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See detailUncoupling protein and alternative oxidase of Dictyostelium discoideum: occurrence, properties and protein expression during vegetative life and starvation-induced early development.
Jarmusszkiewicz, W.; Behrendt, M.; Navet, R. et al

in FEBS Letters (2002), 532

In this study we show that mitochondria of Dictyostelium discoideum contain both alternative oxidase (AOX) and uncoupling protein (UCP). AOX was stimulated by purine mononucleoside and was monomeric. UCP ... [more ▼]

In this study we show that mitochondria of Dictyostelium discoideum contain both alternative oxidase (AOX) and uncoupling protein (UCP). AOX was stimulated by purine mononucleoside and was monomeric. UCP was stimulated by free fatty acids and was poorly sensitive to GTP. Both proteins collaborated in energy dissipation when activated together. AOX expression in free-living ameboid cells decreased strongly from exponential to stationary phase of growth but much less during starvation-induced aggregation. In contrast, UCP expression was constant in all conditions indicating permanent need. Our results suggest that AOX could play a role in cell differentiation, mainly by protecting prespore cells from programmed cell death. [less ▲]

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See detailUse of Anesthesia Simulator
Pendeville, Philippe; Mayne, Alain; LARBUISSON, Robert ULg et al

in Benelux quaterly journal on automatic control (2002), 43(2), 17-19

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See detailVegetative and generative behaviour of Strawberry (Fragaria x ananassa Duch.) plants raised from in vitro regeneration of axillary or stipular buds
Jemmali, Ahmed; Elloumi, Nedra; Kevers, Claire ULg

in Acta Botanica Gallica : Bulletin de la Société Botanique de France (2002), 149(4), 395-404

In vitro regeneration of strawberry (Fragaria x ananassa Duch.) plants from adventitious stipular buds allowed us to obtain a new clone differing from the axillary originated clone by its vegetative and ... [more ▼]

In vitro regeneration of strawberry (Fragaria x ananassa Duch.) plants from adventitious stipular buds allowed us to obtain a new clone differing from the axillary originated clone by its vegetative and reproductive behavior. Besides of its clear and rounded leaves, this clone is characterized by a slower plastochronal rythm corresponding to the production of a greater number of axillary shoots (runners). Furthermore, its flowers have shorter receptacle that does not overstep stamens. At the contrary, receptacle of the axillary clone largely overstep stamens and then, they are not well pollinated and resulted in malformed fruits especially in cold season or in absence of pollen vectors. [less ▲]

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See detailEffect of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice.
Tibor, Anne; Wansard, Valerie; Bielartz, Valery et al

in Infection and Immunity (2002), 70(10), 5540-6

The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and ... [more ▼]

The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new family of outer membrane proteins specifically encountered in the family RHIZOBIACEAE: We evaluated the impact of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. The omp10 mutant was dramatically attenuated for survival in mice and was defective for growth in minimal medium but was not impaired in intracellular growth in vitro, nor does it display clear modification of the outer membrane properties. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B. abortus. [less ▲]

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See detailLes adhésifs de cinquième génération
Gueders, Audrey ULg

in Actualités Dentaires de l'Université de Liège (2002), 30

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See detailInventories and Maps: Cognitive Ways of Framing the Nature Policies in Europe
Mougenot, Catherine ULg; Remy, Elisabeth

in Journal of Environmental Policy & Planning (2002), 4(4), 313-322

Since the Earth Summit in Rio, declining biodiversity has become a subject of general concern for many countries. To counter these negative trends, government nature policies in Europe at least are now ... [more ▼]

Since the Earth Summit in Rio, declining biodiversity has become a subject of general concern for many countries. To counter these negative trends, government nature policies in Europe at least are now thought out primarily in terms of networks. They concern new areas outside nature reserves, new players and new management strategies. Consequently, these policies should themselves become the subject of new public debate. Our study concerns the analysis of the forms used to collect the data required to set up the European Union's Natura 2000 network and maps drawn as part of the Council of Europe's Pan-European Ecological Network strategy. The aim of this article, which takes the perspective developed by the sociology of science, will be to show how the forms and maps used in these new nature policies produce knowledge that precedes policy discussions to search for the best possible socio-political compromises. In other words, the knowledge that is collected in and by means of these documents, forms and maps offers a cognitive way of framing the subsequent public debates. [less ▲]

