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See detailA procedure for deriving accurate linear polarimetric measurements.
Lamy, H.; Hutsemekers, Damien ULg

in The Messenger (1999), 96

The authors present here a procedure written within the ESO MIDAS reduction package with the aim of deriving semi-automatically linear polarisation data from CCD images obtained with beam-splitters such ... [more ▼]

The authors present here a procedure written within the ESO MIDAS reduction package with the aim of deriving semi-automatically linear polarisation data from CCD images obtained with beam-splitters such as those available at the ESO 3.6-m telescope equipped with EFOSC2 or at the VLT equipped with FORS1. The method is adequate for point-like objects and was used for measuring quasar polarisation. [less ▲]

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See detailCanopy gap morphology determinants in an Amazonian rain forest.
Salvador-Van Eysenrode, D; Bogaert, Jan ULg; Impens, I

in Selbyana (1999), 20(2), 339-344

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See detailCharacterization of YKL165c a new essential gene of the yeast Saccharomyces cerevisiae.
Delbecq, Xavier; Godrie, Thérèse ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie et de Biochimie (1999), 107

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See detailAgaristoxylon garennicum gen. et sp. nov., an arborescent Ericaceae from the Belgian Upper Paleocene: palaeoenvironmental implications.
Gerrienne, Philippe ULg; Beeckman, Hans; Damblon, Freddy ULg et al

in Review of Palaeobotany and Palynology (1999), 104

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See detailComparing global models of terrestrial net primary productivity (NPP): analysis of the seasonal atmospheric CO2 signal
Nemry, B.; François, Louis ULg; Gérard, Jean-Claude ULg et al

in Global Change Biology (1999), 5(Suppl. 1), 65-76

Eight terrestrial biospheric models (TBMs) calculating the monthly distributions of both net primary productivity (NPP) and soil heterotrophic respiration (R-H) in the Potsdam NPP Model Intercomparison ... [more ▼]

Eight terrestrial biospheric models (TBMs) calculating the monthly distributions of both net primary productivity (NPP) and soil heterotrophic respiration (R-H) in the Potsdam NPP Model Intercomparison workshop are used to simulate seasonal patterns of atmospheric CO2 concentration. For each model, we used net ecosystem productivity (NEP=NPP-R-H) as the source function in the TM2 atmospheric transport model from the Max-Planck Institute for Meteorology. Comparing the simulated concentration fields with detrended measurements from 25 monitoring stations spread over the world, we found that the decreasing seasonal amplitude from north to south is rather well reproduced by all the models, though the amplitudes are slightly too low in the north. The agreement between the simulated and observed seasonality is good in the northern hemisphere, but poor in the southern hemisphere, even when the ocean is accounted for. Based on a Fourier analysis of the calculated zonal atmospheric signals, tropical NEP plays a key role in the seasonal cycle of the atmospheric CO2 in the whole southern hemisphere. The relatively poor match between measured and predicted atmospheric CO2 in this hemisphere suggests problems with all the models. The simulation of water relations, a dominant regulator of NEP in the tropics, is a leading candidate for the source of these problems. [less ▲]

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See detailProbabilistic design of power-system special stability controls
Wehenkel, Louis ULg; Lebrevelec, Cyril; Trotignon, Marc et al

in Control Engineering Practice (1999), 7(2), 183-194

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and ... [more ▼]

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and fast dynamics, and modeling uncertainties. A large number of scenarios are simulated in parallel by time-domain numerical integration, and the relevant parameters of the resulting system trajectories are stored in a database. Data-mining tools are used to identify the most important system weaknesses and possible improvements. The approach is tested on a large-scale study on the SouthÐEastern part of the extra-high-voltage system of Electricité de France. [less ▲]

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See detailEarly development of the chondrocranium in Chrysichtys auratus (Pisces, Siluriformes, Claroteidae)
Vandewalle, Pierre ULg; Chikou, Antoine; Lalèyé, Philippe et al

in Journal of Fish Biology (1999), 55

The inception and development of the cartilaginous cephalis skeleton of Chrysichthys auratus is described from hatching to about 18 days post-hatching. At hatching, no skeletal structure is present. Not ... [more ▼]

The inception and development of the cartilaginous cephalis skeleton of Chrysichthys auratus is described from hatching to about 18 days post-hatching. At hatching, no skeletal structure is present. Not until day 3 do clearly delimited cranial primordia become apparent. As in many siluriforms, the neurocranium is platybasic from the start, the suspensorium constitutes, with Meckel’s cartilage and the hyoid bar, a single cartilaginous element, and the junction between the front and rear of the neurocranium is complete on day 4. By day 8 the quadratomandibular joint has formed and the tectum posterius has appeared. Cartilage reduction first affects the trabecular bars, then, markedly, the visceral arches. By day 18 the braincase floor has almost disappeared. [less ▲]

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See detailEndogenous auxin and cytokinin levels in shoots of a nonrooting tobacco mutant
Faivre-Rampant, O.; Kevers, Claire ULg; Gaspar, Th

in Bulletin de la Societe Royale des Sciences de Liege (1999), 68(5-6), 318

[No abstract available]

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See detailLes etudes cliniques controlees, support incontournable de la medecine basee sur l'evidence.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1999), 54(1), 1

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See detailAu sujet des cratères lunaires et d'un astronome montois...
Biémont, Emile ULg; Frémat, Y.; Palmeri, P. et al

in Galactée (1999), 16

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See detailCourteous behaviour concerning beetles sexuality
Haubruge, Eric ULg

in New Scientist (1971) (1999), 227(2184), 60

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See detailPrise en charge médico-chirurgicale des enfants cardiopathes: résultats de l'expérience liégeoise
Massin, M.M.; RADERMECKER, Marc ULg; Jalali, H. et al

in Revue Médicale de Liège (1999), 54(2), 95-9

OBJECTIVE: Evaluation of the results obtained in the management of congenital heart diseases in Liege. MATERIAL AND METHODS: We evaluated the results, the mortality and the morbidity of diagnostic and ... [more ▼]

OBJECTIVE: Evaluation of the results obtained in the management of congenital heart diseases in Liege. MATERIAL AND METHODS: We evaluated the results, the mortality and the morbidity of diagnostic and interventional cardiac catheterization, and of the cardiac surgery in the 123 cardiac children who were referred to us during the three first years of operation of our medico-surgical team. RESULTS: 89 children underwent a catheterization, including 12 therapeutic interventions, whereas 68 were operated. In the two domains, the results are completely comparable with those of the established centers. CONCLUSIONS: The widening of the activity of paediatric cardiology and the creation of an activity of pediatric cardiac surgery in Liege appeared important to us for the quality of management of the cardiac children. This goal could be reached only if our results were comparable with those of the literature. The bet seems to be held. The ultimate objective is to contribute by an adequate policy of management to the quality of life and the health of the cardiac children. [less ▲]

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See detailMedicaments et grossesse.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(5), 409-14

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the ... [more ▼]

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the public as well as among medical doctors. However, the complexity of the problem, the lack of robust scientific data and the emotional context characterizing this period make the prescription of medications to a pregnant woman a difficult task for every people involved in health care, the pharmacist, the general practitioner and even the gynaecologist. [less ▲]

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See detailIncreased number of hip fractures.
Gillet, Pierre ULg; Reginster, Jean-Yves ULg

in Lancet (1999), 353(9170), 2160-1

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See detailLymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis.
Baert, F.; Wouters, K.; D'Haens, G. et al

in Gut (1999), 45(3), 375-81

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical ... [more ▼]

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS: Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS: Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis. [less ▲]

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See detailKarst dans les micaschistes d'Akok Bekoé - Sud Cameroun
Willems, Luc ULg; Vicat, Jean-Paul; Pouclet, André

in Bulletin de la Société Géographique de Liège (1999), 37(2), 5-18

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those ... [more ▼]

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those found in the karst limestones. The presence of a spring and the proximity of the Nyong river suggest that a chemical erosion within an aquifer is at the origin of most of forms. The position of certain conduits and tafonis dismisses the assumption of a genesis within a weathering mantle. [less ▲]

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See detailValue of FDG-PET in detecting residual or recurrent nonsmall cell lung cancer
Bury, Thierry ULg; Corhay, Jean-Louis ULg; Duysinx, Bernard ULg et al

in European Respiratory Journal (1999), 14(6), 1376-1380

In order to evaluate the usefulness of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the assessment of therapeutic effects, a study was performed before and after therapy in 126 ... [more ▼]

