References of "Article"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 401 to 500 of 52875     1 2 3 4 5 6 7 8 9 10     Comment j'explore... une dysmorphose dento-maxillo-faciale.Urbain, Valérie; GILON, Yves ; BRUWIER, Annick et alin Revue Médicale de Liège (2016), 71(9), 394-399Dento-maxillofacial dysmorphoses represent a considerable area of maxillofacial surgery. Their incidence has constantly been on the rise since the beginning of the century. This can be explained by ... [more ▼]Dento-maxillofacial dysmorphoses represent a considerable area of maxillofacial surgery. Their incidence has constantly been on the rise since the beginning of the century. This can be explained by variations in the food and society habits.We will first discuss the various causes (congenital and environnemental) and the pathophysiology of these disorders. Then, we will separate them according to the skeletal and Angle’s classifications. We will examine the predictive criteria of these dysmorphoses from the youngest age and consider their clinical and cephalometrical diagnosis We will envisage their functional and aesthetic consequences and expose the preventive options. Finally, we will describe the orthodontic and surgical treatment available today and conclude that surgery remains the gold standard by restoring the conventional axis. [less ▲]Detailed reference viewed: 24 (3 ULg) L’administration Obama, a t-elle (vraiment) navigué à vue sur la scène mondiale ?Santander, Sébastian in Recherches internationales (2016), 106Dès son arrivée au pouvoir, Obama a pris le soin de tenir un discours de rupture avec son prédécesseur dont l’action interventionniste et belliqueuse avait terni l’image des ÉU dans le monde. Il a sous ... [more ▼]Dès son arrivée au pouvoir, Obama a pris le soin de tenir un discours de rupture avec son prédécesseur dont l’action interventionniste et belliqueuse avait terni l’image des ÉU dans le monde. Il a sous-entendu qu’il ne se laisserait pas enfermer dans des cadres idéologiques et qu’il privilégierait une approche « pragmatique » et « souple », et fait savoir qu’il n’engagerait plus les ÉU dans des opérations militaires de grande envergure. Ce discours d’une approche au cas par cas combiné à la politique du retrait militaire d’Irak et d’Afghanistan, et au fait que Obama a parfois été amené à adopter une attitude réactive pour répondre aux soubresauts de l’actualité internationale ont alimenté la perception dominante selon laquelle cette administration se désintéressait et se désengageait du monde, et déployait une politique étrangère marquée par l’indécision, l’improvisation et l’absence de vision à long terme. On ne peut omettre que cette administration a parfois du adapter et ajuster sa politique en fonction des événements internationaux. Faut-il pour autant conclure que sous Obama la première puissance mondiale a navigué à vue sur la scène internationale ? [less ▲]Detailed reference viewed: 118 (68 ULg) Relation entre hygiène bucco-dentaire et tendinopathies chez les sportifsKipgen, Laurence; Kaux, Jean-François ; Rompen, Eric et alin Science & Sports (2016), 31(4), 227-229Detailed reference viewed: 39 (5 ULg) The influence of England on the first English gardens in the Southern Low Countries and the Principality of LiegeDe Harlez De Deulin, Nathalie in Garden History (2016), 44(Automn), 87-100The English Garden appearead in the Low Countries quite late in the 18th century since the geometric model – mainly influenced by the French style diffused by the treatise of Dezallier d’Argenville – is ... [more ▼]The English Garden appearead in the Low Countries quite late in the 18th century since the geometric model – mainly influenced by the French style diffused by the treatise of Dezallier d’Argenville – is still in fashion in the years 1760. Amongst the famous realizations of the time figure the Garden of Leeuwergem Castle (1762), the upper Garden of Freÿr Castle (c. 1775) or the Royal Park of Brussels (1786). The two following decades (1760-1780) correspond to the major development of the new irregular style in the Low Countries merely influenced by Picturesque Garden but also by Naturalistic style Garden discovered by members of the aristocracy travelling in Great Britain as well as some gardeners sent to England to be trained and to learn how to grow new exotic plants. This paper deals with the major designers and the most famous sleeping partners engaged in the program of creation of the first English gardens in the country, notably Prince Charles-Joseph de Ligne (Beloeil and Baudour), Duke Emmanuel de Croÿ (Hermitage), Count of Seneffe Joseph Depestre (Seneffe), Duke Emmanuel d’Hane Steenhuyse (Leeuwergem) and, first of all, Duke Albert de Saxe-Teschen and the Archduchess Marie Christine who asked Lancelot Brown a plan for the site near Brussels called the Fine Mountain (Schoonenberg). Brown has sent his project from Britain in July 1782. We have also taken interest in the many unknown owners who gathered important plants collection that are only described in travel diaries or mentioned in archives (inventories and other lists of purchase or supply) that have no longer survived. This article present some facets of the global research accomplished in the thesis (2015) focusing on the direct influence of the English design on the first irregular gardens in the Southern Low Countries. [less ▲]Detailed reference viewed: 7 (1 ULg) Detailed characterization of the Late Pleistocene loess sequence stratigraphy of Remicourt (Hesbaye region, Belgium) with cone penetration testsDelvoie, Simon ; Boulvain, Frédéric ; Charlier, Robert et alin Geologica Belgica (2016), 19(3-4), 281-289Cone penetration tests (CPT) and drilling results are used to characterize the Middle Belgium loess sequence. A two scale study has been realized in the Hesbaye region (Belgium). The study on a regional ... [more ▼]Cone penetration tests (CPT) and drilling results are used to characterize the Middle Belgium loess sequence. A two scale study has been realized in the Hesbaye region (Belgium). The study on a regional scale was performed along a 18 km long section of the high-speed railway Liège-Brussels. About 230 tests were compiled. Results show the loess thickness is very variable and can locally reach 20 m. Tertiary deposits become continuous and they rapidly thicken from Waremme to the West. The lower surface of the Tertiary deposits is characterized by a 0.3% apparent dipping to the NW. The dipping likely results from the Ardenne Massif uplift. The local scale study focuses on the site of Remicourt located along the high-speed railway. 24 CPT tests have been carried out very close to a series of archaeological trenches. The analysis shows penetrometers are able to define some stratigraphic markers within the loess layer. The most identifiable marker is stratigraphically located around the transition between the Humiferous Complex of Remicourt and the Rocourt Pedocomplex. The lens-shape of the loess ridge is also confirmed by the penetrometers’ interpretation. Furthermore, the 3D morphology of each stratigraphic marker can be estimated. These results offer interesting perspectives for the investigation of the loess sequence related to archaeological applications. [less ▲]Detailed reference viewed: 10 (4 ULg) Unusual Species of Dermatophytes: Rarely Identified or New?HAYETTE, Marie-Pierre ; SACHELI, Rosalie in Mycopathologia (2016)Dermatophytes are causing superficial mycosis in animals and humans. Depending on the geophilic, zoophilic or anthropophilic origin of the fungus but also on the immunological status of the patient ... [more ▼]Dermatophytes are causing superficial mycosis in animals and humans. Depending on the geophilic, zoophilic or anthropophilic origin of the fungus but also on the immunological status of the patient, symptomatology can widely differ. Nevertheless, each species is currently associated with typical clinical manifestations, even if atypical localizations and/or clinical pictures are sometimes also reported. Diagnostic tools applied to species identification have been changing since the last two decades with the more frequent use of molecular methods currently considered nowadays as reference methods for species identification. It becomes obvious that the algorithm used for the distinction of closely related species needs to combine phenotypic and genomic methods. All these different points are discussed, and the most recent novel species causing or involved in human dermatophytosis are reported. [less ▲]Detailed reference viewed: 10 (2 ULg) Cooperative spontaneous emission from indistinguishable atoms in arbitrary motional quantum statesDamanet, François ; Braun, Daniel; Martin, John in Physical Review A (2016), 94We investigate superradiance and subradiance of indistinguishable atoms with quantized motional states, starting with an initial total state that factorizes over the internal and external degrees of ... [more ▼]We investigate superradiance and subradiance of indistinguishable atoms with quantized motional states, starting with an initial total state that factorizes over the internal and external degrees of freedom of the atoms. Due to the permutational symmetry of the motional state, the cooperative spontaneous emission, governed by a recently derived master equation [F. Damanet et al., Phys. Rev. A 93, 022124 (2016)], depends only on two decay rates γ and γ0 and a single parameter dd describing the dipole-dipole shifts. We solve the dynamics exactly for N = 2 atoms, numerically for up to 30 atoms, and obtain the large-N limit by a mean-field approach. We find that there is a critical difference γ0 − γ that depends on N beyond which superradiance is lost. We show that exact nontrivial dark states (i.e., states other than the ground state with vanishing spontaneous emission) only exist for γ = γ0 and that those states (dark when γ = γ0) are subradiant when γ < γ0. [less ▲]Detailed reference viewed: 9 (4 ULg) Work–Home Interface and Well-Being: A Cross-Lagged AnalysisBabic, Audrey ; Stinglhamber, Florence; Bertrand, Françoise et alin Journal of Personnel Psychology (2016)Detailed reference viewed: 16 (3 ULg) Les intérieurs bruxellois et les arts décoratifs dans la seconde moitié du XIXe siècle : entre les modifications du goût et les enjeux didactiques, idéologiques et industrielsPrina, Daniela in Bruxelles Patrimoines (2016), 19-20Detailed reference viewed: 18 (4 ULg) Diurnal variations of hormonal secretion, alertness and cognition in extreme chronotypes under different lighting conditions.Maierova, L.; Borisuit, A.; Scartezzini, L et alin Scientific Reports (2016)Detailed reference viewed: 23 (2 ULg) Du stilus à la plume ... du chapeau. Quelques réflexions sur la notion de styleHoubart, Claudine in Bruxelles Patrimoines (2016), (18), Detailed reference viewed: 19 (4 ULg) Macro-economic factors influencing the architectural business model shift in the pharmaceutical industryDierks, Raphaela Marie Louisa ; Bruyère, Olivier ; Reginster, Jean-Yves et alin Expert Review of Pharmacoeconomics & Outcomes Research (2016), First onlineIntroduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its ... [more ▼]Introduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its underlying business model. Despite significant articles in the press, there is little medical and economic evidence on the rationale driving the transformation from the traditional Research & Development (R&D) model to new alternative business models, such as Mergers & Acquisitions (M&A). The purpose of this review is to understand the macro-economic factors responsible for the revolution of the pharmaceutical business model, by understanding the needs, desires, new behavioral patterns, but also challenges within the industry. Considering these changes will be the key to possessing a competitive advantage over the market players. Areas covered: Existing literature on new macro-economic factors changing the pharmaceutical landscape has been reviewed to present a clear image of the current market environment. Expert commentary: Literature and media sources show that pharmaceutical companies are facing an architectural alteration in their business model, with more M&A deals and collaborations headlining the papers. Although Q1 2016 did show a major slowdown in M&A deals by volume since 2013 (with deal cancellations of Pfizer and Allergan, or the downfall of Valeant) pharmaceutical analysts remain confident that this shortfall was a consequence of the equity market volatility. It seems likely that the shift to an M&A model will become apparent during the remainder of 2016, with deal announcements such as Abbott Laboratories, AbbVie and Sanofi worth USD 45billion [1] showing the appetite of big pharma companies to shift from the fully vertical integrated business model to more horizontal business models. [less ▲]Detailed reference viewed: 37 (11 ULg) La Paméla de Voltaire des Lumières au XXIe siècle - changements de statut et réception générique du texteDaubercies, Laurence in Loxias : Littératures Française et Comparées (2016)Detailed reference viewed: 17 (0 ULg) Determination of iohexol and iothalamate in serum and urine by capillary electrophoresis.Van Houcke, Sofie K.; Seaux, Liesbeth; Cavalier, Etienne et alin Electrophoresis (2016)Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or ... [more ▼]Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or radioactive compounds. However, HPLC is a time-consuming and labour-intensive method. The aim of this study was to develop an assay for iohexol and iothalamate using capillary electrophoresis (CE). Iohexol and iothalamate were directly analysed by CE in serum and urine, using photometric detection (246 nm). Serum peak height was proportional to iohexol and iothalamate concentrations. Detection limits for iohexol and iothalamate were 10 mg/L and 5 mg/L. Limits of quantification were 13.0 mg/L and 15.0 mg/L. Within-run CVs were 4.9% and 6.5%; between-run CVs 3.1-9.9% and 3.8-13.7%. A good correlation was observed between CE and HPLC: y = 1.1703 x + 5.017 (iohexol) and y = 0.7807 x + 11.01 (iothalamate) [y = concentration obtained by CE (mg/L), x = concentration obtained by HPLC (mg/L)]. In addition, CE allowed to determine urinary iohexol concentration. Although the detection limit for CE was higher than for HPLC, CE can still be used for eGFR determination. Advantages of this high throughput method are the absence of sample pretreatment and a minimal sample volume requirement. This article is protected by copyright. All rights reserved. [less ▲]Detailed reference viewed: 14 (0 ULg) Les usages des manuels dans les préparations des enseignants stagiairesScheepers, Caroline in Français Aujourd'Hui (Le) (2016), 194La présente contribution se propose d’analyser la façon dont les manuels sont convoqués par les stagiaires dans leurs préparations de cours de français. Dès lors, la focalisation se place non sur les ... [more ▼]La présente contribution se propose d’analyser la façon dont les manuels sont convoqués par les stagiaires dans leurs préparations de cours de français. Dès lors, la focalisation se place non sur les manuels en tant quel tels, mais sur leur réception et leur réinvestissement dans les pratiques des étudiants. Ont été analysées une centaine de fiches de préparation élaborées par de futurs enseignants belges, qu’ils se destinent à enseigner au primaire, au secondaire inférieur (collège) ou supérieur (lycée). Les usages du manuel révèlent et construisent des différences notables en terme de compétences enseignées, de gestes pédagogiques mobilisés, de rapport au savoir, de culture professionnelle, de formation… Étudier la réception et l’utilisation du manuel revient à problématiser des pratiques et des représentations fondamentales qui touchent à ce que veulent dire enseigner, (faire) apprendre ou construire une leçon. Cette recherche éclaire une facette du processus de planification des apprentissages. [less ▲]Detailed reference viewed: 18 (0 ULg) La responsabilité du supérieur hiérarchique devant la Cour pénale internationale : une première synthèse à la lumière du jugement prononcé dans l’affaire BembaWery, Marine ; Deprez, Christophe