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See detailPoly( N-vinylcaprolactam): A thermoresponsive macromolecule with promising future in biomedical field
Liu, Ji; Debuigne, Antoine ULg; Detrembleur, Christophe ULg et al

in Advanced Healthcare Materials (2014), 3(12), 1941-1968

Poly( N -vinylcaprolactam) (PNVCL) is a thermoresponsive and biocompatible polymer that raises an increasing interest in the biomedical area, especially in drug delivery systems (DDS) that include ... [more ▼]

Poly( N -vinylcaprolactam) (PNVCL) is a thermoresponsive and biocompatible polymer that raises an increasing interest in the biomedical area, especially in drug delivery systems (DDS) that include micelles, hydrogels, and hybrid particles. The thermoresponsiveness of PNVCL, used alone or in combination with other stimuli- responsive polymers or particles (pH, magnetic fi eld, or chemicals), is often key in the loading and/or release process in these DDS. The renewed focus on this polymer, which is known for decades, is to a large extent due to recent progress in synthetic strategies. Especially, the advent of efficient controlled radical polymerization (CRP) methods for NVCL monomer gives now access to unprecedented well-defi ned NVCL-based copolymers with unique properties. This Review article addresses up-to-date synthetic aspects, biological features, and biomedical applications of the latest NVCL-containing systems. [less ▲]

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See detailEmpirical modelling of the bifurcation behaviour of a bridge deck undergoing across-wind galloping
Andrianne, Thomas ULg; Dimitriadis, Grigorios ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2014), 135

This work presents an empirical model capable to describe the galloping bifurcation behaviour of a bridge deck. It is based on a general polynomial form proposed by Novak, which we limit to the 5th order ... [more ▼]

This work presents an empirical model capable to describe the galloping bifurcation behaviour of a bridge deck. It is based on a general polynomial form proposed by Novak, which we limit to the 5th order. The advantage of choosing this function for modelling the vertical force coefficient is that asymmetry of the even terms is enforced in order to reproduce the sub-critical aeroelastic behaviour of the bridge deck. The coefficients of the polynomial are identified from several pairs of displacement amplitudes and the corresponding airspeeds, measured in a wind tunnel during dynamic tests on the sectional bridge model. The identification is carried out using a first order harmonic balance technique. A stability analysis is presented in order to highlight the need of such a model to catch the complete bifurcation behaviour of the system. The resulting force coefficient of this full order model is compared to the well known models of Parkinson and Novak. Finally, the concept universal curve is used in order to discuss the galloping responses of square and rectangular cylinders, in comparison with the one of the bridge deck. [less ▲]

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See detailSpeciation in Malagasy lemurs: a review of the cryptic diversity in genus Lepilemur
Wilmet, Leslie ULg; Schwitzer, Christoph; Devillers, Pierre et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(4), 577-588

Madagascar is one of the highest biodiversity hotspots on the planet; however, it is also one of the most heavily impacted countries in the world in terms of forest degradation and general habitat ... [more ▼]

Madagascar is one of the highest biodiversity hotspots on the planet; however, it is also one of the most heavily impacted countries in the world in terms of forest degradation and general habitat destruction. Genus Lepilemur, in family Lepilemuridae, is a genus of small, nocturnal, exclusively arboreal Malagasy folivores. All species in the genus have small ranges of distribution. Fully forest-dependent, they have a high risk of extinction. Various models and theories of speciation mechanisms have been developed for the fauna and flora of Madagascar. For instance, in the northwestern part of the island, some authors used Lepilemur spp. to test two existing models of distribution: the “Martin model” and “Wilmé model”. Regarding the impact of forest destruction and habitat degradation in Madagascar, conservation strategies for Lepilemur need to be put in place. This paper gives an overview of the current knowledge of the genus Lepilemur and examines speciation for Malagasy lemurs. The understanding of species distribution within biodiversity hotspots is important to identify target for conservation. Therefore, we summarize and compare three biogeography models related to lemurs distribution in order to understand the reasons behind the high diversity (26 species in total) among the genus Lepilemur. Particular attention is also given to the concept of species regarding biodiversity issues and the taxonomic explosion in genus Lepilemur. [less ▲]

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See detailConfiance politique et institutions internationales. Les perceptions de l'efficacité, de la légitimité et de la démocratie par des jeunes
Grandjean, Geoffrey ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 3

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See detailPhysical and bacterial controls on inorganic nutrients and dissolved organic carbon during a sea ice growth and decay experiment
Zhou, Jiayun ULg; Delille, Bruno ULg; Kaartokallio, Hermanni et al

in Marine Chemistry (2014), 166

We investigated how physical incorporation, brine dynamics and bacterial activity regulate the distribution of inorganic nutrients and dissolved organic carbon (DOC) in artificial sea ice during a 19-day ... [more ▼]

We investigated how physical incorporation, brine dynamics and bacterial activity regulate the distribution of inorganic nutrients and dissolved organic carbon (DOC) in artificial sea ice during a 19-day experiment that included periods of both ice growth and decay. The experiment was performed using two series of mesocosms: the first consisted of seawater and the second consisted of seawater enriched with humic-rich river water. We grew ice by freezing the water at an air temperature of -14 °C for 14 days after which ice decay was induced by increasing the air temperature to -1 °C. Using the ice temperatures and bulk ice salinities, we derived the brine volume fractions, brine salinities and Rayleigh numbers. The temporal evolution of these physical parameters indicate that there was a succession of 3 stages in the brine dynamics: forced-convection, followed by bottom convection during ice growth, and then brine stratification during ice decay. The major findings are: (1) the incorporation of dissolved compounds (nitrate, nitrite, ammonium, phosphate, silicate, and DOC) into the sea ice was not conservative (relative to salinity) during ice growth. Brine convection clearly influenced the incorporation of the dissolved compounds, since the non-conservative behavior of the dissolved compounds was particularly pronounced in the absence of brine convection. (2) Bacterial activity further regulated nutrient availability in the ice: ammonium and nitrite accumulated as a result of remineralization processes, although bacterial production was too low to induce major changes in DOC concentrations. (3) Different forms of DOC have different properties and hence incorporation efficiencies. In particular, the terrestrially-derived DOC from the river water was less efficiently incorporated into sea ice than the DOC in the seawater. Therefore the main factors regulating the distribution of the dissolved compounds within sea ice are clearly a complex interaction of brine dynamics, biological activity and in the case of dissolved organic matter, the physico-chemical properties of the dissolved constituents themselves. [less ▲]

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See detailLong-term evolution and seasonal modulation of methanol above Jungfraujoch (46.5°N, 8.0°E): Optimisation of the retrieval strategy, comparison with model and independant observations
Bader, Whitney ULg; Stavrakou, T; Muller, J-F et al

in Atmospheric Measurement Techniques (2014), 7

Methanol (CH3OH) is the second most abundant organic compound in the Earth's atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and ... [more ▼]

Methanol (CH3OH) is the second most abundant organic compound in the Earth's atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and upper tropospheric-lower stratospheric partial columns derived from the analysis of high resolution Fourier transform infrared solar spectra recorded at the Jungfraujoch station (46.5° N, 3580 m a.s.l.). The retrieval of methanol is very challenging due to strong absorptions of ozone in the region of the selected υ8 band of CH3OH. Two wide spectral intervals have been defined and adjusted in order to maximize the information content. Methanol does not exhibit a significant trend over the 1995–2012 time period, but a strong seasonal modulation characterized by maximum values and variability in June–July, minimum columns in winter and a peak-to-peak amplitude of 130%. In situ measurements performed at the Jungfraujoch and ACE-FTS occultations give similar results for the methanol seasonal variation. The total and lower tropospheric columns are also compared with IMAGESv2 model simulations. There is no systematic bias between the observations and IMAGESv2 but the model underestimates the peak-to-peak amplitude of the seasonal modulations. [less ▲]

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See detailDouble thermoresponsive di- and triblock copolymers based on N-vinylcaprolactam and N-vinylpyrrolidone: synthesis and comparative study of solution behaviour
Kermagoret, Anthony ULg; Mathieu, Kevin ULg; Thomassin, Jean-Michel ULg et al

in Polymer Chemistry (2014), 5(22), 6534-6544

Poly(N-vinylcaprolactam) (PNVCL) and poly(N-vinylpyrrolidone) (PNVP) are water soluble polymers of interest especially in the biomedical field. Moreover, PNVCL is characterized by a lower critical ... [more ▼]

Poly(N-vinylcaprolactam) (PNVCL) and poly(N-vinylpyrrolidone) (PNVP) are water soluble polymers of interest especially in the biomedical field. Moreover, PNVCL is characterized by a lower critical solution temperature close to 36 °C in water, which makes it useful for the design of thermoresponsive systems. In this context, we used the cobalt-mediated radical polymerization (CMRP) and reaction coupling (CMRC) for synthesizing a series of well-defined NVCL and NVP-based copolymers, including statistical copolymers as well as double thermoresponsive diblocks and triblocks. Dynamic light scattering and turbidimetry analyses highlighted the crucial impact of the copolymer composition and architecture on the cloud point temperature (TCP) of each segment and also their influence on the multistep assembly behaviour of block copolymers. Addition of NaCl enabled us to adjust the inter-TCP range of the di- and triblock in which selective precipitation of one block and self-assembly of the copolymer were favoured. Overall, data presented here provide a basis for the synthesis of a broad range of NVCL/NVP based copolymer architectures with a tunable thermal response in water. [less ▲]

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See detailAllelopathic and autotoxicity effects of barley (Hordeum vulgare L. ssp. vulgare) root exudates
Bouhaouel, Imen; Gfeller, Aurélie; Fauconnier, Marie-Laure ULg et al

in BioControl (2014), Online First

The allelopathic activity of barley (Hordeum vulgare L. ssp. vulgare) root exudates was studied by comparing their effects on seedling establishment in barley itself and in two weed species, Bromus ... [more ▼]

The allelopathic activity of barley (Hordeum vulgare L. ssp. vulgare) root exudates was studied by comparing their effects on seedling establishment in barley itself and in two weed species, Bromus diandrus Roth. and Lolium rigidum Gaudin, using an original laboratory protocol, named ‘seed-after-seed’. In this protocol, the donor and the receiver species of watersoluble allelochemicals are grown one after the other in the same dishes, in conditions reducing resource competition between both species. Growth of all receptive species (weeds and barley) was inhibited in a dose-dependent manner, when using increasing barley seed densities (0, 8, 19 and 25 seeds per Petri dish). In our conditions, the barley varieties and landraces exhibited different allelopathic activities against weeds or barley. The allelopathic potential of the barley root exudates was also dependent on the receiver species. Indeed, the released allelochemicals proved to be more toxic against the weed plants than on barley itself. Furthermore, the toxicity of the allelochemicals increased after their release by roots, between day 0 and day 6. These allelochemicals might contribute to the plant community dynamics and their usefulness as bio-herbicides deserves further consideration. [less ▲]

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See detailSoil charcoal to assess the impacts of past human disturbances on tropical forests
Vleminckx, Jason; Morin-Rivat, Julie ULg; Biwolé, Achille et al

in PLoS ONE (2014)

The canopy of many central African forests is dominated by light-demanding tree species that do not regenerate well under themselves. The prevalence of these species might result from ancient slash-and ... [more ▼]

The canopy of many central African forests is dominated by light-demanding tree species that do not regenerate well under themselves. The prevalence of these species might result from ancient slash-and-burn agricultural activities that created large openings, while a decline of these activities since the colonial period could explain their deficit of regeneration. To verify this hypothesis, we compared soil charcoal abundance, used as a proxy for past slash-and-burn agriculture, and tree species composition assessed on 208 rainforest 0.2 ha plots located in three areas from Southern Cameroon. Species were classified in regeneration guilds (pioneer, non-pioneer light-demanding, shade-bearer) and characterized by their woodspecific gravity, assumed to reflect light requirement. We tested the correlation between soil charcoal abundance and: (i) the relative abundance of each guild, (ii) each species and family abundance and (iii) mean wood-specific gravity. Charcoal was found in 83% of the plots, indicating frequent past forest fires. Radiocarbon dating revealed two periods of fires: ‘‘recent’’ charcoal were on average 300 years old (up to 860 BP, n = 16) and occurred in the uppermost 20 cm soil layer, while ‘‘ancient’’ charcoal were on average 1900 years old (range: 1500 to 2800 BP, n = 43, excluding one sample dated 9400 BP), and found in all soil layers. While we expected a positive correlation between the relative abundance of light demanding species and charcoal abundance in the upper soil layer, overall there was no evidence that the current heterogeneity in tree species composition can be explained by charcoal abundance in any soil layer. The absence of signal supporting our hypothesis might result from (i) a relatively uniform impact of past slash-and-burn activities, (ii) pedoturbation processes bringing ancient charcoal to the upper soil layer, blurring the signal of centuries-old Human disturbances, or (iii) the prevalence of other environmental factors on species composition. [less ▲]

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See detailSurvey of Artificial Insemination Practices in Algeria
Souames, Samir; Hanzen, Christian ULg; Detilleux, Johann ULg et al

in Research Journal for Veterinary Practitioner (2014), 3(1), 1-9

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See detailRecent Northern Hemisphere stratospheric HCl increase due to atmospheric circulation changes
Mahieu, Emmanuel ULg; Chipperfield, M. P.; Notholt, J. et al

in Nature (2014), 515(7525), 104--107

The abundance of chlorine in the Earth’s atmosphere increased considerably during the 1970s to 1990s, following large emissions of anthropogenic long-lived chlorine-containing source gases, notably the ... [more ▼]

