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See detailPrenatal diagnosis of pyruvate carboxylase defiency by direct measurement of catalytic activity on chorionic villi samples
Van Coster; Janssens, S.; Misson, Jean-Paul ULg et al

in Prenatal Diagnosis (1998), 18

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See detailCrystal structures of the psychrophilic a-amylase from Alteromonas haloplanctis in its native form and complexed with an inhibitor
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (1998), 7(6), 564-572

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See detailDetermination of radiative lifetimes of neutral sulphur by time-resolved three-photon VUV laser spectroscopy
Li, Z. S.; Persson, A.; Svanberg, S. et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1998), 2

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See detailArbres fruitiers et virus: le diagnostic moleculaire.
Kummert, J.; Lepoivre, Philippe ULg

in Agricontact (1998), (302),

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See detailDirect Quantitative Analysis of Linamarin in Cassava by High-Performance Thin Layer Chromatography
Bodart, Patricia; Penelle, Jacques; Angenot, Luc ULg et al

in Journal of Planar Chromatography- Modern TLC (1998), 11(January/February), 38-42

A simple, rapid and accurate HPTLC quantitative procedure is presented for the direct determination of linamarin. A cassava sample was extracted with boiling 80% v/v methanol and the extract and linamarin ... [more ▼]

A simple, rapid and accurate HPTLC quantitative procedure is presented for the direct determination of linamarin. A cassava sample was extracted with boiling 80% v/v methanol and the extract and linamarin were applied to silicagel HPTLC plates prewashed by development with methanol.The plates were first developed to a distance of 30mm with ethyl acetate-acetone-water, 40+50+10 (v/v), then to a distance of 85 mm with ethyl acetate-formic acid-water, 60+10+10 (v/v). the spots were visualized by dipping the plate into a solution af aniline (2%), and phosphoric acid 15% in acetone, then heating at 105°C for 60 min. Densitometric quantification was effected at lambda= 525 nm by transmission scanning. The method was validated for accuracy, intraday, and interday reproducibility of peak area, linearity, and detection limit. [less ▲]

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See detailParcours lapidaire à travers le Musée en Plein Air du Sart-Tilman
Duchesne, Jean-Patrick ULg

in Bulletin de la commission royale des Monuments, Sites et Fouilles (1998), 16.1

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See detailIs automatic disinfection between each endoscopy mandatory? Jury opinion
Delwaide, Jean ULg; Pelckmans, P.; Defrance, P. et al

in Acta Gastro-Enterologica Belgica (1998), 61(4), 429-430

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See detailThe origin of the alpha-domain intermediate in the folding of hen lysozyme
Matagne, André ULg; Chung, E. W.; Ball, L. J. et al

in Journal of Molecular Biology (1998), 277(5), 997-1005

Stopped-flow fluorescence and circular dichroism spectroscopy have been used in conjunction with quenched-flow hydrogen exchange labelling, monitored by electrospray ionization mass spectrometry, to ... [more ▼]

Stopped-flow fluorescence and circular dichroism spectroscopy have been used in conjunction with quenched-flow hydrogen exchange labelling, monitored by electrospray ionization mass spectrometry, to compare the refolding kinetics of hen egg-white lysozyme at 20 degrees C and 50 degrees C. At 50 degrees C there is clear evidence for distinct fast and slow refolding populations, as observed at 20 degrees C, although folding occurs significantly more rapidly. The folding process is, however, substantially more cooperative at the higher temperature. In particular, the transient intermediate on the major refolding pathway at 20 degrees C, having persistent native-like structure in the alpha-helical domain of the protein, is not detected by hydrogen exchange labelling at 50 degrees C. Ln addition, the characteristic maximum in negative ellipticity and the minimum in fluorescence intensity observed in far UV CD and intrinsic fluorescence experiments at 20 degrees C, respectively, are not seen at 50 degrees C. Addition of 2 M NaCl to the refolding buffer at 50 degrees C, however, regenerates both the hydrogen exchange and optical properties associated with the alpha-domain intermediate but has no significant effect on the overall refolding kinetics. Together with previous findings, these results indicate that non-native interactions within the alpha-domain intermediate are directly responsible for the unusual optical properties observed during refolding, and that this intermediate accumulates as a consequence of its intrinsic stability in a folding process where the formation of stable structure in the beta-domain constitutes the rate-limiting step for the majority of molecules. (C) 1998 Academic Press Limited. [less ▲]

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See detailProtein composition and agglomeration tendency of gluten isolated from European wheats (Triticum aestivum L.) in a batter system
Roels, S. P.; Sindic, Marianne ULg; Deroanne, Claude et al

in Journal of Agricultural and Food Chemistry (1998), 46(4), 1344-1349

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons ... [more ▼]

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons) resulted in, on average, gluten yields of 9.6% (4.7-13.2% range). Gluten protein recoveries averaged 63.0% (34.5-85.7% range). Gluten yields and gluten protein recoveries were linearly related and increased when mixing times and baking absorptions required for optimal dough development of the parent flours increased, indicating that there is a relationship between the agglomeration properties of gluten proteins in a batter system and the optimal technological conditions necessary for processing the flours in breadmaking. The Osborne protein fractions in the gluten fractions were determined. The 0.05 M acetic acid soluble (glutenin) fraction was quantitatively the most important fraction (40-46% of gluten Kjeldahl nitrogen) while comparable levels of 70% ethanol soluble (gliadins) and 0.05 M acetic acid insoluble (residue protein) were found (17.9-22.3% of gluten Kjeldahl nitrogen and 22.0-29.0% of gluten Kjeldahl nitrogen for gliadins and residue protein, respectively). With decreasing pore size of the sieves, the level of glutenin in the gluten decreased while the level of gliadins increased. This indicates that, in gluten with good agglomeration properties, the level of glutenins is high and that the agglomeration properties of such proteins (i.e. their tendency to aggregate) strongly determines the agglomeration behavior of the gluten as a whole. [less ▲]

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See detailLa trichonémose larvaire chez le cheval : examens complémentaires et nouvelles approches thérapeutiques et prophylactiques
Losson, Bertrand ULg; Mignon, Bernard ULg

in Monde Vétérinaire (Le) : European Veterinary Magazine (1998), 45

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See detailThe Prose Poem and the Critics
Delville, Michel ULg

in The Prose Poem: an International Journal (1998)

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See detailLow-productive alpha-herpesviridae infection in chronic lichenoid dermatoses
Nikkels, Arjen ULg; Sadzot-Delvaux, Catherine ULg; Rentier, Bernard ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1998), 196(4), 442-446

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative ... [more ▼]

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative pathomechanisms suggests an altered virus-host cell relationship. OBJECTIVE/METHODS: This report investigates by histology, immunohistochemistry and in situ hybridization the histological and virological features of 6 protracted, indolent HSV infections and 2 prolonged zoster infections. RESULTS: Histopathology revealed a lichenoid dermatitis in all patients. Specific HSV-1, HSV-2 and VZV in situ hybridization proved the viral origin of the cutaneous lesions. Immunohistochemical assessment demonstrated the intracellular presence of the HSV glycoproteins gB, gC and gD in epidermal keratinocytes which did not exhibit cytolysis. Similar findings were obtained for the VZV gE and gB. CONCLUSION: These results suggest that in some instances HSV and VZV infections may present a protracted disease course associated with a lichenoid inflammatory pattern and a non-cytolytic virus-host cell relationship. [less ▲]

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See detailConservative Mutations In The Immunosuppressive Region Of The Bovine Leukemia Virus Transmembrane Protein Affect Fusion But Not Infectivity In Vivo
GATOT, Jean-Stéphane ULg; Callebaut, I.; Mornon, Jp. et al

in Journal of Biological Chemistry (1998), 273(21),

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See detailChanges of chlorophyll(ide) fluorescence yield induced by a short light pulse as a probe to monitor the early steps of etioplast phototransformation in dark-grown leaves
Eullaffroy, P.; Popovic, R.; Franck, Fabrice ULg

in Photochemistry & Photobiology (1998), 67(6), 676-682

The fluorescence yield of chlorophyll(ide) (ChI[ide]) excited by weak modulated light was recorded at room temperature during a 2 h period after a short actinic light pulse that transformed all ... [more ▼]

The fluorescence yield of chlorophyll(ide) (ChI[ide]) excited by weak modulated light was recorded at room temperature during a 2 h period after a short actinic light pulse that transformed all photoactive protochlorophyllide in dark-grown barley leaves. A typical pattern of fluorescence yield variations was found whatever the age of the leaf but with age-dependent changes in rates. Its successive phases were related to the Chl(ide) spectral shifts observed in low-temperature emission spectra. The fluorescence yield started at a high level and strongly declined during the formation of Chlide(695) from Chlide(688) within a few seconds. It increased to a transient maximum during the Shibata shift (15-25 min) that resulted in ChI(ide)(682). A final, slow decrease to a steady state occurred during the final red shift to ChI(685). Pretreatments with delta-aminolevulinic acid, chloramphenicol or 1,10-phenanthroline resulted in correlated modifications of Chl(ide) fluorescence yield transients and shifts of the low-temperature Chl(ide) emission band. The complex response of the final decrease phase of the fluorescence yield to these compounds suggests that it results both from the assembly of photosynthetic Chi proteins and from the reorganization of the etioplast membrane system. From these results it is concluded that continuous recordings of CN(ide) fluorescence yield after a short light pulse represent a useful tool to monitor the kinetics of pigment-protein organization and primary thylakoid assembly triggered by Pchlide photoreduction. [less ▲]

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See detailTumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.
Louis, Edouard ULg; Franchimont, D.; Piron, Anne ULg et al

in Clinical & Experimental Immunology (1998), 113(3), 401-406

TNF-alpha is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-alpha production. This might determine a predisposition to develop some ... [more ▼]

TNF-alpha is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-alpha production. This might determine a predisposition to develop some complications or phenotypes of these diseases. The aims of our study were to assess the inter-individual variability of TNF-alpha production and to correlate this variability to a single base pair polymorphism located at position -308 in TNF gene. We studied 62 healthy individuals. TNF-alpha production after LPS stimulation was evaluated using a whole blood cell culture model. The TNF gene polymorphism was studied by an allele-specific polymerase chain reaction. Other cytokines produced in the culture, soluble CD14 concentrations and expression of CD14 on blood cells were also measured. Among the 62 individuals, 57 were successfully genotyped. There were 41 TNF1 homozygotes and 16 TNF1/TNF2 heterozygotes. TNF-alpha production after LPS stimulation of whole blood cell culture was higher among TNF2 carriers than among TNFI homozygotes (929pg/ml (480-1473pg/ml) versus 521 pg/ ml (178-1307 pg/ml); P<0.05). This difference was even more significant after correction of TNF-alpha production for CD14 expression on blood cells. In conclusion, the single base pair polymorphism at position -308 in the TNF gene may influence TNF-alpha production in healthy individuals. [less ▲]