in Revue de la Faculté de Droit de l'Université de Liège (2016), 2Le 21 mars 2016, au terme d’une procédure longue de huit années, la Cour pénale internationale (CPI) prononça un verdict de culpabilité à l’encontre de Jean-Pierre Bemba. L’une des innovations majeures ... [more ▼]Le 21 mars 2016, au terme d’une procédure longue de huit années, la Cour pénale internationale (CPI) prononça un verdict de culpabilité à l’encontre de Jean-Pierre Bemba. L’une des innovations majeures liées à cette affaire concerne le vecteur d’imputabilité mobilisé par les juges. Pour la première fois dans l’histoire de la CPI, une chambre de première instance s’est dégagée des modes traditionnels de responsabilité prévus à l’article 25 du Statut de Rome pour sceller le sort d’un accusé sur la base de l’article 28 du même instrument, en application duquel la responsabilité pénale d’un supérieur hiérarchique peut être mise en cause en lien avec les actes commis par ses subordonnés. Par cette contribution, nous proposons d’examiner le verdict du 21 mars 2016, mais aussi les quelques pistes jurisprudentielles préexistantes, afin d’ébaucher une première synthèse du mécanisme de responsabilité du supérieur hiérarchique devant la CPI. [less ▲]Detailed reference viewed: 48 (8 ULg) Circadian dynamics in measures of cortical excitation and inhibition balanceChellappa, Sarah; Gaggioni, Giulia ; LY, Julien et alin Scientific Reports (2016), 6:33661Detailed reference viewed: 20 (8 ULg) Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patientsJurczyszyn, A.; Olszewska-Szopa, M.; Hungria, V. et alin Leukemia & Lymphoma (2016), 57(9 2071-6), 2071-6Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical ... [more ▼]Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS. [less ▲]Detailed reference viewed: 23 (3 ULg) Invasive and Non-invasive Electrical Pericranial Nerve Stimulation for the Treatment of Chronic Primary HeadachesD'Ostilio, Kevin ; MAGIS, Delphine in Current Pain and Headache Reports (2016), 20Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can ... [more ▼]Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well known non-destructive method of pain modulation which has been recently applied to headache management. In this review, we summarise recent advances in invasive and non-invasive neurostimulation techniques targeting pericranial structures for the treatment of chronic primary headaches, chiefly migraine and cluster headache: occipital nerve, supraorbital nerve, vagus nerve, and sphenopalatineganglion stimulations. Invasive neurostimulation therapies have offered a new hope to drug-refractory headache sufferers but are not riskless and should be proposed only to chronic patients who failed to respond to most existing preventives. Non-invasive neurostimulation devices are user-friendly, safe and well tolerated and are thus taking an increasing place in the multidisciplinary therapeutical armamentarium of primary headaches. [less ▲]Detailed reference viewed: 18 (2 ULg) A combined transmission spectrum of the Earth-sized exoplanets TRAPPIST-1 b and cde Wit, Julien; Wakeford, Hannah R.; Gillon, Michaël et alin Nature (2016), 537Three Earth-sized exoplanets were recently discovered close to the habitable zone of the nearby ultracool dwarf star TRAPPIST-1 (ref. 3). The nature of these planets has yet to be determined, as their ... [more ▼]Three Earth-sized exoplanets were recently discovered close to the habitable zone of the nearby ultracool dwarf star TRAPPIST-1 (ref. 3). The nature of these planets has yet to be determined, as their masses remain unmeasured and no observational constraint is available for the planetary population surrounding ultracool dwarfs, of which the TRAPPIST-1 planets are the first transiting example. Theoretical predictions span the entire atmospheric range, from depleted to extended hydrogen-dominated atmospheres. Here we report observations of the combined transmission spectrum of the two inner planets during their simultaneous transits on 4 May 2016. The lack of features in the combined spectrum rules out cloud-free hydrogen-dominated atmospheres for each planet at ≥10σ levels; TRAPPIST-1 b and c are therefore unlikely to have an extended gas envelope as they occupy a region of parameter space in which high-altitude cloud/haze formation is not expected to be significant for hydrogen-dominated atmospheres. Many denser atmospheres remain consistent with the featureless transmission spectrum—from a cloud-free water-vapour atmosphere to a Venus-like one. [less ▲]Detailed reference viewed: 31 (8 ULg) L'EBM peut-elle encore enthousiasmer ?Henrard, Gilles in Minerva: Tijdschrift Voor Evidence Based Medicine (2016)Detailed reference viewed: 9 (1 ULg) The cardiovascular impact of intense eccentric isokinetic exercise versus aerobic treadmill runningLE GOFF, Caroline ; Kaux, Jean-François ; LAURENT, Terry et alin Isokinetics & Exercise Science (2016), 24(3), 201-208BACKGROUND: Regular physical activity is an important health factor, but intense physical stress can increase the risk of heart disease. OBJECTIVE: Our aim was to determine the potential cardiac ... [more ▼]BACKGROUND: Regular physical activity is an important health factor, but intense physical stress can increase the risk of heart disease. OBJECTIVE: Our aim was to determine the potential cardiac repercussions of, and the oxidative stress resulting from a maximal eccentric isokinetic exercise and a 1-hour treadmill run at 75% ˙V O2 max (maximal exercise done 6 weeks before). METHODS: Twelve young sedentary healthy subjects randomly performed two tests separated by 6 weeks: 1) 3 sets of 30 maximal eccentric isokinetic contractions of the quadriceps; 2) a 1-hour running on treadmill at 75% ˙V O2 max. We drew blood samples just before each exercise (T1), and just after (T2), 3 hours after (T3), and 24 hours after (T4) the end of each exercise to measure cardiac and oxidative stress biomarkers. RESULTS: In the running group, we observed significant differences for myoglobin (T3: 145 ± 80 μg/L), creatinine kinase (T4: 593 ± 350 mg/L), oxidized glutathione (T2: 22 ± 15.6 μmol/L), and highly sensitive cardiac troponin T, (T3: 0.051 ± 0.038 ng/mL). In the isokinetic group, we observed significant differences for myoglobin (T3:1419 ± 2533 mg/L), creatine kinase (3303 ± 7159 mg/L), and oxidized glutathione (T4:24 ± 14 μmol/L). Between isokinetic exercise and running, we observed significant differences for uric acid (p < 0.05, running > eccentric), myoglobin (p < 0.05, ditto), NT-proBNP (p < 0.05, ditto), hsTnT (p < 0.01, ditto), and oxidized glutathione (p < 0.05). CONCLUSIONS: As cardiac biomarkers appear practically unmodified after the isokinetic exercise, despite the considerable oxidative stress, we suggest that the application of intense maximal eccentric isokinetic exercise, when indicated, should be safe for most patients including those whose cardiac status is unknown. On the other hand, the increase in cardiac biomarkers observed after running, could reflect leakage of these biomarkers from the cytosolic pool of cardiac cells, linked to membrane damage, rather than the result of a major injury and hence running is supposed to be a safe practice. However, since sudden death during running has been previously described, assesment of the cardiac biomarkers and a follow-up by a sport doctor is important especially if there is a cardiac family history. [less ▲]Detailed reference viewed: 26 (7 ULg) "Je te porte dans moi comme un oiseau blessé" (Louis Aragon)Melice, Anne in Centre Franco Basaglia, Mouvement pour une psychiatrie démocratique dans le milieu de vie (2016)Dans le sillage du texte précédent « Oiseaux blessés. Avec les stagiaires d’Article 23 », ce texte-ci rend compte des spécificités de l’hospitalité que j’ai observées. Ces spécificités s’éclairent à mes ... [more ▼]Dans le sillage du texte précédent « Oiseaux blessés. Avec les stagiaires d’Article 23 », ce texte-ci rend compte des spécificités de l’hospitalité que j’ai observées. Ces spécificités s’éclairent à mes yeux des problématiques du don et du contre-don, du « care », des relations à plaisanterie. Enfin, le respect des singularités et des limites individuelles, ainsi que la mise en suspens des rapports concurrentiels constitutifs du monde de travail, dessinent un espace alternatif à l’égard de ce dernier. [less ▲]Detailed reference viewed: 23 (1 ULg) Les Nouveaux Liégeois. Migrations et Transformations UrbainesLafleur, Jean-Michel ; Stangherlin, Gregorin Dérivations (2016), (3), 194-203Dans cet article, nous proposons de discuter la migration contemporaine sur le territoire de la Ville de Liège. Cette discussion repose pour l’essentiel sur une analyse des données statistiques ... [more ▼]Dans cet article, nous proposons de discuter la migration contemporaine sur le territoire de la Ville de Liège. Cette discussion repose pour l’essentiel sur une analyse des données statistiques disponibles et une revue de la littérature scientifique produite sur les migrations à Liège ces dernières années. Nous commençons donc par une description des grandes évolutions démographiques sur le territoire de la ville depuis 1991 pour insister ensuite sur les effets de la migration dans cinq quartiers de la ville. Cette première partie souligne le rôle essentiel que joue la migration dans la croissance démographique observée ces dix dernières années à Liège. Ensuite, nous examinons la présence étrangère sur le territoire de la ville selon les 5 dimensions fréquemment citées dans les débats sur l’intégration des populations étrangères : emploi, logement, éducation, socio-culturelle et politique. [less ▲]Detailed reference viewed: 345 (17 ULg) Fire Performance of Columns made of Normal and High Strength Concrete: A Comparative AnalysisGernay, Thomas in Key Engineering Materials (2016), 711The use of high strength concrete (HSC) in multi-story buildings has become increasingly popular. Selection of HSC over normal strength concrete (NSC) allows for reducing the dimensions of the columns ... [more ▼]The use of high strength concrete (HSC) in multi-story buildings has become increasingly popular. Selection of HSC over normal strength concrete (NSC) allows for reducing the dimensions of the columns sections. However, this reduction has consequences on the structural performance in case of fire, as smaller cross sections lead to faster temperature increase in the section core. Besides, HSC experiences higher rates of strength loss with temperature and a higher susceptibility to spalling than NSC. The fire performance of a column can thus be affected by selecting HSC over NSC. This research performs a comparison of the fire performance of HSC and NSC columns, based on numerical simulations by finite element method. The thermal and structural analyses of the columns are conducted with the software SAFIR®. The variation of concrete strength with temperature for the different concrete classes is adopted from Eurocode. Different configurations are compared, including columns with the same load bearing capacity and columns with the same cross section. The relative loss of load bearing capacity during the fire is found to be more pronounced for HSC columns than for NSC columns. The impact on fire resistance rating is discussed. These results suggest that consideration of fire loading limits the opportunities for use of HSC, especially when the objective is to reduce the dimensions of the columns sections. [less ▲]Detailed reference viewed: 25 (5 ULg) L'âge de début de l'obligation scolaireBehrendt, Christian in Revue Belge de Droit Constitutionnel (2016), 2016Detailed reference viewed: 22 (3 ULg) Oxytocin in survivors of childhood-onset craniopharyngiomaDaubenbüchel, Anna; Hoffmann, Anika; Eveslage, Maria et alin Endocrine (2016)Quality of survival of childhood-onset cranio- pharyngioma patients is frequently impaired by hypotha- lamic involvement or surgical lesions sequelae such as obesity and neuropsychological deficits ... [more ▼]Quality of survival of childhood-onset cranio- pharyngioma patients is frequently impaired by hypotha- lamic involvement or surgical lesions sequelae such as obesity and neuropsychological deficits. Oxytocin, a pep- tide hormone produced in the hypothalamus and secreted by posterior pituitary gland, plays a major role in regula- tion of behavior and body composition. In a cross- sectional study, oxytocin saliva concentrations were ana- lyzed in 34 long-term craniopharyngioma survivors with and without hypothalamic involvement or treatment- related damage, recruited in the German Childhood Cra- niopharyngioma Registry, and in 73 healthy controls, attending the Craniopharyngioma Support Group Meeting 2014. Oxytocin was measured in saliva of craniophar- yngioma patients and controls before and after standar- dized breakfast and associations with gender, body mass index, hypothalamic involvement, diabetes insipidus, and irradiation were analyzed. Patients with preoperative hypothalamic involvement showed similar oxytocin levels compared to patients without hypothalamic involvement and controls. However, patients with surgical hypotha- lamic lesions grade 1 (anterior hypothalamic area) pre- sented with lower levels (p = 0.017) of oxytocin under fasting condition compared to patients with surgical lesion of posterior hypothalamic areas (grade 2) and patients without hypothalamic lesions (grade 0). Craniophar- yngioma patients’ changes in oxytocin levels before and after breakfast correlated (p = 0.02) with their body mass index. Craniopharyngioma patients continue to secrete oxytocin, especially when anterior hypothalamic areas are not involved or damaged, but oxytocin shows less varia- tion due to nutrition. Oxytocin supplementation should be explored as a therapeutic option in craniopharyngioma patients with hypothalamic obesity and/or behavioral pathologies due to lesions of specific anterior hypotha- lamic areas. Clinical trial number: KRANIOPHAR- YNGEOM 2000/2007(NCT00258453; NCT01272622). [less ▲]Detailed reference viewed: 24 (2 ULg) Using a structural root system model for an in-depth assessment of root image analysis pipelineLobet, Guillaume ; Koevoets, Iko; Tocquin, Pierre et alin bioRxiv (2016)Root system analysis is a complex task, often performed using fully automated image analysis pipelines. However, these pipelines are usually evaluated with a limited number of ground-truth root images ... [more ▼]Root system analysis is a complex task, often performed using fully automated image analysis pipelines. However, these pipelines are usually evaluated with a limited number of ground-truth root images, most likely of limited size and complexity. We have used a root model, ArchiSimple to create a large and diverse library of ground-truth root system images (10.000). This library was used to evaluate the accuracy and usefulness of several image descriptors classicaly used in root image analysis pipelines. Our analysis highlighted that the accuracy of the different metrics is strongly linked to the type of root system analyzed (e.g. dicot or monocot) as well as their size and complexity. Metrics that have been shown to be accurate for small dicot root systems might fail for large dicots root systems or small monocot root systems. Our study also demonstrated that the usefulness of the different metrics when trying to discriminate genotypes or experimental conditions may vary. Overall, our analysis is a call to caution when automatically analyzing root images. If a thorough calibration is not performed on the dataset of interest, unexpected errors might arise, especially for large and complex root images. To facilitate such calibration, both the image library and the different codes used in the study have been made available to the community. [less ▲]Detailed reference viewed: 18 (2 ULg) The Case : Acute renal failure and refractory hyponatremiadenis, Chloé; JADOT, Virginie ; BOUQUEGNEAU, Antoine et alin Kidney International (2016), 90Detailed reference viewed: 22 (9 ULg) Effect of citrate anticoagulation on CO2 extraction during low flow extracorporeal veno-venous CO2 removal therapyMORIMONT, Philippe ; Habran, Simon ; Hubert, Romain et