In order to evaluate the usefulness of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the assessment of therapeutic effects, a study was performed before and after therapy in 126 patients with non-small cell lung cancer (NSCLC) codified stage I to stage IIIB. Treatment with an early curative result was given in 58 patients, whereas in 68 cases it was limited to palliation. During the treatment follow-up period (8-40 months), each patient was evaluated every 3 months by clinical examination and ≤6 months by imaging techniques (PET and computed tomography (CT)). A diagnosis of persistent or recurrent tumour was established by means of pathological analysis in 31 patients and by clinical evolution and subsequent imaging progression in 29 other patients. PET showed increased FDG uptake in all cases (n=60) of persistent or recurrent tumour, whereas CT was nonspecific in 17 cases. Conversely, there were five false positive cases via PET imaging and three via CT. In detecting residual or recurrent NSCLC, PET had a sensitivity of 100% and specificity of 92%, whereas CT had a sensitivity and specificity of 71% and 95% respectively. In conclusion, 18-fluorodeoxyglucose positron emission tomography correctly identified response to therapy in 96% (121 of 126) of patients. Positron emission tomography appears to be more accurate (p=0.05) than conventional imaging in distinguishing persistent or recurrent tumour from fibrotic scar in patients undergoing treatment for non-small cell lung cancer. [less ▲]

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See detailServitude légale d'enclave : introduction de l'action et conciliation préalable obligatoire
Lecocq, Pascale ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailAnalyse préliminaire de la situation et des perspectives de la culture du haricot de Lima (Phaseolus lunatus L.) sur la Côte péruvienne (Vallées d'Ica, Pisco et Casma).
Rouschop, P.; Baudoin, Jean-Pierre ULg; Mayta, F. C. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(2), 115-126

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See detailInfluence function and efficiency of the minimum covariance determinant scatter matrix estimator
Croux, C.; Haesbroeck, Gentiane ULg

in Journal of Multivariate Analysis (1999), 71(2), 161-190

The minimum covariance determinant (MCD) scatter estimator is a highly robust estimator for the dispersion matrix of a multivariate, elliptically symmetric distribution. It is relatively fast to compute ... [more ▼]

The minimum covariance determinant (MCD) scatter estimator is a highly robust estimator for the dispersion matrix of a multivariate, elliptically symmetric distribution. It is relatively fast to compute and intuitively appealing. In this note we derive its influence function and compute the asymptotic variances of its elements. A comparison with the one step reweighted MCD and with S-estimators is made. Also finite-sample results are reported. (C) 1999 Academic Press AMS 1991 subject classifications: 62F35, 62G35. [less ▲]

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See detailRadiative lifetimes in La III and oscillator strengths in La III and Lu III
Biémont, Emile ULg; Li, Z. S.; Palmeri, P. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1999), 32

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See detailSteroid sensitive sites in the avian brain: does the distribution of the estrogen receptor alpha and beta types provide insight into their function?
Ball, G. F.; Bernard, D. J.; Foidart, Agnès ULg et al

in Brain, Behavior & Evolution (1999), 54

Studies in avian species have often been useful in elucidating basic concepts relevant to the regulation of reproductive behaviors by sex steroid hormones. Once a link between a steroid hormone and a ... [more ▼]

Studies in avian species have often been useful in elucidating basic concepts relevant to the regulation of reproductive behaviors by sex steroid hormones. Once a link between a steroid hormone and a behavioral response has been established, one can use the localization of steroid hormone receptors in the brain to facilitate the identification of neural circuits that control behavior. The recent identification of a second type of estrogen receptor called estrogen receptor beta or ERbeta has raised new issues about the action of steroid hormones in the brain. A hypothesis has been proposed by Kuiper et al. [1998] based on studies in mammalian species suggesting that ERalpha (the name given to the ER that was previously described) is important for reproduction while ERbeta is more important for non-reproductive functions. In this paper we apply this hypothesis more generally by examining possible functions of ERbeta in avian species. We have initiated studies of the ERbeta in the brain of two avian species, the Japanese quail (Coturnix japonica) and the European starling (Sturnus vulgaris). ERbeta was cloned in both species and the mRNA for this receptor type was localized in the brain employing in situ hybridization histochemistry methods. In both species ERbeta was found to be diffusely present in telencephalic areas consistent with a role for this receptor subtype in cognitive functions. However, ERbeta mRNA was also found in many brain areas that are traditionally thought to be important in the regulation of reproductive functions such as the preoptic region, the bed nucleus of the stria terminalis and the nucleus taeniae. Of the two receptor types, only mRNA for ERalpha was observed in the telencephalic vocal control nucleus HVc of male starlings. Steroid receptors in this nucleus are thought to be an example of an evolutionary specialization that has evolved to coordinate the production of courtship vocalizations with other aspects of reproduction. The lack of ERbeta mRNA expression in HVc is consistent with the hypothesis that ERalpha is preferentially involved in reproductive behaviors while ERbeta is involved in the steroid regulation of other neural functions. However, the widespread occurrence of ERbeta in other nuclei involved in reproductive function suggests that one must be cautious about the general applicability of the above hypothesis until more is known about ERbeta function in these other nuclei [less ▲]

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See detailPlatyhypnidium mutatum, a mysterious new moss from Germany
Ochyra, R.; Vanderpoorten, Alain ULg

in Journal of Bryology (1999), 21

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See detailDes tableaux d'art dégénéré pour Liège
Duchesne, Jean-Patrick ULg

in Art&Fact (1999), 18

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See detailPhenotypic variation in live weight and live-weight changes of lactating Holstein-Friesian cows
Koenen, Epc.; Groen, Af.; Gengler, Nicolas ULg

in Animal Science (1999), 68

This study quantified individual phenotypic variation in live weight and live-weight changes during the first three lactations and estimated the effects of age, lactation week and pregnancy on live weight ... [more ▼]

This study quantified individual phenotypic variation in live weight and live-weight changes during the first three lactations and estimated the effects of age, lactation week and pregnancy on live weight. Data comprised weekly averaged live weight (calculated from daily observations) during 452 lactations of 239 Holstein-Friesian cows. Unadjusted mean live weights were 553 (s.d. 50), 611 (s.d. 55) and 654 (s.d. 57) kg during first, second and third parity, respectively. Estimated effect of growth during parity was 46, 52 and 23 kg for the first three parities. Mean maximum weight loss was 26, 22 and 22 kg for first, second and third parity and variation was large among individuals. Week of lactation when cows had their maximum weight loss ranged from 7 weeks in first lactation to 13 weeks in third lactation. Estimated maximum effect of pregnancy on live weight during the lactation varied from 27 to 59 kg. Phenotypic variance in live weight increased with parity. Repeatabilities of live-weight observations within parity were 0.85. Across parities, high repeatabilities were found for calving weight and mean live weight but not for parameters associated with maximum weight loss. Correlations between weekly means and mean live weight during the whole of lactation were high. It was concluded that single live-weight observations of heifers are a good measurement of mean live weight during the first three parities. [less ▲]

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See detailDepressive vulnerability is not an independent risk factor for osteoporosis in postmenopausal women.
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Paul, I. et al

in Maturitas (1999), 33(2), 133-7

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy ... [more ▼]

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy postmenopausal women, whether depressive symptomatology, assessed by the General Health Questionnaire (GHQ), was associated to a significant decrease in BMD, hence supporting the hypothesis of an independent pathogenetic link between the two disorders. We investigated 121 postmenopausal women, aged 48-77 years, spontaneously attending a screening visit for osteoporosis in an outpatient facility. BMD of the spine and the non-dominant hip (total and neck areas) were measured by Dual Energy X-Ray absorptiometry. All subjects completed to the 'General Health Questionnaire' translated and validated in French. No significant correlations were observed between the GHQ score and BMD of the spine (P = 0.54), the total hip area (P = 0.65), or the femoral neck area (P = 0.65). No differences in terms of spinal or femoral BMD were observed between women with GHQ score < 5 or > or = 5. When comparing values of BMD between women within the upper and the lower quartiles for GHQ score, no difference was observed for spine (P = 0.69), total hip (P = 0.80), or femoral neck (P = 0.93). Similarly, GHQ scores were not significantly different when comparing women in the upper and lower quartiles of BMD distribution at the spine or the hip. In conclusion, notwithstanding the clinical pattern of postmenopausal osteoporosis can lead to depression and, on the other hand, hormonal and behavioral disturbances reported in depression might be enhancing factors for accelerated bone loss, our present results do not support the hypothesis that otherwise healthy postmenopausal women with increased depressive complaints are also more prone to exhibit osteoporotic fractures. [less ▲]

