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See detailChemical composition, vasorelaxant, antioxidant and antiplatelet effects of essential oil of Artemisia campestris L. from Oriental Morocco
Dib, Ikram; Fauconnier, Marie-Laure ULg; Sindic, Marianne ULg et al

in BMC Complementary and Alternative Medicine (2017), 17(art. 82), 1-15

Background: Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A ... [more ▼]

Background: Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A. campestris L (AcEO) and to investigate the antiplatelet, antioxidant effects and the mechanisms of its vasorelaxant effect. Methods: The chemical composition of AcEO was elucidated using GC/MS analysis. Then, the antioxidant effect was tested on DPPH radical scavenging and on the prevention of β-carotene bleaching. The antiplatelet effect was performed on the presence of the platelet agonists: thrombin and ADP. The mechanism of action of the vasorelaxant effect was studied by using the cellular blockers specified to explore the involvement of NO/GC pathway and in the presence of calcium channels blockers and potassium channels blockers. Results: AcEO is predominated by the volatiles: spathulenol, ß-eudesmol and p-cymene. The maximal antioxidant effect was obtained with the dose 2 mg/ml of AcEO. The dose 1 mg/ml of AcEO showed a maximum antiplatelet effect of, respectively 49.73% ±9.54 and 48.20% ±8.49 on thrombin and ADP. The vasorelaxation seems not to be mediated via NOS/GC pathway neither via the potassium channels. However, pretreatment with calcium channels blockers attenuated this effect, suggesting that the vasorelaxation is mediated via inhibition of L-type Ca2+ channels and the activation of SERCA pumps of reticulum plasma. Conclusion: This study confirms the antioxidant, antiplatelet and vasorelaxant effects of A.campestris L essential oil. However, the antihypertensive use of this oil should be further confirmed by the chemical fractionation and subsequent bio-guided assays. [less ▲]

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See detailEmbedded solids of any dimension in the X-FEM. Part II - Imposing Dirichlet boundary conditions
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series ... [more ▼]

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. While the first paper is devoted to the design of a dedicated P1 function space to solve elliptic equations defined on manifolds of codimension one or two (curves in 2D and surfaces in 3D, or curves in 3D), the general treatment of Dirichlet boundary conditions, in such a setting, remains to be addressed. This is the aim of this second paper. A new algorithm is introduced to build a stable Lagrange multiplier space from the traces of the shape functions defined on the background mesh. It is general enough to cover: (i) boundary value problems investigated in the first paper (with, for instance, Dirichlet boundary conditions defined along a line in a 3D mismatching mesh); but also (ii) those posed on manifolds of codimension zero (a domain embedded in a mesh of the same dimension) and already considered in Béchet et al. 2009. In both cases, the compatibility between the Lagrange multiplier space and that of the bulk approximation (the dedicated P1 function space used in (i), or classical shape functions used in (ii)) — resulting in the inf–sup condition — is investigate through the numerical Chapelle-Bath test. Numerical validations are performed against analytical and finite element solutions on problems involving 1D or 2D boundaries embedded in a 2D or 3D background mesh. Comparisons with Nitsche’s method and the stable Lagrange multiplier space proposed in Hautefeuille et al. 2012, when they are feasible, highlight good performance of the approach. [less ▲]

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See detailChemical Composition and Acaricidal Activity of Thymus algeriensis Essential Oil against Varroa destructor
Kouache, Benmoussa; Brada, Moussa; Saadi, Abdelkader et al

in Natural Product Communications (2017), 12(0), 1-4

The aim of the present study was to determine the chemical composition and evaluate the acaricidal activity of Thymus algeriensis essential oil (TAEO) against Varroa destructor. This ectoparasitic mite is ... [more ▼]

The aim of the present study was to determine the chemical composition and evaluate the acaricidal activity of Thymus algeriensis essential oil (TAEO) against Varroa destructor. This ectoparasitic mite is a pest of the honey bee Apis mellifera. The essential oil from the aerial parts of T. algeriensis, obtained by hydrodistillation, was obtained in a yield of 2.8± 0.2%, w/w. The TAEO was analyzed by GC and GC/MS. Thirty-four compounds were identified, representing 99.3% of the oil. The main constituents were carvacrol (48.4%), γ-terpinene (14.9%), p-cymene (14.7%), and thymol (5.6%). Four lots were constituted at the level of an apiary in order to study the dynamics of the Varroa destructor and its host, Apis mellifera. After diagnosis by the biological method "install of diapers", the lots were treated at different doses of TAEO (0.1, 0.3 and 0.5%). TAEO was sprayed on top of the hives. The results show that TAEO at 0.5% resulted in a decrease in the rate of infestation of Varroa destructor, causing a mortality rate of 32.6% without negative effect on the nesting of the queen. The essential oil of T. algeriensis could be used as a bioacaricidal agent. [less ▲]

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See detailThe global burden of chronic kidney disease: estimates, variability and pitfalls.
Glassock, RJ; Warnock, DG; DELANAYE, Pierre ULg

in Nature Reviews Nephrology (2017), 13(2), 104-114

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See detailThe role of fatty acid beta-oxidation in lymphangiogenesis.
Wong, Brian W.; Wang, Xingwu; Zecchin, Annalisa et al

in Nature (2017), 542(49),

Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in ... [more ▼]

Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in transgenic mouse models, LEC-specific loss of CPT1A, a rate-controlling enzyme in fatty acid beta-oxidation, impairs lymphatic development. LECs use fatty acid beta-oxidation to proliferate and for epigenetic regulation of lymphatic marker expression during LEC differentiation. Mechanistically, the transcription factor PROX1 upregulates CPT1A expression, which increases acetyl coenzyme A production dependent on fatty acid beta-oxidation. Acetyl coenzyme A is used by the histone acetyltransferase p300 to acetylate histones at lymphangiogenic genes. PROX1-p300 interaction facilitates preferential histone acetylation at PROX1-target genes. Through this metabolism-dependent mechanism, PROX1 mediates epigenetic changes that promote lymphangiogenesis. Notably, blockade of CPT1 enzymes inhibits injury-induced lymphangiogenesis, and replenishing acetyl coenzyme A by supplementing acetate rescues this process in vivo. [less ▲]

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See detailEmbedded solids of any dimension in the X-FEM. Part I - Building a dedicated P1 function space
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape ... [more ▼]

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape functions, it introduces an algorithm to reduce the function space into an equivalent space having the same properties than a P1 Lagrange approximation. Convergence studies involving problems of codimension one or two embedded in 2D or 3D show good accuracy with regard to classical finite element and analytical solutions. The effects of the relative position of the domain with respect to the mesh are studied in a sensitivity analysis; it illustrates how the proposed solution allows to keep the condition number bounded. A comparative study is performed with the method introduced by Olshanskii et al. 2009 on a closed surface to validate our approach. The robustness of the proposed approach is investigated with regard to their method and that of Burman et al. 2016. This paper is the first in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. It investigates problems involving borderless domains or domains with boundary subject to Dirichlet constraint defined only on the boundaries of the bulk mesh, while the forthcoming paper overcomes this limitation by introducing a new stable Lagrange multiplier space for Dirichlet boundary condition (and more generally stiff condition), that is valid for every combination of the background mesh and manifold dimensions. The combination of both algorithms allows to handle any embedding i.e. 1D, 2D and 3D problems embedded in 2D or 3D background meshes. [less ▲]

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See detailFish habitat selection in a large hydropeaking river: Strong individual and temporal variations revealed by telemetry
Capra, Hervé; Plichard, Laura; Bergé, Julien et al

in Science of the Total Environment (2017), 578

Modeling individual fish habitat selection in highly variable environments such as hydropeaking rivers is required for guiding efficient management decisions. We analyzed fish microhabitat selection in ... [more ▼]

Modeling individual fish habitat selection in highly variable environments such as hydropeaking rivers is required for guiding efficient management decisions. We analyzed fish microhabitat selection in the heterogeneous hydraulic and thermal conditions (modeled in two-dimensions) of a reach of the large hydropeaking Rhône River locally warmed by the cooling system of a nuclear power plant. We used modern fixed acoustic telemetry techniques to survey 18 fish individuals (five barbels, six catfishes, seven chubs) signaling their position every 3 s over a three-month period. Fish habitat selection depended on combinations of current microhabitat hydraulics (e.g. velocity, depth), past microhabitat hydraulics (e.g. dewatering risk or maximum velocities during the past 15 days) and to a lesser extent substrate and temperature. Mixed-effects habitat selection models indicated that individual effects were often stronger than specific effects. In the Rhône, fish individuals appear to memorize spatial and temporal environmental changes and to adopt a “least constraining” habitat selection. Avoiding fast-flowing midstream habitats, fish generally live along the banks in areas where the dewatering risk is high. When discharge decreases, however, they select higher velocities but avoid both dewatering areas and very fast-flowing midstream habitats. Although consistent with the available knowledge on static fish habitat selection, our quantitative results demonstrate temporal variations in habitat selection, depending on individual behavior and environmental history. Their generality could be further tested using comparative experiments in different environmental configurations. [less ▲]

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See detailImpaired familiarity in individuals at risk for Alzheimer's disease: Commentary on Schoemaker et al. (2016)
Bastin, Christine ULg; Besson, Gabriel ULg

in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017), 6

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See detailStudy of the photocatalytic activity of Fe3+, Cr3+, La3+ and Eu3+ single-doped and co-doped TiO2 catalysts produced by aqueous sol-gel processing
Malengreaux, Charline; Pirard, Sophie ULg; Léonard, Géraldine ULg et al

in Journal of Alloys and Compounds (2017), 691

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination ... [more ▼]

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination step, has been adapted to produce Fe3+, Cr3+, La3+ or Eu3+ single-doped TiO2 photocatalysts as well as La3+-Fe3+ and Eu3+-Fe3+ co-doped TiO2 catalysts. The physicochemical properties of the obtained catalysts have been characterized using a suite of complementary techniques, including ICP-AES, XRD, UV-Vis spectroscopy, nitrogen adsorption-desorption and Fe-57 Mössbauer. The active crystalline phase is obtained without requiring any calcination step and all the different catalysts are composed of nanocrystallites of anatase with a size of 6-7 nm and a high specific surface area varying from 181 to 298 m² g-1. In this study, the effect of the NO3:Ti(IV) mole ratio used to induce the peptisation reaction during the synthesis has been studied and the results revealed that this ratio can influence significantly the textural properties of the resulting catalyst. A screening of the photocatalytic activity of the undoped and Fe3+, Cr3+, La3+ or Eu3+ single-doped and co-doped photocatalysts has been performed by evaluating the degradation of 4-nitrophenol under UV-Visible light (330 nm < λ < 800 nm). This study suggests that the photocatalytic activity is significantly influenced by the dopant nature and content with an optimal dopant content being observed in the case of Fe3+ or La3+ single-doped as well as in the case of La3+-Fe3+ and Eu3+-Fe3+ co-doped catalysts. In the case of Cr3+ single-doped catalysts, a detrimental effect of the dopant on the photocatalytic degradation of 4-nitrophenol has been observed while no significant influence of the dopant has been detected in the case of Eu3+ single-doped catalysts. The role of the different dopants in modulating the photocatalytic activity is discussed. [less ▲]

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See detailInvestigation of the added mass method for seismic design of lock gates
Buldgen, Loïc ULg; Le Sourne, Hervé; Caprace, Jean-David ULg et al

in Engineering Structures (2017)

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See detailMono- and bimetallic manganese-carbonyl complexes and clusters bearing imidazol(in)ium-2-dithiocarboxylate ligands
Beltran Alvarez, Tomás Francisco ULg; Zaragoza, Guillermo; Delaude, Lionel ULg

in Dalton Transactions (2017), 46

Five complexes with the generic formula fac-[MnBr(CO)3(S2C[middle dot]NHC)] were obtained by reacting [MnBr(CO)5] with a set of representative imidazol(in)ium-2-dithiocarboxylate zwitterions. These ... [more ▼]

Five complexes with the generic formula fac-[MnBr(CO)3(S2C[middle dot]NHC)] were obtained by reacting [MnBr(CO)5] with a set of representative imidazol(in)ium-2-dithiocarboxylate zwitterions. These ligands are the adducts of N-heterocyclic carbenes (NHCs) and carbon disulfide. The mononuclear Mn(i) derivatives were coupled with Na[Mn(CO)5] to afford bimetallic [Mn2(CO)6(S2C[middle dot]NHC)] clusters. Yet, the most convenient strategy to access these dinuclear Mn(0) products implied a direct carbonyl substitution from the [Mn2(CO)10] dimer. The molecular structures of three monometallic and four bimetallic compounds were elucidated by single crystal X-ray diffraction analysis. In the monometallic complexes, the NHC[middle dot]CS2 ligands exhibited a bidentate [small kappa]2-S,S[prime or minute] coordination mode with an S-C-S bite angle of about 116[degree]. In the dinuclear clusters, the CS2- unit acted as a chelate toward one manganese center and as a pseudoallylic ligand toward the other one. The S-C-S bite angle was reduced to ca. 104[degree]. Thus, the zwitterions displayed a remarkable flexibility, which also permitted a staggered arrangement of the carbonyl groups in the bimetallic systems. Examination of the [small nu, Greek, macron]CO absorption bands on IR spectroscopy helped identify the presence of fac-Mn(CO)3 or Mn2(CO)6 motifs, while the 13C NMR chemical shift of the CS2- moiety was a reliable indicator for monitoring its hapticity. Whereas the dinuclear clusters were air- and moisture-stable crystalline solids, mononuclear halido derivatives displayed only a limited stability under aerobic conditions. Both types of compounds underwent rather unselective, extensive fragmentations in the gas phase, in sharp contrast with the analogous rhenium derivatives that led to clean sequential decarbonylation processes upon collision-induced dissociation. [less ▲]

