References of "Article"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 501 to 600 of 56534     1 2 3 4 5 6 7 8 9 10 11     EditorialDewals, Benjamin in Proceedings of ICE : Water Management (2017), 170(WM3), 109-110Detailed reference viewed: 9 (1 ULiège) Trop beau pour être vrai ? Quand un effet largement positif n’est pas nécessairement conclusifHenrard, Gilles in Minerva: Tijdschrift Voor Evidence Based Medicine (2017)Detailed reference viewed: 14 (0 ULiège) Solidarité intergénérationnelle chez les migrantes sud-américainesVivas Romero, Maria ; Piddiu, Lucain Voix Solidaires (2017), 22(été 2017), 14-16Detailed reference viewed: 15 (0 ULiège) Surface Modification of Powder Metallurgy Titanium by Colloidal Techniques and Diffusion Processes for Biomedical ApplicationsUreña, Julia; Mendoza Gallego, Carlos ; Ferrari, Begoña et alin Advanced Engineering Materials (2017), 19(6), This contribution focuses on modifying the composition and surface characteristics of powder metallurgy titanium substrates to improve their wear resistance and to reduce the surface Younǵs modulus, while ... [more ▼]This contribution focuses on modifying the composition and surface characteristics of powder metallurgy titanium substrates to improve their wear resistance and to reduce the surface Younǵs modulus, while maintaining the corrosion resistance and biocompatibility. The modification consists of Mo and TiN coatings produced by colloidal techniques which are deposited by electrophoretic deposition (EPD) or spraying onto green or sintered titanium substrates. The final surface structures are formed during a heat treatment, during which diffusion and consolidation of the layers take place. The surfaces are characterised by XRD, SEM, and micro-indentation; showing diffusion areas of between 40 and 85 microns with clear microstructural changes as well as higher hardness values. [less ▲]Detailed reference viewed: 31 (12 ULiège) Le cas clinique du mois. Embolie pulmonaire compliquée d’un œdème laryngé angioneurotique.LOPEZ IGLESIAS, Raphaelle ; CUPPENS, Benoit ; ROBINET, Sébastien et alin Revue Médicale de Liège (2017), 72(6), 275-280Detailed reference viewed: 43 (2 ULiège) Evolution and diversity of ram-suction feeding in damselfishes (Pomacentridae)Olivier, Damien ; Gajdzik, Laura ; Parmentier, Eric et alin Organisms Diversity & Evolution (2017), 17The cerato-mandibular (c-md) ligament is a synapomorphy within Pomacentridae that creates a tight link between the lower jaws and the hyoid bars. However, this morphological trait has been secondarily ... [more ▼]The cerato-mandibular (c-md) ligament is a synapomorphy within Pomacentridae that creates a tight link between the lower jaws and the hyoid bars. However, this morphological trait has been secondarily lost in multiple lineages during evolution. A previous study revealed that the loss of this trait acted as a release of evolutionary constraints, leading to a cascade of morphological changes such elongated buccal jaws and a slender body. Ecomorphological interpretations suggested the loss of the c-md ligament has ultimately led to a new adaptive peak in zooplanktivory through an optimization of the ram feeding mode associated with a specialization in pelagic feeding. Here, we tested these hypotheses by comparing functional and diet diversity between damselfish species with and without the c-md ligament. Although species lacking the c-md ligament presented a conserved kinematic pattern resulting from high ram and low suction performances, our results did not support an optimization of the ram feeding mode. Indeed, some species with the c-md ligament showed the same or exceeded the ram performance of species without the c-md ligament. The species with the c-md ligament had a more diverse kinematic pattern exploring the entire ram-suction functional range in damselfishes. Finally, our results did not show any diet variations associated with the loss of the c-md ligament. Our study furthers the understanding of how a morphological trait has shaped, by its presence or absence, the ecomorpho-functional diversification of Pomacentridae. [less ▲]Detailed reference viewed: 35 (10 ULiège) Electro dynamic fragmentation of printed wiring boards as a preparation tool for their recyclingMartino, Rémi; Iseli, Cedric; Gaydardzhiev, Stoyan et alin Minerals Engineering (2017), 107The use of Electro Dynamic Fragmentation (EDF) enables selective fragmentation of materials through generating electrical discharges as a means of fracturing. Liberated materials can be thus processed ... [more ▼]The use of Electro Dynamic Fragmentation (EDF) enables selective fragmentation of materials through generating electrical discharges as a means of fracturing. Liberated materials can be thus processed downstream in a more efficient way especially when value-added End-of-Life (EoL) electronic equipment is recycled. The aim of this study was to assess the benefits of the EDF technology towards processing of EoL printed wiring boards (PWBs) in view their recyclability. Printed wiring boards were comminuted using EDF at three different settings and with a hammer mill for comparative experiment. The products coming out were characterized by optical microscopy, SEM and liberation oriented leaching. Subsamples from the various EDF stages were inspected to investigate the progress of cracks and degree of copper layers exposure. The different energy levels used during the EDF processing have resulted in different degrees of PWBs damages, starting from components removal to entire structure perturbation and size reduction. EDF has resulted in generation of a lesser amount of fines, however the optimal approach in view energy efficient post-processing of the studied PWBs was the combination between single-stage EDF for components removal only with subsequent shredding of the depopulated boards. [less ▲]Detailed reference viewed: 63 (15 ULiège) Localizing value of electrical source imaging: Frontal lobe, malformations of cortical development and negative MRI related epilepsies are the best candidatesAbdallah, Chifaou; Maillard, Louis George; RIKIR, Estelle et alin NeuroImage: Clinical (2017), 16Detailed reference viewed: 11 (0 ULiège) Insect fatty acids: A comparison of lipids from three Orthopterans and Tenebrio molitor L. larvaePaul, Aman ; Frederich, Michel ; Caparros Megido, Rudy et alin Journal of Asia-Pacific Entomology (2017), 20(2), 337-340In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and ... [more ▼]In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and compared with those of Tenebrio molitor larvae. A. domesticus, Co. discolor, Ch. parallelus and T. molitor larvae were found to contain approximately 15%, 13%, 10% and 32% lipids on dry weight, respectively. The lipids from three Orthopterans contain much higher amounts of essential fatty acids than those of T. molitor larvae. The two Orthopterans of the suborder Ensifera i.e., A. domesticus and Co. discolor contain linoleic acid in major quantities, while Ch. parallelus of the suborder Caelifera, contain α-linolenic acid in major quantities. The consumption of linoleic and α-linolenic fatty acid is linked with numerous health promoting effects. The factors that contribute to differences in fatty acid profiles of these insects are being discussed. At last the nutritional parameters including polyunsaturated to saturated and omega 6 to omega 3 fatty acid ratios of these insect lipids are also being discussed to understand the potential role of these lipids in human nutrition. [less ▲]Detailed reference viewed: 138 (30 ULiège) Mapping Soil Organic Carbon stocks and estimating uncertainties at the regional scale following a legacy sampling strategy (Southern Belgium, Wallonia)Chartin, Caroline; Stevens, Antoine; Goidts, Esther et alin Geoderma Regional (2017), 9The quantification and the spatialisation of reliable SOC stocks (Mg C ha− 1) and total stock (Tg C) baselines and associated uncertainties are fundamental to detect the gains or losses in SOC, and to ... [more ▼]The quantification and the spatialisation of reliable SOC stocks (Mg C ha− 1) and total stock (Tg C) baselines and associated uncertainties are fundamental to detect the gains or losses in SOC, and to locate sensitive areas with low SOC levels. Here, we aim to both quantify and spatialize SOC stocks at regional scale (southern Belgium) based on data from one non-design-based or model-based sampling scheme. To this end, we developed a computation procedure based on Digital Soil Mapping techniques and stochastic simulations (Monte-Carlo) allowing the estimation of multiple (here, 10,000) independent spatialized datasets. The computation of the prediction uncertainty accounts for the errors associated to both the estimations of i) SOC stocks and ii) parameters of the spatial model. Based on these 10,000 individuals, median SOC stocks and 90% prediction intervals were computed for each pixel, as well as total SOC stocks and their 90% prediction intervals for selected sub-areas and for the entire study area. Hence, a Generalised Additive Model (GAM) explaining 69.3% of the SOC stock variance was calibrated and then validated (R2 = 0.64). The model overestimated low SOC stock (below 50 Mg C ha− 1) and underestimated high SOC stock (especially those above 100 Mg C kg− 1). A positive gradient of SOC stock occurred from the northwest to the center of Wallonia with a slight decrease on the southernmost part, correlating to the evolution of precipitation and temperature (along with elevation) and dominant land use. At the catchment scale higher SOC stocks were predicted on valley bottoms, especially for poorly drained soils under grassland. Mean predicted SOC stocks for cropland and grassland in Wallonia were of 26.58 Tg C (SD 1.52) and 43.30 Tg C (2.93), respectively. The procedure developed here allowed to predict realistic spatial patterns of SOC stocks all over agricultural lands of southern Belgium and to produce reliable statistics of total SOC stocks for each of the 20 combinations of land use/agricultural regions of Wallonia. This procedure appears useful to produce soil maps as policy tools in conducting sustainable management at regional and national scales, and to compute statistics which comply with specific requirements of reporting activities. [less ▲]Detailed reference viewed: 43 (8 ULiège) Epidemiology of chronic kidney disease: think (at least) twice!DELANAYE, Pierre ; Glassock, RJ; De Broe, MEin Clinical Kidney Journal (2017), 10(3), 370-374Detailed reference viewed: 29 (0 ULiège) Period–luminosity relations of fast-rotating B-type stars in the young open cluster NGC 3766Saio, H.; Ekström, S.; Mowlavi, N. et alin Monthly Notices of the Royal Astronomical Society (2017), 467(4), 3864-3873We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We ... [more ▼]We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We compare the properties of prograde sectoral g and retrograde r modes excited by the κ mechanism at the Fe opacity peak with the newly discovered period–luminosity relation that is obeyed by a group of fast-rotating B-type stars in the young open cluster NGC 3766. The observed relation consists of two sequences in the period versus magnitude diagram, at periods shorter than 0.5 d. We find that this property is consistent with similar period–luminosity relations predicted for excited sectoral prograde g modes of azimuthal orders m = −1 and −2 in fast-rotating stars along an isochrone. We further show that some of the rapidly rotating stars that have photometric variability with periods longer than a day may be caused by r-mode pulsation predicted to be excited in these stars. One fast-rotating star, in particular, shows both short and long periods that can be explained by the simultaneous excitation of g- and r-mode pulsations in models of fast-rotating stars. [less ▲]Detailed reference viewed: 15 (3 ULiège) Why Collaborative Care for Depressed Patients is so Difficult: A Belgian Qualitative StudyVan den Broeck, Kris; Ketterer, Frédéric ; Remmen, Roy et alin International Journal of Integrated Care [=IJIC] (2017), 17(2), 1-9Although current guidelines recommend collaborative care for severely depressed patients, few patients get adequate treatment. In this study we aimed to identify the thresholds for interdisciplinary ... [more ▼]Although current guidelines recommend collaborative care for severely depressed patients, few patients get adequate treatment. In this study we aimed to identify the thresholds for interdisciplinary collaboration amongst practitioners when treating severely depressed patients. In addition, we aimed to identify specific and feasible steps that may add to improved collaboration amongst first and second level Belgian health care providers when treating depressed patients. In two standard focus groups (n = 8; n = 12), general practitioners and psychiatrists first outlined current practice and its shortcomings. In a next phase, the same participants were gathered in nominal groups to identify and prioritise steps that could give rise to improved collaboration. Thematic analyses were performed. Though some barriers for interdisciplinary collaboration may seem easy to overcome, participants stressed the importance of certain boundary conditions on a macro- (e.g., financing of care, secure communication technology) and meso-level (e.g., support for first level practitioner). Findings are discussed against the background of frameworks on collaboration in healthcare and recent developments in mental health care. [less ▲]Detailed reference viewed: 24 (3 ULiège) LE CONTRÔLE DES NORMES RELATIVES À LA MODÉRATION DES RÉMUNÉRATIONS AU REGARD DU DROIT DE NÉGOCIATION COLLECTIVEClesse, Jacques ; Kéfer, Fabienne in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2017), (1-2), 89-112En moins d’une semaine, deux lois ayant un impact important sur le montant des salaires sont entrées en vigueur. La loi du 23 avril 2015 concernant la promotion de l’emploi impose un saut d’index. La loi ... [more ▼]En moins d’une semaine, deux lois ayant un impact important sur le montant des salaires sont entrées en vigueur. La loi du 23 avril 2015 concernant la promotion de l’emploi impose un saut d’index. La loi du 28 avril 2015 établit la marge maximale pour l’évolution du coût salarial pour les années 2015 et 2016. Ces deux lois ont provoqué une forte opposition de la part des organisations syndicales. Traditionnellement, en Belgique, la formation des salaires relève de l’autonomie des partenaires sociaux. Par la voie des conventions collectives de travail, ceux-ci établissent le montant minimum des rémunérations au niveau du pays et des secteurs d’activité. Les organisations syndicales ont vu dans ces deux lois une atteinte grave portée par l’État à la concertation sociale. Après une première partie décrivant, sans pouvoir être exhaustive, les mécanismes de modération des salaires utilisés en Belgique depuis 1976, la contribution a pour objet d’examiner la régularité juridique de ces deux lois en regard du droit de négociation collective. Ce droit, qui constitue l’un des fondements juridiques du dialogue social et de l’action syndicale, appartient au catalogue des droits fondamentaux puisqu’il a été reconnu par différents instruments internationaux ainsi que par la Constitution de la Belgique. [less ▲]Detailed reference viewed: 56 (5 ULiège) CKD-EPI equation: a suitable glomerular filtration rate estimate for drug dosing in HIV-infected patientsGagneux-Brunon, A; Bothelo-Nevers, E; DELANAYE, Pierre et alin Médecine et Maladies Infectieuses (2017), 47(4), 266-270Detailed reference viewed: 19 (0 ULiège) Sniffing out the hypoxia volatile metabolic signature of Aspergillus fumigatusRees, Christiaan A; Stefanuto, Pierre-Hugues ; Beattie, Sarah R et alin Journal of Breath Research (2017), 036003Invasive aspergillosis (IA) is a life-threatening infectious disease caused by fungi from the genus Aspergillus, with an associated mortality as high as 90% in certain populations. IA-associated pulmonary ... [more ▼]Invasive aspergillosis (IA) is a life-threatening infectious disease caused by fungi from the genus Aspergillus, with an associated mortality as high as 90% in certain populations. IA-associated