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See detailCO2-sourced α-alkylidene cyclic carbonates: a Step forward in the quest for functional regioregular poly(urethane)s and poly(carbonate)s
Gennen, Sandro ULiege; Grignard, Bruno ULiege; Tassaing, Thierry et al

in Angewandte Chemie International Edition (2017), 56(35), 1039410398

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene ... [more ▼]

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene carbonates by various nucleophiles. The remarkable reactivity of α-alkylidene carbonates is dictated by the exocyclic olefinic group that selectively orients the cyclic carbonate ring- opening with the formation of an enol species. The polyaddition of CO2 -sourced bis-α-alkylidene carbonates (bis-αCCs) with primary and secondary diamines provides novel regioregular functional poly(urethane)s. The reactivity of bis-αCCs is also exploited for producing new poly(β-oxo-carbonate)s by organocatalyzed polyaddition with a diol. All polyadditions were feasible under ambient conditions. This synthesis platform provides new functional variants of world-class leading polymers families (polyurethanes, polycarbonates) and valorises CO2 as a chemical feedstock. [less ▲]

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See detailEffect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
Tarasco, Erika; Seebeck, Petra; Pfundstein, Svende et al

in Endocrine (2017)

Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as ... [more ▼]

Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies. AP102 is a new somatostatin analogs with high affinity at both SSTR2 and SSTR5. We aimed to characterize the effects of AP102 vs. pasireotide on random and dynamic glucose levels, glucoregulatory hormone concentrations and growth axis measures in healthy Sprague-Dawley rats. [less ▲]

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See detailSupercritical Fluid Chromatography in Traditional Chinese Medicine Analysis
Huang, Yang ULiege; Tang, Guangyun; Zhang, Tingting et al

in Journal of Pharmaceutical and Biomedical Analysis (2017)

Traditional Chinese medicines (TCMs) are gaining increasing popularity throughout the world due to their long historical clinical practices. Highly efficient analytical separation tools are essential for ... [more ▼]

Traditional Chinese medicines (TCMs) are gaining increasing popularity throughout the world due to their long historical clinical practices. Highly efficient analytical separation tools are essential for investigating the mysterious properties of TCMs and their quality control. Supercritical fluid chromatography (SFC) showed a great potential in TCM analysis for both nonpolar and polar components. In this paper, an overview of the experimental conditions (i.e. detection mode, stationary phase, mobile phase composition, pressure and temperature) used in SFC for achiral separations of TCM components is presented and recent applications to the analysis of different classes of compounds extracted from TCMs, such as lipids, terpene and terpenoids, phenolic compounds, flavonoids, alkaloids, saponins and carbohydrates, will be briefly described. [less ▲]

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See detailProtein–polysaccharide complexes for enhanced protein delivery in hyaluronic acid templated calcium carbonate microparticles
Ramalapa, Bathabile ULiege; Crasson, Oscar ULiege; Vandevenne, Marylène ULiege et al

in Journal of Materials Chemistry B (2017), 5

The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated. The success of these carriers is driven by ionic interactions between the encapsulated ... [more ▼]

The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated. The success of these carriers is driven by ionic interactions between the encapsulated proteins and the particles. This poses a great limitation on the successful loading of proteins that have no ionic affinity to CaCO3. In this study, we explored the use of polysaccharide–protein interactions to strongly enhance the encapsulation of proteins in CaCO3 microparticles. Previously, Vandevenne and colleagues inserted a human chitin binding domain (ChBD) that has intrinsic affinity for hyaluronic acid (HA) into a β-lactamase (BlaP). This generated chimeric protein, named BlaPChBD, was shown to be fully bifunctional. In this study we showed that this hybrid protein can associate with HA and be successfully loaded into vaterite CaCO3 microparticles using supercritical CO2 (ScCO2) technology aided by the templating effect of HA on CaCO3. The presence of ChBD inserted into BlaP increased the encapsulation of the protein by 6-fold when complexed with HA. Furthermore, thrombin cleavage sites were engineered on both sides of the inserted ChBD in the chimeric BlaP to achieve release of the protein from the microparticles by protease cleavage. Our results showed that thrombin cleavage increased the release of the protein from the microparticles within 36 hours from <20% to 87%. In conclusion, the presence of ChBD successfully improved the encapsulation yield of the protein while retaining up to 82% of its activity and efficient release of the protein from the microparticles was achieved by protease cleavage. [less ▲]

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See detailComplete mitogenome sequence of Ricasolia amplissima (Lobariaceae) reveals extensive mitochondrial DNA rearrangement within the Peltigerales (lichenized ascomycetes)
Simon, Antoine ULiege; Liu, Yang; Sérusiaux, Emmanuël ULiege et al

in Bryologist (2017), 120(3), 335-339

The structure of mitochondrial genomes varies among non-lichenized fungi in terms of their genic and intronic content and genic order. Whether lichenized fungal mitogenomes are equally labile is unknown ... [more ▼]

The structure of mitochondrial genomes varies among non-lichenized fungi in terms of their genic and intronic content and genic order. Whether lichenized fungal mitogenomes are equally labile is unknown due to the paucity of available mitogenomes. We assembled the mitogenome of Ricasolia amplissima (Peltigerales, Lobariaceae), using massive parallel sequencing, and compared its structure to that of two species of Peltigera (Peltigeraceae). The mitochondrial genome of R. amplissima comprised 82,333 bp, with a 29.8% G+C content, and holds 15 unique protein-coding genes, 29 tRNA genes, two rRNA genes, and one non-coding RNA gene. Although the protein-coding gene content in the mitogenome of Peltigera and Ricasolia was identical, the relative gene order differed substantially, revealing that significant gene rearrangements also characterize the evolution of mitogenomes of lichenized ascomycetes at a relatively shallow phylogenetic depth, such as within the order Peltigerales. [less ▲]

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See detailLe cercle de lecture, un dispositif pour construire ensemble des compétences de lecteurs et d'enseignants
Scheepers, Caroline ULiege; Outers, Pierre ULiege; Werner, Anne-Catherine ULiege et al

in Didactiques en Pratique (2017)

Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé ... [more ▼]

Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé, analysé et discuté un projet collaboratif qui a associé étroitement théorie et pratique, université et école secondaire, expérimentation et transposition d’un dispositif, didactique disciplinaire et didactique générale. Plus concrètement, il s’est agi de faire expérimenter en tant qu’apprenants un cercle de lecture et un atelier d’écriture par les étudiants romanistes qui suivent le cours de première année de master centré sur la didactique du français langue première, avant de les inviter à transposer l’outil ainsi testé dans leur classe de stage. Seront prises en compte différentes traces : nos consignes, les journaux de stage, les portfolios, les consignes des étudiants, les traces recueillies auprès des élèves du secondaire, les rapports des maitres de stage, etc. Nous verrons in fine que le processus mis en place confirme, toutes proportions gardées, la validité et la pertinence du principe d’homologie entre les activités testées par les stagiaires lors de leur formation initiale à l’université et celles que les formateurs leur recommandent de mettre en œuvre dans leurs classes. [less ▲]

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See detail3D thermal finite element analysis of laser cladding processed Ti-6Al-4V part with microstructural correlations
Tran, Hoang Son ULiege; Tchuindjang, Jérôme Tchoufack ULiege; Paydas, Hakan ULiege et al

in Materials & Design (2017), 128

In this study, a 3D thermal model of laser cladding by powder injection applied to Ti-6Al-4V is developed. The manufactured part is made of a Ti-6Al-4V substrate on which successive layers of laser melted ... [more ▼]

In this study, a 3D thermal model of laser cladding by powder injection applied to Ti-6Al-4V is developed. The manufactured part is made of a Ti-6Al-4V substrate on which successive layers of laser melted powder are added, leading to a thick deposit. The computed temperature field and its time evolution are compared to experimental measurements. The temperature distribution in the substrate allows the prediction of the depths of the melt pool and the heat affected zone. Correlations between simulated thermal histories and the final microstructure in the thick deposit are established, leading to the enhancement of a dynamic shift of the critical transformation points due to high thermal rates during laser processing. The nature of the phases present within the deposit is discussed. [less ▲]

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See detailSuperparamagnetic colloids in viscous fluids
Darras, Alexis ULiege; Opsomer, Eric ULiege; Vandewalle, Nicolas ULiege et al

in Scientific Reports (2017), 7

The influence of a magnetic field on the aggregation process of superparamagnetic colloids has been well known on short time for a few decades. However, the influence of important parameters, such as ... [more ▼]

The influence of a magnetic field on the aggregation process of superparamagnetic colloids has been well known on short time for a few decades. However, the influence of important parameters, such as viscosity of the liquid, has received only little attention. Moreover, the equilibrium state reached after a long time is still challenging on some aspects. Indeed, recent experimental measurements show deviations from pure analytical models in extreme conditions. Furthermore, current simulations would require several years of computing time to reach equilibrium state under those conditions. In the present paper, we show how viscosity influences the characteristic time of the aggregation process, with experimental measurements in agreement with previous theories on transient behaviour. Afterwards, we performed numerical simulations on equivalent systems with lower viscosities. Below a critical value of viscosity, a transition to a new aggregation regime is observed and analysed. We noticed this result can be used to reduce the numerical simulation time from several orders of magnitude, without modifying the intrinsic physical behaviour of the particles. However, it also implies that, for high magnetic fields, granular gases could have a very different behaviour from colloidal liquids. [less ▲]

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See detailMathematical modeling of extracorporeal CO2 removal therapy. A validation carried out on ten pigs
Habran, Simon ULiege; Desaive, Thomas ULiege; MORIMONT, Philippe ULiege et al

in Medical & Biological Engineering & Computing (2017)

The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syn- drome (ARDS) or chronic obstructive pulmonary ... [more ▼]

The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syn- drome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO2 removal therapy (ECCO2RT). The sim- ulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO2 during ECCO2RT for different blood flows across the extracorporeal lung support. [less ▲]

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See detailImpact of canopy aerodynamic distance spatial and temporal variability on long term eddy covariance measurements
Hurdebise, Quentin ULiege; Heinesch, Bernard ULiege; De Ligne, Anne ULiege et al

in Agricultural and Forest Meteorology (2017), 247(2017), 131-138

Understanding if and how the spatial and temporal variability of the surrounding environment affects turbulence is essential for long-term eddy covariance measurements. It requires characterizing the ... [more ▼]

Understanding if and how the spatial and temporal variability of the surrounding environment affects turbulence is essential for long-term eddy covariance measurements. It requires characterizing the surrounding environment. One way to achieve this is to analyse the canopy aerodynamic distance (Δ), which is the difference between measurement height (zm) and displacement height (d). In this work, an original method to estimate the canopy aerodynamic distance at a fine spatial (30° sectors) and temporal (one year) resolution was proposed. It was based on sensible heat cospectra analysis, calibrated on a measurement height change and validated using canopy height inventories. This method was applied to 20 years of eddy covariance measurements from the Vielsalm Terrestrial Observatory (VTO), a site located in a mixed temperate forest. The method allowed Δ spatio-temporal variability due to changes in canopy or measurement height to be detected. Relationships between Δ and turbulence statistics were then analysed: the momentum correlation coefficient (ruw) was found to be dependent on Δ, confirming that the measurements were made in the roughness sublayer of the atmospheric surface layer. In contrast, no such relationship was found sensible heat, CO2 or water vapour correlation coefficients, suggesting that the Δ variability did not affect significantly these fluxes. There were significant differences, however, between azimuthal directions, suggesting that these scalars were affected by forest heterogeneity in a different way. Various hypotheses were put forward to explain the differences and their relevance was evaluated. This study highlighted the need to consider the spatial and temporal variability of the surrounding environment in order to verify the consistency of long-term eddy covariance datasets. [less ▲]

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See detailMild synthesis of poly(HEMA)-networks as well-defined nanoparticles in supercritical carbon dioxide
Parilti, Rahmet ULiege; Alaimo, David; Grignard, Bruno ULiege et al

in Journal of Materials Chemistry B (2017), 5(29), 5806-5815

Free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate was carried out in supercritical carbon dioxide (scCO2) in the presence of stabilisers based on polyethylene oxide (PEO) and poly ... [more ▼]

Free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate was carried out in supercritical carbon dioxide (scCO2) in the presence of stabilisers based on polyethylene oxide (PEO) and poly(heptadecafluorodecyl acrylate) (PFDA). Different architectures of copolymers (random, palm-tree and diblock) were tested for their surface tension, cloud point and as a stabilising agent. The diblock architecture was found to be the best candidate resulting in poly(HEMA) spherical particles with a size of 316 nm. Furthermore, the effect of the CO2-phobic block (PEO) in the diblock architecture was investigated by using three different chain lengths (1000, 2000, 5000 g mol−1). By optimizing the stabiliser composition and structure, mild reaction conditions have been identified allowing us to obtain well-defined spherical cross-linked poly(HEMA) particles with a mean diameter of unprecedented low size (216 nm) at a temperature as low as 35 °C. [less ▲]

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See detailOviposition deterrent activity of basil plants and their essentials oils against Tuta absoluta (Lepidoptera: Gelechiidae)
Yarou, Boni Barthélémy ULiege; Bawin, Thomas; Boullis, Antoine ULiege et al

in Environmental Science and Pollution Research (2017)

The leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most important pests of tomato, reducing crop yields by up to 100% in greenhouses and fields, in several countries globally ... [more ▼]

The leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most important pests of tomato, reducing crop yields by up to 100% in greenhouses and fields, in several countries globally. Because synthetic insecticides lead to resistance and have adverse effects on natural enemies and the health of producers, alternative control methods are needed. In this study, we assessed the oviposition-deterring effect of basil plants, Ocimum gratissimum L. and O. basilicum L. (Lamiaceae), using dual-choice behavioural assays performed in flight tunnels. We found that both plants significantly reduced T. absoluta oviposition behaviour on a tomato plant located nearby. To evaluate the potential effect of basil volatile organic compounds, we formulated essential oils of both plant species in paraffin oil, and observed a similar oviposition-deterring effect. Gas chromatography analyses detected 18 constituents in these essential oils which the major constituents included thymol (33.3%), p-cymene (20.4%), γ-terpinene (16.9%), myrcene (3.9%) in O. gratissimum and estragol (73.8%), linalool (8.6%), β-elemene (2.9%) and E-β-ocimene (2.6%) in O. basilicum. Twenty and 33 compounds were identified of the volatiles collected on O. gratissimum and O. basilicum plants, respectively. The main components include the following: p-cymene (33.5%), γ-terpinene (23.6%), α-terpinene (7.2%), α-thujene (6.7%) and E-α-bergamotene (38.9%) in O. gratissimum, and methyl eugenol (26.1%), E-β-ocimene (17.7%), and linalool (9.4%) in O. basilicum. Four compounds (α-pinene, β-pinene, Myrcene, Limonene) were common in essential oils and plants. Our results suggest the valuable potential of basil and associated essential oils as a component of integrated management strategies against the tomato leafminer. [less ▲]

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See detailOne-Tooth One-Time (1T1T): a straightforward approach to replace missing teeth in the posterior region
Lambert, France ULiege; Mainjot, Amélie ULiege

in Journal of Oral Implantology (The) (2017)

Advances in Computer-Aided Design and Manufacturing (CAD-CAM) composite materials and chair-side CAD-CAM systems offer a new landscape for the implant dentistry. Digital workflows are increasingly used ... [more ▼]