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See detailConcise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.
Franco, Benedicte; Malgrange, Brigitte ULg

in Stem cells (Dayton, Ohio) (2017)

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice ... [more ▼]

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice harbor some progenitor cells that retain the ability to give rise to new hair cells. These progenitor cells are in fact supporting cells. Upon hair cells loss, those cells are able to generate new hair cells both by direct transdifferentiation or following cell cycle re-entry and differentiation. However, this property of supporting cells is progressively lost after birth. Here, we review the molecular mechanisms that are involved in mammalian hair cell development and regeneration. Manipulating pathways used during development constitute good candidates for inducing hair cell regeneration after injury. Despite these promising studies, there is still no evidence for a recovery following hair cells loss in adult mammals. Stem Cells 2017. [less ▲]

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See detailMRI follow-up is unnecessary in patients with macroprolactinomas and long-term normal prolactin levels on dopamine agonist treatment.
Eroukhmanoff, J.; Tejedor, I.; Potorac, Iulia ULg et al

in European Journal of Endocrinology (2017), 176(3), 323-328

OBJECTIVE: Both antitumor and antisecretory efficacies of dopamine agonists (DA) make them the first-line treatment of macroprolactinomas. However, there is no guideline for MRI follow-up once prolactin ... [more ▼]

OBJECTIVE: Both antitumor and antisecretory efficacies of dopamine agonists (DA) make them the first-line treatment of macroprolactinomas. However, there is no guideline for MRI follow-up once prolactin is controlled. The aim of our study was to determine whether a regular MRI follow-up was necessary in patients with long-term normal prolactin levels under DA. PATIENTS AND METHODS: We conducted a retrospective multicenter study (Marseille, Paris La Pitie Salpetriere and Nancy, France; Liege, Belgium) including patients with macroprolactinomas (largest diameter: >10 mm and baseline prolactin level: >100 ng/mL) treated by dopamine agonists, and regularly followed (pituitary MRI and prolactin levels) during at least 48 months once normal prolactin level was obtained. RESULTS: In total, 115 patients were included (63 men and 52 women; mean age at diagnosis: 36.3 years). Mean baseline prolactin level was 2224 +/- 6839 ng/mL. No significant increase of tumor volume was observed during the follow-up. Of the 21 patients (18%) who presented asymptomatic hemorrhagic changes of the macroprolactinoma on MRI, 2 had a tumor increase (2 and 7 mm in the largest size). Both were treated by cabergoline (1 mg/week) with normal prolactin levels obtained for 6 and 24 months. For both patients, no further growth was observed on MRI during follow-up at the same dose of cabergoline. CONCLUSION: No significant increase of tumor size was observed in our patients with controlled prolactin levels on DA. MRI follow-up thus appears unnecessary in patients with biologically controlled macroprolactinomas. [less ▲]

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See detailCenozoic vegetation gradients in the mid- and higher latitudes of central Eurasia and climatic implications
Popova, S.; Utescher, T.; Gromyko, D. V. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

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See detailSystemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD.
Stolz, Daiana; Leeming, Diana Julie; Edfort Kristensen, Jacob Hull et al

in CHEST (2017)

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic ... [more ▼]

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic obstructive pulmonary disease (COPD). We aimed to assess the association of ECM turnover with severity and outcome of COPD. METHODS: In a prospective, observational, multicenter study including 506 patients with COPD, GOLD grades II-IV, we analyzed serum samples at stable state, exacerbation and 4 weeks after exacerbation, for a panel of 5 novel neo-epitopes including fragments of collagen type-III (C3M) and type-VI (C6M), pro-forms of collagen type-III (Pro-C3) and type-VI (Pro-C6) and neutrophil elastase-generated fragments of elastin (EL-NE) by ELISA. These neo-epitopes were also measured at stable state in a derivation cohort including 100 COPD patients. RESULTS: Serum levels of C3M, C6M, Pro-C3, Pro-C6 and EL-NE were associated with lung function. Patients with the lowest levels of Pro-C3 and Pro-C6 had more severe airflow limitation, hyperinflation, air trapping, and emphysema. Degradation of collagen type-III and -VI was associated with dyspnea. All ECM biomarkers, except Pro-C6, were increased at exacerbation as compared to stable state but, except EL-NE, did not differ between stable state and exacerbation follow-up in the crude and adjusted analyses. In Cox regression adjusted analyses, Pro-C3 was associated with a shorter time to exacerbation (HR 0.72[0.59-0.89] p=0.002) and Pro-C6 with survival (HR 2.09[1.18-3.71], p=0.011). CONCLUSIONS: Serum biomarkers of ECM turnover are significantly associated with disease severity and clinically relevant outcomes in COPD. [less ▲]

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See detailFifth European Dirofilaria and Angiostrongylus Days (FiEDAD) 2016
Simón, F.; Kartashev, V.; González-Miguel, J. et al

in Parasites & Vectors (2017), 10(1), 5

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See detailSimilarity of the Jovian satellite footprints: spots multiplicity and dynamics
Bonfond, Bertrand ULg; Grodent, Denis ULg; Badman, S. V. et al

in Icarus (2017)

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the ... [more ▼]

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the planet. Called satellite footprints, these auroral features appear either as a single spot (Europa and Enceladus) or as multiple spots (Io and Ganymede). Moreover, they can be followed by extended trailing tails in the case of Io and Europa, while no tail has been reported for Ganymede and Enceladus, yet. Here we show that all Jovian footprints can be made of several spots. Furthermore, the footprints all experience brightness variations on timescale of 2-3 minutes. We also demonstrate that the satellite location relative to the plasma sheet is not the only driver for the footprint brightness, but that the plasma environment and the magnetic field strength also play a role. These new findings demonstrate that the Europa and Ganymede footprints are very similar to the Io footprint. As a consequence, the processes expected to take place at Io, such as the bi-directional electron acceleration by Alfvén waves or the partial reflection of these waves on plasma density gradients, can most likely be extended to the other footprints, suggesting that they are indeed universal processes. [less ▲]

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See detailShip collision analysis on Offshore Wind Turbine monopile foundations
Bela, Andreea ULg; Le Sourne, Hervé; Buldgen, Loïc ULg et al

in Marine Structures (2017), 51

An offshore wind farm covers a large maritime area and the site can be located close to traffic lanes of commercial and passenger ships, which may lead to possible collision events. The work presented in ... [more ▼]

An offshore wind farm covers a large maritime area and the site can be located close to traffic lanes of commercial and passenger ships, which may lead to possible collision events. The work presented in this paper aimed to understand both the crushing behavior and the nacelle dynamics of a predefined monopile offshore wind turbine when impacted by a ship. Another objective was to deeply investigate the influence of various parameters like ship impact velocity and location, wind direction, soil stiffness and deformability of the striking ship. First, nonlinear numerical simulations of ship - Offshore Wind Turbine (OWT) collisions have been carried out with a rigid striking ship for a better understanding of the OWT’s structural behaviour during collision. Different configurations for the wind turbine’s structure have been used in order to highlight the modifications in behaviour induced by changing the soil conditions or the loading scenario. The resulting resistant force and internal energies have been compared as well as the tower top (nacelle) displacements and accelerations. Then, another series of simulations have been performed with a deformable ship in order to investigate the influence of the deformability of the striking ship on the OWT’s behaviour. It is worth noting that all these numerical results will further serve to fix the hypotheses for the development of a simplified tool based on analytical formulations. [less ▲]

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See detailThoracic endovascular aortic repair (TEVAR) in proximal (type A) aortic dissection: Ready for a broader application?
Nienaber, Christoph A.; Sakalihasan, Natzi ULg; Clough, Rachel E. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2017)

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role ... [more ▼]

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role in managing proximal aortic pathologies is unknown-this is important because in proximal (Stanford type A) aortic dissections, 10% to 30% are not accepted for surgery and 30% to 50% are technically amenable for TEVAR. We describe our case series of type A aortic dissections treated by using TEVAR. METHODS: Between year 2009 and 2016, 12 patients with acute, subacute, or chronic type A aortic dissection with the proximal entry tear located between the coronaries and brachiocephalic artery were treated with TEVAR at 3 centers. Various stent-graft configurations were used to seal the proximal entry tear in the ascending aorta under rapid pacing. RESULTS: A total of 12 patients (9 male, 3 female), mean age 81 +/- 7 years, EuroSCORE II 9.1 +/- 4.5, underwent TEVAR for the treatment of type A aortic dissection. Procedural success was achieved in 11 of 12 patients (91.7%). There was 1 minor stroke and 1 intraprocedural death. No additional deaths were reported at 30 days. At 36 months, there were 4 further deaths (all from nonaortic causes). The mean survival of these 4 deceased was 23 months (range 15-36 months). Follow-up computed tomography demonstrated favorable aortic remodeling. CONCLUSIONS: TEVAR is feasible and reveals promising early results in selected patients with type A aortic dissection who are poor candidates for surgical repair. The current iteration of stent-graft technology, however, needs to be adapted to features specific to the ascending aorta. [less ▲]

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See detailEvaluation of the long-term effect of biochar on properties of temperate agricultural soil at pre-industrial charcoal kiln sites in Wallonia, Belgium
Hardy, Brieuc; Cornelis, Jean-Thomas ULg; Houben, David et al

in European Journal of Soil Science (2017), 68

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See detailQue peut la doctrine en droit et sociétés (et ailleurs)?
Thirion, Nicolas ULg

in Revue Pratique des Sociétés - Tijdschrift voor Rechtspersoon en Vennootschap (2017), 1

A quelle condition la doctrine peut-elle relever d'une démarche proprement scientifique? Telle est la question qu'abord cet éditorial.

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See detailDeciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme
Barroca, M.; Santos, G.; Johansson, B. et al

in Enzyme and Microbial Technology (2017), 96

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See detailEstrogen receptors and estetrol-dependent neuroprotective actions: a pilot study.
Tskitishvili, Ekaterine ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Journal of Endocrinology (2017), 232(1), 85-95

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen ... [more ▼]

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/proliferating effects of E4 on H2O2-induced oxidative stress in primary hippocampal cell cultures were studied using different combinations of specific inhibitors for ERalpha (MPP dihydrochloride), ERbeta (PHTTP), GPR30 (G15) and palmytoilation (2-BR). LDH activity and cell survival assays were performed. In vivo the promyelinating role of different concentrations of E4 (1 mg/kg/day, 5 mg/kg/day, 10 mg/kg/day, 50 mg/kg/day) was investigated using the hypoxic-ischemic brain damage model in the 7-day-old immature rats before/after the induction of hypoxic-ischemic insult. Myelin basic protein (MBP) immunostaining was performed on brain coronal sections. Our results show that LDH activity is significantly upregulated in cell cultures where the E4's effect was completely blocked by concomitant treatment either with ERalpha and ERbeta inhibitors (MPP and PHTPP, respectively), or ERalpha and ERbeta inhibitors combined with 2-BR. Cell survival is significantly downregulated in cell cultures where the effect of E4 was blocked by ERbeta inhibitor (PHTTP) alone. The blockage of GRP30 receptor did affect neither LDH activity nor cell survival. MBP immunostaining is significantly upregulated in E4-pretreated groups at a concentration of 5 mg/kg/day and 50 mg/kg/day E4, whereas the MBP-positive area OD ratio is significantly increased in all the E4-treated groups. E4's antioxidative actions mostly depend on ERalpha and ERbeta, whereas neurogenesis and possibly promyelinating activities might be realized through ERbeta. [less ▲]

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See detailDéficits de la conscience autonoétique et de la mémoire autobiographique: résultats d'une intervention cognitive dans la schizophrénie.
Boulanger, Marie ULg; Neumann, Aurore; Blairy, Sylvie ULg

in Pratiques Psychologiques (2017)

The study evaluates the effects of a cognitive intervention called Self-Awareness Therapy (SAT) on abilities of mental time travel in deficit in schizophrenia. Among whole schizophrenia participants ... [more ▼]

The study evaluates the effects of a cognitive intervention called Self-Awareness Therapy (SAT) on abilities of mental time travel in deficit in schizophrenia. Among whole schizophrenia participants, seven participated in SAT, four took part in the Integrative Program Therapy (IPT) and six followed a treatment as usual. Before and after interventions, participants were asked to complete TEMPau for autonoetic awareness and autobiographical memory such as TeMA, for autobiographical memory and projection into future events. Intragroups and individual statistical analyses were conducted. The participants of SAT intervention reported more specific past TEMPau and future specific events on TeMA after therapy. Results support that, in schizophrenia, the retrieving of past specific memories and projection into future specific events could be improved under certain conditions only. [less ▲]

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See detailExtreme intra-clutch egg size dimorphism is not coupled with corresponding differences in antioxidant capacity and stable isotopes between eggs
Poisbleau, Maud; Beaulieu, Michaël; Dehnhard, Nina et al

in Comparative Biochemistry and Physiology Part A : Molecular & Integrative Physiology (2017), 205

Oviparous females need to allocate resources optimally to their eggs in order to maximize their fitness. Among these resources, dietary antioxidants, acquired by females and transferred to the eggs during ... [more ▼]

Oviparous females need to allocate resources optimally to their eggs in order to maximize their fitness. Among these resources, dietary antioxidants, acquired by females and transferred to the eggs during egg formation, can greatly affect the development and survival of the embryo and chick. In crested penguins, incubation starts after the second and last egg is laid and, as opposed to many other bird species, this egg hatches first, thereby enhancing the survival of the chick. Here, we assessed whether antioxidant and isotopic composition could underlie these differences between eggs within clutches of southern rockhopper penguins (Eudyptes chrysocome chrysocome). The second-laid egg had higher total antioxidant capacity than the first-laid egg, although this was not due to higher antioxidant concentration but to its higher mass. This suggests that resources are allocated by females at a constant rate in both eggs within clutches. Accordingly, we found a strong correlation for isotopic compositions between eggs suggesting that resources were allocated similarly to each egg within the clutch. Overall, we found little evidence for a significant role of antioxidant and isotopic compositions to explain differences in terms of embryo/chick development between eggs in crested penguins. However, since our results suggest a constant rate of antioxidant transfer from females to eggs, limiting the mass of the first-laid egg might represent a strategy for females to spare antioxidant defences and preserve self-maintenance. [less ▲]

