References of "Article"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailFibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women
Runhaar, Jos; Sanchez, Christelle ULg; Taralla, Sébastien et al

in Osteoarthritis Cartilage (2016), 24(4), 672-678

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg ... [more ▼]

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 +/- 3.2 years and mean BMI of 31.7 +/- 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >/=1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade >/=2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic pain at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. [less ▲]

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailClinically Relevant Optical Properties of Bifocal, Trifocal, and Extended Depth of Focus Intraocular Lenses
Gatinel, Damien; Loicq, Jerôme ULg

in Journal of Refractive Surgery (2016), 32(4), 273-280

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ... [more ▼]

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ZMB00 (bifocal; Abbott Medical Optics, Abbott Park, IL), TECNIS Symfony ZXR00 (extended depth of focus; Abbott Medical Optics), and FineVision GFree hydrophobic (trifocal; PhysIOL, Liège, Belgium). Their surface topography was analyzed by optical microscopy. Modulation transfer function (MTF) and spherical aberrations were determined on optical bench for variable pupil apertures and with two cornea models (0 μm and +0.28 μm). United States Air Force target imaging was analyzed for different focal points (near, intermediate, and far). Point spread function (PSF) and halos were quantified and compared. RESULTS: The three lenses presented step-like optic topography. For a pupil size of 3 mm or greater, clearly distinctive MTF peaks were observed for all lenses: two peaks for the extended depth of focus and bifocal lenses with +1.75 and +4.00 diopters (D) addition, respectively, and three peaks for the trifocal lens with +1.75 and +3.50 addition for intermediate and near vision, respectively. The extended depth of focus and bifocal lens had slightly higher MTF at best focus with the +0.28 μm cornea model than with the 0 μm model, whereas the trifocal lens was likely to be more independent of the corneal spherical aberrations.CONCLUSIONS: It appears that the three lenses rely on light diffraction for their optical performance, presenting halos with comparable intensities. For small pupil apertures (< 3 mm), the MTF peaks for the far and intermediate focal distances of the trifocal and extended depth of focus lenses overlap, but the trifocal lens presented an additional MTF peak for the near focal points. [less ▲]

Detailed reference viewed: 31 (8 ULg)
Full Text
Peer Reviewed
See detailLe hate speech et la liberté d'expression dans la jurisprudence américaine sous l'angle de la philosophie du langage
Thirion, Nicolas ULg; Vandenbulke, Antoine ULg

in Auteurs & Media (2016)

Analysis of landmark US Supreme Court cases on hate speech evaluated in terms of philosophy of language, particularly through the works of J.L. Austin and Judith Butler.

Detailed reference viewed: 37 (13 ULg)
Full Text
Peer Reviewed
See detailHistopathological effects of Aspergillus clavatus (Ascomycota: Trichocomaceae) on larvae of the southern house mosquito, Culex quinquefasciatus (Diptera: Culicidae)
Bawin, Thomas ULg; Seye, Fawrou; Boukraa, Slimane ULg et al

in Fungal Biology (2016), 120(4), 489-499

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal ... [more ▼]

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal activity was investigated regarding histological damages on Culex quinquefasciatus larvae exposed to A. clavatus spores. Multiple concentration assays using spore suspensions (0.5 x 10^8 to 2.5 x 10^8 spores/ml) revealed 17.0% to 74.3% corrected mortalities after 48 h exposure. Heat-deactivated spores induced a lower mortality compared to non-heated spores suggesting that insecticidal effects are actively exerted. Spore-treated and untreated larvae were prepared for light microscopy as well as for scanning and transmission electron microscopy. Spores failed to adhere to the external body surface (except the mouth parts) of these aquatic immature stages but progressively filled the digestive tract where their metabolism seemed to activate. In parallel, the internal tissues of the larvae, i.e. the midgut wall, the skeletal muscles, and the cuticle-secreting epidermis, were progressively destroyed between 8 and 24 h of exposure. These observations suggest that toxins secreted by active germinating spores of A. clavatus in the digestive tract altered the larval tissues, leading to their necrosis and causing larval death. Fungal proliferation and sporulation then occurred during a saprophytic phase. A. clavatus enzymes or toxins responsible for these pathogenic effects need to be identified in further studies before any use of this fungus in mosquito control. [less ▲]

Detailed reference viewed: 68 (20 ULg)
Full Text
Peer Reviewed
See detailExercise-triggered chest pain as an isolated symptom of myocarditis in children
Tshimanga, Prisca; Daron, Benoît; FARHAT, Nesrine ULg et al

in Clinics and Practice (2016)

Detailed reference viewed: 12 (8 ULg)
Full Text
Peer Reviewed
See detailBrentano or Husserl? Intentionality, Consciousness, and Self-consciousness in Contemporary Phenomenology of Mind
Boccaccini, Federico ULg

in Archivio di Filosofia (2016), LXXXIII(3), 189-202

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detailLagrangian and arbitrary Lagrangian Eulerian simulations of complex roll-forming processes
Crutzen, Yanick ULg; Boman, Romain ULg; Papeleux, Luc ULg et al

in Comptes Rendus Mécanique (2016), 344(4-5), 251-266

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ... [more ▼]

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ALE formalism can compute the hopefully stationary state for the entire mill length with definitely effortless set-up tasks thanks to a nearly-stationary mesh. In this paper, advantages of ALE and Lagrangian formalisms are extensively discussed for simulating such continuous-type processes. Through a highly complex industrial application, the ease of use of ALE modelling is illustrated with the in-house code METAFOR. ALE and Lagrangian results are in good agreement with each other. [less ▲]

Detailed reference viewed: 23 (11 ULg)
Full Text
Peer Reviewed
See detailMicrowave-assisted extraction of pectin from unutilized pumpkin biomass
Košťálová, Zuzana; Aguedo, Mario ULg; Hromádkováa, Zdenka

in Chemical Engineering and Processing: Process Intensification (2016), 102

Microwave-assisted extraction was employed to extract polysaccharides from pumpkin biomass and compared to the usual extraction by conventional heating. The effect of microwave heating time, liquid/solid ... [more ▼]

Microwave-assisted extraction was employed to extract polysaccharides from pumpkin biomass and compared to the usual extraction by conventional heating. The effect of microwave heating time, liquid/solid (L/S) ratio and extraction temperature on the yield and molecular mass of extracted pectin from the seeded oil pumpkin biomass was investigated. Heating times ranged from 2 to 10 min, L/S ratio from 30/1 to 50/1 and temperature from 80 to 120 °C. The response surface methodology was used to optimize the effects of processing parameters to isolate pectin with medium molecular weight and with the highest yield. The retained conditions were as follows: liquid/solid ratio 50/1, microwave heating time of 10 min and a temperature of 102.2 °C. Among the studied factors, the liquid/solid ratio had the greatest influence on yield and molecular mass, respectively. Application of microwave heating in the extraction of pumpkin biomass gave a pectin with medium Mw and dramatically reduced extraction time in comparison to traditional hot acid extraction. Microwave is an excellent tool for extraction and modification of polysaccharides in one step. [less ▲]

Detailed reference viewed: 27 (3 ULg)
Full Text
See detailInsertion professionnelle et parcours enseignants : mise en perspective
Simons, Germain ULg

in Didactiques en pratique (2016), (2),

Detailed reference viewed: 46 (9 ULg)
Full Text
Peer Reviewed
See detailUne école belge de l’anticipation ?
Stienon, Valérie ULg

in Textyles : Revue des Lettres Belges de Langue Française (2016), 48

Prolifique dans les littératures de l'imaginaire, la Belgique présente pourtant une inconnue s'agissant du récit d'anticipation. Il suffit pour en prendre la mesure de comparer les situations respectives ... [more ▼]

Prolifique dans les littératures de l'imaginaire, la Belgique présente pourtant une inconnue s'agissant du récit d'anticipation. Il suffit pour en prendre la mesure de comparer les situations respectives de ces deux « genres » réputés voisins que sont la science-fiction et le fantastique. Celui-ci a été érigé en emblème des terres du syncrétisme et de l'étrange, tandis que celle-là a souffert d'expressions isolées et de dénis compliquant sa réception. La situation de l'anticipation est plus complexe encore : souvent rattachée à la science-fiction, dont elle constituerait une étape archaïque ou protohistorique, elle ne se confond pas tout à fait avec elle. Ne se définissant pas exclusivement par les thématiques scientifiques ou extraterrestres, ni même par la seule dimension futuriste, l'anticipation se donne pour objet une exploration imaginaire des mondes possibles. Cette exploration s'est manifestée plus d'une fois avec succès dans l'histoire des lettres belges, des fictions de Rosny aîné (Les Xipéhuz, La Force mystérieuse, Les Navigateurs de l'infini) aux mondes parallèles créés par François Schuiten et Benoît Peeters, des aventures spatiales de Bob Morane aux technosciences de Gilbert Hottois. Mais quel dénominateur commun peut-on trouver à ce corpus disparate ? Et comment faire l'archéologie d'une production qui a trouvé des expressions variées et originales malgré une généricité hybride et l'absence de représentant majeur ? [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailVIGNETTE DIAGNOSTIQUE DE L'ETUDIANT. LogBook Numérique : Un carnet de bord réflexif comme outil d'apprentissage en contexte de stage.
Scantamburlo, Gabrielle ULg; Vierset, Viviane; Bonnet, Pierre ULg et al

in Revue Médicale de Liège (2016), 71(4), 210-215

Un LogBook (ou journal de bord) est un outil d’apprentissage et d’accompagnement où sont répertoriées des situations cliniques vécues lors d’un stage. Il joue un rôle essentiel dans la maîtrise des ... [more ▼]

Un LogBook (ou journal de bord) est un outil d’apprentissage et d’accompagnement où sont répertoriées des situations cliniques vécues lors d’un stage. Il joue un rôle essentiel dans la maîtrise des compétences cliniques. Au Centre Hospitalier Universitaire de Liège, nous avons développé un LogBook numérique pour renforcer le guidage des étudiants et favoriser une réflexion vers l’autonomisation. Il apporte des repères utiles aux enseignants cliniciens et aux étudiants. Il est aussi utilisé comme outil de co-évaluation. Ce LogBook a été conçu pour le stage en psychiatrie. Cependant, sa particularité est de pouvoir être adapté à tous les contextes de stage, dans toutes les disciplines, en vue de favoriser une harmonisation cohérente du parcours clinique de l’étudiant, en lien avec les impératifs du cursus donnés par l’Europe. [less ▲]

Detailed reference viewed: 52 (12 ULg)
Full Text
Peer Reviewed
See detailAdaptation transculturelle et validation des questionnaires VISA-P et VISA-A en français
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Science & Sports (2016), 31(2), 65-72

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A ... [more ▼]

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A), English questionnaires developed respectively to assess the severity of patellar and calcaneal tendinopathies. The purpose of our study was to validate a French version of these questionnaires. Materials and methods The French translation and intercultural adaptation of the VISA-P and the VISA-A are made according to international recommendations. For these adaptations, 92 (VISA-P) and 116 (VISA-A) subjects were recruited and divided into 3 groups (pathological, asymptotic and sporting risk), in order to test these psychometric properties. All these subjects also had to answer to the MOS SF-36 for the validity of construct. Results The mean VISA-PF scores were 99 for the healthy people, 53 for patients with patellar tendinopathy and 86 for the athletes. The VISA-PF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.9 (Cronbach's alpha). The VISA-PF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. The mean VISA-AF scores were 99 in the healthy group, 59 in the pathological group, and 94 in the group of athletes. The VISA-AF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.92 (Cronbach's alpha). The VISA-AF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. No floor and ceiling effects were detected during the evaluation of the two questionnaires. Conclusion The French versions of the VISA-P and VISA-A questionnaires are therefore French comprehensible adaptation, reliable and adapted to French-speaking patients suffering from patellar or calcaneal tendinopathies. [less ▲]

Detailed reference viewed: 60 (10 ULg)
Full Text
Peer Reviewed
See detailLe travailleur à temps partiel et la présomption de travail à temps plein
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (14), 654-655

L'article oppose la présomption de travail à temps plein énoncée par l’article 171 de la loi-programme du 22 décembre 1989, qui est étrangère aux relations entre l’employeur et le travailleur, à la ... [more ▼]

L'article oppose la présomption de travail à temps plein énoncée par l’article 171 de la loi-programme du 22 décembre 1989, qui est étrangère aux relations entre l’employeur et le travailleur, à la sanction inscrite dans l'article 11bis de la loi relative aux contrats de travail. Le travailleur ne peut alléguer la présomption pour obtenir le paiement d’arriérés de salaire ou d’une indemnité compensatoire de préavis calculés sur la base d’une rémunération à temps plein. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailSelenium in Cattle: A Review
Mehdi, Youcef ULg; Dufrasne, Isabelle ULg

in Molecules (2016), 21(4), 545

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include ... [more ▼]

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include the participation in the antioxidant defense the cattle farms. The nutritional requirements of Se in cattle are estimated at 100 μg/kg DM (dry matter) for beef cattle and at 300 μg/kg DM for dairy cows. The rations high in fermentable carbohydrates, nitrates, sulfates, calcium or hydrogen cyanide negatively influence the organism’s use of the selenium contained in the diet. The Se supplementation may reduce the incidence of metritis and ovarian cysts during the postpartum period. The increase in fertility when adding Se is attributed to the reduction of the embryonic death during the first month of gestation. A use of organic Se in feed would provide a better transfer of Se in calves relative to mineral Se supplementation. The addition of Se yeasts in the foodstuffs of cows significantly increases the Se content and the percentage of polyunsaturated fatty acids (PUFA) in milk compared to the addition of sodium selenite. The enzyme 5-iodothyronine deiodinase is a seleno-dependent selenoprotein. It is one of the last proteins to be affected in the event of Se deficiency. This delay in response could explain the fact that several studies did not show the effect of Se supplementation on growth and weight gain of calves. Enrichment of Se in the diet did not significantly affect the slaughter weight and carcass yield of bulls. The impact and results of Se supplementation in cattle depend on physiological stage, Se status of animals, type and content of Se and types of Se administration. Further studies in Se supplementation should investigate the speciation of Se in food and yeasts, as well as understanding their metabolism and absorption. This constitute a path to exploit in order to explain certain different effects of Se. [less ▲]

