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See detailOn the residual advection of passive constituents
Delhez, Eric ULg

in Journal of Marine Systems (1996), 8(3-4), 147-169

In this paper, the different approaches used to simulate the long-term advection of passive constituents on tidal shelves are discussed in the framework of large scale hydrodynamic modelling. The direct ... [more ▼]

In this paper, the different approaches used to simulate the long-term advection of passive constituents on tidal shelves are discussed in the framework of large scale hydrodynamic modelling. The direct approach in which the unsteady mesoscale (tides and storm surges) and macroscale (monthly or seasonal mean processes) currents are used is very demanding in computer resources (CPU and memory). On the other hand, the use of residual velocities gives a larger understanding of the long-term transport processes and simplifies numerical treatments. However, the definition of such appropriate velocities is still an open question. In the context of large scale models, Lagrangian residuals are not applicable. Eulerian residual transport velocities fail to represent long-term motions when tidal non-linearities are important. The first order Lagrangian residual velocity introduced by Feng et al. (1986a) and generalized here is shown to be a very good solution. The North-Western European Continental Shelf (NWECS) is used as an example to compare the numerical solutions obtained with the different approaches. [less ▲]

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See detailAu-delà du principe de répétition
Gauthier, Jean-Marie ULg

in Revue Belge de Psychanalyse (1996), 28

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See detailImpact of the microbiology in the epuration processes.
Thonart, Philippe ULg; Destain, Jacqueline ULg; Antoine, Patrice et al

in Cerevisia and Biotechnology (1996), 21(2), 76-79

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at ... [more ▼]

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at very low concentrations of pollutants. Two approaches can be considered for developing biological processes of epuration : addition of bioactivators for improving endogenous microorganisms capabilities or introduction of microorganism starters for accelerating the epuration process. These two ways need as prerequisite a basic knowledge of the metabolic pathways for specific compound degradation and of microbial ecology [less ▲]

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See detailLipid-binding properties of synthetic peptide fragments of human apolipoprotein A-II.
Benetollo, C.; Lambert, Géraldine ULg; Talussot, C. et al

in European Journal of Biochemistry (1996), 242(3), 657-64

Human apolipoprotein A-II (apo A-II) consists of three potential amphipathic helices of 17 residues each, which contribute to the lipid-binding properties of this apolipoprotein. The conformation and ... [more ▼]

Human apolipoprotein A-II (apo A-II) consists of three potential amphipathic helices of 17 residues each, which contribute to the lipid-binding properties of this apolipoprotein. The conformation and lipid-binding properties of these peptides, either as single-helix or as two-helix peptides, were investigated by turbidity, fluorescence, electron-microscopy and circular-dichroism measurements, and are compared in this article. The lipid affinity of shorter C-terminal segments of apo A-II was compared with those of the single-helix or two-helix peptides, to define the minimal peptide length required for stable complex formation. The properties of the apo-A-II-(13-48)-peptide were further compared with those of the same segment after deletion of the Ser31 and Pro32 residues, because the deleted apo-A-II-(13-30)-(33-48)-peptide, is predicted to form a long uninterrupted helix. The single helices of apo A-II could not form stable complexes with phospholipids, and the helix-turn-helix segment spanning residues 13-48 was not active either. The apo-A-II-(37-77)-peptide and the apo-A-II-(40-73)-peptide could form complexes with lipids, which appear as discoidal particles by negative-staining electron microscopy. The shortest C-terminal domain of apo A-II able to associate with lipids to form stable complexes was the apo-A-II-(40-73)-peptide, which consisted of the C-terminal helix, a beta-turn and part of the preceding helix. The shorter apo-A-II-(49-77)-peptide, and the helical apo-A-II-(13-30)-(33-48)-peptide, could also associate with phospholipids. The complexes formed were, however, less stable, as they dissociated outside the transition temperature range of the phospholipid. These data suggest that the C-terminal pair of helices of apo A-II, which is the most hydrophobic pair, is responsible for the lipid-binding properties of the entire protein. The N-terminal pair of helices of apo A-II at residues 13-48 does not associate tightly with lipids. The degree of internal similarity and the cooperativity between the helical segments of apo A-II is thus less pronounced than in apo A-I or apo A-IV. The N-terminal and C-terminal domains of apo A-II appear to behave as two distinct entities with regard to lipid-protein association. [less ▲]

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See detailUsefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study.
Daubresse, Jean-Claude; Kolanowski, J.; Krzentowski, G. et al

in Obesity Research (1996), 4(4), 391-6

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent ... [more ▼]

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent diabetics, moderately obese (BMI = 30 - 39 kg/m2), were given for an 8-week period either placebo (P) or fluoxetine (F), a specific serotonin reuptake inhibitor, in addition to their usual antidiabetic treatment. Thirty-nine of them received 60 mg fluoxetine a day and 43 were given the placebo. At admission, both groups had similar weight excess, metabolic control and serum lipid values. In comparison with the P-treated subjects, those treated with fluoxetine (F) lost more weight after 3 weeks (-1.9 vs. -0.7 kg, p < -0.0009) and after 8 weeks (-3.1 vs. -0.9 kg, p < 0.0007). Fasting blood glucose decreased in group F after 3 weeks (-1.5 vs -0.4 mmol/L, p < 0.003) and after 8 weeks (-1.7 vs. -0.02 mmol/L, p < 0.0004). HbAlc decreased from 8.5% to 7.7% in group F and from 8.6% to 8.3% in group P (p = 0.057). Mean triglyceride level was also reduced in group F after 8 weeks (p = 0.042). Fasting C-peptide did not change in either group, but fasting insulin values decreased in group F after 3 weeks (p < 0.02) and after 8 weeks (p < 0.05). The insulin/C-peptide molar ratio decreased significantly in group F after 3 weeks (p < 0.04) and after 8 weeks (p < 0.05) in comparison with group P. The drug was generally well tolerated and no major side effects were reported. In conclusion, the addition of fluoxetine to the usual oral hypoglycemic agent therapy might be beneficial in obese non-insulin-dependent diabetics, at least on a short-term basis. [less ▲]

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See detailInsulin action in man.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1996), 22(2), 105-10

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is ... [more ▼]

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues and for the prevention of excessive gluconeogenic substrate production. Various methods have been developed to assess insulin action in vivo, essentially at liver and muscle sites. Such methods evaluate the effect of exogenous or endogenous insulin, using respectively the open-loop approach (interruption of the feedback loop by inhibiting endogenous insulin secretion) or the closed-loop approach (mathematical modelling of the insulin-glucose feedback loop). Knowledge of the successive steps of cellular insulin action has markedly improved during the last ten years. Preceptor, receptor and postreceptor levels need to be considered since they may be affected in insulin-resistant states. This general progress in the understanding of insulin action in man improves our approach to the complex pathophysiology of non-insulin-dependent diabetes mellitus and opens up new prospects for treatment of the insulin-resistant syndrome which is associated with several atherosclerotic risk factors. [less ▲]

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See detailVers une perspective transactionnelle du stress au travail : pistes d'évaluations méthodologiques
De Keyser, Véronique ULg; Hansez, Isabelle ULg

in Cahiers de Médecine du Travail (1996), 33(3), 133-144

L'objectif principal de cet article est d'élaborer des pistes d'évaluations méthodologiques pour les études sur le stress au travail. L'approche se base sur une définition du stress axée sur le contrôle ... [more ▼]

