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See detailFunctionalization of carbon xerogels for the preparation of palladium supported catalysts applied in sugar transformations
Mager, Nathalie; Meyer, Nathalie; Léonard, Alexandre ULg et al

in Applied Catalysis B : Environmental (2014), 148-149

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See detailStrategies for Using the Sheep Ovarian Cortex as a Model in Reproductive Medicine
Fransolet, Maïté ULg; Labied, Soraya ULg; HENRY, Laurie ULg et al

in PLoS ONE (2014), 9(3), 91073

Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity ... [more ▼]

Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity on the experimental results. Design: Histological study. Setting: Academic research center. Animals: Five- to nine-month-old ewes. Interventions: Freshly sampled whole sheep ovaries were collected and prepared for histological analysis. Main Outcome Measure(s): The follicular densities and distributions were determined for hematoxylin and eosin sections. A mathematical model was derived based on the follicle counts and Monte-Carlo simulations. Results: Heterogeneous distributions and densities of primordial follicles were identified 1) for distinct areas of the same ovarian cortex, 2) between the ovaries of the same animal and 3) across different ewes. A mathematical model based on the analysis of 37,153 primordial follicles from 8 different ovaries facilitated the estimation of the number of cortical biopsies and sections that had to be analyzed to overcome such heterogeneity. Conclusion: The influence of physiological follicular heterogeneity on experimental and clinical results can be overcome when a definite number of cortical pieces and sections are taken into consideration. [less ▲]

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See detailLA CURIETHÉRAPIE PROSTATIQUE PAR IMPLANTS PERMANENTS D'IODE 125- résultats après 10 ans d'expérience au CHU de Liège
HERMESSE, Johanne ULg; NICKERS, Philippe; REUL, Olivier et al

in Revue Médicale de Liège (2014), 69(Supp 1), 32-36

La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement ... [more ▼]

La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement chirurgical. La survie globale et la survie sans récidive biochimique y sont superposables, mais le profil de toxicité est différent. La plus grande opportunité de préservation de la fonction érectile, la diminution du risque d’incontinence et l’hospitalisation de jour peuvent être inté - ressantes pour le patient optant pour la curiethérapie. Par contre, la présence d’un syndrome obstructif urinaire de départ devrait orienter préférentiellement vers un traitement chirurgical. Un patient doit pouvoir faire un choix éclairé entre ces différentes possibilités thérapeutiques moyennant une information transparente et complète. Dans cet exposé, nous relatons notre expérience en curiethérapie par implants permanents d’iode 125. La survie globale, la survie libre sans récidive biochimique à long terme et la toxicité enregistrée sont similaires à celles décrites dans la littérature. [less ▲]

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See detailBis-(1,2,3,4-tetrahydroisoquinolinium): a chiral scaffold for developing high affinity ligands for SK channels
Liégeois, Jean-François ULg; Wouters, Johan; Seutin, Vincent ULg et al

in ChemMedChem (2014), 9

N-Methyl-bis-(1,2,3,4-tetrahydroisoquinolinium) analogues derived from AG525 (1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)) stereoisomers and tetrandrine, a rigid ... [more ▼]

N-Methyl-bis-(1,2,3,4-tetrahydroisoquinolinium) analogues derived from AG525 (1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)) stereoisomers and tetrandrine, a rigid bis-(1,2,3,4-tetrahydroisoquinoline) analogue with an S,S configuration, were synthesized and tested for their affinity for small-conductance calcium-activated potassium channel (SK/KCa2) subtypes using radioligand binding assays. A significant increase in affinity was observed for the quaternized analogues over the parent 1,2,3,4-tetrahydroisoquinoline compounds. Interestingly, the impact of stereochemistry was not the same in the two groups of compounds. For quaternized analogues, affinities of S,S and R,R isomers for SK2 and SK3 channels were similar and in both cases higher than that of the meso derivative. Among the bis-tetrahydroisoquinoline compounds, the S,S isomers exhibited high affinity, while the R,R and meso isomers had similarly lower affinities. Furthermore, the SK2/SK3 selectivity ratio was slightly increased for quaternized analogues. Bis-(1,2,3,4-tetrahydroisoquinolinium) represents a new scaffold for the development of high-affinity ligands for SK channel subtypes [less ▲]

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See detailINDICATIONS D’UN TRAITEMENT DE RADIOTHERAPIE LOCALE APRES PROSTATECTOMIE RADICALE
HERMESSE, Johanne ULg; WERENNE, Xavier ULg; PHILIPPI, Sven ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 29-31

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See detailCharacterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogel
Haghgoo, Majid; Yousefi, Ali Akbar; Zohouriaan Mehr, Mohammad Jalal et al

in Microporous & Mesoporous Materials (2014), 184

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See detailLa Radiothérapie: le parcours du patient, de l’information au traitement
LENNERTS, Eric ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 3-8

La radiothérapie fait partie intégrante de l’arsenal thérapeutique en oncologie et on estime que deux tiers des patients cancéreux vont bénéficier d’une radiothérapie à un moment ou un autre de leur prise ... [more ▼]

La radiothérapie fait partie intégrante de l’arsenal thérapeutique en oncologie et on estime que deux tiers des patients cancéreux vont bénéficier d’une radiothérapie à un moment ou un autre de leur prise en charge. Le parcours d’un patient en radiothérapie est pourtant souvent méconnu du corps médical et le but de cet article est de retracer celui- ci. De la prise de décision de réaliser de la radiothérapie en concertation multidisciplinaire à la délivrance des rayons par les accélérateurs linéaires, il y a la première rencontre avec le radiothérapeute, la simulation, la délimitation des volumes et la planification du traitement. La mise en route d’un trai - tement de radiothérapie demande du temps et beaucoup de précision à chaque étape. Les technologies évoluent constam - ment et la recherche en matière d’amélioration du traitement est une priorité. Le but est d’arriver à adapter individuelle - ment le traitement de radiothérapie. [less ▲]

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See detailYBa2Cu3O7-δ thick films for magnetic shielding: Electrophoretic deposition from butanol-based suspension
Closset, Raphaël ULg; Kumar, Devendra; Wera, Laurent ULg et al

in Materials Letters (2014), 119

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common ... [more ▼]

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common acetone-iodine combination. Tests with several dispersing agents reveal that a branched polyethyleneimine (PEI) dispersant develops large positive surface charge on suspended YBCO particles. As a demonstration of the performance of this new suspension formulation, a 12-layer 100 μm-thick YBCO coating was deposited on an Ag tube. The superconducting transition is sharp with onset critical temperature at 92 K. The sample can shield a magnetic field of ~1.3 mT at 77 K, i.e., the best value so far for an YBCO coating on a metallic substrate. © 2013 Elsevier B.V. [less ▲]

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See detailOrganization of microbeads in Leidenfrost droplet
Maquet, Laurent ULg; Colinet, Pierre; Dorbolo, Stéphane ULg

in Soft Matter (2014)

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See detailA Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish
Genon, Sarah ULg; Bastin, Christine ULg; Angel, Lucie et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 54

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See detailCombating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes
SCHEEN, André ULg; Van Gaal, Luc

in The Lancet Diabetes & Endocrinology (2014)

The increasing prevalence of obesity is contributing substantially to the ongoing epidemic of type 2 diabetes. Abdominal adiposity, a feature of ectopic fat syndrome, is associated with silent ... [more ▼]

The increasing prevalence of obesity is contributing substantially to the ongoing epidemic of type 2 diabetes. Abdominal adiposity, a feature of ectopic fat syndrome, is associated with silent inflammation, abnormal hormone secretion, and various metabolic disturbances that contribute to insulin resistance and insulin secretory defects, resulting in type 2 diabetes, and induce a toxic pattern that leads to cardiovascular disease, liver pathologies, and cancer. Despite the importance of weight control strategies in the prevention and management of type 2 diabetes, long-term results from lifestyle or drug interventions are generally disappointing. Furthermore, most of the classic glucose-lowering drugs have a side-effect of weight gain, which renders the management of most overweight or obese people with type 2 diabetes even more challenging. Many anti-obesity pharmacological drugs targeting central control of appetite were withdrawn from the market because of safety concerns. The gastrointestinal lipase inhibitor orlistat was the only anti-obesity drug available until the recent US, but not European, launch of phentermine–controlled-release topiramate and lorcaserin. Improved knowledge about bodyweight regulation opens new prospects for the potential use of peptides derived from the gut or the adipose tissue. Combination therapy will probably be necessary to avoid compensatory mechanisms and potentiate initial weight loss while avoiding weight regain. New glucose-lowering treatments, especially glucagon-like peptide-1 receptor agonists and sodium glucose cotransporter-2 inhibitors, offer advantages over traditional antidiabetic drugs by promoting weight loss while improving glucose control. In this Review, we explore the overlapping pathophysiology and also how various treatments can, alone or in combination, combat the dual burden of obesity and type 2 diabetes. [less ▲]

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See detailLe point de rosée en berne et la couche cornée hivernale.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; Delvenne, Philippe ULg

in Revue Médicale de Liège (2014), 69(2), 68-71

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed ... [more ▼]

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy. Keywords : Stratum corneum - Dew point [less ▲]

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See detailResponse to Dr Bolland's eLetter: Strontium and cardiovascular events.
REGINSTER, Jean-Yves ULg

in Annals of the rheumatic diseases (2014), 73(2), 9

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See detailAge-related decline in cognitive control: the role of fluid intelligence and processing speed
Manard, Marine ULg; Carabin, Delphine; Jaspar, Mathieu ULg et al

in BMC Neuroscience (2014), 15(7),

Background Research on cognitive control suggests an age-related decline in proactive control abilities whereas reactive control seems to remain intact. However, the reason of the differential age effect ... [more ▼]

Background Research on cognitive control suggests an age-related decline in proactive control abilities whereas reactive control seems to remain intact. However, the reason of the differential age effect on cognitive control efficiency is still unclear. This study investigated the potential influence of fluid intelligence and processing speed on the selective age-related decline in proactive control. Eighty young and 80 healthy older adults were included in this study. The participants were submitted to a working memory recognition paradigm, assessing proactive and reactive cognitive control by manipulating the interference level across items. Results Repeated measures ANOVAs and hierarchical linear regressions indicated that the ability to appropriately use cognitive control processes during aging seems to be at least partially affected by the amount of available cognitive resources (assessed by fluid intelligence and processing speed abilities). Conclusions This study highlights the potential role of cognitive resources on the selective age-related decline in proactive control, suggesting the importance of a more exhaustive approach considering the confounding variables during cognitive control assessment. [less ▲]

