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[more ▼]This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow. Blade Element Momentum Theory (BEMT), Vortex Lattice Method (VLM) and momentum theory for oblique flow are used to predict propeller performance. For validation, the predictions for a commonly used propeller for VTOL MAVs are compared to a set of wind tunnel experiments. Both BEMT and VLM succeed in predicting correct trends of the forces and moments acting upon the propeller shaft, although accuracy decreases significantly in oblique flow. For the dataset analysed here, combining the available data of the propeller in purely axial flow with momentum theory for oblique flow and applying a correction factor for the wake skew angle results in more accurate performance estimates at all elevation angles. [less ▲]Detailed reference viewed: 80 (13 ULg) Les pouvoirs publics et les édifices cultuels en BelgiqueHusson, Jean-François in Revue du Droit des Religions (2017), (3), 61-78The Belgian regime of relations between the State and religious or philosophical communities results notably in financial supports for buildings used for worship and moral counselling. These interventions ... [more ▼]The Belgian regime of relations between the State and religious or philosophical communities results notably in financial supports for buildings used for worship and moral counselling. These interventions are essentially a legacy of the French Concordat, largely unchallenged by the regionalization process. Today, it has to respond to contrasting situations between religions recognized in the 19th century – generally declining – and more recently recognized ones – generally expanding –. An additional complication originates in differences in ownership of the buildings or their classification as listed buildings. After presenting the situation by religious and philosophical community and level of power, this paper questions the equity of the system and addresses the possible developments. [less ▲]Detailed reference viewed: 25 (4 ULg) Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometryEchterbille, Julien; Gilles, Nicolas; Araoz, Romulo et alin Toxicon (2017), 130Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]Detailed reference viewed: 30 (6 ULg) Calibration and testing of wide-field UV instrumentsFrey, Harald; Mende, Stephen; Loicq, Jerôme et alin Journal of Geophysical Research. Space Physics (2017), 122As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations ... [more ▼]As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations difficult is the need for working in vacuum substantially extending the required time and effort compared to visible systems. In theory a ray tracing and characterization of each individual component of the optical system (mirrors, windows, and grating) should provide the transmission efficiency of the combined system. However, potentially unknown effects (contamination, misalignment, and measurement errors) can make the final error too large and unacceptable for most applications. Therefore, it is desirable to test and measure the optical properties of the whole system in vacuum and compare the overall response to the response of a calibrated photon detector. A proper comparison then allows the quantification of individual sources of uncertainty and ensures that the whole instrument performance is within acceptable tolerances or pinpoints which parts fail to meet requirements. Based on the experience with the IMAGE Spectrographic Imager, the Wide-band Imaging Camera, and the ICON Far Ultraviolet instruments, we discuss the steps and procedures for the proper radiometric sensitivity and passband calibration, spot size, imaging distortions, flatfield, and field of view determination. [less ▲]Detailed reference viewed: 19 (1 ULg) Intergroup variation in robbing and bartering by long-tailed macaques at Uluwatu Temple (Bali, Indonesia)Brotcorne, Fany ; Giraud, Gwennan; Gunst, Noelle et alin Primates : Journal of Primatology (2017)Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the ... [more ▼]Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the macaques appear to use them as tokens, returning them to humans in exchange for food. While extensively studied in captivity, our research is the first to investigate the object/food exchange between humans and primates in a natural setting. During a 4-month study in 2010, we used both focal and event sampling to record 201 RB events in a population of long-tailed macaques (Macaca fascicularis), including four neighboring groups ranging freely around Uluwatu Temple, Bali (Indonesia). In each group, we documented the RB frequency, prevalence and outcome, and tested the underpinning anthropogenic and demographic determinants. In line with the environmental opportunity hypothesis, we found a positive qualitative relation at the group level between time spent in tourist zones and RB frequency or prevalence. For two of the four groups, RB events were significantly more frequent when humans were more present in the environment. We also found qualitative partial support for the male-biased sex ratio hypothesis [i.e., RB was more frequent and prevalent in groups with higher ratios of (sub)adult males], whereas the group density hypothesis was not supported. This preliminary study showed that RB is a spontaneous, customary (in some groups), and enduring population-specific practice characterized by intergroup variation in Balinese macaques. As such, RB is a candidate for a new behavioral tradition in this species. [less ▲]Detailed reference viewed: 24 (7 ULg) Régimes matrimoniaux et effets patrimoniaux des partenariats enregistrés en Europe. Propos introductifsWautelet, Patrick in Droit de la famille (2017), 22(5), 10-13Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des ... [more ▼]Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des questions ouvertes qu'ils posent [less ▲]Detailed reference viewed: 58 (2 ULg) Continental Climate Gradients in North America and Western Eurasia before and after the Closure of the Central American SeawayUtescher, Torsten; Dreist, Andreas; Henrot, Alexandra-Jane et alin Earth and Planetary Science Letters (2017), 472Detailed reference viewed: 8 (2 ULg) From distant neighbours to bedmates: Exploring the synergies between the social economy and sustainable developmentHudon, Marek; Huybrechts, Benjamin in Annals of Public and Cooperative Economics (2017), 88(2), 141-154To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two ... [more ▼]To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two research fields and the increasing combination of these fields in the literature. Several avenues through which social enterprises can contribute to the transition towards sustainable development are then identified. This is followed by a discussion of how and why the combination can be particularly fruitful both for the social economy and for sustainability transition movements. We also highlight some important challenges facing the social economy with regard to its contribution to sustainable development. Finally we introduce the papers that constitute this special issue and show how they contribute, individually and collectively, to a better understanding of the increasing linkage between the social economy and sustainable development. [less ▲]Detailed reference viewed: 71 (5 ULg) Experimental passive flutter suppression using a linear tuned vibration absorberVerstraelen, Edouard ; Habib, Giuseppe ; Kerschen, Gaëtan et alin AIAA Journal (2017), 55(5), 1707-1722The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be ... [more ▼]The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be increased flexibility, which in turn can lead to un- favourable aeroelastic phenomena involving large amplitude oscillations and non- linear effects such as geometric hardening and stall flutter. Vibration mitigation is one of the approaches currently under study for avoiding these phenomena. In the present work, passive vibration mitigation is applied to a nonlinear experimental aeroelastic system by means of a linear tuned vibration absorber. The aeroelastic apparatus is a pitch and flap wing that features a continuously hardening restoring torque in pitch and a linear restoring torque in flap. Extensive analysis of the sys- tem with and without absorber at pre-critical and post-critical airspeeds showed an improvement in flutter speed of around 36%, a suppression of a jump due to stall flutter, and a reduction in LCO amplitude. Mathematical modelling of the exper- imental system is used to demonstrate that optimal flutter delay is achieved when two of the system modes flutter at the same flight condition. Nevertheless, even this optimal absorber quickly loses effectiveness as it is detuned. The wind tunnel mea- surements showed that the tested absorbers were much slower to lose effectiveness than those of the mathematical predictions. [less ▲]Detailed reference viewed: 116 (34 ULg) Martian mesospheric cloud observations by IUVSon MAVEN: Thermal tides coupled to the upper atmosphereStevens; Siskind; Evans et alin Geophysical Research Letters (2017), 44The manuscript describes the observation of Martian mesosphericclouds between 60 and 80 km altitude by the Imaging Ultraviolet Spectrograph (IUVS) on NASA’sMAVEN spacecraft. The cloud observations are ... [more ▼]The manuscript describes the observation of Martian mesosphericclouds between 60 and 80 km altitude by the Imaging Ultraviolet Spectrograph (IUVS) on NASA’sMAVEN spacecraft. The cloud observations are uniquely obtained at early morning local times, whichcomplement previous observations obtained primarily later in the diurnal cycle. Differences in thegeographic distribution of the clouds from IUVS observations indicate that the local time is crucial for theinterpretation of mesospheric cloud formation. We also report concurrent observations of upperatmospheric scale heights near 170 km altitude, which are diagnostic of temperature. These observationssuggest that the dynamics enabling the formation of mesospheric clouds propagate all the way to theupper atmosphere. [less ▲]Detailed reference viewed: 16 (3 ULg) Two-qubit entangling gates between distant atomic qubits in a latticeCesa, Alexandre ; Martin, John in Physical Review A (2017), 95Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two ... [more ▼]Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two-qubit conditional gates between nearest-neighbor qubits in the array can be implemented by exploiting the Rydberg blockade mechanism, as was shown by D. Jaksch et al. [Phys. Rev. Lett. 85, 2208 (2000)]. However, the energy shift due to dipole-dipole interactions causing the blockade falls off rapidly with the interatomic distance, and protocols based on direct Rydberg blockade typically fail to operate between atoms separated by more than one lattice site. In this work, we propose an extension of the protocol of Jaksch et al. for controlled-Z and controlled-NOT gates which works in the general case where the qubits are not nearest neighbors in the array. Our proposal relies on the Rydberg excitation hopping along a chain of ancilla noncoding atoms connecting the qubits on which the gate is to be applied. The dependence of the gate fidelity on the number of ancilla atoms, the blockade strength, and the decay rates of the Rydberg states is investigated. A comparison between our implementation of a distant controlled-NOT gate and one based on a sequence of nearest-neighbor two-qubit gates is also provided. [less ▲]Detailed reference viewed: 41 (7 ULg) Gestion d’un cas de brûlure étendue suite à une chirurgie de convenancePicavet, Pierre ; Jacobs, Morgane ; Noël, Stéphanie et alin Monde Vétérinaire (Le) (2017), 169Detailed reference viewed: 9 (2 ULg) Testing a general approach to assess the degree of disturbance in tropical forestsSellan, Giacomo; Simini, Filippo; Maritan, Amos et alin Journal of Vegetation Science (2017), 28(3), 459668Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of ... [more ▼]Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of disturbance? Location: Reserve of Yangambi, northeast region of the Democratic Republic of Congo. Methods: We applied an allometricmodel based on the assumption that a vir- tually undisturbed forest uses all available resources. In this condition, the forest structure (e.g. the tree size distribution) is theoretically predictable fromthe scal- ing of the tree crown with tree height at an individual level. The degree of dis- turbance can be assessed through comparing the slopes of the tree size distribution curves in the observed and predicted conditions. We tested this tool in forest stands subjected to different degrees of disturbance. We inventoried trees >1.3 m in height by measuring the DBH in three plots of 1 ha each, and measured tree height, crownradius and crownlength in a sub-sample of trees. Results: All tree species, independently of the site, shared the same exponents of allometric relationships: tree height vs tree diameter, crown radius vs tree height, crown length vs tree height and consequently crown volume vs tree height, suggesting that similar trajectories of biomass allocation have evolved irrespective of species. The observed tree size distributions appeared to be power laws (excluding the finite size effect) and, as predicted, the slope was steeper in the less disturbed forest (?2.34) compared to the most disturbed (?1.99). The difference in the slope compared to the theoretical fully functional forest (?2.65) represents the metric for assessing the degree of disturbance. Conclusions: We developed a simple tool for operationalizing the concept of ‘disturbance’ in tropical forests. This approach is species-independent, needs minimal theoretical assumptions, the measurement of only a few structural traits and requires a low investment in equipment, time and computer skills. Its simple implementation opens new perspectives for effectively addressing initiatives of forest protection and/or restoration. [less ▲]Detailed reference viewed: 31 (11 ULg) Ultrasonic roll bite measurements in cold rolling: Contact length and strip thicknessCarretta, Yves; Hunter, Andrew; Boman, Romain et alin Proceedings of the Institution of Mechanical Engineers - Part J - Journal of Engineering Tribology (2017)In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip ... [more ▼]In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, online process measurements are usually carried out; such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area. This paper presents a sensor capable of monitoring strip thickness variations as well as roll bite length in situ and in real time. The sensor emits ultrasonic pulses that reflect from the interface between the roll and the strip. Both the time-of-flight of the pulses and the reflection coefficient (the ratio of the amplitude of the reflected signal to that of the incident signal) are recorded. The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under several lubrication conditions. Strip thickness variation and roll-bite length obtained from the experimental data agree well with numerical results computed with a cold rolling model in the mixed lubrication regime. [less ▲]Detailed reference viewed: 39 (4 ULg) Origin of the counterintuitive dynamic charge in the transition metal dichalcogenidesPike, Nicholas ; Van Troeye, Benoit; Dewandre, Antoine et alin Physical Review B (2017), 95Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we ... [more ▼]Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we investigate their static and dynamic charges. The dynamic charge of the transition metal dichalcogenides with trigonal symmetry are anomalously large, while in their hexagonally symmetric counterparts, we even observe a counterintuitive sign, i.e., the transition metal takes a negative charge, opposite to its static charge. This phenomenon, so far never remarked on or analyzed, is understood by investigating the perturbative response of the system and by investigating the hybridization of the molecular orbitals near the Fermi level. Furthermore, a link is established between the sign of the Born effective charge and the process of π backbonding from organic chemistry. Experiments are proposed to verify the calculated sign of the dynamical charge in these materials. Employing a high-throughput search we also identify other materials that present counterintuitive dynamic charges. [less ▲]Detailed reference viewed: 26 (3 ULg) Merci à vous!RADERMECKER, Régis in Revue de l'Association Belge du Diabète (2017), 60(3), Detailed reference viewed: 35 (2 ULg) Finite element model reduction for space thermal analysisJacques, Lionel ; Béchet, Eric ; Kerschen, Gaëtan in Finite Elements in Analysis and Design (2017), 127To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]Detailed reference viewed: 42 (5 ULg) Discovery and pharmacological characterization of succinate receptor (SUCNR1/GPR91) agonistsGeubelle, Pierre ; Gilissen, Julie; Dilly, Sebastien et alin British Journal of Pharmacology (2017), 174(9), 796-808Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho ... [more ▼]Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho)physiological processes, the function of SUCNR1 has remained elusive because no pharmacological tools were available. We report on the discovery of the first family of synthetic potent agonists. Experimental Approach We screened a library of succinate analogues and analysed their activity on SUCNR1. In addition, we modelled a pharmacophore and a binding site for the receptor. New agonists were identified based on the information provided by these two approaches. Their activity was studied in various bioassays, including measurement of cAMP levels, [Ca2+]i mobilisation, TGF-α shedding and recruitment of arrestin 3. The in vivo impact of SUCNR1 activation by these new agonists was evaluated on rat blood pressure. Key Results We identified cis-epoxysuccinic acid and cis-1,2-cyclopropanedicarboxylic acid as agonists with an efficacy similar to the one of succinic acid. Interestingly, cis-epoxysuccinic acid was characterized by a 10 to 20 fold higher potency than succinate on the receptor. For example, cis-epoxysuccinic acid reduced cAMP levels with a pEC50 = 5.57 ± 0.02 (EC50 = 2.7 μM) as compared to succinate pEC50 = 4.54 ± 0.08 (EC50 = 29 μM). The rank order of potency of the three agonists was the same in all bioassays tested. In vivo, cis-epoxysuccinic and cis-1,2-cyclopropanedicarboxylic acid increased rat blood pressure to the same extent as succinate did. Conclusions and Implications We provide new agonist tools for SUCNR1 that should facilitate further research on this understudied receptor. [less ▲]Detailed reference viewed: 41 (6 ULg) Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotidesDelierneux, Céline ; Donis, Nathalie ; servais, laurence et alin Journal of Thrombosis and Haemostasis (2017), 15(5), 983-997Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment ... [more ▼]Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment. Unexpectedly, a recent study indicates that CpG ODNs activate human platelets via the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptor glycoprotein VI. Objective: To further analyze the mechanisms of CpG ODN-induced platelet activation and identify potential inhibitory strategies. Methods: In vitro analyses were performed on human and mouse platelets, and on cell lines expressing platelet ITAM receptors. CpG ODN platelet activating effects were evaluated in a mouse model of thrombosis. Results: We demonstrated platelet uptake of CpG ODNs, resulting in platelet activation and aggregation. The C-type lectin-like receptor 2 (CLEC-2) expressed in DT40 cells bound CpG ODNs. CpG ODN uptake did not occur in CLEC-2-deficient mouse platelets. Inhibition of human CLEC-2 with a blocking antibody inhibited CpG ODN-induced platelet aggregation. CpG ODNs caused CLEC-2 dimerization, and provoked its internalization. They induced dense granule release before the onset of aggregation. Accordingly, pretreating platelets with apyrase, or inhibiting P2Y12 with cangrelor or clopidogrel prevented CpG ODN platelet activating effect. In vivo, intravenously injected CpG ODN interacted with platelets adhered to mouse injured endothelium, and promoted thrombus growth, which was inhibited by CLEC-2 deficiency or by clopidogrel. Conclusions: CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis and might be targeted to prevent adverse events in patients at risk. [less ▲]Detailed reference viewed: 36 (16 ULg) Comparative assessment of 6-[18F]fluoro-L-m-tyrosine and 6-[18F]fluoro-L-dopa to evaluate dopaminergic presynaptic integrity in a Parkinson’s disease rat model.Becker, Guillaume ; Bahri, Mohamed Ali ; Michel, Anne et alin Journal of Neurochemistry (2017), 141Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical ... [more ▼]Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the pre-clinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [18F]fluoro-3,4-dihydroxyphenyl-L-alanine ([18F]FDOPA) and 6-[18F]fluoro-L-m-tyrosine ([18F]FMT). Because the imaging signal is theoretically less contaminated by metabolites, we hypothesized that the latter would show stronger relationship with behavioural and post-mortem measures of striatal dopaminergic deficiency. We used a within-subject design to measure striatal [18F]FMT and [18F]FDOPA uptake in eight partially lesioned, eight fully lesioned and ten sham-treated rats. Animals were pretreated with an L-aromatic amino acid decarboxylase (AADC) inhibitor. A catechol-O-methyl transferase inhibitor was also given before [18F]FDOPA PET. Quantitative estimates of striatal uptake were computed using conventional graphical Patlak method. Striatal dopaminergic deficiencies were measured with apomorphine-induced rotations and post-mortem striatal DA content. We observed a strong relationship between [18F]FMT and [18F]FDOPA estimates of decreased uptake in the denervated striatum using the tissue-derived uptake rate constant Kc. However, only [18F]FMT Kc succeeded to discriminate between the partial and the full 6-OHDA lesion and correlated well with the post-mortem striatal DA content. This study indicates that the [18F]FMT could be more sensitive, with respect of [18F]FDOPA, to investigate DA terminals loss in 6-OHDA rats, and open the way to in vivo AADC activity targeting in future investigations on progressive PD models. [less ▲]Detailed reference viewed: 37 (7 ULg) PRTEE et épicondyliteJanssen, Arnaud; Kaux, Jean-François in Kinésithérapie du Sport Information (2017), (2ème trimestre 2017), 4-7Detailed reference viewed: 21 (2 ULg) Unravelling fluvial deposition and pedogenesis in ephemeral stream deposits in the vicinity of the prehistoric rock shelter of Ifri n'Ammar (NE Morocco) during the last 100 kaBartz, Melanie; Rixhon; Kehl, Martin et alin Catena (2017), 152Detailed reference viewed: 37 (7 ULg) The internet as a source of information used by women after childbirth to meet their need for information: A web-based survey.Slomian, Justine ; Bruyère, Olivier ; Reginster, Jean-Yves et alin Midwifery (2017), 48OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to ... [more ▼]OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to meet their need of information; (c) to describe how the respondents evaluate the reliability of the information found; (d) to understand how the information found on the Internet affects women's decision-making; and (e) to appreciate how health professionals react to the information found by the women. DESIGN: this study used a large web-based survey that was widely broadcasted on various websites and social networks. SETTING AND PARTICIPANTS: belgian women who had a child under 2 years old and who agreed to participate were included in the study. FINDINGS: 349 questionnaires were valid for analyses. After childbirth, 90.5% of women admitted to using the Internet to seek information about themselves or about their baby, regardless of socioeconomic status or age. There were various reasons for seeking information on the Internet, but the most frequent reason the women expressed was to find information 'on their own' (88.1%). The most searched for topic was breastfeeding. The women believed that the information was quite useful (82.7%) but they assigned an average score of 5.3 out of 10 for the quality of the information they found on the Internet. Approximately 80% of the women felt that the Internet helped them control a decision that they made 'a little', 'often' or 'very often'. Professionals are not always willing to talk about information found on the Internet with mothers. Therefore, many women believed that health professionals should suggest reliable Internet websites for new mothers. CONCLUSIONS: the integration of the Internet and new technologies could be a useful tool during postpartum management. [less ▲]Detailed reference viewed: 20 (7 ULg) La déficience en hormone lutéinisante: ses conséquences sur la reproductionVALDES SOCIN, Hernan Gonzalo ; potorac, iulia; LIBIOULLE, Cécile et alin Urologic (2017), 13(1), 18-23En physiologie de la reproduction, il est bien établi que les hormones glycoprotéiques hypophysaires LH (hormone lutéinisante) et FSH régulent de concert la production de stéroïdes sexuels (indispensables ... [more ▼]En physiologie de la reproduction, il est bien établi que les hormones glycoprotéiques hypophysaires LH (hormone lutéinisante) et FSH régulent de concert la production de stéroïdes sexuels (indispensables à la virilisation et à la féminisation) ainsi que la gamétogenèse (spermatogenèse chez l’homme et folliculogenèse chez la femme). La sécrétion des gonadotrophines hypophysaires est à son tour stimulée par quelque 1.500 neurones hypothalamiques à GnRH (gonadotrophin releasing hormone) et inhibée par la GnIH (gonadotrophin nhibitory hormone), récemment identifiée (1). En amont de la GnRH, un ensemble de neuropeptides hypothalamiques tels que les kisspeptines, la neuroquinine B, la dinorphine, la leptine, etc., modulent sa sécrétion (Figure 1). Ces neuropeptides intègrent les différents signaux internes et de l’environnement, nécessaires à la puberté et, par la suite, à la reproduction. En corollaire de ces données physiologiques, les patients porteurs de mutations invalidant les gènes de la GnRH, des neuropeptides décrits et de leurs récepteurs souffrent d’un hypogonadisme hypogonadotrope. Ces patients présentent un déficit plus ou moins sévère de la sécrétion combinée de LH et de FSH (2, 3). Il a fallu attendre des observations rares, telles que des mutations de la sous-unité beta (β) de l’hormone lutéinisante, pour comprendre la contribution spécifique et isolée de cette hormone à la reproduction. Dans cet article, nous synthétisons les données historiques et récentes sur la déficience en hormone lutéinisante et ses conséquences sur la reproduction. [less ▲]Detailed reference viewed: 28 (7 ULg) Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytesDemine, Stéphane; Tejerina, Silvia; Bihin, Benoît et alin Journal of Cellular Physiology (2017)Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet ... [more ▼]Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet-associated proteins as well as lipolytic enzymes have been identified. Increasing energy expenditure by inducing a mild uncoupling of mitochondria in adipocytes might represent a putative interesting anti-obesity strategy as it reduces the adipose tissue triacylglycerol content (limiting alterations caused by cell hypertrophy) by stimulating lipolysis through yet unknown mechanisms, limiting the adverse effects of adipocyte hypertrophy. Herein, the molecular mechanisms involved in lipolysis induced by a mild uncoupling of mitochondria in white 3T3-L1 adipocytes were characterized. Mitochondrial uncoupling-induced lipolysis was found to be independent from canonical pathways that involve lipolytic enzymes such as HSL and ATGL. Finally, enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles. This new mechanism of triacylglycerol breakdown in adipocytes exposed to mild uncoupling provides new insights on the biology of adipocytes dealing with mitochondria forced to dissipate energy. [less ▲]Detailed reference viewed: 15 (2 ULg) Modelling the influence of strain localisation and viscosity on the behaviour of underground drifts drilled in claystonePardoen, Benoît ; Collin, Frédéric in Computers and Geotechnics (2017), 85Detailed reference viewed: 30 (3 ULg) Première consultation ambulatoire du nouveau-néRIGO, Vincent ; PIELTAIN, Catherine ; Schoffeniels, Colombe et alin Revue Médicale de Liège (2017), 72(5), 253-259The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate ... [more ▼]The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate feedings are checked. Sudden infant death syndrome prevention and security advices are reminded. Realisation of both neonatal dried blood screen and hearing test is confirmed, as well as planning of specific follow-up appointments. The physical exam will focus on red flags for diseases or malformations with a delayed presentation. [less ▲]Detailed reference viewed: 27 (7 ULg) Sustainability Accounting and Control for Smart City - Special Issue - Call for PapersCrutzen, Nathalie ; Van Bockhaven, Jonas; Schaltegger, Stefan et alin sustainability accounting, management and policy journal (2017)Detailed reference viewed: 314 (1 ULg) Modeling the strain localization around an underground gallery with a hydro-mechanical double scale model; effect of anisotropyvan den Eijnden, AP; Bésuelle, Pierre; Collin, Frédéric et alin Computers and Geotechnics (2017), 85Detailed reference viewed: 50 (2 ULg) Transparent Electrodes Based on Silver Nanowire Networks: From Physical Considerations towards Device IntegrationBellet, Daniel; Lagrange, Mélanie; Sannicolo, Thomas et alin Materials (2017), 10The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells ... [more ▼]The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells, flexible light-emitting devices, touch screens, electromagnetic devices, and flexible transparent thin film heaters. Currently, the most commonly used TCM for such applications (ITO: Indium Tin oxide) suffers from two major drawbacks: brittleness and indium scarcity. Among emerging transparent electrodes, silver nanowire (AgNW) networks appear to be a promising substitute to ITO since such electrically percolating networks exhibit excellent properties with sheet resistance lower than 10 Ω/sq and optical transparency of 90%, fulfilling the requirements of most applications. In addition, AgNW networks also exhibit very good mechanical flexibility. The fabrication of these electrodes involves low-temperature processing steps and scalable methods, thus making them appropriate for future use as low-cost transparent electrodes in flexible electronic devices. This contribution aims to briefly present the main properties of AgNW based transparent electrodes as well as some considerations relating to their efficient