Advances in Computer-Aided Design and Manufacturing (CAD-CAM) composite materials and chair-side CAD-CAM systems offer a new landscape for the implant dentistry. Digital workflows are increasingly used, especially for single-unit restorations, and they allow straightforward and cost-effective protocols that improve patient satisfaction. The efficacy of immediate loading on single implants has been demonstrated (1, 2). Currently, to 12 promote osseointegration, the use of resin-based provisional crowns out of occlusion is recommended for immediate loading. Such protocols require several appointments and a significant contribution of the dentist and the lab technician, which affects overall treatment cost. On the other hand, CAD-CAM composites, especially Polymer-Infiltrated Ceramic Network (PICN), are now competing with ceramics for definitive single-unit restorations, notably due to their better machinability (faster and in lower-thickness milling, with les edge chipping) (3) (4), the absence of post-milling firing and the ease of in-mouth adjustments. In particular, their higher resilience and lower elasticity modulus could indicate them for immediate loading of implants. Intraoral scanning (IOS) of single-unit implants right after surgery and the chair-side manufacturing of a PICN crown would allow delivery of a resilient final tooth on the same day. The aim of these two case reports is to describe, as a technical note, an innovative approach for a straightforward and cost-effective replacement of a single missing tooth in the posterior region, as a proof of concept. [less ▲]

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See detailThe tails of the satellite auroral footprints at Jupiter
Bonfond, Bertrand ULiege; Saur, J.; Grodent, Denis ULiege et al

in Journal of Geophysical Research. Space Physics (2017), 122

The electro-magnetic interaction between Io, Europa and Ganymede and the rotating plasma that surrounds Jupiter has a signature in the aurora of the planet. This signature, called the satellite footprint ... [more ▼]

The electro-magnetic interaction between Io, Europa and Ganymede and the rotating plasma that surrounds Jupiter has a signature in the aurora of the planet. This signature, called the satellite footprint, takes the form of a series of spots located slightly downstream of the feet of the field lines passing through the moon under consideration. In the case of Io, these spots are also followed by an extended tail in the downstream direction relative to the plasma flow encountering the moon. A few examples of a tail for the Europa footprint have also been reported in the northern hemisphere. Here we present a simplified Alfvénic model for footprint tails and simulations of vertical brightness profiles for various electron distribution, which favour such a model over quasi-static models. We also report here additional cases of Europa footprint tails, in both hemispheres, even though such detections are rare and difficult. Furthermore, we show that the Ganymede footprint can also be followed by a similar tail. Finally, we present a case of a 320° long Io footprint tail, while other cases in similar configurations do not display such a length. [less ▲]

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See detailPhytosterols-induced viscoelasticity of oleogels prepared by using monoglycerides
Bin Sintang, M.D.; Danthine, Sabine ULiege; Brown, A. et al

in Food Research International (2017), 100

Monoglycerides (MGs) and phytosterols (PS) are known to form firm oleogels with liquid oil. However, the oleogels are prone to undergo polymorphic transition over time that lead to crystals' aggregation ... [more ▼]

Monoglycerides (MGs) and phytosterols (PS) are known to form firm oleogels with liquid oil. However, the oleogels are prone to undergo polymorphic transition over time that lead to crystals' aggregation thus, compromises physical properties. Thus, we combined MGs with PS to control the crystallization and modify the morphology of the combination oleogels, as both components are reported to interact together. The oleogels were prepared at different ratio combinations and characterized in their rheological, thermal, morphology, and diffraction properties. The results showed that the 8:2 MGP:PS exhibited higher storage modulus (G′) than the MGP mono-component. The combination oleogels exhibited effects on the crystallization and polymorphic transition. Consequently, the effects led to change in the morphology of the combination oleogels which was visualized using optical and electron microscope. The resultant effect on the morphology is associated with crystal defect. Due to observable crystals of MGP and PS, it is speculated that the combination oleogels formed a mixed crystal system. This was confirmed with diffraction analysis in which the corresponding peaks from MGP and PS were observed in the combination oleogels. However, the 8:2 oleogel exhibited additional peak at 35.41 Å. Ultimately, the 8:2 was the optimum combination observed in our study. Interestingly, this combination is inspired by nature as sterols (phytosterols) are natural component of lipid membrane whilst MGP has properties similar to phospholipids. Hence, the results of our study not only beneficial for oil structuring, but also for the fields of biophysical and pharmaceutical. [less ▲]

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See detailExperimental and numerical investigation of the nonlinear dynamics of compliant mechanisms for deployable structures
Dewalque, Florence ULiege; Schwartz, Cédric ULiege; Denoël, Vincent ULiege et al

in Mechanical Systems & Signal Processing (2017), 101

This paper studies the dynamics of tape springs which are characterised by a highly geometrical nonlinear behaviour including buckling, the formation of folds and hysteresis. An experimental set-up is ... [more ▼]

This paper studies the dynamics of tape springs which are characterised by a highly geometrical nonlinear behaviour including buckling, the formation of folds and hysteresis. An experimental set-up is designed to capture these complex nonlinear phenomena. The experimental data are acquired by the means of a 3D motion analysis system combined with a synchronised force plate. Deployment tests show that the motion can be divided into three phases characterised by different types of folds, frequencies of oscillation and damping behaviours. Furthermore, the reproducibility quality of the dynamic and quasi-static results is validated by performing a large number of tests. In parallel, a nonlinear finite element model is developed. The required model parameters are identified based on simple experimental tests such as static deformed configurations and small amplitude vibration tests. In the end, the model proves to be well correlated with the experimental results in opposite sense bending, while in equal sense, both the experimental set-up and the numerical model are particularly sensitive to the initial conditions. [less ▲]

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See detailExergy analysis applied to performance of buildings in Europe
Sartor, Kevin ULiege; Dewallef, Pierre ULiege

in Energy and Buildings (2017), 148

Energy performance of buildings generally assesses the energy consumption of buildings such as heating, domestic heat water, ventilation systems, etc. However, this approach is based on the first law of ... [more ▼]

Energy performance of buildings generally assesses the energy consumption of buildings such as heating, domestic heat water, ventilation systems, etc. However, this approach is based on the first law of thermodynamics and considers only the quantity of energy used without considering its ‘quality’ and leads to a lack of information about the energy conversion processes. This is particularly true in the new low-energy buildings where sometimes high temperatures sources are used to meet low-temperature needs. The exergy analysis of a system, based on first and second thermodynamic laws, can be used to overcome this. In this work, it is proposed to compare the energy and the exergy consumption and the related CO2 emissions of several kinds of buildings to determine the best systems in terms of energy and exergy needs. The energy demand calculations are performed using the official software available in Belgium and some assumptions are implemented to consider the exergy approach. As exergy calculations require a reference state, some different climatic conditions are also investigated. Finally, some conclusions are discussed to rank the sources of energy and their related exergy losses. [less ▲]

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See detailThe inner structure of early-type galaxies in the Illustris simulation
Xu, Dandan; Springel, Volker; Sluse, Dominique ULiege et al

in Monthly Notices of the Royal Astronomical Society (2017), 469

Early-type galaxies provide unique tests for the predictions of the cold dark matter cosmology and the baryonic physics assumptions entering models for galaxy formation. In this work, we use the Illustris ... [more ▼]

Early-type galaxies provide unique tests for the predictions of the cold dark matter cosmology and the baryonic physics assumptions entering models for galaxy formation. In this work, we use the Illustris simulation to study correlations of three main properties of early-type galaxies, namely the stellar orbital anisotropies, the central dark matter fractions and the central radial density slopes, as well as their redshift evolution since z = 1.0. We find that lower mass galaxies or galaxies at higher redshift tend to be bluer in rest-frame colour, have higher central gas fractions, and feature more tangentially anisotropic orbits and steeper central density slopes than their higher mass or lower redshift counterparts, respectively. The projected central dark matter fraction within the effective radius shows a very mild mass dependence but positively correlates with galaxy effective radii due to the aperture effect. The central density slopes obtained by combining strong lensing measurements with single-aperture kinematics are found to differ from the true density slopes. We identify systematic biases in this measurement to be due to two common modelling assumptions, isotropic stellar orbital distributions and power-law density profiles. We also compare the properties of early-type galaxies in Illustris to those from existing galaxy and strong lensing surveys; we find in general broad agreement but also some tension, which poses a potential challenge to the stellar formation and feedback models adopted by the simulation. [less ▲]

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See detailA New Solar Spectrum from 656 to 3088 nm
Meftah, M.; Damé, L.; Bolsée, D. et al

in Solar Physics (2017), 292

The solar spectrum is a key parameter for different scientific disciplines such as solar physics, climate research, and atmospheric physics. The SOLar SPECtrometer (SOLSPEC) instrument of the Solar ... [more ▼]

The solar spectrum is a key parameter for different scientific disciplines such as solar physics, climate research, and atmospheric physics. The SOLar SPECtrometer (SOLSPEC) instrument of the Solar Monitoring Observatory (SOLAR) payload onboard the International Space Station (ISS) has been built to measure the solar spectral irradiance (SSI) from 165 to 3088 nm with high accuracy. To cover the full wavelength range, three double-monochromators with concave gratings are used. We present here a thorough analysis of the data from the third channel/double-monochromator, which covers the spectral range between 656 and 3088 nm. A new reference solar spectrum is therefore obtained in this mainly infrared wavelength range (656 to 3088 nm); it uses an absolute preflight calibration performed with the blackbody of the Physikalisch-Technische Bundesanstalt (PTB). An improved correction of temperature effects is also applied to the measurements using in-flight housekeeping temperature data of the instrument. The new solar spectrum (SOLAR-IR) is in good agreement with the ATmospheric Laboratory for Applications and Science (ATLAS 3) reference solar spectrum from 656 nm to about 1600 nm. However, above 1600 nm, it agrees better with solar reconstruction models than with spacecraft measurements. The new SOLAR/SOLSPEC measurement of solar spectral irradiance at about 1600 nm, corresponding to the minimum opacity of the solar photosphere, is 248.08 ± 4.98 mW m[SUP]-2[/SUP] nm[SUP]-1[/SUP] (1 σ), which is higher than recent ground-based evaluations. [less ▲]

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See detailThe EBLM project. III. A Saturn-size low-mass star at the hydrogen-burning limit
von Boetticher, Alexander; Triaud, Amaury H. M. J.; Queloz, Didier et al

in Astronomy and Astrophysics (2017), 604

We report the discovery of an eclipsing binary system with mass-ratio q ˜ 0.07. After identifying a periodic photometric signal received by WASP, we obtained CORALIE spectroscopic radial velocities and ... [more ▼]

We report the discovery of an eclipsing binary system with mass-ratio q ˜ 0.07. After identifying a periodic photometric signal received by WASP, we obtained CORALIE spectroscopic radial velocities and follow-up light curves with the Euler and TRAPPIST telescopes. From a joint fit of these data we determine that EBLM J0555-57 consists of a sun-like primary star that is eclipsed by a low-mass companion, on a weakly eccentric 7.8-day orbit. Using a mass estimate for the primary star derived from stellar models, we determine a companion mass of 85 ± 4 M[SUB]Jup[/SUB] (0.081 M[SUB]⊙[/SUB]) and a radius of 0.84[SUP]+ 0.14[/SUP][SUB]-0.04[/SUB]R[SUB]Jup[/SUB] (0.084 R[SUB]⊙[/SUB]) that is comparable to that of Saturn. EBLM J0555-57Ab has a surface gravity log g[SUB]2[/SUB] =5.50[SUP]+ 0.03[/SUP][SUB]-0.13[/SUB] and is one of the densest non-stellar-remnant objects currently known. These measurements are consistent with models of low-mass stars. The photometry tables and radial velocities are only available at the CDS and on demand via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (<A href="http://130.79.128.5">http://130.79.128.5</A>) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/604/L6">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/604/L6</A> [less ▲]

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See detailSocial sustainability assessments in the biobased economy: Towards a systemic approach
Rafiaani, Parisa ULiege; Kuppens, Tom; Van Dael, Miet et al

in Renewable & Sustainable Energy Reviews (2017)

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a ... [more ▼]

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a modified systemic approach for a social sustainability impact assessment of the biobased economy, based on a review on the common methodologies for assessing social impacts. Accordingly, the proposed approach follows the four general iterative steps of social life cycle analysis (SLCA) as it considers all life cycle phases of the biobased economy. The systemic approach considers the potential social impacts on local communities, workers, and consumers as the main three groups of the stakeholders. The review showed that the most common social indicators for inventory analysis within the biobased economy include health and safety, food security, income, employment, land- and worker-related concerns, energy security, profitability, and gender issues. Multi-criteria decision analysis (MCDA) was also highlighted as the broadly utilized methodology for aggregating the results of impact assessments within the biobased economy. Taking a life cycle perspective, this study provides a holistic view of the full sustainability of research, design, and innovation in the biobased economy by suggesting the integration of the social aspects with techno-economic and an environmental life cycle assessment. Our proposed systemic approach makes possible to integrate the social impacts that are highly valued by the affected stakeholders into the existing sustainability models that focus only on environmental and techno-economic aspects. We discuss the steps of the proposed systemic approach in order to identify the challenges of applying them within the biobased economy. These challenges refer mainly to the definition of the functional unit and system boundaries, the selection and the analysis of social indicators (inventory analysis), the aggregation of the inventory to impact categories, and the uncertainties associated with the social sustainability evaluation. The result of this review and the proposed systemic approach serve as a foundation for industry and policy makers to gain a better insight into the importance of social sustainability impacts assessment within the biobased economy. [less ▲]

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See detailThe Far Ultra-Violet Imager on the Icon Mission
Mende, Stephen; Frey, Harald; Rider, Kodi et al

in Space Science Reviews (2017)

ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime atmosphere/ ionosphere. During sunlit atmospheric ... [more ▼]

ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime atmosphere/ ionosphere. During sunlit atmospheric conditions, ICON FUV images the limb altitude profile in the shortwave (SW) band at 135.6 nm and the longwave (LW) band at 157 nm perpendicular to the satellite motion to retrieve the atmospheric O/N2 ratio. In conditions of atmospheric darkness, ICON FUV measures the 135.6 nm recombination emission of O+ ions used to compute the nighttime ionospheric altitude distribution. ICON Far Ultra- Violet (FUV) imager is a Czerny–Turner design Spectrographic Imager with two exit slits and corresponding back imager cameras that produce two independent images in separate wavelength bands on two detectors. All observations will be processed as limb altitude profiles. In addition, the ionospheric 135.6 nm data will be processed as longitude and latitude spatial maps to obtain images of ion distributions around regions of equatorial spread F. The ICON FUV optic axis is pointed 20 degrees below local horizontal and has a steering mirror that allows the field of view to be steered up to 30 degrees forward and aft, to keep the local magnetic meridian in the field of view. The detectors are micro channel plate (MCP) intensified FUV tubes with the phosphor fiber-optically coupled to Charge Coupled Devices (CCDs). The dual stack MCP-s amplify the photoelectron signals to overcome the CCD noise and the rapidly scanned frames are co-added to digitally create 12-second integrated images. Digital on-board signal processing is used to compensate for geometric distortion and satellite motion and to achieve data compression. The instrument was originally aligned in visible light by using a special grating and visible cameras. Final alignment, functional and environmental testing and calibration were performed in a large vacuum chamber with a UV source. The test and calibration program showed that ICON FUV meets its design requirements and is ready to be launched on the ICON spacecraft. [less ▲]

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See detailLe rôle des petites entreprises du métier artisanal traditionnel dans le développement local: case d'étude dans le périphérie de Hanoi
Nguyen, Thi Thu Hien ULiege; Lebailly, Philippe ULiege; Nguyen, Van Nghien

in Science and Technology Journal of Agriculture & Rural Development (2017), 15

Rural industrial development and new rural development programmes are the main target of Vietnam in the process of industrialization – modernization of the country. To expedite this process, it is ... [more ▼]