L'objectif principal de cet article est d'élaborer des pistes d'évaluations méthodologiques pour les études sur le stress au travail. L'approche se base sur une définition du stress axée sur le contrôle de la situation et adopte une conception transactionnelle du stress psychologique au travail insistant sur l'importance de l'évaluation de la situation par l'individu et les processus de coping, dans une perspective diachronique (Mackay et Cooper, 1987). Cet article synthétise les indices utilisés généralement dans les recherches sur le stress au travail et discute leurs limites. Les problèmes méthodologiques envisagés sont les suivants: la difficulté d'établir des relations causales, les problèmes de validité discriminante et convergente, la mise en évidence des effets de chronicité, la fidélité des mesures. Des suggestions sont alors proposées, basées principalement sur une démarche combinant comparaisons intra et inter-individuelles, la méthode des «critical job events» ou approche épidémiologique, les stratégies de triangulation, le tout dans une perspective longitudinale. Pour terminer, des exemples en milieu hospitalier illustrent les démarches proposées. [less ▲]

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See detailPratiques d'auto-formation : une enquête en communauté française de Belgique
Denis, Brigitte ULg

in Cahiers d'Etudes du C U E E P (1996), 32-33

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See detailSeasonal temperature and salinity fields in the Mediterranean Sea: Climatological analyses of a historical data set
Brasseur, P.; Beckers, Jean-Marie ULg; Brankart, J. M. et al

in Deep-Sea Research Part I, Oceanographic Research Papers (1996), 43(2), 159-192

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly ... [more ▼]

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly distributions of hydrographic properties have been computed by a variational inverse method as an alternate to the standard Gandin (1969; Objective analysis of meterological fields, Israeli Program for Scientific Translation, Jerusalem) procedure. The spline solutions of the minimization problem are demonstrated to be numerically and theoretically equivalent to field estimates obtained by conventional objective analysis. The application of a finite-element technique allows analysis to be performed in the model space rather than in the observational space, which substantially improves the numerical efficiency of the procedure. The parameters of the scheme are adjusted according to the statistics of the climatological data. The results,realized as gridded data sets (horizontal resolution of 0.25 degrees), show some trends in seasonal variability affecting the properties of water masses. As expected, the upper layer is subject to a well-defined seasonal signal affecting both the temperature and salinity fields. Error maps, reflecting the degree of uncertainty in the analyses, have been systematically produced. The present work is conceived as a basic support to more advanced studies such as diagnostic calculations, initialization of dynamical models, assimilation of hydrological data into primitive equation models, or planning of experimental surveys. New versions of the climatological fields will be released as data are added to the historical data base. Copyright (C) 1996 Elsevier Science Ltd. [less ▲]

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See detailLes reliques sur ordinateur
George, Philippe ULg

in Le médiéviste et l'ordinateur (1996)

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See detailSuperconductivity fluctuation effects on the thermal conductivity of Bi2Sr2CaCu2O8
Houssa, M.; Bougrine, Hassan ULg; Stassen, S. et al

in Physical Review. B : Condensed Matter (1996), 54(10), 6885-6888

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional ... [more ▼]

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional (2D) to 3D behavior theoretically predicted by Varlamov and Livanov is well marked. The crossover temperature T-VL and the amplitude of the fluctuation contribution lead to realistic values for the interlayer coupling energy J(C) and the transport relaxation time tau near T-c. [less ▲]

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See detailRelationships between sleep quality and glucose regulation in normal humans.
Scheen, André ULg; Byrne, M. M.; Plat, L. et al

in American Journal of Physiology (1996), 271(2 Pt 1), 261-70

To define the effects of sleep on glucose regulation, we analyzed plasma glucose levels, insulin secretion rates (ISR), and plasma growth hormone and cortisol levels in normal subjects receiving a ... [more ▼]

To define the effects of sleep on glucose regulation, we analyzed plasma glucose levels, insulin secretion rates (ISR), and plasma growth hormone and cortisol levels in normal subjects receiving a constant glucose infusion during nocturnal sleep, nocturnal sleep deprivation, and daytime recovery sleep. Plasma glucose and ISR markedly increased during early nocturnal sleep and returned to presleep levels during late sleep. These changes in glucose and ISR appeared to reflect the predominance of slow-wave (SW) stages in early sleep and of rapid-eye-movement and wake stages in late sleep. Major differences in glucose and ISR profiles were observed during sleep deprivation as glucose and ISR remained essentially stable during the first part of the night and then decreased significantly, despite the persistence of bed rest and constant glucose infusion. During daytime recovery sleep, SW stages were increased, glucose levels peaked earlier than during nocturnal sleep, and the decreases of glucose and ISR in late sleep were reduced by one-half. Thus sleep has important effects on brain and tissue glucose utilization, suggesting that sleep disturbances may adversely affect glucose tolerance. [less ▲]

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See detailL’expérience du SEGEFA en géographie appliquée
Merenne-Schoumaker, Bernadette ULg

in Géographes Associés (1996), (19), 25-29

Presentation and critical analysis of the experience in applied geography SEGEF

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See detailModélisation en hydrogéologie - De modelisatie in de hydrogeologie
Dassargues, Alain ULg; Vander Velpen, B.; Vercruysse, J.

in BLUG Tijdschrift - Revue de l'UBLG (1996)

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See detailSexual differentiation of odor and partner preference in the rat.
Bakker, Julie ULg; Van Ophemert, J.; Slob, A. K.

in Physiology & Behavior (1996), 60(2), 489-94

Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an ... [more ▼]

Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an altered sexual partner preference. When tested in a three-compartment box, such gonadally intact ATD males approach and mate both with the estrous female and the sexually active male, whereas normal males prefer to approach and mate with the estrous female, avoiding the stimulus male. After castration in adulthood and estradiol treatment, ATD males prefer sexually active males. Similarly treated normal males prefer estrous females, and estrous females prefer to mate with males. In the present study, we asked what stimulus characteristics of active males vs. estrous females determined the different sexual preferences of males, ATD males, and of females. Were they chemosensory cues or more distal cues such as actually seeing and hearing the stimulus animals or the reward of sexual activity with the stimulus animals? Sex differences in preference were evident when animals were given a choice between soiled bedding from estrous females and from sexually active males. ATD and control males spent significantly more time on soiled bedding from estrous females than on soiled bedding from sexually active males. Control females spent significantly more time on soiled bedding from sexually active males than on soiled bedding from estrous females. More distal cues, such as seeing and hearing the stimulus animals, revealed differences in preference between control males and females, but not between ATD and control males. Physical interaction with the stimulus animals was a prerequisite for revealing differences in preference between ATD and control males. Then, the behavior of ATD males was clearly intermediate between that of normal male and female rats. In conclusion, neonatal estradiol is important for the psychosexual development of the male rat. However, the present data suggest that the psychosexual development of the male rat also requires either prenatal estradiol or perinatal testosterone. [less ▲]

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See detailBiodegradable and macroporous polylactide implants for cell transplantation : 1. Preparation of macroporous polylactide supports by solid-liquid phase separation
Schugens, Ch; Maquet, Véronique; Grandfils, Christian ULg et al

in Polymer (1996), 37(6), 1027-1038

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing ... [more ▼]

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing and formulation parameters. The effects of polymer concentration, chain stereoregularity, polymer molecular weight and cooling rate have been investigated in connection with the porous morphology and the physico-mechanical characteristics of the final foams. As a rule, bundles of channels are formed with a diameter of ~100 μ.m. They have a preferential orientation that fits the cooling direction. A porous substructure (~10 μm) is observed in the internal walls of the tubular macropores. Variations in this general porous morphology-and particularly in the porosity, density, solvent residue, mechanical resistance and degree of regularity in the spatial organization of pores-have been observed when polymer concentration in 1,4-dioxane and polylactide stereoregularity are changed. As expected, cooling rate has a strong effect on the foam morphology, which is essentially controlled by the solvent crystallization. Pores are nothing but the fingerprints of 1,4-dioxane crystallites. [less ▲]

