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See detailThe influence of cortical perforations and of space filling with peripheral blood on the kinetics of guided bone generation. A comparative histometric study in the rat.
Rompen, Eric ULg; Biewer, Robert; Van Heusden, Alain ULg et al

in Clinical Oral Implants Research (1999), 10(2), 85-94

The aim of the present study was to evaluate the influence of cortical perforations and of peripheral blood addition in guided bone generation beyond the skeletal envelope in rats. A total of 30 isogenic ... [more ▼]

The aim of the present study was to evaluate the influence of cortical perforations and of peripheral blood addition in guided bone generation beyond the skeletal envelope in rats. A total of 30 isogenic adult rats were divided into 3 equal groups. In each rat, two hollow parallelipipedic titanium chambers were placed bilaterally on the calvaria after a periosteal skin flap was raised. While on the right sides (controls) the osseous surface was left intact and the chambers were empty, the cortical bone under the left-side chambers (test sites) was perforated with nine 0.8 mm-diameter holes (group I), or left intact but with the chambers filled with a clot of peripheral blood (group II). In group III, both procedures were combined in the test sites. The healing was assessed at 4, 8 and 16 weeks after surgery by histologic and computer-assisted histometric analysis. The results demonstrated a substantial augmentation of on average 141% (SD 18) of the skull's thickness after 16 weeks in the controls, indicating that a predictable bone formation can be achieved beneath completely occlusive barriers over a non-injured cortical layer. In all test groups, a significantly larger bone augmentation was observed after 16 weeks compared to the control sites 172.8% (SD 41.7) in group I (P < 0.05), 172.0% (SD 18.4) in group II (P < 0.05) and 221.5% (SD 42.3) in group III (P < 0.001), demonstrating that stimulating blood supply and bone forming cells access by cortical perforations and/or blood clot addition enhances de novo bone formation in this experimental model. [less ▲]

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See detailTieleman Jansz. van Braght et la construction anabaptiste du passé
Donneau, Olivier ULg

in Revue d'Histoire Ecclésiastique (1999), 94

In his martyrology (published in 1660), the conservative Dutch Mennonite Tieleman Jansz. van Braght propose an original interpretation of the Christian past. In order to put together a succession of ... [more ▼]

In his martyrology (published in 1660), the conservative Dutch Mennonite Tieleman Jansz. van Braght propose an original interpretation of the Christian past. In order to put together a succession of witnesses, he examines one by one the ancient or medieval spiritual ancestors who, at the time, were claimed by both Catholics and Protestants. Those who seems to have been submitting to the divine principles - such as the practice of adult baptism - are considered as orthodox ; furthermore, if the orthodox suffered for their faith, they were given the title of martyr. Among the chosen ones, we thus have, besides the Anabaptists themselves: the early Christians, the Donatists, the Waldenses and the Hussites. These believers become the members of a dissenting and persecuted Church, which had held its own since the days of the Apostles. This notion conflict with the idea of Reformatio et, a fortiori, with that of Restitutio which is generally ascribed to the Anabaptists of the sixteenth century. [less ▲]

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See detailBooklist 1998
Pirenne, Christophe ULg; Mitsui, Toru

in Popular Music (1999), 18(3), 425-446

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See detailL'etude clinique du mois. L'etude LIPID: "long-term intervention withpravastatin in ischaemic disease".
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 2-3

The LIPID study is a placebo-controlled, double-bind, randomized trial, performed in 9014 patients with coronary heart disease and total cholesterol levels of 155 to 271 mg/dl. After a mean follow-up of 6 ... [more ▼]

The LIPID study is a placebo-controlled, double-bind, randomized trial, performed in 9014 patients with coronary heart disease and total cholesterol levels of 155 to 271 mg/dl. After a mean follow-up of 6.1 years, patients receiving pravastatin (40 mg/day) had significantly (p < 0.001) lower death rate from coronary heart disease (24%), lower overall mortality (22%) and lower incidence of all cardiovascular outcomes (20 to 29% depending on the event). Interestingly enough, the reduction in death from coronary heart disease or nonfatal myocardial infarction was observed whatever the initial cholesterol concentration, and already significant if total cholesterol was < 213 mg/dl and LDL cholesterol was < 135 mg/dl. Thus, in secondary prevention, the favourable effect of the statin on the coronary heart disease outcomes is observed even in case of initial cholesterol levels yet considered as "normal". [less ▲]

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See detailGrowth hormone binding protein (GHBP) during lactation in cows.
Renaville, Robert ULg; Prandi, A.; Massart, Serge et al

in Archivio Veterinario Italiano (1999), 50

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See detailUn réformateur lotharingien de choc : l'abbé Poppon de Stavelot (978-1048)
George, Philippe ULg

in Revue Mabillon (1999)

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See detailThermal Energy Distribution Observed in Electrospray Ionization
Drahos, Laszlo; Heeren, Ron; Collette, Caroline ULg et al

in Journal of Mass Spectrometry [=JMS] (1999), 34

A new method was developped which fits a thermal internal energy distribution to ions formed by electrospray ionization. The molecular ion survival yield was measured and determined by RRKM calculations ... [more ▼]

A new method was developped which fits a thermal internal energy distribution to ions formed by electrospray ionization. The molecular ion survival yield was measured and determined by RRKM calculations as a function of temperature. The "characteristic" temperature was determined when the calculated and measured molecular survival yields were equal. The validity of the method was also checked performing blackbody infrared radiation and on-resonance excitation experiments on a Fourier transform ion cyclotron resonance instrument with benzylpyridine salts and leucine enkephalin. [less ▲]

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See detailL'etude clinique du mois. Etudes cliniques a long terme (1-2 ans) avec l'orlistat, nouveau medicament pour le traitement de l'obesite.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(8), 707-9

Orlistat (Xenical), whose original mechanism of action consists of the selective inhibition of gastrointestinal lipases, has been recently commercialized for the treatment of obesity. Despite its recent ... [more ▼]

Orlistat (Xenical), whose original mechanism of action consists of the selective inhibition of gastrointestinal lipases, has been recently commercialized for the treatment of obesity. Despite its recent launch and when compared to common anorectic agents, it has been much better evaluated in long-term trials carried out according to the rules of Good Clinical Practice. We will summarize the four recently published randomized, placebo-controlled, double-blind clinical trials lasting up to 1 to 2 years and evaluating the effects of orlistat 3 x 120 mg/day in obese patients (BMI > or = 28 kg/m2). [less ▲]

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See detailNe VI spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in Journal of the Optical Society of America. B, Optical Physics (1999), 16

On the basis of all the available observations of the Ne VI spectrum, particularly the new beam-foil spectra obtained at Liège University, approximately 50 new line assignments are proposed and ... [more ▼]

On the basis of all the available observations of the Ne VI spectrum, particularly the new beam-foil spectra obtained at Liège University, approximately 50 new line assignments are proposed and approximately 30 new energy levels are determined in Ne VI. All known energy levels have been improved, and a new value is proposed for the ionization potential. The new line identifications are supported by Hartree–Fock calculations combined with parametric fitting of energies and transition rates. [less ▲]

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See detailL’utilisation du fluor dans la thérapeutique de l’ostéoporose
Reginster, Jean-Yves ULg

in Synoviale (1999), 81

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See detailLes travailleurs migrants à travers la presse quotidienne de Shenzhen (1993-1999)
Florence, Eric ULg

in Techniques, Territoires et Société (1999), Vol. 36(n° 1), 285-293

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See detailLa sécheresse buccale en gériatrie
Hockers, Thierry ULg; Lamy, Marc ULg

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (1999), 54(1), 41-50

Dry mouth is usual in geriatrics. It doesn't seem a age related change of salivary gland tissues, but as often as not, it results from the use of some drugs. Seventy percents of institutionalised elderly ... [more ▼]

Dry mouth is usual in geriatrics. It doesn't seem a age related change of salivary gland tissues, but as often as not, it results from the use of some drugs. Seventy percents of institutionalised elderly population consummate these medications with buccal significance. This publication tries to summarize the means of diagnosis and the possibilities to treat this pathology. [less ▲]

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See detailUnimolecular reaction dynamics from kinetic energy release distributions.IV. Dissociation of the Pyridine ion.
Urbain, P.; Leyh, Bernard ULg; Remacle, Françoise ULg

in International Journal of Mass Spectrometry and Ion Processes (1999), 185-187

The kinetic energy release distribution (KERD) for the dissociation of the Pyridine ion into C4H4++HCN in the microsecond time window has been experimentally determined and theoretically analyzed by the ... [more ▼]

The kinetic energy release distribution (KERD) for the dissociation of the Pyridine ion into C4H4++HCN in the microsecond time window has been experimentally determined and theoretically analyzed by the maximum entropy method. Less energy is channeled into the reaction coordinate than the statistical estimate because of the action of the "moentum gap law". The larger the value of the relative translational momentum of the fragments, the less efficient the exploration of phase space. the fraction of phase space efficiently sampled is estimated to be of the order of 75%. [less ▲]

