rates and provided carbon residues to the soil. NBP values suggest that one sixth of the total soil organic carbon stock at LTO (6.23 ± 0.16 kg C m-2 in [0, 60] cm) would be lost in 12 years. Large uncertainties (mostly due to biomass measurements) affect NBP estimates, but still, this figure is huge and should encourage cultural practices returning carbon to the soil. [less ▲]

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See detailComparison of temperature from DTS and ERT with direct measurements during heat tracer experiments in heterogeneous aquifers
Nguyen, Frédéric ULg; Hermans, Thomas ULg; Jamin, Pierre ULg et al

Conference (2016, September 27)

Geothermal field characterization and heat tracer experiments often rely on scarce temperature data collected in boreholes. Electrical resistivity tomography (ERT) and distributed temperature sensing (DTS ... [more ▼]

Geothermal field characterization and heat tracer experiments often rely on scarce temperature data collected in boreholes. Electrical resistivity tomography (ERT) and distributed temperature sensing (DTS) have the potential to provide spatial information on temperature changes in the subsurface. In this contribution, we show how DTS and ERT have been used to investigate the heterogeneity of a heterogeneous aquifer during a heat tracing experiment under forced gradient conditions. Optic fibers were installed in the heat injection well and in two piezometers intersecting the main flow directions at 8 m from the injection well. These piezometers were also equipped with ERT. The DTS measurement in the injection well clearly shows the two-layer nature of the aquifer. After the end of injection, the temperature in the bottom part of the well decreases faster than in the upper part due to the higher water fluxes. Those results are confirmed by DTS measurements in natural flow conditions during a heating wire test. DTS and ERT in the cross-panel both show the vertical and lateral heterogeneity of the aquifer. Temperatures only increase significantly in the bottom part of the aquifer where advection is predominant. However, strong differences are observed laterally. ERT additionally shows that the hot plume is divided in two main flow paths, which is confirmed by direct temperature measurements. The comparison of DTS and ERT shows that one of the well is suffering from water mixing. Indeed, temperature from DTS are homogeneous over the whole tichkness of the aquifer, whereas ERT temperature, less affected by local variations, are varying. Our study demonstrate the value of spatially distributed measurements for the monitoring of heat tracer experiment and highligths the issue of multilevel sampling. The detailed temperature measurements can be subsequently used in hydrogeological model to better estimates heat flow and transport parameters. [less ▲]

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See detailDEVELOPMENT OF NOVEL CATIONIC AND LIGAND-GRAFTED ANIONIC LIPOSOMES FOR BRAIN-TARGETED DRUG DELIVERY
Karim, Reatul ULg; Palazzo, Claudio ULg; Laloy, Julie et al

Poster (2016, September 27)

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See detailLa dynamique des profondeurs. Les réinventions de l’espace dans Alice Comedies, Oswald the Lucky Rabbit et Mickey Mouse
Tomasovic, Dick ULg

Conference (2016, September 27)

Détaillant les mises en scènes de l’espace dans trois séries essentielles de l’histoire du dessin animé (Alice Comedies (1923-1927), Oswald the Lucky Rabbit (1927-1928) et Mickey Mouse (dès 1928)) comme ... [more ▼]

Détaillant les mises en scènes de l’espace dans trois séries essentielles de l’histoire du dessin animé (Alice Comedies (1923-1927), Oswald the Lucky Rabbit (1927-1928) et Mickey Mouse (dès 1928)) comme autant d’étapes dans la définition d’une nouvelle spatialité servant au mieux les créations de personnages animés d’un nouveau type, analysant précisément certaines images dans la manière dont elles articulent avant-plan et arrière-plan, cette intervention pointe également les présupposés idéologiques du simulacre de la profondeur chez Disney. Reposant plus particulièrement sur le commentaire de quelques films emblématiques tels que Alice’s Wonderland (1923), Trolley Troubles (1927), ou Plane Crazy (1928), entre autres, l’intervention, en revenant notamment sur les contributions des spécialistes de l’histoire et de l’esthétique disneyenne (Donald Crafton, Jay P. Telotte, Leonard Maltin, J.B. Kaufman…), tente d’apporter un nouvel éclairage sur l’évolution de la conception de l’espace (en tant que problème esthétique, dramatique et psychologique) dans le dessin animé industriel américain, mais aussi, indirectement et plus largement, dans l’histoire des films d’animation. [less ▲]

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See detailGenomics and ecological adaptation: metal hyperaccumulation in Arabidopsis halleri
Hanikenne, Marc ULg

Conference (2016, September 27)

Detailed reference viewed: 38 (5 ULg)
See detailUVS – JIRAM image comparison during Juno PJ1
Gérard, Jean-Claude ULg; Bonfond, Bertrand ULg; Grodent, Denis ULg et al

Conference (2016, September 27)

We present a comparison between images collected in the infrared and ultraviolet by the JIRAM and IUVS spectral imagers on board the Juno orbiter. Similarities and differences are pointed out.

