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See detailClinically relevant subgroups in COPD and asthma.
Turner, Alice M.; Tamasi, Lilla; SCHLEICH, FLorence ULg et al

in European respiratory review : an official journal of the European Respiratory Society (2015), 24(136), 283-98

As knowledge of airways disease has grown, it has become apparent that neither chronic obstructive pulmonary disease (COPD) nor asthma is a simple, easily defined disease. In the past, treatment options ... [more ▼]

As knowledge of airways disease has grown, it has become apparent that neither chronic obstructive pulmonary disease (COPD) nor asthma is a simple, easily defined disease. In the past, treatment options for both diseases were limited; thus, there was less need to define subgroups. As treatment options have grown, so has our need to predict who will respond to new drugs. To date, identifying subgroups has been largely reported by detailed clinical characterisation or differences in pathobiology. These subgroups are commonly called "phenotypes"; however, the problem of defining what constitutes a phenotype, whether this should include comorbid diseases and how to handle changes over time has led to the term being used loosely. In this review, we describe subgroups of COPD and asthma patients whose clinical characteristics we believe have therapeutic or major prognostic implications specific to the lung, and whether these subgroups are constant over time. Finally, we will discuss whether the subgroups we describe are common to both asthma and COPD, and give some examples of how treatment might be tailored in patients where the subgroup is clear, but the label of asthma or COPD is not. [less ▲]

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See detailAn echographic study of follicular growth during induced estrus in female Azawak zebu in Niger
Moussa Garba, Mahamadou; Moumouni, Issa; Hamani, Marichatou et al

in Tropical Animal Health and Production (2015)

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See detailCrystal structure of arsenuranospathite from Rabejac, Lodève, France
Dal Bo, Fabrice ULg; Hatert, Frédéric ULg; Baijot, Maxime ULg et al

in European Journal of Mineralogy (2015), 27

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See detail'Een lent van vaerzen' als letterkundig spiegelkabinet
Steyaert, Kris ULg

in Arabesken: Tijdschrift van het Louis Couperus Genootschap (2015), 23(45), 22-28

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See detailMen in childcare services: From enrolment in training programs to job retention
Pirard, Florence ULg; Schoenmaeckers, Pauline ULg; Camus, Pascale

in European Early Childhood Education Research Journal (2015)

This article presents a study conducted in Federation Wallonia-Brussels (FWB) to identify factors that motivate men to enrol in training programmes and work in a field where women are the majority, in a ... [more ▼]

This article presents a study conducted in Federation Wallonia-Brussels (FWB) to identify factors that motivate men to enrol in training programmes and work in a field where women are the majority, in a context in which few proactive measures are taken to overcome gender stereotypes. Comprehensive interviews conducted with male childcare ‘informants’ who had been working with children under the age of three for at least a year in subsidised childcare centres helped us to identify factors which seemed to influence their decision to enrol in and continue an initial training programme with a curriculum that is not genderneutral, and then work in a profession that is almost exclusively female. [less ▲]

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See detailLe marché des radicaux libres. Sur quelques conditions médiatiques de la posture « néo-réactionnaire ».
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (2015), 87(printemps), 101-118

Years 1990-2000 could be characterized in France by the emergence of a current of thought and a nebula of intellectual actors collectively gathered under the label of the « New Reactionaries » since the ... [more ▼]

Years 1990-2000 could be characterized in France by the emergence of a current of thought and a nebula of intellectual actors collectively gathered under the label of the « New Reactionaries » since the publication of the controversial pamphlet, Le Rappel à l’ordre, by Daniel Lindenberg in 2002. Journalists, novelists, essayists, columnists, philosophers, showing a posture of refusal towards the « politically correct », the « moral left » and the « dominant ideology », they can be viewed as a kind of generic character, made up of peculiarities breaking away from any sociological assignment. The topics of this discourse tend to be analyzed from a point of view not included within the concerned polemical filed. The aim of this paper is to contribute to such an analysis by pointing out the transformations of the journalistic and publishing field from which the « new reactionaries » draw some of their powerful polemical efficiency. [less ▲]

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See detailEarly evolution of large microorganisms with cytological complexity revealed by microanalyses of 3.4 Ga organic-walled microfossils.
Sugitani; Mimura, K; Takeuchi, M et al

in Geobiology (2015)

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See detailLouis Althusser. Politique et subjectivité. Editorial
Bruschi, Fabio; Mancuso, Eva ULg

in Cahiers du GRM (2015), VII

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See detailShort-term responses of glass eels transported from UK to small Belgian streams
Ovidio, Michaël ULg; Tarrago-Bes, Frédérique; Nzau Matondo, Billy ULg

in Annales de Limnologie = International Journal of Limnology (2015)

Restocking of inland waters with glass eels is one of the recovery options to prevent the decline of European eel Anguilla anguilla (L.) populations. We studied the growth, dispersion, density and habitat ... [more ▼]

Restocking of inland waters with glass eels is one of the recovery options to prevent the decline of European eel Anguilla anguilla (L.) populations. We studied the growth, dispersion, density and habitat preferences in the imported glass eels from United-Kingdom and stocked in three typologically different small Belgian streams, using electrofishing surveys around the single release point, 1 year following stocking. Our results clearly support that the recaptured individuals stocked in our streams farther from the sea, survived, grew, dispersed upstream and downstream. Elvers exploited the complete transversal section of stream, with preference for the sheltered microhabitats near the banks with slower water velocity and low depth. Length-weight relationship was different between streams in terms of allometric coefficient (b). We assume that microhabitats and food availabilities lead to contrasted results in terms of growth and absolute occurrence. Restocking of glass eels in small middle-land streams was found to be an interesting and unconventional option that requires adequate stream and habitat selection. [less ▲]

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See detailThe strength of multi-row models
Louveaux, Quentin ULg; Poirrier, Laurent; Salvagnin, Domenico

in Mathematical Programming Computation (2015), 7(2), 113-148

We develop a method for computing facet-defining valid inequalities for any mixed-integer set PJ. Our practical implementation does not return only facet- defining inequalities, but it is able to find a ... [more ▼]

We develop a method for computing facet-defining valid inequalities for any mixed-integer set PJ. Our practical implementation does not return only facet- defining inequalities, but it is able to find a separating cut whenever one exists. The separator is not comparable in speed with the specific cutting-plane generators used in branch-and-cut solvers, but it is general-purpose. We can thus use it to compute cuts derived from any reasonably small relaxation PJ of a general mixed- integer problem, even when there exists no specific implementation for computing cuts with PJ. Exploiting this, we evaluate, from a computational perspective, the usefulness of cuts derived from several types of multi-row relaxations. In particular, we present results with four different strengthenings of the two-row intersection cut model, and multi-row models with up to fifteen rows. We conclude that only fully-strengthened two-row cuts seem to offer a significant advantage over two-row intersection cuts. Our results also indicate that the improvement obtained by going from models with very few rows to models with up to fifteen rows may not be worth the increased computing cost. [less ▲]

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See detailGroupes délinquants juvéniles, quelle méthode pour une recherche « ethno-criminologique » ? La loi des 4 C
Witvrouw, Line ULg; Glowacz, Fabienne ULg

in Revue Internationale de Criminologie et de Police Technique et Scientifique [= RICPTS] (2015), LXVIII(Avril-Juin), 196-209

La criminologie nous amène à travailler avec des populations difficiles d’accès et requiert une démarche méthodologique structurée et prenant en compte les caractéristiques du milieu de rencontre. A ... [more ▼]

La criminologie nous amène à travailler avec des populations difficiles d’accès et requiert une démarche méthodologique structurée et prenant en compte les caractéristiques du milieu de rencontre. A partir de notre recherche portant sur les groupes de jeunes délinquants ou déviants, une spécificité est apparue dès le début des démarches empiriques. En effet, une notion d’exclusivité est entendue entre chaque membre du groupe, rendant l’accès à l’information difficile tant les frontières de ce groupe vis-à-vis de l’extérieur sont imperméables. Le chercheur se trouve alors confronté à différents obstacles: la difficulté de prise de contacts avec les groupes, la difficulté d’intégration du chercheur au sein de ceux-ci et la difficulté de récolte de données suffisantes pour la recherche. Au vu des constats de terrain, nous avons développé une méthodologie spécifique inspirée de modèles ethnologiques. En prenant en compte les jeunes en tant qu’experts de leur vécu et les intervenants médiateurs d’inclusion sur un terrain, ce processus méthodologique relève d’une co-construction de trois pôles et partenaires et s’apparente à une approche ethno-criminologique. Ce processus par étapes se décline en séquences temporelles successives. Tout d’abord, le positionnement du chercheur comme non-détenteur du savoir, la triangulation de la relation, l’acceptation de la temporalité de la démarche et de l’instrumentalisation de la relation sont autant d’éléments constituant l’étape préalable de ce processus méthodologique. Les étapes suivantes se construisent sur la base de l’évolution du lien entre le chercheur et les jeunes. La loi des 4 C réunit ces étapes, la relation évoluant de la confiance, à la confidence, ensuite à la communication pour aboutir à la coopération [less ▲]

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See detailMultiple analyses of microbial communities applied to the gut of the wood-feeding termite Reticulitermes flavipes fed on artificial diets
Tarayre, Cédric ULg; Bauwens, Julien ULg; Mattéotti, Christel et al

in Symbiosis (2015)

The purpose of this work was the observation of the differences between the microbial communities living in the gut of the termite Reticulitermes flavipes fed on different diets. The termites were fed on ... [more ▼]

The purpose of this work was the observation of the differences between the microbial communities living in the gut of the termite Reticulitermes flavipes fed on different diets. The termites were fed on poplar wood (original diet) and artificial diets consisting of crystalline cellulose (with and without lignin), α-cellulose (with and without lignin) and xylan. The termites were then dissected and the protist communities were analyzed through microscopy, leading to the conclusion that protist species are strongly influenced by diets. BIOLOG ECO Microplates® were used to assess the metabolic properties of the different types of consortia, highlighting strong differences on the basis of principal component analysis and calculation of similarity rates. The microorganisms were cultivated in liquid media corresponding to the artificial diets before being characterized through a metagenetic analysis of gut microbiota (16S ribosomal DNA). This analysis identified several phyla: Acidobacteria, Actinobacteria, Bacteroidetes, Cyanobacteria, Fibrobacteres, Firmicutes, Nitrospirae, OP9, Planctomycetes, Proteobacteria, Spirochaetes, TM6, Tenericutes, Verrucomicrobia and WS3. The OTUs were also determined and confirmed the abundance of Proteobacteria, Bacteroidetes, Firmicutes and Verrucomicrobia. It was possible to isolate several strains from the liquid media, and one bacterium and several fungi were found to produce interesting enzymatic activities. The bacterium Chryseobacterium sp. XAvLW produced α-amylase, β-glucosidase, endo-1,4-β-D-glucanase, endo-1,4-β-D-xylanase and filter paper-cellulase, while the fungi Sarocladium kiliense CTGxxyl and Trichoderma virens CTGxAviL generated the same activities added with endo-1,3-β-D-glucanase. [less ▲]

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See detailAvis 2/13 de la CJUE : l'obsession du contrôle ?
Petit, Nicolas ULg; Pilorge, Joëlle ULg

in Revue des Affaires Européennes [= RAE] = Law & European Affairs (2015)

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See detailA comparative study of triaxial and uniaxial magnetic shields made out of YBCO coated conductors
Wera, Laurent ULg; Fagnard, Jean-François ULg; Levin, George et al

in Superconductor Science and Technology (2015), 28

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See detailTerrestrial OH nightglow measurements during the Rosetta flyby
Migliorini, A.; Gérard, Jean-Claude ULg; Soret, Lauriane ULg et al

in Geophysical Research Letters (2015), 42

We present a study of the terrestrial hydroxyl nightglow emissions observed with the Visible and Infrared Thermal Imaging Spectrometer on board the Rosetta mission. During these observations, the OH Δv  ... [more ▼]

We present a study of the terrestrial hydroxyl nightglow emissions observed with the Visible and Infrared Thermal Imaging Spectrometer on board the Rosetta mission. During these observations, the OH Δv = 1 and 2 sequences were measured simultaneously. This allowed investigating the relative population of the v = 1 to 9 vibrational levels by using both sequences. In particular, the relative population of the vibrational level v = 1 is determined for the first time from observations. The vibrational population decreases with increasing vibrational quantum number. A good agreement is found with a recent model calculation assuming multiquantum relaxation for OH(v) quenching by O2 and single-quantum relaxation for OH(v) by N2. [less ▲]

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See detailLe millénaire liturgique de l'abbatiale bénédictine de Saint-Jacques de Liège. Samedi 25 juillet 1030
George, Philippe ULg

in Trésor de Liège. Bulletin trimestriel (2015), 43(juin 2015), 7-9

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See detailEGFR and NF-kB: partners in cancer
Shostak, Kateryna ULg; Chariot, Alain ULg

in Trends in Molecular Medicine (2015), 21

Oncogenic proteins cooperate to promote tumor development and progression by sustaining cell proliferation, survival and invasiveness. Constitutive EGFR and NF-kappaB activities are seen in multiple solid ... [more ▼]

Oncogenic proteins cooperate to promote tumor development and progression by sustaining cell proliferation, survival and invasiveness. Constitutive EGFR and NF-kappaB activities are seen in multiple solid tumors and combine to provide oncogenic signals to cancer cells. Understanding how these oncogenic pathways are connected is critical, given their role in intrinsic or acquired resistance to targeted anti-cancer therapies. We review molecular mechanisms by which both EGFR- and NF-kappaB-dependent pathways establish positive loops to increase their oncogenic potential. We also describe how NF-kappaB promotes resistance to EGFR inhibitors. [less ▲]