Detailed reference viewed: 83 (9 ULg)
Full Text
Peer Reviewed
See detailInfluence of a liquid nutritional supplement on water intake in experimental Beagle dogs
Rotat, Christelle; Lhoest, Estelle; Rauw, Anaelle ULg et al

in Open Journal of Veterinary Medicine (2016), 6

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over ... [more ▼]

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over design in 8 experimental healthy Beagle dogs (4 males and 4 females, aged 9.3 years). The supplement (87 percent water, 2.7 percent protein, 2.6 percent fat, 0.4 percent crude fiber) was added to water and tested at 2 incorporation rates (50 or 70 ml/day/dog—D50 or D70) versus the control placebo (CO-water only). The dogs were kept in a controlled environment; water intakes and urine output were measured. Individual water intakes were characterised by large variations. Mean water intake increased significantly by 28 percent in dogs receiving the liquid nutritional supplement, in both genders, irrespectively of the dosage. Urine output was also increased, by 55 percent. Faeces scores remained unchanged. It was concluded that the liquid supplement increased water intake and urine output in a safe way, without increasing dramatically the daily dietary sodium chloride intake. The recommended dosage of the manufacturer—50 ml/day for dogs weighing 10 - 20 kg BW is efficient. Increasing the dosage had no advantage, nor adverse effects. Increased water intake and urine output is of interest for dogs suffering from urolithiasis. [less ▲]

Detailed reference viewed: 34 (3 ULg)
Full Text
Peer Reviewed
See detailLes kystes ovariens chez le cobaye
Gillet, Aline; Deflers, Hélène ULg; Marlier, Didier ULg

in Revue de Médecine Vétérinaire (2016), 167(3-4), 51-58

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailQuelle est l’efficacité de soins collaboratifs et intégrés pour des patients en situation de multimorbidité physique et mentale en ambulatoire ?
Belche, Jean ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 58-63

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la ... [more ▼]

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la multimorbidité, définie comme la présence d’au moins 2 maladies chroniques), augmente substantiellement avec l’âge (≥ 65 ans) mais qu’en nombre absolu de patients, elle touche plus de patients plus jeunes (plus de 50% en dessous de 65 ans). Près d’un tiers de ces patients multimorbides souffre de problèmes de santé mentale (dépression, troubles psychotiques, etc.), dont la gravité augmente avec le nombre de comorbidités et le statut socio-économique. L’étude analysée ici fait l’hypothèse d’un bénéfice d’un modèle de soins collaboratif et intégré en première ligne de soins sur la dépression et la gestion de la maladie chronique par le patient, tout en veillant à sélectionner une population représentative du constat démographique actuel de multimorbidité. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailRELMs in the Realm of Helminths
Horsnell, William G. C.; Dewals, Benjamin G ULg

in Trends in parasitology (2016)

Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMalpha over RELMbeta in host immunity to Nippostrongylus ... [more ▼]

Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMalpha over RELMbeta in host immunity to Nippostrongylus brasiliensis using a double knockout system. The study highlighted how important and yet divergent the contributions of these proteins are in the control of helminth infections. [less ▲]

Detailed reference viewed: 24 (3 ULg)
Full Text
Peer Reviewed
See detailLes juristes belges et la réhabilitation du droit à la guerre du Traité de Versailles au ‘Mouvement de Monaco’ de 1933-1938
Genin, Vincent ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), 2016/1(Soixante et unième année), 155-188

Depuis la Charte des Nations Unies de 1945, l'interdiction du "recours à la force" est consacré comme règle de droit international applicable aux Etats. Toutefois, durant l'entre-deux-guerres, surtout de ... [more ▼]

Depuis la Charte des Nations Unies de 1945, l'interdiction du "recours à la force" est consacré comme règle de droit international applicable aux Etats. Toutefois, durant l'entre-deux-guerres, surtout de 1933 à 1938, la réhabilitation d'un droit à la guerre, jugée plus pragmatique par certains juristes que sa mise "hors-la-loi" par le Pacte Briand-Kellogg de 1929, connaît quelque succès. En réaction à ce qu'ils estiment être les "failles" des Pactes de la SDN et de Paris, médecins-militaires et juristes, surtout belges et français, en vue d'"humaniser la guerre" pour, selon eux, la rendre plus rare, forment un éphémère courant, oublié et devenu anachronique : le "Mouvement de Monaco". Tel est l'objet de notre étude. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
See detailAnticipation et mondes parallèles. Entretien avec Benoît Peeters et François Schuiten
Stienon, Valérie ULg

in Textyles : Revue des Lettres Belges de Langue Française (2016), 48

Benoît Peeters et François Schuiten ont aimablement accepté l’invitation de l’entretien, qui a eu lieu le 12 janvier 2015 au café Le Wilson en face du Palais de Chaillot où se tient l’exposition Revoir ... [more ▼]

Benoît Peeters et François Schuiten ont aimablement accepté l’invitation de l’entretien, qui a eu lieu le 12 janvier 2015 au café Le Wilson en face du Palais de Chaillot où se tient l’exposition Revoir Paris. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailLa multimorbidité : le médecin généraliste et les systèmes de santé mis au défi
Belche, Jean ULg; Crismer, André ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 55-57

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la ... [more ▼]

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la multimorbidité, chez un même patient. La manière dont sont structurés la production scientifique et les systèmes de santé, dont le paradigme dominant est la prise en charge de patients avec une seule morbidité, complique la prise en charge adéquate de cette population (1). Søndergaard a dès lors exploré les difficultés que rencontre le médecin généraliste (MG) face aux patients en situation de multimorbidité au travers d’ateliers auxquels ont participé près de 180 MG et chercheurs scandinaves. [less ▲]

Detailed reference viewed: 22 (2 ULg)
Full Text
Peer Reviewed
See detailPregnancy outcome following frozen embryo transfer after artificial cycle or treatment by clomiphene citrate.
JOUAN, Caroline ULg; EMONARD, Violaine ULg; RUGGERI, Philippe ULg et al

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (2016), 29

The optimal method to prepare endometrium before frozen embryo transfer (FET) is not yet established. We retrospectively studied 4496 FET and detailed pregnancy and miscarriage rates in three groups of ... [more ▼]

The optimal method to prepare endometrium before frozen embryo transfer (FET) is not yet established. We retrospectively studied 4496 FET and detailed pregnancy and miscarriage rates in three groups of patients according to the endometrium preparation they have followed before their successive FET: clomifene citrate (CC, group 1), artificial cycle (AC, group 2) or switch between CC and AC (group 3). The overall pregnancy rates per transfer were 24.3, 20.8 and 17.3% while the miscarriage rates reached 23.2, 29.8 and 42.5%, respectively. Group 1 experienced the highest ongoing pregnancy rate (18.6%), the lowest being observed in group 3 (10.0%, p50.001). Here we propose several alternatives to improve our AC protocol (group 2) that seemed less effective than CC (group 1) and we consider the use of a gonadotrophinstimulated treatment for patients with the lowest reproductive outcomes (group 3). [less ▲]

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailDimensioning IRGA gas sampling systems: laboratory and field experiments
Aubinet, Marc ULg; Joly, Lilian; Loustau, Denis et al

in Atmospheric Measurement Techniques (2016), 9

Both laboratory and field experiments were carried out in order to define suitable configuration ranges for the gas sampling systems (GSSs) of infrared gas analyzers (IRGAs) used in eddy covariance ... [more ▼]

Both laboratory and field experiments were carried out in order to define suitable configuration ranges for the gas sampling systems (GSSs) of infrared gas analyzers (IRGAs) used in eddy covariance measurements. In the laboratory, an original dynamic calibration bench was developed in order to test the frequency attenuation and pressure drop generated by filters. In the field, three IRGAs of the same type equipped with different filters or different rain caps were installed and run and the real frequency response of the complete setup was tested. The main results are as follows. – Filters may have a strong impact on the pressure drop in the GSS and this impact increases with flow rate. – Conversely, no impact of the tested filters on cut-off frequency was found, GSSs with and without filters presenting similar cut-off frequencies. – The main limiting factor of cut-off frequency in the field was found to be the rain cap design. In addition, the impact of this design on pressure drop was also found to be noteworthy. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailAbout Quaternary prevention in Public health ; comment on Dr Jong-Myon Bae paper
Jamoulle, Marc ULg

in Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi (2016), 49(2), 139-140

The recent paper of Dr Jong-Myon Bae about Quaternary Prevention and Public Health in your journal has attracted my interest. The spread of this concept is beyond all expectation and I am quite happy it ... [more ▼]

The recent paper of Dr Jong-Myon Bae about Quaternary Prevention and Public Health in your journal has attracted my interest. The spread of this concept is beyond all expectation and I am quite happy it contributes to the analytic thinking of complexity of health care. The particular application of the quaternary prevention (P4) concept is absolutely brilliant. Nevertheless I would propose some slight modifications to the table 1 edited by the author which I have taken the liberty to reproduce here with the due authorization of Dr Bae and after several mail exchanges with him. [less ▲]

Detailed reference viewed: 242 (7 ULg)
Full Text
Peer Reviewed
See detailCharacterization of monovarietal virgin olive oils from introduced cultivars in eastern Morocco
Mansouri, Farid ULg; Benmoumen, A.; Richard, Gaetan ULg et al

in Rivista Italiana Sostanze Grasse (2016), 93

The aim of this study was to characterize monovarietal virgin olive oils (VOOs) of new high-density planting system of three European cultivars (Arbequina, Arbosana and Koroneiki), recently introduced in ... [more ▼]

The aim of this study was to characterize monovarietal virgin olive oils (VOOs) of new high-density planting system of three European cultivars (Arbequina, Arbosana and Koroneiki), recently introduced in eastern Morocco. VOOs’ characterization has been carried out by analyzing several parameters, such as quality indexes, fatty acid contents, minor components, and olive oils’ oxidative stability index (OSI). In this study, we have also conducted a comparison between these monovarietal VOOs and olive oils of autochthones cultivar Picholine marocaine. Significant differences between the analyzed VOOs were highlighted. Koroneiki’s VOO had a high phenols content (493.66 mg/kg) and, consequently, the best oxidative stability (94.83 h); Arbrosana’s VOO was distinguished by its abundance of α-tocopherol (460.07 mg/kg) and by an intermediate OSI (64.83 h). In addition, results showed, firstly, that in all the analyzed oils decarboxymethyl ligstroside aglycone and decarboxymethyl oleuropein aglycone were the main phenolic compounds, and, secondly, that VOOs of Koroneiki and Arbosana seem to have similar profiles, with a high content of natural antioxidants and a high oleic/linoleic ratio, thus boasting a better shelf life. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailDiurnal cycle and multi-decadal trend of formaldehyde in the remote atmosphere near 46° N
Franco, Bruno ULg; Marais, Eloise A.; Bovy, Benoît ULg et al

in Atmospheric Chemistry and Physics (2016), 16

Only very few long-term records of formaldehyde (HCHO) exist that are suitable for trend analysis. Furthermore, many uncertainties remain as to its diurnal cycle, representing a large short-term ... [more ▼]

Only very few long-term records of formaldehyde (HCHO) exist that are suitable for trend analysis. Furthermore, many uncertainties remain as to its diurnal cycle, representing a large short-term variability superimposed on seasonal and inter-annual variations that should be accounted for when comparing ground-based observations to e.g., model results. In this study, we derive a multi-decadal time series (January 1988 – June 2015) of HCHO total columns from ground-based high-resolution Fourier transform infrared (FTIR) solar spectra recorded at the high-altitude station of Jungfraujoch (Swiss Alps, 46.5° N, 8.0° E, 3580 m a.s.l.), allowing for the characterization of the mid-latitudinal atmosphere for background conditions. First we investigate the HCHO diurnal variation, peaking around noontime and mainly driven by the intra-day insolation modulation and methane (CH4) oxidation. We also characterize quantitatively the diurnal cycles by adjusting a parametric model to the observations, which links the daytime to the HCHO columns according to the monthly intra-day regimes. It is then employed to scale all the individual FTIR measurements on a given daytime in order to remove the effect of the intra-day modulation for improving the trend determination and the comparison with HCHO columns simulated by the state-of-the-art chemical transport model GEOS-Chem v9-02. Such a parametric model will be useful to scale the Jungfraujoch HCHO columns on satellite overpass times in the framework of future calibration/validation efforts of space borne sensors. GEOS-Chem sensitivity tests suggest then that the seasonal and inter-annual HCHO column variations above Jungfraujoch are predominantly led by the atmospheric CH4 oxidation, with a maximum contribution of 25 % from the anthropogenic non-methane volatile organic compound precursors during wintertime. Finally, trend analysis of the so-scaled 27-year FTIR time series reveals a long-term evolution of the HCHO columns in the remote troposphere to be related with the atmospheric CH4 fluctuations and the short-term OH variability: +2.9 %/yr between 1988 and 1995, -3.7 %/yr over 1996-2002 and +0.8/% yr from 2003 onwards. [less ▲]

Detailed reference viewed: 62 (25 ULg)
Full Text
Peer Reviewed
See detailImpacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment
Leroi, Natacha ULg; LALLEMAND, François ULg; COUCKE, Philippe ULg et al

in Frontiers in Pharmacology (2016), 7

During the last decade, the initial cancer cell-centered view of tumors has greatly evolved to an integrated vision of tumor biology taking into account the key contribution of the TME. Obviously, the ... [more ▼]