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See detailLe vers semi-libre d'Yves Bonnefoy dans 'Ce qui fut sans lumiere'
Purnelle, Gérald ULg

in Français Moderne (Le) (2002), 70(2), 145-168

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See detailIdentification d'une loi thermo-élasto-viscoplastique en vue de la modélisation du laminage à chaud du cuivre
Moureaux, P.; Moto Mpong, S.; Remy, M. et al

in Journal de Physique IV (2002), 102

la mise au point d'un modèle de simulation de la dernière passe du laminage à chaud du cuivre ne présente à priori pas de problème du point de vue numérique pour un code d'éléments finis non linéaire. La ... [more ▼]

la mise au point d'un modèle de simulation de la dernière passe du laminage à chaud du cuivre ne présente à priori pas de problème du point de vue numérique pour un code d'éléments finis non linéaire. La collecte d'informations précises tant sur le procédé industriel que sur le comportement du matériau est par contre une opération non triviale. Cet article présente les diverses méthodes expérimentales mises en œuvre pour caractériser le matériau: essais de compression à chaud, mesures d'analyse thermique différentielle, essais de dilatométrie et de diffusivité. Les méthodes permettant d'identifier les paramètres de la loi élasto-visco-plastique de type Norton-Hoff à partir des essais sont présentées et une analyse bibliographique investigue le problème de la détermination du module de Young à haute température. Tant les hypothèses supplémentaires relatives au procédé et nécessaires au modèle que les résultats finaux sont résumés. [less ▲]

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See detailLe médicament du mois. Le tacrolimus topique (Protopic).
Pierard, Gérald ULg; Pierard, Claudine ULg; Paquet, Philippe ULg

in Revue Médicale de Liège (2002), 57(8), 552-5

Tacrolimus is a potent inhibitor of immune mechanisms. It belongs to the macrolactam group. It inhibits the release of both Th1 and Th2 cytokines. It proves to be efficacious after topical application in ... [more ▼]

Tacrolimus is a potent inhibitor of immune mechanisms. It belongs to the macrolactam group. It inhibits the release of both Th1 and Th2 cytokines. It proves to be efficacious after topical application in the treatment of atopic dermatitis. In this indication, tacrolimus challenges topical corticosteroids. Irritation risks are present. The local immuno-depression can boost disseminated infections including herpes. The risk to promote photocarcinogenesis on the long term, and that bound to chronic resorption remain theoretical concerns that have not been assessed so far. [less ▲]

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See detailEst-il déraisonnable de ne pas accorder une pension de survie au compagnon du travailleur décédé ?
Michiels, Olivier ULg; Joskin, Véronique

in Revue Trimestrielle de Droit Familial (2002), (1), 161-166

L'article envisage la question de savoir si le compagnon qui formait un ménage avec un travailleur décédé est en droit de pouvoir revendiquer une pension de survie.

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See detailSynthesis of 2-amino-1,4-dihydro-4-quinolinones and diaminomethylene Meldrum’s acids derivatives as potential potassium channel openers
Erb, B.; Rigo, B.; Pirotte, Bernard ULg et al

in Journal of Heterocyclic Chemistry (2002), 39

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See detailPrenons garde aux lésions kystiques cutanées. Du dérisoire au méritoire.
Hermanns-Lê, Trinh ULg; Hermanns, Jean-François ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(5), 314-6

Cutaneous cystic-like lesions do not always correspond to real epithelial cysts. Indeed, the histological examination may identify another benign tumour. But, in some instances, the surprise may be ... [more ▼]

Cutaneous cystic-like lesions do not always correspond to real epithelial cysts. Indeed, the histological examination may identify another benign tumour. But, in some instances, the surprise may be greater. We report three patients in whom lesions suggested clinically small cysts. However, they were malignant neoplasms corresponding to a malignant fibrous histiocytoma, an epithelioid angiosarcoma and a metastatic adenocarcinoma, respectively. [less ▲]

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See detailDirect effect of ice sheets on terrestrial bicarbonate, sulphate and base cation fluxes during the last glacial cycle: minimal impact on atmospheric CO2 concentrations
Tranter, Martyn; Huybrechts, Philippe; Munhoven, Guy ULg et al

in Chemical Geology (2002), 190(1-4), 33-44

Chemical erosion in glacial environments is normally a consequence of chemical weathering reactions dominated by sulphide oxidation linked to carbonate dissolution and the carbonation of carbonates and ... [more ▼]

Chemical erosion in glacial environments is normally a consequence of chemical weathering reactions dominated by sulphide oxidation linked to carbonate dissolution and the carbonation of carbonates and silicates. Solute fluxes from small valley glaciers are usually a linear function of discharge. Representative glacial solute concentrations can be derived from the linear association of solute flux with discharge. These representative glacial concentrations of the major ions are similar to 25% of those in global river water. A 3-D thermomechanically coupled model of the growth and decay of the Northern Hemisphere ice sheets was used to simulate glacial runoff at 100-year time steps during the last glacial cycle (130 ka to the present). The glacially derived fluxes of major cations, anions and Si over the glaciation were estimated from the product of the glacial runoff and the representative glacial concentration. A second estimate was obtained from the product of the glacial runoff and a realistic upper limit for glacial solute concentrations derived from theoretical considerations. The fluxes over the last glacial cycle are usually less than a few percent of current riverine solute fluxes to the oceans. The glacial fluxes were used to provide input to an oceanic carbon cycling model that also calculates changes in atmospheric CO2. The potential change in atmospheric CO2 concentrations over the last glacial cycle that arise from perturbations in glacial solute fluxes are insignificant, being < 1 ppm. [less ▲]

