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See detailLa place des savoirs grammaticaux et lexicaux dans les référentiels de compétences (1999-2016) et dans certains manuels de langues modernes
Simons, Germain ULiege; Delbrassine, Daniel ULiege; Van Hoof, Florence ULiege et al

in Didactiques en pratique (2017), 3

Cet article propose d'abord une lecture critique des référentiels de langues modernes qui ont été en vigueur en Communauté française de Belgique entre 1999 et 2016. Y sont principalement analysés les ... [more ▼]

Cet article propose d'abord une lecture critique des référentiels de langues modernes qui ont été en vigueur en Communauté française de Belgique entre 1999 et 2016. Y sont principalement analysés les référentiels "Socles de compétences en langues modernes" et "Compétences terminales et savoirs requis en langues modernes". La deuxième partie de l'article porte sur l'analyse partielle de deux manuels, le "Nieuwe Tandem 2" et le "New Headway". Une des thèses des auteurs de l'article est que ces référentiels de compétences et ces supports didactiques peuvent accroître l'hétérogénéité des niveaux de maîtrise en langue et générer des inégalités dans l'apprentissage. L'article se termine en évoquant différentes pistes qui peuvent contribuer à limiter les risques identifiés. [less ▲]

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See detailA fast and simple method for simultaneous measurements of 25(OH)D, 24,25(OH)2D and the Vitamin D Metabolite Ratio (VMR) in serum samples by LC-MS/MS
Fabregat Cabello, Neus ULiege; Farre Segura, Jordi ULiege; Huyghebaert, Loreen ULiege et al

in Clinica Chimica Acta (2017)

BACKGROUND: Rapid, easy and reliable measurement of the major vitamin D metabolites is required in order to fulfill the needs of a clinical routine laboratory. To overcome these challenges, we have ... [more ▼]

BACKGROUND: Rapid, easy and reliable measurement of the major vitamin D metabolites is required in order to fulfill the needs of a clinical routine laboratory. To overcome these challenges, we have developed and validated a LC-MS/MS method for the quantification of 25-hydroxyvitamin D2 and D3, epi-25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. METHODS: Sample preparation was based on precipitation and centrifugation of 100 µL of patient serum, followed by injection into the LC-MS/MS system. Samples from Vitamin D Standardization Program (n=80) and patient samples (n=281) have been compared with a reference LC-MS/MS method. For the analytical validation NIST and Labquality quality control materials were used. RESULTS: Mean intra-assay and inter-assay imprecision were less than 6.0 and 6.4% and mean recoveries were within 95-104%. LOQ’s were 0.5 µg/L for 24,25(OH)2D3, 1.1 µg/L for 25(OH)D3 and epi-25(OH)D3 and 1.7 µg/L for 25(OH)D2. A 3% bias obtained between the proposed and the reference method satisfies Vitamin D Standardization Program recommendations. CONCLUSIONS: We present a rapid, easy, reliable and cost-effective method completely adequate for routine testing, which permits the measurement of the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D, Vitamin D Metabolite Ratio (VMR), in serum samples. [less ▲]

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See detailContemporary groups in the genetic evaluation of Nellore cattle using Bayesian inference
Alves da Silva, Delvan; Fonseca e Silva, Fabyano; Torres Ventura, Henrique et al

in Pesquisa Agropecuária Brasileira (2017), 52(8), 643-651

The objective of this work was to evaluate the criteria for the formation of contemporary groups (CGs) in the genetic evaluation of body weight at weaning in Nellore cattle. A total of 713,474 records ... [more ▼]

The objective of this work was to evaluate the criteria for the formation of contemporary groups (CGs) in the genetic evaluation of body weight at weaning in Nellore cattle. A total of 713,474 records from 3,066 herds located in Midwestern and Northern Brazil were used. Data were obtained from the genealogical registry of zebu breeds of the Brazilian association of zebu breeders. Data structures were defined based on the number of standard deviations (SDs) for outlier removal (±2.0, ±2.5, ±3.0, and ±3.5) and on the minimal number of animals per CG (3, 7, and 15). Genetic evaluation was performed with an animal model using Bayesian inference. Data structures with ±3.5 SDs and CG with at least 15 animals presented the highest additive genetic variance (82.65±2.93), and those with ±2.0 SDs and CG with at least 3 animals showed the lowest one (60.23±1.96). The proper formation of CGs results in better-quality data archives, allowing to obtain more trustable estimates for the genetic parameters. Better selection responses are obtained when the following criteria are adopted for the removal of outliers: 2.5, 3.0, and 3.5 standard deviations and a minimum of 15 animals per contemporary group. [less ▲]

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See detailSimilarity of the Jovian satellite footprints: spots multiplicity and dynamics
Bonfond, Bertrand ULiege; Grodent, Denis ULiege; Badman, S. V. et al

in Icarus (2017), 292(2017), 208217

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the ... [more ▼]

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the planet. Called satellite footprints, these auroral features appear either as a single spot (Europa and Enceladus) or as multiple spots (Io and Ganymede). Moreover, they can be followed by extended trailing tails in the case of Io and Europa, while no tail has been reported for Ganymede and Enceladus, yet. Here we show that all Jovian footprints can be made of several spots. Furthermore, the footprints all experience brightness variations on timescale of 2-3 minutes. We also demonstrate that the satellite location relative to the plasma sheet is not the only driver for the footprint brightness, but that the plasma environment and the magnetic field strength also play a role. These new findings demonstrate that the Europa and Ganymede footprints are very similar to the Io footprint. As a consequence, the processes expected to take place at Io, such as the bi-directional electron acceleration by Alfvén waves or the partial reflection of these waves on plasma density gradients, can most likely be extended to the other footprints, suggesting that they are indeed universal processes. [less ▲]

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See detail« Oser sauver à l’école » : Mise en place d’un cycle de premier secours au cours d’éducation physique
Collin, Manon ULiege; Cloes, Marc ULiege; Laurent, Charlotte et al

in Didactiques en Pratique (2017), 3

En Europe et aux États-Unis, plus de 700 000 personnes décèdent chaque année des suites d’un arrêt cardiaque (Berdowski et al. 2010). Avec un taux de survie de 2 à 10 % (European Resuscitation Council ... [more ▼]

En Europe et aux États-Unis, plus de 700 000 personnes décèdent chaque année des suites d’un arrêt cardiaque (Berdowski et al. 2010). Avec un taux de survie de 2 à 10 % (European Resuscitation Council, 2015), le pronostic vital associé aux arrêts cardiaques est, dès lors, relativement limité. Celui-ci peut être cinq à sept fois supérieur si un témoin pratique une réanimation cardio-pulmonaire (RCP) et une défibrillation durant les premières minutes d’intervention (ERC, 2015). Dans le cadre de cette étude pilote, l’objectif était d’analyser la pertinence, l’impact et la faisabilité de la mise en place d’un cycle de premiers secours dans un contexte scolaire, et, plus particulièrement, dans le programme du cours d’éducation physique. Le cycle, d'une durée de 6 semaines (6 x 50 minutes), a été dispensé à deux classes de rhétoriques (n=51). Les compétences des élèves ont été évaluées à l'aide d'un questionnaire avant et après le cycle, ainsi qu'une grille d'observation évaluant les habiletés gestuelles des élèves lors d'un protocole complet de réanimation de base d’une personne adulte avec un DEA. La moyenne des résultats des élèves au questionnaire est passée de 6,12 ± 3,25/20 (0,5-14) lors du pré-test à 17,32 ± 1,79 /20 (10,5-20) à l’issue du cycle (p=0,00). La moyenne au test pratique est de 17,16 ± 1,72/20 (13,66-20). La séquence de cours proposée a permis d’améliorer les connaissances théoriques des élèves, leurs habiletés gestuelles et leur confiance par rapport à leur capacité à porter secours à une victime d’un arrêt cardiaque, et s'inscrit clairement dans la philosophie du Pacte pour un Enseignement d’Excellence. [less ▲]

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See detailChemical abundances of fast-rotating massive stars. II. Interpretation and comparison with evolutionary models
Cazorla, Constantin ULiege; Nazé, Yaël ULiege; Morel, Thierry ULiege et al

in Astronomy and Astrophysics (2017), 604(A123),

Aims: Past observations of fast-rotating massive stars exhibiting normal nitrogen abundances at their surface have raised questions about the rotational mixing paradigm. We revisit this question thanks to ... [more ▼]

Aims: Past observations of fast-rotating massive stars exhibiting normal nitrogen abundances at their surface have raised questions about the rotational mixing paradigm. We revisit this question thanks to a spectroscopic analysis of a sample of bright fast-rotating OB stars, with the goal of quantifying the efficiency of rotational mixing at high rotation rates. Methods: Our sample consists of 40 fast rotators on the main sequence, with spectral types comprised between B0.5 and O4. We compare the abundances of some key element indicators of mixing (He, CNO) with the predictions of evolutionary models for single objects and for stars in interacting binary systems. Results: The properties of half of the sample stars can be reproduced by single evolutionary models, even in the case of probable or confirmed binaries that can therefore be true single stars in a pre-interaction configuration. The main problem for the rest of the sample is a mismatch for the [N/O] abundance ratio (we confirm the existence of fast rotators with a lack of nitrogen enrichment) and/or a high helium abundance that cannot be accounted for by models. Modifying the diffusion coefficient implemented in single- star models does not solve the problem as it cannot simultaneously reproduce the helium abundances and [N/O] abundance ratios of our targets. Since part of them actually are binaries, we also compared their chemical properties with predictions for post-mass transfer systems. We found that these models can explain the abundances measured for a majority of our targets, including some of the most helium-enriched, but fail to reproduce them in other cases. Our study thus reveals that some physical ingredients are still missing in current models. [less ▲]

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See detailLe flâneur et l'ethnographe. Sur le savoir des Physiologies
Stienon, Valérie ULiege

in La Licorne (2017)

Les Physiologies parues dans la première moitié du XIXe siècle dans la presse satirique illustrée et les collections des éditeurs de pittoresques livrent un certain savoir sur la société parisienne de la ... [more ▼]

Les Physiologies parues dans la première moitié du XIXe siècle dans la presse satirique illustrée et les collections des éditeurs de pittoresques livrent un certain savoir sur la société parisienne de la Monarchie de Juillet. Elles le font en situant les contemporains dans leur biotope métropolitain et en pratiquant des formes de microsociologie par consignation des us et coutumes saisis à travers le prisme de l’observation quotidienne in situ. De ce point de vue, ces textes semblent proches de documents d’ethnographie critique, si on conçoit l’ethnographie comme la discipline qui s’occupe de la collecte sur le terrain de données anthropologiques et sociales. Ce geste ethnographique a pu être préparé par la rencontre du regard du clinicien sur le social et du réflexe classificateur du naturaliste auxquels s’ajoutent des données factuelles historiques : l’anthropologie française se développe à Paris dès 1799, suite à la découverte de l’enfant sauvage de l’Aveyron, avec la Société des observateurs de l’homme. Si celle-ci est dissoute très tôt, en 1804, d’autres groupements prennent le relais et, en 1839, la Société ethnologique est créée à Paris. Revenant sur le contexte qui prépare la naissance des disciplines ethnologique et sociologique, cette étude propose de croiser les scénographies énonciatives de l’ethnographe mises en œuvre dans les Physiologies à une autre figure du savoir en déambulation qu’elles thématisent abondamment, celle du flâneur, pour déterminer leurs généalogies littéraires et leurs apports respectifs au savoir (pré)sociologique manifesté par ces textes dans leur poétique d’écriture situable entre presse engagée, littérature et sciences du vivant. [less ▲]

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See detailAnalysis of the non-Markovianity for electron transfer reactions in the oligothiophene-fullerene in an heterojunction
Mangaud, Etienne; Meier, Christoph; Desouter, Michèle ULiege

in Chemical Physics (2017), 494

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See detailCombining semi-automated image analysis techniques with machine learning algorithms to accelerate large scale genetic studies
Atkinson, Jonathan; Lobet, Guillaume; Noll, Manuel ULiege et al

in GigaScience (2017)

Background: Genetic analyses of plant root systems require large datasets of extracted architectural traits. To quantify such traits from images of root systems, researchers often have to choose between ... [more ▼]

Background: Genetic analyses of plant root systems require large datasets of extracted architectural traits. To quantify such traits from images of root systems, researchers often have to choose between automated tools (that are prone to error and extract only a limited number of architectural traits) or semi-automated ones (that are highly time consuming). Findings: We trained a Random Forest algorithm to infer architectural traits from automatically extracted image descriptors. The training was performed on a subset of the dataset, then applied to its entirety. This strategy allowed us to (i) decrease the image analysis time by 73% and (ii) extract meaningful architectural traits based on image descriptors. We also show that these traits are sufficient to identify Quantitative Trait Loci that had previously been discovered using a semi-automated method. Conclusions: We have shown that combining semi-automated image analysis with machine learning algorithms has the power to increase the throughput of large scale root studies. We expect that such an approach will enable the quantification of more complex root systems for genetic studies. We also believe that our approach could be extended to other areas of plant phenotyping. [less ▲]

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See detailCan electoral inequalities be legally justified?
Bouhon, Frédéric ULiege

in European Review of Public Law (2017), 2016(Automn), 839-879

In light of the principle of equality, German, Belgian and British election law contain some legal rules that tend to distribute the faculty to influence the composition of the elected assemblies equally ... [more ▼]

In light of the principle of equality, German, Belgian and British election law contain some legal rules that tend to distribute the faculty to influence the composition of the elected assemblies equally among the governed people, and others that tend to distribute it unequally. The inequality caused by the latter group may be to some extent legally justified by concerns for the general interest, but also provides rulers with means that help them to remain in power, which is hardly justifiable from a legal perspective. In these legal systems, parties are expected to gain a significant portion of the people’s support: not only should the parliament (as a whole) and its members (as individuals) represent the governed people, but the parties themselves are expected to be sufficiently representative of the people in order to access the legislative assemblies. Notably, this thesis draws examples from the case law of the European Court of Human Rights, from which relevant decisions are mentioned here. [less ▲]

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See detailInnovative polyelectrolytes/poly(ionic liquid)s for energy and environment
Ajjan, Fátima N.; Ambrogi, Martina; Tiruye, Girum Ayalneh et al

in Polymer International (2017), 66(8), 1119-1126

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications ... [more ▼]

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications. Within the project different types of innovative polyelectrolytes were synthesized such as poly(ionic liquid)s coming from renewable or natural ions, thiazolium cations, cathechol functionalities or from a new generation of cheap deep-eutectic monomers. Further, macromolecular architectures such as new poly(ionic liquid) block copolymers and new (semi)conducting polymer/polyelectrolyte complexes were also developed. As the final goal, the application of these innovative polymers in energy and environment was investigated. Important advances in energy storage technologies included the development of new carbonaceous materials, new lignin/conducting polymer biopolymer electrodes, new iongels and single-ion conducting polymer electrolytes for supercapacitors and batteries and new poly(ionic liquid) binders for batteries. On the other hand, the use of the innovative polyelectrolytes into sustainable environmental technologies led to the development of new liquid and dry water, new materials for water cleaning technologies such as floculants, oil absorbers, new recyclable organocatalysts platform and multifunctional polymer coatings with antifouling and antimicrobial properties. All in all this article demonstrates the potential of the poly(ionic liquid)s for high-value applications in Energy & Enviromental areas. [less ▲]