The abundance of chlorine in the Earth’s atmosphere increased considerably during the 1970s to 1990s, following large emissions of anthropogenic long-lived chlorine-containing source gases, notably the chlorofluorocarbons. The chemical inertness of chlorofluorocarbons allows their transport and mixing throughout the troposphere on a global scale[1], before they reach the stratosphere where they release chlorine atoms that cause ozone depletion[2]. The large ozone loss over Antarctica[3] was the key observation that stimulated the definition and signing in 1987 of the Montreal Protocol, an international treaty establishing a schedule to reduce the production of the major chlorine- and bromine-containing halocarbons. Owing to its implementation, the near-surface total chlorine concentration showed a maximum in 1993, followed by a decrease of half a per cent to one per cent per year[4], in line with expectations. Remote-sensing data have revealed a peak in stratospheric chlorine after 1996[5], then a decrease of close to one per cent per year[6,7], in agreement with the surface observations of the chlorine source gases and model calculations[7]. Here we present ground-based and satellite data that show a recent and significant increase, at the 2σ level, in hydrogen chloride (HCl), the main stratospheric chlorine reservoir, starting around 2007 in the lower stratosphere of the Northern Hemisphere, in contrast with the ongoing monotonic decrease of near-surface source gases. Using model simulations, we attribute this trend anomaly to a slowdown in the Northern Hemisphere atmospheric circulation, occurring over several consecutive years, transporting more aged air to the lower stratosphere, and characterized by a larger relative conversion of source gases to HCl. This short-term dynamical variability will also affect other stratospheric tracers and needs to be accounted for when studying the evolution of the stratospheric ozone layer. [less ▲]

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See detailThe Robust Economic Statistical Design of the Hotelling’s T^2 Chart
Faraz, Alireza ULg; Chalaki, Kamyar; Saniga, Erwin et al

in Communications in Statistics : Theory & Methods (2014)

Economic statistical designs aim at minimizing the cost of process monitoring when a specific scenario or a set of estimated process and cost parameters is given. However, in practical situations the ... [more ▼]

Economic statistical designs aim at minimizing the cost of process monitoring when a specific scenario or a set of estimated process and cost parameters is given. However, in practical situations the process may be affected by more than one scenario which may lead to severe cost penalties for upsetting the true scenario. This paper presents the robust economic statistical design (RESD) of the T^2 chart to reduce the monetary losses when there are multiple distinct scenarios. The genetic algorithm optimization method is employed here to minimize the total expected monitoring cost across all distinct scenarios. Through two numerical examples the proposed method is illustrated. Simulation studies indicate that the robust economic statistical designs should be encouraged in practice. [less ▲]

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See detailOrigin and immunoescape of uterine cervical cancer
Van hede, Dorien ULg; Langers, Inge ULg; DELVENNE, Philippe ULg et al

in Presse Médicale (2014)

Human papillomavirus associated uterine cervical cancer is an important public health problem since it is classified as the fourth most common cancer in women worldwide with more than 500 000 recorded ... [more ▼]

Human papillomavirus associated uterine cervical cancer is an important public health problem since it is classified as the fourth most common cancer in women worldwide with more than 500 000 recorded cases. This review is focused on where and why HPV infection induces cervical cancers and how this virus avoids the host immune response. Immunological therapeutic approaches are also addressed. [less ▲]

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See detailSouthern Massive Stars at High Angular Resolution: Observational Campaign and Companion Detection
Sana, H.; Le Bouquin, J.-B.; Lacour, S. et al

in Astrophysical Journal Supplement Series (2014), 215

Multiplicity is one of the most fundamental observable properties of massive O-type stars and offers a promising way to discriminate between massive star formation theories. Nevertheless, companions at ... [more ▼]

Multiplicity is one of the most fundamental observable properties of massive O-type stars and offers a promising way to discriminate between massive star formation theories. Nevertheless, companions at separations between 1 and 100 milliarcsec (mas) remain mostly unknown due to intrinsic observational limitations. At a typical distance of 2 kpc, this corresponds to projected ph [less ▲]

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See detailOccurence of Satellite RNAs associated with Cucumber mosaic virus isolated from banana (Musa sp.) in Ivory Coast
Kouadio, Kouakou Théodore; De Clerck, Caroline ULg; Agneroh, TA et al

in British Society for Plant Pathology - New Disease Reports (2014), 30

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See detailA near-infrared interferometric survey of debris-disk stars. IV. An unbiased sample of 92 southern stars observed in H band with VLTI/PIONIER
Ertel, S.; Absil, Olivier ULg; Defrere, D. et al

in Astronomy and Astrophysics (2014), 570

Context. Detecting and characterizing circumstellar dust is a way to study the architecture and evolution of planetary systems. Cold dust in debris disks only traces the outer regions. Warm and hot ... [more ▼]

Context. Detecting and characterizing circumstellar dust is a way to study the architecture and evolution of planetary systems. Cold dust in debris disks only traces the outer regions. Warm and hot exozodiacal dust needs to be studied in order to trace regions close to the habitable zone. <BR /> Aims: We aim to determine the prevalence and to constrain the properties of hot exozodiacal dust around nearby main-sequence stars. <BR /> Methods: We searched a magnitude-limited (H <= 5) sample of 92 stars for bright exozodiacal dust using our VLTI visitor instrument PIONIER in the H band. We derived statistics of the detection rate with respect to parameters, such as the stellar spectral type and age or the presence of a debris disk in the outer regions of the systems. We derived more robust statistics by combining our sample with the results from our CHARA/FLUOR survey in the K band. In addition, our spectrally dispersed data allowed us to put constraints on the emission mechanism and the dust properties in the detected systems. <BR /> Results: We find an overall detection rate of bright exozodiacal dust in the H band of 11% (9 out of 85 targets) and three tentative detections. The detection rate decreases from early type to late type stars and increases with the age of the host star. We do not confirm the tentative correlation between the presence of cold and hot dust found in our earlier analysis of the FLUOR sample alone. Our spectrally dispersed data suggest that either the dust is extremely hot or the emission is dominated by the scattered light in most cases. The implications of our results for the target selection of future terrestrial planet-finding missions using direct imaging are discussed. [less ▲]

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See detailSearching for faint companions with VLTI/PIONIER. II. 92 main sequence stars from the Exozodi survey
Marion, Lindsay ULg; Absil, Olivier ULg; Ertel, S. et al

in Astronomy and Astrophysics (2014), 570

Context. The Exozodi survey aims to determine the occurrence rate of bright exozodiacal discs around nearby main sequence stars using infrared interferometry. Although the Exozodi survey targets have been ... [more ▼]

Context. The Exozodi survey aims to determine the occurrence rate of bright exozodiacal discs around nearby main sequence stars using infrared interferometry. Although the Exozodi survey targets have been carefully selected to avoid the presence of binary stars, the results of this survey can still be biased by the presence of unidentified stellar companions. <BR /> Aims: Using the PIONIER data set collected within the Exozodi survey in 2012, we aim to search for the signature of point-like companions around the Exozodi target stars. <BR /> Methods: We make use of both the closure phases and squared visibilities collected by PIONIER to search for companions within the ~100 mas interferometric field of view. The presence of a companion is assessed by computing the goodness of fit to the data for a series of binary models with various separations and contrasts. <BR /> Results: Five stellar companions are resolved for the first time around five A-type stars: HD 4150, HD 16555, HD 29388, HD 202730, and HD 224392 (although the companion to HD 16555 was independently resolved by speckle interferometry while we were carrying out the survey). In the most likely case of main sequence companions, their spectral types range from A5V to K4V. Three of these stars were already suspected to be binaries from Hipparcos astrometric measurements, although no information was available on the companions themselves so far. In addition to debiasing the statistics of the Exozodi survey, these results can also be used to revise the fraction of visual binaries among A-type stars, suggesting that an extra ~13% A-type stars are visual binaries in addition to the ones detected in previous direct imaging surveys. <BR /> Conclusions: We estimate that about half the population of nearby A-type stars could be resolved as visual binaries using a combination of state-of-the-art interferometry and single-aperture imaging, and we suggest that a significant fraction of these binaries remains undetected to date. [less ▲]

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See detailEconomic Statistical Design of the VP( X) ̅ Control Charts for Monitoring a Process under Non-normality
Seif, Asghar; Faraz, Alireza ULg; Saniga, Erwin

in International Journal of Production Research (2014)

Recent studies proved that variable parameters (VP) X ̅ control charts not only detects process mean shifts quicker than the classical X ̅ control chart but also has better economic properties ... [more ▼]

Recent studies proved that variable parameters (VP) X ̅ control charts not only detects process mean shifts quicker than the classical X ̅ control chart but also has better economic properties. Furthermore, like most papers in control chart design, the fundamental assumption is that process data are normally distributed. Nevertheless, process quality variables may not be normal in application. In this paper, we investigate the economic statistical design of the VP X ̅ control chart when the underlying process distribution is non-normal. We illustrate the design procedure and perform a sensitivity analysis on the process and cost parameters based upon the degrees of skewness and kurtosis of the population using an industrial application. [less ▲]

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See detailBuilding galaxies, stars, planets and the ingredients for life between the stars. The science behind the European Ultraviolet-Visible Observatory
Gómez de Castro, Ana I.; Appourchaux, Thierry; Barstow, Martin A. et al

in Astrophysics and Space Science (2014), 354

This contribution gathers the contents of the white paper submitted by the UV community to the Call issued by the European Space Agency in March 2013, for the definition of the L2 and L3 missions in the ... [more ▼]

This contribution gathers the contents of the white paper submitted by the UV community to the Call issued by the European Space Agency in March 2013, for the definition of the L2 and L3 missions in the ESA science program. We outlined the key science that a large UV facility would make possible and the instrumentation to be implemented. The growth of luminous structures and the building blocks of life in the Universe began as primordial gas was processed in stars and mixed at galactic scales. The mechanisms responsible for this development are not well-understood and have changed over the intervening 13 billion years. To follow the evolution of matter over cosmic time, it is necessary to study the strongest (resonance) transitions of the most abundant species in the Universe. Most of them are in the ultraviolet (UV; 950 Å-3000 Å) spectral range that is unobservable from the ground. A versatile space observatory with UV sensitivity a factor of 50-100 greater than existing facilities will revolutionize our understanding of the Universe. Habitable planets grow in protostellar discs under ultraviolet irradiation, a by-product of the star-disk interaction that drives the physical and chemical evolution of discs and young planetary systems. The electronic transitions of the most abundant molecules are pumped by this UV field, providing unique diagnostics of the planet-forming environment that cannot be accessed from the ground. Earth's atmosphere is in constant interaction with the interplanetary medium and the solar UV radiation field. A 50-100 times improvement in sensitivity would enable the observation of the key atmospheric ingredients of Earth-like exoplanets (carbon, oxygen, ozone), provide crucial input for models of biologically active worlds outside the solar system, and provide the phenomenological baseline to understand the Earth atmosphere in context. [less ▲]

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See detailThe effects of rater bias on hypothesis testing when using different assessment methods for estimating disease severity.
CHIANG, KUO-SZU; Bock, Clive; El Jarroudi, Moussa ULg et al

in Phytopathology (2014), 104(11), 26

Bias (over and underestimates) in estimates of disease severity, and the impact of that inaccuracy on hypothesis testing using different disease scales was explored. Nearest percent estimates (NPE), the ... [more ▼]

Bias (over and underestimates) in estimates of disease severity, and the impact of that inaccuracy on hypothesis testing using different disease scales was explored. Nearest percent estimates (NPE), the Horsfall-Barratt (H-B) scale and four different linear category scales (5% and 10% increments, with and without additional grades at low severity) were compared. Actual values and estimates by 4 different raters of the severity (0 to 100%) of Septoria leaf blotch on leaves of winter wheat were used to develop distributions for a simulation model. The simulations were based on i) all the 4 raters data combined, ii) only the most accurate rater estimates, and iii) only the most biased rater. Regardless of the effect of rater ability, we found that, there were lower type II error rates with NPEs as compared with the other category scales at severities of 80 to 100%. On the other hand, with lower severities (0 to 20%), the 5% and 10% scales with additional grades had type II error rates comparable to those for the NPEs. Raters who overestimated severity and used the H-B scale had the highest risk of a type II error when the mean disease severity was low. Knowledge of how rater ability and scale type can affect hypothesis testing can be used to improve disease assessment as well as to provide a logical framework for developing standard area diagrams. [less ▲]

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See detailInstrumental methods for professional and amateur collaborations in planetary astronomy
Mousis, O.; Hueso, R.; Beaulieu, J.-P. et al

in Experimental Astronomy (2014), 38

Amateur contributions to professional publications have increased exponentially over the last decades in the field of planetary astronomy. Here we review the different domains of the field in which ... [more ▼]

Amateur contributions to professional publications have increased exponentially over the last decades in the field of planetary astronomy. Here we review the different domains of the field in which collaborations between professional and amateur astronomers are effective and regularly lead to scientific publications.We discuss the instruments, detectors, software and methodologies typically used by amateur astronomers to collect the scientific data in the different domains of interest. Amateur contributions to the monitoring of planets and interplanetary matter, characterization of asteroids and comets, as well as the determination of the physical properties of Kuiper Belt Objects and exoplanets are discussed. [less ▲]

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See detailA comparison of raters and disease assessment methods for estimating disease severity for purposes of hypothesis testing.
Bock, Clive; El Jarroudi, Moussa ULg; Kouadio, Louis et al

in Phytopathology (2014), 104(11), 26

Assessment of disease severity is most often made visually, and estimates can be inaccurate. Nearest percent estimates (NPEs) of Septoria leaf blotch on leaves of winter wheat by four raters (R1-R4 ... [more ▼]