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See detailSex control and sex determinism study in Eurasian perch, Perca fluviatilis, by use of hormonally sex-reversed male breeders
Rougeot, Carole ULg; Jacobs, Bruno; Kestemont, Patrick et al

in Aquaculture (2002), 121

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See detailIdentification of bioindicator species among Ephemeroptera, Plecoptera and Trichoptera in a survey of streams belonging to the rhithral classification in the Grand Duchy of Luxembourg
Dohet, A.; Dolisy, D.; Hoffmann, L. et al

in Verhandlungen der Internationalen Vereinigung für Theoretische und Angewandte Limnologie = Proceedings of the International Association of Theoretical and Applied Limnology (2002), 28

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See detailMigraines et vertiges, une relation à vous faire tourner la tête
FUMAL, Arnaud ULg; Schoenen, Jean ULg

in Migraine Contact (2002), 2

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See detailDesign of structural joints in building frames
Jaspart, Jean-Pierre ULg

in Progress in Structural Engineering and Materials (2002), 4(1), 18-34

A single and unified concept for the design of structural joints in building frames made of any material has been developed in recent years, and is now widely implemented in European design codes. In the ... [more ▼]

A single and unified concept for the design of structural joints in building frames made of any material has been developed in recent years, and is now widely implemented in European design codes. In the present paper, this concept is presented, its merits as far as the economy of a project are demonstrated, and practical design tools for its application in daily practice are briefly described. The paper also contains references to user's manuals and design handbooks. [less ▲]

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See detailSmearing scheme for finite-temperature electronic-structure calculations
Verstraete, Matthieu ULg; Gonze, X.

in Physical Review. B : Condensed Matter (2002), 65

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See detailAlchimie défaillante des cytokines dans l'ulcère chronique de jambe.
Franchimont, Claudine ULg; Henry, Frédérique ULg; Paquet, Philippe ULg et al

in Skin Pharmacology : The Official Journal of the Skin Pharmacology Society (2002), 5

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See detailQuels espoirs de remyélinisation dans la sclérose en plaques ?
Rogister, Bernard ULg; Wislet, Sabine ULg; Belachew, Shibeshih ULg

in Agenda Psychiatrie (L') (2002), 24

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See detailRunoff control of soil degassing at an active volcano. The case of Piton de la Fournaise, Reunion Island
Toutain, J. P.; Baubron, J. C.; François, Louis ULg

in Earth And Planetary Science Letters (2002), 197(1-2), 83-94

Airborne atmospheric and in-situ soil gas analyses demonstrate that distal gas leaks are non-existent at Piton de la Fournaise (PF) despite frequent eruptions. Airborne traverses made at a constant ... [more ▼]

Airborne atmospheric and in-situ soil gas analyses demonstrate that distal gas leaks are non-existent at Piton de la Fournaise (PF) despite frequent eruptions. Airborne traverses made at a constant altitude indicated that no detectable large-scale CO2 degassing occurs from the volcano. In-situ soil gas traverses (CO2, He-4, Rn-222) across the active riftzones, the summit crater and the caldera rims, show both a lack of positive anomalies and evidence of strong depleted concentrations for He and CO2 with respect to air. Depletions in soil He is explained by intense rain water infiltration. A more unexpected result lies in the very low CO2 concentrations (down to 92 ppm) in bare soils in the summit region. Such a depletion was not previously reported and is attributed to considerable basalt weathering operating as the result of huge runoff. A model has enabled both the runoff and the CO2 consumption occurring within the basaltic layers to be calculated. Data obtained are consistent with values expected from large-scale erosion models and with the local calculated diffusive flux of CO2 in soils. The huge runoff, together with the basaltic lithology of the volcano, are found to be the main factor controlling the soil gas signatures at PF. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailHartree-Fock instabilities: Relation between an artifact and some properties.
Dehareng, Dominique ULg; Dive, Georges ULg; Geron, Christine

in Recent Research Development in Chemical Physics (2002), 3

The Hartree-Fock instability problem is reviewed and some of the instabilities are put in relation with particular properties of the system.

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See detailFeasibility of a Walloon test-day model and study of its potential as tool for selection and management
Auvray, B.; Gengler, Nicolas ULg

in Interbull Bulletin (2002), 29

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See detailAg/SiO2 and Cu/SiO2 cogelled xerogel catalysts for benzene combustion and 2-butanol dehydrogenation
Lambert, Stéphanie ULg; Tcherkassova, Natalia; Cellier, Caroline et al

in Studies in Surface Science and Catalysis (2002), 143

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See detailL’entomophagie : une question de culture ?
Mignon, Jacques ULg

in Tropicultura (2002), 20(3), 151-155

Entomophagy: How to Overcome our European Aversion? Entomophagy, the eating of insects, is not a curiosity but is practiced throughout the world, except in Europe and in North-America. For many Europeans ... [more ▼]

Entomophagy: How to Overcome our European Aversion? Entomophagy, the eating of insects, is not a curiosity but is practiced throughout the world, except in Europe and in North-America. For many Europeans, the consumption of insects is considered as a primitive and a repugnant comportment. An experiment, conducted in Belgium (Gembloux) has shown that, informed about the cultural, the nutritional and the ecological aspects of entomophagy, Westerners are able to surmount their aversion. Could insects become common dish in European and American restaurants? [less ▲]

