Conclusion: A novel set of measures was tested to get a novel insight on the pattern of information transfer in a network of scalp electrodes in patients with disorders of consciousness. [less ▲]Detailed reference viewed: 29 (6 ULg) A 3400 year lacustrine paleoseismic record from the North Anatolian Fault, Turkey: Implications for bimodal recurrence behaviorAvsar, Ulas; Hubert, Aurelia ; De Batist, Marc et alin Geophysical Research Letters (2014), 41(2), 377-384High-resolution physical, geochemical, and geochronological analyses on the sedimentary sequence of Yeniçağa Lake, located in a fault-bounded basin along the North Anatolian Fault, reveal fingerprints of ... [more ▼]High-resolution physical, geochemical, and geochronological analyses on the sedimentary sequence of Yeniçağa Lake, located in a fault-bounded basin along the North Anatolian Fault, reveal fingerprints of paleoearthquakes. A robust sediment chronology, spanning the last 3400 years, is constructed by radiocarbon dating and time-stratigraphical correlation with the precisely dated Sofular Cave speleothem record. Yeniçağa sedimentary sequence contains 11 seismically induced event deposits characterized by siliciclastic-enriched intervals. Some of the event deposits are also associated with implications of sudden lake deepening, which may be related to coseismic subsidence. The paleoearthquake series having an average recurrence interval of ca. 260 years are interrupted by two possible seismic gaps of ca. 420 and 540 years. [less ▲]Detailed reference viewed: 27 (12 ULg) A vibrotactile P300-based BCI for consciousness detection and communicationLugo, Zulay; Rodriguez, Javi; Lechner, Alexander et alin Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)Brain–computer interface (BCI) has been used for many years for communication in severely disabled patients. BCI based on electrophysiological signals has enabled communication, using auditory or visual ... [more ▼]Brain–computer interface (BCI) has been used for many years for communication in severely disabled patients. BCI based on electrophysiological signals has enabled communication, using auditory or visual stimuli to elicit event-related potentials (ERPs). The aim of this study was to determine whether patients with locked-in syndrome (LIS) could elicit a P300 wave, using a vibrotactile oddball paradigm for establishing somatosensory BCI-based communication. Six chronic LIS patients performed 2electroencephalography (EEG)-based vibrotactile P300 oddball tasks. After a simple mental counting task of the target stimuli, participants were instructed to answer 5 questions by counting the vibration on either the right wrist for “yes” or the left wrist for “no.” All participants were able to elicit a P300 wave using the vibrotactile oddball paradigm BCI task. In the counting task, 4 patients got accuracies of 100% (average above chance). In the communication task, one patient achieved 100% accuracy (average above chance). We have shown the feasibility of eliciting a P300 response using vibrotactile stimulation in patients with LIS. The present study provides evidence that this approach can be used for EEG-based BCI communications in this patient group. This is the first study to prove the feasibility of a BCI based on somatosensory (vibratory) stimulation in a group of braininjured patients. Furthermore, this approach could be used for the detection of consciousness in non-communicating patients due to severe brain injuries. [less ▲]Detailed reference viewed: 20 (4 ULg) A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in LivestockKumar Kadri, Naveen; Sahana, Goutam; Charlier, Carole et alin PLoS Genetics (2014), 10(1), 1004049In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has ... [more ▼]In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has concomitantly severely declined. It is generally assumed that this reduction is primarily due to the negative energy balance of high-producing cows at the peak of lactation. We herein describe the fine-mapping of a major fertility QTL in Nordic Red cattle, and identify a 660-kb deletion encompassing four genes as the causative variant. We show that the deletion is a recessive embryonically lethal mutation. This probably results from the loss of RNASEH2B, which is known to cause embryonic death in mice. Despite its dramatic effect on fertility, 13%, 23% and 32% of the animals carry the deletion in Danish, Swedish and Finnish Red Cattle, respectively. To explain this, we searched for favorable effects on other traits and found that the deletion has strong positive effects on milk yield. This study demonstrates that embryonic lethal mutations account for a non-negligible fraction of the decline in fertility of domestic cattle, and that associated positive effects on milk yield may account for part of the negative genetic correlation. Our study adds to the evidence that structural variants contribute to animal phenotypic variation, and that balancing selection might be more common in livestock species than previously appreciated. [less ▲]Detailed reference viewed: 16 (3 ULg) Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteriaWybo, Ingrid; Van den Bossche; Soetens, Oriane et alin Journal of Antimicrobial Chemotherapy (2014), 69Objectives: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre ... [more ▼]Objectives: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre studies. Methods: Four hundred and three strict anaerobic clinical isolates were prospectively collected from February 2011 to April 2012 in eight Belgian university hospitals. MICs were determined by one central laboratory for 11 antimicro- bial agents using Etest methodology. Results: According to EUCAST breakpoints, .90% of isolates were susceptible to amoxicillin/clavulanate (94%), piperacillin/tazobactam (91%), meropenem (96%), metronidazole (92%) and chloramphenicol (98%), but only 70% and 40% to clindamycin and penicillin, respectively. At CLSI recommended breakpoints, only 71% were sus- ceptible to moxifloxacin and 79% to cefoxitin. MIC50/MIC90 values for linezolid and for tigecycline were 1/4 and 0.5/ 4 mg/L, respectively. When compared with survey data from 2004, no major differences in susceptibility profiles were noticed. However, the susceptibility of Prevotella spp. and other Gram-negative bacilli to clindamycin decreased from 91% in 1993 – 94 and 82% in 2004 to 69% in this survey. Furthermore, the susceptibility of clostridia to moxifloxacin decreased from 88% in 2004 to 66% in 2011 – 12 and that of fusobacteria from 90% to 71%. Conclusions: Compared with previous surveys, little evolution was seen in susceptibility, except a decline in activity of clindamycin against Prevotella spp. and other Gram-negative bacteria, and of moxifloxacin against clostridia. Since resistance was detected to all antibiotics, susceptibility testing of anaerobic isolates is indicated in severe infections to confirm appropriateness of antimicrobial therapy. [less ▲]Detailed reference viewed: 10 (1 ULg) Automated analysis of background EEG and reactivity during therapeutic hypothermia in comatose patients after cardiac arrestNoirhomme, Quentin ; Lehembre, Rémy; Lugo, Zulay et alin Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)Visual analysis of electroencephalography (EEG) background and reactivity during therapeutic hypothermia provides important outcome information, but is time-consuming and not always consistent between ... [more ▼]Visual analysis of electroencephalography (EEG) background and reactivity during therapeutic hypothermia provides important outcome information, but is time-consuming and not always consistent between reviewers. Automated EEG analysis may help quantify the brain damage. Forty-six comatose patients in therapeutic hypothermia, after cardiac arrest, were included in the study. EEG background was quantified with burst-suppression ratio (BSR) and approximate entropy, both used to monitor anesthesia. Reactivity was detected through change in the power spectrum of signal before and after stimulation. Automatic results obtained almost perfect agreement (discontinuity) to substantial agreement (background reactivity) with a visual score from EEG-certified neurologists. Burst-suppression ratio was more suited to distinguish continuous EEG background from burst-suppression than approximate entropy in this specific population. Automatic EEG background and reactivity measures were significantly related to good and poor outcome. We conclude that quantitative EEG measurements can provide promising information regarding current state of the patient and clinical outcome, but further work is needed before routine application in a clinical setting. [less ▲]Detailed reference viewed: 32 (13 ULg) Robust method optimization strategy – a useful tool for method transfer: the case of SFCDispas, Amandine ; Lebrun, Pierre ; Andri, Bertyl et alin Journal of Pharmaceutical & Biomedical Analysis (2014), 88The concept of Quality by Design (QbD) is now well established in pharmaceutical industry and should be applied to the development of any analytical methods. In this context, the key concept of Design ... [more ▼]The concept of Quality by Design (QbD) is now well established in pharmaceutical industry and should be applied to the development of any analytical methods. In this context, the key concept of Design Space (DS) was introduced in the field of analytical method optimization. In chromatographic words, the DS is the space of chromatographic conditions that will ensure the quality of peaks separation, thus DS is a zone of robustness. In the present study, the interest of robust method optimization strategy was investigated in the context of direct method transfer from sending to receiving laboratory. The benefit of this approach is to speed up the method life cycle by performing only one quantitative validation step in the final environment of method use. A Supercritical Fluid Chromatography (SFC) method previously developed was used as a case study in this work. Moreover, the interest of geometric transfer was investigated simultaneously in order to stress a little bit more the transfer exercise and, by the way, emphasize the additional benefit of DS strategy in this particular context. Three successful transfers were performed on two column geometries. In order to compare original and transferred methods, the observed relative retention times (RT) were modelled as a function of the predicted relative RT and of the method type (original or transferred). The observed relative RT of the original and transferred methods are not statistically different and thus the method transfer is successfully achieved thanks to the robust optimization strategy. Furthermore, the analytical method was improved considering analysis time (reduced five times) and peak capacity (increased three times). To conclude, the advantage of using a DS strategy implemented for the optimization and transfer of SFC method was successfully demonstrated in this work. [less ▲]Detailed reference viewed: 37 (13 ULg) Effects of limestone fillers on surface free energy and electrical conductivity of the interstitial solution of cement mixesCourard, Luc ; Michel, Frédéric ; Perkowicz, Sylwia et alin Cement and Concrete Composites (2014), 45Most of concrete formulations actually contain mineral additives that are used as an inert filler or supplementary cementitious material (as type II addition). These materials are generally used in order ... [more ▼]Most of concrete formulations actually contain mineral additives that are used as an inert filler or supplementary cementitious material (as type II addition). These materials are generally used in order to increase concrete performances both in its fresh and hardened states. The mineral additives usually improve the consistency and workability of fresh concrete and reduce the water demand for a required concrete slump because of an additional volume of fines. The way of action depends on the physical and chemical characteristics of fillers. The study of surface free energies and electric conductivities of interstitial solutions of cement mixes modified by blast furnace slags and limestone fillers contributes to a better knowledge of hardening and interaction process. [less ▲]Detailed reference viewed: 32 (4 ULg) Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography.Gosseries, Olivia ; Thibaut, Aurore ; Boly, Mélanie et alin Annales Françaises d'Anesthésie et de Réanimation (2014)Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of ... [more ▼]Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of awareness in severely brain-injured patients is challenging because it relies on behavioral assessments, which can be affected by motor, sensory and cognitive impairments of the patients. Other means of evaluation are needed to improve the accuracy of the diagnosis in this challenging population. We will here review the different altered states of consciousness occurring after severe brain damage, and explain the difficulties associated with behavioral assessment of consciousness. We will then describe a non-invasive technique, transcranial magnetic stimulation combined with high-density electroencephalography (TMS-EEG), which has allowed us to detect the presence or absence of consciousness in different physiological, pathological and pharmacological states. Some potential underlying mechanisms of the loss of consciousness will then be discussed. In conclusion, TMS-EEG is highly promising in identifying markers of consciousness at the individual level and might be of great value for clinicians in the assessment of consciousness. [less ▲]Detailed reference viewed: 12 (1 ULg) Analysis of PSII antenna size heterogeneity of Chlamydomonas reinhardtii during state transitionsde Marchin, Thomas ; Ghysels, Bart ; Nicolay, Samuel et alin Biochimica et Biophysica Acta-Bioenergetics (2014), 1837(1), 121-130PSII antenna size heterogeneity has been intensively studied in the past. Based on DCMU fluorescence rise kinetics, multiple types of photosystems with different properties were described. However, due to ... [more ▼]PSII antenna size heterogeneity has been intensively studied in the past. Based on DCMU fluorescence rise kinetics, multiple types of photosystems with different properties were described. However, due to the complexity of fluorescence signal analysis, multiple questions remain unanswered. The number of different types of PSII is still debated as well as their degree of connectivity. In Chlamydomonas reinhardtii we found that PSIIα possesses a high degree of connectivity and an antenna 2-3 times larger than PSIIβ, as described previously. We also found some connectivity for PSIIβ in contrast with the majority of previous studies. This is in agreement with biochemical studies which describe PSII mega-, super- and core- complexes in Chlamydomonas. In these studies, the smallest unit of PSII in vivo would be a dimer of two core complexes hence allowing connectivity. We discuss the possible relationships between PSIIα and PSIIβ and the PSII mega-, super- and core- complexes. We also showed that strain and medium dependent variations in the half-time of the fluorescence rise can be explained by variations in the proportions of PSIIα and PSIIβ. When analyzing the state transition process in vivo, we found that this process induces an inter-conversion of PSIIα and PSIIβ. During a transition from state 2 to state 1, DCMU fluorescence rise kinetics are satisfactorily fitted by considering two PSII populations with constant kinetic parameters. We discuss our findings about PSII heterogeneity during state transitions in relation with recent results on the remodeling of the pigment-protein PSII architecture during this process. [less ▲]Detailed reference viewed: 45 (15 ULg) A climate analysis tool for passive heating and cooling strategies in hot humid climate based on Typical Meteorological Year data setsNguyen, Anh Tuan ; Reiter, Sigrid in Energy & Buildings (2014), 68(Part C), 756-763Through a newly developed climate analysis tool, this paper examines the potential of improving thermal comfort under the climates of Vietnam thanks to passive strategies. A Building climatic chart for ... [more ▼]Through a newly developed climate analysis tool, this paper examines the potential of improving thermal comfort under the climates of Vietnam thanks to passive strategies. A Building climatic chart for Vietnamese was proposed based on Fanger’s theory [1] and the comfort zone of this chart was then extended by calculating the effects of passive heating and cooling strategies. Typical Meteorological Year weather data are used for extracting and graphically printing of hourly environmental parameters on the psychrometric chart and for climate analysis, subsequently. The limitation and the scope of this method are also specified. The climates of three climatic regions in Vietnam have been used as case studies using all year, seasonal and monthly analysis. The results show that natural ventilation is an effective cooling solution as thermal comfort improvement varies with the climatic zones, increasing from 24.8% in Hanoi, 22.1% in Danang to 32.0% in Hochiminh city. Meanwhile, passive solar heating is only effective under the climate of Hanoi. Direct evaporative cooling also shows great cooling potential for comfort improvement but probable elevated humidity is not expected. Total possible comfort in a year of each location indicates that further climate modification methods are inevitable to achieve comfort during extreme weather conditions, especially in Hanoi. [less ▲]Detailed reference viewed: 97 (19 ULg) Le droit pour le prévenu de comparaître personnellement devant les juridictions répressivesMichiels, Olivier in Revue de Droit Pénal et de Criminologie (2014), 1/2014(janvier), 113-119La note rappelle les règles belges relatives à la comparution du prévenu personne physique devant les juridictions répressives en les mettant en parallèle avec la jurisprudence de la Cour européenne des ... [more ▼]La note rappelle les règles belges relatives à la comparution du prévenu personne physique devant les juridictions répressives en les mettant en parallèle avec la jurisprudence de la Cour européenne des droits de l'homme. Elle s'attache ensuite à examiner la question de l'incapacité pour une partie d'être présente à son procès. [less ▲]Detailed reference viewed: 17 (1 ULg) Le canon littéraire au crible des PhysiologiesStienon, Valérie in Revue d'Histoire Littéraire de la France (2014), 1Gustave Lanson considérait les productions mineures comme le tissu conjonctif de l’histoire littéraire. Un tel point de vue peut rapidement faire apparaître les Physiologies parisiennes des années 1830 ... [more ▼]Gustave Lanson considérait les productions mineures comme le tissu conjonctif de l’histoire littéraire. Un tel point de vue peut rapidement faire apparaître les Physiologies parisiennes des années 1830-1845 comme le laboratoire de bien des esthétiques modernes, ce corpus étant d’autant plus inventif qu’il procède pour une grande part des poétiques d’écriture hybrides et expansives de la presse. Parce qu'elles sont enclines à traiter du personnel, des lieux et des pratiques littéraires à partir d'une fraction symboliquement réprouvée, sinon marginale, de la production littéraire, les Physiologies peuvent assumer tout à la fois une fonction de régulation et de révélation des processus de légitimation. L'article met en évidence ce double rôle d'élucidation et d'observation participante manifestée par ces textes. [less ▲]Detailed reference viewed: 10 (1 ULg) Enzymatic creatinine assays allowestimation of glomerular filtration rate in stages 1 and 2 chronic kidney disease using CKD-EPI equationKuster, Nils; Cristol, Jean-Paul; CAVALIER, Etienne et alin Clinica Chimica Acta (2014), 428The National Kidney Disease Education Program group demonstrated that