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See detailLa thermographie infrarouge dans l'étude de la thermorégulation chez le cheval : effets de l'entraînement
Ghafir, Y.; Art, Tatiana ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of ... [more ▼]

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of measurements of rectal and skin temperature. The results have shown a smaller increase of rectal temperature and a greater increase of cutaneous temperature following a training period of 6 weeks. They suggest an improvement of thermoregulation via the skin. [less ▲]

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See detailOpera Latina, le CD-ROM de textes latins classiques du LASLA
Purnelle, Gérald ULg

in Le Médiéviste et l’Ordinateur (1996), 33(printemps), 21-25

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See detailThe efficacy in vitro and in vivo of bacteriocin against Erwinia amylovora : comparison of biological and chemical control of fire blight
Jabrane, A.; Deckers, T.; Ledoux, L. et al

in Acta Horticulturae (1996), 411

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See detailHistological and biometrical study of intraovarian oocytes in barbel (Barbus barbus) reared in captivity
Poncin, Pascal ULg; Thiry, Marc ULg; Lepoint, A. et al

in Folia Zoologica (1996), 45(Suppl. 1), 117-

In the present study, we investigated the histology and oocyte size variations in ovaries from barbel reared in captivity. We demonstrated that the size distribution of intraovarian oocytes is quadrimodal ... [more ▼]

In the present study, we investigated the histology and oocyte size variations in ovaries from barbel reared in captivity. We demonstrated that the size distribution of intraovarian oocytes is quadrimodal (including primary oocytes, oocytes with vacuoles, vitellogenetic oocytes and ova), Indicating that oocyte development can be found in the ovaries (some oocytes are in late vitellogenesis). The ovarian structure is discussed in realation to the repeated spawnings observed in captivity. [less ▲]

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See detailThermographic facial pattern following an alpha2-adrenergic agonist injection in two horses suffering from Horner's syndrome
Ghafir, Y.; Art, Tatiana ULg; Lekeux, Pierre ULg

in Equine Veterinary Education (1996), 8(4), 192-195

The objective of the present study was to confirm this latter assumption, by measuring the facial skin temperature by infrared thermography after administration of an alpha2-adrenergic agonist to horses ... [more ▼]

The objective of the present study was to confirm this latter assumption, by measuring the facial skin temperature by infrared thermography after administration of an alpha2-adrenergic agonist to horses suffering from HS. [less ▲]

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See detailGaston Leroux et la dissociation de la matière romanesque
Denis, Benoît ULg

in Tapis-franc. Revue du roman populaire (1996), (7), 56-66

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See detailRéactions physiologiques face à des conditions extrêmes de chaleur et d'humidité relative. Etude de la récupération après l'exercice
Art, Tatiana ULg; Votion, Dominique ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (1996), 28

The purpose of this study was to follow the recovery of horses during 1hour after treadmill exercise performed either in temperated atmospheric conditions (TC) (ambient temperature: 15°C; relative ... [more ▼]

The purpose of this study was to follow the recovery of horses during 1hour after treadmill exercise performed either in temperated atmospheric conditions (TC) (ambient temperature: 15°C; relative humidity: 55%) or in hot and humid conditions (HHC) (ambient temperature: 30°C; relative humidity: 75%). Five healthy fit standardbred horses (493± 14 kg; 4± 0,5 yrs) were investigated twice at eight days interval, in TC and in HHC. Some ventilatory and cardiorespiratory measurements were made during a standardised treadmill exercise test (SET), other measurements, i.e. cardiac and respiratory frequencies and rectal temperature, during a 1-hour recovery period. The SET consisted in 8 min warm-up and in 8 min exercise (1 min at 1,7, 4, 7, 8, 9 and 10 m/sec and 2 min at 4 m/sec with a 6% (3.4°) slope). Venous blond was sampled before, 2 min, 60 min and 48 hours after the completion of the test for biochemical analysis, namely plasma electrolytes and enzymatic activities. Exercising in HHC induced a reduction of the aerobic metabolism to the total energy requierement, i.e. a 20 % decrease of VO, and 55 % increase in lactate, as well as a decrease in VE. The increase in rectal and skip temperature, the dehydration and the weight loss were higher in HHC than in TC. During the recovery period the HR and f remained higher up to 30 minutes after the end of the SET in HHC while the rectal temperature remained higher up to 60 min after the end of this test. Sa, despite the fact that our horses recovered in TC after exercising in HHC, there were significant differences between their physiological parameters measured during the recovery. This means that the recovery in air-conditionned unit would probably be an insufficient measure to ensure an adequate cooling of the horses and justify consequently the adaptations proposed by the FEI, i.e. the decrease of the distance of the run and the increase of the lime devoted to the hall between phases [less ▲]

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See detailA new HPLC method for the assay of alkaloids in Strychnos nux-vomica and Strychnos ignatii
Gadi Biala, Rose; Tits, Monique ULg; Wauters, Jean-Noël ULg et al

in Fitoterapia (1996), 67(2), 163-165

A reversed-phase high performance liquid chromatographic procedure was developed for the qualitative and quantitative analysis of the alkaloids in S. nux-vomica and S. ignatii.

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See detailLa classification numérique : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1996), (1), 28

The principles of some clustering techniques are described and illustrated by an example. The data consist of chemical contents for 45 types of mineral water.

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See detailA propos de la genèse des orthostates néo-assyriens
Tunca, Önhan ULg

in Tablettes et images aux pays de Sumer et d'Akkad. Mélanges offerts à Monsieur H. Limet (A.P.H.A.O. Mémoires n° 1) (1996)

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See detailCartes de contrôle : les cartes de Shewhart.
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1996), (2), 41

This note describes the SHEWHART control charts for subgroup means, standard deviation, medians, ranges, proportions of defectives, numbers of defectives and numbers of defects. Minitab and SAS outputs ... [more ▼]

This note describes the SHEWHART control charts for subgroup means, standard deviation, medians, ranges, proportions of defectives, numbers of defectives and numbers of defects. Minitab and SAS outputs are given for all these charts. [less ▲]

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See detailTaqi Growth Hormone Gene Polymorphism And Milk Production Traits In Holstein-Friesian Cattle
Falaki, M.; Sneyers, M.; Prandi, A. et al

in Animal Science (1996), 63

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See detailCartes de contrôle : combinaison de résultats, données corrélées ou multivariées
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1996), (3), 1-37

This note first describes moving average, exponentially weighted moving average and cumulative sum control charts. Then, control charts for autocorrelated and for multivariate data are examined. Minitab ... [more ▼]

This note first describes moving average, exponentially weighted moving average and cumulative sum control charts. Then, control charts for autocorrelated and for multivariate data are examined. Minitab outputs are given for these control charts. [less ▲]

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See detailAstroglia-released factor with negative allosteric modulatory properties at the GABA A receptor.
Rigo, Jean-Michel; Belachew, Shibeshih ULg; Coucke, Paul et al

in Biochemical Pharmacology (1996), 52(3), 465-473

We have previously shown, using whole-cell patch-clamp techniques, that astrocytes release a negative allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor) with beta ... [more ▼]