pulmonary lesions are characteristically depleted in oxygen relative to normal lung tissue, and it has been shown that the most common causal agent of IA, Aspergillus fumigatus, must respond to lowoxygen environments for pathogenesis and disease progression. Previous studies have demonstrated marked alterations to the Aspergillus fumigatus transcriptome in response to low-oxygen environments that induce a ‘hypoxia response’. Consequently, we hypothesized that these transcriptomic changes would alter the volatile metabolome and generate a volatile hypoxia signature. In the present study, we analyzed the volatile molecules produced by A. fumigatus in both oxygen replete (normoxia) and depleted (hypoxia) environments via headspace solid-phase micro-extraction coupled to twodimensional gas chromatography-time-of-flight mass spectrometry. Using the machine learning algorithm random forest, we identified 19 volatile molecules that were discriminatory between the four growth conditions assessed in this study (i.e., early hypoxia (1 h), late hypoxia (8 h), early normoxia (1 h), and late normoxia (8 h)), as well as a set of 19 that were discriminatory between late hypoxia cultures and all other growth conditions in aggregate. Nine molecules were common to both comparisons, while the remaining 20 were specific to only one of two.Weassigned putative identifications to 13 molecules, of which six were most highly abundant in late hypoxia cultures. Previously acquired transcriptomic data identified putative biochemical pathways induced in hypoxia conditions that plausibly account for the production of a subset of these molecules, including 2,3-butanedione and 3-hydroxy-2-butanone. These two molecules may represent a novel hypoxia fitness pathway in A. fumigatus, and could be useful in the detection of hypoxia-associated A. fumigatus lesions that develop in established IA infections. [less ▲]Detailed reference viewed: 66 (4 ULiège) Luciobarbus chelifensis and L. mascarensis, two new species from Algeria (Teleostei: Cyprinidae)Brahimi, Amina; Freyhof, Jörg; Henrard, Arnaud et alin Zootaxa (2017), 4277(1), 32-50Cyprinids of the genus Luciobarbus are the most abundant and widespread fishes in most freshwater ecosystems in the Maghreb. In the Mediterranean basin of Morocco, Algeria and Tunisia, all species of ... [more ▼]Cyprinids of the genus Luciobarbus are the most abundant and widespread fishes in most freshwater ecosystems in the Maghreb. In the Mediterranean basin of Morocco, Algeria and Tunisia, all species of Luciobarbus—with exception of L. guercifensis—are superficially very similar and are distinguished mostly by minor morphometric characters. Molecular characters distinguish all species well and nine species are recognised from the area, two of them described here. Luciobarbus chelifensis, from the Chelif River drainage in Algeria, is distinguished by having 41–43+1–2 lateral line scales and a very short anal fin (18–19% SL). Luciobarbus mascarensis, from the Macta River drainage in Algeria, is distinguished by having usually 41+1–2 lateral line scales, a long anal-fin (19–22%) and a short caudal peduncle (15–17% SL). An identification key is given for all African Mediterranean Luciobarbus species except for L. callensis and L. rifensis, which could not be distinguished. [less ▲]Detailed reference viewed: 32 (2 ULiège) Gastrointestinal Parasites in Captive and Free-ranging Cebus albifrons in the Western Amazon, Ecuador.Martin, Sarah ; Carrillo Bilbao, Gabriel Alberto; Ramirez, William et alin International Journal for Parasitology: Parasites and Wildlife (2017)Currently, there is a lack of surveys that report the occurrence of gastrointestinal parasites in the white-headed capuchin monkey (Cebus albifrons). We therefore assessed the presence and richness ... [more ▼]Currently, there is a lack of surveys that report the occurrence of gastrointestinal parasites in the white-headed capuchin monkey (Cebus albifrons). We therefore assessed the presence and richness (= number of different parasite genera) of parasites in C. albifrons in wildlife refuges (n = 11) and in a free-ranging group near a human village (n = 15) in the Ecuadorian Amazon. In the 78 samples collected (median of 3 samples per animal), we identified a total of 6 genera of gastrointestinal parasites, representing protozoa, nematodes, acantocephalan and cestodes. We observed a high prevalence (84%) across the 26 individuals, with the most prevalent parasite being Strongyloides sp. (76.9%), followed by Hymenolepis sp. (38.5%) and Prosthenorchis elegans (11.5%). We found Entamoeba histolytica/dispar/moskovskii/nuttalli and Capillaria sp. in only a minority of the animals (3.8%). In addition, we observed unidentified strongyles in approximately one-third of the animals (34.6%). We found a total of 6 parasite genera for the adult age group, which showed higher parasite richness than the subadult age group (5) and the juvenile age group (3). Faecal egg/cyst counts were not significantly different between captive and free-ranging individuals or between sexes or age groups. The free-ranging group had a higher prevalence than the captive group; however, this difference was not significant. The only genus common to captive and free-ranging individuals was Strongyloides sp. The high prevalence of gastrointestinal parasites and the presence of Strongyloides in both populations support results from previous studies in Cebus species. This high prevalence could be related to the high degree of humidity in the region. For the free-ranging group, additional studies are required to gain insights into the differences in parasite prevalence and intensity between age and sex groups. Additionally, our study demonstrated that a serial sampling of each individual increases the test sensitivity. [less ▲]Detailed reference viewed: 20 (5 ULiège) The diagnostic value of rescaled renal biomarker serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate.Pottel, H; Dubourg, L; Schaeffner, E et alin Clinica Chimica Acta (2017), 471Detailed reference viewed: 29 (1 ULiège) Le lock-out de Verviers en 1906 vu par Léon de SeilhacGeerkens, Eric in Cahiers Jaurès (2017), 223-224Detailed reference viewed: 30 (1 ULiège) Traitement au désoxycorticostérone pivalate et à la prednisolone chez un chat souffrant d'hypoadrénocorticismeSchils, Gaëlle ; Darnis, Elodie ; Gommeren, Kris in Le Monde Vétérinaire (2017)Detailed reference viewed: 18 (1 ULiège) Magnetic Shielding Above 1 T at 20 K With Bulk, Large Grain YBCO Tubes Made by Buffer-aided Top Seeded Melt GrowthWera, Laurent ; Fagnard, Jean-François ; Kumar, Numbury Devendra et alin IEEE Transactions on Applied Superconductivity (2017), 27(4), YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and ... [more ▼]YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and are observed to reduce axial flux densities of 1.5 T by a factor of 100 at 20 K. Such performances are comparable in magnitude to the record threshold inductions reported for bulk MgB2 and Bi-2212 materials at lower temperatures. Magnetic shielding measurements for open and closed tubes at 77 K also show that the presence of the cap improves substantially the shielding performance at the closed extremity since it reduces the penetration through the open end. This fabrication technique is extremely promising for shielding “dc” stray fields generated by HTS magnets operated in a temperature range obtained by cryocoolers, liquid hydrogen (20 K) or liquid neon (27 K). [less ▲]Detailed reference viewed: 62 (20 ULiège) A decision support tool for transient stability preventive controlPertl, Michael; Weckesser, Johannes ; Rezkalla, Michel et alin Electric Power Systems Research (2017), 147The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the ... [more ▼]The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the state of the power system in terms of transient stability. A time-domain approach is used to assess the transient stability for potentially critical faults. Potential critical fault locations are identified by a critical bus screening through analysis of pre-disturbance steady-state conditions. The identified buses are subject to a fast critical contingency screening determining the actual critical contingencies/buses. These two screenings aim at reducing the computational burden of the assessment, since only contingencies considered as critical are taken into account. The critical clearing times for the critical contingencies are determined. A preventive re-dispatch of generators to ensure a predefined minimum critical clearing time for faults at all buses is proposed, while costs are minimized. The results of the assessment are presented to the control room operator, who decides to accept the suggested dispatch or to repeat the assessment considering additional user-specific constraints. The effectiveness of the proposed method is demonstrated on a standard nine-bus and the New England test system. [less ▲]Detailed reference viewed: 37 (9 ULiège) Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate ReceptorsLarsen, Anja Probst; Fièvre, Sabine; Frydenvang, Karla et alin Molecular Pharmacology (2017), 91Kainate receptors (KARs) consist of a class of ionotropic gluta- mate receptors, which exert diverse pre- and postsynaptic functions through complex signaling regulating the activity of neural circuits ... [more ▼]Kainate receptors (KARs) consist of a class of ionotropic gluta- mate receptors, which exert diverse pre- and postsynaptic functions through complex signaling regulating the activity of neural circuits. Whereas numerous small-molecule positive allosteric modulators of the ligand-binding domain of (S)-2- amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid (AMPA) receptors have been reported, no such ligands are avail- able for KARs. In this study, we investigated the ability of three benzothiadiazine-based modulators to potentiate glutamate-evoked currents at recombinantly expressed KARs. 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1- dioxide (BPAM344) potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 mM), with an EC50 of 79 mM. BPAM344 markedly decreased desensitization kinetics (from 5.5 to 775 ms), whereas it only had a minor effect on deactivation kinetics. 4-cyclopropyl-7-hydroxy-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BPAM521) potentiated the recorded peak current amplitude of GluK2a 12-fold at a concen- tration of 300 mM with an EC50 value of 159 mM, whereas no potentiation of the glutamate-evoked response was observed for 7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BPAM121) at the highest concentration of modulator tested (300 mM). BPAM344 (100 mM) also potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15- fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold). X-ray structures of the three modulators in the GluK1 ligand-binding domain were determined, locating two modulator- binding sites at the GluK1 dimer interface. In conclusion, this study may enable the design of new positive allosteric modulators selective for KARs, which will be of great interest for further investigation of the function of KARs in vivo and may prove useful for pharmacologically controlling the activity of neuronal networks. [less ▲]Detailed reference viewed: 18 (3 ULiège) Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney diseaseCiolek, Justyna; Reinfrank, Helen; Quinton, Loïc et alin Proceedings of the National Academy of Sciences of the United States of America (2017)Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin ... [more ▼]Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 155 other G-protein–coupled receptors or on 15 ionic channels. Mambaquaretin-1 is a full antagonist of the V2R activation pathways studied: cAMP production, beta-arrestin interaction, and MAP kinase activity. This peptide adopts the Kunitz fold known to mostly act on potassium channels and serine proteases. Mambaquaretin-1 interacts selectively with the V2R through its first loop, in the same manner that aprotinin inhibits trypsin. Injected in mice, mambaquaretin-1 increases in a dose-dependent manner urine outflow with concomitant reduction of urine osmolality, indicating a purely aquaretic effect associated with the in vivo blockade of V2R. CD1-pcy/pcy mice, a juvenile model of PKD, daily treated with 13 μ𝝁g of mambaquaretin-1 for 99 d, developed less abundant (by 33%) and smaller (by 47%) cysts than control mice. Neither tachyphylaxis nor apparent toxicity has been noted. Mambaquaretin-1 represents a promising therapeutic agent against PKDs. [less ▲]Detailed reference viewed: 44 (5 ULiège) Percepire la sofferenza degli animali. Fondamenti per un’empatia interspecificaServais, Véronique in Animal Studies (2017), 17Detailed reference viewed: 24 (1 ULiège) Sartre, hériter de Heidegger ? Quelques remarques à propos du circuit de l'ipséité dans "L'Être et le Néant" [titre provisoire]Recchia, Fabio in Revista Ética e Filosofia Política (2017), 1Il n’est en philosophie d’héritage que gagné. Et en m’installant dans cette ambigüité propre au savoir philosophique, j’examine, dans ce texte, un développement peu étudié de la pensée sartrienne : sa ... [more ▼]Il n’est en philosophie d’héritage que gagné. Et en m’installant dans cette ambigüité propre au savoir philosophique, j’examine, dans ce texte, un développement peu étudié de la pensée sartrienne : sa théorie du « circuit de l’ipséité » de la conscience. Quant à mon objectif, il s’agira de faire le point sur le processus de maturation intellectuelle à l’issue duquel Sartre conçut l’ipséité comme un circuit. Ainsi je mets en évidence que certaines des réflexions de Heidegger, Bergson et Mauss, sur la notion d’identité personnelle ont constitué les héritages philosophiques mobilisés et transformés par la théorie sartrienne de l’ipséité. [less ▲]Detailed reference viewed: 56 (11 ULiège) The role of market-oriented institutions in the deployment of renewable energies: evidences from EuropeJacqmin, Julien in Applied Economics (2017)Focusing on European countries, this article investigates the link between market-oriented institutions, as measured by the Economic Freedom Index, and the production of energy from renewable sources. A ... [more ▼]Focusing on European countries, this article investigates the link between market-oriented institutions, as measured by the Economic Freedom Index, and the production of energy from renewable sources. A dynamic panel approach shows that this correlation is positive and significant while the subcomponents of the Economic Freedom Index reveal that not all market-oriented institutions have a similar impact. Indeed, long-term price stability and freedom to trade boost the reliance on renewable energies whereas the importance given to markets rather than governments has no significant impact. [less ▲]Detailed reference viewed: 26 (5 ULiège) Pour un droit fondamental au logement : émergence et nuancesQuintart, Aurélie in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2017)The fundamental right to housing is written in article 23 of our Constitution along with others social and economical rights since 1994. It is said to be a necessary component for the right to respect for ... [more ▼]The fundamental right to housing is written in article 23 of our Constitution along with others social and economical rights since 1994. It is said to be a necessary component for the right to respect for human dignity. For the last decades, the right to housing has been quoted in many international declarations and conventions. However we still wonder: what is the real impact of this right to housing? How effective can it be? What interpretation can we give to case-law in this regard? We would like to bring some ideas and answer to the debate. Our article analyses the right to housing nowadays, as emerging out of treaties, laws and the international and national case-law. [less ▲]Detailed reference viewed: 26 (6 ULiège) Knowledge, Attitudes and Awareness of Pre-Service Teachers on Biodiversity Conservation in RwandaNsengimana, Venuste in INTERNATIONAL JOURNAL OF ENVIRONMENTAL & SCIENCE EDUCATION (2017)This research presents a case study on the knowledge of pre-service