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See detailComprehensive study of the drying behavior of Boom clay:Experimental investigation and numerical modeling
Hubert, Julien ULiege; Plougonven, Erwan ULiege; Prime, Noémie et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2017)

This paper presents a thermo-hydro-mechanical framework to model the dryingbehavior of Boom clay. First, the experimental campaign conducted Noémie Primeis briefly presented because it is used to validate ... [more ▼]

This paper presents a thermo-hydro-mechanical framework to model the dryingbehavior of Boom clay. First, the experimental campaign conducted Noémie Primeis briefly presented because it is used to validate the model. The data acquisitionand processing is emphasized because of the use of X-ray microtomography to beable to more accurately compare experimental and numerical strain fields. The dif-ferent submodels are introduced. Numerical simulations are performed to illustratethe capability of the proposed model to reproduce the observed behavior. Finally,a comprehensive sensitivity study on several key model parameters associated withthe water retention curve, and the permeability of the medium, is performed to get abetter understanding of the physics behind the coupled model. [less ▲]

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See detailAssessment of Continuous Pain in Newborns admitted to NICUs in 18 European Countries
Anand, Kanwaljeet; Eriksson, Mats; Boyle, Elaine et al

in Acta Paediatrica (2017), 106(8), 1248-59

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A ... [more ▼]

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A prospective cohort study in 243 Neonatal Intensive Care Units (NICUs) from 18 European countries recorded frequency of pain assessments, use of mechanical ventilation, sedation, analgesia, or neuromuscular blockade for each neonate upto 28 days after NICU admission. Results: Only 2113/6648 (31·8%) of neonates received assessments of continuous pain, occurring variably among tracheal ventilation (TrV, 46·0%), noninvasive ventilation (NiV, 35· 0%), and no ventilation (NoV, 20· 1%) groups (p<0· 001). Daily assessments for continuous pain occurred in only 10·4% of all neonates (TrV: 14· 0%, NiV: 10· 7%, NoV: 7· 6%; p<0· 001). More frequent assessments of continuous pain occurred in NICUs with pain guidelines, nursing champions, and surgical admissions prompted (all p<0·01), and for newborns <32 weeks gestational age, those requiring ventilation, or opioids, sedatives-hypnotics, general anesthetics (O-SH-GA) (all p<0·001), or surgery (p=0· 028). Use of O-SH-GA drugs increased the odds for pain assessment in the TrV (OR:1· 60, p<0·001) and NiV groups (OR:1·40, p<0· 001). Conclusion: Assessments of continuous pain occurred in less than one-third of NICU admissions, and daily in only 10% of neonates. NICU clinical practices should consider including routine assessments of continuous pain in newborns. [less ▲]

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See detailLa difficile jointure des directives EU anti-BEPS et des traités fiscaux
Docclo, Caroline ULiege

in Fiscologue International = Fiscoloog internationaal (2017)

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See detailCation Distribution Dependent Magnetic Properties in CoCr 2-x Fe x O 4 (x= 0.1 to 0.5): EXAFS, Mӧssbauer and Magnetic Measurements
Kumar, Durgesh; Banerjee, Alok; Mahmoud, Abdelfattah ULiege et al

in Dalton Transactions (2017), 46

In this report, we have examined the evolution of the structure and rich magnetic transitions such as a paramagnetic to ferrimagnetic phase transition at the Curie temperature (TC), spiral ordering ... [more ▼]

In this report, we have examined the evolution of the structure and rich magnetic transitions such as a paramagnetic to ferrimagnetic phase transition at the Curie temperature (TC), spiral ordering temperature (TS) and lock-in temperature (TL) observed in the CoCr2O4 spinel multiferroic after substituting Fe. The crystal structure, microstructure and cation distribution among the tetrahedral (A) and octahedral (B) sites in the spinel lattice are characterised by X-ray diffraction, transmission electron microscopy, Extended X-ray Absorption Fine Structure (EXAFS) and Mössbauer spectroscopy. Due to the same radial distances of the first coordination shell in both tetrahedral and octahedral environments observed in EXAFS spectra, the position of the second coordination shell specifies the preference of more Fe ions towards the A site at x = 0.1. At x = 0.5, more Fe ions favour the B site. The cation distribution quantitatively obtained from the Mössbauer spectral analysis shows that while 60% of Fe ions occupy the A site in x = 0.1, 40% occupy it in x = 0.5. Surprisingly at x = 0.3, Fe ions are distributed equally among the A and B sites. dc magnetization reveals an increase in TC from 102 K to 200 K and in TS from 26 to 40 K with an increase in Fe concentration, indicating an enhancement in A–B exchange interaction at the expense of B–B. No report has until now demonstrated such an enhancement in TS either in pure or in doped CoCr2O4. Furthermore, frequency-dependent ac susceptibility (χ) data fitted with different phenomenological models such as the Néel–Arrhenius, Vogel–Fulcher and power law confirm a spin-glass and/or cluster-glass behaviour in nanoparticles of CoCr2−xFexO4. [less ▲]

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See detailLe maraîchage périurbain à Libreville et Owendo (Gabon) : pratiques culturales et durabilité
Bayendi-Loudit, Sandrine ULiege; Ndoutoume Ndong, Auguste; Francis, Frédéric ULiege

in Cahiers Agricultures (2017)

In Gabon, peri-urban gardening is an opportunity to provide vegetables to the main cities, such as Libreville and Owendo. Following a survey conducted in three market gardening areas, an inventory was ... [more ▼]

In Gabon, peri-urban gardening is an opportunity to provide vegetables to the main cities, such as Libreville and Owendo. Following a survey conducted in three market gardening areas, an inventory was conducted on the socio-economic characteristics, the diversity of crops, and pesticide uses. The cropped areas range from 0.08 ha to 0.4 ha per farmer, according to the site. National operators represent 51%, while people from Burkina Faso manage 40% of vegetable production. The most cultivated species throughout the year are amaranth (Amaranthus hybridus L.), lettuce (Lactuca sativa L.), Guinea sorrel (Hibiscus sabdariffa L.) and black nightshade (Solanum nigrum L.). The most important pests are Aphididae and some beetles. The most commonly used plant protection products are insecticides, mainly conventional neurotoxic. Best crop monitoring, pest control including pesticide application reduction, and the possibility to offer microcredit systems to small producers would help increasing peri-urban healthy vegetable production and increase local food autonomy [less ▲]

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See detailSynthesis and complexation of superbulky imidazolium-2-dithiocarboxylate ligands
Beltran Alvarez, Tomás Francisco ULiege; Zaragoza, Guillermo; Delaude, Lionel ULiege

in Dalton Transactions (Cambridge, England : 2003) (2017), 46(28), 9036-9048

The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the ... [more ▼]

The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the corresponding imidazolium-2-dithiocarboxylate zwitterions in high yields. These new dithiolate ligands were fully characterized and their coordination chemistry toward common Re(i) and Ru(ii) metal sources was thoroughly investigated. Neutral [ReBr(CO)3(S2C[middle dot]NHC)] chelates featured three facially-arranged carbonyl groups on a distorted octahedron, whereas cationic [RuCl(p-cymene)(S2C[middle dot]NHC)]PF6 complexes displayed a piano-stool geometry. The molecular structures of the six new compounds revealed that the NHC[middle dot]CS2 inner salts were highly flexible. Indeed, the torsion angle between their anionic and cationic moieties varied between ca. 63[degree] in the free ligands and 3[degree] in the ruthenium complexes. Concomitantly, the S-C-S bite angle underwent a contraction from 131[degree] to 110-113[degree] upon chelation. Computation of the %VBur parameter showed that the dithiocarboxylate unit of the NHC[middle dot]CS2 betaines chiefly determined the steric requirements of the imidazolium moieties, irrespective of the metal center involved in the complexation. The replacement of the p-methyl substituents of IDip*Me with p-methoxy groups in IDip*OMe did not significantly affect the ligand bulkiness. The more electron-donating methoxy group led, however, to small changes in various IR wavenumbers used to probe the electron donor properties of the carbene moiety. [less ▲]

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See detailSpray-drying as a tool to disperse conductive carbon inside Na2FePO4F particles by addition of carbon black or carbon nanotubes to the precursor solution
Mahmoud, Abdelfattah ULiege; Caes, Sebastien; Brisbois, Magali et al

in Journal of Solid State Electrochemistry (2017)

In this work, Na2FePO4F-carbon composite powders were prepared by spray-drying a solution of inorganic precursors with 10 and 20 wt% added carbon black (CB) or carbon nanotubes (CNTs). In order to compare ... [more ▼]

In this work, Na2FePO4F-carbon composite powders were prepared by spray-drying a solution of inorganic precursors with 10 and 20 wt% added carbon black (CB) or carbon nanotubes (CNTs). In order to compare the effect of CB and CNTwhen added to the precursor solutions, the structural, electrochemical, and morphological properties of the synthesized Na2FePO4F-xCB and Na2FePO4F-xCNT samples were systematically investigated. In both cases, X-ray diffraction shows that calcination at 600 °C in argon leads to the formation of Na2FePO4F as the major inorganic phase. 57Fe Mössbauer spectroscopy was used as complementary technique to probe the oxidation states, local environment, and identify the composition of the iron-containing phases. The electrochemical performance is markedly better in the case of Na2FePO4F-CNT (20 wt%), with specific capacities of about 100 mAh/g (Na2FePO4F-CNT) at C/4 rate vs. 50 mAh/g for Na2FePO4F-CB (20 wt%). SEM characterization of Na2FePO4F-CB particles revealed different particle morphologies for the Na2FePO4F-CNT and Na2FePO4F-CB powders. The carbon-poor surface observed for Na2FePO4FCB could be due to a slow diffusion of carbon in the droplets during drying. On the contrary, Na2FePO4F-CNT shows a better CNT dispersion inside and at the surface of the NFPF particles that improves the electrochemical performance. [less ▲]

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See detailOccupational social and mental stimulation and cognitive decline with advancing age
Grotz, Catherine ULiege; Meillon, Céline; Amieva, Hélène et al

in Age and Ageing (2017)

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See detailIs supercritical fluid chromatography hyphenated to massspectrometry suitable for the quality control of vitamin D3 oilyformulations?
Andri, Bertyl ULiege; Dispas, Amandine ULiege; Klinkenberg, Régis et al

in Journal of Chromatography. A (2017), 1515

Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a ... [more ▼]

Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a goodalternative over Normal Phase Liquid Chromatography (NPLC). Indeed, modern SFC separations arefast, efficient with suitable quantitative performances. Moreover, the hyphenation of SFC to mass spec-trometry (MS) provides additional gains in specificity and sensitivity. The present work aims at thedetermination of vitamin D3 by SFC-MS for routine Quality Control (QC) of medicines specifically. Basedon the chromatographic parameters previously defined in SFC-UV by Design of Experiments (DoE) andDesign Space methodology, the method was adapted to work under isopycnic conditions ensuring a base-line separation of the compounds. Afterwards, the response provided by the MS detector was optimizedby means of DoE methodology associated to desirability functions. Using these optimal MS parameters,quantitative performances of the SFC-MS method were challenged by means of total error approachmethod validation. The resulting accuracy profile demonstrated the full validity of the SFC-MS method. It was indeed possible to meet the specification established by the European Medicines Agency (EMA) (i.e. 95.0 − 105.0% of the API content) for a dosing range corresponding to at least 70.0-130.0% of theAPI content. These results highlight the possibility to use SFC-MS for the QC of medicine and obviouslysupport the switch to greener analytical methods. [less ▲]

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See detailDeep imaging search for planets forming in the TW Hya protoplanetary disk with the Keck/NIRC2 vortex coronagraph
Ruane, G.; Mawet, D.; Kastner, J. et al

in Astronomical Journal (The) (2017), 154

Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic ... [more ▼]

Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic imaging observations to search for accreting planets especially within dust gaps previously detected in scattered light and submm-wave thermal emission. Three nights of observations with the Keck/NIRC2 vortex coronagraph in $L^\prime$ (3.4-4.1$\mu$m) did not reveal any statistically significant point sources. We thereby set strict upper limits on the masses of non-accreting planets. In the four most prominent disk gaps at 24, 41, 47, and 88 au, we obtain upper mass limits of 1.6-2.3, 1.1-1.6, 1.1-1.5, and 1.0-1.2 Jupiter masses ($M_J$) assuming an age range of 7-10 Myr for TW Hya. These limits correspond to the contrast at 95\% completeness (true positive fraction of 0.95) with a 1\% chance of a false positive within $1^{\prime\prime}$ of the star. We also approximate an upper limit on the product of planet mass and planetary accretion rate of $M_p\dot{M}\lesssim10^{-8} M_J^2/yr$ implying that any putative $\sim0.1 M_J$ planet, which could be responsible for opening the 24 au gap, is presently accreting at rates insufficient to build up a Jupiter mass within TW Hya's pre-main sequence lifetime. [less ▲]

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See detailMapping the dependency of crops on pollinators in Belgium
Jacquemin, Floriane ULiege; Violle, Cyrille; Rasmont, Pierre et al

in One Ecosystem (2017)

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See detailEvaluating model simulations of 20th century sea-level rise. Part 1: Global mean sea-level change
Slangen, A.; Meyssignac, B.; Agosta, Cécile ULiege et al

in Journal of Climate (2017)

Sea-level change is one of the major consequences of climate change and is projected to affect coastal communities around the world. Here, we compare Global Mean Sea-Level (GMSL) change estimated by 12 ... [more ▼]

Sea-level change is one of the major consequences of climate change and is projected to affect coastal communities around the world. Here, we compare Global Mean Sea-Level (GMSL) change estimated by 12 climate models from the 5th phase of the World Climate Research Programme’s Climate Model Intercomparison Project (CMIP5) to observational estimates for the period 1900-2015. We analyse observed and simulated individual contributions to GMSL change (thermal expansion, glacier mass change, ice sheet mass change, landwater storage change) and compare the summed simulated contributions to observed GMSL change over the period 1900-2007 using tide gauge reconstructions, and over the period 1993-2015 using satellite altimetry estimates. The model-simulated contributions allow us to explain 50 ± 30% (uncertainties 1.65σ unless indicated otherwise) of the mean observed change from 1901-1920 to 1988-2007. Based on attributable biases between observations and models, we propose to add a number of corrections, which result in an improved explanation of 75 ± 38% of the observed change. For the satellite era (1993-1997 to 2011-2015) we find an improved budget closure of 102 ± 33% (105 ± 35% when including the proposed bias corrections). Simulated decadal trends over the 20th century increase, both in the thermal expansion and the combined mass contributions (glaciers, ice sheets and landwater storage). The mass components explain the majority of sea-level rise over the 20th century, but the thermal expansion has increasingly contributed to sea-level rise, starting from 1910 onwards and in 2015 accounting for 46% of the total simulated sea-level change. [less ▲]

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See detailShape and spin determination of Barbarian asteroids
Devogele, Maxime ULiege; Tanga, P.; Bendjoya, P. et al

in Astronomy and Astrophysics (2017)

The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such ... [more ▼]