alin Intensive Care Medicine Experimental (2016), 4Detailed reference viewed: 20 (2 ULg) Congenital venous aneurysm of the right external jugular vein in a great daneLefebvre, Michaël ; Merveille, Anne-Christine ; Rizza, Maïlis et alin Veterinary Record Case Reports (2016)Detailed reference viewed: 14 (0 ULg) Visual and auditory cortical evoked potentials in interictal episodic migraine: An audit on 624 patients from three centres.Ambrosini, Anna; Kisialou, A; Coppola, Gianluca et alin Cephalalgia : An International Journal of Headache (2016)Detailed reference viewed: 11 (1 ULg) Le décret décumul et le Parlement wallonGrandjean, Geoffrey ; Janssens, Frédéricin Administration Publique: Revue du Droit Public et des Sciences Administratives (2016), 2Detailed reference viewed: 16 (6 ULg) Will climate change affect insect pheromonal communication?Boullis, Antoine ; Detrain, Claire; Francis, Frédéric et alin Current Opinion in Insect Science (2016)Understanding how climate change will affect species interactions is a challenge for all branches of ecology. We have only limited understanding of how increasing temperature and atmospheric CO2 and O3 ... [more ▼]Understanding how climate change will affect species interactions is a challenge for all branches of ecology. We have only limited understanding of how increasing temperature and atmospheric CO2 and O3 levels will affect pheromone-mediated communication among insects. Based on the existing literature, we suggest that the entire process of pheromonal communication, from production to behavioural response, is likely to be impacted by increases in temperature and modifications to atmospheric CO2 and O3 levels. We argue that insect species relying on long-range chemical signals will be most impacted, because these signals will likely suffer from longer exposure to oxidative gases during dispersal. We provide future directions for research programmes investigating the consequences of climate change on insect pheromonal communication. [less ▲]Detailed reference viewed: 37 (7 ULg) Psychological transition and adjustment processes related to retirement: Influence on cognitive functioningGrotz, Catherine ; Matharan, Fanny; Pérès, Karine et alin Aging & Mental Health (2016)Objective: To investigate the relationship between psychological transition and adjustment to retirement and cognitive performances in older adults. Methods: The study’s sample was taken from the Approche ... [more ▼]Objective: To investigate the relationship between psychological transition and adjustment to retirement and cognitive performances in older adults. Methods: The study’s sample was taken from the Approche Multidisciplinaire Int egr ee cohort, a French prospective study of retirees from agriculture, aged 65 and over, living in rural settings in southwestern France. The cross-sectional analyses were conducted on a sample of 590 elderly people without dementia at baseline and for whom information on perception of the work setting, experience of the retirement transition and adaptation to retirement life (nine variables) as well as neuropsychological measures (global cognitive functioning, episodic memory, verbal fluency, attention and psychomotor speed) were available at first visit. Results: Multivariable linear regression analyses, including nine variables related to retirement and adjusted for potential confounding factors, indicated that three of them positive consideration of former work situation, development of new activities during retirement and good adaptation to free time were associated with better cognitive performances. Conclusions: We found that several factors proved to be determinants of good cognitive functioning at retirement and could serve as a basis for the development of more efficient intervention programs aimed at helping retirees to maintain good cognitive functioning after retirement. [less ▲]Detailed reference viewed: 19 (3 ULg) Systemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD.Stolz, Daiana; Leeming, Diana Julie; Edfort Kristensen, Jacob Hull et alin CHEST (2016)BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic ... [more ▼]BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic obstructive pulmonary disease (COPD). We aimed to assess the association of ECM turnover with severity and outcome of COPD. METHODS: In a prospective, observational, multicenter study including 506 patients with COPD, GOLD grades II-IV, we analyzed serum samples at stable state, exacerbation and 4 weeks after exacerbation, for a panel of 5 novel neo-epitopes including fragments of collagen type-III (C3M) and type-VI (C6M), pro-forms of collagen type-III (Pro-C3) and type-VI (Pro-C6) and neutrophil elastase-generated fragments of elastin (EL-NE) by ELISA. These neo-epitopes were also measured at stable state in a derivation cohort including 100 COPD patients. RESULTS: Serum levels of C3M, C6M, Pro-C3, Pro-C6 and EL-NE were associated with lung function. Patients with the lowest levels of Pro-C3 and Pro-C6 had more severe airflow limitation, hyperinflation, air trapping, and emphysema. Degradation of collagen type-III and -VI was associated with dyspnea. All ECM biomarkers, except Pro-C6, were increased at exacerbation as compared to stable state but, except EL-NE, did not differ between stable state and exacerbation follow-up in the crude and adjusted analyses. In Cox regression adjusted analyses, Pro-C3 was associated with a shorter time to exacerbation (HR 0.72[0.59-0.89] p=0.002) and Pro-C6 with survival (HR 2.09[1.18-3.71], p=0.011). CONCLUSIONS: Serum biomarkers of ECM turnover are significantly associated with disease severity and clinically relevant outcomes in COPD. [less ▲]Detailed reference viewed: 9 (1 ULg) Fertility progression in Germany: an analysis using flexible nonparametric cure survival modelsBremhorst, Vincent; Kreyenfeld, Michaela; Lambert, Philippe in Demographic Research (2016)OBJECTIVE This paper uses data from the German Socio-Economic Panel (GSOEP) to study the transition to second and third births. In particular, we seek to distinguish the factors that determine the timing ... [more ▼]OBJECTIVE This paper uses data from the German Socio-Economic Panel (GSOEP) to study the transition to second and third births. In particular, we seek to distinguish the factors that determine the timing of fertility from the factors that influence ultimate parity progression. METHODS We employ cure survival models, a technique commonly used in epidemiological studies and in the statistical literature but only rarely applied to fertility research. RESULTS We find that education has a different impact on the timing and the ultimate probability of having a second and a third birth. Furthermore, we show that the shape of the fertility schedule for the total population differs from that of ‘susceptible women’ (i.e., those who have a second or a third child). CONCLUSION Standard event history models conflate timing and quantum effects. Our approach overcomes this shortcoming. It estimates separate parameters for the hazard rate of having a next child for the ‘susceptible population’ and the ultimate probability of having another child for the entire population at risk. [less ▲]Detailed reference viewed: 68 (5 ULg) Evaluation of the Effect of Two Volatile Organic Compounds on Barley PathogensKaddes, Amine ; Parisi, Olivier ; Berhal, Chadi et alin Molecules (2016), 21(9), Detailed reference viewed: 32 (10 ULg) Determining new threshold temperatures for cooling and heating degree day index of different climatic zones of IranRoshan, Gh.R.; Ghanghermeh, A.A.; Attia, Shady in Renewable Energy : An International Journal (2016), 101(2017), 156-167Iran is a country with a variety of different climates. Determining the threshold temperatures suitable for providing thermal and climatic comfort is necessary and vital to its population well-being. This ... [more ▼]Iran is a country with a variety of different climates. Determining the threshold temperatures suitable for providing thermal and climatic comfort is necessary and vital to its population well-being. This research presents new threshold temperatures in order to calculate the degree day index required for heating and cooling by taking advantage of the 12 stations that are representative of the diversity of Iran's climate. Using Olgyay diagram, different bioclimatic ranges of 12 weather stations and their frequencies were compiled, processes and analysed. Mean daily data of temperature and relative humidity were used for the period of 1950e2010. Based on the frequencies of temperature readings falling in Olgyay's diagram comfort zone, representive temperature thresholds were selected based on 40 to 60 percentiles or (P20), 25e75% percentile (P50) and the threshold of 10e90% percentile. The findings of this study shows that Mashhad with 29.6% and Anzali with 2.33% of frequencies, have experienced the maximum and minimum days of comfort. After analyzing various percentiles to determine the threshold temperatures, it was observed that there is a little difference among the stations for determining the minimum threshold for the comfort. Differences are more obvious in the maximum thresholds. In total, minimum base temperatures (HDD) belonged to Ardabil stations that were 20.50, 20.90 and 20 deg C for P20, P50 and P80 respectively. The maximum temperature for calculating CDD with values of (P20 ¼ 25 C; P50 ¼ 26.25 C; P80 ¼ 27.50 C) is dedicated to Zabol station. The findings present more reasonable thermal comfort thresholds that can be used by architects, engineers and policy makers to achieve, in turn, more energy efficient homes and high quality indoor and outdoor living environments. [less ▲]Detailed reference viewed: 44 (5 ULg) Ageism in Belgium and Burundi: A comparative analysisMarquet, Manon ; Missotten, Pierre ; Schroyen, Sarah et alin Clinical Interventions in Aging (2016), 11Background: Recent cross-cultural comparisons between Asian and Western cultures have shown that ageism arises more from the lack of availability of social and economic resources for older adults than ... [more ▼]Background: Recent cross-cultural comparisons between Asian and Western cultures have shown that ageism arises more from the lack of availability of social and economic resources for older adults than from the culture itself. We tested this assumption by conducting a survey among people living in a least-developed country compared with a developed country. Methods: Twenty-seven Belgians living in Belgium, 29 Burundians living in Belgium and 32 Burundians living in Burundi were included in this study. Their attitudes toward older adults were assessed using several self-reported measures. Results: Statistical analyses confirmed that older people are more negatively perceived by Burundians living in Burundi than by Burundians and Belgians living in Belgium, whose attitudes did not differ from each other. Conclusion: Consistent with our hypothesis, our results suggest that the level of development of a country and more particularly the lack of government spending on older people (pension and healthcare systems) may contribute to their younger counterparts perceiving them more negatively. [less ▲]Detailed reference viewed: 45 (8 ULg) Graphene-multiferroic interfaces for spintronics applicationsZanolli, Zeila in Scientific Reports (2016)Graphene and magnetoelectric multiferroics are promising materials for spintronic devices with high performance and low energy consumption. A very long spin di usion length and high carrier mobility make ... [more ▼]Graphene and magnetoelectric multiferroics are promising materials for spintronic devices with high performance and low energy consumption. A very long spin di usion length and high carrier mobility make graphene attractive for spintronics. The coupling between ferroelectricity and magnetism, which characterises magnetoelectrics, opens the way towards unique device architectures. In this work, we combine the features of both materials by investigating the interface between graphene and BaMnO3, a magnetoelectric multiferroic. We show that electron charge is transferred across the interface and magnetization is induced in the graphene sheet due to the strong interaction between C and Mn. Depending on the relative orientation of graphene and BaMnO3, a quasi-half-metal or a magnetic semiconductor can be obtained. A remarkably large proximity induced spin splitting of the Dirac cones (~300 meV) is achieved. We also show how doping with acceptors can make the high-mobility region of the electronic bands experimentally accessible. This suggests a series of possible applications in spintronics (e.g. spin filters, spin injectors) for hybrid organic-multiferroic materials and reveals hybrid organic-multiferroics as a new class of materials that may exhibit exotic phenomena such as the quantum anomalous Hall effect and a Rashba spin-orbit induced topological gap. [less ▲]Detailed reference viewed: 18 (2 ULg) SO(10) models with flavour symmetries: Classification and examplesIvanov, Igor ; Lavoura, Luisin Journal of Physics : G Nuclear & Particle Physics (2016), 43(10), 105005Renormalizable SO(10) grand unified theory (GUT) models equipped with flavour symmetries are a popular framework for addressing the flavour puzzle. Usually, the flavour symmetry group has been an ad hoc ... [more ▼]Renormalizable SO(10) grand unified theory (GUT) models equipped with flavour symmetries are a popular framework for addressing the flavour puzzle. Usually, the flavour symmetry group has been an ad hoc choice, and no general arguments limiting this choice were known. In this paper, we establish the full list of flavour symmetry groups which may be enforced, without producing any further accidental symmetry, on the Yukawa-coupling matrices of an SO(10) GUT with arbitrary numbers of scalar multiplets in the ${\bf{10}}$, $\bar{{\bf{126}}}$, and ${\bf{120}}$ representations of SO(10). For each of the possible discrete non-Abelian symmetry groups, we present examples of minimal models which do not run into obvious contradiction with the phenomenological fermion masses and mixings. [less ▲]Detailed reference viewed: 8 (1 ULg) La gestion de la matière organique du sol, un enjeu important pour limiter la lixiviation du nitrate vers les eaux souterrainesVandenberghe, Christophe ; Colinet, Gilles in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 21Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive ... [more ▼]Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive (ND). This vulnerable area has a relatively high diversity of agro-soil environments. Thus, the nitrogen content of agricultural soils can vary locally by a factor 4. Objectives. This study aimed to establish whether the carbon content of a soil is a significant risk factor in nitrate leaching to groundwater. Method. The article is based on measurements of nitrate nitrogen residue (APL) and soil total organic carbon (TOC) at the beginning of the leaching period. The measurements were made in 2012 in 1,500 plots, during inspections organized by the Wallonia Public Service. This was as part of the application of the Program for the Sustainable Management of Nitrogen in Agriculture, the scheme for implementing the ND within the Walloon region. Results. Examination of the results showed both that the APL was positively correlated to the TOC and that plots with “noncompliant” APL results had a significantly higher average TOC than the other plots. Conclusions. Since APL is an environmental indicator of the risk of nitrate leaching, it appears that the TOC may constitute a risk of groundwater contamination by nitrate. It is therefore advisable to improve the inclusion of this parameter in advice regarding nitrogen fertilization and secondly, in the case of summer harvest, to better manage the sowing of catch crops. [less ▲]Detailed reference viewed: 8 (1 ULg) New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivityHenry, Aurélie ; Nokin, Marie-Julie ; Leroi, Natacha et alin Oncotarget (2016)Glioblastoma (GBM) represents the most aggressive and common solid human brain tumor. We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness ... [more ▼]Glioblastoma (GBM) represents the most aggressive and common solid human brain tumor. We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells. Consultation of publicly available TCGA database indicated that high OPN expression correlated with poor survival in GBM patients. In this study, we explored the role of OPN in GBM radioresistance using an OPN-depletion strategy in U87-MG, U87-MG vIII and U251-MG human GBM cell lines. Clonogenic experiments showed that OPN-depleted GBM cells were sensitized to irradiation. In comet assays, these cells displayed higher amounts of unrepaired DNA fragments post-irradiation when compared to control. We next evaluated the phosphorylation of key markers of DNA double-strand break repair pathway. Activating phosphorylation of H2AX, ATM and 53BP1 was signi cantly decreased in OPN-de cient cells. The addition of recombinant OPN prior to irradiation rescued phospho-H2AX foci formation thus establishing a new link between DNA repair and OPN expression in GBM cells. Finally, OPN knockdown improved mice survival and induced a signi cant reduction of heterotopic human GBM xenograft when combined with radiotherapy. This study reveals a new function of OPN in DNA damage repair process post-irradiation thus further con rming its major role in GBM aggressive disease. [less ▲]Detailed reference viewed: 12 (5 ULg) AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanomaConteduca, Giuseppina in Oncotarget (2016)AIRE is involved in susceptibility to melanoma perhaps regulating T cell immunity against melanoma antigens (MA). To address this issue, AIRE and MAGEB2 expressions were measured by real time PCR in ... [more ▼]AIRE is involved in susceptibility to melanoma perhaps regulating T cell immunity against melanoma antigens (MA). To address this issue, AIRE and MAGEB2 expressions were measured by real time PCR in medullary thymic epithelial cells (mTECs) from two strains of C57BL/6 mice bearing either T or C allelic variant of the rs1800522 AIRE SNP. Moreover, the extent of apoptosis induced by mTECs in MAGEB2-specific T cells and the susceptibility to in vivo melanoma B16F10 cell challenge were compared in the two mouse strains. The C allelic variant, protective in humans against melanoma, induced lower AIRE and MAGEB2 expression in C57BL/6 mouse mTECs than the T allele. Moreover, mTECs expressing the C allelic variant induced lower extent of apoptosis in MAGEB2-specific syngeneic T cells than mTECs bearing the T allelic variant (p < 0.05). Vaccination against MAGEB2 induced higher frequency of MAGEB2-specific CTL and exerted higher protective effect against melanoma development in mice bearing the CC AIRE genotype than in those bearing the TT one (p < 0.05). These findings show that allelic variants of one AIRE SNP may differentially shape the MA-specific T cell repertoire potentially influencing susceptibility to melanoma. [less ▲]Detailed reference viewed: 9 (2 ULg) Ability of Tuta absoluta (Lepidoptera: Gelechiidae) to develop on alternative host plant speciesBawin, Thomas ; Dujeu, David; De Backer, Lara et alin Canadian Entomologist (2016), 148(4), 434-442The tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous crops. The characterization of its host ... [more ▼]The tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous crops. The characterization of its host range could help to understand and prevent the dispersion behavior of the insect in the environment. In this study, the ability of T. absoluta to develop on 12 cultivated or non-cultivated plants including Solanaceae, Chenopodiaceae, Convolvulaceae, Fabaceae and Malvaceae species under laboratory conditions was assessed. For each plant species, we monitored the development times of immature stages, survival, sex ratios and adult fecundity rates. All the 6 tested non-solanaceous plants, including Chenopodium, Convolvulus and Malva species, were not able to sustain (i.e. allow growth and development) T. absoluta larvae. Among Solanaceae, Solanum species were the most suitable host plants for the pest, but others could be opportunistically colonized with fewer incidences. T. absoluta appears to be strongly related to solanaceous plants which would predominantly support self-sustaining field populations. Preventing crop infestation by removing potential host plants in the immediate field vicinity and culture rotations with non-solanaceous crops is of primary importance. [less ▲]Detailed reference viewed: 79 (17 ULg) Two-Parameter Kinematic Approach for Shear Strength of Deep Concrete Beams with Internal FRP ReinforcementMihaylov, Boyan in Journal of Composites for Construction (2016), DOI: 10.1061/(ASCE)CC.1943-5614 .0000747Tests of deep concrete beams with internal fiber-reinforced polymer (FRP) reinforcement have shown that such members can exhibit lower shear strength than members with conventional steel reinforcement. To ... [more ▼]Tests of deep concrete beams with internal fiber-reinforced polymer (FRP) reinforcement have shown that such members can exhibit lower shear strength than members with conventional steel reinforcement. To model this effect, the current paper proposes an approach based on a two-parameter kinematic theory (2PKT) for conventional deep beams. The 2PKT is built on a kinematic model with two degrees of freedom that describes the deformation patterns of cracked beams. Using this theory shows that large strains in FRP longitudinal reinforcement result in reduced shear resistance of the critical loading zones (CLZ) of deep beams. The original 2PKT is therefore modified by introducing a reduction factor for the shear carried by the CLZ. The extended 2PKT approach is then applied to a database of 39 tests of FRP-reinforced deep beams from the literature, resulting in an average shear strength experimental-to-predicted ratio of 1.06 and a coefficient of variation of 18.3%. The results show that the 2PKT adequately captures the effects of the stiffness of the reinforcement, section depth, concrete strength, and shear-span-to-depth ratio on the shear strength of FRP-reinforced deep beams. [less ▲]Detailed reference viewed: 11 (3 ULg) Incorporation of iron and organic matter into young Antarctic sea ice during its initial growth stagesJanssens, Julie; Meiners, Klaus M.; Tison, Jean-Louis et alin Elementa: Science of the Anthropocene (2016), 4(1), 000123This study reports concentrations of iron (Fe) and organic matter in young Antarctic pack ice and during its initial growth stages in situ. Although the importance of sea ice as an Fe reservoir for ... [more ▼]This study reports concentrations of iron (Fe) and organic matter in young Antarctic pack ice and during its initial growth stages in situ. Although the importance of sea ice as an Fe reservoir for oceanic waters of the Southern Ocean has been clearly established, the processes leading to the enrichment of Fe in sea ice have yet to be investigated and quantified. We conducted two in situ sea-ice growth experiments during a winter cruise in the Weddell Sea. Our aim was to improve the understanding of the processes responsible for the accumulation of dissolved Fe (DFe) and particulate Fe (PFe) in sea ice, and of particulate organic carbon and nitrogen, dissolved organic carbon, extracellular polymeric substances, inorganic macro-nutrients (silicic acid, nitrate and nitrite, phosphate and ammonium), chlorophyll a and bacteria. Enrichment indices, calculated for natural young ice and ice newly formed in situ, indicate that during Antarctic winter all of the measured forms of particulate matter were enriched in sea ice compared to underlying seawater, and that enrichment started from the initial stages of sea-ice formation. Some dissolved material (DFe and ammonium) was also enriched in the ice but at lower enrichment indices than the particulate phase, suggesting that size is a key factor for the incorporation of impurities in sea ice. Low chlorophyll a concentrations and the fit of the macro-nutrients (with the exception of ammonium) with their theoretical dilution lines indicated low biological activity in the ice. From these and additional results we conclude that physical processes are the dominant mechanisms leading to the enrichment of DFe, PFe, organic matter and bacteria in young sea ice, and that PFe and DFe are decoupled during sea-ice formation. Our study thus provides unique quantitative insight into the initial incorporation of impurities, in particular DFe and PFe, into Antarctic sea ice. [less ▲]Detailed reference viewed: 38 (3 ULg) MME mutation in dominant spinocerebellar ataxia with neuropathy (SCA43)Depondt; Donatello, Simona; Rai, Myriam et alin Neurology genetics (2016)Detailed reference viewed: 13 (1 ULg) Model Sensitivity Studies of the Decrease in Atmospheric Carbon TetrachlorideChipperfield, M. P.; Liang, Q.; Rigby, M. et alin Atmospheric Chemistry & Physics Discussions (2016), 2016Carbon tetrachloride is an ozone-depleting substance, which is controlled by the Montreal Protocol and for which the atmospheric abundance is decreasing. However, the current observed rate of this ... [more ▼]Carbon tetrachloride is an ozone-depleting substance, which is controlled by the Montreal Protocol and for which the atmospheric abundance is decreasing. However, the current observed rate of this decrease is known to be slower than expected based on reported CCl4 emissions and its estimated overall atmospheric lifetime. Here we use a three-dimensional (3-D) chemical transport model to investigate the impact on its predicted decay of uncertainties in the rates at which CCl4 is removed from the atmosphere by photolysis, by ocean uptake and by degradation in soils. The largest sink is atmospheric photolysis (76% of total) but a reported 10% uncertainty in its combined photolysis cross-section and quantum yield has only a modest impact on the modelled rate of CCl4 decay. This is partly due to the limiting effect of the rate of transport of CCl4 from the main tropospheric reservoir to the stratosphere where photolytic loss occurs. The model suggests large interannual variability in the magnitude of this stratospheric photolysis sink caused by variations in transport. The impact of uncertainty in the minor soil sink (9% of total) is also relatively small. In contrast, the model shows that uncertainty in ocean loss (15% of total) has the largest impact on modelled CCl4 decay due to its sizeable contribution to CCl4 loss and large uncertainty range (157 to 313 years). With an assumed CCl4 emission rate of 39 Gg/yr, the reference simulation with best estimate of loss processes still underestimates the observed CCl4 (overestimates the decay) over the past two decades but to a smaller extent than previous studies. Changes to the rate of CCl4 loss processes, in line with known uncertainties, could bring the model into agreement with in situ surface and remote-sensing measurements, as could an increase in emissions to around 45 Gg/yr. Further progress in constraining the CCl4 budget is partly limited by systematic biases between observational datasets. For example, surface observations from the NOAA network are larger than from the AGAGE network but have shown a steeper decreasing trend over the past two decades. These differences imply a difference in emissions which is significant relative to uncertainties in the magnitudes of the CCl4 sinks. [less ▲]Detailed reference viewed: 36 (0 ULg) Émotion, ipséité, liberté. Réflexions à propos des fondements de la théorie sartrienne des émotionsRecchia, Fabio in Bulletin d'Analyse Phénoménologique (2016), 12(5), 1-23Entretenue durant la drôle de guerre, la correspondance épistolaire entre De Beauvoir et Sartre révèle une insatisfaction de ce dernier à l'égard de sa théorie des émotions. Celle-ci manquerait en effet ... [more ▼]Entretenue durant la drôle de guerre, la correspondance épistolaire entre De Beauvoir et Sartre révèle une insatisfaction de ce dernier à l'égard de sa théorie des émotions. Celle-ci manquerait en effet de fondements solides. Répondant à ce constat, nous tenterons de dégager les fondations de cette théorie de manière à expliciter ses enjeux. Nous replacerons, pour ce faire, l'Esquisse d'une théorie des émotions dans la perspective plus générale de la théorie de l'intentionnalité du premier Sartre. De la sorte nous montrerons, d'une part, comment ce texte renouvelle significativement la catégorie de l'action en concevant l'émotion comme une activité ; et nous examinerons, d'autre part, l'interaction existant entre l¿émotion et l'ipséité de la conscience. Cette discussion dévoilera ainsi l'intentionnalité émotive comme une passion active reconduisant au fondement de la conscience qui est sa liberté personnelle. [less ▲]Detailed reference viewed: 35 (9 ULg) Use of slow-release plant infochemicals to control aphids: a first investigation in a Belgian wheat fieldZhou, Haibo; Chen, Longsheng; Liu, Yong et alin Scientific Reports (2016)Using infochemicals to develop a push–pull strategy in pest control is a potential way to promote sustainable crop production. Infochemicals from plant essential oils were mixed with paraffin oil for slow ... [more ▼]Using infochemicals to develop a push–pull strategy in pest control is a potential way to promote sustainable crop production. Infochemicals from plant essential oils were mixed with paraffin oil for slow release in field experiments on wheat to control the population density of cereal aphids and to enhance their natural enemies. (Z)-3-Hexenol (Z3H) attracted Metopolophum dirhodum and Sitobion avenae, the predominant species on wheat in Belgium, and may be a useful infochemical for aphid control by attracting aphids away from field plots. Release of (E)-β-farnesene (EBF) or a garlic extract (GE) led to a significant decrease in the abundance of wheat aphids. The main natural enemies of cereal aphids found were lacewings (47.8%), hoverflies (39.4%), and ladybirds (12.8%). Ladybird abundance varied little before the end of the wheat-growing season. Our results suggest that these chemicals can form the basis of a “push–pull” strategy for aphid biological control, with GE and EBF acting as a pestand beneficial-pulling stimulus and Z3H for aphid pulling. [less ▲]Detailed reference viewed: 27 (5 ULg) Diagnostic Algorithm in the Management of Acute Febrile Abdomen in Patients with Autosomal Dominant Polycystic Kidney DiseaseNEUVILLE, Marie ; Hustinx, Roland ; JACQUES, Jessica et alin PLoS ONE (2016)Detailed reference viewed: 27 (6 ULg) Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7Szpakowska, Martyna; Dupuis, Nadine ; Baragli, Alessandra et alin Biochemical Pharmacology (2016), 114Detailed reference viewed: 26 (8 ULg) A new global interior ocean mapped climatology: the 1° × 1° GLODAP version 2Lauvset, Siv K.; Key, Robert M.; Olsen, Are et alin Earth System Science Data (2016)Detailed reference viewed: 32 (6 ULg) Do Agrometeorological Data Improve Optical Satellite-based Estimations of Herbaceous Yield in Sahelian Semi-Arid Ecosystems?Diouf, Abdoul Aziz ; Hiernaux, Pierre; Brandt, Martin et alin Remote Sensing (2016), 8Quantitative estimates of forage availability at the end of the growing season in rangelands are helpful for pastoral livestock managers and for local, national and regional stakeholders in natural ... [more ▼]Quantitative estimates of forage availability at the end of the growing season in rangelands are helpful for pastoral livestock managers and for local, national and regional stakeholders in natural resource management. For this reason, remote sensing data such as the Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) have been widely used to assess Sahelian plant productivity for about 40 years. This study combines traditional FAPAR-based assessments with agrometeorological variables computed by the geospatial water balance program, GeoWRSI, using rainfall and potential evapotranspiration satellite gridded data to estimate the annual herbaceous yield in the semi-arid areas of Senegal. It showed that a machine-learning model combining FAPAR seasonal metrics with various agrometeorological data provided better estimations of the in situ annual herbaceous yield (R² = 