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See detailExperimental investigation of a reversible heat pump / organic Rankine cycle unit designed to be coupled with a passive house (Net Zero Energy Building)
Dumont, Olivier ULg; Quoilin, Sylvain ULg; Lemort, Vincent ULg

in International Journal of Refrigeration (2015), 54

This paper presents an innovative reversible Heat Pump/Organic Rankine Cycle (HP/ORC) experimental unit designed to be coupled to a Net Zero Energy Building (connected to a 120 m2 thermal solar roof and a ... [more ▼]

This paper presents an innovative reversible Heat Pump/Organic Rankine Cycle (HP/ORC) experimental unit designed to be coupled to a Net Zero Energy Building (connected to a 120 m2 thermal solar roof and a ground heat exchanger). The system can operate in three different modes: an ORC mode to produce electricity when a large amount of heat is collected by the solar roof, a direct heating mode using exclusively the solar roof, and a HP mode for space heating during cold weather conditions. This paper describes a comprehensive experimental campaign carried out on a prototype unit using a modified HVAC scroll compressor (4 kWe). From the results, the technical feasibility of the system is demonstrated. A cycle efficiency of 4.2% is achieved in ORC mode (with condensation and evaporation temperature respectively of 25 C and 88 C) and a COP of 3.1 is obtained in HP mode (with condensation and evaporation temperature respectively of 61 C and 21 C). [less ▲]

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See detailLes prix de traduction fabriquent-ils une image régulatrice du traducteur ?
Mogollon Zapata, Juan Manuel ULg; Valéry, Plouhinec

in Convergences francophones (2015), 2

Les prix de traduction participent à la fois aux luttes pour la détention d’un capital de consécration et à la construction de l’image publique du traducteur. Ils sont une excellente entrée pour mesurer ... [more ▼]

Les prix de traduction participent à la fois aux luttes pour la détention d’un capital de consécration et à la construction de l’image publique du traducteur. Ils sont une excellente entrée pour mesurer les discours qui circulent dans l’espace du livre sur le traducteur et sa pratique. Comment ces prix construisent-ils une image légitimante du traducteur ? Quels critères guident le choix des jurys et quels dispositifs discursifs les justifient ? Quelles retombées pour les traducteurs et l’image de la traduction en général ? À travers l’analyse de nombreux exemples, cet article cherche à établir la manière dont les prix de traduction produisent un discours légitimant sur la figure du traducteur qui contribue à la fabrication de son image. [less ▲]

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See detailQuaternary prevention: first, do not harm - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-3

Clinical prevention, under the influence of public health, has been organised in a chronological manner since the middle of the 20th century. A paradigm shift from a chronological to a constructivist ... [more ▼]

Clinical prevention, under the influence of public health, has been organised in a chronological manner since the middle of the 20th century. A paradigm shift from a chronological to a constructivist relationship-based preventive pattern of care offers new insights into the practice of doctors. This paradigm shift brings to light the concept of quaternary prevention, a critical look at medical activities with an emphasis on the need not to harm. Quaternary prevention addresses the fundamental question of what constitutes too much or too little medicine. It is the fourth form of disease prevention, but also the fourth frame of action for family doctors [less ▲]

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See detailTeaching and learning Quaternary prevention
Gomes, Luis Enrique; Gusso, Gustavo; Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-14

This article presents an overview of different techniques and skills required for teaching and learning quaternary prevention (P4). It adopts the Expertise Model that defines the competences required in ... [more ▼]

This article presents an overview of different techniques and skills required for teaching and learning quaternary prevention (P4). It adopts the Expertise Model that defines the competences required in P4 for each level: novice, competent, proficient, and expert. This should be used as a step-wise roadmap for teachers in order to achieve high standard levels of performance. This is complemented by a list of methods used in teaching and assessment of learners’ performance and competence. By covering a range of learning and teaching issues, those who aim to teach quaternary prevention can explore the proposed framework. Quaternary prevention is a research and teaching fertile medical field that requires the integration of different areas such as health service organization, epidemiology, communication skills, and andragogy either at the macro or the micro levels health related activities. [less ▲]

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See detailChitosan enriched three-dimensional matrix reduces inflammatory and catabolic mediators production by human chondrocytes
Oprenyeszk, Frédéric ULg; Sanchez, Christelle ULg; Dubuc, Jean-Emile et al

in PLoS ONE (2015), 10(5),

This in vitro study investigated the metabolism of human osteoarthritic (OA) chondrocytes encapsulated in a spherical matrix enriched of chitosan. Human OA chondrocytes were encapsulated and cultured for ... [more ▼]

This in vitro study investigated the metabolism of human osteoarthritic (OA) chondrocytes encapsulated in a spherical matrix enriched of chitosan. Human OA chondrocytes were encapsulated and cultured for 28 days either in chitosan-alginate beads or in alginate beads. The beads were formed by slowly passed dropwise either the chitosan 0.6%- alginate 1.2% or the alginate 1.2% solution through a syringe into a 102 mM CaCl2 solution. Beads were analyzed histologically after 28 days. Interleukin (IL)-6 and -8, prostaglandin (PG) E2, matrix metalloproteinases (MMPs), hyaluronan and aggrecan were quantified directly in the culture supernatant by specific ELISA and nitric oxide (NO) by using a colorimetric method based on the Griess reaction. Hematoxylin and eosin staining showed that chitosan was homogeneously distributed through the matrix and was in direct contact with chondrocytes. The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads. PGE2 and NO decreased also significantly but only during the first three days of culture. Hyaluronan and aggrecan production tended to increase in chitosan-alginate beads after 28 days of culture. Chitosan-alginate beads reduced the production of inflammatory and catabolic mediators by OA chondrocytes and tended to stimulate the synthesis of cartilage matrix components. These particular effects indicate that chitosan-alginate beads are an interesting scaffold for chondrocytes encapsulation before transplantation to repair cartilage defects. [less ▲]

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See detailOrco mediates olfactory behaviors and winged morph differentiation induced by alarm pheromone in the grain aphid, Sitobion avenae
Fan, Jia; Zhang, Yong; Francis, Frédéric ULg et al

in Insect Biochemistry and Molecular Biology (2015), 64

Olfaction is crucial for short distance host location and pheromone detection by insects. Complexes of olfactory receptors (ORs) are composed of odor-specific ORs and OR co-receptors (Orco). Orcos are ... [more ▼]

Olfaction is crucial for short distance host location and pheromone detection by insects. Complexes of olfactory receptors (ORs) are composed of odor-specific ORs and OR co-receptors (Orco). Orcos are widely co-expressed with odor-specific ORs and are conserved across insect taxa. A number of Orco orthologs have been studied to date, although none has been identified in cereal aphids. In this study, an Orco gene ortholog was cloned from the grain aphid, Sitobion avenae, and named “SaveOrco”; RNA interference (RNAi) reduced the expression of SaveOrco to 34.11% in aphids, resulting in weaker EAG (electroantennogram) responses to plant volatiles (Z-3-hexene-1-ol; methyl salicylate, MeSA) and aphid alarm pheromone (E-b-farnesene, EBF). Aphid wing differentiation induced by EBF was investigated in both RNAi treated and untreated aphids. EBF induced production of winged aphids in both pre-natal and postnatal periods in untreated aphids, but no such induction was observed in the RNAi-treated aphids. We conclude that SaveOrco is crucial for the aphid's response to pheromones and other volatiles, and is involved in wing differentiation triggered by EBF [less ▲]

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See detailAutomated production at the curie level of no-carrier-added 6-[18F]fluoro-L-dopa and 2-[18F]fluoro-L-tyrosine on a FASTlab synthesizer
Lemaire, Christian ULg; Libert, Lionel; Franci, Xavier et al

in Journal of Labelled Compounds (2015), 58

An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[18F]fluoro-L-dopa ([18F]FDOPA) and 2-[18F]fluoro-L-tyrosine ([18F]FTYR) on a GE FASTlab synthesizer in ... [more ▼]

An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[18F]fluoro-L-dopa ([18F]FDOPA) and 2-[18F]fluoro-L-tyrosine ([18F]FTYR) on a GE FASTlab synthesizer in conjunction with an additional high-performance liquid chromatography (HPLC) purification has been developed. A PTC (phase-transfer catalyst) strategy wasused to synthesize these two important radiopharmaceuticals. According to recent chemistry improvements, automationof the whole process was implemented in a commercially available GE FASTlab module, with slight hardware modificationusing single use cassettes and stand-alone HPLC. [18F]FDOPA and [18F]FTYR were produced in 36.3 ± 3.0 % (n = 8) and50.5 ± 2.7 % (n = 10) FASTlab radiochemical yield (decay corrected). The automated radiosynthesis on the FASTlab modulerequires about 52 min. Total synthesis time including HPLC purification and formulation was about 62 min. Enantiomericexcesses for these two aromatic amino acids were always >95 %, and the specific activity of was >740 GBq/μmol. Thisautomated synthesis provides high amount of [18F]FDOPA and [18F]FTYR (>37 GBq end of synthesis (EOS)). The process, fullyadaptable for reliable production across multiple PET sites, could be readily implemented into a clinical good manufacturingprocess (GMP) environment. [less ▲]

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See detailHow shattered flakes were used : Micro-wear analysis of quartz flake fragments
Knutsson, Helena; Knutsson, Kjel; Taipale, Noora ULg et al

in Journal of Archaeological Science: Reports (2015), 2

Prehistoric quartz assemblages have always posed a special problem for archaeologists. Due to its brittle nature, quartz is hard to understand within lithic classification systems that are based on ... [more ▼]

Prehistoric quartz assemblages have always posed a special problem for archaeologists. Due to its brittle nature, quartz is hard to understand within lithic classification systems that are based on formally varied flint assemblages. In this paper we explore ways to deal with this problem by applying two analytical methods, fracture analysis and use-wear analysis. A sample of 544 unmodified quartz flakes and flake fragments from Mesolithic and Neolithic sites in Sweden and Finland was analysed. It can be concluded that both whole and fragmented flakes were used as tools. Larger flakes and flake fragments were preferred as tool blanks and the type of use was correlated to variation in edge qualities rather than the formal characteristics of flakes. The results of this investigation suggest that making behavioural inferences from quartz assemblages with low formal variability requires the assemblages to be approached with a focus on functional types. [less ▲]

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See detailOn the use of the transmission disequilibrium test to detect pseudo-autosomal variants affecting traits with sex-limited expression
Elansary, Mahmoud ULg; Stinckens, Anneleen; Ahariz, Naïma ULg et al

in Animal Genetics (2015)

We herein describe the realization of a genome-wide association study for scrotal hernia and cryptorchidism in Norwegian and Belgian commercial pig populations. We have used the transmission ... [more ▼]

We herein describe the realization of a genome-wide association study for scrotal hernia and cryptorchidism in Norwegian and Belgian commercial pig populations. We have used the transmission disequilibrium test to avoid spurious associations due to population stratification. By doing so, we obtained genome-wide significant signals for both diseases with SNPs located in the pseudo-autosomal region in the vicinity of the pseudo-autosomal boundary. By further analyzing these signals, we demonstrate that the observed transmission disequilibria are artifactual. We determine that transmission bias at pseudo-autosomal markers will occur (i) when analyzing traits with sex-limited expression and (ii) when the allelic frequencies at the marker locus differ between X and Y chromosomes. We show that the bias is due to the fact that (i) sires will preferentially transmit the allele enriched on the Y (respectively X) chromosome to affected sons (respectively daughters) and (ii) dams will appear to preferentially transmit the allele enriched on the Y (respectively X) to affected sons (respectively daughters), as offspring inheriting the other allele are more likely to be non-informative. We define the conditions to mitigate these issues, namely by (i) extracting information from maternal meiosis only and (ii) ignoring trios for which sire and dam have the same heterozygous genotype. We show that by applying these rules to scrotal hernia and cryptorchidism, the pseudo-autosomal signals disappear, confirming their spurious nature. [less ▲]

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See detailAcetylene (C2H2) and hydrogen cyanide (HCN) from IASI satellite observations: global distributions, validation, and comparison with model
Duflot, V.; Wespes, C.; Clarisse, L. et al

in Atmospheric Chemistry & Physics Discussions (2015), 15(10), 14357--14401

We present global distributions of C2H2 and HCN total columns derived from the Infrared Atmospheric Sounding Interferometer (IASI). These distributions are obtained with a fast method allowing to retrieve ... [more ▼]

We present global distributions of C2H2 and HCN total columns derived from the Infrared Atmospheric Sounding Interferometer (IASI). These distributions are obtained with a fast method allowing to retrieve C2H2 abundance globally with a 5% precision and HCN abundance in the tropical (subtropical) belt with a 10% (30%) precision. IASI data are compared for validation purposes with ground-based Fourier Transform Infrared (FTIR) spectrometer measurements at four selected stations. We show that there is an overall agreement between the ground-based and space measurements. Global C2H2 and subtropical HCN abundances retrieved from IASI spectra show the expected seasonality linked to variations in the anthropogenic emissions and seasonal biomass burning activity, as well as exceptional events, and are in good agreement with previous spaceborne studies. IASI measurements are also compared to the distributions from the Model for Ozone and Related Chemical Tracers, version 4 (MOZART- 4). Seasonal cycles observed from satellite data are reasonably well reproduced by the model. However, the model seems to overestimate (underestimate) anthropogenic (biomass burning) emissions and a negative global mean bias of 1% (16 %) of the model relative to the satellite observations was found for C2H2 (HCN). [less ▲]

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See detailGold nanorods coated with mesoporous silica shell as drug delivery system for remote near infrared light-activated release and potential phototherapy
Liu, Ji; Detrembleur, Christophe ULg; De Pauw-Gillet, Marie-Claire ULg et al

in Small (Weinheim an der Bergstrasse, Germany) (2015), 11(19), 2323-2332

In this study, we report the synthesis of a nanoscaled drug delivery system, which is composed of a gold nanorod-like core and a mesoporous silica shell (GNR@MSNP) and partially uploaded with phase ... [more ▼]