The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such properties were identified. As has been suggested, large scale topographic features could play a role in the polarimetric response, if the shapes of Barbarians are particularly irregular and present a variety of scattering/incidence angles. This idea is supported by the shape of (234) Barbara, that appears to be deeply excavated by wide concave areas revealed by photometry and stellar occultations. Aims. With these motivations, we started an observation campaign to characterise the shape and rotation properties of Small Main- Belt Asteroid Spectroscopic Survey (SMASS) type L and Ld asteroids. As many of them show long rotation periods, we activated a worldwide network of observers to obtain a dense temporal coverage. Methods. We used light-curve inversion technique in order to determine the sidereal rotation periods of 15 asteroids and the con- vergence to a stable shape and pole coordinates for 8 of them. By using available data from occultations, we are able to scale some shapes to an absolute size. We also study the rotation periods of our sample looking for confirmation of the suspected abundance of asteroids with long rotation periods. Results. Our results show that the shape models of our sample do not seem to have peculiar properties with respect to asteroids with similar size, while an excess of slow rotators is most probably confirmed. [less ▲]

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See detailSelf-assembly processes of superparamagnetic colloids in a quasi-two-dimensional system
Rojas, Nicolas; Darras, Alexis ULiege; Lumay, Geoffroy ULiege

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2017), 96(1), 012608

Superparamagnetic colloids gather depending on the magnitude of the magnetic field applied, forming chains and ribbons in a quasi-two-dimensional chamber. The results presented in this work are in good ... [more ▼]

Superparamagnetic colloids gather depending on the magnitude of the magnetic field applied, forming chains and ribbons in a quasi-two-dimensional chamber. The results presented in this work are in good agreement with recent experimental multistable data for the mean length of the aggregates in thermodynamic equilibrium. [less ▲]

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See detailDo Management and Executive Share the same Perception on the critical Issues Facing the Frontline Nursing Staff ?
Nyssen, Anne-Sophie ULiege; GILLET, Aline ULiege; Sougné, Jacques ULiege et al

in International Journal of Healthcare Management (2017)

Changes in managerial practices increasingly distance managers from staff by promoting rotation. It could be thought that this distance changes the perception managers have of work constraints and ... [more ▼]

Changes in managerial practices increasingly distance managers from staff by promoting rotation. It could be thought that this distance changes the perception managers have of work constraints and resources. This study attempts to tackle staff and leadership disparate views on the issues facing front-line nursing staff. We sent an online questionnaire on work constraints and good practices to nursing chiefs from Belgium hospitals and conducted focus groups with their ‘front-line’ nursing staff in order to compare perceptions. 40% of the chief nurses mentioned as a regular problems for their staff: production pressure, working time, doctors–nurses collaboration and managing new staff. Except for the ‘productive pressure’, these issues are rather considered by the staff as occasional problems. Front-line staffs evaluate infrastructure, heat, working positions as more common problems. However, statistical analyses showed one significant difference in perception: management of incidents/accidents. Health care organizations should promote participatory management tools both to diagnose work constraints and to elaborate action priorities in order to guarantee a shared understanding of decisions making between staff and supervisors. [less ▲]

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See detailTypical versus delayed speech onset influences verbal reporting of autistic interests
Chiodo, Liliane ULiege; Majerus, Steve ULiege; Mottron, Laurent

in Molecular Autism (2017)

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is ... [more ▼]

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is associated with clinical, cognitive, and neural differences. It is unknown whether these different speech development pathways and associated cognitive differences are involved in the heterogeneity of the restricted interests that characterize autistic adults. [less ▲]

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See detailAcromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) database.
PETROSSIANS, Patrick ULiege; Daly, Adrian ULiege; Natchev, Emil et al

in Endocrine-Related Cancer (2017)

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly ... [more ▼]

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liege Acromegaly Survey (LAS) database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs. 46.4 years; p<0.001). The median delay from first symptoms to diagnosis was two years longer in females (p=0.015). Ages at diagnosis and first symptoms increased significantly over time (p<0.001). Tumors were larger in males than females (p<0.001); tumor size and invasion were inversely related to patient age (p<0.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (p<0.001). GH was inversely related to age in both sexes (p<0.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in <5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6-4.4% had experienced a fracture. This study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis. [less ▲]

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See detailNatural patches in Posidonia oceanica meadows: the seasonal biogeochemical pore water characteristics of two edge types
Abadie, A; Borges, Alberto ULiege; Champenois, Willy ULiege et al

in Marine Biology (2017), 164:166

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural ... [more ▼]

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural particularity which consist in a duality of their edge types. One edge is eroded by bottom currents, while the adjacent meadow colonizes the bare sediments. This study aims to study the dynamics of these two edges through the investigation of the biogeochemistry (pH, total alkalinity, dissolved inorganic carbon, CO2, CH4, N2O, H2S, dissolved inorganic nitrogen, PO4 3−) within vegetated and unvegetated sediments. These observations are compared with the adjacent meadow to have a better understanding of the colonization processes. Our results reveal that the P. oceanica matrix shows differences from the vegetated edges of sand patches, especially with regard to nutrient availability, which is generally more important at the colonized edge (dissolved inorganic nitrogen up to 65.39 μM in June). A clear disparity also occurs between the eroded and colonized edge with both a seasonal and bathymetrical variation of leaf biomass with higher disparities at 10 m in June (colonized edge 1415 gDW m−2; eroded edge 1133 gDW m−2). Themost important contrasts during this study were assessed in June, suggesting that the warm period of the year is more suitable for sampling to highlight disparate characteristics in temperate seagrass meadows. These findings put into light the potential importance of biogeochemical processes in the dynamics of natural patch edges. We hypothesize that they may influence the structural dynamics of P. oceanica seascapes. [less ▲]

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See detailA palaeoecological model for the late Mesoproterozoic–early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern Africa
Beghin, Jérémie ULiege; Guilbaud, Romain; Poulton, Simon W. et al

in Precambrian Research (2017), 299

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions ... [more ▼]

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions. Here, we combine the geological context and a reconstruction of palaeoenvironmental redox conditions (using iron speciation) with quantitative analysis of microfossil assemblages (eukaryotes andincertae sedis), to provide the first palaeoecological model for the Atar/El Mreïti Group of the Taoudeni Basin. Our model suggests that in the late Mesoproterozoic–early Neoproterozoic, the availability of both molecular oxygen and nutrients controlled eukaryotic diversity, higher in oxic shallow marginal marine environments, while coccoidal colonies and benthic microbial mats dominated respectively in anoxic iron-rich and euxinic waters during marine highstands or away from shore where eukaryotes are lower or absent. [less ▲]

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See detailFardeau des maladies chroniques en Afrique subsaharienne : plaidoyer pour une mise en place des soins palliatifs et d’accompagnement en fin de vie en République démocratique du Congo
Lofandjola Masumbuku, Jacques ULiege

in Ethics, Medicine and Public Health (2017)

Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They ... [more ▼]

Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They require care for more than 6 months (cardiovascular, oncological diseases, chronic respiratory diseases, diabetes and HIV / AIDS), are responsible for 63% death. Relatively little reliable information about these diseases is available. Lists containing the major chronic diseases exist but they are scalable and do not always agree [less ▲]

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See detailNegative velocity fluctuations and non-equilibrium fluctuation relation for a driven high critical current vortex state
Bag, Biplab; Shaw, Gorky ULiege; Banerjee, S. S. et al

in Scientific Reports (2017), 7(1), 5531

Under the influence of a constant drive the moving vortex state in 2H-NbS2 superconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an immobile state. This state ... [more ▼]

Under the influence of a constant drive the moving vortex state in 2H-NbS2 superconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an immobile state. This state possesses a high depinning current threshold ( $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h ) with unconventional depinning characteristics. At currents well above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , the moving vortex state exhibits a multimodal velocity distribution which is characteristic of vortex flow instabilities in the NDR regime. However at lower currents which are just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , the velocity distribution is non-Gaussian with a tail extending to significant negative velocity values. These unusual negative velocity events correspond to vortices drifting opposite to the driving force direction. We show that this distribution obeys the Gallavotti-Cohen Non-Equilibrium Fluctuation Relation (GC-NEFR). Just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , we also find a high vortex density fluctuating driven state not obeying the conventional GC-NEFR. The GC-NEFR analysis provides a measure of an effective energy scale (E eff ) associated with the driven vortex state. The E eff corresponds to the average energy dissipated by the fluctuating vortex state above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h . We propose the high E eff value corresponds to the onset of high energy dynamic instabilities in this driven vortex state just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h . [less ▲]

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See detailGlobal regression model for moisture content determination using near-infrared spectroscopy
Clavaud, Matthieu ULiege; Roggo, Yves; Degardin, Klara et al

in European Journal of Pharmaceutics and Biopharmaceutics (2017), 119

Near-infrared (NIR) global quantitative models were evaluated for the moisture content (MC) determination of three different freeze-dried drug products. The quantitative models were based on 3822 spectra ... [more ▼]

Near-infrared (NIR) global quantitative models were evaluated for the moisture content (MC) determination of three different freeze-dried drug products. The quantitative models were based on 3822 spectra measured on two identical spectrometers to include variability. The MC, measured with the reference Karl Fischer (KF) method, were ranged from 0.05% to 4.96%. Linear and non-linear regression models using Partial Least Square (PLS), Decision Tree (DT), Bayesian Ridge Regression (Bayes-RR), K-Nearest Neighbors (KNN), and Support Vector Regression (SVR) algorithms were created and evaluated. Among them, the SVR model was retained for a global application. The Standard Error of Calibration (SEC) and the Standard Error of Prediction (SEP) were respectively 0.12% and 0.15%. This model was then evaluated in terms of total error and risk-based assessment, linearity, and accuracy. It was observed that MC can be fastly and simultaneously determined in freeze-dried pharmaceutical products thanks to a global NIR model created with different medicines. This innovative approach allows to speed up the validation time and the in-lab release analyses. [less ▲]

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See detailCosmological Time, Entropy and Infinity
Hauret, Clémentine ULiege; Magain, Pierre ULiege; Biernaux, Judith ULiege

in Entropy (2017), 19(7),

Time is a parameter playing a central role in our most fundamental modelling of natural laws. Relativity theory shows that the comparison of times measured by different clocks depends on their relative ... [more ▼]

Time is a parameter playing a central role in our most fundamental modelling of natural laws. Relativity theory shows that the comparison of times measured by different clocks depends on their relative motion and on the strength of the gravitational field in which they are embedded. In standard cosmology, the time parameter is the one measured by fundamental clocks (i.e., clocks at rest with respect to the expanding space). This proper time is assumed to flow at a constant rate throughout the whole history of the universe. We make the alternative hypothesis that the rate at which the cosmological time flows depends on the dynamical state of the universe. In thermodynamics, the arrow of time is strongly related to the second law, which states that the entropy of an isolated system will always increase with time or, at best, stay constant. Hence, we assume that the time measured by fundamental clocks is proportional to the entropy of the region of the universe that is causally connected to them. Under that simple assumption, we find it possible to build toy cosmological models that present an acceleration of their expansion without any need for dark energy while being spatially closed and finite, avoiding the need to deal with infinite values. [less ▲]

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See detailAir-water interfacial properties of enzymatically hydrolyzed wheat gluten in the presence of sucrose
Wouters, Arno G.B.; Fierens, Ellen; Rombouts, Ine et al

in Food Hydrocolloids (2017), (73), 284-294

Enzymatically hydrolyzed wheat gluten proteins may be a valuable alternative to animal proteins as foaming agents in food. Studies of the air-water (A-W) interfacial properties of such hydrolysates in ... [more ▼]

Enzymatically hydrolyzed wheat gluten proteins may be a valuable alternative to animal proteins as foaming agents in food. Studies of the air-water (A-W) interfacial properties of such hydrolysates in aqueous solutions contribute to the understanding of their functionality in food systems. We here studied the A-W interfacial characteristics of wheat gluten hydrolysates (GHs) in the absence and presence of sucrose. Sucrose increased (P < 0.05) the foaming capacity, which is the initial amount of foam formed, of GHs. This is probably related to an increased affinity of GHs for the A-W interface in the presence of sucrose, as could be observed by higher (P < 0.05) rates of diffusion to and adsorption at the A-W interface of the GH constituents in sucrose solution compared to those in water. Furthermore, the surface dilatational moduli of GH protein films at A-Winterfaces were in most cases higher (P < 0.05) in a sucrose solution than in water. The latter could only partly be related to differences in foam stability. Surface hydrophobicity and intrinsic tryptophan fluorescence measurements revealed that protein conformational changes in the presence of sucrose might be at the basis of the observed differences. Another possibility is that the hydrophilic sucrose molecules in the bulk cause the more hydrophobic protein molecules to concentrate at the interface, more so than in water. In conclusion, it is crucial to investigate the foaming of plant protein hydrolysates in media more complex than water, as other nonsurface-active food ingredients alter their interfacial behavior. [less ▲]

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See detailAn active bacterial community linked to high chl-a concentrations in Antarctic winter-pack ice and evidence for the development of an anaerobic sea-ice bacterial community
Eronen-Rasimus, Eeva; Luhtanen, Anne-Mari; Rintala, Janne-Markus et al

in ISME Journal (The) (2017), 1-11

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to ... [more ▼]

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to high (o4 μg l–1) chlorophyll-a (chl-a) concentrations and consequent bacterial production. Typical sea-ice bacterial genera, for example, Octadecabacter, Polaribacter and Glaciecola, often abundant in spring and summer during the sea-ice algal bloom, predominated in the communities. The variability in bacterial community composition in the different ice types was mainly explained by the chl-a concentrations, suggesting that as in spring and summer sea ice, the sea-ice bacteria and algae may also be coupled during the Antarctic winter. Coupling between the bacterial community and sea-ice algae was further supported by significant correlations between bacterial abundance and production with chl-a. In addition, sulphate-reducing bacteria (for example, Desulforhopalus) together with odour of H2S were observed in thick, apparently anoxic ice, suggesting that the development of the anaerobic bacterial community may occur in sea ice under suitable conditions. In all, the results show that bacterial community in Antarctic sea ice can stay active throughout the winter period and thus possible future warming of sea ice and consequent increase in bacterial production may lead to changes in bacteria-mediated processes in the Antarctic sea-ice zone. [less ▲]

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See detailEffects of an experimental resource pulse on the macrofaunal assemblage inhabiting seagrass macrophytodetritus
Remy, François ULiege; Gobert, Sylvie ULiege; Lepoint, Gilles ULiege

in Belgian Journal of Zoology (2017), 147(1), 1-15

Physical disturbances and resource pulses are major structuring drivers of terrestrial and aquatic ecosystems. The accumulations of exported dead leaves from the Neptune grass, Posidonia oceanica (L ... [more ▼]

