References of "Article"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 36301 to 36400 of 57607     359 360 361 362 363 364 365 366 367 368 369     Un incunable de l'archevêque François Buisseret (1549-1615) : Réserve Précieuse de la Bibliothèque royale à Bruxelles, Inc B 1277Adam, Renaud in Annales de la Société Archéologique de Namur (2003), 77Detailed reference viewed: 23 (1 ULiège) Une dermatite atopique sensible à un antifongique IBE.Franchimont, Claudine ; Pierard, Gérald in Dermatologie Actualité (2003), 75Detailed reference viewed: 31 (0 ULiège) Mycobacterium bovis meningitis in a cow with clinical signs of BSE.Roels, S.; Walravens, K.; Saegerman, Claude et alin Veterinary Record : Journal of the British Veterinary Association (2003), 152(26), 807-8Detailed reference viewed: 30 (0 ULiège) Les onychomycoses--echec et mat?Arrese Estrada, Jorge ; Quatresooz, Pascale ; Pierard, Claudine et alin Revue Médicale de Liège (2003), 58(9), 559-62According to individuals, onychomycoses or their treatments can be held in check. Some of the "promises" sometimes offered by pharmaceutical companies are not fully kept and hopes of cure may remain wild ... [more ▼]According to individuals, onychomycoses or their treatments can be held in check. Some of the "promises" sometimes offered by pharmaceutical companies are not fully kept and hopes of cure may remain wild. Some special therapeutic strategies should be employed in case of recalcitrant or recurrent onychomycosis. [less ▲]Detailed reference viewed: 63 (1 ULiège) Prolactin Suppresses Glucocorticoid-Induced Thymocyte Apoptosis in VivoKrishnan, Nithya; Thellin, Olivier ; Buckley, Donna J. et alin Endocrinology (2003), 144(5), 2102-2110The hypothesis that prolactin (PRL) functions as an immunomodulator was based on studies showing lymphocyte PRL receptors, and its effects on growth, differentiation, and apoptosis in lymphoid cells ... [more ▼]The hypothesis that prolactin (PRL) functions as an immunomodulator was based on studies showing lymphocyte PRL receptors, and its effects on growth, differentiation, and apoptosis in lymphoid cells. However, studies of PRL (PRL-/-) and PRL receptor knockout mice indicated that PRL was not required for immune system development or function under basal conditions. Because PRL maintains survival in glucocorticoid (GC)-treated Nb2-T lymphocytes in vitro, and PRL and GCs are elevated during stress, we investigated whether PRL protected T cells in vivo from GC-induced apoptosis. Adrenalectomized mice [PRL -/-, undetectable PRL; pituitary grafted PRL-/- (PRL-/-Graft), elevated PRL; and PRL+/-, normal PRL] were treated with dexamethasone (DEX) or PBS. Thymocytes and splenocytes were isolated and annexin V labeling of phosphatidylserine, DNA fragmentation, and caspase-3 activation were assessed as indices of apoptosis. Total thymocytes and CD4+ and CD8+ T cells obtained from DEX-treated PRL-/- mice exhibited significantly increased annexin V binding. In contrast, binding was not altered by DEX in PRL-/-Graft thymocytes. In addition, DEX induced classic DNA fragmentation in PRL-/- thymocytes. Elevated serum PRL reduced this effect. Thymocytes from DEX-treated PRL-/- mice exhibited increased caspase-3 activation, which was inhibited in cells from PRL-/-Graft mice. Finally, elevated expression of X-linked inhibitor of apoptosis, XIAP, was observed in thymi from DEX-treated PRL -/-Graft mice. This is the first demonstration that elevated PRL antagonizes apoptosis in thymocytes exposed to GCs in vivo. These observations suggest that, under conditions of increased GCs, such as during stress, elevated PRL functions physiologically to maintain survival and function of T-lymphocytes. [less ▲]Detailed reference viewed: 4 (0 ULiège) Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo.Humbert, Philippe G; Haftek, Marek; Creidi, Pierre et alin Experimental Dermatology (2003), 12(3), 237-44Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this ... [more ▼]Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this molecule as a potential candidate for use in the prevention and treatment of skin ageing. A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment. A double-blind, randomized trial was performed over a 6-month period, comparing the action of the vitamin C cream vs. excipient on photoaged skin. Clinical assessments included evaluation at the beginning and after 3 and 6 months of daily treatment. They were performed by the investigator and compared with the volunteer self assessment. Skin relief parameters were determined on silicone rubber replicas performed at the same time-points. Cutaneous biopsies were obtained at the end of the trial and investigated using immunohistochemistry and electron microscopy. Clinical examination by a dermatologist as well as self-assessment by the volunteers disclosed a significant improvement, in terms of the 'global score', on the vitamin C-treated side compared with the control. A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and well-tolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing. [less ▲]Detailed reference viewed: 183 (1 ULiège) Magnetic fabrics in the Holum granite (Vest-Agder, southernmost Norway): implications for the late evolution of the Sveconorwegian (Grenvillian) orogen of SW ScandinaviaBolle, Olivier ; Diot, Hervé; Trindade, Ricardo I.F.in Precambrian Research (2003), 121(3-4), 221-249Detailed reference viewed: 20 (0 ULiège) Identification of heterologous multicopy suppressors of the yeast msb3msb4 double mutationDelroisse, Jean-Marc; Breban, Martine; Burny, Arsène et alin Yeast (2003), 20(S291), Detailed reference viewed: 8 (0 ULiège) De Cheddar- en Creswell-spitsen van Zeijen (Dr.): ‘projectielen’ of ‘messen’?Rots, Veerle ; Stapert, Dick; Johanssen, Lykkein Paleo-Aktueel (2003), 13Detailed reference viewed: 31 (1 ULiège) Development Of Real-Time Pcr For The Rapid Detection Of Episomal Banana Streak Virus (Bsv)Delanoy, Martine; Salmon, Marc ; Kummert, Jean et alin Plant Disease (2003), 87(1), 33-38Detailed reference viewed: 35 (5 ULiège) A new method for reconstruction of the vertical electron density distribution in the upper ionosphere and plasmasphereStankov, Stanimir; Jakowski, Norbert; Muhtarov, Plamen et alin Journal of Geophysical Research. Space Physics (2003), 108(A51164), 1164Detailed reference viewed: 30 (4 ULiège) La figure de la Vierge Marie dans l’histoire des femmes et du féminismeDelfosse, Annick in Hieros : Bulletin Annuel de la Société Belgo-luxembourgeoise d'Histoire des Religions (2003), 8The A. offers to study the place of the Marian figure in the women story. She proves to show various points of view: the masculine cleric authorities’ use of the Virgin as an identification norm imposed ... [more ▼]The A. offers to study the place of the Marian figure in the women story. She proves to show various points of view: the masculine cleric authorities’ use of the Virgin as an identification norm imposed to the women as well as the claim of these latter to define the Virgin also as an emancipation tool. [less ▲]Detailed reference viewed: 358 (20 ULiège) Etude rétrospective de quarante et un cas d’insuffisance mitrale chez le cheval (1995-2001).Maurin, Emmanuel; Amory, Hélène ; Sandersen, Charlotte in Pratique Vétérinaire Equine (2003), 35Une étude rétrospective portant sur quarante et un chevaux qui présentent une insuffisance cardiaque mitrale a été réalisée afin de mieux décrire cette affection et de préciser les répercussions médicales ... [more ▼]Une étude rétrospective portant sur quarante et un chevaux qui présentent une insuffisance cardiaque mitrale a été réalisée afin de mieux décrire cette affection et de préciser les répercussions médicales et sportives liées à cette maladie. L'insuffisance mitrale est diagnostiquée grâce à des examens cliniques et échographiques, puis un questionnaire (évolution clinique et sportive) est adressé aux propriétaires des animaux. L’analyse de ces dossiers permet en particulier d’évaluer, d'une part, l’existence d’une association entre les signes d’insuffisance cardiaque congestive et certaines lésions cardio-vasculaires (lésions valvulaires, dilatation de l’atrium gauche, etc.) ou d'autres symptômes (fibrillation auriculaire, etc.), d'autre part, d’apprécier la corrélation éventuelle entre ces différents symptômes ou lésions et la survie des chevaux affectés. Les résultats ainsi que les biais possibles de cette étude sont ensuite discutés. [less ▲]Detailed reference viewed: 27 (7 ULiège) Synopsis des dermatomycoses invasives chez l'immunodéprimé.Quatresooz, Pascale ; Arrese Estrada, Jorge ; Pierard, Gérald in Revue Médicale de Liège (2003), 58(11), 690-4The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These ... [more ▼]The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These mycoses may become invasive and a fatal issue is possible. In other circumstances, the inoculation site is pulmonary or digestive, and the cutaneous lesions represent secondary localizations. [less ▲]Detailed reference viewed: 167 (4 ULiège) Le développement de la filière "Poulet d'Ardenne" en Région WallonneLeroy, Pascal in Troupeaux et cultures des tropiques (2003), 2Detailed reference viewed: 9 (1 ULiège) Interlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty.Dehouck, P.; Vander Heyden, Y.; Smeyers-Verbeke, J. et alin Journal of Chromatography. A (2003), 1010(1), 63-74Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been ... [more ▼]Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in one laboratory, the method was now validated in an interlaboratory study. Validation studies are commonly used to test the fitness of the analytical method prior to its use for routine quality testing. The data derived in the interlaboratory study can be used to make an uncertainty statement as well. The relationship between validation and uncertainty statement is not clear for many analysts and there is a need to show how the existing data, derived during validation, can be used in practice. Eight laboratories participated in this interlaboratory study. The set-up allowed the determination of the repeatability variance, s(2)r and the between-laboratory variance, s(2)L. Combination of s(2)r and s(2)L results in the reproducibility variance s(2)R. It has been shown how these data can be used in future by a single laboratory that