In this study, we report the synthesis of a nanoscaled drug delivery system, which is composed of a gold nanorod-like core and a mesoporous silica shell (GNR@MSNP) and partially uploaded with phase-changing molecules (1-tetradecanol, TD, Tm 39 degrees C) as gatekeepers, as well as its ability to regulate the release of doxorubicin (DOX). Indeed, a nearly zero premature release is evidenced at physiological temperature (37 degrees C), whereas the DOX release is efficiently achieved at higher temperature not only upon external heating, but also via internal heating generated by the GNR core under near infrared irradiation. When tagged with folate moieties, GNR@MSNPs target specifically to KB cells, which are known to overexpress the folate receptors. Such a precise control over drug release, combining with the photothermal effect of GNR cores, provides promising opportunity for localized synergistic photothermal ablation and chemotherapy. Moreover, the performance in killing the targeted cancer cells is more efficient compared with the single phototherapeutic modality of GNR@MSNPs. This versatile combination of local heating, phototherapeutics, chemotherapeutics and gating components opens up the possibilities for designing multifunctional drug delivery systems. [less ▲]

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See detailCombined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms
Gérard, Céline ULg; Mestdagt, Mélanie; Tskitishvili, Ekaterine ULg et al

in Oncotarget (2015)

Increased risk of breast cancer is a critical side effect associated with the use of a menopausal hormone therapy (MHT). Estetrol (E4) is a natural estrogen produced by the human fetal liver and is a ... [more ▼]

Increased risk of breast cancer is a critical side effect associated with the use of a menopausal hormone therapy (MHT). Estetrol (E4) is a natural estrogen produced by the human fetal liver and is a promising compound for clinical use in MHT. However, its impact on breast cancer is controversial and poorly defined. In this preclinical study, we show that E4 acts as a weak estrogen by stimulating the growth of hormone-dependent breast cancer only at concentrations exceeding menopausal therapeutic needs. E4 presents also an antitumor activity by decreasing the strong proliferative effect of estradiol (E2). While estrogen receptor alpha (ERα) is the predominant receptor mediating its effects, the dual weak-estrogenic/anti-estrogenic feature of E4 results from differential signaling pathways activation. Both nuclear and rapid extra-nuclear signaling pathway are necessary for a complete estrogenic effect of E4. However, the antitumor action of E4 is not due to a capacity to antagonize E2-induced nuclear activity. Altogether, our results highlight that E4 has a limited impact on breast cancer and may offer a safe therapeutic window for the treatment of menopausal symptoms. [less ▲]

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See detailPrésentation
Dozo, Björn-Olav ULg; Glinoer, Anthony

in Textyles : Revue des Lettres Belges de Langue Française (2015), 46

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See detailInfluence of substrate nature and β-lactoglobulin on cleanability after soiling by suspension spraying and drying
Toure, Yetioman ULg; Sindic, Marianne ULg; Dupont-Gillain, C. Christine et al

in Chemical Engineering Science (2015), 134

Glass and stainless steel (StSteel, AISI304-2R), previously cleaned with ethanol (-Eth) or with ethanol and UV–Ozone treatment (-UVO), were soiled with quartz suspensions in water and in a β-lactoglobulin ... [more ▼]

Glass and stainless steel (StSteel, AISI304-2R), previously cleaned with ethanol (-Eth) or with ethanol and UV–Ozone treatment (-UVO), were soiled with quartz suspensions in water and in a β-lactoglobulin (β-LGB) solution, and dried. The cleanability (ease of quartz particle detachment) in water was evaluated using a radial-flow cell. The soiling suspension containing β-LGB was used as such or after heating for 4h at 75°C, which provoked coagulation of about 75% of β-LGB. The substrate–solution interfaces were characterized by X-ray photoelectron spectroscopy (XPS) analysis of conditioned substrates and by contact angle measurements. The substrate surfaces are covered by a layer of organic contaminants which are not removed by pre-cleaning or are adsorbed from the surroundings. The presence of β-LGB in the soiling suspension leads to protein adsorption, but a significant amount of contaminants remains at the surface. For three of the substrates tested (Glass-Eth, Glass-UVO, StSteel-UVO) the increase of cleanability when the soiling suspension contained β-LGB may be explained by lower capillary forces acting upon drying. Capillary forces are proportional to the liquid surface tension and depend in a less important way on substrate contact angle. However the order of cleanability observed for the substrates soiled with a suspension of quartz particles in water (Glass-Eth≅Glass-UVO<StSteel-UVO<StSteel-Eth) and the influence of β-LGB on the cleanability of StSteel-Eth may not be explained only by computed capillary forces. The contact angle may exert a direct influence on droplet spreading and particle–substrate contact. The organic contaminants present on the surfaces, which are often neglected by supposing model solid surfaces, may have a significant influence on cleanability through physico-chemical processes which remain to be appreciated. [less ▲]

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See detailMeasurements on magnetized GdBCO pellets subjected to small transverse ac magnetic fields at very low frequency: Evidence for a slowdown of the magnetization decay
Fagnard, Jean-François ULg; Kirsch, Sébastien; Morita, Mitsuru et al

in Physica C: Superconductivity (2015), 512

Due to their ability to trap large magnetic inductions, superconducting bulk materials can be used as powerful permanent magnets. The permanent magnetization of such materials, however, can be ... [more ▼]

Due to their ability to trap large magnetic inductions, superconducting bulk materials can be used as powerful permanent magnets. The permanent magnetization of such materials, however, can be significantly affected by the application of several cycles of a transverse variable magnetic field. In this work, we study, at T = 77 K, the long term influence of transverse ac magnetic fields of small amplitudes (i.e. much smaller than the full penetration field) on the axial magnetization of a bulk single grain superconducting GdBCO pellet over a wide range of low frequencies (1 mHz–20 Hz). Thermocouples are placed against the pellet surface to probe possible self-heating of the material during the experiments. A high sensitivity cryogenic Hall probe is placed close to the surface to record the local magnetic induction normal to the surface. The results show first that, for a given number of applied triangular transverse cycles, higher values of dBapp/dt induce smaller magnetization decays. An important feature of practical interest is that, after a very large number of cycles which cause the loss of a substantial amount of magnetization (depending on the amplitude and the frequency of the field), the rate of the magnetization decay goes back to its initial value, corresponding to the relaxation of the superconducting currents due to flux creep only. In the amplitude and frequency range investigated, the thermocouples measurements and a 2D magneto-thermal modelling show no evidence of sufficient self-heating to affect the magnetization so that the effect of the transverse magnetic field cycles on the trapped magnetic moment is only attributed to a redistribution of superconducting currents in the volume of the sample and not to a thermal effect. [less ▲]

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See detailRheological behavior of β-Ti and NiTi powders produced by atomization for SLM production of open porous orthopedic implants
Yablokova, G.; Speirs, M.; Van Humbeeck, J. et al

in Powder Technology (2015)

The growing interest for Selective Laser Melting (SLM) in orthopedic implant manufacturing is accompanied by the introduction of novel Ti alloys, in particular β-Ti for their excellent corrosion ... [more ▼]

The growing interest for Selective Laser Melting (SLM) in orthopedic implant manufacturing is accompanied by the introduction of novel Ti alloys, in particular β-Ti for their excellent corrosion resistance as well as favorable combination of high mechanical strength, fatigue resistance and relatively low elastic modulus. As part of the SLM process for producing quality β-Ti parts powder flowability is essential to achieve uniform thickness of powder layers. In this work the flowability of different gas atomized β-Ti, including NiTi, powders has been studied. Their rheological properties were compared to those of commercially available plasma-atomized Ti–6Al–4V powder using a newly developed semi-automatic experimental set-up. Not only the particle size, shape and size distribution of the powders display a large influence on the powder flowability but also particle surface properties such as roughness, chemical composition and the presence of liquid on the surface of the particles. It was found that plasma or gas atomization production techniques for SLM powder have a considerable effect on the particle topography. Among the powders studied regarding SLM applicability only rheological properties of the fine size fraction (25–45 μm) of Ti–45Nb didn't conform to SLM processing requirements. To improve flowability of the Ti–45Nb powder itwas annealed both in air and argon atmosphere at 600 °C during 1 h, resulting in an improved rheological behavior suitable for SLM processing. [less ▲]

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See detailPolarization holography for vortex retarders recording: laboratory demonstration
Piron, Pierre ULg; Blain, Pascal ULg; Décultot, Marc ULg et al

in Applied Optics (2015), 54(15), 4765--4770

This paper will present a prototype of the first set of vortex retarders made of liquid crystal polymers recorded by polarization holography. Vortex retarders are birefringent plates characterized by a ... [more ▼]

This paper will present a prototype of the first set of vortex retarders made of liquid crystal polymers recorded by polarization holography. Vortex retarders are birefringent plates characterized by a rotation of their fast axis. Liquid crystals possess birefringent properties and they are locally orientable. Their orientation is defined by the perpendicular to the local orientation of the recording field. Polarization holography is a purely optical recording method. It is based on the superimposition of coherent and differently polarized beams. It is used to shape the electric field pattern to enable the recording of vortex retarders. The paper details the mathematical model of the superimposition process. The recording setup is exposed; it is characterized by a nearly common path interferometer. Two sets of measurements allowing the prediction of the retarder’s features are presented and compared. Finally, the experimentally recorded retarder is shown, its characteristics are investigated and compared to the predicted ones. [less ▲]

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See detailThe utility of Google Scholar when searching geographical literature: comparison with three commercial bibliographic databases
Stirbu, Simona ULg; Thirion, Paul ULg; Schmitz, Serge ULg et al

in Journal of Academic Librarianship (2015), 41(3), 322-329

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science ... [more ▼]

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science (WoS) and FRANCIS (multidisciplinary databases) and GeoRef (specialized in geosciences). To ensure a valid comparison, identical bibliographic searches were applied using each of the four bibliographic tools. To exclude automatic variations of the ten keywords tested, they were placed between quotation marks and searched only in the “title” field of the respective search tools’ interfaces. The results were limited to bibliographic references published from 2005 to 2009. In order to assess the repeatability of the results, the exact same process was repeated monthly between November 2010 and July 2011. Initially the whole set of results was analyzed, after which the search results for two keywords (selected since they yielded a manageable number of results) were studied in more detail. The results indicate that GS search results show a large degree of overlap with those of the other databases but, moreover, yield numerous unique hits, which should be useful to researchers in both the fields of human and physical geography. GS leads the other tools widely on number of results, independently of keyword, subfield, year of publication, or time of search. [less ▲]

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See detailCortical reorganization in an astronaut's brain after long-duration spaceflight.
Demertzi, Athina ULg; Van Ombergen, Angelique; Tomilovskaya, Elena et al

in Brain Structure & Function (2015)

To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in ... [more ▼]

To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients. [less ▲]

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See detailFoamability and Foam Stability of Male and Female Date Palm Sap (Phoenix dactylifera L.) During the Collection Period
Makhlouf-gafsi, Ines; Mokni-ghribi, Abir; Bchir, Brahim et al

in Food Biophysics (2015)

This work aimed to study the influence of date palm sex on the surface properties of date palm sap (DPS) (Phoenix dactylifera L.) during the collection period. The behavior at the interface and foaming ... [more ▼]

This work aimed to study the influence of date palm sex on the surface properties of date palm sap (DPS) (Phoenix dactylifera L.) during the collection period. The behavior at the interface and foaming properties were evaluated via equilibrium surface tension (drop volume) and bubbling method, respectively. Unlike male sap, the female sap was unable to produce foam due to its low rate of adsorption, low average hydrophobicity values, and low bulk viscosity values throughout the collection period. For male sap, there are significant differences (p<0.05) on foaming properties throughout the collection period. In fact, the last 3 weeks of sap collection were characterized by a decrease pace of surface tension which explains the enhancement of both foam capacity and stability. The last week of collection period present the best foam power (0.9). To explain these differences, the interactions of several factors and their affects on foaming properties were examined. Results showed a positive correlation between foam capacity and average hydrophobicity values. In the other hand, foam stability exhibits a positive correlation with the increase of protein concentration and bulk viscosity. [less ▲]

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See detailAntimicrobial, antitumor and brine shrimp lethality assay of Ranunculus arvensis L. extracts
Muhammad Zeeshan Bhatti; Ali, Amjad ULg; Asma Saeed et al

in Pakistan Journal of Pharmaceutical Sciences (2015)

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE ... [more ▼]

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE), Methanol-Water Extract (MWE), Methanol-Acetone Extract (MAE), Methanol-Chloroform Extract (MCE) of Ranunculus arvensis (L.). Antitumor activity was evaluated with Agrobacterium tumefaciens (At10) induced potato disc assay. Cytotoxicity was evaluated with brine shrimp lethality assay. Antibacterial activity was evaluated with six bacterial strains including Escherichia coli, Enterobacter aerogenes, Bordetella bronchiseptica, Klebsiella pneumoniae, Micrococcus luteus and Streptococcus anginosus and antifungal screening was done against five fungal strains including Aspergillus niger, A. flavus, A. fumigates, Fusarium solani and Mucor species by using disc diffusion method. Best antitumor activity was obtained with ME and WE, having highest IC50 values 20.27±1.62 and 93.01±1.33μg/disc. Brine shrimp lethality assay showed LC50 values of AE, MAE and ME were obtained as 384.66±9.42μg/ml, 724.11±8.01μg/ml and 978.7±8.01μg/ml respectively. WE of R. arvensis revealed weak antimicrobial result against the tested microorganisms. On the other hand, the antifungal activity of the plant extracts was found to be insignificant. These findings demonstrate that extracts of R. arvensis possesses significant antitumor activity. Further extensive study is necessary to assess the therapeutic potential of the plant [less ▲]