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See detailcomment j'explore les infections nosocomiales en néonatologie
Dachy, Angélique ULg; Battisti, Oreste ULg

in Revue Médicale de Liège (2014)

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See detailDermatophytes transmis par les animaux domestiques
Monod, M; Fratti, B; Mignon, Bernard ULg et al

in Revue Médicale Suisse (2014), 10

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See detailThe effect of size, weight, body compartment, sex and reproductive status on the bioaccumulation of 19 trace elements in rope-grown Mytilus galloprovincialis
Richir, Jonathan ULg; Gobert, Sylvie ULg

in Ecological Indicators (2014), 36

Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the ... [more ▼]

Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the use of bioindicator species, such as the Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819). That species has been widely used to monitor the chemical pollution of coastal ecosystems by Cr, Ni, Cu, Zn, Cd, Pb, As, Ag and V. Conversely, environmental levels of Be, Al, Fe, Mn, Co, Se, Mo, Sn, Sb and Bi have been little or not monitored so far in mussel watch programs. Bioaccumulation processes of these 19 TEs in rope-grown M. galloprovincialis purchased from a salt pond with good chemical water quality were thus investigated in the present study. Mussels efficiently accumulated the 19 studied TEs. Bioaccumulation processes were driven by numerous mutually dependent biological parameters such as the mussel size and flesh weight, the sex and the reproductive status and the body compartment considered. TE bioaccumulation was a power function of the mussel soft body dry weight; total contents linearly increased with the shell length. Small-size mussels overall concentrated more TEs, with a high inter-individual variability, consequently influencing the modelling of their bioaccumulation in the whole rope population. Although a large range of rope-grown M. galloprovincialis sizes can be used for monitoring purposes, one will thus take care not to use extreme size individuals. The influence of gametogenesis in determining female body higher TE concentrations prior to spawning could not be neglected and varied depending on the element. TEs were preferentially accumulated in the hepatopancreas, except for Zn, Se, Cd and Mo, more concentrated in gills. Gametogenesis did not influence TE distribution between body compartments, but likely diluted their concentrations as a direct consequence of massive reproductive tissue production. So, results from the present study underline the potential use of M. galloprovincialis in the biomonitoring of numerous little studied TEs and give some insights into the decisive role played by some relevant biological parameters in bioaccumulation processes of the 19 investigated TEs in rope-grown mussels. [less ▲]

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See detailFeruloylbenzotriazole and Weinreb Amide as Bioinspired Building Blocks: A Reactivity Study towards O-, N-, S-, and C-Nucleophiles
Roman, Bart; Monbaliu, Jean-Christophe ULg; De Coen, Laurens et al

in European Journal of Organic Chemistry (2014)

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See detailIdentification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis
JOSSE, Claire ULg; Bouznad, Nassim ULg; Geurts, Pierre ULg et al

in American Journal of Physiology - Gastrointestinal and Liver Physiology (2014), 306

Inflammation can contribute to tumor formation; however, markers that predict progression are still lacking. In the present study, the well-established azoxymethane (AOM)/dextran sulfate sodium (DSS ... [more ▼]

Inflammation can contribute to tumor formation; however, markers that predict progression are still lacking. In the present study, the well-established azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mouse model of colitis-associated cancer was used to analyze microRNA (miRNA) modulation accompanying inflammation-induced tumor development and to determine whether inflammation-triggered miRNA alterations affect the expression of genes or pathways involved in cancer. A miRNA microarray experiment was performed to establish miRNA expression profiles in mouse colon at early and late time points during inflammation and/or tumor growth. Chronic inflammation and carcinogenesis were associated with distinct changes in miRNA expression. Nevertheless, prediction algorithms of miRNA-mRNA interactions and computational analyses based on ranked miRNA lists consistently identified putative target genes that play essential roles in tumor growth or that belong to key carcinogenesis-related signaling pathways. We identified PI3K/Akt and the insulin growth factor-1 (IGF-1) as major pathways being affected in the AOM/DSS model. DSS-induced chronic inflammation downregulates miR-133a and miR-143/145, which is reportedly associated with human colorectal cancer and PI3K/Akt activation. Accordingly, conditioned medium from inflammatory cells decreases the expression of these miRNA in colorectal adenocarcinoma Caco-2 cells. Overexpression of miR-223, one of the main miRNA showing strong upregulation during AOM/DSS tumor growth, inhibited Akt phosphorylation and IGF-1R expression in these cells. Cell sorting from mouse colons delineated distinct miRNA expression patterns in epithelial and myeloid cells during the periods preceding and spanning tumor growth. Hence, cell-type-specific miRNA dysregulation and subsequent PI3K/Akt activation may be involved in the transition from intestinal inflammation to cancer. [less ▲]

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See detailA new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms
Sacre, Pierre-Yves ULg; Lebrun, Pierre ULg; Chavez, Pierre-François ULg et al

in Analytica Chimica Acta (2014), 818

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of ... [more ▼]

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of choice for assessing the distributional homogeneity of compounds of interest. Indeed, the combination of both spectroscopic and spatial information provides a detailed knowledge of chemical composition and component distribution. Actually, most authors assess homogeneity using parameters of the histogram of intensities (e.g. mean, skewness and kurtosis). However, this approach does not take into account spatial information and loses the main advantage of imaging. To overcome this limitation, we propose a new criterion: Distributional Homogeneity Index (DHI). DHI has been tested on simulated maps and formulation development samples. The distribution maps of the samples were obtained without validated calibration model since different formulations were under investigation. The results obtained showed a linear relationship between content uniformity values and DHI values of distribution maps. Therefore, DHI methodology appears to be a suitable tool for the analysis of homogeneity of distribution maps even without calibration during formulation development. [less ▲]

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See detailA note on abelian returns in rotation words
Rampersad, Narad; Rigo, Michel ULg; Salimov, Pavel ULg

in Theoretical Computer Science (2014), 528

Pursuing the study started by Rigo, Salimov and Vandomme, we use elementary number-theoretic techniques to characterize rotation words having a finite set of abelian returns to all prefixes. We also make ... [more ▼]

Pursuing the study started by Rigo, Salimov and Vandomme, we use elementary number-theoretic techniques to characterize rotation words having a finite set of abelian returns to all prefixes. We also make the connection between the three gap theorem and the number of semi-abelian returns for Sturmian words, simplifying some arguments developed by Puzynina and Zamboni. [less ▲]

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See detailAssessing the effects of spatial discretization on large-scale flow model performance and prediction uncertainty
Wildemeersch, Samuel ULg; Goderniaux, Pascal; Orban, Philippe ULg et al

in Journal of Hydrology (2014), 510

Large-scale physically-based and spatially-distributed models (>100 km2) constitute useful tools for water management since they take explicitly into account the heterogeneity and the physical processes ... [more ▼]

Large-scale physically-based and spatially-distributed models (>100 km2) constitute useful tools for water management since they take explicitly into account the heterogeneity and the physical processes occurring in the subsurface for predicting the evolution of discharge and hydraulic heads for several predictive scenarios. However, such models are characterized by lengthy execution times. Therefore, modelers often coarsen spatial discretization of large-scale physically-based and spatially-distributed models for reducing the number of unknowns and the execution times. This study investigates the influence of such a coarsening of model grid on model performance and prediction uncertainty. The improvement of model performance obtained with an automatic calibration process is also investigated. The results obtained show that coarsening spatial discretization mainly influences the simulation of discharge due to a poor representation of surface water network and a smoothing of surface slopes that prevents from simulating properly surface water-groundwater interactions and runoff processes. Parameter sensitivities are not significantly influenced by grid coarsening and calibration can compensate, to some extent, for model errors induced by grid coarsening. The results also show that coarsening spatial discretization mainly influences the uncertainty on discharge predictions. However, model prediction uncertainties on discharge only increase significantly for very coarse spatial discretizations. [less ▲]

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See detailEffect of land use on pollution status and risk of fish endocrine disruption in small farmland ponds
Mandiki; Gillardin; Martens et al

in Hydrobiologia (2014), 723

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See detailSocial Security and Family Support
Leroux, Marie Louise; Pestieau, Pierre ULg

in Canadian Journal of Economics (2014), 47(1), 115-143

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See detailRéviser le codage de l’égyptien ancien. Vers un répertoire partagé des signes hiéroglyphiques
Polis, Stéphane ULg; Rosmorduc, Serge

in Document Numérique (2014)

Based on an analysis of the 60 000 spellings found in the Ramses corpus, we show that the encoding scheme that is used for hieroglyphic texts, known as the Manuel de Codage (1988), is problematic for the ... [more ▼]

Based on an analysis of the 60 000 spellings found in the Ramses corpus, we show that the encoding scheme that is used for hieroglyphic texts, known as the Manuel de Codage (1988), is problematic for the development of text corpora in general. We consequently (1) argue in favour of basic principles that should be followed when encoding hieroglyphic texts in the framework of corpus projects, and (2) suggest guidelines for a new encoding scheme, especially with respect to the structure of the sign-list. [less ▲]

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See detailPenser l'espace d'après le "Parménide"
Gavray, Marc-Antoine ULg

in Dialogue : Canadian Philosophical Review = Dialogue : Revue Canadienne de Philosophie (2014)

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See detailAntioxidant capacity of small dark fruits. Influence of cultivars and harvest time
Kevers, Claire ULg; PINCEMAIL, Joël ULg; Defraigne, Jean-Olivier ULg et al

in Journal of Berry Research (2014)

BACKGROUND: Small dark fruits represent one of the most important sources of bioactive compounds with antioxidant capacity in the human diet. The content of health-promoting antioxidants in these fruits ... [more ▼]

BACKGROUND: Small dark fruits represent one of the most important sources of bioactive compounds with antioxidant capacity in the human diet. The content of health-promoting antioxidants in these fruits may be important information to take into account when a fruit producer has to choose which cultivar to grow. OBJECTIVE: It is important to know how antioxidant capacity and antioxidant compounds as total phenolics and ascorbic acid vary between 9 small dark fruit species and for each species among cultivars (2 to 10 per species). METHODS: The antioxidant capacity (ORAC assay), total phenolic (Folin-Ciocalteu) and ascorbic acid content were measured in 9 fruits (plums, blackcurrants, blackberries, blueberries, cherries, redcurrants, raspberries, white currants and gooseberries) / 42 cultivars harvested at maturity during their high production period. RESULTS: The comparison of the average of the various cultivars of each small fruits showed that blackcurrants had the best antioxidant capacity (with plums), the highest ascorbic acid content and the highest total phenolic content (with blackberries). The present study shows that total phenolic compounds, ascorbic acid and antioxidant capacity strongly differed between genotypes of each small dark fruits. Other parameters as harvest time, culture conditions and maturity degree at the harvest may also influence the antioxidant capacity of small fruits. CONCLUSION: Among small dark fruits, blackcurrants have high qualities. Choices of variety, harvest time and maturity degree are important for all fruits. [less ▲]