wants to make an uncertainty statement concerning the same analysis. [less ▲]Detailed reference viewed: 48 (4 ULiège) Effect of somatic growth, strain and sex on double-chamber plethymosgraphic respiratory function values in healthy miceFlandre, Th.; Leroy, Pascal ; Desmecht, Daniel in Journal of Applied Physiology (2003), 94(3), 1129-1136Detailed reference viewed: 7 (0 ULiège) Leçons de l’éphémère. La Cour d’arbitrage et le "Renouveau’ électoral" – La Cour d’arbitrage et la suspensionRosoux, Géraldine in Revue Belge de Droit Constitutionnel (2003)The articles analyzes the electoral reform of 2003 and points out the competence of the Belgian constitutional Court to suspend legislative norms.Detailed reference viewed: 74 (6 ULiège) Estrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseasesRakic, Jean-Marie ; Lambert, Vincent ; Deprez, Manuel et alin Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]Detailed reference viewed: 96 (22 ULiège) Adaptive mesh generation for mould filling problems in resin transfer mouldingBéchet, Eric ; Ruiz, E.; Trochu, François et alin Composites : Part A, Applied Science & Manufacturing (2003), 34(9), 813-834In injection moulding processes such as Resin Transfer Moulding (RTM) for example, numerical simulations are usually performed on a fixed mesh, on which the numerical algorithm predict the displacement of ... [more ▼]In injection moulding processes such as Resin Transfer Moulding (RTM) for example, numerical simulations are usually performed on a fixed mesh, on which the numerical algorithm predict the displacement of the flow front. Error estimations can be used in the numerical algorithm to optimise the mesh for the finite element analysis. The mesh can be also adapted during mould filling to follow the shape of the moving boundary. However, in order to minimize computer time, it is preferable to optimise the mesh before carrying out the filling calculation. In this paper, these ideas are adapted to 3D shells, which represent the most common type of composite parts manufactured by RTM. An error estimator generally used in planar or solid geometries is extended for curved 3D surfaces in the specific case of RTM calculations. The extension consists of a projection of the solution field in the tangent plane to avoid problems related to the curvature of the part. Some other issues specific to shell geometries are pointed out and the results of a filling simulation made on a real part are presented. Non-isothermal filling simulations are also carried out in a rectangular mould to illustrate the stability conditions that arise from the convective heat transfer problem. Finally, an analytical study of radial injections is carried out to illustrate issues related to four types of different mesh refinement procedures: (1) a constant time step, (2) constant radial density (to allow a regular progression of the flow front at each time step), (3) a constant Courant number (to ensure stable thermal simulations); and (4) finally, a constant interpolation error. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]Detailed reference viewed: 71 (4 ULiège) A review of the major causes of digestive disorders in the European rabbitMarlier, Didier ; Dewrée, Roxane; Delleur, Valéry et alin Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 385-392Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state ... [more ▼]Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state of knowledge on two diseases of unknown origin, the so called Rabbit Epizootic Enteropathy and Mucoid Enteropathy is also presented. [less ▲]Detailed reference viewed: 122 (11 ULiège) Liège-Paris 1848 : Littérature, féminisme et RévolutionDroixhe, Daniel in Bulletin de l'Académie Royale de Langue et de Littérature Françaises (2003), LXXXI(1-2), 41-49Detailed reference viewed: 84 (5 ULiège) Training and testing in open versus closed kinetic chainMayer, F; Schlumberger, A; van Cingel, R et alin Isokinetics & Exercise Science (2003), 11Detailed reference viewed: 27 (1 ULiège) Magnetic and mossbauer spectral study of ErFe11Ti and ErFe11TiHPiquer, C.; Hermann, Raphaël ; Grandjean, Fernande et alin Journal of Applied Physics (2003), 93(6), 3414-3421X-ray diffraction, isothermal magnetization at 5 and 300 K, ac magnetic susceptibility measurements between 5 and 200 K, and iron-57 Mossbauer spectral measurements between 4.2 and 295 K have been carried ... [more ▼]X-ray diffraction, isothermal magnetization at 5 and 300 K, ac magnetic susceptibility measurements between 5 and 200 K, and iron-57 Mossbauer spectral measurements between 4.2 and 295 K have been carried out on ErFe11Ti and ErFe11TiH. Hydrogen uptake has been measured by gravimetric analysis and the insertion of hydrogen into ErFe11Ti increases its magnetization, magnetic hyperfine fields, and isomer shifts as a result of the associated lattice expansion. Peaks and steplike changes in both the real and imaginary components of the ac magnetic susceptibility are observed at similar to50 and 40 K for ErFe11Ti and ErFe11TiH, respectively, and are assigned to spin-reorientation transitions resulting from the temperature dependence of the sixth-order Stevens crystal-field term of erbium. The Mossbauer spectra have been analyzed with a model which considers both these spin reorientations and the distribution of titanium atoms in the near-neighbor environment of the three crystallographically distinct iron sites. The assignment and the temperature dependencies of the hyperfine fields and isomer shifts are in complete agreement with the Wigner-Seitz cell analysis of the three iron sites in ErFe11Ti and ErFe11TiH. The changes in the hyperfine field and isomer shift with the number of titanium near neighbors of the three iron sites are in agreement with the values observed for related titanium-iron intermetallic compounds. (C) 2003 American Institute of Physics. [less ▲]Detailed reference viewed: 6 (0 ULiège) The Nucleon-Nucleon Problem in Quark ModelsStancu, Floarea in Few-Body Systems (2003), 14In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from ... [more ▼]In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from the Goldstone-boson exchange model by applying the resonating group method. The second part deals with the construction of local shallow and deep equivalent potentials based on a Superymmetric Quantum Mechanics approach. [less ▲]Detailed reference viewed: 16 (2 ULiège) Preschoolers' use of form class cues to learn descriptive proper namesHall, D. G.; Waxman, S. R.; Brédart, Serge et alin Child Development (2003), 74(5), 1547-1560This study examined 3- and 4-year-old preschoolers' ability to learn proper names containing familiar descriptions. Children saw a novel creature with a familiar property (it was red) and heard either an ... [more ▼]This study examined 3- and 4-year-old preschoolers' ability to learn proper names containing familiar descriptions. Children saw a novel creature with a familiar property (it was red) and heard either an adjective ("This is a red one") or a descriptive proper name ("This is Mr. Red"). The creature was then transformed, losing the property (e.g., it became green). Children had to extend the word to either the transformed original creature or a new creature bearing the original property (another red creature). Children, especially 4-year-olds, extended the adjective to the new creature but were significantly more likely to extend the proper name to the original creature. Lexical form class cues provided potent information about word meaning, directing preschoolers to reinterpret familiar descriptive terms (adjectives) as homophonic terms designating unique individuals (proper names). [less ▲]Detailed reference viewed: 58 (10 ULiège) Mons/Maisières : les occupations paléolithiques de "l'Atelier de Taille de la Berge Nord-Est" à Maisières-CanalMiller, Rebecca ; Guillaume, Alain; Otte, Marcel in Chronique de l'Archéologie Wallonne (2003), 11Detailed reference viewed: 16 (0 ULiège) Optimisation de la transformation génétique de la pomme de terre par Agrobacterium tumefaciens. Utilisation de la résistance à l'hygromycine comme marqueur sélectif.M'Hamdi, M.; Rouvière, C.; Rojas-Beltran J et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7Detailed reference viewed: 33 (0 ULiège) IntroductionJacquemain, Marc ; Verjans, Pierre in Fédéralisme - Régionalisme (2003), 2002-2003(n° spécial « Mobilité et identités dans l’Eurégio Meuse-Rhin »), 3-11Detailed reference viewed: 25 (8 ULiège) The fate of the adjacent motion segments after lumbar fusion.Gillet, Philippe in Journal of Spinal Disorders & Techniques (2003), 16(4), 338-45Lumbar spine fusion is a commonly performed procedure in various pathologic conditions of the spine. Its role remains debated, and moreover, delayed complications may occur, among which is transitional ... [more ▼]Lumbar spine fusion is a commonly performed procedure in various pathologic conditions of the spine. Its role remains debated, and moreover, delayed complications may occur, among which is transitional segment alteration leading to recurrence of back pain, gross instability, and neurologic symptoms. Little is known about the long-term prevalence of this complication because of a lack of specific studies. We analyzed the fate of the transitional segments in a homogeneous group of patients operated on during a 14-year period for degenerative conditions of the lumbar spine resistant to conservative treatment. Follow-up ranged from 2 to 15 years. Seventy-five percent of our study group had a minimal 5-year follow-up. In this subgroup, 41% of the patients developed transitional segment alterations, and 20% needed a secondary operation for extension of the fusion. Potential risk factors such as postoperative delay, length of fusion, and spine imbalance were recognized. The frequency of delayed alterations of the adjacent segment and the severity of symptoms related to this complication in this study raise questions about the justification of fusion procedures in degenerative conditions of the spine without threatening instability. Data from the literature confirm the severity of the problem, but many uncertainties remain because of the lack of homogeneous and complete data on both the normal evolution of motion segments of the lumbar spine with age and the fate of the same segments when transformed