MDRD equation is sensitive to creatinine measurement error, particularly at higher glomerular filtration rates. Thus, MDRD-based eGFR ... [more ▼]The National Kidney Disease Education Program group demonstrated that MDRD equation is sensitive to creatinine measurement error, particularly at higher glomerular filtration rates. Thus, MDRD-based eGFR above 60 mL/min/1.73 m2 should not be reported numerically. However, little is known about the impact of analytical error on CKD-EPI-based estimates. This study aimed at assessing the impact of analytical characteristics (bias and imprecision) of 12 enzymatic and 4 compensated Jaffe previously characterized creatinine assays on MDRD and CKD-EPI eGFR. In a simulation study, the impact of analytical error was assessed on a hospital population of 24 084 patients. Ability using each assay to correctly classify patients according to chronic kidney disease (CKD) stages was evaluated. For eGFR between 60 and 90 mL/min/1.73 m2, both equations were sensitive to analytical error. Compensated Jaffe assays displayed high bias in this range and led to poorer sensitivity/specificity for classification according to CKD stages than enzymatic assays. As compared to MDRD equation, CKD-EPI equation decreases impact of analytical error in creatinine measurement above 90 mL/min/1.73 m2. Compensated Jaffe creatinine assays lead to important errors in eGFR and should be avoided. Accurate enzymatic assays allow estimation of eGFR until 90 mL/min/1.73 m2 with MDRD and 120 mL/min/1.73 m2 with CKD-EPI equation. [less ▲]Detailed reference viewed: 16 (0 ULg) Contribution to the macrophytic typology of the Belgian reference watercoursesGaloux, Daniel; Chérot, Frédéric; Rosillon, Francis et alin International Journal of Water Sciences (2014)The objective of the study is to create a typology of macrophytes for the reference watercourses of the Meuse River catchment basin in Wallonia, as a step towards the implementation of the European Water ... [more ▼]The objective of the study is to create a typology of macrophytes for the reference watercourses of the Meuse River catchment basin in Wallonia, as a step towards the implementation of the European Water Framework Directive. The 50 sites studied are the object of a physicochemical and environmental characterisation followed by a floristic survey (phanerogams, mosses, liverworts, and macroalgae). Six clusters of watercourses with their characteristic species are highlighted by two-way clustering and indicator species. The abundance of phanerogams in some watercourses of the Arden region is not only linked to light intensity but also depends on the degree of slope and the nature of the geological substrate. [less ▲]Detailed reference viewed: 14 (4 ULg) Isolation of an amylolytic chrysophyte, Poterioochromonas sp. from the digestive tract of the termite R. santonensisTarayre, Cédric ; Bauwens, Julien ; Brasseur, Catherine et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(1), The aim of this work was the isolation and cultivation of amylolytic protists living in the digestive tract of the termite Reticulitermes santonensis (Feytaud). A chrysophyte identified as ... [more ▼]The aim of this work was the isolation and cultivation of amylolytic protists living in the digestive tract of the termite Reticulitermes santonensis (Feytaud). A chrysophyte identified as Poterioochromonas sp. was isolated in a special medium containing rice grains as a source of carbon and nitrogen. Then, the protist was grown in a medium containing starch as a carbon source, tryptone, and a phosphate buffer at different pH values (5, 6 and 7). Yeast extract was added or not. Ciprofloxacin was used to avoid the bacterial development. Other antibiotics were also tested but showed an inhibitive effect on the growth of Poterioochromonas sp. Yeast extract allowed reaching 1.9 (pH 5), 2.3 (pH 6) and 2.2 (pH 7) times higher final cell concentrations, and 2.8 (pH 5), 2.8 (pH 6) and 2.2 (pH 7) times higher biomass yields. The starch concentration did not decrease in the medium until 3 and 4 days of culture, with and without yeast extract, respectively. Eight days of culture were necessary for hydrolyzing the starch completely, with and without yeast extract. Maltose and maltotriose were detected in the culture media and were hydrolyzed progressively. Maximal maltose concentrations were 0.68, 0.66 and 0.51 g.l-1 in the medium containing yeast extract. Maltotriose concentrations were only 0.17, 0.14 and 0.12 g.l-1. Other glucose oligomers were also detected but in lower quantities. It was determined that the protist developed a weak amylase activity, particularly at a weakly acidic pH (5-6). Such a pH also allowed a better growth of the protist. A maximal amylase activity of 112 nkat.l-1 was measured with yeast extract at pH 5. No other enzymatic activity (protease, cellulase or xylanase) was detected except amylase. The degradation products of starch which were obtained by enzymatic hydrolysis allow the identification of α-amylase, amyloglucosidase and possibly β-amylase activities. [less ▲]Detailed reference viewed: 25 (11 ULg) Micro-CT based characterisation of the effect of surface modification on the morphology and roughness of selective laser melted Ti6Al4V open porous structuresPyka, G.; Kerckhofs, Greet ; Van Bael, S. et alin Materials Characterization (2014), 87Detailed reference viewed: 1 (1 ULg) Geometrically exact beam finite element formulated on the special Euclidean group SE(3)Sonneville, Valentin ; Cardona, Alberto; Bruls, Olivier in Computer Methods in Applied Mechanics & Engineering (2014), 268This paper describes a dynamic formulation of a straight beam finite element in the setting of the special Euclidean group SE(3). First, the static and dynamic equilibrium equations are derived in this ... [more ▼]This paper describes a dynamic formulation of a straight beam finite element in the setting of the special Euclidean group SE(3). First, the static and dynamic equilibrium equations are derived in this framework from variational principles. Then, a non-linear interpolation formula using the exponential map is introduced. It is shown that this framework leads to a natural coupling in the interpolation of the position and rotation variables. Next, the discretized internal and inertia forces are developed. The semi-discrete equations of motion take the form of a second-order ordinary differential equation on a Lie group, which is solved using a Lie group time integration scheme. It is remarkable that no parameterization of the nodal variables needs to be introduced and that the proposed Lie group framework leads to a compact and easy-to-implement formulation. Some important numerical and theoretical aspects leading to a computationally efficient strategy are highlighted and discussed. For instance, the formulation leads to invariant tangent stiffness and mass matrices under rigid body motions and a locking free element. The proposed formulation is successfully tested in several numerical static and dynamic examples. [less ▲]Detailed reference viewed: 24 (9 ULg) Entre permis forestier et permis minier, la diff icile émergence des forêts communautaires au GabonMorin, Amélie; Meunier, Quentin; Moumbogou et alin Parcs et Réserves (2014), 68(4), 16-22A l’heure de l’attribution des premières forêts communautaires au Gabon, de multiples questions surgissent et attendent de manière urgente une réponse de la part de l’Etat. Le présent article se penche ... [more ▼]A l’heure de l’attribution des premières forêts communautaires au Gabon, de multiples questions surgissent et attendent de manière urgente une réponse de la part de l’Etat. Le présent article se penche sur l’une d’entre elles, à savoir la superposition des permis d’exploitation (minier, forestier) avec l’espace utilisé traditionnellement par les communautés locales et candidates à l’obtention d’une forêt communautaire. Quelques situations rencontrées sur le terrain sont présentées et discutées. Il est urgent qu’un réel aménagement du territoire voie le jour au Gabon, qui détermine la place de chaque activité, hiérarchise l’affectation de l’espace et détermine le cas échéant les conditions de « cohabitation » de plusieurs permis. [less ▲]Detailed reference viewed: 64 (12 ULg) The Silence of the LabsHendrickx, Kim in LIMN (2014), (4), Is sugar a choice? Kim hendrickx explores how a sugar museum puts life and health in perspectiveDetailed reference viewed: 14 (1 ULg) Vascular Endothelial Growth Factor-111 (VEGF-111) and tendon healing: preliminary results in a rat model of tendon injuryKaux, Jean-François ; Janssen, Lauriane ; Drion, Pierre et alin Muscle, Ligaments and Tendons Journal (2014), 1(5), 25-28Tendon lesions are among the most frequent musculoskeletal pathologies. Vascular endothelial growth factor (VEGF) is known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis ... [more ▼]Tendon lesions are among the most frequent musculoskeletal pathologies. Vascular endothelial growth factor (VEGF) is known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified. This study aimed at evaluating whether VEGF-111 could have a therapeutic interest in tendon pathologies. Surgical section of one Achilles tendon of rats was performed before a local injection of either saline or VEGF-111. After 5, 15 and 30 days, the Achilles tendons of 10 rats of both groups were sampled and submitted to a biomechanical tensile test. The force necessary to induce tendon rupture was greater for tendons of the VEGF-111 group (p<0.05) while the section areas of the tendons were similar. The mechanical stress was similar at 5 and 15 days in the both groups but was improved for the VEGF-111 group at day 30 (p <0.001). No difference was observed in the mRNA expression of collagen III, tenomodulin and MMP-9. In conclusion, we observed that a local injection of VEGF-111 improves the early phases of the healing process of rat tendons after a surgical section. Further