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See detailL'éclairage : une technique en évolution. De la performance visuelle à l'émotion
Eugène, Christian; Rombauts, Patrick; Embrechts, Jean-Jacques ULg et al

in Revue E Tijdschrift (1999), 115è année, 3/4

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See detailDevelopment of a coupled flow and transport 3D model for simulating seawater intrusions in coastal aquifers
Carabin, Guy; Dassargues, Alain ULg

in Natuurwetenschappelijk Tijdschrift (1999), 79

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See detailKarst dans les évaporites : marqueur efficace des événements récents. L’exemple du Mont Sédom (Israel)
Hallot, Eric ULg

in Bulletin de la Société Géographique de Liège (1999), 37

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See detailLa découverte d'or natif dans le quartzite devellien de Hourt autorise un autre regard sur le site de Rompt-le-Cou
Hanson, Alain ULg; Dehove, J.; Debbaut, Vincent ULg et al

in Glain et Salm. Haute Ardenne (1999), 51

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See detailRadiative Properties of Neutral Germanium obtained from excited-state lifetime and branching-ratio measurements and comparison with theoretial calculations
Li, Z. S.; Norin, J.; Persson, A. et al

in Physical Review. A (1999), 60

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See detailDe la tierce décision obligatoire
Caprasse, Olivier ULg

in Journal des Tribunaux (1999)

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See detailThe Structural And Functional Organization Of H-Ns-Like Proteins Is Evolutionarily Conserved In Gram-Negative Bacteria
Bertin, P.; Benhabiles, N.; Krin, E. et al

in Molecular Microbiology (1999), 31(1), 319-29

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi ... [more ▼]

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi and Haemophilus influenzae. Isolated outside these groups, the BpH3 protein of Bordetella pertussis exhibits a low amino acid conservation with H-NS, particularly in the N-terminal domain. To obtain information on the structure, function and/or evolution of H-NS, we searched for other H-NS-related proteins in the latest databases. We found that HvrA, a trans-activator protein in Rhodobacter capsulatus, has a low but significant similarity with H-NS and H-NS-like proteins. This Gram-negative bacterium is phylogenetically distant from Escherichia coli. Using theoretical analysis (e.g. secondary structure prediction and DNA binding domain modelling) of the amino acid sequence of H-NS, StpA (an H-NS-like protein in E. coli), BpH3 and HvrA and by in vivo and in vitro experiments (e.g. complementation of various H-NS-related phenotypes and competitive gel shift assay), we present evidence that these proteins belong to the same class of DNA binding proteins. In silico analysis suggests that this family also includes SPB in R. sphaeroides, XrvA in Xanthomonas oryzae and VicH in Vibrio cholerae. These results demonstrate that proteins structurally and functionally related to H-NS are widespread in Gram-negative bacteria. [less ▲]

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See detailBiochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the alpha-methyl-L-tryptophan method.
Gharib, Abdallah; Balende, Cédar; Sarda, Nicole et al

in Journal of Neurochemistry (1999), 72(6), 2593-600

Biochemical approaches were used in freely moving rats to determine, under steady-state conditions, the brain/arterial plasma partition coefficients of L-tryptophan and alpha-[3H]methyl-L-tryptophan, from ... [more ▼]

Biochemical approaches were used in freely moving rats to determine, under steady-state conditions, the brain/arterial plasma partition coefficients of L-tryptophan and alpha-[3H]methyl-L-tryptophan, from which the lumped constant for the alpha-methyl-L-tryptophan method of estimating the rate of brain serotonin synthesis is calculated. The lumped constants were significantly different in the various structures examined: 0.149 +/- 0.003 in the raphe dorsalis, 0.103 +/- 0.002 in the raphe centralis, 0.087 +/- 0.003 in the reticular formation, and 0.62 +/- 0.08 in the pineal gland. From these data we proposed a two-compartment model to calculate the rate of serotonin synthesis by quantitative autoradiography using a three-time point experiment. Rates of synthesis for the raphe dorsalis and the reticular formation (620 +/- 57 and 80 +/- 35 pmol/g of tissue/min, respectively) were similar to those measured simultaneously by biochemical means, but rates were 50% higher for the raphe centralis (568 +/- 90 vs. 381 +/- 31 pmol/g of tissue/min). The lack of dynamic equilibrium of the tracer between plasma and tissue pools may explain the discrepancy between the two methods. Our findings did not confirm previous data, indicating that the application of the autoradiographic method to measure the rate of brain serotonin synthesis using alpha-methyl-L-tryptophan as tracer has limitations. [less ▲]

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See detailTarif de cubage "peuplement" pour les mélèzes en belgique méridionale
Pauwels, Dominique; Rondeux, Jacques ULg

in Revue Forestière Française (1999), 51(5), 605-611

Dendrometric data taken from 150 temporary plots set up in even-aged stands of larch trees in southern Belgium (French-speaking region) were used to devise a "stand" volume table that expresses the stem ... [more ▼]

Dendrometric data taken from 150 temporary plots set up in even-aged stands of larch trees in southern Belgium (French-speaking region) were used to devise a "stand" volume table that expresses the stem solid volume (for log girths not less than 22 cm) per hectare of larch depending on the land surface areas and dominant tree heights. [less ▲]

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See detailGalectin-1 Expression in Prostate Tumor-Associated Capillary Endothelial Cells Is Increased by Prostate Carcinoma Cells and Modulates Heterotypic Cell-Cell Adhesion
Clausse, Nathalie; van den Brule, Frédéric; Waltregny, David ULg et al

in Angiogenesis (1999), 3(4), 317-25

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host ... [more ▼]

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host immune cells. Galectin-1, a soluble human lectin, is involved in numerous biological functions including cell-cell and cell-substrate interactions. In addition, galectin-1 is able to induce apoptosis of activated T-lymphocytes. In this study, we have examined galectin-1 expression in capillaries associated to the carcinoma cells or present in the remote non-tumoral stroma of 100 human prostate carcinoma samples by immunoperoxidase staining. Galectin-1 was expressed by endothelial cells from capillaries infiltrating the tumor tissue in 64% (64/100) of the cases. On the contrary, endothelial cells in the adjacent non-tumoral stroma expressed galectin-1 in very few cases (7/100). Increased frequency of galectin-1-positive capillaries in the tumor-associated compared to the tumor-free areas was observed in 63% of the cases. This striking contrast led us to set up an in vitro model to test whether tumor cells could induce galectin-1 expression by endothelial cells. Incubation of human umbilical vein endothelial cells with conditioned media from PC-3 or DU 145 prostate carcinoma cells led to a significant increase of galectin-1 protein expression (+32.97% and 37.91% P < 0.01 and P < 0.05, respectively). PC-3 conditioned medium also induced increased adhesion values of PC-3 cells to the endothelial cells (53.4 +/- 4.7 vs. 38.5 +/- 3.5 after 30 min; 66.6 +/- 7.8 vs. 46.2 +/- 6.4 after 60 min). An anti-galectin-1 antiserum abolished this modulation, and recombinant galectin-1 also induced increased adhesion values in a dose-dependent fashion. This effect was specific as no such modulations were observed using normal lymphocytes instead of PC-3 cells. Preferential galectin-1 expression in the endothelial cells close to the cancer cells could provide these latter with increased abilities to interact with the endothelial cells as well as a defense against the host immune system. [less ▲]

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See detailConsensus statement on the treatment of septic shock
Spapen, H.; Damas, Pierre ULg; D'Orio, Vincenzo ULg et al

in Acta Clinica Belgica (1999), 54(5), 256-262

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See detailThe Crystal Structure Of A Penicilloyl-Serine Transferase Of Intermediate Penicillin Sensitivity - The Dd-Transpeptidase Of Streptomyces K15
Fonze, E.; Vermeire, M.; Nguyen-Disteche, M. et al

in Journal of Biological Chemistry (1999), 274(31), 21853-60

The serine DD-transpeptidase/penicillin-binding protein of Streptomyces K15 catalyzes peptide bond formation in a way that mimics the penicillin-sensitive peptide cross-linking reaction involved in ... [more ▼]

The serine DD-transpeptidase/penicillin-binding protein of Streptomyces K15 catalyzes peptide bond formation in a way that mimics the penicillin-sensitive peptide cross-linking reaction involved in bacterial cell wall peptidoglycan assembly. The Streptomyces K15 enzyme is peculiar in that it can be considered as an intermediate between classical penicillin-binding proteins, for which benzylpenicillin is a very efficient inactivator, and the resistant penicillin-binding proteins that have a low penicillin affinity. With its moderate penicillin sensitivity, the Streptomyces K15 DD-transpeptidase would be helpful in the understanding of the structure-activity relationship of this penicillin-recognizing protein superfamily. The structure of the Streptomyces K15 enzyme has been determined by x-ray crystallography at 2.0-A resolution and refined to an R-factor of 18.6%. The fold adopted by this 262-amino acid polypeptide generates a two-domain structure that is close to those of class A beta-lactamases. However, the Streptomyces K15 enzyme has two particular structural features. It lacks the amino-terminal alpha-helix found in the other penicilloyl-serine transferases, and it exhibits, at its surface, an additional four-stranded beta-sheet. These two characteristics might serve to anchor the enzyme in the plasma membrane. The overall topology of the catalytic pocket of the Streptomyces K15 enzyme is also comparable to that of the class A beta-lactamases, except that the Omega-loop, which bears the essential catalytic Glu(166) residue in the class A beta-lactamases, is entirely modified. This loop adopts a conformation similar to those found in the Streptomyces R61 DD-carboxypeptidase and class C beta-lactamases, with no equivalent acidic residue. [less ▲]