Assessment of disease severity is most often made visually, and estimates can be inaccurate. Nearest percent estimates (NPEs) of Septoria leaf blotch on leaves of winter wheat by four raters (R1-R4) assessing non-treated (NT) and fungicide-treated (FT) plots were compared to true values using Lin’s concordance correlation coefficient (ρc) on two dates in 2006 and 2007. Estimates were converted to Horsfall-Barratt (HB) mid-points and again compared for accuracy and precision. Estimates of severity from FT and NT plots were analyzed to ascertain effects of rater using both the NPE and HB values. Regardless of method, all raters showed a range of agreement with true values on FT and NT plots (ρc = 0 to 1). Use of the HB scale most often reduced agreement (84.4% of the time), and did not improve rater-associated bias of treatment mean severity estimates. Consequently, estimates of mean severity differed significantly among raters and from true values (F=126 to 1260, P=0.002 to<0.0001). However, a comparison of treatment effects showed that the true values and R1 to R4 all demonstrated significant effects of fungicide (F=101 to 1952, P=0.002 to <0.00001). Ranking of raters differed on one occasion when HB values were used. These results demonstrate the effect of the HB scale, and the need for accurate disease assessment to minimize over or underestimates compared to true severity so as to minimize the potential for type II errors. [less ▲]

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See detailX-Ray Emission from Magnetic Massive Stars
Nazé, Yaël ULg; Petit, Véronique; Rinbrand, Melanie et al

in The Astrophysical Journal Supplement Series (2014), 215

Magnetically confined winds of early-type stars are expected to be sources of bright and hard X-rays. To clarify the systematics of the observed X-ray properties, we have analyzed a large series of ... [more ▼]

Magnetically confined winds of early-type stars are expected to be sources of bright and hard X-rays. To clarify the systematics of the observed X-ray properties, we have analyzed a large series of Chandra and XMM-Newton observations, corresponding to all available exposures of known massive magnetic stars (over 100 exposures covering ~60% of stars compiled in the catalog of Petit et al.). We show that the X-ray luminosity is strongly correlated with the stellar wind mass-loss rate, with a power-law form that is slightly steeper than linear for the majority of the less luminous, lower-{\dot{M}} B stars and flattens for the more luminous, higher-{\dot{M}} O stars. As the winds are radiatively driven, these scalings can be equivalently written as relations with the bolometric luminosity. The observed X-ray luminosities, and their trend with mass-loss rates, are well reproduced by new MHD models, although a few overluminous stars (mostly rapidly rotating objects) exist. No relation is found between other X-ray properties (plasma temperature, absorption) and stellar or magnetic parameters, contrary to expectations (e.g., higher temperature for stronger mass-loss rate). This suggests that the main driver for the plasma properties is different from the main determinant of the X-ray luminosity. Finally, variations of the X-ray hardnesses and luminosities, in phase with the stellar rotation period, are detected for some objects and they suggest that some temperature stratification exists in massive stars' magnetospheres. Based on data collected with XMM-Newton and Chandra. [less ▲]

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See detailLe langage et l’homme
Dubuisson, Francois ULg

in Bulletin d'Analyse Phénoménologique [En ligne] (2014), 10(11),

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See detailDisease severity assessment in epidemiological studies: accuracy and reliability of visual estimates of Septoria leaf blotch (SLB) in winter wheat.
El Jarroudi, Moussa ULg; Kouadio, Louis; Mackels, Christophe et al

in Phytopathology (2014), 104(11), 37

The accuracy and reliability of visual assessments of SLB severity by raters (i.e. one plant pathologist with extensive experience and three other raters trained prior to field observations using standard ... [more ▼]

The accuracy and reliability of visual assessments of SLB severity by raters (i.e. one plant pathologist with extensive experience and three other raters trained prior to field observations using standard area diagrams and DISTRAIN) was determined by comparison with assumed actual values obtained by digital image analysis. Initially analyses were performed using SLB severity over the full 0-100% range; then, to explore error over short ranges of the 0-100% scale, the scale was divided into sequential 10%-increments based on the actual values. Lin’s concordance correlation (LCC) analysis demonstrated that all raters were accurate when compared over the whole severity range (LCC coefficient (ρc)= 0.92-0.99). However, agreement between actual and visual SLB severities was less good when compared over the short intervals of the 10×10% classes (ρc= -0.12-0.99), demonstrating that agreement will vary depending on the actual disease range over which it is compared. Inter-rater reliability between each pair of raters over the full 0-100% range (correlation analysis r= 0.970-0.992, P<0.0001), and inter-class correlation coefficient (ρ≥ 0.927) were very high. This study provides new insight into using a full range of actual disease severity vs limited ranges to ensure a realistic measure of rater accuracy and reliability, in addition to contributing to the ongoing debate on the use of visual disease estimates based on the 0-100% ratio scale for epidemiological research. [less ▲]

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See detailMapping French terms in a Belgian guideline on heart failure to international classifications and nomenclatures: the devil is in the detail.
Jamoulle, Marc ULg; Cardillo, Elena; Roumier, Joseph et al

in Informatics in Primary Care (2014), 4

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies ... [more ▼]

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies more stringent demands on the quality of data-entry at the point-of-care. Non-native English speaking general practitioners experience difficulties in interacting with international classification systems and nomenclatures to facilitate the secondary use of their data and to ensure semantic interoperability. Aim: To identify words and phrases pertaining to the heart failure domain and to explore the difficulties in mapping to corresponding concepts in ICPC-2, ICD-10, SNOMED-CT, and UMLS. Methods: The medical concepts in a Belgian guideline for General Practitioners (GPs) in its French version were extracted manually and coded first in ICPC-2, then ICD-10 by a physician, an expert in classification systems. In addition, mappings were sought with SNOMED-CT and UMLS concepts, using the UMLS SNOMED-CT browser. Results: We retained 143 words and phrases, of which 128 referred to a single concept (1-to-1 mapping), while 15 referred to 2 or more concepts (1-to-n mapping to ICPC rubrics or to the other nomenclatures). In the guideline, words or phrases were often too general for adequate correspondence. Marked discrepancy between semantic tags and types was found. Conclusion: This study illustrates the variability of the various international classifications and nomenclatures, the need for structured guidelines with more attention to precise wording, and the need for classification expertise embedded in sophisticated terminological resources. End-users need support to perform their clinical work in their own language, while still assuring standardized and semantic interoperable medical registration. Collaboration between computational linguists, knowledge engineers, health informaticians and domain experts is needed. [less ▲]

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See detailProjections graphiques de quelques espaces de la vie sociale au Japon
Badir, Sémir ULg

in Lexia (2014), 17-18

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See detail"Über Ländergrenzen hinaus" - Der Deutsche Buchpreis und seine Wirkung
Houscheid, Karin ULg

in Literaturkritik.de (2014)

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See detailA BCool magnetic snapshot survey of solar-type stars
Marsden, S.C.; Petit, P.; Jeffers, S.V. et al

in Monthly Notices of the Royal Astronomical Society (2014), 444

We present the results of a major high-resolution spectropolarimetric BCool project magnetic survey of 170 solar-type stars. Surface magnetic fields were detected on 67 stars, with 21 classified as mature ... [more ▼]

We present the results of a major high-resolution spectropolarimetric BCool project magnetic survey of 170 solar-type stars. Surface magnetic fields were detected on 67 stars, with 21 classified as mature solar-type stars, a result that increases by a factor of 4 the number of mature solar-type stars on which magnetic fields have been observed. In addition, a magnetic field was detected for 3 out of 18 of the subgiant stars surveyed. For the population of K-dwarfs, the mean value of |Bl| (|Bl|mean) was also found to be higher (5.7 G) than |Bl|mean measured for the G-dwarfs (3.2 G) and the F-dwarfs (3.3 G). For the sample as a whole, |Bl|mean increases with rotation rate and decreases with age, and the upper envelope for |Bl| correlates well with the observed chromospheric emission. Stars with a chromospheric S-index greater than about 0.2 show a high magnetic field detection rate and so offer optimal targets for future studies. This survey constitutes the most extensive spectropolarimetric survey of cool stars undertaken to date, and suggests that it is feasible to pursue magnetic mapping of a wide range of moderately active solar-type stars to improve our understanding of their surface fields and dynamos. [less ▲]

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See detailLes progrès de la poésie en 1867. Portrait de Gautier en grand rapporteur
Durand, Pascal ULg

in Bulletin de la Société Théophile Gautier (2014), 36

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See detailLes inhibiteurs de la PSCK9: une innovation majeure dans le traitement des dyslipidémies ?
PAQUOT, Nicolas ULg

in ABD- le supplément du médecin (2014), 57(6), 6-7

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See detailPrediction of mean and turbulent kinetic energy in rectangular shallow reservoirs
Camnasio, Erica; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Engineering Applications of Computational Fluid Mechanics (2014), 8(4),

Shallow rectangular reservoirs are common structures in urban hydraulics and river engineering. Despite their simple geometry, complex symmetric and asymmetric flow fields develop in such reservoirs ... [more ▼]

Shallow rectangular reservoirs are common structures in urban hydraulics and river engineering. Despite their simple geometry, complex symmetric and asymmetric flow fields develop in such reservoirs, depending on their expansion ratio and length-to-width ratio. The original contribution of this study is the analysis of the kinetic energy content of the mean flow, based on UVP velocity measurements carried throughout the reservoir in eleven different geometric configurations. A new relationship is derived between the specific mean kinetic energy and the reservoir shape factor. For most considered geometric configurations, leading to four different flow patterns, the experimentally observed flow fields and mean kinetic energy contents are successfully reproduced by an operational numerical model based on the depth-averaged flow equations and a two-length-scale k-e turbulence closure. The analysis also highlights the better performance of this depth-averaged k-e model compared to an algebraic turbulence model. Finally, the turbulent kinetic energy in the reservoir is derived from the experimental measurements and the corresponding numerical predictions based on the k-e model agree satisfactorily in the main jet but not in the recirculation zones. [less ▲]

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See detailComparison of the Decomposition VOC Profile during Winter and Summer in a Moist, Mid-latitude (Cfb) Climate
Forbes, Shari L.; Perrault, Katelynn A.; Stefanuto, Pierre-Hugues ULg et al

in PLoS ONE (2014), 9(e113681), 1-11

The investigation of volatile organic compounds (VOCs) associated with decomposition is an emerging field in forensic taphonomy due to their importance in locating human remains using biological detectors ... [more ▼]

The investigation of volatile organic compounds (VOCs) associated with decomposition is an emerging field in forensic taphonomy due to their importance in locating human remains using biological detectors such as insects and canines. A consistent decomposition VOC profile has not yet been elucidated due to the intrinsic impact of the environment on the decomposition process in different climatic zones. The study of decomposition VOCs has typically occurred during the warmer months to enable chemical profiling of all decomposition stages. The present study investigated the decomposition VOC profile in air during both warmer and cooler months in a moist, mid-latitude (Cfb) climate as decomposition occurs year-round in this environment. Pig carcasses (Sus scrofa domesticus L.) were placed on a soil surface to decompose naturally and their VOC profile was monitored during the winter and summer months. Corresponding control sites were also monitored to determine the natural VOC profile of the surrounding soil and vegetation. VOC samples were collected onto sorbent tubes and analyzed using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC6GC-TOFMS). The summer months were characterized by higher temperatures and solar radiation, greater rainfall accumulation, and comparable humidity when compared to the winter months. The rate of decomposition was faster and the number and abundance of VOCs was proportionally higher in summer. However, a similar trend was observed in winter and summer demonstrating a rapid increase in VOC abundance during active decay with a second increase in abundance occurring later in the decomposition process. Sulfur-containing compounds, alcohols and ketones represented the most abundant classes of compounds in both seasons, although almost all 10 compound classes identified contributed to discriminating the stages of decomposition throughout both seasons. The advantages of GC6GC-TOFMS were demonstrated for detecting and identifying trace levels of VOCs, particularly ethers, which are rarely reported as decomposition VOCs. [less ▲]

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See detailSputum cytokines levels in patients undergoing hematopoietic SCT (HSCT) and comparison with healthy subjects and COPD: a pilot study
MOERMANS, Catherine ULg; BONNET, Christophe ULg; WILLEMS, Evelyne ULg et al

in Bone Marrow Transplantation (2014), 49(11), 1382-1388

Patients undergoing hematopoietic stem cell transplantation (HSCT) display an airway neutrophilic inflammation before the transplantation that persists over the years. In this study, we have investigated ... [more ▼]

Patients undergoing hematopoietic stem cell transplantation (HSCT) display an airway neutrophilic inflammation before the transplantation that persists over the years. In this study, we have investigated the cytokine profile over a period of one year in sputum supernatant of patients who underwent HSCT. We have measured sputum supernatant levels of TNF-α, TGF-β1, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17, and IFN-γ in 49 HSCT patients and compared the results with those found in 40 COPD and 54 healthy subjects matched for age. Compared to healthy subjects, before the transplantation, HSCT patients exhibited raised levels of IL-6 (p<0.001) and IL-8 (p<0.05) while the other cytokines were generally poorly detectable. This picture was rather similar to what is seen in COPD even if cytokine levels were much greater in the latter with IL-8 being significantly greater in COPD than in HSCT patients (p<0.0001). In the 1 year following the transplantation, sputum IL-6 and IL-8 did not differ any longer compared to healthy subjects. Overall in HSCT patients, sputum IL-8 and IL-6 correlated with sputum neutrophil counts (r=0.4, p<0.0001; r=0.42, p<0.0001, respectively). In conclusion, sputum IL-6 and IL-8 may play a role in neutrophilic airway inflammation seen in patients undergoing HSCT. [less ▲]