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See detailReprésentation du couvert forestier dans la modélisation hydrologique : Comparaison de dix modèles
Deraedt, Deborah ULg; Colinet, Gilles ULg; Claessens, Hugues ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(1), 83-96

There are many hydrological models, some of which can be used for forested environments. This review aims to compare ten of them (BILJOU, EPIC, BROOK90, SWAT, RHESSys, MIKE SHE, SHETRAN, WaSiM ETH, DHSVM ... [more ▼]

There are many hydrological models, some of which can be used for forested environments. This review aims to compare ten of them (BILJOU, EPIC, BROOK90, SWAT, RHESSys, MIKE SHE, SHETRAN, WaSiM ETH, DHSVM et Hydrus) to guide the choice. The compared fluxes are the interception, the transpiration and the root water uptake, the root distribution, the undercover effect, the tree growth and the model validation. The review underlines that each model deals with the forest fluxes in different ways. Most of the time, interception is similarly dealt by the models and the root distribution is used in the process of root water uptake. Understory and growth are seldom considered. [less ▲]

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See detailUnited but (un)equal: human capital, probability of divorce, and the marriage contract
Cremer, Helmuh; Pestieau, Pierre ULg; Roeder, Kerstin

in Journal of Population Economics (2014)

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See detailPore-filling of Spiro-OMeTAD determined by Rutherford backscattering spectrometry in templated TiO2 photoelectrodes
Dewalque, Jennifer ULg; Colson, Pierre ULg; Thalluri, Venkata Visveswara Gopala Kris ULg et al

in Organic Electronics (2014), 15

Liquid-state dye-sensitized solar cells can suffer from electrolyte evaporation and leakage. Therefore solid-state hole transporting materials are investigated as alternative electrolyte materials ... [more ▼]

Liquid-state dye-sensitized solar cells can suffer from electrolyte evaporation and leakage. Therefore solid-state hole transporting materials are investigated as alternative electrolyte materials. However, in solid-state dye-sensitized solar cells, optimal TiO2 films thickness is limited to a few microns allowing the adsorption of only a low quantity of photoactive dye and thus leading to poor light harvesting and low conversion efficiency. In order to overcome this limitation, high surface area templated films are investigated as alternative to nanocrystalline films prepared by doctor-blade or screen-printing. Moreover, templating is expected to improve the pore accessibility what would promote the solid electrolyte penetration inside the porous network, making possible efficient charge transfers. In this study, films prepared from different structuring agents are discussed in terms of microstructural properties (porosity, crystallinity) as well as impact on the dye loading and Spiro-OMeTAD (2,2',7,7'-tetrakis-(N,N-di-p-methoxyphenylamine)9,9'-spirobifluorene) solid electrolyte filling. We first report Rutherford backscattering spectrometry as an innovative non-destructive tool to characterize the hole transporting materials infiltration. Templated films show dye loading more than two times higher than nanocrystalline films prepared by doctor-blade or screen-printing and solid electrolyte infiltration up to 88%. [less ▲]

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See detailEndothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesis
Heusschen, Roy ULg; Schulkens, Iris; van Beijnum, Judy et al

in Biochimica et Biophysica Acta - Molecular Basis of Disease (2014)

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See detailImpact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning all-SCT from a HLA-identical sibling donor : a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation
Baron, Frédéric ULg; Labopin, M.; Blaise, D. et al

in Bone Marrow Transplantation (2014)

The impact of in vivo T-cell depletion on transplantation outcomes in patients transplanted with reduced-intensity conditioning (RIC) remains controversial. This study assessed the outcome of 1250 adult ... [more ▼]

The impact of in vivo T-cell depletion on transplantation outcomes in patients transplanted with reduced-intensity conditioning (RIC) remains controversial. This study assessed the outcome of 1250 adult patients with de novo AML in first CR (CR1) given PBSC from HLA-identical siblings after chemotherapy-based RIC. A total of 554 patients did not receive any form of in vivo T-cell depletion (control group), whereas antithymocyte globulin (ATG) and alemtuzumab were given in 444 and 252 patients, respectively. The incidences of grade II-IV acute GVHD were 21.4, 17.6 and 10.2% in control, ATG and alemtuzumab patients, respectively (Po0.001). In multivariate analysis, the use of ATG and the use of alemtuzumab were each associated with a lower risk of chronic GVHD (Po0.001 each), but a similar risk of relapse, and of nonrelapse mortality, and similar leukemia-free survival and OS. Further, among patients given BU-based RIC, the use of o6 mg/kg ATG did not increase the risk of relapse (hazard ratio, HR¼1.1), whereas there was a suggestion for higher relapse risk in patients given X6 mg/kg ATG (HR¼1.4, P¼0.08). In summary, these data suggest that a certain amount of in vivo T-cell depletion can be safely used in the conditioning of AML patients in CR1 given PBSC after chemotherapy-based RIC. [less ▲]

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See detailThe Benefits of Errorless Learning for Serial Reaction Time Performance in Alzheimer's Disease.
Schmitz, Xavier ULg; Bier, Nathalie; Joubert, Sven et al

in Journal of Alzheimer's Disease [=JAD] (2014), 39(2), 287-300

Identifying the conditions favoring new procedural skill learning in Alzheimer’s disease (AD) could be important for patients’ autonomy. It has been suggested that error elimination is beneficial during ... [more ▼]

Identifying the conditions favoring new procedural skill learning in Alzheimer’s disease (AD) could be important for patients’ autonomy. It has been suggested that error elimination is beneficial during skill learning, but no study has explored the advantage of this method in sequential learning situations. In this study, we examined the acquisition of a 6-element perceptual-motor sequence by AD patients and healthy older adults (control group). We compared the impact of two preliminary sequence learning conditions (Errorless vs. Errorful) on Serial Reaction Time performance at two different points in the learning process. A significant difference in reaction times for the learned sequence and a new sequence was observed in both conditions in healthy older participants; in AD patients, the difference was significant only in the errorless condition. The learning effect was greater in the errorless than the errorful condition in both groups. However, while the errorless advantage was found at two different times in the learning process in the AD group, in the control group this advantage was observed only at the halfway point. These results support the hypothesis that errorless learning allows for faster automation of a procedure than errorful learning in both AD and healthy older subjects. [less ▲]

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See detailUne Histoire d'hypophyse, évolution des représentations et des concepts au fil du temps.
JEDIDI, Haroun ULg; JEDIDI, Zayd ULg; BECKERS, Albert ULg

in Revue Médicale de Liège (2014)

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez ... [more ▼]

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez paradoxal de constater que malgré l’importance de ce système, celui-ci ait été presque complètement méconnu par les physiologistes des siècles passés. En nous basant sur les conceptions physiologiques des médecins philosophes de l’antiquité puis du moyen-âge et de la renaissance nous tenterons de comprendre pourquoi le rôle de l’hypophyse a été si longtemps méconnu. [less ▲]

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See detailThe role of the youth in community forestry in Gabon
Boldrini, Sylvie; Meunier, Quentin; Gillet, Pauline et al

in Nature et Faune (2014), 28(1), 56-59

In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus ... [more ▼]

In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus, communities however rarely integrate the youth (between the ages of 16 to 24) who reside permanently in the village in village associations. The youth are generally excluded from the decision making process of elders. In fact, the youth that reside permanently in the village do not generally hold any diploma and have no professional qualification. Consequently, they are hardly respected by the people around them and their opinions are not taken into account. They are left out of any activity conducted by the associations unless these activities are remunerated. However, the involvement of the youth in village associations is necessary, not only to increase the work capacity, but also to ensure the perpetuation of interventions since the youth will be the first and future beneficiaries of the community forest. [less ▲]

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See detailLand rights as an engine of growth ? An analysis of Cambodian landgrabs in the context of development theory
Rudi, Lisa-Marie; Azadi, Hossein; Witlox, Frank et al

in Land Use Policy (2014), (38), 564-572

Forceful evictions have become a serious problem in Cambodia with an increasing number of fami-lies being deprived of their land, homes and livelihoods without compensation. This article analysesCambodian ... [more ▼]

Forceful evictions have become a serious problem in Cambodia with an increasing number of fami-lies being deprived of their land, homes and livelihoods without compensation. This article analysesCambodian land rights in the context of economic development theory. It assesses whether increas-ing economic inequalities, stemming from forceful evictions, can be categorized as an impediment toCambodian economic growth. The Cambodian case illustrates that a lack of good governance due tocorruption leads to the unequal distribution of land which, in turn, causes inequitable economic devel-opment. The paper concludes that Cambodia is trapped in a vicious cycle of inequality, which is upheld byelites who benefit from evictions and land concessions while evictees become trapped in poverty. Giventhat the population is growing angrier, the article warns of potential for a violent revolution that couldhave disastrous consequences for the Cambodian kingdom, a country that recently emerged from yearsof civil conflicts and is still in the process of rebuilding its social fabric. [less ▲]

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See detailModeling and Simulation of Heat and Mass Transfer During Convective Drying of Wastewater Sludge with Introduction of Shrinkage Phenomena
Bennamoun, Lyes ULg; Fraikin, Laurent ULg; Léonard, Angélique ULg

in Drying Technology (2014), 32(1), 13-22

Wastewater sludge is dried in a convective dryer using air temperatures varying from 80°C to 200°C, velocities changing from 1 m · s−1 to 2 m · s−1, and humidities ranging from . The convective dryer is ... [more ▼]

Wastewater sludge is dried in a convective dryer using air temperatures varying from 80°C to 200°C, velocities changing from 1 m · s−1 to 2 m · s−1, and humidities ranging from . The convective dryer is equipped with a camera and an infrared pyrometer to follow respectively the external surface and the temperature of the product. The experimental results show that drying kinetic can be divided into three phases: two short first phases, called adaptation and constant drying phases, and a long third phase, called falling drying rate phase. As the moisture content decreases, the camera confirms simultaneous shrinkage effect with the volume reduction of the product of about 30–45% of the initial volume. Moreover, an increase of the product temperature towards air temperature was measured with the infrared pyrometer. In a second step of this study, the experimental results are modeled and simulated using heat and mass balances applied to the product and the heated air. The drying curve is rightly expressed with fourth-degree polynomial model with a correlation coefficient that approximates the unity and with low calculated errors. An outstanding determination of the heat transfer coefficient has permitted calculating the product temperature with good agreement with experimental results. The heat transfer coefficient expressed by means of Nusselt number is presented as a function of Reynolds and Prandlt numbers, changeable with air and product characteristics taking into account shrinkage effect. Moreover, as the applied air temperatures are sufficiently high, transfer by radiation is not neglected and is introduced in the mathematical model. [less ▲]