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See detailLe rappresentazioni della relazione tra operatori e bambini autistici. Résultati di una ricerca.
D'Amore, Salvatore ULg; Onnis, Luigi

in Psicobiettivo (1998), 18(1), 103-121

Relationals representations constitute an important study area for understanding of interactive phenomena, especially, in the field of relationship between health care workers (medical doctors ... [more ▼]

Relationals representations constitute an important study area for understanding of interactive phenomena, especially, in the field of relationship between health care workers (medical doctors, psychotherapists, counsellors and so on) and patients because relational representations circularly influence mutual behaviours and expectations. This research suggests an observational model of the relational representations between a therapist and an autistic child. This model, based upon the use of metaphors and sculpting, put in evidence how the way the therapist represents the child and the relationship with him could have important implications on the therapeutic process as on its developments and issues. The subjectivity of the therapist and his personal aspects, consequently, become a crucial field of auto reflection: this requires adequate training courses and regular supervision experiences. [less ▲]

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See detailHemodynamic changes induced by laparoscopy and their endocrine correlates: effects of clonidine.
Joris, Jean ULg; Chiche, Jean-Daniel; Canivet, Jean-Luc ULg et al

in Journal of the American College of Cardiology (1998), 32(5), 1389-96

OBJECTIVES: We investigated endocrine correlates of the hemodynamic changes induced by carbon dioxide pneumoperitoneum (PNO). We then studied whether clonidine might modulate the hemodynamic changes ... [more ▼]

OBJECTIVES: We investigated endocrine correlates of the hemodynamic changes induced by carbon dioxide pneumoperitoneum (PNO). We then studied whether clonidine might modulate the hemodynamic changes induced by PNO by reducing release of catecholamines and vasopressin. BACKGROUND: Both mechanical and neurohumoral factors contribute to the hemodynamic changes induced by carbon dioxide PNO. Several mediators have been proposed, but no study has correlated hemodynamic changes with changes in levels of these potential mediators. METHODS: We conducted two studies, each including 20 healthy patients scheduled for elective laparoscopic cholecystectomy. In the first study serial measurements of hemodynamics (thermodilution technique) were done during laparoscopy and after exsufflation. Plasma concentrations of cortisol, catecholamines, vasopressin, renin, endothelin and prostaglandins were measured at the same time points. In the second study patients were randomly allocated to receive 8 microg/kg clonidine infused over 1 h or placebo before PNO. Hemodynamics and plasma levels of cortisol, catecholamines and vasopressin were measured during PNO and after exsufflation. RESULTS: Peritoneal insufflation resulted in a significant reduction of cardiac output (18+/-4%) and increases in mean arterial pressure (39+/-8%) and systemic (70+/-12%) and pulmonary (98+/-18%) vascular resistances. Laparoscopy resulted in progressive and significant increases in plasma concentrations of cortisol, epinephrine, norepinephrine and renin. Vasopressin plasma concentrations markedly increased immediately after the beginning of PNO (before PNO 6+/-4 pg/ml; during PNO 129+/-42 pg/ml; p < 0.05). The profile of vasopressin release paralleled the time course of changes in systemic vascular resistance. Prostaglandins and endothelin did not change significantly. Clonidine significantly reduced mean arterial pressure, heart rate and the increase in systemic vascular resistance. Clonidine also significantly reduced catecholamine concentrations but did not alter vasopressin and cortisol plasma concentrations. CONCLUSIONS: Vasopressin and catecholamines probably mediate the increase in systemic vascular resistance observed during PNO. Clonidine before PNO reduces catecholamine release and attenuates hemodynamic changes during laparoscopy. [less ▲]

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See detailExpression of Growth Hormone Receptors by Lymphocyte Subpopulations in the Human Tonsil
Thellin, Olivier ULg; Coumans, Bernard ULg; Zorzi, Willy ULg et al

in Developmental Immunology (1998), 6(3-4), 295-304

The ability of human tonsillar lymphoid cells to express growth hormone receptor (hGH-N-R) was analyzed by flow cytometry. FITC-coupled recombinant human growth hormone (hGH-N) was used to reveal the ... [more ▼]

The ability of human tonsillar lymphoid cells to express growth hormone receptor (hGH-N-R) was analyzed by flow cytometry. FITC-coupled recombinant human growth hormone (hGH-N) was used to reveal the receptors, in combination with phenotype markers. Unlike T cells, tonsillar B cells constitutively express the hGH-N receptor. Quiescent cells separated from activated cells by Percoll-gradient centrifugation bear fewer receptors than activated ones. Activated T cells express hGH-N-R, but the typical germinal centre CD4+ CD57+ T cells do not. These latter thus appear not to be fully activated. Inside the lymph follicles, the germinal centre CD38+ B-cell population and the mantle-zone CD39+ B-cell population display similar levels of hGH-N-R expression, but receptor density is lower on dividing dark-zone CD38+ CD10+ B cells. Different lymphoid-cell populations thus differ markedly in their ability to express the growth hormone receptor, in relation notably to their activation status. This highlights the link between the neuroendocrine system and the active immune defense. [less ▲]

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See detailNotre école offre-t-elle à tous les mêmes occasions d'apprendre?
Crahay, Marcel ULg

in Scientia Paedagogica Experimentalis (1998), 35(2), 381-418

Cet article présente les données de six études portant sur la gestion du temps scolaire en Communauté française de Belgique. Trois d'entre elles ont été menées dans des classes maternelles, deux dans des ... [more ▼]

Cet article présente les données de six études portant sur la gestion du temps scolaire en Communauté française de Belgique. Trois d'entre elles ont été menées dans des classes maternelles, deux dans des classes primaires et une au niveau secondaire. Les données ont été recueillies par observation directe dans cinq études et par l'intermediaire de rapports d'enseignant dans la sixième. L'analyse des résultats montre l'importante variabilité inter-classes du temps alloué aux différentes activités éducatives. Ce constat est valable pour tous les niveaux d'enseignement enquêtes. D'autres conclusions sont spécifiques au niveau d'enseignement. Au niveau préscolaire, il existe peu d'activités communes à toutes les classes (Ceci signifie que la nature du programme applique varie d'une classe a l'autre.) Au niveau primaire bien que le temps alloué aux différentes disciplines scolaires varie énormement d'une classe a l'autre, certaines tendances se dégagent : tous les enseignants consacrent aux mathématiques un temps superieur à ce qui est recommandé par le programme; l'enseignement de la grammaire débute en deuxieme année du primaire, alors que le programme fait démarrer cet apprentissage plus tard ; l'enseignement des sciences est negligé partout. Au niveau secondaire, on observe que les enseignants utilisent le temps de façon moins efficace dans les sections professionnelles que dans les sections générales. L'auteur avance que des systèmes de pilotage du rendement scolaire et des formules utilisant l'évaluation externe a des fins de régulation pourraient constituer une garantie d'égalité. [less ▲]

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See detailSystème rénine-angiotensine II-aldostérone: quoi de neuf en 1998?
Krzesinski, Jean-Marie ULg

in Médisphère (1998), 91(12-13),

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See detailPreserved artificial grammar learning in Parkinson's disease
Meulemans, Thierry ULg; Peigneux, Philippe ULg; Van der Linden, Martial ULg

in Brain & Cognition (1998), 37(1), 109-112

Parkinson's disease (PD) patients and matched control subjects were compared in an artificial grammar learning task. The test strings were constructed in such a way that grammaticality judgments could not ... [more ▼]

Parkinson's disease (PD) patients and matched control subjects were compared in an artificial grammar learning task. The test strings were constructed in such a way that grammaticality judgments could not be based on some superficial features of the learning strings: the grammatical and nongrammatical test strings did not differ according to different measures of chunk strength (based on the frequency with which their bigrams and trigrams appear in the learning strings). Results show that PD patients and controls performed at the same level during the first presentation of the test strings series, which suggests that the striatum is not (crucially) implicated in the ability to abstract rules implicitly from exemplars generated by a finite-state grammar. However, and contrary to control subjects, the classification performance of PD patients was at chance during the second presentation of the test strings. We argue that this latter result could be the consequence of the attentional deficit of PD patients. [less ▲]

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See detailLa régulation des cycles infectieux du virus de la varicelle et du zona
Piette, Jacques ULg; Defechereux-Thibaut de Maisières, Patricia; Baudoux-Tebache, Laurence et al

in M S-Médecine Sciences (1998), 14(5), 556-565

Varicella-zoster virus (VZV) is an Alphaherpesvirus responsible for two human diseases: primary exposure to the virus results in chicken pox (varicella) and reactivation following a period of latency in ... [more ▼]

Varicella-zoster virus (VZV) is an Alphaherpesvirus responsible for two human diseases: primary exposure to the virus results in chicken pox (varicella) and reactivation following a period of latency in dorsal lia gives rise to shingles (zoster). Interestingly, several transcripts corresponding to regulatory proteins present during the lytic cycle can be found in latently infected cells. The IE62 protein, component of the viral tegument, is a nuclear phosphoprotein. IE62 may play a crucial role in triggering and regulating the replicative cycle of VZV since it transactivates all classes of VZV genes and is able to repress or activate its own promoter. Moreover, IE62 acts in synergy with IE4, another important regulatory protein, to stimulate VZV gene promoters and IE62 is responsible for the translocation of IE4 from the cytoplasm to the nucleus. IE4 is expressed at very early times of the VZV productive cycle, Predominantly localized in the cytoplasm, IE4 activates several VZV genes, either alone or in synergy with IE62, as well as heterologous viral genes. At the molecular level, IE4 seems to act both transcriptionally and post-transcriptionally. Another major VZV protein is a 45 kDa phosphorylated protein, called IE63, which is abundantly expressed at the onset of the productive cycle. It is also defected during latency in humans and in a rat animal model an unexpected observation in Alphaherpesviruses. IE63 displays little direct effect on VZV gene promoters, it shows no inhibitory effect on the transactivating functions of IE62 but it represses the IE4 mediated activation. Studies conducted to define the mode of action of three VZV regulatory proteins playing crucial roles in the latency and reactivation of the am-rus mil not only lead to a better understanding of the virus pathogenesis but will probably help define novel therapeutic tools. [less ▲]