integration in devices. The influence of network density, nanowire sizes, and post treatments on the properties of AgNW networks will also be evaluated. In addition to a general overview of AgNW networks, we focus on two important aspects: (i) network instabilities as well as an efficient Atomic Layer Deposition (ALD) coating which clearly enhances AgNW network stability and (ii) modelling to better understand the physical properties of these networks. [less ▲]Detailed reference viewed: 13 (2 ULg) Advanced method optimization for volatile aroma profiling of beer using two-dimensional gas chromatography time-of-flight mass spectrometryStefanuto, Pierre-Hugues ; Perrault, Katelynn ; Dubois, Lena et alin Journal of Chromatography. A (2017)The complex mixture of volatile organic compounds (VOCs) present in the headspace of Trappist and craft beers was studied to illustrate the efficiency of thermal desorption (TD) comprehensive two ... [more ▼]The complex mixture of volatile organic compounds (VOCs) present in the headspace of Trappist and craft beers was studied to illustrate the efficiency of thermal desorption (TD) comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS) for highlighting subtle differences between highly complex mixtures of VOCs. Headspace solid-phase microextraction (HS-SPME), multiple (and classical) stir bar sorptive extraction (mSBSE), static headspace (SHS), and dynamic headspace (DHS) were compared for the extraction of a set of 21 representative flavor compounds of beer aroma. A Box-Behnken surface response methodology experimental design optimization (DOE) was used for convex hull calculation (Delaunay’s triangulation algorithms) of peak dispersion in the chromatographic space. The predicted value of 0.5 for the ratio between the convex hull and the available space was 10% higher than the experimental value, demonstrating the usefulness of the approach to improve optimization of the GC × GC separation. Chemical variations amongst aligned chromatograms were studied by means of Fisher Ratio (FR) determination and F‐distribution threshold filtration at different significance levels (α = 0.05 and 0.01) and based on z‐score normalized area for data reduction. Statistically significant compounds were highlighted following principal component analysis (PCA) and hierarchical cluster analysis (HCA). The dendrogram structure not only provided clear visual information about similarities between products but also permitted direct identification of the chemicals and their relative weight in clustering. The effective coupling of DHS-TD-GC × GC-TOFMS with PCA and HCA was able to highlight the differences and common typical VOC patterns among 24 samples of different Trappist and selected Canadian craft beers. [less ▲]Detailed reference viewed: 25 (5 ULg) The exclusion of competing one-way essential complements: implications for net neutralityBroos, Sébastien ; Gautier, Axel in International Journal of Industrial Organization (2017), 52We analyze the incentives of internet service providers (ISPs) to break net neutrality by excluding competing one-way essential complements, i.e. internet applications competing with their own products. A ... [more ▼]We analyze the incentives of internet service providers (ISPs) to break net neutrality by excluding competing one-way essential complements, i.e. internet applications competing with their own products. A typical example is the exclusion of VoIP applications by telecom companies offering internet and voice services. A monopoly ISP may want to exclude a competing internet app if it is of inferior quality and the ISP cannot ask for a surcharge for its use. Competition between ISPs never leads to full app exclusion but it may lead to a fragmented internet where only one ISP offers the application. We show that, both in monopoly and duopoly, prohibiting the exclusion of the app and surcharges for its use does not always improve welfare. [less ▲]Detailed reference viewed: 82 (19 ULg) Diversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformaticsDegueldre, Michel; Verdenaud, Marion; Garikoitz, Legarda et alin Toxicon (2017), 130Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top ... [more ▼]Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from Conus venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species. [less ▲]Detailed reference viewed: 21 (2 ULg) Isotopic half-life and enrichment factor in two species of European freshwater fish larvae: an experimental approachLatli, Adrien; Sturaro, Nicolas ; Dujardin, Nelson et alin Rapid Communications in Mass Spectrometry (2017), 31(8), 685-692RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue ... [more ▼]RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue enrichment factor (TEF) and half-life (HL). We experimentally compared TEF and HL in two freshwater fish larvae. We hypothesised that chub had a better growth/tissue replacement ratio than roach, due to the use of a food closer to their natural diet. METHODS: We determined the isotopic HL, the TEF and the contribution of growth or metabolic tissue replacement to dynamic isotopic incorporation. After yolk sac resorption, larvae were fed for 5 weeks with prey similar to their natural diet (Artemia nauplii) up to the isotopic equilibrium followed by Chironomid larvae. Stable isotope measurements were carried out using a continuous flow isotope ratio mass spectrometer coupled to an elemental analyser. RESULTS: Changes in isotopic composition strongly followed the predictions of exponential growth and time-dependent models. The isotopic HL varied between 8.2 and 12.6 days and the TEF of nitrogen and carbon ranged from 1.7 to 2.1‰ and from –0.9 to 1.2 ‰, respectively. The incorporation of dietary 13C was due more to the production of new tissue (between 56 and 79%) than to the metabolic process. Chub allocated more energy to growth than roach and the Chironomidae diet contributed more to the consumers’ growth than the Artemia diet. CONCLUSIONS: Metabolic rates seemed lower for chub than for roach, especially when they were fed with Chironomidae. A Chironomidae-based diet would be more profitable to chub, and the high associated growth rate could increase the development of the fish larvae. The HL and TEF were in the range of those reported in the literature. These results will be helpful for field-based studies, because they can help to increase the accuracy of models. [less ▲]Detailed reference viewed: 41 (8 ULg) Effect of growth rate on the physical and mechanical properties of Douglas-fir in Western EuropePolet, Caroline; Henin, Jean-Marc; Hebert, Jacques et alin Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2017), 47To quantify the impact of forest management and tree growth rate on the potential uses of Douglas-fir wood, nine physico-mechanical properties were studied on more than 1250 standardized clear specimens ... [more ▼]To quantify the impact of forest management and tree growth rate on the potential uses of Douglas-fir wood, nine physico-mechanical properties were studied on more than 1250 standardized clear specimens. These were collected from trees cut in 11 even-aged stands (6 trees/stand) located in Wallonia (Southern Belgium). Stands were 40 to 69 years old and the mean tree girth was ca. 150 cm. The mean ring width of the 66 trees ranged from 3 to more than 7 mm. Statistical analysis evidenced significant but weak effects of ring width. So, mean ring width and cambial age of the specimens considered jointly only explain 28 to 40% of the variability of the properties studied. From a purely technological standpoint, maintaining mean ring width under 4 mm/year in juvenile wood and 6 mm/year in mature wood should allow all potential uses of Douglas-fir wood. Our results and the literature demonstrate, however, the importance of genetic selection as a complement of silvicultural measures to improve or guarantee the technological properties of Douglas-fir wood. [less ▲]Detailed reference viewed: 14 (1 ULg) Photosensitive polydimethylsiloxane networks for adjustable-patterned filmsJellali, Rachid; Alexandre, Michaël; Jérôme, Christine in Polymer Chemistry (2017), 8(16), 2499-2508Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV ... [more ▼]Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV light having a wavelength of above 300 nm, multifunctional coumarin-PDMSs are transformed into covalent networks via [2 + 2] photocycloaddition of two coumarin moieties forming a cyclobutane ring. Taking advantage of the possible localized irradiation through a photomask, a novel concept to generate patterned PDMS films with various surface topologies was demonstrated. This concept is based on the combination of a low molar mass difunctional PDMS with a multifunctional PDMS of a high molar mass forming a photoreversible network allowing osmotic diffusion of a linear PDMS-coumarin of low mole- cular weight in a loosely crosslinked network. Advantageously, illumination by a light source at 254 nm induces the photocleavage of the cyclobutane cross-links offering some photo-induced reversibility to the PDMS network. These novel photo-responsive networks are interesting for several applications, in photo-adaptable biomedical implants (particularly photo-adjustable intra-ocular lenses), photo-tuneable patterned microsystems (e.g. for microfluidics) and photo-switchable controlled release systems. [less ▲]Detailed reference viewed: 33 (5 ULg) X-LAG: How did they grow so tall?BECKERS, Albert ; Rostomyan, Liliya ; Potorac, Iulia et alin Annales d'Endocrinologie (2017)X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset ... [more ▼]X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset occurring before the age of 5 in all cases described to date, which is significantly younger than in other forms of pituitary gigantism. These patients have mixed GH and prolactin positive adenomas and/or mixed-cell hyperplasia and highly elevated levels of GH/IGF-1 and prolactin. Given their particularly young age of onset, the significant GH hypersecretion can lead to a phenotype of severe gigantism with very advanced age-specific height Z-scores. If not adequately treated in childhood, this condition results in extreme final adult height. XLAG has a clinical course that is highly similar to some of the tallest people with gigantism in history. « X-linked acrogigantism » (XLAG) est un syndrome pédiatrique récemment décrit, lié à des microduplications du chromosome Xq26.3, englobant le gène GPR101, responsable de l’affection. Les patients XLAG présentent un phénotype remarquablement distinct des autres cas de gigantisme hypophysaire. Dans tous les cas décrits, la maladie s’exprime avant 5 ans soit beaucoup plus tôt que dans les autres formes. Les patients ont habituellement un gros adénome ou une hyperplasie mixte pour la GH et la prolactine et des taux très élevés de GH/IGF1 et prolactine. En raison de son début très précoce, l’hypersécrétion importante de GH peut conduire à un gigantisme extrêmement sévère avec un Z-score très important pour l’âge. Si cette condition n’est pas traitée pendant l’enfance, elle peut conduire à une taille finale extrême. XLAG montre une évolution clinique similaire à celle observée chez les géants les plus grands de l’histoire. [less ▲]Detailed reference viewed: 19 (11 ULg) Pressure flaking to serrate bifacial points for the hunt during the MIS5 at Sibudu Cave (South Africa)Rots, Veerle ; Lentfer, Carol ; Schmid, Viola C. et alin PLoS ONE (2017), 12(4), 0175151Detailed reference viewed: 24 (4 ULg) Reconstructions of the 1900–2015 Greenland ice sheet surface mass balance using the regional climate MAR modelFettweis, Xavier ; Box, Jason; Agosta, Cécile et alin Cryosphere (The) (2017), 11With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional ... [more ▼]With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional; version 3.5.2) model with the ERA-Interim (ECMWF Interim Re-Analysis; 1979–2015), ERA-40 (1958–2001), NCEP–NCARv1 (National Centers for Environmental Prediction–National Center for Atmospheric Research Reanalysis version 1; 1948–2015), NCEP–NCARv2 (1979–2015), JRA-55 (Japanese 55-year Reanalysis; 1958–2014), 20CRv2(c) (Twentieth Century Reanalysis version 2; 1900–2014) and ERA-20C (1900–2010) reanalyses. While all these forcing products are reanalyses that are assumed to represent the same climate, they produce significant differences in the MAR-simulated SMB over their common period. A temperature adjustment of +1 °C (respectively −1 °C) was, for example, needed at the MAR boundaries with ERA-20C (20CRv2) reanalysis, given that ERA-20C (20CRv2) is ∼ 1 °C colder (warmer) than ERA-Interim over Greenland during the period 1980–2010. Comparisons with daily PROMICE (Programme for Monitoring of the Greenland Ice Sheet) near-surface observations support these adjustments. Comparisons with SMB measurements, ice cores and satellite-derived melt extent reveal the most accurate forcing datasets for the simulation of the GrIS SMB to be ERA-Interim and NCEP–NCARv1. However, some biases remain in MAR, suggesting that some improvements are still needed in its cloudiness and radiative schemes as well as in the representation of the bare ice albedo. Results from all MAR simulations indicate that (i) the period 1961–1990, commonly chosen as a stable reference period for Greenland SMB and ice dynamics, is actually a period of anomalously positive SMB (∼ +40 Gt yr−1) compared to 1900–2010; (ii) SMB has decreased significantly after this reference period due to increasing and unprecedented melt reaching the highest rates in the 120-year common period; (iii) before 1960, both ERA-20C and 20CRv2-forced MAR simulations suggest a significant precipitation increase over 1900–1950, but this increase could be the result of an artefact in the reanalyses that are not well-enough constrained by observations during this period and (iv) since the 1980s, snowfall is quite stable after having reached a maximum in the 1970s. These MAR-based SMB and accumulation reconstructions are, however, quite similar to those from Box (2013) after 1930 and confirm that SMB was quite stable from the 1940s to the 1990s. Finally, only the ERA-20C-forced simulation suggests that SMB during the 1920–1930 warm period over Greenland was comparable to the SMB of the 2000s, due to both higher melt and lower precipitation than normal. [less ▲]Detailed reference viewed: 103 (21 ULg) Resolved astrometric orbits of ten O-type binariesLe Bouquin, J.