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See detail"Boundaries and Beyond": Memory as Quest in Janet Frame's The Carpathians
Delrez, Marc ULg

in Commonwealth : Essays and Studies (1990), 13(1), 95-105

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See detailFinancial Equilibrium and Risk Aversion in French Workers’ Cooperatives
Defourny, Jacques ULg

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (1990), 61(2-3), 331-351

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See detailGreffes de moelle osseuse: bilan au CHU de Liege.
Beguin, Yves ULg; Fassotte, Marie-France ULg; Hay, F. et al

in Revue Médicale de Liège (1990), 45(6), 268-79

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See detailLe nouveau bassin des Carènes LHCN de l'Université de Liège
Marchal, Jean ULg; Rodriguez, S.; Gulan, C.

in Journal des Ingénieurs (Le) (1990), (34), 5

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See detailTriiodothyronine inhibits transcription from the human growth hormone promoter
Morin, A.; Louette, J.; Voz, Marianne ULg et al

in Molecular & Cellular Endocrinology (1990), 71(3), 261-7

Three DNA constructs, the natural human growth hormone gene (hGH-hGH) its 500 bp promoter linked to the chloramphenicol acetyl transferase reporter gene (hGH-CAT), and its structural part linked to the ... [more ▼]

Three DNA constructs, the natural human growth hormone gene (hGH-hGH) its 500 bp promoter linked to the chloramphenicol acetyl transferase reporter gene (hGH-CAT), and its structural part linked to the herpes virus thymidine kinase promoter (TK-hGH) were introduced into rat pituitary GC cells by DEAE-dextran transfection. Transient expression was followed as a function of triiodothyronine (T3) concentration. The hGH-CAT expression was specifically inhibited by T3 following a typical dose-response curve while hGH-GH gene expression was not significantly modified. The transient expression of TK-hGH increased as a function of T3 concentration. These results indicate that T3 exerts two opposite effects on hGH gene expression. First, it down-regulates expression by acting on the promoter; second, it up-regulates expression by acting on the structural part of the gene. These action could be due to regulation of transcription and mRNA stabilization, respectively. [less ▲]

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See detailQuelques aspects structurels de la production de fraises en Belgique en 1986
Burny, Philippe ULg

in Le Fruit Belge (1990), 58(429 - 1er trimestre 1990), 1-16

Cet article traite de la production des fraises et tente à répondre à quelques questions telles que : quels sont les types de production ? Où se situent les régions productrices ? Qui pratique cette ... [more ▼]

Cet article traite de la production des fraises et tente à répondre à quelques questions telles que : quels sont les types de production ? Où se situent les régions productrices ? Qui pratique cette spéculation ? Quelle est la taille des exploitations ? [less ▲]

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See detailConséquences civiles de l'acquittement du propriétaire d'un immeuble
Kefer, Fabienne ULg

in Annales de la Faculté de Droit de l'Université de Liège (1990)

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See detailSensibilite des grains de plusieurs varietes de ble, Triticum aestivum L., vis-a-vis du charancon du ble, Sitophilus granarius (L.) (Col., Curculionidae).
Rodriguez-Cobos, C.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Mededelingen van de Faculteit Landbouwwetenschappen (Rijksuniversiteit te Gent) (1990), 55(2a),

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See detailLes banques de données en épigraphie. L’exemple de P.E.T.R.A.E.
Denooz, Joseph ULg

in Tijdschrift voor Geschiedenis (1990), 103(2), 342-354

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See detailEtude de la stabilité antigénique d'une souche non cytopathogène de virus BVD chez des animaux infectés expérimentalement de manière persistante
Mignon, Bernard ULg; Schwers, A.; Waxweiler, S. et al

in Annales de Médecine Vétérinaire (1990), 134

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See detailLe medecine ball, applications et effets
Vanderthommen, Marc ULg

in Revue de l'Education Physique (1990), 30(4), 167-175

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See detailLes bases de données en égyptologie
Winand, Jean ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1990), 26

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See detailCooperation Between Bovine Leukemia-Virus Transactivator Protein And Ha-Ras Oncogene Product In Cellular-Transformation
Willems, Luc ULg; Heremans, H.; Chen, G. et al

in Embo Journal (1990), 9(5),

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See detailHydronéphrose produite par un anévrysme géant de l'artère rénale. Traitement par autotransplantation
Creemers, Etienne ULg; VAN DAMME, Hendrik ULg; Dusart, Y. et al

in Journal d'Urologie (1990), 96(1), 40-4

The authors report a case of hydronephrosis secondary to a giant aneurysm of the left renal artery, displacing the pyeloureteral junction. Decompression was obtained via "ex situ" reconstructive arterial ... [more ▼]

The authors report a case of hydronephrosis secondary to a giant aneurysm of the left renal artery, displacing the pyeloureteral junction. Decompression was obtained via "ex situ" reconstructive arterial surgery, followed by renal autotransplantation without division of the ureter. [less ▲]

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See detailLe mulot de îles d'Hyères: un cas de gigantisme insulaire
Libois, Roland ULg

in Vie et milieu (1990), 40(2-3), 217-222

A sample of woodmice caught on the Porquerolles island, 2 km off the French coast (Var), has been studied and compared with other ones collected in Corsica and on the mainland. Some yellow-necked wood mie ... [more ▼]

A sample of woodmice caught on the Porquerolles island, 2 km off the French coast (Var), has been studied and compared with other ones collected in Corsica and on the mainland. Some yellow-necked wood mie (A. flavicollis) from Belgium are also included in the comparisons. Sixteen biometrical characters were measured on each wood mouse skull and statistical analyses performed: ANOVA, Student t-test and principal composent analysis. A. sylvaticus are all significantly smaller than the Porquerolles island wood mouse, nearly for all the tested variables. In fact, the size of the Porquerolles island wood mouse is quite comparable to that of the yellow-necked wood mouse. The masticatory system of the Porquerolles island wood mouse is nevertheless more developed than in the yellow-necked, making these forms clearly distinct from each other. Gigantism may be an evolutionary trend developed in response to the depletion of the predator/competitor on the island. [less ▲]

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See detailThe vacuum Ultraviolet Photoabsorption and Photoelectron Spectroscopy of Fluoroethylenes. The 1,1-, cis- and trans-C2H2FCl.
Tornow, G.; Locht, Robert ULg; Kaufel, R. et al

in Chemical Physics (1990), 146

The vacuum ultraviolet absorption spectra of the three fluorochloroethene isomers were measured in the 6-13 eV photon energy range. Additionally, the HeI and NeI photoelectron spectra were recorded. The ... [more ▼]

The vacuum ultraviolet absorption spectra of the three fluorochloroethene isomers were measured in the 6-13 eV photon energy range. Additionally, the HeI and NeI photoelectron spectra were recorded. The assignment of the various photoelectron bands is based on MNDO calculations. The vaccum UV absorption spectral features were classified in terms of Rydberg series converging to the first and second ionization energy. Besides the typical pi-pi* transition, other valence transitions were observed and tentatively assigned. In the geminal isomer spectrum the dominant Rydberg series converge to the first ionization limit at 10.02 eV, in the cis and trans isomers the most intense Rydberg transitions converge to the second ionization energy at 11.87 and 12.03 eV respectively. The first ionization energies of these latter compounds, obtained by Rydberg series analysis, are 9.89 and 9.87 eV respectively. An assignment of the vibrational structure observed in both spectra is proposed. [less ▲]

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See detailPatterns of regenerating structures in beet calli.
Carels, N.; Lepoivre, Philippe ULg; Dekegel, D. et al

in Bulletin des Recherches Agronomiques de Gembloux (1990), 25(4),

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See detailRound table on infectious bovine rhinotracheitis/infectious pustular vulvovaginitis virus infection diagnosis and control.
Ackermann, M.; Belak, S.; Bitsch, V. et al

in Veterinary Microbiology (1990), 23(1-4), 361-3

The current situation of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis infection in various European countries is reviewed. Whilst some have a high serological prevalence and use ... [more ▼]