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See detailHistidine modification and mutagenesis point to the involvement of a large conformational change in the mechanism of action of phage lambda lysozyme
Evrard, Christine ULg; Fastrez, Jacques; Soumillion, Patrice

in FEBS Letters (1999), 460

Phage lambda lysozyme is structurally related to other known lysozymes but its mechanism of action is different from the classical lysozyme mechanism, acting as a transglycosidase rather than a hydrolase ... [more ▼]

Phage lambda lysozyme is structurally related to other known lysozymes but its mechanism of action is different from the classical lysozyme mechanism, acting as a transglycosidase rather than a hydrolase. As two conformations have been revealed by the crystal structure, we investigated the effect of mutating and modifying a histidine located near to or far from the active site in the respective closed and open conformations. Whereas its asparagine mutation has little or no effect on activity, its N-carbethoxylation inactivates the enzyme. This provide further evidence for the involvement of the closed conformation and for the need of conformational mobility in lambda lysozyme function. [less ▲]

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See detailLe risque cardio-vasculaire lie a l'hypercholesterolemie: d'un continuum a la notion de normalite, de seuil d'intervention et d'objectif therapeutique.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 17-21

There appears to be a continuum between the cardiovascular risk and the level of blood cholesterol, which hinders the definition of normal values, intervention threshold and therapeutic goals. The more ... [more ▼]

There appears to be a continuum between the cardiovascular risk and the level of blood cholesterol, which hinders the definition of normal values, intervention threshold and therapeutic goals. The more and more convincing evidences provided by the "Evidence-Based Medicine" should be confronted to the pharmaco-economical constraints in order to first focus the essential of the efforts and resources on the target population with the highest risk. Unfortunately, the therapeutic strategy concerns a rather high percentage of the population of industrialized countries. [less ▲]

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See detailObzor verkhnego paleolita Moldavii
Otte, Marcel ULg; Noiret, Pierre ULg; López Bayón, Ignacio

in Stratum Plus (1999), 1

The existing in Moldova Aurignacian industries of the lamellar type are represented by the stone collections of two kinds: with leaf-shaped points and backed points with a concave edge. Together with this ... [more ▼]

The existing in Moldova Aurignacian industries of the lamellar type are represented by the stone collections of two kinds: with leaf-shaped points and backed points with a concave edge. Together with this the Corpach IV industry which includes backed points (segments) must have been related to Gravette. Other industries should not be considered separately and apparently can be grouped under the title "industries de type Paléolithique supérieur ancien à pointes foliacées". They are supposed to spring from the Middle Palaeolithic industries with leaf-shaped pieces (from Micoquian of Central Europe), that were further developed in the Aurignacian direction. If the Aurignacian of Moldova has evidently a foreign origin, then the Gravette traditions go back to some related centers. It is reflected in the compatibilty of backed pieces and leaf-shaped points in one and the same industry, dated back to the early stage of the Upper Palaeolithic. It is clearly seen in the collections of lower layers of Molodova V where homogeneousness of the complex is evident starting with the tenth layer. The appearance of some new types of tools (for instance, shouldered points) in the upper layers of this site does not fail the general stability and the cultural originality of the industry. [less ▲]

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See detailL'anorexie mentale, une maladie grave specifique de la femme jeune.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(4), 255-61

Anorexia nervosa is characterized by a triad comprising anorexia, weight loss, and amenorrhoea. It is typically present in adolescent or young adult women and its prevalence appears to increase in our ... [more ▼]

Anorexia nervosa is characterized by a triad comprising anorexia, weight loss, and amenorrhoea. It is typically present in adolescent or young adult women and its prevalence appears to increase in our society. Eating disorders may lead to cachexia and various severe complications. This disease, which appears to be associated to a particular psychological background, is triggered by conflictual relationships, usually within the family. The anorectic patient should be carefully evaluated, as soon as possible, from a somatic, dietetic and psychological point of view. A specific therapeutic approach should be rapidly proposed in a specialized centre, if possible by a multidisciplinary team. The treatment is most often difficult and of long duration. Prognosis remains uncertain in most cases, especially when appropriate care is delayed. [less ▲]

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See detailThe first successful crystallization of a prokaryotic extremely thermophilic outer surface layer glycoprotein
Evrard, Christine ULg; Declercq, Jean-Paul; Debaerdemaeker, Tony et al

in Zeitschrift für Kristallographie (1999), 214

Methanothermus fervidus belongs to the group of hyperthermophilic Archaea. The Archaea comprise organisms that live under environmental extremes. like high temperature, low pH value or high salt ... [more ▼]

Methanothermus fervidus belongs to the group of hyperthermophilic Archaea. The Archaea comprise organisms that live under environmental extremes. like high temperature, low pH value or high salt concentration. The outer surface of the pseudomurein sacculi of the cells of Methanothermus fervidus is covered by glycoprotein subunits (S-Iayer) directly exposed to the extreme environment. The elucidation of the crystal structure of this surface glycoprotein may provide important information on the survival strategies of these unusual micro-organisms. Before our investigations neither three-dimensional crystals have been obtained nor X-ray analyses were performed. Only electron microscopic and computer image enhancement techniques have been applied to obtain structural information from crystalline two-dimensional S-layer sheets. We describe here the successful crystallization of this surface glycoprotein under microgravity conditions. [less ▲]

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See detailLe quiproquo de la consommation medicale de la femme.
Gillet, Pierre ULg; Tellier, V.

in Revue Médicale de Liège (1999), 54(4), 214-23

By analysing three different Belgian databases, we could demonstrate that whereas women subjectively declare a higher number of diseases, a worse functional state and a higher trend to use medical ... [more ▼]

By analysing three different Belgian databases, we could demonstrate that whereas women subjectively declare a higher number of diseases, a worse functional state and a higher trend to use medical resources, they are, from an objective point of view, less frequently hospitalized and cause a lower cost, at certain ages, for the Social Security. [less ▲]

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See detailAcute respiratory distress syndrome: 30 years later
Lesur, O.; Berthiaume, Y.; Blaise, G. et al

in Canadian Respiratory Journal : Journal of the Canadian Thoracic Society (1999), 6(1), 71-86

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See detailInsulin lispro (Humalog) in the treatment of diabetes mellitus: overview of belgian clinical data from global studies.
Bex, M.; Buysschaert, M.; De Leeuw, I. et al

in Acta Clinica Belgica (1999), 54(5), 241-5

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See detailAdvocado/soybean unsaponifiable mixture increased high molecular weight proteoglycans synthesis by human articular chondrocytes
Henrotin, Yves ULg; Labasse, A; Guillou, B et al

in Annals of Rheumatoid Arthritis (1999), 230

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See detailLoi de protection des malades mentaux. La mise en observation psychiatrqiue
Boxho, Philippe ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1999), 21

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See detailNonresponsive Generalized Bacterial Infection Associated with Systemic Lupus Erythematosus in a Beauceron
Clercx, Cécile ULg; Mc Entee, Kathleen ULg; Gilbert, S. et al

in Journal of the American Animal Hospital Association (1999), 35(3, May-Jun), 220222224-8

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular ... [more ▼]

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies. [less ▲]

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See detailMaximal Ventilation Assessment in Healthy Calves
Bureau, Fabrice ULg; Coghe, J.; Uystepruyst, C. H. et al

in Veterinary Journal (1999), 157(3), 309-314

In order to define a reliable method for estimating maximal ventilation in cattle, 12 healthy calves underwent a rebreathing trial and injections of increasing doses of lobeline, a respiratory analeptic ... [more ▼]

In order to define a reliable method for estimating maximal ventilation in cattle, 12 healthy calves underwent a rebreathing trial and injections of increasing doses of lobeline, a respiratory analeptic. The effects of these tests on the main ventilatory parameters (tidal volume, VT; respiratory frequency, fR and minute volume,.VE) recorded during the 15 s of maximal response were studied and compared. The sharp rise in.VE(4.8 times higher than the resting value) observed during the rebreathing trial was mainly due to an increase in VT. This rise in ventilation was the highest ever reported in calves. Lobeline dose-dependently enhanced ventilation up to a threshold dose of 0.25 mg/kg, which always produced a maximal response. This maximal response (3.7 times higher than the resting value), reflecting both an increase in fR and VT, was reproducible at an interval of 12 h and was highly correlated with that observed during the rebreathing trial (R = 0.98, P< 0.001). These results suggest that: (1) rebreathing trial is a reliable method to induce and measure maximal ventilation in calves; and (2) lobeline administration (0.25 mg/kg) is a reliable means of accurately estimating this variable. Lobeline administration, unlike the rebreathing trial, is safe and easy to standardize, and the test therefore seems to be the preferred way of studying maximal ventilation in calves. [less ▲]

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See detailP300 event-related potential and serotonin-1A activity in depression.
Hansenne, Michel ULg; Ansseau, Marc ULg

in European Psychiatry (1999), 14(3), 143-7

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.40, P = 0.007 at Cz; r = -0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude. [less ▲]