teachers of the school of lower secondary education on biodiversity conservation in Rwanda. It critically examines the implication of ... [more ▼]This research presents a case study on the knowledge of pre-service teachers of the school of lower secondary education on biodiversity conservation in Rwanda. It critically examines the implication of the level of knowledge on attitudes and behaviors towards biodiversity conservation and the potential implications of a lack of the courses focusing on biodiversity conservation in the school of lower secondary education, and presents empirical data from a survey and group discussions. Results showed that generally the level of knowledge of pre-service teachers on biodiversity conservation is high, and there is positive correlation between knowledge, awareness and attitude, which in turn may contribute to sustainable biodiversity conservation in Rwanda. Research concluded that there should be another research on the side of primary and secondary students in order to verify if the skills of teachers in biodiversity conservation are fully taught to the students. [less ▲]Detailed reference viewed: 15 (0 ULiège) Esfera pública discursiva, nº2Becerra Mayor, David in Esfera pública discursiva (2017), 2Número 2 de "Esfera pública discursiva", revista de crítica e información literaria realizada por los estudiantes de "Stylistique et critique de l'espagnol moderne" de la Université de LiègeDetailed reference viewed: 34 (0 ULiège) Morphology of the UV aurorae Jupiter during Juno’s first perijove observationsBonfond, Bertrand ; Gladstone, G. R.; Grodent, Denis et alin Geophysical Research Letters (2017)On 27 August 2016, the NASA Juno spacecraft performed its first close-up observations of Jupiter during its perijove. Here we present the UV images and color ratio maps from the Juno-ultraviolet ... [more ▼]On 27 August 2016, the NASA Juno spacecraft performed its first close-up observations of Jupiter during its perijove. Here we present the UV images and color ratio maps from the Juno-ultraviolet spectrometer UV imaging spectrograph acquired at that time. Data were acquired during four sequences (three in the north, one in the south) from 5:00 UT to 13:00 UT. From these observations, we produced complete maps of the Jovian aurorae, including the nightside. The sequence shows the development of intense outer emission outside the main oval, first in a localized region (255 ∘ –295 ∘ System III longitude) and then all around the pole, followed by a large nightside protrusion of auroral emissions from the main emission into the polar region. Some localized features show signs of differential drift with energy, typical of plasma injections in the middle magnetosphere. Finally, the color-ratio map in the north shows a well-defined area in the polar region possibly linked to the polar cap. [less ▲]Detailed reference viewed: 53 (17 ULiège) What can agricultural land use planning contribute to food production and food policyBousbaine, Antonia in International Journal of Avian & Wildlife Biology (2017), Vol 2 issue 1Food Security and Food Sovereignty are two of the most important issues facing Food Policy. Maintaining productive farmland and sustainable farms as well as providing adequate volumes of foodstuffs have ... [more ▼]Food Security and Food Sovereignty are two of the most important issues facing Food Policy. Maintaining productive farmland and sustainable farms as well as providing adequate volumes of foodstuffs have led to measures to protect farmland and farm activities in many countries. These include land use planning with agricultural zones and in some jurisdictions legislation to ‘protect’ agriculture in agricultural reserves. Are these tools adequate to maintain sustainable agricultures particularly around major urban and metropolitan centers. Agricultural zones and agricultural reserves in many jurisdictions have continued to experience removal of farmland in order to permit different types of urban development (e.g. residential development and industrial parks). An emerging response to this has been the integration of strategic development planning for agriculture in certain jurisdictions (e.g. the province of Quebec (Canada)), because this approach can integrate the necessary parameters to enable the development of sustainable agricultures, including how to respond to opportunities as well as adapting to emerging stressors. This approach also ideally requires the integration of farmers and their families as actors and participants in the strategic development planning process. [less ▲]Detailed reference viewed: 42 (3 ULiège) Is the arbitrary symmetrical?Badir, Sémir in Semiotica (2017)Arbitrariness is commonly seen as a major concept in Saussure’s thought, and it even receives the status of a “principle” in his theory. It is not only the characteristic feature of the relation between ... [more ▼]Arbitrariness is commonly seen as a major concept in Saussure’s thought, and it even receives the status of a “principle” in his theory. It is not only the characteristic feature of the relation between the signifier and the signified (the semiological relation is arbitrary), but moreover it is constitutive of this very relation (the relation is semiological because it is arbitrary; there is a so-called “semiological relation” established between a signifier and a signified because of the principle of arbitrariness). And when linguists and other Saussurean interpreters comment on the concept of arbitrariness, they usually imply a binary relation: the semiological relation is arbitrary due to the fact that the signifier is arbitrarily chosen vis-à-vis the signified, and vice versa. I will be questioning the latter assertion in this paper. In my opinion, the symmetry of the semiological relation has not been properly demonstrated. The signifier can be seen as arbitrary with regard to the signified, but no reason has been provided to recognize the converse. Instead a number of arguments can be put forth to see arbitrariness as a concept that implies a non-symmetrical relation. [less ▲]Detailed reference viewed: 18 (1 ULiège) Transient brightening of Jupiter’s aurora observed by the Hisaki satellite and Hubble Space Telescope during approach phase of the Juno spacecraftKimura, Tomoki; Nichols, J.D.; Gray, R.L. et alin Geophysical Research Letters (2017), 44In early 2014, continuous monitoring with the Hisaki satellite discovered transient auroral emission at Jupiter during a period when the solar wind was relatively quiet for a few days. Simultaneous ... [more ▼]In early 2014, continuous monitoring with the Hisaki satellite discovered transient auroral emission at Jupiter during a period when the solar wind was relatively quiet for a few days. Simultaneous imaging made by the Hubble Space Telescope (HST) suggested that the transient aurora is associated with a global magnetospheric disturbance that spans from the inner to outer magnetosphere. However, the temporal and spatial evolutions of the magnetospheric disturbance were not resolved because of the lack of continuous monitoring of the transient aurora simultaneously with the imaging. Here we report the coordinated observation of the aurora and plasma torus made by Hisaki and HST during the approach phase of the Juno spacecraft in mid‐2016. On day 142, Hisaki detected a transient aurora with a maximum total H2 emission power of ~8.5 TW. The simultaneous HST imaging was indicative of a large “dawn storm,” which is associated with tail reconnection, at the onset of the transient aurora. The outer emission, which is associated with hot plasma injection in the inner magnetosphere, followed the dawn storm within less than two Jupiter rotations. The monitoring of the torus with Hisaki indicated that the hot plasma population increased in the torus during the transient aurora. These results imply that the magnetospheric disturbance is initiated via the tail reconnection and rapidly expands toward the inner magnetosphere, followed by the hot plasma injection reaching the plasma torus. This corresponds to the radially inward transport of the plasma and/or energy from the outer to the inner magnetosphere. [less ▲]Detailed reference viewed: 25 (0 ULiège) D. W. Vasaco and A. Datta-Gupta: Subsurface Fluid Flow and Imaging—With Applications for Hydrology, Reservoir Engineering and GeophysicsDassargues, Alain in Mathematical Geosciences (2017)Book reviewDetailed reference viewed: 33 (2 ULiège) Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesisRosewick, Nicolas; Durkin, Keith ; Artesi, Maria et alin Nature Communications (2017), 8Detailed reference viewed: 45 (7 ULiège) Effects of preference and sensory modality on behavioral reaction in patients with disorders of consciousnessHeine, Lizette ; Tillmann, Barbara; Hauet, Marjolaine et alin Brain Injury (2017)Background: Reliable evaluation of patients with unresponsive wakefulness syndrome (UWS) or in a minimally conscious state (MCS) remains a major challenge. It has been suggested that the expression of ... [more ▼]Background: Reliable evaluation of patients with unresponsive wakefulness syndrome (UWS) or in a minimally conscious state (MCS) remains a major challenge. It has been suggested that the expression of residual cerebral function could be improved by allowing patients to listen to their favourite music. However, the potential effect of music on behavioural responsiveness, as well as the effect of preferred stimuli in other sensory modalities (e.g. olfaction), remain poorly understood. Objective: The aim of our study was to investigate the effect of sensory modality (auditory versus olfactory) and preference (preferred versus neutral) of the test stimuli on patients’ subsequent performance on the Coma Recovery Scale-Revised (CRS-R). Research design: Within-subject design because of inter-individual differences between patients. Methods and procedures: We studied four items from the CRS-R (visual pursuit using a mirror, auditory localization of the own name and two movements to command) in 13 patients (7 MCS; 6 UWS). Main outcomes and results: Auditory stimuli triggered higher responsiveness compared to olfactory stimuli, and preferred stimuli were followed by higher scores than did neutral stimuli. Conclusions: Findings suggest that preferred auditory stimuli at the bedside contribute to the expression of residual function and could improve the diagnostic assessment. [less ▲]Detailed reference viewed: 24 (7 ULiège) Controlled synthesis of fluorinated copolymers via cobalt-mediated radical copolymerization of perfluorohexylethylene and vinyl acetateDemarteau, Jérémy ; Améduri, Bruno; Ladmiral, Vincent et alin Macromolecules (2017), 50(10), 3750-3760Designing novel polyfluoropolymer architectures is attractive for the development of new applications, such as advanced coatings, purification membranes, or materials for energy. Nevertheless, controlling ... [more ▼]Designing novel polyfluoropolymer architectures is attractive for the development of new applications, such as advanced coatings, purification membranes, or materials for energy. Nevertheless, controlling the radical polymerization of fluoroalkenes is very challenging due to the high reactivity of the propagating fluorinated macroradicals. This study aims at exploring the controlled copolymerization of perfluoro- hexylethylene (PFHE) and vinyl acetate (VAc) in order to prepare a range of well-defined statistical poly(PFHE-stat-VAc) copolymers with different compositions. Cobalt-mediated radical polymerization demonstrated to be active at 40 °C starting from an alkylcobalt(III) initiator, and copolymers with a fluorinated monomer content as high as ca. 80 wt % were successfully prepared. Reactivity ratios were determined to be rVAc = 0.18 and rPFHE = 0 at 40 °C and emphasized a clear tendency for alternation. Unprecedented PFHE/VAc containing block copolymers were also prepared via a single-step approach or through sequential copolymerizations. Finally, hydrolysis of the pendant ester groups of these copolymers led to the corresponding fluorinated copolymers bearing vinyl alcohol (VOH). A preliminary solution behavior study, carried out by dynamic light scattering and transmission electron microscopy on block copolymers composed of PFHE and VAc or VOH units, evidenced a marked amphiphilicity of the copolymer composed of an extremely hydrophobic PFHE block associated with a highly hydrophilic PVOH segment. [less ▲]Detailed reference viewed: 41 (6 ULiège) Puzzling Out Synaptic Vesicle 2 Family Members FunctionsBartholomé, Odile ; Van Den Ackerveken, Priscilla ; Sanchez Gil, Judit et alin Frontiers in Molecular Neuroscience (2017)Detailed reference viewed: 9 (2 ULiège) Semen quality and some factors affecting the semen quality of Dong Tao chickenNguyen Van Duy, ; Do Thi, Hue; Vu Dinh, Tonin Journal of Sciences Agricultural Viet Nam (2017), 15(5), 589-604The study was conducted on 11 Dong Tao cocks (8-10 months) at the chicken farm in Faculty of Animal Science, Vietnam National University of Agriculture to assess the semen quality and some factors ... [more ▼]The study was conducted on 11 Dong Tao cocks (8-10 months) at the chicken farm in Faculty of Animal Science, Vietnam National University of Agriculture to assess the semen quality and some factors affecting semen quality of Dong Tao cocks (individual, time of semen exploitation and storage condition) from January to December, 2016. The results showed that Dong Tao cocks had good quality of semen with average ejaculate volume, motility and sperm concentration were 0.48 ml, 80.1%, 2.57 billion sperms/ml semen, respectively; pH: 7.45; semen color: 2.6 (between white to milk colors); activity of sperms: 3.99 (well moving with waves at moderate level). The individual factor affected all criterias of semen quality (P<0.05). Sperm motility and concentration that collected in the morning were higher than that collected in the afternoon (P<0.05). Sperm motility of diluted semen and keeping in the cold storage temperature (2-10oC) was higher (P <0.05) than semen keeping in normal temperature. [less ▲]Detailed reference viewed: 16 (2 ULiège) Healing Effect of Controlled Anti-Electromigration on Conventional and High-Tc Superconducting NanowiresBaumans, Xavier ; Lombardo, Joseph ; Brisbois, Jérémy et alin Small : Nano Micro (2017), 1700384The electromigration process has the potential capability to move atoms one by one when properly controlled. It is therefore an appealing tool to tune the cross section of monoatomic compounds with ... [more ▼]The electromigration process has the potential capability to move atoms one by one when properly controlled. It is therefore an appealing tool to tune the cross section of monoatomic compounds with ultimate resolution or, in the case of polyatomic compounds, to change the stoichiometry with the same atomic precision. As demonstrated here, a combination of electromigration and anti-electromigration can be used to reversibly displace atoms with a high degree of control. This enables a fine adjustment of the superconducting properties of Al weak links, whereas in Nb the diffusion of atoms leads to a more irreversible process. In a superconductor with a complex unit cell (La 2−x Ce x CuO 4 ), the electromigration process acts selectively on the oxygen atoms with no apparent modification of the structure. This allows to adjust the doping of this compound and switch from a superconducting to an insulating state in a nearly reversible fashion. In addition, the conditions needed to replace feedback controlled electromigration by a simpler technique of electropulsing are discussed. These findings have a direct practical application as a method to explore the dependence of the characteristic parameters on the exact oxygen content and pave the way for a reversible control of local properties of nanowires. [less ▲]Detailed reference viewed: 20 (14 ULiège) The prevention of fragility fractures in patients with non-metastatic prostate cancer: a position statement by the international osteoporosis foundation.CIANFEROTTI, L; BERTOLDO, F; CARINI, M et alin Oncotarget (2017)Androgen deprivation therapy is commonly employed for the treatment of nonmetastatic prostate cancer