The current situation of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis infection in various European countries is reviewed. Whilst some have a high serological prevalence and use live virus vaccines to control the disease, others have a low prevalence and two countries (Denmark and Switzerland) have national eradication schemes which are almost complete. Serology remains important for diagnosis although other tests such as delayed cutaneous hypersensitivity may have a role to play. New tests such as polymerase chain reaction may find increasing application where high sensitivity is required, such as the detection of virus in semen. [less ▲]

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See detailPOSSIBLE COMPOSITION AND CLIMATIC CHANGES DUE TO PAST INTENSE ENERGETIC PARTICLE-PRECIPITATION
Hauglustaine, Didier A.; Gérard, Jean-Claude ULg

in Annales Geophysicae [= ANGEO] (1990), 8(2), 87-96

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See detailEnquête sérologique concernant les virus IBR, CHV2, BVD, PI3, RSB et bovipestique chez les petits ruminants au Zaïre.
Jetteur, P.; Thiry, Etienne ULg; Pastoret, Paul-Pierre ULg

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (1990), 43(4), 435-7

More than 400 small ruminant sera from Zaire were screened for antibodies to IBR, CHV2, BVD, bovine and ovine PI3, BRS and rinderpest viruses. Sera from local animals were negative for BVD, PI3 and ... [more ▼]

More than 400 small ruminant sera from Zaire were screened for antibodies to IBR, CHV2, BVD, bovine and ovine PI3, BRS and rinderpest viruses. Sera from local animals were negative for BVD, PI3 and rinderpest viruses: 8% of sera were positive for IBR virus, all with higher titers to CHV2; 31% of sera were positive to BRS virus. [less ▲]

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See detailGestion des produits de dragage en provenance des voies de navigation intérieures
Marchal, Jean ULg

in Bulletin de l’Association Internationale Permanente des Congrès de Navigation [Bulletin de l'AIPCN] (1990), (supplément au n°70), 35

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See detailHomogeneous and fractal behavior of superconducting fluctuations in the electrical resistivity of granular ceramic superconductors
Ausloos, Marcel ULg; Clippe, Paulette ULg; Laurent, Christian

in Physical Review B (1990), 41(13), 9506-9509

Experimental data show that the electrical-resistivity temperature derivative diverges in a different manner in the granular ceramic superconductors YBa2Cu3O7-y and Bi1.75Pb0.25Ca2Sr2Cu3O10-y. Critical ... [more ▼]

Experimental data show that the electrical-resistivity temperature derivative diverges in a different manner in the granular ceramic superconductors YBa2Cu3O7-y and Bi1.75Pb0.25Ca2Sr2Cu3O10-y. Critical exponents are extracted and explained. The dimensionality of anomalous superconductivity fluctuations is deduced. A homogeneous case and a self-similar (fractal) behavior can occur and are found. They correspond to different values of the superconductivity s and some percolation p coherence-length ratio. The results indicate that superconductivity percolation is achieved through surface connection rather than through path connection. [less ▲]

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See detailEvidence of cardiovascular dysfunction during Pasteurella haemolytica - induced acute pneumonia in calves
Amory, Hélène ULg; Linden, Annick ULg; Desmecht, Daniel ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1990)

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See detailManipulations chromosomiques. Amélioration génétique et contrôle du sexe chez les poissons.
Castelli M.; Mélard, Charles ULg; Poncin, Pascal ULg et al

in Nouvelles de la Science et des Technologies (1990), 8(2), 61-71

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See detailFinite-elements design of a guarded heating cylinder to measure thermal properties of materials
Nicolas, Jacques ULg; Martin, Fabrice; Andre, Philippe ULg et al

in Review of Scientific Instruments (1990), 61

A device for the measurement of thermal properties of phase change materials and, in general, of medium thermal conductivity materials, is described. The measuring cell is a modified version of the ... [more ▼]

A device for the measurement of thermal properties of phase change materials and, in general, of medium thermal conductivity materials, is described. The measuring cell is a modified version of the guarded hot plate technique, here designed for about 8-cm-diam samples. A well-known difficulty arises in such a device: its limitation when the sample cross section becomes too small with respect to its thickness. A finite-element model is used to study the shape of isotherms in a thick sample (10 cm) for different configurations of the measuring device. This analysis has led to the selection of the optimum design. It shows that the instrument is able to handle samples with a diameter to thickness ratio of about 1 so far as the heat transfer coefficient remains beneath some limits (here 100 W/m2 K). The control system is also described and some typical results are presented. Review of Scientific Instruments is copyrighted by The American Institute of Physics. [less ▲]

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See detailL'Afrique du Sud hier et aujourd'hui: le contexte socioculturel
Ledent, Bénédicte ULg

in Commonwealth : Essays and Studies (1990), SP2

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See detailThe coding region for the 54-kDa protein of several pestiviruses lacks host insertions but reveals a "zinc finger-like" domain
De Moerlooze, L.; Desport, M.; Renard, A. et al

in Virology (1990), 177(2), 812-5

We sequenced cDNAs, amplified by the polymerase chain reaction (PCR), which correspond to the carboxy-terminal portion of the 54-kDa protein of various cytopathic (cp) or noncytopathic (ncp) pestiviral ... [more ▼]

We sequenced cDNAs, amplified by the polymerase chain reaction (PCR), which correspond to the carboxy-terminal portion of the 54-kDa protein of various cytopathic (cp) or noncytopathic (ncp) pestiviral strains. Except for the previously described insertions in two cp strains of the bovine viral diarrhea virus (BVDV), we did not find comparable insertions in this gene in eight pestiviral strains. The predicted amino acid sequences of this 54-kDa protein portion contain a conserved cysteine-rich stretch remarkably similar to a "zinc finger-type" binding domain found in many gene-regulatory proteins. Thus, this protein may be involved in the binding to viral RNA. [less ▲]

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See detailRelationship of serum selenium to tumor activity in acute non lymphocytic leukemia (ANLL) and chronic lymohocytic leukemia (CLL)
Beguin, Yves ULg; Bours, Vincent ULg; Delbrouck, J.-M. et al

in Metal Ions in Biology and Medicine (1990)

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See detailAnimal performance, plasma hormones and metabolites in Holstein and Belgian Blue growing-fattening bulls.
Istasse, Louis ULg; Van Eenaeme, Christian ULg; Evrard, Pierre et al

in Journal of Animal Science (1990), 68(9), 2666-73

Six Holstein (light-muscled type) and six Belgian Blue bulls (double-muscled type) were fed a finishing diet. Average daily gain was 1.36 kg for the Holstein bulls vs 1.24 kg for the Belgian Blue bulls (P ... [more ▼]

Six Holstein (light-muscled type) and six Belgian Blue bulls (double-muscled type) were fed a finishing diet. Average daily gain was 1.36 kg for the Holstein bulls vs 1.24 kg for the Belgian Blue bulls (P less than .05). Holstein bulls consumed more feed (2.3 vs 1.8 kg/100 kg body weight, P less than .001) than the Belgian Blue bulls. The dressing percentage (55.4 vs 65.8%, P less than .001) and the proportion of muscle (56.1 vs 71.3%, P less than .001) in the carcass were less, whereas the proportions of adipose tissue (28.3 vs 15.4%, P less than .001) and bone (15.7 vs 13.4%, P less than .05) were higher in the Holstein bulls. Plasma creatinine determined in samples obtained once a week was lower (11.0 vs 20.3 mg/liter, P less than .001) in the Holstein bulls. In contrast, Holstein bulls tended to produce more triiodothyronine (2.3 vs 1.8 nM, P less than .10), tetraiodothyronine (71.9 vs 54.7 nM, P less than .10) and insulin-like growth factor I (IGF-I; 340 vs 205 ng/ml, P less than .20) than the Belgian Blue bulls. Growth hormone, insulin, IGF-I and testosterone were measured at 20-min intervals during two 24-h periods. In wk 6, Holstein bulls tended to produce more growth hormone than the Belgian Blues, as indicated by higher total peak area (3,185 vs 2,431 ng), peak amplitude (34.1 vs 22.6 ng/ml, P less than .10) and baseline (4.6 vs 3.3 ng/ml, P less than .20). In wk 27, the trends were opposite.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailConstraints on the standard model and two Higgs models from $B$ and $K$ physics
Cocolicchio, Decio; Cudell, Jean-René ULg

in Physics Letters B (1990), B245

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See detailQuelques spécimens de Gosslingia breconensis (Hear) Hear, 1927 dans le Dévonien inférieur...
Gerrienne, Philippe ULg

in Annales de la Société Géologique de Belgique (1990), 113

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See detailSerum immunoreactive erythropoietin during pregnancy and in the early postpartum.
Beguin, Yves ULg; Lipscei, G.; Oris, Renée ULg et al

in British Journal of Haematology (1990), 76(4), 545-9

We studied 209 women during normal pregnancy, at delivery, or in the early postpartum, to determine whether erythropoietin (EPO) response was appropriate for the degree of anaemia. Serum immunoreactive ... [more ▼]