-B.; Sana, H.; Gosset, Eric et alin Astronomy and Astrophysics (2017), 601Our long term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2 ... [more ▼]Our long term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2). We follow-up ten O+O binaries with AMBER, PIONIER and GRAVITY at the VLTI. Here, we report about 130 astrometric observations over the last 7 years. We combine this dataset with distance estimates to compute the total mass of the systems. We also compute preliminary individual component masses for the five systems with available SB2 radial velocities. Nine over the ten binaries have their three dimensional orbit well constrained. Four of them are known colliding wind, non-thermal radio emitters, and thus constitute valuable targets for future high angular resolution radio imaging. Two binaries break the correlation between period and eccentricity tentatively observed in previous studies. It suggests either that massive star formation produce a wide range of systems, or that several binary formation mechanisms are at play. Finally, we found that the use of existing SB2 radial velocity amplitudes can lead to unrealistic masses and distances. If not understood, the biases in radial velocity amplitudes will represent an intrinsic limitation for estimating dynamical masses from SB2+interferometry or SB2+Gaia. Nevertheless, our results can be combined with future Gaia astrometry to measure the dynamical masses and distances of the individual components with an accuracy of 5 to 15\%, completely independently of the radial velocities. [less ▲]Detailed reference viewed: 33 (5 ULg) Size and shape variations of the bony components of sperm whale cochleaeSchnitzler, Joseph ; Frederich, Bruno ; Früchtnicht, Sven et alin Scientific Reports (2017), 7Several mass strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled around 48h after their discovery on German coasts of ... [more ▼]Several mass strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled around 48h after their discovery on German coasts of Schleswig Holstein. The present study aims to explore the morphological variation of the primary sensory organ of sperm whales, the left and right auditory system, using high-resolution computerised tomography imaging. We performed a quantitative analysis of size and shape of cochleae using landmark-based geometric morphometrics to reveal inter-individual anatomical variations. A hierarchical cluster analysis based on thirty-one external morphometric characters classified these 12 individuals in two stranding clusters. A relative amount of shape variation could be attributable to geographical differences among stranding locations and clusters. Our geometric data allowed the discrimination of distinct bachelor schools among sperm whales that stranded on German coasts. We argue that the cochleae are individually shaped, varying greatly in dimensions and that the intra-specific variation observed in the morphology of the cochleae may partially reflect their affiliation to their bachelor school. There are increasing concerns about the impact of noise on cetaceans and describing the auditory periphery of odontocetes is a key conservation issue to further assess the effect of noise pollution. [less ▲]Detailed reference viewed: 14 (3 ULg) The growth and meat quality of H'mong chicken raised by industrial farmingNguyen Van Duy, ; Vu Dinh, Ton; Nguyen Thi, Phuongin Journal of Sciences of Agriculture Vietnams (2017), 15(4), 438-445This study was carried out at the experimental farm of Vietnam National University of Agriculture from January to December, 2016 on H’mong chickens that were raised by industrial farming. H’mong chickens ... [more ▼]This study was carried out at the experimental farm of Vietnam National University of Agriculture from January to December, 2016 on H’mong chickens that were raised by industrial farming. H’mong chickens were raised in three lots in order to observe the survival rate, growth capacity, FCR and quality of meat. The results show that Hmong chicken adapted well with industrial farming method, which supposedly contributed to the improvement in survival rate of chickens (94,1%) compared to traditional free-range farming method.. H'mong chickens have low weight and considerable growth speed. Average daily gain of H’mong chickens was increasing gradually from one to ten weeks of age and then decreasing. From one to 12 weeks, H'mong chickens consumes averagely 24.81 grams of feed per day and Feed Conversation Rate was 3.1 kg of feed/kg live body weight. Twelve week-old roosters and hens achieved body weight at 1206,7g and 1026,7g in respectively. H'mong chicken is a dual-purpose breed, producing an amount of thigh meat 1.3 times greater than breast meat. The proportion of iron in Hmong chicken meat is higher than that in other domestic chicken breeds and there are eight unsubstituted amino acids in the meat. Key works: H’mong chickens, industrial farming. [less ▲]Detailed reference viewed: 14 (0 ULg) Organometallic-mediated radical polymerization of 'less activated monomers': fundamentals, challenges and opportunitiesDebuigne, Antoine ; Jérôme, Christine ; Detrembleur, Christophe in Polymer (2017), 115Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the ... [more ▼]Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the double bond of these monomers. This Feature Article summarizes substantial progress in the organometallic-mediated radical polymerization (OMRP) of this important class of monomers including vinyl esters, olefins, vinyl chloride, vinyl amides, or ionic-liquid vinyl monomers. It aims to provide a clear and comprehensive account of the fundamentals and challenges in the OMRP of LAMs as well as an overview of the resulting macromolecular engineering opportunities. The input of photochemistry, environmentally friendly solvents or flow reactors in OMRP is also presented. Finally, it emphasizes how some well-defined LAMs-based materials contributed to the development of specific applications notably in the fields of biomedicine or energy. [less ▲]Detailed reference viewed: 72 (22 ULg) Group B Streptococcus and perinatal mortalityCOOLS, Piet; MELIN, Pierrette in Research in Microbiology (2017), 17The World Health Organization estimates that every year, one million neonatal deaths occur because of neonatal infection. Furthermore, an equal number of stillbirths are thought to be caused by infections ... [more ▼]The World Health Organization estimates that every year, one million neonatal deaths occur because of neonatal infection. Furthermore, an equal number of stillbirths are thought to be caused by infections. Here we discuss the role of Streptococcus agalactiae (group B Streptococcus, GBS) in neonatal disease and stillbirth. [less ▲]Detailed reference viewed: 20 (1 ULg) The recent warming trend in North GreenlandOrsi, A.; Kawamura, K.; Masson-Delmotte, V. et alin Geophysical Research Letters (2017)The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric ... [more ▼]The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric reanalyses are relatively unconstrained in this region, resulting in a large spread of estimated 30-year recent warming trends, which limits their use to investigate the mechanisms responsible for this trend. Here, we present a surface temperature reconstruction over 1982-2011 at NEEM (51∘ W, 77∘ N), in North Greenland, based on the inversion of borehole temperature and inert gas isotope data. We find that NEEM has warmed by 2.7±0.33∘C over the past 30 years, from the long-term 1900-1970 average of -28.55±0.29∘C. The warming trend is principally caused by an increase in downward longwave heat flux. Atmospheric reanalyses underestimate this trend by 17%, underlining the need for more in situ observations to validate reanalyses. [less ▲]Detailed reference viewed: 33 (4 ULg) Vortex Lattice simulations of attached and separated flows around flapping wingsLambert, Thomas ; Abdul Razak, Norizham; Dimitriadis, Grigorios in Aerospace (2017), 4(2), 22Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads ... [more ▼]Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads acting on flapping wings are of interest for designing such aircraft and optimising thrust production. In this work, the unsteady Vortex Lattice method is used in conjunction with three load estimation techniques in order to predict the aerodynamic lift and drag time histories produced by flapping rectangular wings. The load estimation approaches are the Katz, Joukowski and simplified Leishman-Beddoes techniques. The simulations' predictions are compared to experimental measurements from a flapping and pitching wing presented by Razak and Dimitriadis [1]. Three types of kinematics are investigated, pitch-leading, pure flapping and pitch lagging. It is found that pitch-leading tests can be simulated quite accurately using either the Katz or Joukowski approaches as no measurable flow separation occurs. For the pure flapping tests, the Katz and Joukowski techniques are accurate as long as the static pitch angle is greater than zero. For zero or negative static pitch angles these methods underestimate the amplitude of the drag. The Leishman-Beddoes approach yields better drag amplitudes but can introduce a constant negative drag offset. Finally, for the pitch-lagging tests the Leishman-Beddoes technique is again more representative of the experimental results, as long as flow separation is not too extensive. Considering the complexity of the phenomena involved, in the vast majority of cases the lift time history is predicted with reasonable accuracy. The drag (or thrust) time history is more challenging. [less ▲]Detailed reference viewed: 46 (14 ULg) Bayesian estimation of genetic parameters for individual feed conversion and body weight gain in meat quailDA COSTA CAETANO, GIOVANI; REIS MOTA, Rodrigo ; ALVES DA SILVA, DELVAN et alin Livestock Science (2017), 200We estimated genetic correlations between partial and total body weight gain (BWG) and individual feed conversion (FC) aiming to identify possible partial traits as selection criteria in meat quail ... [more ▼]We estimated genetic correlations between partial and total body weight gain (BWG) and individual feed conversion (FC) aiming to identify possible partial traits as selection criteria in meat quail breeding programs. Data included 379 records from two diﬀerent genetic lines (188 quails from UFV1 and 191 from UFV2). The following traits were evaluated:individual feed conversion from21to28(FC21–28)andfrom28to35daysofage (FC28–35); body weight gain from 1 to 21 (BWG1–21), 21–28 (BWG21–28), 28–35 (BWG28–35) and from 1 to 35 (BWG1–35, full period) days of age. Genetic parameters (heritabilities and genetic correlations) were estimated through multi-trait models via Bayesian inference. For UFV1 line, genetic correlations estimates (with respective credible intervals) between BWG1–21 and BWG1–35, BWG21–28 and BWG1–35, BWG28–35 and BWG1–35, FC21–28 and FC28–35, FC 21–28 and BWG1–35, and FC28–35 and BWG1–35 were 0.62 0.15–0.90), 0.81 0.60–0.94), 0.69 0.35–0.88), 0.06 (−050 to 0.60), −0.87 (−0.97 to −0.63) and −0.51 (−0.84 to −0.01), respectively; and for UFV2 line, these estimates were 0.33 (−0.05 to 0.63), 0.79 0.59–0.92), 0.88 0.73–0.96), 0.35 (−0.30 to 0.78), −0.56 (−0.85 to −0.09) and −0.76 (−0.93 to −0.41), respectively. Additionally, for the UFV1 line heritability estimates for BWG21–28 and FC21–28 were 0.69 0.40–0.86) and 0.55 0.31–0.74), respectively; while for UFV2 line the heritabilities for BWG28–35 and FC28–35 were 0.68 0.47–0.83) and 0.37 0.17–0.63). Based on these results, we recommend as target traits BWG21–28 and FC21–28 for UFV1 line; and BWG28–35 for UFV2 line. Selecting for these indicated traits, we expect to reduce breeding program costs related mainly to feeding of nonselected animals and labor with phenotyping. [less ▲]Detailed reference viewed: 13 (2 ULg) Scaling Theory of the Anderson Transition in Random Graphs: Ergodicity and UniversalityGarcia-Mata, Ignacio; Giraud, Olivier; Georgeot, Bertrand et alin Physical Review Letters (2017), 118We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that ... [more ▼]We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that a single transition separates a localized phase from an unusual delocalized phase that is ergodic at large scales but strongly nonergodic at smaller scales. In the critical regime, multifractal wave functions are located on a few branches of the graph. Different scaling laws apply on both sides of the transition: a scaling with the linear size of the system on the localized side, and an unusual volumic scaling on the delocalized side. The critical scalings and exponents are independent of the branching parameter, which strongly supports the universality of our results. [less ▲]Detailed reference viewed: 23 (8 ULg) Use of a metagenetic approach to monitor the bacterial microbiota of “Tomme d’Orchies” cheese during the ripening processCeugniez, Alexandre; Taminiau, Bernard ; Coucheney, Françoise et alin International Journal of Food Microbiology (2017), 247The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade ... [more ▼]The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade, particularly those performed on milk and cheese derivative products. In this work, we investigated the bacterial content of "Tomme d'Orchies" cheese, an artisanal pressed and uncooked French cheese. To this end, a metagenetic analysis, using Illumina technology, was utilized on samples taken from the surface and core of the cheese at 0, 1, 3, 14 and 21 days of ripening process. In addition to the classical microbiota found in cheese, various strains likely from environmental origin were identified. A large difference between the surface and the core content was observed within samples withdrawn during the ripening process. The main species encountered in the core of the cheese were Lactococcus spp. and Streptococcus spp., with an inversion of this ratio during the ripening process. Less than 2.5% of the whole population was composed of strains issued from environmental origin, as Lactobacillales, Corynebacterium and Brevibacterium. In the core, about 85% of the microbiota was attributed to the starters used for the cheese making. In turn, the microbiota of the surface contained less than 30% of these starters and interestingly displayed more diversity. The predominant genus was Corynebacterium sp., likely originating from the environment. The less abundant microbiota of the surface was composed of Bifidobacteria, Brevibacterium and Micrococcales. To summarize, the “Tomme d’Orchies” cheese displayed a high diversity of bacterial species, especially on the surface, and this diversity is assumed to arise from the production environment and subsequent ripening process. [less ▲]Detailed reference viewed: 33 (8 ULg) Assessment of bacterial superficial contamination in classical or ritually slaughtered cattle using metagenetics and microbiological analysisKorsak Koulagenko, Nicolas ; Taminiau, Bernard ; Hupperts, Caroline et alin International Journal of Food Microbiology (2017), 247The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological ... [more ▼]The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological procedures and 16S rDNA metagenetics. The purpose was also to investigate the neck area to identify bacteria originating from the digestive or the respiratory tract. Twenty bovine carcasses (10 from each group) were swabbed at the slaughterhouse, where both slaughtering methods are practiced. Two swabbing areas were chosen: one “legal” zone of 1,600 cm2 (composed of zones from rump, flank, brisket and forelimb) and locally on the neck area (200 cm2). Samples were submitted to classical microbiology for aerobic Total Viable Counts (TVC) at 30°C and Enterobacteriaceae counts, while metagenetic analysis was performed on the same samples. The classical microbiological results revealed no significant differences between both slaughtering practices; with values between 3.95 and 4.87 log CFU/100 cm2 and 0.49 and 1.94 log CFU/100 cm2, for TVC and Enterobacteriaceae respectively. Analysis of pyrosequencing data showed that differences in the bacterial population abundance between slaughtering methods were mainly observed in the “legal” swabbing zone compared to the neck area. Bacterial genera belonging to the Actinobacteria phylum were more abundant in the “legal” swabbing zone in “Halal” samples, while Brevibacterium and Corynebacterium were encountered more in “Halal” samples, in all swabbing areas. This was also the case