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See detailPlasma riche en plaquettes et lésions tendineuses
KAUX, Jean-François ULg; Drion, Pierre ULg; Croisier, Jean-Louis ULg et al

in Revue Médicale de Liège (2014), 69(Synthèse 2014), 72-77

Platelets contain growth factors released during their degranulation following activation. These growth factors promote tissue remodeling, wound healing and angiogenesis. Currently, the clinical effect of ... [more ▼]

Platelets contain growth factors released during their degranulation following activation. These growth factors promote tissue remodeling, wound healing and angiogenesis. Currently, the clinical effect of Platelet-Rich Plasma (PRP) is still discussed or even controversial. Our researches have evaluated the effectiveness of PRP on the healing of animal tendons and human suffering from chronic jumper's knee. [less ▲]

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See detailControl of molecular dynamics with zero-area fields. application to molecular orientation and photodissociation
Sugny, Dominique; Vranckx, Stéphane; Ndong, Mamadou et al

in Physical Review A (2014), 90

The constraint of time-integrated zero area on the laser field is a fundamental requirement, both theoretically and experimentally, in the control of molecular dynamics. By using techniques of local and ... [more ▼]

The constraint of time-integrated zero area on the laser field is a fundamental requirement, both theoretically and experimentally, in the control of molecular dynamics. By using techniques of local and optimal control theory, we show how to enforce this constraint in two benchmark control problems, namely, molecular orientation and photofragmentation. The origin and the physical implications for the dynamics of this zero-area control field are discussed. [less ▲]

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See detailBook Review: Ralf Brand and Sarah Fregonese 2013: The Radicals’ City: Urban Environment, Polarisation, Cohesion. Surrey: Ashgate.
Farah, Jihad ULg

in International Journal of Urban and Regional Research (2014), 38(6),

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See detailThe role of olfaction in wireworms: a review on foraging behavior and sensory apparatus
Barsics, Fanny ULg; Haubruge, Eric ULg; Francis, Frédéric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(4), 524-535

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use ... [more ▼]

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use biotic and abiotic signals to orientate towards target plant organs. Development of efficient techniques for implementation in integrated strategies relies upon improved knowledge of this process. In particular, an important step consists of elucidating the role of volatile organic compounds (VOC), emitted by belowground plant organs, in wireworm chemical ecology. This would have a positive impact on push-pull strategies and varietal selection developed against these insects. Literature In this work, we summarized the available data regarding wireworm foraging behavior as well as variables that should be considered when studying the potential role of plant-produced volatile semiochemicals. This includes CO2 gradients and other host-related cues, temperature, relative humidity and soil moisture, and wireworm physiological stage. We also review what is known of the sensory apparatus of wireworms, since this is involved in every step of the foraging process. Conclusion Some baseline data for studying VOC related wireworm foraging behavior exists. Using it as a tool in applied entomology should result in discovery of the semiochemicals that underpin trophic interactions involving these pests. However, most of the key pest species are not fully described with regards to the parameters detailed here. Obtaining accurate information to fill the current knowledge gaps will be needed in order to devise new integrated management strategies. [less ▲]

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See detailDépression et diabète de type 2. Analyse étiopathogènique d'une comorbidité fréquente
LUPPENS, David ULg; PIETTE, Catherine ULg; RADERMECKER, R.P et al

in Revue Médicale de Liège (2014), 69(11), 611-617

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See detailLa dépression à l'adolescence: Quels signes ? Quand s'inquiéter ?
Boulard, Aurore ULg

in Eduquer : Tribune Laïque (2014), 109

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See detailA new long-tailed bsal bird from the Lower Cretaceous of north-eastern China
Lefevre, Ulysse ULg; Hu, Dongyu; Escuillié, François et al

in Biological Journal of the Linnean Society (2014), 113(3), 790-804

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See detailMapping the electron energy in Jupiter’s aurora: Hubble spectral observations
Gérard, Jean-Claude ULg; Bonfond, Bertrand ULg; Grodent, Denis ULg et al

in Journal of Geophysical Research. Space Physics (2014), 119

Far ultraviolet spectral observations have been made with the Hubble Space Telescope in the time-tag mode using the Space Telescope Imaging Spectrograph (STIS) long slit. The telescope was slewed in such ... [more ▼]

Far ultraviolet spectral observations have been made with the Hubble Space Telescope in the time-tag mode using the Space Telescope Imaging Spectrograph (STIS) long slit. The telescope was slewed in such a way that the slit projection scanned from above the polar limb down to midlatitudes, allowing us to build up the first spectral maps of the FUV Jovian aurora. The shorter wavelengths are partly absorbed by the methane layer overlying part of the auroral emission layer. The long-wavelength intensity directly reflects the precipitated energy flux carried by the auroral electrons. Maps of the intensity ratio of the two spectral regions have been obtained by combining spectral emissions in two wavelength ranges. They show that the amount of absorption by methane varies significantly between the different components of the aurora and inside the main emission region. Some of the polar emissions are associated with the hardest precipitation, although the auroral regions of strong electron precipitation do not necessarily coincide with the highest electron energies. Outputs from an electron transport model are used to create maps of the distribution of the characteristic electron energies. Using model atmospheres adapted to auroral conditions, we conclude that electron energies range between a few tens to several hundred keV. Comparisons of derived energies are in general agreement with those calculated from magnetosphere-ionosphere coupling models, with values locally exceeding the standard model predictions. These results will provide useful input for three-dimensional modeling of the distribution of particle heat sources into the high-latitude Jovian upper atmosphere. [less ▲]

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See detailRaman hyperspectral imaging: a single tool to characterise pharmaceutical products
Netchacovitch, Lauranne ULg; De Bleye, Charlotte ULg; Chavez, Pierre-François ULg et al

in European Pharmaceutical Review (2014), 19(5), 8-11

Raman hyperspectral imaging is an increasingly used tool in the pharmaceutical field because it allows for the investigation of many characteristics on a solid sample. This paper delves into Raman ... [more ▼]

Raman hyperspectral imaging is an increasingly used tool in the pharmaceutical field because it allows for the investigation of many characteristics on a solid sample. This paper delves into Raman spectroscopy and imaging, including spectral and spatial information, and presents some applications of Raman hyperspectral imaging in the pharmaceutical field. [less ▲]

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See detailRecommandations européennes concernant la prise en charge de l'embolie pulmonaire.
MELISSOPOULOU, Maria ULg; ANCION, Arnaud ULg; LANCELLOTTI, Patrizio ULg

in Revue Medicale de Liege (2014), 69(11), 594-599

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See detailTrajectory-Based Supplementary Damping Control for Power System Electromechanical Oscillations
Wang, Da ULg; Glavic, Mevludin ULg; Wehenkel, Louis ULg

in IEEE Transactions on Power Systems (2014), 29(6), 2835-2845

This paper considers a trajectory-based approach to determine control signals superimposed to those of existing controllers so as to enhance the damping of electromechanical oscillations. This approach is ... [more ▼]

This paper considers a trajectory-based approach to determine control signals superimposed to those of existing controllers so as to enhance the damping of electromechanical oscillations. This approach is framed as a discrete-time, multi-step optimization problem which can be solved by model-based and/or by learning-based methods. This paper proposes to apply a model-free tree-based batch mode Reinforcement Learning (RL) algorithm to perform such a supplementary damping control based only on information collected from observed trajectories of the power system. This RL-based supplementary damping control scheme is first implemented on a single generator and then several possibilities are investigated for extending it to multiple generators. Simulations are carried out on a 16-generators medium size power system model, where also possible benefits of combining this RL-based control with Model Predictive Control (MPC) are assessed. [less ▲]

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See detailPoints d'appui
Jacquemain, Marc ULg

in SociologieS (2014)

L'article discute un grand résumé de Jan Spurk. Il met le doigt sur la contradiction dans ce "grand résumé" entre l'assomption que je le "je" est au coeur du capitalisme contemporain et le fait de confier ... [more ▼]

L'article discute un grand résumé de Jan Spurk. Il met le doigt sur la contradiction dans ce "grand résumé" entre l'assomption que je le "je" est au coeur du capitalisme contemporain et le fait de confier au sujet la tâche de l'émancipation de ce même capitalisme. Il propose de relever, dans différents courants de la littérature contemporaine de sciences sociales, les éléments qui plaident pour un "sujet" doté d'une capacité empirique de résistance au capitalisme. [less ▲]

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See detailStochastic modelling of reservoir sedimentation in a semi-arid watershed
Adam, Nicolas; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Water Resources Management (2014)

Sedimentation in large reservoirs is a major concern in semi-arid regions characterized by severe seasonal water scarcity. As a contribution to improved sediment management, this study analyses the real ... [more ▼]

Sedimentation in large reservoirs is a major concern in semi-arid regions characterized by severe seasonal water scarcity. As a contribution to improved sediment management, this study analyses the real case of the reservoir of Sidi Yacoub in the north of Algeria. First, a dynamic model of the reservoir was set up and used to estimate past water and sediment inflows (period 1990-2010) based on data recorded by the dam operator and measurements at a gauging station located downstream of the reservoir. Second, in a stochastic framework using the statistical characteristics of inflow and outflow discharges, a projection of future sedimentation was performed until 2030, assuming stationarity of the statistical distributions. Third, the model was used to investigate the influence of possible climate change and to quantify the positive effects of soil conservation measures upstream. [less ▲]

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See detailEstetrol attenuates neonatal hypoxic–ischemic brain injury
Tskitishvili, Ekaterine ULg; Nisolle, Michelle ULg; Munaut, Carine ULg et al

in Experimental Neurology (2014), 261

Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. It has important antioxidative activity. The aim ... [more ▼]

Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. It has important antioxidative activity. The aim of the present study was to define the importance of E4 in the attenuation of neonatal hypoxic-ischemic encephalopathy. Antioxidative effect of 650μM, 3.25mM and 6.5mM E4 on primary hippocampal cell cultures was studied before/after H202-induced oxidative stress. To examine oxidative stress and cell viability, lactate dehydrogenase activity and cell proliferation colorimetric assays were performed. To study the neuroprotective and therapeutic effects of E4 in vivo neonatal hypoxic-ischemic encephalopathy model of 7-day-old newborn rat pups was used. The neuroprotective and therapeutic effects of estetrol before/after hypoxic-ischemic insult was studied in 1mg/kg/day, 5mg/kg/day, 10mg/kg/day, 50mg/kg/day E4 pretreated/treated groups and compared with the sham and the vehicle treated groups. The body temperature of the rat pups was examined along with their body and brain weights. Brains were studied at the level of the hippocampus and cortex. Intact cell counting and expressions of microtubule-associated protein-2, doublecortin and vascular-endothelial growth factor were evaluated by histo- and immunohistochemistry. ELISAs were performed on blood samples to detect concentrations of S100B and glial fibrillary acidic protein as brain damage markers. This work reveals for the first time that E4 significantly decreases LDH activity and enhances cell proliferation in primary hippocampal neuronal cell cultures in vitro, and decreases the early gray matter loss and promotes neuro- and angiogenesis in vivo. [less ▲]

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See detailIl faut agir sur les structures et les pratiques
Lafontaine, Dominique ULg

in Wallonie : Revue du Conseil Economique et Social de la Région Wallonne (2014), (124), 16-19

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See detailRetrofitting the suburbs: Insulation, density, urban form and location
Marique, Anne-Françoise ULg; Reiter, Sigrid ULg

in Environmental management and sustainable development (2014), 3(2), 138-153

The effects of urban sprawl have been well documented, particularly regarding energy consumption. Suburban neighbourhoods are known to be energy inefficient and urban sprawl is considered as a major issue ... [more ▼]

The effects of urban sprawl have been well documented, particularly regarding energy consumption. Suburban neighbourhoods are known to be energy inefficient and urban sprawl is considered as a major issue for sustainable development. To improve the energy efficiency of existing suburban urban fabrics is a major challenge that must be addressed to favour a sustainability transition of our built environment. In this context, this paper aims at investigating several scenarios that could be developed to improve the sustainability of existing suburban neighbourhoods: three main types of scenarios (building insulation, density, and urban form) and twelve sub-scenarios, which are focused on the possible evolution of the existing suburban building stocks, are proposed. Quantitative methods developed in previous research are used to assess and compare building and transportation energy consumption of a representative suburban case study. This application aims at investigating two main research questions: (1) "how to intervene in suburban neighbourhoods?" and (2) «where to intervene?" The main results of this application, which are focused on energy efficiency, are then studied in a larger framework to highlight their opportunities and constraints. The main findings of the paper are that, beyond the traditional polarisation of the debates on the energy efficiency of our built environment between the “compact” and the “sprawled” city, a new pragmatic paradigm, which is focused on the smooth densification of existing suburban neighbourhoods, can make them evolve towards greater sustainability. [less ▲]

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See detailComment je traite … Recommandations pour surveiller et optimiser un traitement médicamenteux en cours
SCHEEN, André ULg

in Revue Médicale de Liège (2014), 69(11), 581-585

Any pharmacological treatment should ideally be effective and safe. The supervision of an ongoing therapy should control that individualized goals are reached while tolerance and safety are present. In ... [more ▼]

Any pharmacological treatment should ideally be effective and safe. The supervision of an ongoing therapy should control that individualized goals are reached while tolerance and safety are present. In case of not reaching the predefined objectives, the causes of failure should first be screened (for instance, exclusion of poor patient compliance), and the treatment should be then optimized : dose adjustment, add-on of another drug (if possible synergistic combination) and/or shift to a more effective pharmacological therapy. In some cases, therapeutic monitoring may be useful or even mandatory in order to better adjust drug dosing and thus guarantee both efficacy and safety. [less ▲]