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See detailMulti-scale modeling of mycosubtilin lipopeptides at the air/water interface: structure and optical second harmonic generation
Loison, Claire; Nasir, Mehmet Nail ULg; Benichou, Emmanuel et al

in Physical Chemistry Chemical Physics [=PCCP] (2014), 16

Monolayers of the lipopeptide mycosubtilin are studied at the air/water interface. Their structure is investigated using molecular dynamics simulations. All-atom models suggest that the lipopeptide is ... [more ▼]

Monolayers of the lipopeptide mycosubtilin are studied at the air/water interface. Their structure is investigated using molecular dynamics simulations. All-atom models suggest that the lipopeptide is flexible and aggregates at the interface. To achieve simulation times of several microseconds, a coarse-grained (CG) model based on the MARTINI force field was also used. These CG simulations describe the formation of half-micelles at the interface for surface densities up to 1 lipopeptide per nm2. In these aggregates, the tyrosine side chain orientation is found to be constrained: on average, its main axis, as defined along the C–OH bond, aligns along the interface normal and points towards the air side. The origin of the optical second harmonic generation (SHG) from mycosubtilin monolayers at the air/water interface is also investigated. The molecular hyperpolarizability of the lipopeptide is obtained from quantum chemistry calculations. The tyrosine side chain contribution to the hyperpolarizability is found to be dominant. The orientation distribution of tyrosine, associated with a dominant hyperpolarizability component along the C–OH bond of the tyrosine, yields a ratio of the susceptibility elements χ(2)ZZZ/χ(2)ZXX consistent with the experimental measurements recently reported by M. N. Nasir et al. [Phys. Chem. Chem. Phys., 2013, 15, 19919]. [less ▲]

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See detailSpatial patterns and morphology of termite ( Macrotermes falciger ) mounds in the Upper Katanga, D.R. Congo
Mujinjya, Baile Baziraké; Adam, Marielle; Mees, Florias et al

in Catena (2014), 114

This study examines the spatial distribution patterns and morphological characteristics of Macrotermes falciger mounds in the peri-urban zone of Lubumbashi, D.R. Congo. Spatial patterns of mounds were ... [more ▼]

This study examines the spatial distribution patterns and morphological characteristics of Macrotermes falciger mounds in the peri-urban zone of Lubumbashi, D.R. Congo. Spatial patterns of mounds were assessed using high-resolution satellite images for 24 plots of variable size (3 to 27 ha). Soil morphological features were described for five termite-mound profiles of 5 to 9 m depth/height. A mean areal number density of 2.9 ± 0.4 mounds ha−1 is estimated for the degraded miombo woodland of the study area. Spatial statistical analyses document that termite mounds are regularly distributed in all studied plots. The overall mean nearest-neighbour distance between termite mounds is 44.6 ± 0.6 m. The high relative number of inactive mounds in the region, with regular distribution patterns, suggests that current termite mound occurrences are largely relict features.There are no clear indications for an impact of the nature of the parent material on the spatial distribution of the mounds. One aspect of differences in morphology between the studied mounds is that the stone layer occurs at greater depth in topographic low areas than at crest and slope positions. This is interpreted as being mainlyconditionedbyerosion.Mn–Fe oxideconcentrationsoccurringinallstudiedtermite moundprofiles reflect a seasonally high perched water table beneath the mound, which is more pronounced at lower landscape positions. In summary, mound positions in the habitat are consistent with intraspecific competition rather than soil and substrate characteristics as controlling factor, whereas variation in morphological characteristics between termite-mound profiles appears to be a function of the parent material [less ▲]

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See detailL’hypothermie induite dans l'encéphalopathie anox--ischémique du nouveau-né
BARREA, Christophe ULg; Seghaye, Marie-Christine ULg; Battisti, Oreste ULg

in Percentile (2014)

physiopathologie de l'asphyxie à terme et logique des traitements par hypothermie.

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See detailGene expression pattern of synovial cells from inflammatory and normal areas of osteoarthritis synovial membrane.
Lambert, Cécile ULg; Dubuc, Jean-Emile; Montell, Eulalia et al

in Arthritis and Rheumatism (2014), sous presse

Objective: The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same ... [more ▼]

Objective: The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same osteoarthritis (OA) patient. Methods: Synovial tissues were obtained from 12 knee OA patients at the time of total knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria and sorted as N/R and I. Biopsies were cultured separately for 7 days. Microarray gene expression profiling between N/R and I areas was performed. Western blot and immunohistochemistry confirmed the identified genes that were differentially expressed. Results: 896 differentially expressed genes between N/R and I zones were identified. The key pathways were related to inflammation, cartilage metabolism, Wnt signaling and angiogenesis. In the inflammatory network, TREM1 and S100A9 were strongly up-regulated. MMP-3 and -9, cathepsin H and S were significantly up-regulated in the cartilage catabolism pathway, whereas the most up-regulated anabolism enzyme was HAS1. Wnt-5A and LRP5 were up-regulated whereas FZD2 and DKK3 were down-regulated in the Wnt signaling. Finally, STC1, a protein involved in angiogenesis was identified as the most up-regulated gene in I zones compared to N/R zones. Conclusion: This study is the first to identify different expression pattern between two areas of the synovial membrane in the same patient. These differences concern several key pathways involved in OA pathogenesis. This analysis also provides information regarding new genes and proteins as potential targets for the future therapeutic. (c) 2013 American College of Rheumatology. [less ▲]

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See detailNew role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline ULg; Deroyer, Céline ULg; Renert, Anne-Françoise et al

in Autophagy (2014)

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]

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See detailProcedural learning across modalities in French-speaking children with specific language impairment
Gabriel, Audrey ULg; Meulemans, Thierry ULg; Parisse, Christophe et al

in Applied Psycholinguistics (2014)

It has been suggested that the language problems encountered in specific language impairment (SLI) arise from basal ganglia abnormalities that lead to impaired procedural memory. However, recent serial ... [more ▼]

It has been suggested that the language problems encountered in specific language impairment (SLI) arise from basal ganglia abnormalities that lead to impaired procedural memory. However, recent serial reaction time (SRT) studies did not reveal any differences between the SLI and typically developing (TD) groups on the measures of procedural memory linked to visual sequence learning. In this paper, 16 children with and without SLI were compared on two versions of SRT tasks: a visual task and an auditory one. The results showed that children with SLI were as fast as their TD peers in both modalities. All of the children obtained similar specific sequence learning indices, indicating that they were able to detect regularities in both modalities. Although children with SLI were as accurate as their TD peers for the visual SRT task, they made more errors than their TD peers in auditory SRT conditions. The results indicate that, in relation to procedural memory, the core of the impairment in SLI is not linked to difficulties in the detection of regularities. We argue that when children with SLI present some difficulties, the children’s weaknesses might depend on the type of processing involved (e.g., tasks involving auditory sequences). [less ▲]

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See detailReprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich, et al.
Gore, A. C.; Balthazart, Jacques ULg; Bikle, D. et al

in Frontiers in neuroendocrinology (2014), 35(1), 2-5

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See detailAmphetamine reward in food restricted mice lacking the melanin-concentrating hormone receptor-1
Geuzaine, A; Tyhon, A; Grisar, Thierry ULg et al

in Behavioural Brain Research (2014), 262

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See detailLa radicalité politique au bout du travail. Du suicide des ouvriers aux suicides en séries des employés
Cormann, Grégory ULg

in Quaderni : la Revue de la Communication (2014), 83

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See detailHigh Diversity in Cretaceous Ichthyosaurs from Europe Prior to Their Extinction
Fischer, Valentin ULg; Bardet, Nathalie; Guiomar, Myette et al

in PLoS ONE (2014), 9(1), 84709

Background: Ichthyosaurs are reptiles that inhabited the marine realm during most of the Mesozoic. Their Cretaceous representatives have traditionally been considered as the last survivors of a group ... [more ▼]

Background: Ichthyosaurs are reptiles that inhabited the marine realm during most of the Mesozoic. Their Cretaceous representatives have traditionally been considered as the last survivors of a group declining since the Jurassic. Recently, however, an unexpected diversity has been described in Upper Jurassic–Lower Cretaceous deposits, but is widely spread across time and space, giving small clues on the adaptive potential and ecosystem control of the last ichthyosaurs. The famous but little studied English Gault Formation and ‘greensands’ deposits (the Upper Greensand Formation and the Cambridge Greensand Member of the Lower Chalk Formation) offer an unprecedented opportunity to investigate this topic, containing thousands of ichthyosaur remains spanning the Early–Late Cretaceous boundary. Methodology/Principal findings: To assess the diversity of the ichthyosaur assemblage from these sedimentary bodies, we recognized morphotypes within each type of bones. We grouped these morphotypes together, when possible, by using articulated specimens from the same formations and from new localities in the Vocontian Basin (France); a revised taxonomic scheme is proposed. We recognize the following taxa in the ‘greensands’: the platypterygiines ‘Platypterygius’ sp. and Sisteronia seeleyi gen. et sp. nov., indeterminate ophthalmosaurines and the rare incertae sedis Cetarthrosaurus walkeri. The taxonomic diversity of late Albian ichthyosaurs now matches that of older, well-known intervals such as the Toarcian or the Tithonian. Contrasting tooth shapes and wear patterns suggest that these ichthyosaurs colonized three distinct feeding guilds, despite the presence of numerous plesiosaur taxa. Conclusion/Significance: Western Europe was a diversity hot-spot for ichthyosaurs a few million years prior to their final extinction. By contrast, the low diversity in Australia and U.S.A. suggests strong geographical disparities in the diversity pattern of Albian–early Cenomanian ichthyosaurs. This provides a whole new context to investigate the extinction of these successful marine reptiles, at the end of the Cenomanian. [less ▲]

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See detailSpatial Planning as a driver of change in mobility and residential energy consumption
Dujardin, Sébastien; Marique, Anne-Françoise ULg; Teller, Jacques ULg

in Energy & Buildings (2014), 68

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning ... [more ▼]

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning decisions upon energy consumption in both residential building stock and home-to-work commuting. The analysis has been conducted on a regional scale (16,844 km2) and includes urban, peri-urban and rural settlements. Those settlements that perform well in mobility also appear to perform well in terms of building energy consumption. Even though this is not generally the case, it further reveals that some rural settlements characterized by low density show good performance in terms of energy efficiency. This permits a much more progressive approach in terms of spatial planning, whereby compact cities may be viewed as part of the solution, albeit not the whole solution. [less ▲]