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See detailLipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment
Brohée, Laura ULg; Demine, Stéphane; Willems, Jérôme ULg et al

in Oncotarget (2015), 6(13), 11264-11280

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the ... [more ▼]

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and as co-transcriptional regulators. Thus, they are able to regulate lipid homeostasis at several nodal points. Here, we show that lipin-1 is up-regulated in several cancer cell lines and overexpressed in 50 % of high grade prostate cancers. The proliferation of prostate and breast cancer cells, but not of non-tumorigenic cells, was repressed upon lipin-1 knock-down. Lipin-1 depletion also decreased cancer cell migration through RhoA activation. Lipin-1 silencing did not significantly affect global lipid synthesis but enhanced the cellular concentration of phosphatidic acid. In parallel, autophagy was induced while AKT and ribosomal protein S6 phosphorylation were repressed. We also observed a compensatory regulation between lipin-1 and lipin-2 and demonstrated that their co-silencing aggravates the phenotype induced by lipin-1 silencing alone. Most interestingly, lipin-1 depletion or lipins inhibition with propranolol sensitized cancer cells to rapamycin. These data indicate that lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy. [less ▲]

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See detailFuture climate and surface mass balance of Svalbard glaciers in an RCP8.5 climate scenario: a study with the regional climate model MAR forced by MIROC5
Lang, Charlotte ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

in Cryosphere (The) (2015), 9

We simulated the 21st century Svalbard SMB with the regional model MAR (RCP8.5 scenario). Melt is projected to increase gently up to 2050 and then dramatically increase, with a larger increase in the ... [more ▼]

We simulated the 21st century Svalbard SMB with the regional model MAR (RCP8.5 scenario). Melt is projected to increase gently up to 2050 and then dramatically increase, with a larger increase in the south of the archipelago. This difference is due to larger ice albedo decrease in the south causing larger increase of absorbed solar radiation. The ablation area is projected to disappear over the entire Svalbard by 2085. The SMB decrease compared to present is projected to contribute 7mm to SLR. [less ▲]

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See detailArmée européenne : quelle phase transitoire ?
Dumoulin, André ULg

in Europe Diplomatie & Défense (2015), (792), 3

Page Idées sur la nécessité de créer les conditions d'une Union européenne de sécurité et de défense (UESD) à partir de quelques Etats membres de l'UE

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See detailChitosan-coated electrospun nanofibers with antibacterial activity
Croisier, Florence ULg; Sibret, Pierre ULg; Dupont-Gillain, Christine C. et al

in Journal of Materials Chemistry B (2015), 3(17), 3508-2517

Charged nanofibers were prepared by electrospinning (ESP) poly(ε-caprolactone) with a copolymer bearing carboxylic acid functions. The presence of these functions allowed exposing some negative charges on ... [more ▼]

Charged nanofibers were prepared by electrospinning (ESP) poly(ε-caprolactone) with a copolymer bearing carboxylic acid functions. The presence of these functions allowed exposing some negative charges on the fiber surface, by dipping the fibers in a phosphate buffer. A layer of chitosan, a polycation in acidic medium, was then deposited on the nanofiber surface, thanks to electrostatic attraction. Fibers were characterized at each step of the process and the influence of the copolymer architecture on chitosan deposition was discussed. The antibacterial activity of the resulting fibers was finally assessed. [less ▲]

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See detailA fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae
Zune, Quentin ULg; Delepierre, Anissa ULg; Gofflot, Sebastien et al

in Applied Microbiology and Biotechnology (2015)

Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-state related physiological mechanisms. This work is based on the comparative analysis of classical ... [more ▼]

Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-state related physiological mechanisms. This work is based on the comparative analysis of classical submerged fermentation with a fungal biofilm reactor for the production of a Gla::GFP fusion protein by Aspergillus oryzae. The biofilm reactor comprises a metal structured packing allowing the attachment of the fungal biomass. Since the production of the target protein is under the control of the promoter glaB, specifically induced in solid-state fermentation, the biofilm mode of culture is expected to enhance the global productivity. Although production of the target protein was enhanced by using the biofilm mode of culture, we also found that fusion protein production is also significant when the submerged mode of culture is used. This result is related to high shear stress leading to biomass autolysis and leakage of intracellular fusion protein into the extracellular medium. Moreover, 2D-gel electrophoresis highlights the preservation of fusion protein integrity produced in biofilm conditions. Two fungal biofilm reactor designs were then investigated further, i.e. with full immersion of the packing or with medium recirculation on the packing, and the scale-up potentialities were evaluated. In this context, it has been shown that full immersion of the metal packing in the liquid medium during cultivation allows for a uniform colonization of the packing by the fungal biomass and leads to a better quality of the fusion protein. [less ▲]

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See detailMetabolomic analysis of the green microalga Chlamydomonasreinhardtii cultivated under day/night conditions
Willamme, Rémi ULg; Alsafra, Zouheir; Arumugam, Rameshkumar et al

in Journal of Biotechnology (2015)

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See detailInfluence of bottom currents on the sedimentary processes at the western tip of the Gulf of Corinth, Greece
Beckers, Arnaud ULg; Beck, Christian; Hubert, Aurelia ULg et al

in Marine Geology (2015)

We investigated the sedimentary processes that were active during the Holocene in the Gulf of Corinth, using high-resolution seismic reflection profiles and gravity cores. Seismic reflection data clearly ... [more ▼]

We investigated the sedimentary processes that were active during the Holocene in the Gulf of Corinth, using high-resolution seismic reflection profiles and gravity cores. Seismic reflection data clearly show the presence of shallow-water sediment drifts at the western end of the Gulf, close to the Rion Sill that links the gulf to the Ionian Sea. Short cores indicate that drifts are composed of homogenous bioturbated mud in their upper part. The drift deposits flank a wide central area where the sea floor is eroded and where pre-Holocene deposits locally outcrop. The sea floor morphology in this area is marked by furrows oriented in different directions and by a depression attributed to the action of bottom-currents. The magnetic fabric of sediment samples from the drift, shelves, sub-basins and from the basin floor show a significant anisotropy and a similar orientation of Kmax axes along core. The largest anisotropy (P = 1.043 ± 0.007) is observed in the drift and is interpreted as resulting from the action of bottom currents. The similar orientation of Kmax axes in the other cores, collected from areas East of the drifts, suggests that bottom currents also affect sediment deposition in the rest of the study area, even if seismic profiles and core analyses demonstrate that gravitational processes such as submarine landslides and turbidity currents exert the main control on sediment transport and deposition. Average Kmax axes for four cores were reoriented using the declination of the characteristic remanent magnetization. Kmax axes show variable orientations relatively to the slope of the sea floor, between along-slope and roughly parallel to the contour lines. [less ▲]

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See detailPhotometric identification of the periods of the first candidate extragalactic magnetic massive stars
Nazé, Yaël ULg; Walborn, Nolan R.; Morrell, Nidia et al

in Astronomy and Astrophysics (2015), 577

Galactic stars belonging to the Of?p category are all strongly magnetic objects exhibiting rotationally modulated spectral and photometric changes on timescales of weeks to years. Five candidate Of?p ... [more ▼]

Galactic stars belonging to the Of?p category are all strongly magnetic objects exhibiting rotationally modulated spectral and photometric changes on timescales of weeks to years. Five candidate Of?p stars in the Magellanic Clouds have been discovered, notably in the context of ongoing surveys of their massive star populations. Here we describe an investigation of their photometric behaviour, revealing significant variability in all studied objects on timescales of one week to more than four years, including clearly periodic variations for three of them. Their spectral characteristics along with these photometric changes provide further support for the hypothesis that these are strongly magnetized O stars, analogous to the Of?p stars in the Galaxy. [less ▲]

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See detailPerformance-Based Aid: Why it will probably not meet promises
Paul, Elisabeth ULg

in Development Policy Review (2015), 33(3),

Performance-based aid (PBA) is increasingly advocated as a way to improve development aid effectiveness through resolving incentive issues inherent in aid relationships. Some donors use PBA together with ... [more ▼]

Performance-based aid (PBA) is increasingly advocated as a way to improve development aid effectiveness through resolving incentive issues inherent in aid relationships. Some donors use PBA together with performance-based financing arrangements within partner countries. Expectations from PBA are high – yet, while its rationale may look appealing, it is grounded on a restrictive model and flawed when taking account of real-world context. A number of problems associated to PBA have already been advanced as jeopardising its success. More fundamentally, one may question the mere appropriateness of PBA to provide incentives all along the chain from recipient governments to those who are supposed to produce results. Thus believing that PBA can have a mechanistic trickle-down incentive effect seems an illusion. [less ▲]

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See detailLe droit européen de l’abus de position dominante en 2014
Petit, Nicolas ULg

in Contrats Concurrence Consommation (2015)

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See detailExpression of sexual ornaments in a polymorphic species: phenotypic variation in response to environmental risk
Winandy, Laurane ULg; Denoël, Mathieu ULg

in Journal of Evolutionary Biology (2015), 28(5), 1049-1056

Secondary sexual traits may evolve under the antagonistic context of sexual and natural selection. In some polymorphic species, these traits are only expressed during the breeding period and are ... [more ▼]

Secondary sexual traits may evolve under the antagonistic context of sexual and natural selection. In some polymorphic species, these traits are only expressed during the breeding period and are differently expressed in alternative phenotypes. However, it is unknown whether such phenotypes exhibit phenotypic plasticity of seasonal ornamentations in response to environmental pressures such as in the presence of fish (predation risk). This is an important question to understand the evolution of polyphenisms. We used facultative paedomorphosis in newts as a model system because it involves the coexistence of paedomorphs that retain gills in the adult stage with metamorphs that have undergone metamorphosis, but also because newts exhibit seasonal sexual traits. Our aim was therefore to determine the influence of fish on the development of seasonal ornamentation in the two phenotypes of the palmate newt (Lissotriton helveticus). During the entire newt breeding period, we assessed the importance of phenotype and fish presence with an information-theoretic approach. Our results showed that paedomorphs presented much less developed ornamentation than metamorphs and those ornamentations varied over time. Fish inhibited the development of sexual traits but differently between phenotypes: in contrast to metamorphs, paedomorphs lack the phenotypic plasticity of sexual traits to environmental risk. This study points out that internal and external parameters act in complex ways in the expression of seasonal sexual ornamentations and that similar environmental pressure can induce a contrasted evolution in alternative phenotypes. [less ▲]

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See detailA comparison of within-season yield prediction algorithms based on crop model behaviour analysis
Dumont, Benjamin ULg; Basso, Bruno; Leemans, Vincent ULg et al

in Agricultural and Forest Meteorology (2015), 204

The development of methodologies for predicting crop yield, in real-time and in response to different agro-climatic conditions, could help to improve the farm management decision process by providing an ... [more ▼]

The development of methodologies for predicting crop yield, in real-time and in response to different agro-climatic conditions, could help to improve the farm management decision process by providing an analysis of expected yields in relation to the costs of investment in particular practices. Based on the use of crop models, this paper compares the ability of two methodologies to predict wheat yield (Triticum aestivum L.), one based on stochastically generated climatic data and the other on mean climate data. It was shown that the numerical experimental yield distribution could be considered as a log-normal distribution. This function is representative of the overall model behaviour. The lack of statistical differences between the numerical realisations and the logistic curve showed in turn that the Generalised Central Limit Theorem (GCLT) was applicable to our case study. In addition, the predictions obtained using both climatic inputs were found to be similar at the inter and intra-annual time-steps, with the root mean square and normalised deviation values below an acceptable level of 10% in 90% of the climatic situations. The predictive observed lead-times were also similar for both approaches. Given (i) the mathematical formulation of crop models, (ii) the applicability of the CLT and GLTC to the climatic inputs and model outputs, respectively, and (iii) the equivalence of the predictive abilities, it could be concluded that the two methodologies were equally valid in terms of yield prediction. These observations indicated that the Convergence in Law Theorem was applicable in this case study. For purely predictive purposes, the findings favoured an algorithm based on a mean climate approach, which needed far less time (by 300-fold) to run and converge on same predictive lead time than the stochastic approach. [less ▲]

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See detailOlympic stadiums and Cultural heritage: on the nature and status of heritage values in large sport facilities.
Kiuri, Miranda; Teller, Jacques ULg

in International Journal of the History of Sport (2015)

This paper investigates Olympic stadium heritage values and their cultural significance. It outlines the main challenges in stadium conservation through the interplay between bequest and use values. A ... [more ▼]

This paper investigates Olympic stadium heritage values and their cultural significance. It outlines the main challenges in stadium conservation through the interplay between bequest and use values. A value analysis of listed Olympic stadiums reveals that these are characterized by a specific heritage profile, related to the uniqueness and singularity of the buildings, of the landscape and of the sporting event. The history of architecture and sport are clearly interwoven in these places, as Olympic stadiums appear as testimonies of the evolution of sport and its status for past and present societies. Such an interpretation of Olympic stadium heritage could allow a better Olympic and sporting heritage evaluation and conservation, especially if the ensemble of existing Olympic stadiums was considered as a World Heritage network. [less ▲]

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See detailEmbedding Open Science in Doctoral Education at the University of Liege
Halleux, Isabelle ULg

in Doctoral Education Bulletin (2015)

This article is part of special issue on Open Research and Open education for early stage researchers. It presents good practices and main achievements in innovative and open Science doctoral training at ... [more ▼]

This article is part of special issue on Open Research and Open education for early stage researchers. It presents good practices and main achievements in innovative and open Science doctoral training at Ulg [less ▲]