During the last decade, the initial cancer cell-centered view of tumors has greatly evolved to an integrated vision of tumor biology taking into account the key contribution of the TME. Obviously, the different compartments of TME are closely related and contribute not only to tumor progression, but also to its response to treatments. Importantly, the TME evolves over time during the different steps of cancer development and is also affected by different therapeutic modalities. Although, improvements have been achieved regarding RT delivery to the primary tumor, ionizing radiation also target nontumor cells that influence tumor growth and metastatic dissemination. Different approaches have been proposed to overcome the radioresistance of cancer cells. The TME-mediated radioresistance is now the object of researches, which has been elegantly reviewed recently by Barker et al. (2015) and severalarticles pointed out the importance of treatments that modify the TME and likely radiosensitize tumor (Ansiaux et al., 2005; Crokart et al., 2005b; Frérart et al., 2008). However, the impact of anti-cancer treatments on the TME and consequently on the tumor phenotype, response to treatment and metastases, is often neglected. Here we pointed out the impact of RT on the TME. Recent findings emphasize the interest to optimize RT (i.e., dose per fraction) and timing of surgery (Leroi et al., 2015; Surace et al., 2015) in order to prevent metastatic spreading. The future challenge in RT will be to define the most appropriate combinations between RT, and other therapeutic modalities with the optimal sequence and timing of treatments. In this context, investigation of the TME-related acquired resistance will be essential and will provide important innovative data. [less ▲]

Detailed reference viewed: 42 (10 ULg)
Full Text
Peer Reviewed
See detailInfluence of extraction conditions on characteristics of microbial polysaccharide kefiran isolated from kefir grains biomass
Pop Rodica, Carmen; Salanţă, Liana; M. Rotar, Ancuţa et al

in Journal of Food and Nutrition Research (2016)

Kefiran is a water-soluble polysaccharide, which can be isolated from kefir grains biomass. Rheological behaviour and physico-chemical characteristics of kefiran solutions were influenced by the ... [more ▼]

Kefiran is a water-soluble polysaccharide, which can be isolated from kefir grains biomass. Rheological behaviour and physico-chemical characteristics of kefiran solutions were influenced by the extraction parameters. Degradation of the polymer chain occurred at the highest temperature tested (100 °C). The intrinsic viscosity of kefiran solutions (0.1 g·ml-1) varied between 8.24 mPa at 100 °C to 19.32 mPa at 80 °C. Regarding rheological properties, kefiran solutions had characteristics of a Newtonian behaviour in diluted solutions and pseudoplastic at higher concentrations. High-performance liquid chromatography analysis of monosaccharides revealed that kefiran is composed of glucose and galactose in a relative molar ratio of 0.94–1.1. Infrared spectra of kefiran suggested the structure of α- and β-configurations in pyranose-form carbohydrates, which indicated a purified structure of kefiran. The molecular weight of kefiran polymer was between 2.4 × 106 Da and 1.5 × 107 Da, the values of molecular weight depending on extraction conditions. This polysaccharide was found to have higher intrinsic viscosity and higher apparent viscosity in aqueous solutions, which brings a perspective for its use as thickening or gelling agent in food, or as a matrix in film-forming solutions. [less ▲]

Detailed reference viewed: 39 (7 ULg)
Full Text
Peer Reviewed
See detailDurée excessive d'une procédure pénale et mise en cause de la responsabilité civile de l'Etat
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (2016/12), 569-574

Le jugement commenté présente la principale particularité d'aborder la mise en cause de la responsabilité civile de l'Etat en cas de dépassement du délai raisonnable d'une procédure pénale. Le commentaire ... [more ▼]

Le jugement commenté présente la principale particularité d'aborder la mise en cause de la responsabilité civile de l'Etat en cas de dépassement du délai raisonnable d'une procédure pénale. Le commentaire de cette décision s'attache encore à mettre en perspective cette décision avec l'arrêt Panju c. Belgique prononcé le 28 octobre 2014 par la Cour européenne des droits de l'homme. [less ▲]

Detailed reference viewed: 36 (3 ULg)
Full Text
Peer Reviewed
See detailA new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials.
GRENADE, Charlotte ULg; Moniotte, Nicolas; Rompen, Eric ULg et al

in Cytotechnology (2016)

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of ... [more ▼]

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was to develop a reliable in vitro method to study cell behavior on rigid and flexible/permeable biomaterials elaborating two specific insert-based systems (IBS-R and IBS-F respectively). IBS-R was designed as a specific cylindrical polytetrafluoroethylene (PTFE) system to evaluate attachment, proliferation and morphology of human gingival fibroblasts (HGFs) on grade V titanium and lithium disilicate glass-ceramic discs characteristics of dental prostheses. The number of cells, their covering on discs and their morphology were determined from MTS assays and microscopic fluorescent images after 24, 48 and 72 h. IBS-F was developed as a two components system to study HGFs behavior on guided bone regeneration polyester membranes. The viability and the membrane barrier effect were evaluated by metabolic MTS assays and by scanning electron microscopy. IBS-R and IBS-F were shown to promote (1) easy and rapid handling; (2) cell retention on biomaterial surface; (3) accurate evaluation of the cellular proliferation, spreading and viability; (4) use of non-toxic material. Moreover IBS-F allowed the study of the cell migration through degradable membranes, with an access to both faces of the biomaterial and to the bottom of culture wells for medium changing. [less ▲]

Detailed reference viewed: 45 (8 ULg)
Full Text
Peer Reviewed
See detailStratospheric aerosol - Observations, processes, and impact on climate
Kremser, Stefanie; Thomason, Larry W.; von Hobe, Marc et al

in Reviews of Geophysics (Washington, D.C. : 1985) (2016)

Interest in stratospheric aerosol and its role in climate has increased over the last decade due to the observed increase in stratospheric aerosol since 2000 and the potential for changes in the sulfur ... [more ▼]

Interest in stratospheric aerosol and its role in climate has increased over the last decade due to the observed increase in stratospheric aerosol since 2000 and the potential for changes in the sulfur cycle induced by climate change. This review provides an overview about the advances in stratospheric aerosol research since the last comprehensive assessment of stratospheric aerosol was published in 2006. A crucial development since 2006 is the substantial improvement in the agreement between in situ and space-based inferences of stratospheric aerosol properties during volcanically quiescent periods. Furthermore, new measurement systems and techniques, both in situ and space-based, have been developed for measuring physical aerosol properties with greater accuracy and for characterizing aerosol composition. However, these changes induce challenges to constructing a long-term stratospheric aerosol climatology. Currently, changes in stratospheric aerosol levels less than 20% cannot be confidently quantified. The volcanic signals tend to mask any non-volcanically driven change, making them difficult to understand. While the role of carbonyl sulfide (OCS) as a substantial and relatively constant source of stratospheric sulfur has been confirmed by new observations and model simulations, large uncertainties remain with respect to the contribution from anthropogenic sulfur dioxide (SO2) emissions. New evidence has been provided that stratospheric aerosol can also contain small amounts of non-sulfate matter such as black carbon and organics. Chemistry-climate models have substantially increased in quantity and sophistication. In many models the implementation of stratospheric aerosol processes is coupled to radiation and/or stratospheric chemistry modules to account for relevant feedback processes. [less ▲]

Detailed reference viewed: 45 (8 ULg)
Full Text
Peer Reviewed
See detailNon-isocyanate polyurethanes from carbonated soybean oil Using monomeric or oligomeric diamines To achieve thermosets or thermoplastics
Poussard, Loïc; Mariage, J.; Grignard, Bruno ULg et al

in Macromolecules (2016), 49(6), 2162-2171

Fully bio- and CO2-sourced non-isocyanate polyurethanes (NIPUs) were synthesized by reaction of carbonated soybean oil (CSBO) either with biobased short diamines or amino-telechelic oligoamides derived ... [more ▼]

Fully bio- and CO2-sourced non-isocyanate polyurethanes (NIPUs) were synthesized by reaction of carbonated soybean oil (CSBO) either with biobased short diamines or amino-telechelic oligoamides derived from fatty acids to achieve respectively thermoset or thermoplastic NIPUs. Biobased carbonated vegetable oils were first obtained by metal-free coupling reactions of CO2 with epoxidized soybean oils under supercritical conditions (120 °C, 100 bar) before complete characterization by FTIR, 1H NMR, and electrospray ionization mass spectroscopy (ESI-MS). In a second step, biobased NIPUs were produced by melt-blending of the so-produced cyclocarbonated oil with the biobased aminated derivatives. The thermal and mechanical properties of resulting polymers were found to be depending on the cyclocarbonated vegetable oil/amine ratio. More precisely, short diamines and CSBO led to the formation of cross-linked NIPUs, and the resulting tensile and thermal properties were poor. In contrast, elastomeric NIPUs derived from oligoamides and CSBO exhibited a better rigidity, an improved elongation at break (εr up to 400%), and a higher thermal stability (T95 wt% > 350 °C) than those of starting oligoamides. These results are impressive and highlight the potentiality of this environmental friendly approach to prepare renewable NIPU materials of high performances. [less ▲]

Detailed reference viewed: 62 (13 ULg)
Full Text
Peer Reviewed
See detailEstimating carbon fluxes in a Posidonia oceanica system: Paradox of the bacterial carbon demand
Velimirov, Branko; Lejeune, Pierre; Kirschner, A. et al

in Estuarine Coastal & Shelf Science (2016), 171

A mass balance ecosystemic approach, based on bacterial carbon demands and primary production data, was used to investigate if the bacterial community (freewater bacterioplankton and benthic bacteria of ... [more ▼]

A mass balance ecosystemic approach, based on bacterial carbon demands and primary production data, was used to investigate if the bacterial community (freewater bacterioplankton and benthic bacteria of the oxygenated sediment layer) could be sustained by the main primary producers (Posidonia oceanica and its epiphytes, adjacent macroalgae and phytoplankton communities; hereafter called the P. oceanica system) of a non-eutrophic Mediterranean bay. Unexpectedly, the findings of this study differed from previous works that used benthic incubation chamber and O2 optode methods. In this study, data were grouped in two categories, corresponding to two time periods, according to the seawater temperature regime (<18 °C or >18 °C): from May to October and from November to April. Between May and October, the produced benthic macrophyte tissues could not provide the carbon required by the bacteria of the oxygenated sediment layer, showing that the balance production of the investigated bay was clearly heterotrophic (i.e. negative) during this time period. In contrast, between November and April, benthic bacteria respiration nearly equated to carbon production. When integrating the open water carbon dynamics above the meadow in the model, a negative carbon balance was still observed between May and October, while a slight carbon excess was noticed between November and April. In the light of these findings, the carbon balance being negative on an annual basis, alternative carbon sources are required for the maintenance of the bacterial carbon production. [less ▲]

Detailed reference viewed: 97 (44 ULg)
Full Text
Peer Reviewed
See detailChecklist of Aphidiinae (Hymenoptera: Braconidae) and Aphelinus (Hymenoptera: Aphelinidae) species from Belgium with respectively four and three new records
Chevalier Mendes Lopes, Thomas ULg; Libert, Pierre-Nicolas; Starý, Petr et al

in Zootaxa (2016), 4092(4)

Aphid parasitoids have good potential for crop protection. However, they have been poorly studied in Belgium, especially in terms of species diversity. Therefore, the aim of this work was to establish the ... [more ▼]

Aphid parasitoids have good potential for crop protection. However, they have been poorly studied in Belgium, especially in terms of species diversity. Therefore, the aim of this work was to establish the first checklist for the country. To complete the list, aphid parasitoids were sampled in wheat and pea fields near Gembloux (Belgium), in 2013 and 2014. Among the identified species, Aphelinus asychis Walker, Aphelinus daucicola Kurdjumov, Aphelinus fusciscapus (Förster), Aphidius asteris Haliday, Aphidius eadyi Starý, Gonzalez & Hall, Praon barbatum Mackauer, and Trioxys auctus (Haliday) were recorded for the first time in Belgium. Thirty-two Aphidiinae and seven Aphelinus species were included in the checklist. It is hoped this study will stimulate further research, as species diversity is still low compared with neighbouring countries. [less ▲]

Detailed reference viewed: 38 (6 ULg)
Full Text
Peer Reviewed
See detailProcedural learning as a measure of functional impairment in a mouse model of ischemic stroke
Linden, Jérôme ULg; Van de Beek, Lise; Plumier, Jean-Christophe ULg et al

in Behavioural Brain Research (2016), 307

Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a ... [more ▼]

Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a murine model of stroke (30min. right MCAO), we submitted C57Bl/6J mice to various sensorimotor tests, then to an operant procedure (Serial Order Learning) specifically assessing the ability to learn a simple motor sequence. Results showed that MCAO affected the performance in some of the sensorimotor tests (accelerated rotating rod and amphetamine rotation test) and the way animals learned a motor sequence. The later finding seems to be caused by difficulties regarding the chunking of operant actions into a coherent motor sequence; the appeal for food rewards and ability to press levers appeared unaffected by MCAO. We conclude that assessment of motor learning in rodent models of stroke might improve the translational value of such models. [less ▲]

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailTransition-Metal Carbodiimides as Molecular Negative Electrode Materials for Lithium- and Sodium-Ion Batteries with Excellent Cycling Properties
sougrati, Moulay Tahar; Darwiche, Ali; Liu, Xiaohiu et al

in Angewandte Chemie International Edition (2016), 55(16), 5090-5095

We report evidence for the electrochemical activity of transition-metal carbodiimides versus lithium and sodium. In particular, iron carbodiimide, FeNCN, can be efficiently used as negative electrode ... [more ▼]

We report evidence for the electrochemical activity of transition-metal carbodiimides versus lithium and sodium. In particular, iron carbodiimide, FeNCN, can be efficiently used as negative electrode material for alkali-metal-ion batteries, similar to its oxide analogue FeO. Based on 57Fe Mossbauer and infrared spectroscopy (IR) data, the electrochemical reaction mechanism can be explained by the reversiblevtransformation of the FeNCN into Li/NaNCN bonds during discharge and charge. These new electrode materials exhibit higher capacity compared to well-established negative electrode references such as graphite or hard carbon. Contrary to its oxide analogue, iron carbodiimide does not require heavy treatments (such as nanoscale tailoring, sophisticated textures, or coating) to obtain long cycle life with current density as high as 9 Ag-1 for hundreds of charge–discharge cycles. Similar to the iron compound, several other transition-metal carbodiimides Mx(NCN)y with M=Mn, Cr, Zn can cycle successfully versus lithium and sodium. Their electrochemical activity and performance open the way to the design of a novel family of anode materials. [less ▲]