for Firmicutes bacterial populations (families of Aerococcaceae, Planococcaceae). Except for Planococcoceae, the analysis of Operational Taxonomic Unit (OTU) abundances of bacteria from the digestive or respiratory tract revealed no differences between groups. In conclusion, the slaughtering method does not influence the superficial microbiological pattern in terms of specific microbiological markers of the digestive or respiratory tract. However, precise analysis of taxonomy at the genus level taxonomy highlights differences between swabbing areas. Although not clearly proven in this study, differences in hygiene practices used during both slaughtering protocols could explain the differences in contamination between carcasses from both slaughtering groups. [less ▲]Detailed reference viewed: 39 (20 ULg) Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibitionHendrick, Elodie ; Peixoto, Paul; Blomme, Arnaud et alin Oncogene (2017)Detailed reference viewed: 38 (3 ULg) L'arrêt de la Cour de cassation du 24 novembre 2016 en matière de funding lossDelforge, Cécile in Chroniques Notariales (2017)Detailed reference viewed: 9 (0 ULg) Vers une (r)évolution du renseignement belge : la nécessaire émergence d'une communauté du renseignementLeroy, Patrick in Revue "Diplomatie" (2017)Le renseignement belge entre dans une période de (r)évolution amenée par la crise des attentats qui secouent le sol européen. La tentations est grande pour les décideurs politiques de palier les "failles ... [more ▼]Le renseignement belge entre dans une période de (r)évolution amenée par la crise des attentats qui secouent le sol européen. La tentations est grande pour les décideurs politiques de palier les "failles" du renseignement par des mesures radicales qui pourraient atteindre l'ADN, le coeur de métier du renseignement. [less ▲]Detailed reference viewed: 45 (6 ULg) Oxidative wear behaviour of laser clad high speed steel thick deposits: influence of sliding speed, carbide type and morphologyHashemi, Seyedeh Neda ; Mertens, Anne ; Montrieux, Henri-Michel et alin Surface & Coatings Technology (2017), 315The oxidative wear behaviour of four different High Speed Steel (HSS) thick coatings (one cast material and three laser clad deposits with varying Mo, V and W contents) was investigated using a pin-on ... [more ▼]The oxidative wear behaviour of four different High Speed Steel (HSS) thick coatings (one cast material and three laser clad deposits with varying Mo, V and W contents) was investigated using a pin-on-disc tribometer at two different sliding speeds of 10cm/s and 50cm/s. Microstructural characterisation (before and after the wear tests) was carried out by SEM and wear debris was analysed by XRD. For all four materials, the oxide layer was formed of hard and brittle haematite-type α-Fe2O3, prone to break and release debris that acted as a third body, thus increasing sample wear. The laser clad HSS materials exhibited a higher wear resistance than their conventional cast counterpart, thanks to their finer microstructures. In particular, the coarser MC and M2C carbides present in the cast material were sensitive to cracking during the wear tests, releasing debris that contributed to increased third body abrasion together with oxide fragments. A detailed comparison of the wear behaviour of the three laser clad deposits, in correlation with their different microstructures, further demonstrated that harder V-rich MC carbides offered better wear resistance compared to the softer W-rich M2C carbides. The morphology of the carbides also played a role in determining the wear resistance at the higher sliding speed of 50 cm/s. Clover-shaped primary MC carbides resisted wear better than angular ones due to their better geometric anchoring. Similarly, the geometric anchoring of eutectic M2C carbides, forming a quasi-continuous network at the grain boundaries of the matrix, proved beneficial at higher sliding speed. [less ▲]Detailed reference viewed: 46 (22 ULg) Extracting residues from stone tools for optical analysis: towards an experiment-based protocolCnuts, Dries ; Rots, Veerle in Archaeological and Anthropological sciences (2017)The identification of residues is traditionally based on the distinctive morphologies of the residue fragments by means of light microscopy. Most residue fragments are amorphous, in the sense that they ... [more ▼]The identification of residues is traditionally based on the distinctive morphologies of the residue fragments by means of light microscopy. Most residue fragments are amorphous, in the sense that they lack distinguishing shapes or easily visible structures under reflected light microscopy. Amorphous residues can only be identified by using transmitted light microscopy, which requires the extraction of residues from the tool’s surface. Residues are usually extracted with a pipette or an ultrasonic bath in combination with distilled water. However, a number of researchers avoid residue extraction because it is unclear whether current extraction techniques are representative for the use-related residue that adheres to a flaked stone tool. In this paper, we aim at resolving these methodological uncertainties by critically evaluating current extraction methodologies. Attention is focused on the variation in residue types, their causes of deposition and their adhesion and on the most successful technique for extracting a range of residue types from the stone tool surface. Based on an experimental reference sample in flint, we argue that a stepwise extraction protocol is most successful in providing rep- resentative residue extractions and in preventing damage, destruction or loss of residue. [less ▲]Detailed reference viewed: 25 (1 ULg) Liver microbiome of Peromyscus leucopus, a key reservoir host species for emerging infectious diseases in North AmericaAndré, Adrien ; Mouton, Alice ; millien, virginie et alin Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (2017)Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiomeusing next generation ... [more ▼]Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiomeusing next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). The Lactobacillus genus was found to dominate the liver microbiome.We also detected a large proportion of individuals infected by Bartonella vinsonii arupensis, a human pathogenic bacteria responsible for endocarditis, aswell as Borrelia burgdorferi, the pathogen responsible for Lyme disease in North America. We then compared the microbiomes among two P. leucopus genetic clusters occurring on either side of the St. Lawrence River, and did not detect any effect of the host genotype on their liver microbiome assemblage. Finally, we report, for the first time, the presence of B. burgdorferi in a smallmammal host fromthe northern side of the St. Lawrence River, in support of models that have predicted the northern spread of Lyme disease in Canada. [less ▲]Detailed reference viewed: 19 (5 ULg) Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effectsEhx, Grégory ; Fransolet, Gilles ; De Leval, Laurence et alin Oncoimmunology (2017)The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading ... [more ▼]The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg). Here, we investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) and graft-versus-leukemia effects in a humanized murine model of transplantation (human PBMCs-infused NSG mice), and described the impact of the drug on human T cells in vivo. We observed that AZA improved both survival and xGVHD scores. Further, AZA significantly decreased human T-cell proliferation as well as IFN-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA significantly increased Treg frequency through hypomethylation of FOXP3i1 as well as increased Treg proliferation. The later was subsequent to higher STAT5 signaling in Treg from AZA-treated mice, which resulted from higher IL-2 secretion by conventional T cells from AZA-treated mice itself secondary to demethylation of the IL-2 gene promoter by AZA. Importantly, Tregs harvested from AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Finally, graft-versus-leukemia effects (assessed by growth inhibition of THP-1 cells, transfected to express the luciferase gene) were not abrogated by AZA. In summary, our data demonstrate that AZA prevents xGVHD without abrogating graft-versus-leukemia effects. These findings could serve of basis for further studies of GVHD prevention by AZA in acute myeloid leukemia patients offered an allogeneic transplantation. [less ▲]Detailed reference viewed: 18 (4 ULg) Docking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP) – Insights into a non-canonical and fuzzy interactionBessonov, Kyrylo ; Harauz, George; Vassall, Kenrickin Proteins (2017)The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence ... [more ▼]The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily-dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a “sandwich”-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the β-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the β-sheets in Fyn-SH3 and proline-rich region of MBP. [less ▲]Detailed reference viewed: 33 (9 ULg) Substrate Induced Strain Field in FeRh Epilayers Grown on Single Crystal MgO (001) SubstratesBarton, C. W.; Ostler, Thomas ; Huskisson, D. et alin Scientific Reports (2017), 7Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new ... [more ▼]Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new possibilities for creating multifunctional magnetic and spintronic devices which can utilise both thermal and applied eld energy to change state and functionalise composites. A key requirement in realising multifunctional devices is the need to understand and control the properties of FeRh in the extreme thin lm limit (tFeRh < 10 nm) where interfaces are crucial. Here we determine the properties of FeRh lms in the thickness range 2.5–10 nm grown directly on MgO substrates. Our magnetometry and structural measurements show that a perpendicular strain eld exists in these thin films which results in an increase in the phase transition temperature as thickness is reduced. Modelling using a spin dynamics approach supports the experimental observations demonstrating the critical role of the atomic layers close to the MgO interface. [less ▲]Detailed reference viewed: 30 (3 ULg) Unguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata.Campos, Pierre-Eric; Wolfender, Jean-Luc; Quieroz, Emerson F. et alin Journal of Natural Products (2017), 80Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four ... [more ▼]Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four pentacyclic alkaloids, ptilomycalins E-H (2-5), along with four known compounds: crambescidin 800 (6) and crambescidin 359 (7), crambescidic acid (8), and fromiamycalin (9). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E (2) and the mixture of the new ptilomycalins G (4) and H (5) showed promising cytotoxicity against KB cells with IC50 values of 0.85 and 0.92 μM, respectively. Ptilomycalin F (3) and fromiamycalin (9) exhibited promising activity against Plasmodium falciparum with IC50 values of 0.23 and 0.24 μM, respectively [less ▲]Detailed reference viewed: 35 (4 ULg) Surgical management of ectopic ureters in dogs: clinical outcome and prognostic factors for long-term continenceNoël, Stéphanie ; Claeys, Stéphanie ; Hamaide, Annick in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (2017)Detailed reference viewed: 15 (3 ULg) The effect of concentrate allocation on traffic and milk production of pasture based cows milked by an automatic milking systemLessire, Françoise ; Froidmont, Eric; Shortall, John et alin Animal (2017), 11(4), 1-9Increased economic, societal and environmental challenges facing agriculture are leading to a greater focus on effective way to combine grazing and automatic milking systems (AMS). One of the fundamental ... [more ▼]Increased economic, societal and environmental challenges facing agriculture are leading to a greater focus on effective way to combine grazing and automatic milking systems (AMS). One of the fundamental aspects of robotic milking is cows’ traffic to the AMS. Numerous studies have identified feed provided, either as fresh grass or concentrate supplement, as the main incentive for cows to return to the robot. The aim of this study was to determine the effect of concentrate allocation on voluntary cow traffic from pasture to the robot during the grazing period, to highlight the interactions between grazed pasture and concentrate allocation in terms of substitution rate and the subsequent effect on average milk yield and composition. Thus, 29 grazing cows, milked by a mobile robot, were monitored for the grazing period (4 months). They were assigned to 2 groups: a low concentrate (LC) group (15 cows) and a high concentrate (HC) group (14 cows) receiving 2 kg and 4 kg concentrate per cow per day respectively. Two allocations per day of fresh pasture were provided at 0700h and 1600h. The cows had to go through the AMS to receive the fresh pasture allocation. The effect of concentrate level on robot visitation was calculated by summing milkings, refusals and failed milkings/cow per day. The impact on average daily milk yield and composition was also determined. The interaction between lactation number and month was used as an indicator of pasture availability. Concentrate allocation increased significantly robot visitations in HC (3.60 ± 0.07 visitations/cow per day in HC - 3.10 ± 0.07 visitations/cow per day in LC; P<0.001) while milkings/cow per day were similar in both groups (LC: 2.37 ± 0.02/day - HC: 2.39 ± 0.02/day; ns). The average daily milk yield over the grazing period was enhanced in HC (22.39 ± 0.22 kg/cow per day in HC- 21.33 ± 0.22 kg/cow per day in LC; P<0.001). However the gain in milk due to higher concentrate supply was limited with regards to the amount of provided concentrates. Milking frequency in HC primiparous compared with LC was increased. In the context of this study, considering high concentrate levels as an incentive for robot visitation might be questioned, as it had no impact on milking frequency and limited impact on average milk yield and composition. By contrast, increased concentrate supply could be targeted specifically to primiparous cows. [less ▲]Detailed reference viewed: 34 (11 ULg) WASP-167b/KELT-13b: Joint discovery of a hot Jupiter transiting a rapidly-rotating F1V starTemple, L. Y.; Hellier, C.; Albrow, M. D. et alin ArXiv e-prints (2017), 1704We report the joint WASP/KELT discovery of WASP-167b/KELT-13b, a transiting hot Jupiter with a 2.02-d orbit around a $V$ = 10.5, F1V star with [Fe/H] = 0.1 $\pm$ 0.1. The 1.5 R$_{\rm Jup}$ planet was ... [more ▼]We report the joint WASP/KELT discovery of WASP-167b/KELT-13b, a transiting hot Jupiter with a 2.02-d orbit around a $V$ = 10.5, F1V star with [Fe/H] = 0.1 $\pm$ 0.1. The 1.5 R$_{\rm Jup}$ planet was confirmed by Doppler tomography of the stellar line profiles during transit. We place a limit of $<$ 8 M$_{\rm Jup}$ on its mass. The planet is in a retrograde orbit with a sky-projected spin-orbit angle of $\lambda = -165^{\circ} \pm 5^{\circ}$. This is in agreement with the known tendency for orbits around hotter stars to be more likely to be misaligned. WASP-167/KELT-13 is one of the few systems where the stellar rotation period is less than the planetary orbital period. We find evidence of non-radial stellar pulsations in the host star, making it a $\delta$-Scuti or $\gamma$-Dor variable. The similarity to