We studied 209 women during normal pregnancy, at delivery, or in the early postpartum, to determine whether erythropoietin (EPO) response was appropriate for the degree of anaemia. Serum immunoreactive EPO was measured in 74 nonpregnant women, including 33 normal subjects (16.4 +/- 4.1 mU/ml) and 41 women with hypoplastic, haemolytic, dyserythropoietic, or iron-deficient anaemia. An inverse linear relationship (R = -0.88, P less than 0.0001) between log(EPO) and Hct was observed. Predicted EPO values were derived for each Hct and an O/P ratio of observed/predicted log(EPO) was calculated for each sample (1.00 +/- 0.10, range 0.80-1.20). Serum EPO levels (mU/ml) were significantly higher during pregnancy (30 +/- 16, n = 142), at delivery (31 +/- 16, n = 41), and on day 7 postpartum (37 +/- 35, n = 26) than in normal women (P less than 0.001). EPO levels increased steadily from 18 +/- 6 mU/ml in the first, to 26 +/- 14 mU/ml in the second, and to 35 +/- 18 mU/ml in the third trimester (P less than 0.0001). The O/P ratio was normal on day 7 postpartum (1.01 +/- 0.16), at delivery (1.03 +/- 0.16), and in the third trimester (0.96 +/- 0.15), but was significantly reduced in the first two trimesters (0.88 +/- 0.15, P less than 0.001). A significant negative correlation between log(EPO) and Hct was lacking in the first two trimesters, was present but with a reduced slope during the third trimester and at delivery, and was normal postpartum. We conclude that EPO response to anaemia is impaired in early pregnancy, recovers in late pregnancy, and normalizes rapidly in the postpartum. [less ▲]

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See detailLes mycétomes, pathologies exotiques et maladies de nos pays
Hassounah, A.; Rurangirwa, A.; Bouillenne, J. C. et al

in Revue Médicale de Liège (1990), 45

Les mycétomes sont des infections bactériennes ou mycotiques. Ils sont le plus souvent rapportés dans les pays tropicaux et subtropicaux, mais ils peuvent se rencontrer dans nos régions. Nous en ... [more ▼]

Les mycétomes sont des infections bactériennes ou mycotiques. Ils sont le plus souvent rapportés dans les pays tropicaux et subtropicaux, mais ils peuvent se rencontrer dans nos régions. Nous en rapportons cinq cas pour discuter une actualisation des moyens de diagnostic et les approches thérapeutiques. Ces affections sont caractérisées cliniquement par la présence de fistules et d'écoulements purulents contenant des grains visibles à l'oeil nu. Le diagnostic différentiel est l'actinomycose. [less ▲]

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See detailIn vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated-autoimmune syndrome
Schurmans, Stéphane ULg; Heusser, C.; Qin, H. et al

in Journal of Immunology (1990), 145

he role of IL-4 in the cellular interactions leading to the induction of CTL tolerance to H-2b alloantigens and to the development of a lupus-like autoimmune disease in BALB/c mice after neonatal ... [more ▼]

he role of IL-4 in the cellular interactions leading to the induction of CTL tolerance to H-2b alloantigens and to the development of a lupus-like autoimmune disease in BALB/c mice after neonatal injection with (C57BL/6 x BALB/c)F1 cells was investigated in vivo by using an anti-IL-4 mAb. Treatment of F1 cell-injected BALB/c mice with 15 mg of anti-IL-4 mAb was shown to interfere with tolerance induction, as assessed by the high percentages of H-2b target cell lysis and the very low or undetectable levels of B cell chimerism markers observed in these mice. Treatment with 4.5 mg of anti-IL-4 mAb interfered with tolerance induction only in one-third of F1 cell-injected BALB/c mice, but that dose induces specific modulations of the autoimmune manifestations in all mice, leading to the nearly complete prevention of the disease. In particular, the production of anti-ssDNA IgG1 and of total IgG1 and IgE antibodies was seriously affected by the treatment, as well as the proliferation and membrane Ia and K expression of F1 donor splenic cells and thymic APC. Treatment of F1 cell-injected BALB/c mice between 24 and 48 h of life with 0.5 mg of anti-IL-4 mAb did not interfere with tolerance induction, but had similar effects on the autoimmune syndrome as treatment with 4.5 mg. These results suggest that, after F1 cell injection of newborn mice, IL-4 plays an important role in the cellular interactions leading to the induction of tolerance to the corresponding alloantigens and to the development of the associated autoimmune syndrome. [less ▲]

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See detailAllogreffes et autogreffes de moelle osseuse. Indications, résultats, perspectives
Fassotte, Marie-France ULg; Beguin, Yves ULg; Andrien, F. et al

in Médecine et Hygiène (1990), 48

This paper presents a brief overview of bone marrow transplantation including pretransplant considerations, the transplant procedure, early and delayed complications and the relative roles of chemotherapy ... [more ▼]

This paper presents a brief overview of bone marrow transplantation including pretransplant considerations, the transplant procedure, early and delayed complications and the relative roles of chemotherapy versus transplantation in leukemias and lymphomias. [less ▲]

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See detailComparison of the adrenocortical response to both pharmacological and physiological stresses in sport horses
Linden, Annick ULg; Art, Tatiana ULg; Amory, Hélène ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1990), 37(8), 601-604

Seven sport horses were investigated to compare physiological and pharmacological stresses on the plasma glucocorticosteroid levels. <br />Venous blond was sampled and analysed for cortisol concentrations ... [more ▼]

Seven sport horses were investigated to compare physiological and pharmacological stresses on the plasma glucocorticosteroid levels. <br />Venous blond was sampled and analysed for cortisol concentrations before and after each type of stress. The physiological stress was induced by the completion of a cross-country and the phar¬macological one, by an intravenous ACTH administration (200 µg) in the came horses, one week after the course. <br />Both exercise and ACTH injection induced a highly significant cortisol increase of 79 ± 0.10 %, and 160 ± 0.18 %, respectively. The relative plasma cortisol increases due to exercise on the nue hand, and due to ACTH administration on the other hand, were correlated with a coefficient of 0.82. It was concluded that the plasma cortisol increase induced by a standardised pharmacological stress could be used in order to predict the exercise-induced stress response. [less ▲]

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See detailRôle du volume globulaire moyen dans le diagnostic de l'anémie
Triffaux, H.; Fillet, Georges ULg

in Actualité Médicale Belge (1990), 275

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See detailThe supergiant Bep star CD - 42 11721 deg and its surrounding nebula
Hutsemekers, Damien ULg; van Drom, E.

in Astronomy and Astrophysics (1990), 238

New spectroscopic and direct imagery observations of the supergiant Bep star CD - 42 11721 deg and its surrounding nebula are reported. The spectrum of the star essentially consists of Balmer and Fe II ... [more ▼]