0.69; RMSE = 483kg•DM/ha) than models based exclusively on FAPAR metrics (R² = 0.63; RMSE = 550kg•DM/ha) or agrometeorological variables (R² = 0.55; RMSE = 585kg•DM/ha). All the models provided reasonable outputs and showed a decrease in the mean annual yield with increasing latitude, together with an increase in relative inter-annual variation. In particular, the additional use of agrometeorological information mitigated the saturation effects that characterize the plant indices of areas with high plant productivity. In addition, the date of the onset of the growing season derived from smoothed FAPAR seasonal dynamics showed no significant relationship (0.05 p-level) with the annual herbaceous yield across the whole studied area. The date of the onset of rainfall however, was significantly related to the herbaceous yield and its inclusion in fodder biomass models could constitute a significant improvement in forecasting risks of a mass herbaceous deficit at an early stage of the year. [less ▲]Detailed reference viewed: 16 (6 ULg) Ulcerative pododermatitis and disseminated erosive lesions associated with cowpox virus infection in a domestic catLudwig, Louisa ; Bohn, Jéromine ; Remy, Isabelle et alin Veterinary Record Case Reports (2016)The authors report on a case of feline cowpox virus infection associated with severe ulcerative dermatitis of a paw and disseminated erosive lesions. While the anamnesis of the cat being a known rodent ... [more ▼]The authors report on a case of feline cowpox virus infection associated with severe ulcerative dermatitis of a paw and disseminated erosive lesions. While the anamnesis of the cat being a known rodent-hunter, a typical seasonality of infection and the progression of clinical signs from a primary anterior lesion (forelimb) indicated a possible cowpox virus infection, the differential diagnosis was complicated by the resemblance of clinical signs to those induced by feline herpesvirus-dermatitis or feline calicivirus infection. These differential diagnoses were excluded by means of immunostaining and PCR, respectively. Detection of eosinophilic intracytoplasmic inclusion bodies in cells from biopsy material and positive PCR and sequencing results confirmed the diagnosis of cowpox virus infection. Genetic characterisation of the isolate, based on the highly diverse haemagglutinin gene, showed that the strain (Liege 2015; GenBank accession number: KU726584) clustered with other European isolates, mostly from exotic zoo animals. [less ▲]Detailed reference viewed: 19 (2 ULg) Characterization of stony soils' hydraulic conductivity using laboratory and numerical experimentsBeckers, Eléonore ; Pichault, Mathieu; Pansak, Wanwisa et alin SOIL (2016), 2Determining soil hydraulic properties is of major concern in various fields of study. Although stony soils are widespread across the globe, most studies deal with gravel-free soils, so that the literature ... [more ▼]Determining soil hydraulic properties is of major concern in various fields of study. Although stony soils are widespread across the globe, most studies deal with gravel-free soils, so that the literature describing the impact of stones on the hydraulic conductivity of a soil is still rather scarce. Most frequently, models characterizing the saturated hydraulic conductivity of stony soils assume that the only effect of rock fragments is to reduce the volume available for water flow, and therefore they predict a decrease in hydraulic conductivity with an increasing stoniness. The objective of this study is to assess the effect of rock fragments on the saturated and unsaturated hydraulic conductivity. This was done by means of laboratory experiments and numerical simulations involving different amounts and types of coarse fragments. We compared our results with values predicted by the aforementioned predictive models. Our study suggests that it might be ill-founded to consider that stones only reduce the volume available for water flow. We pointed out several factors of the saturated hydraulic conductivity of stony soils that are not considered by these models. On the one hand, the shape and the size of inclusions may substantially affect the hydraulic conductivity. On the other hand, laboratory experiments show that an increasing stone content can counteract and even overcome the effect of a reduced volume in some cases: we observed an increase in saturated hydraulic conductivity with volume of inclusions. These differences are mainly important near to saturation. However, comparison of results from predictive models and our experiments in unsaturated conditions shows that models and data agree on a decrease in hydraulic conductivity with stone content, even though the experimental conditions did not allow testing for stone contents higher than 20 %. [less ▲]Detailed reference viewed: 24 (3 ULg) Annual Greenland accumulation rates (2009–2012) from airborne snow radarKoenig, L.; Ivanoff, A.; Alexander, P. et alin Cryosphere (The) (2016), 10Contemporary climate warming over the Arctic is accelerating mass loss from the Greenland Ice Sheet through increasing surface melt, emphasizing the need to closely monitor its surface mass balance in ... [more ▼]Contemporary climate warming over the Arctic is accelerating mass loss from the Greenland Ice Sheet through increasing surface melt, emphasizing the need to closely monitor its surface mass balance in order to improve sea-level rise predictions. Snow accumulation is the largest component of the ice sheet's surface mass balance, but in situ observations thereof are inherently sparse and models are difficult to evaluate at large scales. Here, we quantify recent Greenland accumulation rates using ultra-wideband (2–6.5 GHz) airborne snow radar data collected as part of NASA's Operation IceBridge between 2009 and 2012. We use a semiautomated method to trace the observed radiostratigraphy and then derive annual net accumulation rates for 2009–2012. The uncertainty in these radar-derived accumulation rates is on average 14 %. A comparison of the radar-derived accumulation rates and contemporaneous ice cores shows that snow radar captures both the annual and long-term mean accumulation rate accurately. A comparison with outputs from a regional climate model (MAR) shows that this model matches radar-derived accumulation rates in the ice sheet interior but produces higher values over southeastern Greenland. Our results demonstrate that snow radar can efficiently and accurately map patterns of snow accumulation across an ice sheet and that it is valuable for evaluating the accuracy of surface mass balance models. [less ▲]Detailed reference viewed: 29 (0 ULg) Biodistribution of Novel 68Ga-Radiolabelled HER2 Aptamers in MiceGijs, Marlies; Becker, Guillaume ; Plenevaux, Alain et alin Journal of Nuclear Medicine and Radiation Therapy (2016), 7(5), Background: Two novel HER2 aptamers were recently selected with great potential for the in vitro diagnosis of HER2-positive cancer. The goal of this study was to examine the in vivo diagnostic potential ... [more ▼]Background: Two novel HER2 aptamers were recently selected with great potential for the in vitro diagnosis of HER2-positive cancer. The goal of this study was to examine the in vivo diagnostic potential of these HER2 aptamers. Methods: Both HER2 aptamers were radiolabelled with 68Ga, injected in mice bearing a HER2-positive and HER2-negative tumour and evaluated by PET/MRI. Results: Ex vivo bio distribution analysis revealed high uptake in the blood, tissues and organs, except the brain. Interestingly, this high uptake was explained by the slow blood clearance due to non-specific aptamer binding to blood proteins. We observed accumulation of radioactivity in both tumours in time. Although higher uptake in the HER2-positive tumour compared to the HER2-negative tumour was observed, this was accompanied with more necrosis in the HER2-negative tumour, which was observed by 18FDG PET/CT. Conclusion: This work presents a first step towards the development of 68Ga-labelled aptamers for molecular cancer imaging. [less ▲]Detailed reference viewed: 18 (3 ULg) Effectiveness of temporary implants in teenage patients: a prospective clinical trialLAMBERT, France ; BOTILDE, Gaëlle ; LECLOUX, Geoffrey et alin Clinical Oral Implants Research (2016)Abstract Aims: The objective of this study was to assess prospectively the outcomes of extra-narrow diameter implants (XNDI) placed in teenage patients as a temporary restorative option. Material and ... [more ▼]Abstract Aims: The objective of this study was to assess prospectively the outcomes of extra-narrow diameter implants (XNDI) placed in teenage patients as a temporary restorative option. Material and Methods: Twenty consecutive young patients presenting one or several missing teeth received XNDI that were immediately restored with composite, Polymethylmethacrylate (Acrylic) or ceramic crown. Clinical and radiographical outcomes were assessed for a minimum follow-up period of 1 year. Additionally, each patient completed retrospectively a satisfaction questionnaire using Visual Analog Scale (VAS). Results: A total of 30 implants were placed and followed for a period of 1–7.4 years (mean: 3.59 years). One implant failed after 3 weeks and was replaced successfully. No further biological complications occurred during the follow-up period, leading to an implant survival rate of 96.6%. The patient satisfaction evaluations displayed high levels of comfort and function. Conclusion: Immediately restored XNDI to replace missing teeth on teenager patients seems to be an effective temporary restorative option to replace missing teeth in young patients. Composite or ceramic crowns should be preferred. Clinical trials with long-term follow-ups and the assessment of passive egression are needed. [less ▲]Detailed reference viewed: 25 (4 ULg) Honey polyphenols extraction: method development and evidence of cis isomerizationIstasse, Thibaut ; Jacquet, Nicolas ; Berchem, Thomas et alin Analytical Chemistry Insights (2016), 11Honey polyphenols have been studied with the objective of relating honeys to their floral sources. Initially synthesized by plant, these polyphenols can be found in the plant’s nectar, where they are ... [more ▼]Honey polyphenols have been studied with the objective of relating honeys to their floral sources. Initially synthesized by plant, these polyphenols can be found in the plant’s nectar, where they are collected by bees which convert the nectar into honey. Consequently, polyphenols constitute minor honey components. The development of a solid phase extraction method for honey polyphenols is presented herein. The technique employs Amberlite XAD-2 adsorbent and was tested on monofloral honeys from six different plants: acacia, chestnut, eucalyptus, thyme, sunflower and wild carrot. Analyses were performed using high performance liquid chromatography coupled with UV detection and mass spectrometry. Several phenolic acids and flavonoids were identified: caffeic and p-coumaric acids, quercetin, kaempferol, naringenin, chrysin and pinocembrin. Generally, the quantity of a given polyphenol in the honey was around 0.2 mg/100g of honey, except for chestnut honey which contained around 3.0 mg of p-coumaric acid/100g of honey. Analyses highlighted significant formation of cis isomers for phenolic acids during the extraction despite protection from light. [less ▲]Detailed reference viewed: 30 (7 ULg) Ten years of atmospheric methane from ground-based NDACC FTIR observationsBader, Whitney ; Bovy, Benoît ; Conway, S. et alin Atmospheric Chemistry & Physics Discussions (2016), 2016Changes of atmospheric methane (CH4) since 2005 have been evaluated using Fourier Transform Infrared (FTIR) solar observations performed at ten ground-based sites, all members of the Network for Detection ... [more ▼]Changes of atmospheric methane (CH4) since 2005 have been evaluated using Fourier Transform Infrared (FTIR) solar observations performed at ten ground-based sites, all members of the Network for Detection of Atmospheric Composition Change (NDACC). From this, we find an increase of atmospheric methane total columns that amounts to 0.31 ± 0.03 % year-1 (2-sigma level of uncertainty) for the 2005–2014 period. Comparisons with in situ methane measurements at both local and global scales show good agreement. We used the GEOS-Chem Chemical Transport Model tagged simulation that accounts for the contribution of each emission source and one sink in the total methane, simulated over the 2005–2012 time period and based on emissions inventories and transport. After regridding according to NDACC vertical layering using a conservative regridding scheme and smoothing by convolving with respective FTIR seasonal averaging kernels, the GEOS-Chem simulation shows an increase of atmospheric methane of 0.35 ± 0.03 % year-1 between 2005 and 2012, which is in agreement with NDACC measurements over the same time period (0.30 ± 0.04 % year-1, averaged over ten stations). Analysis of the GEOS-Chem tagged simulation allows us to quantify the contribution of each tracer to the global methane change since 2005. We find that natural sources such as wetlands and biomass burning contribute to the inter-annual variability of methane. However, anthropogenic emissions such as coal mining, and gas and oil transport and exploration, which are mainly emitted in the Northern Hemisphere and act as secondary contributors to the global budget of methane, have played a major role in the increase of atmospheric methane observed since 2005. Based on the GEOS-Chem tagged simulation, we discuss possible cause(s) for the increase of methane since 2005, which is still unexplained. [less ▲]Detailed reference viewed: 37 (2 ULg) Greenland Ice sheet [in "State of the Climate in 2015"]Tedesco, M.; Box, J.; Cappelen, J. et alin Bulletin of the American Meteorological Society (2016), 97(8), The Greenland Ice Sheet, with the capacity to contribute ~7 m to sea level rise, experienced melting over more than 50% of its surface for the first time since the record melt of 2012.Detailed reference viewed: 13 (1 ULg) Intercomparison of in-situ NDIR and column FTIR measurements of CO2 at JungfraujochSchibig, M. F.; Mahieu, Emmanuel ; Henne, S. et alin Atmospheric Chemistry and Physics (2016), 16(15), 9935--9949We compare two CO2 time series measured at the High Alpine Research Station Jungfraujoch, Switzerland (3580 m a.s.l.), in the period from 2005 to 2013 with an in situ surface measurement system using a ... [more ▼]We compare two CO2 time series measured at the High Alpine Research Station Jungfraujoch, Switzerland (3580 m a.s.l.), in the period from 2005 to 2013 with an in situ surface measurement system using a nondispersive infrared analyzer (NDIR) and a ground-based remote sensing system using solar absorption Fourier transform infrared (FTIR) spectrometry. Although the two data sets show an absolute shift of about 13 ppm, the slopes of the annual CO2 increase are in good agreement within their uncertainties. They are 2.04±0.07 and 1.97±0.05 ppm yr-1 for the FTIR and the NDIR systems, respectively. The seasonality of the FTIR and the NDIR systems is 4.46±1.11 and 10.10±0.73 ppm, respectively. The difference is caused by a dampening of the CO2 signal with increasing altitude due to mixing processes. Whereas the minima of both data series occur in the middle of August, the maxima of the two data sets differ by about 10 weeks; the maximum of the FTIR measurements is in the middle of January, and the maximum of the NDIR measurements is found at the end of March. Sensitivity analyses revealed that the air masses measured by the NDIR system at the surface of Jungfraujoch are mainly influenced by central Europe, whereas the air masses measured by the FTIR system in the column above Jungfraujoch are influenced by regions as far west as the Caribbean and the USA. The correlation between the hourly averaged CO2 values of the NDIR system and the individual FTIR CO2 measurements is 0.820, which is very encouraging given the largely different sampling volumes. Further correlation analyses showed, that the correlation is mainly driven by the annual CO2 