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See detailTendinopathies and platelet-rich plasma (PRP): from pre-clinical experiments to therapeutic use
KAUX, Jean-François ULg; Drion, Pierre ULg; Croisier, Jean-Louis ULg et al

in Journal of Stem Cell & Regenerative Medicine (2015), 11(1), 7-17

Objectives: The restorative properties of platelets, through the local release of growth factors, are used in various medical areas. This article reviews fundamental and clinical research relating to ... [more ▼]

Objectives: The restorative properties of platelets, through the local release of growth factors, are used in various medical areas. This article reviews fundamental and clinical research relating to platelet-rich plasma applied to tendinous lesions. Materials and method: Articles in French and English, published between 1 January 2012 and 31 December 2014 dealing with PRP and tendons were searched for using the Medline and Scopus data bases. Results: Forty-seven articles were identified which addressed pre-clinical and clinical studies: 27 relating to in vitro and in vivo animal studies and 20 relating to human studies. Of these, five addressed lateral epicondylitis, two addressed rotator cuff tendinopathies, ten dealt with patellar tendinopathies and three looked at Achilles tendinopathies. Conclusions: The majority of pre-clinical studies show that PRP stimulates the tendon's healing process. However, clinical series remain more controversial and level 1, controlled, randomised studies are still needed. [less ▲]

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See detailModes de rémunération des médecins généralistes : quelles conséquences ?
Saint-Lary, Olivier; Franc, Carine; Raginel, Thibaud et al

in Exercer (2015), 119

Introduction. The health reform law crystallizes the tensions between the different health system players. Besides the specific issue of third-party payment, which will be addressed in an upcoming article ... [more ▼]

Introduction. The health reform law crystallizes the tensions between the different health system players. Besides the specific issue of third-party payment, which will be addressed in an upcoming article, some professional organizations wish to strengthen fee for servicies while others call for more mixed forms of remuneration. Many economic analyses were conducted to study the benefits and limits of each mode of physician compensation. This article offers a synthesis of the literature about these modes: fee for service, capitation, payment performance and wage labor. Method. Collaborative literature analysis between doctors and health economist. The databases searched were MEDLINE, the Cochrane Library and CAIRN. Results. Each mode has specific benefits and limits for the financer, the physicians and the patients. Fee for services increases physician productivity but may increases health spending. Capitation and salary decrease care supply but might help to control health spending and to develop preventive activities. The effectiveness of pay for performance is now being questioned. The current trend is to promote mixed forms of remuneration, hoping to combine the advantages and limit the share of defects of each modality. The complexity of such systems makes it difficult to compare from one country to another. Discussion. The choice of a mode by the financer must take into account both the possible combinations of different payment methods and the developments or societal aspirations to meet population health needs. [less ▲]

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See detailCorporate board attributes and conditional accounting conservatism: Evidence from French firms
Boussaid, Nabila ULg; Sougné, Danielle ULg; Hamza, Taher

in Journal of Applied Business Research (2015), Vol 31, No 3 (2015)

We investigate the relationship between corporate board of directors’ attributes and conditional accounting conservatism in the French context. Using a pooled regression model over the period 2009-2012 ... [more ▼]

We investigate the relationship between corporate board of directors’ attributes and conditional accounting conservatism in the French context. Using a pooled regression model over the period 2009-2012, our empirical results can be summarized as follows. First, greater board activity encourages more conservative reporting in financial statements. Second, larger board size diminishes conditional accounting conservatism. Lastly, there is a positive association between gender diversity and accounting conservatism. As a robustness test, we use alternative measures of accounting conservatism, namely time series and accrual-based measures in addition to asymmetric timeliness of earnings. Our findings suggest that boards of directors’ attributes are an important factor in determining the financial reporting quality of French firms. [less ▲]

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See detailDynamical Flavor Origin of ZN Symmetries
Aristizabal Sierra, Diego ULg; Vicente, Avelino ULg; Fong, Sheng et al

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2015), 91(9),

Discrete Abelian symmetries (ZN) are a common “artifact” of beyond the standard model physics models. They provide different avenues for constructing consistent scenarios for lepton and quark mixing ... [more ▼]

Discrete Abelian symmetries (ZN) are a common “artifact” of beyond the standard model physics models. They provide different avenues for constructing consistent scenarios for lepton and quark mixing patterns, radiative neutrino mass generation as well as dark matter stabilization. We argue that these symmetries can arise from the spontaneous breaking of the Abelian U(1) factors contained in the global flavor symmetry transformations of the gauge-invariant kinetic Lagrangian. This will be the case provided the ultraviolet completion responsible for the Yukawa structure involves scalar fields carrying nontrivial U(1) charges. Guided by minimality criteria, we demonstrate the viability of this approach with two examples: first, we derive the “scotogenic” model Lagrangian, and second, we construct a setup where the spontaneous symmetry-breaking pattern leads to a Z3 symmetry which enables dark matter stability as well as neutrino mass generation at the two-loop order. This generic approach can be used to derive many other models, with residual ZN or ZN1×⋯×ZNk symmetries, establishing an intriguing link between flavor symmetries, neutrino masses and dark matter. [less ▲]

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See detailA spectroscopic investigation of the O-type star population in four Cygnus OB associations. II. Determination of the fundamental parameters
Mahy, Laurent ULg; Rauw, Grégor ULg; De Becker, Michaël ULg et al

in Astronomy and Astrophysics (2015), 577

Aims: Having established the binary status of nineteen O-type stars located in four Cygnus OB associations, we now determine their fundamental parameters to constrain their properties and their ... [more ▼]

Aims: Having established the binary status of nineteen O-type stars located in four Cygnus OB associations, we now determine their fundamental parameters to constrain their properties and their evolutionary status. We also investigate their surface nitrogen abundances, which we compare with other results from the literature obtained for galactic O-type stars. Methods: Using optical spectra collected for each object in our sample and some UV data from the archives, we apply the CMFGEN atmosphere code to determine their main properties. For the binary systems, we have disentangled the components to obtain their individual spectra and investigate them as if they were single stars. Results: We find that the distances of several presumably single O-type stars seem poorly constrained because their luminosities are not in agreement with the "standard" luminosities of stars with similar spectral types. The ages of these O-type stars are all less than 7 Myr. Therefore, the ages of these stars agree with those, quoted in the literature, of the four associations, except for Cyg OB8 for which the stars seem older than the association itself. However, we point out that the distance of certain stars is debatable relative to values found in the literature. The N content of these stars put in perspective with N contents of several other galactic O-type stars seems to draw the same five groups as found in the "Hunter" diagram for the O and B-type stars in the LMC even though their locations are obviously different. We determine mass-loss rates for several objects from the Halpha line and UV spectra. Finally, we confirm the "mass discrepancy" especially for O stars with masses smaller than 30 Msun;. [less ▲]

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See detailSynedrella nodiflora (L.) Gaertn : a review on its phytochemical screening and uses in animal husbandry and medicine
Adjibode, A.G.; Tougan, U.P.; Youssao, A.K.I. et al

in International Journal of Advanced Scientific and Technical Research (2015), 3

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See detailInterrompre ou poursuivre la grossesse à l’adolescence: facteurs de risque psychosociaux.
GRECO, Antonia ULg; REGGERS, Jean; Glowacz, Fabienne ULg

in Neuropsychiatrie de l'Enfance et de l'Adolescence (2015)

précocesAbstractIntroduction. – Teenage pregnancy arouses lots of questions and remains a worldwide social and public health problem. This phenomenon isproblematic because it is often associated with ... [more ▼]

précocesAbstractIntroduction. – Teenage pregnancy arouses lots of questions and remains a worldwide social and public health problem. This phenomenon isproblematic because it is often associated with socio-economic, family and psychological difficulties.Objective. – Our study aims to identify the individual and environmental factors that influence the teenager’s decision whether to keep her child ornot.Method. – A sample of fourteen girls between 16 and 21 years old was recruited who had been or were pregnant. The girls were divided into2 groups: seven who decided to continue with their pregnancy and seven others who decided to have an abortion. This group was compared to girlswho had never been pregnant (n = 18). An interview was carried out and structured questionnaires were administered in order to evaluate individualand environmental characteristics as the age of menarche and the first sexual intercourse, the emotional and sexual education, the social and family support, the socio-cultural background and the socio-economic environment. Different other dimensions were analyzed: individual characteristics(Temperament and Character Inventory Junior, Impulsive Behaviour Scale, Coopersmith Self-Esteem Inventory) and family characteristics (AdverseChildhood Experiences) such as childhood family strengths and adverse childhood experiences.Results and conclusions. – Our study findings showed that a precarious socio-economic environment, a lack of support and affection in thefamily, emotional deprivations, a restricted social network, low self-esteem and school disinvestments would effectively predict the continuationof a pregnancy. Childhood family strengths seem to be strongly protective against early sexual intercourse, adolescent pregnancy and long-termpsychosocial consequences. On the other hand, no particular personality feature was demonstrated. Individual characteristics would thus have lessimpact on premature pregnancies than environmental characteristics. Prevention programs must stretch beyond the use of contraception, i.e. tendtoward an intervention for psycho-socially and socio-economically at risk families, so as to support them in their educational and affective rolewith their children. Psychological help could also be brought to young girls who have had experiences of maltreatment, to favour self-esteem andraise their awareness of the consequences of sexual risk behaviour. Finally, there should be specific help for the girls during the decision-makingperiod. Counselling during this period should be attentive to the resources and the motivations of the adolescent and to the circumstances of the pregnancy. [less ▲]

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See detailTaming uncertainty: Towards a new governance approach for nuclear waste management in Belgium
Parotte, Céline ULg; Delvenne, Pierre ULg

in Technology Analysis & Strategic Management (2015)

We focus on the new governance practices in Belgian nuclear waste management from its ‘participatory turn’ in the late 1990s. Rather than praising (or rejecting) participation versus expert analysis, we ... [more ▼]

We focus on the new governance practices in Belgian nuclear waste management from its ‘participatory turn’ in the late 1990s. Rather than praising (or rejecting) participation versus expert analysis, we make use of a theoretical and analytical framework in which the relevant dynamics for the analysis are ‘opening up’ and ‘closing down’ technological appraisals and commitments. Even though nuclear waste management agencies often plead for an integrative approach between expert analysis and stakeholder participation, in practice both exercises are often kept separate. We address this separation and its consequences and we find that societal concerns remain subsumed in the technical options that have long been favoured by the Belgian agency. This article encourages scholars, waste managers and decision-makers to scrutinise the moments and situations in which opening up would be desirable, and when, by contrast, it would be better to close down options in nuclear waste management. [less ▲]

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See detailFactors controlling Si export from soils: A soil column approach
Ronchi, Benedicta; Barao, Lucia; Clymans, Wim et al

in Catena (2015), 133

The release of dissolved silicon (DSi) from A and B horizons was investigated with leaching tests on unsaturated columns. As forest A horizons have larger biogenic Si (BSi) pools than arable lands, we ... [more ▼]

The release of dissolved silicon (DSi) from A and B horizons was investigated with leaching tests on unsaturated columns. As forest A horizons have larger biogenic Si (BSi) pools than arable lands, we compared the Si release from a forest and a cropland from the same geographical region developed on a Luvisol in Belgium and a Cambisol in Sweden. The A horizons released a quickly dissolving Si fraction in contrast to the B horizons, which did contain no or only little amounts of BSi and released lower Si concentrations. Our experiments show that Si export from forest soils is high because of the presence of a large reservoir of soluble BSi as well as due to the acidity of the soil (pH<4). Leaching at two different water fluxes revealed that export in forest soils was transport controlled while cropland soils were in equilibrium. [less ▲]

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See detailDPSC colonization of functionalized 3D textiles
Ortiz, Mariné; Rosales-Ibáñez, Raúl; de J Pozos-Guillén, Amaury et al

in Journal of Tissue Engineering and Regenerative Medicine (2015)

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See detailParathyroid carcinoma : Challenges in diagnosis and treatment
BETEA, Daniela ULg; Potorac, Iulia ULg; Beckers, Albert ULg

in Annales d'Endocrinologie (2015), 76

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See detailThe Kambarata 2 blast-fill dam, Kyrgyz Republic: blast event, geophysical monitoring and dam structure modelling
Havenith, Hans-Balder ULg; Torgoev, Isakbek; Torgoev, Almazbek ULg et al

in Geoenvironmental Disasters (2015), 2(1), 1-15

Abstract Background The blast-and earth-fill dam of the Kambarata 2 hydropower station is situated in the seismically active Central Tien Shan region of the Kyrgyz Republic. More than 70% of the dam ... [more ▼]

Abstract Background The blast-and earth-fill dam of the Kambarata 2 hydropower station is situated in the seismically active Central Tien Shan region of the Kyrgyz Republic. More than 70% of the dam volume was produced during a blast event on December 22, 2009. In 2010– 2011, dam construction was completed after earth filling on top of the blasted material and installing concrete and clay screens together with bentonite grouts. A geophysical survey had been completed in 2012–2013, mainly to monitor the resistivities inside the dam. ... [less ▲]

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See detailLinear and propeller-like fluoro-isoindigo based donor–acceptor small molecules for organic solar cells
Ouhib, Farid ULg; Tomassetti, Mirco ULg; Dierckx, Wauter et al

in Organic Electronics (2015), 20

Two donor–acceptor type fluoro-isoindigo based small molecule semiconductors are syn- thesized and their optical, electrochemical, thermal, and charge transport properties are investigated. The two ... [more ▼]