as primary or adjuvant treatment. The skeleton is greatly compromised in men with prostate cancer ... [more ▼]Androgen deprivation therapy is commonly employed for the treatment of nonmetastatic prostate cancer as primary or adjuvant treatment. The skeleton is greatly compromised in men with prostate cancer during androgen deprivation therapy because of the lack of androgens and estrogens, which are trophic factors for bone. Men receiving androgen deprivation therapy sustain variable degrees of bone loss with an increased risk of fragility fractures. Several bone antiresorptive agents have been tested in randomized controlled trials in these patients. Oral bisphosphonates, such as alendronate and risedronate, and intravenous bisphosphonates, such as pamidronate and zoledronic acid, have been shown to increase bone density and decrease the risk of fractures in men receiving androgen deprivation therapy. Denosumab, a fully monoclonal antibody that inhibits osteoclastic-mediated bone resorption, is also effective in increasing bone mineral density and reducing fracture rates in these patients. The assessment of fracture risk, T-score and/or the evaluation of prévalent fragility fractures are mandatory for the selection of patients who will benefit from antiresorptive therapy. In the future, new agents modulating bone turnover and skeletal muscle metabolism will be available for testing in these subjects. [less ▲]Detailed reference viewed: 23 (3 ULiège) Defining thermal comfort boundaries for heating and cooling demand estimation in Iran's urban settlementsRoshan, GhR.; Farrokhzad, M.; Attia, Shady in Building & Environment (2017), 121Iran has diverse climate variability, comfort boundaries for each geographic region must be defined in order to present current architectural design recommendations and proper mechanical systems design to ... [more ▼]Iran has diverse climate variability, comfort boundaries for each geographic region must be defined in order to present current architectural design recommendations and proper mechanical systems design to meet building's heating and cooling energy demand. Therefore, two components of the temperature and relative humidity of 148 stations with the longest common statistical period of twenty years (1994–2014), which have been in daily scale were selected to calibrate and redefine the thermal boundary conditions in Iran. Givoni chart was used to define and visualize the bioclimatic conditions in buildings. The results of this study indicate that only 18% of the 148 stations days, falls in the thermal comfort bioclimatic conditions. After calibration of the base comfort temperature, we found that the upper threshold of this component varies from at least 22.62 °C for Ardebil to 25.94 °C for Dorudzan station and the low threshold of this component belongs to Ardebil with at least 20.13 °C up to its maximum value with 22 °C which belongs to Dorudzan. Spatial distribution of cooling and heating days show that their maximum threshold has been for cores in Northeastern half of Iran, Iran's Western half and some Central parts of Iran and the minimum threshold of these two components belongs to the beaches of north and south of the country. The findings present updated thermal comfort boundaries that can be used by architects, engineers and policy makers to achieve, in turn, more energy efficient homes and high quality indoor and outdoor living environments. [less ▲]Detailed reference viewed: 58 (10 ULiège) First Characterisation of Volatile Organic Compounds Emitted by Banana PlantsBerhal, Chadi ; De Clerck, Caroline ; Fauconnier, Marie-Laure et alin Scientific Reports (2017)Banana (Musa sp.) ranks fourth in term of worldwide fruit production, and has economical and nutritional key values. The Cavendish cultivars correspond to more than 90% of the production of dessert banana ... [more ▼]Banana (Musa sp.) ranks fourth in term of worldwide fruit production, and has economical and nutritional key values. The Cavendish cultivars correspond to more than 90% of the production of dessert banana while cooking cultivars are widely consumed locally around the banana belt production area. Many plants, if not all, produce Volatile Organic Compounds (VOCs) as a means of communication with their environment. Although flower and fruit VOCs have been studied for banana, the VOCs produced by the plant have never been identified despite their importance in plant health and development. A volatile collection methodology was optimized to improve the sensitivity and reproducibility of VOCs analysis from banana plants. We have identified 11 VOCs for the Cavendish, mainly (E,E)-α-farnesene (87.90 ± 11.28 ng/μl), methyl salicylate (33.82 ± 14.29) and 6-methyl-5-hepten-2-one (29.60 ± 11.66), and 14 VOCs for the Pacific Plantain cultivar, mainly (Z,E)-α-farnesene (799.64 ± 503.15), (E,E)-α-farnesene (571.24 ± 381.70) and (E) β ocimene (241.76 ± 158.49). This exploratory study paves the way for an in-depth characterisation of VOCs emitted by Musa plants. [less ▲]Detailed reference viewed: 62 (7 ULiège) Straightforward prediction of the Ni1−xO layers stoichiometry by using optical and electrochemical measurementsManceriu, Laura ; Colson, Pierre ; Maho, Anthony et alin Journal of Physics : D Applied Physics (2017), 50In this study, we propose a straightforward method for x determination in sub-stoichiometric nickel oxide (Ni1−xO) films prepared by ultrasonic spray pyrolysis on fluor-tin oxide (FTO) substrates by ... [more ▼]In this study, we propose a straightforward method for x determination in sub-stoichiometric nickel oxide (Ni1−xO) films prepared by ultrasonic spray pyrolysis on fluor-tin oxide (FTO) substrates by varying the post-deposition thermal treatment. The Ni3+ concentration, the flat band potential (Φfb) and the open circuit potential (Voc) were determined by electrochemical impedance analysis in aqueous media and correlated to the transmission of Ni1−xO films. An x-ray photoelectron spectroscopy study was also performed to quantify the amount of Ni3+ in the films and compare it with the one determined by electrochemical analysis. The electrochromic behavior of the Ni1−xO films in non-aqueous electrolyte was investigated as well. With increasing Ni3+ concentration the films became more brownish and more conductive, both Voc and Φfb values increased. Calibration curves of transmission at 550 nm or open circuit potential versus carrier concentration were plotted and allowed the prediction of x in an unknown Ni1−xO sample. The Ni1−xO films characterized by the highest Ni3+ concentration have a darker colored state but lower transmission modulation, due to their reduced specific surface and increased crystallinity. [less ▲]Detailed reference viewed: 22 (4 ULiège) Effects of isolated versus combined learning enactments in an online courseVerpoorten, Dominique ; Westera, Wim; Specht, Marcusin International Journal of Technology Enhanced Learning (2017), 9(2), 169-185In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course under three possible conditions: no/free/question-based digital annotations ... [more ▼]In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course under three possible conditions: no/free/question-based digital annotations. Results show no difference in performance between groups when annotation behaviour is considered in isolation. However, analyses conducted within treatments provide indications of a positive impact on performance when annotation rates are taken into consideration, and coupled with other enactments tracked in the course. Combined in engagement profiles (Learning DNAs), these enactments suggest that what makes active learning efficient might be an ongoing crisscrossing between a firstorder learning activity (the study of the course) and a series of second order activities, such as making notes. Students who manage to coordinate these activities at a higher rate perform better. This observation opens a line of reasoning about what determines the quality of a mental engagement in a learning task, in terms of balance and rotation of cognitive and metacognitive operations. [less ▲]Detailed reference viewed: 56 (16 ULiège) Preferred Orientation Contribution to the Anisotropic Normal State Resistivity in Superconducting Melt-Cast Processed Bi2Sr2CaCu2O8+δDellicour, Aline ; Vertruyen, Bénédicte ; Rikel, M O et alin Materials (2017), 10We describe how the contribution of crystallographic texture to the anisotropy of the resistivity of polycrystalline samples can be estimated by averaging over crystallographic orientations through a ... [more ▼]We describe how the contribution of crystallographic texture to the anisotropy of the resistivity of polycrystalline samples can be estimated by averaging over crystallographic orientations through a geometric mean approach. The calculation takes into account the orientation distribution refined from neutron diffraction data and literature values for the single crystal resistivity tensor. The example discussed here is a melt-cast processed Bi2Sr2CaCu2O8+ (Bi-2212) polycrystalline tube in which the main texture component is a <010> fiber texture with relatively low texture strength. Experimentally-measured resistivities along the longitudinal, radial, and tangential directions of the Bi-2212 tube were compared to calculated values and found to be of the same order of magnitude. Calculations for this example and additional simulations for various texture strengths and single crystal resistivity anisotropies confirm that in the case of highly anisotropic phases such as Bi-2212, even low texture strengths have a significant effect on the anisotropy of the resistivity in polycrystalline samples. [less ▲]Detailed reference viewed: 16 (0 ULiège) Risk Assessment of Florists Exposed to Pesticide Residues through Handling of Flowers and Preparing BouquetsToumi, Khaoula ; Laure, Joly; Vleminckx, Christiane et alin International Journal of Environmental Research and Public Health (2017), 14(5)Abstract: Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty ... [more ▼]Abstract: Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty volunteer florists located in Namur Province and in the Brussels Capital Region of Belgium in order to assess their potential dermal exposure to dislodgeable pesticide residues transferred from flowers to hands. Two pairs of cotton gloves were worn during two consecutive half days while handling flowers and preparing bouquets (from min 2 h to max 3 h/day). The residual pesticide deposits on the glove samples were extracted with a multi-residue Quick Easy Cheap Effective Rugged Safe (QuEChERS) method and analyzed by a combination of gas and liquid chromatography tandem mass spectrometry (GC-MS/MS and LC-MS/MS) by an accredited laboratory. A total of 111 active substances (mainly insecticides and fungicides) were detected, with an average of 37 active substances per sample and a total concentration per glove sample of 22.22 mg/kg. Several predictive levels of contamination were considered to assess the risk. The potential dermal exposures (PDE) of florists were estimated at the average, for different percentiles, and at the maximum concentration of residues in samples. At the PDE P90 and at the PDEMAX (or worst case) values, three and five active substances respectively exceed the Acceptable Operator Exposure Level (AOEL), indicating risk situations. For the systemic exposure (SE), one active substance (clofentezine) exceeds the AOEL at the P90 predictive level. In the worst case, SEMAX (at the maximum concentrations), four active substances (clofentezine, famoxadone, methiocarb, and pyridaben) exceed their respective AOEL values. Among the 14 most frequently detected active substances, two have SEMAX values exceeding the AOEL. Exposure could be particularly critical for clofentezine with an SEMAX value four times higher than the AOEL (393%). The exposure of florists appeared to be an example of a unique professional situation in which workers are exposed regularly to both a very high number of toxic chemicals and rather high concentration levels. Therefore the priority should be to raise the level of awareness among the florists who must change their habits and practices if they want to minimize their exposure. [less ▲]Detailed reference viewed: 39 (4 ULiège) Comparative Feeding Ecology of Cardinalfishes (Apogonidae) at Toliara Reef, MadagascarFrederich, Bruno ; Michel, Loïc ; Zaeytydt, Esther et alin Zoological Studies (2017), 56(10), 1-14Despite their importance in coral reef ecosystem function and trophodynamics, the trophic ecology of nocturnal fishes (e.g. Apogonidae, Holocentridae, Pempheridae) is by far less studied than diurnal ones ... [more ▼]Despite their importance in coral reef ecosystem function and trophodynamics, the trophic ecology of nocturnal fishes (e.g. Apogonidae, Holocentridae, Pempheridae) is by far less studied than diurnal ones. The Apogonidae (cardinalfishes) include mostly carnivorous species and evidence of trophic niche partitioning among sympatric cardinalfishes is still limited. The present study combines stomach contents and stable isotope analyses to investigate the feeding ecology of an assemblage of eight cardinalfishes from the Great Reef of Toliara (SW Madagascar). δ13C and δ15N of fishes ranged between -17.49‰ and -10.03‰ and between 6.28‰ and 10.74‰, respectively. Both stomach contents and stable isotopes showed that they feed on planktonic and benthic animal prey in various proportions. Previous studies were able to group apogonids in different trophic categories but such a discrimination is not obvious here. Large intra-specific variation in the stomach contents and temporal variation in the relative contribution of prey to diet support that all apogonids should be considered as generalist, carnivorous fishes. However the exploration of the isotopic space revealed a clear segregation of isotopic niches among species, suggesting a high level of resource partitioning within the assemblage. According to low inter-specific variation in stomach content compositions, we argue that the differences in isotopic niches could be driven by variation in foraging locations (i.e. microhabitat segregation) and physiology among species. Our temporal datasets demonstrate that the trophic niche partitioning among cardinalfishes and the breadth of their isotopic niches are dynamic and change across time. Factors driving this temporal variation need to be investigated in further studies. [less ▲]Detailed reference viewed: 75 (4 ULiège) Recovering unlawful advantages in the context of EU State aid tax ruling investigationsVan Cleynenbreugel, Pieter in Market and Competition Law Review (2017), 1(1), 15-48The European Commission has recently begun to focus increasingly on the compatibility of Member States’ tax ruling procedures with EU State aid law. In that respect, it has ordered the recovery of ... [more ▼]The European Commission has recently begun to focus increasingly on the compatibility of Member States’ tax ruling procedures with EU State aid law. In that respect, it has ordered the recovery of unlawfully granted advantages through those procedures. This article examines to what extent the application of EU law principles of legitimate expectations and legal certainty are to take stock in State aid recovery proceedings of this particular legal certainty-enhancing and legitimate expectationscreating tax ruling context. It additionally questions whether recovery in this particular context should be tailored to the specific national ruling framework having resulted in the advantage granted in violation of Article 107 TFEU [less ▲]Detailed reference viewed: 13 (1 ULiège) How does policy learning occur? The case of Belgian mental health care reformsThunus, Sophie ; Schoenaers, Frédéric in Policy and Society (2017)This article asks how policy learning is achieved and whether and how it impacts on policy change. By drawing on the empirical case of Belgian mental health reforms, it shows that policy learning occurs ... [more ▼]This article asks how policy learning is achieved and whether and how it impacts on policy change. By drawing on the empirical case of Belgian mental health reforms, it