increase and to a lesser degree by the seasonality. Both systems are suitable to monitor the long-term CO2 increase, because this signal is represented in the whole atmosphere due to mixing. [less ▲]Detailed reference viewed: 51 (18 ULg) Major Changes in Growth Rate and Growth Variability of Beech (Fagus sylvatica L.) Related to Soil Alteration and Climate Change in BelgiumLatte, Nicolas ; Perin, Jérôme ; Kint, Vincent et alin Forests (2016), 7(174), Global change—particularly climate change, forest management, and atmospheric deposition—has significantly altered forest growing conditions in Europe. The influences of these changes on beech growth ... [more ▼]Global change—particularly climate change, forest management, and atmospheric deposition—has significantly altered forest growing conditions in Europe. The influences of these changes on beech growth (Fagus sylvatica L.) were investigated for the past 80 years in Belgium, using non-linear mixed effects models on ring-width chronologies of 149 mature and dominant beech trees (87–186 years old). The effects of the developmental stage (i.e., increasing tree size) were filtered out in order to focus on time-dependent growth changes. Beech radial growth was divided into a low-frequency signal (=growth rate), mainly influenced by forest management and atmospheric deposition, and into a high-frequency variability (≈mean sensitivity), mainly influenced by climate change. Between 1930 and 2008, major long-term and time-dependent changes were highlighted. The beech growth rate has decreased by about 38% since the 1950–1960s, and growth variability has increased by about 45% since the 1970–1980s. Our results indicate that (1) before the 1980s, beech growth rate was not predominantly impacted by climate change but rather by soil alteration (i.e., soil compaction and/or nitrogen deposition); and (2) since the 1980s, climate change induced more frequent and intense yearly growth reductions that amplified the growth rate decrease. The highlighted changes were similar in the two ecoregions of Belgium, although more pronounced in the lowlands than in the uplands. [less ▲]Detailed reference viewed: 13 (3 ULg) Estimating the economic impact of a possible equine and human epidemic of West Nile virus infection in BelgiumHumblet, Marie-France ; Vandeputte, Sébastien; Fecher-Bourgeois, Fabienne et alin Eurosurveillance (2016), 21(31), This study aimed at estimating, in a prospective scenario, the potential economic impact of a possible epidemic of WNV infection in Belgium, based on 2012 values for the equine and human health sectors ... [more ▼]This study aimed at estimating, in a prospective scenario, the potential economic impact of a possible epidemic of WNV infection in Belgium, based on 2012 values for the equine and human health sectors, in order to increase preparedness and help decision-makers. Modelling of risk areas, based on the habitat suitable for Culex pipiens, the main vector of the virus, allowed us to determine equine and human populations at risk. Characteristics of the different clinical forms of the disease based on past epidemics in Europe allowed morbidity among horses and humans to be estimated. The main costs for the equine sector were vaccination and replacement value of dead or euthanised horses. The choice of the vaccination strategy would have important consequences in terms of cost. Vaccination of the country’s whole population of horses, based on a worst-case scenario, would cost more than EUR 30 million; for areas at risk, the cost would be around EUR 16–17 million. Regarding the impact on human health, short-term costs and socio-economic losses were estimated for patients who developed the neuroinvasive form of the disease, as no vaccine is available yet for humans. Hospital charges of around EUR 3,600 for a case of West Nile neuroinvasive disease and EUR 4,500 for a case of acute flaccid paralysis would be the major financial consequence of an epidemic of West Nile virus infection in humans in Belgium. [less ▲]Detailed reference viewed: 27 (13 ULg) Environmental factors in autoimmune diseases and their role in multiple sclerosisJörg, Stefanie; Grohme, Diana; Erzler, Melanie et alin Cellular and Molecular Life Sciences : CMLS (2016), 73(24), 4611-4622Detailed reference viewed: 12 (1 ULg) Assessment of the sea-ice carbon pump: Insights from a three-dimensional ocean-sea-ice biogeochemical model (NEMO-LIM-PISCES)Moreau, Sébastien; Vancoppenolle, Martin; Bopp, Laurent et alin Elementa: Science of the Anthropocene (2016), 4(1), 000122The role of sea ice in the carbon cycle is minimally represented in current Earth System Models (ESMs). Among potentially important flaws, mentioned by several authors and generally overlooked during ESM ... [more ▼]The role of sea ice in the carbon cycle is minimally represented in current Earth System Models (ESMs). Among potentially important flaws, mentioned by several authors and generally overlooked during ESM design, is the link between sea-ice growth and melt and oceanic dissolved inorganic carbon (DIC) and total alkalinity (TA). Here we investigate whether this link is indeed an important feature of the marine carbon cycle misrepresented in ESMs. We use an ocean general circulation model (NEMO-LIM-PISCES) with sea-ice and marine carbon cycle components, forced by atmospheric reanalyses, adding a first-order representation of DIC and TA storage and release in/from sea ice. Our results suggest that DIC rejection during sea-ice growth releases several hundred Tg C yr−1 to the surface ocean, of which < 2% is exported to depth, leading to a notable but weak redistribution of DIC towards deep polar basins. Active carbon processes (mainly CaCO3 precipitation but also ice-atmosphere CO2 fluxes and net community production) increasing the TA/DIC ratio in sea-ice modified ocean-atmosphere CO2 fluxes by a few Tg C yr−1 in the sea-ice zone, with specific hemispheric effects: DIC content of the Arctic basin decreased but DIC content of the Southern Ocean increased. For the global ocean, DIC content increased by 4 Tg C yr−1 or 2 Pg C after 500 years of model run. The simulated numbers are generally small compared to the present-day global ocean annual CO2 sink (2.6 ± 0.5 Pg C yr−1 ). However, sea-ice carbon processes seem important at regional scales as they act significantly on DIC redistribution within and outside polar basins. The efficiency of carbon export to depth depends on the representation of surface-subsurface exchanges and their relationship with sea ice, and could differ substantially if a higher resolution or different ocean model were used. [less ▲]Detailed reference viewed: 21 (4 ULg) Replacement of Glycoprotein B in Alcelaphine Herpesvirus 1 by Its Ovine Herpesvirus 2 Homolog : Implications in Vaccine Development for Sheep-Associated Malignant Catarrhal Fever.Cunha, Cristina W.; Taus, Naomi S.; Dewals, Benjamin G et alin mSphere (2016), 1(4), 00108-16Vaccine development is a top priority in malignant catarrhal fever (MCF) research. In the case of sheep-associated MCF (SA-MCF) caused by ovine herpesvirus 2 (OvHV-2), progress toward this objective has ... [more ▼]Vaccine development is a top priority in malignant catarrhal fever (MCF) research. In the case of sheep-associated MCF (SA-MCF) caused by ovine herpesvirus 2 (OvHV-2), progress toward this objective has been hindered by the absence of methods to attenuate or modify the virus, since it cannot be propagated in vitro. As an alternative for vaccine development, in this study, we tested the hypothesis that one of the SA-MCF vaccine candidate targets, OvHV-2 glycoprotein B (gB), could be expressed by a nonpathogenic alcelaphine herpesvirus 1 (AlHV-1) and then evaluated the potential of the AlHV-1/OvHV-2 chimera to be used as a vaccine and a diagnostic tool. The construction and characterization of an AlHV-1/OvHV-2 chimeric virus that is nonpathogenic and expresses an OvHV-2 vaccine target are significant steps toward the development of an SA-MCF vaccine and also provide a valuable means to study OvHV-2 biology. [less ▲]Detailed reference viewed: 16 (2 ULg) Parentification and related processes: distinction and implications for clinical practiceHaxhe, Stéphanie in Journal of Family Psychotherapy (2016), 27(3), 185-199With the emergence of what we call « new families », the place and the role of the child are increasingly questioned. If a child helps a parent or takes care of them, the terms “parentified child” ... [more ▼]With the emergence of what we call « new families », the place and the role of the child are increasingly questioned. If a child helps a parent or takes care of them, the terms “parentified child”, “parental child” or “adult child” are used equally. However, these concepts hide different processes that have different impacts on the child’s development. In the present article, based on our doctoral research and clinical practice experience, we will try to make the distinction between these concepts and to illustrate them. We are convinced that by a better identification of each process, we can help therapists and social workers in their interventions with children and their families. [less ▲]Detailed reference viewed: 41 (5 ULg) LOTUS: a low-cost, ultraviolet spectrographSteele, I. A.; Marchant, J. M.; Jermak, H. E. et alin Monthly Notices of the Royal Astronomical Society (2016), 460We describe the design, construction and commissioning of a simple, low-cost long-slit spectrograph for the Liverpool Telescope. The design is optimized for near-UV and visible wavelengths and uses all ... [more ▼]We describe the design, construction and commissioning of a simple, low-cost long-slit spectrograph for the Liverpool Telescope. The design is optimized for near-UV and visible wavelengths and uses all transmitting optics. It exploits the instrument focal plane field curvature to partially correct axial chromatic aberration. A stepped slit provides narrow (2.5 × 95 arcsec) and wide (5 × 25 arcsec) options that are optimized for spectral resolution and flux calibration, respectively. On sky testing shows a wavelength range of 3200-6300 Å with a peak system throughput (including detector quantum efficiency) of 15 per cent and wavelength dependent spectral resolution of R = 225-430. By repeated observations of the symbiotic emission line star AG Peg, we demonstrate the wavelength stability of the system is <2 Å rms and is limited by the positioning of the object in the slit. The spectrograph is now in routine operation monitoring the activity of comet 67P/Churyumov-Gerasimenko during its current post-perihelion apparition. [less ▲]Detailed reference viewed: 10 (0 ULg) Realization of the Najafi-Golestanian microswimmerGrosjean, Galien ; Hubert, Maxime ; Lagubeau, Guillaume et alin Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2016), 94(2), 021101A paradigmatic microswimmer is the three-linked-spheres model, which follows a minimalist approach for propulsion by shape shifting. As such, it has been the subject of numerous analytical and numerical ... [more ▼]A paradigmatic microswimmer is the three-linked-spheres model, which follows a minimalist approach for propulsion by shape shifting. As such, it has been the subject of numerous analytical and numerical studies. In this Rapid Communication, an experimental three-linked-spheres swimmer is created by self-assembling ferromagnetic particles at an air-water interface. It is powered by a uniform oscillating magnetic field. A model, using two harmonic oscillators, reproduces the experimental findings. Because the model remains general, the same approach could be used to design a variety of efficient microswimmers. [less ▲]Detailed reference viewed: 14 (2 ULg) 2D-photochemical model for forbidden oxygen line emission for comet 1P/HalleyCessateur, G.; De Keyser, J.; Maggiolo, R. et alin Monthly Notices of the Royal Astronomical Society (2016)We present here a 2D-model of photochemistry for computing the production and loss mechanisms of the O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) states, which are responsible for the emission lines at 577.7 nm ... [more ▼]We present here a 2D-model of photochemistry for computing the production and loss mechanisms of the O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) states, which are responsible for the emission lines at 577.7 nm, 630 nm, and 636.4 nm, in case of the comet 1P/Halley. The presence of O[SUB]2[/SUB] within cometary atmospheres, measured by the in-situ ROSETTA and GIOTTO missions, necessitates a revision of the usual photochemical models. Indeed, the photodissociation of molecular oxygen also leads to a significant production of oxygen in excited electronic states. In order to correctly model the solar UV flux absorption, we consider here a 2D configuration. While the green to red-doublet ratio is not affected by the solar UV flux absorption, estimates of the red-doublet and green lines emissions are, however, overestimated by a factor of two in the 1D model compared to the 2D model. Considering a spherical symmetry, emission maps can be deduced from the 2D model in order to be directly compared to ground and/or in-situ observations. [less ▲]Detailed reference viewed: 8 (1 ULg) The 19 Feb. 2016 Outburst of Comet 67P/CG: An ESA Rosetta Multi-Instrument StudyGrün, E.; Agarwal, J.; Altobelli, N. et alin Monthly Notices of the Royal Astronomical Society (2016)On 19 Feb. 2016 nine Rosetta instruments serendipitously observed an outburst of gas and dust from the nucleus of comet 67P/Churyumov-Gerasimenko. Among these instruments were cameras and spectrometers ... [more ▼]On 19 Feb. 2016 nine Rosetta instruments serendipitously observed an outburst of gas and dust from the nucleus of comet 67P/Churyumov-Gerasimenko. Among these instruments were cameras and spectrometers ranging from UV over visible to microwave wavelengths, in-situ gas, dust and plasma instruments, and one dust collector. At 9:40 a dust cloud developed at the edge of an image in the shadowed region of the nucleus. Over the next two hours the instruments recorded a signature of the outburst that significantly exceeded the background. The enhancement ranged from 50% of the neutral gas density at Rosetta to factors >100 of the brightness of the coma near the nucleus. Dust related phenomena (dust counts or brightness due to illuminated dust) showed the strongest enhancements (factors >10). However, even the electron density at Rosetta increased by a factor 3 and consequently the spacecraft potential changed from ˜-16 V to -20 V during the outburst. A clear sequence of events was observed at the distance of Rosetta (34 km from the nucleus): within 15 minutes the Star Tracker camera detected fast particles (˜25 m s[SUP]-1[/SUP]) while 100 μm radius particles were detected by the GIADA dust instrument ˜1 hour later at a speed of ~6 m s[SUP]-1[/SUP]. The slowest were individual mm to cm sized grains observed by the OSIRIS cameras. Although the outburst originated just outside the FOV of the instruments, the source region and the magnitude of the outburst could be determined. [less ▲]Detailed reference viewed: 17 (5 ULg) High selfing rate, limited pollen dispersal and inbreeding depression in the emblematic African rain forest tree Baillonella toxisperma - Management implicationsDuminil, Jérôme; Mendene Abessolo, D. T.; Ndiade Bourobou, D. et alin Forest Ecology & Management (2016), 379Mating system and gene flow are major influencing factors of species population dynamics and evolution. These factors are often not characterized in tropical tree species, yet they constitute basic ... [more ▼]Mating system and gene flow are major influencing factors of species population dynamics and evolution. These factors are often not characterized in tropical tree species, yet they constitute basic information that must be considered to implement sustainable management practices. In particular, as logging implies a reduction of the density of congeneric mates, the connectivity through pollination between individuals has to be well characterized (selfing versus outcrossing rates, distances between mates). We conducted a genetic-based analysis (using 10 