Physical disturbances and resource pulses are major structuring drivers of terrestrial and aquatic ecosystems. The accumulations of exported dead leaves from the Neptune grass, Posidonia oceanica (L.) Delile are ephemeral and highly dynamic detrital habitats offering food sources and shelter for vagile macrofauna community. These habitats are frequently subject to wind and storms which can add “new” detrital material to previous accumulations; these can be defined as resource pulses and could potentially impact the associated macrofauna. This study assesses the impact of an experimental resource pulse on the macrofauna associated with exported P. oceanica litter accumulations. The experimental design consisted of two pulse treatments (the addition of dead leaves with and without the associated fauna), and two controls (one procedural, and one total control), where the added material was left underwater for 14 days. Invertebrates then present in the sampled detritus were all identified and counted. Our data suggest that the responses of these invertebrates to resource pulses present intermediate characteristics between aquatic and terrestrial ecosystems responses. Inputting a moderate amount of dead P. oceanica leaves into experimental mesocosms had a non-negligible impact and rapidly affected the macrofauna community. Specialist detritivores species were boosted while herbivore/detritivore species dramatically decreased. Predators also showed a modest but significant density increase, demonstrating the fast propagation of the pulse response throughout the entire community and through several trophic levels. Strict hypoxia-tolerant species were also only observed in the treated mesocosms, indicating the strong influence of resource pulses on physico-chemical conditions occurring inside litter accumulations. [less ▲]

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See detailInhibiteurs de la pompe à protons et risque d'insuffisance rénale
PAQUOT, Francois ULiege; Krzesinski, Jean-Marie ULiege

in Revue Médicale Suisse (2017)

Regarded as safe and effective for management of upper peptic ulcer disease due to gastric acid secretion, the proton pump inhibitors are among the most commonly prescribed drugs. Their use, however, is ... [more ▼]

Regarded as safe and effective for management of upper peptic ulcer disease due to gastric acid secretion, the proton pump inhibitors are among the most commonly prescribed drugs. Their use, however, is not without concerns. Acute kidney injury, mainly due to acute interstitial nephritis, could happen 1.5 to 2 times more frequently when using these drugs. Moreover, a risk for chronic kidney disease has also be noted with proton pump inhibitor use (1.15 to 1.8 increased risk), although biases may exist due to confounding factors related to the observational nature of the studies. So, caution is required before available results from good prospective randomized studies are available. Renal function should be checked when using these medications and timely cessation should be advised when there is no more clear indication for use. [less ▲]

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See detailStability of pentaquarks with a two- plus three-body chromoelectric interaction
Stancu, Floarea ULiege

in Physical Review. D : Particles and Fields (2017), 96

We study the stability of pentaquarks within a schematic model based on SU(3) color symmetry, by taking into account algebraic arguments leading to a chromoelectric interaction containing two- and three ... [more ▼]

We study the stability of pentaquarks within a schematic model based on SU(3) color symmetry, by taking into account algebraic arguments leading to a chromoelectric interaction containing two- and three-body parts. It has already been proven that such an interaction can influence the spectrum of ordinary baryons and the stability of tetraquarks and hexaquarks. Here we discuss its role in the stability of pentaquarks against strong decays. [less ▲]

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See detailDoes Belgian Holocene speleothem record solar forcing and cold events?
Allan, Mohammed ULiege; Deliège, Adrien ULiege; Nicolay, Samuel ULiege et al

in Climate of the Past Discussions (2017)

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12 ... [more ▼]

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12.7 ka according to U/Th dating. High spatial resolution measurements of trace elements (Sr, Ba, Mg and Al) were done by Laser-Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Trace elements profiles were interpreted as environmental and climate changes in the Han-sur-Lesse region. Power spectrum estimators and continuous wavelet transform were applied on trace elements time series to detect any statistically significant periodicities in the PN stalagmite. Spectral analyses reveal decadal to millennial periodicities (i.e., 68–75, 133–136, 198–209, 291–358, 404–602, 912–1029 and 2365–2670 yr) in the speleothem record. Results were compared to reconstructed sunspot number data to determine whether solar signal is presents in PN speleothem. The occurrence of significant solar periodicities (i.e., cycles of Gleissberg, de Vries, unnamed 500 years, Eddy and Hallstat) supports for an impact of solar forcing on PN speleothem trace elements contents. Moreover, several intervals of significant rapid climate change were detected during the Holocene at 10.3, 9.3–9.5, around 8.2, 6.4–6.2, 4.7–4.5, and around 2.7 ka BP. Those intervals are similar to the cold events evidenced in different natural paleoclimate archivers, suggesting common climate forcing mechanisms related to changes in solar irradiance. [less ▲]

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See detailMesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1
Rowart, Pascal ULiege; ERPICUM, Pauline ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Stem Cells International (2017)

Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we ... [more ▼]

Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we hypothesized that MSC modulate TJ formation, via the AMP-activated kinase (AMPK) pathway. Liver kinase-β1 (LKB1) and Ca2+-calmodulin-dependent protein kinase kinase (CaMKK) represent the main kinases that activate AMPK. Methods. The in vitro Ca2+ switch from 5 μM to 1.8 mM was performed using epithelial Madin-Darby canine kidney (MDCK) cells cultured alone or cocultured with rat bone marrow-derived MSC or preexposed to MSC-conditioned medium. TJ assembly was measured by assessing ZO-1 relocation to cell-cell contacts. Experiments were conducted using MDCK stably expressing short-hairpin-RNA (shRNA) against LKB1 or luciferase (LUC, as controls). Compound STO-609 (50 μM) was used as CaMKK inhibitor. Results. Following Ca2+ switch, ZO-1 relocation and phosphorylation/activation of AMPK were significantly higher in MDCK/MSC compared to MDCK. No difference in AMPK phosphorylation was observed between LKB1-shRNA and Luc-shRNA MDCK following Ca2+ switch. Conversely, incubation with STO-609 prior to Ca2+ switch prevented AMPK phosphorylation and ZO-1 relocation. MSC-conditioned medium slightly but significantly increased AMPK activation and accelerated TJ-associated distribution of ZO-1 post Ca2+ switch in comparison to regular medium. Conclusions. MSC modulate the assembly of epithelial TJ, via the CaMKK/AMPK pathway independently of LKB1. [less ▲]

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See detailDoes Belgian Holocene speleothem record solar forcing and cold events?
Allan, Mohammed ULiege; Deliège, Adrien ULiege; Nicolay, Samuel ULiege et al

in Climate of the Past Discussions (2017)

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12 ... [more ▼]

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12.7 ka according to U/Th dating. High spatial resolution measurements of trace elements (Sr, Ba, Mg and Al) were done by Laser-Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Trace elements profiles were interpreted as environmental and climate changes in the Han-sur-Lesse region. Power spectrum estimators and continuous wavelet transform were applied on trace elements time series to detect any statistically significant periodicities in the PN stalagmite. Spectral analyses reveal decadal to millennial periodicities (i.e., 68–75, 133–136, 198–209, 291–358, 404–602, 912–1029 and 2365–2670 yr) in the speleothem record. Results were compared to reconstructed sunspot number data to determine whether solar signal is presents in PN speleothem. The occurrence of significant solar periodicities (i.e., cycles of Gleissberg, de Vries, unnamed 500 years, Eddy and Hallstat) supports for an impact of solar forcing on PN speleothem trace elements contents. Moreover, several intervals of significant rapid climate change were detected during the Holocene at 10.3, 9.3–9.5, around 8.2, 6.4–6.2, 4.7–4.5, and around 2.7 ka BP. Those intervals are similar to the cold events evidenced in different natural paleoclimate archivers, suggesting common climate forcing mechanisms related to changes in solar irradiance. [less ▲]

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See detailIn vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (Asteraceae)
Bordignon, Annélise ULiege; Frederich, Michel ULiege; Ledoux, Allison ULiege et al

in Natural Product Research (2017)

According to the World Health Organization (WHO 2016 WHO. 2016. World Malaria report 2016 [Internet]; [cited 2016 Dec 20]. Available from: https://www.who.int/malaria/publications/world-malaria-report ... [more ▼]

According to the World Health Organization (WHO 2016 WHO. 2016. World Malaria report 2016 [Internet]; [cited 2016 Dec 20]. Available from: https://www.who.int/malaria/publications/world-malaria-report-2016/report/en/ [Google Scholar] ), malaria caused at least 429 000 deaths globally in 2015. Among these, 70% were children under the age of five and 99% were due to the parasite species Plasmodium falciparum. The fight against this major public health problem is threatened by the rapid emergence and spread of parasite strains resistant towards available approved treatments. Urgent efforts are therefore needed to identify new antimalarial drugs. As such, our research groups decided to study Reunion Island as a potential source for the discovery of new antiplasmodial metabolites. This natural patrimony has been identified as a biodiversity hotspot due to its numerous endemic species and its preserved ecosystems (Myers et al. 2000 Myers N, Mittermeier RA, Mittermeier CG, DaFonesca GAB, Kent J. 2000. Biodiversity hotspots for conservation priorities. Nature. 403:853–858.10.1038/35002501 [CrossRef], [PubMed], [Web of Science ®], [Google Scholar] ). The National Botanical Conservatory of the Mascarenes indicates that Vernonia fimbrillifera Less. is an endemic species from Reunion Island, locally named ‘bois de source’, which grows in the humid tropical forest (Lavergne and Véra 1989 Lavergne R, Véra R. 1989. Etude ethnobotanique des plantes utilisées dans la pharmacopée traditionnelle à La Réunion [Ethnobotanical study of plants used in the traditional pharmacopoeia of Reunion Island]. Paris: Agence de coopération culturelle et technique. [Google Scholar] ). To the best of our knowledge, neither phytochemical nor pharmacological works have been performed up to now on V. fimbrillifera. This study isolated and determined the structure of three antiplasmodial sesquiterpene lactones. Compounds were additionally tested in vitro for their cytotoxicity and their selectivity indices were established. [less ▲]

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See detailRecurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy
DARCIS, Gilles ULiege; Van der Auwera, Gert; GIOT, Jean-Baptiste ULiege et al

in BMC Infectious Diseases (2017), 17

Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many ... [more ▼]

Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many other infectious or alignant diseases. The disease can present in three ways: cutaneous, mucocutaneous, or visceral leishmaniasis, which rarely occur together or consecutively. Case presentation: The patient was a 52 years old immunosuppressed Belgian woman with a long history of severe rheumatoid arthritis. She underwent bone marrow biopsy to explore thrombocytopenia. Diagnosis of visceral leishmaniasis was made by identification of Leishman Donovan (LD) bodies in macrophages. Treatment with liposomal amphotericin B was successful. She later developed cutaneous leishmaniasis treated with amphotericin B lipid complex. She next presented with relapsing cutaneous lesions followed by rapidly progressing lymphadenopathies. Biopsy confirmed the diagnosis of leishmaniasis. Treatments by miltefosine, amphotericin B, N-methyl-glucamine antimoniate were subsequently initiated. She later presented a recurrent bone marrow involvement treated with intramuscular paromomycin and miltefosine. She died two years later from leukemia. At the time of death, she presented with a mucosal destruction of the nose. A Leishmania-specific PCR (Polymerase Chain Reaction) identified L. infantum as etiological agent. Conclusions: Clinicians should be aware of the potential concomitant or sequential involvement of multiple anatomic localizations of Leishmania in immunosuppressed patients. [less ▲]

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See detailImplicit Belittlements Call for Implicit Measures: Emotional Reactions to Youth Paternalistic Stereotypes
Silvestre, Aude ULiege; Huart, Johanne ULiege; Dardenne, Benoît ULiege

in Psychologica Belgica (2017), 57(2), 133-153

Age discrimination at work can potentially affect every worker. Indeed, like ‘old’ workers, young ones hired in their first job elicit the idea that they have quite interesting social abilities but lack ... [more ▼]

Age discrimination at work can potentially affect every worker. Indeed, like ‘old’ workers, young ones hired in their first job elicit the idea that they have quite interesting social abilities but lack of competence, which constitutes a case of paternalistic stereotypes (Fiske, Cuddy, Glick, & Xu, 2002). Generally, the negative (incompetence) facet of such stereotypes is not blatantly expressed, but is subtly conveyed behind an apparently positive discourse. Consequently, it is considered as being generally under-detected, while harmful. In this paper, we examine whether paternalistic stereotyping’s under-detection is real or if it is due to the use of inadequate measures. Based on a study showing that targets feel that something is wrong (Dardenne, Dumont, & Bollier 2007), we rely on affective measures to investigate whether the detection of the subtly conveyed negative facet of paternalistic stereotypes calls for subtle, implicit measures. In Study 1, explicit self-reports of targets’ affective states after a meeting with a paternalistic boss revealed mainly positive affect. In Study 2, an implicit emotional measure however revealed the presence of a negative affective state. The last Study, using a more ecological affective measure, demonstrates that paternalistic stereotypes trigger an ambivalent affective reaction. Altogether, the three studies suggest that the negative facet of paternalistic stereotypes is not as under-detected as we thought. [less ▲]

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See detailPropagation of material and surface profile uncertainties on MEMS micro-resonators using a stochastic second-order computational multi-scale approach
Lucas, Vincent ULiege; Golinval, Jean-Claude ULiege; Voicu, Rodica et al

in International Journal for Numerical Methods in Engineering (2017), 111(1), 26-68

This paper aims at accounting for the uncertainties due to material structure and surface topology of microbeams in a stochastic multiscale model. For micro-resonators made of anisotropic polycrystalline ... [more ▼]

This paper aims at accounting for the uncertainties due to material structure and surface topology of microbeams in a stochastic multiscale model. For micro-resonators made of anisotropic polycrystalline materials, micro-scale uncertainties are due to the grain size, grain orientation, and to the surface profile. First, microscale realizations of stochastic volume elements (SVEs) are obtained based on experimental measurements. To account for the surface roughness, the SVEs are defined as a volume element having the same thickness as the MEMS, with a view to the use of a plate model at the structural scale. The uncertainties are then propagated up to an intermediate scale, the meso-scale, through a second-order homogenization procedure.From the meso-scale plate resultant material property realizations, a spatially correlated random field of the in plane, out of plane, and cross resultant material tensors can be characterized. Owing to this characterized random field, realizations of MEMS-scale problems can be defined on a plate finite element model. Samples of the macro-scale quantity of interest can then be computed by relying on a Monte-Carlo simulation procedure. As a case study, the resonance frequency of MEMS micro-beams is investigated for different uncertainty cases, such as grain preferred orientations and surface roughness effects. [less ▲]

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See detailConditions for thermally induced all-optical switching in ferrimagnetic alloys: Modeling of TbCo
Moreno, Roberto; Ostler, Thomas ULiege; Chantrell, Roy et al

in Physical Review B (2017), 96

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See detailEffect of Organic Solvents on Microalgae Growth, Metabolism and Industrial Bioproduct Extraction: A Review
Miazek, Krystian ULiege; Kratky, Lukas; Sulc, Radek et al

in International Journal of Molecular Sciences (2017)

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See detailInfluence of environmental factors on food intake among nursing home residents: a survey combined with a video approach
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; Morelle, Alison et al

in Clinical Interventions in Aging (2017), 12

Background: In addition to the well-known physiological factors, dietary behavior that affects health seems to be influenced by a wide variety of environmental factors. The aim of this study was to assess ... [more ▼]