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See detailWestward propagation of the North Anatolian fault into the northern Aegean: Timing and kinematics
Armijo, R.; Meyer, B.; Hubert, Aurelia ULg et al

in Geology (1999), 27

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the ... [more ▼]

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the finite displacement after, the passage of the propagating tip of the fault. The accuracy of the observations is due to interplay between deformation and the sea-level changes in the Mediterranean (the well-known Messinian regression followed by the Pliocene transgres- sion). The long-term kinematics around the Sea of Marmara pull-apart (total displacement of about 85 km over the past 5 m.y.) is similar to the present-day kinematics deduced from space geodesy. At a larger scale, westward propagation of the North Anatolian fault over nearly 2000 km in the past 10 m.y. appears to be associated with strain recovery, suggesting that the continental lithosphere retains long-term elasticity. [less ▲]

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See detailAquaporin-4 water channel plays a role in the pathogenesis of cerebral edema in fulminant hepatic failure
Margulies, J. E.; Thompson, R. C.; Wycoff, K. et al

in Surgical Forum (1999), 46

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See detailLa loi du 10 juin 1998 relative à la prescription de l'action civile née d'une infraction
Jacobs, Ann ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detailAnalysis of Scintigraphical Lung Images before and after Treatment of Horses Suffering from Chronic Pulmonary Disease
Votion, Dominique ULg; Ghafir, Y.; Vandenput, Sandrina ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1999), 144(9), 232-236

Scintigraphical analysis of the ratio of inhalation (I) to perfusion (Q) was designed to determine whether chronic pulmonary disease in horses induced mismatches in I/Q and to assess whether medical ... [more ▼]

Scintigraphical analysis of the ratio of inhalation (I) to perfusion (Q) was designed to determine whether chronic pulmonary disease in horses induced mismatches in I/Q and to assess whether medical treatment would restore an I/Q distribution pattern identical to that of control horses. In addition, the results of the I/Q analysis were correlated with the alveolar-arterial PO2 difference (AaDO2). The I/Q matching found in a group of control horses was compared with the I/Q analysis of a group of diseased horses before and after their clinical signs had been treated. The analysis indicated that there was mismatching between I and Q before they were treated. The treatment improved the diseased horses, pulmonary function but there was still heterogeneity in the I/Q distribution after they had been treated. The I/Q analysis parameters were well correlated with the ratio of ventilation (VA) and pulmonary blood flow (Q), evaluated by the determination of AaDO2 [less ▲]

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See detailFibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review.
VAN DAMME, Hendrik ULg; SakalihasanN, Natzi ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1999), 99(4), 163-8

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two ... [more ▼]

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two suffered from a minor stroke, four had non-focalized ischemic cerebral symptoms and two were asymptomatic. At angiography, all patients showed a typical image of "string of beads". Seven patients were operated on. Six had endoluminal graduated dilatation, with rigid dilators up to 4.5 mm, associated with thrombendarterectomy of the bifurcation in three and to correction of a kink in one case. In one case a venous interposition graft was done to exclude a saccular microaneurysm of the dysplasic internal carotid artery. In another case, backflow was insufficient after endoluminal dilatation, and a long venous patch allowed to restitute a normal vascular lumen. There was neither postoperative mortality nor stroke. Six patients, asymptomatic or with non focalized symptoms, were treated medically. During a mean follow-up of 47 months, only one of the 13 patients developed a transient ischemic attack; the patient had not been operated on and received only medical treatment. Prevalence, etiopathology, diagnosis and management of fibromuscular dysplasia of the internal carotid artery are discussed. Fibromuscular dysplasia is a rare cause of cerebral ischemia. For asymptomatic lesions, a conservative approach seems appropriate. Surgery is only to be considered for symptomatic lesions. Surgical graduated endoluminal dilatation, where necessary combined with standard endarterectomy of the carotid bifurcation, is a safe, efficient and durable operation. Some complex cases of fibromuscular dysplasia may necessitate patch insertion or excision and graft interposition. [less ▲]

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See detailThe use of different dual X-ray absorptiometry brands in a multicenter clinical trial
Slosman, DO; Provedini, DM; Meunier, PJ et al

in Journal of Clinical Densitometry : The Official Journal of the International Society for Clinical Densitometry (1999), 2

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See detail3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry
De Tullio, Pascal ULg; Khelili, S.; Ouedraogo, R. et al

in Pharmacy and Pharmacology Communications (1999), 5

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See detailHyperplasie bénigne de la prostate
Bonnet, Pierre ULg

in La revue de Médecine générale (1999), (161), 120-129

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See detailPutrescine metabolism in a fully habituated nonorganogenic sugar beet callus and its relationship with growth
Kevers, Claire ULg; Bisbis, Badia; Faivre-Rampant, Odile et al

in Journal of Plant Physiology (1999), 154(4), 503-508

A fully-habituated and nonorganogenic (HNO) sugar beet callus was previously shown to overproduce polyamines, as compared with a normal (N) auxin- and cytokinin-dependent callus of the same strain ... [more ▼]

A fully-habituated and nonorganogenic (HNO) sugar beet callus was previously shown to overproduce polyamines, as compared with a normal (N) auxin- and cytokinin-dependent callus of the same strain. Because relationships were established between polyamine levels and metabolism with different growth and development processes, some key enzymes in the metabolic pathways of polyamines were investigated in the HNO callus, and their involvement in growth appraised. Putrescine was found to be the major free and conjugated polyamine in the HNO callus. It was biosynthesised preferentially via ornithine and ornithine decarboxylase (ODC), which is in agreement with the surplus of synthesised ornithine. Diamine (DAO) and polyamine (PAO)-oxidase activities were also highest in the HNO callus, as compared with the normal, with DAO being the more active. Transglutaminase activities (+/- Ca) were also higher in HNO than in normal callus. Addition of different polyamines or of inhibitors of their biosynthesis to the culture medium of the HNO callus modified the level of endogenous polyamines and affected callus growth. The results thus pointed out a higher polyamine metabolism, particularly of putrescine, in the actively growing auxin- and cytokinin-independent callus than in the normal one. They also provided evidence for the sensitivity of a habituated tissue type towards this class of growth regulators. [less ▲]

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See detailPMSG et production d'anticorps : relation avec la productivité des lapines
Theau-Clément, M.; Lebas, F.; Drion, Pierre ULg et al

in Cuniculture (1999), 26(3), 123-126

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See detailDevelopment of a monoclonal antibody-based sandwich ELISA for the détection of bovine enteropathogenic and enterohaemorrhagic strains of Escherichia coli O26
Kerr, P.; China, B.; Mainil, Jacques ULg et al

in Clinical and Diagnostic Laboratory Immunology (1999), 6

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See detailLa maîtrise de son corps par la personne
Genicot, Gilles ULg; Leleu, Yves-Henri ULg

in Journal des Tribunaux (1999)

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See detailFauna vs flora contribution to the leaf epiphytes biomass in a Posidonia oceanica seagrass bed (Revellata Bay, Corsica).
Lepoint, Gilles ULg; Havelange, Stéphane; Gobert, Sylvie ULg et al

in Hydrobiologia (1999), 394

The epiphyte biomass of Posidonia oceanica (L.) Delile leaves is mainly related to the substrate leaf availability. It decreases with increasing depth and increases from winter to summer, following the ... [more ▼]

The epiphyte biomass of Posidonia oceanica (L.) Delile leaves is mainly related to the substrate leaf availability. It decreases with increasing depth and increases from winter to summer, following the leaf biomass changes. In Revellata Bay (Gulf of Calvi, Corsica), at shallow depth (10m in this study) where photophilous algae grow, the fixed epifauna biomass accounts for about one third of leaf epiphytes biomass. At deeper depths in the Revellata Bay (20 and 30m), where shade-tolerant algae are dominant among epiflora, epifauna may account for more than half the leaf epiphytes biomass. [less ▲]

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See detailL'abus de prescription des substances soporifiques, stupéfiantes ou psychotropes
Boxho, Philippe ULg

in Revue Médicale de Liège (1999), 54

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See detailA locus for febrile seizures (FEB3) maps to chromosome 2q23-24.
Peiffer, A.; Thompson, J.; Charlier, Carole ULg et al

in Annals of Neurology (1999), 46(4), 671-8

Febrile seizures are the most common form of childhood seizures, occurring in 2% to 5% of North American children. We report a large Utah family with 21 members affected by febrile seizures inherited as ... [more ▼]

Febrile seizures are the most common form of childhood seizures, occurring in 2% to 5% of North American children. We report a large Utah family with 21 members affected by febrile seizures inherited as an autosomal dominant trait. All had generalized tonic-clonic seizures with onset associated with fever, consistent with the consensus febrile seizure phenotype, and none had febrile seizures beyond 6 years of age. Eighteen affected individuals had recurrent febrile seizures. Eight individuals developed afebrile seizures between ages 5 and 13 years. Afebrile seizures consisted of generalized tonic-clonic, generalized tonic, generalized atonic, simple partial, and partial complex seizure types and were associated with abnormal electroencephalographic findings in 5 individuals, all of whom were intellectually normal. We undertook linkage analysis in this family, defining the disease phenotype as febrile seizures alone. Linkage analysis in epilepsy candidate gene/loci regions failed to show evidence for linkage to febrile seizures. However, a genomewide scan and subsequent fine mapping revealed significant evidence for a new febrile seizure locus (FEB3) on chromosome 2q23-24 with linkage to the marker D2S2330 (LOD score 8.08 at theta = 0.001). Haplotype analysis defined a critical 10-cM region between markers D2S141 and D2S2345 that contains the FEB3 locus. [less ▲]

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See detailUne tâche pigmentée suspecte
Vanhooteghem, Olivier ULg; Richert, Bertrand ULg; de LA BRASSINNE, Michel ULg

in Revue de Médecine Générale [=RMG] (1999), 166

What is your diagnosis for this periungual coloured spot of the thumb ?