Two donor–acceptor type fluoro-isoindigo based small molecule semiconductors are syn- thesized and their optical, electrochemical, thermal, and charge transport properties are investigated. The two molecular chromophores differ by their architecture, linear (M1) vs propeller-like (M2). Both molecules present a broad absorption in the visible range and a low optical HOMO–LUMO gap (?1.6 eV). AFM images of solution-processed thin films show that the trigonal molecule M2 forms highly oriented fibrils after a few seconds of solvent vapor annealing. The materials are evaluated as electron donor components in bulk heterojunction organic solar cells using PC61BM as the electron acceptor. The devices based on the propeller-like molecule M2 exhibit a high open-circuit voltage (around 1.0 V) and a power conversion efficiency of 2.23%. [less ▲]

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See detailValid inequalities for the single arc design problem with set-ups
Agra, Agostinho; Doostmohammadi, Mahdi; Louveaux, Quentin ULg

in Discrete Optimization (2015), 16

We consider a mixed integer set which generalizes two well-known sets: the single node fixed- charge network set and the single arc design set. Such set arises as a relaxation of feasible sets of general ... [more ▼]

We consider a mixed integer set which generalizes two well-known sets: the single node fixed- charge network set and the single arc design set. Such set arises as a relaxation of feasible sets of general mixed integer problems such as lot-sizing and network design problems. We derive several families of valid inequalities that, in particular, generalize the arc resid- ual capacity inequalities and the flow cover inequalities. For the constant capacitated case we provide an extended compact formulation and give a partial description of the convex hull in the original space which is exact under a certain condition. By lifting some basic inequalities we provide some insight on the difficulty of obtaining such a full polyhedral description for the constant capacitated case. Preliminary computational results are presented. [less ▲]

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See detailLes réseaux lettrés du diplomate-écrivain Marcel-Henri Jaspar dans les années 1960. De la raison de Renan à l’ésotérisme de De Becker
Genin, Vincent ULg

in Textyles : Revue des Lettres Belges de Langue Française (2015), 46

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See detailOne good reason to speak of 'climate refugees'
Gemenne, François ULg

in Forced Migration Review (2015), 49

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See detailFast Chromatographic Method for Explosive Profiling
Stefanuto, Pierre-Hugues ULg; Perrault, Katelynn A.; Focant, Jean-François ULg et al

in Chromatography (2015), 2

Security control is becoming a major global issue in strategic locations, such as airports, official buildings, and transit stations. The agencies responsible for public security need powerful and ... [more ▼]

Security control is becoming a major global issue in strategic locations, such as airports, official buildings, and transit stations. The agencies responsible for public security need powerful and sensitive tools to detect warfare agents and explosives. Volatile signature detection is one of the fastest and easiest ways to achieve this task. However, explosive chemicals have low volatility making their detection challenging. In this research, we developed and evaluated fast chromatographic methods to improve the characterization of volatile signatures from explosives samples. The headspace of explosives was sampled with solid phase micro-extraction fiber (SPME). Following this step, classical gas chromatography (GC) and comprehensive two-dimensional GC (GC×GC) were used for analysis. A fast GC approach allows the elution temperature of each analyte to be decreased, resulting in decreased thermal degradation of sensitive compounds (e.g., nitro explosives). Using fast GC×GC, the limit of detection is further decreased based on the cryo-focusing effect of the modulator. Sampling of explosives and chromatographic separation were optimized, and the methods then applied to commercial explosives samples. Implementation of fast GC methods will be valuable in the future for defense and security forensics applications. [less ▲]

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See detailCardiac Biomarkers and Cycling Race
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Goffaux, Sébastien et al

in Journal of Sports Science & Medicine (2015), 14(2 (eCollection 2015 Jun)), 475-476

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See detailLa justice et les inégalités environnementales : concepts, méthodes et traduction politique aux États-Unis et en Europe
Lejeune, Zoé ULg

in Revue Française des Affaires Sociales (2015), n°1-2(2015/1), 51-78

Dans cet article, nous centrons notre réflexion sur la notion de justice environnementale, depuis son émergence en tant que champ d’investigation scientifique et d’activisme environnemental et social aux ... [more ▼]

Dans cet article, nous centrons notre réflexion sur la notion de justice environnementale, depuis son émergence en tant que champ d’investigation scientifique et d’activisme environnemental et social aux États-Unis dans les années 1980. Son intégration progressive au sein de politiques publiques environnementales ainsi que les résultats de cette mise à l’agenda public seront ensuite esquissés pour en montrer les évolutions et les limites. Ensuite, nous analysons son émergence dans le contexte européen pour montrer la plus-value que la justice environnementale peut apporter à la compréhension des rapports entre environnement et justice sociale. Les enjeux pour le contexte européen, en termes de recherche mais aussi de politiques publiques, sont abordés afin de mettre en lumière les apports potentiels de ce courant de recherche foisonnant aux États-Unis pour la réflexion sur le cumul d’inégalités socio-économiques et environnementales en Europe. [less ▲]

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See detailGene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis.
Liersch, Peter N.; Schwarz, Andreas; Sachweh, Joerg et al

in Future cardiology (2015), 11(3), 297-307

ABSTRACT Background: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified. METHODS: Six newborn lambs underwent pulmonary ... [more ▼]

ABSTRACT Background: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified. METHODS: Six newborn lambs underwent pulmonary arterial banding, seven sham operation. mRNA encoding for cytokines, growth factors and regulators of apoptosis was sequentially measured in myocardium and blood before and up to 12 weeks postoperatively. RESULTS: Experimental animals showed hypertrophy and fibrosis of the right ventricular myocardium, myocardial over-expression of CT-1-mRNA and higher blood concentrations of mRNA encoding for VEGF, TGF-beta, Bak and BcL-xL than controls, respectively. CONCLUSION: Neonatal pulmonary stenosis leads to myocardial hypertrophy that is associated with CT-1 gene expression and with activation of growth- and apoptosis pathways in blood cells. [less ▲]

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See detailLa robinsonnade d’anticipation. Sur une forme composite et ses péripéties
Stienon, Valérie ULg

in Nineteenth Century French Studies (2015), vol. 43(n°3-4), 250-266

In nineteenth-century French literature, adventure novels and futuristic fictions share various narrative and thematic features which generate an extensive set of “science fiction adventure” novels that ... [more ▼]

In nineteenth-century French literature, adventure novels and futuristic fictions share various narrative and thematic features which generate an extensive set of “science fiction adventure” novels that have not attracted much critical attention to date. However, such hybrid narratives lead us to reconsider a certain kind of futuristic fiction as it is defined as much by a geographical shift as by time travel. The particular and prolific case of the robinsonnade, regarded as a pivotal subgenre of adventure, facilitates highlighting such generic interferences. This paper examines four novels related either to utopian travel literature or to Jules Verne’s literary and editorial paradigm of the “voyages extraordinaires” in order to shed light on the dynamics framing the earliest forms of science fiction built on the topic of remote, flying, or spatial island. (In French) [less ▲]

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See detailL'affirmation de soi par le jeu de l'acteur : Un adjuvant utile pour la pratique de l'affirmation de soi ? Une étude évaluative pilote
Wagener, Aurélie ULg; Delvaux, Muriel ULg; Sarto, Danielle et al

in Revue Francophone de Clinique Comportementale et Cognitive (2015), XX(1), 6-14

En psychothérapie, les patients rapportent fréquemment des difficultés d’affirmation de soi, difficultés pour lesquelles les procédures thérapeutiques cognitives et comportementales ont démontré leur ... [more ▼]

En psychothérapie, les patients rapportent fréquemment des difficultés d’affirmation de soi, difficultés pour lesquelles les procédures thérapeutiques cognitives et comportementales ont démontré leur efficacité. L’objectif de cette recherche est de vérifier qu’une nouvelle combinaison de techniques (« jeu de l’acteur » et programme classique d’affirmation de soi) améliore le bien-être des patients. Ce programme est constitué de 10 séances alternativement animées par une actrice-metteuse en scène et par une psychologue-psychothérapeute. Les participants (N = 20) ont rempli des évaluations en pré et en post-test : questionnaire d’auto-efficacité sociale, échelles d’affirmation de soi, échelle d’estime de soi, échelle des aptitudes à la communication, échelles d’anxiété et de dépression. Des améliorations statistiquement significatives ont été mises en évidence pour chaque variable dépendante étudiée, sauf pour l’échelle de communication. La combinaison proposée permet bien une amélioration des différentes variables dépendantes mesurées même si les participants n’atteignent pas les scores d’un groupe contrôle exempt de difficultés d’affirmation de soi. [less ▲]

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See detailEstrogenic Evaluation and Organochlorine Identification in Blubber of North Sea Harbour Porpoise (Phocoena phocoena) Stranded on the North Sea Coast
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Jauniaux, Thierry ULg et al

in BioMed Research International (2015), 2015

Thirteen individual organochlorine compounds at 3 concentrations (80, 400, and 2000 ng/mL culture medium), as well as mixtures, were assayed for the estrogen receptor (ER) activation or inhibition, using ... [more ▼]

Thirteen individual organochlorine compounds at 3 concentrations (80, 400, and 2000 ng/mL culture medium), as well as mixtures, were assayed for the estrogen receptor (ER) activation or inhibition, using a luciferase reporter gene assay (RGA). None of the PCB 138, 153, or 180 or their mixture induced a response in the RGA. o,p'-DDT was the most potent xenoestrogen fromthe DDT group, inducing a response already at 80 ng/mL. From the HCH and HCB group, only 𝛽-HCH (at 400 and 2000 ng/mL) and 𝛿-HCH (at 2000 ng/mL) displayed estrogenic activities.These 13 organochlorines were determined by GC-MS in 12 samples of North Sea harbor porpoise blubber. The PCBs were the main contaminants. Within each group, PCB 153 (6.0 × 102∼4.2 × 104 𝜇g/kg), p,p'- DDE (5.1 × 102∼8.6 × 103 𝜇g/kg), and HCB (7.6 × 101∼1.5 × 103 𝜇g/kg) were the compounds found in highest concentrations.The hormonal activity of the porpoise blubber samples was also assayed in RGA, where two samples showed estrogenic activity, seven samples showed antiestrogenic activity, and one sample showed both estrogenic and antiestrogenic activity. Our results suggest that the 13 POPs measured by GC-MS in the samples cannot explain alone the estrogenicity of the extracts. [less ▲]

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See detailImproving adjuvant systems for polyclonal egg yolk antibody (IgY) production in laying hens in terms of productivity and animal welfare
Marcq, Christopher ULg; Marlier, Didier ULg; Beckers, Yves ULg

in Veterinary Immunology and Immunopathology (2015), 165(1-2), 54-63

The antibody production in the egg yolks of immunized laying hens is seen as a way of improving animal welfare compared with conventional production by mammals. Immunoglobulin Y (IgY) technology, however ... [more ▼]

The antibody production in the egg yolks of immunized laying hens is seen as a way of improving animal welfare compared with conventional production by mammals. Immunoglobulin Y (IgY) technology, however, has still to address welfare issues linked to the widespread use of an adjuvant in vaccines. Currently, Freund's adjuvants, complete (FCA) or incomplete (FIA), remain the standard. This study sought to evaluate various approaches used to enhance egg yolk antibody production in terms of both productivity and avian welfare. The outer membrane protein (OMP) of Salmonella Typhimurium was used as the prototype antigen. At 20 weeks of age, 56 ISA Brown hens, with specific-Salmonella-free status, were divided into seven groups (n = 8) and received an initial intramuscular immunization. Hens in the two negative control groups received phosphate buffered saline (PBS) or FIA alone. Hens in the other groups received 80 μg of Salmonella OMP emulsified with one of the following adjuvants: 200 μl of FIA alone (T1); 200 μl of FIA supplemented with 8 μg of C-phosphate-guanosine oligodeoxynucleotides (CpG-ODN) (T2); and 280 μl of Montanide ISA 70 VG (T4). Birds in the T3 group received the antigen in emulsion with FIA and were given the tested immunostimulatory component (l-carnitine) via their feed (100 mg/kg). A positive control group (PC) received FCA for the first and final immunizations and FIA for the other boosters. Immunization was repeated after 20, 46, 82 and 221 days. Eggs were collected regularly until 242 days after the first immunization and the anti-Salmonella Typhimurium activities in the yolk were determined by ELISA. After 242 days, the birds were euthanized and the injection sites were evaluated for gross and microscopic lesions. Among the tested immunostimulatory approaches, supplementation of FIA with CpG-ODN led to a significant and long-lasting enhancement of the specific antibody response. This treatment was even higher than the positive benchmark using FCA in the first immunization. The study results showed that a clinical examination of injection sites is insufficient for drawing conclusions about the local tolerance of vaccines. Tissue damage was noticeable in all treatment groups. The birds receiving the Montanide adjuvant, however, had fewer and less severe lesions. Given these limited side-effects, Montanide ISA 70 VG could provide the depot effect needed to ensure the immunomodulatory efficiency of CpG-ODN. The association of these two adjuvants could prove a promising alternative to Freund's adjuvants (FA). [less ▲]

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See detailNeural correlates of personal goal processing during episodic future thinking and mind-wandering: an ALE meta-analysis
Stawarczyk, David ULg; D'Argembeau, Arnaud ULg

in Human Brain Mapping (2015), 36(8), 2928-2947

The ability to imagine the future is a complex mental faculty that depends on an ensemble of cognitive processes supported by an extended set of brain regions. Our aim here was to shed light on one key ... [more ▼]

The ability to imagine the future is a complex mental faculty that depends on an ensemble of cognitive processes supported by an extended set of brain regions. Our aim here was to shed light on one key component of future thinking—personal goal processing—and to determine its neural correlates during both directed and spontaneous forms of thoughts. To address this question, we performed separate ALE meta-analyses of neuroimaging studies of episodic future thinking, mind-wandering, and personal goal processing, and then investigated the commonalities and differences in brain activity between these three domains. The results showed that the three domains activated a common set of brain regions within the default network and, most notably, the medial prefrontal cortex. This finding suggests that the medial prefrontal cortex mediates the processing of personal goals during both episodic future thinking and mind-wandering. Differences in activation were also observed, and notably regions supporting cognitive control processes (the dorsolateral prefrontal cortex) were recruited to a lesser extent during mind-wandering than experimentally directed future thinking, suggesting that different kinds of self-generated thoughts may recruit varying levels of attentional control abilities. [less ▲]

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See detailL'opposition et le délai de prescription de la peine
Michiels, Olivier ULg

in Revue de Droit Pénal et de Criminologie (2015)

L'opposition formée après le délai de prescription de la peine prononcée par défaut est, sauf cas de force majeure, irrecevable.

