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See detailPancreatic Beta Cell Regeneration: Duct Cells Act as Progenitors in Adult Zebrafish
Bergemann, David ULg; Ghaye, Aurélie; Tarifeño, Estefania et al

Poster (2016, March 18)

Diabetes is characterized by the loss of insulin producing beta cells. Although different therapeutic strategies do exist, they lack precise and dynamic control of glycemia as carried out by endogenous ... [more ▼]

Diabetes is characterized by the loss of insulin producing beta cells. Although different therapeutic strategies do exist, they lack precise and dynamic control of glycemia as carried out by endogenous beta cells. One promising alternative is to replenish the pancreas with bona fide functional beta cells by triggering regeneration mechanisms. Previous studies have shown beta cell neogenesis but still remain controversial about their origin as they used different models. However, among the different hypotheses, it is tempting to assume that pancreatic ducts contain progenitor/precursor cells in adults. The latter is supported by the fact that the embryonic duct epithelium gives rise to the endocrine lineage, and that in healthy and diabetic human adults, insulin positive cells could be found next to or in pancreatic ducts. Despite these observations, mammals show very limited regenerative capabilities, making it difficult to investigate those mechanisms. In contrast, zebrafish are extensively used for regeneration studies. The ability of adult zebrafish to regenerate its beta cells and restore normoglycemia after massive beta cell ablation has already been shown. Our work focuses on the understanding of the underlying mechanisms leading to this retained potential. Here we show that adult pancreatic duct cells act as progenitors, giving rise to beta cells, in physiological and induced diabetic condition in vivo. To get insight into this process, we conducted RNA-seq experiments on zebrafish pancreatic duct cells. By this mean we could identify new ductal markers and noticed that adult duct cells also show strong expression of embryonic pancreatic progenitor markers. In our ongoing comparative analyses we are deciphering the key genes and pathways needed to set in motion the regenerative machinery. The differences between zebrafish and mammal duct cells that will thereby be underlined might then be transposed to mammalian model s to restore regenerative processes. [less ▲]

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See detailRecollection versus familiarity in normal aging and in mild cognitive impairment: Impact of test format
Gilsoul, Jessica ULg; Simon, Jessica ULg; SALMON, Eric ULg et al

Poster (2016, March 18)

Objectives. Memory retrieval typically involves a combination of recollection and familiarity. However, test format can promote one or the other process (Norman & O’Reilly, 2003). The aim of this study ... [more ▼]

Objectives. Memory retrieval typically involves a combination of recollection and familiarity. However, test format can promote one or the other process (Norman & O’Reilly, 2003). The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in mild cognitive impairment (MCI). Methods. Seventy young participants (18-30 years), 65 “younger-old” (55- 69 years), 53 “older-old” (70-85 years), and 13 MCIs (55-82 years) were enrolled. In the “forced-choice” task, they had to recognize which picture, among three, was presented during the encoding stage. In the “yes/no” task, they had to judge whether each item, successively presented, was previously seen or not. In each task, they had to give a “Remember/Know/Guess” judgment. Results. Group × Format repeated measures ANOVAs revealed that young people had better recognition performance (d’) than “younger-old”, which were better than “older-old” and MCIs. Moreover, young people used familiarity more accurately than both groups of old participants and MCIs, with MCIs being equivalent to “younger-old” and “older-old”. However, MCIs displayed a high rate of familiarity-based false alarms. The resort to recollection decreased with age and in MCIs. Finally, Group × Format interaction revealed that young people (but not the other groups) could use recollection more often in the “forcedchoice” task compared to the “yes/no” task. Conclusions. Recollection and familiarity decline progressively in healthy aging. In MCI, recollection is more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. [less ▲]

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See detailLa Province au défi de la Sixième réforme de l'État
Grandjean, Geoffrey ULg

Conference (2016, March 17)

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See detail“From another angle”: the Australian Reconciliation in Gail Jones’s Sorry and Five Bells
Belleflamme, Valérie-Anne ULg

Conference (2016, March 17)

On 26 May 2000, an estimated 250,000 people – Australian novelist and essayist Gail Jones included – walked across the Sydney Harbour Bridge in support of the Australian Reconciliation process. More ... [more ▼]

On 26 May 2000, an estimated 250,000 people – Australian novelist and essayist Gail Jones included – walked across the Sydney Harbour Bridge in support of the Australian Reconciliation process. More importantly, eight years later, Jones claimed that “in writing [her novel Sorry] [she] rehearsed [her] own concern that the reconciliation process not be forgotten – since it has certainly faded from the political agenda since the bridge walk of 2000[” (2008: 84). This and her claim that “the heartwarming Sorry Books [...] ought seriously to be considered within the genre of the poetics of political dissent, and not as casual or sentimental acts of mere signature” (2008: 164) are indicative of Jones’s writing and of her wish to subvert the stereotypical and ambiguous discursive manifestations of the Australian Reconciliation. By the same token, her novels Sorry (2007) and Five Bells (2011) offer a complex picture of the ethics of reconciliation, namely one that includes “an admission of uncertainty, a calculation of difficulty, and an awareness that justice – and human relations – is rarely written in black and white” (Jones 2008: 86). My paper will thus seek to explore how Jones, by drawing on forms of narrative indirections in both, Sorry and Five Bells, distances herself from white Australian writers who deal with the Stolen Generations in a way that seems to appropriate Aboriginal and Torres Strait Islander peoples’ experiences. Sorry and Five Bells, then, offer an alternative to standard reconciliation practices, with a view to bridging the gap between white Australia’s history and the history of the Aborigines. References: - Jones, Gail. 2008a. Sorry. London: Vintage. - Jones, Gail. 2008b. Speaking shadows: Justice and the poetic. In Just Words?: Australian Authors Writing for Justice, Bernadette Brennan (ed.). St Lucia, Qld.: University of Queensland, 76-86. - Jones, Gail. 2012. Five Bells. London: Vintage. [less ▲]

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See detail"Parcours fléchés. Seuils et traversées dans l'œuvre de Marc-Antoine Mathieu"
Belloi, Livio ULg

Conference (2016, March 17)

Cette communication se propose d'étudier "Sens" (2014), le dernier album du dessinateur français Marc-Antoine Mathieu. Plus spécifiquement, il s'agissait, conformément au thème directeur du Congrès de St ... [more ▼]

Cette communication se propose d'étudier "Sens" (2014), le dernier album du dessinateur français Marc-Antoine Mathieu. Plus spécifiquement, il s'agissait, conformément au thème directeur du Congrès de St. Louis, d'examiner l'œuvre de Mathieu sous l'angle de son dispositif péritextuel (première de couverture, prologue, couverture intérieure). [less ▲]

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See detailThe impact of cognitive reserve on recognition memory performance is dependent of the task format in healthy aging
Simon, Jessica ULg; Gilsoul, Jessica ULg; Bastin, Christine ULg

Poster (2016, March 17)

Objective: According to the cognitive reserve hypothesis (Stern, 2009), individuals who have developed a high level of reserve should resist better to the effects of aging than individuals with lower ... [more ▼]

Objective: According to the cognitive reserve hypothesis (Stern, 2009), individuals who have developed a high level of reserve should resist better to the effects of aging than individuals with lower cognitive reserve. In this study, we identified the factors of cognitive reserve that impact most memory performance in aging. Methods: 118 healthy older participants performed one yes/no recognition task and one 3-alternative forced-choice recognition task. For each recognized item, participants provided a Remember/Know/Guess judgment. Furthermore, participants completed a questionnaire assessing different aspects of cognitive reserve (level of education, occupation, physical, social, cultural and intellectual activities). We determined the moderators of cognitive reserve that explain a significant proportion of variance for each memory index through stepwise regression analyzes (p<0.05). Results: In the forced-choice test, the level of education explained positively the use of recollection and negatively the level of false alarms associated with familiarity. In the yes/no recognition task, the precision of recognition was explained positively by the physical activities. Recollection was positively explained by the physical activities and the level of education. Finally, the level of false alarms associated with familiarity was explained negatively by the level of education although the precision of the use of the familiarity is explained positively by physical activities. Conclusion: The more older adults were educated and/or were practicing physical activities, the better their recollection was. The impact of the moderators of the cognitive reserve is dependent on the format of the recognition task. [less ▲]

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See detailComment lire les textes informatifs au début du secondaire?
De Croix, Séverine ULg

Conference (2016, March 17)

Pourquoi et comment apprendre à lire les textes informatifs dans les différentes disciplines au début de l'enseignement secondaire ? Pour tenter de répondre à cette double question, l'auteure s'efforce ... [more ▼]

Pourquoi et comment apprendre à lire les textes informatifs dans les différentes disciplines au début de l'enseignement secondaire ? Pour tenter de répondre à cette double question, l'auteure s'efforce tout d'abord d'identifier les spécificités de ces textes et des modes de lecture qu'ils impliquent. Elle propose ensuite quelques repères, fondés sur différents travaux de recherche récents, quant aux pratiques et dispositifs didactiques qui y sont adaptés. [less ▲]