WASP-33, a previously known hot-Jupiter host with pulsations, adds to the suggestion that close-in planets might be able to excite stellar pulsations. [less ▲]Detailed reference viewed: 7 (4 ULg) Het Belgische interneringsbeleid als een voorbeeld van hybride bestuurPans, Maurice; Darcis, Coralie ; Leys, Mark et alin Tijdschrift voor Bestuurswetenschappen en Publiekrecht (2017), 4Het domein van de zorg voor geïnterneerde personen kent internationaal een omslag. Naast de “criminalisering” van personen met een psychiatrische stoornis die criminele feiten begaan, ontwikkelen er zich ... [more ▼]Het domein van de zorg voor geïnterneerde personen kent internationaal een omslag. Naast de “criminalisering” van personen met een psychiatrische stoornis die criminele feiten begaan, ontwikkelen er zich nieuwe visies en zorgperspectieven op de kwaliteit van leven en de re-integratie in de maatschappij van zowel personen met psychische kwetsbaarheid als geïnterneerde personen. Tot zeer recent werden geïnterneerde personen bijna exclusief benaderd als personen die misdaden of misdrijven hebben gepleegd waar ze door hun psychische stoornis niet voor verantwoordelijk konden worden gesteld. De onderliggende logica van de aanpak was sterk geënt op een model waarbij opsluiting en isolatie van de maatschappij centraal stonden omwille van misdaad. Geïnterneerde personen werden om die reden opgesloten in een gevangenissysteem volgens een justitiële benadering. Het behandelings- en zorgperspectief raakte hierbij ondergesneeuwd. De “criminalisering” van personen met psychische stoornissen heeft in België historisch geleid tot inadequate aanpak en begeleiding van deze groep patiënten. Meerdere veroordelingen van de Belgische Staat door het Europees Hof voor de Rechten van de Mens (EHRM), overvolle gevangenissen, het gebrek aan somatische en psychiatrische gezondheidszorg binnen gevangenissen en psychiatrische annexen en aanbevelingen van het Europees Comité voor de Preventie van Foltering en Onmenselijke of Vernederende Behandeling of Bestraffing (CPT) zijn directe aanleidingen voor het Masterplan Internering (juni 2016) en de wet van 5 mei 2014 betreffende de internering van personen . In deze bijdrage staan we stil bij het Masterplan Internering van 2016 en de nieuwe Interneringswet van 5 mei 2014. We proberen te duiden op welke manier in beide bronnen randvoorwaarden worden gecreëerd voor een hybride bestuursvorm in de sector. We staan kort stil bij beleidsmatige en juridische ontwikkelingen die vooraf gingen. [less ▲]Detailed reference viewed: 25 (4 ULg) 18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma: A case report.Liu, Willy; Delwaide, Jean ; BLETARD, Noëlla et alin World Journal of Hepatology (2017), 9(11), 562-566Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and ... [more ▼]Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an 18FDG up-take. [less ▲]Detailed reference viewed: 21 (4 ULg) Size fractionation as a tool for separating charcoal of different fuel source and recalcitrance in the wildfire ash layerMastrolonardo, Giovanni in Science of the Total Environment (2017), 595Charcoal is a heterogeneous material exhibiting a diverse range of properties. This variability represents a serious challenge in studies that use the properties of natural charcoal for reconstructing ... [more ▼]Charcoal is a heterogeneous material exhibiting a diverse range of properties. This variability represents a serious challenge in studies that use the properties of natural charcoal for reconstructing wildfires history in terrestrial ecosystems. In this study, we tested the hypothesis that particle size is a sufficiently robust indicator for separating forest wildfire combustion products into fractions with distinct properties. For this purpose, we examined two different forest environments affected by contrasting wildfires in terms of severity: an eucalypt forest in Australia, which experienced an extremely severe wildfire, and a Mediterranean pine forest in Italy, which burned to moderate severity. We fractionated the ash/charcoal layers collected on the ground into four size fractions (>2, 2–1, 1–0.5, <0.5 mm) and analysed them for mineral ash content, elemental composition, chemical structure (by IR spectroscopy), fuel source and charcoal reflectance (by reflected-light microscopy), and chemical/thermal recalcitrance (by chemical and thermal oxidation). At both sites, the finest fraction (<0.5 mm) had, by far, the greatest mass. The C concentration and C/N ratio decreased with decreasing size fraction, while pH and the mineral ash content followed the opposite trend. The coarser fractions showed higher contribution of amorphous carbon and stronger recalcitrance. We also observed that certain fuel types were preferentially represented by particular size fractions. We conclude that the differences between ash/charcoal size fractions were most likely primarily imposed by fuel source and secondarily by burning conditions. Size fractionation can therefore serve as a valuable tool to characterise the forest wildfire combustion products, as each fraction displays a narrower range of properties than the whole sample. We propose the mineral ash content of the fractions as criterion for selecting the appropriate number of fractions to analyse. [less ▲]Detailed reference viewed: 11 (2 ULg) Microfossils from the late Mesoproterozoic – early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern AfricaBeghin, Jérémie ; Storme, Jean-Yves; Blanpied, Christian et alin Precambrian Research (2017), 291Detailed reference viewed: 26 (5 ULg) Use of cis-atracurium to maintain moderate neuromuscular blockade in experimental pigsTutunaru, Alexandru-Cosmin ; Dupont, Julien ; Serteyn, Didier et alin Veterinary Anaesthesia & Analgesia (2017)Detailed reference viewed: 10 (0 ULg) Impact of tillage on greenhouse gas emissions by an agricultural crop and dynamics of N2O fluxes: Insights from automated closed chamber measurementsLognoul, Margaux ; Theodorakopoulos, Nicolas ; Hiel, Marie-Pierre et alin Soil & Tillage Research (2017), 167Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O ... [more ▼]Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O fluxes. Gas measurements were performed from June to October 2015 in a Belgian maize crop, with homemade automated closed chambers, allowing continuous measurement at a high temporal resolution. After 7 years of treatment, CO2 and N2O average emissions were significantly larger in the RT parcel than in the CT parcel. This observation was attributed to the effect of tillage on the distribution of crop residues within the soil profile, leading to higher soil organic C and total N contents and a greater microbial biomass in the upper layer in RT. A single N2O emission peak triggered by a sudden increase of water- filled pore space (WFPS) was observed in the beginning of the measuring campaign. The absence of large emission afterwards was most likely due to a decreasing availability of N as crop grew. N2O background fluxes showed to be significantly correlated to CO2 fluxes but not to WFPS, while the influence of soil temperature remained unclear. Our results question the suitability of reduced tillage as a “climate-smart” practice and suggest that more experiments be conducted on conservation practices and their potent negative effect on environment. [less ▲]Detailed reference viewed: 114 (41 ULg) Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO)Cianferotti, Luisella; Bertoldo, Francesco; Bischoff-Ferrari, Heike et alin Endocrine (2017), 56(2), 245-61Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided ... [more ▼]Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. Purpose and Methods Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. Results and conclusions Robust mechanistic evidence is available from in vitro studies and in vivo animal studies, usually employing cholecalciferol, calcidiol or calcitriol in pharmacologic rather than physiologic doses. Although many cross-sectional and prospective association studies in humans have shown that low 25-hydroxyvitamin D levels (i.e., <50 nmol/L) are consistently associated with chronic diseases, further strengthened by a dose-response relationship, several meta-analyses of clinical trials have shown contradictory results. Overall, large randomized controlled trials with sufficient doses of vitamin D are missing, and available small to moderate-size trials often included people with baseline levels of serum 25-hydroxyvitamin D levels >50 nmol/L, did not simultaneously assess multiple outcomes, and did not report overall safety (e.g., falls). Thus, no recommendations can be made to date for the use of vitamin D supplementation in general, parental compounds, or non-hypercalcemic vitamin D analogs in the prevention and treatment of extra-skeletal chronic diseases. Moreover, attainment of serum 25-hydroxyvitamin D levels well above the threshold desired for bone health cannot be recommended based on current evidence, since safety has yet to be confirmed. Finally, the promising findings from mechanistic studies, large cohort studies, and small clinical trials obtained for autoimmune diseases (including type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus), cardiovascular disorders, and overall reduction in mortality require further confirmation. [less ▲]Detailed reference viewed: 15 (6 ULg) IgG4-related membranous glomerulonephritis and generalized lymphadenopathy without pancreatitis: a case reportHUART, Justine ; GROSCH, Stéphanie ; BOVY, Christophe et alin BMC Nephrology (2017), 18Abstract Background: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney ... [more ▼]Abstract Background: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney involvement is quite peculiar and has only been described a few times recently. Renal biopsy showed a glomerular involvement with membranous glomerulonephritis in association with a tubulo-interstitial nephropathy. Moreover, the patient was not suffering from pancreatitis. Case presentation: The patient is a middle-aged man of Moroccan origin. He has developed recurrent episodes of diffuse lymphadenopathies, renal failure and nephrotic syndrome. Renal biopsies showed membranous glomerulonephritis. Discussion and conclusion: The diagnostic approach of this atypical presentation is discussed in this case report as well as diagnostic criteria, therapeutic strategies, biomarkers and pathophysiology of IgG4-related disease. IgG4-related membranous glomerulonephritis is a well-established cause of membranous glomerulonephritis. It must be sought after in every patient with a previous diagnosis of IgG4-related disease and in every patient with this histological finding on renal biopsy. Corticoids are still the first-line treatment of IgG4-related disease. New therapeutic strategies are needed to avoid glucocorticoids long term side-effects. Interestingly, the patient was prescribed cyclophosphamide in addition to glucocorticoids for an immune thrombocytopenia. This treatment had a very good impact on his IgG4-related disease. [less ▲]Detailed reference viewed: 25 (3 ULg) Primary hypertrophic osteoarthropathy due to a novel SLCO2A1 mutation masquerading as acromegalyMangupli, Ruth; Daly, Adrian ; Cuauro, Elvia et alin Endocrinology, Diabetes and Metabolism Case Reports (2017)Detailed reference viewed: 6 (0 ULg) Plantations et bornage : prérogatives d'un emphytéotePopa, Ruxandra in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2017), 3-4(2017), Detailed reference viewed: 28 (1 ULg) "La madone et la putain": Quand les stéréotypes de genres influencent la perception de la légalité des violences sexuelles et le traitement de la réaction sociale à l'égard des femmesGarcet, Serge in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1Les illégalités liées au traitement différentiel des genres reposent notamment sur la présence de stéréotypes sexistes. L’article illustre comment les attitudes subjectivement positives à l’égard des ... [more ▼]Les illégalités liées au traitement différentiel des genres reposent notamment sur la présence de stéréotypes sexistes. L’article illustre comment les attitudes subjectivement positives à l’égard des femmes que l’on peut qualifier de stéréotypes sexistes bienveillants influencent tant positivement que négativement la façon dont les femmes sont perçues par le système judiciaire. L’article souligne également au travers des représentations liées aux violences sexuelles l’impact des stéréotypes sexistes hostiles sur la perception de la légalité, de la légitimité perçue du passage à l’acte et du statut des victimes. [less ▲]Detailed reference viewed: 33 (15 ULg) Hypercalcemie par mutation inactivatrice du CYP24A1. Etude d'un cas et revue de la litterature.Seidowsky, Alexandre; Villain, Cedric; Vilaine, Eve et alin Néphrologie & Thérapeutique (2017)We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene ... [more ▼]We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene: c.443 T>C (p.Leu148Pro) and c.1187 G>A (p.Arg396Gln). 24-VITD hydroxylase is a key player in regulating the circulating calcitriol, its tissue concentration and its biological effects. Transmission is recessive. The estimated prevalence of stones in the affected subjects is estimated between 10 and 15%. The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D. Although there are currently no recommendations (French review) on this subject, this disease should be suspected in association with recurrent calcium stones with nephrocalcinosis, and a calcitriol-dependent hypercalcaemia with adapted low parathyroid hormone levels. Resistance to corticosteroid therapy distinguishes it from other calcitriol-dependent hypercalcemia. A ratio of 25-hydroxyvitamin D/24.25 hydroxyvitamin D>50, is in favor of hypercalcemia with vitamin D deficiency 24-hydroxylase. Genetic analysis of CYP24A1 should be performed at the second step. The current therapeutic management includes the restriction native vitamin D supplementation and the limitation of sun exposure. Biological monitoring will be based on serum calcium control and modulation of parathyroid hormone concentrations. [less ▲]Detailed reference viewed: 11 (1 ULg) Deposition of ZnO based thin films by atmospheric pressure spatial atomic layer deposition for application in solar cellsNguyen, Viet; Avelas Resende, João ; Jimenez et alin Journal of Renewable and Sustainable Energy (2017)Detailed reference viewed: 20 (4 ULg) D’une victime à l’autre: Posture ou (im)posture victimaire?Garcet, Serge in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1Detailed reference viewed: 26 (8 ULg) Out of the ground: two coexisting fossorial toad species differ in their emergence and movement patternsSzékely, Diana ; Cogalniceanu, Dan; Székely, Paul et alin Zoology (2017), 121Understanding the way species with similar niches can coexist is a challenge in ecology.The niche partitioning hypothesis has received much support, positing that species can exploit available resources ... [more ▼]Understanding the way species with similar niches can coexist is a challenge in ecology.The niche partitioning hypothesis has received much support, positing that species can exploit available resources in different ways. In the case of secretive species, behavioural mechanisms of partitioning are still poorly understood. This is especially true for fossorial frogs because individuals hide underground by day and are active only during the night. We investigated the nocturnal activity and tested the niche partitioning hypothesis