shows that policy learning occurs through the very practice of policy-making. In-depth analyses of the process of preparing and devising, a current reform of mental health care delivery, called Reform 107, evidence that the transformation of policy learning – through verbal expression, inscription in documents or enactment in social situations such as meetings – is crucial to its impact on policy change. A phenomenological approach to knowledge in policy helps to perceive and describe the transformation of policy learning through practical actions and interactions involved in devising policy change. Analytically, looking at this transformation entails shifting the focus from big and visible changes in policy objectives and instruments to micro policy practices such as meeting and writing documents. Placing the focus on micro policy practices should not lead, however, to a disregard for the social context in which they develop. The interactionist concept of linked ecologies provides the means to consider social regulations influencing policy learning without underestimating their very ephemeral and contingent nature [less ▲]Detailed reference viewed: 53 (8 ULiège) Molecular insights into cassava brown streak virus susceptibility and resistance by profiling of the early host response.Anjanappa, Ravi B.; Mehta, Devang; Okoniewski, Michal J. et alin Molecular Plant Pathology (2017)Cassava brown streak viruses (CBSVs) are responsible for significant cassava yield losses in eastern sub-Saharan Africa. To study the possible mechanisms of plant resistance to CBSVs we inoculated CBSV ... [more ▼]Cassava brown streak viruses (CBSVs) are responsible for significant cassava yield losses in eastern sub-Saharan Africa. To study the possible mechanisms of plant resistance to CBSVs we inoculated CBSV-susceptible and -resistant cassava varieties with a mixed infection of CBSVs using top-cleft grafting. Transcriptome profiling of the two cassava varieties was performed at the earliest time-point of full infection (28 days after grafting) in the susceptible scions. The expression of genes encoding proteins in RNA silencing, salicylic acid pathways and callose deposition was altered in the susceptible cassava variety but transcriptional changes were limited in the resistant variety. In total, the expression of 585 genes was altered in the resistant variety as compared to 1292 in the susceptible variety. Transcriptional changes led to activation of beta-1,3-glucanase enzymatic activity and reduction of callose deposition in the susceptible cassava variety. Time course analysis also showed that CBSV replication in susceptible cassava induced a strong up-regulation of RDR1, a gene previously reported to be a susceptibility factor in other potyvirus-host pathosystems. The differences in transcriptional responses to CBSV infection indicated that susceptibility involves restriction of callose deposition at plasmodesmata. Aniline blue staining of callose deposits also indicated that the resistant variety displays a moderate but significant increase in callose deposition at the plasmodesmata. Transcriptome data suggests that resistance does not involve typical anti-viral defence responses (i.e. RNA silencing and salicylic acid). A meta-analysis of the current RNA-seq dataset and selected potyvirus-host and virus-cassava RNA-seq datasets revealed that the conservation of the host response across pathosystems is restricted to genes involved in developmental processes. This article is protected by copyright. All rights reserved. [less ▲]Detailed reference viewed: 14 (1 ULiège) Dynamic of soil drying close to saturation: What can we learn from a comparison between X-ray computed microtomography and the evaporation method?Parvin, Nargish ; Beckers, Eléonore ; Plougonven, Erwan et alin Geoderma (2017), 302The soil water retention curve (SWRC) is a unique relationship between water content and soil water potential. SWRC in near saturation gives the dimension of soil macroporosity which plays an important ... [more ▼]The soil water retention curve (SWRC) is a unique relationship between water content and soil water potential. SWRC in near saturation gives the dimension of soil macroporosity which plays an important role in water translocation into soil. Thus, the accurate measurement of SWRC is crucial. The aim of this study is to compare SWRC obtained through two different methods: X-ray computed microtomography (X-ray CT) and evaporation method by HYPROP device. Three different depths (0–10, 25–30 and 45–60 cm) are considered for soil sampling. The results showed significant differences in SWRC between the techniques. The SWRC from X-ray CT showed more volumetric water content at 25–30 cm (0.044) and 45–60 cm (0.024) than evaporation at saturation (0 kPa) in cases where the macroporosity was higher. Macropores may have connections with neighbouring pores of smaller sizes. Hence we assume that these pores can be observed through X-ray CT but cannot be evaluated by evaporation. As macropores with narrow opening do not evaporate at very low tension. These pores therefore got empty at relatively higher tension. Consequently, SWRC near saturation appeared rather flatter with the evaporation method where the X-ray CT presented deviation. Accordingly, interpretation of macro pores from SWRC through evaporation method would give comparatively smaller volume of macropores than they really are. Pore morphology and other hydraulic functions of soil, for example, mean connection surface of pores, hydraulic conductivity, and the efficiency of water conducting macropores also support the X-ray CT findings. [less ▲]Detailed reference viewed: 39 (9 ULiège) "Sulla scia di Agnolo Bronzino, Alessandro Allori sodale di Benedetto Varchi. Un ritratto ‘misconosciuto’ del letterato e un suo sonetto inedito"Geremicca, Antonio in LaRivista. Études culturelles italiennes Sorbonne Universités (2017), 5Detailed reference viewed: 21 (0 ULiège) Study of Meta-analysis strategies for network inference using information-theoretic approachesPham, Cam Ngoc ; Haibe-Kains; Bellot, Pau et alin BioData Mining (2017)Detailed reference viewed: 23 (5 ULiège) Adipsic diabetes insipidus revealing a bifocal intracranial germinomaKREUTZ, Julie ; Potorac, Iulia ; LUTTERI, Laurence et alin Annales d'Endocrinologie (2017)Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the ... [more ▼]Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. We describe the diagnostic procedures and the three-year follow-up of this patient. Management of intracranial germ-cell tumors is made complex by the wide range of histological features. Although germinomas have a generally better prognosis than most nongerminomatous tumors, they can have severe or even life-threatening presentations. Adipsic diabetes insipidus is one such severe presentation and its rarity can make it difficult to recognize and manage. Awareness of this potential entity is therefore important for clinical practice. Le diabète insipide adipsique est une des rares complications des tumeurs intracrâniennes. Il associe une baisse de la sécrétion d’hormone antidiurétique à une perte de la sensation de soif et ilsignale souvent la présence d’une lésion qui atteint ou envahit l’hypothalamus. Nous présentons le cas d’une patiente avec un germinome intracrânien bifocal diagnostiqué devant un tableau de diabète insipide adipsique. À notre connaissance, il s’agit du premier cas de la littérature d’un diabète insipide révélant un germinome intracrânien. La prise en charge des tumeurs germinales intracrâniennes est complexe du fait des phénotypes histologiques divers. Bien que les germinomes ont généralement un meilleur pronostic que les tumeurs non-germinomateuses, ils peuvent avoir des présentations sévères. Le diabète insipide adipsique est une de ces présentations sévères et sa rareté peut rendre son diagnostic et sa prise en charge difficiles. La reconnaissance de cette entité potentielle est, dès lors, importante pour la pratique clinique [less ▲]Detailed reference viewed: 46 (7 ULiège) AIP mutations and gigantismRostomyan, Liliya ; Potorac, Iulia ; BECKERS, Pablo et alin Annales d'Endocrinologie (2017)AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated ... [more ▼]AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤ 30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases enables timely clinical evaluation and treatment, thereby improving outcomes in terms of excessive linear growth and acromegaly comorbidities. Bien que les mutations du gène AIP soient rares dans les cas d’acromégalie sporadique, l’importance de ces mutations est établie dans des populations spécifiques de patients telles que les patients qui souffrent de familial isolated pituitary adenomas (FIPA), de gigantisme ou qui présentent un macroadénome hypophysaire avant l’âge de 30 ans. C’est dans le gigantisme qu’elles sont le plus fréquemment retrouvées (29 % des géants présentent une mutation de ce gène). Dans ces populations, nos données suggèrent qu’il est utile de réaliser un screening ciblé pour les mutations ou délétions du gène AIP. La reconnaissance précoce des cas d’acromégalie et de gigantisme permet une évaluation clinique et un traitement appropriés de ces patients. Elle contribue à améliorer les résultats des traitements tant en terme de croissance excessive qu’en ce qui concerne les comorbidités liées à l’acromégalie. [less ▲]Detailed reference viewed: 45 (20 ULiège) From the shortest to the tallestBeckers, Albert in Annales d'Endocrinologie (2017), 78Detailed reference viewed: 14 (2 ULiège) Cow milk coagulation: process description, variation factors and evaluation methodologies. A review.Troch, Thibault; Lefebure, Emilie ; Baeten, Vincent et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21Introduction. For dairy producers who want to transform their milk, the ability of milk to coagulate is an important parameter. It makes it possible to transform milk into cheese. Therefore, it is ... [more ▼]Introduction. For dairy producers who want to transform their milk, the ability of milk to coagulate is an important parameter. It makes it possible to transform milk into cheese. Therefore, it is necessary to understand the coagulation process and the techniques to measure it in order to achieve the best transformation performance. The objective of this review is to describe the milk coagulation process, the factors influencing it and the methods for measuring the coagulation of milk at lab level. Literature. The processing of milk into cheese involves three steps: coagulation, dewatering and refining. Coagulation is a key step which involves the use of rennet and depends on several parameters (pH, calcium content, temperature, etc.). Some milks never coagulate. To measure the coagulation ability of milk and identify different parameters in milk coagulation properties, the Formagraph, the computerized renneting meter and the Optigraph have been developed (reference methods). Equations have been developed using infrared spectrometry to predict the parameters obtained by the reference methods. Conclusions. The milk coagulation mechanism is known. However, the issue of non-coagulating milk persists and represents a real challenge in terms of yield. The use of infrared is a faster alternative to reference methods that measure the coagulation properties of milk, but still requires an improvement in prediction equations. [less ▲]Detailed reference viewed: 52 (4 ULiège) Du militantisme à la commémoration. Un monument en hommage à l’immigration espagnole à LiègeMolina Marmol, Maïté in Communications (2017), 100Detailed reference viewed: 15 (2 ULiège) Spray droplet impaction outcomes for different plant species and spray formulationsMassinon, Mathieu ; De Cock, Nicolas ; Forster, W. Alison et alin Crop Protection (2017), 99A track-sprayer combined with a high-speed camera were used to visualize and identify droplet impaction outcomes for three formulations (water, 0.1% LI 700® (lecithin, a mixture of soya oils, propionic ... [more ▼]A track-sprayer combined with a high-speed camera were used to visualize and identify droplet impaction outcomes for three formulations (water, 0.1% LI 700® (lecithin, a mixture of soya oils, propionic acid and surfactants) in water and 0.1% Pulse® (non-ionic surfactant, trisiloxane ethoxylate) in water) on four plant species (bean (Vicia faba L.), avocado (Persea americana L.), barnyard grass (Echinochloa crus-galli L. P. Beauv.) and cabbage (Brassica oleracea L.)) selected to represent a wide range of leaf surface characters. Droplet sizes and velocities were measured by image analysis and a multiple hypothesis tracking algorithm. Impaction outcomes were categorized into adhesion, bounce, or shatter. The probability of each outcome was estimated from logistic regression models related to the dimensionless Weber number. This approach is in contrast to various deterministic threshold criteria for droplet bounce or shatter that have been used to model droplet impaction events on leaves. It also provides a simple visual and numerical presentation of the complexity of impaction processes, and the relative influence of leaf surface character versus formulation for droplets with different impaction energies. [less ▲]Detailed reference viewed: 43 (10 ULiège) Model-based classification of CPT data and automated lithostratigraphic mapping for high-resolution characterization of a heterogeneous sedimentary aquiferRogiers, Bart; Mallants, Dirk; Batelaan, Okke et alin PLoS ONE (2017), 12(5), 0176656Cone penetration testing (CPT) is one of the most efficient and versatile methods currently available for geotechnical, lithostratigraphic and hydrogeological site characterization. Currently available ... [more ▼]Cone penetration testing (CPT) is one of the most efficient and versatile methods currently available for geotechnical, lithostratigraphic and hydrogeological site characterization. Currently available methods for soil behaviour type classification (SBT) of CPT data however have severe limitations, often restricting their application to a local scale. For parameterization of regional groundwater flow or geotechnical models, and delineation of regional hydro- or lithostratigraphy, regional SBT classification would be very useful. This paper investigates the use of model-based clustering for SBT classification, and the influence of different clustering approaches on the properties and spatial distribution of the obtained soil classes. We additionally propose a methodology for automated lithostratigraphic mapping of regionally occurring sedimentary units using SBT classification. The methodology is applied to a large CPT dataset, covering a groundwater basin of ~60 km2 with predominantly unconsolidated sandy sediments in northern Belgium. Results show that the model-based approach is superior in detecting the true lithological classes when compared to more frequently applied unsupervised classification approaches or literature classification diagrams. We demonstrate that automated mapping of lithostratigraphic units using advanced SBT classification techniques can provide a large gain in efficiency, compared to more time-consuming manual approaches and yields at least equally accurate results. [less ▲]Detailed reference viewed: 15 (1 ULiège) Polyphenolic profile and biological activities of the leaves and aerial parts of Echinocystis lobata (Michx.) Torr. et A.Gray (Cucurbitaceae)Ielciu, Irina-Ioana ; Vlase, Laurian; Frederich, Michel et alin Farmacia (2017), 65(2), 179-183The aim of the present study consisted in the quantification of the polyphenols in leaves and aerial parts of Echinocystis lobata (Michx.) Torr. et A.Gray and testing its biological potential. Analysis of ... [more ▼]The aim of the present study consisted in the quantification of the polyphenols in leaves and aerial parts of Echinocystis lobata (Michx.) Torr. et A.Gray and testing its biological potential. Analysis of polyphenols was performed by a HPLC-MS method. Antioxidant activity of the extracts was tested by DPPH, CUPRAC, FRAP, TEAC, EPR and SNPAC assays. Cytotoxic activity was assessed on cancerous and healthy cell lines. Anti-plasmodial tests were performed on two strains