Rural industrial development and new rural development programmes are the main target of Vietnam in the process of industrialization – modernization of the country. To expedite this process, it is necessary to promote the development and encourage the contributions of small enterprise in general and small enterprise rural in particular because practices in many countries show the important role of small and micro enterprises in local development. This paper presents the initial results of research to understand the economic–social contributions of rural enterprises to local development through the mobilization of local resources as well as establishment of the economic-social relations in local of rattan’s enterprises in the suburb of Hanoi, and then propose some measures to facilitate the operation of enterprises and promote the contribution of rattan’s enterprises for local development. [less ▲]

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See detailRoom temperature ferroelectricity in fluoroperovskite thin films
Ming Yang, Amit KC; García Castro, Andrès Camilo ULiege; Borisov, Pavel et al

in Scientific Reports (2017), 7

The NaMnF3 fluoride-perovskite has been found, theoretically, to be ferroelectric under epitaxial strain becoming a promising alternative to conventional oxides for multiferroic applications. Nevertheless ... [more ▼]

The NaMnF3 fluoride-perovskite has been found, theoretically, to be ferroelectric under epitaxial strain becoming a promising alternative to conventional oxides for multiferroic applications. Nevertheless, this fluoroperovskite has not been experimentally verified to be ferroelectric so far. Here we report signatures of room temperature ferroelectricity observed in perovskite NaMnF3 thin films grown on SrTiO3. Using piezoresponse force microscopy, we studied the evolution of ferroelectric polarization in response to external and built-in electric fields. Density functional theory calculations were also performed to help understand the strong competition between ferroelectric and paraelectric phases as well as the profound influences of strain. These results, together with the magnetic order previously reported in the same material, pave the way to future multiferroic and magnetoelectric investigations in fluoroperovskites. [less ▲]

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See detailLa place des savoirs grammaticaux et lexicaux dans les référentiels de compétences (1999-2016) et dans certains manuels de langues modernes
Simons, Germain ULiege; Delbrassine, Daniel ULiege; Van Hoof, Florence ULiege et al

in Didactiques en pratique (2017), 3

Cet article propose d'abord une lecture critique des référentiels de langues modernes qui ont été en vigueur en Communauté française de Belgique entre 1999 et 2016. Y sont principalement analysés les ... [more ▼]

Cet article propose d'abord une lecture critique des référentiels de langues modernes qui ont été en vigueur en Communauté française de Belgique entre 1999 et 2016. Y sont principalement analysés les référentiels "Socles de compétences en langues modernes" et "Compétences terminales et savoirs requis en langues modernes". La deuxième partie de l'article porte sur l'analyse partielle de deux manuels, le "Nieuwe Tandem 2" et le "New Headway". Une des thèses des auteurs de l'article est que ces référentiels de compétences et ces supports didactiques peuvent accroître l'hétérogénéité des niveaux de maîtrise en langue et générer des inégalités dans l'apprentissage. L'article se termine en évoquant différentes pistes qui peuvent contribuer à limiter les risques identifiés. [less ▲]

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See detailEnergy Dissipation Within the Wave Run-Up at Stepped Revetments
Kerpen, Nils B.; Bung, Daniel B.; Valero Huerta, Daniel ULiege et al

in Journal of Ocean University of China (2017), 16(4), 649-654

To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment, hydraulic model tests with steady flow conditions are conducted and ... [more ▼]

To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment, hydraulic model tests with steady flow conditions are conducted and correlated with unsteady flow conditions of the wave run-up within a short time frame. Under irregular waves, the run-up reduction over a stepped revetment is dependent on the Iribarren number and decreases for decreasing Iribarren numbers. Velocity gradients are found to be similar in a steady and unsteady flow regime near the pseudo-bottom. [less ▲]

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See detailChemical abundances of fast-rotating massive stars. II. Interpretation and comparison with evolutionary models
Cazorla, Constantin ULiege; Nazé, Yaël ULiege; Morel, Thierry ULiege et al

in Astronomy and Astrophysics (2017), 604(A123),

Aims: Past observations of fast-rotating massive stars exhibiting normal nitrogen abundances at their surface have raised questions about the rotational mixing paradigm. We revisit this question thanks to ... [more ▼]

Aims: Past observations of fast-rotating massive stars exhibiting normal nitrogen abundances at their surface have raised questions about the rotational mixing paradigm. We revisit this question thanks to a spectroscopic analysis of a sample of bright fast-rotating OB stars, with the goal of quantifying the efficiency of rotational mixing at high rotation rates. Methods: Our sample consists of 40 fast rotators on the main sequence, with spectral types comprised between B0.5 and O4. We compare the abundances of some key element indicators of mixing (He, CNO) with the predictions of evolutionary models for single objects and for stars in interacting binary systems. Results: The properties of half of the sample stars can be reproduced by single evolutionary models, even in the case of probable or confirmed binaries that can therefore be true single stars in a pre-interaction configuration. The main problem for the rest of the sample is a mismatch for the [N/O] abundance ratio (we confirm the existence of fast rotators with a lack of nitrogen enrichment) and/or a high helium abundance that cannot be accounted for by models. Modifying the diffusion coefficient implemented in single- star models does not solve the problem as it cannot simultaneously reproduce the helium abundances and [N/O] abundance ratios of our targets. Since part of them actually are binaries, we also compared their chemical properties with predictions for post-mass transfer systems. We found that these models can explain the abundances measured for a majority of our targets, including some of the most helium-enriched, but fail to reproduce them in other cases. Our study thus reveals that some physical ingredients are still missing in current models. [less ▲]

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See detailChondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Sanchez, Christelle ULiege; Bay-Jensen, Anne-Christine; Pap, Thomas et al

in Osteoarthritis and Cartilage (2017), 25

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See detailSimilarity of the Jovian satellite footprints: spots multiplicity and dynamics
Bonfond, Bertrand ULiege; Grodent, Denis ULiege; Badman, S. V. et al

in Icarus (2017), 292(2017), 208217

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the ... [more ▼]

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the planet. Called satellite footprints, these auroral features appear either as a single spot (Europa and Enceladus) or as multiple spots (Io and Ganymede). Moreover, they can be followed by extended trailing tails in the case of Io and Europa, while no tail has been reported for Ganymede and Enceladus, yet. Here we show that all Jovian footprints can be made of several spots. Furthermore, the footprints all experience brightness variations on timescale of 2-3 minutes. We also demonstrate that the satellite location relative to the plasma sheet is not the only driver for the footprint brightness, but that the plasma environment and the magnetic field strength also play a role. These new findings demonstrate that the Europa and Ganymede footprints are very similar to the Io footprint. As a consequence, the processes expected to take place at Io, such as the bi-directional electron acceleration by Alfvén waves or the partial reflection of these waves on plasma density gradients, can most likely be extended to the other footprints, suggesting that they are indeed universal processes. [less ▲]

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See detailOrganometallic-mediated alternating radical copolymerization of tert-butyl-2- trifluoromethacrylate with vinyl acetate and synthesis of block copolymers thereof
Banerjee, Sanjib; Ladmiral, Vincent; Debuigne, Antoine ULiege et al

in Macromolecular Rapid Communications (2017), 38(15), 1700203

Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE ... [more ▼]

Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE) copolymers composed of two electronically distinct monomers: vinyl acetate (VAc, donor, D) and tert-butyl-2-trifluoromethacrylate (MAF-TBE, acceptor, A), with low dispersity (≤1.24) and molar masses up to 57 000 g mol−1. These copolymers have a precise 1:1 alternating structure over a wide range of comonomer feed compositions. The reactivity ratios are determined as rVAc = 0.01 ± 0.01 and rMAF-TBE = 0 at 40 °C. Remarkably, from a feed containing >50% molar VAc content, poly(VAc-alt-MAF-TBE)-b- PVAc block copolymers are produced via a one- pot synthesis. Such diblock copolymers exhibit two glass transition temperatures attributed to the alternating and homopolymer sequences. The OMRP of this fluorine-containing alter- nating monomer system may provide access to a wide range of new polymer materials. [less ▲]

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See detailHydrothermal synthesis in presence of carbon black: Particle-size reduction of iron hydroxyl phosphate hydrate for Li-ion battery
Karegeya, Claude ULiege; Mahmoud, Abdelfattah ULiege; Cloots, Rudi ULiege et al

in Electrochimica Acta (2017), 250

Iron hydroxyl phosphate hydrate Fe1.19(PO4)(OH)0.57(H2O)0.43 (FPHH) was obtained by hydrothermal synthesis at 220 °C for 6 hours. Addition of carbon black to the solution before hydrothermal treatment led ... [more ▼]

Iron hydroxyl phosphate hydrate Fe1.19(PO4)(OH)0.57(H2O)0.43 (FPHH) was obtained by hydrothermal synthesis at 220 °C for 6 hours. Addition of carbon black to the solution before hydrothermal treatment led to a reduction of the FPHH particle size from ∼10 μm in the carbon-free compound to ∼300–500 nm in the FPHH-10%C and FPHH-20%C composite with a good dispersion of conducting carbon black. X-ray diffraction, 57Fe Mossbauer spectroscopy and a thermal decomposition study showed that the addition of carbon black did not interfere with the formation of the FPHH phase. Thanks to its favorable microstructural characteristics, the FPHH-10%C and FPHH-20%C material exhibited good performance as positive electrode for Li-ion battery, with high initial discharge capacities of 150, 128 and 112 mAh g−1 at 0.25C, 0.5C and 1C rates respectively and 99% capacity retention after 150 cycles at 2C. These results show that addition of solid carbon directly into the solution prior to hydrothermal treatment is a simple and effective way to reduce particle size and also to improve electronic conductivity by dispersing conductive carbon around the active material. This approach is easily transferable to other compounds prepared by hydrothermal synthesis, in order to control particle size while retaining the advantage of crystallization at low temperature. [less ▲]

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See detailA fast and simple method for simultaneous measurements of 25(OH)D, 24,25(OH)2D and the Vitamin D Metabolite Ratio (VMR) in serum samples by LC-MS/MS
Fabregat Cabello, Neus ULiege; Farre Segura, Jordi ULiege; Huyghebaert, Loreen ULiege et al

in Clinica Chimica Acta (2017)

BACKGROUND: Rapid, easy and reliable measurement of the major vitamin D metabolites is required in order to fulfill the needs of a clinical routine laboratory. To overcome these challenges, we have ... [more ▼]

BACKGROUND: Rapid, easy and reliable measurement of the major vitamin D metabolites is required in order to fulfill the needs of a clinical routine laboratory. To overcome these challenges, we have developed and validated a LC-MS/MS method for the quantification of 25-hydroxyvitamin D2 and D3, epi-25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. METHODS: Sample preparation was based on precipitation and centrifugation of 100 µL of patient serum, followed by injection into the LC-MS/MS system. Samples from Vitamin D Standardization Program (n=80) and patient samples (n=281) have been compared with a reference LC-MS/MS method. For the analytical validation NIST and Labquality quality control materials were used. RESULTS: Mean intra-assay and inter-assay imprecision were less than 6.0 and 6.4% and mean recoveries were within 95-104%. LOQ’s were 0.5 µg/L for 24,25(OH)2D3, 1.1 µg/L for 25(OH)D3 and epi-25(OH)D3 and 1.7 µg/L for 25(OH)D2. A 3% bias obtained between the proposed and the reference method satisfies Vitamin D Standardization Program recommendations. CONCLUSIONS: We present a rapid, easy, reliable and cost-effective method completely adequate for routine testing, which permits the measurement of the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D, Vitamin D Metabolite Ratio (VMR), in serum samples. [less ▲]

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See detailRight-sided pulmonary venous return to the inferior vena cava: an exceptional malformation.
Ellouze, Nesrine; Farhat, Nesrine; Desprechins, Brigitte ULiege et al

in Acta Cardiologica (2017), 72(4), 489-490

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See detailAdministration of mesenchymal stromal cells before renal ischemia/reperfusion attenuates kidney injury and may modulate renal lipid metabolism in rats.
ERPICUM, Pauline ULiege; Rowart, Pascal ULiege; POMA, Laurence ULiege et al

in Scientific Reports (2017), 7(1), 8687

Mesenchymal stromal cells (MSC) have been demonstrated to attenuate renal ischemia/reperfusion (I/R) damage in rodent models. The mechanisms of such nephro-protection remain largely unknown. Furthermore ... [more ▼]

Mesenchymal stromal cells (MSC) have been demonstrated to attenuate renal ischemia/reperfusion (I/R) damage in rodent models. The mechanisms of such nephro-protection remain largely unknown. Furthermore, the optimal timing of MSC administration has been poorly investigated. Here, we compare the impact of MSC injection 7 days before (MSCD - 7) versus 1 day after (MSCD + 1) renal I/R in rats. Control groups received equivalent volumes of saline at similar time-points (SD - 7 and SD + 1). Right nephrectomy was performed, and left renal ischemia lasted 45 min. After 48-hour reperfusion, we observed significantly improved renal function parameters, reduced apoptotic index and neutrophil/macrophage infiltration in kidney parenchyma, and lower expression of tubular damage markers and pro-inflammatory cytokines in MSCD - 7 in comparison to MSCD + 1 and saline control groups. Next, comparative high-throughput RNA sequencing of MSCD - 7 vs. SD - 7 non-ischemic right kidneys highlighted significant down-regulation of fatty acid biosynthesis and up-regulation of PPAR-alpha pathway. Such a preferential regulation towards lipid catabolism was associated with decreased levels of lipid peroxidation products, i.e. malondialdehyde and 4-hydroxy-2-nonenal, in MSCD - 7 versus SD - 7 ischemic kidneys. Our findings suggest that MSC pretreatment may exert protective effects against renal I/R by modulating lipid metabolism in rats. [less ▲]

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See detailEYK1 encoding erythrulose kinase as a catabolic selectable marker for genome editing in the non-conventional yeast Yarrowia lipolytica
Vandermies, Marie ULiege; Denies, Olivia ULiege; Nicaud, Jean-Marc et al

in Journal of Microbiological Methods (2017), 139

We report here on EYK1, encoding erythrulose kinase, as an efficient catabolic selectable marker for genome editing in Y. lipolytica. Compared to auxotrophic markers, EYK1 increases the growth rate of ... [more ▼]

We report here on EYK1, encoding erythrulose kinase, as an efficient catabolic selectable marker for genome editing in Y. lipolytica. Compared to auxotrophic markers, EYK1 increases the growth rate of transformants and allows improved efficiency of transformation. The utility of the marker EYK1 in a replicative vector was also demonstrated. [less ▲]

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See detail« Oser sauver à l’école » : Mise en place d’un cycle de premier secours au cours d’éducation physique
Collin, Manon ULiege; Cloes, Marc ULiege; Laurent, Charlotte et al

in Didactiques en Pratique (2017), 3

En Europe et aux États-Unis, plus de 700 000 personnes décèdent chaque année des suites d’un arrêt cardiaque (Berdowski et al. 2010). Avec un taux de survie de 2 à 10 % (European Resuscitation Council ... [more ▼]