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See detailbeta-carboline glucoalkaloids from Strychnos mellodora
Brandt, V.; Tits, Monique ULg; Geerlings, A. et al

in Phytochemistry (1999), 51(8), 1171-1176

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See detailErythropoietin and platelet production.
Beguin, Yves ULg

in Haematologica (1999), 84(6), 541-7

BACKGROUND AND OBJECTIVE: Erythropoietin (Epo) is the primary growth factor for the red cell lineage but treatment with recombinant human Epo (rHuEpo) has been shown to increase platelet counts. In ... [more ▼]

BACKGROUND AND OBJECTIVE: Erythropoietin (Epo) is the primary growth factor for the red cell lineage but treatment with recombinant human Epo (rHuEpo) has been shown to increase platelet counts. In several animal species treatment with rHuEpo stimulated platelet production, but platelet counts tended to normalize after 1-2 weeks and large, chronic doses even caused thrombocytopenia. This paper aims to review the evidence about the effects of Epo on megakaryopoiesis. INFORMATION SOURCES: I examined the literature published in journals covered by Medline(R)a concerning the effects of Epo, hypoxia and iron deficiency on megakaryopoiesis and platelets. The reference list of each article was reviewed to try to identify further contributions. STATE OF THE ART: In vivo data have shown that moderate Epo stimulation, i.e. that produced by standard doses of rHuEpo, short-term hypoxia or moderate iron deficiency, causes a moderate elevation of platelet counts, whereas intense Epo stimulation, as produced by high doses of rHuEpo, prolonged hypoxia or severe iron deficiency, causes some degree of thrombocytopenia. In the latter case, there appears to be a diphasic response to Epo, the initial positive response (a stimulation of platelet production) being followed by thrombocytopenia. Contrarily to the thrombocytopenia due to increased platelet destruction induced by other growth factors, Epo-induced thrombocytopenia is the result of an inhibition of platelet production. CONCLUSION AND PERSPECTIVE: Stem-cell competition between erythroid and platelet precursors appears to be the cause of these phenomena in situations of prolonged, intense stimulation by Epo. In vitro data support the existence of a common erythrocytic and megakaryocytic precursor. It remains to be determined whether these effects of rHuEpo are a result of the dose itself or of the magnitude of the erythropoietic effect of that dose. It is not known whether a lower dose given in a patient with decreased marrow function would bring about the same biological effects as those induced by high doses of rHuEpo in the presence of a normal marrow function. Caution should be exercised before using high doses of hematopoietic growth factors. [less ▲]

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See detailAtteintes physiopathologiques liees a la circulation extracorporelle. Pathogenies et modes de prevention
Defraigne, Jean-Olivier ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154(10-12), 381-91392-5

During heart surgery, several humoral cascades (coagulation, complement, kallicrein-kinin, cytokines, fibrinolysis) and several cell systems (platelets, neutrophils, endothelial cells, ...) are activated ... [more ▼]

During heart surgery, several humoral cascades (coagulation, complement, kallicrein-kinin, cytokines, fibrinolysis) and several cell systems (platelets, neutrophils, endothelial cells, ...) are activated. Numerous contributing factors have been reported: blood contact with foreign surfaces of the extracorporeal circuits, blood-air interface, lung and myocardial ischemia-reperfusion after unclamping, hypothermia, shear stresses, ... A post-perfusion syndrome may develop which include miscellaneous symptoms: coagulation disturbances and bleeding, neurological alterations, inflammatory syndrome, and, in extreme cases, multisystemic organ failure. Even if the present mortality of cardiac surgery is low, several approaches have been proposed to reduce such activations. They are based on changing in the circuit design, or in the composition of the luminal surfaces of the tubing and oxygenator, on improvement of the operative technique, and on modifications of the perfusion technique. Pharmacological agents are also used (anti-inflammatory drugs, corticoids, serine proteases inhibitor (aprotinin, ...). Nevertheless, the development of more biocompatible surfaces seems a promising goal. [less ▲]

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See detailOn the analysis of steel structures made of thin-walled members
Degée, Hervé ULg

in Acta Polytechnica (1999), 39(5), 7-14

A first part of this paper consists in a review of the different existing methods, allowing to study the behaviour of members for which it is necessary to account for the deformability of the cross ... [more ▼]

A first part of this paper consists in a review of the different existing methods, allowing to study the behaviour of members for which it is necessary to account for the deformability of the cross section. A particular attention is paid to the capacity of each method to be used for the global analysis of a complete structure. A second part of the paper presents bases for the adaptation of a beam finite element so as to be able to account for the deformability of the profile crosse section. [less ▲]

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See detail"CAPCIL". Adaptation posologique des traitements par aminoglycosides
Gougnard, Thierry; Charlier, Corinne ULg; Plomteux, Guy ULg

in Acta Clinica Belgica. Supplementum (1999), 1

The objectives of the therapeutic drug monitoring are to assume the efficacy and inocuity of a medical treatment and the patient's observance. The administration of a drug to a patient is not always ... [more ▼]

The objectives of the therapeutic drug monitoring are to assume the efficacy and inocuity of a medical treatment and the patient's observance. The administration of a drug to a patient is not always performed in the same conditions and therefore treatment has to be adapted. When necessary, this one is very often based on empiric or very approximative notions and, more seldom, on results of plasmatic concentrations of the drug. The CAPCIL program allows the possibility to objectivate the medical decision and adapt the posology on the basis of two kinetic parameters: the biological half-life and the distribution volume. Indeed, most of pharmacokinetics modifications (drug interactions, diseases, ...) are affecting the two parameters. With basic informations so as height and weight, posology, treatment objectives and peak/trough plasmatic concentrations of the drug, the program is proposing several posology adaptation schemes. The example of a once-a-day administration of amikacin is discussed. [less ▲]

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See detailBibliographie concernant la loi de protection des malades mentaux
Boxho, Philippe ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1999), 21

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See detailLa mesure du courant critique des matériaux supraconducteurs à haute température critique
Vanderbemden, Philippe ULg

in Bulletin de l'Association des Ingénieurs sortis de l'Université de Liège (AILg) (1999), 6

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See detailImpairment of neuromuscular transmission in a subgroup of migraine patients
Ambrosini, Anna; MAERTENS DE NOORDHOUT, Alain ULg; Alagona, Giovanna et al

in Neuroscience Letters (1999), 276(3), 201-3

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura ... [more ▼]

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholine release. Using single fiber EMG recordings we were able to demonstrate subclinical abnormalities of neuromuscular transmission in a subgroup of patients suffering from migraine with aura. This could be related to genetic abnormalities of P/Q Ca2+ channels in certain patients suffering from migraine with aura, which needs to be explored by proper genetic analyses. [less ▲]

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See detailLow activity of amine-oxidases and accumulation of conjugated polyamines in disfavour of organogenic programs in Chrysanthemum leaf disc explants
Aribaud, Marcel; Kevers, Claire ULg; Martin-Tanguy, Josette et al

in Plant Cell, Tissue & Organ Culture (1999), 55(2), 85-94

Foliar discs (8 mm diameter) from expanding leaves of the middle part of vegetative shoots of Chrysanthemum morifolium Ramat raised in vitro were induced to form directly on specific media in vitro either ... [more ▼]

Foliar discs (8 mm diameter) from expanding leaves of the middle part of vegetative shoots of Chrysanthemum morifolium Ramat raised in vitro were induced to form directly on specific media in vitro either roots or vegetative buds, or callus. The budding programme, on its specific medium, was deviated to callus formation by the addition of 2 mM beta-OH-E (beta-OH-ethyldrazine, an inhibitor of diamine oxidase). Conversely vegetative buds instead of callus were formed on the callus medium in the presence of 2 mM DFMO (difluoromethylornithine, an inhibitor of ornithine decarboxylase). Callus formation was characterized by high accumulation of free and particularly conjugated polyamines (PA), very low or undetectable activities of diamine- and polyamine oxidases, and transglutaminase. DFMO-deviation of callus initiation in favour of bud formation lowered the accumulation of PA and increased the activity of amine-oxidases. The high catabolism of PA in the organogenic (rooting, budding) programs was questioned as to its role in developmental processes. [less ▲]