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See detailIdentification of pregnancy-associated glycoproteins and alpha-fetoprotein in fallow deer (Dama dama) placenta
Bériot, Mathilde ULg; Tchimbou Njanjo, Aline Flora ULg; Barbato, Olimpia et al

in Acta Veterinaria Scandinavica (2014), 56(4), 1-11

Background: This paper describes the isolation and characterization of pregnancy-associated glycoproteins (PAG) from fetal cotyledonary tissue (FCT) and maternal caruncular tissue (MCT) collected from ... [more ▼]

Background: This paper describes the isolation and characterization of pregnancy-associated glycoproteins (PAG) from fetal cotyledonary tissue (FCT) and maternal caruncular tissue (MCT) collected from fallow deer (Dama dama) pregnant females. Proteins issued from FCT and MCT were submitted to affinity chromatographies by using Vicia villosa agarose (VVA) or anti-bovine PAG-2 (R#438) coupled to Sepharose 4B gel. Finally, they were characterized by SDSPAGE and N-terminal microsequencing. Results: Four distinct fallow deer PAG (fdPAG) sequences were identified and submitted to Swiss-Prot database. Comparison of fdPAG with PAG sequences identified in other ruminant species exhibited 64 to 83% identity. Additionally, alpha-fetoprotein was identified in fetal and maternal tissues. Conclusion: Our results demonstrate the efficacy of VVA and bovine PAG-2 affinity chromatographies for the isolation of PAG molecules expressed in deer placenta. This is the first report giving four specific amino acid sequences of PAG isolated from feto-maternal junction (FCT and MCT) in the Cervidae family. [less ▲]

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See detailAsymptotic Expansion based-Method for Equivalent Statistical Linearization
Canor, Thomas ULg; Blaise, Nicolas ULg; Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2014)

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See detailLa description des zones climatiques terrestres. À propos d’Ératosthène, Hermès, 16, 3-16 POWELL et Cicéron, Songe de Scipion, 21
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2014)

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See detailFirst-principles study of the lattice dynamical properties of strontium ruthenate
Miao, Naihua ULg; Bristowe, Nicholas ULg; Xu, Bin et al

in Journal of Physics : Condensed Matter (2014), 26

By means of first-principles calculations, various properties of SrRuO3 are investigated, focusing on its lattice dynamical properties. Despite having a Goldschmidt tolerance factor very close to 1, the ... [more ▼]

By means of first-principles calculations, various properties of SrRuO3 are investigated, focusing on its lattice dynamical properties. Despite having a Goldschmidt tolerance factor very close to 1, the phonon dispersion curves of the high-temperature cubic phase of SrRuO3 show strong antiferrodistortive instabilities. The energetics of metastable phases with different tilt patterns are discussed, concluding that the coupling of oxygen rotation modes with anti-polar Sr motion plays a key role in stabilizing the Pnma phase with respect to alternative rotation patterns. Our systematic analysis confirms previous expectations and contributes to rationalizing better why many ABO3 perovskites, including metallic compounds, exhibit an orthorhombic ground state. The zone-center phonon modes of the Pnma phase have been computed, from which we propose partial reassignment of available experimental data. The full dispersion curves have also been obtained, constituting benchmark results for the interpretation of future measurements and providing access to thermodynamical properties. [less ▲]

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See detailHigher long-lasting ethanol sensitization after adolescent ethanol exposure in mice
Quoilin, Caroline; Didone, Vincent ULg; Tirelli, Ezio ULg et al

in Psychopharmacology (2014), 231

Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is ... [more ▼]

Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is a possible consequence of ethanol exposure during adolescence. Objectives. The aim of this study was to characterize the long-term alterations in the stimulant effects of ethanol and in the rate of ethanol sensitization in mice pre-exposed to ethanol during adolescence in comparison to mice pre-exposed to ethanol in adulthood. Methods. Adolescent and adult female SWISS mice were injected with saline or ethanol (2.5 or 4 g/kg) during 14 consecutive days. After a three weeks period of ethanol abstinence, mice were tested as adults before and after a second exposure to daily repeated ethanol injections. Results. All mice pre-exposed to ethanol as adults or adolescents showed higher stimulant effects when re-exposed to ethanol three weeks later. However, this enhanced sensitivity to the stimulant effects of ethanol was of significantly higher magnitude in mice repeatedly injected with high ethanol doses (4g/kg) during adolescence. Furthermore, the increased expression of ethanol stimulant effects in these mice was maintained even after a second procedure of ethanol sensitization. Conclusions. Adolescence is a critical period for the development of a sensitization to ethanol stimulant properties providing that high intermittent ethanol doses are administered. These results might contribute to explain the relationship between age at first alcohol use and risks of later alcohol problems and highlight the dangers of repeated consumption of high alcohol amounts in young adolescents. [less ▲]

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See detailThe effects of stress on singing voice accuracy
Larrouy, Pauline ULg; Morsomme, Dominique ULg

in Journal of Voice (2014), 28(1), 52-58

Objective: The quality of a music performance can be lessened or enhanced if the performer experiences stressful conditions. In addition, the quality of a sung performance requires control of the ... [more ▼]

Objective: The quality of a music performance can be lessened or enhanced if the performer experiences stressful conditions. In addition, the quality of a sung performance requires control of the fundamental frequency of the voice, which is particularly sensitive to stress. The present study aimed to clarify the effects of stress on singing voice accuracy. Methods: Thirty-one music students were recorded in a stressful condition (i.e., a music examination) and a non-stressful condition. Two groups were defined according to the challenge level of the music examination (first and second music levels). Measurements were made by self-reported state anxiety (CSAI-2R questionnaire) and by observing heart rate activity (electrocardiogram) during each performance. In addition, the vocal accuracy of the sung performances was objectively analyzed. Results: As expected, state anxiety and heart rate were significantly higher on the day of the music examination than in the non-stressful condition for all the music students. However, the effect of stress was positive for the first-year students but negative for the second-year students, for whom the music examination was particularly challenging. In addition, highly significant correlations were found between the intensity of cognitive symptoms and the vocal accuracy criteria. Discussion: This study highlights the contrasting effects of stress on singing voice accuracy but also the need to consider the challenge level and perception of the symptoms in experimental and pedagogical settings. [less ▲]

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See detailEffects of adenosine on lymphangiogenesis.
Lenoir, Bénédicte ULg; Wagner, Daniel R.; Blacher, Silvia ULg et al

in PloS one (2014), 9(3), 92715

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood ... [more ▼]

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during adulthood. Blocking lymphangiogenesis may therefore be of therapeutic interest. Production of adenosine is enhanced in the tumor environment and contributes to tumor progression through stimulation of angiogenesis. In this study, we determined whether adenosine affects lymphangiogenesis. METHODS: Lymphatic endothelial cells (HMVEC-dLy) were cultured in presence of adenosine and their proliferation, migration and tube formation was assessed. Gelatin sponges embedded with the stable analogue of adenosine 2-chloro adenosine were implanted in mice ear and lymphangiogenesis was quantified. Mice were intravenously injected with adenoviruses containing expression vector for 5'-endonucleotidase, which plays a major role in the formation of adenosine. RESULTS: In vitro, we observed that adenosine decreased the proliferation of lymphatic endothelial cells, their migration and tube formation. However, in vivo, gelatin sponges containing 2-chloro adenosine and implanted in mice ear displayed an elevated level of lymphangiogenesis (2.5-fold, p<0.001). Adenovirus-mediated over-expression of cytosolic 5'-nucleotidase IA stimulated lymphangiogenesis and the recruitment of macrophages in mouse liver. Proliferation of lymphatic endothelial cells was enhanced (2-fold, p<0.001) when incubated in the presence of conditioned medium from murine macrophages. CONCLUSION: We have shown that adenosine stimulates lymphangiogenesis in vivo, presumably through a macrophage-mediated mechanism. This observation suggests that blockade of adenosine receptors may help in anti-cancer therapies. [less ▲]

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See detailPlant selection for nest building by western lowland gorillas in Cameroon
Willie, Jacob; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Primates : Journal of Primatology (2014)

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See detailDisorders of consciousness after acquired brain injury: the state of the science
Giacino, Joseph T; Fins, Joseph J; Laureys, Steven ULg et al

in Nature Reviews Neurology (2014)

The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain ... [more ▼]

The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain injury results in the dissolution of consciousness, providing a natural model from which key insights about consciousness may be drawn. In the clinical setting, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate through word or gesture, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate and inappropriate care. In this Review, we describe the state of the science with regard to clinical management of patients with prolonged disorders of consciousness. We review consciousness-altering pathophysiological mechanisms, specific clinical syndromes, and novel diagnostic and prognostic applications of advanced neuroimaging and electrophysiological procedures. We conclude with a provocative discussion of bioethical and medicolegal issues that are unique to this population and have a profound impact on care, as well as raising questions of broad societal interest. [less ▲]

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See detailHighly dispersed Pt/C catalysts prepared by the Charge Enhanced DryImpregnation method
Cao Chongjiang; Yang Guang; Dubau Laetitia et al

in Applied Catalysis B : Environmental (2014), 150-151

tAn efficient method to synthesize highly dispersed Pt/carbon xerogel catalysts for Proton ExchangeMembrane fuel cell applications is described. The synthesis proceeds via the Charge Enhanced ... [more ▼]

tAn efficient method to synthesize highly dispersed Pt/carbon xerogel catalysts for Proton ExchangeMembrane fuel cell applications is described. The synthesis proceeds via the Charge Enhanced DryImpregnation method (CEDI), which combines dry impregnation with the Strong Electrostatic Adsorp-tion technique (SEA). The samples prepared via CEDI or SEA techniques were dried and reduced underhydrogen to obtain supported Pt nanoparticles. In order to increase the Pt mass fraction up to 10 wt.%,two successive impregnation-drying-reduction cycles were performed. The synthesized Pt nanoparticlesare homogeneously distributed on the carbon support and highly dispersed (mean Pt nanoparticle sizeof ca. 2 nm). The CEDI method is ideally suited to avoid Pt losses during the catalyst preparation. [less ▲]

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See detailMary Anning’s legacy to French vertebrate palaeontology
Vincent, Peggy; Taquet, Philippe; Fischer, Valentin ULg et al

in Geological Magazine (2014), 151(1), 7-20

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent ... [more ▼]