Background: In addition to the well-known physiological factors, dietary behavior that affects health seems to be influenced by a wide variety of environmental factors. The aim of this study was to assess, by means of an original video approach, the influence of the environment on food intake in nursing homes. Methods: The perception of the environment during meals in nursing homes was evaluated by residents and by two groups of volunteers who either work in the field of geriatrics, or who do not work in the field of geriatrics. First, a random sample of residents answered a self-administered questionnaire related to different indicators (ie, noise, space, comfort, light, odors, perceived satisfaction of meals, taste of meals, presentation of meals, service and setting). Second, two separate panels, one including the people who work in the field of geriatrics (ie, experts) and one including the people who have no particular interest in geriatrics (ie, nonexperts), were asked to answer a questionnaire on their perception of the environment after having watched a video of the lunch in each nursing home. Then, the food intake of the residents was measured by a precise food-weighing method. Results: A total of 88 residents from nine different nursing homes, 18 experts and 45 nonexperts answered the questionnaires. This study highlighted that, on the one hand, after adjustment on confounding variables, the perception of the quantity of food served by the residents is the only single factor associated with food consumption (P=0.003). On the other hand, experts and nonexperts did not perceive any environmental factor that seems to be significantly associated with residents’ food intake. Conclusion: Our results highlighted that, in a nursing home setting, environmental factors have limited influence on the food intake of the residents, with the exception of their own perception of the quantity served. The relevance of this factor deserves further investigation. [less ▲]

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See detailProbing the atmosphere of a sub-Jovian planet orbiting a cool dwarf
Sedaghati, Elyar; Boffin, Henri M. J.; Delrez, Laetitia et al

in Monthly Notices of the Royal Astronomical Society (2017), 468

We derive the 0.01 $\mu$m binned transmission spectrum, between 0.74 and 1.0 $\mu$m, of WASP-80b from low resolution spectra obtained with the FORS2 instrument attached to ESO's Very Large Telescope. The ... [more ▼]

We derive the 0.01 $\mu$m binned transmission spectrum, between 0.74 and 1.0 $\mu$m, of WASP-80b from low resolution spectra obtained with the FORS2 instrument attached to ESO's Very Large Telescope. The combination of the fact that WASP-80 is an active star, together with instrumental and telluric factors, introduces correlated noise in the observed transit light curves, which we treat quantitatively using Gaussian Processes. Comparison of our results together with those from previous studies, to theoretically calculated models reveals an equilibrium temperature in agreement with the previously measured value of 825K, and a sub-solar metallicity, as well as an atmosphere depleted of molecular species with absorption bands in the IR ($\gg 5\sigma$). Our transmission spectrum alone shows evidence for additional absorption from the potassium core and wing, whereby its presence is detected from analysis of narrow 0.003 $\mu$m bin light curves ($\gg 5\sigma$). Further observations with visible and near-UV filters will be required to expand this spectrum and provide more in-depth knowledge of the atmosphere. These detections are only made possible through an instrument-dependent baseline model and a careful analysis of systematics in the data. [less ▲]

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See detailGround-based monitoring of comet 67P/Churyumov–Gerasimenko gas activity throughout the Rosetta mission
Opitom, C.; Snodgrass, C.; Fitzsimmons, A. et al

in Monthly Notices of the Royal Astronomical Society (2017), 469

Simultaneously to the ESA Rosetta mission, a world-wide ground-based campaign provided measurements of the large scale activity of comet 67P/Churyumov-Gerasimenko through measurement of optically active ... [more ▼]

Simultaneously to the ESA Rosetta mission, a world-wide ground-based campaign provided measurements of the large scale activity of comet 67P/Churyumov-Gerasimenko through measurement of optically active gas species and imaging of the overall dust coma. We present more than 2 yr of observations performed with the FORS2 low-resolution spectrograph at the VLT, TRAPPIST and ACAM at the WHT. We focus on the evolution of the CN production as a tracer of the comet activity. We find that it is asymmetric with respect to perihelion and different from that of the dust. The CN emission is detected for the first time at 1.34 au pre-perihelion and production rates then increase steeply to peak about 2 weeks after perihelion at (1.00 ± 0.10) × 10[SUP]25[/SUP] molecules s[SUP]-1[/SUP], while the post-perihelion decrease is more shallow. The evolution of the comet activity is strongly influenced by seasonal effects with enhanced CN production when the Southern hemisphere is illuminated. [less ▲]

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See detailChanges in cannabis use in emerging adulthood: The influence of peer network, impulsivity, anxiety and depression
Glowacz, Fabienne ULiege; Schmits, Emilie ULiege

in European Review of Applied Psychology = Revue Européenne de Psychologie Appliquée (2017), 67(4), 171-179

Cannabis is the most commonly used illicit drug with the highest prevalence reported among 15- to 24-year-olds. This specific period of emerging adulthood constitutes a critical age for substance use and ... [more ▼]

Cannabis is the most commonly used illicit drug with the highest prevalence reported among 15- to 24-year-olds. This specific period of emerging adulthood constitutes a critical age for substance use and for future consumption. Cannabis use patterns change during college or university and the post-college transition; users are at greater risk of adverse health outcomes (especially if they start or maintain a pattern of frequent use). Objectives The overall aim of this study was to highlight psychological and relational factors that might be associated with changes (including cessation and fluctuation) in cannabis use during this specific period, separately for males and females. Methods The subjects were 682 first-year college students (69.94% of female), aged between 18 and 25 years (M = 18.59 years, SD = 1.56). Four groups were formed according to cannabis consumption: “non-users” (54.64%), “desisting users” (14.04%), “fluctuating users” (16.23%), and “persistent users” (15.07%). A self-report questionnaire was administered to evaluate prevalence, frequency and trajectory of use, number of peer cannabis users, alcohol use, impulsivity, anxiety (trait and social) and depression. Results Females appear more sensitive to the romantic partner's consumption than males. For both sexes, having more friends who use cannabis appears to be a determinant. Depression and anxiety were not related to changes in cannabis use. Impulsivity is a significant factor for the maintenance of cannabis use in emerging adulthood, with higher lack of premeditation for males and higher sensation seeking for females among fluctuating and persistent users. Conclusions Results are discussed in terms of maintenance of use and the spiral of consumption, including clinical implications for prevention and interventions. [less ▲]

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See detailThe role of mucus in cell-based models used to screen mucosal drug delivery
Lechanteur, Anna ULiege; das Neves, José; Sarmento, Bruno

in Advanced Drug Delivery Reviews (2017)

The increasing interest in developing tools to predict drug absorption through mucosal surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro techniques for drug ... [more ▼]

The increasing interest in developing tools to predict drug absorption through mucosal surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro techniques for drug permeability assessment are less laborious, cheaper and address the concerns of using laboratory animals. Simultaneously, in vitro barrier models that thoroughly simulate human epithelia or mucosae may provide useful data to speed up the entrance of new drugs and new drug products into the clinics. Nevertheless, standard cell-based in vitro models that intend to reproduce epithelial surfaces often discard the role of mucus in influencing drug permeation/absorption. Biomimetic models of mucosae in which mucus production has been considered may not be able to fully reproduce the amount and architecture of mucus, resulting in biased characterization of permeability/absorption. In these cases, artificial mucus may be used to supplement cell-based models but still proper identification and quantification are required. In this review, considerations regarding the relevance of mucus in the development of cell-based epithelial and mucosal models mimicking the gastro-intestinal tract, the cervico-vaginal tract and the respiratory tract, and the impact of mucus on the permeability mechanisms are addressed. From simple epithelial monolayers to more complexes 3D structures, the impact of the presence of mucus for the extrapolation to the in vivo scenario is critically analyzed. Finally, an overview is provided on several techniques and methods to characterize the mucus layer over cell-based barriers, in order to intimately reproduce human mucosal layer and thereby, improve in vitro/in vivo correlation. [less ▲]

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See detailModeling dermatophytosis in reconstructed human epidermis: A new tool to study infection mechanisms and to test antifungal agents
Faway, Emilie; Cambier, Ludivine; Mignon, Bernard ULiege et al

in Medical Mycology (2017), 55(5), 485-494

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See detailH0LiCOW - I. H0 Lenses in COSMOGRAIL's Wellspring: program overview
Suyu, S. H.; Bonvin, V.; Courbin, F. et al

in Monthly Notices of the Royal Astronomical Society (2017), 468

Strong gravitational lens systems with time delays between the multiple images allow measurements of time-delay distances, which are primarily sensitive to the Hubble constant that is key to probing dark ... [more ▼]

Strong gravitational lens systems with time delays between the multiple images allow measurements of time-delay distances, which are primarily sensitive to the Hubble constant that is key to probing dark energy, neutrino physics and the spatial curvature of the Universe, as well as discovering new physics. We present H0LiCOW (H[SUB]0[/SUB] Lenses in COSMOGRAIL's Wellspring), a program that aims to measure H[SUB]0[/SUB] with <3.5 per cent uncertainty from five lens systems (B1608+656, RXJ1131-1231, HE 0435-1223, WFI2033-4723 and HE 1104-1805). We have been acquiring (1) time delays through COSMOGRAIL and Very Large Array monitoring, (2) high-resolution Hubble Space Telescope imaging for the lens mass modelling, (3) wide-field imaging and spectroscopy to characterize the lens environment and (4) moderate-resolution spectroscopy to obtain the stellar velocity dispersion of the lenses for mass modelling. In cosmological models with one-parameter extension to flat Λ cold dark matter, we expect to measure H[SUB]0[/SUB] to <3.5 per cent in most models, spatial curvature Ω[SUB]k[/SUB] to 0.004, w to 0.14 and the effective number of neutrino species to 0.2 (1σ uncertainties) when combined with current cosmic microwave background (CMB) experiments. These are, respectively, a factor of ˜15, ˜2 and ˜1.5 tighter than CMB alone. Our data set will further enable us to study the stellar initial mass function of the lens galaxies, and the co-evolution of supermassive black holes and their host galaxies. This program will provide a foundation for extracting cosmological distances from the hundreds of time-delay lenses that are expected to be discovered in current and future surveys. [less ▲]

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See detailPolarization of the changing-look quasar J1011+5442
Hutsemekers, Damien ULiege; Agis-Gonzalez, Beatriz ULiege; Sluse, Dominique ULiege et al

in Astronomy and Astrophysics (2017), 604

If the disappearance of the broad emission lines observed in changing-look quasars were caused by the obscuration of the quasar core through moving dust clouds in the torus, high linear polarization ... [more ▼]

If the disappearance of the broad emission lines observed in changing-look quasars were caused by the obscuration of the quasar core through moving dust clouds in the torus, high linear polarization typical of type 2 quasars would be expected. We measured the polarization of the changing-look quasar J1011+5442 in which the broad emission lines have disappeared between 2003 and 2015. We found a polarization degree compatible with null polarization. This measurement suggests that the observed change of look is not due to a change of obscuration hiding the continuum source and the broad line region, and that the quasar is seen close to the system axis. Our results thus support the idea that the vanishing of the broad emission lines in J1011+5442 is due to an intrinsic dimming of the ionizing continuum source that is most likely caused by a rapid decrease in the rate of accretion onto the supermassive black hole. Based on observations made with the William Herschel telescope operated on the island of La Palma by the Isaac Newton Group of Telescopes in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. [less ▲]

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See detailM Dwarf Exoplanet Surface Density Distribution: A Log-Normal Fit from 0.07-400 AU
Meyer, Michael R.; Amara, Adam; Reggiani, Maddalena ULiege et al

in Astronomy and Astrophysics Letters (2017), 1707

We fit a log-normal function to the M dwarf orbital surface density distribution of gas giant planets, over the mass range 1-10 times that of Jupiter, from 0.07-400 AU. We use a Markov Chain Monte Carlo ... [more ▼]

We fit a log-normal function to the M dwarf orbital surface density distribution of gas giant planets, over the mass range 1-10 times that of Jupiter, from 0.07-400 AU. We use a Markov Chain Monte Carlo approach to explore the likelihoods of various parameter values consistent with point estimates of the data given our assumed functional form. This fit is consistent with radial velocity, microlensing, and direct imaging observations, is well-motivated from theoretical and phenomenological viewpoints, and makes predictions of future surveys. We present probability distributions for each parameter as well as a Maximum Likelihood Estimate solution. We suggest this function makes more physical sense than other widely used functions, and explore the implications of our results on the design of future exoplanet surveys. [less ▲]

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See detailBaudelaire: traductor auctoritas
Mogollon Zapata, Juan Manuel ULiege

in Literatura: Historia, Teoría, Crítica (2017), 19(2), 19-51

In order to achieve visibility in the media and a position recognized by both the public and their peers, translators are compelled to take advantage of spaces of enunciation such as those provided by ... [more ▼]

In order to achieve visibility in the media and a position recognized by both the public and their peers, translators are compelled to take advantage of spaces of enunciation such as those provided by prefaces, criticism, or biographical notes. Thanks to these spaces, in which translators deploy discursive and institutional strategies that allow them to position themselves and their translation project, translators acquire the status of translator-auctoritas, that is, a level of symbolic authority capable of endowing them with a public image. Through the detailed analysis of the editorial strategies and institutional calculations implemented by Baudelaire in order to position his project of translating Edgar Allan Poe, we show how the poet achieves the status of translator-autoritas and the role the latter played in the construction of his own literary identity [less ▲]

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See detailMUSE-inspired view of the quasar Q2059-360, its Lyman α blob, and its neighborhood
North, P. L.; Marino, R. A.; Gorgoni, C. et al

in Astronomy and Astrophysics (2017), 604

The radio-quiet quasar Q2059-360 at redshift z = 3.08 is known to be close to a small Lyman α blob (LAB) and to be absorbed by a proximate damped Lyα (PDLA) system. Here, we present the Multi Unit ... [more ▼]

The radio-quiet quasar Q2059-360 at redshift z = 3.08 is known to be close to a small Lyman α blob (LAB) and to be absorbed by a proximate damped Lyα (PDLA) system. Here, we present the Multi Unit Spectroscopic Explorer (MUSE) integral field spectroscopy follow-up of this quasi-stellar object (QSO). Our primary goal is to characterize this LAB in detail by mapping it both spatially and spectrally using the Lyα line, and by looking for high-ionization lines to constrain the emission mechanism. Combining the high sensitivity of the MUSE integral field spectrograph mounted on the Yepun telescope at ESO-VLT with the natural coronagraph provided by the PDLA, we map the LAB down to the QSO position, after robust subtraction of QSO light in the spectral domain. In addition to confirming earlier results for the small bright component of the LAB, we unveil a faint filamentary emission protruding to the south over about 80 pkpc (physical kpc); this results in a total size of about 120 pkpc. We derive the velocity field of the LAB (assuming no transfer effects) and map the Lyα line width. Upper limits are set to the flux of the N v λ1238 - 1242, C iv λ1548 - 1551, He ii λ1640, and C iii] λ1548 - 1551 lines. We have discovered two probable Lyα emitters at the same redshift as the LAB and at projected distances of 265 kpc and 207 kpc from the QSO; their Lyα luminosities might well be enhanced by the QSO radiation. We also find an emission line galaxy at z = 0.33 near the line of sight to the QSO. This LAB shares the same general characteristics as the 17 others surrounding radio-quiet QSOs presented previously. However, there are indications that it may be centered on the PDLA galaxy rather than on the QSO. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 60.A-9331(A). [less ▲]