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See detailLes fossiles végétaux du Dévonien inférieur de Fooz-Wépion (bord nord du Synclinorium de Dinant, Belgique). IV. Deuterophyton stockmansii gen. et nov. sp.
Gerrienne, Philippe ULg

in Comptes Rendus de l'Académie des Sciences. Série II. Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (1998), 326

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See detailComparaison de l'utilisation de sciure ou d'un mélange paille-sciure comme substrat de litière accumulée pour porcs charcutiers
Nicks, Baudouin ULg; Desiron, A.; Canart, B.

in Annales de Zootechnie (1998), 47(2), 107-116

Two similar rooms were used to keep pigs on deep litter, one room with pigs on sawdust (litter S) and the other with pigs on a mixture of straw and sawdust with 50% dry matter (DM) of each material ... [more ▼]

Two similar rooms were used to keep pigs on deep litter, one room with pigs on sawdust (litter S) and the other with pigs on a mixture of straw and sawdust with 50% dry matter (DM) of each material (litter PS). Three batches of 17 pigs were reared in each room over the 14-month period of experiment. The deep litters were started with a bedding of about 30 cm. Afterwards the amounts of litters used were adjusted to keep the pigs clean. Each week the litter S was manually aerated and manure incorporated in the litter. This work was not per formed with the litter PS. Both temperatures, relative humidities and ventilation rates were similar in the two rooms. The temperatures in the litters were continuously recorded. Ammonia concentrations were measured once a week using 8-h diffusion tubes. Electrochemical probes were occasionally used to measure the NH3 concentrations continuously, at l-h intervals, during 1-week periods. NO concentrations were measured dul-ing all the experimental period with electrochemical probes. At the end of the experiment the amounts of litter DM used per pig were of 32 kg with the litter S and 40 kg with the litter PS. The litter temperatures measured at 20 cm depth varied between 30 and 37 degrees C. Heat evaporated the dung water and the DM content of the composts produced staid above 50%. The amounts of compost produced per fattening pig were of 127 kg with the litter S and of 157 kg with the litter PS. Corresponding amounts of N in the composts were of 1.38 and 1.92 kg/pig, respectively. NH3 emission was lower from litter S than from litter PS but small increases of NH3 concentration until 50 ppm were observed during the work of aeration. Adding new litter decreased the emissions. NO emissions were only observed with the litter S, during the aeration period. Pig performance and carcass qualities were not affected by the litter mate. [less ▲]

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See detailHerpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Acta Dermato Venereologica (1998), 78

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See detailLe bilan biologique de base, un examen inutile
Roland, Michel; Jamoulle, Marc ULg

in Revue Médicale de Bruxelles (1998), 19(4), 255-262

A critical analysis of the theoretical concepts applying to mass screening (Frames' criteria) in relation with the "Evidence-Based Medicine" methodology leads to rule out the basic blood test from the ... [more ▼]

A critical analysis of the theoretical concepts applying to mass screening (Frames' criteria) in relation with the "Evidence-Based Medicine" methodology leads to rule out the basic blood test from the periodic health examination. A good questioning with a good clinical examination will select high risk populations for specific health problems for which some oriented tests can be performed with an acceptable positive predictive value. [less ▲]

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See detailComparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques.
Bruhwyler, J.; Liégeois, Jean-François ULg; Gerardy, J. et al

in Behavioural Pharmacology (1998), 9(8), 731-7

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic ... [more ▼]

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic pirlindole (a selective and reversible MAO-A inhibitor) and its two enantiomers using biochemical techniques (in vitro and ex vivo determination of rat brain MAO-A and MAO-B activity) and behavioural models (forced swimming test and reserpine-induced hypothermia and palpebral ptosis test). In vitro, the MAO-A IC50 of (+/-)-pirlindole, R-(-)-pirlindole and S-(+)-pirlindole were 0.24, 0.43 and 0.18 microM, respectively. Ex vivo, their ID50 were 24.4, 37.8 and 18.7 mg/kg i.p. The differences between the three compounds were not significant, with a ratio between the two enantiomers [R-(-)/S-(+)] of 2.2 in vitro and 2.0 ex vivo. MAO-B was only slightly inhibited. In the forced swimming test and the reserpine-induced hypothermia and ptosis model, the three compounds had an antidepressant profile. In the forced swimming test, the minimal effective dose ratio between the R-(-) and the S-(+) was again around 2.0. The behavioural observations were thus clearly in accordance with the biochemical data. [less ▲]

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See detailPurification of myeloperoxidase from equine polymorphonuclear leucocytes.
Mathy, Marianne ULg; Bourgeois, E.; Grulke, Sigrid ULg et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1998), 62(2), 127-32

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute ... [more ▼]

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute inflammation). To develop an assay for measurement of plasma MPO in horses during the above-mentioned infectious and inflammatory conditions, MPO was purified from equine PMN isolated from blood anticoagulated with citrate. PMN were extracted in a saline milieu (0.2 M Na acetate, 1 M NaCl, pH 4.7) to eliminate most of cellular proteins. Pellets were then extracted in the same buffer containing cationic detergent (1% cetyltrimethyl ammonium bromide). The supernatant was further purified by ion exchange chromatography (Hiload S Sepharose HP column 0.5 x 26 cm, equilibrated with 25 mM Na acetate, 0.2 M NaCl, pH 4.7) with a NaCl gradient (until 1 M). Most of the peroxidase activity of MPO (spectrophotometrically measured by the oxidation of orthodianisidine by hydrogen peroxide) was eluted at 0.65 M NaCl. MPO was further purified by gel filtration chromatography (Sephacryl S 200 column 2.6 x 42 cm with 25 mM Na acetate, 0.2 M NaCl, pH 4.7). MPO (specific activity: 74.3 U/mg) was obtained with a yield of 30% from the detergent extraction supernatant. Electrophoresis (non-reducing conditions) showed 3 bands identified, by comparison with human MPO, (i) the mature tetrameric enzyme (150 kDa) with 2 light and 2 heavy subunits, (ii) the precursor form (88 kDa) and (iii) a form of the heavy subunit without the prosthetic heme group (40 kDa). The mature enzyme and its precursor were glycosylated and possessed peroxidase activity. Equine MPO showed strong similarities with human and bovine MPO, with an absorption peak at 430 nm (Soret peak) characteristic of ferrimyeloperoxidase. Enzymatic activity was pH dependent (optimal value at pH 5.5). [less ▲]

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See detailDetermination of the total glucosinolate content in rapeseed seeds by liquid chromatography: comparative study between the rapid isocratic and the reference gradient methods by a ring test
Quinsac, A.; Krouti, M.; Ribaillier, D. et al

in Ocl-Oleagineux Corps Gras Lipides (1998), 5(5), 398-406

Isocratic liquid chromatography (LC) on cyanopropyl bonded silica column is an alternative method to gradient IC on octadecyl bonded silica column involved in the standardized method for total ... [more ▼]

Isocratic liquid chromatography (LC) on cyanopropyl bonded silica column is an alternative method to gradient IC on octadecyl bonded silica column involved in the standardized method for total glucosinolotes (GSL) analysis in rapeseed seeds. Its advantages consist in more simple apparatus and eluent, and a shorter analysis duration. In the aim of a next standardization of isocratic LC, the performances of both methods ore compared on three rapeseed samples during a ring-test including six laboratories. Statistical treatment or the results according to ISO 5725 shows, with a risk level of 5%, the equivalency of both methods to determine total GSL content in rapeseed seeds. The elution mode appears to have no significant effect on results in opposite to the internal standard when its purity is not well-known. [less ▲]

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See detailLa succession des régions aux obligations aquiliennes de l'Etat relatives à la voirie
Delnoy, Michel ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

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See detailParticipation et aménagement empathique. Réflexions à partir du cas wallon.
Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (1998), 34

Town and country planning also involves care of individual "territories" as well as those of groups and societies. After a brief recapitulation of motivations for and objections to taking into account ... [more ▼]

Town and country planning also involves care of individual "territories" as well as those of groups and societies. After a brief recapitulation of motivations for and objections to taking into account citizen's expectations concerning "territorial" planning this paper illustrates the situation in Wallonia. Three types of planning are illustrated : pure theoretical planning, participatory planning and empathic planning. Finally, the paper underlies the challenges facing public services, education and research wich must be addressed if empathic and effective planning is to be implemented. [less ▲]

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See detailReconnaissance of the main Black Sea's ecohydrodynamics by means of a 3D interdisciplinary model
Grégoire, Marilaure ULg; Beckers, Jean-Marie ULg; Nihoul, Jacques ULg et al

in Journal of Marine Systems (1998), 16(1-2), 85-105

A 3D interdisciplinary model has been used to test the sensitivity of the Black Sea’s ecosystem to physical processes. The hydrodynamical model of the general circulation has been built up, using the GHER ... [more ▼]

A 3D interdisciplinary model has been used to test the sensitivity of the Black Sea’s ecosystem to physical processes. The hydrodynamical model of the general circulation has been built up, using the GHER primitive equation model. A model with 15 km horizontal resolution and 25 vertical levels is used to compute the typical seasonal cycle. The model is forced by climatological monthly mean fields of temperature, salinity and wind stress at the air–sea interface; the river discharges of the Danube, Dnestr and Dnepr are taken into account. An ecosystem model at basin scale is then defined by a nitrogen cycle considering several phytoplankton and zooplankton sizes and including the microbial loop. The ecosystem model is embedded on-line into the 3D hydrodynamical model with a superimposed cycle for the light intensity. This model must be regarded rather as a first tool for testing the coupling of hydrodynamic and ecosystem submodels, while acquiring some preparatory assessment of the effect of physical processes on the ecodynamics. The results display a highly three-dimensional aspect with important horizontal and vertical variations, obviously imparted to the system by the physical processes horizontal and vertical advection, vertical mixing and diffusion, upwelling associated with light limitation at depth and sinking of dead organisms. In this paper, the results are described emphasizing the effects of the hydrodynamic constraints on the space–time distribution of the primary and secondary production. [less ▲]

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See detailStress coupling between earthquakes in Northwest Turkey and the North Aegean Sea
Nalbant, Süleyman; Hubert, Aurelia ULg; King, G. C. P.

in Journal of Geophysical Research (1998), 103

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See detailOsteochondrosis lesion of the lombo-sacral joint in a mastiff
Snaps, Frédéric ULg; Heimann, M.; Saunders, J. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(17), 476-477