of Plasmodium falciparum. Ethanolic extracts of E. lobata contain mainly p-coumaric acid, isoquercitrin, rutin, quercitrin and kaempferol. Biological assays showed a significant antioxidant effect and no cytotoxic and anti-plasmodial activity. These results offer a new perspective on E. lobata, proving it as an important source of antioxidant compounds. [less ▲]Detailed reference viewed: 53 (7 ULiège) Surrogate Generation and Evaluation for Biodiesel and Its Mixtures with Fossil DieselReiter, Anton M.; Schubert, Nikolai; Pfennig, Andreas et alin Energy & Fuels (2017), 31In this paper a precedently developed surrogate optimization algorithm for fossil fuels, which originally allowed simultaneous fitting of the true boiling point (TBP) curve, the liquid density at 15 °C ... [more ▼]In this paper a precedently developed surrogate optimization algorithm for fossil fuels, which originally allowed simultaneous fitting of the true boiling point (TBP) curve, the liquid density at 15 °C, and the cetane number, is refined toward its application to biodiesel and its mixtures with fossil diesel. For this purpose, the algorithm is extended (1) to also include fitting of the kinematic viscosity at 40 °C and (2) to account for peculiarities of biodiesel concerning its narrow boiling range and compensation of systematic errors of measured boiling curves. To illustrate these improvements, first, the algorithm is applied to property estimation and surrogate optimization of three different biodiesel fuels, for which surrogates consisting of one to three components are proposed. Second, a surrogate for a commercial European fossil diesel is calculated and produced in lab-scale. Finally, the algorithm is used for surrogate optimization and property estimation of mixtures of biodiesel and fossil diesel, considering fractions of biodiesel of 7% and 20% per volume. It is shown that the improved algorithm is capable of reliably optimizing surrogates for fuels containing both biogenic and fossil components. [less ▲]Detailed reference viewed: 13 (2 ULiège) An Improved On-line Contingency Screening for Power System Transient Stability AssessmentWeckesser, Johannes ; Jóhannsson, Hjörtur; Glavic, Mevludin et alin Electric Power Components & Systems (2017)This paper presents a contingency screening method and a framework for its on-line implementation. The proposed method carries out contingency screening and on-line stability assessment with respect to ... [more ▼]This paper presents a contingency screening method and a framework for its on-line implementation. The proposed method carries out contingency screening and on-line stability assessment with respect to first-swing transient stability. For that purpose, it utilizes the single machine equivalent method and aims at improving the prior developed contingency screening approaches. In order to determine vulnerability of the system with respect to a particular contingency, only one time-domain simulation needs to be performed. An early stop criteria is proposed so that in a majority of the cases the simulation can be terminated after a few hundred milliseconds of simulated system response. The method’s outcome is an assessment of the system’s stability and a classification of each considered contingency. The contingencies are categorized by exploiting parameters of an equivalent one machine infinite bus system. A novel island detection approach, appropriate for an on-line application since it utilizes efficient algorithms from graph theory and enables stability assessment of individual islands, is also introduced. The New England and New York system as well as the large-scale model of the Continental-European interconnected system are used to test the proposed method with respect to assessment accuracy and computation time. [less ▲]Detailed reference viewed: 30 (7 ULiège) π Aquarii is another γ Cassiopeiae objectNazé, Yaël ; Rauw, Grégor ; Cazorla, Constantin in Astronomy and Astrophysics (2017), 602The γ Cas category is a subgroup of Be stars displaying a strong, hard, and variable thermal X-ray emission. An XMM-Newton observation of π Aqr reveals spectral and temporal characteristics that clearly ... [more ▼]The γ Cas category is a subgroup of Be stars displaying a strong, hard, and variable thermal X-ray emission. An XMM-Newton observation of π Aqr reveals spectral and temporal characteristics that clearly make this Be star another member of the γ Cas category. Furthermore, π Aqr is a binary but, contrary to γ Cas, the nature of the companion to the Be star is known; it is a non-degenerate (stellar) object and its small separation from the Be star does not leave much room for a putative compact object close to the Be disk. This renders the accretion scenario difficult to apply in this system, and, hence, this discovery favors a disk-related origin for the γ Cas phenomenon. Based on observations collected with the ESA science mission XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA). [less ▲]Detailed reference viewed: 20 (4 ULiège) Identification of non-stationary dynamical systems using multivariate ARMA modelsBertha, Mathieu ; Golinval, Jean-Claude in Mechanical Systems and Signal Processing (2017), 88This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal ... [more ▼]This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal identification of linear time invariant systems, and time-varying autoregressive moving average models (TV-ARMA) for the identification of nonstationary systems, a time-varying ARMAV (TV-ARMAV) model is presented for the multivariate identification of time-varying systems. It results in the identification of not only the time-varying poles of the system but also of its respective time-varying mode shapes. The method is applied on a time-varying structure composed of a beam on which a mass is moving. [less ▲]Detailed reference viewed: 40 (8 ULiège) The 67P/Churyumov-Gerasimenko observation campaign in support of the Rosetta missionSnodgrass, C.; A'Hearn, M. F.; Aceituno, F. et alin Philosophical Transactions : Mathematical, Physical & Engineering Sciences (2017), 375We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/Churyumov-Gerasimenko ... [more ▼]We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/Churyumov-Gerasimenko from before Rosetta's arrival until nearly the end of the mission in September 2016. These provided essential data for mission planning, large-scale context information for the coma and tails beyond the spacecraft and a way to directly compare 67P with other comets. The observations revealed 67P to be a relatively `well-behaved' comet, typical of Jupiter family comets and with activity patterns that repeat from orbit to orbit. Comparison between this large collection of telescopic observations and the in situ results from Rosetta will allow us to better understand comet coma chemistry and structure. This work is just beginning as the mission ends-in this paper, we present a summary of the ground-based observations and early results, and point to many questions that will be addressed in future studies. This article is part of the themed issue 'Cometary science after Rosetta'. [less ▲]Detailed reference viewed: 34 (2 ULiège) An Optical and Infrared Photometric Study of the Young Open Cluster IC 1805 in the Giant H ii Region W4 †Sung, Hwankyung; Bessell, Michael S.; Chun, Moo-Young et alin Astrophysical Journal Supplement Series (2017), 230We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from ... [more ▼]We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from their location in the various color–color and color–magnitude diagrams, and the presence of Hα emission, mid-infrared excess emission, and X-ray emission. The reddening law toward IC 1805 is nearly normal (R [SUB] V [/SUB] = 3.05 ± 0.06). However, the distance modulus of the cluster is estimated to be 11.9 ± 0.2 mag (d=2.4+/- 0.2 kpc) from the reddening-free color–magnitude diagrams, which is larger than the distance to the nearby massive star-forming region W3(OH) measured from the radio VLBA astrometry. We also determined the age of IC 1805 ({τ }[SUB]{MSTO[/SUB]}=3.5 Myr). In addition, we critically compared the age and mass scale from two pre-main-sequence evolution models. The initial mass function with a Salpeter-type slope of Γ = ‑1.3 ± 0.2 was obtained and the total mass of IC 1805 was estimated to be about 2700 ± 200 {M}[SUB]ȯ [/SUB]. Finally, we found our distance determination to be statistically consistent with the Tycho-Gaia Astrometric Solution Data Release 1, within the errors. The proper motion of the B-type stars shows an elongated distribution along the Galactic plane, which could be explained by some of the B-type stars being formed in small clouds dispersed by previous episodes of star formation or supernova explosions. The optical imaging data in this article were gathered with two facilities: the AZT-22 1.5 m telescope at Maidanak Astronomical Observatory in Uzbekistan and the Canada–France–Hawaii Telescope (CFHT), which is operated by the National Research Council of Canada, the Institut National des Sciences de l’Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. [less ▲]Detailed reference viewed: 23 (3 ULiège) Multi-phase volcanic resurfacing at Loki Patera on Iode Kleer, K.; Skrutskie, M.; Leisenring, J. et alin Nature (La) (2017), 545The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera. The interior of this volcanic, caldera-like feature is composed of a warm, dark floor covering 21 ... [more ▼]The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera. The interior of this volcanic, caldera-like feature is composed of a warm, dark floor covering 21,500 square kilometres surrounding a much cooler central ‘island’. The temperature gradient seen across areas of the patera indicates a systematic resurfacing process, which has been seen to occur typically every one to three years since the 1980s. Analysis of past data has indicated that the resurfacing progressed around the patera in an anti-clockwise direction at a rate of one to two kilometres per day, and that it is caused either by episodic eruptions that emplace voluminous lava flows or by a cyclically overturning lava lake contained within the patera. However, spacecraft and telescope observations have been unable to map the emission from the entire patera floor at sufficient spatial resolution to establish the physical processes at play. Here we report temperature and lava cooling age maps of the entire patera floor at a spatial sampling of about two kilometres, derived from ground-based interferometric imaging of thermal emission from Loki Patera obtained on 8 March 2015 UT as the limb of Europa occulted Io. Our results indicate that Loki Patera is resurfaced by a multi-phase process in which two waves propagate and converge around the central island. The different velocities and start times of the waves indicate a non-uniformity in the lava gas content and/or crust bulk density across the patera. [less ▲]Detailed reference viewed: 34 (2 ULiège) Ambiguities in gravitational lens models: the density field from the source position transformationUnruh, Sandra; Schneider, Peter; Sluse, Dominique in Astronomy and Astrophysics (2017), 601Strong gravitational lensing is regarded as the most precise technique to measure the mass in the inner region of galaxies or galaxy clusters. In particular, the mass within one Einstein radius can be ... [more ▼]Strong gravitational lensing is regarded as the most precise technique to measure the mass in the inner region of galaxies or galaxy clusters. In particular, the mass within one Einstein radius can be determined with an accuracy of the order of a few percent or better, depending on the image configuration. For other radii, however, degeneracies exist between galaxy density profiles, precluding an accurate determination of the enclosed mass. The source position transformation (SPT), which includes the well-known mass-sheet transformation (MST) as a special case, describes this degeneracy of the lensing observables in a more general way. In this paper we explore properties of an SPT, removing the MST to leading order, that is we consider degeneracies which have not been described before. The deflection field \ahat(čθ) resulting from an SPT is not curl-free in general, and thus not a deflection that can be obtained from a lensing mass distribution. Starting from a variational principle, we construct lensing potentials that give rise to a deflection field \atilde, which differs from \ahat by less than an observationally motivated upper limit. The corresponding mass distributions from these "valid" SPTs are studied: their radial profiles are modified relative to the original mass distribution in a significant and non-trivial way, and originally axi-symmetric mass distributions can obtain a finite ellipticity. These results indicate a significant effect of the SPT on quantitative analyses of lens systems. We show that the mass inside the Einstein radius of the original mass distribution is conserved by the SPT; hence, as is the case for the MST, the SPT does not affect the mass determination at the Einstein radius. Furthermore, we analyse a degeneracy between two lens models, empirically found previously, and show that this degeneracy can be interpreted as being due to an SPT. Thus, degeneracies between lensing mass distributions are not just a theoretical possibility, but do arise in actual lens modeling. [less ▲]Detailed reference viewed: 20 (5 ULiège) The Spitzer search for the transits of HARPS low-mass planets. II. Null results for 19 planetsGillon, Michaël ; Demory, B.-O.; Lovis, C. et alin Astronomy and Astrophysics (2017), 601Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of ... [more ▼]Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of objects suitable for detailed characterization. Searching for the transits of the low-mass planets detected by Doppler surveys is a straightforward way to achieve this goal. Indeed, Doppler surveys target the most nearby main-sequence stars, they regularly detect close-in low-mass planets with significant transit probability, and their radial velocity data constrain strongly the ephemeris of possible transits. In this context, we initiated in 2010 an ambitious Spitzer multi-Cycle transit search project that targeted 25 low-mass planets detected by radial velocity, focusing mainly on the shortest-period planets detected by the HARPS spectrograph. We report here null results for 19 targets of the project. For 16 planets out of 19, a transiting configuration is strongly disfavored or firmly rejected by our data for most planetary compositions. We derive a posterior probability of 83% that none of the probed 19 planets transits (for a prior probability of 22%), which still leaves a significant probability of 17% that at least one of them does transit. Globally, our Spitzer project revealed or confirmed transits for three of its 25 targeted planets, and discarded or disfavored the transiting nature of 20 of them. Our light curves demonstrate for Warm Spitzer excellent photometric precisions: for 14 targets out of 19, we were able to reach standard deviations that were better than 50 ppm per 30 min intervals. Combined with its Earth-trailing orbit, which makes it capable of pointing any star in the sky and to monitor it continuously for days, this work confirms Spitzer as an optimal instrument to detect sub-mmag-deep transits on the bright nearby stars targeted by Doppler surveys. The photometric and radial velocity time series used in this work are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A117 [less ▲]Detailed reference viewed: 18 (1 ULiège) First constraints on the magnetic field strength in extra-Galactic stars: FORS2 observations of Of?p stars in the Magellanic CloudsBagnulo, S.; Nazé, Yaël ; Howarth, I. D. et alin Astronomy and Astrophysics (2017), 601(A136), 10Massive O-type stars play a dominant role in our Universe, but many of their properties remain poorly constrained. In the last decade magnetic fields have been detected in all Galactic members of the ... [more ▼]Massive O-type stars play a dominant role in our Universe, but many of their properties remain poorly constrained. In