Detailed reference viewed: 9 (4 ULg)
Full Text
Peer Reviewed
See detailFrom commensalism to parasitism in Carapidae (Ophidiiformes): heterochronic modes of development?
Parmentier, Eric ULg; Lanterbecq, Déborah; Eeckhaut, Igor

in PeerJ (2016), 4

Detailed reference viewed: 17 (4 ULg)
Full Text
Peer Reviewed
See detailStructural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B
Rondelet, Grégoire; Dal Maso, Thomas; Willems, Luc ULg et al

in Journal of Structural Biology (2016), 194

DNA methylation is an important epigenetic modification involved in chromatin organization and gene expression. The function of DNA methylation depends on cell context and is correlated with histone ... [more ▼]

DNA methylation is an important epigenetic modification involved in chromatin organization and gene expression. The function of DNA methylation depends on cell context and is correlated with histone modification patterns. In particular, trimethylation of Lys36 on histone H3 tail (H3K36me3) is associated with DNA methylation and elongation phase of transcription. PWWP domains of the de novo DNA methyltransferases DNMT3A and DNMT3B read this epigenetic mark to guide DNA methylation. Here we report the first crystal structure of the DNMT3B PWWP domain–H3K36me3 complex. Based on this structure, we propose a model of the DNMT3A PWWP domain–H3K36me3 complex and build a model of DNMT3A (PWWP-ADD-CD) in a nucleosomal context. The trimethylated side chain of Lys36 (H3K36me3) is inserted into an aromatic cage similar to the ‘‘Royal” superfamily domains known to bind methylated histones. A key interaction between trimethylated Lys36 and a conserved water molecule stabilized by Ser270 explains the lack of affinity of mutated DNMT3B (S270P) for the H3K36me3 epigenetic mark in the ICF (Immunodeficiency, Centromeric instability and Facial abnormalities) syndrome. The model of the DNMT3A-DNMT3L heterotetramer in complex with a dinucleosome highlights the mechanism for recognition of nucleosome by DNMT3s and explains the periodicity of de novo DNA methylation. [less ▲]

Detailed reference viewed: 17 (4 ULg)
Full Text
Peer Reviewed
See detailDepressive symptomatology and the influence of the behavioral avoidance and activation: A gender-specific investigation
Wagener, Aurélie ULg; Baeyens, Céline; Blairy, Sylvie ULg

in Journal of Affective Disorders (2016), 193

BACKGROUNG: Depression is a highly prevalent disorder which is usually considered as differentially experienced depending on gender. Behavioral theories of depression pinpoint the importance of the ... [more ▼]

BACKGROUNG: Depression is a highly prevalent disorder which is usually considered as differentially experienced depending on gender. Behavioral theories of depression pinpoint the importance of the behavioral avoidance in the maintenance of depression. However, little is known about the specific impact of the behavioral avoidance and activation on each depressive symptom as well as on gender differences on the behavioral features of depression. METHODS: This study’s aim was two-fold: (1) to assess the presence of gender differences on the BDI-II; (2) to investigate the respective predictive value of behavioral avoidance and of behavioral activation on each depressive symptom assessed by the BDI-II depending on gender. Community adults and adults attending mental healthcare composed the sample. RESULTS: Results showed differences in symptomatology profiles depending on gender (e.g. higher scores of sadness, self-criticalness in women, higher scores of past failure and loss of pleasure in men). Behavioral avoidance positively predicted almost all depressive symptoms in women and in men while behavioral activation negatively predicted almost all symptoms in both gender. Nevertheless, the strengths of these relationships were different for some symptoms (e.g. pessimism). LIMITATIONS: The use of self-report instruments; the lack of assessment of causal or precipitating factors of the depressive symptomatology; the higher number of women in the sample. CONCLUSIONS: Results are discussed with respect to previous findings and present clinical implications: (1) to underline the relevance of the combination of gender-specific assessment tools; (2) to highlight the need of tailored psychological intervention. [less ▲]

Detailed reference viewed: 30 (5 ULg)
Full Text
Peer Reviewed
See detailRetrieval of HCFC-142b (CH3CClF2) from ground-based high-resolution infrared solar spectra: Atmospheric increase since 1989 and comparison with surface and satellite measurements
Mahieu, Emmanuel ULg; Lejeune, Bernard ULg; Bovy, Benoît ULg et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2016)

We have developed an approach for retrieving HCFC-142b (CH3CClF2) from ground-based high-resolution infrared solar spectra, using its ν7 band Q branch in the 900–906 cm-1 interval. Interferences by HNO3 ... [more ▼]

We have developed an approach for retrieving HCFC-142b (CH3CClF2) from ground-based high-resolution infrared solar spectra, using its ν7 band Q branch in the 900–906 cm-1 interval. Interferences by HNO3, CO2 and H2O have to be accounted for. Application of this approach to observations recorded within the framework of long-term monitoring activities carried out at the northern mid-latitude, high-altitude Jungfraujoch station in Switzerland (46.5°N, 8.0°E, 3580 m above sea level) has provided a total column times series spanning the 1989 to mid-2015 time period. A fit to the HCFC-142b daily mean total column time series shows a statistically-significant long-term trend of (1.23±0.08×1013 molec cm-2) per year from 2000 to 2010, at the 2-σ confidence level. This corresponds to a significant atmospheric accumulation of (0.94±0.06) ppt (1 ppt=10-12) per year for the mean tropospheric mixing ratio, at the 2−σ confidence level. Over the subsequent time period (2010–2014), we note a significant slowing down in the HCFC-142b buildup. Our ground-based FTIR (Fourier Transform Infrared) results are compared with relevant data sets derived from surface in situ measurements at the Mace Head and Jungfraujoch sites of the AGAGE (Advanced Global Atmospheric Gases Experiment) network and from occultation measurements by the ACE-FTS (Atmospheric Chemistry Experiment-Fourier Transform Spectrometer) instrument on-board the SCISAT satellite. [less ▲]

Detailed reference viewed: 25 (8 ULg)
Full Text
Peer Reviewed
See detailThe transition to conservation agriculture : an insularization process towards sustainability
Vankeerberghen, Audrey ULg; Stassart, Pierre M ULg

in International Journal of Agricultural Sustainability (2016)

Part of the Sustainability Transition Studies, this work addresses the question of the relationship between niches and regimes by examining the transition to conservation agriculture. It seeks to ... [more ▼]

Part of the Sustainability Transition Studies, this work addresses the question of the relationship between niches and regimes by examining the transition to conservation agriculture. It seeks to understand how farmers' transition to conservation agriculture can contribute to a better understanding of the transition of agro-food systems towards sustainability. Based on an analysis of farmers' trajectories in the Walloon region in Belgium, the paper develops the notion of insularization in order to characterize the emergence of conservation agriculture as a niche that is a dynamic process, growing from within and progressively detaching itself from the conventional agricultural regime. The analysis of farmers' transition shows how, after an initial phase of destabilization of the conventional ploughing regime, learning and experiencing processes can lead to a transformation in soil and soil quality management perceptions. Our hypothesis is that this cognitive transformation constitutes a tipping point in the insularization process because of its effects on agricultural practices, which increase the detachment of conservation agriculture from the regime and thus embed the irreversibility and sustainability of the transition. The term insularization is used to describe an ecologization pathway of agricultural practices endogenous to the regime that can not only lead to adaptive changes on the periphery of the system, but might also induce a deep and systemic transformation of conventional agricultural practices. [less ▲]

Detailed reference viewed: 135 (40 ULg)
Full Text
Peer Reviewed
See detailEffect of DOPA and dopamine coupling on protein loading of hydroxyapatite
Ozhukil Kollath, Vinayaraj ULg; Mullens, Steven; Luyten, Jan et al

in Materials Technology: Advanced Performance Materials (2016)

Hydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine ... [more ▼]

Hydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine. This study reports the surface functionalisation of HA particles using the mussel inspired molecules dopamine (DA) and 3,4-dihydroxy-L-phenylalanine (DOPA), in order to increase protein loading. The adsorption mechanisms are discussed based on the adsorption isotherms, zeta potential, thermal analysis and theoretical models. Results show that DA functionalisation enhanced the loading, while DOPA functionalisation was ineffective. [less ▲]

Detailed reference viewed: 25 (9 ULg)
Full Text
Peer Reviewed
See detailTerpenoids from Phaulopsis imbricata (Acanthaceae)
Kengne, A.B.O.; Tene, M.; Tchinda Tiabou, Alembert ULg et al

in Journal of Medicinal Plants Research (2016), 10(10), 122-129

The whole plant of Phaulopsis imbricata (Forssk.) Sweet (Acanthaceae) was collected at Bansoa, Cameroon, shade dried and extracted by maceration in methanol. This study was carried out to isolate ... [more ▼]

The whole plant of Phaulopsis imbricata (Forssk.) Sweet (Acanthaceae) was collected at Bansoa, Cameroon, shade dried and extracted by maceration in methanol. This study was carried out to isolate secondary metabolites from this plant species that has not been investigated so far. Two lupane-type triterpenoids, one β-type carotenoid, one eudesmane-type sesquiterpenoid, and one sterol glycoside were isolated from the dried methanol extract using solvent partitioning, column chromatography and re-crystallization. They were identified as lupeol, betulin, (all-E)-lutein, cryptomeridiol, and sitosterol 3- O-β-D-glucopyranoside, respectively. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods including 1D- and 2D- nuclear magnetic resonance (NMR), infrared (IR) and mass spectrometry (MS). This is the first report of these compounds from the genus Phaulopsis. To the best of our knowledge, P. imbricata is also the first species of the genus to be phytochemically studied. [less ▲]

Detailed reference viewed: 25 (9 ULg)
Full Text
Peer Reviewed
See detailResponse of CO2 fluxes and productivity to water availability in two contrasting ecosystems in northern Benin (West Africa)
Ago, Expédit Evariste ULg; Agbossou, Euloge Kossi; Cohard, Jean-Martial et al

in Annals of Forest Science (2016)

Detailed reference viewed: 27 (5 ULg)
Full Text
Peer Reviewed
See detailThree-parameter kinematic theory for shear-dominated reinforced concrete walls
Mihaylov, Boyan ULg; Hannewald, Pia; Beyer, Katrin

in Journal of Structural Engineering (2016)

This paper is aimed at addressing the need for physically accurate and computationally effective models for predicting the response of shear-dominated reinforced concrete walls. The presented theory is ... [more ▼]

This paper is aimed at addressing the need for physically accurate and computationally effective models for predicting the response of shear-dominated reinforced concrete walls. The presented theory is based on a three-degree-of-freedom kinematic model for the deformation patterns in walls with aspect ratios smaller than approximately 3. In the kinematic model, the wall is divided into two parts—a rigid block and a fan of struts—by a diagonal crack. The mechanisms of shear resistance across this crack are modeled with nonlinear springs to capture the prepeak and postpeak shear behavior of the member. The base section of the wall is also modeled to account for yielding of the reinforcement and crushing of the concrete. It is shown that this approach captures well the global and local deformations measured in a test specimen with detailed instrumentation. A more comprehensive validation of the theory is performed with 34 wall tests from the literature. The obtained peak load experimental-to-predicted ratios have an average of 1.03 with a coefficient of variation of 11.6%, while these values for the drift capacity are 0.99 and 16.4%. [less ▲]

Detailed reference viewed: 28 (7 ULg)
Full Text
Peer Reviewed
See detailProduction of two entomopathogenic Aspergillus species and insecticidal activity against the mosquito Culex quinquefasciatus compared to Metarhizium anisopliae
Bawin, Thomas ULg; Seye, Fawrou; Boukraa, Slimane ULg et al

in Biocontrol Science & Technology (2016), 26(5), 617-629

Entomopathogenic micro-organisms including fungi have become increasingly studied for integrated pest management. The spore productivity and insecticidal activity of two opportunistic insect pathogenic ... [more ▼]

Entomopathogenic micro-organisms including fungi have become increasingly studied for integrated pest management. The spore productivity and insecticidal activity of two opportunistic insect pathogenic Aspergillus species (namely: Aspergillus clavatus Desmazieres and Aspergillus flavus Link (Ascomycota: Eurotiales, Trichocomaceae)) were compared to Metarhizium anisopliae sensu lato (Metchnikoff) Sorokin (Ascomycota: Hypocreales, Clavicipitaceae) for mosquito (Diptera: Culicidae) control. The production of aerial spores on wheat bran and white rice was investigated in solid-, semi-solid-, and liquid-state media supplemented with a nutritive solution. Wheat bran-based media were suitable for spore production and increased the spore yield in solid-state from 3 to 7 fold: A. clavatus produced 48.4 ± 5.2 and 15.7 ± 1.6 x 10^8 spores/g, A. flavus produced 22.3 ± 4.1 and 3.1 ± 2.5 x 10^8 spores/g, and M. anisopliae produced 39.6 ± 6.5 and 13.1 ± 2.6 x 10^8 spores/g of wheat bran or white rice, respectively. A. clavatus, A. flavus and M. anisopliae spores harvested from wheat bran-based solid-state media showed lethal concentrations (LC50) of 1.1, 1.8, and 1.3 x 10^8 spores/ml against Culex quinquefasciatus Say larvae in 72 h. Because A. clavatus and M. anisopliae displayed similar features when cultured under these conditions, our results suggest that insect pathogenic Aspergillus species may be as productive and virulent against mosquito larvae as a well-recognized entomopathogenic fungus. Wheat bran could advantageously be used in large-scale fermentation for a possible cost-effective pest control using these fungi. [less ▲]

Detailed reference viewed: 46 (11 ULg)
Full Text
Peer Reviewed
See detailExtinction of fish-shaped marine reptiles associated with reduced evolutionary rates and global environmental volatility
Fischer, Valentin ULg; Bardet, Nathalie; Benson, Roger et al

in Nature Communications (2016), 7(10825), 1-11

Despite their profound adaptations to the aquatic realm and their apparent success throughout the Triassic and the Jurassic, ichthyosaurs became extinct roughly 30 million years before the end-Cretaceous ... [more ▼]