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See detailComparaison des peuplements de diatomées épilithiques de ruisseaux acides en milieu forestier soumis à un amendement de dolomie (Massif Ardennais, Belgique)
Loncin, Anne; Leclercq, Louis ULg; Carnol, Monique ULg et al

in Annales de Limnologie (1998), 34(1), 13-22

Three to five years following application of dolomite (calcium magnesium carbonate) on some forest catchments in the belgian area of the Ardenne, epilithic diatoms were sampled in two streams running on ... [more ▼]

Three to five years following application of dolomite (calcium magnesium carbonate) on some forest catchments in the belgian area of the Ardenne, epilithic diatoms were sampled in two streams running on treated sites and in two streams running on untreated sites in order to evaluate the possible changes in the algal population. Typical acid water assemblages with Eunotia were observed. The dominant species was Eunotia exigua often found with E. rhomboidea or E. bilunaris. In the present study, no influence of the treatment can be demonstrated using these bioindicators. [less ▲]

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See detailInductively coupled plasma-mass spectrometric (ICP-MS) analysis of silicate rocks and minerals
Vander Auwera, Jacqueline ULg; Bologne, Guy; Roelandts, Iwan et al

in Geologica Belgica (1998), 1

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See detailShear-induced order in aqueous micellar solutions of amphiphilic poly(tert-butylstyrene)-b-poly(Na methacrylate) diblock
Leyh, Bernard ULg; Creutz, S.; Gaspard, J. P. et al

in Macromolecules (1998), 31(26), 9258-9264

Shear-induced order of aqueous micellar solutions of a poly(tert-butylstyrene)-b-poly(sodium methacrylate) diblock (c ) 2.5-15 w/v %) has been investigated by small-angle X-ray scattering. Data collected ... [more ▼]

Shear-induced order of aqueous micellar solutions of a poly(tert-butylstyrene)-b-poly(sodium methacrylate) diblock (c ) 2.5-15 w/v %) has been investigated by small-angle X-ray scattering. Data collected from a Couette cell in both radial and tangential geometries agree with a crystalline ordering of micelles in close packed hexagonal layers perpendicular to the velocity gradient, when c is in the 5-10 w/v % range. The measured interlayer distance is indeed very close to the value expected for a closepacked structure. The experimental data are consistent with a zigzag motion of adjacent planes upon shear. Shear-induced order is, however, restricted to a narrow concentration range just above the concentration for the sol-gel transition. This domain is thought to correspond to a regime where relative layer translation modes are allowed whereas mutual rotation is hindered. [less ▲]

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See detailBelgium : a planning environment both rigid and flexible
Merenne-Schoumaker, Bernadette ULg

in European Retail Digest (1998), (20), 29-30

Short notice on commercial planning in Belgium in a comparative perspective with other European countries analyzed in the same publication

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See detailBronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bone marrow transplantation.
Baron, Frédéric ULg; Hermanne, Jean-Philippe; Dowlati, A. et al

in Bone Marrow Transplantation (1998), 21(9), 951-4

A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT ... [more ▼]

A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT) from an HLA-matched brother who suffered from severe Crohn's disease. BOOP occurred 20 days after idiopathic interstitial pneumonia, in the context of severe ulcerative colitis. Lung and colon biopsies showed no signs of CMV infection or GVHD. The patient was treated with oral methylprednisolone 1 mg/kg/day and his clinical status and chest X-ray improved slowly. Remarkably, the symptoms of colitis also resolved with prednisone therapy and he is now symptom-free. We hypothesize that ulcerative colitis may have been transmitted from donor to recipient (adoptive autoimmunity) and that it was complicated by BOOP. However, other factors such as CMV may have contributed to the occurrence of BOOP. [less ▲]

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See detailLiver assist systems: state of the art.
Arkadopoulos, N.; Detry, Olivier ULg; Rozga, J. et al

in International Journal of Artificial Organs (1998), 21(12), 781-7

Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with ... [more ▼]

Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with liver tissue. However, no system has achieved wide clinical use and - in the absence of liver transplantation - severe hepatic failure continues to be associated with significant morbidity and mortality. In this paper, the authors review the current status of liver assist systems and summarize their clinical experience with a xenogeneic cell based-bioartificial liver. [less ▲]

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See detailLes moines face à l'éternité
George, Philippe ULg

in Moyen Age (Le) (1998), CIV

article bibliographique

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See detailTarifs de cubage et paramètres de forme. L'aulne glutineux.
Rondeux, Jacques ULg; Lejeune, Philippe ULg; Thibaut, André et al

in Silva Belgica (1998), 105(6), 7-12

Dans le cadre de cette recherche dont l'un des objectifs finaux est la construction de modèles de croissance, une première étape a été consacrée à l'établissement de tarifs de cubage d'arbres appropriés à ... [more ▼]

Dans le cadre de cette recherche dont l'un des objectifs finaux est la construction de modèles de croissance, une première étape a été consacrée à l'établissement de tarifs de cubage d'arbres appropriés à l'aulne glutineux et à la région de croissance étudiée. Cette démarche était d'autant plus utile que très peu de travaux dendrométriques sont disponibles pour cette essence en Europe. [less ▲]

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See detailIron metabolism and erythropoiesis after surgery.
van Iperen, C. E.; Kraaijenhagen, Rob J.; Biesma, D. H. et al

in British Journal of Surgery (1998), 85(1), 41-5

BACKGROUND: This was a prospective study comparing the effect of major and minor surgery on haematological variables concerning erythropoiesis, iron metabolism and acute-phase response proteins. METHODS ... [more ▼]

BACKGROUND: This was a prospective study comparing the effect of major and minor surgery on haematological variables concerning erythropoiesis, iron metabolism and acute-phase response proteins. METHODS: Thirty-one otherwise healthy patients, 15 having major orthopaedic surgery and 16 undergoing minor surgery, were studied. Blood samples were taken before surgery and 1, 4, 10 and 28 days after operation. RESULTS: Haemoglobin concentration was decreased for up to 4 weeks after surgery. Serum erythropoietin concentration and reticulocyte count were raised after major surgery only. Serum iron concentration dropped the day after major (to 23 per cent of its preoperative level) and minor (to 46 per cent of its preoperative level) surgery and remained lower for up to 28 days after major surgery. Serum transferrin concentration and transferrin saturation decreased after both types of surgery while ferritin concentration increased. Serum transferrin receptor concentration increased only 4 weeks after major surgery (P < 0.01). The interleukin 6 peak (day 1) was greater after major than minor surgery, as was the C-reactive protein peak (day 4). CONCLUSION: Both major and minor surgery induce a state of hypoferraemia in the presence of adequate iron stores. The degree of this transient form of 'anaemia of chronic disease' is related to the extent of surgery. Iron supplementation in the first weeks after surgery (if iron stores were normal before operation) is ineffective. [less ▲]

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See detailThe prediction of preeclampsia: Reassessment of clinical value of increased plasma levels of fibronectin
Dreyfus, M.; Baldauf, J. J.; Ritter, J. et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (1998), 78

Objective: To determine whether assessment of plasma fibronectin in primigravidae could predict the pregnant women expected to become preeclamptic. Methods: We performed a prospective blinded analysis of ... [more ▼]

Objective: To determine whether assessment of plasma fibronectin in primigravidae could predict the pregnant women expected to become preeclamptic. Methods: We performed a prospective blinded analysis of 156 apparently normotensive primigravidae in an outpatient clinic. Blood samples were taken at 6 week intervals from the 18th week and immediately after delivery or at the onset of preeclampsia. Plasma fibronectin was evaluated by ELISA. Evolution with gestational age was studied using regression curves. Results: We had 148 normal primigravidae (592 determinations). In three women, increased fibronectin anticipated preeclampsia by 3–4 weeks. Five women showed high levels only at the onset of preeclampsia. Sensitivity, specificity, positive and negative predictive values of increased fibronectin levels were 37.5% (95% CI53.3–71.7), 96.6% (95% CI593.7–99.6), 37.5% (95% CI53.3–71.7) and 96.6% (95% CI593.7–99.6), respectively. Conclusions: This study shows that plasma fibronectin levels could represent a specific marker for preeclampsia. Its sensitivity has to be improved but its high negative predictive value strongly argues against the development of preeclampsia within the next 4 weeks after the blood sampling. [less ▲]

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See detailShoshonitic liquid line of descent from diorite to granite: the Late Precambrian post-collisional Tismana pluton (South Carpathians, Romania)
Duchesne, Jean-Clair ULg; Berza, Tudor; Liégeois, Jean-Paul ULg et al

in Lithos (1998), 45

The post-collision late-kinematic Tismana pluton belongs to the shoshonitic series. It is part of a Late Precambrian basement within the Alpine Danubian nappes of the South Carpathians (Romania). This ... [more ▼]

The post-collision late-kinematic Tismana pluton belongs to the shoshonitic series. It is part of a Late Precambrian basement within the Alpine Danubian nappes of the South Carpathians (Romania). This pluton displays an exceptionally complete range of compositions from ultramafic to felsic rocks (granites). Widespread mingling/mixing relationships at all scales give rise to a variety of facies. A liquid line of descent from the diorites to the granites is reconstructed by considering the variation in major and trace elements (REE, Sr, Rb, Ba, Nb, Zr, Hf, Zn, V, Co, Cr, U, Th, Ga, Pb) from 33 selected samples as well as mineral/melt equilibrium relationships. The first step of fractional crystallization is the separation from a monzodioritic parent magma of a peridotitic cumulate similar to the ultramafic rock found in the massif. A possible contamination by lower crustal mafic component takes place at this stage. The second step marks the appearance of apatite and Fe-Ti oxide minerals as liquidus phases, and the third step, saturation of zircon. Mixing by hybridisation of magmas produced at different stages of the evolution along the liquid line of descent is also operating (endo-hybridisation). As depicted by Nd and Sr isotopes, fractional crystallization was combined to an important early contamination by a mafic lower crust in a deep-seated magma chamber and to a later and mild contamination by a felsic medium crust in an intermediate chamber. The mingling essentially occurred during the final emplacement in the high-level magma chamber. The monzodioritic parent magma, identified by major and trace element modelling, is shown by Sr and Nd isotopes to have its source in the lithospheric mantle or in a juvenile mafic lower crust derived from it. The necessarily recent enrichment in K2O and associated elements of the lithospheric mantle is likely to be related to the preceding Pan-African subduction period. The partial melting of this newly formed deep source has to be linked to a major change in the thermal state of the plate. [less ▲]

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See detailEvidence for behavioral sensitization to cocaine in preweanling rat pups
Wood, R. D.; Tirelli, Ezio ULg; Snyder, K. J. et al

in Psychopharmacologia (1998), 138(2), 114-123

Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to ... [more ▼]

Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to postnatal day 20 with 0, 5, 15, or 30 mg/kg cocaine hydrochloride and placed for 30 min in either the experimental chamber or home cage. On postnatal day 21 (test day), Ss were challenged with either 15 mg/kg cocaine or saline prior to placement in the experimental chamber. Significant sensitization of cocaine-induced stereotyped head movements was evident in animals given 15 or 30 mg/kg chronically in the experimental chamber, but not when these same doses were given in the home cage. Less consistent evidence for cocaine-induced sensitization was seen when examining locomotion, although trends for sensitization of this behavior were seen in animals chronically injected in either the test chamber or home cage. Thus, preweanlings can exhibit cocaine sensitization, particularly in terms of stereotypy, when tested shortly after the chronic exposure period, with expression of this sensitization being facilitated by pairing the chronic injections with the test context. ((c) 1998 APA/PsycINFO, all rights reserved) [less ▲]

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See detailThe C-terminal helix of human apolipoprotein AII promotes the fusion of unilamellar liposomes and displaces apolipoprotein AI from high-density lipoproteins.
Lambert, Géraldine ULg; Decout, A.; Vanloo, B. et al

in European Journal of Biochemistry (1998), 253(1), 328-38

To assess the functional properties of apolipoprotein (apo) AII and to investigate the mechanism leading to the displacement of apo AI from native and reconstituted high-density lipoproteins (HDL and r ... [more ▼]

To assess the functional properties of apolipoprotein (apo) AII and to investigate the mechanism leading to the displacement of apo AI from native and reconstituted high-density lipoproteins (HDL and r-HDL) by apo AII, wild-type and variant apo AII peptides were synthesized. The wild-type peptides, residues 53-70 and 58-70, correspond to the C-terminal helix of apo AII and are predicted to insert at a tilted angle into a lipid bilayer. We demonstrate that both the apo AII-(53-70) peptide, and to a lesser extent the apo AII-(58-70) peptide are able to induce fusion of unilamellar lipid vesicles together with membrane leakage, and to displace apo AI from HDL and r-HDL. Two variants of the apo AII-(53-70)-wild-type (WT) peptide, designed either to be parallel to the water/lipid interface [apo AII-(53-70)-0 degrees] or to retain an oblique orientation [apo AII-(53-70)-30 degrees], were synthesized in order to test the influence of the obliquity on their fusogenic properties and ability to displace apo AI from HDL. The parallel variant did not bind lipids, due to its self-association properties. However, the apo AII-(53-70)-30 degrees variant was fusogenic and promoted the displacement of apo AI from HDL. Moreover, the extent of fusion of the apo AII-(53-70)-WT, apo AII-(58-70)-WT and apo AII-(53-70)-30 degrees peptides was related to the alpha-helical content of the lipid-bound peptides measured by infrared spectroscopy. Infrared measurements using polarized light also confirmed the oblique orientation of the helical component of the three peptides. In native and r-HDL, the tilted insertion of the C-terminal helix of apo AII resulting in a partial destabilization of the HDL external lipid layer might contribute to the displacement of apo AI by apo AII. [less ▲]

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See detailCortical electrophysiology in migraine and possible pathogenetic implications
Schoenen, Jean ULg

in Clinical Neuroscience (New York, N.Y.) (1998), 5

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See detailTrophic relationships within intertidal communities of the Brittany coast: a stable carbon isotope analysis
Dauby, Patrick ULg; Khomsi, Ahmid; Bouquegneau, Jean-Marie ULg

in Journal of Coastal Research (1998), 14

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See detailQuarante ans d'exécution de remembrements ruraux en Région wallonne.
Schmitz, Serge ULg; Christians, Charles ULg

in Acta Geographica Lovaniensia (1998), 37

For forty years, a third of the farming area has been regrouped in Wallonia. The paper draws the development of land consolidation and underlines the increase of non agricultural aims, especially ... [more ▼]

For forty years, a third of the farming area has been regrouped in Wallonia. The paper draws the development of land consolidation and underlines the increase of non agricultural aims, especially environment concerns. So land consolidations with stark productivity concerns in the sixties changed to a new way of land consolidation respectful of the inherited balances and concerned with the functional diversification of the rural areas. However the distribution of land consolidation projects still shows stark productivity concerns : land consolidation projects remain first in ploughed land areas with large farming. [less ▲]

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See detailNouvelles données lithostratigraphiques sur le Frasnien de l'Anticlinorium de Philippeville
Dumoulin, V.; Marion, Jean-Marc ULg; Boulvain, Frédéric ULg et al

in Annales de la Société Géologique du Nord (1998), II 6

The revision of the Sautour-Surice geological map revealed some important lateral facies variations in the Frasnian of the Philippeville Massif. Two kinds of lithological successions have been observed ... [more ▼]

The revision of the Sautour-Surice geological map revealed some important lateral facies variations in the Frasnian of the Philippeville Massif. Two kinds of lithological successions have been observed, corresponding to the formations newly defined in the Philippeville Massif (proximal facies) and at the southern border of the Dinant Synclinorium (distal facies). The geographic repartition of the two facies is schematically presented. A new section (distal facies) is described from the Hermeton valley (SE of the Philippeville Massif). As a conclusion, the origin of the coexistence of the two facies types in the Philippeville Massif is discussed. [less ▲]

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See detailPhenologie des Basidiomycetes lignicoles de l'ile de Laing (Papouasie Nouvelle-Guinee)
Castillo Cabello, Gabriel ULg; Demoulin, Vincent ULg

in Belgian Journal of Botany (1998)

In the framework of a study of wood-inhabiting fungi on Laing Island, a small coral island located on the northern coast of Papua New Guinea, we have established a phenological table of the 96 taxa of ... [more ▼]

In the framework of a study of wood-inhabiting fungi on Laing Island, a small coral island located on the northern coast of Papua New Guinea, we have established a phenological table of the 96 taxa of encountered Basidiomycetes. Within six species presenting large phenological amplitude, two groups can be distinguished. On the one hand a group of species (Hexagonia tenuis, Polyporus philippinensis and Microporus xanthopus) with narrow ecological amplitude restricted to dense vegetation cover and thus growing in an environment buffered against desiccation and on the other hand a group of species (Pycnoporus sanguineus, Schizophyllum commune and Trametes scabrosa) with a very large ecological amplitude very resistant to desiccation. Furthermore, a large number of species are found too sporadically in order to draw some conclusions concerning their phenology. [less ▲]

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See detailadaptation in neonatalogy of the once-daily concept of aminoglycoside administration: evaluation of a dosing chart for amikacin in an intensive care unit.
Langhendries, JP; Battisti, Oreste ULg; Bertrand, J. M. et al

in Biology of the Neonate (1998), 74

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See detailbeta-lactamases as models for protein-folding studies
Vanhove, M.; Lejeune, Annabelle ULg; Pain, R. H.

in Cellular and Molecular Life Sciences : CMLS (1998), 54(4), 372-377

This review traces some of the key features of the folding of beta-lactamases and their relevance to the way proteins fold in general. Studies on the enzymes have highlighted the nature and role of ... [more ▼]

This review traces some of the key features of the folding of beta-lactamases and their relevance to the way proteins fold in general. Studies on the enzymes have highlighted the nature and role of equilibrium and transient condensed states. The kinetics of folding are multiphasic, and when monitored by acrylamide quenching of the tryptophan fluorescence, an early phase provides evidence for the transient accumulation of a nonnative intermediate involving burial of tryptophan in a nonpolar environment. Intermediate phases can be understood in terms of progressive folding of different parts of the molecule. The later, slow phases are associated with proline isomerization in the TEM-1 enzyme and, in its P167T mutant form, with isomerization from trans to cis of the E166 T167 peptide bond. Coupled with kinetic and X-ray crystallographic studies of the beta-lactamase from Staphylococcus aureus and its D179Q mutant, it appears that the final stage of folding is that of collapse and packing of the Omega-loop on to the main body of the protein. [less ▲]

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See detailGrowth and fate of PSA-NCAM+ precursors of the postnatal brain
Ben Hur, Tamir; Rogister, Bernard ULg; Murray, Kerren et al

in Journal of Neuroscience (1998), 18

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See detailPrediction of response to optimize outcome of treatment with erythropoietin.
Beguin, Yves ULg

in Seminars in Oncology (1998), 25(3 Suppl 7), 27-34

Recombinant human erythropoietin (EPO; epoetin) has been shown to be effective in improving anemia in a proportion of cancer patients. The response rate is approximately 60%, but varies considerably ... [more ▼]

Recombinant human erythropoietin (EPO; epoetin) has been shown to be effective in improving anemia in a proportion of cancer patients. The response rate is approximately 60%, but varies considerably according to baseline hematocrit and transfusion needs, as well as the response criteria used. Response is not greatly influenced by the type of tumor, except in situations of major marrow involvement and limited residual hematopoiesis, or in the presence of specific mechanisms of anemia, such as hemolysis, splenomegaly, bleeding, hemodilution, or ineffective erythropoiesis. Stem cell damage by previous therapy as well as marrow suppression by current intensive chemotherapy can impair response. Besides its intensity, the type of chemotherapy may not be critical, although patients undergoing platinum-based chemotherapy may respond faster than those receiving non-platinum regimens. Complications, such as infections, bleeding, or nutritional deficiencies, may have a major negative impact on outcome. An important response-limiting factor is functional iron deficiency (ie, an imbalance between iron needs in the erythropoietic marrow and iron supply), which depends on the level of iron stores and its rate of mobilization. Functional iron deficiency is best monitored by the percentage of hypochromic red blood cells, and oral or intravenous iron supplements should be given when this percentage increases above 10%. All these factors explain why the response rate to epoetin is only approximately 60%. Therefore, it would be interesting to develop models that could help predict response to epoetin to help select the most appropriate cancer patients for this therapy. Few baseline parameters have been shown to be highly predictive of response in patients with solid tumors, although most studies in patients with myeloma or lymphoma have indicated that patients with a low baseline serum EPO level will respond better. Early changes after 2 to 4 weeks of treatment are also of great interest. Among these early changes, increments of soluble transferrin receptor, reticulocytes, and hemoglobin, as well as the persistence of elevated ferritin or EPO levels, have all shown some predictive value. Combination of baseline serum EPO and the 2-week increment of soluble transferrin receptor or hemoglobin may provide the best prediction of response. [less ▲]

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See detailLaser-assisted dielectronic recombination in C4+ ions
Bachau, H.; Gayet, R.; Lambropoulos, P. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1998), 31(14), 3263-3280