New spectroscopic and direct imagery observations of the supergiant Bep star CD - 42 11721 deg and its surrounding nebula are reported. The spectrum of the star essentially consists of Balmer and Fe II emission lines, He I emission lines are also observed, confirming the presence of spectral variations on long timescales. The clumpy arc-shaped structure of the nebula as well as the presence of motions relative to the central star highly suggest that it has been influenced by a variable mass-loss. The nebula shows both the reflection and emission characteristics. Its spectrum displays the red forbidden N II and S II lines while no oxygen forbidden lines can be detected. Its tempting to interpret this situation by a N/O overabundance which may indicate the presence of processed material in the nebula and thus confirm the evolved nature of the star. [less ▲]

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See detailLa carte postale de Jacques Derrida à Marcel Thiry
Steinmetz, Rudy ULg

in Textyles : Revue des Lettres Belges de Langue Française (1990)

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See detailPulsatile glucagon has greater hyperglycaemic, lipolytic and ketogenic effects than continuous hormone delivery in man: effect of age.
Paolisso, G.; Buonocore, S.; Gentile, S. et al

in Diabetologia (1990), 33(5), 272-7

The present study aimed at investigating the hyperglycaemic, lipolytic and ketogenic effects of small doses of glucagon delivered continuously or in a pulsatile manner. The study was performed in eight ... [more ▼]

The present study aimed at investigating the hyperglycaemic, lipolytic and ketogenic effects of small doses of glucagon delivered continuously or in a pulsatile manner. The study was performed in eight healthy young volunteers (24.2 +/- 1.2 years) and in eight healthy aged subjects (69.4 +/- 2.0 years). In all the subjects, endogenous pancreatic hormone secretion was inhibited by somatostatin and only glucagon was replaced. Consequently, the effects of pulsatile and continuous glucagon delivery were studied in conditions of progressive somatostatin-induced insulin deficiency. In both the young and the aged subjects, pulsatile glucagon delivery resulted in increases in plasma glucose, non-esterified fatty acid, glycerol and beta-hydroxybutyrate levels greater than those observed when the same amount of glucagon was delivered in a continuous manner. The net increases in plasma glucose, glycerol and non-esterified fatty acid levels were similar between the young and the aged subjects when glucagon was infused continuously; in contrast, the rise in plasma beta-hydroxybutyrate in the aged was only about half that observed in the young subjects. Surprisingly, when glucagon was infused in a pulsatile manner, the rises in plasma glycerol, non-esterified fatty acid and beta-hydroxybutyrate levels were all significantly smaller in the aged subjects, while no significant differences were observed in the blood glucose responses. We conclude that, in the presence of somatostatin-induced insulin deficiency, pulsatile glucagon exerts greater effects on blood glucose, plasma non-esterified fatty acid, glycerol and beta-hydroxybutyrate levels than its continuous delivery. In the elderly, the lipolytic and ketogenic, but not the hyperglycaemic, responses to pulsatile glucagon are significantly reduced. [less ▲]

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See detailEnergy levels and oscillator strengths for gallium-like ions (Br V- In XIX)
Biémont, E; Quinet, Pascal ULg

in Journal of Quantitative Spectroscopy & Radiative Transfer (1990), 44

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See detailLes lombalgies: diagnostic différentiel
Reginster, Jean-Yves ULg; Lecart, MP

in Reuma (1990), 35

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See detailBacterial production and purification of recombinant human prolactin
Paris, N.; Rentier-Delrue, Françoise ULg; Defontaine, A. et al

in Biotechnology & Applied Biochemistry (1990), 12(4), 436-49

Escherichia coli cells transformed with a recombinant plasmid (pT7L) containing the coding sequence of human prolactin (hPrl) expressed a new protein. This protein, comigrating with human Prl on sodium ... [more ▼]

Escherichia coli cells transformed with a recombinant plasmid (pT7L) containing the coding sequence of human prolactin (hPrl) expressed a new protein. This protein, comigrating with human Prl on sodium dodecyl sulfate (SDS)-polyacrylamide gels, represented 50% of the total bacterial extract. Immunoprecipitation of [35S]methionine-labeled bacterial lysate with a rabbit antiserum to hPrl followed by SDS-polyacrylamide gel electrophoresis (PAGE) analysis showed that the major component had a Mr identical to that of standard hPrl. The majority of the recombinant hPrl (r-hPrl) accumulated in inclusion bodies. Analysis of these inclusion bodies by SDS-PAGE under nonreducing conditions showed that they are composed mostly of fully reduced monomers. Solubilization of the inclusion bodies and protein denaturation were performed in 8 M urea. Refolding during the renaturation procedure was confirmed by SDS-PAGE under nonreducing conditions. r-hPrl was further purified by gel permeation chromatography on a fast protein liquid chromatography column. More than 95% of the molecules were recovered as oxidized monomeric forms. The refolded molecule was tested for its bioactivity in the Nb2 lymphoma mitogenic assay. The dose-response curves obtained with either r-hPrl or pituitary-derived hPrl showed a complete parallelism. Furthermore, Nb2 cell proliferation was completely blocked by addition of hPrl antiserum to both preparations. Recombinant hPrl is identical to natural hPrl except for an additional methionine group at the amino terminal end. [less ▲]

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See detailRegulation of Ion Uptake in Membrane Vesicles from Rat Brain by Thiamine Compounds
Bettendorff, Lucien ULg; Wins, Pierre; Schoffeniels, Ernest

in Biochemical and Biophysical Research Communications (1990), 171(3), 1137-1144

We examined the effects of thiamine derivatives on ion uptake in rat brain membrane vesicles. Thiamine triphosphate (1 mM) and pyrithiamine (0.1 mM) increase chloride uptake. Preincubation of crude ... [more ▼]

We examined the effects of thiamine derivatives on ion uptake in rat brain membrane vesicles. Thiamine triphosphate (1 mM) and pyrithiamine (0.1 mM) increase chloride uptake. Preincubation of crude homogenate with thiamine or pyrithiamine increases chloride uptake while oxythiamine has the reverse effect. Thiamine and oxythiamine also affect 22Na+ and 86Rb+ uptake in the same way as for 36Cl- but to a lesser extent. Thiamine-dependent 36Cl- uptake is activated by sodium bicarbonate (10 mM) and partially inhibited by bumetanide (0.1 mM) and 2,4-dinitrophenol (0.1 mM). Preincubation with thiamine increases the thiamine triphosphate content of the vesicles. The hypothesis that TTP is the activator of a particular chloride uptake mechanism is discussed. [less ▲]

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See detailRéflexions sur les vases métalliques des tributaires Keftiou
Laboury, Dimitri ULg

in Aegeum - Annales d'Archéologie égéenne de l'Université de Liège (1990), 6

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See detailPhysiologie de la secrétion gastrique acide: données récentes
Delwaide, Jean ULg; Belaiche, Jacques ULg

in Revue Médicale de Liège (1990), 45(1), 22-28

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See detailModelling of the underground coal gasification process at Thulin on the basis of thermodynamical equilibria and isotopic measurements
Dufaux, Anne; Gaveau, Bénédicte; Létolle, René et al

in Fuel (1990), 69

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See detailDirect and neurally mediated effects of halothane on pulmonary resistance in vivo.
Warner, David O; Vettermann, Jörg; Brichant, Jean-François ULg et al

in Anesthesiology (1990), 72(6), 1057-63

It has been suggested that halothane inhibits contraction of airway smooth muscle in vivo mainly by reducing reflex activity in nerves innervating the muscle with only minimal direct effects on the muscle ... [more ▼]