Despite their profound adaptations to the aquatic realm and their apparent success throughout the Triassic and the Jurassic, ichthyosaurs became extinct roughly 30 million years before the end-Cretaceous mass extinction. Current hypotheses for this early demise involve relatively minor biotic events, but are at odds with recent understanding of the ichthyosaur fossil record. Here, we show that ichthyosaurs maintained high but diminishing richness and disparity throughout the Early Cretaceous. The last ichthyosaurs are characterized by reduced rates of origination and phenotypic evolution and their elevated extinction rates correlate with increased environmental volatility. In addition, we find that ichthyosaurs suffered from a profound Early Cenomanian extinction that reduced their ecological diversity, likely contributing to their final extinction at the end of the Cenomanian. Our results support a growing body of evidence revealing that global environmental change resulted in a major, temporally staggered turnover event that profoundly reorganized marine ecosytems during the Cenomanian. [less ▲]

Detailed reference viewed: 62 (14 ULg)
Full Text
Peer Reviewed
See detailPerformance variation of common ragweed (Ambrosia artemisiifolia L.) across invasion levels in Western Europe
Ortmans, William ULg; Mahy, Grégory ULg; Chauvel, Bruno et al

in Flora (2016), 220

The occurrence of an invasive plant across a continent is generally not homogeneous; typically, some areas are highly invaded whereas others show moderate or low invasion levels. This situation might be a ... [more ▼]

The occurrence of an invasive plant across a continent is generally not homogeneous; typically, some areas are highly invaded whereas others show moderate or low invasion levels. This situation might be a snapshot of an ongoing spread, but it could also remain stable under the pressure of factors that constrain the invasion. Among those factors, plant performance variation among invasion levels can explain an invasion slowdown. However, few studies have investigated the large-scale variation of invasive plant performance in the field. Ambrosia artemisiifolia L. in Western Europe represents a good opportunity to address this issue, with areas of high, moderate and low invasion levels being documented across a ca. 1000 km transect. In this study, we compared in situ plant performance-related traits in 12 populations from areas of contrasting invasion levels. We also tested whether performance-related traits were influenced by the intra-and inter-specific competition, by the local climatic conditions or by latitude (a proxy for growing season length). Overall, we did not find differences in performance-related traits across invasion levels, and intra-and inter-specific competition had low effects on plant performance. This study highlights the fact that A. artemisiifolia individuals express similar performance across invasion levels, even beyond what can be considered the present invasion front. Further research has to expand this study northwards, and assess other factors that could constrain the invasion in order to highlight if the species invasion northward is constrained or if it has the potential to invade new areas. [less ▲]

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailPerformance of a radial-inflow turbine integrated in an ORC system and designed for a WHR on truck application: An experimental comparison between R245fa and R1233zd
Guillaume, Ludovic ULg; Legros, Arnaud ULg; Desideri, Adriano ULg et al

in Applied Energy (2016)

The goal of this study is to experimentally compare the performance of an Organic Rankine Cycle (ORC) system equipped with a radial-inflow turbine for two working fluids: R245fa and R1233zd. The radial ... [more ▼]

The goal of this study is to experimentally compare the performance of an Organic Rankine Cycle (ORC) system equipped with a radial-inflow turbine for two working fluids: R245fa and R1233zd. The radial- inflow turbine is a small-scale prototype designed to convert the waste heat from the exhaust gases of a truck combustion engine and was developed mainly using components of truck turbochargers. It is directly connected to a high-speed synchronous generator. The bearings system of the turbine and the generator have the innovative particularity to be respectively lubricated and cooled down by the working fluid so no additional lubricant or coolant is needed. The experimental comparison is carried out over a test-rig equipped with the radial turbine. The heat wasted by the truck through the exhaust gases is sim- ulated using an electric oil boiler coupled to the ORC loop. The electrical power supplied by the turbine, limited to a maximum of 3.5 kWel by the generator, is then dissipated in a load bank composed of truck fans while the condenser is cooled by a water loop. Measurements in steady-state are performed in order to evaluate the performance of the turbine-generator set when varying the pressure ratio, the rotational speed, the inlet temperature and the mass flow rate of the turbine and the lubrication flow rate of the bearings for various oil temperatures and mass flow rates. In order to identify the most suitable fluid for the Waste Heat Recovery (WHR) application, three comparison methods are proposed and discussed based on the measurements. Finally, because the turbine-generator set is the first oil-free prototype developed by the manufacturer, potential sources of improvements are discovered and discussed. [less ▲]

Detailed reference viewed: 30 (6 ULg)
Full Text
Peer Reviewed
See detailDynamic calibration of piezoelectric transducers for ballistic high-pressure measurement
Elkarous, Lamine ULg; Robbe, Cyril; Pirlot, Marc et al

in International Journal of Metrology and Quality Engineering (2016)

Detailed reference viewed: 48 (16 ULg)
Full Text
Peer Reviewed
See detailLe casier judiciaire : un instrument mémoriel au passé tourmenté mais à l’avenir empreint de sérénité ?
Seron, Vincent ULg

in Journal des Tribunaux (2016)

Profondément réformé en 1997, le casier judiciaire n’en finit pas de faire l’objet de remaniements et de prêter le flanc à la critique. Des modifications régulièrement opérées s’agissant de la délivrance ... [more ▼]

Profondément réformé en 1997, le casier judiciaire n’en finit pas de faire l’objet de remaniements et de prêter le flanc à la critique. Des modifications régulièrement opérées s’agissant de la délivrance de ses extraits à sa mise à jour lacunaire, nombreux sont les éléments qui témoignent des difficultés récurrentes auxquelles cet instrument séculaire est confronté. En quatre temps, cet article propose de remettre en perspective les principaux éléments explicatifs de l’état transitoire au sein duquel le casier judiciaire est confiné depuis près de deux décennies, d’analyser son fonctionnement actuel, de focaliser l’attention sur les récents changements apportés à son contenu ainsi qu’à la communication des données qu’il contient, et de s’interroger sur la prétendue non fiabilité de ce casier. [less ▲]

Detailed reference viewed: 34 (6 ULg)
Full Text
Peer Reviewed
See detailThe darkening of the Greenland ice sheet: trends, drivers, and projections (1981–2100)
Tedesco, M.; Doherty, S.; Fettweis, Xavier ULg et al

in Cryosphere (The) (2016), 10

The surface energy balance and meltwater production of the Greenland ice sheet (GrIS) are modulated by snow and ice albedo through the amount of absorbed solar radiation. Here we show, using space-borne ... [more ▼]

The surface energy balance and meltwater production of the Greenland ice sheet (GrIS) are modulated by snow and ice albedo through the amount of absorbed solar radiation. Here we show, using space-borne multispectral data collected during the 3 decades from 1981 to 2012, that summertime surface albedo over the GrIS decreased at a statistically significant (99 %) rate of 0.02 decade−1 between 1996 and 2012. Over the same period, albedo modelled by the Modèle Atmosphérique Régionale (MAR) also shows a decrease, though at a lower rate ( ∼ −0.01 decade−1) than that obtained from space-borne data. We suggest that the discrepancy between modelled and measured albedo trends can be explained by the absence in the model of processes associated with the presence of light-absorbing impurities. The negative trend in observed albedo is confined to the regions of the GrIS that undergo melting in summer, with the dry-snow zone showing no trend. The period 1981–1996 also showed no statistically significant trend over the whole GrIS. Analysis of MAR outputs indicates that the observed albedo decrease is attributable to the combined effects of increased near-surface air temperatures, which enhanced melt and promoted growth in snow grain size and the expansion of bare ice areas, and to trends in light-absorbing impurities (LAI) on the snow and ice surfaces. Neither aerosol models nor in situ and remote sensing observations indicate increasing trends in LAI in the atmosphere over Greenland. Similarly, an analysis of the number of fires and BC emissions from fires points to the absence of trends for such quantities. This suggests that the apparent increase of LAI in snow and ice might be related to the exposure of a "dark band" of dirty ice and to increased consolidation of LAI at the surface with melt, not to increased aerosol deposition. Albedo projections through to the end of the century under different warming scenarios consistently point to continued darkening, with albedo anomalies averaged over the whole ice sheet lower by 0.08 in 2100 than in 2000, driven solely by a warming climate. Future darkening is likely underestimated because of known underestimates in modelled melting (as seen in hindcasts) and because the model albedo scheme does not currently include the effects of LAI, which have a positive feedback on albedo decline through increased melting, grain growth, and darkening. [less ▲]

Detailed reference viewed: 129 (5 ULg)
Full Text
Peer Reviewed
See detailSomatic mosaicism underlies X-linked acrogigantism (XLAG) syndrome in sporadic male subjects
Daly, Adrian ULg; Yuan, Bo; Fina, Frederic et al

in Endocrine-Related Cancer (2016)

Somatic mosaicism has been implicated as a causative mechanism in a number of genetic and genomic disorders. X-linked acrogigantism (XLAG) syndrome is a recently characterized genomic form of pediatric ... [more ▼]

Somatic mosaicism has been implicated as a causative mechanism in a number of genetic and genomic disorders. X-linked acrogigantism (XLAG) syndrome is a recently characterized genomic form of pediatric gigantism due to aggressive pituitary tumors that is caused by submicroscopic chromosome Xq26.3 duplications that include GPR101. We studied XLAG syndrome patients (N=18) to determine if somatic mosaicism contributed to the genomic pathophysiology. Eighteen subjects with XLAG syndrome were identified with Xq26.3 duplications using high definition array comparative genome hybridization (HD-aCGH). We noted males with XLAG had a decreased log2 ratio compared with expected values, suggesting potential mosaicism, while females showed no such decrease. As compared with familial male XLAG cases, sporadic males had more marked evidence for mosaicism, with levels of Xq26.3 duplication between 16.1-53.8%. These characteristics were replicated using a novel, personalized breakpoint-junction specific quantification droplet digital PCR (ddPCR) technique. Using a separate ddPCR technique we studied the feasibility of identifying XLAG syndrome cases in a distinct patient population of 64 unrelated subjects with acromegaly/gigantism and identified one female gigantism patient that had increased copy number variation (CNV) threshold for GPR101 that was subsequently diagnosed as having XLAG syndrome on HD-aCGH. Employing a combination of HD-aCGH and novel ddPCR approaches, we have demonstrated that XLAG syndrome can be caused by variable degrees of somatic mosaicism for duplications at chromosome Xq26.3. Somatic mosaicism was shown to occur in sporadic males but not in females with XLAG syndrome, although the clinical characteristics of the disease were similarly severe in both sexes. [less ▲]

Detailed reference viewed: 51 (27 ULg)
Full Text
Peer Reviewed
See detailSpectral statistics of chaotic many-body systems
Dubertrand, Rémy ULg

in New Journal of Physics (2016), 18

We derive a trace formula that expresses the level density of chaotic many-body systems as a smooth term plus a sum over contributions associated to solutions of the nonlinear Schrödinger (or ... [more ▼]

We derive a trace formula that expresses the level density of chaotic many-body systems as a smooth term plus a sum over contributions associated to solutions of the nonlinear Schrödinger (or Gross–Pitaevski) equation. Our formula applies to bosonic systems with discretised positions, such as the Bose–Hubbard model, in the semiclassical limit as well as in the limit where the number of particles is taken to infinity. We use the trace formula to investigate the spectral statistics of these systems, by studying interference between solutions of the nonlinear Schrödinger equation. We show that in the limits taken the statistics of fully chaotic many-particle systems becomes universal and agrees with predictions from the Wigner–Dyson ensembles of random matrix theory. The conditions for Wigner–Dyson statistics involve a gap in the spectrum of the Frobenius–Perron operator, leaving the possibility of different statistics for systems with weaker chaotic properties. [less ▲]

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailCoordination des soins en première ligne de soins: et Mme Dupont?
Belche, Jean ULg; Buret, Laetitia ULg; Duchesnes, Christiane ULg et al

in Santé Conjuguée (2016), 74

Detailed reference viewed: 26 (8 ULg)
Full Text
See detailThe Central Role of FORS1/2 Spectropolarimetric Observations for the Progress of Stellar Magnetism Studies
Schöller, M.; Hubrig, S.; Ilyin, I. et al

in The Messenger (2016), 163

The spectropolarimetric mode of the FOcal Reducer and low dispersion Spectrographs (FORS), which was first implemented in FORS1, and then moved to FORS2 seven years ago, has made it possible to probe the ... [more ▼]

The spectropolarimetric mode of the FOcal Reducer and low dispersion Spectrographs (FORS), which was first implemented in FORS1, and then moved to FORS2 seven years ago, has made it possible to probe the presence of magnetic fields in stars of different spectral classes at almost all stages of stellar evolution. While in the early days of FORS1, many of the observations were related to magnetic Ap/Bp stars and their progenitor Herbig Ae/Be stars, recent spectropolarimetric studies with FORS2 have involved more challenging targets, such as massive O- and B-type stars in clusters and in the field, very fast rotating massive stars with magnetospheres, Wolf-Rayet stars and central stars of planetary nebulae. The role of FORS observations for stellar magnetic field measurements is summarised and improvements in the measurement technique are described. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailThe compositional evolution of C/2012 S1 (ISON) from ground-based high-resolution infrared spectroscopy as part of a worldwide observing campaign
Dello Russo, N.; Vervack, R. J.; Kawakita, H. et al

in Icarus (2016), 266

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ∼ 2.5 × 10[SUP]4[/SUP ... [more ▼]