We study the effect of laser-driven transitions between autoionizing resonances on the dielectronic recombination rates observed after the formation of such resonances in electron-ion collisions. The ... [more ▼]

We study the effect of laser-driven transitions between autoionizing resonances on the dielectronic recombination rates observed after the formation of such resonances in electron-ion collisions. The autoionizing states of S-1(e) and P-1(0) symmetry belonging to the 2l2l' and 2l3l' configurations of C4+ are considered. The resonance parameters are calculated in the Feshbach formalism and compared with other accurate calculations, and transition dipole moments between the autoionizing states are obtained. The rates of dielectronic recombination and autoionization under the influence of the laser field are calculated using the density matrix approach for realistic parameters. A simple formulation of the problem is also proposed in the resolvent operator technique. The feasibility of an experiment is discussed. [less ▲]

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See detailApplication d'un SIG à la révision du parcellaire dans le cadre d'aménagements forestiers intégrés
Bousson, Emmanuelle; Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(4), 271-279

Under intensive silviculture, forest management is based upon the delimitation of compartments (management units) usually defined as reasonably homogeneous stands regarding ecological, biological and ... [more ▼]

Under intensive silviculture, forest management is based upon the delimitation of compartments (management units) usually defined as reasonably homogeneous stands regarding ecological, biological and silvicultural conditions. Forest lands can often be managed for several uses, sometimes on the same area or sometimes with different dominant uses assigned to separate areas. A forest managed primarily for timber production can also serve other purposes. In that respect, it is often necessary to readjust the limits of management units so that environmental constraints (soil erosion, watershed protection) are taken into account. These considerations require specific silviculture. A geographic information system (GIS) is used to overlay provisional compartments map (management units) and different thematic maps that describe areas where environmental constraints are identified. Informations about these areas located inside the compartments are used in a classification process to decide which orientation is the most suitable allocation (in terms of objectives) for each management unit: timber production or protection (humid soils, slopes, rivers and sources). This process also indicates what are the limits of units that can or have to be modified. Such a classification has to be considered as a guide to build the final limits of management units according to the environmental criteria defined as a preliminary. The proposed methodology is applied to a 400 hectares forest. [less ▲]

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See detailPour une grammaire du troisième type
Dumortier, Jean-Louis ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1998), 41-42

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See detailTreatment of anemia in myelodysplastic syndromes with granulocyte colony-stimulating factor plus erythropoietin: results from a randomized phase II study and long-term follow-up of 71 patients.
Hellstrom-Lindberg, E.; Ahlgren, T.; Beguin, Yves ULg et al

in Blood (1998), 92(1), 68-75

Treatment with erythropoietin (epo) may improve the anemia of myelodysplastic syndromes (MDS) in approximately 20% of patients. Previous studies have suggested that treatment with the combination of ... [more ▼]

Treatment with erythropoietin (epo) may improve the anemia of myelodysplastic syndromes (MDS) in approximately 20% of patients. Previous studies have suggested that treatment with the combination of granulocyte colony-stimulating factor (G-CSF) and epo may increase this response rate. In the present phase II study, patients with MDS and anemia were randomized to treatment with G-CSF + epo according to one of two alternatives; arm A starting with G-CSF for 4 weeks followed by the combination for 12 weeks, and arm B starting with epo for 8 weeks followed by the combination for 10 weeks. Fifty evaluable patients (10 refractory anemia [RA], 13 refractory anemia with ring sideroblasts [RARS], and 27 refractory anemia with excess blasts [RAEB]) were included in the study, three were evaluable only for epo as monotherapy and 47 for the combined treatment. The overall response rate to G-CSF + epo was 38%, which is identical to that in our previous study. The response rates for patients with RA, RARS, and RAEB were 20%, 46%, and 37%, respectively. Response rates were identical in the two treatment groups indicating that an initial treatment with G-CSF was not neccessary for a response to the combination. Nine patients in arm B showed a response to the combined treatment, but only three of these responded to epo alone. This suggests a synergistic effect in vivo by G-CSF + epo. A long-term follow-up was made on 71 evaluable patients from both the present and the preceding Scandinavian study on G-CSF + epo. Median survival was 26 months, and the overall risk of leukemic transformation during a median follow-up of 43 months was 28%. Twenty patients entered long-term maintenance treatment and showed a median duration of response of 24 months.The international prognostic scoring system (IPSS) was effective to predict survival, leukemic transformation, and to a lesser extent, duration of response, but had no impact on primary response rates. [less ▲]

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See detailPrimary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and role of radiotherapy and chemotherapy
Li, Y-X; COUCKE, Philippe ULg; Li, J-Y et al

in International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society (1998), 83(3), 449-456

BACKGROUND. This study was conducted to determine whether the paranasal extension of a primary non-Hodgkin’s lymphoma (NHL) of the nasal cavity has any deleterious effect on patient outcome. METHODS. One ... [more ▼]

BACKGROUND. This study was conducted to determine whether the paranasal extension of a primary non-Hodgkin’s lymphoma (NHL) of the nasal cavity has any deleterious effect on patient outcome. METHODS. One hundred and seventy-five patients with previously untreated nasal NHL were reviewed. There were 2 with low grade, 107 with intermediate grade, 17 with high grade, and 49 with unclassifiable lymphomas. In 48 cases the immunophenotype was available and 46 were T-cell lymphoma. According to the Ann Arbor system, there were 133 patients with Stage IE, 28 with Stage IIE, 4 with Stage IIIE, and 10 with Stage IVE lymphomas. Stage IE was subdivided into limited Stage IE (i.e., confined to the nasal cavity [67 patients]) or extensive Stage IE (i.e., presenting with extension beyond the nasal cavity [66 patients]). For patients with limited Stage IE disease the treatment of choice was radiotherapy with or without chemotherapy. In patients with extensive Stage IE disease, treatment was comprised of a combination of chemotherapy and radiotherapy or radiotherapy alone. For patients with a more advanced stage of disease (IIE–IVE), chemotherapy was an integral part of the treatment and was completed by irradiation, especially for patients with Stage IIE disease. RESULTS. The actuarial overall survival (OS) and disease free survival (DFS) rates at 5 years for the whole group were 65% and 57%, respectively. The 5-year OS and DFS rates were influenced by stage, with a gradual decrease from 75% and 68% for Stage IE disease to 35% and 28% for Stage IIE disease, and 31% and 19% for Stage IIIE/IVE disease. Patients with limited Stage IE disease survived significantly longer (90% 5-year OS) compared with those with extensive Stage IE disease (57% 5-year OS; P , 0.001). For 67 patients with limited Stage IE disease, the 5-year OS was 89% with radiotherapy alone and 92% with radiotherapy and chemotherapy, whereas for 66 patients with extensive Stage IE disease, the 5-year OS was 54% with radiotherapy and 58% with combined modality therapy or chemotherapy (P . 0.05). CONCLUSIONS. The prognosis of patients with primary NHL of the nasal cavity is stage dependent. In this large cohort of Stage IE patients, it was demonstrated that the paranasal local extension was a significant prognostic factor associated with poorer treatment outcome. The authors believe that Ann Arbor Stage IE should be subclassified further into limited and extensive Stage IE. The addition of chemotherapy did not appear to modify significantly the survival of patients with either limited or extensive Stage IE disease. The extranodal progression observed in patients with extensive Stage IE and Stage IIE-IVE disease clearly illustrates the need for improvement of systemic treatment. Cancer 1998;83:449–56. [less ▲]

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See detailLe Global Positioning System au service des sciences de la Terre
Warnant, René ULg

in Ciel et Terre (1998), 114(6), 166-173

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See detailPropofol reacts with peroxynitrite to form phenoxyl radicals. Demonstration by ESR
Mouithys-Mickalad, Ange ULg; Hans, Pol ULg; Deby-Dupont, Ginette et al

in Biochemical and Biophysical Research Communications (1998), 249(3), 833-837

Peroxynitrite (ONOO-), resulting from the reaction of nitric oxide with superoxide anion, is a powerful oxidant produced in activated macrophages, during ischemia-reperfusion processes as well as in ... [more ▼]

Peroxynitrite (ONOO-), resulting from the reaction of nitric oxide with superoxide anion, is a powerful oxidant produced in activated macrophages, during ischemia-reperfusion processes as well as in neurodegenerative disorders. This study investigated the reaction of the anesthetic agent propofol (PPF) with ONOO-, using electron spin resonance (ESR) and UV-visible spectrometry. Peroxynitrite was synthetized either from acidified hydrogen peroxide and nitrite, or from sodium azide and ozone. The addition of ONOO- to PPF in alkaline solution (pH 12) allowed to detect a, short lifetime, ESR signal corresponding to a phenoxyl radical. This finding was confirmed by a UV-visible study, resulting in the appearance of 427 nm peak and the disappearance of the peak located at 239 nm. The 291 nm peak remained unchanged. The identification of the end-product of the reaction of PPF with ONOO- needs further investigations. [less ▲]

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See detailChorologie et écologie de Pycnoporus Cinnabarinus (Polyporaceae) en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes
Thoen, Daniel ULg; Fraiture, A.; Nicolas, Jacques ULg

in Belgian Journal of Botany (1998), 131(2), 260-272

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de ... [more ▼]

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de distribution. La propagation du champignon semble s'être effectuée à deux "vitesses" : par bonds, sur des distances de plusieurs dizaines de kilomètres, et de proche en proche, au départ de populations voisines. L'analyse de la fréquence et de la fréquence cumulée des récoltes montre deux grandes "vagues" successives d'expansion du champignon. La liste des arbres hôtes est établie ainsi que la fréquence relative du champignon en fonction des hôtes. Les hôtes les plus fréquents sont les bouleaux (Betula alba et Betula pendula), le hêtre (Fagus sylvatica), le sorbier des oiseleurs (Sorbus aucuparia) et les chênes (Quercus robur et Quercus petraea). Les causes de l'extension et des fluctuations des populations du champignon ne sont pas connues avec certitude. Il semble cependant que des facteurs climatiques et le fait que de plus grandes quantités de bois pourrissant soient abandonnées sur les coupes puissent être impliqués. [less ▲]

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See detailInfluence of calving season on the interactions among reproductive disorders of dairy cows.
Labernia, J.; Lopez-Gatius, F.; Santolaria, P. et al

in Animal Science Journal (1998), 67

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See detailCroissance ovocytaire et régulation stéroïdienne chez les poissons à pontes uniques et multiples: une revue.
Rinchard, J.; Kestemont, P.; Poncin, Pascal ULg

in Annales de Limnologie (1998), 34

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See detailRed blood cell precursor mass as an independent determinant of serum erythropoietin level.
Cazzola, M.; Guarnone, R.; Cerani, P. et al

in Blood (1998), 91(6), 2139-45

Serum erythropoietin (sEpo) concentration is primarily related to the rate of renal production and, under the stimulus of hypoxia, increases exponentially as hemoglobin (Hb) decreases. Additional factors ... [more ▼]