En Europe et aux États-Unis, plus de 700 000 personnes décèdent chaque année des suites d’un arrêt cardiaque (Berdowski et al. 2010). Avec un taux de survie de 2 à 10 % (European Resuscitation Council, 2015), le pronostic vital associé aux arrêts cardiaques est, dès lors, relativement limité. Celui-ci peut être cinq à sept fois supérieur si un témoin pratique une réanimation cardio-pulmonaire (RCP) et une défibrillation durant les premières minutes d’intervention (ERC, 2015). Dans le cadre de cette étude pilote, l’objectif était d’analyser la pertinence, l’impact et la faisabilité de la mise en place d’un cycle de premiers secours dans un contexte scolaire, et, plus particulièrement, dans le programme du cours d’éducation physique. Le cycle, d'une durée de 6 semaines (6 x 50 minutes), a été dispensé à deux classes de rhétoriques (n=51). Les compétences des élèves ont été évaluées à l'aide d'un questionnaire avant et après le cycle, ainsi qu'une grille d'observation évaluant les habiletés gestuelles des élèves lors d'un protocole complet de réanimation de base d’une personne adulte avec un DEA. La moyenne des résultats des élèves au questionnaire est passée de 6,12 ± 3,25/20 (0,5-14) lors du pré-test à 17,32 ± 1,79 /20 (10,5-20) à l’issue du cycle (p=0,00). La moyenne au test pratique est de 17,16 ± 1,72/20 (13,66-20). La séquence de cours proposée a permis d’améliorer les connaissances théoriques des élèves, leurs habiletés gestuelles et leur confiance par rapport à leur capacité à porter secours à une victime d’un arrêt cardiaque, et s'inscrit clairement dans la philosophie du Pacte pour un Enseignement d’Excellence. [less ▲]

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See detailComprehensive study of the drying behavior of Boom clay:Experimental investigation and numerical modeling
Hubert, Julien ULiege; Plougonven, Erwan ULiege; Prime, Noémie et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2017)

This paper presents a thermo-hydro-mechanical framework to model the dryingbehavior of Boom clay. First, the experimental campaign conducted Noémie Primeis briefly presented because it is used to validate ... [more ▼]

This paper presents a thermo-hydro-mechanical framework to model the dryingbehavior of Boom clay. First, the experimental campaign conducted Noémie Primeis briefly presented because it is used to validate the model. The data acquisitionand processing is emphasized because of the use of X-ray microtomography to beable to more accurately compare experimental and numerical strain fields. The dif-ferent submodels are introduced. Numerical simulations are performed to illustratethe capability of the proposed model to reproduce the observed behavior. Finally,a comprehensive sensitivity study on several key model parameters associated withthe water retention curve, and the permeability of the medium, is performed to get abetter understanding of the physics behind the coupled model. [less ▲]

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See detailRegiospecific radiolabelling of Nanofitin on Ni Magnetic Beads with [18F]FBEM and in vivo PET studies
Dammicco, Sylvestre ULiege; Goux, Marine; Lemaire, Christian ULiege et al

in Nuclear Medicine & Biology (2017)

Introduction: Nanofitins are low molecular weight, single chain and cysteine-free protein scaffolds able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family ... [more ▼]

Introduction: Nanofitins are low molecular weight, single chain and cysteine-free protein scaffolds able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family and are highly stable over a wide range of pH (0-13) and temperature (Tm ~80°C). Their extreme stability, low cost of production and high tolerability for chemical coupling make Nanofitins a very interesting alternative to antibodies and their fragments. Here, a hexahistidine tagged model Nanofitin (H4) directed against hen egg white lysozyme was radiolabelled and injected in mice to provide a baseline biodistribution and pharmacokinetic profiles to support future Nanofitin development programs. Method: A single cysteine residue has been genetically inserted in a model Nanofitin and its regioselective radiolabelling has been performed with 4-[18F]fluorobenzamido-N-ethylamino-maleimide ([18F]FBEM). The synthesis of [18F]FBEM has been completely implemented on a radiosynthesis unit (FastLab) including HPLC purification and formulation. Coupling with the [18F]FBEM has been achieved on a solid support (Ni magnetic beads) allowing rapid purification at room temperature without organic solvent. PET-MRI studies on C57BL/6 mice were conducted after injection of [18F]FBEM-Cys-H4 in order to access the biodistribution of this Nanofitin model. Results: Radiochemical yield (decay corrected) of 54±7% (n=4) was obtained after optimization for coupling the [18F]FBEM to Nanofitin. Pharmacokinetics results of [18F]FBEM-Cys-H4 revealed a fast clearance through the liver and the kidneys. Conclusion: An efficient new method on Ni magnetic beads was developed to radiolabelled his-tagged biomolecules with [18F]FBEM. This procedure was applied on a Nanofitin model Cys-H4 and biodistribution kinetic studies were achieved to evaluate the potential use of Nanofitin for diagnostic imaging. Fast clearance indicates that Nanofitins represent very interesting tools for diagnostic imaging. [less ▲]

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See detailInnovative polyelectrolytes/poly(ionic liquid)s for energy and environment
Ajjan, Fátima N.; Ambrogi, Martina; Tiruye, Girum Ayalneh et al

in Polymer International (2017), 66(8), 1119-1126

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications ... [more ▼]

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications. Within the project different types of innovative polyelectrolytes were synthesized such as poly(ionic liquid)s coming from renewable or natural ions, thiazolium cations, cathechol functionalities or from a new generation of cheap deep-eutectic monomers. Further, macromolecular architectures such as new poly(ionic liquid) block copolymers and new (semi)conducting polymer/polyelectrolyte complexes were also developed. As the final goal, the application of these innovative polymers in energy and environment was investigated. Important advances in energy storage technologies included the development of new carbonaceous materials, new lignin/conducting polymer biopolymer electrodes, new iongels and single-ion conducting polymer electrolytes for supercapacitors and batteries and new poly(ionic liquid) binders for batteries. On the other hand, the use of the innovative polyelectrolytes into sustainable environmental technologies led to the development of new liquid and dry water, new materials for water cleaning technologies such as floculants, oil absorbers, new recyclable organocatalysts platform and multifunctional polymer coatings with antifouling and antimicrobial properties. All in all this article demonstrates the potential of the poly(ionic liquid)s for high-value applications in Energy & Enviromental areas. [less ▲]

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See detailAnalysis of the non-Markovianity for electron transfer reactions in the oligothiophene-fullerene in an heterojunction
Mangaud, Etienne; Meier, Christoph; Desouter, Michèle ULiege

in Chemical Physics (2017), 494

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See detailLe flâneur et l'ethnographe. Sur le savoir des Physiologies
Stienon, Valérie ULiege

in La Licorne (2017)

Les Physiologies parues dans la première moitié du XIXe siècle dans la presse satirique illustrée et les collections des éditeurs de pittoresques livrent un certain savoir sur la société parisienne de la ... [more ▼]

Les Physiologies parues dans la première moitié du XIXe siècle dans la presse satirique illustrée et les collections des éditeurs de pittoresques livrent un certain savoir sur la société parisienne de la Monarchie de Juillet. Elles le font en situant les contemporains dans leur biotope métropolitain et en pratiquant des formes de microsociologie par consignation des us et coutumes saisis à travers le prisme de l’observation quotidienne in situ. De ce point de vue, ces textes semblent proches de documents d’ethnographie critique, si on conçoit l’ethnographie comme la discipline qui s’occupe de la collecte sur le terrain de données anthropologiques et sociales. Ce geste ethnographique a pu être préparé par la rencontre du regard du clinicien sur le social et du réflexe classificateur du naturaliste auxquels s’ajoutent des données factuelles historiques : l’anthropologie française se développe à Paris dès 1799, suite à la découverte de l’enfant sauvage de l’Aveyron, avec la Société des observateurs de l’homme. Si celle-ci est dissoute très tôt, en 1804, d’autres groupements prennent le relais et, en 1839, la Société ethnologique est créée à Paris. Revenant sur le contexte qui prépare la naissance des disciplines ethnologique et sociologique, cette étude propose de croiser les scénographies énonciatives de l’ethnographe mises en œuvre dans les Physiologies à une autre figure du savoir en déambulation qu’elles thématisent abondamment, celle du flâneur, pour déterminer leurs généalogies littéraires et leurs apports respectifs au savoir (pré)sociologique manifesté par ces textes dans leur poétique d’écriture situable entre presse engagée, littérature et sciences du vivant. [less ▲]

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See detailResponders to platelet-rich plasma (PRP) in osteoarthritis: A technical analysis
MILANTS, Christophe ULiege; Bruyère, Olivier ULiege; Kaux, Jean-François ULiege

in BioMed Research International (2017)

Purpose. To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee ... [more ▼]

Purpose. To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. Materials and Methods. A comparison of the outcomes of randomized controlled trials (RCTs) included in the 3 most recent and high-quality meta-analyses to classify the different studies in 2 groups (bad responders group (BRG) and very good responders group (VGRG)). Results and Discussion. From the 19 RCTs analyzed, 7 trials were included in the VGRG and 4 in the BRG. In VGRG, 1 or 2 injections were performed in 4/7 trials, time between injections was 2 to 3 weeks in 4/5 studies with many injections, volume injected varied from 2.5 to 8 mL, and single spinning technique was used in 5/7 studies. PRP classification was Mishra 4B and PAWP2B𝛽 in 5/7 studies. The use of PRP with leukocytes is only found in the BRG. Conclusion. There is a lack of standardization in PRP preparation technique for knee osteoarthritis. However it appears that the use of a single spinning technique, a platelet concentration lower than 5 times the baseline, and avoidance of leukocytes should be preferred. [less ▲]

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See detailCombining semi-automated image analysis techniques with machine learning algorithms to accelerate large scale genetic studies
Atkinson, Jonathan; Lobet, Guillaume; Noll, Manuel ULiege et al

in GigaScience (2017)

Background: Genetic analyses of plant root systems require large datasets of extracted architectural traits. To quantify such traits from images of root systems, researchers often have to choose between ... [more ▼]

Background: Genetic analyses of plant root systems require large datasets of extracted architectural traits. To quantify such traits from images of root systems, researchers often have to choose between automated tools (that are prone to error and extract only a limited number of architectural traits) or semi-automated ones (that are highly time consuming). Findings: We trained a Random Forest algorithm to infer architectural traits from automatically extracted image descriptors. The training was performed on a subset of the dataset, then applied to its entirety. This strategy allowed us to (i) decrease the image analysis time by 73% and (ii) extract meaningful architectural traits based on image descriptors. We also show that these traits are sufficient to identify Quantitative Trait Loci that had previously been discovered using a semi-automated method. Conclusions: We have shown that combining semi-automated image analysis with machine learning algorithms has the power to increase the throughput of large scale root studies. We expect that such an approach will enable the quantification of more complex root systems for genetic studies. We also believe that our approach could be extended to other areas of plant phenotyping. [less ▲]

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See detailAssessment of Continuous Pain in Newborns admitted to NICUs in 18 European Countries
Anand, Kanwaljeet; Eriksson, Mats; Boyle, Elaine et al

in Acta Paediatrica (2017), 106(8), 1248-59

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A ... [more ▼]

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A prospective cohort study in 243 Neonatal Intensive Care Units (NICUs) from 18 European countries recorded frequency of pain assessments, use of mechanical ventilation, sedation, analgesia, or neuromuscular blockade for each neonate upto 28 days after NICU admission. Results: Only 2113/6648 (31·8%) of neonates received assessments of continuous pain, occurring variably among tracheal ventilation (TrV, 46·0%), noninvasive ventilation (NiV, 35· 0%), and no ventilation (NoV, 20· 1%) groups (p<0· 001). Daily assessments for continuous pain occurred in only 10·4% of all neonates (TrV: 14· 0%, NiV: 10· 7%, NoV: 7· 6%; p<0· 001). More frequent assessments of continuous pain occurred in NICUs with pain guidelines, nursing champions, and surgical admissions prompted (all p<0·01), and for newborns <32 weeks gestational age, those requiring ventilation, or opioids, sedatives-hypnotics, general anesthetics (O-SH-GA) (all p<0·001), or surgery (p=0· 028). Use of O-SH-GA drugs increased the odds for pain assessment in the TrV (OR:1· 60, p<0·001) and NiV groups (OR:1·40, p<0· 001). Conclusion: Assessments of continuous pain occurred in less than one-third of NICU admissions, and daily in only 10% of neonates. NICU clinical practices should consider including routine assessments of continuous pain in newborns. [less ▲]

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See detailCan electoral inequalities be legally justified?
Bouhon, Frédéric ULiege

in European Review of Public Law (2017), 2016(Automn), 839-879

In light of the principle of equality, German, Belgian and British election law contain some legal rules that tend to distribute the faculty to influence the composition of the elected assemblies equally ... [more ▼]

In light of the principle of equality, German, Belgian and British election law contain some legal rules that tend to distribute the faculty to influence the composition of the elected assemblies equally among the governed people, and others that tend to distribute it unequally. The inequality caused by the latter group may be to some extent legally justified by concerns for the general interest, but also provides rulers with means that help them to remain in power, which is hardly justifiable from a legal perspective. In these legal systems, parties are expected to gain a significant portion of the people’s support: not only should the parliament (as a whole) and its members (as individuals) represent the governed people, but the parties themselves are expected to be sufficiently representative of the people in order to access the legislative assemblies. Notably, this thesis draws examples from the case law of the European Court of Human Rights, from which relevant decisions are mentioned here. [less ▲]

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See detailRADIONUCLIDE IMAGING OF INFECTIVE ENDOCARDITIS: state of art and future perspective
MARCHETTA, Stella ULiege; WITHOFS, Nadia ULiege; ERBA, Paola Anna et al

in Current Cardiovascular Imaging Reports (2017), 10(27),

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See detailLa difficile jointure des directives EU anti-BEPS et des traités fiscaux
Docclo, Caroline ULiege

in Fiscologue International = Fiscoloog internationaal (2017)

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See detailCation Distribution Dependent Magnetic Properties in CoCr 2-x Fe x O 4 (x= 0.1 to 0.5): EXAFS, Mӧssbauer and Magnetic Measurements
Kumar, Durgesh; Banerjee, Alok; Mahmoud, Abdelfattah ULiege et al

in Dalton Transactions (2017), 46

In this report, we have examined the evolution of the structure and rich magnetic transitions such as a paramagnetic to ferrimagnetic phase transition at the Curie temperature (TC), spiral ordering ... [more ▼]

In this report, we have examined the evolution of the structure and rich magnetic transitions such as a paramagnetic to ferrimagnetic phase transition at the Curie temperature (TC), spiral ordering temperature (TS) and lock-in temperature (TL) observed in the CoCr2O4 spinel multiferroic after substituting Fe. The crystal structure, microstructure and cation distribution among the tetrahedral (A) and octahedral (B) sites in the spinel lattice are characterised by X-ray diffraction, transmission electron microscopy, Extended X-ray Absorption Fine Structure (EXAFS) and Mössbauer spectroscopy. Due to the same radial distances of the first coordination shell in both tetrahedral and octahedral environments observed in EXAFS spectra, the position of the second coordination shell specifies the preference of more Fe ions towards the A site at x = 0.1. At x = 0.5, more Fe ions favour the B site. The cation distribution quantitatively obtained from the Mössbauer spectral analysis shows that while 60% of Fe ions occupy the A site in x = 0.1, 40% occupy it in x = 0.5. Surprisingly at x = 0.3, Fe ions are distributed equally among the A and B sites. dc magnetization reveals an increase in TC from 102 K to 200 K and in TS from 26 to 40 K with an increase in Fe concentration, indicating an enhancement in A–B exchange interaction at the expense of B–B. No report has until now demonstrated such an enhancement in TS either in pure or in doped CoCr2O4. Furthermore, frequency-dependent ac susceptibility (χ) data fitted with different phenomenological models such as the Néel–Arrhenius, Vogel–Fulcher and power law confirm a spin-glass and/or cluster-glass behaviour in nanoparticles of CoCr2−xFexO4. [less ▲]

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See detailSynthesis and complexation of superbulky imidazolium-2-dithiocarboxylate ligands
Beltran Alvarez, Tomás Francisco ULiege; Zaragoza, Guillermo; Delaude, Lionel ULiege

in Dalton Transactions (Cambridge, England : 2003) (2017), 46(28), 9036-9048

The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the ... [more ▼]