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See detailDescription de trois cas autochtones de babésiose canine (Babesia canis) en Belgique
Losson, Bertrand ULg; Mollet, J. J.; Avez, F. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailLes conditions de la rentabilité de la production d'embryons bovins par ponction folliculaire échoguidée et fécondation in vitro en Région Wallonne : première approche.
Dehareng, D.; Annet, C.; Dupont, F. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailA novel gene overexpressed in the prostate of castrated rats: hormonal regulation, relationship to apoptosis and to acquired prostatic cell androgen independence.
Bruyninx, M.; Hennuy, Benoît ULg; Cornet, Anne ULg et al

in Endocrinology (1999), 140(10), 4789-99

We have identified a novel complementary DNA (cDNA) corresponding to a gene overexpressed in the rat ventral prostate after castration. This cDNA displays 89.4% identity with 453 bp of a mouse EST and 81 ... [more ▼]

We have identified a novel complementary DNA (cDNA) corresponding to a gene overexpressed in the rat ventral prostate after castration. This cDNA displays 89.4% identity with 453 bp of a mouse EST and 81.5% identity with 157 bp of a human EST and was named PARM-1 for prostatic androgen-repressed message-1. The complete cDNA is 1187 bp long and codes for a protein of 298 amino acids that contains four potential glycosylation sites and three half cystinyl residues. The PARM-1 gene was found to be expressed at quite low levels in most rat tissues including those of the urogenital tract. The kinetic of induction of PARM-1 gene in the prostate was highly correlated to the development of apoptosis in the whole organ. Supplementation of castrated animals with androgens reversed both the process of apoptosis and the overexpression of PARM-1 gene. Supplementation with estrogens did not result in an increase in the PARM-1 messenger RNA levels when compared with the castration alone. However, the treatment resulted in a more rapid return to intact levels in the castrated plus estrogen group. When apoptosis of testis and prostate was induced in vivo by hypophysectomy, it was found that PARM-1 was only overexpressed in the prostate. Therefore, PARM-1 seems to be regulated by androgens only in the prostate. Using in situ hybridization and immunohistological techniques, we have shown that PARM-1 gene product is found exclusively in the epithelial cells of involuting prostate. Analysis by flow cytometry of MAT LyLu epithelial cells transiently expressing PARM-1 protein did not allow us to demonstrate a direct effect of PARM-1 gene overexpression on the programmed death of the transfected cells. Treatment of MAT LyLu cells by transforming growth factor-beta induced apoptosis but had no effect on PARM-1 production. However PARM-1 protein has been detected by Western blotting in various cell lines such as MAT LyLu, MAT Lu, and PIF, which are androgen independent. This would suggest that PARM-1 gene product would be a marker for acquired androgen-independence of these tumor cells. [less ▲]

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See detail"Le choix de la voie la plus onéreuse sanctionné par la condamnation aux dépens"
Moreau, Pierre ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederechters (1999), (8, 9, 10), 345-348

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See detailHypnoanesthesia for endocrine cervical surgery: a statement of practice.
Defechereux, Thierry ULg; Meurisse, Michel ULg; Hamoir, Etienne ULg et al

in Journal of Alternative & Complementary Medicine : Research on Paradigm, Practice, & Policy (1999), 5(6), 509-20

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and ... [more ▼]

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnoanesthesia (HYP) using Erikson's method. Operative data and postoperative course of this initial series were compared to a contemporary population of patients (n = 119) clinically similar except that they declined HYP or were judged unsuitable for it, and who were therefore operated on under general anesthesia (GA). RESULTS: The surgeons all reported better operating conditions for cervicotomy using HYP. Conversion from hypnosis to GA was needed in two cases (1%). All patients having HYP reported a pleasant experience and, keeping in mind that the GA group is not a randomly assigned control group, both had significantly less postoperative pain and analgesic use. Hospital stay was also significantly shorter, providing a substantial reduction in the costs of medical care. The postoperative convalescence was significantly improved after HYP and a full return to social or professional activity was significantly quicker. CONCLUSION: From this study, we conclude that HYP is an effective technique for providing relief of intraoperative and postoperative pain in endocrine cervical surgery. The technique results in high patient satisfaction and better surgical convalescence. This technique can therefore be used in most well-chosen patients and reduces the socioeconomic impact of hospitalization. [less ▲]

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See detailDiabete gestationnel: signification pronostique pour l'enfant.
Geronooz, I.; Scheen, André ULg; Senterre, Jacques ULg

in Revue Médicale de Liège (1999), 54(6), 517-21

Gestational diabetes, even if it seems to induce far less foetal complications than classical type 1 or type 2 diabetes mellitus, may be deleterious for the child. We will successively consider the ... [more ▼]

Gestational diabetes, even if it seems to induce far less foetal complications than classical type 1 or type 2 diabetes mellitus, may be deleterious for the child. We will successively consider the complications that could affect the child during gestation, during the neonatal period and during adult life. These consequences for the offspring require optimal screening and management of gestational diabetes mellitus. [less ▲]

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See detailLocal order of the high-pressure metallic phase of liquid selenium: a diffraction study
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Le Bihan, T. et al

in Journal of Physics : Condensed Matter (1999), 11(50), 10243-1024910249

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength ... [more ▼]

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength of 0.149 Aring to investigate the local order of the metallic liquid. The diffraction pattern of liquid Se has been recorded with the large-volume Paris-Edinburgh cell between (20degC, 3 GPa) and (1650degC, 4.1 GPa). The local order of the metallic liquid selenium is found to be close to that of liquid tellurium. In particular, the coordination number Z increases with temperature from 2.6 to 3.0 [less ▲]

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See detailBovine brucellosis diagnosis by skin test: conditions for its use and evaluation of its performance
Saegerman, Claude ULg; Vo, T. K. O.; De Waele, L. et al

in Veterinary Record : Journal of the British Veterinary Association (1999), 145

Brucellergene OCB (Rhône-Mérieux) was used as an allergen to define the intrinsic parameters of a skin test and to compare its properties with serology for the diagnosis of bovine brucellosis. The skin ... [more ▼]

Brucellergene OCB (Rhône-Mérieux) was used as an allergen to define the intrinsic parameters of a skin test and to compare its properties with serology for the diagnosis of bovine brucellosis. The skin test was also evaluated for its capacity to solve problems associated with false positive reactions in serological tests. The optimal reading delay for the skin test was 72 hours. The brucellosis allergic reaction was two to three times less intense than the tuberculosis allergic reaction. An increase of 1.1 mm or more in the skin thickness was therefore considered to be an adequate cut-off. The specificity calculated for 1192 brucellosis-free animals (including animals from brucellosis-free herds in which false positive serological reactions had been reported) was 99-83 per cent (95 per cent confidence interval [CI] 99-40 to 99-98 per cent). The sensitivity determined from 27 experimentally infected heifers ranged from 93 per cent (95 per cent CI 76 to 100 per cent) to 78 per cent (95 per cent CI 58 to 91 per cent) when measured respectively one and six months after the infection. Allergic reactions could be detected in vaccinated animals up to four-and-a-half years after the vaccination. On the other hand, no sensitisation was recorded in naïve animals after up to eight monthly injections of the allergen. The skin test gave valuable information, in combination with the serological tests, in both acute and chronic brucellosis. The skin test discriminated brucellosis clearly from false positive serological reactions due to infections with Yersinia enterocolitica O9. [less ▲]

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See detailEpidémiosurveillance de l'encéphalopathie spongiforme bovine en Belgique : bilan de l'année 1998
Saegerman, Claude ULg; Dechamps, P.; Vanopdenbosch, E. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailImpact of dolomite lime on the ground vegetation and on potential net N transformations in Norway spruce (Picea Abies (L.) Karst.) and sessile oak (Quercus Petraea (Matt.) Lieb.) stands in the Belgian Ardenne
Duliere, J.-F.; Carnol, Monique ULg; Dalem, S. et al

in Annals of Forest Science : a Multidisciplinary and International Journal (1999), 56

The impact of dolomite lime (5 T·ha-1) on the ground vegetation and on potential net nitrogen (N) transformations was investigated in two Belgian forest ecosystems. Norway spruce (Picea abies (L.) Karst ... [more ▼]