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See detailPeur de l'intimité dans la relation amoureuse adolescente : L'implication de l'attachement parental et de l'attachement romantique
Courtain, Audrey ULg; Glowacz, Fabienne ULg

in Annales Médico-Psychologiques (2017)

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment ... [more ▼]

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment and the internal working models related to it, while being colored by the emerging romantic attachment and its brand new internal working models. Attachments are deeply shaped by a dynamic interaction whereby the self tries to figure out how to reach security and autonomy still taking the other into account. This considered, intimacy also implies a dynamic feature: on the one hand, closeness and sharing of feelings and/or experiences, and on the other hand, individuality and maintaining of one’s ego. However, just like attachments may be insecure, a fear of intimacy cannot be underestimated during dating. Eventually, bearing in mind the societal and cultural components of attachment and intimacy, gendered explanations cannot be ignored, especially during adolescence. Objectives: Three hypotheses are being tested. First, the continuity from parental to romantic attachment is postulated, meaning that a secure, preoccupied or dismissing attachment to parents might lead to a subsequent secure, preoccupied or dismissing attachment to romantic partners. Second, the influence of parental attachment on the fear of intimacy during teen dating is questioned. The difficult dynamic of closeness/individuality might be explained by the parental attachment’s patterns. Third, the impact of romantic attachment on the fear of intimacy during teen dating is assessed. Also, dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship are studied and put in perspective with the romantic attachment. Materials and methods: The initial sample is made of 283 Belgian students (61% girls) from different teaching systems, aged of 16-22 years old (mean age : 17.43), and 232 of them had already had a dating experience by this time. They were questioned about dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship. Two questionnaires were also self-administered: the Behavioral Systems Questionnaire (assessing attachment) and the Fear of Intimacy Scale. Statistical analyses such as Pearson Chi², Anova and Post-Hoc LSD were carried out. Results: First, we cannot see any continuity between parental and romantic attachment. Second, dismissing attachment to parents fosters the fear on intimacy, compared to secure profiles; this is especially true for dismissing girls. Third, dismissing and preoccupied attachments to romantic partners foster the fear of intimacy, compared to secure profiles; this is especially true for dismissing and even more for preoccupied boys. Also, preoccupied attachment to romantic partners fosters the multiplication of datings, compared to secure; this is especially true for preoccupied and even more for dismissing girls. Finally, there is no effect of romantic attachment on the age of the first dating experience or on the longest lasting relationship. Conclusion: Parental and romantic attachments are involved in the fear of intimacy experienced by adolescents during dating. Still, attachment styles’ influence seems different for girls and boys, and highlights the need to distinguish girls’ from boys’ teen dating experiences. [less ▲]

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See detailMars Topography Investigated Through the Wavelet Leaders Method: a Multidimensional Study of its Fractal Structure
Deliège, Adrien ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

in Planetary and Space Science (2017), 136C

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based ... [more ▼]

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based on Mars Orbiter Laser Altimeter (MOLA) data using the multifractal formalism called Wavelet Leaders Method (WLM). This approach shows that a scale break occurs at approximately 15 km, giving two scaling regimes in both 1D and 2D cases. At small scales, these topographic profiles mostly display a monofractal behavior while a switch to multifractality is observed in several areas at larger scales. The scaling exponents extracted from this framework tend to be greater at small scales. In the 1D context, these observations are in agreement with previous works and thus suggest that the WLM is well-suited for examining scaling properties of topographic fields. Moreover, the 2D analysis is the first such complete study to our knowledge. It gives both a local and global insight on the scaling regimes of the surface of Mars and allows to exhibit the link between the scaling exponents and several famous features of the Martian topography. These results may be used as a solid basis for further investigations of the scaling laws of the Red planet and show that the WLM could be used to perform systematic analyses of the surface roughness of other celestial bodies. [less ▲]

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See detailPest regulation and support of natural enemies in agriculture: Experimental evidence of within field wildflower strips
Hatt, Séverin ULg; Chevalier Mendes Lopes, Thomas ULg; Boeraeve, Fanny ULg et al

in Ecological Engineering (2017), 98

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for ... [more ▼]

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for today’sagriculture. The aim of this study was to assess whether the two strategies of complicating the search ofhost plants by pests by increasing plant diversity, and of supporting their natural enemies by managinghabitats, could be combined simultaneously at the field scale to restore biological pest control and reducechemical insecticide use. In Gembloux (Belgium), wildflower strips (WFS) were sown within wheat cropsin which pests (i.e., aphids), their predators (i.e. aphidophagous hoverflies, lacewings and ladybeetles)and parasitoid wasps were monitored for 10 weeks in the period of May through July 2015 as indicatorsof the ES of pest control. Aphids were significantly reduced and adult hoverflies favoured in wheat inbetween WFS, compared to monoculture wheat plots. No significant differences were observed for adultlacewings, ladybeetles and parasitoids. In all treatments, very few lacewing and ladybeetle larvae wereobserved on wheat tillers. The abundance of hoverfly larvae was positively correlated with the aphid den-sity on tillers in between WFS, showing that increasing food provisions by multiplying habitats withinfields, and not only along margins, can help supporting aphidophagous hoverflies in crops. By enhancingthe ecosystem services of biological pest control, this study shows that increasing both plant diversityand managing habitats for natural enemies may reduce aphid populations, hence insecticide use. Futureresearch should continue this vein of work by quantifying the link between agricultural practices and thedelivery of ecosystem services in order to guide future measures of agricultural policies. [less ▲]

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See detailEstrogen receptors and estetroldependent neuroprotective actions: a pilot study
Tskitishvili, Ekaterine ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Journal of Endocrinology (2017), 232(1), 85-95

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic–ischemic encephalopathy. We aimed to define the role of estrogen ... [more ▼]

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic–ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/ proliferating effects of E4 on H2O2-induced oxidative stress in primary hippocampal cell cultures were studied using different combinations of specific inhibitors for ERα (MPP dihydrochloride), ERβ (PHTTP), GPR30 (G15) and palmytoilation (2-BR). LDH activity and cell survival assays were performed. In vivo the promyelinating role of different concentrations of E4 (1mg/kg/day, 5mg/kg/day, 10mg/kg/day, 50mg/kg/day) was investigated using the hypoxic–ischemic brain damage model in the 7-day-old immature rats before/after the induction of hypoxic–ischemic insult. Myelin basic protein (MBP) immunostaining was performed on brain coronal sections. Our results show that LDH activity is significantly upregulated in cell cultures where the E4’s effect was completely blocked by concomitant treatment either with ERα and ERβ inhibitors (MPP and PHTPP, respectively), or ERα and ERβ inhibitors combined with 2-BR. Cell survival is significantly downregulated in cell cultures where the effect of E4 was blocked by ERβ inhibitor (PHTTP) alone. The blockage of GRP30 receptor did affect neither LDH activity nor cell survival. MBP immunostaining is significantly upregulated in E4-pretreated groups at a concentration of 5mg/kg/day and 50mg/kg/day E4, whereas the MBP-positive area OD ratio is significantly increased in all the E4-treated groups. E4’s antioxidative actions mostly depend on ERα and ERβ, whereas neurogenesis and possibly promyelinating activities might be realized through ERβ. [less ▲]

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See detailNonlinear system identification in structural dynamics: 10 more years of progress
Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Mechanical Systems & Signal Processing (2017), 83

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved ... [more ▼]

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved until then, it was concluded that the identification of simple continuous structures with localised nonlinearities was within reach. The past decade witnessed a shift in emphasis, accommodating the growing industrial need for a first generation of tools capable of addressing complex nonlinearities in larger-scale structures. The objective of the present paper is to survey the key developments which arose in the field since 2006, and to illustrate state-of-the-art techniques using a real-world satellite structure. Finally, a broader perspective to nonlinear system identification is provided by discussing the central role played by experimental models in the design cycle of engineering structures. [less ▲]

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See detailSartre in Venedig: der Mann, der in die Kälte ging
Cormann, Grégory ULg; Viehöver, Vera ULg

in Bulletin d'Analyse Phénoménologique (2017), 11

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See detailFacies discrimination with ERT using a probabilistic methodology: effect of sensitivity and regularization
Hermans, Thomas ULg; Irving, James

in Near Surface Geophysics (2017), 15

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution ... [more ▼]

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution of facies. However, inverted ERT images tend to be grossly smoothed versions of reality because of the regularization of the inverse problem. In this study, we use a probabilistic methodology based upon co-located measurements to assess the utility of ERT to identify hydrofacies in alluvial aquifers. With this methodology, ERT images are interpreted in terms of the probability of belonging to pre-defined hydrofacies. We first analyze through a synthetic study the ability of ERT to discriminate between different facies. As ERT data suffer from a loss of sensitivity with depth, we find that low sensitivity regions are more affected by misclassification. To counteract this effect, we adapt the probabilistic framework to include the spatially varying data sensitivity. We then apply our learning to a field case. For the latter, we consider two different regularization procedures. In contrast to the data sensitivity which affects the facies probability to a limited amount, the regularization can affect the probability maps more considerably because it has a strong influence on the spatial distribution of inverted resistivity. We find that a regularization strategy based on the most realistic prior information tends to offer the most reliable discrimination of facies. Our results confirm the ability of ERT surveys, when properly designed, to detect facies variations in alluvial aquifers. The method can be easily extended to other contexts. [less ▲]

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See detailExperimental observation of the Poincaré-Birkhoff scenario in a driven many-body quantum system
Tomkovic, Jiri; Muessel, Wolfgang; Strobel, Helmut et al

in Physical Review A (2017), 95

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See detailOn the evaluation of interface quality in concrete repair system by means of impact-echo signal analysis
Garbacz, Andrzej; Piotrowski, Tomacz; Courard, Luc ULg et al

in Construction and Building Materials (2017), 134

According to Concrete Repair Manual as well as ACI 562-16 and European EN 1504-10 standards, a bond strength as a measure of adhesion is one the main feature of repair system necessary to be assessed. The ... [more ▼]

According to Concrete Repair Manual as well as ACI 562-16 and European EN 1504-10 standards, a bond strength as a measure of adhesion is one the main feature of repair system necessary to be assessed. The most common laboratory and engineering method for bond strength evaluation is pull-off test. This is however a semi-destructive method that needs a repair in a place of measurement. Recently, the great interest in nondestructive techniques (NDT) development is noted. Impact-Echo (IE) is considered as one of the most promising methods for this purpose. In this paper, the study on the usability the IE test based on frequency spectrum analysis for bond strength evaluation is analyzed. Both Finite Element Method (FEM) simulation and experimental tests were performed in order to obtain potential relations between IE frequency spectrum and parameters characterizing concrete substrate quality that may affect the final bond strength and the real value of pull-off bond strength measured on samples as well. It was concluded that the IE method can be a useful tool for interface quality and bond strength evaluations in concrete repair system. However, more complex signal analysis, e.g. wavelet analysis, should be considered in the future. [less ▲]

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See detailMacroevolution of Specificity in Cyanolichens of the Genus Peltigera Section Polydactylon (Lecanoromycetes, Ascomycota)
Magain, Nicolas ULg; Miadlikoswka, Jolanta; Goffinet, Bernard et al

in Systematic Biology (2017), 66(1), 74-99

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See detailPest and mould infestation of smoked shrimp and preventive measures for storage in cottage industry
Kpoclou; Anihouvi; Azokpota et al

in Indian Journal of Traditional Knowledge (2017), 16

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See detailEffects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study
Gaul, Charly; MAGIS, Delphine ULg; Liebler, Eric et al

in Journal of Headache and Pain (2017), 18

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve ... [more ▼]

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study. Findings: After a 2-week baseline phase, 97 patients with chronic cluster headache entered a 4-week randomised phase to receive nVNS + SoC (n = 48) or SoC alone (n = 49). All 92 patients who continued into a 4-week extension phase received nVNS + SoC. Compared with SoC alone, nVNS + SoC led to a significantly lower mean weekly attack frequency by week 2 of the randomised phase; the attack frequency remained significantly lower in the nVNS + SoC group through week 3 of the extension phase (P < 0.02). Attack frequencies in the nVNS + SoC group were significantly lower at all study time points than they were at baseline (P < 0.05). Response rates were significantly greater with nVNS + SoC than with SoC alone when response was defined as attack frequency reductions of ≥25%, ≥50%, and ≥75% from baseline (≥25% and ≥50%, P < 0.001; ≥75%, P = 0.009). The 100% response rate was 8% with nVNS + SoC and 0% with SoC alone. Conclusions: Prophylactic nVNS led to rapid, significant, and sustained reductions in chronic cluster headache attack frequency within 2 weeks after its addition to SoC and was associated with significantly higher ≥25%, ≥50%, and ≥75% response rates than SoC alone. The rapid decrease in weekly attack frequency justifies a 4-week trial period to identify responders to nVNS, with a high degree of confidence, among patients with chronic cluster headache. [less ▲]

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See detailThiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stressinduced behaviours in mice
Markova, Nataliia; Bazhenova, Nataliya; Anthony, Daniel C et al

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (2017), 75

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling ... [more ▼]