The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the corresponding imidazolium-2-dithiocarboxylate zwitterions in high yields. These new dithiolate ligands were fully characterized and their coordination chemistry toward common Re(i) and Ru(ii) metal sources was thoroughly investigated. Neutral [ReBr(CO)3(S2C[middle dot]NHC)] chelates featured three facially-arranged carbonyl groups on a distorted octahedron, whereas cationic [RuCl(p-cymene)(S2C[middle dot]NHC)]PF6 complexes displayed a piano-stool geometry. The molecular structures of the six new compounds revealed that the NHC[middle dot]CS2 inner salts were highly flexible. Indeed, the torsion angle between their anionic and cationic moieties varied between ca. 63[degree] in the free ligands and 3[degree] in the ruthenium complexes. Concomitantly, the S-C-S bite angle underwent a contraction from 131[degree] to 110-113[degree] upon chelation. Computation of the %VBur parameter showed that the dithiocarboxylate unit of the NHC[middle dot]CS2 betaines chiefly determined the steric requirements of the imidazolium moieties, irrespective of the metal center involved in the complexation. The replacement of the p-methyl substituents of IDip*Me with p-methoxy groups in IDip*OMe did not significantly affect the ligand bulkiness. The more electron-donating methoxy group led, however, to small changes in various IR wavenumbers used to probe the electron donor properties of the carbene moiety. [less ▲]

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See detailLe maraîchage périurbain à Libreville et Owendo (Gabon) : pratiques culturales et durabilité
Bayendi-Loudit, Sandrine ULiege; Ndoutoume Ndong, Auguste; Francis, Frédéric ULiege

in Cahiers Agricultures (2017)

In Gabon, peri-urban gardening is an opportunity to provide vegetables to the main cities, such as Libreville and Owendo. Following a survey conducted in three market gardening areas, an inventory was ... [more ▼]

In Gabon, peri-urban gardening is an opportunity to provide vegetables to the main cities, such as Libreville and Owendo. Following a survey conducted in three market gardening areas, an inventory was conducted on the socio-economic characteristics, the diversity of crops, and pesticide uses. The cropped areas range from 0.08 ha to 0.4 ha per farmer, according to the site. National operators represent 51%, while people from Burkina Faso manage 40% of vegetable production. The most cultivated species throughout the year are amaranth (Amaranthus hybridus L.), lettuce (Lactuca sativa L.), Guinea sorrel (Hibiscus sabdariffa L.) and black nightshade (Solanum nigrum L.). The most important pests are Aphididae and some beetles. The most commonly used plant protection products are insecticides, mainly conventional neurotoxic. Best crop monitoring, pest control including pesticide application reduction, and the possibility to offer microcredit systems to small producers would help increasing peri-urban healthy vegetable production and increase local food autonomy [less ▲]

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See detailSpray-drying as a tool to disperse conductive carbon inside Na2FePO4F particles by addition of carbon black or carbon nanotubes to the precursor solution
Mahmoud, Abdelfattah ULiege; Caes, Sebastien; Brisbois, Magali et al

in Journal of Solid State Electrochemistry (2017)

In this work, Na2FePO4F-carbon composite powders were prepared by spray-drying a solution of inorganic precursors with 10 and 20 wt% added carbon black (CB) or carbon nanotubes (CNTs). In order to compare ... [more ▼]

In this work, Na2FePO4F-carbon composite powders were prepared by spray-drying a solution of inorganic precursors with 10 and 20 wt% added carbon black (CB) or carbon nanotubes (CNTs). In order to compare the effect of CB and CNTwhen added to the precursor solutions, the structural, electrochemical, and morphological properties of the synthesized Na2FePO4F-xCB and Na2FePO4F-xCNT samples were systematically investigated. In both cases, X-ray diffraction shows that calcination at 600 °C in argon leads to the formation of Na2FePO4F as the major inorganic phase. 57Fe Mössbauer spectroscopy was used as complementary technique to probe the oxidation states, local environment, and identify the composition of the iron-containing phases. The electrochemical performance is markedly better in the case of Na2FePO4F-CNT (20 wt%), with specific capacities of about 100 mAh/g (Na2FePO4F-CNT) at C/4 rate vs. 50 mAh/g for Na2FePO4F-CB (20 wt%). SEM characterization of Na2FePO4F-CB particles revealed different particle morphologies for the Na2FePO4F-CNT and Na2FePO4F-CB powders. The carbon-poor surface observed for Na2FePO4FCB could be due to a slow diffusion of carbon in the droplets during drying. On the contrary, Na2FePO4F-CNT shows a better CNT dispersion inside and at the surface of the NFPF particles that improves the electrochemical performance. [less ▲]

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See detailOccupational social and mental stimulation and cognitive decline with advancing age
Grotz, Catherine ULiege; Meillon, Céline; Amieva, Hélène et al

in Age and Ageing (2017)

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See detailIs supercritical fluid chromatography hyphenated to massspectrometry suitable for the quality control of vitamin D3 oilyformulations?
Andri, Bertyl ULiege; Dispas, Amandine ULiege; Klinkenberg, Régis et al

in Journal of Chromatography. A (2017), 1515

Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a ... [more ▼]

Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a goodalternative over Normal Phase Liquid Chromatography (NPLC). Indeed, modern SFC separations arefast, efficient with suitable quantitative performances. Moreover, the hyphenation of SFC to mass spec-trometry (MS) provides additional gains in specificity and sensitivity. The present work aims at thedetermination of vitamin D3 by SFC-MS for routine Quality Control (QC) of medicines specifically. Basedon the chromatographic parameters previously defined in SFC-UV by Design of Experiments (DoE) andDesign Space methodology, the method was adapted to work under isopycnic conditions ensuring a base-line separation of the compounds. Afterwards, the response provided by the MS detector was optimizedby means of DoE methodology associated to desirability functions. Using these optimal MS parameters,quantitative performances of the SFC-MS method were challenged by means of total error approachmethod validation. The resulting accuracy profile demonstrated the full validity of the SFC-MS method. It was indeed possible to meet the specification established by the European Medicines Agency (EMA) (i.e. 95.0 − 105.0% of the API content) for a dosing range corresponding to at least 70.0-130.0% of theAPI content. These results highlight the possibility to use SFC-MS for the QC of medicine and obviouslysupport the switch to greener analytical methods. [less ▲]

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See detailDeep imaging search for planets forming in the TW Hya protoplanetary disk with the Keck/NIRC2 vortex coronagraph
Ruane, G.; Mawet, D.; Kastner, J. et al

in Astronomical Journal (The) (2017), 154

Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic ... [more ▼]

Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic imaging observations to search for accreting planets especially within dust gaps previously detected in scattered light and submm-wave thermal emission. Three nights of observations with the Keck/NIRC2 vortex coronagraph in $L^\prime$ (3.4-4.1$\mu$m) did not reveal any statistically significant point sources. We thereby set strict upper limits on the masses of non-accreting planets. In the four most prominent disk gaps at 24, 41, 47, and 88 au, we obtain upper mass limits of 1.6-2.3, 1.1-1.6, 1.1-1.5, and 1.0-1.2 Jupiter masses ($M_J$) assuming an age range of 7-10 Myr for TW Hya. These limits correspond to the contrast at 95\% completeness (true positive fraction of 0.95) with a 1\% chance of a false positive within $1^{\prime\prime}$ of the star. We also approximate an upper limit on the product of planet mass and planetary accretion rate of $M_p\dot{M}\lesssim10^{-8} M_J^2/yr$ implying that any putative $\sim0.1 M_J$ planet, which could be responsible for opening the 24 au gap, is presently accreting at rates insufficient to build up a Jupiter mass within TW Hya's pre-main sequence lifetime. [less ▲]

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See detailMapping the dependency of crops on pollinators in Belgium
Jacquemin, Floriane ULiege; Violle, Cyrille; Rasmont, Pierre et al

in One Ecosystem (2017)

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See detailEvaluating model simulations of 20th century sea-level rise. Part 1: Global mean sea-level change
Slangen, A.; Meyssignac, B.; Agosta, Cécile ULiege et al

in Journal of Climate (2017)

Sea-level change is one of the major consequences of climate change and is projected to affect coastal communities around the world. Here, we compare Global Mean Sea-Level (GMSL) change estimated by 12 ... [more ▼]

Sea-level change is one of the major consequences of climate change and is projected to affect coastal communities around the world. Here, we compare Global Mean Sea-Level (GMSL) change estimated by 12 climate models from the 5th phase of the World Climate Research Programme’s Climate Model Intercomparison Project (CMIP5) to observational estimates for the period 1900-2015. We analyse observed and simulated individual contributions to GMSL change (thermal expansion, glacier mass change, ice sheet mass change, landwater storage change) and compare the summed simulated contributions to observed GMSL change over the period 1900-2007 using tide gauge reconstructions, and over the period 1993-2015 using satellite altimetry estimates. The model-simulated contributions allow us to explain 50 ± 30% (uncertainties 1.65σ unless indicated otherwise) of the mean observed change from 1901-1920 to 1988-2007. Based on attributable biases between observations and models, we propose to add a number of corrections, which result in an improved explanation of 75 ± 38% of the observed change. For the satellite era (1993-1997 to 2011-2015) we find an improved budget closure of 102 ± 33% (105 ± 35% when including the proposed bias corrections). Simulated decadal trends over the 20th century increase, both in the thermal expansion and the combined mass contributions (glaciers, ice sheets and landwater storage). The mass components explain the majority of sea-level rise over the 20th century, but the thermal expansion has increasingly contributed to sea-level rise, starting from 1910 onwards and in 2015 accounting for 46% of the total simulated sea-level change. [less ▲]

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See detailShape and spin determination of Barbarian asteroids
Devogele, Maxime ULiege; Tanga, P.; Bendjoya, P. et al

in Astronomy and Astrophysics (2017)

The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such ... [more ▼]

The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such properties were identified. As has been suggested, large scale topographic features could play a role in the polarimetric response, if the shapes of Barbarians are particularly irregular and present a variety of scattering/incidence angles. This idea is supported by the shape of (234) Barbara, that appears to be deeply excavated by wide concave areas revealed by photometry and stellar occultations. Aims. With these motivations, we started an observation campaign to characterise the shape and rotation properties of Small Main- Belt Asteroid Spectroscopic Survey (SMASS) type L and Ld asteroids. As many of them show long rotation periods, we activated a worldwide network of observers to obtain a dense temporal coverage. Methods. We used light-curve inversion technique in order to determine the sidereal rotation periods of 15 asteroids and the con- vergence to a stable shape and pole coordinates for 8 of them. By using available data from occultations, we are able to scale some shapes to an absolute size. We also study the rotation periods of our sample looking for confirmation of the suspected abundance of asteroids with long rotation periods. Results. Our results show that the shape models of our sample do not seem to have peculiar properties with respect to asteroids with similar size, while an excess of slow rotators is most probably confirmed. [less ▲]

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See detailSelf-assembly processes of superparamagnetic colloids in a quasi-two-dimensional system
Rojas, Nicolas; Darras, Alexis ULiege; Lumay, Geoffroy ULiege

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2017), 96(1), 012608

Superparamagnetic colloids gather depending on the magnitude of the magnetic field applied, forming chains and ribbons in a quasi-two-dimensional chamber. The results presented in this work are in good ... [more ▼]

Superparamagnetic colloids gather depending on the magnitude of the magnetic field applied, forming chains and ribbons in a quasi-two-dimensional chamber. The results presented in this work are in good agreement with recent experimental multistable data for the mean length of the aggregates in thermodynamic equilibrium. [less ▲]

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See detailDo Management and Executive Share the same Perception on the critical Issues Facing the Frontline Nursing Staff ?
Nyssen, Anne-Sophie ULiege; GILLET, Aline ULiege; Sougné, Jacques ULiege et al

in International Journal of Healthcare Management (2017)

Changes in managerial practices increasingly distance managers from staff by promoting rotation. It could be thought that this distance changes the perception managers have of work constraints and ... [more ▼]

Changes in managerial practices increasingly distance managers from staff by promoting rotation. It could be thought that this distance changes the perception managers have of work constraints and resources. This study attempts to tackle staff and leadership disparate views on the issues facing front-line nursing staff. We sent an online questionnaire on work constraints and good practices to nursing chiefs from Belgium hospitals and conducted focus groups with their ‘front-line’ nursing staff in order to compare perceptions. 40% of the chief nurses mentioned as a regular problems for their staff: production pressure, working time, doctors–nurses collaboration and managing new staff. Except for the ‘productive pressure’, these issues are rather considered by the staff as occasional problems. Front-line staffs evaluate infrastructure, heat, working positions as more common problems. However, statistical analyses showed one significant difference in perception: management of incidents/accidents. Health care organizations should promote participatory management tools both to diagnose work constraints and to elaborate action priorities in order to guarantee a shared understanding of decisions making between staff and supervisors. [less ▲]

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See detailTypical versus delayed speech onset influences verbal reporting of autistic interests
Chiodo, Liliane ULiege; Majerus, Steve ULiege; Mottron, Laurent

in Molecular Autism (2017)

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is ... [more ▼]

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is associated with clinical, cognitive, and neural differences. It is unknown whether these different speech development pathways and associated cognitive differences are involved in the heterogeneity of the restricted interests that characterize autistic adults. [less ▲]

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See detailAcromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) database.
PETROSSIANS, Patrick ULiege; Daly, Adrian ULiege; Natchev, Emil et al

in Endocrine-Related Cancer (2017)

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly ... [more ▼]

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liege Acromegaly Survey (LAS) database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs. 46.4 years; p<0.001). The median delay from first symptoms to diagnosis was two years longer in females (p=0.015). Ages at diagnosis and first symptoms increased significantly over time (p<0.001). Tumors were larger in males than females (p<0.001); tumor size and invasion were inversely related to patient age (p<0.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (p<0.001). GH was inversely related to age in both sexes (p<0.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in <5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6-4.4% had experienced a fracture. This study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis. [less ▲]

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See detailNatural patches in Posidonia oceanica meadows: the seasonal biogeochemical pore water characteristics of two edge types
Abadie, A; Borges, Alberto ULiege; Champenois, Willy ULiege et al

in Marine Biology (2017), 164:166

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural ... [more ▼]

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural particularity which consist in a duality of their edge types. One edge is eroded by bottom currents, while the adjacent meadow colonizes the bare sediments. This study aims to study the dynamics of these two edges through the investigation of the biogeochemistry (pH, total alkalinity, dissolved inorganic carbon, CO2, CH4, N2O, H2S, dissolved inorganic nitrogen, PO4 3−) within vegetated and unvegetated sediments. These observations are compared with the adjacent meadow to have a better understanding of the colonization processes. Our results reveal that the P. oceanica matrix shows differences from the vegetated edges of sand patches, especially with regard to nutrient availability, which is generally more important at the colonized edge (dissolved inorganic nitrogen up to 65.39 μM in June). A clear disparity also occurs between the eroded and colonized edge with both a seasonal and bathymetrical variation of leaf biomass with higher disparities at 10 m in June (colonized edge 1415 gDW m−2; eroded edge 1133 gDW m−2). Themost important contrasts during this study were assessed in June, suggesting that the warm period of the year is more suitable for sampling to highlight disparate characteristics in temperate seagrass meadows. These findings put into light the potential importance of biogeochemical processes in the dynamics of natural patch edges. We hypothesize that they may influence the structural dynamics of P. oceanica seascapes. [less ▲]

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See detailA palaeoecological model for the late Mesoproterozoic–early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern Africa
Beghin, Jérémie ULiege; Guilbaud, Romain; Poulton, Simon W. et al

in Precambrian Research (2017), 299

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions ... [more ▼]