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See detailActualisation de la prise en charge de l'hypertension artérielle
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), (54), 683-687

The International Society of Hypertension and the World Heath Organisation have recently published new guidelines for the management of hypertension. Epidemiologic studies have shown that management of ... [more ▼]

The International Society of Hypertension and the World Heath Organisation have recently published new guidelines for the management of hypertension. Epidemiologic studies have shown that management of hypertension still remains insatisfactory. The aim of the treatment is to reduce the cardiovascular morbidity and mortality by normalizing blood pressure. The target blood pressure under treatment must be less than 140/90 mmHg, and even lower for diabetic or chronic renal failure patients. In parallel, all cardio-vascular risk factors have to be corrected to decrease the global cardio-vascular risk. [less ▲]

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See detailAdvective excess Ba transport as shown from sediment and trap geochemical signatures
Fagel, Nathalie ULg; André, Luc; Dehairs, Frank

in Geochimica et Cosmochimica Acta (1999), 63(16), 2353-2367

We report the results of a geochemical study of sediment and trap material. Major and trace elements (Zr, Ba, rare earth elements, and Th) were analyzed on bulk sedimentary material collected along the NE ... [more ▼]

We report the results of a geochemical study of sediment and trap material. Major and trace elements (Zr, Ba, rare earth elements, and Th) were analyzed on bulk sedimentary material collected along the NE Atlantic margin. Our aim is to test the widespread use of Ba-barite as a proxy for paleoproductivity in a continental margin area. This environment is of great interest because atmospheric-oceanic exchanges are important. In sediments, the geochemical signatures remain close to an upper crust reference, with flat shale-normalized rare earth elements patterns and constant elementary ratios. The calculated biogenic fraction of Ba or excess Pa (20-45%) remains lower than the excess Ba record in trap material (80-99%). The evolution of the geochemical signature along the margin reflects variable dilution of a detrital Post Archean Australian Shale-like component by a biogenic carbonaceous seawater-derived component. The trap material displays a wide range of variation in its trace element content (e.g., Ba similar to 150-3000 ppm, Zr similar to 2-100 ppm), except for the abyssal site, which is characterized by constant signature. In the two other sites, all of the trace element contents increase with water depth and present pronounced seasonal changes at each sampled water depth. The amount of excess Ba also increases in the deepest traps, and its evolution throughout the year mimics the change of the other analyzed trace elements. In contrast, its relationships with particulate organic carbon are not obvious. In term of fluxes, two periods of enhanced excess Ba fluxes are observed: (1) excess Pa flux increases with the detrital-like elements like Th especially during winter, and (2) excess Pa flux is enhanced without any change for the other trace elements during spring. To explain the first case, a supply through lateral advection is proposed. Such transient input of significant excess Ba flux will have a great impact on the yearly averaged estimation of the export production. Indeed, only the second case reflects a bloom in the biological productivity of the water column and must be taken into account in a mean calculation of the export production. Finally, a normalization of the excess Ba by detrital-like element like Th will help to discriminate between a real increase of the excess Ba due to local productivity change (high excess Ba and high excess Ba/Th ratio greater than or equal to 10,000) and any input due to advection process (high excess Ba but low excess Ba/Th ratio < 2000). Copyright (C) 1999 Elsevier Science Ltd. [less ▲]

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See detailLa notion d'incapacité de travail personnel
Boxho, Philippe ULg

in Revue de Droit Pénal et de Criminologie (1999), 1

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See detailBiochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the alpha-methyl-L-tryptophan method.
Gharib, Abdallah; Balende, Cédar; Sarda, Nicole et al

in Journal of Neurochemistry (1999), 72(6), 2593-600

Biochemical approaches were used in freely moving rats to determine, under steady-state conditions, the brain/arterial plasma partition coefficients of L-tryptophan and alpha-[3H]methyl-L-tryptophan, from ... [more ▼]

Biochemical approaches were used in freely moving rats to determine, under steady-state conditions, the brain/arterial plasma partition coefficients of L-tryptophan and alpha-[3H]methyl-L-tryptophan, from which the lumped constant for the alpha-methyl-L-tryptophan method of estimating the rate of brain serotonin synthesis is calculated. The lumped constants were significantly different in the various structures examined: 0.149 +/- 0.003 in the raphe dorsalis, 0.103 +/- 0.002 in the raphe centralis, 0.087 +/- 0.003 in the reticular formation, and 0.62 +/- 0.08 in the pineal gland. From these data we proposed a two-compartment model to calculate the rate of serotonin synthesis by quantitative autoradiography using a three-time point experiment. Rates of synthesis for the raphe dorsalis and the reticular formation (620 +/- 57 and 80 +/- 35 pmol/g of tissue/min, respectively) were similar to those measured simultaneously by biochemical means, but rates were 50% higher for the raphe centralis (568 +/- 90 vs. 381 +/- 31 pmol/g of tissue/min). The lack of dynamic equilibrium of the tracer between plasma and tissue pools may explain the discrepancy between the two methods. Our findings did not confirm previous data, indicating that the application of the autoradiographic method to measure the rate of brain serotonin synthesis using alpha-methyl-L-tryptophan as tracer has limitations. [less ▲]

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See detailThree-dimensional Kinetic Energy Distributions of Ions using a Retarding Potential Analyser. Analysis of Discimination Effects by Ion Trajectory Simulations.
Hoxha, A.; Leyh, Bernard ULg; Locht, Robert ULg

in Rapid Communications in Mass Spectrometry : RCM (1999), 13

This paper presents a method of extracting three-dimensional kinetic energy distributions from retarding potential curves, suitable for analysing low kinetic energy releases. Trajectory calculations were ... [more ▼]

This paper presents a method of extracting three-dimensional kinetic energy distributions from retarding potential curves, suitable for analysing low kinetic energy releases. Trajectory calculations were performed which led to an analytical function correcting for the influence of discrimination against ions with velocity components perpendicular to the retarding field direction. The analysis of the thermal kinetic energy distribution of molecular vinyl bromide ions confirms the computed correcting factor. [less ▲]

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See detailAberglauben, Krankheit und das Böse. Exorzismus und Teufelsglaube im 18. und 19. Jahrhundert
Van den Bossche, Benoît ULg; Freytag, Niels

in Rheinisch-westfälische Zeitschrift für Volkskunde (1999), XLIV

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See detailPsychology facing the challenges of the third millenium
Richelle, Marc ULg

in Revista Portuguesa de Psicologia (1999), 33

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See detailFluoride for the treatment of osteoporosis
Reginster, Jean-Yves ULg

in Annals of Internal Medicine (1999), 130

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See detailTwist number statistics as an additional measure of habitat perimeter irregularity.
Bogaert, Jan ULg; Van Hecke, P; Moermans, R et al

in Environmental and Ecological Statistics (1999), 6(3), 275-290

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See detailAquatic bryophytes for a spatio-temporal monitoring of the water pollution of the rivers Meuse and Sambre (Belgium)
Vanderpoorten, Alain ULg

in Environmental Pollution (1999), 104(3), 401-410

Jaccard's distances between the aquatic bryophyte assemblages recorded in 1972-1973 and in 1997 in nine study sites along the Belgian course of the rivers Meuse and Sambre were correlated with the ... [more ▼]

Jaccard's distances between the aquatic bryophyte assemblages recorded in 1972-1973 and in 1997 in nine study sites along the Belgian course of the rivers Meuse and Sambre were correlated with the differences of concentrations of 13 physico-chemical factors (O2, N-NO2-. N-NH4+, N-NO3-, P-PO43-, K+, pH, Ca++, Fe, Cu, Pb, Zn and Mn) between 1972-1973 and 1996. The strong decrease in heavy metals pollution and the decrease of the trophic level are correlated with the recolonization of the most polluted sites in the 1970s by the pollution-sensitive species present in the valleys at the beginning of the century. Conversely, N-NO2-, N-N03" and K+ have increased between the two surveys. They currently reach much higher concentrations in the Sambre than in the Meuse, as well as N and micro-pollutants such as pyrene and anionic detergents. The different loads of these factors in the studied rivers might explain their different recolonization patterns. Although some species might have developed a tolerance to certain factors, an effort to improve the quality of the effluents coming from industrial areas still remains to be made, especially in the frame of the projects of river flooding of the riverine areas. [less ▲]

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See detailMolecular and cellular basis of the altered immune response against arsonate in irradiated A/J mice autologously reconstituted.
Ismaili, Jamila; Razanajaona, Diane; Van Acker, Annette et al

in International Immunology (1999), 11(7), 1157-67

The humoral immune response to arsonate (Ars) in normal A/J mice is dominated in the late primary and particularly in the secondary response by a recurrent and dominant idiotype (CRIA) which is encoded by ... [more ▼]