nuclear microsatellites) to determine the mating system and gene flow characteristics of an emblematic timber tree species from lowland rain forests of the Congo Basin, Baillonella toxisperma (Sapotaceae). The species, which is frequently exploited for its wood and for a number of non-timber forest products, naturally occurs at low densities (ca. 0.01–0.1 individuals/ha). It is supposedly an entomophilous species whose seeds are probably dispersed by mammals. We have shown that the species presents a mixed-mating system (about 20–40% of selfing depending on analysis method). However, the comparison of inbreeding parameters among cohorts suggests that inbred individuals die between seedling and mature tree stages. The mean pollen dispersal distance was relatively low for such a low-density population species (estimated to be 690 or 777 m depending on analysis method) and, together with a low mean number of pollen donors (NEP = 2.76), it suggests a pattern of nearest-neighbour mating where allo-pollen could be a limiting factor. However, B. toxisperma presents a relatively weak genetic structure (Sp statistic = 0.0095) indicative of long gene dispersal distance (rg = 3–5 km according to the assumed effective population density). Overall, this would indicate that gene flow occurs mainly by extensive seed dispersal in this species. These results suggest that mammals and local populations involved in the dispersal of the species play a key role by lowering biparental inbreeding effects. Sustainable population management might require assisted regeneration using unrelated planting material. [less ▲]Detailed reference viewed: 18 (3 ULg) NdBaScO4 : aristotype of a new family of geometric ferroelectrics?Cochrane, Amber K.; Telfer, Michael; Dixon, Charlotte A. L. et alin Chemical Communications (2016), 52NdBaScO4 represents the aristotype structure of a new series of <110>-cut layered perovskites; it is suggested that compositional fine-tuning is likely to produce a family of new geometric ferro ... [more ▼]NdBaScO4 represents the aristotype structure of a new series of <110>-cut layered perovskites; it is suggested that compositional fine-tuning is likely to produce a family of new geometric ferro- electrics, driven primarily by octahedral tilting. [less ▲]Detailed reference viewed: 10 (2 ULg) Du côté de chez...Godefroid Kurth. Réflexions personnellesGenin, Vincent in Bulletin Trimestriel de l'Institut Archéologique du Luxembourg Arlon (2016), 92(3/4), 99-107Detailed reference viewed: 11 (0 ULg) Impact of vertical and horizontal advection on nutrient distribution in the southeast PacificBarceló-Llull, Barbara; Mason, Evan; Capet, Arthur et alin Ocean Science (2016), 12(4), 1003-1011An innovative approach is used to analyze the impact of vertical velocities associated with quasi-geostrophic (QG) dynamics on the redistribution and uptake of nitrate in the southeast Pacific (SEP). A ... [more ▼]An innovative approach is used to analyze the impact of vertical velocities associated with quasi-geostrophic (QG) dynamics on the redistribution and uptake of nitrate in the southeast Pacific (SEP). A total of 12 years of vertical and horizontal currents are derived from an observation based estimate of the ocean state. Horizontal velocities are obtained through the application of thermal wind balance to weekly temperature and salinity fields. Vertical velocities are estimated by integration of the QG omega equation. Seasonal variability of the synthetic vertical velocity and kinetic energy associated with the horizontal currents is coincident, with peaks in austral summer (November–December) in accord with published observations. The impact of vertical velocity on SEP nitrate uptake rates is assessed by using two Lagrangian particle tracking experiments that differ according to vertical forcing (ω = ωQG vs. ω = 0). From identical initial distributions of nitrate-tagged particles, the Lagrangian results show that vertical motions induce local increases in nitrate uptake reaching up to 30 %. Such increases occur in low uptake regions with high mesoscale activity. Despite being weaker than horizontal currents by a factor of up to 10−4, vertical velocity associated with mesoscale activity is demonstrated to make an important contribution to nitrate uptake, hence productivity, in low uptake regions. [less ▲]Detailed reference viewed: 45 (1 ULg) Guided group purchases of energy renovation services and works in deprived urban neighbourhoodsRuelle, Christine ; Teller, Jacques in Energy Efficiency (2016), 9(4), 861-874The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this ... [more ▼]The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this process. This paper explores the use of a method called ‘Guided Group Purchases’ (GPPs), i.e. an approach combining support, guidance and group purchasing of energy renovation services and works, as a possible method to accelerate the retrofitting of the existing housing stock. It reports on an action research experiment conducted in the context of the Interreg project ‘SUN’ (Sustainable Urban Neighbourhoods). The results of this experiment are quite promising. Within a few months, some 80 energy retrofitting interventions (energy audits or insulation works) were implemented in one neighbourhood of the city of Liège. Our evaluation of the experiment showed that the prospect of achieving cost reductions was one of the main initial expectations of participants to the GGPs. Still the participants rather insisted on other benefits after taking part to the initiative. These benefits were mostly related to the guidance they received, to the facilitation with contractors and to the social dynamics generated by the initiative. Several weaknesses were also identified by participants, like the lack of follow-up during and after the works. Our evaluation also highlighted that the main landlords did not participate in the initiative and that the influence of GGPs on costs was limited to specific types of interventions. Despite observed limitations and possible improvements, such a neighbourhood-based approach certainly constitutes a promising avenue for public authorities to support and accelerate the energy retrofitting of private residential buildings in urban neighbourhoods. [less ▲]Detailed reference viewed: 46 (15 ULg) A general methodology for optimal load management with distributed renewable energy generation and storage in residential housingGeorges, Emeline ; Braun, James; Lemort, Vincent in Journal of Building Performance Simulation [=JBPS] (2016)In the US, buildings represent around 40% of the primary energy consumption and 74% of the electrical energy consumption [U.S. Department of Energy (DOE). 2012. 2011 Buildings Energy Data Book. Energy ... [more ▼]In the US, buildings represent around 40% of the primary energy consumption and 74% of the electrical energy consumption [U.S. Department of Energy (DOE). 2012. 2011 Buildings Energy Data Book. Energy Efficiency & Renewable Energy]. Incentives to promote the installation of on-site renewable energy sources have emerged in different states, including net metering programmes. The fast spread of such distributed power generation represents additional challenges for the management of the electricity grid and has led to increased interest in smart control of building loads and demand response programmes. This paper presents a general methodology for assessing opportunities associated with optimal load management in response to evolving utility incentives for residential buildings that employ renewable energy sources and energy storage. An optimal control problem is formulated for manipulating thermostatically controlled domestic loads and energy storage in response to the availability of renewable energy generation and utility net metering incentives. The methodology is demonstrated for a typical American house built in the 1990s and equipped with a single-speed air-to-air heat pump, an electric water heater and photovoltaic (PV) collectors. The additional potential associated with utilizing electrical batteries is also considered. Load matching performance for on-site renewable energy generation is characterized in terms of percentage of the electricity production consumed on-site and the proportion of the demand covered. For the purpose of assessing potential, simulations were performed assuming perfect predictions of the electrical load profiles. The method also allows determination of the optimal size of PV systems for a given net metering programme. Results of the case study showed significant benefits associated with control optimization including an increase of load matching between 3% and 28%, with the improvement dependent on the net metering tariff and available storage capacity. The estimated cost savings for the consumer ranged from 6.4% to 27.5% compared to no optimization with a unitary buy-back ratio, depending on the available storage capacity. Related reduction in CO2 emissions were between 11% and 46%. Optimal load management of the home thermal systems allowed an increase in the optimal size of the PV system in the range of 13–21%. [less ▲]Detailed reference viewed: 38 (12 ULg) High gene flow between alternative morphs and the evolutionary persistence of facultative paedomorphosisOromi Farrús, Neus ; Michaux, Johan ; Denoël, Mathieu in Scientific Reports (2016), 6Paedomorphosis and metamorphosis are two major developmental processes that characterize the evolution of complex life cycles in many lineages. Whereas these processes were fixed in some taxa, they ... [more ▼]Paedomorphosis and metamorphosis are two major developmental processes that characterize the evolution of complex life cycles in many lineages. Whereas these processes were fixed in some taxa, they remained facultative in others, with alternative phenotypes expressed in the same populations. From a genetic perspective, it is still unknown whether such phenotypes form a single population or whether they show some patterns of isolation in syntopy. This has deep implications for understanding the evolution of the phenotypes, i.e. towards their persistence or their fixation and speciation. Newts and salamanders are excellent models to test this hypothesis because they exhibit both developmental processes in their populations: the aquatic paedomorphs retain gills, whereas the metamorphs are able to colonize land. Using microsatellite data of coexisting paedomorphic and metamorphic palmate newts (Lissotriton helveticus), we found that they formed a panmictic population, which evidences sexual compatibility between the two phenotypes. The high gene flow could be understood as an adaptation to unstable habitats in which phenotypic plasticity is favored over the fixation of developmental alternatives. This makes then possible the persistence of a polyphenism: only metamorphosis could be maintained in case of occasional drying whereas paedomorphosis could offer specific advantages in organisms remaining in water. [less ▲]Detailed reference viewed: 25 (4 ULg) Amphibians breeding in refuge habitats have larvae with stronger antipredator responsesManenti, Raoul; Melotto, Andrea; Denoël, Mathieu et alin Animal Behaviour (2016), 118Antipredator responses are a key determinant of the successful persistence of prey, and behavioural modifications are a frequent antipredator strategy. However, conspecific populations often inhabit ... [more ▼]Antipredator responses are a key determinant of the successful persistence of prey, and behavioural modifications are a frequent antipredator strategy. However, conspecific populations often inhabit heterogeneous environments. This can determine local adaptations, and might also induce variation in antipredator responses. Nevertheless, there is limited information on whether heterogeneity of predation risk among populations determines variation in antipredator response. Here we studied the fire salamander, Salamandra salamandra, a species that can breed in both surface streams and caves, habitats that are predator-rich and predator-free, respectively, and measured differences in antipredator responses across populations with different predation risk. We combined field surveys and laboratory experiments to understand the role of predation risk on the activity patterns of larvae, while measuring behavioural differences between populations. We reared larvae from different habitats in safe and risky conditions and tested their response to predator cues before and after rearing. In the field, predation risk was much higher in surface streams than in caves; larvae moved more in the absence of predators and when the light intensity was low. During laboratory experiments, larvae were less active if reared in risky conditions, but cave larvae showed a stronger response to risk than stream larvae. Therefore, larvae from sites without predators showed higher antipredator responses than those from risky habitats. This response fits the predictions of the risk allocation model, in which prey from habitats with a high background level of risk need to be active even when predators are present, to satisfy their energetic demands. Our findings show that antipredator behaviour may differ strongly between populations and stress the importance of integrating this variability in studies on predatory responses. [less ▲]Detailed reference viewed: 29 (7 ULg) Local modulation of human brain responses by circadian rhythmicity and sleep debtMuto, Vincenzo ; Jaspar, Mathieu ; Meyer, Christelle et alin Science (2016), 351(6300), Detailed reference viewed: 40 (7 ULg) Effects of aging on task- and stimulus-related cerebral attention networksKurth, Sophie ; Majerus, Steve ; Bastin, Christine et alin Neurobiology of Aging (2016), 44Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]Detailed reference viewed: 53 (29 ULg) Stable biofilms of Rhodococcus erythropolis T902.1 in draining pavement structures for runoff water decontaminationMasy, Thibaut ; Bertrand, Christelle ; Paul-Marie, Xavier et alin International Biodeterioration & Biodegradation (2016), 112Permeable Pavement Systems (PPS) are sustainable devices designed to collect, store and treat urban stormwater before its release into the ground. However, this system must sufficiently retain pollutants ... [more ▼]Permeable Pavement Systems (PPS) are sustainable devices designed to collect, store and treat urban stormwater before its release into the ground. However, this system must sufficiently retain pollutants brought by water runoff in order to comply with the current legislation. This study aims at evaluating the implementation in PPS of a hydrocarbonoclastic bacterium, Rhodococcus erythropolis T902.1, in terms of resilience and improvement of the degrading capacity. First results revealed that this strain could durably colonize the different gravels used in the construction of PPS. A 15-month experience in a real parking area showed that this biofilm remained viable without any replenishment of nutrients or bacteria. During accelerated pollution tests at a pilot scale, the structure bioaugmented with pre-coated biofilms was more efficient than a non-inoculated structure to limit hydrocarbon leaching below 50 μg L−1 and to degrade hydrocarbons adsorbed to the gravels. Over the long term, this innovative assembly should maintain the degrading capacity of PPS and ensure an effective treatment of stormwater before its infiltration into the soil. [less ▲]Detailed reference viewed: 26 (9 ULg) Monitoring of anatabine release by methyl jasmonate elicited BY-2 cells using surface-enhanced Raman scatteringDe Bleye, Charlotte ; Dumont, Elodie ; Dispas, Amandine et alin Talanta (2016), 160A new application of surface-enhanced Raman scattering (SERS) in the field of plant material analysis is proposed in this study. The aim was to monitor the release of anatabine by methyl jasmonate (MeJa ... [more ▼]A new application of surface-enhanced Raman scattering (SERS) in the field of plant material analysis is proposed in this study. The aim was to monitor the release of anatabine by methyl jasmonate (MeJa) elicited Bright Yellow-2 (BY-2) cells. Gold nanoparticles (AuNps) were used as SERS