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See detailInfluence of groundwater exchanges on the efficiency of Underground Pumped Storage Hydroelectricity plants using open pit mines
Pujades, Estanislao ULg; Bodeux, Sarah ULg; Orban, Philippe ULg et al

Poster (2016, September 27)

Underground Pumped Storage Hydropower (UPSH) plants can be used to manage the production of electrical energy according to the demand. These plants consist in two reservoirs, the upper one is located at ... [more ▼]

Underground Pumped Storage Hydropower (UPSH) plants can be used to manage the production of electrical energy according to the demand. These plants consist in two reservoirs, the upper one is located at the surface while the lower one is underground. The energy is stored by pumping water from the lower to the upper reservoir and produced by releasing water from the upper to the lower one. As a result, the hydraulic head in the lower reservoir varies continuously. UPSH plants interact with the surrounding aquifers exchanging groundwater. These groundwater exchanges, which play an important role in the evolution of the hydraulic head inside the underground reservoir, are a fact of concern in the selection of pumps and turbines because their efficiency varies with respect to the head difference between the two reservoirs. Therefore, the aquifer parameters should be considered in the selection of pumps and turbines. In this context, with an UPSH plant made up by an open pit mine, we study numerically (1) the influence of groundwater exchanges on the efficiency and (2) how the hydraulic head evolution varies depending on the aquifer properties. The relation among the groundwater exchanges, the efficiency of pumps and turbines and the aquifer parameters is considered by comparing the numerical results of several simulations. It is shown that groundwater exchanges are not negligible when optimizing the efficiency of UPSH plants. A priori, low hydraulic conductivity geological media were preferred to decrease interactions with the open-pit or the cavity used as lower reservoir. Taking into account the pump/turbine performance curves, it appears that, on the contrary, the global efficiency would be increased if the surrounding medium facilitates large groundwater exchanges because hydraulic head variations are softened. [less ▲]

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See detailLa fluidothérapie chez le bovin adulte
Lecomte, Denis; Casalta, Hélène ULg; Djebala, Salem ULg et al

Conference (2016, September 27)

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See detailAn old slate mine as lower reservoir for UPSH (Underground Pumping Storage Hydroelectricity)- groundwater interactions and limitations
Bodeux, Sarah ULg; Pujades, Estanislao ULg; Orban, Philippe ULg et al

Conference (2016, September 27)

Renewable energy sources have an increasing role to play in the future energy framework but their intermittence cannot afford a stable production according to the demand. Pumped Storage Hydroelectricity ... [more ▼]

Renewable energy sources have an increasing role to play in the future energy framework but their intermittence cannot afford a stable production according to the demand. Pumped Storage Hydroelectricity (PSH) is an efficient technology to store and release electricity. However, the development of new PSH plants is limited by environmental and topographic constraints. An innovative alternative consists in using old underground mines as lower reservoirs of Underground Pumped Storage Hydroelectricity (UPSH) plants. In this configuration, large amount of water is pumped and injected in underground cavities and these cyclic stresses impact the groundwater system. A hybrid 3D finite element mixing cell method is used to numerically simulate the use of an UPSH facility, in the case of an abandoned slate mine. Different scenarios are computed with varying pumping injection time-sequences. In order to assess the impact on the surrounding groundwater conditions, the resulting head evolution in the cavity and at different distances is analyzed in terms of groundwater oscillation magnitude, drawdown, and seepage into the cavity. Results show clearly the influence of the pumping injection time-sequence (rates, regularity, timing and duration of no-activity periods) on the actual head evolution in the surrounding medium and consequently on the magnitude of interactions with the cavity. For a given hydraulic conductivity of the surrounding medium (i.e. slates in this case study), the main conclusion is that the resulting interaction seepage flows (in and out of the cavity) are highly dependent on the chosen pumping injection sequences. The future impact of UPSH operation must be assessed taking this fact into account. [less ▲]