The humoral immune response to arsonate (Ars) in normal A/J mice is dominated in the late primary and particularly in the secondary response by a recurrent and dominant idiotype (CRIA) which is encoded by a single canonical combination of the variable gene segments: VHidcr11-DFL16.1-JH2 and Vkappa10-Jkappa1. Accumulation of somatic mutations within cells expressing this canonical combination or some less frequent Ig rearrangements results in the generation of high-affinity antibodies. By contrast, in partially shielded and irradiated A/J mice (autologous reconstitution) immunized with Ars-keyhole limpet hemocyanin (KLH), both the dominance of the CRIA idiotype and the affinity maturation are lost, whereas the anti-Ars antibody titer is not affected. To understand these alterations, we have analyzed a collection of 27 different anti-Ars hybridomas from nine partially shielded and irradiated A/J mice that had been immunized twice with Ars-KLH. Sequence analysis of the productively rearranged heavy chain variable region genes from those hybridomas revealed that (i) the canonical V(D)J combination was rare, (ii) the pattern of V(D)J gene usage rather corresponded to a primary repertoire with multiple gene combinations and (iii) the frequency of somatic mutations was low when compared to a normal secondary response to Ars. In addition, immunohistological analysis has shown a delay of 2 weeks in the appearance of full blown splenic germinal centers in autoreconstituting mice, as compared to controls. Such a model could be useful to understand the immunological defects found in patients transplanted with bone marrow. [less ▲]

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See detailA nouveau des questions sur les droits du C.P.A.S. à l'égard des débiteurs alimentaires
Paris, Catherine ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detailFactors determining the percentage of hypochromic red blood cells in hemodialysis patients.
Bovy, Christophe ULg; Tsobo, C.; Crapanzano, L. et al

in Kidney International (1999), 56(3), 1113-9

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO ... [more ▼]

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO) has been advocated as a sensitive index of functional iron deficiency during erythropoietin (EPO) therapy in hemodialyzed patients. METHODS: The significance of %HYPO in chronic renal failure was evaluated in 64 chronically hemodialyzed patients. The linear correlation was determined between %HYPO and 13 variables, including age, sex, weight, C-reactive protein (CRP), ferritin, transferrin (Tf), Tf saturation, soluble Tf receptor (sTfR), serum iron (SI), urea, parathormone, dialysis dose (Kt/V), dose of EPO administered (EPO), and absolute reticulocyte count. Multiple regression analyses were then performed to select the parameters that jointly provide the best prediction of %HYPO. RESULTS: Univariate analysis showed significant correlations between %HYPO and iron parameters (sTfR, Tf saturation, SI, and ferritin, in decreasing order), EPO, reticulocyte count, and CRP. Multivariate analysis yielded an equation showing that the variation of %HYPO is essentially associated with the combined changes in sTfR, CRP, and EPO dosage. CONCLUSIONS: %HYPO is a meaningful and inexpensive parameter that reflects the integrated effects of iron stores, inflammation, and erythropoietic stimulation on iron availability in hemodialyzed patients. Among iron exchange parameters, sTfR is the best predictor of %HYPO, followed by Tf saturation, SI, and ferritin. [less ▲]

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See detailLimited clinical utility of a self-evaluating risk assessment scale for postmenopausal osteoporosis: lack of predictive value of lifestyle-related factors
Goemaere, S; Zegels, Brigitte ULg; Toye, K et al

in Calcified Tissue International (1999), 65(5), 354-358

The aim of this study was to assess the efficiency of a self-administered questionnaire to identify subjects with postmenopausal osteoporosis in the setting of first line medical care. A sample of 300 ... [more ▼]

The aim of this study was to assess the efficiency of a self-administered questionnaire to identify subjects with postmenopausal osteoporosis in the setting of first line medical care. A sample of 300 postmenopausal women completed the questionnaire based on 18 items. Bone mineral density at the lumbar spine (BMD-L), total hip (BMD-H), and femoral neck (BMD-N) was used as objective criterion for evaluation. The mean risk score was 8.2 +/- 3.21. BMD was correlated with total risk score: r = -0.32 for BMD-L, -0.36 for BMD-N, and -0.43 for BMD-H. Cutoff points for the risk score (equal likelihood points) according to a T-score threshold of -2.5 were 8.6 for BMD-L and BMD-N and 9.3 for BMD-H; specificity and sensitivity was 62% and 62%, respectively, for BMD-L, 65% and 62% for BMD-N, and 75% and 63% for BMD-H. Stepwise multiple regression analysis of the questionnaire items in relation to BMD showed higher correlation coefficients for models including individual items rather than the overall risk score. Items concerning low weight, older age, and wrist fracture after 50 years of age were always selected as significant determinants of BMD (R = 0.43-0.55). Hormonal replacement therapy was also an important determinant. Lifestyle-related items did not contribute significantly. In conclusion, the diagnostic performance of the 18-item self-administered questionnaire was poorer than a shortened questionnaire omitting lifestyle factors. The clinical utility of a questionnaire should ultimately be evaluated in the specific optic of a chosen global strategy for prevention of osteoporotic fractures. [less ▲]

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See detailPharma clinics. Comment je traite ... les troubles de la calcémie
Janssens, Lise; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(10), 782-785

Treatment of both hypercalcemia and hypocalcemia depends on the underlying disorder, the magnitude of the calcium abnormalities and the severity of symptoms. In the case of hypercalcemia, there is a broad ... [more ▼]

Treatment of both hypercalcemia and hypocalcemia depends on the underlying disorder, the magnitude of the calcium abnormalities and the severity of symptoms. In the case of hypercalcemia, there is a broad selection of effective medications, especially the biphosphonates. Treatment of hypocalcemia relies on the calcium intake and often vitamin D supplementation. For both abnormalities, the underlying cause must be treated, if possible, to definitively restore normocalcemia. [less ▲]

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See detailLa mortalité embryonnaire. 1. Aspects cliniques et facteurs étiologiques dans l'espèce bovine
Hanzen, Christian ULg; Drion, Pierre ULg; Lourtie, O. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailPlatyhypnidium mutatum, a mysterious new moss from Germany
Ochyra, R.; Vanderpoorten, Alain ULg

in Journal of Bryology (1999), 21

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See detailQuantifying scale-dependent effects of cove-dwellers movements with connectivity models
Henry, Valérie ULg; Tercafs, R.

in Mémoires de Biospéologie (1999), XXVI

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See detailThe X-ray emission spectra of multicharged xenon ions in a gas puff laser-produced plasma
Yu Skobelev, I.; Dyakin, V. M.; Ya Faenov, A. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1999), 32

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See detailDevelopment of a Cough Induction Test in Pigs: Effects of Sr 48968 and Enalapril
Moreaux, B.; Beerens, Dominique ULg; Gustin, Pascal ULg

in Journal of Veterinary Pharmacology & Therapeutics (1999), 22(6), 387-389

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See detailInteractively converging on context-sensitive representations: a solution to the frame problem
French, Robert M; Anselme, Patrick ULg

in Revue Internationale de Philosophie (1999), 209(3), 365-385

While we agree that the frame problem, as initially stated by McCarthy and Hayes (1969), is a problem that arises because of the use of representations, we do not accept the anti-representationalist ... [more ▼]

While we agree that the frame problem, as initially stated by McCarthy and Hayes (1969), is a problem that arises because of the use of representations, we do not accept the anti-representationalist position that the way around the problem is to eliminate representations. We believe that internal representations of the external world are a necessary, perhaps even a defining feature, of higher cognition. We explore the notion of dynamically created context-dependent representations that emerge from a continual interaction between working memory, external input, and long-term memory. We claim that only this kind of representation, necessary for higher cognitive abilities such as counterfactualization, will allow the combinatorial explosion inherent in the frame problem to be avoided. Introduction You live in a tidy little suburb of America. You call up a friend and invite him to have a drink. He agrees to meet you at seven. But then, just before you hang up, he adds, 'Unless my wife has scheduled something else for this evening.' You think: that's reasonable. Then he adds, 'Unless the bar doesn't exist anymore.' You think: that's a bit strange since the bar was there three months before. Then he adds, 'Unless I'm killed on the way there.' You begin to wonder if you really want to have a drink with him. And finally, he adds, 'Unless a meteorite destroys the earth' and you suddenly remember a prior engagement. But what, exactly, makes some of these conditions perfectly reasonable, others crazy? The philosophical problem is that we cannot exclude any of them a priori because contexts do exist in which they would be perfectly appropriate remarks. For example, if the bar in question was a theme bar devoted to punk rock music, or if the conversation had occurred in London in 1942 or in Sarajevo fifty years later, or if on that day the earth happened to be passing through a dense band of meteorites the size of Madagascar.... [less ▲]