We have previously shown, using whole-cell patch-clamp techniques, that astrocytes release a negative allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor) with beta-carboline-like properties, thus, likely to act at the benzodiazepine site. Here, using patch-clamp and binding techniques, we confirm that the low-molecular-weight fraction of astroglia-conditioned medium (ACM lmf) contains a factor(s) that negatively modulates GABAA-receptor function. This factor, like beta-carbolines, enhances the specific binding of [35S]t-butyl bicyclophosphorothionate (TBPS) to adult rat cortical membranes in the presence of GABA. However, it fails to interact with various ligands of the benzodiazepine (BZD) site of the GABAA receptor ([3H]flunitrazepam, [3H]Ro 15-1788 and [3H]Ro 15-4513). The question of the actual binding site of the astroglia-derived factor on the GABAA receptor, thus, remains open and can be addressed only after the purification of the active molecule(s) of ACM Imf has been completed, and a labeled form of the endogenous ligand becomes available. Taken together, however, the data suggest that type 1 astrocytes are able to modulate the effects of the main inhibitory neurotransmission in the central nervous system. [less ▲]

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See detailLes canaux potassiques ATP-dépendants et la sécrétion d'insuline: effets du BPDZ 62
Ouedraogo, R.; Pirotte, Bernard ULg; Antoine, M. H. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailProbabilities for forbidden transitions in atoms and ions: 1989-1995. A commented bibliography
Biémont, Emile ULg; Zeippen, C. J.

in Physica Scripta (1996), T65

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See detailTomographie a emission de positons dans l'evaluation de l'extension ganglionnaire intrathoracique du cancer bronchique non petites cellules. Etude preliminaire chez 30 patients.
Bury, Thierry ULg; CORHAY, Jean-Louis ULg; Paulus, P et al

in Revue des Maladies Respiratoires (1996), 13(3), 281-286

Current methods for evaluating the mediastinum include chest radiography, computed tomography (CT) or magnetic resonance (MR) imaging and mediastinoscopy. Despite advances in morphologic imaging, some ... [more ▼]

Current methods for evaluating the mediastinum include chest radiography, computed tomography (CT) or magnetic resonance (MR) imaging and mediastinoscopy. Despite advances in morphologic imaging, some lung cancer patients are found to have unresectable disease at surgery. In contrast to CT scan or MR imaging, which depend primarily on anatomic and morphological criteria, positron emission tomography (PET) with 18fluorodeoxyglucose (FDG) depends mainly of the metabolic characteristics of a tissue for the diagnosis of disease. We perform a prospective study to compare FDG-PET and CT of the thorax in the presurgical assessment of the mediastinum in patients with newly diagnosed non-small cell lung cancer. Thirty patients have been included. CT and PET-scans were interpreted separately and results were compared to surgical staging during thoracotomy. In assessing mediastinal involvement, CT scan had a sensitivity of 56% and a specificity of 64%. For diagnosis mediastinal nodal disease, FDG-PET was 87% sensitive and 78% specific. Its positive predictive value was 82%, and the negative value was 83%. In conclusion, our preliminary results show that FDG-PET appears more accurate than CT in staging of mediastinal non-small cell lung cancer. [less ▲]

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See detailActualités thérapeutiques dans la thrombocytémie essentielle
Hermanne, J.-P.; Tassin, F.; Beguin, Yves ULg et al

in Médecine et Hygiène (1996), 54

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of ... [more ▼]

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of thrombocythaemia is controversial. Since th relationship of thrombosis and hemorrhage to platelet counts is not demonstrated, ther is no clear inidcation for using drugs capable of lowering platelet counts in young asymptomatic subjects. However, treatment should be offered to patients with a definite high risk of major or life-threatening hemostatic complications. The present paper reviews the incidence and risk factors for thrombotic complications and the use of medications inhibiting platelet production. [less ▲]

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See detailEvaluation du rôle préventif des oestroprogestatifs et des thérapeutiques non hormonales dans le cadre de l'ostéoporose postménopausique
Reginster, Jean-Yves ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1996), 25(7), 677-83

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of ... [more ▼]

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of osteoporosis is based on efforts to reach a maximal peak bone mass at the end of the growth period and, subsequently, at the time of menopause. No pharmacological intervention is considered at this stage. Biologically, hormone replacement therapy induces a correction of the biochemical changes observed in markers of bone remodeling at the time of the menopause. A systematic screening of asymptomatic postmenopausal women followed by the induction of hormonal replacement therapy in high risk subjects appears to be an interesting cost/benefit strategy in terms of reasonable attribution of health resources. Nasal administration of calcitonin fully prevents the trabecular bone loss observed during the first years of menopause. Notwithstanding, the exact dose of nasal calcitonin able to prevent bone loss remains to be fully elucidated. Bisphosphonates inhibit bone resorption. Tiludronate prevents trabecular postmenopausal bone loss. The use of selectif estrogen receptor modulators is based on a possible differential action of these molecules, at the level of the estrogenic receptors, depending of the tissue considered. Several direct inhibitors of osteoclastic resorption are also under development. Their main target is either to prevent the linkage of osteoclasts to the bone matrix or to prevent the acidification of bone matrix required to induce the resorption process. [less ▲]

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See detailMicrosatellite mapping of a major determinant of White Heifer Disease: the bovine roan locus
Charlier, Carole ULg; Denys, B.; Belanche, J. I. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1996), 7

In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r + (black) and R (white ... [more ▼]

In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r + (black) and R (white). Heterozygous r + R animals have intermingled black and white hairs, yielding the ``blue'' phenotype typical of the breed. Major interest for the roan locus stems from its pleiotropic effect on fertility, owing to the critical role of the R allele in the determinism of White Heifer Disease. We describe the linkage mapping of the roan locus to bovine Chromosome (Chr) 5, in the interval between microsatellite markers BPI and AGLA293, with an associated lodscore of 11.2. Moreover, we map a candidate gene, the Steel locus coding for the mast cell growth factor, to bovine Chr 5. [less ▲]

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See detailLe chaponnage, une technique qui revient à la mode!
Marlier, Didier ULg; Vindevogel, Henri ULg

in Annales de Médecine Vétérinaire (1996), 140

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See detailThe existence of an urban underclass in Belgium
Martiniello, Marco ULg

in New Community (1996), 22(4), 655-669

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See detailAvoided resonance overlapping beyond the energy independent formalism. II. Electronic predissociation
Brems, Vincent; Desouter, Michèle ULg; Liévin, Jacques

in Journal of Chemical Physics (1996), 104

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See detailEffect Of Propylene Glycol Supplementation Around Parturition On Milk Yield, Reproduction Performance And Some Hormonal And Metabolic Characteristics In Dairy Cows
Formigoni, A.; Cornil, Mc.; Prandi, A. et al

in Journal of Dairy Research (1996), 63(1),

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See detailPrimary Systemic Amyloidosis - A report of 2 cases
Dezfoulian, Bita ULg; Arrese Estrada, Jorge ULg; Fernandez, A. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1996), 192

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection ... [more ▼]

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection, inflammation, neoplasms and paraproteinemia was conclusively negative in the other patient. The recognition of cutaneous signs of primary systemic amyloidosis is crucial to insure a rapid management aimed at postponing the fatal issue of the disease. [less ▲]

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See detailEtude des groupements de macrophytes vasculaires aquatiques de la Semois en rapport avec la qualité globale des eaux et du milieu
Thoen, Daniel ULg; Roussel, Laurence; Nicolas, Jacques ULg

in Ecologie (1996), 27(4), 223-232

Les groupements de macrophytes aquatiques de la Semois (ca. 200 km de long) ont été décrits par l'analyse de 218 relevés de végétation réalisés durant l'année 1994. De l'amont vers l'aval, six groupements ... [more ▼]