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See detailValidation of SCIAMACHY HDO/H2O measurements using the TCCON and NDACC-MUSICA networks
Scheepmaker, R. A.; Frankenberg, C.; Deutscher, N. M. et al

in Atmospheric Measurement Techniques. Papers in Open Discussion (2014), 7(11), 11799--11851

Measurements of the atmospheric HDO/H2O ratio help us to better understand the hydrological cycle and improve models to correctly simulate tropospheric humidity and therefore climate change. We present an ... [more ▼]

Measurements of the atmospheric HDO/H2O ratio help us to better understand the hydrological cycle and improve models to correctly simulate tropospheric humidity and therefore climate change. We present an updated version of the column-averaged HDO/H2O ratio dataset from the SCanning Imaging Absorption spectroMeter for Atmospheric CHartographY (SCIAMACHY). The dataset is extended with two additional years, now covering 2003–2007, and is validated against co-located ground-based total column delta-D measurements from Fourier-Transform Spectrometers (FTS) of the Total Carbon Column Observing Network (TCCON) and the Network for the Detection of Atmospheric Composition Change (NDACC, produced within the framework of the MUSICA project). Even though the time overlap between the available data is not yet ideal, we determined a mean negative bias in SCIAMACHY delta-D of -35±30‰ compared to TCCON and -69±15‰ compared to MUSICA (the uncertainty indicating the station-to-station standard deviation). The bias shows a latitudinal dependency, being largest (about -60 to -80‰) at the highest latitudes and smallest (about -20 to -30‰) at the lowest latitudes. We have tested the impact of an offset correction to the SCIAMACHY HDO and H2O columns. This correction leads to a humidity and latitude dependent shift in delta-D and an improvement of the bias by 27 ‰, although it does not lead to an improved correlation with the FTS measurements nor to a strong reduction of the latitudinal dependency of the bias. The correction might be an improvement for dry, high-altitude areas, such as the Tibetan Plateau and the Andes region. For these areas, however, validation is currently impossible due to a lack of ground stations. The mean standard deviation of single-sounding SCIAMACHY–FTS differences is ~115 ‰, which is reduced by a factor ~2 when we consider monthly means. When we relax the strict matching of individual measurements and focus on the mean seasonalities using all available FTS data, we find that the correlation coefficients between SCIAMACHY and the FTS networks improve from 0.2 to 0.7–0.8. Certain ground stations show a clear asymmetry in delta-D during the transition from the dry to the wet season and back, which is also detected by SCIAMACHY. This asymmetry points to a transition in the source region temperature or location of the water vapor, and shows the added information that HDO/H2O measurements provide, if used in combination with variations in humidity. [less ▲]

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See detailInfinite self-shuffling words
Charlier, Emilie ULg; Kamae, Teturo; Puzynina, Svetlana et al

in Journal of Combinatorial Theory - Series A (2014), 128

In this paper we introduce and study a new property of infinite words: An infinite word x, with values in a finite set A, is said to be k-self-shuffling (k≥2) if there exists a shuffle of k copies of x ... [more ▼]

In this paper we introduce and study a new property of infinite words: An infinite word x, with values in a finite set A, is said to be k-self-shuffling (k≥2) if there exists a shuffle of k copies of x which produces x. We are particularly interested in the case k=2, in which case we say x is self-shuffling. This property of infinite words is shown to be independent of the complexity of the word as measured by the number of distinct factors of each length. Examples exist from bounded to full complexity. It is also an intrinsic property of the word and not of its language (set of factors). For instance, every aperiodic word contains a non-self-shuffling word in its shift orbit closure. While the property of being self-shuffling is a relatively strong condition, many important words arising in the area of symbolic dynamics are verified to be self-shuffling. They include for instance the Thue–Morse word fixed by the morphism 0↦01, 1↦10. As another example we show that all Sturmian words of intercept 0<ρ<1 are self-shuffling (while those of intercept ρ=0 are not). Our characterization of self-shuffling Sturmian words can be interpreted arithmetically in terms of a dynamical embedding and defines an arithmetic process we call the stepping stone model. One important feature of self-shuffling words stems from their morphic invariance: The morphic image of a self-shuffling word is self-shuffling. This provides a useful tool for showing that one word is not the morphic image of another. In addition to its morphic invariance, this new notion has other unexpected applications particularly in the area of substitutive dynamical systems. For example, as a consequence of our characterization of self-shuffling Sturmian words, we recover a number theoretic result, originally due to Yasutomi, on a classification of pure morphic Sturmian words in the orbit of the characteristic. [less ▲]

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See detailDe l’usage des programmes électoraux. Compétition sur enjeux et attribution des compétences au sein du gouvernement wallon 2014-2019
Piet, Grégory ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 3

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See detailAn inverse modelling approach to estimate the hygric parameters of clay-based masonry during a Moisture Buffer Value test
Dubois, Samuel ULg; McGregor, Fionn; Evrard, Arnaud et al

in Building & Environment (2014), 81

This paper presents an inverse modelling approach for parameter estimation of a model dedicated to the description of moisture mass transfer in porous hygroscopic building materials. The hygric behaviour ... [more ▼]

This paper presents an inverse modelling approach for parameter estimation of a model dedicated to the description of moisture mass transfer in porous hygroscopic building materials. The hygric behaviour of unfired clay-based masonry samples is specifically studied here and the Moisture Buffer Value (MBV) protocol is proposed as a data source from which it is possible to estimate several parameters at once. Those include materials properties and experimental parameters. For this purpose, the mass of two clay samples with different compositions is continuously monitored during several consecutive humidity cycles in isothermal conditions. Independently of these dynamic experimental tests, their moisture storage and transport parameters are measured with standard steady-state methods. A simple moisture transfer model developed in COMSOL Multiphysics is used to predict the moisture uptake/release behaviour during the MBV tests. The set of model parameters values that minimizes the difference between simulated and experimental results is then automatically estimated using an inverse modelling algorithm based on Bayesian techniques. For materials properties, the optimized parameters values are compared to values that were experimentally measured in steady state. And because a precise understanding of parameters is needed to assess the confidence in the inverse modelling results, a sensitivity analysis of the model is also provided. [less ▲]

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See detailVegetative Regeneration Capacities of Five Ornamental Plant Invaders After Shredding
Monty, Arnaud ULg; Eugène, Marie; Mahy, Grégory ULg

in Environmental Management (2014)

Vegetation management often involves shredding to dispose of cut plant material or to destroy the vegetation itself. In the case of invasive plants, this can represent an environmental risk if the ... [more ▼]

Vegetation management often involves shredding to dispose of cut plant material or to destroy the vegetation itself. In the case of invasive plants, this can represent an environmental risk if the shredded material exhibits vegetative regeneration capacities. We tested the effect of shredding on aboveground and below-ground vegetative material of five ornamental widespread invaders in Western Europe that are likely to be managed by cutting and shredding techniques: Buddleja davidii (butterfly bush, Scrophulariaceae), Fallopia japonica (Japanese knotweed, Polygonaceae), Spiraea x billardii He´rincq (Billard’s bridewort, Rosaceae), Solidago gigantea (giant goldenrod, Asteraceae), and Rhus typhina L. (staghorn sumac, Anacardiaceae). We looked at signs of vegetative regeneration and biomass production, and analyzed the data with respect to the season of plant cutting (spring vs summer), the type of plant material (aboveground vs below-ground), and the shredding treatment (shredded vs control). All species were capable of vegetative regeneration, especially the belowground material. We found differences among species, but the regeneration potential was generally still present after shredding despite a reduction of growth rates. Although it should not be excluded in all cases (e.g., destruction of giant goldenrod and staghorn sumac aboveground material), the use of a shredder to destroy woody alien plant material cannot be considered as a general management option without significant environmental risk. [less ▲]

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See detailIsotopic tracing of sediment components that are assimilated by epibiontic juveniles of Holothuria scabra (Holothuroidea)
Plotieau, Thomas; Lepoint, Gilles ULg; Lavitra, Thiery et al

in Journal of the Marine Biological Association of the United Kingdom (2014), 94(7), 1485-1490

Despite H. scabra’s wide distribution and status as one of the best candidates for sustaining the development of tropical sea cucumber aquaculture, very few data are available regarding the organic ... [more ▼]

Despite H. scabra’s wide distribution and status as one of the best candidates for sustaining the development of tropical sea cucumber aquaculture, very few data are available regarding the organic fraction it assimilates in practice. In this study we report experimental results where H. scabra’s diet was supplemented with various 15N-labelled organic fractions of sediment. We used juveniles weighing between 38- 88 mg at the beginning of the experiment (ca. 2 cm long and 30 days old). Their growth was measured over a four week period and their 15N composition recorded. The results showed that H. scabra juveniles assimilated all added organic components from both dissolved and particulate fractions of the sediment. Bacteria seem to be an important food source for juveniles, even more so than microphytobenthos (diatoms). [less ▲]

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See detailImprints of the quasar structure in time-delay light curves: Microlensing-aided reverberation mapping
Sluse, Dominique ULg; Tewes, M.

in Astronomy and Astrophysics (2014), 571(A60), 10

Owing to the advent of large area photometric surveys, the possibility to use broad band photometric data, instead of spectra, to measure the size of the broad line region of active galactic nuclei, has ... [more ▼]

Owing to the advent of large area photometric surveys, the possibility to use broad band photometric data, instead of spectra, to measure the size of the broad line region of active galactic nuclei, has raised a large interest. We describe here a new method using time-delay lensed quasars where one or several images are affected by microlensing due to stars in the lensing galaxy. Because microlensing decreases (or increases) the flux of the continuum compared to the broad line region, it changes the contrast between these two emission components. We show that this effect can be used to effectively disentangle the intrinsic variability of those two regions, offering the opportunity to perform reverberation mapping based on single band photometric data. Based on simulated light curves generated using a damped random walk model of quasar variability, we show that measurement of the size of the broad line region can be achieved using this method, provided one spectrum has been obtained independently during the monitoring. This method is complementary to photometric reverberation mapping and could also be extended to multi-band data. Because the effect described above produces a variability pattern in difference light curves between pairs of lensed images which is correlated with the time-lagged continuum variability, it can potentially produce systematic errors in measurement of time delays between pairs of lensed images. Simple simulations indicate that time-delay measurement techniques which use a sufficiently flexible model for the extrinsic variability are not affected by this effect and produce accurate time delays. [less ▲]

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See detailTendon et tendinopathie
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

in Journal de Traumatologie du Sport (2014), 31(4), 235-240

The tendon, connective fibrous tissue, mechanically responsible for the transmission of strength of muscles to bones, is a dynamic entity which, according to the constraints, restructures permanently and ... [more ▼]

The tendon, connective fibrous tissue, mechanically responsible for the transmission of strength of muscles to bones, is a dynamic entity which, according to the constraints, restructures permanently and, thanks to various metabolic and mechanical changes. This review describes the histology, vascularization and innervation of the healthy tendon. In addition, the biomechanics and tendinous physiological responses, as well as the pathophysiology of tendinopathy are exposed. © 2014 Elsevier Masson SAS. [less ▲]

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See detailPractical aspects of genome-wide association interaction analysis.
Gusareva, Elena ULg; Van Steen, Kristel ULg

in Human Genetics (2014), 133(11), 1343-58

Large-scale epistasis studies can give new clues to system-level genetic mechanisms and a better understanding of the underlying biology of human complex disease traits. Though many novel methods have ... [more ▼]

Large-scale epistasis studies can give new clues to system-level genetic mechanisms and a better understanding of the underlying biology of human complex disease traits. Though many novel methods have been proposed to carry out such studies, so far only a few of them have demonstrated replicable results. Here, we propose a minimal protocol for genome-wide association interaction (GWAI) analysis to identify gene–gene interactions from large-scale genomic data. The different steps of the developed protocol are discussed and motivated, and encompass interaction screening in a hypothesis-free and hypothesisdriven manner. In particular, we examine a wide range of aspects related to epistasis discovery in the context of complex traits in humans, hereby giving practical recommendations for data quality control, variant selection or prioritization strategies and analytic tools, replication and meta-analysis, biological validation of statistical findings and other related aspects. The minimal protocol provides guidelines and attention points for anyone involved in GWAI analysis and aims to enhance the biological relevance of GWAI findings. At the same time, the protocol improves a better assessment of strengths and weaknesses of published GWAI methodologies. [less ▲]

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See detailTwo new aromadendrane sesquiterpenes from the stem bark of Alafia multiflora
Tchinda Tiabou, Alembert ULg; Tsala, David E.; Nnanga, Nga et al

in Natural Product Communications (2014), 9(12), 1673-1675

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See detailLa strega, la contessa, il ragno. Sciascia e i differenziali della storia
Fichera, Gabriele ULg

in Todo modo. Rivista internazionale di studi sciasciani (2014), Anno IV

Analysing 1912 + 1, this essay sets out to demonstrate the ways in which Sciascia’s blending of fiction and history addresses the contentious issue of identifying truth. It examines the intricate ... [more ▼]

Analysing 1912 + 1, this essay sets out to demonstrate the ways in which Sciascia’s blending of fiction and history addresses the contentious issue of identifying truth. It examines the intricate philosophical links between freedom and necessity, and compares Sciascia’s writing with that of authors who were dear to him, such as Diderot, Manzoni, Tolstoj and Savinio. [less ▲]