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See detailThe Bullshit Abstract: From Critique to Reflexive Practice
Van Oudheusden, Michiel ULg; Charlier, Nathan ULg; Claisse, Frédéric ULg

Conference (2016, March 17)

Academics use the abstract to summarize and communicate a research paper’s focus, methods, findings, and conclusions. However, not all abstracts are convincing. Many are bland, uninspired, or outright ... [more ▼]

Academics use the abstract to summarize and communicate a research paper’s focus, methods, findings, and conclusions. However, not all abstracts are convincing. Many are bland, uninspired, or outright stupid, as authors do not always know what they want to say or how to communicate complex research in the space of a few hundred words. They hence often convey the kind of “intelligent stupidity,” which Robert Musil (1937) said could hardly be “distinguished from talent, progress, hope or improvement.” By implication, abstracts are prone to contain and perpetuate “academic bullshit” (Frankfurt 2005), broadly understood as forms of academic expression that meet the stylistic academic standards but generate content that is deceptive, doubtful, or irrelevant. Taking this inherent disposition towards bullshit in the academic abstract as its entry point, this paper presents ten self-authored “bullshit abstracts,” which draw inspiration from various academic fields. Far from denouncing bullshit outright, it acknowledges the inevitable character of bullshit in academic writing (Eubanks and Schaeffer 2008). It urges academics to reflexively consider, and perform, their roles as researchers and writers in view of the challenges they face today, such as reputation management and the pressure in academia to publish or perish; and their complete lack of sensitivity to the odorous aspects of writing. [less ▲]

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See detailEnhancing the salience of perceptual fluency improves familiarity-based recognition memory in aging
Bastin, Christine ULg; Willems, Sylvie ULg

Poster (2016, March 17)

Objective. Normal aging is characterized by decreased recollection, but better preserved familiarity. Memory tasks that facilitate the use of familiarity should allow attenuating age-related differences ... [more ▼]

Objective. Normal aging is characterized by decreased recollection, but better preserved familiarity. Memory tasks that facilitate the use of familiarity should allow attenuating age-related differences in memory. The study tested two hypotheses: (1) can the reliance on familiarity during recognition memory be promoted by increasing the difference in perceptual processing fluency between old and new items; (2) can this manipulation reduce age-related difficulties in episodic memory? Methods. Twenty-four young and 24 older adults performed two verbal recognition memory tasks. In the No-Overlap task, target words and new words did not share any letter. Prior exposition to the target words thus induced increased processing fluency of the words and letters, so that fluency difference was a salient and reliable cue to discriminate between old and new words. In the Overlap task, target and new words had letters in common, so fluency cues were less useful. Recollection and familiarity was assessed with the Remember/Know/Guess paradigm. Results. There was an age effect on recollection but intact familiarity. Moreover, (1) memory performance was better in the No Overlap than the Overlap task, with a greater hit rate and a smaller false alarm rate associated with familiarity. (2) Age-related differences in recognition accuracy (hits – false alarms) were significantly attenuated in the No Overlap task compared to the Overlap task. Conclusion. These findings suggest that minimizing the perceptual similarity between targets and distractors, and thus increasing processing fluency differences, allowed to reduce the effect of age on recognition memory performance by facilitating the use of familiarity. [less ▲]

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See detailCharacterization of the impact of tillage and nitrogen fertilization on the root development of a winter wheat crop by use of NIR hyperspectral imaging combined to chemometrics
Fraipont, Guillaume ULg; Eylenbosch, Damien ULg; Fernández Pierna, Juan Antonio et al

Poster (2016, March 16)

The objective of this study is to characterize the impact of tillage management and nitrogen fertilization on the root system development of a winter wheat crop. To reach this objective, an innovative ... [more ▼]

The objective of this study is to characterize the impact of tillage management and nitrogen fertilization on the root system development of a winter wheat crop. To reach this objective, an innovative root quantification method that combines NIR hyperspectral imaging (NIR-HSI) and chemometric tools will be applied. [less ▲]

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See detailNursing student’s perception of the educational efficiency between two strategies of education: Problem Based Learning and the High-Fidelity Simulation.
Servotte, Jean-Christophe ULg; Guillaume, Michèle ULg

Conference (2016, March 16)

Introduction: The teaching’s evolution in nursing education has to answer the challenge to stimulate the student’s skills development. According to literature review, it’s necessary to compare High ... [more ▼]

Introduction: The teaching’s evolution in nursing education has to answer the challenge to stimulate the student’s skills development. According to literature review, it’s necessary to compare High-Fidelity Simulation (HFS) with other pedagogical methods. Furthermore, the comparison with Problem Based Learning (PBL) was not studied yet. Methods: Two indicators were evaluated : student satisfaction self-confidence. For this, two validated scales were used : Student Satisfaction Learning Scale and Self-Confidence in Learning Using Simulations Scale. 141 nursing’s students were involved in the study. They were exposed to the two pedagogical methods (PBL and HFS). The experience was organized according a complete cross plan. Results: The results demonstrated a higher level of the student’s confidence and the student’s satisfaction in learning for the HFS compare to PBL. Carry-over effects were study. It was concerning the teaching style (questions 3 and 5) as well as the varieties of educational tools (questions 2 and 4). The perception of the value of the PBL during the second period was systematically lower while the score obtained for the HFS for the two periods remains almost identical. Conclusion: A clear superiority of the HFS compared with the PBL is perceived by the students. This result seems to open new opportunities with the HFS method in the education nursing student. Nevertheless, research must be conducted in order to better understand the value of this new pedagogic approach. [less ▲]

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See detailEvaluation results of ECHAM-HAMMOZ
Schultz, Martin; Taraborrelli, Domenico; Franco, Bruno ULg et al

Conference (2016, March 16)

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See detailSingle-Molecule Force spectroscopy on synthetic helical Nanoarchitectures
Devaux, Floriane ULg; Li, Xuesong; Huc, Ivan et al

Conference (2016, March 16)

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See detailFoot identification from digital 3D models of lion tracks and paws
Marchal, Antoine ULg; Lejeune, Philippe ULg; De Bruyn, Nico

Conference (2016, March 15)

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See detailGel Beads to Investigate Sedimentation
Leleu, David ULg; Pfennig, Andreas ULg

Conference (2016, March 14)

Separation of liquid-liquid dispersions with multiple phases involves different interactions between the different dispersed species present in the system, which makes it difficult to predict e.g. the ... [more ▼]

Separation of liquid-liquid dispersions with multiple phases involves different interactions between the different dispersed species present in the system, which makes it difficult to predict e.g. the separation behaviour. Nevertheless such systems are relevant in chemical engineering e.g. for systems involving gas bubbles and simultaneously solid particles like in a fermentation broth. Models for describing the sedimentation behaviour as a basis for settler design are available in principle but have not been systematically validated for variation in size-distribution and e.g. density differences between the various species in the system. Thus, to design technical separation equipment, the separation process has to be better understood, which requires the study of the sedimentation as a first step. This project is focused on the interactions which may occur between each species during the sedimentation e.g. the effect on sedimentation of descending particles when they meet ascending drops. However, a proper study of the sedimentation with fluid phases is difficult due to other phenomena occurring simultaneously, e.g. coalescence. To overcome this issue, the use of gel beads is proposed, which due to their solid interface cannot coalesce. In addition, it is easy to define their parameters which are the density, the hardness and the size distribution. Besides, they can also be preserved during an extended period of time, experiments can thus be reproduced many times with identical beads. During the project, gel beads are designed with different particle size distributions and with different densities. Different batches of the produced gel beads will be mixed to simulate systems with different dispersed phases discriminated via density and different size distributions. With these multiple dispersed phases Experiments will be performed in a settling cell in order to evaluate the overall sedimentation velocity at certain hold up. Simultaneously a new method for measurement of local hold-up profile in the dispersion is tested, which allows hold-up measurement even in opaque systems. Finally sedimentation models found in the literature are compared and adapted to experimental results for predict the sedimentation of systems which involve different dispersed phases. In the presentation the new hold-up measurement will be presented together with an error analysis, experiments on the sedimentation of multiple dispersed phases and the model evaluation will be presented. [less ▲]

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See detailGetting on Board but How? Conflicting Perspectives on the Role of the Social Sciences and Humanities in Radiation Protection
Van Oudheusden, Michiel ULg; Rossignol, Nicolas ULg; Perko, Tanja et al

Conference (2016, March 14)

In Europe, science research policy is predicated on the understanding that science and technology (S&T) serve societal needs. Accordingly, European Framework Programs urge scientists and technologists to ... [more ▼]

In Europe, science research policy is predicated on the understanding that science and technology (S&T) serve societal needs. Accordingly, European Framework Programs urge scientists and technologists to give due attention to societal and ethical aspects of S&T, and to engage with social scientists and humanists when doing research and reaching out to society. Starting from these policy prescriptions and from invitations from befriended life scientists to "get on board," we explore the terms of our involvement as social scientists and humanists in a European Joint Program on radiation protection research (EJP-CONCERT). We illuminate recurring tensions between instrumental, normative, and substantive perspectives on the role of the social sciences and humanities (SSH) in radioprotection research and nuclear S&T. Our aim is to shed light on the controversial and contingent nature of integrating SSH into nuclear S&T, as actors articulate divergent assumptions and expectations about SSH and society. These expectations pertain to the value of SSH research for S&T, issues of trust and legitmacy, and different perspectives on risk and uncertainty. By rendering these tensions explicit we seek to probe the implications for SSH of developing a separate SSH Strategic Research Agenda (SRA) within radiation protection research. [less ▲]