The impact of dolomite lime (5 T·ha-1) on the ground vegetation and on potential net nitrogen (N) transformations was investigated in two Belgian forest ecosystems. Norway spruce (Picea abies (L.) Karst.) and sessile oak (Quercus petraea (Matt.) Lieb.) stands were situated in the Haute Ardenne (east Belgium) on acid-brown soil. The herb-layer floristic richness increased during the 2 years following liming, with the appearance of light and N-demanding species, which are also found in clear-cut areas or on road verges. Mosses reacted rapidly, showing a decrease acidophilous-dominant species and the establishment of some ruderal species. Six months after liming, the pH was significantly increased in the organic horizon of both stands and in the organomineral horizon of the oak stand. Soils originating from the two stands showed distinct responses in net NO3- production to the dolomite lime treatment. In the organic layer of the Quercus soil, net NH4+ production was decreased, NO3- production increased, and total N mineralisation remained unchanged. In the organomineral layer, NO3 - production was increased. In the Picea soil, NO3 - production was decreased in the organomineral soil layer. These results indicate the possibility of differences in the control of the N transformation processes occurring in the two sites. [less ▲]

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See detailMinimal influence of the time interval between injection of regular insulin and food intake on blood glucose control of type 1 diabetic patients on a basal-bolus insulin scheme.
Scheen, André ULg; Letiexhe, Michel ULg; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1999), 25(2), 157-62

The present study aimed at investigating the influence of the time interval between injection of regular insulin and meal ingestion on postprandial glucose changes and overall blood glucose control in ... [more ▼]

The present study aimed at investigating the influence of the time interval between injection of regular insulin and meal ingestion on postprandial glucose changes and overall blood glucose control in patients with type 1 diabetes on intensive insulin therapy. Fifteen C-peptide negative subjects were submitted, in a randomized order, to two 6-week treatment periods in which regular insulin was injected either 5 minutes or 30 minutes before each of the three main meals, in combination with a bedtime NPH insulin injection. The changes in plasma glucose excursions following a breakfast test (Cmax, Tmax, Cmin, Tmin, AUC0-240 min) were similar in the two experimental protocols. Furthermore, no significant changes were observed in daily insulin dosages nor in glucose profiles obtained using home blood glucose monitoring. Only a tendency to a greater 90-minutes postprandial increase in blood glucose levels was observed when regular insulin was injected 5 minutes rather than 30 minutes before meal. Glycated haemoglobin levels were similar after each treatment period (7.6 +/- 0.2% versus 7.5 +/- 0.2%; NS) and no differences in the incidence or severity of hypoglycaemic episodes were noticed between the two insulin schemes. In conclusion, in type 1 diabetic patients who are rather well controlled with a basal-bolus insulin scheme, the injection of regular insulin 30 minutes before each main meal provides no significant advantage as compared to the injection of regular insulin 5 minutes before meal. [less ▲]

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See detailEnquête sur le "pouvoir thérapeutique" des dauphins
Servais, Véronique ULg

in Recherches en Communication (1999), 12

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest ... [more ▼]

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest that the "therapeutic effect" of animals are very sensitive to the experimental setting designed to demonstrate them. They tend to disappear in very stricly controlled conditions. The study also shows that the hypothesis that talk about "therapeutic effect" of animals are formally analogous to the magical talks about dolphin's "power to heal". [less ▲]

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See detailInteractively converging on context-sensitive representations: a solution to the frame problem
French, Robert M; Anselme, Patrick ULg

in Revue Internationale de Philosophie (1999), 209(3), 365-385

While we agree that the frame problem, as initially stated by McCarthy and Hayes (1969), is a problem that arises because of the use of representations, we do not accept the anti-representationalist ... [more ▼]

While we agree that the frame problem, as initially stated by McCarthy and Hayes (1969), is a problem that arises because of the use of representations, we do not accept the anti-representationalist position that the way around the problem is to eliminate representations. We believe that internal representations of the external world are a necessary, perhaps even a defining feature, of higher cognition. We explore the notion of dynamically created context-dependent representations that emerge from a continual interaction between working memory, external input, and long-term memory. We claim that only this kind of representation, necessary for higher cognitive abilities such as counterfactualization, will allow the combinatorial explosion inherent in the frame problem to be avoided. Introduction You live in a tidy little suburb of America. You call up a friend and invite him to have a drink. He agrees to meet you at seven. But then, just before you hang up, he adds, 'Unless my wife has scheduled something else for this evening.' You think: that's reasonable. Then he adds, 'Unless the bar doesn't exist anymore.' You think: that's a bit strange since the bar was there three months before. Then he adds, 'Unless I'm killed on the way there.' You begin to wonder if you really want to have a drink with him. And finally, he adds, 'Unless a meteorite destroys the earth' and you suddenly remember a prior engagement. But what, exactly, makes some of these conditions perfectly reasonable, others crazy? The philosophical problem is that we cannot exclude any of them a priori because contexts do exist in which they would be perfectly appropriate remarks. For example, if the bar in question was a theme bar devoted to punk rock music, or if the conversation had occurred in London in 1942 or in Sarajevo fifty years later, or if on that day the earth happened to be passing through a dense band of meteorites the size of Madagascar.... [less ▲]

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See detailQuantitative palynology of Famennian events in the Ardenne-Rhine Regions.
Streel, Maurice ULg

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailGlucose metabolism and the postprandial state.
Lefebvre, Pierre ULg; Scheen, André ULg

in European Journal of Clinical Investigation (1999), 29 Suppl 2

Disturbances of postprandial glucose metabolism are now thought to contribute to cardiovascular disease. Postprandial glucose excursions can be affected by a number of factors, such as the types of ... [more ▼]

Disturbances of postprandial glucose metabolism are now thought to contribute to cardiovascular disease. Postprandial glucose excursions can be affected by a number of factors, such as the types of carbohydrates ingested and the way they are metabolized. In Type 2 diabetes, factors that contribute to excessive postprandial glucose excursions include disruption of insulin secretion, insufficient inhibition of hepatic glucose production and defective glucose storage in muscle. A number of measures may attenuate excessive postprandial blood glucose excursions. These include a diet high in 'low glycaemic index' foods and treatment with drugs that improve or restore the hormonal response (e.g. the sulphonylureas and the newer beta-cell mediated insulinotropic drugs such as repaglinide), that improve insulin sensitivity or that delay gastric emptying. [less ▲]

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See detailStructure of high temperature fluid selenium
Bichara, C.; Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg

in Journal of Non-Crystalline Solids (1999), 250-252

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures ... [more ▼]

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures obtained are in agreement with the X-ray scattering and extended X-ray absorption fine structure (EXAFS) data in a range of temperatures and densities. A correlation between the conductivity of high temperature fluid selenium and the degree of branching and breaking of the selenium chains is observed [less ▲]

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See detailCorticomotoneuronal synaptic connections in normal man. An electrophysiological study.
Maertens de Noordhout, Alain ULg

in Brain : A Journal of Neurology (1999), 122

In order to determine the mono- or oligosynaptic character of connections between pyramidal axons and individual spinal motor neurons, we constructed peri-stimulus time histograms (PSTHs) of the firing ... [more ▼]

In order to determine the mono- or oligosynaptic character of connections between pyramidal axons and individual spinal motor neurons, we constructed peri-stimulus time histograms (PSTHs) of the firing probability of voluntarily activated single motor units (SMUs) of various upper and lower limb muscles upon slightly suprathreshold transcranial anodal electrical stimulations of the motor cortex in normal subjects. Weak anodal cortical stimuli are known to activate preferentially fast-conducting pyramidal axons directly, bypassing cell bodies and cortical interneurons. A narrow bin width (0.1 ms) was chosen to measure precisely the duration of the PSTH excitatory peak, which corresponds to the rise time of the underlying compound excitatory post-synaptic potentials (EPSP). A short duration PSTH peak indicates sharp-rising EPSPs, most commonly encountered in the case of monosynaptic connections. In flexor carpi radialis and soleus SMUs, the PSTHs of built-in responses to anodal cortical stimuli were compared with those produced by 1A afferent stimulation able to elicit a Hoffmann reflex, which is known to be largely monosynaptic. In all upper and lower limb muscles, excitable SMUs responded to anodal cortical stimuli with a highly synchronized peak of increased firing probability. In flexor carpi radialis and soleus SMUs, the mean duration of this peak was significantly narrower than that evoked by 1A afferent stimulation, indicating that monosynaptic corticomotor neuronal transmission dominates low-threshold motor units, even in proximal arm and leg muscles. In the various muscles studied, and particularly in forearm SMUs, we did not observe broad PSTH peaks against the activation of non-monosynaptic corticomotor neuronal pathways, even with near-threshold stimuli. In some triceps and forearm flexor SMUs, subthreshold anodal pulses caused significant inhibition of their voluntary firing, with a latency consistent with activation of 1A inhibitory interneurons by the descending volleys. Measurements of the maximal number of counts in the excitatory PSTH peak upon anodal cortical stimuli provide comparisons of the strength of monosynaptic inputs to various muscles which seems to be maximal for hand and finger extensor muscles, and also for deltoid. [less ▲]