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See detailViolences conjugales et justice pénale: un couple à problémes ? Introduction au dossier
Glowacz, Fabienne ULiege; Vanneste, Charlotte ULiege

in Champ Pénal = Penal Field (2017), Vol. XIV | 2017

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See detailThe thermal structure of the Venus atmosphere: Intercomparison of Venus Express and ground based observations of vertical temperature and density profiles✰
Limaye, Sanjay S.; Lebonnois, Sebastien; Mahieux, Arnaud et al

in Icarus (2017), 294

The Venus International Reference Atmosphere (VIRA) model contains tabulated values of temperature and number densities obtained by the experiments on the Venera entry probes, Pioneer Venus Orbiter and ... [more ▼]

The Venus International Reference Atmosphere (VIRA) model contains tabulated values of temperature and number densities obtained by the experiments on the Venera entry probes, Pioneer Venus Orbiter and multi-probe missions in the 1980s. The instruments on the recent Venus Express orbiter mission generated a significant amount of new observational data on the vertical and horizontal structure of the Venus atmosphere from 40 km to about 180 km altitude from April 2006 to November 2014. Many ground based experiments have provided data on the upper atmosphere (90-130 km) temperature structure since the publication of VIRA in 1985. The "Thermal Structure of the Venus Atmosphere" Team was supported by the International Space Studies Institute (ISSI), Bern, Switzerland, from 2013 to 2015 in order to combine and compare the ground-based observations and the VEx observations of the thermal structure as a first step towards generating an updated VIRA model. Results of this comparison are presented in five latitude bins and three local time bins by assuming hemispheric symmetry. The intercomparison of the ground-based and VEx results provides for the first time a consistent picture of the temperature and density structure in the 40 km-180 km altitude range. The Venus Express observations have considerably increased our knowledge of the Venus atmospheric thermal structure above ∼40 km and provided new information above 100 km. There are, however, still observational gaps in latitude and local time above certain regions. Considerable variability in the temperatures and densities is seen above 100 km but certain features appear to be systematically present, such as a succession of warm and cool layers. Preliminary modeling studies support the existence of such layers in agreement with a global scale circulation. The intercomparison focuses on average profiles but some VEx experiments provide sufficient global coverage to identify solar thermal tidal components. The differences between the VEx temperature profiles and the VIRA below 0.1 mbar/95 km are small. There is, however, a clear discrepancy at high latitudes in the 10-30 mbar (70-80 km) range. The VEx observations will also allow the improvement of the empirical models (VTS3 by Hedin et al., 1983 and VIRA by Keating et al., 1985) above 0.03 mbar/100 km, in particular the 100-150 km region where a sufficient observational coverage was previously missing. The next steps in order to define the updated VIRA temperature structure up to 150 km altitude are (1) define the grid on which this database may be provided, (2) fill what is possible with the results of the data intercomparison, and (3) fill the observational gaps. An interpolation between the datasets may be performed by using available General Circulation Models as guidelines. An improved spatial coverage of observations is still necessary at all altitudes, in latitude-longitude and at all local solar times for a complete description of the atmospheric thermal structure, in particular on the dayside above 100 km. New in-situ observations in the atmosphere below 40 km are missing, an altitude region that cannot be accessed by occultation experiments. All these questions need to be addressed by future missions. [less ▲]

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See detailThe Poetics of (In)visibility: A Stylistic Analysis of Caryl Phillips's Foreigners: Three English Lives
Tunca, Daria ULiege

in Ariel : A Review of International English Literature (2017), 48(3-4), 159-186

Caryl Phillips’s multi-voiced texts have often been studied through the lens of Bakhtinian polyphony. In this essay, I focus on the volume of fictionalized biographies Foreigners: Three English Lives ... [more ▼]

Caryl Phillips’s multi-voiced texts have often been studied through the lens of Bakhtinian polyphony. In this essay, I focus on the volume of fictionalized biographies Foreigners: Three English Lives (2007) to demonstrate that the polyphonic nature of Phillips’s work resides not only in the structural confrontation of characters’ and narrators’ voices but also in the inscription of the writer’s own subjectivity within these individual discourses. Borrowing methods from the discipline of stylistics, I first focus on the use of adjectives and modality in the opening section of Foreigners, “Dr. Johnson’s Watch,” to establish how the first-person narrator’s gradual transition from tentativeness to self-confidence constitutes a way for the implied author, on the one hand, to expose the thwarted logic of the colonially-tinted discourse of his eighteenth-century narrator and, on the other, to offer larger reflections on the process of ideological encoding inherent in the writing of historiography. Such an investigation based on modality furthers allow me to challenge the critical consensus according to which the second section of the book, “Made in Wales,” is a straightforward factual account. Indeed, I suggest that the story of the rise and fall of mixed-race boxer Randolph Turpin is in fact a highly polyphonic narrative featuring increasingly marked clashes in modality and point of view. These, I argue, may draw attention precisely to the problematic construction of historiographical discourse deceptively made to appear so commonsense by the narrator of “Dr. Johnson’s Watch.” [less ▲]

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See detailBack to America: tracking the origin of European introduced populations of Quercus rubra L.
Merceron, Nastasia; Leroy, Thibault; Chancerel, Emilie et al

in Genome = Génome (2017), 60

Abstract: Quercus rubra has been introduced in Europe since the end of the 17th century. It is widely distributed today across this continent and considered invasive in some countries. Here, we ... [more ▼]

Abstract: Quercus rubra has been introduced in Europe since the end of the 17th century. It is widely distributed today across this continent and considered invasive in some countries. Here, we investigated the distribution of genetic diversity of both native and introduced populations with the aim of tracing the origin of introduced populations. A large sampling of 883 individuals from 73 native and 38 European locations were genotyped at 69 SNPs. In the natural range, we found a continuous geographic gradient of variation with a predominant latitudinal component. We explored the existence of ancestral populations by performing Bayesian clustering analysis and found support for two or three ancestral genetic clusters. Approximate Bayesian Computations analyses based on these two or three clusters support recent extensive secondary contacts between them, suggesting that present-day continuous genetic variation resulted from recent admixture. In the introduced range, one main genetic cluster was not recovered in Europe, suggesting that source populations were preferentially located in the northern part of the natural distribution. However, our results cannot refute the introduction of populations from the southern states that did not survive in Europe. [less ▲]

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See detailImaging of super-fast dynamics and flow instabilities of superconducting vortices
Embon, L.; Anahory, Y.; Jelic, Zeljko ULiege et al

in Nature Communications (2017), 8

Quantized magnetic vortices driven by electric current determine key electromagnetic properties of superconductors. While the dynamic behavior of slow vortices has been thoroughly investigated, the ... [more ▼]

Quantized magnetic vortices driven by electric current determine key electromagnetic properties of superconductors. While the dynamic behavior of slow vortices has been thoroughly investigated, the physics of ultrafast vortices under strong currents remains largely unexplored. Here, we use a nanoscale scanning superconducting quantum interference device to image vortices penetrating into a superconducting Pb film at rates of tens of GHz and moving with velocities of up to tens of km/s, which are not only much larger than the speed of sound but also exceed the pair-breaking speed limit of superconducting condensate. These experiments reveal formation of mesoscopic vortex channels which undergo cascades of bifurcations as the current and magnetic field increase. Our numerical simulations predict metamorphosis of fast Abrikosov vortices into mixed Abrikosov-Josephson vortices at even higher velocities. This work offers an insight into the fundamental physics of dynamic vortex states of superconductors at high current densities, crucial for many applications. [less ▲]

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See detailAverage first-passage time of a quasi-Hamiltonian Mathieu oscillator with parametric and forcing excitations
Vanvinckenroye, Hélène ULiege; Denoël, Vincent ULiege

in Journal of Sound and Vibration (2017)

A linear oscillator simultaneously subjected to stochastic forcing and parametric excitation is considered. The time required for this system to evolve from a low initial energy level until a higher ... [more ▼]

A linear oscillator simultaneously subjected to stochastic forcing and parametric excitation is considered. The time required for this system to evolve from a low initial energy level until a higher energy state for the first time is a random variable. Its expectation satisfies the Pontryagin equation of the problem, which is solved with the asymptotic expansion method developed by Khasminskii. This allowed deriving closed-form expressions for the expected first passage time. A comprehensive parameter analysis of these solutions is performed. Beside identifying the important dimensionless groups governing the problem, it also highlights three important regimes which are called incubation, multiplicative and additive because of their specific features. Those three regimes are discussed with the parameters of the problem. [less ▲]

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See detailCognitive brain responses during circadian wake-promotion: evidence for sleep- pressure-dependent hypothalamic activations
Reichert, Carolin Franziska; Maire, Micheline; Gabel, Virginie et al

in Scientific Reports (2017), 7(1),

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See detailRéalisation du attelle de Thomas modifiée pour un membre antérieur
Maquet, Celine ULiege; Casalta, Hélène ULiege; Touati, Kamal ULiege et al

in Point Vétérinaire (2017), 377

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See detailStructural Basis for Plant Plasma Membrane Protein Dynamics and Organization into Functional Nanodomains
Gronnier, Julien; Crowet, Jean-Marc ULiege; Habenstein, Birgit et al

in eLife (2017), 6

Plasma Membrane is the primary structure for adjusting to ever changing conditions. PM sub-compartmentalization in domains is thought to orchestrate signalling cascades. Yet, mechanisms governing membrane ... [more ▼]

Plasma Membrane is the primary structure for adjusting to ever changing conditions. PM sub-compartmentalization in domains is thought to orchestrate signalling cascades. Yet, mechanisms governing membrane organization are mostly uncharacterized. The plant-specific proteins REMORINs are factors regulating hormonal crosstalk and host invasion. REMs are the best-characterized PM nanodomain markers targeted to the PM via an uncharacterized moiety called REMORIN C-terminal Anchor. By coupling biophysical methods, super-resolution microscopy and physiology, we decipher an original mechanism regulating the dynamic and organization of nanodomains. We showed that PM targeting is independent of the COP II-dependent secretory pathway and mediated by PI4P and sterol. REM-CA is an unconventional lipid-binding motif that confers nanodomain organization. Analyses of REM-CA mutants by single particle tracking demonstrate that mobility and supramolecular organization are critical for immunity. This study provides a unique mechanistic insight into how the tight control of spatial segregation is critical in the definition of PM domain necessary to support biological function. [less ▲]

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See detailConsistency of spatiotemporal sound features supports the use of passive acoustics for long-term monitoring
Parmentier, Eric ULiege; Di Iorio, Lucia; Picciulin, Marta et al

in Animal Conservation (2017)

Many studies stress the usefulness of fish calls as effective indicators of distinct species occurrence. However, most of these studies have been undertaken in a given area and during restricted periods ... [more ▼]

Many studies stress the usefulness of fish calls as effective indicators of distinct species occurrence. However, most of these studies have been undertaken in a given area and during restricted periods of time. There is a need to show passive acoustic monitoring is a reliable method to study vocal species over space and time. This study aims to use passive acoustic methods to follow the brown meagre Sciaena umbra at relevant temporal and spatial scales. Specimens of S. umbra were recorded in both aquarium and in the field. In situ recordings were made at two regions (Corsica and Sardinia) during four summers (2008–2012–2013–2015). Temporal and frequency parameters of the fish calls were collected by different teams and compared to test the ability to unequivocally identify the fish sound. The comparison between our data and the bibliography highlights the capability to identify S. umbra during a period of 17 years in different Mediterranean regions, clearly supporting the usefulness of acoustic monitoring to discover and protect aggregation sites of this endangered species. The sound producing mechanism in S. umbra consists of high-speed sonic muscles surrounding dorsally the posterior end of the swim bladder, which can explain the low acoustic variability that helps in the species identification. Similar mechanisms are found in other Sciaenidae, suggesting that a similar conclusion can be drawn for many other adult sciaenids that could be used as sentinel species. This study should be of high interest to policymakers and scientists because it shows passive acoustic can be confidently used in resource management. [less ▲]

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See detailInfusion of mesenchymal stromal cells after deceased liver transplantation: A phase I-II, open-label, clinical study.
DETRY, Olivier ULiege; VANDERMEULEN, Morgan ULiege; DELBOUILLE, Marie-Hélène ULiege et al

in Journal of Hepatology (2017), 67(1), 47-55

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the ... [more ▼]

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the feasibility, safety and tolerability of a single infusion of MSCs in liver transplant recipients. METHODS: Ten liver transplant recipients under standard immunosuppression received 1.5-3x106/kg third-party unrelated MSCs on post-operative day 3+/-2, and were prospectively compared to a control group of 10 liver transplant recipients. As primary end-points, MSC infusional toxicity was evaluated, and infectious and cancerous complications were prospectively recorded until month 12 in both groups. As secondary end-points, rejection rate, month-6 graft biopsies, and peripheral blood lymphocyte phenotyping were compared. Progressive immunosuppression weaning was attempted from month 6 to 12 in MSC recipients. RESULTS: No variation in vital parameters or cytokine release syndrome could be detected during and after MSC infusion. No patient developed impairment of organ functions (including liver graft function) following MSC infusion. No increased rate of opportunistic infection or de novo cancer was detected. As secondary end-points, there was no difference in overall rates of rejection or graft survival. Month-6 biopsies did not demonstrate a difference between groups in the evaluation of rejection according to the Banff criteria, in the fibrosis score or in immunohistochemistry (including Tregs). No difference in peripheral blood lymphocyte typing could be detected. The immunosuppression weaning in MSC recipients was not successful. CONCLUSIONS: No side effect of MSC infusion at day 3 after liver transplant could be detected, but this infusion did not promote tolerance. This study opens the way for further MSC or Treg-based trials in liver transplant recipients. LAY SUMMARY: Therapy with mesenchymal stromal cells (MSCs) has been proposed as a mean to improve results of solid organ transplantation. One of the potential MSC role could be to induce tolerance after liver transplantation, i.e. allowing the cessation of several medications with severe side effects. This study is the first-in-man use of MSC therapy in 10 liver transplant recipients. This study did not show toxicity after a single MSC infusion but it was not sufficient to allow withdrawal of immunosuppression. [less ▲]

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See detailMIP-based constructive heuristics for the three-dimensional Bin Packing Problem with transportation constraints
Paquay, Célia ULiege; Limbourg, Sabine ULiege; Schyns, Michael ULiege et al

in International Journal of Production Research (2017)

This article is about seeking a good feasible solution in a reasonable amount of computation time to the three-dimensional Multiple Bin Size Bin Packing Problem (MBSBPP). The MBSBPP studied considers ... [more ▼]

This article is about seeking a good feasible solution in a reasonable amount of computation time to the three-dimensional Multiple Bin Size Bin Packing Problem (MBSBPP). The MBSBPP studied considers additional constraints encountered in real world air transportation situations, such as cargo stability and the particular shape of containers. This MBSBPP has already been formulated as a Mixed Integer linear Programming problem, but as yet only poor results have been achieved for even fairly small problem sizes. The goal of the work this paper describes is to develop heuristics that are able to quickly provide good initial feasible solutions for the MBSBPP. Three methodologies are considered, which are based on the decomposition of the original problem into easier subproblems: the matheuristics Relax-and-Fix, Insert-and-Fix and Fractional Relax-and-Fix. They have been parametrised on real data sets and then compared to each other. In particular, two of these techniques show promising results in reasonable computational times. [less ▲]

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See detailMapping degenerate vortex states in a kagomé lattice of elongated antidots via scanning Hall probe microscopy
Xue, Cun; Ge, Jun-Yi; He, An et al

in Physical Review. B : Condensed Matter (2017), 96

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe ... [more ▼]