Les groupements de macrophytes aquatiques de la Semois (ca. 200 km de long) ont été décrits par l'analyse de 218 relevés de végétation réalisés durant l'année 1994. De l'amont vers l'aval, six groupements végétaux ont été caractérisés. Deux zones principales peuvent être distinguées. Dans la zone amont, la végétation potentielle a été détruite ou remplacée par des groupements végétaux, plus résistants à la pollution organique et aux modifications physiques du milieu: groupement à Sparganium emersum et Potamogeton nanans; association à Potamogeton pectinatus. Dans la zone aval, la présence de groupements relevant du Ranunculetum fluitantis est plus conforme à la végétation potentielle et indique de meilleures conditions du milieu. Une analyse canonique des correspondances, sur les principales espèces aquatiques et les paramètres physico-chimiques de l'eau de 40 stations, a permis de regrouper des espèces présentant des affinités écologiques entre elles et de dégager leurs valeurs indicatrices relatives pour certains paramètres abiotiques. [less ▲]

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See detailProbing the Surface Molecular Structure in the UPS Spectra of Octadecanethiol and 1-Cyclohexyl-12-dodecanethiol Self-Assembled on Gold
Duwez, Anne-Sophie ULg; Riga, Joseph; Han, Bo-Ying et al

in Journal of Electron Spectroscopy & Related Phenomena (1996), 81

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See detail9-Methoxygeissoschizol, an alkaloid from bark of strychnos guianensis
Mavar-Manga, Hélène; Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg et al

in Phytochemistry (1996), 43(5), 1125-1127

The isolation and structure determination of 9-methoxygeissoschizol from the stem bark of Strychnos guianensis is described. Elucidation of its structure is mainly based on NMR studies.

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See detailEtat-providence et efficacité économique
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in Revue Française d'Economie (1996), XI, 2(Printemps), 29-44

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See detailIs IL-6 capable to modify chondrocyte metabolism ?
Henrotin, Yves ULg; Labasse, A; Jaspar, JM et al

in Clinical Rheumatology (1996), 15

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See detailLe Calendrier et son Histoire
Biémont, Emile ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1996), 6e série(VII), 15-71

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See detailLa myxomatose amyxomateuse: isolement de trois souches en Belgique
Marlier, Didier ULg; Vindevogel, Henri ULg

in Annales de Médecine Vétérinaire (1996), 140

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See detailLe frêne, un bois noble et précieux
Claessens, Hugues ULg

in Forêt Wallonne (1996), 28

Avec le bouleau, l'aulne glutineux, les tilleuls, les érables, le merisier et d'autres feuillus relativement marginaux dans le marché du bois, le frêne fait partie des espèces secondaires de la forêt ... [more ▼]

Avec le bouleau, l'aulne glutineux, les tilleuls, les érables, le merisier et d'autres feuillus relativement marginaux dans le marché du bois, le frêne fait partie des espèces secondaires de la forêt wallonne, qui, ensemble ne représentent que 7% du volume sur pied, alors qu'à eux seuls, le hêtre, les chênes et l'épicéa en totalisent 85% (données IFW). Certaines, comme le frêne, sont qualifiées de "nobles" ou encore de "précieuses" en raison de leur valeur marchande (frêne, érable et merisier). Une des causes de ce phénomène est le choix délibéré des propriétaires forestiers, qui, pour des raisons que nous connaissons, à la fois historiques et liées aux marchés du bois passé et actuel, ont préféré le hêtre, le chêne et l'épicéa, souvent sous forme de monoculture, réduisant ainsi l'espace qui revenait naturellement aux espèces secondaires, naturellement disséminées dans nos forêts. [less ▲]

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See detailDéveloppement d'un modèle de type arbre appliqué à la croissance des peuplements feuillus irréguliers du sud de la Belgique
Lejeune, Philippe ULg

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (1996), 26(10), 1838-1848

A model predicting circumference growth of individual trees has been developed for mixed irregular stands dominated by Fagus silvatica L. in southeastern Belgium. This model integrates simultaneously tree ... [more ▼]

A model predicting circumference growth of individual trees has been developed for mixed irregular stands dominated by Fagus silvatica L. in southeastern Belgium. This model integrates simultaneously tree, stand, and growing site characteristics without considering distances between individual trees. It has a determination coefficent of 40.1 % and a residual standard deviation of 0.45cm/year. Forest mensuration variables considered in the model are circumference, tree social position represented by the total basal area of trees greater than the subject tree, stand basal area, and some index of stand structure corresponding to the ratio of the variance over the mean circumference. The site component is essentially expressed by the length of the growing period. The low accuracy obtained for individual tree growth is relative because the results are used mainly after individual trees have been distributed into size classes. We have been able to show that the introduction of crown description in the model can increase its accuracy. But this modification requires a submodel describing crown changes over time. [less ▲]

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See detailCardiovascular involvement during HIV infection.
Valdes, E. F.; Fernandez, R. E.; Villanueva, H. R. et al

in European Heart Journal (1996), 17(10), 1605

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See detailLes constructions analogiques du futur III
Winand, Jean ULg

in Revue d'Egyptologie (1996), 47

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See detailEndometrial laser interstitial hyperthermy: a potential modality for endometrial ablation.
Donnez, Jacques; Polet, Roland; Mathieu, Pierre-Emmanuel et al

in Obstetrics & Gynecology (1996), 87(3), 459-64

This study was undertaken to evaluate the efficacy and safety of an intrauterine device designed for endometrial ablation by Nd-YAG laser interstitial hyperthermy. Eight hysterectomy specimens were ... [more ▼]

This study was undertaken to evaluate the efficacy and safety of an intrauterine device designed for endometrial ablation by Nd-YAG laser interstitial hyperthermy. Eight hysterectomy specimens were treated in vitro with an output power of 30 W for 5 minutes; tissue temperatures, recorded by thermocouples, were plotted to draw time-temperature and time-distance curves. As a preliminary series, ten patients were treated, with the first five subjected to local temperature monitoring; all ten were followed-up for 6-17 months. Immediate and delayed (6 weeks) histologic data were obtained. The intramural temperature at 6 mm from the fibers ranged from 55-60C). In vivo, the cooling effect of the arterial blood flow lowered the serosal temperatures under 41C. The histologic data and the hysterographic pictures suggest that endometrial ablation was effective. This new device does not require distending medium, hysteroscopic control, or high-powered Nd-YAG laser machines. Preliminary long-term results suggest that the device could be used for endometrial ablation. [less ▲]

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See detailParadoxical Sleep Deprivation Increases the Content of Glutamate and Glutamine in Rat Cerebral Cortex
Bettendorff, Lucien ULg; Sallanon-Moulin, M.; Touret, Monique et al

in Sleep (1996), 19(1), 65-71

We investigated the influence of the sleep/waking cycle, the effects of paradoxical sleep deprivation (PSD) and of the vigilance-promoting drug modafinil on the amino acid contents of rat brain cortex. No ... [more ▼]

We investigated the influence of the sleep/waking cycle, the effects of paradoxical sleep deprivation (PSD) and of the vigilance-promoting drug modafinil on the amino acid contents of rat brain cortex. No significant nycthemeral variations in amino acid levels could be detected. PSD (12-24 hours), using the water tank method, significantly increased the levels of glutamate and glutamine. The increase was still observed after the sleep rebound period. gamma-Aminobutyric acid (GABA) levels did not change significantly during the instrumental sleep deprivation but increased during the rebound period. Control experiments indicate that the increase in glutamate and glutamine levels is due to PSD rather than to the stress associated with the experimental procedure. The increase in glutamate content cannot arise only from transamination reactions, because the levels of other amino acids (such as aspartate) did not decrease. Modafinil treatment did not significantly modify the brain cortex content of any of the amino acids tested. [less ▲]