It has been suggested that halothane inhibits contraction of airway smooth muscle in vivo mainly by reducing reflex activity in nerves innervating the muscle with only minimal direct effects on the muscle itself. To examine possible mechanisms of action of halothane at clinically relevant concentrations the authors studied the effect of halothane on increases in pulmonary resistance (RL) produced by either vagus nerve stimulation (VNS, which caused neurally mediated constriction) or the inhalation of nebulized acetylcholine (ACh, which directly stimulated the smooth muscle cell) in nine mongrel dogs. The frequency of bilateral VNS and the dose of nebulized ACh were adjusted to produce approximately equal increases in RL. Halothane reduced the response to both types of stimulation in a dose-dependent fashion. At halothane concentrations greater than or equal to 0.4 MAC, the VNS response was significantly less than the ACh response. When tetrodotoxin was given to block neural activity, the ACh response was unchanged, confirming that neural activation did not contribute significantly to smooth muscle contraction in response to ACh. The authors conclude that in addition to neurally mediated effects, halothane at clinically used concentrations has significant direct effects on airway smooth muscle stimulated by ACh. The relative importance of each factor in vivo should depend on the stimulus that causes contraction of airway smooth muscle. [less ▲]

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See detailRegulatory elements controlling pituitary-specific expression of the human prolactin gene
Peers, Bernard ULg; Voz, Marianne ULg; Monget, Philippe et al

in Molecular & Cellular Biology (1990), 10(9), 4690-700

We have performed transfection and DNase I footprinting experiments to investigate pituitary-specific expression of the human prolactin (hPRL) gene. When fused to the chloramphenicol acetyltransferase ... [more ▼]

We have performed transfection and DNase I footprinting experiments to investigate pituitary-specific expression of the human prolactin (hPRL) gene. When fused to the chloramphenicol acetyltransferase (CAT) reporter gene, 5,000 base pairs of the 5'-flanking sequences of the hPRL gene were able to drive high cat gene expression in prolactin-expressing GH3B6 cells specifically. Deletion analysis indicated that this pituitary-specific expression was controlled by three main positive regulatory regions. The first was located just upstream from the TATA box between coordinates -40 and -250 (proximal region). We have previously shown that three motifs of this region bind the pituitary-specific Pit-1 factor. The second positive region was located in the vicinity of coordinates -1300 to -1750 (distal region). DNase I footprinting assays revealed that eight DNA motifs of this distal region bound protein Pit-1 and that two other motifs were recognized by ubiquitous factors, one of which seems to belong to the AP-1 (jun) family. The third positive region was located further upstream, between -3500 and -5000 (superdistal region). This region appears to enhance transcription only in the presence of the distal region. [less ▲]

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See detailHealth effects of environmental exposure to cadmium: objectives, design and organization of the Cadmibel
Lauwerys, Robert; Amery, Antoon; Bernard, Alfred et al

in Environmental Health Perspectives (1990), 87

Cadmium is a cumulative environmental pollutant. For the general population mainly exposed by the oral route and through tobacco smoke inhalation, the kidney is the critical organ. Belgium is the ... [more ▼]

Cadmium is a cumulative environmental pollutant. For the general population mainly exposed by the oral route and through tobacco smoke inhalation, the kidney is the critical organ. Belgium is the principal producer of cadmium in Europe, and certain areas of the country are polluted by cadmium mainly because of past emissions from nonferrous industries. Preliminary studies carried out in one polluted area have suggested that environmental pollution might lead to an increased uptake of cadmium by the human body and possibly to health effects. Thus, a large-scale morbidity study has been initiated to assess the validity of this hypothesis. The present paper describes the protocol of this study. Its main objectives are to determine to what extent environmental exposure to cadmium resulting from industrial emissions may lead to accumulation of the metal in the human organism; to establish whether or not environmental exposure may induce renal changes and/or influence blood pressure; and to assess the acceptable internal dose of cadmium for the genral population. The study design takes advantage of the fact that biological indicators of exposure, body burden, and early nephrotoxic effects of cadmium ar available, which increase the likelihood of detecting a cause-effect relationship. [less ▲]

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See detailThe porphyritic facies and the endoskarns of the Traversella monzodiorite: Implications for the evolution of the main intrusion (Ivrea, Italy)
Vander Auwera, Jacqueline ULg

in Schweizerische Mineralogische und Petrographische Mitteilungen = Bulletin Suisse de Minéralogie et Pétrographie (1990), 70

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See detailType Iv and Interstitial Collagenolytic Activities in Normal and Malignant Trophoblast Cells Are Specifically Regulated by the Extracellular Matrix
Emonard, H.; Christiane, Y.; Smet, M. et al

in Invasion & Metastasis (1990), 10(3), 170-7

Type IV and interstitial collagenolytic activities were compared in human malignant and normal trophoblast cells cultured on plastic, in presence or absence of laminin in solution, on matrigel (a gel of ... [more ▼]

Type IV and interstitial collagenolytic activities were compared in human malignant and normal trophoblast cells cultured on plastic, in presence or absence of laminin in solution, on matrigel (a gel of basement membrane components) and on type I collagen gel. Laminin highly stimulated the type IV collagenolytic activity but not the interstitial collagenolytic activity, in malignant trophoblast cells. This glycoprotein had no effect on the interstitial collagenolytic activity and doubled the type IV collagenolytic activity in normal trophoblast cells. Thus malignant trophoblast cells produce preferentially the enzyme able to degrade basement membrane when in contact with laminin, and the enzyme able to degrade interstitial collagen fibers when cultured on type I collagen. On the contrary, type I collagen gel and matrigel equally increased both type IV and interstitial collagenolytic activities by normal trophoblast cells. Interactions of tumor trophoblast or normal trophoblast cells with the extracellular matrix result thus in distinct stimulations of collagenolytic activities. Increased production of type IV collagenolytic activity upon exposure to laminin appears to be specific of the metastatic phenotype. [less ▲]

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See detailEvolution des concentrations plasmatiques de testostérone et d'insulin-like growth factor I en période péripubertaire chez le bovin cathétérisé au niveau hépatique.
Renaville, Robert ULg; Berkans, X.; Portetelle, Daniel ULg et al

in Annales de Recherches Vétérinaires = Annals of Veterinary Research (1990), 21

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See detail195au Biokinetics and Dosimetry
Brihaye, C.; Guillaume, Marcel

in European Journal of Nuclear Medicine (1990), 16(4-6), 369-71

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See detailVilles du monde : similitudes et diversités
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (1990), 26

The cities of the world may look in many different ways but they also present many similarities. The aim of this article is to study these two lendancies and so, to introduce this issue dedicated to ... [more ▼]

The cities of the world may look in many different ways but they also present many similarities. The aim of this article is to study these two lendancies and so, to introduce this issue dedicated to "Cities of the World". In this first part, the principal common features in cities located sometimes at the antipodes are analized and a tentative summary concerning three typical aspects of the urban environment is introduced : the differences in the urban landscape, the multitude of functions, the crisis and the problems. In the second part, a comparison is made between five big types of cities (Western Europe, North America, industrialized socialist countries, developing countries and muslim areas). It is based on seven criterios : growth structures, the historical and cultural heritage, spatial structures and plans, transportation means, functions, population and housing, and general tendancies of town planning. [less ▲]

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See detailThe Rock of Empire: The Image of the Stone in Randolph Stow's To the Islands
Delrez, Marc ULg

in BELL. Belgian Essays on Language and Literature (1990)

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See detailLa forêt et les forestiers: réalités, nouvelles approches et défis.
Rondeux, Jacques ULg

in Annales de Gembloux (1990), 96(1), 1-19

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See detailWhither dynamic state estimation ?
Rousseaux, Patricia ULg; Van Cutsem, Thierry ULg; Dy Liacco, Tom

in International Journal of Electrical Power & Energy Systems (1990), 12(2), 104-116

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See detailPhase formation during aging of Zn-12% Al and Zn-27% Al alloys at 100°C.
Terziev, L.; Rachev, P.; Lecomte-Beckers, Jacqueline ULg et al

in Zeitschrift für Metallkunde (1990), 81[6]

The phase formation during ageing of ZrH2 wt% AI and Zna27 wt.% AI alloys at 100 O has been studied by means of transmission electron microscopy and electron diffraction. No formation of ellipsoidal ... [more ▼]