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See detailCochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling
Defourny, Jean; Mateo Sanchez, Susana ULg; Schoonaert, Lies et al

in Nature Communications (2015)

In mammals, cochlear sensory hair cells that are responsible for hearing are postmitotic and are not replaced after loss. One of the most promising strategies to regenerate hair cells is to identify and ... [more ▼]

In mammals, cochlear sensory hair cells that are responsible for hearing are postmitotic and are not replaced after loss. One of the most promising strategies to regenerate hair cells is to identify and inhibit the factors preventing the conversion of adjacent non-sensory supporting cells into hair cells. Here we demonstrate that mammalian hair cells can be directly generated from supporting cells by inhibition of ephrin-B2 signalling. Using either ephrin-B2 conditional knockout mice, shRNA-mediated gene silencing or soluble inhibitors, we found that downregulation of ephrin-B2 signalling at embryonic stages results in supporting cell translocation into hair cell layers and subsequent switch in cell identity from supporting cell to hair cell fate. As transdifferentiation is here a result of displacement across boundary, this original finding presents the interest that newly generated hair cells directly integrate either hair cell layer, then would be likely more rapidly able to fit into functional circuitry. [less ▲]

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See detailDevelopment and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies such as osteoarthritis.
Réeff, Jonathan; Oprenyeszk, Frédéric ULg; Franck, Thierry ULg et al

in International Journal of Pharmaceutics (2015), 490

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the ... [more ▼]

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the developed hydrolipidic gels were evaluated by measuring the production of ROS by polymorphonuclear leukocytes (PMNs). In addition, the biocompatibility and effectiveness of two selected gel candidates were evaluated in vivo by evaluating the benefit of a single intraarticular injection of these new treatments in a model of osteoarthritis in rabbits. The in vitro study demonstrated that the carrier F1 did not have a pro-oxidative effect and even protected PMNs against natural auto-activation, regardless of the incorporation of either clonidine chlorhydrate or betamethasone dipropionate. The in vivo study demonstrated that F1 and F1-BDP induced a loss of cartilage quality in comparison to the control and reference groups but that the lesions of cartilage observed were generally mild, with not much full-depth erosion. Moreover, no exacerbating inflammation was observed when considering the synovial membranes and the PGE2 and CRP levels. These results seemed to demonstrate that the sustained-release formulation based on GMO could be well-tolerated after intraarticular injection. Moreover, it could have the potential to prevent inflammatory conditions while sustaining drug activity locally over weeks. [less ▲]

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See detailInfluence of past and future climate changes on the distribution of three Southeast Asian murine rodents
Latinne, Alice ULg; Meynard, Christine; Herbreteau, Vincent et al

in Journal of Biogeography (2015)

Aim: We tested the influence of Pleistocene climatic fluctuations and the potential effect of future climate change on Southeast Asian small mammal distributions using two forest-dwelling (Leopoldamys ... [more ▼]

Aim: We tested the influence of Pleistocene climatic fluctuations and the potential effect of future climate change on Southeast Asian small mammal distributions using two forest-dwelling (Leopoldamys herberti and Leopoldamys sabanus) and one karst (Leopoldamys neilli) endemic rodent species as models. Location: Southeast Asia. Methods: We used presence–absence data of genetically identified individuals, bioclimatic variables and species distribution modelling techniques to predict potential distributions of the three studied species under current, past [Last Interglacial (LIG) and Last Glacial Maximum (LGM)] and future conditions. We applied a variety of modelling techniques and then used consensus techniques to draw up robust maps of potential distribution ranges at all stages. Results: According to our models, these three Leopoldamys species did not experience significant range contraction during the LGM. Our models revealed substantial range contraction during the LIG for L. herberti in northern Indochina, while its distribution expanded in southern Indochina. Evidence of a southward range expansion during that period was also obtained for L. neilli, whereas L. sabanus remained widely distributed in insular Southeast Asia but experienced a range contraction on the Thai-Malay Peninsula. The two future climate change scenarios used predicted that large climatically suitable areas would still be available in the future for the three species. Main conclusions: Our model predictions contradict the well-established hypothesis that Southeast Asian forest-dwelling species were confined to small refugia during the LGM. Moreover, our results suggest that some Southeast Asian taxa may have been distributed in their refugial state during the LIG rather than the LGM. This could be because of vegetation changes that may have occurred at that time as a result of the increased seasonality observed during the LIG. These Pleistocene refugia may have been localized in northern Indochina but our study also revealed that southern Indochina could provide major potential refugia. [less ▲]

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See detailA cautionary note on the impact of protocol changes for Genome-Wide Association SNP x SNP Interaction studies: an example on ankylosing spondylitis
Bessonov, Kyrylo ULg; Gusareva, Elena ULg; Van Steen, Kristel ULg

in Human Genetics (2015)

Genome-wide association interaction (GWAI) studies have increased in popularity. Yet to date, no standard protocol exists. In practice, any GWAI workflow involves making choices about quality control ... [more ▼]

Genome-wide association interaction (GWAI) studies have increased in popularity. Yet to date, no standard protocol exists. In practice, any GWAI workflow involves making choices about quality control strategy, SNP filtering, linkage disequilibrium (LD) pruning, analytic tool to model or to test for genetic interactions. Each of these can have an impact on the final epistasis findings and may affect their reproducibility in follow-up analyses. Choosing an analytic tool is not straightforward, as different such tools exist and current understanding about their performance is based on often very particular simulation settings. In the present study, we wish to create awareness for the impact of (minor) changes in a GWAI analysis protocol can have on final epistasis findings. In particular, we investigate the influence of marker selection and marker prioritization strategies, LD pruning and the choice of epistasis detection analytics on study results, giving rise to 8 GWAI protocols. Discussions are made in the context of the ankylosing spondylitis (AS) data obtained via the Wellcome Trust Case Control Consortium (WTCCC2). As expected, the largest impact on AS epistasis findings is caused by the choice of marker selection criterion, followed by marker coding and LD pruning. In MB-MDR, co-dominant coding of main effects is more robust to the effects of LD pruning than additive coding. We were able to reproduce previously reported epistasis involvement of HLA-B and ERAP1 in AS pathology. In addition, our results suggest involvement of MAGI3 and PARK2, responsible for cell adhesion and cellular trafficking. Gene Ontology (GO) biological function enrichment analysis across the 8 considered GWAI protocols also suggested that AS could be associated to the Central Nervous System (CNS) malfunctions, specifically, in nerve impulse propagation and in neurotransmitters metabolic processes. [less ▲]

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See detailVertical Distribution of Functional Potential and Active Microbial Communities in Meromictic Lake Kivu
İnceoğlu, Özgul; Llirós, Marc; Crowe, Sean A. et al

in Microbial Ecology (2015)

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See detailEffect of nanocrystalline structure on magnetocaloric effect in manganite composites (1/3)La0.7Ca0.3MnO3/(2/3)La0.8Sr0.2MnO3
Pękała, M; Pękała, K; Drozd, V et al

in Journal of Alloys & Compounds (2015), 629

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See detailTumor suppressive p53 signaling empowers metastatic inhibitor KLF17-dependent transcription to overcome tumorigenesis in non-small cell lung cancer.
Ali, Amjad ULg; Zeeshan Bhatti M; Saboor Shah A et al

in Journal of Biological Chemistry (2015)

Metastasis, which is controlled by concerted action of multiple genes, is a complex process, and is important cause of cancer death. KLF17 is a negative regulator of metastasis and epithelial-mesenchymal ... [more ▼]

Metastasis, which is controlled by concerted action of multiple genes, is a complex process, and is important cause of cancer death. KLF17 is a negative regulator of metastasis and epithelial-mesenchymal-transition (EMT) during cancer progression. However, the underlying molecular mechanism and biological relevance of KLF17 in cancer cells are poorly understood. Here, we show that tumor suppressor protein p53 plays an integral role to induce KLF17 expression in NSCLC. p53 is recruited to KLF17 promoter and results in the formation of p53-DNA complex. p53 enhances binding of p300, and favors histone acetylation on KLF17 promoter. Mechanistically, p53 physically interacts with KLF17 and thereby enhances anti-metastatic function of KLF17. p53 empowers KLF17 mediated EMT genes transcription via enhancing physical association of KLF17 to target gene promoters. Nutlin-3 recruits KLF17 to EMT target gene promoters and results in the formation of KLF17-DNA complex via p53-dependent pathway. p53 depletion abrogates DNA binding affinity of KLF17 to EMT target gene promoters. KLF17 is critical for p53 cellular activities in NSCLC. Importantly, KLF17 enhances p53 transcription to generate a novel positive feedback loop. KLF17 depletion accelerates lungs cancer cells growth in response to chemotherapy. Mechanistically, we found that KLF17 increases tumor suppressor genes p53, p21 and pRB expressions in NSCLC. Functionally, KLF17 required p53 to suppress cancer cell invasion and migration in NSCLC. In sum, our study highlights novel insight into anti-EMT affect of KLF17 via p53-dependent pathway in NSCLC, and KLF17 may be a new therapeutic target in NSCLC with p53 status. [less ▲]

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See detailREGg is critical for skin carcinogenesis by modulating the Wnt/b-catenin pathway
Lei Li; Yongyan Dang; Jishen Zhang et al

in nature communications (2015)

Here we report that mice deficient for the proteasome activator, REGg, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia ... [more ▼]

Here we report that mice deficient for the proteasome activator, REGg, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia and onset of papillomas compared with wild-type counterparts. Interestingly, a massive increase of REGg in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38). Blocking p38 MAPK activation prevents REGg elevation in HaCaT cells with TPA treatment. AP-1, the downstream effector of MAPK/p38, directly binds to the REGg promoter and activates its transcription in response to TPA stimulation. Furthermore, we find that REGg activates Wnt/b-catenin signalling by degrading GSK-3b in vitro and in cells, increasing levels of CyclinD1 and c-Myc, the downstream targets of b-catenin. Conversely, MAPK/p38 inactivation or REGg deletion prevents the increase of cyclinD1 and c-Myc by TPA. This study demonstrates that REGg acts in skin tumorigenesis mediating MAPK/p38 activation of the Wnt/b-catenin pathway. [less ▲]

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See detailDisrupting the wall accumulation of human sperm cells by artificial corrugation
Guidobaldi, H.A.; Jeyaram, Y.; Condat, C.A. et al

in Biomicrofluidics (2015), 9

Many self-propelled microorganisms are attracted to surfaces. This makes their dynamics in restricted geometries very di erent from that observed in the bulk. Swimming along walls is bene cial for ... [more ▼]

Many self-propelled microorganisms are attracted to surfaces. This makes their dynamics in restricted geometries very di erent from that observed in the bulk. Swimming along walls is bene cial for directing and sorting cells, but may be detrimental if homogeneous populations are desired, such as in counting microchambers. In this work, we characterize the motion of human sperm cells 60 um long, strongly confi ned to 25u m shallow chambers. We investigate the nature of the cell trajectories between the con fining surfaces and their accumulation near the borders. Observed cell trajectories are composed of a succession of quasi-circular and quasi-linear segments. This suggests that the cells follow a path of intermittent trappings near the top and bottom surfaces separated by stretches of quasi-free motion in between the two surfaces, as confi rmed by depth resolved confocal microscopy studies. We show that the introduction of arti cial petal-shaped corrugation in the lateral boundaries removes the tendency of cells to accumulate near the borders, an e ffect which we hypothesize may be valuable for micro fluidic applications in biomedicine. [less ▲]

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See detailEffects of enzymatic hydrolysis on conformational and functional properties of chickpea protein isolate
Ghribi, Abir Mokni; Maklouf Gafsi, Ines; Sila, Assaâd et al

in Food Chemistry (2015), 187

The impact of enzymatic hydrolysis by Alcalase on the conformational and functional properties of chickpea protein isolate (CPI) was investigated. The physicochemical, interfacial tension and surface ... [more ▼]

The impact of enzymatic hydrolysis by Alcalase on the conformational and functional properties of chickpea protein isolate (CPI) was investigated. The physicochemical, interfacial tension and surface characteristics of CPI and their hydrolysates (CPH) according to the degree of hydrolysis (DH) were also determined. These parameters were then related to the changes in the emulsification activity (EAI) and stability (ESI). The enzymatic hydrolysis was found to improve protein recovery and solubility, leading to a reduction in the molecular weight bands with a concomitant increase in the intensity and appearance of protein bands having apparent molecular mass below 20 kDa. The interfacial tension decreased from _66.5 mN m_1 for CPI to _59.1 mN m_1 for CPH. A similar trend was observed for the surface charge which declined from _27.55 mV to _16.4 mV for the CPI and CPH, respectively. These changes were found to have a detrimental effect on the EAI and ESI values. [less ▲]

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See detailDeformations of an elastic pipe submitted to gravity and internal fluid flow
Darbois-Texier, Baptiste ULg; Dorbolo, Stéphane ULg

in Journal Fluids and Structures (2015), 55

This article describes the deformation of an elastic pipe submitted to gravity and to an internal fluid flow. The pipe is clamped horizontally at one end and free at the other end. As the fluid velocity ... [more ▼]