the last decade magnetic fields have been detected in all Galactic members of the distinctive Of?p class, opening the door to a better knowledge of all O-type stars. With the aim of extending the study of magnetic massive stars to nearby galaxies, to better understand the role of metallicity in the formation of their magnetic fields and magnetospheres, and to broaden our knowledge of the role of magnetic fields in massive star evolution, we carried out spectropolarimetry of five extra-Galactic Of?p stars, and of a couple of dozen neighbouring stars. We were able to measure magnetic fields with typical error bars from 0.2 to 1.0 kG, depending on the apparent magnitude and on weather conditions. No magnetic field was firmly detected in any of our measurements, but we were able to estimate upper limits on the field values of our target stars. One of our targets, 2dFS 936, exhibited an unexpected strengthening of emission lines. We confirm the unusual behaviour of BI 57, which exhibits a 787 d period with two photometric peaks and one spectroscopic maximum. The observed strengthening of the emission lines of 2dFS 936, and the lack of detection of a strong magnetic field in a star with such strong emission lines is at odd with expectations. Together with the unusual periodic behaviour of BI 57, it represents a challenge for the current models of Of?p stars. The limited precision that we obtained in our field measurements (in most cases as a consequence of poor weather) has led to field-strength upper limits that are substantially larger than those typically measured in Galactic magnetic O stars. Further higher precision observations and monitoring are clearly required. [less ▲]Detailed reference viewed: 30 (3 ULiège) How unique is Plaskett's star? A search for organized magnetic fields in short period, interacting or post-interaction massive binary systems★Nazé, Yaël ; Neiner, Coralie; Grunhut, Jason et alin Monthly Notices of the Royal Astronomical Society (2017), 467Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have ... [more ▼]Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have occurred in this system, one may wonder about their potential role in generating magnetic fields. Stokes V spectra collected with the low-resolution FORS2 and high-resolution ESPaDOnS and Narval spectropolarimeters were therefore used to search for magnetic fields in 15 interacting or post-interaction massive binaries. No magnetic field was detected in any of them, with 0 G always being within 2σ of the derived values. For 17 out of 25 stars in the systems observed at high resolution, the 90 per cent upper limit on the individual dipolar fields is below the dipolar field strength of Plaskett's secondary; a similar result is found for five out of six systems observed at low resolution. If our sample is considered to form a group of stars sharing similar magnetic properties, a global statistical analysis results in a stringent upper limit of ∼200 G on the dipolar field strength. Moreover, the magnetic incidence rate in the full sample of interacting or post-interaction systems (our targets + Plaskett's star) is compatible with that measured from large surveys, showing that they are not significantly different from the general O-star population. These results suggest that binary interactions play no systematic role in the magnetism of such massive systems. [less ▲]Detailed reference viewed: 25 (2 ULiège) A threshold-based weather model for predicting stripe rust infection in winter wheatEl Jarroudi, Moussa ; Kouadio, Louis; Bock, Clive et alin Plant Disease (2017), 101(693-703), Wheat stripe rust (caused by Puccinia striiformis f. sp. tritici) is a major threat in most wheat growing regions worldwide, which potentially causes substantial yield losses when environmental conditions ... [more ▼]Wheat stripe rust (caused by Puccinia striiformis f. sp. tritici) is a major threat in most wheat growing regions worldwide, which potentially causes substantial yield losses when environmental conditions are favorable. Data from 1999-2015 for three representative wheat-growing sites in Luxembourg were used to develop a threshold-based weather model for predicting wheat stripe rust. First, the range of favorable weather conditions using a Monte Carlo simulation method based on the Dennis model were characterized. Then, the optimum combined favorable weather variables (air temperature, relative humidity, and rainfall) during the most critical infection period (May-June) was identified and was used to develop the model. Uninterrupted hours with such favorable weather conditions over each dekad (i.e., 10-day period) during May-June were also considered when building the model. Results showed that a combination of relative humidity > 92% and 4°C < temperature < 16°C for a minimum of 4 continuous hours, associated with rainfall ≤ 0.1 mm (with the dekad having these conditions for 5-20% of the time), were optimum to the development of a wheat stripe rust epidemic. The model accurately predicted infection events: probabilities of detection were ≥ 0.90 and false alarm ratios were ≤ 0.38 on average, and critical success indexes ranged from 0.63 to 1. The method is potentially applicable to studies of other economically important fungal diseases of other crops or in different geographical locations. If weather forecasts are available, the threshold-based weather model can be integrated into an operational warning system to guide fungicide applications. [less ▲]Detailed reference viewed: 52 (8 ULiège) Peculiar architectures for the WASP-53 and WASP-81 planet-hosting systems★Triaud, Amaury H. M. J.; Neveu-VanMalle, Marion; Lendl, Monika et alin Monthly Notices of the Royal Astronomical Society (2017), 467We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the ... [more ▼]We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the photometric signals were indeed produced by two transiting hot Jupiters. Our observations also show the presence of additional Doppler signals. In addition to short-period hot Jupiters, we find that the WASP-53 and WASP-81 systems also host brown dwarfs, on fairly eccentric orbits with semimajor axes of a few astronomical units. WASP-53c is over 16 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB] and WASP-81c is 57 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB]. The presence of these tight, massive companions restricts theories of how the inner planets were assembled. We propose two alternative interpretations: the formation of the hot Jupiters within the snow line or the late dynamical arrival of the brown dwarfs after disc dispersal. We also attempted to measure the Rossiter-McLaughlin effect for both hot Jupiters. In the case of WASP-81b, we fail to detect a signal. For WASP-53b, we find that the planet is aligned with respect to the stellar spin axis. In addition we explore the prospect of transit-timing variations, and of using Gaia's astrometry to measure the true masses of both brown dwarfs and also their relative inclination with respect to the inner transiting hot Jupiters. [less ▲]Detailed reference viewed: 15 (1 ULiège) The HARPS search for southern extra-solar planets. XXXVI. Eight HARPS multi-planet systems hosting 20 super-Earth and Neptune-mass companionsUdry, S.; Dumusque, X.; Lovis, C. et alin ArXiv e-prints (2017), 1705We present radial-velocity measurement of eight stars observed with the HARPS Echelle spectrograph mounted on the 3.6-m telescope in La Silla (ESO, Chile). Data span more than ten years and highlight the ... [more ▼]We present radial-velocity measurement of eight stars observed with the HARPS Echelle spectrograph mounted on the 3.6-m telescope in La Silla (ESO, Chile). Data span more than ten years and highlight the long-term stability of the instrument. We search for potential planets orbiting HD20003, HD20781, HD21693, HD31527, HD45184, HD51608, HD134060 and HD136352 to increase the number of known planetary systems and thus better constrain exoplanet statistics. After a preliminary phase looking for signals using generalized Lomb-Scargle periodograms, we perform a careful analysis of all signals to separate \emph{bona-fide} planets from spurious signals induced by stellar activity and instrumental systematics. We finally secure the detection of all planets using the efficient MCMC available on the Data and Analysis Center for Exoplanets (DACE web-platform), using model comparison whenever necessary. In total, we report the detection of twenty new super-Earth to Neptune-mass planets, with minimum masses ranging from 2 to 30 M$_{\rm Earth}$, and periods ranging from 3 to 1300 days. By including CORALIE and HARPS measurements of HD20782 to the already published data, we also improve the characterization of the extremely eccentric Jupiter orbiting this host. [less ▲]Detailed reference viewed: 21 (2 ULiège) Gaia Data Release 1. Open cluster astrometry: performance, limitations, and future prospectsGaia Collaboration; van Leeuwen, F.; Vallenari, A. et alin Astronomy and Astrophysics (2017), 601Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and ... [more ▼]Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 positions in 1991.25 as prior information.
Conclusions: The Gaia DR1 provides the means to examine open clusters far beyond their more easily visible cores, and can provide membership assessments based on proper motions and parallaxes. A combined HR diagram shows the same features as observed before using the Hipparcos data, with clearly increased luminosities for older A and F dwarfs. Tables D.1 to D.19 are also available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A19 [less ▲]Detailed reference viewed: 39 (4 ULiège) Study of the plutino object (208996) 2003 AZ84 from stellar occultations: size, shape and topographic featuresDias-Oliveira, A.; Sicardy, B.; Ortiz, J. L. et alin The Astronomical Journal (2017), 154(1), 13We present results derived from four stellar occultations by the plutino object (208996) 2003~AZ$_{84}$, detected at January 8, 2011 (single-chord event), February 3, 2012 (multi-chord), December 2, 2013 ... [more ▼]We present results derived from four stellar occultations by the plutino object (208996) 2003~AZ$_{84}$, detected at January 8, 2011 (single-chord event), February 3, 2012 (multi-chord), December 2, 2013 (single-chord) and November 15, 2014 (multi-chord). Our observations rule out an oblate spheroid solution for 2003~AZ$_{84}$'s shape. Instead, assuming hydrostatic equilibrium, we find that a Jacobi triaxial solution with semi axes $(470 \pm 20) \times (383 \pm 10) \times (245 \pm 8)$~km % axis ratios $b/a= 0.82 \pm 0.05$ and $c/a= 0.52 \pm 0.02$, can better account for all our occultation observations. Combining these dimensions with the rotation period of the body (6.75~h) and the amplitude of its rotation light curve, we derive a density $\rho=0.87 \pm 0.01$~g~cm$^{-3}$ a geometric albedo $p_V= 0.097 \pm 0.009$. A grazing chord observed during the 2014 occultation reveals a topographic feature along 2003~AZ$_{84}$'s limb, that can be interpreted as an abrupt chasm of width $\sim 23$~km and depth $> 8$~km or a smooth depression of width $\sim 80$~km and depth $\sim 13$~km (or an intermediate feature between those two extremes). [less ▲]Detailed reference viewed: 13 (4 ULiège) 3D shape of asteroid (6)~Hebe from VLT/SPHERE imaging: Implications for the origin of ordinary H chondritesMarsset, M.; Carry, B.; Dumas, C. et alin Astronomy and Astrophysics (2017), 604Context. The high-angular-resolution capability of the new-generation ground-based adaptive-optics camera SPHERE at ESO VLT allows us to assess, for the very first time, the cratering record of medium ... [more ▼]Context. The high-angular-resolution capability of the new-generation ground-based adaptive-optics camera SPHERE at ESO VLT allows us to assess, for the very first time, the cratering record of medium-sized (D~100-200 km) asteroids from the ground, opening the prospect of a new era of investigation of the asteroid belt's collisional history. Aims. We investigate here the collisional history of asteroid (6) Hebe and challenge the idea that Hebe may be the parent body of ordinary H chondrites, the most common type of meteorites found on Earth (~34% of the falls). Methods. We observed Hebe with SPHERE as part of the science verification of the instrument. Combined with earlier adaptive-optics images and optical light curves, we model the spin and three-dimensional (3D) shape of Hebe and check the consistency of the derived model against available stellar occultations and thermal measurements. Results. Our 3D shape model fits the images with sub-pixel residuals and the light curves to 0.02 mag. The rotation period (7.274 47 h), spin (343 deg,+47 deg), and volume-equivalent diameter (193 +/- 6km) are consistent with previous determinations and thermophysical modeling. Hebe's inferred density is 3.48 +/- 0.64 g.cm-3 , in agreement with an intact interior based on its H-chondrite composition. Using the 3D shape model to derive the volume of the largest depression (likely impact crater), it appears that the latter is significantly smaller than the total volume of close-by S-type H-chondrite-like asteroid families. Conclusions. Our results imply that (6) Hebe is not the most likely source of H chondrites. Over the coming years, our team will collect similar high-precision shape measurements with VLT/SPHERE for ~40 asteroids covering the main compositional classes, thus providing an unprecedented dataset to investigate the origin and collisional evolution of the asteroid belt. [less ▲]Detailed reference viewed: 10 (3 ULiège) Anesthesia Case of the MonthTutunaru, Alexandru-Cosmin ; Sandersen, Charlotte in Journal of the American Veterinary Medical Association [=JAVMA] (2017), 250(9), 984-987Detailed reference viewed: 48 (3 ULiège) In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical reviewPestieau, Aude ; Evrard, Brigitte in European Journal of Pharmaceutical Sciences (2017), 102For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]Detailed reference viewed: 28 (6 ULiège) Experimental passive flutter suppression using a linear tuned vibration absorberVerstraelen, Edouard ; Habib, Giuseppe ; Kerschen, Gaëtan et alin AIAA Journal (2017), 55(5), 1707-1722The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be ... [more ▼]The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be increased flexibility, which in turn can lead to un- favourable aeroelastic phenomena involving large amplitude oscillations and non- linear effects such as geometric hardening and stall flutter. Vibration mitigation is one of the approaches currently under study for avoiding these phenomena. In the present work, passive vibration mitigation is applied to a nonlinear experimental aeroelastic system by means of a linear tuned vibration absorber. The aeroelastic apparatus is a pitch and flap wing that features a continuously hardening restoring torque in pitch and a linear restoring torque in flap. Extensive analysis of the sys- tem with and without absorber at pre-critical and post-critical airspeeds showed an improvement in flutter speed of around 36%, a suppression of a jump due to stall flutter, and a reduction in LCO amplitude. Mathematical modelling of the exper- imental system is used to demonstrate that optimal flutter delay is achieved when two of the system modes flutter at the same flight condition. Nevertheless, even this optimal absorber quickly loses effectiveness as it is detuned. The wind tunnel mea- surements showed that the tested absorbers were much slower to lose effectiveness than those of the mathematical predictions. [less ▲]Detailed reference viewed: 123 (35 ULiège) Two-qubit entangling gates between distant atomic qubits in a latticeCesa, Alexandre ; Martin, John in Physical Review A (2017), 95Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two ... [more ▼]Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two-qubit conditional gates between nearest-neighbor qubits in the array can be implemented by exploiting the Rydberg blockade mechanism, as was shown by D. Jaksch et al. [Phys. Rev. Lett. 85, 2208 (2000)]. However, the energy shift due to dipole-dipole interactions