Volatile production rates, relative abundances, rotational temperatures, and spatial distributions in the coma were measured in C/2012 S1 (ISON) using long-slit high-dispersion (λ/Δλ ∼ 2.5 × 10[SUP]4[/SUP]) infrared spectroscopy as part of a worldwide observing campaign. Spectra were obtained on UT 2013 October 26 and 28 with NIRSPEC at the W.M. Keck Observatory, and UT 2013 November 19 and 20 with CSHELL at the NASA IRTF. H[SUB]2[/SUB]O was detected on all dates, with production rates increasing markedly from (8.7 ± 1.5) × 10[SUP]27[/SUP] molecules s[SUP]-1[/SUP] on October 26 (R[SUB]h[/SUB] = 1.12 AU) to (3.7 ± 0.4) × 10[SUP]29[/SUP] molecules s[SUP]-1[/SUP] on November 20 (R[SUB]h[/SUB] = 0.43 AU). Short-term variability of H[SUB]2[/SUB]O production is also seen as observations on November 19 show an increase in H[SUB]2[/SUB]O production rate of nearly a factor of two over a period of about 6 h. C[SUB]2[/SUB]H[SUB]6[/SUB], CH[SUB]3[/SUB]OH and CH[SUB]4[/SUB] abundances in ISON are slightly depleted relative to H[SUB]2[/SUB]O when compared to mean values for comets measured at infrared wavelengths. On the November dates, C[SUB]2[/SUB]H[SUB]2[/SUB], HCN and OCS abundances relative to H[SUB]2[/SUB]O appear to be within the range of mean values, whereas H[SUB]2[/SUB]CO and NH[SUB]3[/SUB] were significantly enhanced. There is evidence that the abundances with respect to H[SUB]2[/SUB]O increased for some species but not others between October 28 (R[SUB]h[/SUB] = 1.07 AU) and November 19 (R[SUB]h[/SUB] = 0.46 AU). The high mixing ratios of H[SUB]2[/SUB]CO/CH[SUB]3[/SUB]OH and C[SUB]2[/SUB]H[SUB]2[/SUB]/C[SUB]2[/SUB]H[SUB]6[/SUB] on November 19, and changes in the mixing ratios of some species with respect to H[SUB]2[/SUB]O between October 28 to November 19, indicates compositional changes that may be the result of a transition from sampling radiation-processed outer layers in this dynamically new comet to sampling more pristine natal material as the outer processed layer was increasingly eroded and the thermal wave propagated into the nucleus as the comet approached perihelion for the first time. On November 19 and 20, the spatial distribution for dust appears asymmetric and enhanced in the antisolar direction, whereas spatial distributions for volatiles (excepting CN) appear symmetric with their peaks slightly offset in the sunward direction compared to the dust. Spatial distributions for H[SUB]2[/SUB]O, HCN, C[SUB]2[/SUB]H[SUB]6[/SUB], C[SUB]2[/SUB]H[SUB]2[/SUB], and H[SUB]2[/SUB]CO on November 19 show no definitive evidence for significant contributions from extended sources; however, broader spatial distributions for NH[SUB]3[/SUB] and OCS may be consistent with extended sources for these species. Abundances of HCN and C[SUB]2[/SUB]H[SUB]2[/SUB] on November 19 and 20 are insufficient to account for reported abundances of CN and C[SUB]2[/SUB] in ISON near this time. Differences in HCN and CN spatial distributions are also consistent with HCN as only a minor source of CN in ISON on November 19 as the spatial distribution of CN in the coma suggests a dominant distributed source that is correlated with dust and not volatile release. The spatial distributions for NH[SUB]3[/SUB] and NH[SUB]2[/SUB] are similar, suggesting that NH[SUB]3[/SUB] is the primary source of NH[SUB]2[/SUB] with no evidence of a significant dust source of NH[SUB]2[/SUB]; however, the higher production rates derived for NH[SUB]3[/SUB] compared to NH[SUB]2[/SUB] on November 19 and 20 remain unexplained. This suggests a more complete analysis that treats NH[SUB]2[/SUB] as a distributed source and accounts for its emission mechanism is needed for future work. [less ▲]

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailMaking sense of residues on flaked stone artefacts: learning from blind tests
Rots, Veerle ULg; Hayes, Elspeth; Cnuts, Dries ULg et al

in PLoS ONE (2016)

Detailed reference viewed: 84 (9 ULg)
Full Text
See detailDix références incontournables pour comprendre l'histoire urbaine des universités
Frankignoulle, Pierre ULg

in Dérivations. Pour le débat urbain. (2016), 2

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detailStructural identifiability analysis of a cardiovascular system model
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

in Medical engineering & physics (2016)

The six-chamber cardiovascular system model of Burkhoff and Tyberg has been used in several theoretical and experimental studies. However, this cardiovascular system model (and others derived from it) are ... [more ▼]

The six-chamber cardiovascular system model of Burkhoff and Tyberg has been used in several theoretical and experimental studies. However, this cardiovascular system model (and others derived from it) are not identifiable from any output set. In this work, two such cases of structural non-identifiability are first presented. These cases occur when the model output set only contains a single type of information (pressure or volume). A specific output set is thus chosen, mixing pressure and volume information and containing only a limited number of clinically available measurements. Then, by manipulating the model equations involving these outputs, it is demonstrated that the six-chamber cardiovascular system model is structurally globally identifiable. A further simplification is made, assuming known cardiac valve resistances. Because of the poor practical identifiability of these four parameters, this assumption is usual. Under this hypothesis, the six-chamber cardiovascular system model is structurally identifiable from an even smaller dataset. As a consequence, parameter values computed from limited but well-chosen datasets are theoretically unique. This means that the parameter identification procedure can safely be performed on the model from such a well-chosen dataset. Thus, the model may be considered suitable for use in diagnosis. [less ▲]

Detailed reference viewed: 32 (5 ULg)
Full Text
Peer Reviewed
See detailControlling the profile of high aspect ratio gratings in diamond
Vargas Catalan, Ernesto; Forsberg, Pontus; Absil, Olivier ULg et al

in Diamond & Related Materials (2016), 63

Diamond is an excellent material for infrared optics and for applications in harsh environments. Some of those desirable properties, i.e. hardness and chemical inertness, also make it a challenging ... [more ▼]

Diamond is an excellent material for infrared optics and for applications in harsh environments. Some of those desirable properties, i.e. hardness and chemical inertness, also make it a challenging material to machine and etch. In this study we have tested a wide range of etch parameters in an inductively coupled plasma etcher, in order to produce highly controlled, high aspect ratio gratings in diamond. We discuss the effects of pressure, bias power, and some gas mixture variation (pure oxygen and argon-oxygen) on the etch results and how it impacts the etch mask sputtering and redeposition. We also present a method for applying a fresh aluminum mask, in order to etch even deeper optical grating. Gratings with aspect ratios as high as 1:13.5 have been achieved with a 1.42 μm grating period. [less ▲]

Detailed reference viewed: 40 (4 ULg)
Full Text
Peer Reviewed
See detailTraumatologie du joueur de tennis
Kaux, Jean-François ULg; Schaus, Jean; Delvaux, François ULg et al

in Journal de Traumatologie du Sport (2016), 33(1), 43-47

Tennis is a racquet sport with approximately 10 million licensees and 26 million unaffiliated players in Europe. Tennis injuries represent 21%of those generated by rackets sports. Tennis players are ... [more ▼]

Tennis is a racquet sport with approximately 10 million licensees and 26 million unaffiliated players in Europe. Tennis injuries represent 21%of those generated by rackets sports. Tennis players are subject to traumatic and microtraumatic pathologies. This epidemiological review oftennis-related injuries addresses their type and locations, the cause and time of absence, the demographic and gender differences, as well as theinfluence of technique of play and type of field on their impact. [less ▲]

Detailed reference viewed: 57 (12 ULg)
Full Text
Peer Reviewed
See detailLa vignette diagnostique de l’étudiant. L’importance du facteur temps et de la chronologie des événements dans l’anamnèse médicale
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71

Summary : Medical history taking represents a key step in the diagnostic approach. A structured interview with a special attention to the chronology of events is mandatory. The medical student often fails ... [more ▼]

Summary : Medical history taking represents a key step in the diagnostic approach. A structured interview with a special attention to the chronology of events is mandatory. The medical student often fails to use the information on time in an optimal way. The aim of this article is to draw the attention on a few key elements, especially the age of the patient, the duration of symptoms, the time of occurrence of complaints within the 24h period and, finally, how to interpret the simultaneous or sequential occurrence of two (or more) events. [less ▲]

Detailed reference viewed: 26 (5 ULg)
Full Text
Peer Reviewed
See detailDrying induced shrinkage of Boom Clay: an experimental investigation
Prime, Noémie; Levasseur, Séverine; Miny, Laurent et al

in Canadian Geotechnical Journal (2016), 53(3), 396-409

Drying induced shrinkage of geomaterials may have a strong effect on geostructure stability and deformation. Settlement of foundations, fracture opening on slopes, roads, tunnel walls may be due to drying ... [more ▼]

Drying induced shrinkage of geomaterials may have a strong effect on geostructure stability and deformation. Settlement of foundations, fracture opening on slopes, roads, tunnel walls may be due to drying shrinkage. However, there is still a lack of knowledge concerning shrinkage evolution in time and shrinkage propagation within the material. In this study, the shrinkage of a specific clayey rock, Boom Clay, under drying conditions is experimentally investigated. This rock is a deep geological formation which is under study for high-level and long-life radioactive waste storage in Belgium. Two experimental campaigns are here presented. The first one, based on vapour equilibrium drying technique and completed by sample size manual measurement, aims to characterize the material shrinkage in balanced states. The second one, based on convective drying technique completed by shape monitoring using X-ray tomography, aims to analyse how shrinkage develops before reaching a steady state. Both approaches put in evidence the shrinkage anisotropy of this structurally bedded rock, with a ratio around 2 between the direction of maximum strains and the direction of minimum strains. However, the two drying techniques also provide complementary results, as the relation between the amount of shrinkage and the retention curve (for the uniform drying imposed with saline solutions) and the kinetics of shrinkage propagation inside the material (for the non-uniform drying imposed with air convection). [less ▲]

Detailed reference viewed: 107 (36 ULg)
Full Text
Peer Reviewed
See detailNoninvasive neurostimulation methods for migraine therapy: The available evidence
SCHOENEN, Jean ULg; Baschi, Roberta; MAGIS, Delphine ULg et al

in Cephalalgia : An International Journal of Headache (2016)

Abstract Background: Migraine is one of the most disabling neurological disorders. The current pharmacological armamentarium is not satisfying for a large proportion of patients because the responder rate ... [more ▼]

Abstract Background: Migraine is one of the most disabling neurological disorders. The current pharmacological armamentarium is not satisfying for a large proportion of patients because the responder rate does not exceed 50% on average and the most effective drugs often induce intolerable side effects. During recent years, noninvasive central and peripheral neuromodulation methods have been explored for migraine treatment. Overview: A review of the available evidence suggests that noninvasive neuromodulation techniques could be beneficial for migraine patients. The transcranial stimulation methods allow modulating selectively cortical activity and can thus be curtailed to the patient’s pathophysiological profile, while transcutaneous stimulation of pericranial nerves likely modulates central pain control centers. Occipital single-pulse transcranial magnetic stimulation and transcutaneous supraorbital stimulation have the strongest evidence respectively for acute and preventive treatment. Transcranial direct current stimulation and repetitive magnetic stimulation are promising in pilot studies, but large sham-controlled trials are not yet available. Conclusions: The noninvasive neurostimulation methods are promising for migraine treatment and devoid of serious adverse effects allowing their combination with drug therapies. Their application in clinical practice will depend on the industry’s capacity to develop portable and user-friendly devices, and on the scientists’ capacity to prove their efficacy in randomized sham-controlled trials. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailEditorial: Special issue on natural language processing and text analytics in industry
Ittoo, Ashwin ULg; Nguyen, Le Min; van den Bosch, Antal

in Computers in Industry (2016)

Detailed reference viewed: 58 (8 ULg)
Full Text
See detailVille et Université : l'expérience liégeoise
Frankignoulle, Pierre ULg

in Dérivations. Pour le débat urbain. (2016)

Detailed reference viewed: 17 (1 ULg)
Full Text
See detailLe Sart Tilman et les universités à l'heure de la "métapolisation"
Frankignoulle, Pierre ULg

in Dérivations. Pour le débat urbain. (2016), 2

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailPhenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity
Verstraelen,, Sandra; Peers, Bernard ULg; Maho, w et al

in Journal of Applied Toxicology (2016)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailProgressive Current Source Models in Magnetic Vector Potential Finite-Element Formulations
Dular, Patrick ULg; Kuo-Peng, Patrick; Ferreira da Luz, Mauricio V. et al

in IEEE Transactions on Magnetics (2016), 52(3),

Progressive refinements of the current sources in magnetic vector potential finite-element (FE) formulations are done with a subproblem method. The sources are first considered through magnetomotive force ... [more ▼]

Progressive refinements of the current sources in magnetic vector potential finite-element (FE) formulations are done with a subproblem method. The sources are first considered through magnetomotive force or Biot–Savart models up to their volume FE models, from statics to dynamics. A novel way to define the source fields is proposed to lighten the computational efforts, through the conversion of the common volume sources to surface sources, without the need for any preresolution. Accuracy improvements can then be obtained for local currents and fields, and global quantities, i.e., inductances, resistances, Joule losses, and forces. [less ▲]

Detailed reference viewed: 42 (2 ULg)
Full Text
Peer Reviewed
See detailTrois méthodes pédagogiques en formations médicale et pharmaceutique : L’APP, les Tests de Progression et les ECOS
Leclercq, Dieudonné ULg; Philippe, Geneviève; van der Vleuten, Cees

in Journal de Pharmacie Clinique (2016), 35(1), 7-22

During the four last decades, Higher Education has tried to re-equilibrate the ratio between the acquisition of knowledge and they development of competencies (being able to act efficiently and ethically ... [more ▼]

During the four last decades, Higher Education has tried to re-equilibrate the ratio between the acquisition of knowledge and they development of competencies (being able to act efficiently and ethically in complex situations). Pursuing this objective, in faculties of pharmacy and of medicine, a series of methods – audacious in their time- have been initiated. Three of them are described hereafter. For each of them, we will consider how their field implementation has evolved as well as validity and efficiency issues. The first one is The Problem Based Learning (PBL) approach, in which teaching is replaced by learning, i.e. in which students themselves, after having been motivated by a case presented b y a simulated patient, decide which contents to study and search, in an autonomous way, pieces of information in a huge “Study landscape” full of books and on the internet. In the second strategy, named “Progress Tests”, students have to pass, four times per year, a test on the medical knowledge that should be mastered by a general practitioner. Since during the 6 years of their medical studies he/she passes 24 (not identical but equivalent) tests, each student can observe his/her own progression. The third strategy deals both with training and with evaluation, and, as PBL, relies on role playing. It consists in students spending a few minutes (7 for instance) in various “stations” where they play the role of the professional (a pharmacist, a doctor) facing a concrete situation presented by a simulated patient. These three methods are described on the basis of their concrete implementation in two universities, the Maastricht and the Liège ones. An important common point they share is that they could be implemented thanks to the adoption of a program-referenced approach. This article presents these three educational strategies and the concepts that underpin them. [less ▲]