in transitional segments. Future prospective studies on the subject are needed and must deal with homogeneous groups of patients. More reconstructive surgical procedures need to be developed to lessen the need for fusion procedures. [less ▲]Detailed reference viewed: 43 (5 ULiège) Design and simulation of a solar dryer for agriculture productsBennamoun, Lyes ; Belhamri, Azeddinein Journal of Food Engineering (2003), 59(2-3), Detailed reference viewed: 56 (6 ULiège) Prevention de la fracture de la hanche chez le sujet age: ou en sommes-nous en 2003?Reginster, Jean-Yves ; Lecart, Marie-Paule ; Sarlet, Nathalie et alin Revue Médicale de Liège (2003), 58(4), 183-90Osteoporosis in very elderly subjects is now considered, in most developed and several developing countries as a major social, clinical and financial burden. While many compounds have been investigated in ... [more ▼]Osteoporosis in very elderly subjects is now considered, in most developed and several developing countries as a major social, clinical and financial burden. While many compounds have been investigated in the prevention or treatment of spinal fractures, few of them have unequivocally demonstrated their ability to reduce the risk of non vertebral and more specifically hip fractures in the very elderly. This situation may seem highly paradoxical since hip fractures are unanimously considered to be the most dramatic and disabling consequence of osteoporosis. The present article reviews the current evidence available to justify anti-osteoporotic medications to be recommended to very elderly subjects, in the perspective of reducing their risk of appendicular fractures. [less ▲]Detailed reference viewed: 49 (5 ULiège) Observations sous Anvers, 12 septembre 2002Boularbah, Hakim ; Marquette, V.in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (2003)Detailed reference viewed: 16 (0 ULiège) Cacophonie jurisprudentielle autour de la notion d’impôtRosoux, Géraldine in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)The article analyzes a decision of the Belgian judicial Supreme Court concerning the concept of "tax", and emphasizes the conflict between this decision and the case-law of the Belgian constitutional CourtDetailed reference viewed: 93 (15 ULiège) Development and validation of a specific radioimmunoassay for equine osteocalcinCarstanjen, Bianca; Sulon, Joseph ; Banga-Mboko, H. et alin Domestic Animal Endocrinology (2003), 24(1), 31-41This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard ... [more ▼]This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard, tracer, and immunogen for antibody formation in rabbits. The assay allowed to measure equine serum OC levels with a sensitivity of 0.2 ng/mL. Immunoreactive serum OC values of clinically normal, different-aged horses ranged from 3.68 to 127.31 ng/mL. Intra- and inter-assay coefficients of variation (CV) were 6.2 and 8.2%, respectively. Serial equine scrum sample dilutions were linear. The recovery of equine OC from equine serum samples ranged from 93.88 to 107.9%. There was a tight correlation between OC values measured with the equine- specific OC RIA and two commercially available bovine-specific OC RIA kits. However, highest serum OC values were obtained with the equine-specific OC RIA. In conclusion, our equine-specific OC RIA is sensitive, linear, accurate, precise, and reproducible. The assay allowed to quantify OC in equine serum samples and might, therefore, be used to monitor equine osteoblast activity associated with bone diseases, exercise, therapy forms or diet. [less ▲]Detailed reference viewed: 40 (1 ULiège) Expression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogeneBizimungu, Christelle; Burny, Arsène; De Nève, Nancy et alin Archives Internationales de Physiologie et de Biochimie (2003), 184Detailed reference viewed: 5 (0 ULiège) Korean experience with the OSTA risk index for osteoporosis: a validation study.Park, H. M.; Sedrine, W Ben; Reginster, Jean-Yves et alin Journal of Clinical Densitometry : The Official Journal of the International Society for Clinical Densitometry (2003), 6(3), 247-50The Osteoporosis Self-assessment Tool for Asians (OSTA) was developed to help physicians focus their efforts on patients at increased risk, and encourage appropriate use of bone mineral density (BMD ... [more ▼]The Osteoporosis Self-assessment Tool for Asians (OSTA) was developed to help physicians focus their efforts on patients at increased risk, and encourage appropriate use of bone mineral density (BMD) measurements. Previously, OSTA performed well in a sample of women from eight countries in Asia, and in a validation group of Japanese women. In this study, we evaluate the performance of OSTA using a sample of 1101 postmenopausal women from a clinic in Korea who had femoral neck BMD measurements by dual-energy X-ray absorptiometry (DXA). The OSTA had a high sensitivity (87%), and good specificity (67%) for identifying osteoporosis (BMD T-scores -1) to 64% among those classified as high risk (OSTA < -4); these results were almost identical to those reported earlier for a sample of women from eight Asian countries. We conclude that the OSTA risk tool performed well in this sample of postmenopausal Korean women, similar to previous results in other Asian women. The OSTA tool is free and very easy to use; risk can be tabulated by age and weight, so that calculations are not necessary. Using OSTA could encourage patients and clinicians to actively assess osteoporosis, and measure BMD when appropriate, before fractures occur. [less ▲]Detailed reference viewed: 14 (2 ULiège) Horizontal And Vertical Co2 Advection In A Sloping ForestAubinet, Marc ; Heinesch, Bernard ; Yernaux, Michel in Boundary-Layer Meteorology (2003), 108(3), Detailed reference viewed: 25 (3 ULiège) The extraforaminal juxtafacet cyst as a rare cause of L5 radiculopathy: a case report.Salmon, Bernard L; Deprez, Manuel ; Stevenaert, Achille et alin Spine (2003), 28(19), 405-7STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal ... [more ▼]STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal juxtafacet cysts develop most frequently at the dorsal aspect of the zygapophysial joint, sometimes in the posterolateral area of the canal. In one case, they have been described in the foraminal and extraforaminal region. METHODS: Description of the case report. RESULT: The authors report one case of a strictly extraforaminal juxtafacet cyst responsible for L5 sciatica. CONCLUSIONS: Juxtafacet cysts of the spine represent an infrequent cause of sciatica, usually when they grow in the canal, or more exceptionally when they occupy the foraminal or extraforaminal areas. [less ▲]Detailed reference viewed: 28 (0 ULiège) La résolution de problèmes : un processus complexe de 'modélisation mathématique'Fagnant, Annick ; Demonty, Isabelle ; Lejong, Michèle in Informations pédagogiques (2003), 54Detailed reference viewed: 176 (21 ULiège) Large phosphorus hyperfine coupling as a sensitive tool for studying molecular dynamics : ESR and Molecular Mechanics studies of ring interconversion in cis-2,5-diphosphoryl-2,5-dimethyl-pyrrolidinoxyl radicalRockenbauer, Antal; Gaudel-Siri, Anouk; Siri, Didier et alin Journal of Physical Chemistry A (2003), 107(19), 3851-3857ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was ... [more ▼]ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was observed for t-1; however, for c-1, the inner lines of the 1:2:1 triplet showed a dramatic broadening characteristic of chemical exchange between two equivalent conformations. Owing to the large difference in the hyperfine splitting constants (hfsc) of the exchanging phosphorus (¢aP 21 G), the coalescence temperature was unusually high (193 K, in n-pentane), and the potential barrier for ring interconversion (10.5 kJ mol-1) was easily obtained from the temperature dependence of the exchange rate. This value was in very good agreement with the value obtained for an empirical pseudorotational potential (11 kJ mol-1) that was adjusted to fit the temperature dependence of the phosphorus hfsc. For c-1, molecular mechanics calculations gave similar characteristics for the pseudorotational potential and indicated the existence of two identical minima with distorted geometries lying between 3T4 and 3E or 4T3 and E3. For t-1, only the 3T4 conformer was found to be significantly populated. Frozen solution spectra showed that the phosphorus hfsc anisotropy is higher when the C-P bond is pseudoaxial; this result can be explained by a geometry-dependent delocalization of the unpaired electron into the phosphorus 3p orbitals. [less ▲]Detailed reference viewed: 20 (1 ULiège) Case 61: ileocecal sarcoidosis.NCHIMI LONGANG, Alain ; Francotte, Nadine; Rausin, Leon et alin Radiology (2003), 228(2), 452-5Detailed reference viewed: 16 (2 ULiège) Enquête sur les "contes" de Voltaire (II)Tilkin, Françoise in Cahiers Voltaire : Revue Annuelle de la Société Voltaire (2003), 2Detailed reference viewed: 18 (1 ULiège) Perfluorocarbons and Haemoglobin Solutions: Will They Ever Reach Clinical Practice?Lamy, Maurice ; Deby-Dupont, G.in Acta Anaesthesiologica Belgica (2003), 54(4), 299-300Detailed reference viewed: 38 (4 ULiège) Altered neuronal excitability in cerebellar granule cells of mice lacking calretininGall, D.; Roussel, C.; Susa, I. et alin Journal of Neuroscience (2003), 23(28), 9320-9327Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar ... [more ▼]Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar granule cells, which provide the major excitatory input to Purkinje cells through parallel fibers. Calretinin-deficient mice exhibit dramatic alterations in motor coordination and Purkinje cell firing recorded in vivo through unknown mechanisms. In the present study, we used patch-clamp recording techniques in acute slice preparation to investigate the effect of a null mutation of the calretinin gene on the intrinsic electroresponsiveness of cerebellar granule cells at a mature developmental stage. Calretinin-deficient granule cells exhibit faster action potentials and generate repetitive spike discharge showing an enhanced frequency increase with injected currents. These alterations disappear when 0.15 mm of the exogenous fast-calcium buffer BAPTA is infused in the cytosol to restore the calcium-buffering capacity. A proposed mathematical