The phase formation during ageing of ZrH2 wt% AI and Zna27 wt.% AI alloys at 100 O has been studied by means of transmission electron microscopy and electron diffraction. No formation of ellipsoidal precipitates of GP 2 and c4 phase bas been observed. Precipitation of hexagonal phases occurs generally on account of the a phase. The <011> habitus plane of a new phase q has been found. The q phase has been distinguished from the metastable Qm using Moire patterns [less ▲]

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See detailIron status in runners of various running specialities
Mouton, G.; Sluse, Francis ULg; Bertrand, A. et al

in Archives Internationales de Physiologie et de Biochimie (1990), 98

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See detailEffects of design and kinematic parameters of rotary cultivators on soil structure
Destain, Marie-France ULg; Houmy, K.

in Soil & Tillage Research (1990), 17(3-4), 291-301

In comparison with drawn implements, rotary cultivators are of particular interest in final seedbed preparation. In this paper, a quantitative basis for the description of soil structure created by rotary ... [more ▼]

In comparison with drawn implements, rotary cultivators are of particular interest in final seedbed preparation. In this paper, a quantitative basis for the description of soil structure created by rotary tillers is given. Undisturbed Ap horizon samples were collected, impregnated with polyester resin, sectioned by sawing and analysed by means of image analysis. Total porosity, area and size of pores are related to the design and kinematic parameters of the rotary cultivator, arising from an analysis based upon the location of instant centres of velocity. It is shown that using a rotary cultivator with a higher ratio of peripheral to forward velocity leads to a smaller total mean porosity which is more homogeneous. [less ▲]

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See detailA disorder of axonal development, necrotizing myopathy, cardiomyopathy and cataracts: A new familial disorder
Lyon, Gilles; Arita, Frenando; Le Galloudec, Eric et al

in Annals of Neurology (1990), 27

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See detailEtude comparative de modèles des plus proches voisins ajustés à des essais à blanc
Goumari, A.; Claustriaux, Jean-Jacques ULg

in Biométrie-Praximétrie (1990), (30), 49-64

Une série de modèles des plus proches voisins sont ajustés à des essais à blanc, en vue de déterminer celui qui permet d'expliquer le mieux la performance d'une parcelle en fonction de celle de ses ... [more ▼]

Une série de modèles des plus proches voisins sont ajustés à des essais à blanc, en vue de déterminer celui qui permet d'expliquer le mieux la performance d'une parcelle en fonction de celle de ses voisins. Sur la base de la réduction de la variation résiduelle et de l'analyse de l'autocorrélation spatiale des rendements observés et estimés, trois modèles ont été sélectionnés. [less ▲]

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See detailCalcitonine, ménopause et ostéoporose
Reginster, Jean-Yves ULg

in Cycléos (1990), 5

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See detailFronts tidaux sur le Plateau Continental Nord Ouest Européen
Djenidi, Salim ULg

in Bulletin de la Société Royale des Sciences de Liège (1990), 59(2), 205-216

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See detailCerebral Glucose Utilization During Sleep in Landau-Kleffner Syndrome: A Pet Study
Maquet, Pierre ULg; Hirsch, E.; Dive, Dominique ULg et al

in Epilepsia (1990), 31(6, Nov-Dec), 778-83

Three right-handed male children (aged 5, 6, and 11 years) with signs, symptoms and/or history of the syndrome of acquired aphasia-epilepsy (Landau-Kleffner syndrome) were studied during drug-induced ... [more ▼]

Three right-handed male children (aged 5, 6, and 11 years) with signs, symptoms and/or history of the syndrome of acquired aphasia-epilepsy (Landau-Kleffner syndrome) were studied during drug-induced, electroencephalographically (EEG)-monitored sleep by positron-emission tomography (PET) and the [18F]fluorodeoxyglucose (FDG) method. Our data demonstrate that in Landau-Kleffner syndrome, cerebral glucose utilization is not normal during sleep. The metabolic pattern varied between the children but the metabolic disturbances always predominated over the temporal lobes. They were right-sided, left-sided, or bilateral. In the two first patients, EEG recordings showed continuous spike-and-wave discharges during sleep and a right-greater-than-left asymmetry was observed in temporal areas. In patient 1, the asymmetry was associated with a relative increase of glucose utilization of the right posterior temporal region. In patient 2, the glucose utilization was relatively decreased in the left anterotemporal and left perisylvian regions. In patient 3, the sleep EEG showed no discharge and no significant asymmetry was observed; however, glucose utilization of both temporal lobes was decreased. Lower metabolic rates in subcortical structures than in cortex were also noted in the three children. This metabolic pattern may be related to the maturation of the central nervous system (CNS). [less ▲]

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See detailLIPASES FROM PSYCHROTROPHIC ANTARCTIC BACTERIA
Feller, Georges ULg; Thiry, M.; Arpigny, J. L. et al

in FEMS Microbiology Letters (1990), 66(1-3), 239-243

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See detailLes traductions grecques de l'Enéide sur papyrus. Une contribution à l'étude du bilinguisme gréco-latin au Bas-Empire
Rochette, Bruno ULg

in Etudes Classiques (Namur, Belgium) (1990), 58

L'apparition au IV s. ap. J.C. de traductions grecques de l'Énéide dont les particularités matérielles sont les mêmes que celles des glossaires bilingues thématiques contemporains est à mettre en relation ... [more ▼]

L'apparition au IV s. ap. J.C. de traductions grecques de l'Énéide dont les particularités matérielles sont les mêmes que celles des glossaires bilingues thématiques contemporains est à mettre en relation avec la réforme linguistique de Dioclétien, qui voulait étendre l'usage du latin à toute l'administration impériale. Loin d'être toujours des stéréotypes, certaines de ces traductions attestent une connaissance assez approfondie de la langue latine. [less ▲]

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See detailLes déterminants de l'attitude face au choix vocationnel: Exploration par le Rorschach et le T.A.T.
Stassart, Martine ULg; Timsit, M.

in Bulletin de Psychologie (1990), 43(396), 773-784

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See detailDevelopment of an in vitro culture method for heart-shaped embryo in Phaseolus vulgaris.
Mergeai, Guy ULg; Baudoin, Jean-Pierre ULg

in Annual report of the Bean Improvement Cooperative (1990), 33

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See detailThe Nucleolonema of Plant and Animal Cells: A Comparison
Deltour, Roger ULg; Motte, Patrick ULg

in Biology of the Cell (1990), 68(1), 5-11

Depending on the author and the animal or plant origin of the material under study, the term "nucleolonema" is used in different contexts and thus indicates nucleolar ultrastructures that are different ... [more ▼]

Depending on the author and the animal or plant origin of the material under study, the term "nucleolonema" is used in different contexts and thus indicates nucleolar ultrastructures that are different. In this paper, we attempt to clarify this state of affairs and to propose a definition for the plant cell nucleolonema. [less ▲]

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See detailCarabides de prairies du nord du Grand-Duché de Luxembourg.
Mercatoris, Nico; Dufrêne, Marc ULg; Lebrun, Philippe

in Paiperleck (1990), 12

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See detailAssessment of respiratory diseases and therapeutic intervention by the forced oscillation technique in feedlot cattle
Gustin, Pascal ULg; Landser, F. J.; Lomba, F. et al

in Research in Veterinary Science (1990), 49(3), 319-322

The forced oscillation technique was used to study pulmonary function in bulls during naturally acquired pulmonary-gastrointestinal disease complex known as shipping fever and as it was treated with two ... [more ▼]

The forced oscillation technique was used to study pulmonary function in bulls during naturally acquired pulmonary-gastrointestinal disease complex known as shipping fever and as it was treated with two different antibiotics. Fifteen double-muscled bulls of the Belgian White and Blue breed were investigated. Clinical, serological and pulmonary function values were recorded during and after naturally occurring respiratory disease. Total respiratory resistance (Rrs) and reactance (Xrs) were measured by the forced oscillation technique. The antibiotic ceftiofur (group A, n = 10) and oxytetracycline (group B, n = 5) were given over three days. A large increase of Rrs at low frequencies with a marked negative frequency dependence, an increase of the resonant frequency, and a decrease of Xrs were recorded in the initial stage of the disease. The parameters returned to normal values seven days later. Clinical evidence of recovery was more marked in group A than in group B. These results show that moderate shipping fever induces acute small and large airway obstruction which responds to appropriate antibiotic therapy. [less ▲]

