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See detailUn outil d’optimisation des structures orthotropes intégré à l’avant-projet
Rigo, Philippe ULg

in Construction Métallique (2000)

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See detailCellulite: from standing fat herniation to hypodermal stretch marks.
Pierard, Gérald ULg; NIZET, Jean-Luc ULg; PIERARD-FRANCHIMONT, Claudine ULg

in American Journal of Dermatopathology (2000), 22(1), 34-7

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens ... [more ▼]

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens. A control group consisted of 4 women and 11 men showing no evidence of cellulite. The lumpy aspect of the dermohypodermal interface appeared to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite identified by the mattress phenomenon was related to the presence of focally enlarged fibrosclerotic strands partitioning the subcutis. Such strands possibly serve as a physiologic buttress against fat herniation limiting the outpouching of fat lobules on pinching the skin. These structures might represent a reactive process to sustained hypodermal pressure caused by fat accumulation. Full-blown cellulite likely represents subjugation of the hypertrophic response when connective tissue is overcome by progressive fat accumulation. Histologic aspects reminiscent of stretch marks are identified within the hypodermal strands, resulting in clinical skin dimpling. [less ▲]

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See detailLaser-induced transitions between triply excited hollow states
Madsen, L. B.; Schlagheck, Peter ULg; Lambropoulos, P.

in Physical Review Letters (2000), 85(1), 42-45

We present an ab initio calculation of the Li+ photoion yield in the presence of laser coupling between the triply; excited 2s(2)2p(2)P(o) and 2s2p(2) D-2(e) resonances in lithium, the first of which is ... [more ▼]

We present an ab initio calculation of the Li+ photoion yield in the presence of laser coupling between the triply; excited 2s(2)2p(2)P(o) and 2s2p(2) D-2(e) resonances in lithium, the first of which is assumed excited by synchrotron radiation from the ground state. The laser coupling between the triply excited states is shown to lead to a significant and readily measurable modification of the line profile which provides a unique probe of the dipole strength between highly correlated triply excited states. [less ▲]

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See detailSignificance of random illite-vermiculite mixed layers in Pleistocene sediments of the northwestern Atlantic Ocean
Vanderaveroet, P.; Bout-Roumazeilles, V.; Fagel, Nathalie ULg et al

in Clay Minerals (2000), 35(4), 679-691

The clay mineralogy of Pleistocene sediments of eleven sediment cores at three ODP sites from 30 degrees N to 60 degrees N northwestern Atlantic Ocean has been investigated. The sediments are ... [more ▼]

The clay mineralogy of Pleistocene sediments of eleven sediment cores at three ODP sites from 30 degrees N to 60 degrees N northwestern Atlantic Ocean has been investigated. The sediments are characterized by the presence of random illite-vermiculite mixed layers (I-V) (up to 32% of the clay mineral assemblage). The I-V clays are much more abundant during interglacial periods than during glacial ones. They are attributed to detrital supply through erosion of high-latitude continental areas from which they are derived mainly from chemical weathering of micaceous phyllosilicates. Their spatial distribution and the specific conditions for their formation through weathering suggest that I-V mixed layers are mainly derived from the Canadian Shield. They were transported From their source to marine deposition areas by rivers, deep water masses or nepheloid layers. Due to the specific conditions required For the Formation of I-V, its occurrence and abundance are used as a palaeoclimate and palaeocirculation proxy for northwestern Atlantic Pleistocene sediment. [less ▲]

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See detailConstruire l'esprit du dauphin
Servais, Véronique ULg

in Terrain (2000), 34

Comparisons are made of how the dolphin’s “mind” is “constructed” in six interactional contexts distinguished by the degree of participation (in the ethnological sense of the term) by human beings or even ... [more ▼]

Comparisons are made of how the dolphin’s “mind” is “constructed” in six interactional contexts distinguished by the degree of participation (in the ethnological sense of the term) by human beings or even by the dolphins themselves: the study of the brain, the study of sensorial capabilities, research on cognition, naturalistic observations, communication among dolphins, and meetings on the high sea. On the basis of these comparisons, it is argued that whether or not people attribute a “mind” to the dolphin very much depends on the degree of likeness that they recognize with these animals, which, in turn, depends on the person’s capacity to let himself be “affected” by them. [less ▲]

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See detailAdenovirus infections in pigeons
Duchatel, Jean-Pierre ULg; Marlier, Didier ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (2000), 144(1), 13-17

This paper describes the different clinical aspects of the adenovirus infections in pigeons. Etiology, epidemiology, pathogenesis, diagnosis and treatment are discussed. The two specific clinical ... [more ▼]

This paper describes the different clinical aspects of the adenovirus infections in pigeons. Etiology, epidemiology, pathogenesis, diagnosis and treatment are discussed. The two specific clinical syndromes of pigeons are mainly described: classical adenovirus and necrotizing-hepatitis. [less ▲]

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See detailOsmotic behaviour of in vitro produced bovine blastocysts in cryoprotectant solutions as a potential predictive test of survival
Kaidi, Safia; Donnay, I.; Lambert, Philippe ULg et al

in Cryobiology (2000), 41

The osmotic behavior of bovine blastocysts produced in vitro was filmed during exposure to and dilution of cryoprotectant solutions used for vitrification. The relationship between the changes in the ... [more ▼]

The osmotic behavior of bovine blastocysts produced in vitro was filmed during exposure to and dilution of cryoprotectant solutions used for vitrification. The relationship between the changes in the diameter of embryos and their subsequent survival was assessed. Embryos collected on Day 6 and Day 7 postinsemination were exposed to 10% glycerol (GLY) for 5 min, 10% GLY + 20% ethylene glycol (EG) for 5 min, and 25% Gly + 25% EG for 30 s, before dilution in 0.85 M galactose and finally in embryo transfer freezing medium (ETF). Embryos that had a higher probability of survival behaved as perfect osmometers, shrinking, reexpanding, or swelling according to an identical pattern, whereas embryos that deviated from this standard usually did not survive. The initial embryo diameter, duration of shrinkage and expansion in 10% glycerol, duration of reexpansion in ETF, and final embryo diameter were clearly predictive of the ability to hatch after culture in vitro. On a given day postinsemination, larger blastocysts were more likely than smaller blastocysts to survive and hatch after exposure to cryoprotectants with or without vitrification. [less ▲]

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See detailNumerical discretization of rotated diffusion operators in ocean models
Beckers, Jean-Marie ULg; Burchard, Hans; Deleersnijder, Eric et al

in Monthly Weather Review (2000), 128(8), 2711-2733

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on ... [more ▼]

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on the so-called z-coordinate system is presented. The authors then focus exclusively on the dynamically passive tracers and analyze some different approaches to the numerical discretization. Monotonic schemes are designed but are found to be rather complex, while simpler, linear schemes are shown to produce unphysical undershooting and overshooting. It is suggested that the choice of an appropriate discretization method depends on the importance of the rotated diffusion in a given simulation, whether the field to be diffused is dynamically active or not. [less ▲]

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See detailTreating families of individuals with traumatic brain injury : Presentation of clinical cases approached from a structural therapy perspective
Laroi, Frank ULg

in Journal of Family Psychotherapy (2000), 11

A traumatic brain injury may have a great impact on the family as a whole and may include changes in the family's organizational structure, communication patterns, or balance of family needs. In spite of ... [more ▼]

A traumatic brain injury may have a great impact on the family as a whole and may include changes in the family's organizational structure, communication patterns, or balance of family needs. In spite of this, treatment strategies for these problems are only slowly being recognized, resulting in either family reactions being inadequately addressed in rehabilitative programs, or treatment being approached from a family support perspective and not from a family therapy perspective. The aim of the following paper is to illustrate how family therapeutical approaches can be used in treating families of individuals with brain injury, in particular, structural interventions. Clinical examples will be presented where structural interventions were utilized with brain injury patients and their families. Other inverventional approaches from family therapy will also be mentioned. [less ▲]

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See detailEspaces scolaires et violence
Born, Michel ULg

in PEB Echanges (2000)

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See detailPET scanning and neuronal loss in acute vegetative state
Laureys, Steven ULg; Faymonville, Marie ULg; Moonen, Gustave ULg et al

in Lancet (2000), 355(9217), 1825-1826

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See detailComparaison des treillis classiques de type Warren, Pratt et Howe : optimisation et prédimensionnement sur base d'indicateurs morphologiques
Latteur, Pierre ULg; Samyn, Philippe; De Wilde, Patrick

in Revue Française de Génie Civil (2000), 4

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See detailLat. migdilix (Plaute, Poenulus, 1033)
Rochette, Bruno ULg

in Etudes Classiques (Namur, Belgium) (2000), 68

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See detailDeveloppement et utilisation d'un systeme de telemedecine pour le suivi medical des patients diabetiques.
Ordonez, A. J.; Rodriguez-Castro, C.; Zamora, J. et al

in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (2000)

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See detailAcute pancreatitis attributed to the use of interferon alfa-2b
Eland, I. A.; Rasch, M. C.; Sturkenboom, M. J. et al

in Gastroenterology (2000), 119(1), 230-233

Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection. The first patient was a 40-year-old man ... [more ▼]

Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection. The first patient was a 40-year-old man who developed acute pancreatitis after 15 weeks of treatment with 3 MU IFN-alpha subcutaneously (SC) 3 times weekly and 1200 mg ribavirin. After disappearance of symptoms and normalization of laboratory values, oral intake of solid foods and IFN-alpha therapy were restarted. Within hours, a relapse of acute pancreatitis occurred. A rechallenge with IFN-alpha 4 days later was followed by a prompt increase in serum lipase level, and IFN-alpha therapy was discontinued. The second patient was a 38-year-old man who developed acute pancreatitis 2 hours after SC administration of 5 MU IFN-alpha. Ultrasound endoscopy showed sludge in the gallbladder. The patient was rechallenged 5 weeks later with 3 MU IFN-alpha SC. Although serum amylase and lipase levels increased after readministration of IFN-alpha, treatment was continued. The patient was readmitted 2 weeks later with severe abdominal pain, and IFN-alpha administration was discontinued. Considering the temporal relationship between the start of IFN-alpha treatment and development of acute pancreatitis, the absence of other clear etiologic factors for acute pancreatitis, disappearance of symptoms after discontinuation of IFN-alpha, and positive reactions to rechallenge, IFN-alpha is the most probable cause for development of acute pancreatitis in these patients. [less ▲]

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See detailNeuropsychologie de l'apprentissage implicte et de la mémoire procédurale
Meulemans, Thierry ULg

in Revue de Neuropsychologie (2000), 10(1), 129-157

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See detailLoss of plant organogenic totipotency in the course of in vitro neoplastic progression
Gaspar, Thomas ULg; Kevers, Claire ULg; Bisbis, Badia et al

in In Vitro Cellular & Developmental Biology-Plant (2000), 36(3), 171-181

The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under ... [more ▼]

The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under different circumstances: genetic variation in the cell population, epigenetic changes, disappearance of an organogenesis-promoting substance, etc. The same reasons may be evoked for the progressive and eventually irreversible loss of organogenic totipotency in the course of neoplastic progressions from hormone-independent tumors and hyperhydric teratomas to cancers. As in animal cells, plant cells at the end of a neoplastic progression have probably undergone several independent genetic accidents with cumulative effects. They indeed are characterized by atypical biochemical cycles from which they are apparently unable to escape. The metabolic changes are probably not the primary defects that cause cancer, rather they may allow the cells to survive. How these changes, namely an oxidative stress, affect organogenesis is not known. The literature focuses on somatic mutations and epigenetic changes that cause aberrant regulation of cell cycle genes and their machinery. [less ▲]

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See detailRestoration of thalamocortical connectivity after recovery from persistent vegetative state
Laureys, Steven ULg; Faymonville, Marie-Elisabeth ULg; Luxen, André ULg et al

in Lancet (2000), 355(9217), 1790-1791

Moreover, the performance on these factors is correlated to different anterior and posterior

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See detailL'écriture en chantier. Une brochure destinée aux enseignants du secondaire
Baye, Ariane ULg; Denooz, Régine

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), 7-8

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See detailLe désistement d'appel et l'acquiescement sont-ils (encore) prohibés en matière de divorce
Boularbah, Hakim ULg

in Divorce : Actualité Juridique, Sociale et Fiscale (2000)

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See detailNew strategy for the validation of chromatographic bioanalytical methods
Chapuzet, E.; Mercier, N.; Bervoas-Martin, S. et al

in STP Pharma Pratiques (2000), 10(1), 21-38

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See detailEvidence of nutriceutical effectiveness in the treatment of osteoarthritis
Reginster, Jean-Yves ULg; Gillot, Vincent; Bruyère, Olivier ULg et al

in Current Rheumatology Reports (2000), 2(6), 472-477

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See detailL'influence de l'article 6 de la Convention européenne des droits de l'homme sur la procédure pénale belge
Jacobs, Ann ULg; Berbuto, Sandra

in Revue de Droit International et de Droit Comparé (2000)

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See detailPlacental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency
Verhaeghe, J.; Bougoussa, M.; Van Herck, E. et al

in Clinical Endocrinology (2000), 53(5), 645-647

The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and ... [more ▼]

The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and IGF-I in a woman with pit-1 deficiency before, during and after pregnancy, resulting in the birth of a healthy child (not pit-1 deficient). Both PGH and IGF-I concentrations were below the assay detection limit before and after pregnancy. During pregnancy, PGH and IGF-I levels increased steadily; the concentrations of PGH and IGF-I in late pregnancy were comparable with levels previously measured in normal pregnancies. PGH and IGF-I concentrations were strongly correlated throughout pregnancy (r = 0.90; P = 0.002). PGH was undetectable in cord serum, whilst the IGF-I concentration was within the normal range. The findings of this case study corroborate the notion that PGH is the prime regulator of maternal serum IGF-I during pregnancy. [less ▲]

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See detailExample of application of the new strategy proposed for the validation of chromatographic bioanalytical methods
Chapuzet, E.; Mercier, N.; Bervoas-Martin, S. et al

in STP Pharma Pratiques (2000), 10(2), 79-101

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See detailRecommandations a propos du traitement de l'hypertension arterielle chez le patient diabetique.
Scheen, André ULg; Rorive, Marcelle ULg; Estrella, F. et al

in Revue Médicale de Liège (2000), 55(5), 376-82

Diabetes mellitus is frequently associated with arterial hypertension and the combination of the two entities markedly increases the cardiovascular risk and accelerates the progression of microangiopathy ... [more ▼]

Diabetes mellitus is frequently associated with arterial hypertension and the combination of the two entities markedly increases the cardiovascular risk and accelerates the progression of microangiopathy (more particularly nephropathy) in both type 1 and type 2 diabetic patients. Numerous international guidelines have been published during the last few years to help the practitioner in targeting ideal arterial blood pressure levels (lower in diabetic than in non-diabetic patients) and in selecting first-choice antihypertensive agents. We will concisely summarize the main messages of these recommendations and insist upon the persistence of uncertainties, or even the existence of inconsistencies, more particularly regarding preferential indications of antihypertensive agents in diabetic patients. [less ▲]

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See detailNeuroendocrine regulation of GnRH release in induced ovulators.
Bakker, Julie ULg; Baum, M. J.

in Frontiers in Neuroendocrinology (2000), 21(3), 220-62

GnRH is the key neuropeptide controlling reproductive function in all vertebrate species. Two different neuroendocrine mechanisms have evolved among female mammals to regulate the mediobasal hypothalamic ... [more ▼]

GnRH is the key neuropeptide controlling reproductive function in all vertebrate species. Two different neuroendocrine mechanisms have evolved among female mammals to regulate the mediobasal hypothalamic (MBH) release of GnRH leading to the preovulatory secretion of LH by the anterior pituitary gland. In females of spontaneously ovulating species, including rats, mice, guinea pigs, sheep, monkeys, and women, ovarian steroids secreted by maturing ovarian follicles induce a pulsatile pattern of GnRH release in the median eminence that, in turn, stimulates a preovulatory LH surge. In females of induced ovulating species, including rabbits, ferrets, cats, and camels, the preovulatory release of GnRH, and the resultant preovulatory LH surge, is induced by the receipt of genital somatosensory stimuli during mating. Induced ovulators generally do not show "spontaneous" steroid-induced LH surges during their reproductive cycles, suggesting that the positive feedback actions of steroid hormones on GnRH release are reduced or absent in these species. By contrast, mating-induced preovulatory surges occasionally occur in some spontaneously ovulating species. Most research in the field of GnRH neurobiology has been performed using spontaneous ovulators including rat, guinea pig, sheep, and rhesus monkey. This review summarizes the literature concerning the neuroendocrine mechanisms controlling GnRH biosynthesis and release in females of several induced ovulating species, and whenever possible it contrasts the results with those obtained for spontaneously ovulating species. It also considers the adaptive, evolutionary benefits and disadvantages of each type of ovulatory control mechanism. In females of induced ovulating species estradiol acts in the brain to induce aspects of proceptive and receptive sexual behavior. The primary mechanism involved in the preovulatory release of GnRH among induced ovulators involves the activation of midbrain and brainstem noradrenergic neurons in response to genital-somatosensory signals generated by receipt of an intromission from a male during mating. These noradrenergic neurons project to the MBH and, when activated, promote the release of GnRH from nerve terminals in the median eminence. In contrast to spontaneous ovulators, there is little evidence that endogenous opioid peptides normally inhibit MBH GnRH release among induced ovulators. Instead, the neural signals that induce a preovulatory LH surge in these species seem to be primarily excitatory. A complete understanding of the neuroendocrine control of ovulation will only be achieved in the future by comparative studies of several animal model systems in which mating-induced as well as spontaneous, hormonally stimulated activation of GnRH neurons drives the preovulatory LH surge. [less ▲]

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See detailGeneralization of automatic sequences for numeration systems on a regular language
Rigo, Michel ULg

in Theoretical Computer Science (2000), 244

Let L be an infinite regular language on a totally ordered alphabet (Σ,<). Feeding a finite deterministic automaton (with output) with the words of L, enumerated lexicographically with respect to <, leads ... [more ▼]

Let L be an infinite regular language on a totally ordered alphabet (Σ,<). Feeding a finite deterministic automaton (with output) with the words of L, enumerated lexicographically with respect to <, leads to an infinite sequence over the output alphabet of the automaton. This process generalizes the concept of k-automatic sequence for abstract numeration systems on a regular language (instead of systems in base k). Here, we study the first properties of these sequences and their relations with numeration systems. [less ▲]

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See detailPhylogenetic analysis of the pearlfish Carapini (Ophidiiformes, Carapidae)
Parmentier, Eric ULg; Castillo Cabello, Gabriel ULg; Chardon, Michel ULg et al

in Acta Zoologica (2000), 81

Fishes of the tribe Carapini (Encheliophis and Carapus) share a noteworthy peculiarity: they shelter in holothurian echinoderms or bivalve hosts. Some species are considered parasitic, others commensal ... [more ▼]