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See detailOpening risk gouvernance with a vigilance system: lessons learned from the Blue Tongue Virus outbreak in 2006
Fallon, Catherine ULg

Conference (2016, March 14)

This contribution results from a field research by a multidisciplinary group of veterinary and political scientists and gives an analyses of the transformations of an epidemiosurveillance governance ... [more ▼]

This contribution results from a field research by a multidisciplinary group of veterinary and political scientists and gives an analyses of the transformations of an epidemiosurveillance governance system dedicated to animal diseases, when confronted to new emerging threats in the wake of global changes (Fallon et al., in Vertigo 12(3) 2012) . The research field refers to the emergence of bluetongue virus serotype 8 in 2006 in Belgium and it mobilises the results of a survey based on Delphi method involving relevant public servants and scientists, which showed that most of the means proposed by the authorities are based on the logic of known risk management. However we can identify attempts for renewal and organisational learning, especially with the proposal of a new vigilance system, which allows open discussion and reporting through the decision process. In terms of prevention and anticipation of the adverse event), these changes are intended to accommodate the surveillance system reactivity against uncertain and unforeseen events. We question the problems faced by this transformation and its potential for enriching and reconfiguring the conceptualisation of risk management which is currently dominant in the sector. Finally the article identifies two drivers for change in the governance network : by admitting the persistence of unavoidable cognitive uncertainty and by recognizing the importance for opening up arenas of expert knowledge. [less ▲]

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See detailThe roads of colouring materials: from sources to residues
Pradeau, Jean-Victor; Dayet, Laure; Salomon, Hélène ULg

Conference (2016, March 11)

Economic systems and social relationships gain an increasing complexity in prehistoric periods. Despite their symbolic value and their informative potential in these issues, colouring materials (“ochre” ... [more ▼]

Economic systems and social relationships gain an increasing complexity in prehistoric periods. Despite their symbolic value and their informative potential in these issues, colouring materials (“ochre”, iron oxi(hydrxi)des, cinnabar, etc.) had received scant attention compare to obsidian, flint, metals or igneous rocks. Since the 2000’s, trace elemental analysis (PIXE, XRF, INAA, ICP-MS) and petrographic studies give keys to collect gitological and sourcing data. This methodology has recently improved quantitative knowledge on colouring material’s acquisition modalities and on global technic system itself. Contrasting situations are indeed highlight: archaeological corpus may consist of several raw colouring materials, unequally shared, providing from site range, close diffusion area or far diffusion area. Furthermore, the status of the different geomaterials, the diffusion modalities – direct acquisition, direct or indirect exchanges – and the identity of exporters, transporters and receivers (if any) stay unclear. Two main topics should liven up this session: a fruitful debate on different methodologies depending on geographical contexts and diachronic revue of colouring material procurement through the lens of cultural contexts and site’s status. [less ▲]

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See detailAgeism and communication in oncology
Schroyen, Sarah ULg; Adam, Stéphane ULg; Marquet, Manon ULg et al

Poster (2016, March 11)

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See detailThe Macroeconomics of PAYG Pension Schemes in an Ageing Society
Artige, Lionel ULg

Conference (2016, March 10)

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See detailTransient neonatal diabetes mellitus due to paternal uniparental disomy of chromosome 6.
FUDVOYE, Julie ULg; Farhat, Khaldoun; Nicolescu, Ramona

Conference (2016, March 10)

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See detailL'ENMG...c'est le pied
WANG, François-Charles ULg

Conference (2016, March 10)

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See detailIntroduction au séminaire
Francois, Jeromine ULg; Regibeau, Julien ULg

Conference (2016, March 09)

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See detailSpecialization SIAMU : past, present and future
Servotte, Jean-Christophe ULg

Conference (2016, March 08)

Présentation de l'histoire de la spécialisation SIAMU avec un focus sur la simulation.

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See detailMOOCs in business administration - An overview of assessment practice
Gherib, Camelia; Dujardin, Jean-Marie ULg; Verpoorten, Dominique ULg

in Proceedings of the Conference of the European Association for Practitioner Research on Improving Learning (EAPRIL) 2015, Issue 2 (2016, March 07)

The study explores 31 MOOCs in the field of business administration, equipped with a conceptual framework documenting 18 facets of assessment design. As a second step, the data collected on 3 MOOCs about ... [more ▼]

The study explores 31 MOOCs in the field of business administration, equipped with a conceptual framework documenting 18 facets of assessment design. As a second step, the data collected on 3 MOOCs about assessment is submitted to university members in charge of external courses accreditation procedures in order to ascertain its possible influence on their decision to credit a MOOC or not. Main results indicate that, a) the typical profile of the assessment procedure for MOOCs in business administration is: QCM-based, automatic, continuous, individual, product-centred, standardized, b) secure ways (proctoring, test-centres) to warrant learners’ identity for the tests can already be found in some MOOCs of this field, and c) concerns of course accreditors bear first and foremost on these student authentication aspects. [less ▲]

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See detailThe Many AUrorae of Jupiter : Auroral Ffilaments, Flares, Transient features of the main oval, Swirls, Polar dawn spots, Injection signatures and Satellite footprints
Bonfond, Bertrand ULg

Conference (2016, March 07)

The presentation is a review of the many features of the Jovian aurorae in the frame of the imminent arrival of the Juno spacecraft around Jupiter, with a special focus on the most recent results.

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See detailMOOCs in business administration - An overview of assessment practice
Gherib, Camelia; Dujardin, Jean-Marie ULg; Verpoorten, Dominique ULg

in Proceedings of the Conference of the European Association for Practitioner Research on Improving Learning (EAPRIL) 2015, Issue 2 (2016, March 07)

The study explores 31 MOOCs in the field of business administration, equipped with a conceptual framework documenting 18 facets of assessment design. As a second step, the data collected on 3 MOOCs about ... [more ▼]

The study explores 31 MOOCs in the field of business administration, equipped with a conceptual framework documenting 18 facets of assessment design. As a second step, the data collected on 3 MOOCs about assessment is submitted to university members in charge of external courses accreditation procedures in order to ascertain its possible influence on their decision to credit a MOOC or not. Main results indicate that, a) the typical profile of the assessment procedure for MOOCs in business administration is: QCM-based, automatic, continuous, individual, product-centred, standardized, b) secure ways (proctoring, test-centres) to warrant learners’ identity for the tests can already be found in some MOOCs of this field, and c) concerns of course accreditors bear first and foremost on these student authentication aspects. [less ▲]

Detailed reference viewed: 281 (5 ULg)
See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

Poster (2016, March 04)

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See detailEuthanasie et don d'organes
DETRY, Olivier ULg

Conference (2016, March 04)

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See detailPropositions pour penser la notion d'erreur en photographie
Havelange, Carl ULg

Conference (2016, March 04)

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See detailParameter Correlation Analysis in Four Mathematical Models of Left Ventricular Relaxation
Pironet, Antoine ULg; MORIMONT, Philippe ULg; Dauby, Pierre ULg et al

in 14th Belgian Day on Biomedical Engineering (2016, March 04)

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in 14th Belgian Day on Biomedical Engineering (2016, March 04)

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See detailRepeated Behavioral Assessments in Patients with Disorders of Consciousness
Wannez, Sarah ULg; Annen, Jitka ULg; Aubinet, Charlène ULg et al

Conference (2016, March 04)

The Coma Recovery Scale Revised (CRS-R) is considered as the most sensitive scale to assess patients with disorders of consciousness (DOC). Guidelines recommend repeated assessments because patients might ... [more ▼]

The Coma Recovery Scale Revised (CRS-R) is considered as the most sensitive scale to assess patients with disorders of consciousness (DOC). Guidelines recommend repeated assessments because patients might suffer from consciousness fluctuations, but it is not specified how many assessments are needed. The present study included 131 patients with DOC. They have been assessed at least 6 times during a 14-days period with the CRS-R. Results show that 5 CRS-R assessments are needed to reach a reliable diagnosis, and that all the CRS-R subscales are influenced by consciousness fluctuations. We here showed that consciousness fluctuations influence the behavioral diagnosis, and that 5 assessments within a short period of time are needed to get a reliable clinical diagnosis. [less ▲]

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See detailRelative positioning with Galileo E5 AltBOC code measurements
Deprez, Cécile ULg

Conference (2016, March 03)

Depuis une dizaine d’années, l’Europe développe son propre système de positionnement par satellites (ou Global Navigation Satellites System (GNSS) en anglais), connu sous le nom de Galileo. À la pointe de ... [more ▼]