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See detailElaboration de courbes de croissance en hauteur dominante pour les mélèzes (Larix decidua Mill. et Larix kaempferi (Lamb.) Carr.) en Belgique méridionale
Pauwels, Dominique; Thibaut, André; Lejeune, Philippe ULg et al

in Annals of Forest Science : a Multidisciplinary and International Journal (1999), 56(1), 27-34

Site index curves have been determined for Japanese and European larch in Wallonia (Southern Belgium, figure 1). Seven models have been tested (figure 2) to adjust the data from stem analysis in 19 stands ... [more ▼]

Site index curves have been determined for Japanese and European larch in Wallonia (Southern Belgium, figure 1). Seven models have been tested (figure 2) to adjust the data from stem analysis in 19 stands for Japanese larch and in eight stands for European larch (table I). The mean squares of the models have permitted to compare each other (table II). The Duplat et Tran-Ha model IV is the most suitable to describe the dominant height growth. The information issued from 194 temporary plots (134 in Japanese larch stands and 60 in European larch) is used to determine five productivity levels based upon equal intervals of 3 m between 34 and 22 m of dominant height at 50 years (figures 3 and 4). Considering the little height growth difference between the two species of larch (figure 5 and table IV), a unique model is retained (table V). The growth speed is presented in figure 6. [less ▲]

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See detailModeling groundwater with ocean and river interaction
Carabin, Guy; Dassargues, Alain ULg

in Water Resources Research (1999), 35(8), 2347-2358

We develop and implement the groundwater model, Saturated/Unsaturated Flow and Transport in 3D (SUFT3D), to integrate water quantity/quality data and simulations with models of other hydrologic cycle ... [more ▼]

We develop and implement the groundwater model, Saturated/Unsaturated Flow and Transport in 3D (SUFT3D), to integrate water quantity/quality data and simulations with models of other hydrologic cycle components, namely, rivers and the ocean. This work was done as part of the Sea Air Land Modeling Operational Network (SALMON) project supported by the IBM International Foundation through its Environmental Research Program. The first research steps, presented here, address the simulation of typical hydrologic conditions to demonstrate SUFT3D's effectiveness and accuracy. The theory behind the modeling of seawater intrusion and groundwater-river interaction is summarized along with the numerical methods and characteristics of SUFT3D. The code was applied to different, increasingly complex scenarios: confined to unconfined conditions, local to regional scale, homogeneous to increasing heterogeneity, two- to three-dimensional. Of particular interest were the impacts of different boundary conditions and influence of river interactions on seawater intrusion. Results are illustrated, discussed, and compared, when possible, to those in the literature. Simulating groundwater exchange between both the river and the ocean has provided interesting results that better depict the dynamics of flow and transport in coastal zone groundwater systems. [less ▲]

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See detailInventaire des plantes aquatiques du lit majeur de la Moselle, France, Luxembourg et Allemagne
Klein, J. P.; Vanderpoorten, Alain ULg

in Willemetia (1999), 3(18), 1-6

The inventory of the aquatic flora found in the Moselle river indicates the state of botanical knowledge at the end of 1999. It includes a total of 48 aquatic macrophytes and 20 bryophytes. Among the ... [more ▼]

The inventory of the aquatic flora found in the Moselle river indicates the state of botanical knowledge at the end of 1999. It includes a total of 48 aquatic macrophytes and 20 bryophytes. Among the recorded species two are protected in France (Luronium natans, Pilularia globulifera) and two in the Lorraine region (Potamogeton gramineus, Vallisneria spiralis). [less ▲]

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See detailPharma-clinics. Le medicament du mois. L'aceclofenac (Biofenac).
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 62-4

Aceclofenac, a phenylacetic acid derivative, is a new nonsteroidal anti-inflammatory drug (NSAID). It is indicated in the symptomatic treatment of pain and inflammatory or degenerative arthropathies ... [more ▼]

Aceclofenac, a phenylacetic acid derivative, is a new nonsteroidal anti-inflammatory drug (NSAID). It is indicated in the symptomatic treatment of pain and inflammatory or degenerative arthropathies: osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, abarticular inflammations, posttrauma or postoperative inflammations. The usual oral dosage of aceclofenac is 100 mg twice daily in adults. Its clinical efficacy seems to be similar to that of other NSAIDs, but its safety profile, especially gastro-intestinal tolerance, appears to be better. Finally, in vitro studies suggested that aceclofenac may exert positive effect on cartilage matrix metabolism. [less ▲]

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See detailPériartérite noueuse en relation avec une hépatite B
Demolin, G.; Delwaide, Jean ULg; Van Severen, M. et al

in Revue Médicale de Liège (1999), 54(1), 921-924

A 66-year-old man was hospitalized for asthenia, weight loss, fever and chills. A polyarteritis nodosa associated with hepatitis B virus infection in a replicative phase was diagnosed. Etiology ... [more ▼]

A 66-year-old man was hospitalized for asthenia, weight loss, fever and chills. A polyarteritis nodosa associated with hepatitis B virus infection in a replicative phase was diagnosed. Etiology, physiopathology, and clinical characteristics of hepatitis B virus-related polyarteritis nodosa will be reviewed, as well as the effectiveness of therapy combining corticosteroids, interferon alpha and plasma exchanges. [less ▲]

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See detailLa nouvelle procédure contentieuse en matière de taxes provinciales et communales
Orban, Lionel ULg

in Actualités du Droit (1999)

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See detailAnomalous behavior of the irreversible magnetization and time relaxation in YBa(2)Cu(3)O(7) single crystals with splayed tracks
Silhanek, Alejandro ULg; Niebieskikwiat, D.; Civale, L. et al

in Physical Review. B : Condensed Matter (1999), 60(18), 13189-13195

We have studied the angular dependence of the irreversible magnetization and its time relaxation in YBa(2)Cu(3)O(7) Single crystals with one or two families of columnar defects inclined with respect to ... [more ▼]

We have studied the angular dependence of the irreversible magnetization and its time relaxation in YBa(2)Cu(3)O(7) Single crystals with one or two families of columnar defects inclined with respect to the c axis. At high magnetic fields, the magnetization shows the usual maximum centered at the mean tracks' orientation and an associated minimum in the normalized relaxation rate. In contrast, at low fields we observe an anomalous local minimum in the magnetization and a maximum in the relaxation rate. We present a model to explain this anomaly based on the slowing down of the creep processes arising from the increase of the vortex-vortex interactions as the applied field is tilted away from the mean tracks' direction. [S0163-1829(99)11841-1]. [less ▲]

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See detailPrise en charge diagnostique d'un amas de calcifications atypiques par la méthode MIBB
LIFRANGE, Eric ULg; BOURDOUX, B; DESREUX, Joëlle ULg et al

in Gunaïkeia (1999), 4

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See detailActualites therapeutiques 1999.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(9), 725-34

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be stressed. [less ▲]

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See detailA novel approach to the study of familial influences on evoked cortical responses in migraine.
Schoenen, Jean ULg; Sandor, P. S.

in Cephalalgia : An International Journal of Headache (1999), 19 Suppl 24

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See detailTrophic Response Curves of Aquatic Bryophytes in Lowland Calcareous Streams
Vanderpoorten, Alain ULg; Durwael, L.

in Bryologist (1999), 102(4), 720-728

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See detailWhole-body positron emission tomography using 18F-fluorodeoxyglucose for posttreatment evaluation in Hodgkin's disease and non-Hodgkin's lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imaging.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Blood (1999), 94(2), 429-33

A residual mass after treatment of lymphoma is a clinical challenge, because it may represent vital tumor as well as tissue fibrosis. Metabolic imaging by 18F-fluorodeoxyglucose (18F-FDG) positron ... [more ▼]

A residual mass after treatment of lymphoma is a clinical challenge, because it may represent vital tumor as well as tissue fibrosis. Metabolic imaging by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) offers the advantage of functional tissue characterization that is largely independent of morphologic criteria. We compared 18F-FDG PET to computed tomography (CT) in the posttreatment evaluation of 54 patients with Hodgkin's disease (HD) or intermediate/high-grade non-Hodgkin's lymphoma (NHL). Residual masses on CT were observed in 13 of 19 patients with HD and 11 of 35 patients with NHL. Five of 24 patients with residual masses on CT versus 1 of 30 patients without residual masses presented a positive 18F-FDG PET study. Relapse occurred in all 6 patients (100%) with a positive 18F-FDG PET, 5 of 19 patients (26%) with residual masses on CT but negative 18F-FDG PET, and 3 of 29 patients (10%) with negative CT scan and 18F-FDG PET studies (P </=.0001). We observed a higher relapse and death rate in patients with residual masses at CT compared with patients without residual masses at CT (progression-free survival at 1 year: 62 +/- 10 v 88 +/- 7%, P =. 0045; overall survival at 1 year: 77 +/- 5 v 95 +/- 5%, P =.0038). A positive 18F-FDG PET study was even more consistently associated with poorer survival: compared with patients with a negative 18F-FDG PET study, the 1-year progression-free survival was 0% versus 86% +/- 5% (P <.0001) and the 1-year overall survival was 50% +/- 20% versus 92% +/- 4% (P <.0001). The detection of vital tumor by 18F-FDG PET after the end of treatment has a higher predictive value for relapse than classical CT scan imaging (positive predictive value: 100% v 42%). This could help identify patients requiring intensification immediately after completion of chemotherapy. However, 18F-FDG PET mainly predicts for early progression but cannot exclude the presence of minimal residual disease, possibly leading to a later relapse. [less ▲]