Detailed reference viewed: 47 (3 ULg)
Full Text
Peer Reviewed
See detailRelationships between population density, fine-scale genetic structure, mating system and pollen dispersal in a timber tree from African rainforests
Duminil, Jérôme; Daïnou, Kasso ULg; Kaviriri, D.K. et al

in Heredity (2016), 116

Owing to the reduction of population density and/or the environmental changes it induces, selective logging could affect the demography, reproductive biology and evolutionary potential of forest trees ... [more ▼]

Owing to the reduction of population density and/or the environmental changes it induces, selective logging could affect the demography, reproductive biology and evolutionary potential of forest trees. This is particularly relevant in tropical forests where natural population densities can be low and isolated trees may be subject to outcross pollen limitation and/or produce low-quality selfed seeds that exhibit inbreeding depression. Comparing reproductive biology processes and genetic diversity of populations at different densities can provide indirect evidence of the potential impacts of logging. Here, we analysed patterns of genetic diversity, mating system and gene flow in three Central African populations of the self-compatible legume timber species Erythrophleum suaveolens with contrasting densities (0.11, 0.68 and 1.72 adults per ha). The comparison of inbreeding levels among cohorts suggests that selfing is detrimental as inbred individuals are eliminated between seedling and adult stages. Levels of genetic diversity, selfing rates (∼16%) and patterns of spatial genetic structure (Sp ∼ 0.006) were similar in all three populations. However, the extent of gene dispersal differed markedly among populations: the average distance of pollen dispersal increased with decreasing density (from 200m in the high-density population to 1000m in the low-density one). Overall, our results suggest that the reproductive biology and genetic diversity of the species are not affected by current logging practices. However, further investigations need to be conducted in low-density populations to evaluate (1) whether pollen limitation may reduce seed production and (2) the regeneration potential of the species. [less ▲]

Detailed reference viewed: 22 (8 ULg)
Full Text
Peer Reviewed
See detailCollective vortex behaviors: diversity, proximate, and ultimate causes of circular animal group movements
Delcourt, Johann ULg; Bode, W.F. Nikolaï; Denoël, Mathieu ULg

in Quarterly Review of Biology (2016), 91(1), 1-24

Ant mill, caterpillar circle, bat doughnut, amphibian vortex, duck swirl, and fish torus are different names for rotating circular animal formations, where individuals turn around a common center. These ... [more ▼]

Ant mill, caterpillar circle, bat doughnut, amphibian vortex, duck swirl, and fish torus are different names for rotating circular animal formations, where individuals turn around a common center. These “collective vortex behaviors” occur at different group sizes from pairs to several million individuals and have been reported in a large number of organisms, from bacteria to vertebrates, including humans. However, to date, no comprehensive review and synthesis of the literature on vortex behaviors has been conducted. Here, we review the state of the art of the proximate and ultimate causes of vortex behaviors. The ubiquity of this behavioral phenomenon could suggest common causes or fundamental underlying principles across contexts. However, we find that a variety of proximate mechanisms give rise to vortex behaviors. We highlight the potential benefits of collective vortex behaviors to individuals involved in them. For example, in some species, vortices increase feeding efficiency and could give protection against predators. It has also been argued that vortices could improve collective decision making and information transfer. We highlight gaps in our understanding of these ubiquitous behavioral phenomena and discuss future directions for research in vortex studies. [less ▲]

Detailed reference viewed: 174 (24 ULg)
Full Text
Peer Reviewed
See detailInhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolismdependent manner
Bunik, Victoria; Mkrtchyan, Garait; Grabarska, Aneta et al

in Oncotarget (2016), 7(26400), 26421

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific ... [more ▼]

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific inhibition of OGDH by succinyl phosphonate (SP). SP action on different cancer cells was investigated using indicators of cellular viability and reactive oxygen species (ROS), metabolic profiling and transcriptomics. Relative sensitivity of various cancer cells to SP changed with increasing SP exposure and could differ in the ATP- and NAD(P)H-based assays. Glioblastoma responses to SP revealed metabolic sub-types increasing or decreasing cellular ATP/NAD(P)H ratio under OGDH inhibition. Cancer cell homeostasis was perturbed also when viability indicators were SPresistant, e.g. in U87 and N2A cells. The transcriptomics database analysis showed that the SP-sensitive cells, such as A549 and T98G, exhibit the lowest expression of OGDH compared to other TCA cycle enzymes, associated with higher expression of affiliated pathways utilizing 2-oxoglutarate. Metabolic profiling confirmed the dependence of cellular SP reactivity on cell-specific expression of the pathways. Thus, oxidative decarboxylation of 2-oxoglutarate is significant for the interdependent homeostasis of NAD(P)H, ATP, ROS and key metabolites in various cancer cells. Assessment of cellspecific responses to OGDH inhibition is of diagnostic value for anticancer strategies. [less ▲]

Detailed reference viewed: 21 (6 ULg)
Full Text
Peer Reviewed
See detailIncidence and risk factors for early renal dysfunction after liver transplantation.
WIESEN, Patricia ULg; MASSION, Paul ULg; JORIS, Jean ULg et al

in World journal of transplantation (2016), 6(1), 220-232

AIM: To determine renal dysfunction post liver transplantation, its incidence and risk factors in patients from a Belgian University Hospital. METHODS: Orthotopic liver transplantations performed from ... [more ▼]

AIM: To determine renal dysfunction post liver transplantation, its incidence and risk factors in patients from a Belgian University Hospital. METHODS: Orthotopic liver transplantations performed from January 2006 until September 2012 were retrospectively reviewed (n = 187). Patients with no renal replacement therapy (RRT) before transplantation were classified into four groups according to their highest creatinine plasma level during the first postoperative week. The first group had a peak creatinine level below 12 mg/L, the second group between 12 and 20 mg/L, the third group between 20 and 35 mg/L, and the fourth above 35 mg/L. In addition, patients who needed RRT during the first week after transplantation were also classified into the fourth group. Perioperative parameters were recorded as risk factors, namely age, sex, body mass index (BMI), length of preoperative hospital stay, prior bacterial infection within one month, preoperative ascites, preoperative treatment with beta-blocker, angiotensin-converting enzyme inhibitor or non steroidal anti-inflammatory drugs, preoperative creatinine and bilirubin levels, donor status (cardiac death or brain death), postoperative lactate level, need for intraoperative vasopressive drugs, surgical revision, mechanical ventilation for more than 24 h, postoperative bilirubin and transaminase peak levels, postoperative hemoglobin level, amount of perioperative blood transfusions and type of immunosuppression. Univariate and multivariate analysis were performed using logistic ordinal regression method. Post hoc analysis of the hemostatic agent used was also done. RESULTS: There were 78 patients in group 1 (41.7%), 46 in group 2 (24.6%), 38 in group 3 (20.3%) and 25 in group 4 (13.4%). Twenty patients required RRT: 13 (7%) during the first week after transplantation. Using univariate analysis, the severity of renal dysfunction was correlated with presence of ascites and prior bacterial infection, preoperative bilirubin, urea and creatinine level, need for surgical revision, use of vasopressor, postoperative mechanical ventilation, postoperative bilirubin and urea, aspartate aminotransferase (ASAT), and hemoglobin levels and the need for transfusion. The multivariate analysis showed that BMI (OR = 1.1, P = 0.004), preoperative creatinine level (OR = 11.1, P < 0.0001), use of vasopressor (OR = 3.31, P = 0.0002), maximal postoperative bilirubin level (OR = 1.44, P = 0.044) and minimal postoperative hemoglobin level (OR = 0.059, P = 0.0005) were independent predictors of early post-liver transplantation renal dysfunction. Neither donor status nor ASAT levels had significant impact on early postoperative renal dysfunction in multivariate analysis. Absence of renal dysfunction (group 1) was also predicted by the intraoperative hemostatic agent used, independently of the extent of bleeding and of the preoperative creatinine level. CONCLUSION: More than half of receivers experienced some degree of early renal dysfunction after liver transplantation. Main predictors were preoperative renal dysfunction, postoperative anemia and vasopressor requirement. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailGamma radiation induced modifications of tapioca starch
Atrous, Hager; Benbettaïeb, Nasreddine; Hosni, Faouzi et al

in Asian Academic Research Journal of Multidisciplinary (2016), 3(3), 187-220

The effect of gamma radiation (3, 5, 10, 20, 35 and 50 kGy) on the morphological, structural, physicochemical, pasting and thermal properties of tapioca starch was studied. Microphotographs of scanning ... [more ▼]

The effect of gamma radiation (3, 5, 10, 20, 35 and 50 kGy) on the morphological, structural, physicochemical, pasting and thermal properties of tapioca starch was studied. Microphotographs of scanning electron microscopy and polarized light microscopy revealed the absence of morphological changes induced by gamma radiation. The X-ray diffraction spectra showed that irradiation treatment did not influence the shape and intensity of X-ray diffraction peaks. The presence of free radicals in the irradiated tapioca starch was confirmed by electron spin resonance spectrometry. Fourier transform infrared spectroscopy showed that the irradiated starch displayed a significant decrease in the intensity of the O–H and C–H stretches, bending modes of water and glycosidic linkages. Irradiation improved the water solubility index of starch granules and depressed the apparent amylose content. An increase in the swelling power was observed after irradiation treatment until 20 kGy, followed by a decrease at higher doses. Brabender viscoamylograph test showed that the maximal consistency of the starch paste decreased significantly with increasing irradiation dose. There was no significant difference in the gelatinization temperatures, as well as the corresponding transition enthalpies among native and irradiated tapioca starch samples, as shown in the differential scanning calorimetry thermograms. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailFrémok: Comics Out-of-Bounds
Dejasse, Erwin ULg

in World Literature Today (2016), 90(2), 56-59

Article that analizes the history, background and publishing policity of French-Belgian publisher Frémok

Detailed reference viewed: 23 (3 ULg)
Full Text
Peer Reviewed
See detailText analytics in industry: Challenges, desiderata and trends
Ittoo, Ashwin ULg; Nguyen, Le Minh; van den Bosch, Antal

in Computers in Industry (2016), (78),

Detailed reference viewed: 45 (8 ULg)
Full Text
Peer Reviewed
See detailComparaison de l’impact du « VeinoPlus Sport » et du « TENS » sur la récupération de jeunes footballeurs amateurs
God, Maxime; LE GOFF, Caroline ULg; Evrard, Frédéric et al

in Journal de Traumatologie du Sport (2016), 33(1), 14-19

Aims The aim of this study was to evaluate the impact of “VeinoPlus Sport” on amateur soccer players’ recovery after an intense physical activity (2 drills). Method We proceeded to a comparative study ... [more ▼]

Aims The aim of this study was to evaluate the impact of “VeinoPlus Sport” on amateur soccer players’ recovery after an intense physical activity (2 drills). Method We proceeded to a comparative study between two devices: “VeinoPlus Sport” and “TENS” (used as a control system) on a population of 20 players (average age 17,1±0,8). Under identical conditions each player used the two devices during two separate sessions (called group “VeinoPlus Sport” and group “TENS”). The players performed an intense effort following the YoYo test concept. Four blood samples were taken from each participant and a Myotest evaluation was performed: one before the test, one just after the first intense effort, another after a short recovery time following the first effort, and the last one right after the second intense effort. For statistical analysis, we used the Anova algorithm of the “StatPlus” system and a Scheffé test. Results With both devices, we observed a significant elevation of lactate, HCO3− ions, and myoglobin as time progressed. The analysis of other blood parameters did not show any significant evolution in the course of the testing. The “VeinoPlus Sport” group, after the session, expressed feeling lighter and more fit than usual following an intense physical activity. They did not suffer any pain, tiredness, nor diminishment of strength. The same observation was made with the “TENS” group with the exception that some players felt a bit of soreness in their thigh and calf areas. In general, all participants admitted preferring the use of recovery machines instead of natural recovery. At the same time, none expressed any preferences between either of the devices. Conclusion The main asset of this study resided in the highlighting of minor differences as no way significant between the two machines tested on the chosen population. The “TENS” shows similar results as the “VeinoPlus Sport” even if a slight preference for the latter was expressed. Both devices permitted an equal or even better performance in the second drill in comparison to the first drill. [less ▲]

Detailed reference viewed: 42 (5 ULg)
Full Text
Peer Reviewed
See detailComparison of Nonlinear Domain Decomposition Schemes for Coupled Electromechanical Problems
Halbach, Alexandre ULg; Dular, Patrick ULg; Geuzaine, Christophe ULg

in IEEE Transactions on Magnetics (2016), 52(3),

The aim of this paper is to compare several domain decomposition schemes for nonlinear, coupled electromechanical problems. Both staggered and monolithic electrostatic/elastic formulations are considered ... [more ▼]

The aim of this paper is to compare several domain decomposition schemes for nonlinear, coupled electromechanical problems. Both staggered and monolithic electrostatic/elastic formulations are considered for the multiphysics problem. The domain decomposition is applied either to a single multiphysics iteration, which corresponds to a linear problem, or to the full nonlinear multiphysics resolution. In the latter, the problem solved at each domain decomposition iteration is nonlinear. The influence of the elastic wave’s frequency and the electrostatic potential on the convergence rate and the computational cost of the algorithm is investigated on a 2-D model of a vibrating micromembrane array. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailWeak magnetic field, solid-envelope rotation, and wave-induced N-enrichment in the SPB star zeta Cassiopeiae
Briquet, Maryline ULg; Neiner, C.; Petit, P. et al

in Astronomy and Astrophysics (2016), 587

Aims. The main-sequence B-type star zeta Cassiopeiae is known as a N-rich star with a magnetic field discovered with the Musicos spectropolarimeter. We model the magnetic field of the star by means of 82 ... [more ▼]