Serum erythropoietin (sEpo) concentration is primarily related to the rate of renal production and, under the stimulus of hypoxia, increases exponentially as hemoglobin (Hb) decreases. Additional factors, however, appear to influence sEpo, and in this work, we performed studies to evaluate the role of the red blood cell precursor mass. We first compared the relationship of sEpo with Hb in patients with low versus high erythroid activity. The first group included 27 patients with erythroid aplasia or hypoplasia having serum transferrin receptor (sTfR) levels < 3 mg/L (erythroid activity < 0.6 times normal), while the second one included 28 patients with beta-thalassemia intermedia having sTfR levels > 10 mg/L (erythroid activity > 2 times normal). There was no difference between the two groups with respect to Hb (8.3 +/- 1.6 v 8.0 +/- 1.3 g/dL, P > .05), but sEpo levels were notably higher in patients with low erythroid activity (1,601 +/- 1,542 v 235 +/- 143 mU/mL, P < . 001). In fact, multivariate analysis of variance (ANOVA) showed that, at any given Hb level, sEpo was higher in patients with low erythroid activity (P < .0001). Twenty patients undergoing allogeneic or autologous bone marrow transplantation (BMT) were then investigated. A marked increase in sEpo was seen in all cases at the time of marrow aplasia, disproportionately high when compared with the small decrease in Hb level. Sequential studies were also performed in five patients with iron deficiency anemia undergoing intravenous (IV) iron therapy. Within 24 to 72 hours after starting iron treatment, marked decreases in sEpo (up to one log magnitude) were found before any change in Hb level. Similar observations were made in patients with megaloblastic anemia and in a case of pure red blood cell aplasia. These findings point to an inverse relationship between red blood cell precursor mass and sEpo: at any given Hb level, the higher the number of red blood cell precursors, the lower the sEpo concentration. The most likely explanation for this is that sEpo levels are regulated not only by the rate of renal production, but also by the rate of utilization by erythroid cells. [less ▲]

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See detailEléments du diagnostic des parasitoses externes des ruminants
Lonneux, J. F.; Losson, Bertrand ULg

in Point Vétérinaire (1998), 188

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See detailPathological investigations on guillemots (Uria aalge) stranded on the Belgian coast during the winter of 1993-94
Jauniaux, Thierry ULg; Brosens, L.; Meire, P. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(14), 387-390

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were ... [more ▼]

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were observed in more than 70 per cent of the birds. There was no statistical relationship between the level of oil contamination and the severity of the lesions. Differences in bodyweight were accounted for by age, sex, emaciation, and acute haemorrhagic gastroenteropathy. The birds had a severe weight deficit but the concentrations of pollutants were below acutely toxic levels. [less ▲]

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See detailGonadal and thyroid hormones in the barbel (Barbus barbus) during and outside short reproductive cycles
Poncin, Pascal ULg; Kuhn, E. R.; Vandorpe, G. et al

in Folia Zoologica (1998), 47

Sex steroids with thyroid hormones were studied during reproduction in the European barbel Barbus barbus L., a new species for European aquaculture. In female barbel, the period between two successive ... [more ▼]

Sex steroids with thyroid hormones were studied during reproduction in the European barbel Barbus barbus L., a new species for European aquaculture. In female barbel, the period between two successive ovulations (every 12-18 days) was characterized by high estradiol-17 beta (E-2) levels (>300 pg.ml(-1)) and a sinusoidal variation of these levels. Outside the reproductive periods, the E-2 plasma concentration was significantly lower (100 pg.ml(-1)) and invariation. The spermiating males showed significantly higher testosterone (T) plasma values than non-spermiating ones. The opposite was noticed for the plasma thyroxine (T-4) concentrations: low values in males and females during reproduction, high values outside reproductive periods. Spermiating males had a higher triiodothyronine (T-3) plasma concentration compared to non-spermiating ones, whereas no significant difference is seen for the females. [less ▲]

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See detailHaematopoietic stem cell transplantation for sickle cell anaemia: the first 50 patients transplanted in Belgium.
Vermylen, C.; Cornu, G.; Ferster, Aline et al

in Bone Marrow Transplantation (1998), 22(1), 1-6

Fifty patients affected by sickle cell anaemia underwent transplantation of HLA-identical haematopoietic stem cells (bone marrow, 48; cord blood, 2). Two groups of patients were considered for ... [more ▼]

Fifty patients affected by sickle cell anaemia underwent transplantation of HLA-identical haematopoietic stem cells (bone marrow, 48; cord blood, 2). Two groups of patients were considered for transplantation. Group 1 included 36 permanent residents of a European country who, retrospectively, met the inclusion criteria accepted at a consensus conference held in Seattle in 1990, wherein children were selected because they already had evidence of a morbid course. Group 2 included 14 patients who were transplanted earlier, had not received more than three blood transfusions and were transplanted because they had decided to return to their country of origin. Kaplan-Meier estimates of overall survival, event-free survival and disease-free survival at 11 years of the whole grafted population are 93, 82 and 85%, respectively. In group 1, overall survival, EFS and DFS were 88, 76 and 80% and in group 2, 100, 93 and 93%, respectively. Clinical manifestations of the disease, as well as disease associated haemolytic anaemia, disappeared in all successfully treated patients. Recovery of spleen function was present in seven out of 10 evaluated patients. Adverse events (death, absence of engraftment, mixed chimerism and relapse) occurred more frequently in group 1 than in group 2 (25% vs 7%, P< 0.001). Acute graft-versus-host disease (GVHD) was present in 20 patients (grade I or II, 19; grade III, 1), chronic GVHD in 10 (limited, 7; extensive, 3). One patient developed an acute myeloid leukaemia. Gonadal dysfunction was present in all patients (six boys and eight girls) transplanted close to or after puberty, although transient in one adolescent girl. [less ▲]

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See detailAdolescence...Quand tu nous tiens
Stassart, Martine ULg

in Mélanges Cliniques (1998)

In view of studying the psychodynamic assessment of the vocational attitude of the 18 years old adolescent, according to his self-representation as resolute, undecided, or quite determined, we ... [more ▼]

In view of studying the psychodynamic assessment of the vocational attitude of the 18 years old adolescent, according to his self-representation as resolute, undecided, or quite determined, we investigated the psychical process of a sample of 30 subjects through a set of cognitive tests (F.I.D., Locus of Control) and projective tests (TAT, Rorschach, Szondi) with regard to cognitive perceptive aspects and identification patterns. The sample was consisting of 30 final year students subdivided into three categories, namely resolute, undecided, quite-determined, each group including five females and five males. The 30 subjects were again contacted four years latter and retested (except one). At first, we interpreted, case by case, for each group, the cognitive tests, the T.A.T., the Rorschach, and the Szondi in order. In a second time, we performed a statistical analysis of all quantifiable data. In the frame of this presentation, we will focus on findings of projective techniques. In the light of the projective tests, the characters "resolute", "undecided", and "quite-determined", taken as symptoms, seem to be supported by specific intra-psychical dynamics. So far it must be pointed out that females intrapsychical dynamic is always better than male's one. [less ▲]

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See detailImagination et imaginaire
Jamin, Jérôme ULg

in Cahiers Internationaux de Symbolisme (1998), 89

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See detailAtmospheric CO2 consumption by continental erosion: present-day controls and implications for the last glacial maximum
Ludwig, Wolfgang; Amiotte-Suchet, Philippe; Munhoven, Guy ULg et al

in Global and Planetary Change (1998), 16-17

The export of carbon from land to sea by rivers represents a major link in the global carbon cycle, For all principal carbon forms, the main factors that control the present-day fluxes at the global scale ... [more ▼]

The export of carbon from land to sea by rivers represents a major link in the global carbon cycle, For all principal carbon forms, the main factors that control the present-day fluxes at the global scale have been determined in order to establish global budgets and to predict regional fluxes. Dissolved organic carbon fluxes are mainly related to drainage intensity, basin slope, and the amount of carbon stored in soils. Particulate organic carbon fluxes are calculated as a function of sediment yields and of drainage intensity. The consumption of atmospheric/soil CO2 by chemical rock weathering depends mainly on the rock type and on the drainage intensity. Our empirical models yield a total of 0.721 Gt of carbon (Gt C) that is exported from the continents to the oceans each year. From this figure, 0.096 Gt C come from carbonate mineral dissolution and the remaining 0.625 Gt C stem from the atmosphere (F-CO2). Of this atmospheric carbon, 33% is discharged as dissolved organic carbon, 30% as particulate organic carbon, and 37% as bicarbonate ions. Predicted inorganic carbon fluxes were further compared with observed fluxes for a set of 35 major world rivers, and possible additional climatic effects on the consumption of atmospheric CO2 by rock weathering were investigated in these river basins. Finally, we discuss the implications of our results for the river carbon fluxes and the role of continental erosion in the global carbon cycle during the last glacial maximum. [less ▲]

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See detailSuccessful Bridge to Transplantation with Pierce Donachy (Thoratec) Ventricular Assist Device
DEFRAIGNE, Jean ULg; DETRY, Olivier ULg; Demoulin, J.C. et al

in Acta Chirurgica Belgica (1998), 98(2), 90-4

Biventricular assistance with the Thoratec ventricular assist device was performed in a 48-year-old man waiting heart transplantation since 6 months. Indication for circulatory support was considered ... [more ▼]

Biventricular assistance with the Thoratec ventricular assist device was performed in a 48-year-old man waiting heart transplantation since 6 months. Indication for circulatory support was considered because of the development of progressive irreversible right heart failure with deterioration of the hepatic and renal functions. Orthotopic heart transplantation was performed after 13 days of circulatory support. No complications occurred during the assistance and in the posttransplant period. The patient was discharged on day 21 after transplantation. Five months after transplantation he is well and alive. [less ▲]

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See detailSample size for collecting seeds in germplasm conservation: the case of the Lima bean (Phaseolus lunatus L.)
Bi, Irié Zoro; Maquet, A.; Degreef, J. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1998), 97(1-2),

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See detailLes annonces de librairie dans l'Elite des nouvelles (1717-1721)
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1998), 282