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See detailT92-0045: Interlaboratory quality control on Tpot measurements
Coucke, Philippe ULg; Beer, K.; Bernier, J. et al

in International Journal of Radiation, Oncology, Biology, Physics (1996), 36(1(supp1)), 384

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See detailDensité osseuse fémorale et carence vitaminique D dans une population de femmes âgées
DEROISY; Pirenne, H; FREDERICK, Isabelle ULg et al

in Archives of Public Health (1996), 53(S1), 37

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See detailIn situ demonstration of germinal cell apoptosis during diethylstilbestrol-induced testis regression in adult male syrian hamsters
Nonclercq, D.; Reverse, D.; Toubeau, G. et al

in Biology of Reproduction (1996), 55(6), 1368-1376

Testis regression was induced in male Syrian hamsters by chronic exposure to diethylstilbestrol (DES), an estradiol-1713 agonist. Experimental groups (n = 4-5) were killed at increasing time intervals ... [more ▼]

Testis regression was induced in male Syrian hamsters by chronic exposure to diethylstilbestrol (DES), an estradiol-1713 agonist. Experimental groups (n = 4-5) were killed at increasing time intervals over a period of 6 mo after initiation of treatment. Apoptosis in testes was demonstrated by in situ analysis of DNA fragmentation. Cell proliferation was monitored by immunostaining nuclei of S-phase cells after pulse labeling with 5-bromo-2'-deoxyuridine. Levels of FSH and testosterone, measured by RIA, fell rapidly in DES-treated hamsters. In parallel, testis weight and seminiferous tubule area underwent an 80% decrease during the first 2 wk of DES administration. The composition of seminiferous epithelium was also drastically affected by DES, since it became progressively confined to Sertoli cells, spermatogonia, and spermatocytes. Testis regression was associated with an important increase of apoptosis, which started 3 days after the beginning of DES administration. Apoptosis was still 10- to 50-fold higher than in control testes by the end of treatment; it affected primarily spermatocytes and, to a much lesser extent, spermatogonia. Cell proliferation was not inhibited by chronic DES administration. In conclusion, these data indicate that apoptosis can by itself account for estrogen-induced testis regression. [less ▲]

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See detailMuscle protein metabolism in relation to growth rate in double muscled Belgian Blue bulls: an integrated approach
Van Eenaeme, Christian ULg; Hornick, Jean-Luc ULg; Baldwin, Paule et al

in Mededelingen van de Faculteit van Landbouwwetenschappen, Rijksuniversiteit, Gent (1996), 61/4a

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See detailVaricella-zoster virus : a cause of waxing and waning vasculitis. The New England Journal of Medicine case 5-1995 revisited
Gilden, D. H.; Kleinschmidt-DeMasters, B. K.; Wellish, M. et al

in Neurology (1996), 47(6), 1441-1446

A 73-year-old man developed an ill-defined fatal vasculitis involving the central nervous system. The case report was published as a clinicopathologic exercise in February 1995 in The New England Journal ... [more ▼]

A 73-year-old man developed an ill-defined fatal vasculitis involving the central nervous system. The case report was published as a clinicopathologic exercise in February 1995 in The New England Journal of Medicine.(1) We restudied the pathologic material and found both varicella tester virus (VZV) DNA and VZV-specific antigen, but not herpes simplex virus (HSV) or cytomegalovirus (CMV) DNA or HSV- or CMV-specific antigen, in three of the five cerebral arteries examined. The inflammatory response, disruption of the internal elastic lamina, and detection of viral antigen were patchy from one artery to another, as well as within a given artery. A search for VZV should be conducted in cases of vasculitis when both the central and peripheral nervous systems are involved, when focal narrowing is present in large arteries, when brain imaging reveals infarction in gray and white matter, both deep and superficial, and when white matter is disproportionally involved. Zosteriform rash is not required for diagnosis. [less ▲]

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See detailIn vitro activity of amoxycillin/clavulanate and ticarcillin/clavulanate compared with that of other antibiotics against anaerobic bacteria: comparison with the results of the 1987 survey
Pierard, denis; De Meyer A; Rosseel, P. et al

in Acta Clinica Belgica (1996), 51(2), 70-9

The activity of amoxycillin/clavulanate (Augmentin) and ticarcillin/ clavulanate (Timentin) was tested against 351 strict anaerobic clinical isolates collected from September 1993 to April 1994 in eight ... [more ▼]

The activity of amoxycillin/clavulanate (Augmentin) and ticarcillin/ clavulanate (Timentin) was tested against 351 strict anaerobic clinical isolates collected from September 1993 to April 1994 in eight Belgian university hospitals and compared with that of 8 other antibiotics using the NCCLS reference agar dilution procedure. Production of beta-lactamase was detected by the nitrocefin test in 48% of the isolates. At NCCLS-recommended breakpoints, more than 90% of isolates were susceptible to amoxycillin/clavulanate, ticarcillin/clavulanate, piperacillin/tazobactam, imipenem, chloramphenicol and metronidazole but only 77%, 72% and 48% to cefoxitin, clindamycin and penicillin, respectively. In comparison with the results of a similar survey conducted in 1987 no major changes in susceptibility were observed except for the susceptibility to clindamycin that declined from 83% to 72% overall, and from 83% to 66% in the B. fragilis group. Furthermore one isolate of Clostridium clostridioforme was found produce beta-lactamase and few B. fragilis group isolates showed reduced susceptibility to metronidazole. [less ▲]

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See detailCuba in tijden van periodo especial
Vanden Berghe, Kristine ULg

in Romaneske (1996), 21(1), 40-44

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See detailThe effect of aging on facial prototype formation
Van der Linden, Martial ULg; Bruyer, R.; Schils, J. P.

in Current Psychology of Cognition [=CPC] = Cahiers de Psychologie Cognitive [=CPC] (1996), 15(4), 435-445

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See detailLes maladies virales chez le lapin européen (Oryctolagus cuniculus)
Marlier, Didier ULg; Vindevogel, Henri ULg

in Annales de Médecine Vétérinaire (1996), 140

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See detailEthnic Mobilisation, Multiculturalism and the Political Process in two Belgian Cities : Antwerp and Liège
Martiniello, Marco ULg; Blommaert, Jan

in Innovation in Social Sciences Research (1996), 9(1), 51-74

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See detailBrain Levels of Thiamine and Its Phosphate Esters in Friedreich's Ataxia and Spinocerebellar Ataxia Type 1
Bettendorff, Lucien ULg; Mastrogiacomo, Frank; LaMarche, J. et al

in Movement Disorders : Official Journal of the Movement Disorder Society (1996), 11(4), 437-439

Decreased blood and cerebrospinal fluid levels of thiamine have been reported in patients with spinocerebellar ataxia disorders. To determine whether a thiamine deficiency is present in the brain, we ... [more ▼]

Decreased blood and cerebrospinal fluid levels of thiamine have been reported in patients with spinocerebellar ataxia disorders. To determine whether a thiamine deficiency is present in the brain, we measured levels of thiamine and its phosphate esters thiamine monophosphate (TMP) and thiamine diphosphate (TDP), in postmortem cerebellar and cerebral cortices of patients with Friedreich's ataxia (FA) and spinocerebellar ataxia type 1 (SCA1). Brain levels of free (nonphosphorylated) thiamine, TMP, TDP, and total thiamine in FA and SCA1 were, on average, not significantly different from control values. However, a nonsignificant trend was observed for slightly reduced levels of TDP and total thiamine in cerebellar cortex of the SCA1 patients, a finding that might be related to the severe neuronal damage in this brain area. We conclude that in FA, brain thiamine concentrations are normal, whereas in SCA1 the levels are, at most, only slightly reduced. [less ▲]