Depuis une dizaine d’années, l’Europe développe son propre système de positionnement par satellites (ou Global Navigation Satellites System (GNSS) en anglais), connu sous le nom de Galileo. À la pointe de la technologie, les horloges atomiques embarquées à bord de ses satellites ainsi que les signaux transmis par ces derniers sont extrêmement prometteurs dans beaucoup de domaines. Bien que toujours en phase de test à l’heure actuelle, ce système a déjà conduit à de premières mesures, notamment en matière de positionnement. Parmi ces nouvelles technologies, un signal en particulier semble très prometteur : Galileo E5, aussi appelé Galileo E5a+b ou encore Galileo E5 AltBOC. Ce signal permet d’effectuer des mesures de code et de phase plus précises. Il est également moins sensible au multi-trajet. Grâce à ses caractéristiques innovantes, Galileo E5 devrait permettre d’estimer des positions avec une précision supérieure à tous les autres signaux utilisés aujourd’hui. Une étude comparative des positions estimées avec les systèmes GPS (américain) et Galileo (européen) sur leurs différentes fréquences émises (GPS L1, GPS L2, GPS L5 pour GPS et Galileo E1, Galileo E5a, Galileo E5b et Galileo E5 AltBOC pour Galileo) a été menée dans ce mémoire. Pour ce faire, une combinaison d’observations appelée double différence (DD) est utilisée sous différentes configurations (ligne de base nulle (ZB), courte (SB) et moyenne (MB)) de récepteurs GNSS. Les récepteurs utilisés appartiennent à l’Université de Liège (2 récepteurs Trimble NetR9, 1 récepteur Septentrio XS et un récepteur Septentrio X4). Il ressort de cette étude que Galileo E5 AltBOC présente les observations les plus précises (en ZB, toutes sources d’erreurs éliminées). L’analyse démontre également qu’une précision de l’ordre de quelques décimètres sur la position à déterminer peut être atteinte avec les codes transmis par le signal Galileo E5, et ce jusqu’à 25 kilomètres de distance. [less ▲]

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See detailSalon de la géomatique F.I.G. 2016 - Saint-Dié
Donnay, Jean-Paul ULg

Conference (2016, March 03)

Le Festival International de la Géographique (FIG) est organisé depuis 1990 à Saint-Dié-des-Vosges. Il accueille chaque année quelque 50.000 visiteurs et rassemble tant les spécialistes internationaux et ... [more ▼]

Le Festival International de la Géographique (FIG) est organisé depuis 1990 à Saint-Dié-des-Vosges. Il accueille chaque année quelque 50.000 visiteurs et rassemble tant les spécialistes internationaux et que les simples amateurs de culture et d’animation. Conférences, débats, tables rondes, cafés géographiques, expositions, foire du livre, salon de la géomatique, films… tout dans la ville et durant 3 jours est consacré – gratuitement – à la présentation des dernières découvertes de la recherche scientifique en géographie. Chaque année, un pays invité est à l’honneur. En 2016, c’est la Belgique ; de sorte que les chercheurs, les enseignants et les entreprises publiques et privées belges sont spécialement invités à participer à cette manifestation. La présentation faite durant la journée BeGeo du 3 mars à Bruxelles aura pour but de présenter les conditions de participation et d’inviter les partenaires belges au Salon de la Géomatique organisé durant le Festival International de la Géographie du 30 septembre au 2 octobre 2016. [less ▲]

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See detailMetamorphosing cultural patterns: Cassirer in the steps of Warburg on Culture Theory
Hagelstein, Maud ULg

Conference (2016, March 03)

My argument stems from a reading of the fifth study in Cassirer’s The Logic of the Cultural Sciences (1942), devoted to the “Tragedy of Culture.” I contend that this fifth study resolves an observable ... [more ▼]

My argument stems from a reading of the fifth study in Cassirer’s The Logic of the Cultural Sciences (1942), devoted to the “Tragedy of Culture.” I contend that this fifth study resolves an observable indecision in Cassirer’s position on cultural productions: to lead man toward greater happiness and freedom, should one strive to uphold traditional forms, or should one abandon old models and create new ones? I believe that Cassirer’s consideration of art historian Aby Warburg’s works (1866-1929) constitutes a defining moment in understanding his answer to that question. This fifth study illustrates the profound impact of Warburg’s model for understanding culture on Cassirer’s philosophy. Contrary to the claims of some exegetes, Cassirer and Warburg’s theoretical positions on the matter are very close. Cassirer’s treatment of the reception of artistic forms (he argues that form reception is never merely a passive act) follows, point by point, Warburg’s theory of the survival (Nachleben) of artistic motifs. [less ▲]

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See detailAnticoherence of spin states with point-group symmetries
Baguette, Dorian ULg; Damanet, François ULg; Giraud, Olivier et al

Poster (2016, March 02)

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana ... [more ▼]

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana represen- tation of spin states in terms of points on the unit sphere, we analyze the consequences of a point-group symmetry in their arrangement on the quantum properties of the corresponding state [1]. We focus on the identi cation of anticoherent states (for which all reduced density matrices in the symmetric subspace are maximally mixed) associated with point-group-symmetric sets of points. We provide three di erent characterizations of anticoherence and establish a link between point symmetries, anticoherence, and classes of states equivalent through stochastic local operations with classical communication. We then in- vestigate in detail the case of small numbers of qubits and construct in nite families of anticoherent states with point-group symmetry of their Majorana points, showing that anticoherent states do exist to arbitrary order. [1] D. Baguette et al., Phys. Rev. A 92, 052333 (2015). [less ▲]

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See detailReversal of Long-Term Trends in Ethane Identified from the Global Atmosphere Watch Reactive Gases Measurement Network
Helmig, Detlev; Buchmann, Brigitte; Carpenter, Lucy et al

Poster (2016, March 02)

Reactive gases play an important role in climate and air pollution issues. They control the self-cleansing capability of the troposphere, contribute to air pollution and acid deposition, regulate the ... [more ▼]

Reactive gases play an important role in climate and air pollution issues. They control the self-cleansing capability of the troposphere, contribute to air pollution and acid deposition, regulate the lifetimes and provide tracers for deciphering sources and sinks for greenhouse gases. Within GAW, the focus is placed on long-term, high-quality observations of ozone (O3), carbon monoxide (CO), volatile organic compounds (VOC), nitrogen oxides (NOx), and sulfur dioxide (SO2). More than 100 stations worldwide carry out reactive gases measurements with data reported to two World Data Centers. The reactive gases program in GAW cooperates The WMO GAW Reactive Gases Program with regional networks and other global monitoring initiatives in order to attain a complete picture of the tropospheric chemical composition. Observations are being made by in-situ monitoring, measurements from commercial routine air-crafts (e.g. IAGOS), column observations, and from flask sampling networks. Quality control and coordination of measurements between participating stations are a primary emphasis. GAW reactive gases data in rapid delivery mode are used to evaluate operational atmospheric composition forecasts in the EU Copernicus Atmospheric Monitoring Service. Oversight of the program is provided by GAW-WMO coordinated Reactive Gases Scientific Advisory Committee (RG-SAG). [less ▲]

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See detailLe manuel : pourquoi ? comment ?
Pochet, Bernard ULg

Conference (2016, March 01)

The aim of this communication is to present the objective the tools used to perform, meet objectives and overcome technical constraints

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See detailEvaluer les connaissances et savoir-faire en matière de recherche d’informations scientifiques : comment faire avec de grands groupes d’étudiants en bachelier ?
Vandenput, Sandrina ULg; Crahay, Vinciane ULg; Piazza, Aurélie ULg et al

Conference (2016, March 01)

Au terme du cours consacré à la recherche d’informations scientifiques - au programme des bacheliers de la Faculté de Médecine vétérinaire et de la Faculté de Psychologie, Logopédie et des Sciences de ... [more ▼]

Au terme du cours consacré à la recherche d’informations scientifiques - au programme des bacheliers de la Faculté de Médecine vétérinaire et de la Faculté de Psychologie, Logopédie et des Sciences de l’Éducation (Université de Liège) - les étudiants doivent avoir une vue d’ensemble de la publication scientifique et être capables de (i) mener de manière autonome une recherche d’informations et (ii) de citer correctement leurs sources en respectant des normes bien précises lors de la rédaction de documents. L’évaluation de ce cours est contraignante car il s’agit de cohortes d’étudiants de plus en plus grandes (> 300 étudiants par cursus). Comment évaluer les connaissances ainsi que les savoir-faire de grands groupes d’étudiants ? Jusqu’alors l’examen se composait de questions ouvertes et nécessitait que chaque étudiant ait à sa disposition un ordinateur connecté à Internet. Cette méthode requérait une logistique importante avant et pendant l’examen ainsi que des semaines de correction. Plusieurs alternatives à cette évaluation ont alors été envisagées : travail individuel, travail de groupe, questionnaire à choix multiple… mais elles ne répondaient pas aux exigences fixées par les compétences à évaluer. La piste retenue pour cette nouvelle année académique reste contraignante du point de vue organisationnel (ordinateur pour chaque étudiant) mais permet une correction standardisée, automatisée, fiable et rapide. En effet, le questionnaire combine désormais des questions à choix multiple (QCM ; jusqu’à 9 propositions de réponses) et des questions à choix large (QCL ; jusqu’à 999 propositions). Le QCL présente l’avantage d’être proche de l’évaluation à l’aide de questions ouvertes sans les désavantages de la correction. Nous proposons de présenter ce dispositif évaluatif ainsi que ses avantages et inconvénients par rapport à d’autres méthodes d’évaluation. [less ▲]