confirmatory experimentations are needed to consolidate our results. [less ▲]Detailed reference viewed: 15 (0 ULg) Subjective Evaluation of the Audiovisual Spatial Congruence in the Case of Stereoscopic-3D Video and Wave Field SynthesisAndré, Cédric ; Corteel, Etienne; Embrechts, Jean-Jacques et alin International Journal of Human-Computer Studies (2014), 72(1), 23-32While 3D cinema is becoming increasingly established, little effort has focused on the general problem of producing a 3D sound scene spatially coherent with the visual content of a stereoscopic-3D (s-3D ... [more ▼]While 3D cinema is becoming increasingly established, little effort has focused on the general problem of producing a 3D sound scene spatially coherent with the visual content of a stereoscopic-3D (s-3D) movie. The perceptual relevance of such spatial audiovisual coherence is of significant interest. In this paper, a subjective experiment is carried out where an angular error between an s-3D video and a spatially accurate sound reproduced through Wave Field Synthesis (WFS) is simulated. The psychometric curve is measured with the method of constant stimuli, and the threshold for bimodal integration is estimated. The impact of the presence of background noise is also investigated. A comparison is made between the case without any background noise and the case with an SNR of 4 dB(A). Estimates of the thresholds and the slopes, as well as their confidence intervals, are obtained for each level of background noise. When background noise was present, the point of subjective equality (PSE) was higher (19.4° instead of 18.3°) and the slope was steeper (-0.077 instead of -0.062 per degree). Because of the overlap between the confidence intervals, however, it was not possible to statistically differentiate between the two levels of noise. The implications for the sound reproduction in a cinema theater are discussed. [less ▲]Detailed reference viewed: 81 (16 ULg) Water soluble exo-polysaccharide from Syncephalastrum racemosum, a strong inducer of plant defence reactionsValepyn, Emmanuel ; Cabrera, Juan-Carlos; Richel, Aurore et alin Carbohydrate Polymers (2014), 101This study examines the production, characterization and bioactivity on plant cell cultured in vitro of exopolysaccharides (EPS) from Syncephalastrum racemosum CBS 443.59. Firstly, the influence of the ... [more ▼]This study examines the production, characterization and bioactivity on plant cell cultured in vitro of exopolysaccharides (EPS) from Syncephalastrum racemosum CBS 443.59. Firstly, the influence of the fungus culture condition in shake flasks (pH, temperature and different carbon and nitrogen sources) on EPS and biomass production were evaluated. In order to enhance EPS production, a new protocol based on two-stage pH fermentation in a 3 L stirred fermentor was developed. Under this condition, EPS production increased by 3.55 times, compared to a constant pH process, reaching a maximal EPS concentration of 2.62 g/L. Structurally, the EPS contains a polyglucuronic acid backbone, linked essentially with mannose and fucose units and some galactose and glucose units. The bioactivity of EPS as inducer of defence reactions in plant suspension-cultured cells was also studied. Our results show, for first time, that EPS from S. racemosum CBS 443.59 induces, depending on the concentration, PAL activation and H2O2 synthesis in Arabidospsis thaliana cell suspensions. [less ▲]Detailed reference viewed: 21 (6 ULg) Modelling the Holocene migrational dynamics of Fagus sylvatica L. and Picea abies (L.) H. KarstLehsten, Lehsten; Dullinger, Stefan; Hülber, Karl et alin Global Ecology and Biogeography (2014)Aim: Vegetation dynamics and the competitive interactions involved are assumed to restrict the ability of species to migrate. But in most migration modelling approaches disturbance-driven succession and ... [more ▼]Aim: Vegetation dynamics and the competitive interactions involved are assumed to restrict the ability of species to migrate. But in most migration modelling approaches disturbance-driven succession and competition processes are reduced to simple assumptions or are even missing. The aim of this study was to test a combination of a migration model and a dynamic vegetation model to estimate the migration of tree species controlled by climate, environment and local species dynamics such as succession and competition. Location: Europe. Methods: To estimate the effect of vegetation dynamics on the migration of European beech and Norway spruce, we developed a post-process migration tool (LPJ-CATS). This tool integrates outputs of the migration model CATS and the dynamic vegetation model LPJ-GUESS. The model LPJ-CATS relies on a linear dependency between the dispersal kernel and migration rate and is based on the assumption that competition reduces fecundity. Results: Simulating potential migration rates with the CATS model, which does not account for competition and disturbance, resulted in mean Holocene migra- tion rates of 435 ± 55 and 330 ± 95 m year−1 for the two species Picea abies and Fagus sylvatica, respectively. With LPJ-CATS, these mean migration rates were reduced to 250 ± 75 and 170 ± 60 m year−1 for spruce and beech, respectively. Moreover, LPJ-CATS simulated migration pathways of these two species that gen- erally comply well with those documented in the palaeo-records. Main conclusions: Our ‘hybrid’ modelling approach allowed for the simulation of generally realistic Holocene migration rates and pathways of the two study species on a continental scale. It suggests that competition can considerably modify spread rates, but also the magnitude of its effect depends on how close climate conditions are to the niche requirements of a particular species. [less ▲]Detailed reference viewed: 13 (2 ULg) Détermination des propriétés de couches dans le béton à l'aide d'un géoradar commercial à hautes fréquences: approche pic-à-pic et analyse fréquentielle du coefficient de réflexionVan der Wielen, Audrey ; Nguyen, Frédéric ; Courard, Luc in Annales du Bâtiment et des Travaux Publics (2014)The Ground Penetrating Radar (GPR) is an efficient tool for the non-destructive inspection of concrete structures. It is widely used for the detection of rebars or humid zones or for evaluating the ... [more ▼]The Ground Penetrating Radar (GPR) is an efficient tool for the non-destructive inspection of concrete structures. It is widely used for the detection of rebars or humid zones or for evaluating the thickness of elements. But when an element contains a thin layer, the radar waves are submitted to multiple reflections on the interfaces and the layer appears in the radargram as a single reflection, whose detailed analysis can allow determining the thickness and the permittivity of the thin layer. Two approaches were considered in this paper. In the first one, the analysis is based on the peak-to-peak reflection amplitude. The second approach uses a frequency analysis of the reflection coefficient, whose amplitude and phase can then be calculated for several frequencies. With this method, the thickness and permittivity of the layer can in theory be simultaneously determined. Both methods were numerically validated through finite difference simulations and experimentally tested on concrete samples containing an air layer of variable thickness. We showed that the frequency analysis allowed to reach a higher precision in the parameters estimation for a limited additional computing cost. The method efficiency depends on the conditions and is optimal for layers with a high permittivity presenting a large contrast with the matrix. [less ▲]Detailed reference viewed: 8 (1 ULg) A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle.Sartelet, Arnaud ; Stauber, Tobias; Coppieters, Wouter et alin Disease Models & Mechanisms (2014), 7Chloride/proton exchange by the lysosomal anion transporter ClC-7/Ostm1 is of pivotal importance for the physiology of lysosomes and bone resorption. Mice lacking either ClC-7 or Ostm1 develop a lysosomal ... [more ▼]Chloride/proton exchange by the lysosomal anion transporter ClC-7/Ostm1 is of pivotal importance for the physiology of lysosomes and bone resorption. Mice lacking either ClC-7 or Ostm1 develop a lysosomal storage disease and mutations in either protein have been found to underlie osteopetrosis in mice and humans. Some human disease-causing CLCN7 mutations accelerate the usually slow voltage-dependent gating of ClC-7/Ostm1. However, it has remained unclear whether the fastened kinetics is indeed causative for the disease. Here we identified and characterized a new deleterious ClC-7 mutation in Belgian Blue Cattle with a severe symptomatology including peri-natal lethality and in most cases gingival hamartomas. By autozygosity mapping and genome-wide sequencing we found a handful of candidate variants, including a cluster of three private SNPs causing the substitution of a conserved tyrosine in the CBS2 domain of ClC-7 by glutamine. The case for ClC-7 was strengthened by subsequent examination of affected calves that revealed severe osteopetrosis. The Y750Q mutation largely preserved the lysosomal localization and assembly of ClC-7/Ostm1, but drastically accelerated its activation by membrane depolarization. These data provide first evidence that accelerated ClC-7/Ostm1 gating per se is deleterious, highlighting a physiological importance of the slow voltage-activation of ClC-7/Ostm1 in lysosomal function and bone resorption. [less ▲]Detailed reference viewed: 31 (2 ULg) Quantifying cortical EEG responses to TMS in (un)consciousnessSarasso, S; Rosanova, M; Casali, A.G et alin Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)We normally assess another individual's level of consciousness based on her or his ability to interact with the surrounding environment and communicate. Usually, if we observe purposeful behavior ... [more ▼]We normally assess another individual's level of consciousness based