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling the activities of glycogen synthase kinase (GSK)-3β. While decreased GSK- 3β activity appears to impair memory, increased GSK-3β activity is associated with the distressed/depressed state. However, direct evidence for the effects of thiamine on GSK-3β function were not have not been reported. Here, we administered thiamine or, the more bioavailable precursor, benfotiamine at 200 mg/kg/day for 2 weeks to C57BL/6J mice, to determine whether treatment might affect behaviours that are known to be sensitive to GSK-3β activity and whether such administration impacts on GSK-3β expression within the brain. The mice were tested in models of contextual conditioning and extinction, a 5-day rat exposure stress test, and a modified swim test with repeated testing. Imipramine (7.5 mg/kg/day) was administered as a positive control for thiamine or benfotiamine. As for imipramine, both compounds inhibited the upregulation of GSK-3β induced by predator stress or repeated swimming, and reduced floating scores and the predator stress-induced behavioural changes in anxiety and exploration. Coincident, thiamine and benfotiamine improved learning and extinction of contextual fear, and the acquisition of the step-down avoidance task. Together, our data indicate that thiamine and benfotiamine have antidepressant/anti-stress effects in naïve animals that are associated with reduced GSK-3β expression. Importantly, the treatment also had pro-cognitive actions despite the impact on GSK-3β activity. [less ▲]

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See detailObservations of asymmetric turbulent stirring in inner and marginal seas using satellite imagery
Karimova, Svetlana ULg

in International Journal of Remote Sensing (2017), 38(6), 1642-1664

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale ... [more ▼]

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale cyclonic and anticyclonic eddies in a number of inner and marginal marine basins, namely in the Baltic, Black, North, and Western Mediterranean Seas. As research material, over 9700 eddy manifestations in the thermal infrared, visible-range, and radar satellite imagery were used. The analysis performed showed that in all the seas the typical and average values of the diameter of anticyclonic eddies were greater than those of cyclonic eddies. The main factor that defines the ratio between anticyclonic and cyclonic eddies in the basins under consideration was discovered to be the intensity of their surface currents. Thus, in the presence of a strong jet flow at the scales of about 2–4 baroclinic Rossby radii the cyclonic eddy dominance typical for smaller eddies was replaced by the anticyclonic one. If strong jet streams were missing, as that typical of the Baltic Sea, cyclonic eddies were prevailing over the entire spectrum of eddy diameters. [less ▲]

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See detailWalnut husk fly, Rhagoletis completa (Diptera: Tephritidae), invades Europe: invasion potential and control strategies
Verheggen, François ULg; Verhaeghe, Agnès; Giordanengo, Philippe et al

in Applied Entomology and Zoology (2017), 52(1), 1-7

Rhagoletis completa Cresson (Diptera: Tephritidae) is native to North America and invaded Western Europe in the late 1980s, causing important damage to its principal host, walnut (Juglans spp.). In this ... [more ▼]

Rhagoletis completa Cresson (Diptera: Tephritidae) is native to North America and invaded Western Europe in the late 1980s, causing important damage to its principal host, walnut (Juglans spp.). In this review, we summarize the important elements of R. completa’s biology, phytosanitary status and methods used in Europe for its control, and then present the main conclusions associated with a completed risk analysis performed in 2014 to evaluate the dispersion and establishment potential of R. completa in Europe. The walnut husk fly was initially identified in Switzerland (1988) and Italy (1991), from where it spread to at least seven additional countries: France, Spain, Germany, Austria, Croatia, Slovenia and Hungary. R. completa has not reached the limits of its potential distribution. The main dissemination pathways within Europe include: (1) natural adult dissemination; (2) adult hitchhiker behaviour; and, to a lesser extent, (3) transportation of larvae in fresh fruits. R. completa host plants are widely distributed in Europe, either as isolated wild trees or in orchards, favouring the probability of fly establishment in currently fly-free areas. In addition, the European territories where Juglans species are present share biogeographic similarities. In orchards where R. completa is present and uncontrolled, 100% of walnut trees can be infested, causing losses in walnut yields of up to 80%. The negative effect is low (<10% yield loss) under phytosanitary control, although additional costs must also be considered to support specific monitoring for R. completa. The information presented here underlines a strong need for better walnut husk fly monitoring across European countries, as well as for increasing efforts to develop biological methods to control this emerging pest. [less ▲]

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See detailAre Th17 Cells Playing a Role in Immunity to Dermatophytosis?
Heinen, Marie-Pierre ULg; Cambier, Ludivine ULg; Fievez, Laurence ULg et al

in Mycopathologia (2017), 182(1), 251-261

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See detailThe role of parental anxiety sensitivity and learning experiences in children's anxiety sensitivity.
Stassart, Céline ULg; Dardenne, Benoît ULg; Etienne, Anne-Marie ULg

in British Journal of Developmental Psychology (2017)

This study evaluated the impact of the mother’s and father’s anxiety sensitivity (AS) andlearning experiences on children’s AS, and the influence of two moderators: the children’sfemininity orientation and ... [more ▼]

This study evaluated the impact of the mother’s and father’s anxiety sensitivity (AS) andlearning experiences on children’s AS, and the influence of two moderators: the children’sfemininity orientation and the children’s emotional intelligence (EI). The samplecomprised 200 non-clinical children, aged 9–13 years, and their parents (mothers andfathers). Results revealed that the effect of parental AS on children’s AS is moderated bythe children’s EI for maternal AS and by their femininity traits for paternal AS. Learningexperiences following somatic sensations influenced the children’s level of AS. Morespecifically, special attention by parents following a child’s somatic sensations (reinforce-ment and transmission of information) was associated with high AS in children. Parentalreactions of fear following a parent’s somatic sensations (modelling) seem to predicthigher scores for AS when the link is moderated by the child’s femininity orientation. Theimplications of these findings are discussed. [less ▲]

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See detailImpact of pollen resources drift on common bumblebees in NW Europe
Roger, N.; Moerman, R.; Carvalheiro, L. G. et al

in Global Change Biology (2017), 23(1), 68-76

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant ... [more ▼]

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant abundance and quality. Here, we investigate whether generalist bumblebee species, with stable population trends over the past years, adapted their diets in response to changes in the distribution and chemical quality of their pollen resources. We selected five common species of bumblebee in NW Europe for which we had a precise description of their pollen diet through two time periods (‘prior to 1950’ and ‘2004–2005’). For each species, we assessed whether the shift in their pollen diet was related with the changes in the suitable area of their pollen resources. Concurrently, we evaluated whether the chemical composition of pollen resources changed over time and experimentally tested the impact of new major pollen species on the development of B. terrestris microcolonies. Only one species (i.e. B. lapidarius) significantly included more pollen from resources whose suitable area expanded. This opportunist pattern could partly explain the expansion of B. lapidarius in Europe. Regarding the temporal variation in the chemical composition of the pollen diet, total and essential amino acid contents did not differ significantly between the two time periods while we found significant differences among plant species. This result is driven by the great diversity of resources used by bumblebee species in both periods. Our bioassay revealed that the shift to new major pollen resources allowed microcolonies to develop, bringing new evidence on the opportunist feature of bumblebee in their diets. Overall, this study shows that the response to pollen resource drift varies among closely related pollinators, and a species-rich plant community ensures generalist species to select a nutrient-rich pollen diet. © 2016 John Wiley & Sons Ltd [less ▲]

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See detailGenomic Studies of Multiple Myeloma Reveal an Association between X Chromosome Alterations and Genomic Profile Complexity.
Sticca, Tiberio ULg; CABERG, Jean-Hubert ULg; Wenric, Stéphane ULg et al

in Genes, Chromosomes & Cancer (2017)

The genomic profile of multiple myeloma (MM) has prognostic value by dividing patients into a good prognosis hyperdiploid group and a bad prognosis non-hyperdiploid group with a higher incidence of IgH ... [more ▼]

The genomic profile of multiple myeloma (MM) has prognostic value by dividing patients into a good prognosis hyperdiploid group and a bad prognosis non-hyperdiploid group with a higher incidence of IgH translocations. This classification, however, is inadequate and many other parameters like mutations, epigenetic modifications and genomic heterogeneity may influence the prognosis. We performed a genomic study by array-based comparative genomic hybridization (aCGH) on a cohort of 162 patients to evaluate the frequency of genomic gains and losses. We identified a high frequency of X chromosome alterations leading to partial Xq duplication, often associated with Xi deletion in female patients. This partial X duplication could be a cytogenetic marker of aneuploidy as it is correlated with a high number of chromosomal breakages. Patient with high level of chromosomal breakage had reduced survival regardless the region implicated. A higher transcriptional level was shown for genes with potential implication in cancer and located in this altered region. Among these genes, IKBKG and IRAK1 are members of the NFKB pathway which plays an important role in MM and is a target for specific treatments. [less ▲]

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See detailFamilial history of migraine influences habituation of visual evoked potentials
Lisicki Martinez, Marco ULg; Ruiz-Romagnoli, Emiliano; D'Ostilio, Kevin ULg et al

in Cephalalgia : An International Journal of Headache (2017)

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation ... [more ▼]

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation pattern associated with migraine. The aim of this study was to evaluate the influence of a positive familial history of migraine on VEP amplitude and habituation. Methods: We recorded six blocks of 100 VEP during continuous pattern-reversal stimulation in 30 patients with migraine between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree relative suffering from migraine (HVm) and 15 had not (HV). Results: Both MO and HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 first block amplitudes, compared to HV (habituation slope: MO ¼ 0.033, HVm ¼ 0.021, HV ¼ 0.025, HV vs. MO p ¼ 0.002, HV vs. HVm p ¼ 0.036; mean N1-P1 amplitude in the first block: MO ¼ 9.08 mV, HVm ¼ 9.29 mV, HV ¼ 12.19 mV. HV vs. MO p ¼ 0.041, HV vs. HVm p ¼ 0.076). The first block N1-P1 amplitude was negatively correlated with the habituation slope for both MO (r ¼ .44, p ¼ 0.015) and HVm (r ¼ .56, p ¼ 0.031) while no significant correlation was found in HV (r ¼ .17, p ¼ 0.53). There were no differences in VEP latencies between the groups. Conclusions: Our study suggests that lack of habituation of visual evoked potentials is probably a genetically determined endophenotypic trait that is associated with both migraine and migraine susceptibility. We hypothesize that genetic diversity of populations could account for some of the discrepancies between electrophysiological studies performed in migraine and for interindividual variations among the subgroups. [less ▲]

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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailCabergoline for Cushing's disease: a large retrospective multicenter study.
Ferriere, A.; Cortet, C.; Chanson, P. et al

in European Journal of Endocrinology (2017), 176(3), 305-314

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of ... [more ▼]

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received cabergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism and adverse effects were recorded. RESULTS: Twenty-one (40%) of 53 patients who received cabergoline monotherapy had normal urinary free cortisol (UFC) values within 12 months (complete responders), and five of these patients developed corticotropic insufficiency. The fall in UFC was associated with significant reductions in midnight cortisol and plasma ACTH, and with clinical improvement. Compared to other patients, complete responders had similar median baseline UFC (2.0 vs 2.5xULN) and plasma prolactin concentrations but received lower doses of cabergoline (1.5 vs 3.5 mg/week, P < 0.05). During long-term treatment (>12 months), cabergoline was withdrawn in 28% of complete responders because of treatment escape or intolerance. Overall, sustained control of hypercortisolism was obtained in 23% of patients for 32.5 months (19-105). Nine patients on steroidogenesis inhibitors received cabergoline add-on therapy for 19 months (1-240). Hypercortisolism was controlled in 56% of these patients during the first year of treatment with cabergoline at 1.0 mg/week (0.5-3.5). CONCLUSIONS: About 20-25% of CD patients are good responders to cabergoline therapy allowing long-term control of hypercortisolism at relatively low dosages and with acceptable tolerability. No single parameter, including the baseline UFC and prolactin levels, predicted the response to cabergoline. [less ▲]

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See detailIntegrating production scheduling and vehicle routing decisions at the operational decision level: A review and discussion
Moons, Stef; Ramaekers, Katrien; Caris, An et al

in Computers & Industrial Engineering (2017), 104

Production scheduling and vehicle routing are two well-studied problems in literature. Although these supply chain functions are interrelated, they are often solved sequentially. This uncoordinated ... [more ▼]

Production scheduling and vehicle routing are two well-studied problems in literature. Although these supply chain functions are interrelated, they are often solved sequentially. This uncoordinated approach can lead to suboptimal solutions. In the current competitive business environment, companies are searching for methods to save costs and improve their service level. Integrating production and distribution scheduling operations can be an approach to improve the overall performance. This paper focuses on integrated production-distribution operational level scheduling problems, which explicitly take into account vehicle routing decisions of the delivery process. Existing literature on integrated production scheduling and vehicle routing problems is reviewed and classified. Both the problem characteristics of mathematical models and the accompanying solution approaches are discussed to identify directions for further research. [less ▲]

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See detailEvaluation of hazardous chemicals in edible insects and insect-based food intended for human consumption
Poma, G; Cuykx, M; Amato, E et al

in Food and Chemical Toxicology (2017), 100

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See detailInfluence of the crustal magnetic field on the Mars aurora electron flux and UV brightness
Bisikalo, D. V.; Shematovich, V. I.; Gérard, Jean-Claude ULg et al

in Icarus (2017), 282

Observations with the SPICAM instrument on board Mars Express have shown the occasional presence of localized ultraviolet nightside emissions associated with enhanced energetic electron fluxes. These ... [more ▼]

Observations with the SPICAM instrument on board Mars Express have shown the occasional presence of localized ultraviolet nightside emissions associated with enhanced energetic electron fluxes. These features generally occur in regions with significant radial crustal magnetic field. We use a Monte-Carlo electron transport model to investigate the role of the magnetic field on the downward and upward electron fluxes, the brightness and the emitted power of auroral emissions. Simulations based on an ASPERA-3 measured auroral electron precipitation indicate that magnetic mirroring leads to an intensification of the energy flux carried by upward moving electrons- from about 20% in the absence of crustal magnetic field up to 33-78% when magnetic field is included depending on magnetic field topology. Conservation of the particle flux in a flux tube implies that the presence of the B-field does not appreciably modify the emission rate profiles for an initially isotropic pitch angle distribution. However, we find that crustal magnetic field results in increase of the upward electron flux, and, consequently, in reduction of the total auroral brightness for given energy flux of precipitating electrons. [less ▲]