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See detailClassifying simulated wheat yield responses to changes in temperature and precipitation across a european transect
Fronzek, S.; Pirttioja, N.; Carter, T. R. et al

Conference (2016, March)

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Peer Reviewed
See detailDevelopment of a translation stage for in situ non-invasive analysis and high resolution imaging
Strivay, David ULg; Clar, Mathieu ULg; Rakkaa, Saïd ULg et al

Poster (2016, March)

Non-invasive imaging techniques and analytical instrumentation for cultural heritage object studies have undergone a tremendous development over the last years. Many new miniature and/or handheld systems ... [more ▼]

Non-invasive imaging techniques and analytical instrumentation for cultural heritage object studies have undergone a tremendous development over the last years. Many new miniature and/or handheld systems have been developed and optimized. Nonetheless, these instruments are usually used with a tripod or a manual position system. This is very time consuming when performing point analysis or 2D scanning of a surface. The Centre Européen d’Archéométrie (CEA) has build a translation system made of pluggable rails of 1 m long with a maximum length and height of 3 m. Three motors embedded in the system allow the platform to be moved along these axis, toward and backward from the sample. The rails hold a displacement system, providing a continuous movement. Any position can be reached with a reproducibility of 0.1 mm. The displacements are controlled by an Ethernet connection through a laptop computer running a multiplatform homemade software written in JAVA. This software allows a complete control over the positioning using a simple, unique, and concise interface. Automatic scanning can be performed over a large surface of 3 meters on 3 meters. The Ethernet wires provide also the power for the different motors and, if necessary the detection head. The platform has been originally designed for a XRF detection head (with its full power alimentation) but now can accommodate many different systems like IR reflectography, digital camera, hyperspectral camera, Raman probes, etc. The positioning system can be modified to combine the acquisition software of the imaging or analytical techniques and the positioning software. [less ▲]

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See detailNovel composite heterozygous mutation of the receptor for hCG and LH leading to male disorder of sexual development
Potorac, Iulia ULg; FUDVOYE, Julie ULg; GAILLEZ, Stephanie ULg et al

in Abstract book - 17th World Congress of Gynecological Endocrinology (2016, March)

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See detailBois, brique et fer : Approche multi-disciplinaire de la charpente de l'église Notre-Dame du Sablon, Bruxelles (RBC)
CREMER, Sarah; FRAITURE, Pascale; Hoffsummer, Patrick ULg et al

in Archaeologia Mediaevalis (2016, March), 39

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See detailEstetrols’ Potential for Neuroprotection Following the injury to the Developing Brain: Preclinical Studies
Tskitishvili, Ekaterine ULg; Nisolle, Michelle ULg; Noël, Agnès ULg et al

in The 17th World Congress of Gynecological Endocrinology, Florence 2-5 March 2016 (2016, March)

Context: Hypoxic-Ischemic encephalopathy (HIE) remains a major cause of perinatal brain injury. The brain rapidly increases in size, shape and complexity during the second and third trimesters. A sentinel ... [more ▼]

Context: Hypoxic-Ischemic encephalopathy (HIE) remains a major cause of perinatal brain injury. The brain rapidly increases in size, shape and complexity during the second and third trimesters. A sentinel event in late pregnancy or the intrapartum period may have an acute profound effect on a previously neurologically intact fetus, leading to the development of (HIE). The nature of the deficits is dependent on the gestational age and severity of the insult, though it is seldom reported in preterm infants. Studies in animal models of HIE may provide important information for the development of treatment for this pathological condition. Estetrol (E4) is a recently described estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. Objective: In this study, we evaluated E4’s neuroprotective and therapeutic potency in neonatal (in vivo) HIE model of the immature 7-day-old newborn rat. Methods: Rat pups body temperatures were examined along with their body and brain weights. Brains were studied at the level of the hippocampus and cortex. Intact cell counting and expressions of markers for neuronal early grey matter damage (microtubule-associated protein-2 (MAP-2)), neurogenesis (doublecortin (DCX)) and angiogenesis (vascular-endothelial growth factor (VEGF)) were evaluated by histo- and immunohistochemistry. The serum levels of two markers of brain damage (S100B and glial fibrillary acidic protein (GFAP)) were measured by ELISA. Results: Our results demonstrate that E4 has a significant neuroprotective and therapeutic effects. Estetrol decreases the early gray matter loss, and promotes neuro- and angiogenesis in vivo. Estetrol treatment has no effects on body weight, brain weight or body temperature. Conclusion: Taken together, E4 might become an important safe and physiological substance to treat neonatal HIE. [less ▲]

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See detailDynamical thermalization in Bose-Hubbard systems
Schlagheck, Peter ULg; Shepelyansky, Dima L.

Conference (2016, March)

A bosonic many-body system can exhibit the Bose-Einstein distribution in its single-particle eigenstates not only if it is coupled to a heat and particle reservoir, but also if it is subject to a two-body ... [more ▼]

A bosonic many-body system can exhibit the Bose-Einstein distribution in its single-particle eigenstates not only if it is coupled to a heat and particle reservoir, but also if it is subject to a two-body interaction of moderately low strength which couples the single-particle eigenstates with each other. We numerically verify this dynamical thermalization conjecture within disordered Bose-Hubbard rings of finite size whose parameters are chosen such that the dynamics of the system can be expected to be ergodic [1]. This allows one to associate with each many-body eigenstate of the Bose-Hubbard system well-defined (positive or negative) values for the effective temperature and the effective chemical potential which depend on the energy per particle of the eigenstate under consideration [1]. With this information one can then predict the populations of single-particle eigenmodes within each many-body eigenstate of the system according to the Bose-Einstein distribution, without knowing more details about the quantum dynamics of the many-body system. [less ▲]

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See detailReturn words and factor complexity
Leroy, Julien ULg

Conference (2016, March)

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Peer Reviewed
See detailMobiliser la culture du pays d’origine, un défi pour l’intégration des migrants?
Mescoli, Elsa ULg; Gsir, Sonia ULg

Conference (2016, March)

La culture constitue pour les migrants et leurs pays d’origine un moyen de maintenir des liens réciproques après la migration. Mais quels sont les enjeux de la mobilisation de la culture d’origine pour ... [more ▼]

La culture constitue pour les migrants et leurs pays d’origine un moyen de maintenir des liens réciproques après la migration. Mais quels sont les enjeux de la mobilisation de la culture d’origine pour l’intégration des migrants dans leurs nouveaux pays de résidence ? Cette présentation analyse le déploiement de la culture du pays d’origine à trois niveaux : celui des pratiques quotidiennes des migrants, des politiques d’intégration et de diaspora et enfin, le niveau des associations, en particulier les centres culturels établis en Europe par les pays d’origine des migrants. Les pratiques culturelles des migrants et les actions et institutions culturelles mises en place par les pays d’origine sont confrontées au cadre légal européen en matière de diversité culturelle mais aussi aux politiques et discours sur l’intégration des migrants. La perspective à la fois anthropologique et sociologique adoptée révèle les processus de domination culturelle qui sont à l’œuvre. Elle permet aussi de questionner l’idée d’identité culturelle en montrant le dynamisme qui caractérise les cultures mais aussi la créativité des communautés locales dans un environnement globalisé. Finalement, on constate qu’une variété de facteurs est en jeu dans les processus d’intégration des migrants, que les dynamiques de la culture elle-même déterminent des appartenances multiples et aussi que les identités se développent au sein des interactions entre cultures. Si on ne peut établir de lien causal et univoque entre les pratiques culturelles liées au pays d’origine et l’intégration des migrants dans le pays de résidence, on peut par contre se référer à la notion d’ethnicité et à sa fonction politique (Comaroff et Comaroff, 2009). [less ▲]

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See detailThe bottom up innovation and entrepreneurship in smart cities, case of Indian cities
Kummitha, Rama; Crutzen, Nathalie ULg

Conference (2016, March)

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See detailInfection expérimentale de porcs, par voie intraveineuse ou orale, avec une souche du virus de l’hépatite E (HEV) de sanglier, une souche de HEV porcine et une souche de HEV de sanglier préalablement passée en modèle porcin
Thiry, Damien ULg; Rose, Nicolas; Mauroy, Axel ULg et al

Poster (2016, March)

La transmission zoonotique du HEV est particulièrement mise en cause dans les pays développés dans lesquels la transmission via les eaux usées est beaucoup moins fréquente que dans les pays en voie de ... [more ▼]