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See detailReaction of N-benzylideneanilines with methyl 3-aminocrotonate catalyzed by inorganic solids
Balogh, Maria; Delaude, Lionel ULg; Hermecz, Istvan

in Heterocyclic Communications (1998), 4(5), 403-410

N-benzylideneanilines 1 react with methyl 3-aminocrotonate 2 in the presence of solid acidic catalysts (K10 montmorillonite or ZF520 zeolite) to give dimethyl 4-(substituted)phenyl-2,6dimethyl-1,4 ... [more ▼]

N-benzylideneanilines 1 react with methyl 3-aminocrotonate 2 in the presence of solid acidic catalysts (K10 montmorillonite or ZF520 zeolite) to give dimethyl 4-(substituted)phenyl-2,6dimethyl-1,4-dihydropyridine-3,5-dicarboxylates 3 as major products. Methyl 2-(methoxycarbonylmethylene)-6-methyl-4-(substituted)phenyl-1,2,3,4-tetr ahydro-5-pyridinecarboxylates 4 and methyl 4-(methoxycarbonylmethyl)-2-methyl-6- (substituted)phenyl-3-pyridinecarboxylates 5 were isolated as minor products. [less ▲]

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See detailA formal definition of time in LOTOS
Léonard, Luc; Leduc, Guy ULg

in Formal Aspects of Computing (1998), 10(3), 248-266

Enhanced Timed-LOTOS, denoted ET-LOTOS, is an extension of LOTOS that allows the modelling of real-time behaviours. It covers all the aspects of full LOTOS, including data types, it supports both a dense ... [more ▼]

Enhanced Timed-LOTOS, denoted ET-LOTOS, is an extension of LOTOS that allows the modelling of real-time behaviours. It covers all the aspects of full LOTOS, including data types, it supports both a dense and a discrete time domain and can manipulate time values as any other data values. A tutorial on ET-LOTOS, showing many application examples, has already been published elsewhere. The present paper adds to it by providing an in-depth presentation of its theoretical aspects. The complete semantics is given and explained, and its proper-ties are studied. In particular, we prove that the semantics is consistent and that strong bisimulation is a congruence. This requires to deal carefully with the presence of negative premises in the operational semantics, which are necessary to express urgency. ET-LOTOS is also shown to be a conservative extension of LOTOS for guarded processes, and is the basis of the timed extension of LOTOS currently developed by ISO. To our knowledge, this is the first in-depth study of a language that combines data types and real-time behaviours. [less ▲]

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See detailCurrent Status of fluoride salts to treat postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Paul, I.; Gosset, Christiane ULg

in Current Opinion in Orthopaedics (1998), 9(V), 7-10

Fluoride has been used over the past 25 years as a potential treatment of established osteoporosis. Notwithstanding a consensus over its ability to stimulate bone formation, discrepant results were ... [more ▼]

Fluoride has been used over the past 25 years as a potential treatment of established osteoporosis. Notwithstanding a consensus over its ability to stimulate bone formation, discrepant results were published relating to its antifracture efficacy. Differences in the published results are likely to be linked to therapeutic regimens, fluoride formulation, and the nature of the treated populations. A critical review of the published data evaluating the antifracture efficacy of fluoride leads to the conclusion that this substance should be mainly used in postmenopausal women with low bone mineral density without prevalent fracture, that low-dose fluoride for a prolonged period should be preferred to high doses for short-term treatment, and that gastroresistant preparations are likely to be better tolerated than fluoride. [less ▲]

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See detailApplication de l'échographie à la ponction ovarienne
Hanzen, Christian ULg; Goffin, L.

in Annales de Médecine Vétérinaire (1998), 142

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See detailClose projected QSO-Galaxy associations: are they real?
Claeskens, Jean-François ULg; Surdej, Jean ULg

in Astronomy and Astrophysics (1998), 335

The present status of close projected associations between high redshift quasars and foreground galaxies is reviewed in the framework of gravitational lensing, adopting both an observational and a ... [more ▼]

The present status of close projected associations between high redshift quasars and foreground galaxies is reviewed in the framework of gravitational lensing, adopting both an observational and a theoretical approach. The Non Singular Isothermal Spherical lens model (Hinshaw & Krauss 1987) is used. We confirm that a stronger overdensity q of bright galaxies is expected at small projected angular separations (<= 3arcsec ) from high redshift and bright (thus highly luminous) quasars (HLQs). The effects of a non singular galactic core radius and/or microlensing only slightly enhance this expected overdensity. The predictions reproduce pretty well the scarce observations which are presently available, with the exception of two rather high overdensities previously claimed in the literature (e.g. q=2.9 for theta <= 6arcsec , Webster & Hewett 1990). Uncontrolled morphological selections may affect these controversial results so that additional unbiased observations are badly needed before rejecting gravitational lensing as the mechanism to produce the observed close angular QSO-galaxy associations. We describe three new selected and bias-free samples consisting of a total of 219 different HLQs. Although an apparent overdensity is detected in two of them, these galaxy excesses are found to be statistically not significant. Firm confirmation of the reality of close projected QSO-Galaxy associations is hampered by small number statistics: the expected and observed absolute numbers of such QSO-galaxy associations are still presently found to be very small. Therefore, the corresponding error bars are quite large. We conclude that the best observational strategy to significantly detect (at 3sigma ) an overdensity of galaxies near HLQs is to observe about 1500 HLQs (M_V ~ -29) down to a limiting magnitude Rlim ~ 23. Future automated surveys may provide us with such a large and unbiased database. In conclusions, we find that the lensing-induced correlation between galaxies and HLQs at small angular separations consists of a very interesting but weak effect, much less sensitive to cosmological or astrophysical parameters than the number of multiply imaged sources expected within a sample of HLQs. Based on data collected at the European Southern Observatory, La Silla, Chile [less ▲]

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See detailPhénomènes pseudo-kartiques et karstiques dans la couverture latéritique et le substratum plutono-métamorphique du Sud du Cameroun
Vicat, Jean-Paul; Willems, Luc ULg; Pouclet, André

in Géosciences au Cameroun - collection Geocam (1998), 1

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See detailLes thérapeutiques à visée spécifiquement osseuse dans le traitement de l'ostéoporose postménopausique. Aspects pharmaco-économiques
Reginster, Jean-Yves ULg; Ben Sedrine, Wafa ULg; Gosset, Christiane ULg

in Revue Médicale de Liège (1998), 53(5), 290-293

Fairly new economic evaluations were, so far, properly conducted in the field of prevention and treatment of osteoporosis. This lack of studies is likely to be related to the pathophysiology and the ... [more ▼]

Fairly new economic evaluations were, so far, properly conducted in the field of prevention and treatment of osteoporosis. This lack of studies is likely to be related to the pathophysiology and the natural course of the disease, the small number of disease-specific instruments allowing the evaluation of quality of life changes following fractures and the frequent interaction of osteoporotic treatments with other body systems. Notwithstanding a lot of efforts have to be brought before economic evaluations in osteoporosis become a key determinant of Public Health strategies, it remains of prime interest to promote this type of research taking into account the importance of the social, human and economic burden of this disease. [less ▲]

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See detailLe cartilage articulaire peut-il se régénérer ? (2ème partie)
Henrotin, Yves ULg; Reginster, Jean-Yves ULg

in Le Généraliste (1998), 415

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See detailInducible class C beta-lactamases produced by psychrophilic bacteria
Pierrard, Annick ULg; Ledent, P.; Docquier, J. D. et al

in FEMS Microbiology Letters (1998), 161

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See detailIdentification of a fossil wood specimen in the Red Sandstone Group of Southwestern Tanzania: stratigraphical and tectonic implications.
Damblon, Freddy ULg; Gerrienne, Philippe ULg; Doutrelepont, Hughes et al

in Journal of African Earth Sciences (1998), 26

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See detailToxiques et analyses biologiques en toxicologie hospitalière
Capolaghi, B.; Charlier, Corinne ULg; Feuillu, A. et al

in Toxicorama (1998), X

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See detailEin Devon/Karbon-Grenzprofil im Untergrund Der Niederrheinischen Bucht Bei Krefeld.
Bless, M.J.M.; Brauckmann, C.; Conil, R. et al

in Fortschr. Geol. Rheinld. U. Westf (1998), 37

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See detailEffect of a set stabled environmental control on pulmonary function and airway reactivity of COPD affected horses
Vandenput, Sandrina ULg; Votion, Dominique ULg; Duvivier, D. H. et al

in Veterinary Journal (1998), 155(2), 189-195

The aim of this study was to evaluate the respiratory function of horses affected with chronic obstructive pulmonary disease (COPD) when maintained in a barn on wood shavings and fed grass silage for a ... [more ▼]

The aim of this study was to evaluate the respiratory function of horses affected with chronic obstructive pulmonary disease (COPD) when maintained in a barn on wood shavings and fed grass silage for a period of 6 weeks. The mechanics of breathing, blood gas analysis and bronchial reactivity were examined on five horses with COPD at the end of the environment-controlled period (Period B) and the results compared with values obtained after 2 months at pasture (Period A) and after the onset of clinical signs of acute crisis (Period C). The results showed that clinical and functional parameters were similar in healthy horses and in COPD horses placed on pasture or stabled and fed grass silage. Moreover, the bronchial reactivity of COPD horses at pasture was similar to the bronchial reactivity of healthy horses. COPD horses fed grass silage however presented a bronchial reactivity intermediate between those measured after Period A and Period C which suggested they would be more susceptible to develop bronchoconstriction when in contact with inhaled irritants. [less ▲]

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See detailEnvironmental control to maintain stabled COPD horses in clinical remission: effects on pulmonary function
Vandenput, Sandrina ULg; Duvivier, D. H.; Votion, Dominique ULg et al

in Equine Veterinary Journal (1998), 30(2), 93-96

The objective of this study was to test the hypothesis that stabled COPD horses can be maintained in clinical remission by replacing hay by grass silage and bedding made of wood shavings (Period B) and of ... [more ▼]

The objective of this study was to test the hypothesis that stabled COPD horses can be maintained in clinical remission by replacing hay by grass silage and bedding made of wood shavings (Period B) and of wheat straw (Period C) during 6 weeks, respectively. At the end of these different periods, the pulmonary function of the horses was assessed by mechanics of breathing and arterial blood analyses. These results were compared to those measured in clinical remission obtained after 2 months in pasture (Period A). No significant difference was observed between these 3 periods neither to values obtained for healthy horses placed during 6 weeks in a hay environment. For all that, COPD horses placed in contact with hay in the same barn developed within mean +/- s.d. 8+/-3 days clinical signs of heaves and significant alterations of pulmonary function parameters. [less ▲]

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