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent study by eminent English and French scientists. In 1820, Georges Cuvier acquired several ichthyosaur specimens found by Mary Anning, now kept or displayed in the Palaeontology Gallery of the MNHN in Paris. Four years later, Cuvier obtained a plesiosaur specimen from Mary Anning, only the second ever discovered. Cuvier was fascinated by these fossils and their study allowed him to apply his comparative anatomical method and to support his catastrophist theory. We re-examined these important specimens from an historical point of view and herein describe them taxonomically for the first time since Cuvier’s works. The Paris specimens belong to two different ichthyosaur genera (Ichthyosaurus and Leptonectes) and one plesiosaur genus (Plesiosaurus). [less ▲]

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See detailÉDITORIAL : Augmenter la visibilité de la radiothérapie
COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 1-2

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See detailImpact of the invasive Asian clam, Corbicula spp., on a large river ecosytem
Pigneur, Lise-Marie; Falisse, Elodie; Roland, Kathleen et al

in Freshwater Biology (2014), 59(3), 573-583

During the past recent decades, Asiatic clams (Corbicula spp.) have spread spectacularly in several large European rivers. In the River Meuse, a transnational lowland river, an important chlorophyll a ... [more ▼]

During the past recent decades, Asiatic clams (Corbicula spp.) have spread spectacularly in several large European rivers. In the River Meuse, a transnational lowland river, an important chlorophyll a decline has been recorded since the mid-2000s, which seems to be related to the invasion by these exotic bivalves. This study aimed at verifying that hypothesis, using clam density data from field surveys, water quality monitoring data, and a simulation model. Estimated Corbicula densities were between 50 and 900 individuals m-2, depending on the site. Using a maximum filtration rate per clam body mass of 0.086 m3 g C-1 day-1 at 20°C derived from the literature, we ran simulations with a non-stationary model to estimate the impact of the exotic bivalve on the river plankton and water quality. In the stretches where the invasive clams developed best, comparison with a clam-free scenario allowed estimating a 70 % phytoplankton biomass loss due to their filtration, leading to a 61 % loss of annual primary productivity. Model simulations also showed that zooplankton may have suffered as much as 75 % loss in terms of biomass. The simulations also point to substantial effects of the invasive Corbicula on the river oxygen budget and on nutrient cycling. We expect that, in the heavily regulated sectors of the river, the loss of planktonic production due to the invasive filter-feeders will negatively affect other suspension feeders and alter ecosystem function and productivity. [less ▲]

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See detailLA PHYSIQUE DES RADIATIONS IONISANTES POUR LES NEOPHYTES
LENAERTS, Eric ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 13-15

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès ... [more ▼]

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès majeurs en radiothérapie, visant à l’op - timisation de la distribution de la dose sur la cible et à l’exclu - sion, dans la mesure du possible, de l’irradiation des tissus sains avoisinants. Le développement de nouvelles modalités de traitement, telle l’utilisation des hadrons, est le reflet du développement de cette science. Aux confins de cette radio- physique se trouve la radiobiologie, et l’ensemble des connais - sances dans ces deux domaines permet une optimisation de la prescription médicale [less ▲]

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See detailLectures de La Reine Albemarle ou le dernier touriste. Ontologie, autobiographie, politique
Cormann, Grégory ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(1),

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See detailLigand and solvation effects on the structural and electronic properties of small gold clusters
Dufour, F.; Fresch, Barbara ULg; Durupthy, O. et al

in Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2014), 118(8), 4362

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See detaildivand-1.0: n-dimensional variational data analysis for ocean observations
Barth, Alexander ULg; Beckers, Jean-Marie ULg; Troupin, Charles ULg et al

in Geoscientific Model Development [=GMD] (2014), 7

A tool for multidimensional variational analysis (divand) is presented. It allows the interpolation and analysis of observations on curvilinear orthogonal grids in an arbitrary high dimensional space by ... [more ▼]

A tool for multidimensional variational analysis (divand) is presented. It allows the interpolation and analysis of observations on curvilinear orthogonal grids in an arbitrary high dimensional space by minimizing a cost function. This cost function penalizes the deviation from the observations, the deviation from a first guess and abruptly varying fields based on a given correlation length (potentially varying in space and time). Additional constraints can be added to this cost function such as an advection constraint which forces the analysed field to align with the ocean current. The method decouples naturally disconnected areas based on topography and topology. This is useful in oceanography where disconnected water masses often have different physical properties. Individual elements of the a priori and a posteriori error covariance matrix can also be computed, in particular expected error variances of the analysis. A multidimensional approach (as opposed to stacking 2-dimensional analysis) has the benefit of providing a smooth analysis in all dimensions, although the computational cost is increased. Primal (problem solved in the grid space) and dual formulations (problem solved in the observational space) are implemented using either direct solvers (based on Cholesky factorization) or iterative solvers (conjugate gradient method). In most applications the primal formulation with the direct solver is the fastest, especially if an a posteriori error estimate is needed. However, for correlated observation errors the dual formulation with an iterative solver is more efficient. The method is tested by using pseudo observations from a global model. The distribution of the observations is based on the position of the ARGO floats. The benefit of the 3-dimensional analysis (longitude, latitude and time) compared to 2-dimensional analysis (longitude and latitude) and the role of the advection constraint are highlighted. The tool divand is free software, and is distributed under the terms of the GPL license (http://modb.oce.ulg.ac.be/mediawiki/index.php/divand). [less ▲]

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See detailImpact of purification and fractionation process on the chemical structure and physical properties of locust bean gum
Gillet, Sébastien ULg; Blecker, Christophe ULg; Aguedo, Mario ULg et al

in Carbohydrate Polymers (2014)

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on ... [more ▼]

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on the residual impoverished fraction (GM80). The complete structural characterization has shown that GM80 possessed relatively longer chain lengths than GM25, a slightly lower degree of galactose substitution and a somewhat sharper galactosyl distribution in substituted and unsubstituted regions. A physical behavior analysis was carried out on solubilization kinetics, viscosity, viscoelasticity and formation of associated gels with xanthan or carrageenan. The average structure of GM80 generated larger intra-chain, inter-chain and inter-molecular interactions, resulting in the appearance of a stronger network. Small structural differences therefore generated very different physical behaviors. This study thus allowed to establish, in a precise and complete manner, fractionation-purification-structure-function relationships of galactomannans extracted from carob. [less ▲]

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See detailStability of templated and nanoparticles dye-sensitized solar cells : photovoltaic and electrochemical investigation of degradation mechanisms at the photoelectrode interface
Dewalque, Jennifer ULg; Nguyen, Ngoc Duy ULg; Colson, Pierre ULg et al

in Electrochimica Acta (2014), 115(1), 478-486

A key issue in the commercialization of dye-sensitized solar cells is to maintain high efficiency and long lifetime. As reported in the literature, dye-sensitized solar cells are stable under visible ... [more ▼]

A key issue in the commercialization of dye-sensitized solar cells is to maintain high efficiency and long lifetime. As reported in the literature, dye-sensitized solar cells are stable under visible light soaking but thermal stress and UV exposure lead to efficiency degradation. However, all the stability studies published so far have been performed on cells whose TiO2 electrodes were prepared by tape casting or screen printing of nanoparticle pastes/inks. The present study concerns cells based on highly porous templated TiO2 electrodes, whose larger surface area could enhance the negative effects of thermal stress, light soaking and UV exposure. The long-term stability of these cells is compared with a classical nanoparticle-based cell using current-voltage measurements (I-V curves) and electrochemical impedance spectroscopy. Due to their higher active interface, templated cells are more sensitive than nanoparticle cells to UV illumination, although this can be easily solved in both cases by the use of a UV filter. The templated cells are as stable as the nanoparticle cells under visible light soaking (UV filtered). However, we showed that templated cells are more stable under thermal stress. Moreover, as evidenced by electrochemical impedance spectroscopy, templated cells show lower transfer resistance, as well as lower recombination resistance compared to nanoparticle cells. The crystallite connectivity promoted by the templating route seems to favor the electron transfers inside the porous layer. Using templated films in dye-sensitized solar cells is therefore really promising because higher conversion efficiencies are reached without promoting cell degradation. [less ▲]

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See detailCoherent Backscattering in Fock Space: A Signature of Quantum Many-Body Interference in Interacting Bosonic Systems
Engl, Thomas; Dujardin, Julien ULg; Argüelles, Arturo et al

in Physical Review Letters (2014), 112

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with ... [more ▼]

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with respect to variations of external parameters even though it represents a dynamical manifestation of the delicate superposition principle in Fock space. It is a genuine quantum many-body effect that lies beyond the reach of any mean-field approach. Using a semiclassical approach based on interfering paths in Fock space, we calculate the magnitude of the backscattering peak and its dependence on gauge fields that break time-reversal invariance. We confirm our predictions by comparing them to exact quantum evolution probabilities in Bose-Hubbard models, and discuss their relevance in the context of many-body thermalization. [less ▲]

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See detailMultifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms
NCHIMI LONGANG, Alain ULg; CHERAMY-BIEN, Jean-Paul ULg; Gasser, T. Christian et al

in Circulation. Cardiovascular imaging (2014), 7

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG ... [more ▼]

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET). METHODS AND RESULTS: -The study included 53 patients (45 males) with aortic aneurysms, 47 infrarenal (AAA) and 6 thoracic (TAA), who had at least one 18F-FDG PET/computed tomography. Over a 30-month period, more clinical events occurred in patients with increased 18F-FDG uptake on their last examination than in those without (5/18 (28%) vs. 2/35 (6%); P=0.03). Wall stress and stress/strength index computed by FES and 18F-FDG uptake were evaluating a total of 68 examinations. 25 (38%) examinations demonstrated at least one aneurysm wall area of increased 18F-FDG uptake. The mean number of these areas per examination was 1.6 (18/11) in TAAs vs. 0.25 (14/57) in AAAs, while the mean number of increased uptake areas co-localizing with highest wall stress and stress/strength index areas was 0.55 (6/11) and 0.02 (1/57), respectively. Quantitatively, 18F-FDG PET uptake correlated positively with both wall stress and stress/strength index (P<0.05). 18F-FDG uptake was particularly high in subjects with personal history of angina pectoris and familial aneurysm. CONCLUSIONS: -Increased 18F-FDG PET uptake in aortic aneurysms is strongly related to aneurysm location, wall stress as derived by FES and patient's risk factors such as acquired and inherited susceptibilities. [less ▲]

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See detailLong-term fracture rates seen with continued ibandronate treatment : pooled analysis of DIVA and MOBILE long-term extension studies
Miller, PD; Recker, RR; Harris, S et al

in Osteoporosis International (2014), 25(1), 349-357

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See detailLE CYBERKNIFE AIME LES DEFIS ! Aperçu d'indications pour la radiothérapie extracrânienne robotisée
JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 87-93

Toute l’histoire de la radiothérapie illustre la quête continue vers une distribution de dose la plus haute possible sur la cible tumorale, tout en réduisant au maximum l’irra - diation des tissus sains ... [more ▼]