This article describes the deformation of an elastic pipe submitted to gravity and to an internal fluid flow. The pipe is clamped horizontally at one end and free at the other end. As the fluid velocity increases, the shape changes from an elastic beam deflected by its own weight towards an horizontal posi- tion. The shape of the pipe is characterized experimentally and is compared with a theoretical model based on the Euler-Bernoulli approximation and the conservation of the fluid momentum. We study how the determination of the pipe deformation provides an estimation of the conveyed fluid flow. Finally, the vertical force produced by the conveyed fluid to lift off a mass is deduced. [less ▲]

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See detailEfficient one-pot synthesis of trans- Pt(II)(salicylaldimine)(4-picoline)Cl complexes: Effective agents for enhanced expression of p53 tumor suppressor genes
Faiz-Ur-Rahman; Ali, Amjad ULg; Rong Guo et al

in Dalton Transactions (2015)

A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available precursors. The structures of these complexes were ... [more ▼]

A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1H, 19F and 13C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dosedependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73. [less ▲]

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See detailZinc triggers a complex transcriptional and post-transcriptional regulation of the metal homeostasis gene FRD3 in Arabidopsis relatives
Charlier, Jean_Benoit; Polese, Catherine; Nouet, Cécile ULg et al

in Journal of Experimental Botany (2015)

In Arabidopsis thaliana, FRD3 (Ferric Chelate Reductase Defective 3) plays a central role in metal homeostasis. FRD3 is among a set of metal homeostasis genes that are constitutively highly expressed in ... [more ▼]

In Arabidopsis thaliana, FRD3 (Ferric Chelate Reductase Defective 3) plays a central role in metal homeostasis. FRD3 is among a set of metal homeostasis genes that are constitutively highly expressed in roots and shoots of Arabidopsis halleri, a zinc hyperaccumulating and hypertolerant species. Here, we examined the regulation of FRD3 by zinc in both species to shed light on the evolutionary processes underlying the evolution of hyperaccumulation in A. halleri. We combined gene expression studies with the use of GUS and GFP reporter constructs to compare the expression profile, transcriptional and post-transcriptional regulation of FRD3 in both species. The AtFRD3 and AhFRD3 genes display a conserved expression profile. In A. thaliana, alternative transcription initiation sites from two promoters determine transcript variants which are differentially regulated by zinc supply in roots and shoots to favour the most highly translated variant under zinc excess conditions. In A. halleri, a single transcript variant with higher transcript stability and enhanced translation has been maintained. The FRD3 gene thus undergoes complex transcriptional and post-transcriptional regulation in Arabidopsis relatives. Our study reveals that a diverse set of mechanisms underlie increased gene dosage in the A. halleri lineage and illustrates how an environmental challenge can alter gene regulation. [less ▲]

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See detailValidation of SCIAMACHY HDO/H2O measurements using the TCCON and NDACC-MUSICA networks
Scheepmaker, R. A.; Frankenberg, C.; Deutscher, N. M. et al

in Atmospheric Measurement Techniques (2015), 8(4), 1799-1818

Measurements of the atmospheric HDO/H2O ratio help us to better understand the hydrological cycle and improve models to correctly simulate tropospheric humidity and therefore climate change. We present an ... [more ▼]

Measurements of the atmospheric HDO/H2O ratio help us to better understand the hydrological cycle and improve models to correctly simulate tropospheric humidity and therefore climate change. We present an updated version of the column-averaged HDO/H2O ratio data set from the SCanning Imaging Absorption spectroMeter for Atmospheric CHartographY (SCIAMACHY). The data set is extended with 2 additional years, now covering 2003–2007, and is validated against co-located ground-based total column δD measurements from Fourier transform spectrometers (FTS) of the Total Carbon Column Observing Network (TCCON) and the Network for the Detection of Atmospheric Composition Change (NDACC, produced within the framework of the MUSICA project). Even though the time overlap among the available data is not yet ideal, we determined a mean negative bias in SCIAMACHY δD of −35 ± 30‰ compared to TCCON and −69 ± 15‰ compared to MUSICA (the uncertainty indicating the station-to-station standard deviation). The bias shows a latitudinal dependency, being largest (∼ −60 to −80‰) at the highest latitudes and smallest (∼ −20 to −30‰) at the lowest latitudes. We have tested the impact of an offset correction to the SCIAMACHY HDO and H2O columns. This correction leads to a humidity- and latitude-dependent shift in δD and an improvement of the bias by 27‰, although it does not lead to an improved correlation with the FTS measurements nor to a strong reduction of the latitudinal dependency of the bias. The correction might be an improvement for dry, high-altitude areas, such as the Tibetan Plateau and the Andes region. For these areas, however, validation is currently impossible due to a lack of ground stations. The mean standard deviation of single-sounding SCIAMACHY–FTS differences is ∼ 115‰, which is reduced by a factor ∼ 2 when we consider monthly means. When we relax the strict matching of individual measurements and focus on the mean seasonalities using all available FTS data, we find that the correlation coefficients between SCIAMACHY and the FTS networks improve from 0.2 to 0.7–0.8. Certain ground stations show a clear asymmetry in δD during the transition from the dry to the wet season and back, which is also detected by SCIAMACHY. This asymmetry points to a transition in the source region temperature or location of the water vapour and shows the added information that HDO/H2O measurements provide when used in combination with variations in humidity. [less ▲]

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See detailThalamic and extrathalamic mechanisms of consciousness after severe brain injury.
Lutkenhoff, Evan; Chiang, Jeffrey; TSHIBANDA, Luaba ULg et al

in Annals of Neurology (2015)

Abstract OBJECTIVE: What mechanisms underlie the loss and recovery of consciousness after severe brain injury? We sought to establish, in the largest cohort of patients with disorders of consciousness ... [more ▼]

Abstract OBJECTIVE: What mechanisms underlie the loss and recovery of consciousness after severe brain injury? We sought to establish, in the largest cohort of patients with disorders of consciousness (DOC) to date, the link between gold standard clinical measures of awareness and wakefulness, and specific patterns of local brain pathology-thereby possibly providing a mechanistic framework for patient diagnosis, prognosis, and treatment development. METHODS: Structural T1-weighted magnetic resonance images were collected, in a continuous sample of 143 severely brain-injured patients with DOC (and 96 volunteers), across 2 tertiary expert centers. Brain atrophy in subcortical regions (bilateral thalamus, basal ganglia, hippocampus, basal forebrain, and brainstem) was assessed across (1) healthy volunteers and patients, (2) clinical entities (eg, vegetative state, minimally conscious state), (3) clinical measures of consciousness (Coma Recovery Scale-Revised), and (4) injury etiology. RESULTS: Compared to volunteers, patients exhibited significant atrophy across all structures (p < 0.05, corrected). Strikingly, we found almost no significant differences across clinical entities. Nonetheless, the clinical measures of awareness and wakefulness upon which differential diagnosis rely were systematically associated with tissue atrophy within thalamic and basal ganglia nuclei, respectively; the basal forebrain was atrophied in proportion to patients' response to sensory stimulation. In addition, nontraumatic injuries exhibited more extensive thalamic atrophy. INTERPRETATION: These findings provide, for the first time, a grounding in pathology for gold standard behavior-based clinical measures of consciousness, and reframe our current models of DOC by stressing the different links tying thalamic mechanisms to willful behavior and extrathalamic mechanisms to behavioral (and electrocortical) arousal. Ann Neurol 2015. [less ▲]

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See detailDetermination of Zinc, Cadmium and Lead Bioavailability in Contaminated Soils at the Single-Cell Level by a Combination of Whole-Cell Biosensors and Flow Cytometry
Hurdebise, Quentin ULg; Tarayre, Cédric ULg; Fischer, Christophe ULg et al

in Sensors (2015)

Zinc, lead and cadmium are metallic trace elements (MTEs) that are widespread in the environment and tend to accumulate in soils because of their low mobility and non-degradability. The purpose of this ... [more ▼]

Zinc, lead and cadmium are metallic trace elements (MTEs) that are widespread in the environment and tend to accumulate in soils because of their low mobility and non-degradability. The purpose of this work is to evaluate the applicability of biosensors as tools able to provide data about the bioavailability of such MTEs in contaminated soils. Here, we tested the genetically-engineered strain Escherichia coli pPZntAgfp as a biosensor applicable to the detection of zinc, lead and cadmium by the biosynthesis of green fluorescent protein (GFP) accumulating inside the cells. Flow cytometry was used to investigate the fluorescence induced by the MTEs. A curvilinear response to zinc between 0 and 25 mg/L and another curvilinear response to cadmium between 0 and 1.5 mg/L were highlighted in liquid media, while lead did not produce exploitable results. The response relating to a Zn2+/Cd2+ ratio of 10 was further investigated. In these conditions, E. coli pPZntAgfp responded to cadmium only. Several contaminated soils with a Zn2+/Cd2+ ratio of 10 were analyzed with the biosensor, and the metallic concentrations were also measured by atomic absorption spectroscopy. Our results showed that E. coli pPZntAgfp could be used as a monitoring tool for contaminated soils being processed. [less ▲]

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See detailVers une "dématérialisation" des droits fondamentaux? Convergence des droits fondamentaux dans une protection fragmentée, à la lumière du raisonnement du juge constitutionnel belge
Rosoux, Géraldine ULg

in Revue des droits et libertés fondamentaux (2015)

Cet article contient un résumé de thèse (RDLF 2015, thèse n° 10), disponible sur http://www.revuedlf.com/theses/vers-une-dematerialisation-des-droits-fondamentaux-convergence-des-droits-fondamentaux-dans ... [more ▼]

Cet article contient un résumé de thèse (RDLF 2015, thèse n° 10), disponible sur http://www.revuedlf.com/theses/vers-une-dematerialisation-des-droits-fondamentaux-convergence-des-droits-fondamentaux-dans-une-protection-fragmentee-a-la-lumiere-du-raisonnement-du-juge-constitutionnel-belge/ [less ▲]

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See detailImpact of Aphasia on Consciousness Assessment: A Cross-Sectional Study.
Schnakers, C; Bessou, H; Rubi-Fessen, I et al

in Neurorehabilitation & Neural Repair (2015), 29

BACKGROUND: . Previous findings suggest that language disorders may occur in severely brain-injured patients and could interfere with behavioral assessments of consciousness. However, no study ... [more ▼]

BACKGROUND: . Previous findings suggest that language disorders may occur in severely brain-injured patients and could interfere with behavioral assessments of consciousness. However, no study investigated to what extent language impairment could affect patients' behavioral responses. OBJECTIVE: . To estimate the impact of receptive and/or productive language impairments on consciousness assessment. METHODS: . Twenty-four acute and subacute stroke patients with different types of aphasia (global, n = 11; Broca, n = 4; Wernicke, n = 3; anomic, n = 4; mixed, n = 2) were recruited in neurology and neurosurgery units as well as in rehabilitation centers. The Coma Recovery Scale-Revised (CRS-R) was administered. RESULTS: . We observed that 25% (6 out of 24) of stroke patients with a diagnosis of aphasia and 54% (6 out of 11) of patients with a diagnosis of global aphasia did not reach the maximal CRS-R total score of 23. An underestimation of the consciousness level was observed in 3 patients with global aphasia who could have been misdiagnosed as being in a minimally conscious state, even in the absence of any documented period of coma. More precisely, lower subscores were observed on the communication, motor, oromotor, and arousal subscales. CONCLUSION: . Consciousness assessment may be complicated by the co-occurrence of severe language deficits. This stresses the importance of developing new tools or identifying items in existing scales, which may allow the detection of language impairment in severely brain-injured patients. [less ▲]

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See detailL'impôt des personnes morales: un impôt méconnu à (re)découvrir - Actualité, champ d’application et enjeux
Garroy, Sabine ULg

in Bulletin juridique & social (2015), (540), 7-10

La loi-programme du 19 décembre 2014 a littéralement bouleversé le monde des intercommunales : automatiquement assujetties à l’impôt des personnes morales (ci-après : IPM) jusque-là (et quasiment ... [more ▼]

La loi-programme du 19 décembre 2014 a littéralement bouleversé le monde des intercommunales : automatiquement assujetties à l’impôt des personnes morales (ci-après : IPM) jusque-là (et quasiment défiscalisées), la volonté du gouvernement est d’aligner le traitement fiscal des intercommunales sur celui des entreprises privées « normales ». Les personnes morales de droit privé, au premier rang desquelles nous trouvons les associations sans but lucratif (ci-après : ASBL), doivent établir qu’elles ne se livrent pas à une exploitation ou à des opérations de caractère lucratif pour qu’elles soient soumises à l’IPM 1 ; les intercommunales se voient désormais soumises aux mêmes conditions. Ainsi, toutes les intercommunales ne vont pas en principe automatiquement basculer vers l’ISOC. Par contre, toutes les intercommunales, qu’elles demeurent sous le régime de l’IPM ou non, vont connaître des modifications de leur situation fiscale ; nous y reviendrons. Dans les lignes qui suivent, nous exposerons tout d’abord les critères d’assujettissement à l’IPM et à l’ISOC : ces critères constituent bien souvent pour les praticiens un véritable casse-tête chinois (section 1). La question de l’assujettissement est fondamentale vu les di érences qui existent entre ces deux régimes d’imposition ; être assujetti à l’IPM ou à l’ISOC représente donc un enjeu. Au sein même du seul régime d’imposition de l’IPM, nous verrons que des distinctions existent entre différentes catégories d’assujettis et que, là aussi, il est question d’en-jeu fiscal (section 2). Le nouveau régime d’imposition des intercommunales sera notre « fil rouge » ; il permettra de mieux mettre en évidence les implications pratiques des éléments évoqués. [less ▲]

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