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions. Here, we combine the geological context and a reconstruction of palaeoenvironmental redox conditions (using iron speciation) with quantitative analysis of microfossil assemblages (eukaryotes andincertae sedis), to provide the first palaeoecological model for the Atar/El Mreïti Group of the Taoudeni Basin. Our model suggests that in the late Mesoproterozoic–early Neoproterozoic, the availability of both molecular oxygen and nutrients controlled eukaryotic diversity, higher in oxic shallow marginal marine environments, while coccoidal colonies and benthic microbial mats dominated respectively in anoxic iron-rich and euxinic waters during marine highstands or away from shore where eukaryotes are lower or absent. [less ▲]

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See detailFardeau des maladies chroniques en Afrique subsaharienne : plaidoyer pour une mise en place des soins palliatifs et d’accompagnement en fin de vie en République démocratique du Congo
Lofandjola Masumbuku, Jacques ULiege

in Ethics, Medicine and Public Health (2017)

Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They ... [more ▼]

Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They require care for more than 6 months (cardiovascular, oncological diseases, chronic respiratory diseases, diabetes and HIV / AIDS), are responsible for 63% death. Relatively little reliable information about these diseases is available. Lists containing the major chronic diseases exist but they are scalable and do not always agree [less ▲]

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See detailNegative velocity fluctuations and non-equilibrium fluctuation relation for a driven high critical current vortex state
Bag, Biplab; Shaw, Gorky ULiege; Banerjee, S. S. et al

in Scientific Reports (2017), 7(1), 5531

Under the influence of a constant drive the moving vortex state in 2H-NbS2 superconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an immobile state. This state ... [more ▼]

Under the influence of a constant drive the moving vortex state in 2H-NbS2 superconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an immobile state. This state possesses a high depinning current threshold ( $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h ) with unconventional depinning characteristics. At currents well above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , the moving vortex state exhibits a multimodal velocity distribution which is characteristic of vortex flow instabilities in the NDR regime. However at lower currents which are just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , the velocity distribution is non-Gaussian with a tail extending to significant negative velocity values. These unusual negative velocity events correspond to vortices drifting opposite to the driving force direction. We show that this distribution obeys the Gallavotti-Cohen Non-Equilibrium Fluctuation Relation (GC-NEFR). Just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , we also find a high vortex density fluctuating driven state not obeying the conventional GC-NEFR. The GC-NEFR analysis provides a measure of an effective energy scale (E eff ) associated with the driven vortex state. The E eff corresponds to the average energy dissipated by the fluctuating vortex state above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h . We propose the high E eff value corresponds to the onset of high energy dynamic instabilities in this driven vortex state just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h . [less ▲]

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See detailGlobal regression model for moisture content determination using near-infrared spectroscopy
Clavaud, Matthieu ULiege; Roggo, Yves; Degardin, Klara et al

in European Journal of Pharmaceutics and Biopharmaceutics (2017), 119

Near-infrared (NIR) global quantitative models were evaluated for the moisture content (MC) determination of three different freeze-dried drug products. The quantitative models were based on 3822 spectra ... [more ▼]

Near-infrared (NIR) global quantitative models were evaluated for the moisture content (MC) determination of three different freeze-dried drug products. The quantitative models were based on 3822 spectra measured on two identical spectrometers to include variability. The MC, measured with the reference Karl Fischer (KF) method, were ranged from 0.05% to 4.96%. Linear and non-linear regression models using Partial Least Square (PLS), Decision Tree (DT), Bayesian Ridge Regression (Bayes-RR), K-Nearest Neighbors (KNN), and Support Vector Regression (SVR) algorithms were created and evaluated. Among them, the SVR model was retained for a global application. The Standard Error of Calibration (SEC) and the Standard Error of Prediction (SEP) were respectively 0.12% and 0.15%. This model was then evaluated in terms of total error and risk-based assessment, linearity, and accuracy. It was observed that MC can be fastly and simultaneously determined in freeze-dried pharmaceutical products thanks to a global NIR model created with different medicines. This innovative approach allows to speed up the validation time and the in-lab release analyses. [less ▲]

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See detailAn active bacterial community linked to high chl-a concentrations in Antarctic winter-pack ice and evidence for the development of an anaerobic sea-ice bacterial community
Eronen-Rasimus, Eeva; Luhtanen, Anne-Mari; Rintala, Janne-Markus et al

in ISME Journal (The) (2017), 1-11

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to ... [more ▼]

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to high (o4 μg l–1) chlorophyll-a (chl-a) concentrations and consequent bacterial production. Typical sea-ice bacterial genera, for example, Octadecabacter, Polaribacter and Glaciecola, often abundant in spring and summer during the sea-ice algal bloom, predominated in the communities. The variability in bacterial community composition in the different ice types was mainly explained by the chl-a concentrations, suggesting that as in spring and summer sea ice, the sea-ice bacteria and algae may also be coupled during the Antarctic winter. Coupling between the bacterial community and sea-ice algae was further supported by significant correlations between bacterial abundance and production with chl-a. In addition, sulphate-reducing bacteria (for example, Desulforhopalus) together with odour of H2S were observed in thick, apparently anoxic ice, suggesting that the development of the anaerobic bacterial community may occur in sea ice under suitable conditions. In all, the results show that bacterial community in Antarctic sea ice can stay active throughout the winter period and thus possible future warming of sea ice and consequent increase in bacterial production may lead to changes in bacteria-mediated processes in the Antarctic sea-ice zone. [less ▲]

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See detailCosmological Time, Entropy and Infinity
Hauret, Clémentine ULiege; Magain, Pierre ULiege; Biernaux, Judith ULiege

in Entropy (2017), 19(7),

Time is a parameter playing a central role in our most fundamental modelling of natural laws. Relativity theory shows that the comparison of times measured by different clocks depends on their relative ... [more ▼]

Time is a parameter playing a central role in our most fundamental modelling of natural laws. Relativity theory shows that the comparison of times measured by different clocks depends on their relative motion and on the strength of the gravitational field in which they are embedded. In standard cosmology, the time parameter is the one measured by fundamental clocks (i.e., clocks at rest with respect to the expanding space). This proper time is assumed to flow at a constant rate throughout the whole history of the universe. We make the alternative hypothesis that the rate at which the cosmological time flows depends on the dynamical state of the universe. In thermodynamics, the arrow of time is strongly related to the second law, which states that the entropy of an isolated system will always increase with time or, at best, stay constant. Hence, we assume that the time measured by fundamental clocks is proportional to the entropy of the region of the universe that is causally connected to them. Under that simple assumption, we find it possible to build toy cosmological models that present an acceleration of their expansion without any need for dark energy while being spatially closed and finite, avoiding the need to deal with infinite values. [less ▲]

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See detailAir-water interfacial properties of enzymatically hydrolyzed wheat gluten in the presence of sucrose
Wouters, Arno G.B.; Fierens, Ellen; Rombouts, Ine et al

in Food Hydrocolloids (2017), (73), 284-294

Enzymatically hydrolyzed wheat gluten proteins may be a valuable alternative to animal proteins as foaming agents in food. Studies of the air-water (A-W) interfacial properties of such hydrolysates in ... [more ▼]

Enzymatically hydrolyzed wheat gluten proteins may be a valuable alternative to animal proteins as foaming agents in food. Studies of the air-water (A-W) interfacial properties of such hydrolysates in aqueous solutions contribute to the understanding of their functionality in food systems. We here studied the A-W interfacial characteristics of wheat gluten hydrolysates (GHs) in the absence and presence of sucrose. Sucrose increased (P < 0.05) the foaming capacity, which is the initial amount of foam formed, of GHs. This is probably related to an increased affinity of GHs for the A-W interface in the presence of sucrose, as could be observed by higher (P < 0.05) rates of diffusion to and adsorption at the A-W interface of the GH constituents in sucrose solution compared to those in water. Furthermore, the surface dilatational moduli of GH protein films at A-Winterfaces were in most cases higher (P < 0.05) in a sucrose solution than in water. The latter could only partly be related to differences in foam stability. Surface hydrophobicity and intrinsic tryptophan fluorescence measurements revealed that protein conformational changes in the presence of sucrose might be at the basis of the observed differences. Another possibility is that the hydrophilic sucrose molecules in the bulk cause the more hydrophobic protein molecules to concentrate at the interface, more so than in water. In conclusion, it is crucial to investigate the foaming of plant protein hydrolysates in media more complex than water, as other nonsurface-active food ingredients alter their interfacial behavior. [less ▲]

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See detailEffects of an experimental resource pulse on the macrofaunal assemblage inhabiting seagrass macrophytodetritus
Remy, François ULiege; Gobert, Sylvie ULiege; Lepoint, Gilles ULiege

in Belgian Journal of Zoology (2017), 147(1), 1-15

Physical disturbances and resource pulses are major structuring drivers of terrestrial and aquatic ecosystems. The accumulations of exported dead leaves from the Neptune grass, Posidonia oceanica (L ... [more ▼]

Physical disturbances and resource pulses are major structuring drivers of terrestrial and aquatic ecosystems. The accumulations of exported dead leaves from the Neptune grass, Posidonia oceanica (L.) Delile are ephemeral and highly dynamic detrital habitats offering food sources and shelter for vagile macrofauna community. These habitats are frequently subject to wind and storms which can add “new” detrital material to previous accumulations; these can be defined as resource pulses and could potentially impact the associated macrofauna. This study assesses the impact of an experimental resource pulse on the macrofauna associated with exported P. oceanica litter accumulations. The experimental design consisted of two pulse treatments (the addition of dead leaves with and without the associated fauna), and two controls (one procedural, and one total control), where the added material was left underwater for 14 days. Invertebrates then present in the sampled detritus were all identified and counted. Our data suggest that the responses of these invertebrates to resource pulses present intermediate characteristics between aquatic and terrestrial ecosystems responses. Inputting a moderate amount of dead P. oceanica leaves into experimental mesocosms had a non-negligible impact and rapidly affected the macrofauna community. Specialist detritivores species were boosted while herbivore/detritivore species dramatically decreased. Predators also showed a modest but significant density increase, demonstrating the fast propagation of the pulse response throughout the entire community and through several trophic levels. Strict hypoxia-tolerant species were also only observed in the treated mesocosms, indicating the strong influence of resource pulses on physico-chemical conditions occurring inside litter accumulations. [less ▲]

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See detailInhibiteurs de la pompe à protons et risque d'insuffisance rénale
PAQUOT, Francois ULiege; Krzesinski, Jean-Marie ULiege

in Revue Médicale Suisse (2017)

Regarded as safe and effective for management of upper peptic ulcer disease due to gastric acid secretion, the proton pump inhibitors are among the most commonly prescribed drugs. Their use, however, is ... [more ▼]

Regarded as safe and effective for management of upper peptic ulcer disease due to gastric acid secretion, the proton pump inhibitors are among the most commonly prescribed drugs. Their use, however, is not without concerns. Acute kidney injury, mainly due to acute interstitial nephritis, could happen 1.5 to 2 times more frequently when using these drugs. Moreover, a risk for chronic kidney disease has also be noted with proton pump inhibitor use (1.15 to 1.8 increased risk), although biases may exist due to confounding factors related to the observational nature of the studies. So, caution is required before available results from good prospective randomized studies are available. Renal function should be checked when using these medications and timely cessation should be advised when there is no more clear indication for use. [less ▲]

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See detailStability of pentaquarks with a two- plus three-body chromoelectric interaction
Stancu, Floarea ULiege

in Physical Review. D : Particles and Fields (2017), 96

We study the stability of pentaquarks within a schematic model based on SU(3) color symmetry, by taking into account algebraic arguments leading to a chromoelectric interaction containing two- and three ... [more ▼]

We study the stability of pentaquarks within a schematic model based on SU(3) color symmetry, by taking into account algebraic arguments leading to a chromoelectric interaction containing two- and three-body parts. It has already been proven that such an interaction can influence the spectrum of ordinary baryons and the stability of tetraquarks and hexaquarks. Here we discuss its role in the stability of pentaquarks against strong decays. [less ▲]

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See detailDoes Belgian Holocene speleothem record solar forcing and cold events?
Allan, Mohammed ULiege; Deliège, Adrien ULiege; Nicolay, Samuel ULiege et al

in Climate of the Past Discussions (2017)

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12 ... [more ▼]

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12.7 ka according to U/Th dating. High spatial resolution measurements of trace elements (Sr, Ba, Mg and Al) were done by Laser-Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Trace elements profiles were interpreted as environmental and climate changes in the Han-sur-Lesse region. Power spectrum estimators and continuous wavelet transform were applied on trace elements time series to detect any statistically significant periodicities in the PN stalagmite. Spectral analyses reveal decadal to millennial periodicities (i.e., 68–75, 133–136, 198–209, 291–358, 404–602, 912–1029 and 2365–2670 yr) in the speleothem record. Results were compared to reconstructed sunspot number data to determine whether solar signal is presents in PN speleothem. The occurrence of significant solar periodicities (i.e., cycles of Gleissberg, de Vries, unnamed 500 years, Eddy and Hallstat) supports for an impact of solar forcing on PN speleothem trace elements contents. Moreover, several intervals of significant rapid climate change were detected during the Holocene at 10.3, 9.3–9.5, around 8.2, 6.4–6.2, 4.7–4.5, and around 2.7 ka BP. Those intervals are similar to the cold events evidenced in different natural paleoclimate archivers, suggesting common climate forcing mechanisms related to changes in solar irradiance. [less ▲]

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See detailMesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1
Rowart, Pascal ULiege; ERPICUM, Pauline ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Stem Cells International (2017)

Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we ... [more ▼]

Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we hypothesized that MSC modulate TJ formation, via the AMP-activated kinase (AMPK) pathway. Liver kinase-β1 (LKB1) and Ca2+-calmodulin-dependent protein kinase kinase (CaMKK) represent the main kinases that activate AMPK. Methods. The in vitro Ca2+ switch from 5 μM to 1.8 mM was performed using epithelial Madin-Darby canine kidney (MDCK) cells cultured alone or cocultured with rat bone marrow-derived MSC or preexposed to MSC-conditioned medium. TJ assembly was measured by assessing ZO-1 relocation to cell-cell contacts. Experiments were conducted using MDCK stably expressing short-hairpin-RNA (shRNA) against LKB1 or luciferase (LUC, as controls). Compound STO-609 (50 μM) was used as CaMKK inhibitor. Results. Following Ca2+ switch, ZO-1 relocation and phosphorylation/activation of AMPK were significantly higher in MDCK/MSC compared to MDCK. No difference in AMPK phosphorylation was observed between LKB1-shRNA and Luc-shRNA MDCK following Ca2+ switch. Conversely, incubation with STO-609 prior to Ca2+ switch prevented AMPK phosphorylation and ZO-1 relocation. MSC-conditioned medium slightly but significantly increased AMPK activation and accelerated TJ-associated distribution of ZO-1 post Ca2+ switch in comparison to regular medium. Conclusions. MSC modulate the assembly of epithelial TJ, via the CaMKK/AMPK pathway independently of LKB1. [less ▲]

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See detailDoes Belgian Holocene speleothem record solar forcing and cold events?
Allan, Mohammed ULiege; Deliège, Adrien ULiege; Nicolay, Samuel ULiege et al

in Climate of the Past Discussions (2017)

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12 ... [more ▼]