model demonstrates that the observed alterations of granule cell excitability can be explained by a decreased cytosolic calcium-buffering capacity resulting from the absence of calretinin. This result suggests that calcium-binding proteins modulate intrinsic neuronal excitability and may therefore play a role in information processing in the CNS [less ▲]Detailed reference viewed: 26 (1 ULiège) Shellfish, a dangerous food?China, Bernard; de Schaetzen, Marie-Athénaïs ; Daube, Georges in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 413-422Sea products are consumed worldwide. Seafood, especially shellfish, is consumed crude or not well cooked therefore they are risky for the development of foodborne diseases. Moreover, these animals filter ... [more ▼]Sea products are consumed worldwide. Seafood, especially shellfish, is consumed crude or not well cooked therefore they are risky for the development of foodborne diseases. Moreover, these animals filter water and concentrate the microorganisms and the toxins. Risks are multiple : bacteria (Clostridium, Vibrio), viruses (norovirus, hepatitis A) and the biotoxins (paralytic, neurotoxic, diarrhoeic and amnesic) produced by phytoplankton. The European regulation 91/492/EC indicates the microbiological and toxicological criteria for the sale of the shellfish. Nevertheless, in the absence of good diagnosis methods, the viruses were omitted in this regulation. But it is a major cause of toxi-infection due to shellfish consumption. The large number of outbreaks worldwide due to the ingestion of seafood indicates that these ones must be carefully controlled. Therefore, we need powerful diagnosis tools. The aim of this review is to describe the major biological risks (bacteria, viruses, biotoxins) for the human health linked to the consumption of sea food. [less ▲]Detailed reference viewed: 183 (9 ULiège) Analyses technologiques d’un atelier de taille aurignacien à Maisières-Canal (Province du Hainaut, Belgique)Miller, Rebecca ; Flas, Damien ; Guillaume, Alain et alin Notae Praehistoricae (2003), 23Detailed reference viewed: 12 (1 ULiège) Specific G2 arrest of caprine cells infected with a caprine arthritis encephalitis virus expressing vpr and vpx genes from simian immunodeficiency virusBouzar, Amel ; Guigen, F.; Morin, T. et alin Virology (2003)Detailed reference viewed: 13 (0 ULiège) Estimation of habitat quality based on plant community, and effects of isolation in a network of butterfly habitat patchesSawchik, J.; Dufrêne, Marc ; Lebrun, Philippein Acta Oecologica (2003), 24(1), 25-33Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ... [more ▼]Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ecological network for five butterfly species (Brenthis ino, Clossiana selene, Lycaena helle, Lycaena hippothoe, Proclossiana eunomia) inhabiting wet meadows. Abundance predictions were performed on the basis of botanical relevés with a multiple-species approach combining canonical correspondence analysis and multiple regression. Models are defined on a reference site set and are evaluated on a test site set. All the fitted models predicted the abundance of the butterfly species considerably well (from 61 to 86% of the variation). We evaluated the potential consequences of isolation on local populations, by comparing predicted and observed abundance. It was expected that greater differences would be observed when sites were more isolated. On the test set, differences between predicted and observed abundance were largely correlated to site isolation for L. helle and P. eunomia. The most isolated sites had greater chances to be empty, even if they had high-quality habitat. Reciprocally, when the sites were less isolated, the abundance observed was always greater than predicted, seeming to confirm the role of rescue effects. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. [less ▲]Detailed reference viewed: 37 (4 ULiège) Effet de l'intensité d'un stimulus gravitationnel induit artificiellement sur la croissance et la formation du bois de tension dans de jeunes pousses de peuplier (Populus euramericana cv. Ghoy).Jourez, Benoit; Vaianopoulos, Céline; Hebert, Jacques in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60(8), 789-802The formation of tension wood tissue is artificially induced by means of a gravitational stimulus obtained by inclining young shoots of poplar at different intensities, from 0 to 30°, during a growing ... [more ▼]The formation of tension wood tissue is artificially induced by means of a gravitational stimulus obtained by inclining young shoots of poplar at different intensities, from 0 to 30°, during a growing season. At the end of the experiment, it appears that shoot elongation as well as the angle of tension wood arc are not affected by the stimulus intensity. In contrast, the upright reorientation of the axis, the amount of gelatinous fibres, the secondary growth over bark, the cross-section area of the stem and of the secondary xylem, the different rays, the diameter under bark and the pith eccentricity, react quantitatively to the lean intensity. The amount of tension wood is correlated with the upright reorientation, the secondary growth over bark and the radial growth under bark. Tension wood formation and eccentricity react to the gravitational stimulus but they are not causally linked. Finally, it exists a natural equilibrium position, different from the vertical, to which moved shoots try to return via the formation of a tension wood tissue. [less ▲]Detailed reference viewed: 68 (16 ULiège) Writing and the Other Arts in Wilson Harris's FictionMaes-Jelinek, Hena in Commonwealth : Essays and Studies (2003), SP 5Detailed reference viewed: 16 (1 ULiège) Radiothérapie métabolique des douleurs osseuses d'origine métastatique : nouveaux traitements, nouvelles pratiquesHustinx, Roland ; Paulus, Patrickin Annales de l'Association Belge de Radioprotection = Annalen van de Belgische Vereniging voor Stralingsbescherming (2003), 28Le traitement palliatif des douleurs osseuses liées à la dissémination métastatique s'est récemment enrichi d'une molécule, le 153Sm-EDTMP (Quadramet). Le traitement classique faisait appel au Strontium ... [more ▼]Le traitement palliatif des douleurs osseuses liées à la dissémination métastatique s'est récemment enrichi d'une molécule, le 153Sm-EDTMP (Quadramet). Le traitement classique faisait appel au Strontium-89 (Métastron). Alors que ce dernier est un émetteur bêta pur, de longue demi-vie (50,5 jours), le 153Sm émet également un rayonnement gamma de 103 keV, et sa période physique est de 1,95 jours. Dans cet exposé nous envisagerons, du point de vue de la radioprotectio, les propriétés pharmacocinétiques du radiopharmaceutique et les caractéristiques physiques du 153Sm. Nous relaterons également l'expérience acquise dans notre centre avec le 186Re-HEDP. [less ▲]Detailed reference viewed: 59 (2 ULiège) Caractérisation génotypique de souches invasives aviaires d'Escherichia coli isolées en BelgiqueStordeur, P.; Beaupain, N.; Mainil, Jacques in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 275-280Detailed reference viewed: 6 (0 ULiège) Identification of heterologous multicopy suppressors of the yeast msb3msb4 double mutationDelroisse, Jean-Marc; Breban, Martine; Burny, Arsène et alin Archives Internationales de Physiologie et de Biochimie (2003), 184Detailed reference viewed: 9 (0 ULiège) La Convention de BruxellesBoularbah, Hakim ; Nuyts, Arnaud; Watte, N.in Journal des Tribunaux Droit Européen (2003)Detailed reference viewed: 19 (2 ULiège) Développement de modèles prédictifs des proportions de duramen et d'écorce des espèces de mélèze cultivées en zones de basse altitude en Europe de l'Ouest (Larix kaempferi (Lambert) Carr., Larix decidua Miller et Larix eurolepis Henry).Pauwels, D.; Lejeune, Philippe ; Paques, L. E. et alin Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60(3), 227-235Predictive models for heartwood and bark proportions have been developed for Japanese larch (Larix kaempferi (Lambert) Carr.) planted in South of Belgium. These models have been tested to evaluate the way ... [more ▼]Predictive models for heartwood and bark proportions have been developed for Japanese larch (Larix kaempferi (Lambert) Carr.) planted in South of Belgium. These models have been tested to evaluate the way of applying them to European larch (Larix decidua Miller) and hybrid larch (Larix eurolepis Henry) growing in west-European lowlands. For the heartwood proportion, independent variables selected are stand age and dbh. The model set up for Japanese larch has a R-square of 0.859. In average, European larch has lower heartwood proportion. With reference to bark proportion, selected independent variable is dbh. Residual variability is far more important for bark models (R-square of 0.456). European larch has, in average, higher bark proportion whereas hybrid larch has lower. An example of the application of these models in connection with a growth model is presented. It consists in an evaluation of the impact of dynamic silviculture on heartwood and bark proportion. [less ▲]Detailed reference viewed: 80 (11 ULiège) Mycoplasma bovis : synthèse des connaissances actuellesThomas, Anne; Mainil, Jacques ; Linden, Annick in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 23-39Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia ... [more ▼]Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia, arthritis and mastitis, and is thus associated with strong economic losses. Several studies have shown the frequency of M. bovis in Europe and the spread of antibiotic-resistant strains. Considering the absence of vaccine in Europe, it is essential to understand this bacteria in order to control the infection in cattle. In this context, this paper aims at summarizing the current knowledge about M. bovis. [less ▲]Detailed reference viewed: 168 (12 ULiège) Event-related potentials to emotional and neutral stimuli in alcoholism.Hansenne, Michel ; Olin, Cecile; Pinto, Emmanuel et alin Neuropsychobiology (2003), 48(2), 77-81Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated ... [more ▼]Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated. Subjects were 10 alcoholic inpatients (3 female) and 10 age- and sex-matched controls. Eight alcohol-related and 8 neutral words served as stimuli in a visual oddball