Fishes of the tribe Carapini (Encheliophis and Carapus) share a noteworthy peculiarity: they shelter in holothurian echinoderms or bivalve hosts. Some species are considered parasitic, others commensal. This study focuses on the phylogeny of the tribe, using two other Carapidae species as an outgroup (Snyderidia canina and Onuxodon fowleri). Insofar as possible, the selected anatomical and behavioural characters where chosen in an ecomorphological perspective, as features that could be responses to various lifestyle-related constraints. Our character selection also took into account the fact that some features are (presumably) linked. Such features were grouped together as a single trait to avoid their overvaluation. This methodology enabled us to separate commensals from parasites, the former belonging to Carapus and the latter to Encheliophis. Carapus species reflect in their morphology the constraints imposed by a diet of hard, mobile, elusive prey, showing predator-type features: a strong dentition, a wide mouth opening, a robust food intake apparatus. On the other hand, the endoparasitic Encheliophis species show a generally weaker buccal apparatus and narrow mouth opening, in relation to the different constraints of their lifestyle where the diet constraints are less pronounced: they eat body parts of their host. We propose changes in both generic diagnoses and transfer three species from Encheliophis to Carapus. [less ▲]

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See detailThe photoabsorption and Constant Ion State Spectroscopy of Vinyl Bromide.
Hoxha, A.; Locht, Robert ULg; Leyh, Bernard ULg et al

in Chemical Physics (2000), 260

In this paper we report the photoabsorption and the constant ion state spectroscopy of vinyl bromide (C2H3Br). The photoabsorption spectrum was measured using synchrotron radiation and was investigated in ... [more ▼]

In this paper we report the photoabsorption and the constant ion state spectroscopy of vinyl bromide (C2H3Br). The photoabsorption spectrum was measured using synchrotron radiation and was investigated in detail between 5.0 and 12.0 eV photon energy revealing many previously unobserved structures. These features were analyzed in terms of valence to virtual valence transitions and Rydberg series. The examination of the three Rydberg series converging towards the first ionization threshold (2a"->ns, 2a"->np and 2a"->nd) leads to wavenumbers of 335+/-30, 690+/-30 and 1305+/-30 cm-1. The vibrational wavenumbers of the progressions belonging to Rydberg series converging towards the second ionization threshold are 485+/-30 and 1145+/-50 cm-1. Ab initio calculations helped the assignment of the valence transitions and of the observed vibrational wave numbers in the Rydberg series. Constant Ionic State spectra were recorded for vibronic states corresponding to the first and the second electronic states of the ion. Their fine structures are assigned to the autoionization of Rydberg states. The autoionization decay of these Rydberg states is analyzed qualitatively in terms of the vibrational nature of the final ionic state. [less ▲]

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See detailComment j'explore ... les anomalies du metabolisme glucidique, de l'insulinosecretion et de la sensibilite a l'insuline avec une hyperglycemie provoquee par voie orale.
Luyckx, Françoise ULg; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 881-5

Oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes, impaired glucose tolerance or reactive hypoglycaemia. Simultaneous measurements of ... [more ▼]

Oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes, impaired glucose tolerance or reactive hypoglycaemia. Simultaneous measurements of plasma glucose and insulin levels also allow to derive indices of insulin secretion and insulin sensitivity. Whereas OGTT is not considered anymore as the first choice for the diagnosis of diabetes mellitus, it remains useful for studying abnormalities of glucose metabolism as well as of insulin secretion and insulin action. [less ▲]

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See detailProfil et épaisseur des mots : Kamau Brathwaite RêvHaïti
Pagnoulle, Christine ULg

in Palimpsestes (2000), 12

The article comments on the specifities of Brathwaite's use of language and typography and on the translator's attempt at retrieving them (the translator being also the author of the article).

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See detailA potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release
Lebrun, P.; Arkhammar, P.; Antoine, M.-H. et al

in Diabetologia (2000), 43

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See detailStudy of the Virulence of Five Strains of Amyxomatous Myxoma Virus in Crossbred New Zealand White/Californian Conventional Rabbits, with Evidence of Long-Term Testicular Infection in Recovered Animals
Marlier, Didier ULg; Mainil, Jacques ULg; Sulon, Joseph ULg et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 101-13

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by ... [more ▼]

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by inoculation of five groups of 10 crossbred New Zealand White/Californian conventional rabbits. A much more acute myxomatosis syndrome was produced in conventional rabbits than that reproduced previously in SPF animals. However, the main clinical signs were of the respiratory type. The MV strains MYX 254/95 and 801 appeared very virulent, killing all the inoculated animals. The strains MYX 217/95, MYX 555/94 and Saint Benoist were somewhat attenuated, killing only seven, six and six rabbits, respectively. Extensive lung lesions due to supervening bacterial infections were observed in 36 of the 39 rabbits that died. Lethality was found to be a better estimate of virulence than mean survival time. By 98 days after viral inoculation, all the surviving animals had completely recovered. At that time, they were immunosuppressed by treatment with adrenocorticotrophic hormone (ACTH) for 10 days to determine whether they still harboured the virus. After the ACTH treatment, eight of the 11 surviving rabbits showed clinical signs that resembled amyxomatous myxomatosis. All the virological examinations performed on naso-conjunctival exudate, on mononuclear cells, on eyelids and on ovaries remained negative but infectious virus was isolated from the testes of three of six surviving male rabbits. [less ▲]

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See detailThe increase of the ionospheric activity as measured by GPS
Warnant, René ULg; Pottiaux, Eric

in Earth, Planets, and Space [=EPS] (2000), 52(11), 1055-1060

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See detailStructure-activity relationships on adrenoceptors and imidazoline-preferring binding sites (I(1,2)-PBSs). Part 1: Weak intramolecular H-bond and conformational flexibility in a new I1-PBS-selective imidazoline analogue, trans1-(4',5'-dihydro-1'H-imidazol-2'-yl)methyl-2-hydroxyindane (PMS 952).
Ye, Hai Fen; Dive, Georges ULg; Dehareng, Dominique ULg et al

in Bioorganic & Medicinal Chemistry (2000), 8(8), 1861-9

The highly selective I1-PBS imidazoline analogue PMS 952 has been selected to study the incidence of intramolecular hydrogen bond and molecular flexibility on its biological activity. On one hand, the ... [more ▼]

The highly selective I1-PBS imidazoline analogue PMS 952 has been selected to study the incidence of intramolecular hydrogen bond and molecular flexibility on its biological activity. On one hand, the weak energy difference between three calculated conformers does not support the stabilization of one conformer by an internal hydrogen bond. The 3-D electrostatic map confirms this feature and the solvent effect does not significantly modify the relative energy of these conformers. On the other hand, the conformational spaces of the neutral and ionized forms present a great number of equilibrium structures, in a short energetic range (20 Kcal). The results are representative of an exceptional conformational flexibility due to a cooperative effect between several parts of the molecule. [less ▲]

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See detailConstruction and characterization of an ovine BAC contig spanning the callipyge locus.
SEGERS, Karin ULg; Vaiman, D.; Berghmans, S. et al

in Animal Genetics (2000), 31(6), 352-9

We describe the construction of an ovine BAC contig spanning a 4.6 centimorgan (cM) chromosome segment known to contain the callipyge (CLPG) locus. The contig comprises 21 ovine BAC clones jointly ... [more ▼]

We describe the construction of an ovine BAC contig spanning a 4.6 centimorgan (cM) chromosome segment known to contain the callipyge (CLPG) locus. The contig comprises 21 ovine BAC clones jointly covering approximately 900 kilobases (Kb). Two gaps in the BAC contig, spanning 10 and 7.5 Kb, respectively, were bridged by long range PCR. The corresponding chromosome region was shown to be characterized by an unusually low Kb to cM ratio (164 Kb/cM) and a high density of Not1 sites (1:126 Kb) possibly reflecting a high gene density in the corresponding chromosome region. Equivalent amplification of 64 sequence tagged sites spanning the corresponding region from homozygous +/+ and CLPG/CLPG individuals disproves the hypothesis of a major deletion causing the CLPG mutation. [less ▲]

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See detailMutation in exon 5 of bovine prolactin gene is not associated with milk traits in Holstein bulls.
Parmentier, Isabelle; Gengler, Nicolas ULg; Laliberte, P. et al

in Journal of Animal Science (2000), 78(Suppl 1),

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See detailProgress in Arabidopsis genome sequencing and functionnal genomics.
Wambutt, R.; Portetelle, Daniel ULg; Vandenbol, Micheline ULg et al

in Journal of Biotechnology (2000), 78

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See detailLes surcoûts collectifs de la désurbanisation : quand la mobilité dessine la ville
Halleux, Jean-Marie ULg

in La Cemathèque (2000), (4), 8-11

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See detailLa carte des émotions : exercice structuré
Faulx, Daniel ULg

in Cahiers Internationaux de Psychologie Sociale (2000), (45), 98-103

Cet outil permet d'identifier et d'analyser la présence, la circulation et la gestion des émotions au sein d'une équipe de travail ou d'un groupe. Il propose différents modes de mesure de l'émotion au ... [more ▼]

Cet outil permet d'identifier et d'analyser la présence, la circulation et la gestion des émotions au sein d'une équipe de travail ou d'un groupe. Il propose différents modes de mesure de l'émotion au sein des groupes, et constitue à ce titre à la fois un outil de mesure et d'intervention ou de développement. [less ▲]

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See detailIdentification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii.
Jarmuszkiwicz, W.; Milani, G.; Fortes, F. et al

in FEBS Letters (2000), 467

An uncoupling protein (UCP) was identified in mitochondria from Candida parapsilosis (CpUCP), a non-fermentative parasitic yeast. CpUCP was immunodetected using polyclonal antibodies raised against plant ... [more ▼]

An uncoupling protein (UCP) was identified in mitochondria from Candida parapsilosis (CpUCP), a non-fermentative parasitic yeast. CpUCP was immunodetected using polyclonal antibodies raised against plant UCP. Activity of CpUCP, investigated in mitochondria depleted of free fatty acids, was stimulated by linoleic acid (LA) and inhibited by GTP. Activity of CpUCP enhanced state 4 respiration by decreasing DeltaPsi and lowered the ADP/O ratio. Thus, it was able to divert energy from oxidative phosphorylation. The voltage dependence of electron flux indicated that LA had a pure protonophoretic effect. The discovery of CpUCP proves that UCP-like proteins occur in the four eukaryotic kingdoms: animals, plants, fungi and protists. [less ▲]