causing the blockade falls off rapidly with the interatomic distance, and protocols based on direct Rydberg blockade typically fail to operate between atoms separated by more than one lattice site. In this work, we propose an extension of the protocol of Jaksch et al. for controlled-Z and controlled-NOT gates which works in the general case where the qubits are not nearest neighbors in the array. Our proposal relies on the Rydberg excitation hopping along a chain of ancilla noncoding atoms connecting the qubits on which the gate is to be applied. The dependence of the gate fidelity on the number of ancilla atoms, the blockade strength, and the decay rates of the Rydberg states is investigated. A comparison between our implementation of a distant controlled-NOT gate and one based on a sequence of nearest-neighbor two-qubit gates is also provided. [less ▲]Detailed reference viewed: 51 (12 ULiège) La Cour de cassation face à sa propre faute (obs. sous C.C. 2017/22)Bouhon, Frédéric in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), 2017/22Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les ... [more ▼]Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les dommages engendrés par la faute du juge. Il est question du cas particulier où un justiciable demande au juge du fond de condamner l’État belge à réparer un dommage causé par une faute qu’aurait commise la Cour de cassation. Plus précisément, il apporte une réponse – positive – à la question de savoir si cette haute juridiction peut, dans l’hypothèse où un pourvoi est formé contre la décision du juge du fond, intervenir dans une affaire qui concerne une faute qu’elle a prétendument commise, en influençant, le cas échéant, l’interprétation de la notion de faute appliquée à son propre acte. [less ▲]Detailed reference viewed: 26 (4 ULiège) Ultrasonic roll bite measurements in cold rolling: Contact length and strip thicknessCarretta, Yves; Hunter, Andrew; Boman, Romain et alin Proceedings of the Institution of Mechanical Engineers - Part J - Journal of Engineering Tribology (2017)In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip ... [more ▼]In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, online process measurements are usually carried out; such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area. This paper presents a sensor capable of monitoring strip thickness variations as well as roll bite length in situ and in real time. The sensor emits ultrasonic pulses that reflect from the interface between the roll and the strip. Both the time-of-flight of the pulses and the reflection coefficient (the ratio of the amplitude of the reflected signal to that of the incident signal) are recorded. The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under several lubrication conditions. Strip thickness variation and roll-bite length obtained from the experimental data agree well with numerical results computed with a cold rolling model in the mixed lubrication regime. [less ▲]Detailed reference viewed: 46 (4 ULiège) Intergroup variation in robbing and bartering by long-tailed macaques at Uluwatu Temple (Bali, Indonesia)Brotcorne, Fany ; Giraud, Gwennan; Gunst, Noelle et alin Primates : Journal of Primatology (2017)Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the ... [more ▼]Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the macaques appear to use them as tokens, returning them to humans in exchange for food. While extensively studied in captivity, our research is the first to investigate the object/food exchange between humans and primates in a natural setting. During a 4-month study in 2010, we used both focal and event sampling to record 201 RB events in a population of long-tailed macaques (Macaca fascicularis), including four neighboring groups ranging freely around Uluwatu Temple, Bali (Indonesia). In each group, we documented the RB frequency, prevalence and outcome, and tested the underpinning anthropogenic and demographic determinants. In line with the environmental opportunity hypothesis, we found a positive qualitative relation at the group level between time spent in tourist zones and RB frequency or prevalence. For two of the four groups, RB events were significantly more frequent when humans were more present in the environment. We also found qualitative partial support for the male-biased sex ratio hypothesis [i.e., RB was more frequent and prevalent in groups with higher ratios of (sub)adult males], whereas the group density hypothesis was not supported. This preliminary study showed that RB is a spontaneous, customary (in some groups), and enduring population-specific practice characterized by intergroup variation in Balinese macaques. As such, RB is a candidate for a new behavioral tradition in this species. [less ▲]Detailed reference viewed: 32 (9 ULiège) Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotidesDelierneux, Céline ; Donis, Nathalie ; servais, laurence et alin Journal of Thrombosis and Haemostasis (2017), 15(5), 983-997Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment ... [more ▼]Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment. Unexpectedly, a recent study indicates that CpG ODNs activate human platelets via the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptor glycoprotein VI. Objective: To further analyze the mechanisms of CpG ODN-induced platelet activation and identify potential inhibitory strategies. Methods: In vitro analyses were performed on human and mouse platelets, and on cell lines expressing platelet ITAM receptors. CpG ODN platelet activating effects were evaluated in a mouse model of thrombosis. Results: We demonstrated platelet uptake of CpG ODNs, resulting in platelet activation and aggregation. The C-type lectin-like receptor 2 (CLEC-2) expressed in DT40 cells bound CpG ODNs. CpG ODN uptake did not occur in CLEC-2-deficient mouse platelets. Inhibition of human CLEC-2 with a blocking antibody inhibited CpG ODN-induced platelet aggregation. CpG ODNs caused CLEC-2 dimerization, and provoked its internalization. They induced dense granule release before the onset of aggregation. Accordingly, pretreating platelets with apyrase, or inhibiting P2Y12 with cangrelor or clopidogrel prevented CpG ODN platelet activating effect. In vivo, intravenously injected CpG ODN interacted with platelets adhered to mouse injured endothelium, and promoted thrombus growth, which was inhibited by CLEC-2 deficiency or by clopidogrel. Conclusions: CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis and might be targeted to prevent adverse events in patients at risk. [less ▲]Detailed reference viewed: 41 (20 ULiège) Experimental and Numerical Study of Mini-UAV Propeller Performance in Oblique FlowTheys, Bart; Dimitriadis, Grigorios ; Hendrick, Patrick et alin Journal of Aircraft (2017), 54(3), 1076-1084This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow ... [more ▼]This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow. Blade Element Momentum Theory (BEMT), Vortex Lattice Method (VLM) and momentum theory for oblique flow are used to predict propeller performance. For validation, the predictions for a commonly used propeller for VTOL MAVs are compared to a set of wind tunnel experiments. Both BEMT and VLM succeed in predicting correct trends of the forces and moments acting upon the propeller shaft, although accuracy decreases significantly in oblique flow. For the dataset analysed here, combining the available data of the propeller in purely axial flow with momentum theory for oblique flow and applying a correction factor for the wake skew angle results in more accurate performance estimates at all elevation angles. [less ▲]Detailed reference viewed: 82 (14 ULiège) PRTEE et épicondyliteJanssen, Arnaud; Kaux, Jean-François in Kinésithérapie du Sport Information (2017), (2ème trimestre 2017), 4-7Detailed reference viewed: 26 (3 ULiège) Calibration and testing of wide-field UV instrumentsFrey, Harald; Mende, Stephen; Loicq, Jerôme et alin Journal of Geophysical Research. Space Physics (2017), 122As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations ... [more ▼]As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations difficult is the need for working in vacuum substantially extending the required time and effort compared to visible systems. In theory a ray tracing and characterization of each individual component of the optical system (mirrors, windows, and grating) should provide the transmission efficiency of the combined system. However, potentially unknown effects (contamination, misalignment, and measurement errors) can make the final error too large and unacceptable for most applications. Therefore, it is desirable to test and measure the optical properties of the whole system in vacuum and compare the overall response to the response of a calibrated photon detector. A proper comparison then allows the quantification of individual sources of uncertainty and ensures that the whole instrument performance is within acceptable tolerances or pinpoints which parts fail to meet requirements. Based on the experience with the IMAGE Spectrographic Imager, the Wide-band Imaging Camera, and the ICON Far Ultraviolet instruments, we discuss the steps and procedures for the proper radiometric sensitivity and passband calibration, spot size, imaging distortions, flatfield, and field of view determination. [less ▲]Detailed reference viewed: 28 (4 ULiège) Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytesDemine, Stéphane; Tejerina, Silvia; Bihin, Benoît et alin Journal of Cellular Physiology (2017)Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet ... [more ▼]Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet-associated proteins as well as lipolytic enzymes have been identified. Increasing energy expenditure by inducing a mild uncoupling of mitochondria in adipocytes might represent a putative interesting anti-obesity strategy as it reduces the adipose tissue triacylglycerol content (limiting alterations caused by cell hypertrophy) by stimulating lipolysis through yet unknown mechanisms, limiting the adverse effects of adipocyte hypertrophy. Herein, the molecular mechanisms involved in lipolysis induced by a mild uncoupling of mitochondria in white 3T3-L1 adipocytes were characterized. Mitochondrial uncoupling-induced lipolysis was found to be independent from canonical pathways that involve lipolytic enzymes such as HSL and ATGL. Finally, enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles. This new mechanism of triacylglycerol breakdown in adipocytes exposed to mild uncoupling provides new insights on the biology of adipocytes dealing with mitochondria forced to dissipate energy. [less ▲]Detailed reference viewed: 24 (2 ULiège) Unravelling fluvial deposition and pedogenesis in ephemeral stream deposits in the vicinity of the prehistoric rock shelter of Ifri n'Ammar (NE Morocco) during the last 100 kaBartz, Melanie; Rixhon; Kehl, Martin et alin Catena (2017), 152Detailed reference viewed: 38 (7 ULiège) Première consultation ambulatoire du nouveau-néRIGO, Vincent ; PIELTAIN, Catherine ; Schoffeniels, Colombe et alin Revue Médicale de Liège (2017), 72(5), 253-259The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate ... [more ▼]The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate feedings are checked. Sudden infant death syndrome prevention and security advices are reminded. Realisation of both neonatal dried blood screen and hearing test is confirmed, as well as planning of specific follow-up appointments. The physical exam will focus on red flags for diseases or malformations with a delayed presentation. [less ▲]Detailed reference viewed: 53 (8 ULiège) Effect of Multicolumn Lead Spinal Cord Stimulation on Low Back Pain in Failed Back Surgery Patients: A Three-Year Follow-UpRemacle, Thibault ; BONHOMME, Vincent ; Renwart, Henri-Jean et alin Neuromodulation (2017)OBJECTIVES:Spinal cord stimulation (SCS) remains poorly efficient at reducing back pain in failed back surgery syndrome (FBSS) patients. We aimed at determining whether a new multicolumn lead SCS ... [more ▼]OBJECTIVES:Spinal cord stimulation (SCS) remains poorly efficient at reducing back pain in failed back surgery syndrome (FBSS) patients. We aimed at determining whether a new multicolumn lead SCS technique was efficient at durably reducing their leg (LP) and back (BP) pain. MATERIALS AND METHODS:Sixty-two consecutive refractory FBSS patients received multicolumn SCS. Visual analogue scale (VAS) self-evaluation of BP, LP, and limitation of daily activity (LAD) were recorded preoperatively and at 2, 6, 12, 24, and 36 months after surgery. Quality of sleep and use of concomitant medications were also recorded. RESULTS:Complete datasets were obtained in 29 patients. BP (median VAS [25-75 centiles]) significantly decreased from 9 (8.5-10) preoperatively, to 3 (3-4) at short-term follow-up (2 months), and rose up to 5 (4-5) at 36 months. LP evolved from 7 (6-8) preoperatively, to 2.5 (2-3) at short-term follow-up, and 3 (2-3) at 36 months. Correspondingly, LAD VAS was 8 (8-9) preoperatively, and decreased to stable values of 3 (3-4) during the follow-up period. Quality of sleep also improved, with 72% of patients reporting poor sleep preoperatively to 0-7% in the follow-up period until 36 months. The percentages of patients regularly taking analgesic and/or co-analgesic medications decreased from 100% preoperatively to 8, 4, 12, 19, and 19%. CONCLUSION:Multicolumn lead SCS in FBSS patients significantly improve BP, LP, quality of life, and medication consumption for at least 36 months. A classical placebo effect cannot account for long-term improvements of such magnitude. [less ▲]Detailed reference viewed: 28 (1 ULiège) Powers, abilities and skills in early modern philosophyBoccaccini, Federico ; Marmodoro, Annain British Journal for the History of Philosophy (2017), 25(3), 1-8Detailed reference viewed: 30 (5 ULiège) Discovery and pharmacological characterization of succinate receptor (SUCNR1/GPR91) agonistsGeubelle, Pierre ; Gilissen, Julie; Dilly, Sebastien et alin British Journal of Pharmacology (2017), 174(9), 796-808Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho ... [more ▼]Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho)physiological processes, the function of SUCNR1 has remained elusive because no pharmacological tools were available. We report on the discovery of the first family of synthetic potent agonists. Experimental Approach We screened a library of succinate analogues and analysed their activity on SUCNR1. In addition, we modelled a pharmacophore and a binding site for the receptor. New agonists were identified based on the information provided by these two approaches. Their activity was studied in various bioassays, including measurement of cAMP levels, [Ca2+]i mobilisation, TGF-α shedding and recruitment of arrestin 3. The in vivo impact of SUCNR1 activation by these new agonists was evaluated on rat blood pressure. Key Results We identified cis-epoxysuccinic acid and cis-1,2-cyclopropanedicarboxylic acid as agonists with an efficacy similar to the one of succinic acid. Interestingly, cis-epoxysuccinic acid was characterized by a 10 to 20 fold higher potency than succinate on the receptor. For example, cis-epoxysuccinic acid reduced cAMP levels with a pEC50 = 5.57 ± 0.02 (EC50 = 2.7 μM) as compared to succinate pEC50 = 4.54 ± 0.08 (EC50 = 29 μM). The rank order of potency of the three agonists was the same in all bioassays tested. In vivo, cis-epoxysuccinic and cis-1,2-cyclopropanedicarboxylic acid increased rat blood pressure to the same extent as succinate did. Conclusions and Implications We provide new agonist tools for SUCNR1 that should facilitate further research on this understudied receptor. [less ▲]Detailed reference viewed: 52 (13 ULiège) Merci à vous!RADERMECKER, Régis in Revue de l'Association Belge du Diabète (2017), 60(3), Detailed reference viewed: 44 (2 ULiège) Modeling the strain localization around an underground gallery with a hydro-mechanical double scale model; effect of anisotropyvan den Eijnden, AP; Bésuelle, Pierre; Collin, Frédéric et alin Computers and Geotechnics (2017), 85Detailed reference viewed: 64 (3 ULiège)