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See detailIsolation and long-term cultivation of human tonsil follicular dendritic cells.
Tsunoda, R.; Nakayama, M.; Onozaki, K. et al

in Virchows Archiv. B : Cell pathology (1990), 59(2), 95-105

Highly purified follicular dendritic cells (FDC) were isolated from human tonsils and cultivated for up to 150 days. The cell separation method employed produced pure aggregates (FDC-clusters) composed of ... [more ▼]

Highly purified follicular dendritic cells (FDC) were isolated from human tonsils and cultivated for up to 150 days. The cell separation method employed produced pure aggregates (FDC-clusters) composed of FDC and germinal center lymphoid cells, useful for the analysis of the relationship between these two cell types and of the behavior of FDC in culture. During the first few days of culture, lymphoid cells located between FDC extensions survived better than those which were free or partly covered by FDC. After 6 days, the lymphoid population degenerated and only the FDC survived. The unique antigenic pattern of FDC (positive for HLA-DR. DRC-1, CD14b, CD21, CD23, CD35) disappeared within a few days of culture. Recombinant interferon-gamma exerted a positive effect either on retaining HLA-DR expression or on the reexpression of these antigens by FDC. HLA-ABC antigens were traced until the 10th day and desmosomal junctions until the 14th day. Subsequently, FDC presented peculiar features, including oval and rhomboid shapes, one to ten nuclei, fine amoeboid extensions, stress fibers and a radical dense zone in their cytoplasm. FDC possessed actin, tubulin and vimentin, but neither desmin nor cytokeratin. After 40 days of culture, FDC enlarged and were covered with abundant membrane extensions. Even when kept as long as 150 days in vitro. FDC did not proliferate in any of the culture conditions employed. [less ▲]

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See detailConstitutive Equations of Rheological Materials : Towards a Thermodynamic Unified Approach
Dauby, Pierre ULg; Lebon, Georgy ULg

in Applied Mathematics Letters (1990), 3(4), 45-48

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See detailSynthesis, purification and initial structural characterization of octarellin, a de novo polypeptide modelled on the alpha/beta-barrel proteins
Goraj, Karine; Renard, André; Martial, Joseph ULg

in Protein Engineering (1990), 3(4), 259-66

We have attempted to construct an artificial polypeptide that folds like the eight-stranded parallel beta-barrel structures. Our approach consists of repeating eight times a unit peptide designed to adopt ... [more ▼]

We have attempted to construct an artificial polypeptide that folds like the eight-stranded parallel beta-barrel structures. Our approach consists of repeating eight times a unit peptide designed to adopt a 'beta-strand/alpha-helix' pattern. A first 'test' sequence for this structural unit was deduced from a series of parameters defined after an analysis of three natural alpha/beta-barrel proteins and including principally the lengths of the secondary structure elements, the alpha/beta packing and the fitting on average Garnier profiles. The gene encoding this structural unit was synthesized, cloned and expressed in Escherichia coli either as a monomer or as direct repeats of 2-12 units. Preliminary structural characterization of the 7-, 8- and 9-fold unit polypeptides by circular dichroism measurements indicates the presence of the predicted amount of alpha-helix in the three proteins. Further analysis by urea-gradient gel electrophoresis demonstrates that, in the conditions tested, only the 8-fold unit polypeptide forms a compact structure through a cooperative and rapid two-state folding transition involving long-range molecular interactions. [less ▲]

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See detailPlacental and Pituitary Growth Hormone Secretion During Pregnancy in Acromegalic Women
Beckers, Albert ULg; Stevenaert, Achille ULg; Foidart, Jean-Michel ULg et al

in Journal of Clinical Endocrinology and Metabolism (1990), 71(3), 725-31

It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period ... [more ▼]

It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period, pituitary GH secretion is progressively suppressed. The present study was aimed at clarifying the physiology of GH secretion in pregnant acromegalic women. Two young women remained acromegalic despite transphenoidal removal of their pituitary adenoma. Increased basal levels of GH and insulin-like growth factor-I (IGF-I) as well as paradoxical GH release after TRH injection were noted. Both women became pregnant and delivered term babies without any complication. In both patients, pituitary GH remained elevated during the entire pregnancy, contrary to the situation in normal women. Paradoxical GH release after TRH treatment was also present, whereas no response was observed in five normal control subjects. GH pulsatility studies revealed a highly pulsatile secretory pattern of pituitary GH, in contrast to that in normal woman, whose placental GH is secreted tonically. Tissue placental GH concentrations were within the range of levels in normal placentas. An increase in serum IGF-I in late pregnancy was also similar to that observed in normal pregnancy. These findings confirm that increased IGF-I levels are not pituitary GH dependent in late pregnancy. They add new evidence that adenomatous somatotrophs lack an IGF-I-dependent feedback regulation present in normal somatotrophs. [less ▲]

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See detailPRESENCE OF CU-PHYCOERYTHRIN IN THE MARINE BENTHIC BLUE-GREEN-ALGA OSCILLATORIA CF CORALLINAE
Hoffmann, Lucien; Talarico, L.; Wilmotte, Annick ULg

in Phycologia (1990), 29

The presence of CU-phycoerythrin, a phycobiliprotein characterized by the presence of phycourobilin chromophores in addition to phycoerythrobilins, and so far found in only eight blue-green algae, is ... [more ▼]

The presence of CU-phycoerythrin, a phycobiliprotein characterized by the presence of phycourobilin chromophores in addition to phycoerythrobilins, and so far found in only eight blue-green algae, is reported for the first time from a marine benthic blue-green alga, Oscillatoria cf. corallinae. [less ▲]

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See detailLe recours répétitif à l'avortement en Grèce: comportement marginal ou étape du devenir-femme?
Naziri, Despina ULg

in Santé Publique et Sciences Sociales (1990), 8(3), 85-106

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See detailTemple ou bâtiment de prestige ? A propos des temples des périodes d'el-Obed et d'Uruk, et des données ethnoarchéologiques
Tunca, Önhan ULg

in De la Babylonie à la Syrie, en passant par Mari. Mélanges offerts à Monsieur J.-R. Kupper (1990)

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See detailLes fanes de pois constituent-elles un fourrage interessant pour le ruminant?
Leterme, Pascal; Walhain, Philippe; Thewis, André ULg et al

in Agricontact (1990), 219

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See detailSytuacja ekonomiczna belgijskiego rolnictwa
Burny, Philippe ULg; Gazinski, Benon

in Nowe Rolnictwo (1990), (1-2-3), 34-37

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See detailAutoimmune syndrome after neonatal induction of tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity
Merino, J.; Schurmans, Stéphane ULg; Wen, L. et al

in Clinical & Experimental Immunology (1990), 79

The injection of (C57BL/6 x BALB/c) F1 spleen cells into BALB/c newborn mice leads to activation of persisting F1 donor B cells and development of a lupus-like syndrome in tolerized BALB/c mice. This ... [more ▼]