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See detailA random matrix model for color superconductivity at zero chemical potential
Vanderheyden, Benoît ULg; Jackson, A. D.

in Physical Review. D : Particles and Fields (2000), 61(7), 076004

We discuss random matrix models for the spontaneous breaking of both chiral and color symmetries at zero chemical potential and finite temperature. Exploring different Lorentz and gauge symmetric color ... [more ▼]

We discuss random matrix models for the spontaneous breaking of both chiral and color symmetries at zero chemical potential and finite temperature. Exploring different Lorentz and gauge symmetric color structures of the random matrix interactions, we find that spontaneous chiral symmetry breaking is always thermodynamically preferred over diquark condensation. Stable diquark condensates appear only as SU(2) rotated chiral condensates, which do not represent an independent thermodynamic phase. Our analysis is based on general symmetry arguments and hence suggests that no stable and independent diquark phase can form in QCD with two flavors at zero quark chemical potential. [less ▲]

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See detailPratique de la mise en observation psychiatrique
Boxho, Philippe ULg

in Bulletin d'information du Conseil provincial de Liège de l'Ordre des Médecins (2000)

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See detailMotivations et apports d'une prise en charge ambulatoire pluridisciplinaire de la santé des adolescents
Bourguignon, Jean-Pierre ULg; Grignard, Sophie ULg; Glowacz, Fabienne ULg et al

in Bulletin d'Education du Patient à sa Maladie (2000), 19(3), 126-129

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils ... [more ▼]

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils consultent peu à ce sujet. En particulier, ils évoquent rarement les aspects psychosociaux des problèmes auxquels ils sont confrontés. Ils fonctionnent dans le clivage entre somatique et psychologique bien que ces deux aspects soient indissociables. Les adolescents sont souvent amenés en consultation par d’autres, dont les parents. Un travail d’identification de la demande réelle de l’adolescent est donc nécessaire pour que celui-ci puisse se mobiliser vers une prise en charge. La confidentialité est cruciale de même que le respect de l’adolescent, ainsi que la reconnaissance de ses craintes et des limites qu’il met à l’accès aux informations par l’anamnèse et l’examen clinique. Il appartient au médecin de lire la demande de l’adolescent dans un double registre, à la fois somatique et psychique et de resituer cette demande dans le contexte de vie particulier à l’adolescent. Aussi, la lecture de la demande intégrera non seulement les problèmes invoqués par l’adolescent mais aussi ceux relevés par l’anamnèse et l’examen clinique. Une telle lecture peut prendre du temps pour les intervenants de santé mais aussi pour l’adolescent, avant qu’il n’aboutisse à l’émergence de sa demande et, dès lors, à une demande de prise en charge. Celle-ci devra parfois faire appel à une équipe spécifique et pluridisciplinaire telle que celle où collaborent les auteurs du présent article, au Centre de Santé de l’Adolescent à Liège. [less ▲]

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See detailLe principe de precaution et l'obligation d'action medicale
Foidart, Jean-Michel ULg

in Bulletin de l'Académie Nationale de Médecine (2000), 184(5), 937-43943-4

Since Antiquity, medicine has been based upon the principle of prudence. In recent years, the principle of precaution has stolen over the medical conscience and has especially been forced on doctors under ... [more ▼]

Since Antiquity, medicine has been based upon the principle of prudence. In recent years, the principle of precaution has stolen over the medical conscience and has especially been forced on doctors under pressure from a Society searching for a new Holy Grail; the utopia of zero risk and the fear for magical power of an omnipotent medicine. The principle of precaution should be capable of warding off all these evils of techno-scientific progress applied to Health. Thus, in a few years, a new norm has established itself first for the environment but which has today extended to the domain of medical decisions. It is essential that the medical authorities attract the attention of politics and of the judiciary to the dangers of blindly transposing the principle of precaution in ecology to the world of medicine. The risks of deviation are numerous, the eventual perverse effects would be detrimental to patients and health security would be endangered by paralysis and conservatism. Medicine is neither the Art of Curing nor the Art of not Harming, ... it is the Art of Caring! ... [less ▲]

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See detailHartree-Fock instabilities and electronic properties
Dehareng, Dominique ULg; Dive, Georges ULg

in Journal of Computational Chemistry (2000), 21(6), 483-504

Hartree-Fock instabilities are investigated for about 80 compounds, from acetylene to mivazerol (27 atoms) and a cluster of 18 water molecules, within a double zeta basis set. For most conjugated systems ... [more ▼]

Hartree-Fock instabilities are investigated for about 80 compounds, from acetylene to mivazerol (27 atoms) and a cluster of 18 water molecules, within a double zeta basis set. For most conjugated systems, the restricted Hartree-Fock wave function of the singlet fundamental state presents an external or so-called triplet instability. This behavior is studied in relation with the electronic correlation, the vicinity of the triplet and singlet excited states, the electronic delocalization linked with resonance, the nature of eventual heteroatoms, and the size of the systems. The case of antiaromatic systems is different, because they may present a very large internal Hartree-Fock instability. Furthermore, the violation of Hund's rule, observed for these compounds, is put in relation with the fact that the high symmetry structure in its singlet state has no feature of a diradical-like species. It appears that the triplet Hartree-Fock instability is directly related with the spin properties of nonnull orbital angular momentum electronic systems. (C) 2000 John Wiley & Sons, Inc. [less ▲]

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See detailPersistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Haematologica (2000), 85(6), 613-8

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve ... [more ▼]

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve clinical outcome. Therefore, we studied the value of (18)F-FDG PET for early evaluation of response in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We studied 28 patients by (18)F-FDG PET after a median of 3 cycles of polychemotherapy. The presence or absence of abnormal (18)F-FDG uptake was correlated to clinical outcome (median follow-up: 17.5 months, range 4-47 months). RESULTS: Five of 28 patients still had increased (18)F-FDG uptake in one or more sites previously shown to be involved by lymphoma at baseline evaluation. Only one of these five patients entered complete remission (CR), whereas among the 23 patients with negative (18)F-FDG PET studies, two died of toxicity during chemotherapy and all the others entered clinical CR (p<0.00001). All five patients with and 7/21 patients without residual abnormal (18)F-FDG uptake relapsed or reprogressed (positive predictive value for relapse: 100%, negative predictive value: 67%). By Kaplan-Meier analysis, progression-free survival (PFS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive patients and 81+/-9% and 62+/-12% for (18)F-FDG PET negative patients (p=0.0001). Overall survival (OS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive and 87+/-7% and 68+/-11% for (18)F-FDG PET negative patients (p<0.0001). INTERPRETATION AND CONCLUSIONS: Persistent tumoral (18)F-FDG uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL. Further studies are warranted to determine whether (18)F-FDG PET has a predictive value independent from conventional prognostic factors. However, the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient. Earlier evaluation after only one cycle of chemotherapy and quantitative analysis might increase the sensitivity of 18F-FDG PET is predicting treatment failure. [less ▲]

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See detailEffect of corn steep liquor supplementation and scale up on Lactococcus starter production.
Hamdi, M.; Hamza, S.; Mtimet, N. et al

in Bioprocess and Biosystems Engineering (2000), 22

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See detailL'entérotoxémie bovine en Belgique. II. Epizootiologie élémentaire et pathologie descriptive.
Manteca, Christophe; Daube, Georges ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (2000), 145

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See detailLes aspects precliniques des therapeutiques anti-angiogenes
Noël, Agnès ULg; Foidart, Jean-Michel ULg

in Bulletin de l'Académie Nationale de Médecine (2000), 184(3), 569-77578

Tumor angiogenesis is one of the most important fields of cancer research. It is important to identify the putative targets for antiangiogenic strategies. To date, a number of angiogenic agents have been ... [more ▼]

Tumor angiogenesis is one of the most important fields of cancer research. It is important to identify the putative targets for antiangiogenic strategies. To date, a number of angiogenic agents have been identified: bFGF, the different VEGF isoforms, integrins, proteases (matrix metalloproteases and serine proteases),... Furthermore, several physiological anti-angiogenic agents have been isolated such as endostatin, angiostatin, 16 K prolactin,.... The recent development of mice deficient for one gene involved during angiogenesis gives a new insight into the molecular mechanisms regulating this process. It leads to the identification of plasminogen activator inhibitor-1 or PAI-1 as a new target for tumor treatment. Although, PAI-1 is very attractive as a target for new therapeutic strategies, a better understanding of its mechanism of action is needed urgently. [less ▲]

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See detailCroissance et rentabilité des plantations de douglas en Région wallonne.
Lejeune, Philippe ULg; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(1), 6-15

Considéré par beaucoup de sylviculteurs européens comme une essence d'avenir, le douglas (Pseudotsuga menziesii (Mirb.) FRANCO) se caractérise avant tout par un très grand potentiel de productivité ... [more ▼]