La transmission zoonotique du HEV est particulièrement mise en cause dans les pays développés dans lesquels la transmission via les eaux usées est beaucoup moins fréquente que dans les pays en voie de développement. Des séroprévalences élevées sont observées chez certaines espèces animales dans plusieurs pays européens. Cette étude a porté sur la transmission potentielle au porc d\'une souche de HEV provenant du sanglier (WbHEV) par inoculation intraveineuse ou par voie orale et sur l’étude des conséquences de l’infection du porc par une souche de WbHEV, une souche de WbHEV précédemment passée chez le porc et une souche porcine de HEV après inoculation orale. Tout d\'abord, une infection par voie intraveineuse a été réalisée au cours de laquelle cinq porcelets ont été répartis en deux groupes. Le premier était constitué de trois porcs inoculés avec du WbHEV et le second, de deux porcs inoculés avec un foie de porc négatif envers le HEV. Tous les porcs ont été euthanasiés et autopsiés 8, 9 et 10 jours après l’inoculation. Cette première expérience avait pour objectif d’obtenir suffisamment de virus en vue de réaliser les inoculations par voie orale. Elle a également permis d’étudier l’infectivité d’une souche de HEV-3 provenant du sanglier chez le porc. Ensuite, une infection par voie orale a été réalisée sur 12 porcelets répartis en 4 groupes inoculés respectivement avec une souche de WbHEV, une souche de WbHEV précédemment passée chez le porc, une souche porcine de HEV et un foie de porc HEV négatif. Cette expérience a duré 56 jours. Les échantillons récoltés ont ensuite été analysés par qRT-PCR, ELISA, Western blot et histopathologie. Le nombre de porcs virémiques était plus faible après infection orale qu’après inoculation intraveineuse. Ce résultat contraste avec la présence du HEV dans les matières fécales des porcs au cours des deux expériences. Les résultats montrent également une propagation du virus dans différents organes après inoculation intraveineuse, mais pas après inoculation par voie orale. Cette étude fournit la première preuve expérimentale de la propagation précoce du virus dans l\'organisme après infection intraveineuse avec une souche de HEV provenant du sanglier et montre qu’une telle souche pourrait être naturellement transmise entre les sangliers et les porcs, mais aussi entre porcs et donc survivre dans la population porcine. [less ▲]

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See detailCarbon dioxide and vegetable oil for the synthesis of bio-based polymer precursors, theoretical study of the organocatalyzed synthesis of non-isocyanate polyurethanes
Alves, Margot ULg; Jérôme, Christine ULg; Tassaing, Thierry

Conference (2016, March)

Non-isocyanate polyurethanes (NIPUs) represent a green alternative to the classical synthesis route of polyurethanes involving toxic isocyanates. This “greener” approach based upon renewable feedstocks ... [more ▼]

Non-isocyanate polyurethanes (NIPUs) represent a green alternative to the classical synthesis route of polyurethanes involving toxic isocyanates. This “greener” approach based upon renewable feedstocks and carbon dioxide consists in a two-step reaction. In a first step, carbonated vegetable oils are obtained using an appropriate catalyst by the chemical fixation of CO2 onto vegetable oils formerly epoxidized. Finally, the ring-opening polymerization (ROP) of the carbonated vegetable oil by a diamine provides hydroxy urethanes. In this las step, some organocatalysts have been recently proposed that allows achieving good conversion rates in particular in the case of aromatic diamines. However, the activation mechanism of these organocatalysts is not fully elucidated. In this context, the aim of the present project relies on the theoretical study of a model reaction using DFT calculations. Bicyclic guanidine based catalysts, 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and 7-methyl-TBD (MTBD), were investigated as catalysts for the reaction between propylene carbonate and aliphatic or aromatic amines. The structural ability of TBD to simultaneously give and receive protons was highlighted by the detailed mechanism investigation. The bifunctional activity of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

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See detailBad News in Service Encounters: Ideas and Insights
Delcourt, Cécile ULg; Gremler, Dwayne

Conference (2016, March)

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See detailLe sensible chez Franz Brentano
Gauvry, Charlotte ULg

Conference (2016, March)

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See detailOrphan Black and Literature
Guesse, Carole ULg

Conference (2016, March)

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See detailImproving laboratory diagnostic efficiency of epizootic diseases in Belgium
Cargnel, Mickaël ULg; Roelandt, Sophie; Van der Stede, Yves et al

Poster (2016, March)

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See detailAntihyperglycémiants, antihypertenseurs et hypolipidémiants : comparaison des effets sur la mortalité et la morbidité cardiovasculaire chez le patient diabétique de type 2
SCHEEN, André ULg

Poster (2016, March)

Introduction : Réduire le risque de mortalité et morbidité cardiovasculaire (CV) chez le patient diabétique de type 2 (DT2) est primordial, mais les effets protecteurs semblent différents selon le mode ... [more ▼]

Introduction : Réduire le risque de mortalité et morbidité cardiovasculaire (CV) chez le patient diabétique de type 2 (DT2) est primordial, mais les effets protecteurs semblent différents selon le mode d’intervention pharmacologique étudié. Patients et méthodes : Les données de mortalité (totale et CV) et morbidité (infarctus du myocarde ou IDM, accidents vasculaires cérébraux ou AVC) rapportées (réduction du risque relatif) dans les essais ayant testé un traitement anti-hyperglycémiant sont comparées avec les résultats publiés dans deux méta-analyses concernant les hypolipidémiants et les anti-hypertenseurs consacrées au DT2. Résultats : Les antihypertenseurs réduisent les IDM (-12%) et la mortalité globale (-13%) de façon comparable, et diminuent davantage les AVC (-27%). Les hypolipidémiants diminuent davantage les IDM (- 22%) et les AVC (-21%) que la mortalité globale (-9%) (ou la mortalité CV : - 13%). Les données concernant les antihyperglycémiants diffèrent considérablement selon les médications testées. L’insuline et les sulfamides (UKPDS) réduisent plus les IDM (- 21%) que la mortalité totale (-8%), mais augmentent les AVC (+ 14%). La metformine (UKPDS) réduit, de façon comparable, les IDM (-39%), les AVC (-41%) et la mortalité totale (-36%). La pioglitazone (PROactive) diminue davantage les IDM (-17%) et les AVC (-19%) que la mortalité (-4%). Les gliptines (combinaison de SAVOR TIMI 53, EXAMINE, TECOS) ont montré des effets globalement neutres sur la mortalité totale (0%), les IDM (-2%) et les AVC (-1%). L’empagliflozine (EMPA-REG OUTCOME) se singularise par un effet favorable nettement plus marqué sur la mortalité totale (-32 %) et CV (- 38%) que sur les IDM (-13%) ou les AVC (+18%). Conclusion : Les discordances observées suggèrent l’implication de mécanismes protecteurs différents selon les interventions testées. EMPA-REG OUTCOME, le seul essai démontrant un effet plus marqué sur la mortalité que sur les événements CV, suggère un mécanisme propre de l’inhibiteur des SGLT2. [less ▲]

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Peer Reviewed
See detail“Color is a kind of holy substance for me”: analytical study of the Sam Francis’ palette from the 1940’s to the 1990’s
Defeyt, Catherine ULg; Mazurek, Joy; Zebala, Aneta et al

Poster (2016, March)

The Sam Francis’s colors, literally described as vivid, saturated, pure, vibrant intense and rich, largely contribute to the unique character of his work. This idiosyncrasy explains the interest in ... [more ▼]

The Sam Francis’s colors, literally described as vivid, saturated, pure, vibrant intense and rich, largely contribute to the unique character of his work. This idiosyncrasy explains the interest in conducting an extended study on the Francis’ painting materials through analytical techniques. On the other hand, many Francis’ paintings display colored surfaces that exhibit bronzing, fluorescent or opalescent effects. As a consequence, retouching paint losses from Sam Francis works may become a challenging task for the involved conservators, the degree of the color matching required in the imitative technique being particularly difficult to attain, in the presence of such surfaces. Furthermore, the attained degree of the color match has to be conserved in all conditions of illumination and observation. The use of pigments chemically similar to the original ones is often necessary for matching highly chromatic pigments. Though, many modern synthetic organic pigments (SOPs) possess high color strength. That is why the characterization of the Francis palette would provide helpful information to the conservators, which have to deal with this type of issue. The upcoming Getty publication Sam Francis: The Artist’s Materials, planned for 2016, offered the opportunity for in-depth analyses of hundreds paint samples. Almost three hundreds of paint fragments supplied by the Sam Francis Foundation have been investigated at the GCI laboratory, by using three complementary analytical techniques, Py-GC-MS, Raman and FTIR spectroscopies. The Raman spectroscopy is one of the most efficient techniques for identifying SOPs in paint systems, while the Py-GC-MS and FTIR methods provide essential information concerning the binding media. The analyzed paint fragments were sampled from twenty-nine canvases and works on paper, made between 1946 and 1992. Although, primary established in Southern California, Sam Francis spent numerous long journeys in different places around the world, including Paris, Bern, Mexico City, New York and Tokyo. However, the material study has outlined the uninterrupted use of` certain classes of SOPs in specific colors. For example, copper phthalocyanine (CuPc) pigments were systematically detected in the blue and green samples, while azo pigments have been identified in most of the yellow areas sampled from post 1940s works. Regardless of the support and the paint technique, the Francis’ blues primary contain Ultramarine and/or CuPc blue pigments. And, it has been shown that the bronzing blue surfaces noticed for some of the investigated artworks correspond to PB15-based paint films. The present study has also underlined the recurrent use of perinone orange and dioxazine violet in fluorescent orange and purple area. Despite the early introduction of SOPs, on the Francis’ palette, the works dating from the 1940’s remained mainly composed of traditional inorganic pigments, for instance lead white and red, chrome yellow, viridian and iron oxides. Interestingly, various binding media, i.e. Shellac gum, modified and unmodified oils, PVA, alkyd resins and acrylic copolymers have been identified. Actually, the investigated samples have pointed out the frequent combination of more than three types of binders on a same painting. Through the identification of the various SOPs used by Francis over fifty years, this research provide helpful information for selecting the most appropriate retouching pigments. [less ▲]