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See detailL'intensité des soins en gériatrie : élaboration d'un document de réflexion
Petermans, Jean ULg

in Revue Médicale de Bruxelles (2002), 23

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See detailSwaged bolts: modelling of the installation process and numerical analysis of the mechanical behaviour
Drean, M.; Habraken, Anne ULg; Bouchaïr, A. et al

in Computers & Structures (2002), 80

Swaged bolts are an alternative to high strength bolts in steel structures. To clarify the steps of the installation process, numerical modelling has been carried out. The relevant phenomena are described ... [more ▼]

Swaged bolts are an alternative to high strength bolts in steel structures. To clarify the steps of the installation process, numerical modelling has been carried out. The relevant phenomena are described and evaluated. This numerical calculation accounts for large displacements, large strains, mechanical plasticity and friction contact between the components of swaged bolts. The non-linear finite element code ‘‘Lagamine’’ designed for the simulation of metal forming processes has been used to provide the stress distributions in the components. [less ▲]

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See detailAssessment of milk yield losses and subclinical mastitis risk factors using bulk milk somatic cell counts in dairy herds
Mtaallah, Brahim; Oubey, Zied; Hammami, Hedi ULg

in Revue de Médecine Vétérinaire (2002), 153(4), 251-260

A prospective study, involving 21 selected dairy farms in north of Tunisia, was conducted to asses the loss of milk production due to high levels bulk tank somatic cell count and to find some relationship ... [more ▼]

A prospective study, involving 21 selected dairy farms in north of Tunisia, was conducted to asses the loss of milk production due to high levels bulk tank somatic cell count and to find some relationship between risk factors and subclinical mastitis. We found that the mean of bulk milk somatic cell count was 626 103 cell/ml. Using a simple statistical model, the average loss of milk due to levels bulk tank somatic cell count was 524 kg per cow per year. Using method of mean comparisons, risk factors associated to high levels bulk tank somatic cell count was: Livestock farming risk factors : inadequacy bedding area; inadequacy cleaning bedding and scrapping area. Milking risk factors : washing teat with a shower no adjustable flow and without wipe with individuel towel milk shift work above five per cow-herd; no stripping squirts of milk before milking; milking healthy and mastitis cows at the same time; no teat dipping. [less ▲]

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See detailThermo-hydro-mechanical coupling in clay barriers
Collin, Frédéric ULg; Li, Xian-Ling; Radu, Jean-Pol ULg et al

in Engineering Geology (2002), 64(2-mars Sp. Iss. SI),

A thermo-hydro-mechanical model is presented to tackle the complex coupling problems encountered in clay barriers. A detailed formulation. coupling heat, moisture (liquid water and water vapour) and air ... [more ▼]

A thermo-hydro-mechanical model is presented to tackle the complex coupling problems encountered in clay barriers. A detailed formulation. coupling heat, moisture (liquid water and water vapour) and air transfer in a deformable unsaturated soil is given. The formulation of Alonso-Gens' mechanical model for unsaturated soil is also incorporated. Finally, a small-scale wetting-heating test on compacted bentonite is performed for validation; the numerical results are compared to the experimental measurements. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMechanical behaviour of Lixhe chalk partly saturated by oil and water: experiment and modelling
Collin, Frédéric ULg; Cui, Yu Jun; Schroeder, Christian ULg et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2002), 26(9), 897-924

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical ... [more ▼]

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical behaviour of a chalk saturated by two non-miscible fluids, water and oil. The effects of the capillary pressure or suction are taken into account. They are considered as an independent variable, as in the Barcelona's basic model developed for unsaturated soils. On the other hand, internal friction and pore collapse are modelled as independent mechanisms. The determination of the parameters is based on triaxial and oedometer tests. Finally, in order to validate the model, predictions are compared with experimental results of water-flooding test. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailInternational forum. Use of umbilical cord blood progenitor cells as an alternative for bone marrow transplantation.
Engelfriet, C. P.; Reesink, H. W.; Wagner, J. E. et al

in Vox Sanguinis (2002), 83(2), 172-87

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See detailPerspectives de dialogue entre des neuromédiateurs et les kératinocytes.
Pierard-Franchimont, Claudine ULg; Faska, N.; Nikkels, Arjen ULg et al

in Dermatologie Actualité (2002), 65

Les neuromédiateurs contrôlant l’activité de l’axe hypothalamo-hypophysaire sont aussi exprimés dans la peau. D’autres neuromédiateurs liés au stress le sont également. En fait, près d’une vingtaine de ... [more ▼]

Les neuromédiateurs contrôlant l’activité de l’axe hypothalamo-hypophysaire sont aussi exprimés dans la peau. D’autres neuromédiateurs liés au stress le sont également. En fait, près d’une vingtaine de ces molécules sont synthétisées in situ et sont connues pour avoir des récepteurs spécifiques et exprimer une activité biologique dans cet organe. Certaines exercent un impact fonctionnel sur les kératinocytes. Il s’agit en fait de systèmes paracrines neuro-kératinocytaires et autocrines par lesquels les kératinocytes expriment de nombreux récepteurs pour les neuromédiateurs qu’ils libèrent eux-mêmes. [less ▲]