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe microscopy (SHPM). The observed vortex patterns, at specifi c applied magnetic fi elds, are in good agreement with the confi gurations obtained using time-dependent Ginzburg-Landau (TDGL) simulation. Both results indicate that the long range interaction in this nano-structured superconductor is unable to lift degeneracy between different vortex states and the pattern formation is mainly ruled by the nearest neighbour interaction. This simpli cation allows the identi cation of a set of simple rules characterizing the vortex con gurations. We demonstrated that these rules can explain both the observed vortex distributions and the magnetic fi eld dependent degree of degeneracy. [less ▲]

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See detailOptimisation of Ship and Offshore Structures and Effective Waterway Infrastructures to Support the Global Economic Growth of a Country/Region
Rigo, Philippe ULiege; Bayatfar, Abbas ULiege; Buldgen, Loïc ULiege et al

in Ship Science & Technology (2017), 11

This paper is the written support of Prof. Ph. Rigo for his keynote lecture at the 5th International Congress for Ship Design and Naval Engineering (March 2017, Columbia). After presenting of the main ... [more ▼]

This paper is the written support of Prof. Ph. Rigo for his keynote lecture at the 5th International Congress for Ship Design and Naval Engineering (March 2017, Columbia). After presenting of the main research activities at ANAST, ULG, he discussed the way to improve the effectiveness of waterway infrastructures to support the global economic growth of a country/region. This paper includes the following parts:  Ship Structure Optimization: methodology to perform ship scantling optimization, decreasing steel weight and keeping the production cost at an acceptable level. We first review the links between “Design” and “Optimization” and secondly define the place of “Ship Structure Optimization” within the general framework of a “Ship Optimization”.  Ship impacts (Collision), with applications to navigation lock and dry dock gates: these gates have to be designed taking into account accidental loads, such as ship collisions. A new simplified analytical method is proposed, based on the so-called super-element method. This method was developed to rapidly assess the crashworthiness of the collided structure and avoid high computational effort of numerical simulations.  Inland waterway Navigation and the development in South America of Inland Waterway Classifications.  EMSHIP, European ERASMUS MUNDUS education program (www.emship.eu): the unique master in Ship & Offshore Structures awarded by the prestigious European Erasmus Mundus Program. Indeed, EMSHIP shares the outstanding experiences of educators, trainers, industrial partners and students in the rapidly developing areas of marine and offshore engineering industry. [less ▲]

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See detailÉtude de la disponibilité des cavités pour les oiseaux cavernicoles dans la Région de Bruxelles-Capitale
Debois, Caroline; Claessens, Hugues ULiege; Paquet, Jean-Yves et al

in FORÊT.NATURE (2017), (144), 11-20

Selon une étude effectuée en 2002, le nord-ouest de Bruxelles possède une grande disponibilité en cavités pour les oiseaux cavernicoles malgré le fort développement depuis plusieurs décennies de deux ... [more ▼]

Selon une étude effectuée en 2002, le nord-ouest de Bruxelles possède une grande disponibilité en cavités pour les oiseaux cavernicoles malgré le fort développement depuis plusieurs décennies de deux perruches exotiques : la perruche à collier et la perruche alexandre. Suite à l’augmentation des effectifs des deux populations de perruches et suite au renouvellement des vieux peuplements forestiers bruxellois, une limitation du nombre de cavités disponibles pour la nidification des oiseaux cavernicoles est désormais possible. Une nouvelle étude a dès lors été réalisée sur l’ensemble des zones boisées de la Région de Bruxelles-Capitale à l’aide d’un réseau de placettes circulaires disposé aléatoirement dans trois zones distinctes. Dans ces placettes, un inventaire des arbres et des cavités a été effectué avant la période de feuillaison. Par la suite, l’occupation des cavités par les oiseaux cavernicoles a été déterminée. D’après les résultats, un grand nombre de cavités restent disponibles pour la nidification à Bruxelles comme cela avait été établi précédemment. Cela est confirmé par le peu d’interactions observées entre les espèces et par les tendances des populations de cavernicoles, qui sont stables ou en augmentation à Bruxelles de 1992 à 2015. [less ▲]

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See detailCyanobacterial Contribution to Travertine Deposition in the Hoyoux River System, Belgium
Kleinteich, Julia; Golubic, Stjepko; Pessi, Igor S. et al

in Microbial Ecology (2017), 74

Travertine deposition is a landscape-forming process, usually building a series of calcareous barriers differentiating the river flow into a series of cascades and ponds. The process of carbonate ... [more ▼]

Travertine deposition is a landscape-forming process, usually building a series of calcareous barriers differentiating the river flow into a series of cascades and ponds. The process of carbonate precipitation is a complex relationship between biogenic and abiotic causative agents, involving adapted microbial assemblages but also requiring high levels of carbonate saturation, spontaneous degassing of carbon dioxide and slightly alkaline pH. We have analysed calcareous crusts and water chemistry from four sampling sites along the Hoyoux River and its Triffoy tributary (Belgium) in winter, spring, summer and autumn 2014. Different surface textures of travertine deposits correlated with particular microenvironments and were influenced by the local water flow. In all microenvironments, we have identified the cyanobacterium Phormidium incrustatum (Nägeli) Gomont as the organism primarily responsible for carbonate precipitation and travertine fabric by combining morphological analysis with molecular sequencing (16S rRNA gene and ITS, the Internal Transcribed Spacer fragments), targeting both field populations and cultures to exclude opportunistic microorganisms responding favourably to culture conditions. Several closely related cyanobacterial strains were cultured; however, only one proved identical with the sequences obtained from the field population by direct PCR. This strain was the dominant primary producer in the calcareous deposits under study and in similar streams in Europe. The dominance of one organism that had a demonstrated association with carbonate precipitation presented a valuable opportunity to study its function in construction, preservation and fossilisation potential of ambient temperature travertine deposits. These relationships were examined using scanning electron microscopy and Raman microspectroscopy. [less ▲]

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See detailIdentification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting.
Kanis, J.A.; Cooper, C.; Rizzoli, R. et al

in Osteoporosis International (2017), 28(7), 2023-2034

Summary: Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap ... [more ▼]

Summary: Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap. Identification of patients who are at particularly high risk will help clinicians target appropriate treatment more precisely and cost-effectively, and should be the focus of future research. Introduction: The purpose of the study was to review data on the identification and treatment of patients with osteoporosis at increased risk of fracture. Methods: Aworking group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review current data on the epidemiology and burden of osteoporosis and the patterns of medical management throughout Europe. [less ▲]

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See detailA Theory of Soft Capture
Agrell, Per; Gautier, Axel ULiege

in Scandinavian Journal of Economics (2017), 119(3), 571-596

n this paper, wee propose a model for regulatory capture that is based on information transmission and asymmetric information. In a three-tier model, a regulator is charged by a political principal to ... [more ▼]

n this paper, wee propose a model for regulatory capture that is based on information transmission and asymmetric information. In a three-tier model, a regulator is charged by a political principal to provide a signal for the type of a regulated firm. Only the firm can observe his type and the production of a correlated signal with a given accuracy is costly for the regulator. The firm can costlessly provide an alternative signal of lower accuracy that is presented to the regulator. In a self-enforcing equilibrium, the regulator transmits the firm-produced signal, internalizes its own savings in information cost and the firm enjoys higher information rents. The main feature of soft capture is that it is not based on a reciprocity of favors but on a congruence of interests between the firm and the regulator. [less ▲]

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See detailEnhancing erythritol productivity in Yarrowia lipolytica using metabolic engineering
Carly, Frédéric; Vandermies, Marie ULiege; Telek, Samuel ULiege et al

in Metabolic Engineering (2017), 42

Erythritol (1,2,3,4-butanetetrol) is a four-carbon sugar alcohol with sweetening properties that is used by the agrofood industry as a food additive. In this study, we demonstrated that metabolic ... [more ▼]

Erythritol (1,2,3,4-butanetetrol) is a four-carbon sugar alcohol with sweetening properties that is used by the agrofood industry as a food additive. In this study, we demonstrated that metabolic engineering can be used to improve the production of erythritol from glycerol in the yeast Yarrowia lipolytica. The best results were obtained using a mutant that overexpressed GUT1 and TKL1, which encode a glycerol kinase and a transketolase, respectively, and in which EYK1, which encodes erythrulose kinase, was disrupted; the latter enzyme is involved in an early step of erythritol catabolism. In this strain, erythritol productivity was 75% higher than in the wild type; furthermore, the culturing time needed to achieve maximum concentration was reduced by 40%. An additional advantage is that the strain was unable to consume the erythritol it had created, further increasing the process's efficiency. The erythritol productivity values we obtained here are among the highest reported thus far. [less ▲]

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See detailRéalisation du attelle de Thomas modifiée chez le bovin
Maquet, Celine ULiege; Casalta, Hélène ULiege; Sartelet, Arnaud ULiege et al

in Point Vétérinaire (2017), 377

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See detailRéalisation du attelle de Thomas modifiée pour un membre postérieur
Maquet, Celine ULiege; Casalta, Hélène ULiege; Touati, Kamal ULiege et al

in Point Vétérinaire (2017), 377

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See detailSpecular sets
Berthé, Valérie; De Felice, Clelia; Delecroix, Vincent et al

in Theoretical Computer Science (2017), 684

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See detailMacroevolutionary analysis of the tempo of diversification in snappers and fusiliers (Percomorpha: Lutjanidae)
Frederich, Bruno ULiege; Santini, Francesco

in Belgian Journal of Zoology (2017), 147(1), 17-35

The percomorph fish family Lutjanidae (snappers and fusiliers) includes about 135 reef-dwelling species, mainly confined to tropical and subtropical marine waters. The great majority of snappers are ... [more ▼]

The percomorph fish family Lutjanidae (snappers and fusiliers) includes about 135 reef-dwelling species, mainly confined to tropical and subtropical marine waters. The great majority of snappers are active predators feeding on fishes or crustaceans, even though some species, including the fusiliers (Caesioninae), have evolved zooplanktivory. Lutjanids show a great diversity of habitat preferences, based on depth segregation and distribution across reef and associated habitats (e.g. mangroves, seagrass beds, estuaries). In spite of their great ecological and economic importance little is known about the tempo of evolution in this group. The present study provides the most comprehensive molecular phylogeny to date for lutjanids, including 70% of extant species and 19 of the 21 currently described genera. We time-calibrated our molecular tree using the oldest described lutjanid fossils, and show how this group likely originated during the Late Cretaceous to Early Paleocene. Lutjanids experienced significant radiation during the Late Eocene and Early Oligocene, in contrast to a pattern of Late Oligocene/Miocene radiation observed in many other reef-associated groups. The time-tree allows us to investigate the tempo of diversification, and our results suggest a variation in the rate of speciation during the evolution of the major clade formed by “lutjanins and caesionins”. Variation in diet and life history strategies could explain this clade-specific dynamic, even though future phylogenetic comparative studies combining additional ecological and morphological data are needed to test this hypothesis. [less ▲]

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See detailMultiple uprising invasions of Pelophylax water frogs, potentially inducing a new hybridogenetic complex
Dufresne, Christophe; Denoël, Mathieu ULiege; Di Santo, Lionel et al

in Scientific Reports (2017), 7

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to ... [more ▼]

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to reconstruct the scenario of an uprising invasion of the famous water frogs (Pelophylax) in southern France, through a fine-scale genetic survey. We identified three different taxa over less than 200 km2: the autochthonous P. perezi, along with the alien P. ridibundus and P. kurtmuelleri, which have suddenly become invasive. As a consequence, the latter hybridizes and may now form a novel hybridogenetic complex with P. perezi, which could actively promote its replacement. This exceptional situation makes a textbook application of genetics to early-detect, monitor and understand the onset of biological invasions before they pose a continental-wide threat. It further emphasizes the alarming rate of amphibian translocations, both at global and local scales, as well as the outstanding invasive potential of Pelophylax aliens. [less ▲]

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See detailLa Legal Origins Theory : droit, économie, idéologie
Vandenbulke, Antoine ULiege

in Revue Internationale de Droit Economique (2017), 1

The Legal Origins Theory argues that the legal origins of a state have a significant influence on its economic growth. This theory originated mainly and prospered in the field of company law. A group of ... [more ▼]

The Legal Origins Theory argues that the legal origins of a state have a significant influence on its economic growth. This theory originated mainly and prospered in the field of company law. A group of researchers has enquired about the degree of protection granted to minority shareholders in various states throughout the world. They concluded that states belonging to the legal family of common law granted the best protection, sourcing an efficient market and easing their economic growth. The Legal Origins Theory spread out widely and expanded to several other legal domains, while continuing to emphasize and highlight the efficiency of the common law. It was furthermore at the heart of the “Doing Business” reports of the World Bank. This theory has led to many critiques, which the present paper aims to show. Beyond this analysis and the review of criticisms, our study finally attempts to identify the philosophical assumptions that support the Theory of Legal Origins, through the review of the developments authored by Friedrich von Hayek and Bruno Leoni. [less ▲]

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See detailGenetic evaluation of lactation persistency and total milk yield in dairy goats
Siqueira, O. H. G. B. D.; REIS MOTA, Rodrigo ULiege; Oliveira, H. R. et al

in Livestock Research for Rural Development (2017), 29(7),

Lactation persistency (LP) has been neglected over time in genetic evaluations of dairy goats. The main reason for this is the difficulty to infer about the lactation curve shape. However, some lactations ... [more ▼]

Lactation persistency (LP) has been neglected over time in genetic evaluations of dairy goats. The main reason for this is the difficulty to infer about the lactation curve shape. However, some lactations models such as Wood seem to be appropriate to provide persistency estimates under biological viewpoints. The aim of this study was to fit the Wood lactation model as well as to calculate and evaluate LP as selection criteria in dairy goat breeding programs through genetic parameters estimates. A total of 23,265 first lactation test day milk yield observations from 900 animals were used. The Wood random regression model was primarily fitted to estimate the lactation curve parameters (a, b and c), and then LP and total milk yield (TMY). Posteriorly, a multi-trait animal model was fitted considering simultaneously LP and TMY. The heritability estimates were 0.31 and 0.04 for TMY and LP, respectively. Based on the low LP heritability, selection based only on this trait might be inefficient. In conclusion, the results of this study suggests that selecting for high milk yields might result in high persistency since the genetic correlation between LP and TMY was moderate (0.39). [less ▲]

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See detailViolences au sein des relations amoureuses des adolescents et jeunes adultes : une réalité à ne pas négliger
Glowacz, Fabienne ULiege; Courtain, Audrey ULiege

in Champ Pénal = Penal Field (2017), XIV

Au cours des dernières décennies, la violence conjugale a fait l’objet d’un intérêt majeur par la science et la société, donnant lieu à l’élaboration de textes légaux et à des stratégies judiciaires ... [more ▼]