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See detailPrognostic Factors in Urothelial Renal Pelvis and Ureter Tumours: a Multicentre Rare Cancer Network Study
Ozsahin, M; Zouhair, A; Villa, S et al

in European Journal of Cancer & Clinical Oncology (1999), 35/5

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter ... [more ▼]

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n=71), nephroureterectomy and lymphadenectomy (n=20), nephroureterectomy and partial bladder resection or transurethral resection (n=20), nephrectomy (n=10), and ureterectomy (n=5). Sixty-one per cent (n=77) of the tumours were located in the renal pelvis, and 21% (n=27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis. [less ▲]

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See detailHow To Bring Orphan Genes Into Functional Families
Bianchi, Mm.; Sartori, G.; Vandenbol, Micheline ULg et al

in Yeast (1999), 15(6),

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See detailPharma clinics. Comment je traite ... la sténose d'artère rénale
Krzesinski, Jean-Marie ULg; Turatzinze, Léopold

in Revue Médicale de Liège (1999), 54(9), 719-721

Renal artery stenosis is mainly due to atherosclerosis, but also to fibromuscular dysplasia. Treatment can consist eisther of angioplasty (± stent) or of surgical revascularization. Hypertension induced ... [more ▼]

Renal artery stenosis is mainly due to atherosclerosis, but also to fibromuscular dysplasia. Treatment can consist eisther of angioplasty (± stent) or of surgical revascularization. Hypertension induced by atherosclerotic disease is rarely cured, but more easily controlled. The renal function is often improved and thus this disease must be searched in the presence of renal insufficiency of unknown cause or refractory hypertension. [less ▲]

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See detailMalathion Resistance Increases Male Reproductive Success In Tribolium Castaneum (Coleoptera : Tenebrionidae)
Arnaud, L.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Annales de la Societe Entomologique de France (1999), 35

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See detailUn goût de lire bien mesuré: Elaboration et mise à l'essai d'une échelle d'attitudes envers la lecture
Lafontaine, Dominique ULg

in Mesure et Evaluation en Education [=MEE] (1999), 22(1), 21-43

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See detailRadio-oncologie et radiothérapie. Confirmation de l'efficacité des radiations ionisantes en oncologie, et renouveau de leur intérêt dans les affections non oncologiques : Acquisitions thérapeutiques 1998
OZSAHIN; MIRIMANOFF; PICA, A et al

in Médecine et Hygiène (1999), 54(2238), 100-111

En 1998, plusieurs études ont clarifié ou confirmé l'effet positif de la radiothérapie dans le cancer du sein in situ, dans différents types de lymphomes non hodgkinien et hodgkinien, et dans le cancer ... [more ▼]

En 1998, plusieurs études ont clarifié ou confirmé l'effet positif de la radiothérapie dans le cancer du sein in situ, dans différents types de lymphomes non hodgkinien et hodgkinien, et dans le cancer bronchique à petites cellules. Deux métaanalyses par contre semblent remettre en cause la radiothérapie, dans la maladie de Hodgkin de stade avancé et dans l'approche postopératoire du cancer ronchique à non petites cellules. Ces méta-analyses comportent toutefois d'importantes faiblesses et doivent être interprétées de façon critique. Dans le domaine technique de la radio-oncologie, les progrès spectaculaires de la planification assistée par ordinateur et l'intégration de l'imagerie IRM peuvent maintenant s'appliquer aussi à la curiethérapie. Enfin, la radiothéraple dans les affections non oncologiques suscite un nouvel intérêt, comme par exemple la curiethérapie intracoronarienne, un traitement prometteur pour prévenir la resténose coronarienne. [less ▲]

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See detailLes Caecilii, la Sicile et le judaïsme
Rochette, Bruno ULg

in Maia (1999), 51

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See detailRecommendations for the registration of drugs intended for use in the treatment of male osteoporosis
Kaufman, JM; Compston, J; Audran, MA et al

in Calcified Tissue International (1999), 65

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See detailQu'est-ce que bien enseigner ? : éléments de réponse suggérés par la psychologie cognitive
Crahay, Marcel ULg

in Réflexions (1999), (36039), 19-23

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See detailbeta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: Relevance to Alzheimer's disease
Pillot, T.; Goethals, M.; Najib, J. et al

in Journal of Neurochemistry (1999), 72(1), 230-7

Growing evidence indicates the involvement of apolipoprotein E (apoE) in the development of late-onset and sporadic forms of Alzheimer's disease, although its exact role remains unclear. We previously ... [more ▼]

Growing evidence indicates the involvement of apolipoprotein E (apoE) in the development of late-onset and sporadic forms of Alzheimer's disease, although its exact role remains unclear. We previously demonstrated that beta-amyloid peptide (Abeta) displays membrane-destabilizing properties and that only apoE2 and E3 isoforms inhibit these properties. In this study, we clearly demonstrate that the carboxy-terminal lipid-binding domain of apoE (e.g., residues 200-299) is responsible for the Abeta-binding activity of apoE and that this interaction involves pairs of apoE amphipathic alpha-helices. We further demonstrate that Abeta is able to inhibit the association of the C-terminal domain of apoE with lipids due to the formation of Abeta/apoE complexes resistant to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. On the contrary, the amino-terminal receptor-binding domain of apoE (e.g., residues 129-169) is not able to form stable complexes with Abeta. These data extend our understanding of human apoE-dependent binding of Abeta by involving the C-terminal domain of apoE in the efficient formation of apoE/Abeta complex. [less ▲]

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See detailHistoire de la vallée de l'Euphrate entre le barrage de Teshrine et Karkemish aux IIIe et IIe millénaires av. J. C
Tunca, Önhan ULg; Lacambre, Denis

in Archaeology of the Upper Syrian Euphrates. The Tishrin Dam Area. Proceedings of the International Symposium Held at Barcelona (1999)

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See detailLicéité des baux au regard de la police de l'aménagement du territoire et de l'urbanisme
Delnoy, Michel ULg

in Actualités Juridiques des Baux (1999)

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See detailPrevalence of hepatitis G virus in a haemodialysis unit
Lamproye, Anne ULg; Delwaide, Jean ULg; Vaira, Dolorès ULg et al

in Acta Gastro-Enterologica Belgica (1999), 62(1), 13-15

Background : Recently, a novel blood-borne virus has been identified and named hepatitis G virus. Transfusion is the main route of transmission. It is known that patients on maintenance dialysis are more ... [more ▼]

Background : Recently, a novel blood-borne virus has been identified and named hepatitis G virus. Transfusion is the main route of transmission. It is known that patients on maintenance dialysis are more susceptible to infections with parenterally-transmitted viruses than the general population. The aim of the present study was to determine the prevalence of hepatitis G infection in a Belgian dialysis unit. Methods: The entire population of our dialysis unit (82 patients) was tested for the presence of hepatitis G virus (HGV) by reverse transcriptase polymerase chain reaction. History of transfusion or renal transplantation coinfections with hepatitis B and C viruses, and serum aminotransferase levels were also tested. Results: Thirteen patients (16%) were found positive for HGV-RNA. Among these patients, 69.2% were infected by the G virus alone, 15.4% were coinfected with B virus, and 15.4% with C virus. All but one patient had a history of transfusion. Ten of the thirteen infected patients (77%) had normal aminotransferase (< 30 UI/l). Three patients had elevated aminotransferase levels (23%); one was coinfected with B virus, one with C virus, and the last one had a diabetes-induced fatty liver infiltration. No liver biopsies were performed. Conclusions :It is concluded that infection with C virus is common among dialyzed patients. This high rate of infection could be related to previous transfusions, but may as well be due to nosocomial transmission. In our series, at least one patient has been contaminated by another road than transplantation or transfusion. Finally, it does not appear clearly that chronic infection with hepatitis G virus induces Liver disease, as defined by elevated aminotransferase level. [less ▲]

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See detailCardiac autonomic dysfunction in diabetic children.
Massin, M. M.; Derkenne, B.; Tallsund, M. et al

in Diabetes care (1999), 22(11), 1845-50

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can ... [more ▼]