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See detailDelayed massive immune hemolysis mediated by minor ABO incompatibility after allogeneic peripheral blood progenitor cell transplantation.
Salmon, Jean ULg; Michaux, S.; Hermanne, J. P. et al

in Transfusion (1999), 39(8), 824-7

BACKGROUND: Bone marrow transplantation with minor ABO incompatibility may be followed by moderate delayed hemolysis of the recipient's red cells by donor-derived ABO antibodies. This reaction may be more ... [more ▼]

BACKGROUND: Bone marrow transplantation with minor ABO incompatibility may be followed by moderate delayed hemolysis of the recipient's red cells by donor-derived ABO antibodies. This reaction may be more severe after transplantation of peripheral blood progenitor cells (PBPCs). CASE REPORT: A 16-year-old boy underwent an allogeneic PBPC transplant from his HLA-mismatched mother as treatment for acute myeloblastic leukemia that had proved resistant to induction chemotherapy. Transfusion of the unmanipulated PBPCs proceeded without any complication, despite the difference in ABO blood group (donor, O Rh-positive; recipient, A Rh-positive). On Day 7, a rapid drop in hemoglobin to 4 g per dL was observed, which was attributed to a massive hemolysis. All the recipient's group A red cells were destroyed within 36 hours. This delayed and rapidly progressive hemolytic anemia was not associated with the transfusion of the donor's plasma. Rather, the anti-A titer increased in parallel with marrow recovery, which suggested an active synthesis of these antibodies by immunocompetent cells from the donor against the recipient's red cells. The mother's anti-A titer was retrospectively found to be 2048. Her unusually high titer is probably due to prior sensitization during pregnancies. On Day 12, the patient developed grade IV graft-versus-host disease, which proved resistant to all treatments instituted and led to his death on Day 35. CONCLUSION: PBPC transplantation with minor ABO incompatibility may be associated with significant risk of massive delayed hemolysis. [less ▲]

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See detailA targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line
Cocea, L.; De Smet, A.; Saghatchian, M. et al

in Journal of Experimental Medicine (1999), 189

We have shown previously that a mutation of the KI-KII site immediately 5' to J(kappa)1 on the mouse immunoglobulin light chain kappa locus reduces the rearrangement level in cis, although it does not ... [more ▼]

We have shown previously that a mutation of the KI-KII site immediately 5' to J(kappa)1 on the mouse immunoglobulin light chain kappa locus reduces the rearrangement level in cis, although it does not affect transcription. Here we deleted by homologous recombination in mouse embryonic stem cells a 4-kb DNA fragment, located immediately upstream of the KI-KII element, which contains the promoter of the long germline transcript. Analysis of gene-targeted heterozygous mouse splenic B cells showed a strong decrease in rearrangement for the allele bearing the deletion. When both the KI-KII mutation and the 4-kb deletion were present on the same allele, the overall reduction in rearrangement was stronger than with the 4-kb deletion alone underlying the role of these two elements in the regulation of rearrangement. The same deletion was performed by homologous recombination on one allele of the rearrangement-inducible mouse 103/bcl2-hygro(R) pre-B cell line, and resulted in a similar reduction in the induction of rearrangement of the mutated allele. This result validates this cell line as an in vitro model for studying the incidence of gene-targeted modifications of the kappa locus on the regulation of rearrangement [less ▲]

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See detailLe Mélèze
Jourez, Benoît ULg; Pauwels, Dominique; Jacques, Dominique et al

in Courrier du Bois (1999), 125

De la famille des pinacées, le Mélèze, ou plutôt les Mélèzes, car ils sont trois chez nous à se partager ce titre générique, produisent un bois à la durabilité reconnue et à l'esthétique appréciée. Leurs ... [more ▼]

De la famille des pinacées, le Mélèze, ou plutôt les Mélèzes, car ils sont trois chez nous à se partager ce titre générique, produisent un bois à la durabilité reconnue et à l'esthétique appréciée. Leurs qualités technologiques sont susceptibles de satisfaire les exigences des utilisateurs dans des domaines très variés, tant en usage intérieur qu'extérieur. Cette essence n'a cependant pas la popularité qu'elle mérite auprès des sylviculteurs, malgré un potentiel de croissance élevé. [less ▲]

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See detailCanopy gap morphology determinants in an Amazonian rain forest.
Salvador-Van Eysenrode, D; Bogaert, Jan ULg; Impens, I

in Selbyana (1999), 20(2), 339-344

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See detailActualités thérapeutiques dans le traitement du cancer colorectal
Jerusalem, Guy ULg; Bours, Vincent ULg; Fillet, Georges ULg

in Médecine et Hygiène (1999), 57

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See detailMono- and binuclear Zn2+-beta-lactamase. Role of the conserved cysteine in the catalytic mechanism.
Paul-Soto, R.; Bauer, R.; Frère, Jean-Marie ULg et al

in The Journal of biological chemistry (1999), 274(19), 13242-9

When expressed by pathogenic bacteria, Zn2+-beta-lactamases induce resistance to most beta-lactam antibiotics. A possible strategy to fight these bacteria would be a combined therapy with non-toxic ... [more ▼]

When expressed by pathogenic bacteria, Zn2+-beta-lactamases induce resistance to most beta-lactam antibiotics. A possible strategy to fight these bacteria would be a combined therapy with non-toxic inhibitors of Zn2+-beta-lactamases together with standard antibiotics. For this purpose, it is important to verify that the inhibitor is effective under all clinical conditions. We have investigated the correlation between the number of zinc ions bound to the Zn2+-beta-lactamase from Bacillus cereus and hydrolysis of benzylpenicillin and nitrocefin for the wild type and a mutant where cysteine 168 is replaced by alanine. It is shown that both the mono-Zn2+ (mononuclear) and di-Zn2+ (binuclear) Zn2+-beta-lactamases are catalytically active but with different kinetic properties. The mono-Zn2+-beta-lactamase requires the conserved cysteine residue for hydrolysis of the beta-lactam ring in contrast to the binuclear enzyme where the cysteine residue is not essential. Substrate affinity is not significantly affected by the mutation for the mononuclear enzyme but is decreased for the binuclear enzyme. These results were derived from kinetic studies on two wild types and the mutant enzyme with benzylpenicillin and nitrocefin as substrates. Thus, targeting drug design to modify this residue might represent an efficient strategy, the more so if it also interferes with the formation of the binuclear enzyme. [less ▲]

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See detailDevelopment of a parenteral and of an oral formulation of albendazole with cyclodextrins
Piel, Géraldine ULg; Evrard, Brigitte ULg; Van Hees, Thierry ULg et al

in STP Pharma Sciences (1999), 3

L'albendazole est une dérivé benzimidazole à large spectre d'activité contre les parasites helminthiques de l'homme et de l'animal. L'albendazole est très faiblement soluble dans l'eau. Il a été démontré ... [more ▼]

L'albendazole est une dérivé benzimidazole à large spectre d'activité contre les parasites helminthiques de l'homme et de l'animal. L'albendazole est très faiblement soluble dans l'eau. Il a été démontré que les cyclodextrines sont capables de former des complexes d'inclusion avec l'albendazole et d'en augmenter la solubilité. La solubilité aqueuse de l'albendazole est dépendante du pH. Le but de ce travail est d'étudier l'influence combinée des cyclodextrines et de différents acides sur la solubilité de l'albendazole. Il a été démontré qu'il existe un véritable effet synergique entre les cyclodextrines et les différents acides. L'utilisation combinée d'hydroxypropyl-b-cyclodextrine (200 mM) et d'acide lactique ou acide citrique (50 mM) permet de dissoudre plus de 1 mg/ml d'albendazole. Des études RMN ont démontré l'inclusion de l'albendazole dans la b-cyclodextrine en milieu acide. Ces résultats montrent qu'il est possible de réaliser une solution injectable et une solution orale d'albendazole grâce aux cyclodextrines. [less ▲]

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See detailProbabilistic design of power-system special stability controls
Wehenkel, Louis ULg; Lebrevelec, Cyril; Trotignon, Marc et al

in Control Engineering Practice (1999), 7(2), 183-194

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and ... [more ▼]

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and fast dynamics, and modeling uncertainties. A large number of scenarios are simulated in parallel by time-domain numerical integration, and the relevant parameters of the resulting system trajectories are stored in a database. Data-mining tools are used to identify the most important system weaknesses and possible improvements. The approach is tested on a large-scale study on the SouthÐEastern part of the extra-high-voltage system of Electricité de France. [less ▲]

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