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See detailOccurrence of greenhouse gases (CO2, N2O and CH4) in groundwater of the Walloon Region (Belgium)
Jurado Elices, Anna ULg; Borges, Alberto ULg; Hakoun, Vivien et al

Conference (2016, September 27)

Carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) can be indirectly transferred to the atmosphere through groundwater discharge into surface water bodies such as rivers. However, these emissions ... [more ▼]

Carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) can be indirectly transferred to the atmosphere through groundwater discharge into surface water bodies such as rivers. However, these emissions are poorly evaluated and highly uncertain. The aim of this work is identify the hydrogeological contexts (alluvial, sandstone, chalk and limestone aquifers) and in situ conditions which are most conducive to the generation and occurrence of GHGs in groundwater at a regional scale. To this end, CO2, CH4 and N2O concentrations as well as major and minor elements were monitored (n=37 samples) in two field campaigns (09/2014 and 03/2015) in 15 groundwater bodies of the Walloon Region (Belgium). This preliminary work, which was presented in the 42st IAH conference (Rome, Italy), shown that GHG concentrations range from 5,160 to 47,544 ppm from the partial pressure of CO2 and from 0 to 1,064 nmol/L and 1 to 5,637 nmol/L for CH4 and N2O respectively. Overall, groundwater was supersaturated in GHGs with respect to atmospheric equilibrium, suggesting that groundwater contribute to the atmospheric GHGs budget. A third sampling campaign is carried out in 2016 including around 60 new groundwater samples. The combination of the results of the three campaigns allows: (1) reducing the uncertainties related to indirect emissions of GHG through groundwater-surface water interaction and (2) contributing to a better understanding of the occurrence of GHGs in aquifers. New results will be presented and discussed in detail in the presentation. [less ▲]

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See detailGroundwater flow and saltwater intrusion modelling in the Continental Terminal (CT) aquifer near the Saloum inverse estuary in Senegal
Dieng, Ndeye Maguette ULg; Orban, Philippe ULg; Dassargues, Alain ULg et al

Conference (2016, September 27)

The Saloum River hypersaline estuary (Senegal) is an ‘inverse estuary’ showing a salinity increasing from the river mouth towards inland. This salinization process is mainly driven by a net loss of ... [more ▼]

The Saloum River hypersaline estuary (Senegal) is an ‘inverse estuary’ showing a salinity increasing from the river mouth towards inland. This salinization process is mainly driven by a net loss of freshwater due to intense evaporation. In this context, interactions between the river and the surrounding aquifer of the Continental Terminal (CT) may lead to local and progressive salinization of this groundwater main resource for water supply. Our study, based on available data and new measured data in 2012 and 2013, is focused on the southern part of the Saloum basin. It confirms that the groundwater resource is threatened by local saltwater intrusions in the vicinity of the Saloum River and along the western coastal part of the aquifer. For a long term water resources management, it is thus essential to predict the future evolution of this process in a context of increasing groundwater pumping rate together with climate variability and changes. A groundwater flow model is developed using MODFLOW. Starting from a conceptual steady-state situation corresponding to the CT aquifer state in 1973 before development of pumping, a transient calibration of the groundwater flow model is performed on data from 1974 to 2012. Despite the low number of measured data, the model can be considered as the current best assessment tool for future predictions. Using the particle tracking technique (MODPATH), a first assessment of the saltwater intrusions in the aquifer is simulated (neglecting the density effect on the hydraulic conductivity) confirming the measured data. Results, for an increased pumping of 20% in 2050 combined with different climatic scenarios, are useful to assess how the saltwater intrusions will evolve in the next years. [less ▲]

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See detailLaboratory diagnosis of syphilis
HUYNEN, Pascale ULg

Conference (2016, September 26)

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See detailRelectures de La Misère du monde: Bourdieu, Sartre, Enzensberger
Cormann, Grégory ULg

Conference (2016, September 26)

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See detailSmall molecule ligands for the orphan GPR27
Dupuis, Nadine ULg; Franssen, Delphine ULg; Laschet, Céline ULg et al

Poster (2016, September 26)

Background G protein-coupled receptors (GPCRs) are involved in many physiological processes and constitute the target of around 30% of marketed therapies. Nonetheless, ~100 human GPCRs have no known ... [more ▼]