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can be used to detect subclinical autonomic neuropathy in diabetic children. RESEARCH DESIGN AND METHODS: We examined five time domain and three frequency domain HRV indices determined from 24-h Holter recordings in 73 diabetic children and adolescents aged 3-18 years (mean 12.1 years) with a mean duration of diabetes of 55 months. The measures were compared with normal ranges. Z scores were established for each parameter and were compared with classic risk factors of other diabetic complications. RESULTS: Most HRV indices were significantly depressed in children aged > or = 11 years, and the levels of HRV abnormalities were significantly correlated with long-term metabolic control (mean GHb for 4 years) in that age-group. In younger patients, HRV indices were within the normal range and were not correlated with the level of metabolic control. Illness duration and microalbuminuria but not short-term metabolic control (most recent GHb) were also independently predictive of HRV abnormalities. CONCLUSIONS: These results suggest that early puberty is a critical period for the development of diabetic cardiac autonomic dysfunction. Therefore, all type 1 diabetic patients should be screened for this complication by HRV analysis beginning at the first stage of puberty regardless of illness duration, microalbuminuria, and level of metabolic control. [less ▲]

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See detailLe diabete gestationnel: physiopathologie et signification pronostique pour la mere.
Geronooz, I.; Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (1999), 54(5), 434-9

Pregnancy is associated with important changes in mother metabolism, especially in late gestation, among which a decreased glucose tolerance caused by insulin resistance. In some of these women, glucose ... [more ▼]

Pregnancy is associated with important changes in mother metabolism, especially in late gestation, among which a decreased glucose tolerance caused by insulin resistance. In some of these women, glucose intolerance is increased by a defect in B-cell function and diabetes mellitus occurs. These women who develop a gestational diabetes need a close follow-up because they are at high risk for further development of diabetes, especially type 2 diabetes. [less ▲]

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See detailH-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase
Damblon, Christian ULg; Prosperi, Christelle ULg; Lian, L. Y. et al

in Journal of the American Chemical Society (1999), 121(49), 11575-11576

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See detailStudy of the mechanism of direct laser desorption/ionisation for some small organic molecules (M < 400 daltons)
Benazouz, M.; Hakim, B.; Debrun, J. L. et al

in Rapid Communications in Mass Spectrometry : RCM (1999), 13(23), 2302-2304

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates ... [more ▼]

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates, and a nitrogen laser is used for desorption/ionisation; ion yields are measured with a time-of-flight mass spectrometer, Previous work had shown that ion yields can strongly vary from one substrate to another, and that this variation does not reflect the (calculated) metal surface temperatures. New results obtained in this work indicate that the desorption/ionisation mechanism is linked to the physical state of the substrate surface. Copyright (C) 1999 John Wiley & Sons, Ltd. [less ▲]

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See detailEffects on nicotine administered via a transdermal delivery system on vigilance : a repeated measure study
Mancuso, Giovanna; Andrès Bénito, Pilar; Ansseau, Marc ULg et al

in Psychopharmacology (1999), 142(1), 18-23

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing ... [more ▼]

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing test 1.3, 3 and 6.3 hrs after patch application, to verify the involvement of the dose of nicotine on the performance. The results confirm and extend the knowledge on the increasing effects of nicotine on vigilance previously found with orally and transdermally administered nicotine. Moreover, results show that such performance was independent of the time of nicotine absorption, which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time. ((c) 1999 APA/PsycINFO, all rights reserved) [less ▲]

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See detailCD44v6 expression is an independent prognostic factor in node-negative FIGO stage IB cervical carcinoma.
Speiser, P.; KRIDELKA, Frédéric ULg; Tempfer, C. et al

in International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society (1999), 9(2), 160-165

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing ... [more ▼]

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing receptor," CD44 is physiologically involved in migration of circulating lymphocytes to lymphatic tissue. In the present study, we investigated the expression of CD44v3 and v6 in 237 patients with stage IB, N0 cervical carcinoma by means of immunohistochemistry. These results were correlated with the GOG score and other prognostic variables. Median follow-up was 82.6 months (39-110 months). Thirty-nine patients recurred and 35 died from disease within the observation period. In univariate analysis, the GOG score, histologic subtype, and CD44v6 expression were statistically significant predictors for poor overall survival (OS). In multivariate (Cox regression) analysis, the GOG score (< 40 vs. 40-120, RR: 1.37 (95% CI: 1.10-1.71); 40-120 vs. > 120, RR: 2.23 (95% CI: 1.28-3.88); P = 0.004), histologic subtype (adenosquamous carcinomas) (RR: 4.56 (95% CI: 1.49-13.92), P = 0.007) and CD44v6 expression (RR: 2.42 (95% CI: 1.14-5.10), P = 0.021) were independent predictors for poor OS. The expression of CD44v3 did not correlate with prognosis. Furthermore we found a strong correlation between CD44v6 expression and lymphovascular space invasion (LVSI) (chi2 = 17.01, P = 0.0001). Tumor expansion into the loco-regional lymphatic system is the preferred way of tumor spread in cervical carcinoma. The strong correlation of CD44v6 with LVSI produces a significant degree of suspicion that cervical carcinoma cells expressing CD44v6 could, by mimicking lymphocytes, exploit their pathways. [less ▲]

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See detailDe Plantin à Deman. Pour une histoire des pratiques d’édition en Belgique
Durand, Pascal ULg; Winkin, Yves

in Textyles : Revue des Lettres Belges de Langue Française (1999), 15

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See detailTroubles psychiatriques et dangerosité
Papart, Patrick ULg

in Acta Psychiatrica Belgica (1999), 99

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See detailDo babies resemble their fathers more than their mothers ? : a failure to replicate Christenfeld and Hill
Brédart, Serge ULg; French, R.

in Evolution and Human Behavior : Official Journal of the Human Behavior and Evolution Society (1999), 20(3), 129-135

Contrary to Christenfeld

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See detailLifetime measurements in Yb II with time-resolved laser spectroscopy
Li, Z. S.; Svanberg, S.; Quinet, Pascal ULg et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1999), 32

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See detailQuelques remarques sur la place du ciel dans le bouddhisme
Verpoorten, Jean-Marie ULg

in Acta Orientalia Belgica (1999), XII

Paradoxalement le bouddhisme recommande à ses moines de ne pas attacher d’importance à ce qui échappe aux sens : les dieux, le ciel et l’enfer, l’âme et son avenir transmigratoire, mais sa littérature est ... [more ▼]

Paradoxalement le bouddhisme recommande à ses moines de ne pas attacher d’importance à ce qui échappe aux sens : les dieux, le ciel et l’enfer, l’âme et son avenir transmigratoire, mais sa littérature est remplie de considérations sur ces sujets. Avec le brahmanisme , le bouddhisme partage le notion de ciel ou, mieux, de cieux dont les moins désincarnés sont régulièrement représentés. Quand le bouddhisme a cessé d’être une religion de moines exclusivement, quand il s’est appellé « Grand Véhicule » (Mahāyāna) et s’est adressé aussi aux laics,, ceux-ci ont prié le Buddha ou ses saints moines (bodhisattva) comme des divinités, pour obtenir leurs faveurs. Ce sont ces derniers qui sont représentés dans des bas-reliefs et peintures devenus très populaires. D’un de ces paradis nommés « Terres pures », on a donné quatre reproductions, et on a commenté plus en détails un taṅgka tibétain montrant le bodhisattva Amitābha ( « Lumière infinie ») trônant dans son paradis « Heureuse Terre » (Sukhavatī) au milieu de ses collègues qui ne sont que des répliques de lui-même et accueillant les humains échappant à la transmigration. [less ▲]

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See detailLes transferts post-mortem : réinterprétation symbolique du lieu d’enterrement dans un contexte de mobilité des populations
Schmitz, Serge ULg

in Espaces et Sociétés (Paris, France) (1999), 99

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery ... [more ▼]

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery choice. It underlines the connections between post-mortem mobility, the different levels of population mobility and culture. [less ▲]

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See detailThe great-grand-daughter design: a simple strategy to increase the power of a grand-daughter design for QTL mapping
Coppieters, Wouter ULg; Kvasz, A.; Arranz, J. J. et al

in Genetical Research (1999), 74

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See detailAlveolar clearance in horses with chronic obstructive pulmonary disease
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, D. H. et al

in American Journal of Veterinary Research (1999), 60

OBJECTIVE: To assess sensitivity of scintigraphic alveolar clearance rate as an indicator of alveolar epithelium damage in horses. ANIMALS: 5 healthy horses (group A) and 5 with chronic obstructive ... [more ▼]