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See detailLe changement de sexe : perspectives pronostiques
Michel, Aude; Mormont, Christian ULg

in Neuropsy News (2002), 1(5), 224-231

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See detailApplication of RAP-PCR and cDNA-AFLP to isolate genes of Candida oleophila (strain O) induced by the presence of galacturonic acid.
Massart, Sébastien ULg; Sens-Espel, Roser; Lepoivre, Philippe ULg et al

in Bulletin OILB/SROP = IOBC/WPRS Bulletin (2002), 25(10), 399-402

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See detailImpact of closed habitat on the entomological diversity and abundance in carrot open fields
Colignon, Pierre; Gaspar, Charles; Haubruge, Eric ULg et al

in Med. Fac. Landbouw. Univ. Gent (2002), 67(3), 481-486

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See detailInsecticide resistance enhances male reproductive success in a beetle
Arnaud, Ludovic; Haubruge, Eric ULg

in Evolution (2002), 56(12), 2435-2444

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See detailNew trends in dual 5-LOX/COX inhibition
De Leval, X.; Julémont, F.; Delarge, J. et al

in Current Medicinal Chemistry (2002), 9

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See detailErythropoiesis after nonmyeloablative stem-cell transplantation is not impaired by inadequate erythropoietin production as observed after conventional allogeneic transplantation.
Baron, Frédéric ULg; Fillet, Georges ULg; Beguin, Yves ULg

in Transplantation (2002), 74(12), 1692-6

BACKGROUND: It is now well established that after conventional allogeneic hematopoietic stem-cell transplantation (HSCT), erythropoietic recovery is impaired because erythropoietin (Epo) production ... [more ▼]

BACKGROUND: It is now well established that after conventional allogeneic hematopoietic stem-cell transplantation (HSCT), erythropoietic recovery is impaired because erythropoietin (Epo) production remains inadequate for prolonged periods of time. However, erythropoietic reconstitution after nonmyeloablative SCT (NMSCT) has never been characterized. METHODS: Twelve patients received a nonmyeloablative conditioning regimen consisting of 2 Gy total body irradiation (TBI) alone (n=6), 2 Gy TBI and fludarabine (n=3), or cyclophosphamide and fludarabine (n=3), followed by transplantation of allogeneic peripheral blood stem cells. Graft-versus-host-disease (GvHD) prophylaxis was carried out with mycophenolate mofetil (from day -1 to day 28) plus cyclosporine (from day -1 to day 120 or longer in case of chronic GvHD). Erythropoiesis was quantitated by soluble transferrin receptor (sTfR) levels, and the adequacy of Epo production was evaluated by the observed-to-predicted Epo ratio (O/P Epo). RESULTS: Mean sTfR levels decreased following the conditioning regimen but remained well within the normal range throughout the posttransplant period. The O/P Epo ratio presented an initial surge quite similar to that observed after conventional conditioning. Thereafter, the O/P Epo ratio normalized rapidly, and Epo levels remained adequate during the whole observation period. CONCLUSION: Contrarily to what is observed after myeloablative transplant, Epo levels remained adequate after NMSCT, resulting in normal erythropoiesis. These results suggest that the administration of erythropoietin therapy (rHuEpo) could be less effective after NMSCT than after conventional allogeneic transplant. [less ▲]

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See detailL'image du mois. "Les joyaux de la couronne".
DUYSINX, Bernard ULg; Carpentier, M; NGUYEN DANG, Delphine ULg et al

in Revue Médicale de Liège (2002), 57(12), 753-4

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See detailRapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
Limbourg, Florian P; Huang, Zhihong; Plumier, Jean-Christophe ULg et al

in Journal of Clinical Investigation (2002), 110(11), 1729-38

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate ... [more ▼]

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate neuroprotection. High-dose corticosteroids (20 mg/kg intraperitoneally), given within 2 hours of transient cerebral ischemia, acutely increased endothelial nitric oxide synthase (eNOS) activity, augmented regional cerebral blood flow (CBF) by 40% to 50%, and reduced cerebral infarct size by 32%. These neuroprotective effects of corticosteroids were abolished by the GR antagonist RU486 and by inhibition of phosphatidylinositol 3-kinase (PI3K), and were absent in eNOS(-/-) mice. To determine the mechanism by which GR activated eNOS, we measured the effect of corticosteroids on PI3K and the protein kinase Akt. In a ligand-dependent manner, GR activated PI3K and Akt in vitro and in vivo caused NO-dependent vasodilation, which was blocked by cotreatment with RU486 or the PI3K inhibitor LY294002 but not by transcriptional inhibitors. Indeed, a mutant GR, which cannot dimerize and bind to DNA, still activated PI3K and Akt in response to corticosteroids. These findings indicate that non-nuclear GR rapidly activates eNOS through the PI3K/Akt pathway and suggest that this mechanism mediates the acute neuroprotective effects of corticosteroids through augmentation of CBF. [less ▲]