We present a decadal-centennial scale Holocene climate record based on trace elements contents from a 65 cm stalagmite (Père Noël) from Belgian Père Noël cave. Père Noël (PN) stalagmite covers the last 12.7 ka according to U/Th dating. High spatial resolution measurements of trace elements (Sr, Ba, Mg and Al) were done by Laser-Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Trace elements profiles were interpreted as environmental and climate changes in the Han-sur-Lesse region. Power spectrum estimators and continuous wavelet transform were applied on trace elements time series to detect any statistically significant periodicities in the PN stalagmite. Spectral analyses reveal decadal to millennial periodicities (i.e., 68–75, 133–136, 198–209, 291–358, 404–602, 912–1029 and 2365–2670 yr) in the speleothem record. Results were compared to reconstructed sunspot number data to determine whether solar signal is presents in PN speleothem. The occurrence of significant solar periodicities (i.e., cycles of Gleissberg, de Vries, unnamed 500 years, Eddy and Hallstat) supports for an impact of solar forcing on PN speleothem trace elements contents. Moreover, several intervals of significant rapid climate change were detected during the Holocene at 10.3, 9.3–9.5, around 8.2, 6.4–6.2, 4.7–4.5, and around 2.7 ka BP. Those intervals are similar to the cold events evidenced in different natural paleoclimate archivers, suggesting common climate forcing mechanisms related to changes in solar irradiance. [less ▲]

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See detailIn vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (Asteraceae)
Bordignon, Annélise ULiege; Frederich, Michel ULiege; Ledoux, Allison ULiege et al

in Natural Product Research (2017)

According to the World Health Organization (WHO 2016 WHO. 2016. World Malaria report 2016 [Internet]; [cited 2016 Dec 20]. Available from: https://www.who.int/malaria/publications/world-malaria-report ... [more ▼]

According to the World Health Organization (WHO 2016 WHO. 2016. World Malaria report 2016 [Internet]; [cited 2016 Dec 20]. Available from: https://www.who.int/malaria/publications/world-malaria-report-2016/report/en/ [Google Scholar] ), malaria caused at least 429 000 deaths globally in 2015. Among these, 70% were children under the age of five and 99% were due to the parasite species Plasmodium falciparum. The fight against this major public health problem is threatened by the rapid emergence and spread of parasite strains resistant towards available approved treatments. Urgent efforts are therefore needed to identify new antimalarial drugs. As such, our research groups decided to study Reunion Island as a potential source for the discovery of new antiplasmodial metabolites. This natural patrimony has been identified as a biodiversity hotspot due to its numerous endemic species and its preserved ecosystems (Myers et al. 2000 Myers N, Mittermeier RA, Mittermeier CG, DaFonesca GAB, Kent J. 2000. Biodiversity hotspots for conservation priorities. Nature. 403:853–858.10.1038/35002501 [CrossRef], [PubMed], [Web of Science ®], [Google Scholar] ). The National Botanical Conservatory of the Mascarenes indicates that Vernonia fimbrillifera Less. is an endemic species from Reunion Island, locally named ‘bois de source’, which grows in the humid tropical forest (Lavergne and Véra 1989 Lavergne R, Véra R. 1989. Etude ethnobotanique des plantes utilisées dans la pharmacopée traditionnelle à La Réunion [Ethnobotanical study of plants used in the traditional pharmacopoeia of Reunion Island]. Paris: Agence de coopération culturelle et technique. [Google Scholar] ). To the best of our knowledge, neither phytochemical nor pharmacological works have been performed up to now on V. fimbrillifera. This study isolated and determined the structure of three antiplasmodial sesquiterpene lactones. Compounds were additionally tested in vitro for their cytotoxicity and their selectivity indices were established. [less ▲]

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See detailRecurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy
DARCIS, Gilles ULiege; Van der Auwera, Gert; GIOT, Jean-Baptiste ULiege et al

in BMC Infectious Diseases (2017), 17

Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many ... [more ▼]

Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many other infectious or alignant diseases. The disease can present in three ways: cutaneous, mucocutaneous, or visceral leishmaniasis, which rarely occur together or consecutively. Case presentation: The patient was a 52 years old immunosuppressed Belgian woman with a long history of severe rheumatoid arthritis. She underwent bone marrow biopsy to explore thrombocytopenia. Diagnosis of visceral leishmaniasis was made by identification of Leishman Donovan (LD) bodies in macrophages. Treatment with liposomal amphotericin B was successful. She later developed cutaneous leishmaniasis treated with amphotericin B lipid complex. She next presented with relapsing cutaneous lesions followed by rapidly progressing lymphadenopathies. Biopsy confirmed the diagnosis of leishmaniasis. Treatments by miltefosine, amphotericin B, N-methyl-glucamine antimoniate were subsequently initiated. She later presented a recurrent bone marrow involvement treated with intramuscular paromomycin and miltefosine. She died two years later from leukemia. At the time of death, she presented with a mucosal destruction of the nose. A Leishmania-specific PCR (Polymerase Chain Reaction) identified L. infantum as etiological agent. Conclusions: Clinicians should be aware of the potential concomitant or sequential involvement of multiple anatomic localizations of Leishmania in immunosuppressed patients. [less ▲]

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See detailImplicit Belittlements Call for Implicit Measures: Emotional Reactions to Youth Paternalistic Stereotypes
Silvestre, Aude ULiege; Huart, Johanne ULiege; Dardenne, Benoît ULiege

in Psychologica Belgica (2017), 57(2), 133-153

Age discrimination at work can potentially affect every worker. Indeed, like ‘old’ workers, young ones hired in their first job elicit the idea that they have quite interesting social abilities but lack ... [more ▼]

Age discrimination at work can potentially affect every worker. Indeed, like ‘old’ workers, young ones hired in their first job elicit the idea that they have quite interesting social abilities but lack of competence, which constitutes a case of paternalistic stereotypes (Fiske, Cuddy, Glick, & Xu, 2002). Generally, the negative (incompetence) facet of such stereotypes is not blatantly expressed, but is subtly conveyed behind an apparently positive discourse. Consequently, it is considered as being generally under-detected, while harmful. In this paper, we examine whether paternalistic stereotyping’s under-detection is real or if it is due to the use of inadequate measures. Based on a study showing that targets feel that something is wrong (Dardenne, Dumont, & Bollier 2007), we rely on affective measures to investigate whether the detection of the subtly conveyed negative facet of paternalistic stereotypes calls for subtle, implicit measures. In Study 1, explicit self-reports of targets’ affective states after a meeting with a paternalistic boss revealed mainly positive affect. In Study 2, an implicit emotional measure however revealed the presence of a negative affective state. The last Study, using a more ecological affective measure, demonstrates that paternalistic stereotypes trigger an ambivalent affective reaction. Altogether, the three studies suggest that the negative facet of paternalistic stereotypes is not as under-detected as we thought. [less ▲]

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See detailPropagation of material and surface profile uncertainties on MEMS micro-resonators using a stochastic second-order computational multi-scale approach
Lucas, Vincent ULiege; Golinval, Jean-Claude ULiege; Voicu, Rodica et al

in International Journal for Numerical Methods in Engineering (2017), 111(1), 26-68

This paper aims at accounting for the uncertainties due to material structure and surface topology of microbeams in a stochastic multiscale model. For micro-resonators made of anisotropic polycrystalline ... [more ▼]

This paper aims at accounting for the uncertainties due to material structure and surface topology of microbeams in a stochastic multiscale model. For micro-resonators made of anisotropic polycrystalline materials, micro-scale uncertainties are due to the grain size, grain orientation, and to the surface profile. First, microscale realizations of stochastic volume elements (SVEs) are obtained based on experimental measurements. To account for the surface roughness, the SVEs are defined as a volume element having the same thickness as the MEMS, with a view to the use of a plate model at the structural scale. The uncertainties are then propagated up to an intermediate scale, the meso-scale, through a second-order homogenization procedure.From the meso-scale plate resultant material property realizations, a spatially correlated random field of the in plane, out of plane, and cross resultant material tensors can be characterized. Owing to this characterized random field, realizations of MEMS-scale problems can be defined on a plate finite element model. Samples of the macro-scale quantity of interest can then be computed by relying on a Monte-Carlo simulation procedure. As a case study, the resonance frequency of MEMS micro-beams is investigated for different uncertainty cases, such as grain preferred orientations and surface roughness effects. [less ▲]

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See detailConditions for thermally induced all-optical switching in ferrimagnetic alloys: Modeling of TbCo
Moreno, Roberto; Ostler, Thomas ULiege; Chantrell, Roy et al

in Physical Review B (2017), 96

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See detailInfluence of environmental factors on food intake among nursing home residents: a survey combined with a video approach
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; Morelle, Alison et al

in Clinical Interventions in Aging (2017), 12

Background: In addition to the well-known physiological factors, dietary behavior that affects health seems to be influenced by a wide variety of environmental factors. The aim of this study was to assess ... [more ▼]

Background: In addition to the well-known physiological factors, dietary behavior that affects health seems to be influenced by a wide variety of environmental factors. The aim of this study was to assess, by means of an original video approach, the influence of the environment on food intake in nursing homes. Methods: The perception of the environment during meals in nursing homes was evaluated by residents and by two groups of volunteers who either work in the field of geriatrics, or who do not work in the field of geriatrics. First, a random sample of residents answered a self-administered questionnaire related to different indicators (ie, noise, space, comfort, light, odors, perceived satisfaction of meals, taste of meals, presentation of meals, service and setting). Second, two separate panels, one including the people who work in the field of geriatrics (ie, experts) and one including the people who have no particular interest in geriatrics (ie, nonexperts), were asked to answer a questionnaire on their perception of the environment after having watched a video of the lunch in each nursing home. Then, the food intake of the residents was measured by a precise food-weighing method. Results: A total of 88 residents from nine different nursing homes, 18 experts and 45 nonexperts answered the questionnaires. This study highlighted that, on the one hand, after adjustment on confounding variables, the perception of the quantity of food served by the residents is the only single factor associated with food consumption (P=0.003). On the other hand, experts and nonexperts did not perceive any environmental factor that seems to be significantly associated with residents’ food intake. Conclusion: Our results highlighted that, in a nursing home setting, environmental factors have limited influence on the food intake of the residents, with the exception of their own perception of the quantity served. The relevance of this factor deserves further investigation. [less ▲]

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See detailEffect of Organic Solvents on Microalgae Growth, Metabolism and Industrial Bioproduct Extraction: A Review
Miazek, Krystian ULiege; Kratky, Lukas; Sulc, Radek et al

in International Journal of Molecular Sciences (2017)

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See detailGround-based monitoring of comet 67P/Churyumov–Gerasimenko gas activity throughout the Rosetta mission
Opitom, C.; Snodgrass, C.; Fitzsimmons, A. et al

in Monthly Notices of the Royal Astronomical Society (2017), 469

Simultaneously to the ESA Rosetta mission, a world-wide ground-based campaign provided measurements of the large scale activity of comet 67P/Churyumov-Gerasimenko through measurement of optically active ... [more ▼]

Simultaneously to the ESA Rosetta mission, a world-wide ground-based campaign provided measurements of the large scale activity of comet 67P/Churyumov-Gerasimenko through measurement of optically active gas species and imaging of the overall dust coma. We present more than 2 yr of observations performed with the FORS2 low-resolution spectrograph at the VLT, TRAPPIST and ACAM at the WHT. We focus on the evolution of the CN production as a tracer of the comet activity. We find that it is asymmetric with respect to perihelion and different from that of the dust. The CN emission is detected for the first time at 1.34 au pre-perihelion and production rates then increase steeply to peak about 2 weeks after perihelion at (1.00 ± 0.10) × 10[SUP]25[/SUP] molecules s[SUP]-1[/SUP], while the post-perihelion decrease is more shallow. The evolution of the comet activity is strongly influenced by seasonal effects with enhanced CN production when the Southern hemisphere is illuminated. [less ▲]

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See detailModeling dermatophytosis in reconstructed human epidermis: A new tool to study infection mechanisms and to test antifungal agents
Faway, Emilie; Cambier, Ludivine; Mignon, Bernard ULiege et al

in Medical Mycology (2017), 55(5), 485-494

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See detailMUSE-inspired view of the quasar Q2059-360, its Lyman α blob, and its neighborhood
North, P. L.; Marino, R. A.; Gorgoni, C. et al

in Astronomy and Astrophysics (2017), 604

The radio-quiet quasar Q2059-360 at redshift z = 3.08 is known to be close to a small Lyman α blob (LAB) and to be absorbed by a proximate damped Lyα (PDLA) system. Here, we present the Multi Unit ... [more ▼]

The radio-quiet quasar Q2059-360 at redshift z = 3.08 is known to be close to a small Lyman α blob (LAB) and to be absorbed by a proximate damped Lyα (PDLA) system. Here, we present the Multi Unit Spectroscopic Explorer (MUSE) integral field spectroscopy follow-up of this quasi-stellar object (QSO). Our primary goal is to characterize this LAB in detail by mapping it both spatially and spectrally using the Lyα line, and by looking for high-ionization lines to constrain the emission mechanism. Combining the high sensitivity of the MUSE integral field spectrograph mounted on the Yepun telescope at ESO-VLT with the natural coronagraph provided by the PDLA, we map the LAB down to the QSO position, after robust subtraction of QSO light in the spectral domain. In addition to confirming earlier results for the small bright component of the LAB, we unveil a faint filamentary emission protruding to the south over about 80 pkpc (physical kpc); this results in a total size of about 120 pkpc. We derive the velocity field of the LAB (assuming no transfer effects) and map the Lyα line width. Upper limits are set to the flux of the N v λ1238 - 1242, C iv λ1548 - 1551, He ii λ1640, and C iii] λ1548 - 1551 lines. We have discovered two probable Lyα emitters at the same redshift as the LAB and at projected distances of 265 kpc and 207 kpc from the QSO; their Lyα luminosities might well be enhanced by the QSO radiation. We also find an emission line galaxy at z = 0.33 near the line of sight to the QSO. This LAB shares the same general characteristics as the 17 others surrounding radio-quiet QSOs presented previously. However, there are indications that it may be centered on the PDLA galaxy rather than on the QSO. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 60.A-9331(A). [less ▲]

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See detailBaudelaire: traductor auctoritas
Mogollon Zapata, Juan Manuel ULiege

in Literatura: Historia, Teoría, Crítica (2017), 19(2), 19-51

In order to achieve visibility in the media and a position recognized by both the public and their peers, translators are compelled to take advantage of spaces of enunciation such as those provided by ... [more ▼]

In order to achieve visibility in the media and a position recognized by both the public and their peers, translators are compelled to take advantage of spaces of enunciation such as those provided by prefaces, criticism, or biographical notes. Thanks to these spaces, in which translators deploy discursive and institutional strategies that allow them to position themselves and their translation project, translators acquire the status of translator-auctoritas, that is, a level of symbolic authority capable of endowing them with a public image. Through the detailed analysis of the editorial strategies and institutional calculations implemented by Baudelaire in order to position his project of translating Edgar Allan Poe, we show how the poet achieves the status of translator-autoritas and the role the latter played in the construction of his own literary identity [less ▲]

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See detailThe role of mucus in cell-based models used to screen mucosal drug delivery
Lechanteur, Anna ULiege; das Neves, José; Sarmento, Bruno

in Advanced Drug Delivery Reviews (2017)

The increasing interest in developing tools to predict drug absorption through mucosal surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro techniques for drug ... [more ▼]

The increasing interest in developing tools to predict drug absorption through mucosal surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro techniques for drug permeability assessment are less laborious, cheaper and address the concerns of using laboratory animals. Simultaneously, in vitro barrier models that thoroughly simulate human epithelia or mucosae may provide useful data to speed up the entrance of new drugs and new drug products into the clinics. Nevertheless, standard cell-based in vitro models that intend to reproduce epithelial surfaces often discard the role of mucus in influencing drug permeation/absorption. Biomimetic models of mucosae in which mucus production has been considered may not be able to fully reproduce the amount and architecture of mucus, resulting in biased characterization of permeability/absorption. In these cases, artificial mucus may be used to supplement cell-based models but still proper identification and quantification are required. In this review, considerations regarding the relevance of mucus in the development of cell-based epithelial and mucosal models mimicking the gastro-intestinal tract, the cervico-vaginal tract and the respiratory tract, and the impact of mucus on the permeability mechanisms are addressed. From simple epithelial monolayers to more complexes 3D structures, the impact of the presence of mucus for the extrapolation to the in vivo scenario is critically analyzed. Finally, an overview is provided on several techniques and methods to characterize the mucus layer over cell-based barriers, in order to intimately reproduce human mucosal layer and thereby, improve in vitro/in vivo correlation. [less ▲]