Considéré par beaucoup de sylviculteurs européens comme une essence d'avenir, le douglas (Pseudotsuga menziesii (Mirb.) FRANCO) se caractérise avant tout par un très grand potentiel de productivité assorti de propriétés mécaniques remarquables ( de CHAMPS et DEMACQ, 1996). Encore faut-il que le sylviculteur identifie clairement l'itinéraire sylvicole à assigner à ces peuplements sur des bases aussi objectives que possibles. Les critères devant orienter ce choix relèvent autant de l'adéquation essence-station qui est un préalable à leur installation, que des exigences du marché ou encore, dans le contexte d'une sylviculture de production, de la rentabilité financière du projet sylvicole retenu. L'objectif de la présente étude est d'évaluer de manière générale la rentabilité financière potentielle d'une plantation de douglas en Wallonie. Au travers d'une comparaison de quelques scénarios sylvicoles représentatifs des grandes tendances en matière de culture de cette essence, nous essaierons également d'apprécier l'impact du choix sylvicole, non seulement sur la rentabilité du projet, mais également sur les caractéristiques dendrométriques, voire technologiques, des peuplements ainsi façonnés. Une telle démarche de comparaison de scénarios sylvicoles implique avant tout de disposer d'un outil capable de prédire, d'une manière aussi fiable que possible, l'évolution sur plusieurs décennies de peuplements forestiers soumis à un traitement sylvicole donné. Il convient également de bien préciser la démarche retenue pour effectuer les comparaisons de rentabilité financière en insistant sur l'interprétation à donner à celles-ci. Nous présenterons tout d'abord le modèle de croissance que nous avons utilisé dans le cadre de cette étude (paragraphe 2) et préciserons les modalités d'évaluation financière mises en oeuvre (paragraphe 3). Nous détaillerons ensuite, sur base des principaux paramètres sylvicoles (révolution, densité de plantation, calendrier et nature des éclaircies), les différents scénarios considérés dans cette comparaison (paragraphe 4), ainsi que leurs performances respectives (paragraphe 5). Nous conclurons enfin sur la portée des résultats enregistrés et les limitations d'une telle étude (paragraphe 6). [less ▲]

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See detailReactions involving inorganic compounds
Krief, A.; Delmotte, C.; Colaux, Catherine ULg

in Pure & Applied Chemistry (2000), 72(9), 1709-1713

Selenium chemistry became, over the last 30 years, particularly useful for synthetic organic chemistry [1]. Inorganic as well as organic selenium compounds allow transformation which otherwise cannot be ... [more ▼]

Selenium chemistry became, over the last 30 years, particularly useful for synthetic organic chemistry [1]. Inorganic as well as organic selenium compounds allow transformation which otherwise cannot be done or require much more drastic conditions to proceed. We have over the last 25 years explored the reactivity of elemental selenium as well as its inorganic and organic derivatives. We report here our recent finding concerning (i) organic diselenols and -diselenolates and (ii) the role of selenoxides in the enantioselective dihydroxylation of C,C double bonds using catalytic amounts of osmium tetroxide. [less ▲]

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See detailInfluence of colors on habituation of visual evoked potentials in patients with migraine with aura and in healthy volunteers.
Afra, J; Ambrosini, A; Génicot, Roger ULg et al

in Headache (2000), 40(1), 36-40

OBJECTIVE: To investigate whether colored glasses influence the habituation of visual evoked potentials. BACKGROUND: We have previously shown that during pattern-reversal stimulations lasting 2 minutes ... [more ▼]

OBJECTIVE: To investigate whether colored glasses influence the habituation of visual evoked potentials. BACKGROUND: We have previously shown that during pattern-reversal stimulations lasting 2 minutes the amplitude of the visual evoked potential increases in migraine with and without aura between attacks, whereas it decreases in healthy volunteers. Red light was found to increase visually evoked EEG fast activity only in children with migraine with aura. Wearing rose-tinted glasses for 4 months decreased attack frequency in parallel with a reduction of the visually evoked EEG fast activity. METHODS: We compared the change in amplitude of the visual evoked potential using five different tinted glasses in 12 patients with migraine with aura and in 10 healthy volunteers. During continuous stimulation at 3.1 Hz, five blocks of 50 responses were sequentially averaged using red, yellow, green, blue, and grey glasses and without glasses in a random order and analyzed in terms of latencies and N1-P1 amplitudes. Amplitude changes were calculated for each block by comparison with the first block in every condition and analyzed statistically using Zerbe's method. RESULTS: In healthy volunteers, the visual evoked potential amplitude increased with red glasses compared to without glasses (P = .05) or with green glasses (P = .03). In patients with migraine with aura, no significant difference was detected using colored glasses. Our findings in healthy volunteers are in line with earlier reports of increased excitability of the human visual cortex when exposed to red light. The lack of such a pattern in patients with migraine with aura suggests that the visual cortex is interictally hypoexcitable rather than hyperexcitable, which is consistent with studies of transcranial magnetic stimulation. [less ▲]

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See detailFeasability of monitoring neutrophils'migration into the lung with immunoscintigraphy: preliminary study
Votion, Dominique ULg; Harmegnies, N. F.; Lekeux, Pierre ULg

in European Journal of Nuclear Medicine (2000), 27

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See detailLe courant excito-moteur: aspects scientifiques et rééducatifs
Vanderthommen, Marc ULg

in Kine Acta (2000), 356

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See detailThe use of conducting polymers as cathodes for the electrochemical deposition of magnetic transition metal/rare alloys
Martinot, Lucien; Leroy, Delphine ULg; Zhan, H. et al

in Journal of Materials Chemistry (2000), 10(3), 729-735

We report the electrodeposition of Cu and Ni in aqueous solutions together with the deposition of lanthanides (Gd, Sm, Dy, Tb) and amorphous magnetic alloys of lanthanides with transition metals (Fe, Co ... [more ▼]

We report the electrodeposition of Cu and Ni in aqueous solutions together with the deposition of lanthanides (Gd, Sm, Dy, Tb) and amorphous magnetic alloys of lanthanides with transition metals (Fe, Co) onto various polymer cathodes in formamide solutions. We used conducting polymers (polypyrrole, PPy; polyethylenedioxythiophene, PEDOT) sprayed on different substrates and in addition composite materials based on carbon black (CB) mixed either with polyethylene (PE) or with polycarbonate (PC). In the latter case, the conducting material is easily shaped out in various forms. When deposited on some of these substrates, the alloys appear as an interesting material for magneto-optic recording. The electrochemical process was used for the preparation of Gd/Co and Dy/Fe alloys for which the measured coercitive fields ranged from 250–300 Oe (Dy/Fe) to about 350 Oe (Gd/Fe). We demonstrated also the feasibility of an additional electrografting of a transparent protective layer of polyacrylonitrile (PAN) in order to avoid the corrosion of the alloys by the atmosphere. [less ▲]

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See detailPotato tubers exhibit both homolytic and heterolytic hydroperoxide fatty acid-cleaving activities
Fauconnier, Marie-Laure ULg; Delcarte, J.; Hoyaux, P. et al

in Biochemical Society Transactions (2000), 28(6), 853-855

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See detailA novel messenger ribonucleic acid homologous to human MAGE-D is strongly expressed in rat Sertoli cells and weakly in Leydig cells and is regulated by follitropin, lutropin, and prolactin.
Hennuy, Benoît ULg; Reiter, E.; Cornet, Anne ULg et al

in Endocrinology (2000), 141(10), 3821-31

We have cloned a novel complementary DNA whose expression was decreased in rat Sertoli cell cultures after treatment with FSH. This complementary DNA encodes a protein of 570 amino acids and shares 92 ... [more ▼]

We have cloned a novel complementary DNA whose expression was decreased in rat Sertoli cell cultures after treatment with FSH. This complementary DNA encodes a protein of 570 amino acids and shares 92% homology with the human MAGE-D protein. In contrast to other MAGE genes (A, B, or C), we have shown that MAGE-D expression was ubiquitous in healthy rat tissues. In the seminiferous tubules, the MAGE-D was expressed in Sertoli cells but not in germ cells as demonstrated by RT-PCR and in situ hybridization, whereas for the other MAGE genes, expression has been shown to be restricted to germ cells. Interestingly, MAGE-D was also detected for the first time in the female gonad by Northern blotting. In MLTC-1 cells (mouse Leydig tumor cell line-1), LH and PRL stimulated MAGE-D expression. Using hypophysectomized rats, it was confirmed that FSH decreased MAGE-D expression, whereas LH and PRL increased MAGE-D messenger RNA level in the whole testis most probably through a direct action on Leydig cells. As MAGE-D is present in both the seminiferous compartment and interstitium and hormonally regulated in each, it is possible that it has specific functions in each compartment during the development and the maintenance of the testis. [less ▲]

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See detailApproches thérapeutiques du cancer ovarien
Bonnet, Christophe ULg; Jerusalem, Guy ULg; Bours, Vincent ULg et al

in Médecine et Hygiène (2000), 58

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See detailOestrogenotherapie apres la menopause et protection cardio-vasculaire: discordance entre les observations epidemiologiques et les resultats d'essais therapeutiques.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 886-8

Based upon the positive results of a large epidemiological study and the negative results of an interventional clinical trial recently published in the New England Journal of Medicine, we will briefly ... [more ▼]

Based upon the positive results of a large epidemiological study and the negative results of an interventional clinical trial recently published in the New England Journal of Medicine, we will briefly discuss the impact of estrogen replacement therapy on the protection against coronary heart disease in postmenopausal women. [less ▲]

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See detailBauhinia L. in the Philippine Islands: aspects of diversity and vegetation units
Ruelle, S.; Malaisse, François ULg

in Geo-Eco-Trop (2000), 23(1-4), 49-62

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See detailLa géométrie de la spatiocarte : corrections et validations, Spatiocartographie
Cornélis, Bernard; Billen, Roland ULg

in Bulletin de la Société Géographique de Liège (2000), (38(1)), 25-43

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See detailSomatic embryogenesis of Panax ginseng in liquid cultures: a role for polyamines and their metabolic pathways
Kevers, Claire ULg; Le Gal, Nathalie; Monteiro, Marta et al

in Plant Growth Regulation (2000), 31(3), 209-214

A callus with embryogenic capacity was generated from root sections of Panax ginseng and used as an inoculum source for embryogenic liquid cultures in a three-step process: - a suspension culture of cell ... [more ▼]