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See detailLa prothèse valvulaire idéale n’existe toujours pas. Quels facteurs entrent en compte pour orienter les choix d’une valve mécanique ou biologique ?
GREGOIRE, Céline ULg; Nellessen, Eric; Defraigne, Jean-Olivier ULg et al

in Revue Médicale de Liège (2014), 69(11), 600-604

The prevalence of valvular heart diseases reaches 2.5% in the overall population. Aortic valve replacement is one of the most common surgical procedures. We report the story of a female patient whose ... [more ▼]

The prevalence of valvular heart diseases reaches 2.5% in the overall population. Aortic valve replacement is one of the most common surgical procedures. We report the story of a female patient whose aortic mechanical valve, implanted at the age of 54 years at the time of a mitral valve repair surgery, had to be replaced 14 years later, due to the development of a subvalvular pannus narrowing the valvular orifice. We use this clinical story to compare the advantages and disadvantages of repair surgery and valve replacement with a biological or mechanical prosthesis, and summarize the latest evidence for the choice of the most adequate prosthesis for a particular patient’s profile. [less ▲]

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See detail"If it helps, i'll carry on" : Factors supporting the Participation of Native and Immigrants Youth in Belgium and Germany
Born, Michel ULg; Marzana, Daniela; Alfieri, Sara et al

in Journal of psychology: Interdisciplinary and Applied (2014), 148

This article is looking into some factors for Civic Participation and the intention to continue to participate among local (Study I) and immigrant (Study II) young people living in Belgium and Germany ... [more ▼]

This article is looking into some factors for Civic Participation and the intention to continue to participate among local (Study I) and immigrant (Study II) young people living in Belgium and Germany. The results provide the same results in the immigrant and in the native group. Once observable demographic factors are controlled, many of the differences found in other researches (immigrant youth less committed or subjected to other paths of participation) disappear. Applicative repercussions are discussed. [less ▲]

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See detailAu cœur de la réforme des soins de santé mentale en Belgique : les coordinateurs de réseau
Thunus, Sophie ULg; Lorquet, Nadège ULg

in SociologieS (2014)

Inside the Belgian reform of mental health care delivery: network coordinators This article analyses the Belgian reform of mental health care delivery as a two steps-translation (Callon 1986): the ... [more ▼]

Inside the Belgian reform of mental health care delivery: network coordinators This article analyses the Belgian reform of mental health care delivery as a two steps-translation (Callon 1986): the problematization – the devising of a new mental health care model by policy makers, and the interessement – through which “local coordinators” tried to interest local actors to the new model. Based on empirical data, two evidences are stressed: the coordination function is conceived in different ways, ranging from intermediaries to mediators; and the interessement is influenced by systems of concrete action (Friedberg, 1997). Thus, it is argued that in case where translators are appointed to interest local actors to a problematization from the policy arena, their performance is better appraised by considering their commitment to behave as faithful intermediaries or as strategic mediators, and the informal games regulating their system of action. [less ▲]

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See detailLa représentation commerciale comme objet principal du contrat
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2014), (2014/35),

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See detailPlutella xylostella (L.) infestations at varying temperatures induce the emission of specific volatile blends by Arabidopsis thaliana (L.) Heynh
Hien, Truong Thi Dieu ULg; Delory, Benjamin ULg; Brostaux, Yves ULg et al

in Plant Signaling & Behavior (2014)

The effect of combined abiotic and biotic factors on plant volatile organic compound (VOC) emissions is poorly understood. This study evaluated the VOC emissions produced by Arabidopsis thaliana (L.) Col ... [more ▼]

The effect of combined abiotic and biotic factors on plant volatile organic compound (VOC) emissions is poorly understood. This study evaluated the VOC emissions produced by Arabidopsis thaliana (L.) Col-0 subjected to three temperature regimes (17, 22, and 27 °C) in the presence and absence of Plutella xylostella larvae over two time intervals (0–4 and 4–8 h), in comparison to control plants. The analyses of VOCs emitted by Arabidopsis plants were made by headspace solid phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS). It was found that certain volatile groups (e.g., alcohols, ketones, aldehydes, and terpenes) are induced by both single factors (temperature or larval infestation) and combined factors (temperature and larvae interactions), whereas other volatile groups (e.g., isothiocyanates [ITCs] and nitrile) were specific to the experimental conditions. ITCs (mainly 4-methylpentyl isothiocyanate) were emitted from plants subjected to larval infestation at 17 and 27 °C after the two time intervals. The proportions of sulfides (mainly dimethyl disulfide) and 4-(methylthio) butanenitrile were significantly higher on herbivore-infested plants at 22 °C compared to the other treatments. Overall, our findings indicate that changes in all experimental conditions caused significant changes to the VOC emissions of Arabidopsis plants. Therefore, the interaction between temperature and larval feeding may represent an important factor determining the variability of volatile emissions by plants subjected to multiple simultaneous factors. [less ▲]

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See detailInjury Risk Assessment of Non-Lethal Projectile Head Impacts
Oukara, Amar ULg; Robbe, Cyril; Nsiampa, Nestor et al

in The Open Biomedical Engineering Journal (2014), 8(2014), 75-83

Kinetic energy non-lethal projectiles are used to impart sufficient effect onto a person in order to deter uncivil or hazardous behavior with a low probability of permanent injury. Since their first use ... [more ▼]

Kinetic energy non-lethal projectiles are used to impart sufficient effect onto a person in order to deter uncivil or hazardous behavior with a low probability of permanent injury. Since their first use, real cases indicate that the injuries inflicted by such projectiles may be irreversible and sometimes lead to death, especially for the head impacts. Given the high velocities and the low masses involved in such impacts, the assessment approaches proposed in automotive crash tests and sports may not be appropriate. Therefore, there is a need of a specific approach to assess the lethality of these projectiles. In this framework, some recent research data referred in this article as “force wall approach” suggest the use of three lesional thresholds (unconsciousness, meningeal damages and bone damages) that depend on the intracranial pressure. Three corresponding critical impact forces are determined for a reference projectile. Based on the principle that equal rigid wall maximal impact forces will produce equal damage on the head, these limits can be determined for any other projectile. In order to validate the consistence of this innovative method, it is necessary to compare the results with other existing assessment methods. This paper proposes a comparison between the “force wall approach” and two different head models. The first one is a numerical model (Strasbourg University Finite Element Head Model-SUFEHM) from Strasbourg University; the second one is a mechanical surrogate (Ballistics Load Sensing Headform-BLSH) from Biokinetics. [less ▲]

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See detailCapacitated vehicle routing problem with sequence- based pallet loading and axle weight constraints
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in EURO Journal on Transportation and Logistics (2014)

In this paper, we introduce and study the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints. To the best of our knowledge, it is the first time that axle ... [more ▼]

In this paper, we introduce and study the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints. To the best of our knowledge, it is the first time that axle weight restrictions are incorporated in a vehicle routing model. The aim of this paper is to demonstrate that incorporating axle weight restrictions in a vehicle routing model is possible and necessary for a feasible route planning. Axle weight limits impose a great challenge for transportation companies. Trucks with overloaded axles represent a significant threat for traffic safety and may cause serious damage to the road surface. Transporters face high fines when violating these limits. A mixed integer linear programming formulation for the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints is provided. Results of the model are compared to the results of the model without axle weight restrictions. Computational experiments demonstrate that the model performs adequately and that the integration of axle weight constraints in vehicle routing models is required for a feasible route planning. [less ▲]

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See detailLa lutte contre les moustiques (Diptera: Culicidae): diversité des approches et application du contrôle biologique
Bawin, Thomas ULg; Seye, Fawrou; Boukraa, Slimane ULg et al

in Canadian Entomologist (2014)

Many mosquito (Diptera: Culicidae) species are zoonotic vectors responsible for numerous infectious diseases of medical and veterinary importance. Currently, changes in the vectors’ geographical ... [more ▼]

Many mosquito (Diptera: Culicidae) species are zoonotic vectors responsible for numerous infectious diseases of medical and veterinary importance. Currently, changes in the vectors’ geographical distribution induced chiefly by anthropogenic factors are accompanied by emerging and reemerging infectious diseases in Europe and North America. Since the advent of synthetic insecticides during the Second World War, mosquitoes are the object of considerably expanded and deepened research. In an integrated pest management context, means of control are now mainly classified as: (1) environmental management and physical control, (2) chemical control, (3) genetic control, and (4) biological control by means of entomophagous predators and entomopathogenic microorganisms. In this context, these last have significant potential because of their ability to infect and kill their host with more or less targeted selectivity. This article proposes to emphasize biological control among other techniques in mosquito control, and to assess the potential and the opportunities offered by entomopathogenic bacteria, viruses and fungi. Finally, their use as biopesticides is discussed. [less ▲]

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See detailPiezoelectric vibration damping using resonant shunt circuits: an exact solution
Soltani, Payam ULg; Kerschen, Gaëtan ULg; Tondeau, Gilles et al

in Smart Materials & Structures (2014), 23

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See detailRetrievals of formaldehyde from ground-based FTIR and MAX-DOAS observations at the Jungfraujoch station and comparisons with GEOS-Chem and IMAGES model simulations
Franco, Bruno ULg; Hendrick, François; Van Roozendael, Michel et al

in Atmospheric Measurement Techniques. Papers in Open Discussion (2014), 7

As a ubiquitous product of the oxidation of many Volatile Organic Compounds (VOCs), formaldehyde (HCHO) plays a key role as a short-lived and reactive intermediate in the atmospheric photo-oxidation ... [more ▼]

As a ubiquitous product of the oxidation of many Volatile Organic Compounds (VOCs), formaldehyde (HCHO) plays a key role as a short-lived and reactive intermediate in the atmospheric photo-oxidation pathways leading to the formation of tropospheric ozone and secondary organic aerosols. In this study, HCHO profiles have been successfully retrieved from ground-based Fourier Transform Infrared (FTIR) solar spectra and UV-Visible Multi-AXis Differential Optical Absorption Spectroscopy (MAX-DOAS) scans recorded during the July 2010–December 2012 time period at the Jungfraujoch station (Swiss Alps, 46.5 N, 8.0 E, 3580ma.s.l.). Analysis of the retrieved products has revealed different vertical sensitivity between both remote sensing techniques. Furthermore, HCHO amounts simulated by two state-of-the-art Chemical Transport Models (CTMs), GEOS-Chem and IMAGESv2, have been compared to FTIR total columns and MAX-DOAS 3.6–8 km partial columns, accounting for the respective vertical resolution of each ground-based instrument. Using the CTMs outputs as intermediate, FTIR and MAX-DOAS retrievals have shown consistent seasonal modulations of HCHO throughout the investigated period, characterized by summertime maximum and wintertime minimum. Such comparisons have also highlighted that FTIR and MAX-DOAS provide complementary products for the HCHO retrieval above the Jungfraujoch station. [less ▲]

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See detailSensitivity of Greenland Ice Sheet surface mass balance to perturbations in sea surface temperature and sea ice cover: a study with the regional climate model MAR
Noel, Brice; Fettweis, Xavier ULg; van de Berg, W.J. et al

in Cryosphere (The) (2014), 8

During recent summers (2007–2012), several surface melt records were broken over the Greenland Ice Sheet (GrIS). The extreme summer melt resulted in part from a persistent negative phase of the North ... [more ▼]

During recent summers (2007–2012), several surface melt records were broken over the Greenland Ice Sheet (GrIS). The extreme summer melt resulted in part from a persistent negative phase of the North Atlantic Oscillation (NAO), favoring warmer atmospheric conditions than normal over the GrIS. Simultaneously, large anomalies in sea ice cover (SIC) and sea surface temperature (SST) were observed in the North Atlantic, suggesting a possible connection. To assess the direct impact of 2007–2012 SIC and SST anomalies on GrIS surface mass balance (SMB), a set of sensitivity experiments was carried out with the regional climate model MAR forced by ERA-Interim. These simulations suggest that perturbations in SST and SIC in the seas surrounding Greenland do not considerably impact GrIS SMB, as a result of the katabatic wind blocking effect. These offshore-directed winds prevent oceanic near-surface air, influenced by SIC and SST anomalies, from penetrating far inland. Therefore, the ice sheet SMB response is restricted to coastal regions, where katabatic winds cease. A topic for further investigation is how anomalies in SIC and SST might have indirectly affected the surface melt by changing the general circulation in the North Atlantic region, hence favoring more frequent warm air advection towards the GrIS. [less ▲]

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See detailCombined holography and thermography in a single sensor through image-plane holography at thermal infrared wavelengths
Georges, Marc ULg; Vandenrijt, Jean-François ULg; Thizy, Cédric ULg et al

in Optics Express (2014), 22(21), 25517-25529

Holographic interferometry in the thermal wavelengths range, combining a CO2 laser and digital hologram recording with a microbolometer array based camera, allows simultaneously capturing temperature and ... [more ▼]

Holographic interferometry in the thermal wavelengths range, combining a CO2 laser and digital hologram recording with a microbolometer array based camera, allows simultaneously capturing temperature and surface shape information about objects. This is due to the fact that the holograms are affected by the thermal background emitted by objects at room temperature. We explain the setup and the processing of data which allows decoupling the two types of information. This natural data fusion can be advantageously used in a variety of nondestructive testing applications. [less ▲]

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See detailProbabilistic Assessment of Lifetime of Low-Earth-Orbit Spacecraft: Uncertainty Propagation and Sensitivity Analysis
Dell'Elce, Lamberto ULg; Kerschen, Gaëtan ULg

in Journal of Guidance Control & Dynamics (2014)

This paper is devoted to the probabilistic uncertainty quantification of orbital lifetime estimation of low-altitude satellites. Specifically, given a detailed characterization of the dominant sources of ... [more ▼]