paradigm. Acohol-related words were targets (48 stimuli, 33%) and neutral words were standard stimuli (96 stimuli, 66%). Results showed that P300 amplitude for targets did not differ significantly between the two groups. However, P300 latency for targets as well as reaction time were significantly shorter in male alcoholic patients. In contrast, P300 latency was increased in female alcoholic patients but reaction time did not differ. These results suggest that male alcoholics process information linked to alcohol cues more rapidly than neutral cues, probably because a specific semantic network is activated in these patients. The decreased reaction time confirms the impulsive behavior frequently found in male alcoholism, as it has been described in type II alcoholism. Besides, the results imply that information processing was delayed in female alcoholic patients. Therefore this study demonstrates a gender-dependent impact of alcohol-related stimuli on information processing. [less ▲]Detailed reference viewed: 62 (8 ULiège) L'image du mois. Sous le pont myocardique coule la coronaire.ROUSSEAU, Anne-Françoise ; MIEVIS, Ericin Revue Médicale de Liège (2003), 58(10), 601-604Detailed reference viewed: 21 (3 ULiège) A model of the seasonal dynamics of biomass and production of the seagrass Posidonia oceanica in the Bay of Calvi (Northwestern Mediterranean)Elkalay, Khalid; Frangoulis, Constantin; Skliris, Nikolaos et alin Ecological Modelling (2003), 167(1-2), 1-18Modelling of seagrasses can be an effective tool to assess factors regulating their growth. Growth and production model of Posidonia oceanica, the dominant submerged aquatic macrophyte occurring in the ... [more ▼]Modelling of seagrasses can be an effective tool to assess factors regulating their growth. Growth and production model of Posidonia oceanica, the dominant submerged aquatic macrophyte occurring in the Bay of Calvi (Corsica, Ligurian Sea, Northwestern (NW) Mediterranean) was developed. The state variables are the above- and below-ground biomass of P oceanica, the epiphyte biomass, and the internal nitrogen concentration of the whole plant. Light intensity and water temperature are the forcing variables. The model reproduces successfully seasonal growth and production for each variable at various depths (10, 20 and 30 m). The model can simulate also a number of consecutive years. Sensitivity analysis of model's parameters showed that the maximum nitrogen quota n(max) rate is the most sensitive parameter in this model. The results simulations imply that light intensity is one of the most important abiotic factors, the diminution of which can cause an important reduction in seagrass density. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]Detailed reference viewed: 114 (18 ULiège) Facteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : I) les adhésines et facteurs de colonisationMainil, Jacques in Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 105-126Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, enterohaemmorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections): If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains: adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This first manuscript presents the current knowledge on the receptors, roles in pathogenesis, structures, genetic determinism and identification methods of fimbrial adhesins of P (Pap, Prs), S (Sfa, F1C, Sfr) and F17 (Vir, Att25, FY, 20K, G, Att111) families and of afimbrial adhesins of Afa family (Afa, Nfa, F1845, Bma, Dr...). [less ▲]Detailed reference viewed: 22 (1 ULiège) Energy conservation and dissipation in mitochondria isolated from developing tomato fruit of ethylene-defective mutants failing normal ripening: the effect of ethephon, a chemical precursor of ethylene.Navet, R.; Jarmuszkiewicz, W.; Almeida, A. et alin Journal of Bioenergetics & Biomembranes (2003), 35(2), 157-168Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two ... [more ▼]Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two energy-dissipating systems exhibit large variations during tomato fruit development and ripening on the vine. It has been suggested that AOX and UCP could be responsible for the respiration increase at the end of ripening and that the cytochrome pathway could be implicated in the climacteric respiratory burst before the onset of ripening. In this study, the use of tomato mutants that fail normal ripening because of deficiencies in ethylene perception or production as well as the treatment of one selected mutant with a chemical precursor of ethylene have revealed that the bioenergetics of tomato fruit development and ripening is under the control of this plant hormone. Indeed, the evolution pattern of bioenergetic features changes with the type of mutation and with the introduction of ethylene into an ethylene-synthesis-deficient tomato fruit mutant during its induced ripening. [less ▲]Detailed reference viewed: 28 (4 ULiège) Solution structural study of BlaI: implications for the repression of genes involved in beta-lactam antibiotic resistance.Melckebeke, Helene Van; Vreuls, Christelle ; Gans, Pierre et alin Journal of Molecular Biology (2003), 333(4), 711-20beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam antibiotics, which are otherwise highly clinically effective. Two repressors (BlaI and MecI) regulate ... [more ▼]beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam antibiotics, which are otherwise highly clinically effective. Two repressors (BlaI and MecI) regulate expression of these inducible proteins. Here, we present the first solution structure of the 82 amino acid residue DNA-binding domain of Bacillus licheniformis BlaI which is very similar in primary sequence to the medically significant Staphyloccocal BlaI and MecI proteins. This structure is composed of a compact core of three alpha-helices and a three-stranded beta-sheet typical of the winged helix protein (WHP) family. The protein/DNA complex was studied by NMR chemical shift comparison between the free and complexed forms of BlaI. Residues involved in DNA interaction were identified and a WHP canonical model of interaction with the operators is proposed. In this model, specific contacts occur between the base-pairs of the TACA motif and conserved amino acid residues of the repressor helix H3. These results help toward understanding the repression and induction mechanism of the genes coding for beta-lactamase and PBP2'. [less ▲]Detailed reference viewed: 51 (10 ULiège) Problématique des inondations et des aménagements : exemple des complémentarités de l'apport des Ingénieurs du Génie Civil et des BioIngénieurs du Génie RuralDautrebande, S.; Pirotton, Michel in Journal des Ingénieurs (Le) (2003), 88Detailed reference viewed: 84 (10 ULiège) Accuracy of the continuous glucose monitoring system in inpatient and outpatient conditionsDjakouré-Platonoff, C.; RADERMECKER, Régis ; Reach, G. et alin Diabètes & Métabolism (2003), 29Detailed reference viewed: 33 (5 ULiège) Note sur les hétéroptères des cultures maraîchères de plein champColignon, P.; Francis, Frédéric ; Haubruge, Eric in Notes Fauniques de Gembloux (2003), 51Detailed reference viewed: 47 (3 ULiège) Chronique de législation - Droit privé belge (1er janvier 2003 - 30 juin 2003) : IX. Droit judiciaire privé et arbitrageBoularbah, Hakim in Journal des Tribunaux (2003)Detailed reference viewed: 5 (2 ULiège) Effets de la réduction de doses de formulations d’insecticides et de fongicides sur l’auxiliaire non cible Episyrphus balteatus DegeerColignon, P.; Haubruge, Eric ; Gaspar, C. et alin Phytoprotection (2003), 84Detailed reference viewed: 18 (3 ULiège) Contre l'ankylose de l'imaginationFrankignoulle, Pierre ; Bianchi, Michaelin A+ : Architecture in Belgium (2003), 181Detailed reference viewed: 31 (5 ULiège) Modèle de croissance pour les plantations de mélèzes.Pauwels, D.; Lejeune, Philippe ; Rondeux, Jacques in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(2), 87-97A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches ... [more ▼]A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches (Japanese, European and Hybrid larches) in 99 stands. It enables to predict tree circumference increment from circumference, dominant height, basal area, age and site index of stands. Estimating increments of 1283 larches in 48 stands has been used to validate the model that gives unbiased estimates of the increments (mean error = -0.002 cm with standard deviation of 0.60 cm). The mean absolute error of estimates is 0.46 cm.year-1. The model has also been tested to predict the increment of larches in French experimental plots having very different silvicultural treatments. The residues of these estimations depend on the stand basal area: the lesser the stand basal area, the higher the residues of the estimation. A correction factor, linked to basal area through a Bailey and Clutter curve, has been introduced to extend the validity of the model to stands with a basal area lower than 12 m2.ha-1. This factor does not affect the increment estimations if the stand characteristics are close to mean value of the sample used to build the model (correction factor close to 1). The introduction in the model of competition indexes distance dependant or site qualitative variables does not significantly improve the growth model. [less ▲]Detailed reference viewed: 133 (15 ULiège) Optimizing treatment with thioguanine derivatives in inflammatory bowel disease.Louis, Edouard ; Belaiche, Jacques in Bailliere's Best Practice & Research. Clinical Gastroenterology (2003), 17(1), 37-46Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe ... [more ▼]Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe over the long term in patients who can tolerate them (80-90%). Recent progress in understanding the metabolism of these drugs and its implication in clinical practice have brought up new tools and strategies that are proposed to optimize treatment. In particular, the measurement and characterization of key enzymes and metabolites may have clinical impact. Thus, thiopurine methyl transferase genotyping and activity measurement, as well as erythrocytes, 6-thioguanine nucleotides and 6-methyl mercaptopurine levels, may help in some situations of intolerance or inefficacy with these drugs. Indications for starting and stopping treatment