A callus with embryogenic capacity was generated from root sections of Panax ginseng and used as an inoculum source for embryogenic liquid cultures in a three-step process: - a suspension culture of cell aggregates in the presence of an auxin/cytokinin mixture, - an induction medium containing auxin only (for 5 to 30 days), - a regeneration medium containing cytokinin only (for one month). Up to 25 embryos were recovered per 2.5 g of aggregates in these conditions. Incorporation of polyamines or their precursors arginine and ornithine into either the induction or regeneration media increased the number of embryos produced by up to 4 times. Inhibitors of both biosynthesis and biodegradation of polyamines reduced the number of embryos. These results support earlier findings of the role of polyamines in the process of somatic embryogenesis. The success of these liquid cultures opens up the possibility of producing somatic embryos of Panax ginseng in bioreactors. [less ▲]

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See detailRelative impact of a seagrass bed and its adjacent epilithic algal community in consumer diets
Lepoint, Gilles ULg; Nyssen, Fabienne ULg; Gobert, Sylvie ULg et al

in Marine Biology (2000), 136

The aim of this work was to identify and compare, using nitrogen and carbon stable isotope data, the food sources supporting consumer communities in a Mediterranean seagrass bed (Gulf of Calvi, Corsica ... [more ▼]

The aim of this work was to identify and compare, using nitrogen and carbon stable isotope data, the food sources supporting consumer communities in a Mediterranean seagrass bed (Gulf of Calvi, Corsica) with those in an adjacent epilithic algal dominated community. Isotopic data for consumers are not significantly different in the two communities. Particulate matter and algal material (seagrass epiflora and dominant epilithic macroalgae) appear to be the main food sources in both communities. Generally, the 13C of animals suggests that the seagrass Posidonia oceanica (L.) Delile represents only a minor component of their diet or of the diet of their prey, but the occurrence of a mixed diet is not excluded. P.oceanica dominates the diet of only of few species, among which holothurians appear as key components in the cycling of seagrass material. [less ▲]

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See detailLe point des connaissances sur les entérites à Escherichia coli chez le veau
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2000), 144

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See detailMechanics of the Respiratory System in Healthy Newborn Calves Using Impulse Oscillometry
Uystepruyst, Christophe; Reinhold, Petra; Coghe, Joost et al

in Research in Veterinary Science (2000), 68(1), 47-55

Arterial blood gases, acid-base balance and respiratory function tests using impulse oscillometry (IOS) were performed on 40 clinically healthy newborn calves during the first 24 hours of life to evaluate ... [more ▼]

Arterial blood gases, acid-base balance and respiratory function tests using impulse oscillometry (IOS) were performed on 40 clinically healthy newborn calves during the first 24 hours of life to evaluate their respiratory adaptation to extrauterine life. Gas exchange efficiency of the lung was significantly improved with time and was accompanied by the correction of the mixed acidosis observed at birth and by significant changes in respiratory mechanics. Major changes were detected within the first 6 hours. The significant decrease in resistance (R) and the increase in reactance (X) with time, demonstrate the improvement in respiratory mechanics of both upper and lower airways, and reflect the increase in lung volume, the improved lung tissue elasticity and/or distribution of the ventilation. Respiratory mechanical, arterial blood gases and acid-base balance data provided in this study describe a successful respiratory adaptation to extrauterine life in healthy newborn calves. [less ▲]

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See detailEfficiency measurement, multiple-output technologies and distance functions: with application to European Railways
Coelli, Tim; Perelman, Sergio ULg

in Applied Economics (2000), (32), 1967-1976

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in ... [more ▼]

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in a multiple-output industry using econometric methods one would usually either: (a) aggregate outputs into a single index of output (e.g., total revenue or a multilateral Tornqvist output index); or (b) attempt to model the technology using a dual cost function. The first of these methods require that output prices be observable (and reflect revenue maximising behaviour), while the latter approach requires an assumption of cost-minimising behaviour. There are a number of instances, however, when neither of these requirements are met (the public sector contains many examples). In this study we outline the recently developed distance function solution to the multi-output problem. The method is illustrated using data on European railways. Output-orientated, input-orientated and constant returns to scale distance functions are estimated using corrected ordinary least squares. The distance function estimates are also compared with production function estimates involving aggregate output measures. These comparisons indicate that, for the case of European railways, a production function involving a multilateral Tornqvist output index exhibits substantially less aggregation bias relative to a production function that uses total revenue as a measure of aggregate output. [less ▲]

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See detailAb initio study of organic mixed valency
Dehareng, Dominique ULg; Dive, Georges ULg; Moradpour, Alec

in International Journal of Quantum Chemistry (2000), 76(4), 552-573

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by ... [more ▼]

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by full geometry optimization At both nuclear arrangements, mostly found as being minima in the symmetry-restrained Hartree-Fock framework, excitation energies were calculated through the expansion of the wave function on single electronic excitations of the Hart ee-Fock fundamental determinant and at the unrestricted Hartree-Fock or at the multiconfigurational self consistent field levels. Few calculations were also performed by taking into account some part of the electronic correlation. Except for N,N,N',N'-tetramethyl p-phenylenediamine, all the studied compounds are localized stable cations, at the symmetry-restrained Hartree-Fock level. However, the reoptimization of their wave function changes this observation since only three of them seem to conserve a localized stable conformation. Most of the studied systems are characterized by one or two excited electronic states very dose to the fundamental one and should thus present an unresolved broadened first absorption band in the near-infrared region These features are in agreement with the available experimental data. Strong Hartree-Fock instabilities are found for the delocalized structure and put in relation with the existence of the large nonadiabatic coupling in this conformational region. The solvent influence is discussed in the Onsager dipolar reaction field framework. (C) 2000 John Wiley & Sons, Inc. [less ▲]

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See detailTEP et tumeurs endocrines
Rigo, Pierre ULg; Belhocine, Tarik; Hustinx, Roland ULg et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2000), 24(5), 275-282

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les ... [more ▼]

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les tumeurs neuroendocrines, gastroentéropancréatiques et carcinoïdes, sont également analysées. Habituellement, les tumeurs différenciées ayant une faible activité métabolique et proliférative, elles ne fixent que peu le FDG. Dans l'évaluation des tumeurs endocrines, la TEP au FDG n'intervient en général pas en première intention mais elle joue un rôle complémentaire d'autres scintigraphies spécifiques. [less ▲]

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See detailHistologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Qu, Jianping et al

in Fertility and Sterility (2000), 74(1), 122-129

Objective: To compare histologic and ultrastructural characteristics of fresh and frozen-thawed human ovarian cortical tissue grafted into nude mice. Design: Experimental prospective study. Setting: An ... [more ▼]

Objective: To compare histologic and ultrastructural characteristics of fresh and frozen-thawed human ovarian cortical tissue grafted into nude mice. Design: Experimental prospective study. Setting: An academic research environment. Patient(s): Ovarian biopsy specimens were obtained from 13 women undergoing laparoscopy for tubal ligation or infertility. Animal(s): Forty nude mice. Intervention(s): A minilaparotomy was performed to place fresh and frozen-thawed ovarian grafts subcutaneously (sc) or intraperitoneally (ip). Removal of the ovarian grafts was performed at 24 days. Main Outcome Measure(s): [1] the follicular population, [2] fibrosis, [3] vascularization of the grafted tissue, and [4] ultrastructural evaluation. Result(s): A greater fibrosis relative surface area was noted in frozen-thawed transplanted tissue than in fresh transplants. Regardless of this fibrosis, a similar follicular density was observed in fresh and frozen-thawed ovarian tissue 24 days after transplantation. Active angiogenesis was proved by both immunohistochemical study of the vascular endothelial growth factor and morphometric study of the vascular network. Normal ultrastructural characteristics were noted in frozen-thawed ovarian biopsies. Conclusion(s): Angiogenesis allows implantation of the graft even if it has been cryopreserved and thawed similarly to implantation of fresh tissue. The greater fibrosis observed in grafts after cryopreservation and implantation does not seem to affect the primordial and primary ovocyte population and their ultrastructural characteristics, but further studies must be conducted to prove that after cryopreservation and transplantation, ovocytes may achieve full maturation and fertilization. [less ▲]

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See detailMicropore size distributions of activated carbons
Blacher, Silvia ULg; Sahouli, Bendida; Heinrichs, Benoît ULg et al

in Langmuir (2000), 16(16), 6754-6756

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See detailIdentification Of Key Residues For Interaction Of Vasoactive Intestinal Peptide With Human Vpac(1) And Vpac(2) Receptors And Development Of A Highly Selective Vpac(1) Receptor Agonist - Alanine Scanning And Molecular Modeling Of The Peptide
Nicole, P.; Lins, Laurence ULg; Rouyer-Fessard, C. et al

in Journal of Biological Chemistry (2000), 275(31), 24003-12

The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2). Solid-phase syntheses of VIP analogs in which each amino acid has been changed to alanine (Ala scan ... [more ▼]

The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2). Solid-phase syntheses of VIP analogs in which each amino acid has been changed to alanine (Ala scan) or glycine was achieved and each analog was tested for: (i) three-dimensional structure by ab initio molecular modeling; (ii) ability to inhibit (125)I-VIP binding (K(i)) and to stimulate adenylyl cyclase activity (EC(50)) in membranes from cell clones stably expressing human recombinant VPAC(1) or VPAC(2) receptor. The data show that substituting residues at 14 positions out of 28 in VIP resulted in a >10-fold increase of K(i) or EC(50) at the VPAC(1) receptor. Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor. The interaction of the analogs with human VPAC(2) receptor is similar to that observed with VPAC(1) receptor, with three remarkable exceptions: substitution of Thr(11) and Asn(28) by alanine increased K(i) for binding to VPAC(2) receptor; substitution of Tyr(22) by alanine increased EC(50) for stimulating adenylyl cyclase activity through interaction with the VPAC(2) receptor. By combining 3 mutations at positions 11, 22, and 28, we developed the [Ala(11,22,28)]VIP analog which constitutes the first highly selective (>1,000-fold) human VPAC(1) receptor agonist derived from VIP ever described. [less ▲]