Toute l’histoire de la radiothérapie illustre la quête continue vers une distribution de dose la plus haute possible sur la cible tumorale, tout en réduisant au maximum l’irra - diation des tissus sains. La radiothérapie en conditions stéréo - taxiques est la suite logique de cette évolution tant au niveau de la précision d’exécution du traitement qu’au niveau de la concentration de la dose, et donc de l’efficacité du traitement. Cette technique a d’abord été mise en application clinique pour des lésions intra-crâniennes. Une radiothérapie de haute précision ne peut être sensible aux mouvements incontrôlés de la cible. Vu la nécessité en clinique d’aborder les mêmes concepts de précision et d’efficacité pour des cibles extra-crâ - niennes, il a fallu développer des solutions qui permettent de tenir compte du mouvement de la cible. Les solutions infor - matiques et robotiques ont été combinées dans le concept du CyberKnife ® . Nous présentons cette technique particulière d’irradiation et voulons faire part de l’expérience des deux premières années acquise au CHU de Liège. Nous voulons également revoir les indications potentielles de cette radiothé - rapie de très haute précision [less ▲]

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See detailLignin extraction from Mediterranean agro-wastes: Impact of pretreatment conditions on lignin chemical structure and thermal degradation behavior
Manara, Panagiota; Zabaniotou, Anastasia; Vanderghem, Caroline ULg et al

in Catalysis Today (2014), 223

Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical ... [more ▼]

Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical one. The organosolv process included lignocellulosic biomass treatment with formic acid/acetic acid/water (30/50/20, v/v%), for 3 h at 107 °C, while the physicochemical method was conducted by immersing the biomass in a water/ethanol (8/92, v/v%), H2SO4 0.32 M, solvent and further exposing the slurry to microwave irradiation (maximum 250 W) for 1/2 h at 150 °C. Both processes were evaluated regarding the achieved delignification and the purity of the extracted lignins. The effect of the pretreatment processes onto the structure and thermal decomposition behavior of the extracted lignins was investigated via FT-IR and TGA analysis, respectively. The objective of the research work was to investigate potential valorization routes for these biomass agro-residues in the context of a biorefinery, focusing on lignin extraction. The pretreatment results showed that the obtained lignins, derived from both procedures, were of high purity (>82 wt%). Under the organosolv procedure, peach kernel delignification showed the maximum value (∼16 wt%), while under microwave pretreatment, olive kernel delignification showed the maximum value (∼35 wt%). Grape pomace/seeds appeared to be the most resistant in both treatments. [less ▲]

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See detailLong-Term Care Insurance and Family
Pestieau, Pierre ULg; Canta, Chiara

in B.E. Journal of Economic Analysis & Policy (2014)

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See detailA new Lower Cretaceous ichthyosaur from Russia reveals skull shape conservatism within Ophthalmosaurinae
Fischer, Valentin ULg; Arkhangelsky, Maxim; Uspensky, Gleb et al

in Geological Magazine (2014), 151(1), 60-70

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late ... [more ▼]

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late Jurassic ophthalmosaurine Ophthalmosaurus is often regarded as a hyperspecialized deep diver, very little is known about the anatomy, evolutionary history, and ecology of Cretaceous ophthalmosaurines because of the scarcity of the fossils and the lack of well-preserved skull material. Here, we describe the skull of a new basal ophthalmosaurine ichthyosaur, Leninia stellans gen. et sp. nov., from the lower Aptian of western Russia, and compare the ocular characteristics of ophthalmosaurids. Leninia is recovered as a basal ophthalmosaurine; it possesses unique traits such as star-shaped frontal–parietal sutures as well as features previously thought to be unique to Ophthalmosaurus such as a supratemporal–stapes contact. A large sclerotic aperture – significantly bigger than in platypterygiine ophthalmosaurids and similar to that of the largest-eyed modern animals (giant and colossal squids) – and reduced dentition appear widespread within ophthalmosaurines. This conservatism suggests ophthalmosaurine ophthalmosaurids occupied similar ecological niche(s) throughout their long evolutionary history. [less ▲]

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See detailInflorescence development in tomato: gene functions within a zigzag model.
Périlleux, Claire ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg

in Frontiers in Plant Science (2014), 5

Tomato is a major crop plant and several mutants have been selected for breeding but also for isolating important genes that regulate flowering and sympodial growth. Besides, current research in ... [more ▼]

Tomato is a major crop plant and several mutants have been selected for breeding but also for isolating important genes that regulate flowering and sympodial growth. Besides, current research in developmental biology aims at revealing mechanisms that account for diversity in inflorescence architectures. We therefore found timely to review the current knowledge of the genetic control of flowering in tomato and to integrate the emerging network into modeling attempts. We developped a kinetic model of the tomato inflorescence development where each meristem was represented by its ‘vegetativeness’ (V), reflecting its maturation state towards flower initiation. The model followed simple rules: maturation proceeded continuously at the same rate in every meristem (dV); floral transition and floral commitment occurred at threshold levels of V; lateral meristems were initiated with a gain of V (ΔV) relative to the V level of the meristem from which they derived. This last rule created a link between successive meristems and gave to the model its zigzag shape. We next exploited the model to explore the diversity of morphotypes that could be generated by varying dV and ΔV and matched them with existing mutant phenotypes. This approach, focused on the development of the primary inflorescence, allowed us to elaborate on the genetic regulation of the kinetic model of inflorescence development. We propose that the lateral inflorescence meristem fate in tomato is closer to an immature flower meristem than to the inflorescence meristem of Arabidopsis. In the last part of our paper, we extend our thought to spatial regulators that should be integrated in a next step for unraveling the relationships between the different meristems that participate to sympodial growth. [less ▲]

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See detailUn monde entre accélération et incertitudes
Santander, Sébastian ULg

in Interventions Economiques = Papers in Political Economy (2014)

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See detailL’INTÉRÊT DE LA RADIOTHÉRAPIE «ABLATIVE» EN PRENANT COMME MODÈLE LA MÉTASTASE D’UN CANCER RÉNAL À CELLULES CLAIRES
COUCKE, Philippe ULg; JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 94-100

La radiothérapie en conditions stéréotaxiques, guidée par l’imagerie embarquée, est une alternative valable aux autres modalités de traitement ablatif, en particulier dans le contexte du cancer rénal ... [more ▼]

La radiothérapie en conditions stéréotaxiques, guidée par l’imagerie embarquée, est une alternative valable aux autres modalités de traitement ablatif, en particulier dans le contexte du cancer rénal métastatique (mRCC). L’efficacité du traitement dépend de la dose totale et la dose par fraction et se traduit en Dose Biologique Efficace (BED). Les tech - niques actuelles permettent d’appliquer des doses par frac - tion élevée (> 8 à 10 Gy), ce qui se traduit en effet biologique fondamentalement différent de celui observé dans le contexte d’une radiothérapie conventionnelle, résultant en un taux de réponse local atteignant 80 à 90%. Ce taux de réponse contre - dit le concept historique de tumeur «radiorésistante». L’effet thérapeutique s’explique en partie par un effet anti-angiogé - nique majeur induit par la réponse apoptotique des cellules endothéliales dans la tumeur. Ceci ouvre de nouvelles perspec - tives, en particulier dans le domaine des traitements combi - nant radiothérapie ablative et substances anti-angiogéniques. [less ▲]

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See detailComparative evaluation of existing and new methods for correcting ocular artifacts in electroencephalographic recordings
Kirkove, Murielle ULg; François, Clémentine ULg; Verly, Jacques ULg

in Signal Processing (2014), 98(C), 102-120

EEG signals are often contaminated by ocular artifacts (OAs), in particular when they are recorded for a subject that is, in principle, awake, such as in a study of drowsiness. It is generally desirable ... [more ▼]

EEG signals are often contaminated by ocular artifacts (OAs), in particular when they are recorded for a subject that is, in principle, awake, such as in a study of drowsiness. It is generally desirable to detect and/or correct these OAs before interpreting the EEG signals. We have identified 11 existing methods for dealing with OAs. Their study allowed us to create 16 new methods. We performed a comparative performance evaluation of the resulting 27 distinct methods using a common set of data and a common set of metrics. The data was recorded during a driving task of about two hours in a driving simulator. This led to a ranking of all methods, with five emerging clear winners, comprising two existing methods and three new ones. [less ▲]

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See detailMagnetic ghosts and monopoles
Vandewalle, Nicolas ULg; Dorbolo, Stéphane ULg

in New Journal of Physics (2014), 16

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See detailCombined effects of climate, resource availability, and plant traits on biomass produced in a Mediterranean rangeland
Chollet, Simon; Rambal, Serge; Fayolle, Adeline ULg et al

in Ecology (2014), 95(3), 737-748

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities ... [more ▼]

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities. However, the combined effects of these different factors remain largely unknown. The aim of the present study was to unravel the causes of variations in the standing biomass of plant communities using a long-term experiment conducted in a Mediterranean rangeland of Southern France. Two management regimes, sheep grazing and grazing associated with mineral fertilization, were applied to different areas of the study site over the past 25 years. Abiotic (temperature, available water, nutrients) and biotic (components of the functional structure communities) factors were considered to explain interannual and spatial variations in standing biomass in these rangelands. Standing biomass was highly predictable, with the best model explaining ;80% of variations in the amount of biomass produced, but the variation explained by abiotic and biotic factors was dependent on the season and on the management regime. Abiotic factors were found to have comparable effects in both management regimes: The amount of biomass produced in the spring was limited by cold temperatures, while it was limited by water availability and high temperatures in the summer. In the fertilized community, the progressive change in the functional structure of the communities had significant effects on the amount of biomass produced: the dominance of few productive species which were functionally close led to higher peak standing biomass in spring. [less ▲]

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See detailDESIGN, MODELING AND EXPERIMANTATION OF A REVERSIBLE HP-ORC PROTOTYPE
Dumont, Olivier ULg; Quoilin, Sylvain ULg; Lemort, Vincent ULg

in Proceedings of the ASME TURBO EXPO 2014 (2014)

This paper presents an innovative system comprising a heat pump connected to a solar roof and a geothermal heat exchanger. This heat pump is also able to invert its cycle and operate as an ORC. By using ... [more ▼]

This paper presents an innovative system comprising a heat pump connected to a solar roof and a geothermal heat exchanger. This heat pump is also able to invert its cycle and operate as an ORC. By using the whole rooftop (hereunder called “absorber”) as a heat source, a large amount of heat is generated throughout the year. This heat is used in priority to cover the building annual heating needs and the surplus heat generated during the summer is utilized to generate electricity in a so-called HP/ORC module. This paper will thus focus on these two main points: designing of the prototype and results from experimentation. This paper demonstrates the feasibility of such a prototype with encouraging performance in ORC and HP modes. Experimentally, a COP of 4.2 is reached in heat pump mode and a global efficiency of 5.6 is obtained in ORC mode. Possible means of improvement and perspectives are finally described. [less ▲]