Au cours des dernières décennies, la violence conjugale a fait l’objet d’un intérêt majeur par la science et la société, donnant lieu à l’élaboration de textes légaux et à des stratégies judiciaires, psycho-sociales et préventives spécifiques. Ces avancées ont été initiées par la mobilisation des mouvements féministes qui ont sensibilisé la société aux violences faites aux femmes, tout particulièrement la violence physique, pour ensuite également considérer différentes formes de violences. Ainsi, les recherches scientifiques et les politiques publiques se sont concentrées principalement sur les violences dans les couples entre partenaires adultes. La violence dans les relations amoureuses des adolescents et des jeunes adultes est peu envisagée à un niveau sociétal, alors que la recherche montre que différentes formes de violences sont présentes au sein de ces relations. Dans le cadre de cette contribution, nous proposons de développer sur base d’une revue de la littérature et de données d’enquêtes menées auprès d’adolescents et de jeunes adultes, les spécificités des violences au sein des relations amoureuses durant cette période de développement, leurs prévalences et les dynamiques en cours, ainsi que les iens entre attitudes et violences agies et subies dans les relations amoureuses. Les questions relatives à la bidirectionnalité et à la symétrie de la violence, débattues pour la violence conjugale, seront également discutées à la lumière des éléments émanant des recherches menées au niveau international et d’une enquête menée en Belgique. [less ▲]

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See detailMigraine triggers and habituation of visual evoked potentials
Lisicki Martinez, Marco ULiege; Ruiz-Romagnoli, Emiliano; Piedrabuena, Raul et al

in Cephalalgia : An International Journal of Headache (2017)

Background: Identifying specific subsets of patients within the clinical spectrum of migraine could help in personalizing migraine treatment. Profiling patients by combining clinical characteristics and ... [more ▼]

Background: Identifying specific subsets of patients within the clinical spectrum of migraine could help in personalizing migraine treatment. Profiling patients by combining clinical characteristics and neurophysiological biomarkers is largely unexplored. We studied the association between migraine attack triggers and habituation of visual evoked potentials. Methods: We personally interviewed 25 patients about their migraine triggers following a structured list, and measured the N1-P1 habituation slope over six blocks of 100 averaged pattern-reversal VEP afterwards. Results: The mean number of triggers per patient was 4.52 1.42. Habituation slopes differed significantly between subjects who reported stress as a migraine trigger (deficient VEP habituation) and subjects who did not (preserved VEP habituation). For the remaining categories, the mean amplitude slope was always positive, indicating deficient habituation, and was not significantly different between subgroups. Conclusions: Migraine patients not reporting perceived stress as a trigger for their attacks might constitute a distinct clinic-physiological subset within the migraine spectrum. [less ▲]

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See detailAnalysis of violent and non violent versatility in self-reported juvenile delinquency
Cuervo, Keren; Villanueva, Lidon; Born, Michel ULiege et al

in psychiatry, psychology and law (2017)

Situational action theory (SAT) has emphasized the interaction between individual and social influences on youth crime involvement. In this study, attitudes towards violence, self-control and perception ... [more ▼]

Situational action theory (SAT) has emphasized the interaction between individual and social influences on youth crime involvement. In this study, attitudes towards violence, self-control and perception of neighbourhood are tested in order to determine to what extent they predict versatility in violent and non-violent offences. In order to attain this goal, 2309 Belgian youths aged from 12 to 18 years were administered the Self-report Delinquency Questionnaire. When the offences are divided into violent and non-violent versatilities, the results show differences in the factors that predict delinquency; whereas attitudes towards violence and self-control predict all type of offences, the perception of neighbourhood is only a predictive factor for non-violent offences. External and internal factors need to be included in order to predict the widest range of criminal versatility, since committing a crime involves making choices that depend on the perceived alternatives. [less ▲]

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See detailBuilding a digital agenda for cultural diversity: UNESCO, new governance norms for culture and power dynamics
Vlassis, Antonios ULiege

in Quaderns del CAC (2017), XX(43), 47-54

The Convention on the Protection and Promotion of the Diversity of Cultural Expressions (CDCE) adopted by UNESCO in 2005 is now a key international instrument in the global governance of culture. In ... [more ▼]

The Convention on the Protection and Promotion of the Diversity of Cultural Expressions (CDCE) adopted by UNESCO in 2005 is now a key international instrument in the global governance of culture. In December 2016, the CDCE’s Committee adopted Operational Guidelines in order to align the CDCE with the development of digital technologies. In this respect, this article deals with the struggles between actors in the process for adopting new governance norms for the diversity of cultural expressions in the digital context and it seeks to understand how the interests and influence of the actors involved intersect in consensual and conflicting ways. [less ▲]

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See detailLe recours à l'arbitrage en matière de succession internationale ou la rencontre entre deux mondes qui s'ignorent
Wautelet, Patrick ULiege

in Revue du Notariat Belge (2017), 143(3119), 378-405

L'arbitrage est-il possible et, si oui, dans quelle mesure, dans le domaine des successions internationales? Pour répondre à cette question, le texte prend appui sur le Règlement 650/2012. L’arbitrage ... [more ▼]

L'arbitrage est-il possible et, si oui, dans quelle mesure, dans le domaine des successions internationales? Pour répondre à cette question, le texte prend appui sur le Règlement 650/2012. L’arbitrage présente des avantages considérables pour régler les différends issus d’une suc- cession présentant une dimension internationale. Des obstacles importants peuvent néanmoins limiter, voire empêcher le recours à l’arbitrage en matière successorale. Sont abordées successivement dans cette contribution, les questions d'accès à l'arbitrage et de déroulement de l'arbitrage, en particulier sous l'angle du droit applicable à l'arbitrage successoral. Deux difficultés majeures seront examinées au titre des questions relatives à l'accès à l'arbitrage : la première tient à la possibilité pour une juridiction arbitrale de se prononcer sur les droits réservataires dont bénéficient certains proches du défunt, la seconde à la fragilité qui pèse sur le choix par un testateur de confier à une juridiction arbitrale la résolution des différends. [less ▲]

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See detailLe système semencier en question
Hecquet, Corentin ULiege; Stassart, Pierre M ULiege

in MILLE LIEUX (2017), 06

Les enjeux de biodiversité, le procès contre l’association Kokopelli, une demande accrue d’une alimentation saine et respectueuse, le désir d’autonomie d’agricul- teurs nourrissent les interrogations ... [more ▼]

Les enjeux de biodiversité, le procès contre l’association Kokopelli, une demande accrue d’une alimentation saine et respectueuse, le désir d’autonomie d’agricul- teurs nourrissent les interrogations par rapport au fonctionnement du système se- mencier. Cet article dépeint le système semencier européen et les critiques dont il fait l’objet. Ne sont pas abordés ici la réglementation phytosanitaire1, la certification de certaines espèces ni les OGM2. La législation européenne concernant la circula- tion des semences est régie par une dizaine de directives. Les droits de propriétés intellectuelles sur les semences sont régis, quant à eux, par les conventions au sein de l’Union internationale pour la Protection des Obtentions Végétales (UPOV) et au niveau européen, l’Office Communautaire des Variétés Végétales (OCVV) soutient les mécanismes de Certification d’Obtentions Végétales (COV). [less ▲]

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See detailChemical abundances of fast-rotating massive stars. I. Description of the methods and individual results
Cazorla, Constantin ULiege; Morel, Thierry ULiege; Nazé, Yaël ULiege et al

in Astronomy and Astrophysics (2017), 603(A56),

Aims: Recent observations have challenged our understanding of rotational mixing in massive stars by revealing a population of fast- rotating objects with apparently normal surface nitrogen abundances ... [more ▼]

Aims: Recent observations have challenged our understanding of rotational mixing in massive stars by revealing a population of fast- rotating objects with apparently normal surface nitrogen abundances. However, several questions have arisen because of a number of issues, which have rendered a reinvestigation necessary; these issues include the presence of numerous upper limits for the nitrogen abundance, unknown multiplicity status, and a mix of stars with different physical properties, such as their mass and evolutionary state, which are known to control the amount of rotational mixing. Methods: We have carefully selected a large sample of bright, fast-rotating early-type stars of our Galaxy (40 objects with spectral types between B0.5 and O4). Their high-quality, high-resolution optical spectra were then analysed with the stellar atmosphere modelling codes DETAIL/SURFACE or CMFGEN, depending on the temperature of the target. Several internal and external checks were performed to validate our methods; notably, we compared our results with literature data for some well-known objects, studied the effect of gravity darkening, or confronted the results provided by the two codes for stars amenable to both analyses. Furthermore, we studied the radial velocities of the stars to assess their binarity. Results: This first part of our study presents our methods and provides the derived stellar parameters, He, CNO abundances, and the multiplicity status of every star of the sample. It is the first time that He and CNO abundances of such a large number of Galactic massive fast rotators are determined in a homogeneous way. [less ▲]

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See detailComparative Phytochemical Composition and Hypoglycemic Activity of Some Plants Used by Traditional Healers to Treat Diabetes in Kisangani
KATEMO MUHOYA, Frédéric; Kadima Ntokamunda, Justin-Léonard; Marini Djang'Eing'A, Roland ULiege

in International Journal of Pharmacy & Pharmaceutical REsearch (2017), Vol. 9(Issue 4), 312-321

Background: Phytochemical and Biological studies are always needed to define chemical composition, bioactivity and toxicity of plants from folk medicines before integrating them into conventional ... [more ▼]

Background: Phytochemical and Biological studies are always needed to define chemical composition, bioactivity and toxicity of plants from folk medicines before integrating them into conventional medicines. Here we compared phytochemical composition and antihyperglycemic activity of some plants used in Kisangani to treat diabetes. Methods: The plants tested are Aloe vera (AV), Bidens pilosa (BP), Cassia alata (CA), Cassia occidentalis (CO), Catharanthus roseus pink flower (CRp), Catharanthus roseus white flower or alba (CRw), Mangifera indica (MI), Morinda lucida (ML), Morinda morindoides (MM), Panda oleosa (PO), Terminalia catappa (TC), and Vernonia amygdalina (VA). Their content in polyphenols, saponins, alkaloids and mineral ash were compared. Hyperglycemia was induced in rabbits by oral glucose tolerance test with glibenclamide 0.2 mg/kg as reference. Blood glucose level was assayed by Folin-Wu photometric method. The mean percentage in glucose level reduction (MPR) was calculated from control untreated animals. The relative potency of each extract (RP) was calculated from glibenclamide MPR taken as 100%. Results: Flavonoids, tannins and saponins, were the main components; alkaloids were found only in CRp, CRw, ML and MM. The water content varied from 67% to 88%; Total ashes content was lower in roots (9%) than other parts (11-16%). Glibenclamide gave MPR=56.8% and RP=100%. MPR and RP for plant extracts were, ML(29.8%; 52.4%), CA(31.9%; 56.2%), MI(46.6%; 81.9%), MM(46.6%; 81.9%), TC(47.2%; 83.1%), VA(49.4%; 86.9%), CO(54.4%; 95.8%), CRw(57.4%; 101.0%), BP(60.8%; 107.0%), CRp(63.2%; 111.1%), AV(64.5%; 113.4%), PO(83.2%;146.3%). Conclusion: All plants but Panda oleosa have been studied by others; the main phytochemical groups reported have been confirmed in the local species. All plants exhibited some antihyperglycemic activity, differing however by their relative potency. [less ▲]

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See detail10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension
Bone, H.G.; Wagman, R.B.; Brandi, M.L. et al

in Lancet Diabetes & Endocrinology (2017), 5

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See detailViolences conjugales : un dilemme pour la justice pénale ? Leçons d’une analyse des enregistrements statistiques effectués dans les parquets belges
Vanneste, Charlotte ULiege

in Champ pénal/Penal field (2017), XIV

Drawing on the analysis of statistics regarding Intimate Partner Violence collected on a large scale at the level of the Belgian prosecutors’ offices, the article reveals a wide gap between the zero ... [more ▼]

Drawing on the analysis of statistics regarding Intimate Partner Violence collected on a large scale at the level of the Belgian prosecutors’ offices, the article reveals a wide gap between the zero tolerance rhetoric conveyed in the normative discourse and actual implementation, which is generally weak and showing divergent judicial practices in the field. Faced with this dilemma, the highly contestable impact of the zero tolerance policy observed in preventing recidivism offers a substantial argument to revisit the role of the criminal justice system in this area. [less ▲]

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See detailThe European Union’s Ambition to Harmonize Rules to Counter the Abuse of Member States’ Disparate Tax Legislations
Docclo, Caroline ULiege

in Bulletin for International fiscal documentation (2017)

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See detailA Receding Horizon Approach to Incorporate Frequency Support into the AC/DC Converters of a Multi-Terminal DC Grid
Papangelis, Lampros ULiege; Panciatici, Patrick; Debry, Marie-Sophie et al

in Electric Power Systems Research (2017)

This paper proposes a novel control scheme for provision of frequency support among asynchronous AC areas through HVDC grids. It is based on local controllers, each acting on a voltage source converter ... [more ▼]

This paper proposes a novel control scheme for provision of frequency support among asynchronous AC areas through HVDC grids. It is based on local controllers, each acting on a voltage source converter, using local measurements only, and supporting frequency of the adjacent AC area after a significant disturbance. The new discrete control is combined with the existing DC voltage droop technique. The formulation, inspired of Receding Horizon Control, enables providing to the AC area the desired frequency support, while at the same time taking into account various constraints, such as maintaining the DC voltage between secure operating limits. Examples obtained from a test system with a five-terminal DC network connecting two asynchronous areas demonstrate the effectiveness and robustness of the proposed control scheme in various scenarios, with emphasis on component failures. [less ▲]

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See detailFaire émerger les problèmes (présentation du dossier)
Gavray, Marc-Antoine ULiege

in Diotime. Revue internationale de didactique de la philosophie (2017), 73

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See detailNatural and induced loss of function mutations in SlMBP21 MADS-box gene led to jointless-2 phenotype in tomato
Gomez Roldan, Maria Victoria; Périlleux, Claire ULiege; Morin, Halima et al

in Scientific Reports (2017), 7

Abscission is the mechanism by which plants disconnect unfertilized flowers, ripe fruits, senescent or diseased organs from the plant. In tomato, pedicel abscission is an important agronomic factor that ... [more ▼]

Abscission is the mechanism by which plants disconnect unfertilized flowers, ripe fruits, senescent or diseased organs from the plant. In tomato, pedicel abscission is an important agronomic factor that controls yield and post-harvest fruit quality. Two non-allelic mutations, jointless (j) and jointless-2 (j-2), controlling pedicel abscission zone formation have been documented but only j-2 has been extensively used in breeding. J was shown to encode a MADS-box protein. Using a combination of physical mapping and gene expression analysis we identified a positional candidate, Solyc12g038510, associated with j-2 phenotype. Targeted knockout of Solyc12g038510, using CRISPR/Cas9 system, validated our hypothesis. Solyc12g038510 encodes the MADS-box protein SlMBP21. Molecular analysis of j-2 natural variation revealed two independent loss-of-function mutants. The first results of an insertion of a Rider retrotransposable element. The second results of a stop codon mutation that leads to a truncated protein form. To bring new insights into the role of J and J-2 in abscission zone formation, we phenotyped the single and the double mutants and the engineered alleles. We showed that J is epistatic to J-2 and that the branched inflorescences and the leafy sepals observed in accessions harboring j-2 alleles are likely the consequences of linkage drags. [less ▲]

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See detailThe influence of health concerns in scientific and policy debates on climate change
Schütte, Stefanie; Depoux, Anneliese; Vigil Diaz Telenti, Sara ULiege et al

in Journal of Epidemiology & Community Health (2017)

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