Background G protein-coupled receptors (GPCRs) are involved in many physiological processes and constitute the target of around 30% of marketed therapies. Nonetheless, ~100 human GPCRs have no known ligand and are designated as "orphan". This project focuses on GPR27, a rhodopsin-like alpha orphan of the SREB family (Super conserved Receptors Expressed in the Brain), presumably involved in the regulation of insulin secretion [1]. Methods In order to identify small molecules activating GPR27, we developed a firefly luciferase complementation assay (based on [2]) to assess the binding of ß-arrestin2 to the activated GPCR. To increase the affinity for and strengthen the interaction with ß-arrestin2, a GPR27-V2R chimera has been used for library screening. Results Small molecules activating GPR27-V2 have been identified in the DiverSetTM library (ChemBridge). After exclusion of non-specific activities using another unrelated GPCR, two compounds sharing a common scaffold with activity in the low micromolar range were selected for further investigations. We confirmed their agonist profile by performing complete concentration-response curves on our arrestin complementation assay as well as orthogonal assays. These compounds show good specificity being inactive on GPR85-V2 and GPR173-V2 (the two other SREB members). With these original tools, we characterized the recruitment of ß-arrestin2 to activated GPR27 WT. Conclusion We identified small molecule ligands for GPR27 that will serve as valuable tools for studying the pharmacology of GPR27 as well as its physiological roles, for example in insulin secretion. 1 Ku G.M., Pappalardo Z., Luo C.C., German M.S., McManus M.T. An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production. PLoS genetics. 2012, 8, e1002449. 2 Takakura H., Hattori M., Takeuchi M., Ozawa T. Visualization and Quantitative Analysis of G Protein-Coupled Receptor−β-Arrestin Interaction in Single Cells and Specific Organs of Living Mice Using Split Luciferase Complementation. ACS Chem. Biol. 2012, 7, 901−910. [less ▲]

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See detailReprise et renouvellement de la philosophie sartrienne dans le champ des sciences sociales
Recchia, Fabio ULg

Conference (2016, September 26)

L'objectif de cette communication est double. D'une part, il s'agit de définir ce que le projet sartrien d'une anthropologie structurelle et historique emprunte au structuralisme français. Nous porterons ... [more ▼]

L'objectif de cette communication est double. D'une part, il s'agit de définir ce que le projet sartrien d'une anthropologie structurelle et historique emprunte au structuralisme français. Nous porterons ainsi notre attention sur le numéro 246 de la revue "Les Temps Modernes", où Sartre (mais aussi Bourdieu et le jeune Maurice Godelier) met en question les principes fondamentaux de l'analyse structurale. D'autre part, nous souhaitons préciser en quoi la philosophie du second Sartre revisite en profondeur ces principes. Nous mobiliserons, pour ce faire, "Les Racines de l'éthique". Récemment édité dans "Les Études sartriennes", cet inédit de l'oeuvre sartrienne précise la stratégie par laquelle celle-ci entend conserver mais aussi dépasser les apories de l'analyse structurale. Aussi la problématique générale de notre communication consiste-t-elle à documenter le rapport qu'entretînt la philosophie sartrienne à l'égard d'un certain segment des sciences sociales françaises. À cette fin, nous étudierons l'activité éditoriale des "Temps Modernes", ainsi que celle qui fut générée postérieurement par le champ des "Études sartriennes". [less ▲]

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See detailRobust mission design using invariant manifolds
Dell'Elce, Lamberto ULg; Baresi, Nicola; Kerschen, Gaëtan ULg et al

in Proceedings of the 67th International Astronautical Congress (2016, September 26)

Uncertainties in the dynamical system affect all real-life applications in astrodynamics. This is particularly true for satellites orbiting about small bodies owing to their irregular shapes and to the ... [more ▼]

Uncertainties in the dynamical system affect all real-life applications in astrodynamics. This is particularly true for satellites orbiting about small bodies owing to their irregular shapes and to the difficulties in characterizing their physical properties at the early stages of a dedicated spacecraft mission. Hence, accommodating uncertainty in the orbital design process may be extremely beneficial for the success of the mission. Here, in a Lyapunov stability perspective, the properties of the invariant manifolds are exploited to generate regions of the phase space where the motion is guaranteed to evolve despite the uncertainties in the system parameters and navigation errors. Specifically, the scenario approach is applied to tackle a semi-infinite optimization problem that locates these robust regions. The methodology is illustrated with the robust design of a inner retrograde orbit about the primary of (65803) Didymos as well as with a ballistic landing on the smaller secondary body. [less ▲]