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See detailPathophysiology of a fall in arterial oxygen saturation during sputum induction.
Cataldo, Didier ULg

in CHEST (2000), 117(6), 1818-9

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See detailGonadal cryopreservation in the young patient with gynaecological malignancy.
Donnez, Jacques; GODIN, Pierre-Arnaud ULg; Qu, Jianping et al

in Current Opinion in Obstetrics & Gynecology (2000), 12(1), 1-9

For patients who are planning to have chemotherapy, radiotherapy or to undergo bilateral oophorectomy, the loss of ovarian function will result in premature ovarian menopause and loss of fertility. Embryo ... [more ▼]

For patients who are planning to have chemotherapy, radiotherapy or to undergo bilateral oophorectomy, the loss of ovarian function will result in premature ovarian menopause and loss of fertility. Embryo preservation is not an option for single women or married women because delaying treatment for at least 2 months of in-vitro fertilization cycles is inappropriate and may be life-threatening. This study reports on the indications for ovarian tissue cryobanking and the state of the art of this method in preserving fertility in women with iatrogenic premature menopause. [less ▲]

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See detailExpression of transforming growth factor-alpha, epidermal growth factor, and epidermal growth factor receptor in follicles of human ovarian tissue before and after cryopreservation.
Qu, Jian Ping; NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (2000), 74(1), 113-121

Objective: To study the expression of transforming growth factor-alpha (TGF-α), epidermal growth factor (EGF), and EGF receptor in follicles of human ovarian tissue. Design: A retrospective, controlled ... [more ▼]

Objective: To study the expression of transforming growth factor-alpha (TGF-α), epidermal growth factor (EGF), and EGF receptor in follicles of human ovarian tissue. Design: A retrospective, controlled comparative study. Setting: In vitro fertilization laboratory of a university hospital. Patient(s): Fifteen women with regular menstrual cycles who underwent laparoscopy and the biopsy of ovarian tissue. Intervention(s): Paraffin sections were prepared from ovarian tissues, followed by immunohistochemical staining of TGF-α, EGF, and EGF receptor. Main Outcome Measure(s): Immunostaining for TGF-α, EGF, and EGF receptor in follicles of fresh and frozen ovarian tissues. Result(s): Immunoreactivities for TGF-α and EGF receptor were observed simultaneously in the oocytes of primordial, primary, preantral, and antral follicles. Strong staining for TGF-α and EGF receptor was present in thecal cells. The TGF-α and EGF receptor was also expressed in some granulosa cells of primary to antral follicles. The EGF only stained weakly in the oocytes of primordial and primary follicles and in thecal cells. There was no difference in staining patterns for TGF-α, EGF, and EGF receptor between fresh and frozen ovarian tissues. Conclusion(s): The TGF-α and EGF receptor was expressed in primordial to antral follicles, indicating a role of TGF-α in regulating follicular development through binding to the EGF receptor. Freeze-thawing did not substantially alter immunoreactivites for TGF-α, EGF, and EGF receptor in frozen ovarian tissue. [less ▲]

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See detailHyperammonemia after high-dose chemotherapy and stem cell transplantation.
Frere, Pascale ULg; Canivet, Jean-Luc ULg; Gennigens, Christine ULg et al

in Bone Marrow Transplantation (2000), 26(3), 343-5

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the ... [more ▼]

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the possibility of this diagnosis in patients developing confusion and neurological degradation with respiratory alkalosis after intensive chemotherapy, could allow earlier treatment and perhaps improved survival. Possible mechanisms and potential therapies are discussed. With rapid recognition and treatment of the syndrome, the patient fully recovered. One and a half years later, she is still alive and well, on interferon for persisting myeloma. [less ▲]

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See detailMechanical properties of Al/Al2O3 nanolaminated films: correlation to microstructure
Ben Daia, M.; Aubert, P.; Labdi, S. et al

in Surface & Coatings Technology (2000), 125(1-3), 196-200

Wear resistance and the hardness of Al/Al2O3 nanolaminated films were investigated in this study. Monolithic films and multilayers were deposited on a silicon substrate with two different substrate ... [more ▼]

Wear resistance and the hardness of Al/Al2O3 nanolaminated films were investigated in this study. Monolithic films and multilayers were deposited on a silicon substrate with two different substrate temperatures: T-s= 25 degrees C and T-s= -90 degrees C. The period thickness of multilayers was lowering from 40 to 2 nm. From nanoindentation measurements, it appears that the hardness of multilayers has an intermediate value between those of metal (Al) and ceramic (Al2O3). The tribological test was conducted by the pin-on-disc method. The T-s=25 degrees C deposited multilayers, as well as single films, demonstrated poor wear resistance. The best wear resistance was obtained for multilayers deposited at the lowest substrate temperature (T-s= -90 degrees C). The results are ill good agreement with structural characterization. X-ray reflectometry demonstrated that the multilayer character of Al/Al2O3 is more pronounced for T-s= -90 degrees C. (C) 2000 Elsevier Science S.A. All rights reserved. [less ▲]

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See detailLe potentiel evoque cognitif P300 (I): aspects theorique et psychobiologique.
Hansenne, Michel ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2000), 30(4), 191-210

The P300 is a positive wave which arises when an attended stimulus is detected. Its parameters depend on a number of variables, in particular the subject's mental state, the task that has to be ... [more ▼]

The P300 is a positive wave which arises when an attended stimulus is detected. Its parameters depend on a number of variables, in particular the subject's mental state, the task that has to be accomplished, the significance of the stimulus, and the degree of attention. It can be recorded with accuracy, and the different stages of information processing can therefore be analyzed. The P300 wave shows the modifications in neuronal activity which take place during the cognitive process: P300 latency provides an indirect indication of the duration of the processes involved in stimulus discrimination while its amplitude, which is influenced by a number of variables, provides an index of the intensity of the energetic activation or arousal involved. The P300 wave consists of several components which reflect distinct information-processing events (P3a, P3b, P3e, P-SR, P-CR). According to the theoretical models, it is hypothesized that P300 could either represent the adaptation of the working memory to further environmental input ('context updating'), or indicate a closing process ('context closure') in information processing. As regards the physiological aspect of P300 and its association with cortical networks, various studies have suggested that several cortical generators of P300 may co-exist: the medial temporal lobe, the temporo-parietal junction, and the medial and lateral frontal lobe. Psychopharmacological studies have shown that different neurotransmitter systems are involved in the generation and modulation of P300, namely the cholinergic, noradrenergic, dopaminergic, serotoninergic and gabaergic systems. It appears that the noradrenergic agonists increase the amplitude of P300, dopaminergic agonists may have a biphasic effect (increase/reduction), while cholinergic antagonists and gabaergic agonists reduce P300 amplitude and prolong its latency. [less ▲]

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See detailBactériologie comparée des liquides de lavage pulmonaire obtenus par voie transtrachéale ou par voie nasotrachéale chez le veau
Schreiber, P.; Thomas, A.; Linden, Annick ULg et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailLa progression au sein de la narration en égyptien: Éléments d’une grammaire du texte
Winand, Jean ULg

in Bulletin de l’Institut Français d’Archéologie Orientale (2000), (100), 403-435

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See detailIn vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR).
Mouithys-Mickalad, Ange ULg; Zheng, S. X.; Deby-Dupont, G. P. et al

in Free Radical Research (2000), 33(5), 607-21

OBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory drugs (NSAIDS), we examined by chemiluminescence (CL) and electron spin resonance (ESR) their scavenging properties ... [more ▼]

OBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory drugs (NSAIDS), we examined by chemiluminescence (CL) and electron spin resonance (ESR) their scavenging properties towards lipid peroxides, hypochlorous acid and peroxynitrite. METHODS: The antioxidant properties of nimesulide (NIM), 4-hydroxynimesulide (4-HONIM), aceclofenac (ACLO), 4-hydroxyaceclofenac (4-HOA-CLO), diclofenac (DICLO) and indomethacin (INDO) were tested on four different reactive oxygen species (ROS) generating systems: (I) phorbol-myristate acetate (PMA)-activated neutrophils, (II) Fe2+/ascorbate-induced lipid peroxidation, (III) HOCl-induced light emission, (IV) the kinetics of ONOO- decomposition followed by spectrophotometry. ROS production was monitored by luminol-enhanced CL or by ESR using two different spin traps. RESULTS: At 10 microM, ACLO, NIM, 4-HONIM, 4-HOA-CLO, and DICLO decreased luminol-enhanced CL generated by PMA-activated neutrophils. Inversely, INDO increased the luminol enhanced CL. Interestingly, hydroxylated metabolites were more potent antioxidants than the parent drugs. Furthermore, all drugs tested, excepted ACLO, lowered lipid peroxidation induced by Fe2+/ascorbate system. ACLO and DICLO, even at the highest concentration tested (100 microM), did not significantly lower HOCl induced CL, whereas the other drugs were potent scavengers. Finally, all the NSAIDS accelerated decomposition of ONOO-, suggesting a potential capacity of the molecules to scavenge peroxynitrite. CONCLUSION: The NSAIDs possess variable degrees of antioxidant activities, linked to their ability to react with HOCl, lipid peroxides or ONOO-. These antioxidant activities could offer interesting targeted side-effects in the treatment of joint inflammatory diseases. [less ▲]

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See detailIndicateurs de volume et de déplacement d'une structure isostatique : cas de la travée horizontale chargée verticalement
Samyn, Philippe; Latteur, Pierre ULg

in Bulletin n°7/12/2000 de la Classe des sciences de l'Académie royale de Belgique (2000)