This paper is devoted to the probabilistic uncertainty quantification of orbital lifetime estimation of low-altitude satellites. Specifically, given a detailed characterization of the dominant sources of uncertainty, we map this input into a probabilistic characterization of the orbital lifetime through orbital propagation. Standard Monte Carlo propagation is first considered. The concept of drag correction is then introduced to facilitate the use of polynomial chaos expansions and to make uncertainty propagation computationally effective. Finally, the obtained probabilistic model is exploited to carry out stochastic sensitivity analyses, which in turn allow gaining insight into the impact uncertainties have on orbital lifetime. The proposed developments are illustrated using one CubeSat of the QB50 constellation. [less ▲]

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See detailSeasonal variations of wild boar Sus scrofa distribution in agricultural landscapes: a species distribution modelling approach
Morelle, Kevin ULg; Lejeune, Philippe ULg

in European Journal of Wildlife Research (2014)

Seasonal changes in the distribution of animals can have an important impact on the ecosystem. In agricultural landscapes, the seasonal movement of the wild boar Sus scrofa towards field crops often ... [more ▼]

Seasonal changes in the distribution of animals can have an important impact on the ecosystem. In agricultural landscapes, the seasonal movement of the wild boar Sus scrofa towards field crops often results in damages and makes control of the population difficult. The plasticity of the species to cope with different habitats is largely proven, but the environmental and human drivers of this seasonal habitat shift at the population scale remain largely unknown. Using MaxEnt and two seasonally distinct presence datasets, we contrasted the distribution of wild boar in southern Belgium during the growing and hunting seasons to (i) analyse seasonal drivers of the distribution and (ii) forecast the potential spread of the species north to its current distribution. We demonstrated that during the growing season, wild boar range almost double, owing to the cover and food provided by agricultural areas, thereby enhancing the movement and spread of the species. We found that the seasonal distribution of wild boar in agricultural lands is mostly influenced by the search for cover and food provided alternatively by forest and field crops. Interestingly, it seems that this search for cover operates under the constraint of a threshold distance. Our results indeed reveal an increased probability of presence not only in the vicinity of forests but also above a threshold distance of 865 m from the forest edge, suggesting that wild boar can overcome the dependence to forest cover. The forecast distribution of wild boar highlighted a potential increase of the current range into suitable habitat between 63 and 168 km2. To counteract the potential spread of the species into agricultural habitats and the consecutive damages, we insist on the need for the development of integrated management strategies, combining land use spatial configuration and wild boar spatial behaviour. [less ▲]

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See detailRèglements de juges : conséquences sur la peine et sur la saisine du juge de renvoi
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2014)

Le prévenu qui après avoir été condamné par défaut et sur opposition interjette seul appel de cette dernière décision ne peut voir sa situation aggravée quand bien même la juridiction d’appel s’est ... [more ▼]

Le prévenu qui après avoir été condamné par défaut et sur opposition interjette seul appel de cette dernière décision ne peut voir sa situation aggravée quand bien même la juridiction d’appel s’est déclarée incompétente provoquant de la sorte un règlement de juges qui se résout par son renvoi devant la cour d’assises. [less ▲]

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See detailP2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice
Darbousset, Roxane; Delierneux, Céline ULg; Mezouar, Soraya et al

in Blood (2014), 124

Adenosine Triphosphate (ATP) and its metabolite, adenosine, are key regulators of polymorphonuclear neutrophils (PMNs) functions. PMNs have recently been implicated in the initiation of thrombosis. We ... [more ▼]

Adenosine Triphosphate (ATP) and its metabolite, adenosine, are key regulators of polymorphonuclear neutrophils (PMNs) functions. PMNs have recently been implicated in the initiation of thrombosis. We investigated the role of ATP and adenosine in PMN activation and recruitment at the site of endothelial injury. Following binding to the injured vessel wall, PMNs are activated and release elastase. The recruitment of PMNs and the subsequent fibrin generation and thrombus formation are strongly affected in mice deficient in the P2X1-ATP receptor and in wild-type mice treated with CGS 21680, an agonist of the A2A adenosine receptor or NF449 a P2X1 antagonist. Infusion of wild-type PMNs into P2X1-deficient mice increases fibrin generation but not thrombus formation. Restoration of thrombosis requires infusion of both platelets and PMNs from wild-type mice. In vitro, ATP activates PMNs, whereas CGS 21680 prevents their binding to activated endothelial cells. These data indicate that ATP contributes to PMN activation leading to their adhesion at the site of laser-induced endothelial injury, a necessary step leading to the generation of fibrin and subsequent platelet-dependent thrombus formation. Altogether, our study identifies previously unknown mechanisms by which ATP and adenosine are key molecules involved in thrombosis by regulating the activation state of PMNs. [less ▲]

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See detailEffects of Size and Dispersity of Microcrystalline Celluloses on Size, Structure and Stability of Nanocrystalline Celluloses Extracted by Acid Hydrolysis
Qi, Liu; Weiping, Hao; Yongguang, Yang et al

in Nano LIFE (2014), 4(4),

Nanocrystalline celluloses (NCCs) were separated from four commercial microcrystalline celluloses (MCCs) by an acid hydrolysis–sonication treatment. Transmission electron microscopy (TEM), atomic force ... [more ▼]

Nanocrystalline celluloses (NCCs) were separated from four commercial microcrystalline celluloses (MCCs) by an acid hydrolysis–sonication treatment. Transmission electron microscopy (TEM), atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectrum, X-ray di®raction (XRD) and thermogravimetric analysis (TGA) were conducted to investigate the NCCs. MCCs with di®erent morphologies and particle sizes showed di®erent aggregation degrees. The aggregation of MCCs followed the order MCC1 > MCC3 > MCC2 > MCC4, which is the same order of the heights of the resulting NCCs. The best uniformity and thermal stability were characterized for NCC3, which was produced by MCC3 with smallest original particle size and good dispersity among the four MCCs. This result suggests that both the original particle size and dispersity of MCCs had signi¯cant e®ects on separated NCCs. [less ▲]

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See detailA closer look at the low frequency dynamics of vortex matter
Raes, Bart; de Souza Silva, Clecio C.; Silhanek, Alejandro ULg et al

in Physical Review. B : Condensed Matter (2014), 90

Using scanning susceptibility microscopy, we shed new light on the dynamics of individual superconducting vortices and examine the hypotheses of the phenomenological models traditionally used to explain ... [more ▼]

Using scanning susceptibility microscopy, we shed new light on the dynamics of individual superconducting vortices and examine the hypotheses of the phenomenological models traditionally used to explain the macroscopic ac electromagnetic properties of superconductors. The measurements, carried out on a 2H-NbSe2 single crystal at relatively high temperature T = 6.8 K, show a linear amplitude dependence of the global ac-susceptibility for excitation amplitudes between 0.3 and 2.6 Oe. We observe that the low amplitude response, typically attributed to the oscillation of vortices in a potential well defi ned by a single, relaxing, Labusch constant, actually corresponds to strongly non-uniform vortex shaking. This is particularly pronounced in the fi eld-cooled disordered phase, which undergoes a dynamic reorganization above 0.8 Oe as evidenced by the healing of lattice defects and a more uniform oscillation of vortices. These observations are corroborated by molecular dynamics simulations when choosing the microscopic input parameters from the experiments. The theoretical simulations allow us to reconstruct the vortex trajectories providing deeper insight in the thermally induced hopping dynamics and the vortex lattice reordering. [less ▲]

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See detailThe use of Ion Mobility Mass Spectrometry for isomer composition determination extracted from Se-rich yeast
Far, Johann ULg; Delvaux, Cédric ULg; Kune, Christopher ULg et al

in Analytical Chemistry (2014), just accepted

The isomer ratio determination of a selenium-containing metabolite produced by Se-rich yeast was performed. Electrospray Ionization and Ion Mobility Mass Spectrometry (IM-MS) were unsuccessfully used in ... [more ▼]

The isomer ratio determination of a selenium-containing metabolite produced by Se-rich yeast was performed. Electrospray Ionization and Ion Mobility Mass Spectrometry (IM-MS) were unsuccessfully used in order to resolve the isomers according to their Collisional Cross Section (CCS) difference. The isomer ratio determination of 2,3-dihydroxypropionylselenocystathionine was performed after multidimensional liquid chromatography preconcentration from a water extract of Se-rich yeast using preparative size exclusion, anion exchange and capillary reverse phase columns coupled to IM-MS. 4’-nitrobenzo-15-crown-5 ether, a Selective Shift Reagent (SSR), was added after the last chromatographic dimension in order to specifically increase the CCS of one of the isomers by the formation of a stable host-guest system with the crown-ether . Both isomers were consequently fully resolved by IM-MS and the relative ratio of the isomers was determined: 11-13% and 87-89%. The present data compared favorably with literature to support the analytical strategy despite the lack of authentic standard for method validation. In addition, computational chemistry methods were successfully applied to design the SSR and to support the experimental data. [less ▲]

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See detailThe open-air site of Tolbor 16 (Northern Mongolia): preliminary results and perspectives
Zwyns, N.; Gladyshev; Gunchinsuren, B. et al

in Quaternary International (2014), 347

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See detailA facile and fast electrochemical route to produce functional few-layer graphene sheets for lithium battery anode application
Ouhib, Farid ULg; Aqil, Abdelhafid ULg; Thomassin, Jean-Michel ULg et al

in Journal of Materials Chemistry A (2014), 2(37), 15298-15302

A simple approach for the production of polymer functionalized graphene nanosheets is reported. The resulting polyacrylonitrile chemisorbed on graphene sheets is made of 1 to 2 layers, with a large ... [more ▼]

A simple approach for the production of polymer functionalized graphene nanosheets is reported. The resulting polyacrylonitrile chemisorbed on graphene sheets is made of 1 to 2 layers, with a large majority of graphene single-layers. This novel functionalized graphene exhibits good cycling stability as an anode in Li-ion batteries without a conductive additive or binder. [less ▲]

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See detailClassical analogy for the deflection of flux avalanches by a metallic layer
Brisbois, Jérémy ULg; Vanderheyden, Benoît ULg; Colauto, Fabiano et al

in New Journal of Physics (2014), 16(10), 103003

Sudden avalanches of magnetic flux bursting into a superconducting sample undergo deflections of their trajectories when encountering a conductive layer deposited on top of the superconductor. Remarkably ... [more ▼]

Sudden avalanches of magnetic flux bursting into a superconducting sample undergo deflections of their trajectories when encountering a conductive layer deposited on top of the superconductor. Remarkably, in some cases the flux is totally excluded from the area covered by the conductive layer. We present a simple classical model that accounts for this behaviour and considers a magnetic monopole approaching a semi-infinite conductive plane. This model suggests that magnetic braking is an important mechanism responsible for avalanche deflection. [less ▲]

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See detailThe Gaia-ESO Survey: The analysis of high-resolution UVES spectra of FGK-type stars
Smiljanic, R.; Korn, A. J.; Bergemann, M. et al

in Astronomy and Astrophysics (2014), 570

Context. The ongoing Gaia-ESO Public Spectroscopic Survey is using FLAMES at the VLT to obtain high-quality medium-resolution Giraffe spectra for about 10[SUP]5[/SUP] stars and high-resolution UVES ... [more ▼]

Context. The ongoing Gaia-ESO Public Spectroscopic Survey is using FLAMES at the VLT to obtain high-quality medium-resolution Giraffe spectra for about 10[SUP]5[/SUP] stars and high-resolution UVES spectra for about 5000 stars. With UVES, the Survey has already observed 1447 FGK-type stars. <BR /> Aims: These UVES spectra are analyzed in parallel by several state-of-the-art methodologies. Our aim is to present how these analyses were implemented, to discuss their results, and to describe how a final recommended parameter scale is defined. We also discuss the precision (method-to-method dispersion) and accuracy (biases with respect to the reference values) of the final parameters. These results are part of the Gaia-ESO second internal release and will be part of its first public release of advanced data products. Methods: The final parameter scale is tied to the scale defined by the Gaia benchmark stars, a set of stars with fundamental atmospheric parameters. In addition, a set of open and globular clusters is used to evaluate the physical soundness of the results. Each of the implemented methodologies is judged against the benchmark stars to define weights in three different regions of the parameter space. The final recommended results are the weighted medians of those from the individual methods. Results: The recommended results successfully reproduce the atmospheric parameters of the benchmark stars and the expected T[SUB]eff[/SUB]-log g relation of the calibrating clusters. Atmospheric parameters and abundances have been determined for 1301 FGK-type stars observed with UVES. The median of the method-to-method dispersion of the atmospheric parameters is 55 K for T[SUB]eff[/SUB], 0.13 dex for log g and 0.07 dex for [Fe/H]. Systematic biases are estimated to be between 50-100 K for T[SUB]eff[/SUB], 0.10-0.25 dex for log g and 0.05-0.10 dex for [Fe/H]. Abundances for 24 elements were derived: C, N, O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Mo, Ba, Nd, and Eu. The typical method-to-method dispersion of the abundances varies between 0.10 and 0.20 dex. Conclusions: The Gaia-ESO sample of high-resolution spectra of FGK-type stars will be among the largest of its kind analyzed in a homogeneous way. The extensive list of elemental abundances derived in these stars will enable significant advances in the areas of stellar evolution and Milky Way formation and evolution. Based on observations made with the ESO/VLT, at Paranal Observatory, under program 188.B-3002 (The Gaia-ESO Public Spectroscopic Survey, PIs Gilmore and Randich). Appendices are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201423937/olm">http://www.aanda.org</A> [less ▲]