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See detailContinuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination.
Thiry, Justine ULg; Lebrun, Pierre; Vinassa, Chloé et al

in International Journal of Pharmaceutics (2016), 515(1-2), 114-124

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See detailIs Competence a Holy Grail for Teaching? Reflections on Nursing Education
Dancot, Jacinthe ULg

in Nursing & Care Open Access Journal (2016), 1(4), 00021

The competence-based approach is largely widespread in the nursing schools and is viewed as a golden standard for professional teaching. But the practical use of the concept is varying among institutions ... [more ▼]

The competence-based approach is largely widespread in the nursing schools and is viewed as a golden standard for professional teaching. But the practical use of the concept is varying among institutions and even teachers. The goal of this narrative review is to clarify the conception of competence and its use in the fields of education and nursing. Regarding education, Gonczi, Tardif, Jonnaert and Beckers are the key authors referred to. A first apparent consensus over the holistic nature of the competence quickly gives place to the observation of important nuances in conceptions. Similarly, in the field of nursing, Benner is first discussed, and recent literature reviews and concept analyses are taken into account: similar nuances are detected, as well as difficulties in the practical implementation of the concept. Considering the lack of consensus and the paradigmaticalincoherences detected among the sources consulted for this review, we question the use of competence as single point of view for teaching and assessing, and we propose other avenues to be explored in order to recognize emergent professionality. [less ▲]

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See detailComprehension of an organosolv process for lignin extraction on Festuca arundinacea and monitoring of the cellulose degradation
Schmetz, Quentin ULg; Maniet, Guillaume ULg; Jacquet, Nicolas ULg et al

in Industrial Crops and Products (2016), 94

It is commonly accepted that the current society needs to partially substitute fossil resources by renewable ones. Among many solutions, one approach consists in the development of biorefinery involving ... [more ▼]

It is commonly accepted that the current society needs to partially substitute fossil resources by renewable ones. Among many solutions, one approach consists in the development of biorefinery involving lignocellulosic biomass to produce bio-based materials and fuels. This study focuses on the comprehension of an organosolv treatment designed to break the complex lignocellulosic structure for high purity lignin extraction from tall fescue (Festuca arundinacea Schreb.). This grass benefits from an increasing interest in Western Europe and has been suggested as feedstock for biorefinery. However, its use as material for high purity lignin production has not been determined yet. Ethanol/water, 92/8% [v/v] with H2SO4 0.32 M was investigated at pilot scale under conventional heating (5 °C min−1 during 30 min and stabilized at 148 °C for 5 min). Precipitated lignin were analyzed as well as the composition of side-stream products (recovered cellulosic pulp and the aqueous hydrolysate). Lignin has been recovered at a purity level of 90% with a yield of 60%. The main contaminants were nitrogen containing compounds and degraded hemicelluloses. 2D-HSQC NMR (Two Dimension-Heteronuclear Single Quantum Correlation Nuclear Magnetic Resonance) revealed a co-extraction of ferulates and coumarates function as well as arabinoxylan. Cellulose was recovered at 53% purity with 60% yield. The conditions appear to be too harsh for tall fescue and led to significant amount of cellulose degradation. A process using a lower alcohol concentration will be developed to provide better yields of both cellulose and lignin. [less ▲]

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See detailInterpellation du genre et sujets mélancoliques. Butler lectrice d’Althusser
Borotto, Jessica ULg

in Cahiers du GRM (2016), 8

Cet article propose d’explorer la manière dont Judith Butler remobilise la thèse althussérienne de l’interpellation dans La Vie psychique du pouvoir . Nous essaierons de saisir les éléments qui nous ... [more ▼]

Cet article propose d’explorer la manière dont Judith Butler remobilise la thèse althussérienne de l’interpellation dans La Vie psychique du pouvoir . Nous essaierons de saisir les éléments qui nous paraissent enrichir la problématique althussérienne, suggérant que la compréhension de la dimension psychique du pouvoir qui ressort de sa lecture permet de complexifier la relation du sujet au pouvoir. Afin de tisser des liens précis entre l’interpellation chez Althusser et la subjectivation chez Butler, nous examinerons d’abord le rôle que Nietzsche et Foucault recouvrent dans la formulation de la théorie de la subjectivation chez Butler. Ensuite, il s’agit de comprendre en quoi la matérialité et l’ambiguïté des mécanismes de subjectivation, qui déjà caractérisent l’interpellation althussérienne, deviennent chez Butler les sources d’une relation critique aux conditions d’émergence du sujet. Enfin nous préciserons comment elle mobilise de telles sources pour élaborer cette figure de la psychanalyse qu’est la mélancolie et pour décrire sa transformation en deuil. [less ▲]

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See detailLearning from Incidents and Incident Reporting: Safety Governance at a Belgian Nuclear Research Center
Rossignol, Nicolas ULg; Van Oudheusden, Michiel ULg

in Science, Technology & Human Values (2016), Online First

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews ... [more ▼]

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews and focus groups with personnel, it illustrates how REX enacts a safety governmentality centered on identifying incident causes and culprits. As this governmentality mode obscures the epistemic and political character of incidents, it closes down important opportunities for collective learning about safety and safety governance. It is argued that joint reflection about incidents and resistances towards incident reporting serve as fruitful starting points for a more reflexive safety governance that makes explicit how decisions are made in high-risk contexts. Social scientists can enhance governance of this kind by pointing to different perceptions and evaluations of incidents and by insisting that contending interpretations are confronted and accounted for. [less ▲]

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See detailScreening transplant donors for HTLV-1 and -2
Gallo, Robert; Willems, Luc ULg; Hasegawa, 4 Hideki et al

in Blood (2016), 128(26),

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See detailSU(3) flavor symmetry breaking in large $N_c$ excited baryons
Stancu, Floarea ULg

in Physical Review. D : Particles and Fields (2016), 94

The $1/N_c$ expansion method for studying the mass spectrum of excited baryons is shortly reviewed together with applications to mixed symmetric states. The $[{\bf 70, \ell^+}]$ multiplet, belonging to ... [more ▼]

The $1/N_c$ expansion method for studying the mass spectrum of excited baryons is shortly reviewed together with applications to mixed symmetric states. The $[{\bf 70, \ell^+}]$ multiplet, belonging to the $N$ = 2 band, is reanalyzed, with emphasis on hyperons and the SU(3) symmetry breaking operators entering the mass formula to first order. An important result is that the hierarchy of masses as a function of strangeness is correctly reproduced for all multiplets. Predictions for unknown excited hyperons to SU(6) $\times$ O(3) multiplets are made. [less ▲]

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See detailEffect of the Extraction Technique, Heating Time and Cryogenic Grinding (N2 at -196°C) on the Composition of Cumin Seeds Volatile Oil
Mékaoui, R; Benkaci-Ali, Farid; Scholl, Georges ULg et al

in Journal of Essential Oil-Bearing Plants [=JEOBP] (2016), 19(8), 1903-1919

Two techniques of extraction of essential oils (Steam distillation assisted by microwave (SDAM) and hydrodistillation assisted by microwave (HDAM)) are respectively advanced steam distillation (SD) and ... [more ▼]

Two techniques of extraction of essential oils (Steam distillation assisted by microwave (SDAM) and hydrodistillation assisted by microwave (HDAM)) are respectively advanced steam distillation (SD) and hydrodistillation techniques (HD), in which a microwave oven is used in the extraction process. They are considered as accelerated techniques extraction performed at atmospheric pressure. The cryogrinding (CG) showed a difference on the yields and aromatic profile comparing to the sample grinding. Isolation and concentration of volatile compounds are performed by a single stage for the extraction of volatile oil from Algerian (Sahara) Cuminum cyminum seeds (CCS). The chemical composition of the essential oil of this plant as a function of extraction time was also studied. The major components and family classes showed a significant variation with the extraction time. Gas chromatography (GC), GCxGC-mass spectrometry (GCxGC-MS)] were utilised for qualitative and quantitative analysis of essential oils extracted by these two methods. The major compounds are cumin aldehyde (HDAM-CG: 20.50-53.35 %, SDAM-CG: 21.68 66.6 %), p-cymene (HDAM-CG: 14.1-37.54 %, SDAM-CG: 6.06-20.18 %), β-pinene (HDAM-CG: 4.53-14.74 %, SDAM-CG: 4.3-32.65 %) and γ-terpinene (HDAM-CG: 1.26-14.70 %, SDAM-CG: 5.13-18.23 %). [less ▲]

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See detailEditorial
Borotto, Jessica ULg; Petteni, Oriane ULg; Wustefeld, Sophie ULg et al

in Cahiers du GRM (2016), 10

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See detailLa SNCB : prête pour la libéralisation totale du rail ?
Gautier, Axel ULg; Salem, Iman

in Regards Economiques (2016)

La SNCB n’a pas su s’adapter à la libéralisation du fret ferroviaire faute de rentabilité. Dans la perspective d’une libéralisation du transport de passagers annoncée pour 2023, nous évaluons les ... [more ▼]

La SNCB n’a pas su s’adapter à la libéralisation du fret ferroviaire faute de rentabilité. Dans la perspective d’une libéralisation du transport de passagers annoncée pour 2023, nous évaluons les performances de l’entreprise. Notre étude met en avant un déficit de productivité et une contribution faible des passagers aux coûts par rapport à d’autres opérateurs européens. [less ▲]

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See detailNew data on the incertae sedis biota and foraminifera of the mid-Famennian Baelen Member (Late Devonian, eastern Belgium)
Vachard, Daniel; Dreesen, Roland; Mottequin, Bernard et al

in Paleobiodiversity and Paleoenvironments (2016), 21

The Baelen mud mounds in eastern Belgium represent a local member of the mid-Famennian Souverain-Pré Formation (an important carbonate interval within the Condroz Sandstone Group). The lower part of this ... [more ▼]

The Baelen mud mounds in eastern Belgium represent a local member of the mid-Famennian Souverain-Pré Formation (an important carbonate interval within the Condroz Sandstone Group). The lower part of this member contains silty bioclastic wackestones and packstones that are particularly rich in the problematical algae Serrisinella and Dreesenullella. Plurilocular foraminifera (Septabrunsiina and Baelenia) and rare solitary rugose corals (Neaxon? sp.) occur within crinoidal grainstones (tempestites) interfingering with the latter bioclastic wacke-/packstones and red-stained stromatactoid spiculitic mudstones (carbonate mound core facies). Although Serrisinella is quite common in other mid- and late Famennian limestones, of Belgium, Dreesenulella is almost endemic of the Baelen Member. Both genera apparently inhabited the muddy sediment-water interface, constituting meadows probably in zones of intermittently strong bottom currents. The taxonomic similarities between Dreesenulella and Saccamminopsis are discussed, as well as their possible affinities with the Xenophophyrea and Kokomiacea. Moreover, the first stages of the Septabrunsiina–Baelenia foraminiferal lineage are analysed in detail. The taxonomic and palaoecological positioning of Serrissinella and Dreesenulella adds to the discussion about the palaeobathymetry of the Baelen mud mounds and corroborates sedimentological evidence for their relatively shallow carbonate ramp depositional setting. [less ▲]

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See detailModel Sensitivity Studies of the Decrease in Atmospheric Carbon Tetrachloride
Chipperfield, M. P.; Liang, Q.; Rigby, M. et al

in Atmospheric Chemistry and Physics (2016), 16

Carbon tetrachloride is an ozone-depleting substance, which is controlled by the Montreal Protocol and for which the atmospheric abundance is decreasing. However, the current observed rate of this ... [more ▼]

Carbon tetrachloride is an ozone-depleting substance, which is controlled by the Montreal Protocol and for which the atmospheric abundance is decreasing. However, the current observed rate of this decrease is known to be slower than expected based on reported CCl4 emissions and its estimated overall atmospheric lifetime. Here we use a three-dimensional (3-D) chemical transport model to investigate the impact on its predicted decay of uncertainties in the rates at which CCl4 is removed from the atmosphere by photolysis, by ocean uptake and by degradation in soils. The largest sink is atmospheric photolysis (76% of total) but a reported 10% uncertainty in its combined photolysis cross-section and quantum yield has only a modest impact on the modelled rate of CCl4 decay. This is partly due to the limiting effect of the rate of transport of CCl4 from the main tropospheric reservoir to the stratosphere where photolytic loss occurs. The model suggests large interannual variability in the magnitude of this stratospheric photolysis sink caused by variations in transport. The impact of uncertainty in the minor soil sink (9% of total) is also relatively small. In contrast, the model shows that uncertainty in ocean loss (15% of total) has the largest impact on modelled CCl4 decay due to its sizeable contribution to CCl4 loss and large uncertainty range (157 to 313 years). With an assumed CCl4 emission rate of 39 Gg/yr, the reference simulation with best estimate of loss processes still underestimates the observed CCl4 (overestimates the decay) over the past two decades but to a smaller extent than previous studies. Changes to the rate of CCl4 loss processes, in line with known uncertainties, could bring the model into agreement with in situ surface and remote-sensing measurements, as could an increase in emissions to around 45 Gg/yr. Further progress in constraining the CCl4 budget is partly limited by systematic biases between observational datasets. For example, surface observations from the NOAA network are larger than from the AGAGE network but have shown a steeper decreasing trend over the past two decades. These differences imply a difference in emissions which is significant relative to uncertainties in the magnitudes of the CCl4 sinks. [less ▲]

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See detailInsights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
CHARLIER, Edith ULg; RELIC, Biserka ULg; Deroyer, Céline ULg et al

in International Journal of Molecular Sciences (2016)

Abstract: Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms. Compelling studies report the presence of ... [more ▼]