in two syntopic fossorial spadefoot toads (Pelobates fuscus and P. syriacus) by examining interspecific variation in emergence from the soil. We employed a night vision recording system combined with video-tracking analyses in a replicated laboratory setting to quantify individual movement patterns, a procedure that has not been used until now to observe terrestrial amphibians. Most individuals appeared on the surface every night and returned to their original burrow (about 60% of the times), or dug a new one around morning. There was a large temporal overlap between the two species. However, P. syriacus was significantly more active than P. fuscus in terms of total distance covered and time spent moving, while P. fuscus individuals left their underground burrow more frequently than P. syriacus. Consequently, P. fuscus adopted more of a sit-and-wait behaviour compared to P. syriacus, and this could facilitate their coexistence. The use of night video-tracking technologies offered the advantage of individually tracking these secretive organisms during their nocturnal activity period and getting fine-grain data to understand their movement patterns. [less ▲]Detailed reference viewed: 58 (24 ULg) Siblings and the coming out process: a comparative case studyHaxhe, Stéphanie ; Cerezo, Alison; Bergfeld, Jeanette et alin Journal of Homosexuality (2017), 64Detailed reference viewed: 58 (9 ULg) Clinical usefulness of bone turnover marker concentrations in osteoporosis.Morris, H. A.; Eastell, R.; Jorgesen, N. R. et alin Clinica Chimica Acta (2017), 467Current evidence continues to support the potential for bone turnover markers (BTM) to provide clinically useful information particularly for monitoring the efficacy of osteoporosis treatment. Many of the ... [more ▼]Current evidence continues to support the potential for bone turnover markers (BTM) to provide clinically useful information particularly for monitoring the efficacy of osteoporosis treatment. Many of the limitations identified earlier remain, principally in regard to the relationship between BTM and incident fractures. Important data are now available on reference interval values for CTX and PINP across a range of geographic regions and for individual clinical assays. An apparent lack of comparability between current clinical assays for CTX has become evident indicating the possible limitations of combining such data for meta-analyses. Harmonization of units for reporting serum/plasma CTX (ng/L) and PINP (mug/L) is recommended. The development of international collaborations continues with an important initiative to combine BTM results from clinical trials in osteoporosis in a meta-analysis and an assay harmonization program are likely to be beneficial. It is possible that knowledge derived from clinical studies can further enhance fracture risk estimation tools with inclusion of BTM together with other independent risk factors. Further data of the relationships between the clinical assays for CTX and PINP as well as physiological and pre-analytical factors contributing to variability in BTM concentrations are required. [less ▲]Detailed reference viewed: 32 (13 ULg) étude sur l'intolérance à l'incertitude et ses biais cognitifs chez les parents d'un enfant en rémission d'un cancerVander Haegen, Marie ; Etienne, Anne-Marie ; Piette, Carolinein Revue Médicale de Liège (2017), 72Résumé : Les études en oncologie pédiatrique décrivent une relativement bonne qualité de vie chez les enfants survivants de cancer. À ce jour, peu d’études se sont intéressées aux parents d’un enfant ... [more ▼]Résumé : Les études en oncologie pédiatrique décrivent une relativement bonne qualité de vie chez les enfants survivants de cancer. À ce jour, peu d’études se sont intéressées aux parents d’un enfant survivant de cancer. Soixante-et-un parents sont recrutés dans les hôpitaux belges. Trois groupes de parents sont constitués : les parents dont l’enfant est à 4 ans de rémission (groupe 1), à 5 ans de rémission (groupe 2) et à 6 ans de rémission (groupe 3). Des échelles cliniques et une tâche de Stroop émotion sont administrées. Les parents (des 3 groupes) présentent une faible tolérance à l’incertitude, ont des inquiétudes excessives quant à l’évolution de la santé de leur enfant et souffrent de symptômes anxieux. Le Stroop émotion révèle un biais cognitif de l’attention en faveur des stimuli de nature menaçante. L’étude met en exergue l’importance de détecter les parents intolérants à l’incertitude lors du diagnostic d’annonce du cancer et leur suivi psychologique continu une fois les traitements terminés. [less ▲]Detailed reference viewed: 23 (4 ULg) The Case of the Decaying CadaverStefanuto, Pierre-Hugues ; Focant, Jean-François in The Analytical Scientist (2017), 51Detailed reference viewed: 13 (3 ULg) On the identification of paedomorphic and overwintering larval newts based on cloacal shape: review and guidelinesDenoël, Mathieu in Current Zoology (2017), 63(2), 165-173Paedomorphosis is an alternative process to metamorphosis in which adults retain larval traits at the adult stage. It is frequent in newts and salamanders, where larvae reach sexual maturity without ... [more ▼]Paedomorphosis is an alternative process to metamorphosis in which adults retain larval traits at the adult stage. It is frequent in newts and salamanders, where larvae reach sexual maturity without losing their gills. However, in some populations, larvae overwinter in water, while remaining immature. These alternative ontogenetic processes are of particular interest in various research fields, but have different causes and consequences, as only paedomorphosis allows metamorphosis to be bypassed before maturity. It is thus relevant to efficiently identify paedomorphs versus overwintering larvae. In this context, the aim of this paper was threefold: firstly, to perform a meta-analysis of the identification procedures carried out in the literature; secondly, to determine the effectiveness of body size to make inferences about adulthood by surveying natural newt populations of Lissotriton helveticus and Ichthyosaura alpestris, and thirdly, to propose easy guidelines for an accurate distinction between large larvae and paedomorphs based on an external sexual trait, which is essential for reproduction — the cloaca. More than half of the studies in the literature do not mention the diagnostic criteria used for determining adulthood. The criteria mentioned were the presence of mature gonads (10%), eggs laid (4%), courtship behaviour (10%), and external morphological sexual traits (39%) including the cloaca (24%). Body-size thresholds should not be used as a proxy for paedomorphosis, because overwintering larvae can reach a larger size than paedomorphs within the same populations. In contrast, diagnosis based on cloacal external morphology is recommended, as it can be processed by the rapid visual assessment of all caught specimens, thus providing straightforward data at the individual level for both sexes. [less ▲]Detailed reference viewed: 195 (59 ULg) Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related CarcinogenesisHerfs, Michael ; Soong, Thing R; Delvenne, Philippe et alin Viruses (2017), 9 (4)Detailed reference viewed: 11 (3 ULg) Discovery of a woman portrait behind La Violoniste by Kees Van Dongen through hyperspectral imagingHerens, Elodie ; Defeyt, Catherine ; Walter, Philippe et alin Heritage Science (2017), 5(14), Despite the fact that Kees Van Dongen was one of the most famous painter of the 20th century, only little information about his palette and his technique is available. To contribute to the ... [more ▼]Despite the fact that Kees Van Dongen was one of the most famous painter of the 20th century, only little information about his palette and his technique is available. To contribute to the characterization of Van Dongen's painting materials, La Violoniste, painted by the artist around 1923, has been analyzed by using three complementary techniques: macro X-ray fluorescence (MA-XRF), Raman spectroscopy and hyperspectral imaging. The elemental repartition given by MA-XRF and the results obtained thanks to Raman spectroscopy help us to complete the identification of pigments contained in La Violoniste (lead white, iron oxides, cadmium yellow, vermilion, Prussian blue, titanium white, ultramarine, a chromium pigment and carbon black) while the results obtained via hyperspectral imaging reveal a hidden woman portrait. Besides the fact that Kees Van Dongen was particularly renowned for his female portraits, this hidden composition presents obvious stylistic similarities with the well-known portraits produced by the artist during his Parisian stay (starting from 1899). Thanks to Raman spectroscopy, visual examination and MA-XRF, we show that the original background contains ultramarine, the hidden portrait's clothes are probably made of the same colour as the present violinist's dress and her carnation contains zinc, contrary to the violinist's flesh which is mainly made of lead white. [less ▲]Detailed reference viewed: 83 (22 ULg) Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.Lesage, Julien; Suarez-Carmona, Meggy; Neyrinck-Leglantier, Deborah et alin FASEB Journal (2017), 31(4), 1678-1688Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the ... [more ▼]Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the functional involvement of ZO-1 in CXCL8/IL-8 chemokine expression in lung and breast tumor cells. ZO-1 small interfering RNA and cDNA transfection experiments emphasized regulation of CXCL8/IL-8 expression via a cytonuclear pool of ZO-1. Luciferase reporter assays highlighted a 173-bp region of CXCL8/IL-8 promoter that responded to ZO-1. Moreover, by using mutated promoter constructs, we identified a NF-κB site as critical in this activation. Furthermore, NF-κB pathway signaling analysis revealed both IκBα and p65 phosphorylation in ZO-1-overexpressing cells, and subsequent p65 silencing validated its requirement for CXCL8/IL-8 induction. Investigation of the functional implication of this regulatory axis next showed the proangiogenic activity of ZO-1 in both ex vivo and in vivo angiogenesis assays. Finally, we found that non-small-cell lung carcinoma that presented a cytonuclear ZO-1 pattern was significantly more angiogenic that that without detectable cytonuclear ZO-1 expression. Taken together, our results demonstrate that ZO-1 regulates CXCL8/IL-8 expression via the NF-κB signaling pathway and its p65 subunit, which subsequently modulates the transcription of IL-8. We also provide evidence of a newly identified regulatory pathway that could promote angiogenesis. Thus, our results support the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect both the intrinsic invasive properties of tumor cells and the establishment of the protumoral microenvironment. [less ▲]Detailed reference viewed: 24 (4 ULg) Les retardateurs de flamme bromés : impact sur l'environnement et la santé des individus exposésDufour, Patrice ; Charlier, Corinne in Annales de Biologie Clinique (2017), 75(2), 146-157Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de ... [more ▼]Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de façon massive dans l’industrie du plastique. À l’instar d’autres composés organohalogénés, les retardateurs de flamme bromés sont très persistants dans l’environnement et capables de s’accumuler le long de la chaîne alimentaire. De nombreux auteurs ont mis en évidence leur présence dans notre environnement, chez différentes espèces animales mais également dans le sérum humain. Plus inquiétant encore, l’homme est exposé à ces polluants dès la grossesse et par la suite via le lait maternel. Cette exposition pourrait avoir des conséquences sur notre santé. De nombreuses études in vitro, in vivo ou épidémiologiques ont mis en lumière une influence néfaste des retardateurs de flamme bromés sur notre système endocrinien, principalement au niveau de la fonction thyroïdienne mais également de la reproduction, du neurodéveloppement chez l’enfant et du métabolisme avec un risque accru de développer un diabète. Si une certaine prise de conscience a déjà eu lieu au niveau des autorités et de certaines grandes entreprises, de nouvelles études sont nécessaires pour confirmer les tendances déjà dégagées, élucider les mécanismes sous-jacents et déterminer s’il existe des synergies avec d’autres polluants tels que par exemple les PCB. [less ▲]Detailed reference viewed: 19 (4 ULg) Etude comparative des profils de dissolution in vitro de quinine sulfate générique et princeps en utilisant la Chromatographie Liquide Haute PerformanceMbinze Kindenge, Jérémie ; Diallo, Tediane; Yemoa, Loconon et alin Médecine d'Afrique Noire (2017), 64Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses ... [more ▼]Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses médicaments génériques d’une part, et au fléau des médicaments de qualité inférieure d’autre part, il devient plus que nécessaire d’appuyer les données des tests physico-chimiques par celles de dissolution in vitro dont l’évaluation et la comparaison des cinétiques permettra de prédire le comportement in vivo du principe actif et par conséquent l’efficacité du médicament générique. L’objectif de la présente étude est de réaliser une étude comparative de la cinétique de dissolution d’un princeps et d’un générique à base de quinine comprimé 300 mg commercialisés à Kinshasa. Matériels et méthodes : L’étude a été réalisée en utilisant trois milieux de pH différents (1,2 - 4,5 - 6,8) tels que recommandés par l’Agence Européenne de Médicament et en se servant d’un appareil de dissolution, tandis que l’équipement de chromatographie liquide à haute performance couplée à un détecteur à barrette de diodes a été utilisé pour la quantification. La méthode statistique fit factor a été appliquée pour comparer les résultats de dosage de la quinine dans les trois milieux tout en ayant évalué le biais à différents temps de dissolution. Résultats : Les différents échantillons de médicaments générique et princeps ont été conformes quant à l’identification et au dosage de la quinine, par contre leurs cinétiques de dissolution étaient non similaires. Discussion : Ceci pourrait avoir une influence sur l’efficacité du produit générique et la sécurité des consommateurs, dénotant l’importance d’examiner les profils de dissolution des génériques avant toute autorisation de mise sur le marché plus particulièrement dans les pays en voie de développement. [less ▲]Detailed reference viewed: 82 (41 ULg) Déploiement de dispositifs numériques au sein de nouvelles formes d’organisation : de l’émergence à la stabilisationJemine, Grégory in Sociologies Pratiques (2017), 34(1), 49-59De plus en plus d’organisations du secteur des services s’équipent aujourd’hui de dispositifs numériques variés qui modifient les contextes et les contenus du travail. Ces outils sont présentés comme des ... [more ▼]De plus en plus d’organisations du secteur des services s’équipent aujourd’hui de dispositifs numériques variés qui modifient les contextes et les contenus du travail. Ces outils sont présentés comme des ingrédients indispensables des modes managériales actuelles qui permettraient à divers dispositifs organisationnels promouvant la flexibilité et la mobilité de s’incarner. La présente contribution propose une étude des ressorts de l’émergence et de la stabilisation de ces dispositifs numériques qui émergent dans le cours de transformations organisationnelles. Nous montrons comment, dans une compagnie d’assurances, les