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See detailTIGRE: A new robotic spectroscopy telescope at Guanajuato, Mexico
Schmitt, J. H. M. M.; Schröder, K.-P.; Rauw, Grégor ULg et al

in Astronomische Nachrichten (2014), 335

TIGRE is a new robotic spectroscopy telescope located in central Mexico at the La Luz Observatory of the University of Guanajuato. The 1.2 m telescope is fiber-coupled to an échelle spectrograph with a ... [more ▼]

TIGRE is a new robotic spectroscopy telescope located in central Mexico at the La Luz Observatory of the University of Guanajuato. The 1.2 m telescope is fiber-coupled to an échelle spectrograph with a spectral resolving power exceeding 20 000 over most of the covered spectral range between 3800 Å and 8800 Å, with a small gap of 130 Å around 5800 Å. TIGRE operates robotically, i.e. it (normally) carries out all observations without any human intervention, including, in particular, the target selection in any given observing night. In this paper we describe the properties of the TIGRE instrumentation and its technical realization, as well as our first operational experience with the performance and efficiency of the overall system. Finally, we present some examples of recent TIGRE observations. [less ▲]

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See detailMulticenter implementation of geriatric assessment in Belgian patients with cancer: A survey on treating physicians' general experiences and expectations.
Kenis, Cindy; Heeren, Pieter; Bron, Dominique et al

in Journal of geriatric oncology (2014), 5(4), 431-438

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A ... [more ▼]

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A survey was carried out in 9 Belgian hospitals, which participated in a national GA implementation project focusing on older patients with cancer. A newly developed questionnaire was completed by their treating physicians. Data collection comprised of reviewing hospital data, general respondent data, and treating physicians' general experiences and expectations regarding GA. Descriptive statistics were calculated. RESULTS: Eighty-two physicians from 9 hospitals participated. The GA team composition can vary substantially, with a nurse as core member. Ideally, all older patients with cancer in whom a treatment decision is necessary, should benefit from the GA. Nearly all GA domains are reported as very important. Availability of GA results can be improved. Treating physicians want geriatricians to coordinate geriatric recommendations related to the identified GA problems, and expect from trained healthcare workers (THCWs) to collect GA data, to report GA results, and to follow-up the implementation of geriatric recommendations. CONCLUSION: This study identifies relevant information for improving the implementation of GA in older patients with cancer in Belgium and reveals priorities for a THCW from the treating physician's point of view. To increase the effectiveness of GA, further efforts are needed to improve the implementation of geriatric recommendations. [less ▲]

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See detailMicrocrystalline cellulose, a direct compression binder in a quality by design environment—A review
Thoorens, Grégory; Krier, Fabrice ULg; Leclercq, Bruno et al

in International Journal of Pharmaceutics (2014), 473(1-2), 64-72

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See detailQTL analysis and candidate gene mapping for the polyphenol content in cider apple
Verdu, Cindy ULg; Guyot, Sylvain; Childebrand, Nicolas et al

in PLoS ONE (2014), 9(10), 107103

Polyphenols have favorable antioxidant potential on human health suggesting that their high content is responsible for the beneficial effects of apple consumption. They control the quality of ciders as ... [more ▼]

Polyphenols have favorable antioxidant potential on human health suggesting that their high content is responsible for the beneficial effects of apple consumption. They control the quality of ciders as they predominantly account for astringency, bitterness, color and aroma. In this study, we identified QTLs controlling phenolic compound concentrations and the average polymerization degree of flavanols in a cider apple progeny. Thirty two compounds belonging to five groups of phenolic compounds were identified and quantified by reversed phase liquid chromatography on both fruit extract and juice, over three years. The average polymerization degree of flavanols was estimated in fruit by phloroglucinolysis coupled to HPLC. Parental maps were built using SSR and SNP markers and used for the QTL analysis. Sixty-nine and 72 QTLs were detected on 14 and 11 linkage groups of the female and male maps, respectively. A majority of the QTLs identified in this study are specific to this population, while others are consistent with previous studies. This study presents for the first time in apple, QTLs for the mean polymerization degree of procyanidins, for which the mechanisms involved remains unknown to this day. Identification of candidate genes underlying major QTLs was then performed in silico and permitted the identification of 18 enzymes of the polyphenol pathway and six transcription factors involved in the apple anthocyanin regulation. New markers were designed from sequences of the most interesting candidate genes in order to confirm their co-localization with underlying QTLs by genetic mapping. Finally, the potential use of these QTLs in breeding programs is discussed. [less ▲]

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See detailSimulation and optimization of a CHP biomass plant and district heating network
Sartor, Kevin ULg; Quoilin, Sylvain ULg; Dewallef, Pierre ULg

in Applied Energy (2014), 130

Biomass Combined Heat and Power (CHP) plants connected to district heating (DH) networks are recognized nowadays as a very good opportunity to increase the share of renewable sources into energy systems ... [more ▼]

Biomass Combined Heat and Power (CHP) plants connected to district heating (DH) networks are recognized nowadays as a very good opportunity to increase the share of renewable sources into energy systems. However, as CHP plants are not optimized for electricity production, their operation is profitable only if a sufficient heat demand is available throughout the year. Most of the time, pre-feasibility studies are based on peak power demand and business plans only assume monthly or yearly consumption data. This approach usually turns out to overestimate the number of operating hours or oversize the plant capacity. This contribution presents a methodology intended to be simple and effective that provides accurate estimations of economical, environmental and energetic performances of CHP plants connected to district heating networks. A quasi-steady state simulation model of a CHP plant combined with a simulation model of the district heating network installed on the Campus of the University in Liège (Belgium) is used as an application framework to demonstrate the effectiveness of the selected approach. Based on the developed model and actual consumption data, several scenarios for energy savings are considered and ranked. The potential energy savings and resulting energy costs are estimated enabling more general conclusions to be drawn on the opportunity of using district heating networks in urban districts for Western Europe countries. [less ▲]

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See detailThe 2.35 year itch of Cygnus OB2 #9. III. X-ray and radio emission analysis based on 3D hydrodynamical modelling
Parkin, E. R.; Pittard, J. M.; Nazé, Yaël ULg et al

in Astronomy and Astrophysics (2014), 570

Context. The wind-wind collision in a massive star binary system leads to the generation of high temperature shocks that emit at X-ray wavelengths and, if particle acceleration is effective, may exhibit ... [more ▼]

Context. The wind-wind collision in a massive star binary system leads to the generation of high temperature shocks that emit at X-ray wavelengths and, if particle acceleration is effective, may exhibit non-thermal radio emission. Cyg OB2#9 is one of a small number of massive star binary systems in this class. <BR /> Aims: X-ray and radio data recently acquired as part of a project to study Cyg OB2#9 are used to constrain physical models of the binary system, providing in-depth knowledge about the wind-wind collision and the thermal, and non-thermal, emission arising from the shocks. <BR /> Methods: We use a 3D, adaptive mesh refinement simulation (including wind acceleration, radiative cooling, and the orbital motion of the stars) to model the gas dynamics of the wind-wind collision. The simulation output is used as the basis for radiative transfer calculations considering the thermal X-ray emission and the thermal/non-thermal radio emission. <BR /> Results: The flow dynamics in the simulation show that wind acceleration (between the stars) is inhibited at all orbital phases by the opposing star's radiation field, reducing pre-shock velocities below terminal velocities. To obtain good agreement with the X-ray observations, our initial mass-loss rate estimates require a down-shift by a factor of ˜7.7 to 6.5 × 10[SUP]-7[/SUP] M[SUB]⊙[/SUB] yr[SUP]-1[/SUP] and 7.5 × 10[SUP]-7[/SUP] M[SUB]⊙[/SUB] yr[SUP]-1[/SUP] for the primary and secondary star, respectively. Furthermore, the low gas densities and high shock velocities in Cyg OB2 #9 are suggestive of unequal electron and ion temperatures, and the X-ray analysis indicates that an immediately post-shock electron-ion temperature ratio of ≃0.1 is also required. The radio emission is dominated by non-thermal synchrotron emission. A parameter space exploration provides evidence against models assuming equipartition between magnetic and relativistic energy densities. However, fits of comparable quality can be attained with models having stark contrasts in the ratio of magnetic-to-relativistic energy densities. Both X-ray and radio lightcurves are largely insensitive to viewing angle. The variations in X-ray emission with orbital phase can be traced back to an inverse relation with binary separation and pre-shock velocity. The radio emission also scales with pre-shock velocity and binary separation, but to positive powers (i.e. not inversely). The radio models also reveal a subtle effect whereby inverse Compton cooling leads to an increase in emissivity as a result of the synchrotron characteristic frequency being significantly reduced. Finally, using the results of the radio analysis, we estimate the surface magnetic field strengths to be ≈0.3 - 52G. [less ▲]

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See detailMagnetization of 2-G Coils and Artificial Bulks
Coombs, Tim; Fagnard, Jean-François ULg; Matsuda, Koichi

in IEEE Transactions on Applied Superconductivity (2014), 24(5), 8201005

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See detailLa ludicisation des pratiques d’écriture sur Internet : une étude des fanfictions comme dispositifs jouables
Barnabé, Fanny ULg

in Sciences du jeu (2014), 2(Automne),

This paper aims for studying the ludification phenomenon through one of its realizations: the introduction of play in the writing of fan fictions on the Internet. According to the perspective of the "play ... [more ▼]

This paper aims for studying the ludification phenomenon through one of its realizations: the introduction of play in the writing of fan fictions on the Internet. According to the perspective of the "play studies" (Triclot, 2011) and of the "play design" (Genvo, 2008), the ludification is defined here as the generalization of a "playful attitude" observable through the traces (the "signs of playability") it leaves on the objects it appropriates. This work therefore seeks to identify, within a corpus of fan fiction inspired by the videogame series Kingdom Hearts, any marks of the playful use that is made of these texts. The modifications occasioned, in the practice, by the use of digital technology will also be considered (can this "ludogenic" media increase the playability?; Vial, 2012). The fan fiction will successively be considered as a community phenomenon, as a writing practice and, finally, as a set of texts. [less ▲]

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See detailRetrospective analysis of a suburban out-ofhours clinic in Belgium
Belche, Jean-Luc ULg; Berrewaerts, Marie-Astrid ULg; Burette, Philippe ULg et al

in Acta Clinica Belgica (2014), 69(5), 341-347

Introduction: In many countries, out-of-hours medical care is under scrutiny. The aim of this article is to study the activities recorded by the first out-of-hours clinic that has been opened, as a pilot ... [more ▼]

Introduction: In many countries, out-of-hours medical care is under scrutiny. The aim of this article is to study the activities recorded by the first out-of-hours clinic that has been opened, as a pilot study, in two Walloon communes. Material and method: A retrospective analysis of anonymized data was conducted for 2009. Coding of diagnoses was conducted using the International Classification of Primary Care (ICPC-2). Results: A total of 3949 contacts were recorded in 2009 with the out-of-hours clinic, 3294 related to inhabitants of the two communes covered, which was equivalent to 13% of the total population in question. Compared to 7.2% of contacts between midnight and 8 a.m., 82.9% of contacts took place between 8 a.m. and 9 p.m., and 91.6% of contacts were handled locally, with only 8.4% resulting in hospitalization. In addition, 52% of contacts were with patients aged between 25 and 65; 29.9% of contacts were with paediatric patients (,15 years). Patients over the age of 65 made up 18% of contacts. The most common pathologies were respiratory (R). Analysis of flu diagnoses identified two epidemic peaks. Discussion: The suburban out-of-hours clinic studied fulfilled an important role in managing the demand for health care. The large majority of health problems were resolved locally, and the inhabitants did not need to go to hospital. Appointments between midnight and 8 a.m. were in the minority, which points towards adjusting the organization of the out-of-hours service during the night. The geriatric population is not highly over-represented contrary to what might be expected considering its largest number of pathologies. The on-call doctor’s skills profile should take account of the populations and morbidities encountered. Out-ofhours clinics could possibly play a sentinel role in terms of flu epidemics. Conclusion: This study describes a pilot suburban out-of-hours clinic which met three of recommendations set by the KCE in its report on out-of-hours care in general medicine: the organization of an out-of-hours clinic with logistical support, the use of a single telephone number and merging out-of-hours areas. While debate exists on the management of out-of-hours care, this study provides evidence on the role of the physician during these hours. [less ▲]

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See detailData processing of vibrational chemical imaging for pharmaceutical applications.
Sacre, Pierre-Yves ULg; De Bleye, Charlotte ULg; Chavez, Pierre-François ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2014), 101

Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational ... [more ▼]

Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational spectroscopy to imaging techniques and allows therefore the visualization of distribution of compounds, crystallization processes. However, these techniques provide a huge amount of data that must be processed to extract the relevant information. This review presents fundamental concepts of hyperspectral imaging, the basic theory of the most used chemometric tools used to pre-process, process and post-process the generated data. The last part of the present paper focuses on pharmaceutical applications of hyperspectral imaging and highlights the data processing approaches to enable the reader making the best choice among the different tools available. [less ▲]

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See detailL’ANATOMIE REVISITÉE DU PETIT BASSIN
Bonnet, Pierre ULg

in Louvain Medical (2014), 133(8), 3-13

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des ... [more ▼]

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des parois latérales au sein de l’espace endopelvien, leur innervation dépend d’une double origine, abdominale et pelvienne. Les parois de cet espace abritent les nerfs somatiques et vaisseaux destinés aux parois de la partie inférieure du tronc et aux membres inférieurs. La connaissance pratique de cette anatomie peut être aidée par une approche constructive élaborant les parois et ensuite le contenu de cet espace. [less ▲]

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