with thioguanine derivatives are also discussed. [less ▲]Detailed reference viewed: 26 (2 ULiège) Rivers, chemical weathering and Earth's climateDupre, B.; Dessert, C.; Oliva, P. et alin Comptes Rendus Geoscience (2003), 335(16), 1141-1160We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at ... [more ▼]We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at establishing chemical weathering laws for these two lithologies, describing the dependence of chemical weathering on environmental parameters, such as climate and mechanical erosion. As shown within this contribution, such mathematical laws are of primary importance for numerical models calculating the evolution of the partial pressure of atmospheric CO2 and the Earth climate at geological timescales. The major results can be summarized as follow: (1) weathering of continental basaltic lithologies accounts for about 30% of the total consumption of atmospheric CO2 through weathering of continental silicate rocks. This is related to their high weatherability (about eight times greater than the granite weatherability); (2) a simple weathering law has been established for basaltic lithologies, giving the consumption of atmospheric CO2 as a function of regional continental runoff, and mean annual regional temperature; (3) no such simple weathering law can be proposed for granitic lithologies, since the effect of temperature can only be identified for regions displaying high continental runoff; (4) a general law relating mechanical erosion and chemical weathering has been validated on small and large catchments. The consequences of these major advances on the climatic evolution of the Earth are discussed. Particularly, the impacts of the onset of the Deccan trapps and the Himalayan orogeny on the global carbon cycle are reinvestigated. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved. [less ▲]Detailed reference viewed: 51 (1 ULiège) Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphomaTilly, Hervé; Lepage, Eric; Coiffier, Bertrand et alin Blood (2003), 102(13), 4284-4289We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]Detailed reference viewed: 121 (0 ULiège) Basalt weathering laws and the impact of basalt weathering on the global carbon cycleDessert, C.; Dupre, B.; Gaillardet, J. et alin Chemical Geology (2003), 202(3-4), 257-273This study attempts to characterise the chemical weathering of basalts and to quantify the flux of carbon transferred from the atmosphere to the ocean during this major process at the surface of the Earth ... [more ▼]This study attempts to characterise the chemical weathering of basalts and to quantify the flux of carbon transferred from the atmosphere to the ocean during this major process at the surface of the Earth. To this aim, we have compiled different published chemical compositions of small rivers draining basalts. Basaltic river waters are characterised by relatively high Na-normalized molar ratios (Ca/Na: 0.2-3.9; HCO3/Na: 1-10; Mg/Na: 0.15-6) in comparison with those usually observed for river draining silicates. The data also show the climatic influence on basalt weathering and associated CO2 consumption. Runoff and temperature are the main parameters controlling the chemical weathering rate and derived CO2 consumption during basaltic weathering. From these relationships and digital maps, we are able to define the contribution of basalts to the global silicate flux. Taking account of this result, we estimate that the CO2 flux consumed by chemical weathering of basalts is about 4.08 x 10(12) mol/year. The fluxes from the islands of Indonesia and regions of central America represent around 40% of this flux. The global flux of CO2 consumed by chemical weathering of basalts represents between 30% and 35% of the flux derived from continental silicate determined by Gaillardet et al. [Chem. Geol. 159 (1999) 3]. Finally, it appears that volcanic activity not only acts as a major atmospheric CO2 source, but also creates strong CO2 sinks that cannot be neglected to better understand the geochemical and climatic evolution of the Earth. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]Detailed reference viewed: 44 (2 ULiège) Facteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : II) Franchissement des muqueuses et propriétés invasivesMainil, Jacques in Annales de Médecine Vétérinaire (2003), 147(3, JUN-JUL), 159-171Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, entero-haemorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains : adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This second manuscript presents the current knowledge on the transmucosal transfer, resistance to the bactericidal activity of the complement, resistance to phagocytosis and production of colicins, that were, for several years, considered as an important specific property of invasive strains of E coli. [less ▲]Detailed reference viewed: 48 (0 ULiège) (Ex)communicationDumortier, Jean-Louis in Lettre de la DLFM (2003), 32Detailed reference viewed: 10 (2 ULiège) Application of a damage model to an aluminium alloyCastagne, Sylvie; Habraken, Anne ; Cescotto, Serge in International Journal of Damage Mechanics (2003), 12(1), 5-30An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the ... [more ▼]An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the local approach of ductile fracture, effective stresses associated to damage variables are introduced. The damage law allows a continuous description of crack appearance. After a brief description of the model, its identification and its validation for an aluminum alloy are presented. Finally, the research of a global rupture criterion associated to this model is introduced. [less ▲]Detailed reference viewed: 57 (21 ULiège) The Sturtian 'snowball' glaciation: fire and iceGodderis, Y.; Donnadieu, Y.; Nedelec, A. et alin Earth And Planetary Science Letters (2003), 211(1-2), 1-12The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset ... [more ▼]The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset of large basaltic provinces between 825 and 755 Ma. Among these magmatic events, the most important one is the onset of a Laurentian magmatic province at 780 Ma around a latitude of 30degreesN. The presence of these fresh basaltic provinces increases the weatherability of the continental surfaces, resulting in an enhanced consumption of atmospheric CO2 through weathering, inducing a global long-term climatic cooling. Based on recent weathering laws for basaltic lithology and on climatic model results, we show that the weathering of a 6 x 10(6) km(2) basaltic province located within the equatorial region (where weathering of the province and consumption of CO2 are boosted by optimal climatic conditions) is sufficient to trigger a snowball glaciation, assuming a pre-perturbation PCO2 value of 280 ppmv. We show that the Laurentian magmatic province might be the main culprit for the initiation of the Sturtian 'snowball' glaciation, since the Laurentian magmatic province had drifted within the equatorial region by the time of the glaciation. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]Detailed reference viewed: 71 (6 ULiège) Les mycoplasmes respiratoires bovins: prévalence et propriétés de cyto-adhésionThomas, A.; Dizier, Isabelle ; SACHSE, K. et alin Annales de Médecine Vétérinaire (2003), 147(4), 267-272Detailed reference viewed: 23 (9 ULiège) Selection of the most efficient wavelength bands for 'Jonagold' apple sortingKleynen, O.; Leemans, Vincent ; Destain, Marie-France in Postharvest Biology & Technology (2003), 30(3), 221-232This paper presents a method based on quadratic discriminant analysis to select the best filters for detecting a wide range of defects in 'Jonagold' apple fruit using a multi-spectral vision system ... [more ▼]This paper presents a method based on quadratic discriminant analysis to select the best filters for detecting a wide range of defects in 'Jonagold' apple fruit using a multi-spectral vision system. Reflectance spectra of damaged and sound tissue were recorded using a visible/NIR spectrometer. Analysed defects consisted of scald, hail damage (with and without skin perforation), limb rubs, russets, scab tissue, frost damage, rot, visible flesh damage and recent bruises. Camera filter effects were approximated by summing the reflectances of all the wavelengths within the filter bandwidth. Combinations of three and four filters were tested and evaluated for discriminating damaged tissues from healthy ones. If a three-filter combination appeared sufficient to detect most of the damaged tissue, a four-filter combination should be considered for the complete sorting automation of this bicolour apple variety. A fourth filter was necessary to quantify the ratio between the blush and ground colours. Regarding recent bruise defects which represented the major difficulty, an image segmentation algorithm based on local contrast variations can enhance their detection. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]Detailed reference viewed: 58 (4 ULiège) Chemistry of silica at different concentrations of non-ionic surfactant solutions: Effect of pH of the synthesis gel on the preparation of mesoporous silicasLéonard, Alexandre ; Blin, J. L.; Jacobs, P. A. et alin Microporous and Mesoporous Materials (2003), 63(1-3), 59-73Ordered and disordered mesoporous silicas have been synthesized through an assembly of non-ionic decaoxyethylene cetyl ether [C 16(EO) 10] and a tetramethoxysilane silica source by variation of the pH ... [more ▼]Ordered and disordered mesoporous silicas have been synthesized through an assembly of non-ionic decaoxyethylene cetyl ether [C 16(EO) 10] and a tetramethoxysilane silica source by variation of the pH value of the synthesis gel. The structure, texture and morphology of the mesoporous silicas, synthesized with concentrated and diluted surfactant solutions, have been discussed from the perspective of silica's chemistry upon a variation of pH values of the synthesis gel (micellar solution). With concentrated surfactant solutions (50 wt%), disordered compounds are obtained in a range of pH from 2.0 to 7.0 (micellar solution). As the pH increases, however, the pore size distributions (PSD) become broader and bimodality appears due to the micelle-templated silica (MTS) mesopores and openings arising from silica dissolution-reprecipitation processes. Also, the MTS pores expand due to a change in conformation of the surfactant hydrophilic head upon pH increase. On the other hand, diluted surfactant solutions (10 wt%) lead to ordered materials in a pH range from 2.0 to 7.0 (synthesis gel). The PSD remain very narrow but interparticular porosity appears and the morphologies undergo deep changes from toroids, gyroids and ropes to aggregates of very small particles with increasing pH. © 2003 Elsevier Inc. All rights reserved. [less ▲]Detailed reference viewed: 15 (1 ULiège) Long-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation.Schetelig, Johannes; Fetscher, Sebastian; Reichle, Albrecht et alin Haematologica (2003), 88(11), 1272-8BACKGROUND AND OBJECTIVES: Patients with angioimmunoblastic T-cell lymphoma (AIL) have a poor prognosis with conventional treatment. DESIGN AND METHODS: We initiated an EBMT-based survey studying the ... [more ▼]BACKGROUND AND OBJECTIVES: Patients with angioimmunoblastic T-cell lymphoma (AIL) have a poor prognosis with conventional treatment. DESIGN AND METHODS: We initiated an EBMT-based survey studying the impact of high-dose chemotherapy (HDCT) and autologous hematopoietic stem cell transplantation in patients with AIL. Data on 29 patients, who were transplanted between 1992 and 1998 in 16 transplant centers, were collected on standardized documentation forms. RESULTS: The median age at transplantation was 53 years. HDCT was given as part of 1st-line therapy (N=14; 48%) or 2nd/3rd-line therapy (N=15; 52%). Regimens for the mobilization of peripheral blood stem cells (PBSC) included VIPE (N=7; 26%), DexaBEAM (N=6; 22%), CHOP-like regimens (N=6; 22%), other regimens (N=5; 19%) or alternatively growth factor alone (N=3; 11%). The median yield of PBSC was 3.8x106 CD34+cells/kg. Two patients received autologous bone marrow. The HDCT consisted of BEAM-type regimens in 16 patients, ICE-type regimens in 7, and other regimens in 6 patients. There was one treatment-related death. The rate of complete remissions increased from 45% before HDCT to 76% after HDCT. As of January 2003, after a median observation time of living patients of 5 years (range 2.5 to 10 years), 14 patients have died (13 from progressive disease), and 15 patients are alive. The probability of 5-year overall and event-free survival was 44% (95% CI, 22% to 66%) and 37% (95% CI, 17% to 57%), respectively. Long-term disease-free survival was observed in patients transplanted during 1st-line treatment as well as in the context of 2nd/3rd-line therapy. INTERPRETATION AND CONCLUSIONS: There is evidence that AIL is susceptible to high-dose chemotherapy. HDCT and autologous stem cell transplantation should be considered in selected patients with AIL. [less ▲]Detailed reference viewed: 125 (0 ULiège) Une approche par les compétences pour l’apprentissage des soins infirmiers. Analyse des pratiques des enseignants.Dury, Cécile in Recherche en Soins Infirmiers (2003), 73(Juin), 4-40The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non ... [more ▼]The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non-directive approach. The data were analysed with a qualitative method: "structural analysis method". The results showed that their methods are in majority in a transmissive and behavioral model; an inadequacy between teaching methods and pedagogical goals; an abivalent and unclear understanding of their role; a lack of coherence in the assesment methods. To conclude, various strategies are proposed on institutional and national levels to support the implementation of a competence-based approach in nursing training. [less ▲]Detailed reference viewed: 3155 (10 ULiège) Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways.Faveeuw, Christelle; Gosset, Philippe; Bureau, Fabrice et alin European Journal of Immunology (2003), 33(4), 889-898Prostaglandin (PG) D(2), and its metabolites, are known to be important mediators during acute and chronic inflammation. However, their functions during the early phases of the immune response are poorly ... [more ▼]Prostaglandin (PG) D(2), and its metabolites, are known to be important mediators during acute and chronic inflammation. However, their functions during the early phases of the immune response are poorly documented. In the present study, we show that PGD(2 )inhibits, in a dose-dependent manner, the CD40- and LPS-induced secretion of the Th1-driving factor IL-12 by murine splenic dendritic cells (DC), the most potent antigen-presenting cells. The inhibition of IL-12 production is mediated only in part by the cell surface G alpha s protein-coupled D prostanoid receptor (termed DP1) but not by the G alpha i protein-coupled DP receptor, DP2. We show that recruitment of DP1 in DC results in the activation of a cyclic AMP/protein kinase A pathway that is partially responsible for the inhibition of IL-12 production. We also suggest that the DP1-independent effects exerted by PGD(2) on IL-12 production may be due to the action of ist PGJ(2), but not PGF(2)alpha, metabolites. Electrophoretic mobility shift assays demonstrated that PGD(2) affects NF-kappa B activation through (the) DP1-independent pathway(s). Together these data suggest that PGD(2), by interacting with DP1 and by binding to other target cellular proteins, may regulate immune responses by affecting IL-12 production in DC [less ▲]Detailed reference viewed: 34 (1 ULiège) Effect of rival males on the courtship of paedomorphic and metamorphic Triturus alpestris (Amphibia : Salamandridae)Denoël, Mathieu in Copeia (2003), 2003(3), 618-623Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and ... [more ▼]Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and salamanders is a suitable process to explore this question because it implies the coexistence of two different morphological morphs differing by the presence of gills and epigamic traits. The aim of this study was to find out whether paedomorphs and metamorphs use similar tactics to attract mates in the presence of a rival and whether there are differences in sexual activity and success between alternative morphs. Sexual interactions in triadic encounters were staged and analyzed in a standardized experimental design. The two kinds of males did not differ in terms of sexual activity, spermatophore deposition or female responsiveness. Both rival paedomorphic and metamorphic males exhibited sexual interference, but in most encounters, intruders just disturbed the courting pair. Sperm transfer success was lower in triadic encounters than in dyadic encounters. These results illustrate that intermorph breeding also occurs in the presence of competitors but that the success rate of the newts is considerably decreased in such competitive situations. Moreover, newts do not use alternative reproductive tactics depending on their status (i.e., paedomorph or metamorph). [less ▲]Detailed reference viewed: 113 (9 ULiège) Recombinant human erythropoietin therapy is very effective after an autologous peripheral blood stem cell transplant when started soon after engraftment.Baron, Frédéric ; Frere, Pascale ; Fillet, Georges et alin Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2003), 9(15), 5566-72PURPOSE: Previous trials of recombinant human erythropoietin (rHuEpo) therapy after autologous hematopoietic stem cell transplantation have administered very high doses of i.v. rHuEpo starting on day 1 ... [more ▼]PURPOSE: Previous trials of recombinant human erythropoietin (rHuEpo) therapy after autologous hematopoietic stem cell transplantation have administered very high doses of i.v. rHuEpo starting on day 1 and continuing for 1-2 months until erythroid engraftment and have shown no benefit of rHuEpo therapy. We sought to establish a more effective use of rHuEpo in this setting. EXPERIMENTAL DESIGN: In this report, we show in a first cohort of 45 lymphoma or myeloma patients undergoing peripheral blood stem cell transplant (control group) that endogenous erythropoietin levels are high for the degree of anemia during the first 3 weeks after transplant but become adequate or slightly decreased thereafter. We thus enrolled 41 consecutive similar patients in a trial of rHuEpo therapy at a dose of 500 units/kg/week started on day 30 after the transplant. RESULTS: The 12-week probability of achieving hemoglobin (Hb) levels of 13 g/dl was 87% in rHuEpo-treated patients versus 14% in controls (P = 0.0001). Mean Hb levels were significantly higher in the rHuEpo group than in the control group from day 42 through day 150 after transplant (Ps of <0.05 to <0.001). Two of 41 patients in the rHuEpo group versus 12 of 45 patients in the control group had Hb levels of <9 g/dl between day 42 and day 100 after the transplant (P = 0.0078). CONCLUSIONS: Anemia after autologous peripheral blood stem cell transplant is exquisitely sensitive to rHuEpo when therapy is started soon after engraftment. This is the first convincing report showing that rHuEpo is effective in this setting. Our data set the stage for a more rational use of rHuEpo after autologous hematopoietic stem cell transplantation and should renew interest in erythropoietin therapy in this setting. Prospective, randomized trials should investigate the impact of rHuEpo therapy on transfusion requirements and quality of life. [less ▲]Detailed reference viewed: 33 (0 ULiège) The use of blood pepsinogen as a biomarker of the integrity of the porcine gastric mucosa. 