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See detailAzacytidine Enhances Regulatory T-Cells In Vivo and Prevents Experimental Xenogeneic Graft-Versus-Host Disease
Ehx, Grégory ULg; Fransolet, Gilles ULg; de Leval, Laurence ULg et al

in Biology of Blood and Marrow Transplantation (2016, March), 22(3), 393

Background. The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 ... [more ▼]

Background. The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Tregs). Objective. We investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) in a humanized murine model of transplantation, and described the impact of the drug on human T cells in vivo. Methods. In order to induce xGVHD, human peripheral blood mononuclear cells (huPBMC) were administered intravenously in NOD-scid IL-2Rγnull (NSG) mice. Results. AZA successfully improved both survival (p<0.0001) and xGVHD scores (p<0.0001). Further, AZA significantly decreased human T-cell proliferation as well as INF-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA administration significantly increased the function, proliferation and frequency of Tregs through demethylation of FOXP3i1 and higher secretion of IL-2 by conventional T cells due to IL2 gene promoter site 1 demethylation. Interestingly, among AZA-treated mice surviving the acute phase of xGVHD, there was an inverse correlation between the presence of Tregs and signs of chronic GVHD. Finally, Tregs harvested from the spleen of AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Conclusion. These findings emphasize a potential role for AZA as prevention or treatment of GVHD and other autoimmune diseases. [less ▲]

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See detailAn ensemble of projections of wheat adaptation to climate change in europe analyzed with impact response surfaces
Ruiz-Ramos, M.; Ferrise, R.; Rodríguez, A. et al

Conference (2016, March)

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See detailA "external" StandPoint on QMS
Massart, Sébastien ULg

Conference (2016, March)

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See detailRelations entre neuropathie autonome cardiaque (NAC), pression pulsée (PP) et insuffisance rénale chronique (IRC) chez le patient diabétique de type 2 (DT2)
PHILIPS, Jean-Christophe ULg; MARCHAND, Monique ULg; SCHEEN, André ULg

Poster (2016, March)

Objectifs : Ce travail étudie les relations entre trois complications diabétiques, la NAC, l’élévation de PP (marqueur de rigidité artérielle) et la diminution du débit de filtration glomérulaire (DFG ... [more ▼]

Objectifs : Ce travail étudie les relations entre trois complications diabétiques, la NAC, l’élévation de PP (marqueur de rigidité artérielle) et la diminution du débit de filtration glomérulaire (DFG) chez le patient DT2. Patients et méthodes : L’étude comprend 79 patients DT2 (53H/26F; 56±8 années; 11±8 années de DT2; IMC 28,4±4,6 kg/m²) analysés par enregistrement continu de la pression artérielle (PA) et de la fréquence cardiaque (appareil Finapres) lors d’un test postural standardisé. Le gain baro-réflexe (GBR, indice de NAC) correspond à la pente de la relation entre les espaces R-R et PA systolique (PAS) lors du redressement accroupi-debout. PP est analysée pendant tout le test et par son augmentation durant l’accroupissement (delta PP). DFG est estimé par la formule MDRD au début puis après un suivi moyen de 12±5 ans. Résultats : Les valeurs initiales sont : HbA1c : 8,8± 1,7%; DFG : 86±25 ml/min ; PP : 62±10 mmHg; BRG : 1,8±1,4 msec/mmHg. DFG est inversement corrélé à l’âge (r=-0,317; p=0,020), très positivement corrélé avec GBR (r=0,453; p=0,008), sans corrélation significative avec HbA1c (r=-0,023; p=0,935) ni avec PAS, PP ou encore delta PP (r=-0,206; p=0,114; NS). La diminution de DFG (-12±23 ml/min) lors du suivi de 12 ans n’a pu être corrélée de façon significative aux valeurs initiales et finales d’HbA1c, ni aux valeurs initiales de GBR (et d’autres marqueurs de NAC) ou de PA, même si la relation est proche de la signification pour delta PP (r=0,20; p=0,060). Conclusion : La forte relation initiale entre DFG et GBR suggère que IRC et NAC sont aggravées de façon conjointe et, possiblement, qu’une des deux complications influence l’autre. L’absence de toute corrélation entre la chute ultérieure de DFG et les autres paramètres initiaux peut s’expliquer par l’origine multifactorielle de la progression de l’IRC chez le patient DT2. [less ▲]

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See detailDes pratiques enseignantes qui font obstacle au rôle des modèles dans la construction des savoirs scientifiques
Dontaine, Matthieu; Heins, Pascal ULg; Hindryckx, Marie-Noëlle ULg et al

Conference (2016, March)

Dans une perspective comparatiste, des didacticiens de plusieurs disciplines (biologie, chimie, histoire de l’art, mathématique et physique) ont étudié des pratiques enseignantes faisant obstacle au rôle ... [more ▼]

Dans une perspective comparatiste, des didacticiens de plusieurs disciplines (biologie, chimie, histoire de l’art, mathématique et physique) ont étudié des pratiques enseignantes faisant obstacle au rôle des modèles dans la construction des savoirs scientifiques. Leur réflexion croisée les a amenés à considérer des niveaux élevés de l’échelle de codétermination didactique de Chevallard (2012) pour identifier des indicateurs d’une certaine forme de positivisme empirique dans l’épistémologie spontanée des enseignants. Cette posture s’exprime plus ou moins différemment d’une discipline à l’autre mais le fait que les modèles et théories enseignées ont fait ou non l’objet d’une standardisation au sein de communautés scientifiques savantes déterminent fortement leur transposition didactique. De ce point de vue, l’exemple de l’histoire de l’art a joué un rôle méthodologique important permettant de contraster et de questionner les pratiques dans les autres disciplines. Ce questionnement s’inscrit dans un objectif à plus long terme qui est la reproblématisation (au sens de Orange, 2005) d’enseignements relatifs aux disciplines enseignées. [less ▲]

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See detailA novel protocol for the design of artificial (β/α)8-barrel proteins
Martina, Cristina ULg; Figueroa Yévenes, Maximiliano ULg; Combs, Steven et al

Poster (2016, March)

Designing de novo proteins of more than 100 amino acids is still challenging. The creation of artificial (β/α)8-barrel proteins had only one successful example in literature, thank to use of internal ... [more ▼]

Designing de novo proteins of more than 100 amino acids is still challenging. The creation of artificial (β/α)8-barrel proteins had only one successful example in literature, thank to use of internal spatial symmetry. Here we present a protocol to design de novo (β/α)8-barrel proteins without symmetry restriction. First, the backbone was created in 4 steps: (I) Rosetta ParametricDesign produced an highly symmetric polyalanine scaffold with no loops; (II) Rosetta Fixed-Backbone Design used the previous output to substitute the alanines in all the position; (III) Loops were constructed with Modeller joining the terminus of the secondary structure elements and (IV) RosettaRelax performed relaxation, creating around 4000 different models. 28 backbone models were selected for the next steps of sequence design. To design the final proteins for experimental validation, 10 cycles of Rosetta Design and Relax were performed. In the first cycle only apolar amino acids were allowed in hydrophobic regions; in the next 6 cycles, amino acids were allowed based on the definition of 3 regions: core, boundaries and surface. All the amino acids were allowed in each position in the last 3 cycles. More than 10000 different sequences were created and analyzed in term of amino acid composition, sequence similarity with natural protein, secondary structure prediction, and molecular dynamics simulations. The 30 best candidate sequences have been selected for experimental verification. [less ▲]

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See detailNewborn screening for sickle cell disease : 13 years at the CHR "La Citadelle", Liège
Sepulchre, Edith; Ketelslegers, Olivier; Minon, Jean-Marc et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2016, March), 18(1), 107

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See detailTheoretical study of the organocatalyzed synthesis of NIPUs
Alves, Margot ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

Poster (2016, March)

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See detailCertificat successoral européen Aperçu et mise en oeuvre
Wautelet, Patrick ULg

Conference (2016, March)

Cette présentation a pour objectif de donner un aperçu général du fonctionnement du certificat successoral européen mis en place par le Règlement successions

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See detailDouble genetic defect in a case of congenital hypogonadotropic hypogonadism
Potorac, Iulia ULg; Pintiaux, Axelle ULg; VALDES SOCIN, Hernan Gonzalo ULg et al

in Abstract book - 17th World Congress of Gynecological Endocrinology (2016, March)