OBJECTIVE: To assess sensitivity of scintigraphic alveolar clearance rate as an indicator of alveolar epithelium damage in horses. ANIMALS: 5 healthy horses (group A) and 5 with chronic obstructive pulmonary disease (COPD; group B). PROCEDURE: Horses underwent clearance rate (k [%/min]) determination. Clearance rate of group-B horses was determined after remission of the disease following 2 months at pasture (remission 1), stabling in a controlled environment (remission 2), and during crisis induced by exposure to moldy hay and straw. Methacholine challenge test was performed at each investigation period to determine nonspecific pulmonary airway hyperresponsiveness. Pulmonary function tests (PFT) also were performed, and cell populations in bronchoalveolar lavage (BAL) fluid were determined on another occasion. RESULTS: Group-B horses had significantly faster mean clearance rate during crisis (k = 4.30+/-0.95%/min), compared with that for remission 1(k = 1.98+/-0.55%/min), which did not differ from the rate in group-A horses (k = 1.95+/-0.33%/min). Despite lack of clinical signs of COPD during remission when stabled in a controlled environment, an intermediate value was found (k = 3.20+/-0.72%/min). CONCLUSIONS: This technique allowed grading of lung damage induced by COPD, whereas use of PFT and determination of BAL fluid cell populations failed to differentiate between remission 1 and remission 2. CLINICAL RELEVANCE: Determination of alveolar clearance rate by use of scintigraphy is a sensitive indicator of lung damage. A modified clearance rate was found despite the lack of clinical and functional changes [less ▲]

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See detailCharacterizations by automorphism groups of some rank 3 buildings - II: A half strongly-transitive locally finite triangle building is a Bruhat-Tits building
Van Maldeghem, H.; Van Steen, Kristel ULg

in Geometriae Dedicata (1999), 74(2), 113-133

We complete the proof of the fact that every locally finite triangle building Delta with a half strongly-transitive automorphism group G (e.g., this happens when Delta is defined via a (B, N)-pair in G ... [more ▼]

We complete the proof of the fact that every locally finite triangle building Delta with a half strongly-transitive automorphism group G (e.g., this happens when Delta is defined via a (B, N)-pair in G) is a Bruhat-Tits building associated with a classical linear group over a locally finite local skewfield. [less ▲]

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See detailInter-laboratory comparison of cytogenetic endpoints for the biomonitoring of radiological workers.
Thierens, H.; Vral, A.; de Ridder, L. et al

in International Journal of Radiation Biology (1999), 75(1), 23-34

PURPOSE: The evaluation of different cytogenetic endpoints of radiation damage for the biomonitoring of contract workers temporarily employed at nuclear power plants. MATERIALS AND METHODS: Blood samples ... [more ▼]

PURPOSE: The evaluation of different cytogenetic endpoints of radiation damage for the biomonitoring of contract workers temporarily employed at nuclear power plants. MATERIALS AND METHODS: Blood samples from six donors were irradiated in vitro with doses ranging from 0.1 to 2Gy 60Co gamma-rays. Compared were a conventional analysis for dicentrics, the conventional micronucleus (MN) assay, the centromere micronucleus assay using p82H and an alphaAllCen pancentromeric probe, and tricolour FISH with chromosome 2, 4 and 8 DNA probes for the scoring of translocations. RESULTS: Agreement in the number of MN between Giemsa-and propidium iodine fluorescence-stained preparations was obtained. The control samples showed higher centromere positivity for the MN after FISH with the p82H probe compared with the alphaAllCen probe. The MN results with both probes showed a slight but systematic increase in the number of centromere-positive MN with dose, indicating that radiation, although principally clastogenic, also has aneuploidogenic properties. The values of the genomic translocation frequency (FG) derived from the observed translocation frequencies were systematically higher than the dicentric yields. Comparing the sensitivity of the different methods with restriction of the scoring time to 1 day for biomonitoring purposes, the centromere micronucleus assay had the lowest dose detection limit (0.1 to 0.2 Gy). CONCLUSION: This study shows that at present only the centromere micronucleus assay can combine high sensitivity with a reasonable scoring time for the biomonitoring of relatively large populations. [less ▲]

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See detailThe Indotriradites dolianitii Morphon, a distinctive group of miospore species from the Lower Carboniferous of Gondwana.
Loboziak; Melo, J.H.G.; Playford, G et al

in Review of Palaeobotany and Palynology (1999), 107

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See detailAnalysing financial returns using regression models based on non-symmetric stable distributions
Lambert, Philippe ULg; Lindsey, James ULg

in Journal of the Royal Statistical Society : Series C (Applied Statistics) (1999), 48

The daily evolution of the price of Abbey National shares over a 10-week period is analysed by using regression models based on possibly non-symmetric stable distributions. These distributions, which are ... [more ▼]

The daily evolution of the price of Abbey National shares over a 10-week period is analysed by using regression models based on possibly non-symmetric stable distributions. These distributions, which are only known through their characteristic function, can be used in practice for interactive modelling of heavy-tailed processes. A regression model for the location parameter is proposed and shown to induce a similar model for the mode. Finally, regression models for the other three parameters of the stable distribution are introduced. The model found to fit best allows the skewness of the distribution, rather than the location or scale parameters, to vary over time. The most likely share return is thus changing over time although the region where most returns are observed is stationary. [less ▲]

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See detailModélisation spatiale de la sélection de l'habitat chez le Blaireau européen (Meles meles) au moyen d'un Système d'Information Géographique.
Vanhalle, L.; Defourny, P.; Dufrêne, Marc ULg

in Cahiers des Réserves Naturelles -Rnob (1999), 13

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See detailThe DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family.
Fanuel, L; Goffin, Colette ULg; Cheggour, A et al

in Biochemical Journal (1999), 341(Pt 1), 147-55

The DmpA (d-aminopeptidase A) protein produced by Ochrobactrum anthropi hydrolyses p-nitroanilide derivatives of glycine and d-alanine more efficiently than that of l-alanine. When regular peptides are ... [more ▼]

The DmpA (d-aminopeptidase A) protein produced by Ochrobactrum anthropi hydrolyses p-nitroanilide derivatives of glycine and d-alanine more efficiently than that of l-alanine. When regular peptides are utilized as substrates, the enzyme behaves as an aminopeptidase with a preference for N-terminal residues in an l configuration, thus exemplifying an interesting case of stereospecificity reversal. The best-hydrolysed substrate is l-Ala-Gly-Gly, but tetra- and penta-peptides are also efficiently hydrolysed. The gene encodes a 375-residue precursor, but the active enzyme contains two polypeptides corresponding to residues 2-249 (alpha-subunit) and 250-375 (beta-subunit) of the precursor. Residues 249 and 250 are a Gly and a Ser respectively, and various substitutions performed by site-directed mutagenesis result in the production of an uncleaved and inactive protein. The N-terminal Ser residue of the beta-subunit is followed by a hydrophobic peptide, which is predicted to form a beta-strand structure. All these properties strongly suggest that DmpA is an N-terminal amidohydrolase. An exploration of the databases highlights the presence of a number of open reading frames encoding related proteins in various bacterial genomes. Thus DmpA is very probably the prototype of an original family of N-terminal hydrolases. [less ▲]

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See detailImplication des propriétés biomécaniques des muscles transformés dans le mécanisme de la cardiomyoplastie
Radermacker, M. A.; Sluse, Francis ULg; Focant, B. et al

in Journal of Cardiology (1999), 9

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See detailComment on "Observation of vortex-lattice melting in YBa2Cu3O7-delta by Seebeck-effect measurements"
Ausloos, Marcel ULg; Bougrine, Hassan ULg; Houssa, M. et al

in Physical Review. B : Condensed Matter (1999), 59(1), 671-673

The findings of Ghamlouch et al. [Phys. Rev. B 54, 9070 (1996)] on the jump in the thermoelectric power of high-T-c superconductors below the critical temperature in the presence of large magnetic fields ... [more ▼]

The findings of Ghamlouch et al. [Phys. Rev. B 54, 9070 (1996)] on the jump in the thermoelectric power of high-T-c superconductors below the critical temperature in the presence of large magnetic fields are discussed. The complicated interplay between the vortex lattice thermodynamic transitions and the transport property percolation transitions raises questions on their similarities, differences, and relationships with respect to the (B,T) phase diagram features and the classical Kosterlitz-Thouless transition. A few comments pertain to the experimental details and others on the relevant role of thermomagnetic transport properties. [S0163-1829(99)04102-8]. [less ▲]

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See detailEffects of Nimesulide and Indometacin on Cox-1 and Cox-2: A Comparative Study
de Leval, X.; Dogné, Jean-Michel ULg; Neven, P. et al

in Journal de Pharmacie de Belgique (1999), 54(3), 89-90

Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have ... [more ▼]

Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin. [less ▲]

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See detailDerived Projective Limits of Topological Abelian Groups
Prosmans, Fabienne ULg

in Journal of Functional Analysis (1999), 162(1), 135-177

We prove that the category of topological Abelian groups is quasi-Abelian. Using results about derived projective limits in quasi-Abelian categories, we study exactness properties of the projective limit ... [more ▼]

We prove that the category of topological Abelian groups is quasi-Abelian. Using results about derived projective limits in quasi-Abelian categories, we study exactness properties of the projective limit functor in the category of topological Abelian groups. [less ▲]

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