Abstract: Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms. Compelling studies report the presence of empty lacunae and hypocellularity in cartilage with aging and OA progression, suggesting that chondrocyte cell death occurs and participates to OA development. However, the relative contribution of apoptosis per se in OA pathogenesis appears complex to evaluate. Indeed, depending on technical approaches, OA stages, cartilage layers, animal models, as well as in vivo or in vitro experiments, the percentage of apoptosis and cell death types can vary. Apoptosis, chondroptosis, necrosis, and autophagic cell death are described in this review. The question of cell death causality in OA progression is also addressed, as well as the molecular pathways leading to cell death in response to the following inducers: Fas, Interleukin-1 (IL-1 ), Tumor Necrosis factor- (TNF- ), leptin, nitric oxide (NO) donors, and mechanical stresses. Furthermore, the protective role of autophagy in chondrocytes is highlighted, as well as its decline during OA progression, enhancing chondrocyte cell death; the transition being mainly controlled by HIF-1 /HIF-2 imbalance. Finally, we have considered whether interfering in chondrocyte apoptosis or promoting autophagy could constitute therapeutic strategies to impede OA progression. [less ▲]

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See detailCell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus
Poncelet, Luc; Garigliany, Mutien-Marie ULg; Ando et al

in Cell Cycle (Georgetown, Tex.) (2016), 15(24), 3482-3489

The cell cycle-associated neuronal death hypothesis, which has been proposed as a common mechanism for most neurodegenerative diseases, is notably supported by evidencing cell cycle effectors in neurons ... [more ▼]

The cell cycle-associated neuronal death hypothesis, which has been proposed as a common mechanism for most neurodegenerative diseases, is notably supported by evidencing cell cycle effectors in neurons. However, in naturally occurring nervous system diseases, these markers are not expressed in neuron nuclei but in cytoplasmic compartments. In other respects, the Feline Panleukopenia Virus (FPV) is able to complete its cycle in mature brain neurons in the feline species. As a parvovirus, the FPV is strictly dependent on its host cell reaching the cell cycle S phase to start its multiplication. In this retrospective study on the whole brain of 12 cats with naturally-occurring, FPV-associated cerebellar atrophy, VP2 capsid protein expression was detected by immunostaining not only in some brain neuronal nuclei but also in neuronal cytoplasm in 2 cats, suggesting that viral mRNA translation was still occurring. In these cats, double immunostainings demonstrated the expression of cell cycle S phase markers cyclin A, cdk2 and PCNA in neuronal nuclei. Parvoviruses are able to maintain their host cells in S phase by triggering the DNA damage response. S139 phospho H2A1, a key player in the cell cycle arrest, was detected in some neuronal nuclei, supporting that infected neurons were also blocked into the S phase. PCR studies did not support a co-infection with an adeno or herpes virus. ERK1/2 nuclear accumulation was observed in some neurons suggesting that the ERK signaling pathway might be involved as a mechanism driving these neurons far into the cell cycle. [less ▲]

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See detailThe role of AIP mutations in pituitary adenomas: 10 years on
Daly, Adrian ULg; BECKERS, Albert ULg

in Endocrine (2016)

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See detailThe influence of spatially structured soil properties on tree community assemblages at a landscape scale in the tropical forests of southern Cameroon
Vleminckx, Jason; Doucet, Jean-Louis ULg; Morin, Julie ULg et al

in Journal of Ecology (2016)

Species distribution within plant communities results from both the influence of deterministic processes, related to environmental conditions, and neutral processes related to dispersal limitation and ... [more ▼]

Species distribution within plant communities results from both the influence of deterministic processes, related to environmental conditions, and neutral processes related to dispersal limitation and stochastic events, the relative importance of each factor depending on the observation scale. Assessing the relative contribution of environment necessitates controlling for spatial dependences among data points. Recent methods, combining multiple regression and Moran's eigenvectors maps (MEM), have been proved successful in disentangling the influence of pure spatial processes related to dispersal limitation, pure environmental variables (not spatially structured) and spatially structured environmental properties. However, the latter influence is usually not testable when using advanced spatial models like MEM. To overcome this issue, we propose an original approach, based on torus-translations and Moran spectral randomizations, to test the fraction of species abundance variation that is jointly explained by space and seven soil variables, using three environmental and tree species abundance data sets (consisting of 120, 52 and 34 plots of 0·2 ha each, located along 101-, 66- and 35-km-long transect-like inventories, respectively) collected in tropical moist forests in southern Cameroon. The overall abundance of species represented by ≥30 individuals, and 27% of these species taken individually, were significantly explained by fine-scale (<5 km) and/or broad-scale (5–100 km) spatially structured variations in soil nutrient concentrations (essentially the concentration of available Mn, Mg and Ca) along the 120-plots area. The number of significant tests considerably decreased when investigating the two smaller data sets, which mostly resulted from low statistical power rather than weaker floristic and/or edaphic variation captured among plots. Synthesis. Our results provide evidence that tree species turnovers are partly controlled by spatially structured concentrations in soil nutrients at scales ranging from few hundreds of metres to c. 100 km, a poorly documented subject in Central African forests. We also highlight the usefulness of our testing procedure to correctly interpret the space-soil fraction of variation partitioning analyses (which always accounted here for the most important part of the soil contribution), as this fraction was sometimes relatively high (R2 values up to c. 0·3) but nearly or not significant. [less ▲]

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See detailAging of monolithic zirconia dental prostheses: Protocol for a 5-year prospective clinical study using ex vivo analyses
KOENIG, Vinciane ULg; Wulfman, Claudine; DERBANNE, Mathieu et al

in Contemporary Clinical Trials Communication (2016), 4

Background: Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a ... [more ▼]

Background: Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a wellknown problem with zirconia hip prostheses. This phenomenon could be accentuated by masticatory mechanical stress. Until now zirconia LTD process has only been studied in vitro. This work introduces an original protocol to evaluate LTD process of monolithic zirconia prostheses in the oral environment and to study their general clinical behavior, notably in terms of wear. Methods/design: 101 posterior monolithic zirconia tooth elements (molars and premolars) are included in a 5-year prospective clinical trial. On each element, several areas between 1 and 2 mm2 (6 on molars, 4 on premolars) are determined on restoration surface: areas submitted or non-submitted to mastication mechanical stress, glazed or non-glazed. Before prosthesis placement, ex vivo analyses regarding LTD and wear are performed using Raman spectroscopy, SEM imagery and 3D laser profilometry. After placement, restorations are clinically evaluated following criteria of the World Dental Federation (FDI), complemented by the analysis of fracture clinical risk factors. Two independent examiners perform the evaluations. Clinical evaluation and ex vivo analyses are carried out after 6 months and then each year for up to 5 years. Discussion: For clinicians and patients, the results of this trial will justify the use of monolithic zirconia restorations in dental practice. For researchers, the originality of a clinical study including ex vivo analyses of material aging will provide important data regarding zirconia properties. [less ▲]

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See detailLimited Impact of Imatinib in a Murine Model of Sclerodermatouc Chronic Graft-versus-Host Disease
Belle, Ludovic; Fransolet, Gilles ULg; Somja, Joan ULg et al

in PLoS ONE (2016)

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β ... [more ▼]

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β) play a significant role in the fibrosing process occurring in scl-cGVHD. This prompted us to assess the impact of the PDGF-r and c-Abl tyrosine kinase inhibitor imatinib on scl-cGVHD. Methods To assess the impact of imatinib on T cell subset proliferation in vivo, Balb/cJ recipient mice were lethally (7 Gy) irradiated and then injected with 10x106 bone marrow cells from B10.D2 mice on day 0. Fourteen days later, 70x106 carboxyfluorescein succinimidyl ester (CFSE)- labeled splenocytes from B10.D2 mice were infused and imatinib or sterile water was administered for 5 days. To induce severe scl-cGVHD, Balb/cJ mice were injected i.v. with 10.106 bone marrow cells and 70.106 splenocytes from B10.D2 donor mice after 7 Gy irradiation. Mice were then given sterile water or imatinib from day +7 after transplantation to the end of the experiment (day +52). Results Imatinib decreased the proliferation of total T cells (P = 0.02), CD8+ T cells (P = 0.01), and of regulatory T cells (Tregs) (P = 0.02) in the spleen. In the severe scl-cGVHD model, imatinib- treated mice had significantly lower levels of PDGF-r phosphorylation than control mice on day 29 after transplantation (P = 0.008). However, scl-cGVHD scores were similar between vehicle- and imatinib-treated mice during the whole experiment, while there was a suggestion for less weight loss in imatinib-treated mice that reached statistical significance at day +52 following transplantation (P = 0.02). [less ▲]

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See detailIntroduction du Dossier de traduction
Borotto, Jessica ULg; Cavazzini, Andrea

in Cahiers du GRM (2016), 10

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See detailBrisons le système, pouvoir aux femmes ! (Padoue, 1974)
Borotto, Jessica ULg

in Cahiers du GRM (2016), 10

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See detailCorrecting circulation biases in a lower-resolution global general circulation model with data assimilation
Canter, Martin ULg; Barth, Alexander ULg; Beckers, Jean-Marie ULg

in Ocean Dynamics (2016)

In this study, we aim at developing a new method of bias correction using data assimilation. This method is based on the stochastic forcing of a model to correct bias by directly adding an additional ... [more ▼]

In this study, we aim at developing a new method of bias correction using data assimilation. This method is based on the stochastic forcing of a model to correct bias by directly adding an additional source term into the model equations. This method is presented and tested first with a twin experiment on a fully controlled Lorenz ’96 model. It is then applied to the lower-resolution global circulation NEMO-LIM2 model, with both a twin experiment and a real case experiment. Sea surface height observations are used to create a forcing to correct the poorly located and estimated currents. Validation is then performed throughout the use of other variables such as sea surface temperature and salinity. Results show that the method is able to consistently correct part of the model bias. The bias correction term is presented and is consistent with the limitations of the global circulation model causing bias on the oceanic currents. [less ▲]

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See detailRésister à l’essentialisation de l’Allemagne : Les Temps Modernes, revue franco-allemande ?
Franck, Thomas ULg

in Trajectoires (2016), 10

Im Zentrum des vorliegenden Aufsatzes steht die Doppelausgabe (46-47) der französischen Zeitschrift Temps Modernes, die unter dem Titel „Allemagne“ im August-September 1949 erschien und einen besonderen ... [more ▼]

Im Zentrum des vorliegenden Aufsatzes steht die Doppelausgabe (46-47) der französischen Zeitschrift Temps Modernes, die unter dem Titel „Allemagne“ im August-September 1949 erschien und einen besonderen Fall von kulturellem und intellektuellem Transfer zwischen Deutschland und Frankreich darstellt. Mit Mitteln der Diskursanalyse und der Imagologie sollen hier rhetorische Strategien herausgearbeitet werden, die der Realisierung eines kritischen Projekts und der Anprangerung der Stereotypen dienen, die Deutschland damals zugeschrieben wurden. Aufgestellt wird folgende These: Indem sie Intellektuelle aus unterschiedlichen Orten und Disziplinen und heterogenes Wissen zusammenbringt, bietet sich die Zeitschrift besonders gut für eine kritische Reflexion der herrschenden Ideologien und kollektiven Überzeugungen an. Indem es Deutschen mit kommunistischer und antifaschistischer Gesinnung das Wort erteilt, will das Heft „Allemagne“ zu Erkenntnissen über ein ‚anderes Deutschland‘ kommen, das von Aufstand und Widerstand geprägt ist, und bricht so mit einer Reduktion des Landes auf eine unveränderliche und monolithische Identität, die als gleichermaßen fügsam und autoritär verstanden wurde. [less ▲]

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See detailIn vitro evaluation of biocompatibility of uncoated thermally reduced graphene and carbon nanotube-loaded PVDF membranes with adult neural stem cell-derived neurons and glia
Defteralı, Çağla; Verdejo, Raquel; Majeed, Shahid et al

in Frontiers in Bioengineering and Biotechnology (2016), 4(n° 64),

Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were ... [more ▼]

Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were seeded on these materials coated with various proteins implying that the observed effects on the cells could not solely be attributed to the GBN and CNT properties. Here, we studied the biocompatibility of uncoated thermally reduced graphene (TRG) and poly(vinylidene fluoride) (PVDF) membranes loaded with multi-walled CNTs (MWCNTs) using neural stem cells isolated from the adult mouse olfactory bulb (termed aOBSCs). When aOBSCs were induced to differentiate on coverslips treated with TRG or control materials (polyethyleneimine-PEI and polyornithine plus fibronectin- PLO/F) in a serum-free medium, neurons, astrocytes, and oligodendrocytes were generated in all conditions, indicating that TRG permits the multi-lineage differentiation of aOBSCs. However, the total number of cells was reduced on both PEI and TRG. In a serum-containing medium, aOBSC-derived neurons and oligodendrocytes grown on TRG were more numerous than in controls; the neurons developed synaptic boutons and oligodendrocytes were more branched. In contrast, neurons growing on PVDF membranes had reduced neurite branching, and on MWCNTs-loaded membranes oligodendrocytes were lower in numbers than in controls. Overall, these findings indicate that uncoated TRG may be biocompatible with the generation, differentiation, and maturation of aOBSC-derived neurons and glial cells, implying a potential use for TRG to study functional neuronal networks. [less ▲]

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See detailDynamics of the flares in the active polar region of Jupiter
Bonfond, Bertrand ULg; Grodent, Denis ULg; Badman, S. V. et al

in Geophysical Research Letters (2016)

The dusk-side of the polar region of Jupiter's UV aurorae, called the active region, sometimes exhibits quasi-periodic (QP) flares on time-scales of 2-3 minutes. Based on Hubble Space Telescope Far-UV ... [more ▼]