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See detailLe refinancement des communautés et l’extension de l’autonomie fiscale des régions : aspects juridiques et économiques
Bourgeois, Marc ULg; Van Der Stichele, Géraldine; Verdonck, Magali

in Administration Publique [=AP] : Revue du Droit Public et des Sciences Administratives (2002)

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See detailMorphology, displacement and slip rates along the North Antolian Fault (Turkey)
Hubert, Aurelia ULg; Armijo, R.; Meyer, B. et al

in Journal of Geophysical Research (2002), 107(10.1029/2001JB000393),

Geological and geomorphological offsets at different scales are used to constrain the localization of deformation, total displacement, and slip rates over various timescales along the central and eastern ... [more ▼]

Geological and geomorphological offsets at different scales are used to constrain the localization of deformation, total displacement, and slip rates over various timescales along the central and eastern North Anatolian Fault (NAF) in Turkey. The NAF total displacement is reevaluated using large rivers valleys (80 ± 15 km) and structural markers (Pontide Suture, 85 ± 25 km; Tosya-Vezirko ̈pru ̈ basins, 80 ± 10 km). These suggest a Neogene slip rate of 6.5 mm/yr over 13 Myr. The river network morphology shows offsets at a range of scales (20 m to 14 km) across the main fault trace and is also used to estimate the degree to which deformation is localized. At a smaller scale the morphology associated with small rivers is offset by 200 m along the NAF. The age of these features can be correlated with the Holocene deglaciation and a slip rate of 18 ± 3.5 mm/yr is determined. This is consistent with a rate of 18 ± 5 mm/yr deduced independently from the 14C dating of stream terrace offsets. Over the short term, GPS data gives a similar rate of 22 ± 3 mm/yr. All our results tend to show that most of the deformation between the Anatolian and Eurasian lithospheric plates has been accommodated along, or very close to, the active trace of the NAF. The difference between the Neogene and the Holocene slip rate may be due to the recent establishment of the current plate geometry after the creation of the NAF. INDEX TERMS: 8107 Tectonophysics: Continental neotectonics; 8158 Tectonophysics: Plate motions—present and recent (3040); 7230 Seismology: Seismicity and seismotectonics; KEYWORDS: North Anatolian Fault, slip rate, total offset, strain localization [less ▲]

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See detailDélinquance et suicide? Un défi pour l'aide à la jeunesse
Malchair, Alain ULg

in Actes du 2ème Congrès international de la Francophonie et Prévention du suicide (2002)

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See detailEconomic evaluation of chronic hepatitis C treatment by interferon-ribavirin combination therapy in Belgium
Delwaide, Jean ULg

in Acta Gastro-Enterologica Belgica (2002), 65(4), 233-236

With present treatments for chronic hepatitis C by the combination of interferon alpha and ribavirin, it is possible to obtain a sustained viral response in a large number of patients. This viral response ... [more ▼]

With present treatments for chronic hepatitis C by the combination of interferon alpha and ribavirin, it is possible to obtain a sustained viral response in a large number of patients. This viral response is associated with long-term disappearance of the C virus, improvement of histology, improvement in quality of life and, most than likely, a reduction in the risk of premature death or infection-linked complications. This therapy is, however, expensive and the number of potentially treatable patients is high in view of the relatively high prevalence of the disease in the population. An economic evaluation is thus indispensable in order, on the one hand, to assess the cost-effectiveness ratio of the treatment (i.e. the extra cost to be paid for obtaining the greater effectiveness provided by the therapeutic combination in comparison with absence of treatment or treatment by interferon alone), and, on the other hand, to estimate practically the global cost of treatment for Belgium (i.e. the annual expense for society according to the number of patients treated per year). [less ▲]

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See detailRetrospective comparison of CD34-selected allogeneic peripheral blood stem cell transplantation followed by CD8-depleted donor lymphocyte infusions with unmanipulated bone marrow transplantation.
Baron, Frédéric ULg; Baudoux, Etienne ULg; Fillet, Georges ULg et al

in Hematology (2002), 7(3), 137-43

We have previously reported the feasibility of allogeneic CD34-selected PBSC transplantation followed by pre-emptive CD8-depleted DLI (study group). In this report, we retrospectively compare the clinical ... [more ▼]

We have previously reported the feasibility of allogeneic CD34-selected PBSC transplantation followed by pre-emptive CD8-depleted DLI (study group). In this report, we retrospectively compare the clinical outcome of the 24 patients included in this study with an historical group of 35 patients receiving unmanipulated marrow (BMT group). Patients in the study group had significantly faster neutrophil and platelet recovery and were discharged earlier than BMT patients. The actuarial 150-day (after DLI) probability of developing grade II-IV acute GVHD was 28% for the study group versus 62% for the BMT group (p=0.002). The actuarial 2-year probability of developing chronic GVHD was similar (37 versus 36% (NS)) but chronic GVHD was significantly delayed in the study group (p=0.003). The actuarial 2-year probability of relapse was 30% in the study group versus 33% in the BMT group (NS). The actuarial 2-year probability of survival was 45% in the study group versus 43% in the BMT group (NS). We conclude that allogeneic transplantation of CD34-selected PBSC followed by pre-emptive CD8-depleted DLI is feasible with rapid engraftment and minimizes the risk of severe GVHD. Large prospective trials are required to confirm these results. [less ▲]