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See detailGuidelines for authors of medical scientific manuscripts.
Detry, Olivier ULg; Van Damme, Hendrik ULg; Van de Stadt, J.

in Acta Chirurgica Belgica (1996), 96(4), 140-3

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See detailTwo-Phase Finite Element Comparative Study of a Side Structure of a Middle Size Tanker
Sumi, Y.; Cervetto, D.; Das, P.K. et al

in Marine Structures (1996)

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See detailDescription des plantules de quatre Caesalpiniacées africaines
Léonard, J.; Doucet, Jean-Louis ULg

in Bulletin du Jardin Botanique National de Belgique = Bulletin van de Nationale Plantentuin van België (1996), 66

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See detailRecherches sur le Paléolithique supérieur de la Moldavie
Otte, Marcel ULg; López Bayón, Ignacio; Noiret, Pierre ULg et al

in Anthropologica et Praehistorica : Bulletin de la Société Royale Belge d'Anthropologie et de Préhistoire (1996), 107

The Moldavian sequence is an illustration of all the phases of the Upper Palaeolithic. It starts with archaic industries (with bifacial foliate points), then is going on with local Aurignacian industries ... [more ▼]

The Moldavian sequence is an illustration of all the phases of the Upper Palaeolithic. It starts with archaic industries (with bifacial foliate points), then is going on with local Aurignacian industries, and finally show a very intensive development of Gravettian industries. Its geographical position gives it a key-position for the study of the relationships between the hills of Central Europe and the wide eastern plains. [less ▲]

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See detailMorphometric, immunohistological and three-dimensional evaluation of the endometrium of menopausal women treated by oestrogen and Crinone, a new slow-release vaginal progesterone.
Casanas-Roux, Françoise; NISOLLE, Michelle ULg; Marbaix, Etienne et al

in Human Reproduction (1996), 11(2), 357-63

Recently advanced computerized technology was applied to the investigation of morphometric, immunohistological and three-dimensional changes of the endometrial mucosa in order to evaluate quantitatively ... [more ▼]

Recently advanced computerized technology was applied to the investigation of morphometric, immunohistological and three-dimensional changes of the endometrial mucosa in order to evaluate quantitatively the effects of three doses of a new slow-release vaginal progesterone on the endometrium in post-menopausal women. A total of 20 menopausal women, deprived of ovarian function, were given oestrogen for 12 days and a combined therapy of oestrogen (administered orally) and progesterone for another 12 day period. Progesterone was administered vaginally through a new gel (Crinone) utilizing a bioadhesive, biocompatible polymer as a base to achieve a sustained release effect. An endometrial biopsy was taken before treatment, after oestrogen-only treatment and after the oestro-progestogen therapy. Before treatment, all the patients exhibited an atrophic endometrium. After oestrogen-only treatment, typical proliferative changes occurred: an increase in the endometrium thickness, an increase in the mitotic index, numerous cylinder-like glands and no coiled glands, and high concentrations of oestrogen receptors (ER) and progesterone receptors (PR). After the oestro-progestogen therapy, whatever the dose of progesterone given, a secretory transformation of the endometrial mucosa occurred, mitotic activity decreased significantly, more ramified and coiled glands were observed, and a decrease in PR content was noted in epithelial and stromal nuclei, and a decrease in PR content was also observed in epithelial nuclei but not in stromal nuclei. Accurate new techniques of image analysis have shown that crinone therapy could eliminate the proliferative effects of oestrogen treatment in post-menopausal women, despite doses as low as 45 mg of progesterone administered vaginally every other day. The results suggest that the sustained release effects of Crinone are clinically relevant. [less ▲]

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See detailL’ostéomalacie : étiologie, clinique, physiopathologie et thérapeutique
Reginster, Jean-Yves ULg

in Le Monde Médical de la Femme (1996), 330(23), 18-21

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See detailConditional heteroskedasticity adjusted market model and an event study
Corhay, Albert ULg; Tourani-Rad, Alireza

in Quarterly Review of Economics and Finance (1996), 36(4), 529-538

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See detailLocal orders in II-VI liquid compounds
Gaspard, Jean-Pierre ULg; Raty, Jean-Yves ULg; Ceolin, R. et al

in Journal of Non-Crystalline Solids (1996), 205-207

The structure of liquid CdTe, HgTe and ZnTe is studied by neutron scattering. Upon melting, drastically different behaviors are found: CdTe and ZnTe keep their fourfold coordination in the melt and remain ... [more ▼]

The structure of liquid CdTe, HgTe and ZnTe is studied by neutron scattering. Upon melting, drastically different behaviors are found: CdTe and ZnTe keep their fourfold coordination in the melt and remain semiconductors, whereas HgTe becomes sixfold coordinated and metallic. This dissimilarity is discussed in terms of the electronegativity difference and of the repulsive potential hardness. Entropic aspects are also discussed [less ▲]

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See detailRheumatic and musculoskeletal diseases and impaired quality of life. A challenge for rheumatologists
Morales-Torres, J; Reginster, Jean-Yves ULg; Hochberg, MC

in Journal of Rheumatology (1996), 23

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See detailInfluence of Van Hove singularity on the electronic specific heat of high-Tc superconductors
Dorbolo, Stéphane ULg; Houssa, Michel; Ausloos, Marcel ULg

in Physica C: Superconductivity (1996)

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See detailIdentification of antigens recognized in the developing mouse brain by the RC2 antibody, a marker of radial glia
Leprince, Pierre ULg; Chanas-Sacre, G.; Wattiez, R. et al

in International Journal of Developmental Neuroscience (1996), 14(Sup. 1), 84

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See detailCost effectiveness of treatment in osteoporosis
Reginster, Jean-Yves ULg

in Journal of Rheumatology (1996), 23(7), 1312-1313

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See detailNouveaux bisphosphonates dans l’ostéoporose : craintes et espoirs
Reginster, Jean-Yves ULg

in Revue du Rhumatisme (1996), 63(7-8), 545-548

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See detailCalculations of inner shell transitions in Ca+
Hansen, J E; Quinet, Pascal ULg

in Journal of Electron Spectroscopy & Related Phenomena (1996), 79

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See detailComparison of food conversion by the Pirapatinga Piaractus brachypomus under different times of feeding
Baras, E.; Mélard, Charles ULg; Grignard, J. C. et al

in Progressive Fish-Culturist (1996), 58

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See detailEffect of total treatment time on event-free survival in carcinoma of the cervix
Delaloye, J-F; COUCKE, Philippe ULg; Pampallona, S et al

in Gynecologic Oncology (1996), 60

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See detailExpression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons
Mahalingam, Ravy; Wellish, Mary; Cohrs, Randall et al

in Proceedings of the National Academy of Sciences of the United States of America (1996), 93(5), 2122-2124

The ganglionic cell type in which varicellazoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein, VZV open reading ... [more ▼]

The ganglionic cell type in which varicellazoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein, VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system. [less ▲]

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See detailEffect Of Oral And Parenteral N Nutrition Vs N-Free Nutrition On The Endogenous Amino Acid Flow At The Ileum Of The Pig
Leterme, Pascal; Monmart, Thierry; Thewis, André ULg et al

in Journal of the Science of Food and Agriculture (1996), 71(2), 265-271

Two methods were tested for suppressing the depressive effect of N-free diets on the digestive secretions in pigs: the blood perfusion of amino acids (AA) or the peptide alimentation method. In the latter ... [more ▼]