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See detailM Dwarf Exoplanet Surface Density Distribution: A Log-Normal Fit from 0.07-400 AU
Meyer, Michael R.; Amara, Adam; Reggiani, Maddalena ULiege et al

in Astronomy and Astrophysics Letters (2017), 1707

We fit a log-normal function to the M dwarf orbital surface density distribution of gas giant planets, over the mass range 1-10 times that of Jupiter, from 0.07-400 AU. We use a Markov Chain Monte Carlo ... [more ▼]

We fit a log-normal function to the M dwarf orbital surface density distribution of gas giant planets, over the mass range 1-10 times that of Jupiter, from 0.07-400 AU. We use a Markov Chain Monte Carlo approach to explore the likelihoods of various parameter values consistent with point estimates of the data given our assumed functional form. This fit is consistent with radial velocity, microlensing, and direct imaging observations, is well-motivated from theoretical and phenomenological viewpoints, and makes predictions of future surveys. We present probability distributions for each parameter as well as a Maximum Likelihood Estimate solution. We suggest this function makes more physical sense than other widely used functions, and explore the implications of our results on the design of future exoplanet surveys. [less ▲]

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See detailH0LiCOW - I. H0 Lenses in COSMOGRAIL's Wellspring: program overview
Suyu, S. H.; Bonvin, V.; Courbin, F. et al

in Monthly Notices of the Royal Astronomical Society (2017), 468

Strong gravitational lens systems with time delays between the multiple images allow measurements of time-delay distances, which are primarily sensitive to the Hubble constant that is key to probing dark ... [more ▼]

Strong gravitational lens systems with time delays between the multiple images allow measurements of time-delay distances, which are primarily sensitive to the Hubble constant that is key to probing dark energy, neutrino physics and the spatial curvature of the Universe, as well as discovering new physics. We present H0LiCOW (H[SUB]0[/SUB] Lenses in COSMOGRAIL's Wellspring), a program that aims to measure H[SUB]0[/SUB] with <3.5 per cent uncertainty from five lens systems (B1608+656, RXJ1131-1231, HE 0435-1223, WFI2033-4723 and HE 1104-1805). We have been acquiring (1) time delays through COSMOGRAIL and Very Large Array monitoring, (2) high-resolution Hubble Space Telescope imaging for the lens mass modelling, (3) wide-field imaging and spectroscopy to characterize the lens environment and (4) moderate-resolution spectroscopy to obtain the stellar velocity dispersion of the lenses for mass modelling. In cosmological models with one-parameter extension to flat Λ cold dark matter, we expect to measure H[SUB]0[/SUB] to <3.5 per cent in most models, spatial curvature Ω[SUB]k[/SUB] to 0.004, w to 0.14 and the effective number of neutrino species to 0.2 (1σ uncertainties) when combined with current cosmic microwave background (CMB) experiments. These are, respectively, a factor of ˜15, ˜2 and ˜1.5 tighter than CMB alone. Our data set will further enable us to study the stellar initial mass function of the lens galaxies, and the co-evolution of supermassive black holes and their host galaxies. This program will provide a foundation for extracting cosmological distances from the hundreds of time-delay lenses that are expected to be discovered in current and future surveys. [less ▲]

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See detailChanges in cannabis use in emerging adulthood: The influence of peer network, impulsivity, anxiety and depression
Glowacz, Fabienne ULiege; Schmits, Emilie ULiege

in European Review of Applied Psychology = Revue Européenne de Psychologie Appliquée (2017), 67(4), 171-179

Cannabis is the most commonly used illicit drug with the highest prevalence reported among 15- to 24-year-olds. This specific period of emerging adulthood constitutes a critical age for substance use and ... [more ▼]

Cannabis is the most commonly used illicit drug with the highest prevalence reported among 15- to 24-year-olds. This specific period of emerging adulthood constitutes a critical age for substance use and for future consumption. Cannabis use patterns change during college or university and the post-college transition; users are at greater risk of adverse health outcomes (especially if they start or maintain a pattern of frequent use). Objectives The overall aim of this study was to highlight psychological and relational factors that might be associated with changes (including cessation and fluctuation) in cannabis use during this specific period, separately for males and females. Methods The subjects were 682 first-year college students (69.94% of female), aged between 18 and 25 years (M = 18.59 years, SD = 1.56). Four groups were formed according to cannabis consumption: “non-users” (54.64%), “desisting users” (14.04%), “fluctuating users” (16.23%), and “persistent users” (15.07%). A self-report questionnaire was administered to evaluate prevalence, frequency and trajectory of use, number of peer cannabis users, alcohol use, impulsivity, anxiety (trait and social) and depression. Results Females appear more sensitive to the romantic partner's consumption than males. For both sexes, having more friends who use cannabis appears to be a determinant. Depression and anxiety were not related to changes in cannabis use. Impulsivity is a significant factor for the maintenance of cannabis use in emerging adulthood, with higher lack of premeditation for males and higher sensation seeking for females among fluctuating and persistent users. Conclusions Results are discussed in terms of maintenance of use and the spiral of consumption, including clinical implications for prevention and interventions. [less ▲]

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See detailPolarization of the changing-look quasar J1011+5442
Hutsemekers, Damien ULiege; Agis-Gonzalez, Beatriz ULiege; Sluse, Dominique ULiege et al

in Astronomy and Astrophysics (2017), 604

If the disappearance of the broad emission lines observed in changing-look quasars were caused by the obscuration of the quasar core through moving dust clouds in the torus, high linear polarization ... [more ▼]

If the disappearance of the broad emission lines observed in changing-look quasars were caused by the obscuration of the quasar core through moving dust clouds in the torus, high linear polarization typical of type 2 quasars would be expected. We measured the polarization of the changing-look quasar J1011+5442 in which the broad emission lines have disappeared between 2003 and 2015. We found a polarization degree compatible with null polarization. This measurement suggests that the observed change of look is not due to a change of obscuration hiding the continuum source and the broad line region, and that the quasar is seen close to the system axis. Our results thus support the idea that the vanishing of the broad emission lines in J1011+5442 is due to an intrinsic dimming of the ionizing continuum source that is most likely caused by a rapid decrease in the rate of accretion onto the supermassive black hole. Based on observations made with the William Herschel telescope operated on the island of La Palma by the Isaac Newton Group of Telescopes in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. [less ▲]

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See detailProbing the atmosphere of a sub-Jovian planet orbiting a cool dwarf
Sedaghati, Elyar; Boffin, Henri M. J.; Delrez, Laetitia et al

in Monthly Notices of the Royal Astronomical Society (2017), 468

We derive the 0.01 $\mu$m binned transmission spectrum, between 0.74 and 1.0 $\mu$m, of WASP-80b from low resolution spectra obtained with the FORS2 instrument attached to ESO's Very Large Telescope. The ... [more ▼]

We derive the 0.01 $\mu$m binned transmission spectrum, between 0.74 and 1.0 $\mu$m, of WASP-80b from low resolution spectra obtained with the FORS2 instrument attached to ESO's Very Large Telescope. The combination of the fact that WASP-80 is an active star, together with instrumental and telluric factors, introduces correlated noise in the observed transit light curves, which we treat quantitatively using Gaussian Processes. Comparison of our results together with those from previous studies, to theoretically calculated models reveals an equilibrium temperature in agreement with the previously measured value of 825K, and a sub-solar metallicity, as well as an atmosphere depleted of molecular species with absorption bands in the IR ($\gg 5\sigma$). Our transmission spectrum alone shows evidence for additional absorption from the potassium core and wing, whereby its presence is detected from analysis of narrow 0.003 $\mu$m bin light curves ($\gg 5\sigma$). Further observations with visible and near-UV filters will be required to expand this spectrum and provide more in-depth knowledge of the atmosphere. These detections are only made possible through an instrument-dependent baseline model and a careful analysis of systematics in the data. [less ▲]

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See detailViolences conjugales et justice pénale: un couple à problémes ? Introduction au dossier
Glowacz, Fabienne ULiege; Vanneste, Charlotte ULiege

in Champ Pénal = Penal Field (2017), Vol. XIV | 2017

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See detailMultiple uprising invasions of Pelophylax water frogs, potentially inducing a new hybridogenetic complex
Dufresne, Christophe; Denoël, Mathieu ULiege; Di Santo, Lionel et al

in Scientific Reports (2017), 7

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to ... [more ▼]

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to reconstruct the scenario of an uprising invasion of the famous water frogs (Pelophylax) in southern France, through a fine-scale genetic survey. We identified three different taxa over less than 200 km2: the autochthonous P. perezi, along with the alien P. ridibundus and P. kurtmuelleri, which have suddenly become invasive. As a consequence, the latter hybridizes and may now form a novel hybridogenetic complex with P. perezi, which could actively promote its replacement. This exceptional situation makes a textbook application of genetics to early-detect, monitor and understand the onset of biological invasions before they pose a continental-wide threat. It further emphasizes the alarming rate of amphibian translocations, both at global and local scales, as well as the outstanding invasive potential of Pelophylax aliens. [less ▲]

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See detailThe Poetics of (In)visibility: A Stylistic Analysis of Caryl Phillips's Foreigners: Three English Lives
Tunca, Daria ULiege

in Ariel : A Review of International English Literature (2017), 48(3-4), 159-186

Caryl Phillips’s multi-voiced texts have often been studied through the lens of Bakhtinian polyphony. In this essay, I focus on the volume of fictionalized biographies Foreigners: Three English Lives ... [more ▼]

Caryl Phillips’s multi-voiced texts have often been studied through the lens of Bakhtinian polyphony. In this essay, I focus on the volume of fictionalized biographies Foreigners: Three English Lives (2007) to demonstrate that the polyphonic nature of Phillips’s work resides not only in the structural confrontation of characters’ and narrators’ voices but also in the inscription of the writer’s own subjectivity within these individual discourses. Borrowing methods from the discipline of stylistics, I first focus on the use of adjectives and modality in the opening section of Foreigners, “Dr. Johnson’s Watch,” to establish how the first-person narrator’s gradual transition from tentativeness to self-confidence constitutes a way for the implied author, on the one hand, to expose the thwarted logic of the colonially-tinted discourse of his eighteenth-century narrator and, on the other, to offer larger reflections on the process of ideological encoding inherent in the writing of historiography. Such an investigation based on modality furthers allow me to challenge the critical consensus according to which the second section of the book, “Made in Wales,” is a straightforward factual account. Indeed, I suggest that the story of the rise and fall of mixed-race boxer Randolph Turpin is in fact a highly polyphonic narrative featuring increasingly marked clashes in modality and point of view. These, I argue, may draw attention precisely to the problematic construction of historiographical discourse deceptively made to appear so commonsense by the narrator of “Dr. Johnson’s Watch.” [less ▲]

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See detailAverage first-passage time of a quasi-Hamiltonian Mathieu oscillator with parametric and forcing excitations
Vanvinckenroye, Hélène ULiege; Denoël, Vincent ULiege

in Journal of Sound and Vibration (2017)

A linear oscillator simultaneously subjected to stochastic forcing and parametric excitation is considered. The time required for this system to evolve from a low initial energy level until a higher ... [more ▼]

A linear oscillator simultaneously subjected to stochastic forcing and parametric excitation is considered. The time required for this system to evolve from a low initial energy level until a higher energy state for the first time is a random variable. Its expectation satisfies the Pontryagin equation of the problem, which is solved with the asymptotic expansion method developed by Khasminskii. This allowed deriving closed-form expressions for the expected first passage time. A comprehensive parameter analysis of these solutions is performed. Beside identifying the important dimensionless groups governing the problem, it also highlights three important regimes which are called incubation, multiplicative and additive because of their specific features. Those three regimes are discussed with the parameters of the problem. [less ▲]

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See detailRéalisation du attelle de Thomas modifiée pour un membre antérieur
Maquet, Celine ULiege; Casalta, Hélène ULiege; Touati, Kamal ULiege et al

in Point Vétérinaire (2017), 377

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See detailStructural Basis for Plant Plasma Membrane Protein Dynamics and Organization into Functional Nanodomains
Gronnier, Julien; Crowet, Jean-Marc ULiege; Habenstein, Birgit et al

in eLife (2017), 6

Plasma Membrane is the primary structure for adjusting to ever changing conditions. PM sub-compartmentalization in domains is thought to orchestrate signalling cascades. Yet, mechanisms governing membrane ... [more ▼]

Plasma Membrane is the primary structure for adjusting to ever changing conditions. PM sub-compartmentalization in domains is thought to orchestrate signalling cascades. Yet, mechanisms governing membrane organization are mostly uncharacterized. The plant-specific proteins REMORINs are factors regulating hormonal crosstalk and host invasion. REMs are the best-characterized PM nanodomain markers targeted to the PM via an uncharacterized moiety called REMORIN C-terminal Anchor. By coupling biophysical methods, super-resolution microscopy and physiology, we decipher an original mechanism regulating the dynamic and organization of nanodomains. We showed that PM targeting is independent of the COP II-dependent secretory pathway and mediated by PI4P and sterol. REM-CA is an unconventional lipid-binding motif that confers nanodomain organization. Analyses of REM-CA mutants by single particle tracking demonstrate that mobility and supramolecular organization are critical for immunity. This study provides a unique mechanistic insight into how the tight control of spatial segregation is critical in the definition of PM domain necessary to support biological function. [less ▲]

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See detailOptimisation of Ship and Offshore Structures and Effective Waterway Infrastructures to Support the Global Economic Growth of a Country/Region
Rigo, Philippe ULiege; Bayatfar, Abbas ULiege; Buldgen, Loïc ULiege et al

in Ship Science & Technology (2017), 11

This paper is the written support of Prof. Ph. Rigo for his keynote lecture at the 5th International Congress for Ship Design and Naval Engineering (March 2017, Columbia). After presenting of the main ... [more ▼]

This paper is the written support of Prof. Ph. Rigo for his keynote lecture at the 5th International Congress for Ship Design and Naval Engineering (March 2017, Columbia). After presenting of the main research activities at ANAST, ULG, he discussed the way to improve the effectiveness of waterway infrastructures to support the global economic growth of a country/region. This paper includes the following parts:  Ship Structure Optimization: methodology to perform ship scantling optimization, decreasing steel weight and keeping the production cost at an acceptable level. We first review the links between “Design” and “Optimization” and secondly define the place of “Ship Structure Optimization” within the general framework of a “Ship Optimization”.  Ship impacts (Collision), with applications to navigation lock and dry dock gates: these gates have to be designed taking into account accidental loads, such as ship collisions. A new simplified analytical method is proposed, based on the so-called super-element method. This method was developed to rapidly assess the crashworthiness of the collided structure and avoid high computational effort of numerical simulations.  Inland waterway Navigation and the development in South America of Inland Waterway Classifications.  EMSHIP, European ERASMUS MUNDUS education program (www.emship.eu): the unique master in Ship & Offshore Structures awarded by the prestigious European Erasmus Mundus Program. Indeed, EMSHIP shares the outstanding experiences of educators, trainers, industrial partners and students in the rapidly developing areas of marine and offshore engineering industry. [less ▲]

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