on her or his ability to interact with the surrounding environment and communicate. Usually, if we observe purposeful behavior, appropriate responses to sensory inputs, and, above all, appropriate answers to questions, we can be reasonably sure that the person is conscious. However, we know that consciousness can be entirely within the brain, even in the absence of any interaction with the external world; this happens almost every night, while we dream. Yet, to this day, we lack an objective, dependable measure of the level of consciousness that is independent of processing sensory inputs and producing appropriate motor outputs. Theoretically, consciousness is thought to require the joint presence of functional integration and functional differentiation, otherwise defined as brain complexity. Here we review a series of recent studies in which Transcranial Magnetic Stimulation combined with electroencephalography (TMS/EEG) has been employed to quantify brain complexity in wakefulness and during physiological (sleep), pharmacological (anesthesia) and pathological (brain injury) loss of consciousness. These studies invariably show that the complexity of the cortical response to TMS collapses when consciousness is lost during deep sleep, anesthesia and vegetative state following severe brain injury, while it recovers when consciousness resurges in wakefulness, during dreaming, in the minimally conscious state or locked-in syndrome. The present paper will also focus on how this approach may contribute to unveiling the pathophysiology of disorders of consciousness affecting brain-injured patients. Finally, we will underline some crucial methodological aspects concerning TMS/EEG measurements of brain complexity. [less ▲]Detailed reference viewed: 6 (0 ULg) Open flux in Saturn's magnetosphereBadman, Sarah; Jackman, Caitriuna; Nichols, Jonathan et alin Icarus (2014), 231Detailed reference viewed: 5 (0 ULg) Toward genomic prediction from whole-genome sequence data: impact of sequencing design on genotype imputation and accuracy of predictions.Druet, Tom ; Macleod, I. M.; Hayes, B. J.in Heredity (2014), 112(1), 39-47Genomic prediction from whole-genome sequence data is attractive, as the accuracy of genomic prediction is no longer bounded by extent of linkage disequilibrium between DNA markers and causal mutations ... [more ▼]Genomic prediction from whole-genome sequence data is attractive, as the accuracy of genomic prediction is no longer bounded by extent of linkage disequilibrium between DNA markers and causal mutations affecting the trait, given the causal mutations are in the data set. A cost-effective strategy could be to sequence a small proportion of the population, and impute sequence data to the rest of the reference population. Here, we describe strategies for selecting individuals for sequencing, based on either pedigree relationships or haplotype diversity. Performance of these strategies (number of variants detected and accuracy of imputation) were evaluated in sequence data simulated through a real Belgian Blue cattle pedigree. A strategy (AHAP), which selected a subset of individuals for sequencing that maximized the number of unique haplotypes (from single-nucleotide polymorphism panel data) sequenced gave good performance across a range of variant minor allele frequencies. We then investigated the optimum number of individuals to sequence by fold coverage given a maximum total sequencing effort. At 600 total fold coverage (x 600), the optimum strategy was to sequence 75 individuals at eightfold coverage. Finally, we investigated the accuracy of genomic predictions that could be achieved. The advantage of using imputed sequence data compared with dense SNP array genotypes was highly dependent on the allele frequency spectrum of the causative mutations affecting the trait. When this followed a neutral distribution, the advantage of the imputed sequence data was small; however, when the causal mutations all had low minor allele frequencies, using the sequence data improved the accuracy of genomic prediction by up to 30%.Heredity advance online publication, 3 April 2013; doi:10.1038/hdy.2013.13. [less ▲]Detailed reference viewed: 24 (10 ULg) Biostratigraphic significance of brachiopods near the Devonian–Carboniferous boundaryMottequin, Bernard ; Brice, Denise; Legrand-Blain, Mariein Geological Magazine (2014), 151The biostratigraphic significance of selected uppermost Famennian (Upper Devonian) and lower Tournaisian (Mississippian) brachiopod genera, belonging to the orders Rhynchonellida (e.g. Araratella ... [more ▼]The biostratigraphic significance of selected uppermost Famennian (Upper Devonian) and lower Tournaisian (Mississippian) brachiopod genera, belonging to the orders Rhynchonellida (e.g. Araratella), Spiriferida (e.g. Sphenospira, Prospira), Spiriferinida (Syringothyris) and Productida (except Chonetidina), is discussed. Owing to the difficulties of identifying productidine and strophalosiidine genera, in contrast to rhynchonellides and spiriferides, the biostratigraphic potential of the former has generally been overlooked. Brachiopods flourished in neritic environments that were unfavourable for conodonts and ammonoids. In the absence of the latter traditional marker fossils, they are potentially important for locating the Devonian–Carboniferous boundary in shallow water depositional settings in conjunction with rugose corals and foraminifers. On a worldwide scale, further work is required to reach a better assessment of the aftermath of the Hangenberg biological Crisis on brachiopods, notably in revising the faunas from the classical areas of the Famennian and Tournaisian stages in Western Europe. [less ▲]Detailed reference viewed: 31 (13 ULg) Effect of misalignment on pull-off test results: numerical and experimental assessmentsCourard, Luc ; Bissonnette, Benoît; Garbacz, Andrzej et alin ACI Materials Journal (2014), 111The successful application of a concrete repair system is often evaluated through pull-off testing. For such in-situ quality control (QC) testing, the inherent risk of misalignment might affect the ... [more ▼]The successful application of a concrete repair system is often evaluated through pull-off testing. For such in-situ quality control (QC) testing, the inherent risk of misalignment might affect the recorded value and eventually make a difference in the acceptance of the work. So far, the issue of eccentricity in pull-off testing has been ignored in field practice, because it is seen as an academic issue. This paper presents the results of a project intended to quantify the effect of misalignment on pull-off tensile strength evaluation and provide a basis for improving QC specifications if necessary. The test program consisted first in an analytical evaluation of the problem through 2-D FEM simulations and, in a second phase, in laboratory experiments in which the test variables were the misalignment angle (0°, 2° and 4°) and the coring depth (15 mm [1.18 in.], 30 mm [2.36 in.]). It was found that calculations provide a conservative but realistic lower bound limit for evaluation the influence of misalignment upon pull-off test results: a 2° misalignment can be expect to yield a pull-off strength reduction of 7 to 9 % respectively for 15-mm [1.18-in.] and 30-mm [2.36-in.] coring depths, and the corresponding decrease resulting from a 4° misalignment reach between 13 and 16%; From a practical standpoint, the results generated in this study indicate that when specifying a pull-off strength limit in the field, the value should be increased (probable order of magnitude: 15%) to take into account the potential reduction due to testing misalignment. [less ▲]Detailed reference viewed: 12 (2 ULg) The Rank Minrelation CoefficientMeyer, Patrick in Quality Technology & Quantitative Management (2014), 11Detailed reference viewed: 17 (5 ULg) Strategies for Using the Sheep Ovarian Cortex as a Model in Reproductive MedicineFransolet, Maïté ; Labied, Soraya ; HENRY, Laurie et alin PLoS ONE (2014), 9(3), 91073Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity ... [more ▼]Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity on the experimental results. Design: Histological study. Setting: Academic research center. Animals: Five- to nine-month-old ewes. Interventions: Freshly sampled whole sheep ovaries were collected and prepared for histological analysis. Main Outcome Measure(s): The follicular densities and distributions were determined for hematoxylin and eosin sections. A mathematical model was derived based on the follicle counts and Monte-Carlo simulations. Results: Heterogeneous distributions and densities of primordial follicles were identified 1) for distinct areas of the same ovarian cortex, 2) between the ovaries of the same animal and 3) across different ewes. A mathematical model based on the analysis of 37,153 primordial follicles from 8 different ovaries facilitated the estimation of the number of cortical biopsies and sections that had to be analyzed to overcome such heterogeneity. Conclusion: The influence of physiological follicular heterogeneity on experimental and clinical results can be overcome when a definite number of cortical pieces and sections are taken into consideration. [less ▲]Detailed reference viewed: 3 (0 ULg) Effects of melody and technique on acoustical and musical features of Western operatic singing voicesLarrouy, Pauline ; Magis, David ; Morsomme, Dominique in Journal of Voice (2014)Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains ... [more ▼]Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains unclear. This study aims to further characterize the Western operatic singing technique by observing the effects of melody and technique on acoustical and musical parameters of the singing voice. Methods: Fifty professional singers performed two contrasting melodies (popular song and romantic melody) with two vocal techniques (with and without operatic singing