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See detailLes orfèvres mosans devant l'histoire (XIe-XIIIe siècle)
George, Philippe ULg; Stiennon, Jacques ULg; Kupper, Jean-Louis ULg

in Bulletin de la Société Royale Le Vieux-Liège (2000)

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See detailMri Guided Percutaneous Abdominal Biopsy in a Closed Magnet: Assessment in an Animal Study
Fanchamps, J. M.; Kos, X.; Snaps, Frédéric ULg et al

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2000), 83(4), 149-52

MRI guided percutaneous abdominal biopsy was evaluated in an animal model, using a closed magnet and different types of needles. Thirty-six single pass biopsies were performed in 6 piglets with 6 types of ... [more ▼]

MRI guided percutaneous abdominal biopsy was evaluated in an animal model, using a closed magnet and different types of needles. Thirty-six single pass biopsies were performed in 6 piglets with 6 types of MR compatible needles. Virtual targets of a diameter of 2 cm were drawn on the images of the right and left lobe of the liver and the upper and lower poles of both kidneys. FMPSPGR sequences were applied during an apnea of 19 to 23 seconds in axial, sagittal, coronal or axial oblique planes using a closed 1.0 T magnet and the body coil. Piglets were autopsied 1 hour after the procedure. Mean duration of the procedure was 16.9 (11-37) minutes; mean number of acquisitions per procedure was 5.9 (3-12); mean number of redirections of the needle was 0.6 (0-4). Pathological samples from the liver and kidneys of good quality were obtained in 22/36 (72.2%) cases. A subcapsular hematoma was observed in 18/24 (75.0%) cases of renal biopsies and in 1/12 (8.3%) of hepatic biopsies. No statistically significant correlation could be established between duration of the procedure and site of biopsy and between the type of biopsy needle and complication (p = 0.18 to 0.85). In conclusion, MRI guided percutaneous needle biopsy in the abdomen is a reliable technique in piglets using a closed magnet. [less ▲]

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See detailHeadache tutorial.
Russell, M. B.; Nielsen, K. D.; Rasmussen, C. et al

in Studies in Health Technology & Informatics (2000), 78

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and ... [more ▼]

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and nomenclature. It is possible to move between the modules both vertically and horizontally. This paper concerns the headache tutorial. It consist of case records that the user can test his diagnostic abilities on. Each case record is subdivided into an interview by the physician, physical and neurological examination, laboratory test, sum of positive diagnostic elements, suggestions of diagnoses and management. A total of 12 case records are provided. The system will be available on a CD-ROM. [less ▲]

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See detailProtective Effects Of A Live Attenuated Bovine Leukaemia Virus Vaccine With Deletion In The R3 And G4 Genes
Reichert, M.; Cantor, Gh.; Willems, Luc ULg et al

in Journal of General Virology (2000), 81

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See detailEarly-stage endometriosis: adhesion and growth of human menstrual endometrium in nude mice
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Donnez, Jacques

in Fertility and Sterility (2000), 74(2), 306-12

Objective: To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. Design: Experimental prospective study. Setting: An academic research ... [more ▼]

Objective: To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. Design: Experimental prospective study. Setting: An academic research environment. Animals: Ten nude mice. Intervention(s): A minilaparotomy was performed to place fresh human menstrual endometrial samples in the peritoneal cavity. Removal of the transplants was performed successively on days 1, 3, and 5 by laparotomy. Main Outcome Measure(s): Adhesion of endometrial fragments and early stages of endometrial lesions was morphologically and immunohistochemically studied. Result(s): As early as day 1, stromal cells were found to be attached to the mesothelium. A progressive reorganization of epithelial and stromal cells into endometrial glands was observed. On day 5, cystic endometriotic lesions were characterized by more extensive proliferative activity in glandular cells and a higher VEGF score in stromal cells than that observed in previously removed transplants. Conclusion(s): Menstrual human endometrium is able to implant on intact mesothelium and to reorganize itself into structured glands and stroma under the influence of unknown factors. We suggest that stromal and glandular cells have two distinct roles: stromal cells are involved in the attachment process and glandular cells in the growth of the endometriotic lesion. [less ▲]

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See detailEndocardite végétante dans l’espèce équine : revue de littérature à partir de 2 cas cliniques
Amory, Hélène ULg; Christmann, U.; Cassart, Dominique ULg et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailThe unseen face of humanitarian crisis in eastern Democratic Republic of Congo: was nutritional relief properly targeted?
Porignon, Denis ULg; Katulanya, I.; Elongo, L. et al

in Journal of epidemiology and community health (2000), 54(1), 6-9

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic ... [more ▼]

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic Republic of Congo. DESIGN: Cross sectional surveys. SETTING: Temporary and other settlements, in the town of Goma and surrounding rural areas. SUBJECTS: Anthropometric indicators of nutritional status and presence or absence of oedema were measured among 5121 children aged 6 to 59 months recruited by cluster sampling with probability proportional to size, between June and August 1995. RESULTS: Children in all locations demonstrated a typical pattern of growth deficit relative to international reference. Prevalence of acute malnutrition (wt/ht < -2 Z score) was higher among children in the rural non-refugee populations (3.8 and 5.8%) than among those in the urban non-refugee populations (1.4%) or in the refugee population living in temporary settlements (1.7%). Presence of oedema was scarcely noticed in camps (0.4%) while it was a common observation at least in the most remote rural areas (10.1%). As compared with baseline data collected in 1989, there is evidence that nutritional status was worsening in rural non-refugee populations. CONCLUSIONS: Children living in the main town or in the refugee camps benefited the most from nutritional relief while those in the rural non-refugee areas were ignored. This is a worrying case of inequity in nutritional relief. [less ▲]

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See detailIncreased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies
Ribbens, Clio ULg; Andre, Béatrice ULg; Kaye, O. et al

in European Cytokine Network (2000), 11(4), 669-676

The assessment of cytokines and their soluble receptors in the synovial fluid (SF) of inflammatory arthropathies may be useful in studying pathogenetic and immunoregulatory mechanisms underlying different ... [more ▼]

The assessment of cytokines and their soluble receptors in the synovial fluid (SF) of inflammatory arthropathies may be useful in studying pathogenetic and immunoregulatory mechanisms underlying different diseases. The aim of this work was to study the cytokine network occurring in inflammatory arthropathies and to identify a cytokine profile which is characteristic of an immune-mediated synovitis. Levels of IL-12, as well as IL-4, IL-8, IL-10, IFN-gamma, sCD25, TNF-alpha and its soluble receptors were measured in the SF of various arthropathies, i.e. non-inflammatory arthropathies: "control" meniscus pathology (n = 21), osteoarthritis (n = 22) and chronic crystal arthritis (n = 9); a non-immune inflammatory arthropathy: acute crystal arthritis (n = 11); 2 immune inflammatory arthropathies: reactive arthritis (ReA) (n = 23) and rheumatoid arthritis (RA) (n = 44). SF levels of IL-10, TNF-alpha and sTNF-RII were found to be increased in the three inflammatory arthropathies compared to the "control" meniscus group. Within the inflammatory group, acute crystal arthritis was characterized by a significantly higher sTNF-RI/TNF-alpha ratio and ReA by a significantly lower sTNF-RII/TNF-alpha ratio compared to the two other diseases. The two immune arthropathies, RA and ReA, were characterized by increased SF levels of IL-12, sCD25 and of the sTNF-RII/sTNF-RI ratio. ReA differed however from RA by showing lower IL-8 and IL-4 levels, higher IFN-gamma levels and a higher IL-12/IL-10 ratio, suggesting a more prevalent Th1 profile in ReA SF. Our data indicate that the measurement of SF cytokines and soluble receptors may discriminate between each inflammatory arthropathy and might be useful in clinical practice. [less ▲]

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See detailThe cerebral protective effect of anaesthetics
HANS, Pol; BONHOMME, Vincent ULg

in Current Anaesthesia and Critical Care (2000), 11

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See detail1re campagne de fouille à Chagar Bazar (Syrie)
Tunca, Önhan ULg; McMahon, A.; Baghdo, Abd el-Massih

in Orient-Express 2000/1 (2000)

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See detailLithics in Belgium. Some Current Research Trends
Rots, Veerle ULg; Vermeersch, Pierre

in Lithic Technology (2000), 25(2), 76-79

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See detailNeurotoxicity Of The Putative Transmembrane Domain Of The Prion Protein
Haik, S.; Peyrin, Jm.; Lins, Laurence ULg et al

in Neurobiology of Disease (2000), 7(6), 644-56

It has been shown recently that the generation of an abnormal transmembrane form of the prion protein ((Ctm)PrP) is involved in the neurodegeneration process during inherited and infectious prion diseases ... [more ▼]

It has been shown recently that the generation of an abnormal transmembrane form of the prion protein ((Ctm)PrP) is involved in the neurodegeneration process during inherited and infectious prion diseases but a causative relationship has never been established. We wanted to know if and how the proposed transmembrane domain of PrP could induce neuronal dysfunction. Thus, we investigated the neurotoxic properties of two peptides whose sequences are encompassed within this domain. We show that PrP peptides 118-135 and 105-132 as well as an amidated more soluble peptide 105-132 induce the death of pure cortical neurons originating from normal and PrP knockout mice. This can be correlated with the high propensity of these peptides to insert stably into and to destabilize cell membranes. Through this study, we have identified a novel mechanism of neurotoxicity for PrP, which directly involves membrane perturbation; this mechanism is independent of fibril formation and probably corresponds to the effect of the transmembrane insertion of (Ctm)PrP. [less ▲]

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See detailLa probatio internetica
Vanbrabant, Bernard ULg

in Actualités du Droit (2000)

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