Two methods were tested for suppressing the depressive effect of N-free diets on the digestive secretions in pigs: the blood perfusion of amino acids (AA) or the peptide alimentation method. In the latter, enzymically hydrolysed casein (EHC), composed of oligopeptides and free AA, was used as the source of nitrogen. The unabsorbed dietary N molecules were discarded from the ileal digesta by ultrafiltration or gel filtration, assuming that the endogenous fraction did not contain significant amounts of small molecules. The AA supply by blood perfusion had no effect on the ileal endogenous AA losses (8.0 g AA kg-' DM intake) in growing pigs (k 50 kg), compared with the N-free diet alone (8.3 g), whereas the EHC supplementation significantly increased them (18.0 8). The increase was due to both endogenous and dietary N. The presence of unabsorbed dietary AA in the ileal digesta was confirmed by the AA profile of the soluble molecules with a very low molecular mass (< 3 kDa), which was close to that of EHC. Both ultrafiltration (cut-offs of 3 or 10 kDa) and gel filtration methods, utilised to discard the remaining dietary molecules, also eliminated a significant proportion of endogenous AA. [less ▲]

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See detailSelection of hammerhead ribozymes for optimum cleavage of interleukin 6 mRNA.
Hendrix, Chris; Anne, J; Joris, Bernard ULg et al

in Biochemical Journal (1996), 314 ( Pt 2)

Four GUC triplets in the coding region of the MRNA of interleukin 6 (IL-6) were examined for their suitabilty to serve as a target for hammerhead ribozome-mediated cleavage. This selection procedure was ... [more ▼]

Four GUC triplets in the coding region of the MRNA of interleukin 6 (IL-6) were examined for their suitabilty to serve as a target for hammerhead ribozome-mediated cleavage. This selection procedure was performed with the intention to downregulate IL-6 production as a potential treatment of those diseases in which IL-6 overexpression is involved. Hammerhead ribozymes and their respective short synthetic substrates (19-mers) were synthesized for these four GUC triplets. Notwithstanding the identical catalytic core sequences, the difference in base composition of the helices involved in substrate binding caused substantial variation in cleavage activity. The cleavage reactions on the 1035 nucleotide IL-6 mRNA transcript revealed that two ribozymes were able to cleave this substrate, showing a decrease in catalytic efficiency to 1/30 and 1/300 of the short substrate. This study indicates that the GUC triplet located at nucleotide 510 of the mRNA of IL-6 is the best site for hammerhead ribozyme-mediated cleavage. We suggest that in future targeting of chemically modified hammerhead ribosomes for cleavage of IL-6 RNA should be directed at this location. [less ▲]

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See detailAnalysis of synchronization constraints and associated errors in collective work environments
Nyssen, Anne-Sophie ULg; Javaux, D.

in Ergonomics (1996), 39(10), 1249-1264

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See detailCloning and Sequencing of the Dnak Locus in Streptomyces Coelicolor A3(2)
Brans, Alain ULg; Loriaux, Axelle; Joris, Bernard ULg et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1996), 6(3), 179-84

The dnaK operon of Streptomyces coelicolor A3(2) was cloned by the DNA-probing method using synthetic oligonucleotides designed on the basis of two of the most conserved regions in 30 different DnaK ... [more ▼]

The dnaK operon of Streptomyces coelicolor A3(2) was cloned by the DNA-probing method using synthetic oligonucleotides designed on the basis of two of the most conserved regions in 30 different DnaK proteins (HSP70). The isolated insert-a BamHI 5.6-kb fragment-was sequenced and shown to contain three open-reading frames organized in an operon and coding for proteins analogous to DnaK, GrpE and DnaJ, successively. [less ▲]

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See detailPrediction of signal peptide functional properties: a study of the orientation and angle of insertion of yeast invertase mutants and human apolipoprotein B signal peptide variants.
Talmud, P.; Lins, Laurence ULg; Brasseur, Robert ULg

in Protein Engineering (1996), 9(4), 317-21

A number of studies have introduced mutations into the yeast invertase signal peptide, using it as a model system to elucidate features for targeting, translocation and intracellular transport. Using ... [more ▼]

A number of studies have introduced mutations into the yeast invertase signal peptide, using it as a model system to elucidate features for targeting, translocation and intracellular transport. Using molecular modelling of the invertase signal peptide we have analysed the hydrophobicity potential and the change in dielectric constant of the energy transfer, when the molecule moves from a hydrophobic to a hydrophilic phase at the simulated hydrophobic-hydrophilic interface. This modelling has been carried out on wild type and mutant invertase signal peptides of altered function, previously reported in the literature. While the predicted angle of insertion correlates with the measured extent of invertase secretion, with an optimum angle of 45 degrees, mutations that change the angle of orientation reduce the extent of invertase secretion. We have applied these same molecular modelling principles to the naturally occurring variants of the human apolipo-protein B (apoB) signal peptide, that confer a secretion defective phenotype when fused to yeast invertase and expressed in yeast. Our modelling thus identifies a strong correlation between the predicted angle of insertion of the signal peptide into the membrane and its ability to direct secretion. [less ▲]

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See detailCardiovascular risk factors in children from the Belgian province of Luxembourg. The Belgian Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Beckers, L. et al

in American Journal of Epidemiology (1996), 144(9), 867-80

The Province of Luxembourg is an area in Belgium with a high prevalence of risk factors for cardiovascular disease and non-insulin-dependent diabetes mellitus among adults. In the present study, children ... [more ▼]

The Province of Luxembourg is an area in Belgium with a high prevalence of risk factors for cardiovascular disease and non-insulin-dependent diabetes mellitus among adults. In the present study, children in the age groups 6-8, 8-10, and 10-12 years were selected at random from school classes (n = 1,028), with a participation rate of 70.3%. Anthropometric factors, blood pressure, and fasting blood glucose, plasma cholesterol, triglyceride, and insulin levels were measured in 1992. All anthropometric and metabolic variables increased with age, except for waist: hip circumference ratio in boys and cholesterol in girls. In the oldest group, girls who had passed menarche were taller and heavier and had greater skinfold, body mass index, insulin, and systolic blood pressure values but lower total cholesterol levels and waist: hip ratios than girls who had not passed menarche. Boys had lower skinfolds and higher waist: hip ratios than girls in all age groups, and were significantly shorter and lighter in the oldest age group. There was no difference in body mass index between the two sexes. Girls had higher triglyceride and insulin levels in the 10- to 12-year age group, lower blood glucose values in the 8-10 and 10-12 age groups, and lower diastolic blood pressures in the 8-10 age group. Obesity, blood glucose, triglycerides, insulin, and blood pressure were highly interrelated. Cholesterol, triglycerides, insulin, and blood pressure values were all among the highest of values previously reported in other studies. The deciles of body mass index above 50 appeared to be particularly elevated, suggesting that obesity, when present, was pronounced in this population of children. These findings suggest an accumulation of genetic susceptibility to cardiovascular disease and non-insulin-dependent diabetes mellitus in this stable, ethnically homogeneous, and rather isolated part of continental Europe. [less ▲]

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See detailDu gang au groupe social: une analyse socio-préventive
Comeron, Manuel ULg

in Cahiers de la Sécurité (1996)

Au delà d'une enceinte ludique, le stade de football est le théatre d'un supporterisme démonstratif: agressivité des ultra ou hooligan, exaspération partisane, foule. Le supporter est l'objet d'étude de ... [more ▼]

Au delà d'une enceinte ludique, le stade de football est le théatre d'un supporterisme démonstratif: agressivité des ultra ou hooligan, exaspération partisane, foule. Le supporter est l'objet d'étude de la recherche qui évalue aussi les politiques publiques de prévention. [less ▲]

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