technique). The common quality parameters (energy distribution, vibrato rate and extent), perturbation parameters (standard deviation of the fundamental frequency, signal-to-noise ratio, jitter and shimmer) and musical features (fundamental frequency of the starting note, average tempo, and sound pressure level) of the 200 sung performances were analyzed. Results: The results regarding the effect of melody and technique on the acoustical and musical parameters show that the choice of melody had a limited impact on the parameters observed, whereas a particular vocal profile appeared depending on the vocal technique employed. Conclusions: This study confirms that vocal technique affects most of the parameters examined. In addition, the observation of quality, perturbation and musical parameters contributes to a better understanding of the Western operatic singing technique. [less ▲]Detailed reference viewed: 55 (3 ULg) Influence des représentations sociales de l’environnement sur l’adoption des pratiques durables de production. Une contribution à partir du système de production de coton biologique au BéninAssogba, Sonagnon Claude-Gervais ; Tossou, Cocou Rigobert; Lebailly, Philippe in Journal of Oriental and African Studies (2014), 23Le présent article est une contribution à l’analyse des facteurs qui déterminent le comportement des producteurs dans l’odoption des pratiques durables de production de coton au Bénin. Il s’appuie sur une ... [more ▼]Le présent article est une contribution à l’analyse des facteurs qui déterminent le comportement des producteurs dans l’odoption des pratiques durables de production de coton au Bénin. Il s’appuie sur une recherche menée auprès des biocotonculteurs de la commune de Kandi dans le bassin cotonnier du Nord-Bénin. L’objectif visé est de caractériser les représentations sociales des producteurs de l’environnement et de mieux cerner en quoi elles déterminent leur comportement dans l’appropriation du système de production de coton biologique. Les données ont été collectées auprès d’un échantillon de 188 producteurs sélectionnés à partir d’une typologie à dires d’acteurs, basée sur les critères endogènes de prospérité. L’approche structurale des représentations sociales et le test d’indépendance de chi 2 ont été utilisés à cet effet. Il ressort des résultats et analyses que les producteurs de coton biologique ont une vision anthropocentrique et utilitariste de l’environnement qu’ils perçoivent comme un réservoir pourvoyeur des ressources nécessaires pour leur survie. L’adhésion des producteurs au programme de production de coton biologique est sous-tendue par des motivations d’abord économiques (40%) puis environnementales (18%) et sociales (11%). Il est apparu que le type de comportement adopté par le producteur dans la mise en œuvre des pratiques de production biologique est davantage lié aux facteurs qui motivent son adhésion. Aussi, avons-nous montré que les producteurs qui respectent mieux les exigences du système de production biologique sont ceux dont l’adhésion est principalement mue par des considérations environnementales. [less ▲]Detailed reference viewed: 39 (11 ULg) Aging Reduces the Stimulating Effect of Blue Light on Cognitive Brain FunctionsDaneault, Véronique; Hébert, Marc; Albouy, Geneviève et alin Sleep (2014)Detailed reference viewed: 25 (1 ULg) Potentiality of clay raw materials from northern Morocco in ceramic industry: Tetouan and Meknes areasEl Ouahabi, Meriam ; Daoudi, Lahcen; De Vleeschouwer, François et alin Journal of Minerals and Materials Characterization and Engineering (2014)This study aims at evaluating the potential suitability of Tetouan and Meknes (central Morocco) clay material as raw materials in various ceramic applications by investigating their textural, chemical ... [more ▼]This study aims at evaluating the potential suitability of Tetouan and Meknes (central Morocco) clay material as raw materials in various ceramic applications by investigating their textural, chemical, thermal and firing characteristics. Textural properties were identified by specific surface area, cation exchange capacity (CEC) and bulk density (ρs). Chemical and thermal properties were assessed using XRF and TG/DTA techniques, respectively. Firing characteristics at temperatures from 800°C to 1100°C were determined by linear firing shrinkage, loss on weight and water absorption capacity. The Meknes clays are characterised by medium cation exchange capacity (CEC) and specific surface area (SSA) values due to their moderate smectite content. The Tetouan clays have medium to low CEC and medium SSA values. The main oxides in the clayey samples are SiO2 (35 – 54.3 wt.%), Al2O3 (20.6 – 43.9 wt.%), and Fe2O3 (9.7 – 22.4 wt.%). The amount of CaO in Meknes clays ranges from 8 to 12 wt.%, whereas CaO is only present in some Tetouan clay (TE4, TE7, TN4 and TN5). A significant densification of ceramic behaviour could be noticed for most of Tetouan clays at firing temperatures above 1000°C. Meknes clays show earlier densification from 800 °C. The chemical, textural and ceramic properties of Tetouan and Meknes clays indicate their suitability as raw materials for the production of structural ceramics. The high amount of Fe2O3 in all clays makes them inappropriate in fine ceramics. [less ▲]Detailed reference viewed: 24 (11 ULg) Ultrathin porous pavement made with high viscosity asphalt rubber binder: A better acoustic absorption?Luong, Jeanne ; Bueno, M.; Vazquez, V.F. et alin Applied Acoustics (2014), 79his work presents a non-destructive technique applied to ultrathin porous asphalt pavements that allows us to characterize their internal structure. Comparison between acoustic absorption data from ... [more ▼]his work presents a non-destructive technique applied to ultrathin porous asphalt pavements that allows us to characterize their internal structure. Comparison between acoustic absorption data from experimental tests with an impedance tube and analytical simulation leads to an optimization of intrinsic parameters, such as tortuosity, airflow resistivity and porosity. The studied ultrathin specimens are of a high air void content porous mixture made with conventional polymer modified bituminous binder and high viscosity rubber binder. It has been found that one of the studied mixtures presents less air void con- tent than specified by the manufacturer, and thus absorbs less noise as foreseen. Finally, in this case it appears that using a high viscosity asphalt rubber binder has no influence on maximum acoustic absorp- tion but on the frequency of appearance of this maximum, tortuosity and airflow resistivity. [less ▲]Detailed reference viewed: 5 (0 ULg) Discussion of "Two-dimensional depth-averaged finite volume model for unsteady turbulent flows"Erpicum, Sébastien ; Pirotton, Michel ; Archambeau, Pierre et alin Journal of Hydraulic Research (2014), 52(1), 148-150Detailed reference viewed: 7 (2 ULg) Erratum: SN 2007uy − metamorphosis of an aspheric Type Ib explosionRoy, Rupak in Monthly Notices of the Royal Astronomical Society (2014)The supernovae (SNe) of Type Ibc are rare and the detailed characteristics of these explosions have been studied only for a few events. Unlike Type II SNe, the progenitors of Type Ibc have never been ... [more ▼]The supernovae (SNe) of Type Ibc are rare and the detailed characteristics of these explosions have been studied only for a few events. Unlike Type II SNe, the progenitors of Type Ibc have never been detected in pre-explosion images. So, to understand the nature of their progenitors and the characteristics of the explosions, investigation of proximate events are necessary. Here we present the results of multi-wavelength observations of Type Ib \sn\ in the nearby ($\sim$ 29.7 Mpc) galaxy NGC 2770. Analysis of the photometric observations revealed this explosion as an energetic event with peak absolute $R$ band magnitude $-18.5\pm0.16$, which is about one mag brighter than the mean value ($-17.6\pm0.6$) derived for well observed Type Ibc events. The SN is highly extinguished, \ebv\ = 0.63$\pm$0.15 mag, mainly due to foreground material present in the host galaxy. From optical light curve modeling we determine that about 0.3 \msun\ radioactive $^{56}$Ni is produced and roughly 4.4 \msun\ material is ejected during this explosion with liberated energy $\sim 15\times10^{51}$ erg, indicating the event to be an energetic one. Through optical spectroscopy, we have noticed a clear aspheric evolution of several line forming regions, but no dependency of asymmetry is seen on the distribution of $^{56}$Ni inside the ejecta. The SN shock interaction with the circumburst material (CSM) is clearly noticeable in radio follow-up, presenting a Synchrotron Self Absorption (SSA) dominated light curve with a contribution of Free Free Absorption (FFA) during the early phases. Assuming a Wolf-Rayet (WR) star, with wind velocity $\ga 10^3 {\rm km~s}^{-1}$, as a progenitor, we derive a lower limit to the mass loss rate inferred from the radio data as $\dot{M} \ga 2.4\times10^{-5}$ \msun\,~yr$^{-1}$, which is consistent with the results obtained for other Type Ibc SNe bright at radio frequencies. [less ▲]Detailed reference viewed: 9 (3 ULg) Simultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometryDewalque, Lucas ; PIRARD, Catherine ; DUBOIS, Nathalie et alin Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2014), 949-950Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to ... [more ▼]Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to some hormonal diseases. Numerous large-scale biomonitoring studies have detected the biomarkers of these compounds in more than 75% of the general population. To assess the exposure to these chemicals, we developed an analytical method based on a Solid Phase Extraction (SPE) prior to ultra high pressure liquid chromatographytandem mass spectrometry (UPLC-MS/MS) for the simultaneous measurement of seven phthalate metabolites (monobenzyl