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See detailGroundwater flow and saltwater intrusion modelling in the Continental Terminal (CT) aquifer near the Saloum inverse estuary in Senegal
Faye, Serigne; Ndeye, Maguette Dieng; Orban, Philippe ULg et al

Conference (2016, September 26)

The Saloum River hypersaline estuary (Senegal) is an ‘inverse estuary’ showing a salinity increasing from the river mouth towards inland. This salinization process is mainly driven by a net loss of ... [more ▼]

The Saloum River hypersaline estuary (Senegal) is an ‘inverse estuary’ showing a salinity increasing from the river mouth towards inland. This salinization process is mainly driven by a net loss of freshwater due to intense evaporation. In this context, interactions between the river and the surrounding aquifer of the Continental Terminal (CT) may lead to local and progressive salinization of this groundwater main resource for water supply. Our study, based on available data and new measured data in 2012 and 2013, is focused on the southern part of the Saloum basin. It confirms that the groundwater resource is threatened by local saltwater intrusions in the vicinity of the Saloum River and along the western coastal part of the aquifer. For a long term water resources management, it is thus essential to predict the future evolution of this process in a context of increasing groundwater pumping rate together with climate variability and changes. A groundwater flow model is developed using MODFLOW. Starting from a conceptual steady-state situation corresponding to the CT aquifer state in 1973 before development of pumping, a transient calibration of the groundwater flow model is performed on data from 1974 to 2012. Despite the low number of measured data, the model can be considered as the current best assessment tool for future predictions. Using the particle tracking technique (MODPATH), a first assessment of the saltwater intrusions in the aquifer is simulated (neglecting the density effect on the hydraulic conductivity) confirming the measured data. Results, for an increased pumping of 20% in 2050 combined with different climatic scenarios, are useful to assess how the saltwater intrusions will evolve in the next years. [less ▲]

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See detailMUCOADHESIVE SPONGES WITH PEGYLATED LIPOPLEXES: TOWARDS A SUSTAINED VAGINAL DELIVERY OF siRNA
Furst, Tania ULg; Dakwar, Georges; zagato, Elisa et al

Poster (2016, September 26)

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See detailQuelles réponses face à la fatigue vocale? Variabilité inter-individuelle des modifications acoustiques de la voix au cours de la journée
Remacle, Angélique ULg; Gerber, Silvain; Garnier, Maëva

Poster (2016, September 26)

Objectifs: 1) décrire l’évolution de 4 indicateurs acoustiques de la fatigue vocale au cours d’une journée de travail et examiner leur universalité dans l'échantillon, 2) déterminer si différentes ... [more ▼]

Objectifs: 1) décrire l’évolution de 4 indicateurs acoustiques de la fatigue vocale au cours d’une journée de travail et examiner leur universalité dans l'échantillon, 2) déterminer si différentes typologies de réponse à la fatigue vocale peuvent être distinguées. Population: 22 enseignantes enregistrées le matin et le soir après leur journée de travail, à 3 temps de l’année: octobre, décembre, et février. Tâche: voyelle [a] tenue produite 5 fois à intensité et fréquence confortables. Paramètres mesurés avec Praat et moyennés sur les 5 répétitions: F0 (Hz), rapport harmoniques/bruit (HNR, dB), local Jitter (%), et local Shimmer (%). Les variations des moyennes entre le soir et le matin (Δ) sont calculées pour chaque paramètre. Résultats: En accord avec la littérature, le Δ moyen pour les 22 participantes aux 3 temps montre une augmentation de F0 et HNR, et une diminution de Jitter et Shimmer au cours de la journée. Cependant, ces résultats ne sont pas généralisés dans notre échantillon. Une analyse hiérarchique ascendante permet d'identifier 3 typologies de réponse à la fatigue vocale, observées suite à la journée de travail. Typologie 1: tendance inverse à la littérature (ΔF0 et ΔHNR négatifs, Δjitter et Δshimmer positifs). Comportement hypofonctionnel en réponse à la fatigue vocale. Typologie 2: tendance et amplitude similaires à la littérature (ΔF0 et ΔHNR positifs, Δjitter et Δshimmer négatifs). Réponse attendue, adaptation saine à la fatigue vocale. Typologie 3: tendance similaire à la littérature mais d’amplitude très marquée. Comportement hyperfonctionnel, suspicion d’un trouble vocal. [less ▲]

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