substrate. The first step was to study the SERS activity of anatabine in a complex matrix comprising the culture medium and BY-2 cells. The second step was the calibration. This one was successfully performed directly in the culture medium in order to take into account the matrix effect, by spiking the medium with different concentrations of anatabine, leading to solutions ranging from 250 to 5000 µg L-1. A univariate analysis was performed, the intensity of a band situated at 1028 cm-1, related to anatabine, was plotted against the anatabine concentration. A linear relationship was observed with a R2 of 0.9951. During the monitoring study, after the MeJa elicitation, samples were collected from the culture medium containing BY-2 cells at 0, 24h, 48h, 72h and 96h and were analyzed using SERS. Finally, the amount of anatabine released in the culture medium was determined using the response function, reaching a plateau after 72h of 82 µg of anatabine released / g of fresh weight (FW) MeJa elicited BY-2 cells. [less ▲]Detailed reference viewed: 36 (14 ULg) Release of cardiac biomarkers during a cycling raceLE GOFF, Caroline ; Kaux, Jean-François ; D'OTREPPE DE BOUVETTE, Stéphanie et alin World Journal of Cardiovascular Diseases (2016), 6(8), 285-294Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aim to see if the relatively ... [more ▼]Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aim to see if the relatively cardiospecific biomarkers could show the damage on cardiac muscle cells. Methods: Fourteen cyclists were recruited for an international race (177km). We studied the release of injury related cardiac markers, risk related cardiac markers, renal function markers and blood cytology. The subjects were submitted to three blood test: one before (T0), one just after (T1) and the last one 3 hours after the race (T3). Results: Blood cytology markers, namely erythrocytes, hemoglobin, hematocrit, and average hemoglobin concentration, were found to evolve in a similar way. Renal function markers, such as creatinin, cystatin C and uric acid, showed a post effort increase that might be related to renal blood flow depletion during exercise. Cardiac and muscular markers were all increased at T1. Conclusions: Physiological stress induced by an international cycling race certainly has consequences on cardiac muscle cells. Fortunately, those blood concentration variations are more representative of a transitional state, due to an imbalance created by an intense aerobic effort maintained during several hours, rather than an irreversible injury. [less ▲]Detailed reference viewed: 14 (3 ULg) Laser optics in space failure risk due to laser induced contaminationKokkinos, Dimitrios ; Schroeder, Helmut; Fleury-Frenette, Karl et alin CEAS Space Journal (2016), 8Detailed reference viewed: 21 (3 ULg) Statistically Bundled Shewhart Control Charts for Monitoring Delivery Chains SystemsFoster, Earnest; Faraz, Alireza ; Heuchenne, Cédric in European Journal of Industrial Engineering (2016)Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the ... [more ▼]Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the proposed method is to provide supply chain decision makers with an easy to be managed tool monitoring the current functioning state of the delivery chain. The implementation of SPC control charts makes it possible to limit over-corrections to false alarm conditions and to maintain at an acceptable level the safety stock, with a consequent reduction of the overall management costs of the delivery chain. An illustrative example shows the proposed control chart implementation in a real delivery chain. [less ▲]Detailed reference viewed: 84 (2 ULg) Horner syndrome in children: a clinical condition with serious underlying diseaseBarrea, Christophe ; Vigouroux, Tiphaine ; Karam, Joe et alin Neuropediatrics (2016), 47(4), 268-272Detailed reference viewed: 17 (3 ULg) Les cuvettes oasiennes du Niger oriental: entre pratiques foncières et cadre législatifMalam Boukar, Awa Krou; Yamba, Boubacar; Andres, Ludovic et alin Revue Internationale des Sciences de Développement (2016), 4(6), 376-388Despite the new context of the land-law with the land committee, the property owner depends on the traditional law. This paper shows the land system in the south east of the Niger. Nine basin oasis have ... [more ▼]Despite the new context of the land-law with the land committee, the property owner depends on the traditional law. This paper shows the land system in the south east of the Niger. Nine basin oasis have selected in function of the food system and the proof of the phreatic table. An investigation with 105 producters has showed the description and the analysis of the land access and the conflicts. The analysis shows the strong influence of traditional authorities and the lack of operationalization of COFOB. Finally, the conflicts are generalized between many actors (farmers, pastoralists and agro-pastoralists) and settlement is done mainly by conciliation. Furthermore, the disparity between the men and the women land access is very important. [less ▲]Detailed reference viewed: 24 (5 ULg) The future impacts on downstream communities: A case study of the multipurpose Nam Mang 3 hydropower Project in Lao PDRKouangpalath, Phimthong ; Lebailly, Philippe ; Ducourtieux, Olivierin Sky Journal of Agricultural Research (2016), 5(6), 105-128Considering future projects, this paper examines the effects of hydropower dam projects on downstream communities. This study was conducted in the multi-purpose hydropower and irrigated areas of the Nam ... [more ▼]Considering future projects, this paper examines the effects of hydropower dam projects on downstream communities. This study was conducted in the multi-purpose hydropower and irrigated areas of the Nam Mang 3 hydropower. Using a survey study with various stakeholders, household survey, several interviews were held with key informants in addition to field work observation. It was determined that this project has caused a number of negative impacts on farmers, especially those in downstream areas, directly concerned water releases from dam and affecting the benefits from irrigation. The main findings show that farmers are able to grow a second season of rice crops, but the electricity generated in the rainy season from the dam leads to the rice fields flooding along the downstream areas. [less ▲]Detailed reference viewed: 40 (10 ULg) Relationship between frailty, physical performance and quality of life among nursing home residents: the SENIOR cohortBuckinx, Fanny ; Reginster, Jean-Yves ; Petermans, Jean et alin Aging Clinical and Experimental Research (2016), Epub ahead of printBackground The aim of this study was to assess the relationship between frailty and a large number of indicators related to physical and muscular performance as well as quality of life. Methods This is an ... [more ▼]Background The aim of this study was to assess the relationship between frailty and a large number of indicators related to physical and muscular performance as well as quality of life. Methods This is an analysis of data collected at baseline in the Sample of Elderly Nursing home Individuals: an Observational Research (SENIOR) cohort including nursing home residents. Subjects are volunteer, oriented and able to walk (walking assistance allowed) nursing home residents in Belgium. A large number of demographic and clinical characteristics, including physical and muscular performance, were collected from each patient. The prevalence of frailty in this population was assessed using Fried’s definition. Results In total, 662 subjects are included in this analysis. The mean age of the sample is 83.2 ± 8.99 years, and 484 (73.1 %) are women. In this population of nursing home residents, the prevalence of frailty is 25.1 %, pre-frailty, 59.8 % and robustness, 15.1 %. Compared to non-frail subjects, frail subjects have lower physical and muscular performances and a lower quality of life. Conclusion Frailty, according to Fried’s definition, seems to be associated with several clinical indicators suggesting a higher level of disability and an increased propensity to develop major clinical consequences. Follow-up data of the SENIOR cohort will be helpful in confirming these findings, establishing cause–effect relationships and identifying the most predictive components of physical frailty for adverse outcomes in nursing homes. [less ▲]Detailed reference viewed: 14 (8 ULg) Hydrocarbon biostimulation and bioaugmentation in organic carbon and clay-rich soilsMasy, Thibaut ; Demanèche, Sandrine; Tromme, Olivier et alin Soil Biology & Biochemistry (2016), 99Hydrocarbon-contaminated organic carbon-rich clayey soils are challenging for bioremediation stakeholders since the pollutant is heterogeneously distributed and poorly bioavailable due to its strong ... [more ▼]Hydrocarbon-contaminated organic carbon-rich clayey soils are challenging for bioremediation stakeholders since the pollutant is heterogeneously distributed and poorly bioavailable due to its strong adsorption on clay and organic particles. In addition, biodegradation rates are restricted by limited diffusion of oxygen and nutrients to hydrocarbon-degrading aerobes. This study assessed the benefits of bioaugmentation with the strain Rhodococcus erythropolis T902.1 versus those from biostimulation and anaerobic natural attenuation in terms of hydrocarbon (HC) degradation efficiency and changes in the bacterial community structure in a diesel-polluted clay-rich soil. Three soil samples with a similar total organic content but with a different HC concentration (0.2, 1.0 and 6.5 g/kg) were compared in a microcosm experiment. Despite a limitation in oxygen transfer, R. erythropolis T902.1 enhanced a greater HC degradation compared to the biostimulation treatment. However, this advantage decreased with time as the proportion of Rhodococci declined from 25% initially to 1% of the global community after 80 days of treatment. Similarly, the alkB gene proportion in bioaugmented soils decreased to levels close to those of biostimulated soils. Consequently, further engineering was suggested to improve the resilience of the inoculum to ensure its long-term presence and activity in such polluted environments. [less ▲]Detailed reference viewed: 48 (7 ULg) Longterm results of liver transplantation from donation after circulatory death.Blok, Joris J.; DETRY, Olivier ; Putter, Hein et alin Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2016), 22(8), 1107-14Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic-type ... [more ▼]Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic-type biliary lesions. However, similar survival rates for DCD and donation after brain death (DBD) LT have been reported. The objective of this study is to determine the longterm outcome of DCD LT in the Eurotransplant region corrected for the Eurotransplant donor risk index (ET-DRI). Transplants performed in Belgium and the Netherlands (January 1, 2003 to December 31, 2007) in adult recipients were included. Graft failure was defined as either the date of recipient death or retransplantation whichever occurred first (death-uncensored graft survival). Mean follow-up was 7.2 years. In total, 126 DCD and 1264 DBD LTs were performed. Kaplan-Meier survival analyses showed different graft survival for DBD and DCD at 1 year (77.7% versus 74.8%, respectively; P = 0.71), 5 years (65.6% versus 54.4%, respectively; P = 0.02), and 10 years (47.3% versus 44.2%, respectively; P = 0.55; log-rank P = 0.038). Although there was an overall significant difference, the survival curves almost reach each other after 10 years, which is most likely caused by other risk factors being less in DCD livers. Patient survival was not significantly different (P = 0.59). Multivariate Cox regression analysis showed a hazard ratio of 1.7 (P < 0.001) for DCD (corrected for ET-DRI and recipient factors). First warm ischemia time (WIT), which is the time from the end of circulation until aortic cold perfusion, over 25 minutes was associated with a lower graft survival in univariate analysis of all DCD transplants (P = 0.002). In conclusion, DCD LT has an increased risk for diminished graft survival compared to DBD. There was no significant difference in patient survival. DCD allografts with a first WIT > 25 minutes have an increased risk for a decrease in graft survival. Liver Transplantation 22 1107-1114 2016 AASLD. [less ▲]Detailed reference viewed: 12 (2 ULg) Postmortem Internal Gas Reservoir Monitoring Using GCxGC-HRTOFMSStefanuto, Pierre-Hugues ; Perrault, Katelynn ; Grabher, Silke et alin separations (2016), 3(24), Forensic investigations often require postmortem examination of a body. However, the collection of evidence during autopsy is often destructive, meaning that the body can no longer be examined in its ... [more ▼]Forensic investigations often require postmortem examination of a body. However, the collection of evidence during autopsy is often destructive, meaning that the body can no longer be examined in its original state. In order to obtain an internal image of the body, whole body postmortem computed tomography (PMCT) has proven to be a valuable non-destructive tool and is currently used in medicolegal centers. PMCT can also be used to visually locate gas reservoirs inside a cadaver, which upon analysis can provide useful information regarding very volatile compounds that are produced after death. However, the non-targeted profiling of all potential volatile organic compounds (VOCs) present in these reservoirs has never been attempted. The aim of this study was to investigate the VOC profile of these reservoirs and to evaluate potential uses of such information to document circumstances surrounding death, cause of death and body taphonomy. Comprehensive two-dimensional gas chromatography coupled to time-of-flight high-resolution mass spectrometry (GC GC-HRTOF-MS) was used for VOC measurements. This study demonstrated that the chemical composition of VOCs within the gas reservoirs differed between locations within a single body but also between individuals. In the future, this work could be expanded to investigate a novel, non-destructive cadaver screening approach prior to full autopsy procedures. [less ▲]Detailed reference viewed: 16 (2 ULg) Computational modelling of local calcium ions release from calcium phosphate-based scaffoldsManhas, Varun ; Guyot, Yann; Kerckhofs, Greet et alin Biomechanics & Modeling in Mechanobiology (2016)Detailed reference viewed: 11 (1 ULg) Interfascial spread of injectate after adductor canal injection in fresh human cadaversGOFFIN, Pierre ; LECOQ, Jean-Pierre ; NINANE, Vincent et alin Anesthesia and Analgesia (2016), 123(2), 501-503Detailed reference viewed: 18 (2 ULg) Automatic learning of fine operating rules for online power system security controlSun, Hongbin; Zhao, Feng; Wang, Huifang et alin IEEE Transactions on Neural networks and learning systems (2016), 27(8), 1708-1719Fine operating rules for security control and an automatic system for their online discovery were developed to adapt to the development of smart grids. The automatic system uses the real-time system state ... [more ▼]Fine operating rules for security control and an automatic system for their online discovery were developed to adapt to the development of smart grids. The automatic system uses the real-time system state to determine critical flowgates, and then a continuation power flow-based security analysis is used to compute the initial transfer capability of critical flowgates. Next, the system applies the Monte Carlo simulations to expected short-term operating condition changes, feature selection, and a linear least squares fitting of the fine operating rules. The proposed system was validated both on an academic test system and on a provincial power system in China. The results indicated that the derived rules provide accuracy and good interpretability and are suitable for real-time power system security control. The use of high-performance computing systems enables these fine operating rules to be refreshed online every 15 min. [less ▲]Detailed reference viewed: 65 (4 ULg)