The injection of (C57BL/6 x BALB/c) F1 spleen cells into BALB/c newborn mice leads to activation of persisting F1 donor B cells and development of a lupus-like syndrome in tolerized BALB/c mice. This syndrome is characterized by hypergammaglobulinaemia, high levels of anti-DNA and anti-Sm antibodies, circulating immune complexes and deposits of immunoglobulin in renal glomeruli. The role of donor T cells in this model was investigated by injecting the newborn mice with F1 cells depleted in different T cell subsets by using specific monoclonal antibodies (MoAbs). Tolerance, as shown by an absence of H-2b-specific CTL alloreactivity and persistence of immunoglobulin bearing the donor allotype were observed in mice injected with F1 cells previously depleted in the CD4+ and/or CD8+ T cell subsets as well as in those which received Thy-1+-depleted F1 spleen cells. In these mice, a typical autoimmune syndrome was found, including splenomegaly and lymphadenopathy, anti-ssDNA and anti-aortic myosin IgG antibodies and renal deposition of immunoglobulin. However, some quantitative changes were seen: the levels of anti-aortic myosin antibodies were lower in mice tolerized with CD4+-depleted F1 cells than in those receiving untreated F1 cells. Conversely, higher levels of these autoantibodies were observed in mice tolerized with CD8+-depleted F1 cells. These results suggest that mature donor T cells are not necessary neither for the establishment of neonatal tolerance to alloantigens nor for the activation of F1 donor B cells in the production of the autoimmune syndrome in tolerant mice, but they may contribute in the regulation of the expression of autoreactive B cell clones. [less ▲]

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See detailQuelle approche du langage écrit à la maison et à l'école ?
Delhaxhe, Arlette; Hindryckx, Geneviève ULg; Grisay, Aletta

in Revue Française de Pédagogie (1990), 91

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See detailBovine leukemia : facts and hypotheses derived from the study of an infectious cancer
Burny, A.; Cleuter, Y.; Kettmann, Richard ULg et al

in Retroviruses biology and human disease, Dekker Press (1990)

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See detailDistribution of cyanide content in the lima bean in relation with the intraspecific classification and the seed coat pigmentation.
Baudoin, Jean-Pierre ULg; Barthelemy, Jean-Paul ULg; Ndungo, V. et al

in Annual report of the Bean Improvement Cooperative (1990), 33

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See detailOrganiser la formation continue des enseignants
de Landsheere, Gilbert ULg

in Education-Formation (1990)

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See detailDifférencier l'enseignement : Pourquoi, comment ? Un exemple: la lettre
Moreau, Marie-Louise; Mouvet, Bernadette ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1990), 19

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See detailNO-CARRIER-ADDED (NCA) ARYL [F-18] FLUORIDES VIA THE NUCLEOPHILIC AROMATIC-SUBSTITUTION OF ELECTRON-RICH AROMATIC RINGS
DING, Y. S.; SHIUE, C. Y.; FOWLER, J. S. et al

in Journal of Fluorine Chemistry (1990), 48(2), 189-205

Nucleophilic aromatic substitution by [18F]fluoride ion has been demonstrated on rings containing electron donating groups in addition to the necessary electron withdrawing and leaving groups.

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See detailKinetic mechanism of mitochondria carriers catalysing exchange reactions
Sluse, Francis ULg; Evens, A.; Duyckaerts, Claire ULg et al

in Journal of Biosciences (1990), 15

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See detailTHE MAXIMUM-ENTROPY PRODUCTION PRINCIPLE IN CLIMATE MODELS - APPLICATION TO THE FAINT YOUNG SUN PARADOX
Gérard, Jean-Claude ULg; DELCOURT, D.; François, Louis ULg

in Quarterly Journal Of The Royal Meteorological Society (1990), 116(495), 1123-1132

Current theories of stellar evolution imply that the solar luminosity was 25-30% less than at present during early phases of the Earth's history. The response of the global annual climate to changes of ... [more ▼]

Current theories of stellar evolution imply that the solar luminosity was 25-30% less than at present during early phases of the Earth's history. The response of the global annual climate to changes of the solar input is examined using the maximum entropy production (MEP) principle and a zonal energy balance model including ice-albedo feedback. It is shown that this formulation reproduces satisfactorily the present meridional heat flux and latitudinal temperature distributions. It is found that the model predicts that the efficiency of the meridional heat transport decreases for low values of the solar constant. Consequently, if the solar irradiance is lowered, a progressive development of the polar caps and a decrease of the global surface temperature are obtained without major irreversibility in the system. A comparison with a similar model including diffusive heat transport formalism shows that the value of the critical solar luminosity causing a global glaciation is decreased when the meridional heat fluxes are determined by the MEP principle. [less ▲]

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See detailLa Fédération des Banques de Données Biogéographiques (F.B.D.B.).
Dufrêne, Marc ULg

in I.F.B.L. Feuille de contact trimestrielle (1990), 8

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See detailNouveautés sur le pestivirus BVD/MD et sur l'infection asymptomatique qu'il provoque chez les bovins
Boulanger, Denise; Mignon, Bernard ULg; Waxweiler, Sophie et al

in Annales de Médecine Vétérinaire (1990), 134

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See detailAnxiolytic potential of sulpiride, clozapine and derivatives in the open-field test.
Bruhwyler, J.; Chleide, E.; Liégeois, Jean-François ULg et al

in Pharmacology, Biochemistry & Behavior (1990), 36(1), 57-61

Recently acquired data question the sharp dichotomy between anxiolytics and neuroleptics, since disinhibitory effects have been measured in the rat with very low doses of haloperidol and higher doses of ... [more ▼]

Recently acquired data question the sharp dichotomy between anxiolytics and neuroleptics, since disinhibitory effects have been measured in the rat with very low doses of haloperidol and higher doses of atypical neuroleptics in FI and DRL schedules, but also in the open-field test. That the DA transmission in certain brain regions is involved in some aspects of anxiety has recently been suggested. The present study confirms this hypothesis particularly with high doses of sulpiride (80 mg/kg) and clozapine (24 mg/kg) when tested in the open-field test. Moreover, the results show how a slight chemical modification of clozapine can give a direction to pharmacological activity with one derivative still resembling clozapine and the second one resembling haloperidol. As neuroleptics do not seem to influence the synthesis and utilization of GABA, the higher entry score observed with them would seem to depend above all on DA antagonism in the mesolimbic system. [less ▲]

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See detailGrowth hormone and somatostatin gene expression in pituitary adenomas with active acromegaly and minimal plasma growth hormone elevation
Pagesy, Patrick; Li, Jacques Y.; Rentier-Delrue, Françoise ULg et al

in Acta Endocrinologica (1990), 122(6), 745-752

Some patients with active acromegaly have elevated plasma IGF-I concentrations with only minimal elevation of plasma GH. We compared adenomatous GH and SRIH expression in 3 such patients (patients No. 1 ... [more ▼]

Some patients with active acromegaly have elevated plasma IGF-I concentrations with only minimal elevation of plasma GH. We compared adenomatous GH and SRIH expression in 3 such patients (patients No. 1, 2 and 3; basal plasma GH level < 4 µg/l) and in 3 acromegalic patients with high basal plasma GH level (patients No. 4, 5 and 6; 51.7 ± 16.1 µg/l, mean ± SEM). By immunocytochemistry, all the tumours proved to be somatotropic adenomas. At the ultrastructural level, signs of low secretory activity were observed in adenomas from patients No. 2 and 3. Perifused adenoma cells of patients No. 1, 2 and 3 released very little GH compared with those of patients No. 4, 5 and 6 (1± 0.37 vs 51.5± 34.1 µg · (10–6 cells) · min–1, p< 0.001). Adenoma SRIH content was 65.7 and 30.6 pg/mg proteins in patients No. 1 and 2, whereas it was undetectable in the others (patients No. 4, 5 and 6). Northern blot analysis showed that the GH gene was poorly expressed in the adenomas from patients No. 1, 2 and 3 compared with the adenomas from patients No. 4, 5 and 6. SRIH mRNA was detected in all 6 adenomas. However, the signal was more intense in the adenomas from patients No. 1, 2 and 3 than in those from patients No. 4, 5 and 6. In conclusion, because of the variability of the biosynthetic and secretory potential of the somatotropic adenomas, patients harbouring this type of pituitary tumours can exhibit a wide range of plasma GH levels. In acromegaly with minimal elevation of plasma GH, the synthesis of SRIH by the adenoma cells themselves could play a role in the inhibition of GH expression. [less ▲]

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