Aims. The main-sequence B-type star zeta Cassiopeiae is known as a N-rich star with a magnetic field discovered with the Musicos spectropolarimeter. We model the magnetic field of the star by means of 82 new spectropolarimetric observations of higher precision to investigate the field strength, topology, and effect. Methods. We gathered data with the Narval spectropolarimeter installed at Télescope Bernard Lyot (TBL; Pic du Midi, France) and applied the least-squares deconvolution technique to measure the circular polarisation of the light emitted from zeta Cas. We used a dipole oblique rotator model to determine the field configuration by fitting the longitudinal field measurements and by synthesizing the measured Stokes V profiles. We also made use of the Zeeman-Doppler imaging technique to map the stellar surface and to deduce the difference in rotation rate between the pole and equator. Results. zeta Cas exhibits a polar field strength B_pol of 100-150 G, which is the weakest polar field observed so far in a massive main-sequence star. Surface differential rotation is ruled out by our observations and the field of zeta Cas is strong enough to enforce rigid internal rotation in the radiative zone according to theory. Thus, the star rotates as a solid body in the envelope. Conclusions. We therefore exclude rotationally-induced mixing as the cause of the surface N-enrichment. We discuss that the transport of chemicals from the core to the surface by internal gravity waves is the most plausible explanation for the nitrogen overabundance at the surface of zeta Cas. [less ▲]

Detailed reference viewed: 35 (3 ULg)
Full Text
Peer Reviewed
See detailDesign Sensitivity Analysis for Shape Optimization of Nonlinear Magnetostatic Systems
Kuci, Erin ULg; Henrotte, François; Duysinx, Pierre ULg et al

in IEEE Transactions on Magnetics (2016), 52(3),

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative ... [more ▼]

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative concept of differential geometry where the flow is the velocity field associated with the modification of a geometrical parameter in the model. The resulting sensitivity formulas can be expressed naturally in a finite element setting through a volume integral in the layer of elements connected to the surface undergoing shape modification. The accuracy of the methodology is analyzed on a 2D model of an interior permanent magnet motor (IPM), and on a 3D model of a permanent magnet system. [less ▲]

Detailed reference viewed: 45 (11 ULg)
Full Text
Peer Reviewed
See detailL’entretien de tutorat documenté : un accompagnement réflexif ?
Alonso Vilches, Vincent ULg; Pirard, Florence ULg

in Education Permanente (2016), 206(1), 131-138

Notre contribution interroge l’activité tutorale dans un métier adressé à autrui, celui des professionnels de l’enfance. Elle souligne la complexité d’une telle activité dans un travail fondé sur des ... [more ▼]

Notre contribution interroge l’activité tutorale dans un métier adressé à autrui, celui des professionnels de l’enfance. Elle souligne la complexité d’une telle activité dans un travail fondé sur des référents multiples, qui nécessitent le développement d’une réflexivité sensible à la singularité des situations quotidiennes. Elle propose une analyse de moments d’entretien de tutorat accompagnés par un professionnel sur base d’une documentation vidéo. Elle montre que ces moments ne permettent pas forcément au stagiaire de développer une représentation signifiante de la situation ni d’en dégager les inférences nécessaires pour ajuster son action. [less ▲]

Detailed reference viewed: 56 (15 ULg)
Full Text
Peer Reviewed
See detailPeroxisomal microbodies are at the crossroads of acetate assimilation in the green microalga Chlamydomonas reinhardtii
Lauersen, Kyle J.; Willamme, Rémi ULg; Coosemans, Nadine ULg et al

in Algal Research (2016), 16

The glyoxylate cycle is essential for growth on C2 compounds such as acetate. In this investigation, for the first time, we have elucidated the subcellular localization of the enzymes of the glyoxylate ... [more ▼]

The glyoxylate cycle is essential for growth on C2 compounds such as acetate. In this investigation, for the first time, we have elucidated the subcellular localization of the enzymes of the glyoxylate cycle in the green microalga Chlamydomonas reinhardtii. Acetyl-CoA synthase and malate dehydrogenase exist as multiple isoforms in this microalga, therefore, we first identified those implicated in the glyoxylate cycle based on the observation that lack of isocitrate lyase (ICL) in a previously identified icl deficient mutantwas correlatedwith specific loss of the other enzymes of the glyoxylate cycle. In this work, we determined that five of the six enzymes associated with the glyoxylate cycle were found to be within peroxisomal microbodies. Citrate synthase, aconitase, malate synthase, malate dehydrogenase, and acetyl-CoA synthase are located in peroxisomal microbodies while isocitrate lyase is cytosolic. Our findings implicate a key role for these cellular compartments in acetate assimilation for Chlamydomonas.Microbodies have only recently been discovered in C. reinhardtii and their existence had been previously debated. The isoform specific subcellular localization determined here suggests that peroxisomal microbodies should be considered in the design of metabolic models for carbon assimilation in C. reinhardtii. [less ▲]

Detailed reference viewed: 36 (9 ULg)
Full Text
Peer Reviewed
See detailLe médicament du mois. Le dulaglutide (Trulicity®) : Nouvel agoniste des récepteurs du Glucagon-Like Peptide-1 en injection hebdomadaire pour traiter le diabète de type 2
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71

Summary : Dulaglutide (Trulicity®) is a new once-weekly agonist of Glucagon-Like Peptide-1 (GLP-1) receptors indicated in the treatment of type 2 diabetes. Phase III clinical trials in AWARD programme ... [more ▼]

Summary : Dulaglutide (Trulicity®) is a new once-weekly agonist of Glucagon-Like Peptide-1 (GLP-1) receptors indicated in the treatment of type 2 diabetes. Phase III clinical trials in AWARD programme demonstrated the efficacy and safety of dulaglutide in patients with type 2 diabetes treated by diet and exercise, metformin, a combination of metformin and a sulfonylurea or metformin and pioglitazone or even by supplements of prandial insulin. In the AWARD programme, dulaglutide (subcutaneous 0.75 or 1.5 mg once weekly) exerted a greater glucose-lowering activity than metformin, sitagliptin, exenatide or insulin glargine, and was non-inferior to liraglutide 1.8 mg once daily. Dulaglutide is currently reimbursed in Belgium after failure of and in combination with a dual oral therapy with metformin and a sulfonylurea or metformin and pioglitazone. [less ▲]

Detailed reference viewed: 58 (3 ULg)
Full Text
Peer Reviewed
See detailQuelle est la stratégie idéale pour traiter l’hyperglycémie du diabète de type 2 ?
SCHEEN, André ULg

in Médecine des Maladies Métaboliques (2016), 10(2), 91-93

Detailed reference viewed: 36 (1 ULg)
Full Text
Peer Reviewed
See detailL'échocardiographie en médecine équine: principe et interprétation des images.
Amory, Hélène ULg

in Nouveau Praticien Vétérinaire Equine (2016), 11(39), 55-60

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailA One-year Survey of Microsporum audouinii infections in Belgium: epidemiological and genotypic characterisation
SACHELI, Rosalie ULg; ADJETEY BAHUN, Akolé ULg; DARFOUF, Rajae ULg et al

in Clinical Microbiology and Infection (2016), 22(3), 2859-28517

During recent years the proportion of tinea capitis (TC) infections due to Microsporum audouinii (M. audouinii) has increased both in Belgium and other European countries. To better understand the ... [more ▼]

During recent years the proportion of tinea capitis (TC) infections due to Microsporum audouinii (M. audouinii) has increased both in Belgium and other European countries. To better understand the emergence of this species in the country, the Belgian National Reference Center (NRC) for dermatophytes launched an epidemiological survey on the main anthropophilic dermatophytes causing TC in Belgium and including the genomic characterization of M. audouinii isolates. In total, 116 strains of M. audouinii were confirmed and characterized by the DiversiLab® system (bioMérieux). Six genotypic variants were identified, among which one major group included 90 isolates and the reference strain. Another variant group (11 strains) was exclusively confined to a geographical region in South Belgium. Analysis of epidemiological characteristics of the infected population showed that the main age category concerned 5-9 year-old children with a sex ratio (Male/Female) of 1.97. Data concerning the geographic origin of the family revealed a majority of Belgian nationality (44.7%), suggesting that the contamination has originated in Belgium. Other nationalities primarily originated from Africa. At this time, no clear correlation has been established between one particular strain and a specific country of origin. [less ▲]

Detailed reference viewed: 59 (4 ULg)
Full Text
Peer Reviewed
See detailComputation of Source for Non-Meshed Coils in a Reduced Domain with A–V Formulation
Ferrouillat, Pauline; Guérin, Christophe; Meunier, Gérard et al

in IEEE Transactions on Magnetics (2016), 52(3),

The discretized source magnetic vector potential Aj, projected from source field Hs with H(curl,Ω) semi-norm, is studied for non-meshed coils with magnetic vector potential A and electric scalar potential ... [more ▼]

The discretized source magnetic vector potential Aj, projected from source field Hs with H(curl,Ω) semi-norm, is studied for non-meshed coils with magnetic vector potential A and electric scalar potential V formulation. As a novelty, source potential Aj is computed in a reduced domain Ωred instead of the complete domain Ω. For domains with fixed and moving parts, potential Aj can be computed on each part, for each of the related current sources, with no need to ensure its continuity between these parts. [less ▲]

Detailed reference viewed: 33 (4 ULg)
Full Text
Peer Reviewed
See detailTénotomie chez le veau
Djebala, Salem ULg; Sartelet, Arnaud ULg

in Point Vétérinaire (2016), 363

Detailed reference viewed: 35 (18 ULg)
Full Text
Peer Reviewed
See detailDecoding intracranial EEG data with multiple kernel learning method
Schrouff, Jessica ULg; Mourao-Miranda, Janaina; Phillips, Christophe ULg et al

in Journal of Neuroscience Methods (2016), 261

Machine learning models have been successfully applied to neuroimaging data to make predictions about behavioral and cognitive states of interest. While these multivariate methods have greatly advanced ... [more ▼]

Machine learning models have been successfully applied to neuroimaging data to make predictions about behavioral and cognitive states of interest. While these multivariate methods have greatly advanced the field of neuroimaging, their application to electrophysiological data has been less common especially in the analysis of human intracranial electroencephalography (iEEG, also known as electrocorticography or ECoG) data, which contains a rich spectrum of signals recorded from a relatively high number of recording sites. In the present work, we introduce a novel approach to determine the contribution of different bandwidths of EEG signal in different recording sites across different experimental conditions using the Multiple Kernel Learning (MKL) method. To validate and compare the usefulness of our approach, we applied this method to an ECoG dataset that was previously analysed and published with univariate methods. Our findings proved the usefulness of the MKL method in detecting changes in the power of various frequency bands during a given task and selecting automatically the most contributory signal in the most contributory site(s) of recording. With a single computation, the contribution of each frequency band in each recording site in the estimated multivariate model can be highlighted, which then allows formulation of hypotheses that can be tested a posteriori with univariate methods if needed. [less ▲]

Detailed reference viewed: 25 (3 ULg)
Full Text
Peer Reviewed
See detailUsing platelet-rich plasma to treat jumper’s knees: Exploring the effect of a second closely-timed infiltration
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Journal of Science and Medicine in Sport (2016), 19(3), 200-204

Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove ... [more ▼]

Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of two or three successive infiltrations. The aim of this study was to evaluate whether two infiltrations of PRP proves more effective than a single treatment. DESIGN: Prospective, randomized and comparative study of level 2. METHODS: Twenty patients suffering from chronic proximal patellar tendinopathy were enrolled into the study and split into two randomized groups (one or two infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. RESULTS: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. CONCLUSIONS: The comparison between one or two infiltrations of PRP did not reveal any difference between the two groups at short to mid term. A second closely-timed infiltration of PRP to treat proximal patellar tendinopathies is not necessary to improve the efficacy of this treatment in the short term. [less ▲]

Detailed reference viewed: 93 (30 ULg)
Full Text
See detailAdolescence, et "double identité". Quand l’engagement radical violent devient une réponse à un questionnement identitaire
Garcet, Serge ULg

in L'Observatoire (2016), 86

L’engagement radical violent est caractérisé par la jeunesse de ses participants. Il apparaît comme une réponse individuelle à un questionnement identitaire dans lequel des processus cognitifs ... [more ▼]

L’engagement radical violent est caractérisé par la jeunesse de ses participants. Il apparaît comme une réponse individuelle à un questionnement identitaire dans lequel des processus cognitifs caractéristiques de l’adolescence sont associés aux représentations qu’engendre la problématique de la « double identité » chez les jeunes issus de l’immigration. L’article tente de décrire ce processus du point de vue psychologique tout en relevant le rôle déterminant tenu par les cognitions et les émotions sur l’adoption d’une posture victimaire derrière l’engagement radical. [less ▲]

Detailed reference viewed: 84 (21 ULg)
Full Text
Peer Reviewed
See detailActive Management of Low-Voltage Networks for Mitigating Overvoltages due to Photovoltaic Units
Olivier, Frédéric ULg; Aristidou, Petros ULg; Ernst, Damien ULg et al

in IEEE Transactions on Smart Grid (2016), 2(7), 926-936

In this paper, the overvoltage problems that might arise from the integration of photovoltaic panels into low-voltage distribution networks is addressed. A distributed scheme is proposed that adjusts the ... [more ▼]

In this paper, the overvoltage problems that might arise from the integration of photovoltaic panels into low-voltage distribution networks is addressed. A distributed scheme is proposed that adjusts the reactive and active power output of inverters to prevent or alleviate such problems. The proposed scheme is model-free and makes use of limited communication between the controllers, in the form of a distress signal, only during emergency conditions. It prioritizes the use of reactive power, while active power curtailment is performed only as a last resort. The behavior of the scheme is studied using dynamic simulations on a single low-voltage feeder and on a larger network composed of 14 low-voltage feeders. Its performance is compared to a centralized scheme based on the solution of an Optimal Power Flow problem, whose objective function is to minimize the active power curtailment. The proposed scheme successfully mitigates overvoltage situations due to high photovoltaic penetration and performs almost as well as the Optimal Power Flow based solution with significantly less information and communication requirements. [less ▲]

Detailed reference viewed: 796 (129 ULg)
Full Text
Peer Reviewed
See detailReduced Order Model for Accounting for High Frequency Effects in Power Electronic Components
Paquay, Yannick ULg; Geuzaine, Christophe ULg; Hasan, Md. Rokibul et al

in IEEE Transactions on Magnetics (2016)

Detailed reference viewed: 58 (12 ULg)