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See detailApproches pharmacologiques de prévention du diabète de type 2.
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (2002), 60

L’augmentation rapide de la prévalence du diabète de type 2 impose la mise en place de stratégies de prévention. Outre les mesures hygiéno-diététiques, essentielles, diverses approches pharmacologiques ... [more ▼]

L’augmentation rapide de la prévalence du diabète de type 2 impose la mise en place de stratégies de prévention. Outre les mesures hygiéno-diététiques, essentielles, diverses approches pharmacologiques ont apporté récemment la preuve d’une certaine efficacité chez les sujets à risque de par la présence d’un excès pondéral et/ou d’une diminution de la tolérance au glucose. C’est le cas de plusieurs antidiabétiques oraux comme la metformine, l’acarbose ou encore la troglitazone. C’est également le cas de médicaments anti-obésité comme l’orlistat et, peut-être aussi, la sibutramine. L’inhibition du système rénine-angiotensine par un inhibiteur de l’enzyme de conversion ou par un antagoniste sélectif des récepteurs AT1 peut aussi, outre protéger contre les complications cardiovasculaires, prévenir l’apparition d’un diabète de type 2. Enfin, le rôle des médicaments hypolipidémiants reste controversé. De nouvelles études prospectives sont en cours pour confirmer ces résultats. [less ▲]

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See detailRelationship between markers of blood oxidant status and physiological variables in healthy and heaves-affected horses after exercise
Kirschvink, Nathalie; Art, Tatiana ULg; de Moffarts, Brieuc et al

in Equine Veterinary Journal. Supplement (2002), 34

Exercise-induced oxidative stress is investigated as a potential performance-limiting factor in human sports medicine. Therefore, the present study aimed to assess whether physiological variables that ... [more ▼]

Exercise-induced oxidative stress is investigated as a potential performance-limiting factor in human sports medicine. Therefore, the present study aimed to assess whether physiological variables that change with exercise intensity were correlated with blood oxidant markers in healthy and heaves-affected horses. Seven healthy horses, 8 heaves-affected in remission and 7 heaves-affected in crisis performed a standardised exercise test (SET) of stepwise increasing intensity. Variables monitored during exercise were heart rate (HR), venous plasma lactate (LA), packed cell volume (PCV) and arterial oxygen tension (PaO2). Oxidant markers (uric acid [UA], 8-iso-PGF2alpha and reduced [GSH] and oxidised glutathione [GSSG]) were analysed in venous peripheral blood sampled at rest (R), at peak-exercise intensity (Emax), 15 (E15) and 60 (E60) min after SET. There was a significant effect of heaves on oxidant markers and, therefore, correlation analyses between physiological variables and oxidant markers were performed separately per horse group. In healthy horses, UA analysed at Emax was positively correlated with LA. Furthermore, GSH analysed at Emax and E15 was positively correlated with PaO2. In healthy and heaves-affected horses in remission, GSH and GSSG determined at Emax were negatively correlated with HR. There was no significant correlation between 8-iso-PGF2alpha and physiological variables. In conclusion, a correlation between the physiological response to exercise and some oxidant markers exists in healthy horses. However, in heaves-affected horses the blood oxidant status is probably more dependant on airway disease than on exercise. Future studies should be undertaken to assess whether antioxidant supplementation might positively influence the oxidant-antiodidant balance in exercising horses. [less ▲]

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See detailLes antagonistes calciques ont-ils une place de première ligne dans le traitement de l'hypertension artérielle?
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2002), 57(2), 79-84

During the nineties, a controversy was noted in the literature about the potential risk of using calcium antagonists in the treatment of hypertension. Several recent studies, such as the INSIGHT’s one ... [more ▼]

During the nineties, a controversy was noted in the literature about the potential risk of using calcium antagonists in the treatment of hypertension. Several recent studies, such as the INSIGHT’s one have not confirmed this provided that one uses long-acting molecule. But the real beneficial effect due to the different antihypertensive classes is mainly linked to the magnitude of the blood pressure lowering effect. [less ▲]

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See detailChanging pattern of bacterial susceptibility to antibiotics in hematopoietic stem cell transplant recipients.
Frere, Pascale ULg; Hermanne, J.-P.; Debouge, M.-H. et al

in Bone Marrow Transplantation (2002), 29(7), 589-94

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to ... [more ▼]