The dusk-side of the polar region of Jupiter's UV aurorae, called the active region, sometimes exhibits quasi-periodic (QP) flares on time-scales of 2-3 minutes. Based on Hubble Space Telescope Far-UV time-tag images, we show for the first time that the northern hemisphere also displays QP-flares. The area covered by these flares can reach up to 2.4 × 108 km2 (i.e. the whole active region), but often only involves an area an order of magnitude smaller. Using a magnetic field mapping model, we deduced that these areas correspond to the dayside outer magnetosphere. In our dataset, quasi-periodic features are only seen on half of the cases and even on a given observation, a region can be quiet for one half and blinking on the other half. Consecutive observations in the two hemispheres show that the brightening can occur in phase. Combined with the size and location of the flares, this behaviour suggests that the QP-flares most likely take place on closed magnetic field lines. [less ▲]

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See detailAging Processes in Lithiated FeSn2 Based Negative Electrode for Li-ion Batteries: a New Challenge for Tin Based Intermetallic Materials
chamas, mohamad; Mahmoud, Abdelfattah ULg; Tang, Junlei et al

in Journal of Physical Chemistry C (2016)

Tin based intermetallic compounds proposed as negative electrode materials for Li-ion batteries not only suffer from capacity fade during cycling due to volume variations but also from aging phenomena in ... [more ▼]

Tin based intermetallic compounds proposed as negative electrode materials for Li-ion batteries not only suffer from capacity fade during cycling due to volume variations but also from aging phenomena in lithiated states. By using FeSn2 as a model compound, we propose an analysis of this process by combining electrochemical potential measurements, 119Sn and 57Fe Mössbauer spectroscopies, magnetic measurements and impedance spectroscopy. We show that the Fe/Li7Sn2 composite obtained at the end of the first discharge is progressively transformed during the aging process occurring within the electrochemical cell in open circuit condition. The Fe nanoparticles are stable while the Li7Sn2 nanoparticles are progressively delithiated with time leading to Sn-rich LixSn nano-alloys without observable back reaction with Fe. The deinserted lithium atoms react with the electrolyte and modify the surface electrode interphase (SEI) by increasing its thickness and/or decreasing its porosity [less ▲]

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See detailLa reconnaissance des génocides et la répression du négationnisme
Grandjean, Geoffrey ULg

in Courrier Hebdomadaire du CRISP (2016), 2304-2305

La reconnaissance politique d’un génocide et la répression de la négation de celui-ci représentent deux enjeux d’une grande importance symbolique. Surtout, elles constituent un exercice très délicat pour ... [more ▼]

La reconnaissance politique d’un génocide et la répression de la négation de celui-ci représentent deux enjeux d’une grande importance symbolique. Surtout, elles constituent un exercice très délicat pour l’autorité politique qui pose de tels actes. Il s’agit en effet de consacrer une vérité historique et de dicter le souvenir qui doit en être véhiculé. L’intervention d’une instance politique dans le champ de l’histoire et de la mémoire est toujours entourée de nombreux débats. Les discussions, souvent vives, portent sur diverses questions. Le principe d’une action législative dans un tel domaine est-il recevable et pertinent ? Quelle définition de « génocide » convient-il d’adopter ? La répression du négationnisme est-elle de nature à justifier une limitation de la liberté d’expression ? Si oui, dans quelle mesure cette restriction s’applique-t-elle aussi aux chercheurs ? Lorsqu’il s’agit d’événements historiques relatifs à un autre État, faut-il faire primer l’éthique et la morale sur la diplomatie ? Les réponses à ces interrogations fondamentales se cristallisent dans des lignes de fracture qui échappent aux clivages partisans classiques. En Belgique, les initiatives de reconnaissance des crimes de génocide et de pénalisation de leur négation sont le fait des deux chambres du Parlement fédéral. Elles ont abouti à diverses dispositions législatives, telles la loi réprimant la négation du génocide commis par le régime nazi à l’encontre des Juifs pendant la Seconde Guerre mondiale (1995), une résolution relative au génocide perpétré par l’Empire ottoman à l’encontre des Arméniens en 1915 (1998), une résolution sur le génocide des Tutsis au Rwanda en 1994 (2004) et une résolution relative à la commémoration du centenaire du génocide arménien (2015). G. Grandjean retrace et éclaire l’ensemble des débats parlementaires qui se sont tenus en Belgique depuis 1992 autour de la question de la mémoire des crimes de masse. Son Courrier hebdomadaire offre les clés de lecture pour la compréhension des débats en cours quant à une extension de la loi de 1995. [less ▲]

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See detailLarge neighborhood search for multi-trip vehicle routing
François, Véronique ULg; Arda, Yasemin ULg; Crama, Yves ULg et al

in European Journal of Operational Research (2016), 255(2), 422-441

We consider the multi-trip vehicle routing problem, in which each vehicle can perform several routes during the same working shift to serve a set of customers. The problem arises when customers are close ... [more ▼]

We consider the multi-trip vehicle routing problem, in which each vehicle can perform several routes during the same working shift to serve a set of customers. The problem arises when customers are close to each other or when their demands are large. A common approach consists of solving this problem by combining vehicle routing heuristics with bin packing routines in order to assign routes to vehicles. We compare this approach with a heuristic that makes use of specific operators designed to tackle the routing and the assignment aspects of the problem simultaneously. Two large neighborhood search heuristics are proposed to perform the comparison. We provide insights into the configuration of the proposed algorithms by analyzing the behavior of several of their components. In particular, we question the impact of the roulette wheel mechanism. We also observe that guiding the search with an objective function designed for the multi-trip case is crucial even when exploring the solution space of the vehicle routing problem. We provide several best known solutions for benchmark instances. [less ▲]

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See detailWASP-157b, a Transiting Hot Jupiter Observed with K2
Močnik, T.; Anderson, D. R.; Brown, D. J. A. et al

in Publications of the Astronomical Society of the Pacific (2016), 970

We announce the discovery of the transiting hot Jupiter WASP-157b in a 3.95-d orbit around a V = 12.9 G2 main-sequence star. This moderately inflated planet has a Saturn-like density with a mass of $0.57 ... [more ▼]

We announce the discovery of the transiting hot Jupiter WASP-157b in a 3.95-d orbit around a V = 12.9 G2 main-sequence star. This moderately inflated planet has a Saturn-like density with a mass of $0.57 \pm 0.10$ M$_{\rm Jup}$ and a radius of $1.06 \pm 0.05$ R$_{\rm Jup}$. We do not detect any rotational or phase-curve modulations, nor the secondary eclipse, with conservative semi-amplitude upper limits of 250 and 20 ppm, respectively. [less ▲]

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See detailKilling it Softly: Girdling as an Efficient Eco-friendly Method to Locally Remove the Invasive Acer negundo
Merceron, Nastasia ULg

in Ecological Restoration (2016), 34(4), 297-305

Acer negundo (boxelder maple) is a North American native tree species that currently invades riparian and disturbed areas in Europe, affecting both bank stability and ecosystem biodiversity. As a response ... [more ▼]

Acer negundo (boxelder maple) is a North American native tree species that currently invades riparian and disturbed areas in Europe, affecting both bank stability and ecosystem biodiversity. As a response to managers’ requests, we aimed at finding an eco-friendly method which would locally remove this species and help habitat restoration. Four control methods were tested on A. negundo adults and saplings from stands located in three experimental sites along different watercourses in Southwestern France: girdling, low cutting, high cutting, and cutting followed by the application of juglone (a natural allelopathic substance from walnut tree leaves). Mortality and resprout production on the treated A. negundo individuals were assessed during two years following the application of the control methods. Girdling was the most efficient method as it significantly induced higher mortality rates compared to the others (65 vs 15% of dead A. negundo two years after treatment administration). When healing emerged on trunks, yearly repeated girdling was required to reach full success. None of the control methods significantly reduced resprout production; not even the application of juglone. Girdling is the most recommended method to kill and remove A. negundo at a local scale in invaded natural habitats. Considering that A. negundo benefits from increases in light availability to outcompete native species, we further recommend removing seedlings from understories when applying girdling on adult and sapling individuals in order to optimize restoration conditions in natural stands and improve native species re-establishment. [less ▲]

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See detailThe IACOB project. IV. New predictions for high-degree non-radial mode instability domains in massive stars and their connection with macroturbulent broadening
Godart, Mélanie ULg; Simón-Díaz, S.; Herrero, A. et al

in Astronomy and Astrophysics (2016), 597

Context. Asteroseismology is a powerful tool to access the internal structure of stars. Apart from the important impact of theoretical developments, progress in this field has been commonly associated ... [more ▼]

Context. Asteroseismology is a powerful tool to access the internal structure of stars. Apart from the important impact of theoretical developments, progress in this field has been commonly associated with the analysis of time-resolved observations. Recently, the so-called macroturbulent broadening has been proposed as a complementary and less expensive way - in terms of observational time - to investigate pulsations in massive stars. <BR /> Aims: We assess to what extent this ubiquitous non-rotational broadening component which shapes the line profiles of O stars and B supergiants is a spectroscopic signature of pulsation modes driven by a heat mechanism. <BR /> Methods: We compute stellar main-sequence and post-main-sequence models from 3 to 70 M[SUB]⊙[/SUB] with the ATON stellar evolution code, and determine the instability domains for heat-driven modes for degrees ℓ = 1-20 using the adiabatic and non-adiabatic codes LOSC and MAD. We use the observational material compiled in the framework of the IACOB project to investigate possible correlations between the single snapshot line-broadening properties of a sample of ≈260 O and B-type stars and their location inside or outside the various predicted instability domains. <BR /> Results: We present an homogeneous prediction for the non-radial instability domains of massive stars for degree ℓ up to 20. We provide a global picture of what to expect from an observational point of view in terms of the frequency range of excited modes, and we investigate the behavior of the instabilities with respect to stellar evolution and the degree of the mode. Furthermore, our pulsational stability analysis, once compared to the empirical results, indicates that stellar oscillations originated by a heat mechanism cannot explain alone the occurrence of the large non-rotational line-broadening component commonly detected in the O star and B supergiant domain. Based on observations made with the Nordic Optical Telescope, operated by NOTSA, and the Mercator Telescope, operated by the Flemish Community, both at the Observatorio del Roque de los Muchachos (La Palma, Spain) of the Instituto de Astrofísica de Canarias. [less ▲]

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See detailIn-depth study of 16CygB using inversion techniques
Buldgen, Gaël ULg; Salmon, Sébastien ULg; Reese, D. R. et al

in Astronomy and Astrophysics (2016), 596

Context. The 16Cyg binary system hosts the solar-like Kepler targets with the most stringent observational constraints. Indeed, we benefit from very high quality oscillation spectra, as well as ... [more ▼]

Context. The 16Cyg binary system hosts the solar-like Kepler targets with the most stringent observational constraints. Indeed, we benefit from very high quality oscillation spectra, as well as spectroscopic and interferometric observations. Moreover, this system is particularly interesting since both stars are very similar in mass but the A component is orbited by a red dwarf, whereas the B component is orbited by a Jovian planet and thus could have formed a more complex planetary system. In our previous study, we showed that seismic inversions of integrated quantities could be used to constrain microscopic diffusion in the A component. In this study, we analyse the B component in the light of a more regularised inversion. <BR /> Aims: We wish to analyse independently the B component of the 16Cyg binary system using the inversion of an indicator dedicated to analyse core conditions, denoted t[SUB]u[/SUB]. Using this independent determination, we wish to analyse any differences between both stars due to the potential influence of planetary formation on stellar structure and/or their respective evolution. <BR /> Methods: First, we recall the observational constraints for 16CygB and the method we used to generate reference stellar models of this star. We then describe how we improved the inversion and how this approach could be used for future targets with a sufficient number of observed frequencies. The inversion results were then used to analyse the differences between the A and B components. <BR /> Results: The inversion of the t[SUB]u[/SUB] indicator for 16CygB shows a disagreement with models including microscopic diffusion and sharing the chemical composition previously derived for 16CygA. We show that small changes in chemical composition are insufficient to solve the problem but that extra mixing can account for the differences seen between both stars. We use a parametric approach to analyse the impact of extra mixing in the form of turbulent diffusion on the behaviour of the t[SUB]u[/SUB] values. We conclude on the necessity of further investigations using models with a physically motivated implementation of extra mixing processes including additional constraints to further improve the accuracy with which the fundamental parameters of this system are determined. [less ▲]

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See detailReplication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number.
Otten, Auke B. C.; Stassen, Alphons P. M.; Adriaens, Michiel et al

in Genetics (2016), 204(4), 1423-1431

Of all pathogenic mitochondrial DNA (mtDNA) mutations in humans, ~25% is de novo, although the occurrence in oocytes has never been directly assessed. We used next generation sequencing to detect point ... [more ▼]

Of all pathogenic mitochondrial DNA (mtDNA) mutations in humans, ~25% is de novo, although the occurrence in oocytes has never been directly assessed. We used next generation sequencing to detect point mutations directly in the mtDNA of 3-15 individual mature oocytes and three somatic tissues from eight zebrafish females. Various statistical and biological filters allowed reliable detection of de novo variants with heteroplasmy >/=1.5%. In total, we detected 38 de novo base substitutions, but no insertions or deletions. These 38 de novo mutations were present in 19 of 103 mature oocytes, indicating that ~20% of the mature oocytes carry at least one de novo mutation with heteroplasmy >/=1.5%. This frequency of de novo mutations is close to that deducted from the reported error rate of polymerase gamma, the mitochondrial replication enzyme, implying that mtDNA replication errors made during oogenesis are a likely explanation. Substantial variation in the mutation prevalence among mature oocytes can be explained by the highly variable mtDNA copy number, since we previously reported that ~20% of the primordial germ cells have a mtDNA copy number of </=73 and would lead to detectable mutation loads. In conclusion, replication errors made during oogenesis are an important source of de novo mtDNA base substitutions and their location and heteroplasmy level determine their significance. [less ▲]