2. Measurements of blood pepsinogen and its usefull in the detection of gastric diseasesBanga-Mboko, Henri; Godeau, Jean-Marie ; Drion, Pierre et alin Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 95-104Pepsinogen is one component of the gastric juice which participes in the digestion. This macromolecule enters the blood circulation in a small measurable quantities in healthy subjects. Therefore, blood ... [more ▼]Pepsinogen is one component of the gastric juice which participes in the digestion. This macromolecule enters the blood circulation in a small measurable quantities in healthy subjects. Therefore, blood pepsinogen is claimed to be an indicator of the integrity of the gastric mucosa. This paper was written to review the use of porcine in the diagnostic of stomach ulcers and Hyostrongylus rubidus infection. The methods of measurement of blood pepsinogen and the diagnostic values are discussed. [less ▲]Detailed reference viewed: 66 (4 ULiège) Competition Policy and the Euromed PartnershipPetit, Nicolas ; Geradin, Damienin European Foreign Affairs Review (2003)This paper seeks to provide a critical assessment of the efforts made by the EC to stimulate the development of competition laws in the Mediterranean countries with which it is engaged in partnership ... [more ▼]This paper seeks to provide a critical assessment of the efforts made by the EC to stimulate the development of competition laws in the Mediterranean countries with which it is engaged in partnership agreements. It reviews the content of the competition provisions of the association agreements, as well as their effectiveness. In then examines the regular calls for convergence on the EC competition law model to which Mediterranean countries are object. There is indeed room for debate regarding the opportunity, as well as the nature of such convergence. The paper concludes that a deep convergence approach, whereby the non-candidate Partner countries would transpose EC competition rules in their domestic legal order, would provide many benefits for both the EC and these countries. [less ▲]Detailed reference viewed: 56 (5 ULiège) Mycoplasma bovis dans le complexe respiratoire bovin et propriétés de cyto-adhésion in vitroThomas, Anne; Dizier, Isabelle ; Sachse, K. et alin Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 267-272Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This ... [more ▼]Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This species was frequently isolated in Belgium from cattle with respiratory disease. Furthermore, associations were often observed with pasteurellas and bovine respiratory syncytial virus. Of these M. bovis isolates, many were resistant to several antimicrobial agents which are used in cattle practice, except to fluoroquinolones. Inasmuch the high frequency of M. bovis isolation and antibiotic resistances, it is very important to understand the pathogenicity of this bacteria in order to optimize prophylactic tools. Therefore, the study of the cytadherence of M. bovis is essential since it represents the first step of the bacterial infection. According to our experimental results, PG45 is not representative of field isolates because of its low adherence rates to various cell lines. This could be explained by the high number of subcultures of this pathogenic strain underwent since its first isolation, which sharply contrasts with other isolates. M. bovis adheres specifically to bovine bronchial epithelial cells in primary culture. Proteins such as variable surface proteins C and F are involved in this step as observed by decreased adherence rates after trypsinization of mycoplasma cells or addition of monoclonal antibodies. [less ▲]Detailed reference viewed: 133 (11 ULiège) Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells.Gosset, Philippe; Bureau, Fabrice ; Angeli, Veronique et alin Journal of Immunology (2003), 170(10), 4943-52Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2 ... [more ▼]Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2) are in part effected through two plasma membrane G protein-coupled receptors: the D prostanoid (DP) receptor and the chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTH2). In this report, we studied the effects of PGD(2) and of its major physiological metabolite, 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), on the functions of human monocyte-derived DC. First, we show that PGD(2) exerts in vitro chemotactic effects on monocytes via CRTH2 activation while it inhibits the chemokine-driven migration of monocyte-derived DC through DP. We also report that PGD(2) and 15d-PGJ(2) alter the LPS- and allergen-induced DC maturation and enhance the CD80/CD86 ratio on mature DC in a DP- and CRTH2-independent manner. Moreover, PGD(2) and 15d-PGJ(2) strongly reduce the secretion of the Th1 promoting cytokine IL-12 and affect the synthesis of chemokines involved in Th1 cell chemotaxis, particularly CXCL10. Inhibition of cytokine/chemokine secretion implicates at least in part DP, but not CRTH2. The effects exerted by PGD(2) are associated with the phosphorylation of CREB, but do not parallel with the deactivation of the NF-kappa B and mitogen-activated protein kinase pathways. In contrast, 15d-PGJ(2) seems to target other cellular proteins. Finally, in a model of Th CD45RA(+) differentiation induced by allergen- and superantigen-pulsed DC, PGD(2) impacts on the orientation of the immune response by favoring a Th2 response [less ▲]Detailed reference viewed: 39 (5 ULiège) SHIP2 et signalisation de l'insuline: quel role dans la pathogenese et le traitement du diabete de type 2?Schurmans, Stéphane in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2003), 158(7-9), 335-9Based on the analysis of SHIP2+/- and SHIP2-/- mice showing that the lipid phophatase SHIP2 is an important negative regulator of the insulin pathway, we have suggested that the enzyme is a candidate gene ... [more ▼]Based on the analysis of SHIP2+/- and SHIP2-/- mice showing that the lipid phophatase SHIP2 is an important negative regulator of the insulin pathway, we have suggested that the enzyme is a candidate gene for genetic predisposition to type 2 diabetes, and a potential therapeutic target for the same disease. Two years after, we propose to review these hypothesis in light of recent results from our laboratory, from international collaborations and from competitors in the field. [less ▲]Detailed reference viewed: 23 (2 ULiège) Finding the lost Iris sofarana FosterSaad, Layla in Aril Society International Yearbook (2003)Detailed reference viewed: 53 (2 ULiège) Dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation periodDebier, Cathy; Pomeroy, Paddy P.; Dupont, Cédric et alin Marine Ecology-Progress Series (2003), 247The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber ... [more ▼]The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber, maternal serum, milk and pup serum. Mother-pup pairs were captured regularly between birth and weaning on the Isle of May, Scotland. The PCB profiles of the different compartments of transfer consisted mainly of congeners 153, 138, 180, 187, 170 and 101, which made up 85% of the total PCB burden. Outer blubber contained higher relative concentrations (R-153) Of hepta-, octa-, and nona-chlorinated congeners (higher chlorinated congeners) than inner blubber, at both early (less than or equal to 5 d) and late (greater than or equal to 11 d) lactation. There was no change in the composition of the outer blubber layer between early and late lactation, while in the inner blubber, there was a slight increase in the R153 of higher chlorinated congeners at late lactation. In maternal serum, profiles changed towards having a higher proportion of higher chlorinated congeners as lactation progressed, but in milk, the PCB pattern stayed constant throughout lactation. Surprisingly, in pup serum profiles also changed towards higher R153 of higher chlorinated congeners at late lactation compared to early lactation, which was different to the pattern observed in milk. In all body compartments, higher proportions of higher chlorinated congeners were associated with higher concentrations of total PCBs. Maternal blubber and pup serum contained a higher R153 of higher chlorinated congeners than milk and, to a lesser extent, maternal serum. Thus biomagnification of the higher chlorinated congeners was recorded in pup serum. [less ▲]Detailed reference viewed: 18 (0 ULiège) Commentaires sur la correction d'un travail écritDumortier, Jean-Louis in Puzzle (2003), 14Detailed reference viewed: 54 (4 ULiège) In vitro paradigms for the study of GnRH neuron function and estrogen effects.Matagne, Valerie; LEBRETHON, Marie-Christine ; Gerard, Arlette et alin Annals of the New York Academy of Sciences (2003), 1007The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency ... [more ▼]The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency of GnRH secretion, the excitatory effect of glutamate, and the inhibitory or excitatory effect of GABA. Among the different paradigms, the fetal olfactory placode cultures exhibit the unique property of migration in vitro and may retain the capacity to undergo maturational changes in vitro. The short-term incubation of hypothalamic explants obtained at different ages enables one to study developmental changes as well. Estrogens may have important roles in the regulation of GnRH function and can act indirectly via the neighboring neuronal/glial apparatus and directly on GnRH neurons at the cell body and terminal levels. A direct effect is supported by the recent localization of ERalpha and ERbeta transcripts in GnRH neurons using most paradigms. Discrepant effects of estrogens on GnRH neurons were observed since GnRH biosynthesis is inhibited while GnRH secretion can be either stimulated, unaffected, or reduced. It is likely that the regulatory role of sex steroids including estradiol is very complex since it could involve direct and indirect effects on GnRH neurons through genomic and/or non-genomic mechanisms. [less ▲]Detailed reference viewed: 17 (0 ULiège) Sur quoi les professeurs devraient-ils s'accorder pour que convergent leurs efforts lorsqu'ils fabriquent et emploient des outils d'évaluation de compétences en lecture ?Dumortier, Jean-Louis in Puzzle (2003), 13Detailed reference viewed: 12 (0 ULiège) L'air du temps : Un souffle d'oxygène pour des collections d'horlogerieDrouguet, Noémie in Art&Fact (2003), 22Detailed reference viewed: 16 (3 ULiège) Prediction of organoleptic and technological characteristics of pork meat by near infrared spectroscopyMeulemans, A.; Dotreppe, Olivier ; Leroy, Bernadette et alin Sciences des Aliments (2003), 23(1), 159-162Detailed reference viewed: 87 (6 ULiège) Un acte de mécénat d'Aubert Le Mire (1573-1640) en faveur des Dominicains de BruxellesAdam, Renaud in Revue du Cercle d'Histoire de Bruxelles et Extensions (2003), 79Detailed reference viewed: 25 (2 ULiège) Enseigner autrement : une expérience à l’Université de LiègeMerenne-Schoumaker, Bernadette in Géographes Associés (2003), (27), 183-184Analyse d'une expérience en pédagogie active développée dans le cadre du cours de géographie urbaine à l'Université de LiègeDetailed reference viewed: 55 (6 ULiège)