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See detailDes pratiques enseignantes qui font obstacle au rôle des modèles dans la construction des savoirs scientifiques. 2. Le cas de la discipline scolaire "histoire de l'art"
Heins, Pascal ULg

Conference (2016, March)

Dans une perspective comparatiste, des didacticiens de plusieurs disciplines (mathématiques, physique, chimie, biologie, histoire de l’art) ont étudié des pratiques enseignantes faisant obstacle au rôle ... [more ▼]

Dans une perspective comparatiste, des didacticiens de plusieurs disciplines (mathématiques, physique, chimie, biologie, histoire de l’art) ont étudié des pratiques enseignantes faisant obstacle au rôle des modèles dans la construction des savoirs scientifiques. Leur réflexion croisée les a amenés à considérer des niveaux élevés de l’échelle de co-détermination didactique de Chevallard (2012) pour identifier des indicateurs d’une certaine forme de positivisme empirique dans l’épistémologie spontanée des enseignants. Cette posture s’exprime plus ou moins différemment d’une discipline à l’autre, mais le fait que les modèles et théories enseignées ont fait ou non l’objet d’une standardisation au sein de communautés scientifiques savantes déterminent fortement leur transposition didactique. De ce point de vue, l’exemple de l’histoire de l’art a joué un rôle méthodologique important permettant de contraster et de questionner les pratiques dans les autres disciplines. Ce questionnement s’inscrit dans un objectif à plus long terme qui est la reproblématisation (au sens de Orange, 2005) d’enseignements relatifs aux disciplines enseignées. [less ▲]

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See detailGalectin-1 is involved in osteoclast biology
Muller, Joséphine ULg; Binsfeld, Marilène ULg; DUBOIS, Sophie ULg et al

Poster (2016, February 28)

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See detailEDUCATION RACHIDIENNE : DE L’ENFANT AU SPORTIF DE HAUT NIVEAU
Vanderthommen, Marc ULg; GROSDENT, Stéphanie ULg; Fettweis, Tatiana ULg et al

in Livre des Résumés du 2ème Colloque Guy Namurois (2016, February 27)

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See detailSPÉCIALISATION SPORTIVE PRÉCOCE : QUEL IMPACT SUR LA PERFORMANCE, SUR LE DÉVELOPPEMENT ET SUR LA SANTÉ ET QUELLES PISTES DE SOLUTION ?
Jidovtseff, Boris ULg

in Jidovtseff; Halleux, Philippe; Lambert, Eric (Eds.) Livre des résumés du 2ème colloque Guuy Namurois (de l'éducation physique à la performance sportive) (2016, February 27)

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See detailIntérêt d’un modèle de compétition adapté aux enfants en athlétisme : le Kid’s Athletics
Jidovtseff, Boris ULg; Wuillaume, Sandrine; Cloes, Marc ULg

Poster (2016, February 27)

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See detailL’ACCOUTUMANCE À L’EAU, UN PASSAGE OBLIGÉ AVANT LA NATATION ?
Mornard, Manhattan ULg; Delvaux, Anne ULg; Delsupexhe, Nadège et al

Poster (2016, February 27)

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See detailUn manuscrit de l’entourage de Noël Bellemare sous le microscope : analyse du ms. W 29 de l’Université de Liège
Oger, Cécile ULg; L'Estrange, Elizabeth; Gilbert, Bernard ULg et al

Conference (2016, February 26)

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See detailAnnual dynamics of pCO2 within bulk sea ice and related CO2 fluxes at Cape Evans (Antarctica)
Van Der Linden, Fanny ULg; Champenois, Willy ULg; Heinesch, Bernard ULg et al

Poster (2016, February 26)

Sea ice is a biome actively participating in the regional cycling of CO2 as both a source and a sink at different times of the year. In the frame of the YROSIAE project (Year-Round Ocean-Sea-Ice ... [more ▼]

Sea ice is a biome actively participating in the regional cycling of CO2 as both a source and a sink at different times of the year. In the frame of the YROSIAE project (Year-Round Ocean-Sea-Ice-Atmosphere Exchanges), annual dynamics of sea ice pCO2 was compared with CO2 fluxes measured by automated accumulation chambers at Cape Evans (Ross Island, Antarctica). Results confirmed a general trend of brine pCO2 supersaturation with respect to the atmosphere during the late winter (concentration of dissolved inorganic carbon - DIC - in brine and brine expulsion in the brine skim) leading to CO2 degassing, and undersaturation during the spring (carbon-uptake by autotrophs and brine dilution) leading to atmospheric CO2 uptake. Despite high primary production at the bottom of the ice in spring, DIC profiles suggest that sea ice as a whole appears to be net heterotrophic. Still, sea ice absorbs CO2 from the atmosphere, as a result of physical processes. Some variability in the CO2 fluxes (both in magnitude and sign) could not be explained by variability in sea ice pCO2 but rather seemed driven by variability in atmospheric conditions and sea ice surface properties. For instance, in late spring, CO2 fluxes showed a diurnal variability (from CO2 degassing to uptake) related to atmospheric temperature variations. Large and episodic CO2 fluxes were systematically positively correlated with strong wind events, and large CO2 degassing was observed over thin, wet and salty snow cover. [less ▲]

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See detailNitrous oxide dynamics in sea ice
Kotovitch, Marie ULg; Fripiat, François ULg; Moreau, Sébastien et al

Conference (2016, February 26)

Fluctuations in greenhouse gases (GHGs) concentration alter the energetic budget of the climate system. There is high confidence that natural systems related to snow, ice and frozen ground (including ... [more ▼]

Fluctuations in greenhouse gases (GHGs) concentration alter the energetic budget of the climate system. There is high confidence that natural systems related to snow, ice and frozen ground (including permafrost) are affected. Nitrous oxide (N2O) is one of the potent GHG naturally present in the atmosphere, but witch has seen his concentration growing since industrial era. N2O has a lifetime in the atmosphere of 114 years and a global warming potential (GWP) of 298 to be compared to carbon dioxide that has a GWP of 1. N2O is also describe as the dominant ozone-depleting substance emitted in the 21st Century. Yet, there are still large uncertainties and gaps in the understanding of the cycle of this compound through the ocean and particularly in sea ice. Sources and sinks of N2O are therefore still poorly quantified. The main processes (with the exception of transport processes) involved in the N2O cycle within the aquatic environment are nitrification and denitrification. To date, only one study by Randall et al. present N2O measurements in sea ice. Randall et al. pointed out that sea ice formation and melt has the potential to generate sea-air or air-sea fluxes of N2O, respectively. [less ▲]

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See detailL’enseignement de l’éducation physique en Belgique francophone : une lente transition vers la littératie physique et un ancrage sociétal
Cloes, Marc ULg

Conference (2016, February 25)

A la fin des années 90’, les autorités en charge de l’Education dans l’actuelle Fédération Wallonie-Bruxelles ont attribué à l’éducation physique la mission de développer trois domaines de compétences ... [more ▼]

A la fin des années 90’, les autorités en charge de l’Education dans l’actuelle Fédération Wallonie-Bruxelles ont attribué à l’éducation physique la mission de développer trois domaines de compétences (condition physique, habiletés gestuelles, coopération socio-motrice) pour poursuivre en parallèle quatre finalités (santé, sécurité, expression-communication, éducation sportive). Si les textes officiels semblaient encourager le développement d’un cours d’éducation physique où le sport cédait un peu de terrain à l’activité physique au sens large, force est de constater que, dans les faits, les séances sont restées essentiellement construites par rapport à la pratique de disciplines sportives (dont le choix tend par ailleurs à s’élargir et à se diversifier). Depuis quelques années, sous l’impulsion des formateurs d’enseignants, on constate toutefois une modification très progressive des mentalités. De plus en plus d’initiatives sont ainsi mises en place sur le terrain dans la perspective d’amener les élèves à devenir des citoyens responsables … de leur corps tout au long de leur vie. Cette évolution en faveur de la littératie physique s’accompagne par ailleurs de démarches visant à souligner l’ancrage sociétal de la discipline dont l’apport concret doit impérativement être mis en exergue : le cours d’éducation physique qui présente des liens directs avec ce qui se passe en dehors des murs de l’école. Le professeur d’éducation physique est ainsi de plus en plus présenté comme le potentiel coordinateur de la promotion d’un style de vie actif au sein des établissements scolaires. [less ▲]

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See detailDes modèles héroïques et bibliques pour François Ier. Le cas d’Hercule
Laruelle, Anne-Sophie ULg

Conference (2016, February 25)

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See detail4. La fumure azotée
Meza Morales, Walter ULg; Monfort, Bruno; Dumont, Benjamin ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2016, February 24)

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See detail10.1. L'intérêt de la culture en association de froment et de pois protéagineux d'hiver dans un objectif d'autonomie protéique
Pierreux, Jérome ULg; Delaplace, Pierre ULg; Roisin, Christian et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2016, February 24)

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See detail6. Lutte intégrée contre les maladies
Bataille, Charlotte; Duvivier, Maxime; Heens, Benoît et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2016, February 24)

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