dispositifs numériques sont mobilisés pour répondre à une volonté de « modernisation » de l’organisation et d’optimisation de l’espace de travail. [less ▲]Detailed reference viewed: 22 (8 ULg) Ville de Liège, reprenez la main ! : politique architecturale de la ville de LiègeDe Visscher, Lisa in A+ : Architecture in Belgium (2017), 265Liège is more than an imposing train station. Some major urban developments and small interventions at the level of a neighborhood redesign the city. Several important actors intervene in the process of ... [more ▼]Liège is more than an imposing train station. Some major urban developments and small interventions at the level of a neighborhood redesign the city. Several important actors intervene in the process of mutation in Liege, which is why a thorough architectural policy of the City of Liège must make a difference. [less ▲]Detailed reference viewed: 12 (1 ULg) Interest of creatine supplementation insoccerMiny, Kevin ; Burrowes, J; Jidovtseff, Boris in Science & Sports (2017), 32(2), 61-72Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially ... [more ▼]Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially negative) effects of this supplementation on sport-specific skills and performance in soccer players. Furthermore, this article accordingly discussed the safest and most recommended protocols for the consumption of creatine by these athletes. News Studies have shown that creatine supplementation can have positive effects on sprint and vertical jump performances in soccer players. This supplementation may also enhance soccer players’ muscle strength and adaptation to a high-intensity training regimen. Besides, creatine may be able to enhance muscle glycogen (as well as phosphocreatine) storage, reduce oxidative stress, and improve muscular repair and hypertrophy. Interestingly, creatine supplementation does not seem to affect aerobic performance. Prospects and projects Soccer players could take creatine during pre-season training (3 to 5g/day) in order to help them endure a high-intensity training regimen and enhance their muscular strength and adaptation resulting from strength and/or resistance training. A lower dosage (less than 3g/day) might also be sufficient and beneficial during the season in case of fatigue, in order to sustain adequate levels of phosphocreatine and glycogen in the muscles. Occasional intakes (about 3g) before games and/or extenuating practices could also give a physical and mental boost to the players. Conclusion Most of the studies measured the effects of creatine on skills or physical performances in isolation from the true athletic demands of soccer match play. In conclusion, there is still a need for more research in order to determine whether creatine supplementation is ergogenic regarding the (aerobic) capacity to repeat (very) high-intensity actions, more particularly during competitive soccer. [less ▲]Detailed reference viewed: 52 (9 ULg) Une mata-analyse des degrés de certitude exprimés en motsLeclercq, Dieudonné in Evaluer : Journal International de Recherche en Education et Formation (2017), 2(3), 69-105Asking to students to add a confidence degree to each of their responses to a test is rather rare, and the large majority of those who practice that use verbal scales such as “weakly sure”, “sure” ... [more ▼]Asking to students to add a confidence degree to each of their responses to a test is rather rare, and the large majority of those who practice that use verbal scales such as “weakly sure”, “sure”, “strongly sure”, etc. instead of probabilities or percentages of chances. My hypothesis is that consists in introducing, from the beginning, an enormous random error of measurement since there exist large differences in the interpretation (the translation) into percentages of the word used in verbal scales. I demonstrated this in two experiences (Leclercq, 2016), one in context and one context free. A strong convergence appear in the results of the two experiences in terms of communicational fog produced by words in place of percentages (from 0% to 100%). Variation Ranges (VR) of translations of words into percentages have a modal value of 40% and standard deviations (SD) from 10% to 15%. Therefore my hypothesis is confirmed by these two experiences, but what does the specialized literature say? In a first part of the present article I have browsed many reviews and books with the purpose to find data that contribute to fight (and kill ?) this habit of using words instead of percentages to express confidence degrees. Therefore I have named my method a “mata” analysis (matar meaning “to kill” in Spanish), that is distinct from meta-analysis, as will be shown. In the second part of the article, I underline data that help approach what could be the optimal number of numerical degrees (and their exact values) not only in terms of students’ preferences, but mainly in terms of the reliability (measured but the repeatability criterion, i.e; stability in a short period of time) of the declared confidence. [less ▲]Detailed reference viewed: 28 (1 ULg) Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitisAbboud, Dayana ; Hanson, Julien in Drug Discovery Today (2017), 22(4), 702-7011Detailed reference viewed: 34 (7 ULg) L'image du mois: Perforation intestinale grêle sur corps étrangerMaquet, Justine ; BOULANGER, Yves-Gautier ; MILICEVIC, Mladen in Revue Médicale de Liège (2017), 72(4), 165-167Les perforations intestinales grêles sont rares et ont de multiples étiologies. Nous rapportons le cas d'un patient âgé de 52 ans présentant des douleurs chroniques en fosse iliaque gauche depuis plus de ... [more ▼]Les perforations intestinales grêles sont rares et ont de multiples étiologies. Nous rapportons le cas d'un patient âgé de 52 ans présentant des douleurs chroniques en fosse iliaque gauche depuis plus de 9 mois. L'imagerie par entéro-IRM et CT scanner a permis de mettre en évidence d'une manière rétrospective une perforation intestinale grêle couverte par un corps étranger. L'intérêt de cette observation est de montrer d'une part les signes indirects de la perforation grêle et d'autre part le caractère migrant du corps étranger. [less ▲]Detailed reference viewed: 17 (2 ULg) An investigation into the fraction of particle accelerators among colliding-wind binaries. Towards an extension of the catalogueDe Becker, Michaël ; Benaglia, Paula; Romero, Gustavo E. et alin Astronomy and Astrophysics (2017), 600Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact ... [more ▼]Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact with different fields (magnetic or radiation) in the colliding-wind region and produce non-thermal emission. In many cases, non-thermal synchrotron radiation might be observable and thus constitute an indicator of the existence of a relativistic particle population in these multiple systems. To date, the catalogue of PACWBs includes about 40 objects spread over many stellar types and evolutionary stages, with no clear trend pointing to privileged subclasses of objects likely to accelerate particles. This paper aims at discussing critically some criteria for selecting new candidates among massive binaries. The subsequent search for non-thermal radiation in these objects is expected to lead to new detections of particle accelerators. On the basis of this discussion, some broad ideas for observation strategies are formulated. At this stage of the investigation of PACWBs, there is no clear reason to consider particle acceleration in massive binaries as an anomaly or even as a rare phenomenon. We therefore consider that several PACWBs will be detected in the forthcoming years, essentially using sensitive radio interferometers which are capable of measuring synchrotron emission from colliding-wind binaries. Prospects for high-energy detections are also briefly addressed. [less ▲]Detailed reference viewed: 15 (2 ULg) Decrease in climatic conditions favouring floods in the south-east of Belgium over 1959-2010 using the regional climate model MARWyard, Coraline ; Scholzen, Chloé ; Fettweis, Xavier et alin International Journal of Climatology (2017), 37(5), 27822796The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and ... [more ▼]The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and about 50% of them are due to heavy rainfall events combined to an abrupt melting of the snowpack covering the Ardennes massif during winter. This study aims to determine whether trends in extreme hydroclimatic events generating floods can be detected over the last century in Belgium, where a global warming signal can be observed. Hydroclimatic conditions favourable to floods were reconstructed over 1959- 2010 using the regional climate model MAR (“Modèle Atmosphérique Régional”) forced by the ERA-Interim/ERA-40, the ERA-20C and the NCEP/NCAR-v1 reanalyses. Extreme run-off events, which could potentially generate floods, were detected using run-off caused by precipitation events and snowpack melting from the MAR model. In the validation process, the MAR-driven temperature, precipitation and snow depth were successfully compared to daily weather data over the period 2008-2014 for 20 stations in Belgium. MAR also showed its ability to detect up to 90% of the hydroclimatic conditions which effectively generated observed floods in the Ourthe River over the period 1974- 2010. Conditions favourable to floods in the Ourthe River catchment present a negative trend over the period 1959-2010 as a result of a decrease in snow accumulation and a shortening of the snow season. This trend is expected to accelerate in a warmer climate. However, regarding the impact of the extreme precipitation events evolution on conditions favouring floods, the signal is less clear since the trends depend on the reanalysis used to force the MAR model. [less ▲]Detailed reference viewed: 104 (44 ULg) Perspective and priorities for improvement of parathyroid hormone (PTH) measurement - A view from the IFCC Working Group for PTH.Sturgeon, Catharine M.; Sprague, Stuart; Almond, Alison et alin Clinica Chimica Acta (2017), 467Parathyroid hormone (PTH) measurement in serum or plasma is a necessary tool for the exploration of calcium/phosphate disorders, and is widely used as a surrogate marker to assess skeletal and mineral ... [more ▼]Parathyroid hormone (PTH) measurement in serum or plasma is a necessary tool for the exploration of calcium/phosphate disorders, and is widely used as a surrogate marker to assess skeletal and mineral disorders associated with chronic kidney disease (CKD), referred to as CKD-bone mineral disorders (CKD-MBD). CKD currently affects >10% of the adult population in the United States and represents a major health issue worldwide. Disturbances in mineral metabolism and fractures in CKD patients are associated with increased morbidity and mortality. Appropriate identification and management of CKD-MBD is therefore critical to improving clinical outcome. Recent increases in understanding of the complex pathophysiology of CKD, which involves calcium, phosphate and magnesium balance, and is also influenced by vitamin D status and fibroblast growth factor (FGF)-23 production, should facilitate such improvement. Development of evidence-based recommendations about how best to use PTH is limited by considerable method-related variation in results, of up to 5-fold, as well as by lack of clarity about which PTH metabolites these methods recognise. This makes it difficult to compare PTH results from different studies and to develop common reference intervals and/or decision levels for treatment. The implications of these method-related differences for current clinical practice are reviewed here. Work being undertaken by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) to improve the comparability of PTH measurements worldwide is also described. [less ▲]Detailed reference viewed: 24 (1 ULg) Usefulness of multi-breed models in genetic evaluation of direct and maternal calving ease in Holstein and Belgian Blue Walloon purebreds and crossbredsVanderick, Sylvie ; Gillon, Alain; Glorieux, Géry et alin Livestock Science (2017), 198The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and ... [more ▼]The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and crossbred animals. Variance components and derived genetic parameters for purebred BBB and HOL animals were estimated by using single-breed linear animal models. This analysis showed clear genetic differences between breeds. Estimates of direct and maternal heritabilities (± standard error) were 0.34 (±0.02) and 0.09 (±0.01) for BBB, respectively, but only 0.09 (±0.01) and 0.04 (±0.01) for HOL, respectively. Moreover, a significant negative genetic correlation between direct and maternal effects was obtained in both breeds: −0.46 (±0.04) for BBB and −0.29 (±0.11) for HOL. Variance components and derived genetic parameters for purebred BBB and HOL and crossbred BBB ×× HOL cattle were then estimated by using two multi-breed linear animal models: a multi-breed model based on a random regression test-day model (Model MBV), and a multi-breed model based on the random regression multi-breed model (Model MBSM). Both multi-breed models use different functions of breed proportions as random regressions, thereby enabling modelling different additive effects according to animal's breed composition. The main difference between these models is the way in which relationships between breeds are accounted for in the genetic (co)variance structure. Genetic parameters differed between single-breed and multi-breed analysis, but are similar to the literature. For BBB, estimates of direct and maternal heritabilities (±SE) were 0.45 (±0.07) and 0.08 (±0.01) by using Model MBV, and 0.45 (±0.08) and 0.09 (±0.02) for Model MBSM, respectively. For HOL, these estimates were 0.18 (±0.04) and 0.05 (±0.01) using Model MBV, and 0.16 (±0.04) and 0.05 (±0.01) for Model MBSM, respectively. Reliability gains (up to 25%) indicated that the use of crossbred data in the multi-breed models had a positive influence on the estimation of genetic merit of purebred animals. A slight re-ranking of purebred sires and maternal grandsires was observed between single-breed and multi-breed models. Moreover, both multi-breed models can be considered as quasi-equivalent models because they performed almost equally well with respect to MSE and correlations, for purebred and crossbred animals. [less ▲]Detailed reference viewed: 35 (10 ULg) Retour sur le délit collectifKéfer, Fabienne in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (16), 738-739La nature réglementaire des infractions de non-paiement de rémunération ne les empêche pas de former un délit collectifDetailed reference viewed: 25 (5 ULg) Baelo Claudia dans l'Antiquité tardive. L'occupation du secteur sud-est du forum entre les IIIe et VIe sièclesBrassous, Laurent; Deru, Xavier ; Rodríguez Gutiérrez, Oliva et alin Melanges de la Casa de Velazquez (2017), 47(1), 167-200Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon ... [more ▼]Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon et de réoccupation entre les IIIe et VIe s. Les structures découvertes ainsi que le nombreux mobilier qui leur était associé (monnaies, céramique, verre, métal, faune, etc.) fournissent un éclairage nouveau sur l’histoire et la nature de l’agglomération dans l’antiquité tardive, qui entre la fin du IVe s. et son abandon définitif au VIe s. ressemble moins à une ville qu’à un gros village. [less ▲]Detailed reference viewed: 53 (1 ULg)