phthalate, mono-n-butyl phthalate, mono-iso-butyl phthalate, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2- ethyl-5-oxohexyl phthalate, monoethyl phthalate), four parabens (methyl paraben, ethyl paraben, n-propyl paraben, n-butyl parabens) and benzophenone-3 in human urine. The distinction between unconjugated, glucuro- and sulfoconjugated forms was achieved using different enzymatic hydrolyses. The whole procedure was validated according to the total error approach, and was demonstrated to be linear (regression coefficient ranging from 0.987 to 0.998) and accurate (inter and intra assay precision <17.71%, relative bias <5.87%) in the dosing range of concentrations. The limits of quantification (LOQs) obtained ranged between 0.30 and 1.23 ng/ml depending on the analyte. The reliability of the method was proven in passing successfully the German External Quality Assessment Scheme (G-EQUAS). Moreover, the urine from 25 volunteers were analyzed for the determination of glucuro-, sulfo- and free species separately. Phthalate metabolites, parabens and benzophenone-3 were positively detected in almost all urine samples, with detection rates ranging from 40 to 100%. Levels measured ranged from Figures Reference QuickView Add to ACS ChemWorx Ian H. Bell *†, Jorrit Wronski *‡, Sylvain Quoilin *†, and Vincent Lemort *† † Energy Systems Research Unit, University of Liège, Liège, Belgium ‡ Department of Mechanical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark Ind. Eng. Chem. Res., 2014, 53 (6), pp 2498–2508 DOI: 10.1021/ie4033999 Publication Date (Web): January 13, 2014 Copyright © 2014 American Chemical Society OpenURL UNIV DE LIEGE *E-mail: ian.bell@ulg.ac.be., *E-mail: jowr@mek.dtu.dk., *E-mail: squoilin@ulg.ac.be., *E-mail: vincent.lemort@ulg.ac.be. ACS AuthorChoice Abstract Over the last few decades, researchers have developed a number of empirical and theoretical models for the correlation and prediction of the thermophysical properties of pure fluids and mixtures treated as pseudo-pure fluids. In this paper, a survey of all the state-of-the-art formulations of thermophysical properties is presented. The most-accurate thermodynamic properties are obtained from multiparameter Helmholtz-energy-explicit-type formulations. For the transport properties, a wider range of methods has been employed, including the extended corresponding states method. All of the thermophysical property correlations described here have been implemented into CoolProp, an open-source thermophysical property library. This library is written in C++, with wrappers available for the majority of programming languages and platforms of technical interest. As of publication, 110 pure and pseudo-pure fluids are included in the library, as well as properties of 40 incompressible fluids and humid air. The source code for the CoolProp library is included as an electronic annex. [less ▲]Detailed reference viewed: 26 (4 ULg) TRAITEMENT CONSERVATEUR DES CANCERS INFILTRANTS DE LA VESSIEWERENNE, Xavier ; COUCKE, Philippe in Revue Médicale de Liège (2014), 69(Supp 1), 69-74Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement ... [more ▼]Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement «standard» des cancers infiltrants de la vessie. Cependant, elle est liée à un taux élevé de complications et à une altération de la qualité de vie, en particulier, chez les patients âgés présentant de nombreuses comorbidités. Le but de cet article est de déterminer les alternatives conservatrices et de préciser à quels patients elles doivent être réservées, en particulier, l’approche trimodale (résection trans-uréthrale et radio-chimiothérapie) et la cystectomie partielle précédée de radio-chimiothérapie [less ▲]Detailed reference viewed: 21 (5 ULg) Exciton dissociation at donor-acceptor heterojunctions: Dynamics using the collective effective mode representation of the spin-boson modelChenel, Aurélie; Mangaud, Etienne; Burghardt, Irène et alin Journal of Chemical Physics (2014), 140Detailed reference viewed: 4 (0 ULg) Mesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et alin Nephrology Dialysis Transplantation (2014)Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]Detailed reference viewed: 9 (2 ULg) Endocrine disruptors: A relevant issue for neuroendocrinology also!Balthazart, Jacques ; Levine, Jon E.in Frontiers in neuroendocrinology (2014), 35(1), 1Detailed reference viewed: 6 (1 ULg) DIMENSIONNEMENT ET EXPÉRIMENTATION D’UNE UNITÉ POMPE À CHALEUR / ORC RÉVERSIBLEDumont, Olivier ; Quoilin, Sylvain ; Lemort, Vincent in Procceding du septième édition du colloque francophone en énergie, environnement, économie et thermodynamique 2014 (2014)L’union européenne doit réduire les émissions de gaz à effet de serre de 80% par rapport au niveau des années 90 d’ici 2020. Les ménages représentent 27% de la consommation finale. Dans ce cadre, les ... [more ▼]L’union européenne doit réduire les émissions de gaz à effet de serre de 80% par rapport au niveau des années 90 d’ici 2020. Les ménages représentent 27% de la consommation finale. Dans ce cadre, les bâtiments dont la consommation d’énergie est quasi nulle (NZEB – Nearly Zero Energy Building) sont d’une importance considérable. A partir de 2019, tous les nouveaux bâtiments devront présenter une production d’énergie renouvelable supérieure à la consommation d’énergie primaire. C’est dans ce cadre que le concept de PAC/ORC prend tout son sens. Ce système innovant comprend une pompe à chaleur eau/eau (PAC) reliée à un toit solaire et à un échangeur de chaleur géothermique. Cette pompe à chaleur est également capable d'inverser son cycle et de fonctionner comme un Cycle Organique de Rankine (ORC). En utilisant le toit solaire comme source de chaleur, une grande quantité de chaleur est générée tout au long de l'année. Cette chaleur est utilisée en priorité pour couvrir les besoins de chauffage annuels et le surplus de chaleur généré au cours de l'été est utilisée pour produire de l'électricité dans l’unité PAC / ORC. L’article s’articule en 4 parties. Tout d’abord, l’introduction présente les trois modes de fonctionnement. Ensuite, les modèles des composants et l’évaluation des performances au point nominal de conception sont décrits. Par après, le dimensionnement et le choix des composants sont réalisés sur bases de simulations annuelles avec un pas de temps d’une heure. Enfin, les premiers résultats expérimentaux sont présentés. Un rendement de 5,7% est atteint en mode ORC (avec une température de condensation de 25°C et une température d’évaporation de 88°C) alors qu’un COP de 4,2 est obtenu en mode pompe à chaleur (avec une température de condensation de 61°C et une température d’évaporation de 21°C). [less ▲]Detailed reference viewed: 10 (2 ULg) Château fort d’Ecaussinnes-Lalaing (Hainaut) : de nouveaux matériaux pour une chronologie du bâtiMaggi, Christophe ; Blain, Sophie ; Bavay, Gérard et alin Bulletin de la Commission royale des Monuments, Sites et Fouilles (2014), 25Situé dans le Hainaut, dominant le vallon de la Senette, le château-fort d’Écaussinnes a fait l’objet de diverses monographies. Pourtant, bien des études du bâti restent à faire, dans la foulée de la plus ... [more ▼]Situé dans le Hainaut, dominant le vallon de la Senette, le château-fort d’Écaussinnes a fait l’objet de diverses monographies. Pourtant, bien des études du bâti restent à faire, dans la foulée de la plus récente que l’on doit à Philippe Sosnowska. En mars 2012, une étude typologique et dendrochronologique des charpentes, à l’occasion de travaux de restauration aux toitures, apporte quelques éléments nouveaux. L’analyse porte sur les charpentes de toiture de la chapelle et des ailes ouest et nord. Elle a été demandée par les architectes Paul Delaisse et Michel Micciche dans le cadre de la restauration des toitures. [less ▲]Detailed reference viewed: 10 (2 ULg) Optical study of a solar concentrator for space applications based on a diffractive/refractive optical combinationMichel, Céline ; Loicq, Jerôme ; Languy, Fabian et alin Solar Energy Materials & Solar Cells (2014), 120PAThis paper presents a new design of a planar solar concentrator for space applications. The concentrator focuses light onto two spatially separated photovoltaic cells, allowing for independent control of ... [more ▼]This paper presents a new design of a planar solar concentrator for space applications. The concentrator focuses light onto two spatially separated photovoltaic cells, allowing for independent control of the output power of each cell. Thanks to a blazed diffraction grating superimposed on a Fresnel lens, advantages of both spectral splitting and light focusing can be combined. The theoretical model of the optical design is presented, with the optimization of either element. Moreover, conﬁguration improvement is proposed: a symmetrical conﬁguration composed of two lenses. First numerical results are presented, highlighting the possibility to design a concentrator at about 10× for each cell, with an optical efficiency of about 75% and less than 10% of losses for tracking errors lower than ±0.9°. [less ▲]Detailed reference viewed: 42 (23 ULg) Sartre à Venise, l’homme qui allait vers le froid. Sur La Reine Albemarle ou le dernier touriste (1951-1952)Cormann, Grégory in Temps Modernes (Les) (2014)Detailed reference viewed: 18 (5 ULg) A propos de l'encéphalopathie du nouveau-néBattisti, Oreste ; Beguin, Yves in Percentile (2014)editorial sur l'hypoxie périnatale et les cellules souches.Detailed reference viewed: 29 (1 ULg) Modulating effect of COMT genotype on the brain regions underlying proactive control process during inhibitionJaspar, Mathieu ; Genon, Sarah ; Muto, Vincenzo et alin Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 50Introduction. Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions ... [more ▼]Introduction. Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to three groups of 15 young adults according to their COMT Val158Met genotype [Val/Val (VV), Val/Met (VM) and Met/Met (MM)]. Based on the theory of dual mechanisms of control (Braver, et al., 2007), the Stroop task has been built to induce proactive or reactive control processes according to the task context. Results. Behavioral results did not show any significant group differences for reaction times but Val allele carriers individuals are less accurate in the processing of incongruent items. fMRI results revealed that proactive control is specifically associated with increased activity in the anterior cingulate cortex (ACC) in carriers of the Met allele, while increased activity is observed in the middle frontal gyrus (MFG) in carriers of the Val allele. Conclusion. These observations, in keeping with a higher cortical dopamine level in MM individuals, support the hypothesis of a COMT Val158Met genotype modulation of the brain regions underlying proactive control, especially in frontal areas as suggested by Braver et al. [less ▲]Detailed reference viewed: 46 (18 ULg) Complex dynamics of a nonlinear aerospace structure: experimental identification and modal interactionsNoël, Jean-Philippe ; Renson, Ludovic ; Kerschen, Gaëtan in Journal of Sound & Vibration (2014), 333Nonlinear system identification is a challenging task in view of the complexity and wide variety of nonlinear phenomena. The present paper addresses the identification of a real-life aerospace structure ... [more ▼]Nonlinear system identification is a challenging task in view of the complexity and wide variety of nonlinear phenomena. The present paper addresses the identification of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. The complete identification procedure, from nonlinearity detection and characterization to parameter estimation, is carried out based upon experimental data. The combined use of various analysis techniques, such as the wavelet transform and the restoring force surface method, brings different perspectives to the dynamics. Specifically, the structure is shown to exhibit particularly interesting nonlinear behaviors, including jumps, modal interactions, force relaxation and chattering during impacts on the mechanical stops. [less ▲]Detailed reference viewed: 33 (13 ULg) Monitoring batch lipase catalyzed interesterification of palm oil and fractions by differential scanning calorimetryDanthine, Sabine ; DeClercq, Nathalie; Dewettinck, Koen et alin Journal of Thermal Analysis and Calorimetry (2014)Detailed reference viewed: 16 (3 ULg) Evaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations.Scheen, André in Expert opinion on drug metabolism & toxicology (2014)Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 ... [more ▼]Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Areas covered: An extensive literature search was performed to analyze the pharmacokinetic characteristics, toxicological issues and safety concerns of SGLT2 inhibitors in humans. This review focuses on three compounds (dapagliflozin, canagliflozin, empagliflozin) with results obtained in healthy volunteers (including drug-drug interactions), patients with T2DM (single dose and multiple doses) and special populations (those with renal or hepatic impairment). Expert opinion: The three pharmacological agents share an excellent oral bioavailability, long half-life allowing once-daily administration, low accumulation index and renal clearance, the absence of active metabolites and a limited propensity to drug-drug interactions. No clinically relevant changes in pharmacokinetic parameters were observed in T2DM patients or in patients with mild/moderate renal or hepatic impairment. Adverse events are a slightly increased incidence of mycotic genital and rare benign urinary infections. SGLT2 inhibitors have the potential to reduce several cardiovascular risk factors, and cardiovascular outcome trials are currently ongoing. The best positioning of SGLT2 inhibitors in the armamentarium for treating T2DM is still a matter of debate. [less ▲]Detailed reference viewed: 15 (1 ULg) RADIOTHÉRAPIE MAMMAIRE- pret-à-porter ou sur mesure ?COUCKE, Philippe ; LAKOSI, Ferenc in Revue Médicale de Liège (2014), 69(Supp 1), 81-86La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très ... [more ▼]La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très bien codifiée et peut être taxée de «prêt-à-porter». Et pourtant, on est en droit de se poser la question s’il est possible de concevoir des indications de traitement «sur mesure». A ce jour, les données de la littéra - ture nous incitent à la prudence. Dans aucun cas de figure, on n’a été capable de démontrer que la radiothérapie pouvait être éliminée de l’approche thérapeutique sans pour autant risquer une augmentation significative du taux de rechute locale. Même si on considère que la radiothérapie adjuvante est une approche standard après une chirurgie conservatrice, il n’en reste pas moins qu’il persiste un certain nombre de questions ouvertes. Ces traitements actiniques pourraient être modulables en fonction des caractéristiques des patientes et des tumeurs. Idéalement, nous aimerions disposer de mar - queurs pronostiques et prédictifs robustes afin de détermi - ner qui il faut soumettre à ce traitement adjuvant. Peut-être que des signatures géniques vont permettre de sélectionner les patientes. Ces signatures géniques ne font pas l’unanimité quant à leur réelle portée clinique [less ▲]Detailed reference viewed: 8 (0 ULg) New role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.Deroyer, Céline ; Deroyer, Céline ; Renert, Anne-Françoise et alin Autophagy (2014)To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]Detailed reference viewed: 57 (0 ULg) Response to Dr Bolland's eLetter: Strontium and cardiovascular events.REGINSTER, Jean-Yves in Annals of the rheumatic diseases (2014), 73(2), 9Detailed reference viewed: 6 (2 ULg) United but (un)equal: human capital, probability of divorce, and the marriage contractCremer, Helmuh; Pestieau, Pierre ; Roeder, Kerstinin Journal of Population Economics (2014)Detailed reference viewed: 17 (0 ULg) ÉLABORATION D’UN PLAN DE FORMATION CONTINUE À PARTIR DE L’APPROCHE PROCESSUS DANS UN SERVICE DE RADIOTHÉRAPIELENAERTS, Eric ; DELGAUDINE, Marie ; COUCKE, Philippe in Revue Médicale de Liège (2014), 69(Supp 1), 104-110Pour garantir l’intégration des évolutions technolo - giques régulières et des changements organisationnels qui en découlent, le Service de Radiothérapie du CHU de Liège, s’est engagé depuis 2007 dans la ... [more ▼]Pour garantir l’intégration des évolutions technolo - giques régulières et des changements organisationnels qui en découlent, le Service de Radiothérapie du CHU de Liège, s’est engagé depuis 2007 dans la définition et la coordination d’une politique de qualité des soins et de sécurité du patient cohérente et globale. L’équipe dirigeante du service considère la gestion des compétences comme un impératif indispensable afin de pouvoir intégrer rapidement l’utilisation des nouvelles tech - nologies de traitement tout en fournissant de manière continue des soins de haute qualité aux patients. L’approche « proces - sus » consiste à décrire, de façon méthodique, une organisation en processus en vue de contribuer à la satisfaction du patient. Cette approche appliquée dans le service de radiothérapie a permis une meilleure visibilité du fonctionnement du service ainsi qu’une meilleure maîtrise des relations entre les collabo - rateurs et avec les patients. Elle permet de maîtriser la valeur ajoutée de chaque processus, d’identifier les points de risques et d’en anticiper les dérives. Plus précisément, l’approche processus a conduit à préciser les compétences requises pour garantir une haute qualité des soins et à concevoir un plan de formation continue spécifique aux besoins d’un service de radiothérapie. Ce plan a été reconnu au travers de la création d’un certificat universitaire spécifique [less ▲]Detailed reference viewed: 8 (0 ULg) INDICATIONS D’UN TRAITEMENT DE RADIOTHERAPIE LOCALE APRES PROSTATECTOMIE RADICALEHERMESSE, Johanne ; WERENNE, Xavier ; PHILIPPI, Sven et alin Revue Médicale de Liège (2014), 69(Supp 1), 29-31Detailed reference viewed: 5 (1 ULg) Functionalization of carbon xerogels for the preparation of palladium supported catalysts applied in sugar transformationsMager, Nathalie; Meyer, Nathalie; Léonard, Alexandre et alin Applied Catalysis B : Environmental (2014), 148-149Detailed reference viewed: 31 (5 ULg) LA CURIETHÉRAPIE PROSTATIQUE PAR IMPLANTS PERMANENTS D'IODE 125- résultats après 10 ans d'expérience au CHU de LiègeHERMESSE, Johanne ; NICKERS, Philippe; REUL, Olivier et alin Revue Médicale de Liège (2014), 69(Supp 1), 32-36La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement ... [more ▼]La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement chirurgical. La survie globale et la survie sans récidive biochimique y sont superposables, mais le profil de toxicité est différent. La plus grande opportunité de préservation de la fonction érectile, la diminution du risque d’incontinence et l’hospitalisation de jour peuvent être inté - ressantes pour le patient optant pour la curiethérapie. Par contre, la présence d’un syndrome obstructif urinaire de départ devrait orienter préférentiellement vers un traitement chirurgical. Un patient doit pouvoir faire un choix éclairé entre ces différentes possibilités thérapeutiques moyennant une information transparente et complète. Dans cet exposé, nous relatons notre expérience en curiethérapie par implants permanents d’iode 125. La survie globale, la survie libre sans récidive biochimique à long terme et la toxicité enregistrée sont similaires à celles décrites dans la littérature. [less ▲]Detailed reference viewed: 5 (0 ULg) Cuando la Historia se hace historia: (re)creación de Pancho Villa por Nellie Campobello en los Apuntes sobre la vida militar de Francisco Villa (1940)François, Jéromine in Anales de Literatura Hispanoamericana (2014), 43Detailed reference viewed: 26 (3 ULg)