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See detailResistance of through-plate component in beam-to-column joints with circular hollow columns
Hoang, Van Long ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (2014), 92

A configuration of beam-to-column joint with circular hollow section columns is proposed. A vertical plate, called through-plate, passing through the column is used to support the beams. In order to ... [more ▼]

A configuration of beam-to-column joint with circular hollow section columns is proposed. A vertical plate, called through-plate, passing through the column is used to support the beams. In order to facilitate connecting the beams, two horizontal plates, each side of the column, are welded to the upper side of the through-plate. The lower flanges of the steel beams are connected to the horizontal plates by bolts, and the upper flanges are attached to the concrete slab by shear connections. The joint is considered as hinges in the construction phase while semi-rigid and partial strength can be adopted for the joint behaviour during the exploitation time. A development on the through-plate component of the joint is presented in this paper. Global behaviour of the joint under hogging moment and shear force is analysed leading to a mechanical model of the through-plate component. Using the elastic buckling theory of plates, the analytical formulas for critical stresses of the through-plate are obtained. The coefficients taking into account boundary conditions, material plasticity and geometrical imperfection are determined by finite element analysis. The proposed model is validated by experimental results showing a good accuracy. The design guideline for the component is finally provided for the practical purpose. [less ▲]

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See detailThe Threshold Photoelectron Spectrum of Geminal Chloro-Fluoro-ethene (1,1-C2H2FCl) isomer. Experiment and Theory.
Locht, Robert ULg; Dehareng, Dominique ULg; Leyh, Bernard ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (2014), 47(8), 0851019

The threshold photoelectron spectrum (TPES) of 1,1-C2H2FCl has been measured for the first time using synchrotron radiation. It has been compared to the HeI photoelectron spectrum (PES) obtained earlier ... [more ▼]

The threshold photoelectron spectrum (TPES) of 1,1-C2H2FCl has been measured for the first time using synchrotron radiation. It has been compared to the HeI photoelectron spectrum (PES) obtained earlier [Tornow G. et al., Chem.Phys. 146 115 (1990)]. Eight photoelectron bands have been observed at 10.22 eV, 12.45 eV, 13.28 eV, 14.29 eV, 14.99 eV, 17.12 eV, 17.67 eV, and at 20.23 eV successively. Only the first three bands exhibit a rich and extensive vibrational structure. Their adiabatic ionization energies are measured and a detailed vibrational analysis is presented. The assignments of the electronic bands and of the vibrational wavenumbers were made by using ab initio quantum chemical calculations. These allowed us to provide the MO description of the eight electronic states in terms of ionization and double excitation. The good correlation between predicted vibrational wavenumbers and the experimental values provides a strong basis for the assignment of all the vibrational structures. [less ▲]

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See detailFinal Overall Survival: Fulvestrant 500 mg vs 250 mg in the Randomized CONFIRM Trial.
Leo, Angelo Di; Leo, Angelo Di; Jerusalem, Guy ULg et al

in Journal of the National Cancer Institute (2014), 106(1), 337

BACKGROUND: At the time of the initial analysis of overall survival (OS) for the Comparison of Faslodex in Recurrent or Metastatic Breast Cancer (CONFIRM) randomized, double-blind, phase III trial ... [more ▼]

BACKGROUND: At the time of the initial analysis of overall survival (OS) for the Comparison of Faslodex in Recurrent or Metastatic Breast Cancer (CONFIRM) randomized, double-blind, phase III trial, approximately 50% of patients had died. A final analysis of OS was subsequently planned for when 75% of patients had died. METHODS: Patients were randomly assigned 1:1 to fulvestrant 500 mg administered as two 5-mL intramuscular injections on days 0, 14, and 28 and every 28 (+/-3) days thereafter or fulvestrant 250 mg administered as two 5-mL intramuscular injections (one fulvestrant and one placebo [identical in appearance to study drug]) on days 0, 14 (two placebo injections only), and 28 and every 28 (+/-3) days thereafter. OS was analyzed using an unadjusted log-rank test. No adjustments were made for multiplicity. Serious adverse events (SAEs) and best response to subsequent therapy were also reported. All statistical tests were two-sided. RESULTS: In total, 736 women (median age = 61.0 years) were randomly assigned to fulvestrant 500mg (n = 362) or 250mg (n = 374). At the final survival analysis, 554 of 736 (75.3%) patients had died. Median OS was 26.4 months for fulvestrant 500mg and 22.3 months for 250mg (hazard ratio = 0.81; 95% confidence interval = 0.69-0.96; nominal P = .02). There were no clinically important differences in SAE profiles between the treatment groups; no clustering of SAEs could be detected in either treatment group. Type of first subsequent therapy and objective responses to first subsequent therapy were well balanced between the two treatment groups. CONCLUSIONS: In patients with locally advanced or metastatic estrogen receptor-positive breast cancer, fulvestrant 500mg is associated with a 19% reduction in risk of death and a 4.1-month difference in median OS compared with fulvestrant 250mg. Fulvestrant 500mg was well tolerated, and no new safety concerns were identified. [less ▲]

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See detailContrasting patterns of phytoplankton communities in two coastal ecosystems in relation to environmental factors (Corsica, NW Mediterranean Sea)
Garrido, Marie; Goffart, Anne ULg; Collignon, Amandine ULg et al

in Diversity (2014), 6

Corsica Island is a sub-basin of the Northwestern Mediterranean Sea, with hydrological features typical of both oligotrophic systems and eutrophic coastal zones. Phytoplankton assemblages in two coastal ... [more ▼]

Corsica Island is a sub-basin of the Northwestern Mediterranean Sea, with hydrological features typical of both oligotrophic systems and eutrophic coastal zones. Phytoplankton assemblages in two coastal ecosystems of Corsica (the deep Bay of Calvi and the shallow littoral of Bastia) show contrasting patterns over a one-year cycle. In order to determine what drives these variations, seasonal changes in littoral phytoplankton are considered together with environmental parameters. Our methodology combined a survey of the physico-chemical structure of the subsurface water with a characterization of the phytoplankton community structure. Sampling provided a detailed record of the seasonal changes and successions that occur in these two areas. Results showed that the two sampled stations presented different phytoplankton abundance and distribution patterns, notably during the winter–spring bloom period. Successions in pico-, nano-, and microphytoplankton communities appeared mainly driven by differences in the ability to acquire nutrients, and in community-specific growth rates. Phytoplankton structure and dynamics are discussed in relation to available data on the Northwestern Mediterranean Sea. These results confirm that integrated monitoring of coastal areas is a requisite for gaining a proper understanding of marine ecosystems. [less ▲]

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See detailObservation <–> Text(e) <–> Culture. Introduction
Badir, Sémir ULg

in Semiotica (2014), 198

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See detailMyeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis.
Nzeusseu Toukap, A.; Delporte, C.; Noyon, C. et al

in Free radical research (2014), 48(4), 461-5

Abstract Objective. Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is ... [more ▼]

Abstract Objective. Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is a link between oxidative stress and cytokines. The present study aims at investigating the link between synovial MPO (and its products), interleukin (IL)-18, which is involved in the degradation of articular cartilage in RA, and IL-8, which is involved in recruitment and activation of neutrophils during inflammation. Effects of the treatment of RA on the biological parameters were also investigated. Methods. Patients (n = 105) were studied including 39 patients with OA, 33 with RA and 33 with RA receiving a specific treatment. Disease activity score (DAS-28) was calculated whereas MPO antigen/activity, neutrophils, chloro-tyrosine (Cl-Tyr), homocitrulline (Hcit), IL-8, and IL-18 were measured in synovial fluid (SF) and CRP was measured in serum. Results. DAS-28 and CRP levels were not significantly different between groups. MPO activity, and MPO, Cl-Tyr, and Hcit levels were significantly higher in SF of RA patients than OA patients. MPO specific activity (MPO activity/antigen ratio) was significantly lower in treated than in untreated RA patients as was IL-8. MPO activity and concentration were correlated with IL-8 and IL-18 in untreated but not in treated RA patients. Conclusions. MPO level is related to IL-8 and IL-18 levels in untreated RA patients. A link has been shown between treatment and decrease of IL-8, MPO specific activity and Hcit in SF. The causal role of MPO in SF inflammation and how treatment can affect MPO specific activity need further investigations. [less ▲]

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See detailConstitutional Aspects of FTAs: a Colombian Perspective
Parra Santamaria, Lusmiriam Andrea ULg; De Lombaerde, Philippe; Lizarazo, Liliana et al

in European Journal of Law (2014)

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See detailBayesian methods for predicting LAI and soil water content
Mansouri, Majdi ULg; Dumont, Benjamin ULg; Leemans, Vincent ULg et al

in Precision Agriculture (2014), 15(2), 184-201

LAI of winter wheat (Triticum aestivum L.) and soil water content of the topsoil (200 mm) and of the subsoil (500 mm) were considered as state variables of a dynamic soil-crop system. This system was ... [more ▼]

LAI of winter wheat (Triticum aestivum L.) and soil water content of the topsoil (200 mm) and of the subsoil (500 mm) were considered as state variables of a dynamic soil-crop system. This system was assumed to progress according to a Bayesian probabilistic state space model, in which real values of LAI and soil water content were daily introduced in order to correct the model trajectory and reach better future evolution. The chosen crop model was mini STICS which can reduce the computing and execution times while ensuring the robustness of data processing and estimation. To predict simultaneously state variables and model parameters in this non-linear environment, three techniques were used: Extended Kalman Filtering (EKF), Particle Filtering (PF), and Variational Filtering (VF). The significantly improved performance of the VF method when compared to EKF and PF is demonstrated. The variational filter has a low computational complexity and the convergence speed of states and parameters estimation can be adjusted independently. Detailed case studies demonstrated that the root mean square error (RMSE) of the three estimated states (LAI and soil water content of two soil layers) was smaller and that the convergence of all considered parameters was ensured when using VF. Assimilating measurements in a crop model allows accurate prediction of LAI and soil water content at a local scale. As these biophysical properties are key parameters in the crop-plant system characterization, the system has the potential to be used in precision farming to aid farmers and decision makers in developing strategies for site-specific management of inputs, such as fertilizers and water irrigation. [less ▲]

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See detailKluge, Adorno et l’indomptable Leni Peickert
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Cahiers du GRM (2014), 5

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