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See detailWASP-92b, WASP-93b and WASP-118b: Three new transiting close-in giant planets
Hay, K. L.; Collier-Cameron, A.; Doyle, A. P. et al

in Monthly Notices of the Royal Astronomical Society (2016), 463

We present the discovery of three new transiting giant planets, first detected with the WASP telescopes, and establish their planetary nature with follow up spectroscopy and ground-based photometric ... [more ▼]

We present the discovery of three new transiting giant planets, first detected with the WASP telescopes, and establish their planetary nature with follow up spectroscopy and ground-based photometric lightcurves. WASP-92 is an F7 star, with a moderately inflated planet orbiting with a period of 2.17 days, which has R[SUB]p[/SUB] = 1.461 ± 0.077R[SUB]J[/SUB] and M[SUB]p[/SUB] = 0.805 ± 0.068M[SUB]J[/SUB]. WASP-93b orbits its F4 host star every 2.73 days and has R[SUB]p[/SUB] = 1.597 ± 0.077R[SUB]J[/SUB] and M[SUB]p[/SUB] = 1.47 ± 0.029M[SUB]J[/SUB]. WASP-118b also has a hot host star (F6) and is moderately inflated, where R[SUB]p[/SUB] = 1.440 ± 0.036R[SUB]J[/SUB] and M[SUB]p[/SUB] = 0.514 ± 0.020M[SUB]J[/SUB] and the planet has an orbital period of 4.05 days. They are bright targets (V = 13.18, 10.97 and 11.07 respectively) ideal for further characterisation work, particularly WASP-118b, which is being observed by K2 as part of campaign 8. The WASP-93 system has sufficient angular momentum to be tidally migrating outwards if the system is near spin-orbit alignment, which is divergent from the tidal behaviour of the majority of hot Jupiters discovered. [less ▲]

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See detailSoluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus
Alzamel, Nidal ULg; Bayrou, Calixte ULg; Decreux, Annabelle et al

in Comparative Immunology, Microbiology and Infectious Diseases (2016), 49

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides ... [more ▼]

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides, 66EQIV69 and 82GQVLAL87, located on antiparallel beta sheets in the most distal complement control protein module (CCP1), provide the attachment platform. In the present study, we reveal new CD46-encoding transcripts that are predicted to encode CCP1-containing soluble forms. Further, we show that the serum of most adult cattle contains soluble CD46 (sCD46) and that a recombinant soluble isoform neutralizes BVDV infectivity in an in vitro assay. We have then established an ELISA for determination of plasma sCD46 in a large cohort of animals. Overall, serum sCD46 amounts to 8 ± 18 ng/mL (mean ± SD, n = 440), with a IC [95-105] ranging from 6,4 to 9,8 ng/mL and extreme values between 0 and 178 ng/mL. We found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood. We also detected high- and low-sCD46 performers and show that this phenotype does not depend of environment. As modern rearing techniques make it possible to disseminate genetically-determined phenotypes very quickly in a population, a large-scale study examining whether high-sCD46 animals provide epidemiological protection against BVDV infection and transmission should be undertaken. [less ▲]

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See detailLes complexes œstrogéniques sélectifs tissulaires : un scoop ou un flop ?
BELIARD, Aude ULg

in Références en Gynécologie Obstétrique (2016), 17(1), 26-29

The controversy surrounding the benefits and risks associated with hormone replacement therapy with combined estrogen and progestin induces the development of new therapies avoiding progestin and its side ... [more ▼]

The controversy surrounding the benefits and risks associated with hormone replacement therapy with combined estrogen and progestin induces the development of new therapies avoiding progestin and its side effects. The tissue selective estrogen complexes pair the positive effect of estrogen with selective estrogen receptor modulator which allows endometrial and breast protection. [less ▲]

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See detailRéforme du bonus logement et instauration du Chèque habitat en Wallonie
Voisin, Fanny ULg

in Les Echos du Logement (2016), 118

Description technique de la réforme du bonus logement entreprise en Région wallonne pour les contrats d’emprunt hypothécaire conclus au plus tard le 31 décembre 2015 et pour les contrats d’emprunt ... [more ▼]

Description technique de la réforme du bonus logement entreprise en Région wallonne pour les contrats d’emprunt hypothécaire conclus au plus tard le 31 décembre 2015 et pour les contrats d’emprunt hypothécaire conclus à partir du 1er janvier 2016. [less ▲]

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See detailEarly exposure to Aroclor 1254 in vivo disrupts the functional synaptic development of newborn hippocampal granule cells.
Parent, Anne-Simone ULg; Pinson, Anneline ULg; Woods, N. et al

in European Journal of Neuroscience (2016), 44(12), 3001-3010

Neurogenesis in the dentate gyrus is sensitive to endogenous and exogenous factors that influence hippocampal function. Ongoing neurogenesis and the integration of these new neurons throughout life thus ... [more ▼]

Neurogenesis in the dentate gyrus is sensitive to endogenous and exogenous factors that influence hippocampal function. Ongoing neurogenesis and the integration of these new neurons throughout life thus may provide a sensitive indicator of environmental stress. We examined the effects of Aroclor 1254 (A1254), a mixture of polychlorinated biphenyls (PCBs), on the development and function of newly generated dentate granule cells. Early exposure to A1254 has been associated with learning impairment in children, suggesting potential impact on the development of hippocampus and/or cortical circuits. Oral A1254 (from the 6th day of gestation to postnatal day 21) produced the expected increase in PCB levels in brain at postnatal day 21, which persisted at lower levels into adulthood. A1254 did not affect the proliferation or survival of newborn neurons in immature animals nor did it cause overt changes in neuronal morphology. However, A1254 occluded the normal developmental increase in sEPSC frequency in the third post-mitotic week without altering the average sEPSC amplitude. Our results suggest that early exposure to PCBs can disrupt excitatory synaptic function during a period of active synaptogenesis, and thus could contribute to the cognitive effects noted in children exposed to PCBs. [less ▲]

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See detailL’impact des connaissances sémantiques préexistantes en mémoire associative dans le vieillissement normal
Folville, Adrien ULg; Delhaye, Emma ULg; Bastin, Christine ULg

in Revue de Neuropsychologie, Neurosciences Cognitives et Cliniques (2016), 8(4), 253-260

The formation of a global and complex episodic memory requires memory for single units of information of the target event but also binding these elements together. This binding capacity diminishes in ... [more ▼]

The formation of a global and complex episodic memory requires memory for single units of information of the target event but also binding these elements together. This binding capacity diminishes in healthy aging leading to a so-called associative memory deficit. Interestingly, when support is provided during encoding thanks to semantic prior-knowledge (e.g., semantically related word pairs), this associative deficit can be alleviated. The aim of the present review is to summarize the current literature about the influence of prior-knowledge on associative memory performance in healthy aging. Through an analysis of the procedures that have been used in associative memory studies, we suggest two factors that appear to modulate the impact of prior knowledge on older adults’ associative memory. First, the way word pairs are recombined from the encoding to the retrieval phase is the main factor that has to be taken into account. Conditions that promote recall-to-reject discrimination processes lead to similar performance in older compared to younger adults, whereas conditions that require recollection discrimination lead to an age-related decline. Second, the nature of the semantic relations involved in the prior-knowledge support may influence older adults’ performance by modulating the contribution of recollection and familiarity to recognition. Indeed, categorical semantic relations engage both recollection and familiarity-based discrimination, whereas thematic relations allow participants to rely on familiarity-based discrimination only. This latest observation is crucial when one considers recollection as a declining process, in contrast to familiarity, which remains spared in healthy aging. Therefore, future studies should explore the propensity of other semantic relations to alleviate the age-related associative memory decline. [less ▲]

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See detailNutritional Composition and Rearing Potential of the Meadow Grasshopper (Chorthippus parallelus Zetterstedt)
Paul, Aman ULg; Frederich, Michel ULg; Uyttenbroeck, Roel ULg et al

in Journal of Asia-Pacific Entomology (2016), 19(4), 1111-1116

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are ... [more ▼]

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are abundantly found throughout Europe. However, these insects were not consumed by Europeans till now, but could possibly be used as human food, which is why we investigated their chemical composition. We found that they contain high level of proteins (69%), with an excellent amino acid profile and protein digestibility (97%). Furthermore, specimens of C. parallelus have an interesting fatty acids profile and minerals composition. Preliminary toxicity assessment indicates that these insects do not exhibit toxicity towards neutrophil cells (white blood cells). These data suggest that C. parallelus could be considered for human consumption. Rearing trials done during the study show that commercial rearing could be developed to produce sufficient biomass for sustaining human consumption. [less ▲]

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See detailThe Dual Role of Neutrophils in Inflammatory Bowel Diseases
Wéra, Odile ULg; Lancellotti, Patrizio ULg; Oury, Cécile ULg

in Journal of clinical medicine (2016), 5(12),

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration ... [more ▼]

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration. These two diseases are considered distinct entities, and there is some evidence that neutrophil behaviour, above all other aspects of immunity, clearly separate them. Neutrophils are the first immune cells recruited to the site of inflammation, and their action is crucial to limit invasion by microorganisms. Furthermore, they play an essential role in proper resolution of inflammation. When these processes are not tightly regulated, they can trigger positive feedback amplification loops that promote neutrophil activation, leading to significant tissue damage and evolution toward chronic disease. Defective chemotaxis, as observed in Crohn's disease, can also contribute to the disease through impaired microbe elimination. In addition, through NET production, neutrophils may be involved in thrombo-embolic events frequently observed in IBD patients. While the role of neutrophils has been studied in different animal models of IBD for many years, their contribution to the pathogenesis of IBD remains poorly understood, and no molecules targeting neutrophils are used and validated for the treatment of these pathologies. Therefore, it is crucial to improve our understanding of their mode of action in these particular conditions in order to provide new therapeutic avenues for IBD. [less ▲]

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See detailSoutenir les proches d'une personne incarcérée. L'accompagnement d'un Service d'Aide aux justiciables.
Garcet, Serge ULg; Lecomte, Romain

in L'Observatoire (2016), 89(novembre/décembre), 46-49

Interview par R. Lecomte dans le cadre du dossier spécial "travail avec les proches" autour de la thématique de l'aide apportée aux détenus et à leurs proches.

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See detailLa vignette thérapeutique de l'étudiant. Le choix entre un inhibiteur de la DPP-4 et un inhibiteur des SGLT2 pour traiter le diabète de type 2 (2016)
SCHEEN, André ULg; PAQUOT, Nicolas ULg

in Revue Médicale de Liège (2016), 71(12), 579-585

Summary : Two new classes of oral antidiabetic agents play an increasing role in the management of type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and sodiumglucose cotransporters ... [more ▼]

Summary : Two new classes of oral antidiabetic agents play an increasing role in the management of type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and sodiumglucose cotransporters type 2 (SGLT2) inhibitors (gliflozins). After failure of a monotherapy with metformin (first pharmacological choice in type 2 diabetes), both may offer an alternative to the add-on of a sulphonylurea, especially in patients at risk of hypoglycaemia. However, the choice between a DPP-4 inhibitor and a SGLT2 inhibitor is not easy and should be oriented based upon the individual patient characteristics. The arguments in favour of one or another pharmacological class are discussed, considering a clinical case of a patient with coronary heart disease and type 2 diabetes not well controlled with metformin. [less ▲]

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See detailLes différentes modalités d’évaluation en accompagnement collectif.
Bernard, Nicolas; Faulx, Daniel ULg

in Education Permanente (2016), 209

L’accompagnement collectif constitue un mode de développement des individus et des équipes qui bénéficie aujourd’hui d’une abondante littérature méthodologique et théorique. Bien que cette question soit ... [more ▼]

L’accompagnement collectif constitue un mode de développement des individus et des équipes qui bénéficie aujourd’hui d’une abondante littérature méthodologique et théorique. Bien que cette question soit moins documentée actuellement, l’accompagnement collectif met en jeu également des démarches d’évaluation qui viennent en appui du processus. Basé sur quatre études de cas, cet article propose une modélisation des différentes possibilités d’évaluations, triées en fonction de quatre critères (niveaux, temporalités, contenus, formes). Chaque modalité est illustrée à l’aide d’un cas fil rouge. Cela débouche sur une multiplicité de possibilités d’application de l’évaluation au service de l’accompagnement. Nous terminons par discuter comment cette pratique peut être théorisée en termes de posture épistémologique. [less ▲]

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See detailQui a peur du style en sociologie de la littérature ?
Stienon, Valérie ULg; Dessy, Clément; van Nuijs, Laurence

in COnTEXTES : Revue de Sociologie de la Littérature (2016), 18

Une certaine idée romantique du style a contribué, depuis le début du XIXe siècle, à développer une conception singularisante du style, qui associe celui-ci à l'expression d'une originalité de l'individu ... [more ▼]

Une certaine idée romantique du style a contribué, depuis le début du XIXe siècle, à développer une conception singularisante du style, qui associe celui-ci à l'expression d'une originalité de l'individu écrivant. Que faire alors de cette conception de la singularité en sociologie de la littérature, discipline qui privilégie l’explication par le collectif et s’attache à situer chaque pratique dans le tout social ? Comment retrouver les traces de l’individu social dans la matière verbale ou la trace écrite qu’il produit ? L’expression et la saisie d’une subjectivité, censées être le propre du style, sont-elles objectivables ? Dans quelle mesure les styles peuvent-ils rencontrer les dynamiques collectives ? Cet article propose un état de la question et quelques pistes méthodologiques à la lumière des approches sociales du littéraire. [less ▲]

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See detailAttack-Prevention and Damage-Control Investments in Cybersecurity
Lam, Wing Man Wynne ULg

in Information Economics and Policy (2016)

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See detail'Migrations Environnementales? Ramener le politique au coeur du débat'
Vigil Diaz Telenti, Sara ULg

in Cités : Philosophie, Politique, Histoire (2016), 68

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See detailDroit et dystopies
Pironnet, Quentin ULg

in Revue Interdisciplinaire d'Etudes Juridiques [= RIEJ] (2016), 77

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