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to antibiotics in 492 patients (198 allografts and 294 autografts) transplanted between 1982 and 1999 and evaluated whether ciprofloxacin prophylaxis and an empirical antibiotic regimen (glycopeptide + third-generation cephalosporin) were still valid. We collected all susceptibility tests performed during the initial hospitalization on blood cultures as well as routine surveillance cultures and analyzed susceptibility to ciprofloxacin and to major antibiotics used in our unit. Gram-positive cocci rapidly became resistant to ciprofloxacin (susceptibility around 70% in 1990 to less than 20% in 1998) but sensitivity to glycopeptides remained unaltered. There was a rapid decline in the number of patients colonized with Gram-negative bacilli in the early years of ciprofloxacin prophylaxis. However, susceptibility to ciprofloxacin fell sharply from around 90% in 1990 to around 30% in 1999. In parallel, susceptibility to ceftazidime also decreased to less than 80% in recent years. Piperacillin (+/- tazobactam) did not show any variation over time and its efficacy remained too low (about 60%). Imipenem as well as recently introduced cefepim and meropenem showed stable and excellent profiles (>90% susceptibility). In conclusion: (1) quinolone prophylaxis has now lost most of its value; (2) the choice of a third-generation cephalosporin for empirical antibiotic therapy may no longer be the best because of the emergence of Gram-negative strains resistant to beta-lactamases, such as Enterobacter sp. More appropriate regimens of empirical antibiotic therapy in HSCT recipients may be based on the use of a carbapenem or fourth-generation cephalosporin. [less ▲]

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See detailOrigine du Solutréen: le rôle de l'Espagne
Otte, Marcel ULg; Noiret, Pierre ULg

in Zephyrus (2002), LV

The Solutrean "culture" of France should be separated in two clearly distinct elements. (1) The "Proto-Solutrean" and the "early" Solutrean are linked to the late phases of the Gravettian of the northern ... [more ▼]

The Solutrean "culture" of France should be separated in two clearly distinct elements. (1) The "Proto-Solutrean" and the "early" Solutrean are linked to the late phases of the Gravettian of the northern plains. (2) The "middle and late" Solutrean seem to have originated in Spain. A movement from North Africa, in the most arid phase, constitutes the most likely hypothesis to explain this expansion. [less ▲]

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See detailQu'est-ce que l'expérience corporelle des patientes souffrant d'anorexie mentale ? Une étude empirique
Mayers, I.; Bragard, Isabelle ULg; Demoulin, Catherine et al

in Revue Francophone de Clinique Comportementale et Cognitive (2002), 7(3), 5-13

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See detailMise au point d'un modèle cartographique pour la description des stations forestières en Ardenne belge.
Claessens, Hugues ULg; Lejeune, Philippe ULg; Cuvelier, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(4), 209-220

The paper presents an original method dealing with the forest site types delineation. The suggested method consists in integrating a typological key in a GIS aiming at producing a thematic map that ... [more ▼]

The paper presents an original method dealing with the forest site types delineation. The suggested method consists in integrating a typological key in a GIS aiming at producing a thematic map that describes forest site types. Data used are the soil map of Belgium (digitized at the scale 1:20,000) and a digital elevation model built from a topographic map (scale 1:10,000). The typological key is mainly based on the methodology used by Thill et al. (1988) in the site types system for central Ardenne, the potential vegetation map of Sougnez and Dethioux (1975) and the ecoregion map of Delvaux and Galoux (1962). In that respect, site types are closely linked to the soil map and the phytosociological classification. So, they can be connected to the afforestation guide and different phytosociological and autecological studies concerning forest species. It is then possible to map the potential habitats or the site potentialities related to tree species. The key is valid for the Ardenne ecoregion located in Southern Belgium (elevation higher than 300 m). It has to be validated through an intensive use in the field, taking into account its imprecision linked to the types of collected data, chieffly those being digitized. The integration of such a tool in a SIG can be considered as an original way in terms of integrated forest management or forest sites description in the context of the project “Natura 2000” launched by the European Union. The study has been carried out within the framework of an experimental integrated management project concerning the Saint-Hubert forest (17,000 ha). [less ▲]

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See detailNonmyeloablative allogeneic hematopoietic stem cell transplantation.
Baron, Frédéric ULg; Beguin, Yves ULg

in Journal of Hematotherapy & Stem Cell Research (2002), 11(2), 243-63

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols (nonmyeloablative stem cell transplantation or NMSCT) based on a two-step approach: first, the use of immunosuppressive (but nonmyeloablative) preparative regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. Preliminary results showed that NMSCT were feasible with a relatively low transplant-related mortality (TRM), even in patients older than 65 years. In addition, strong antitumor responses were observed in several hematological malignancies as well as in some patients with renal cell carcinoma. After discussing the mechanisms and efficacy of the GVL effect as well as the rationale for NMSCT strategies, this article reviews the first results of ongoing clinical trials. Innovative modalities that may permit amplification of the GVL effect while minimizing the risk of GVHD are discussed. Because the benefits of NMSCT over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

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See detailEffect of some insecticides on acetylcholinesterase from beneficial insects: Coccinella septempunctata, Chrysoperla carnea and Forficula auricularia
Boszic, Andras; Francis, Frédéric ULg; Gaspar, Charles et al

in Med. Fac. Landbouw. Univ. Gent (2002), 67(3), 671-677

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See detailLa clé des champs au risque de mettre la clé sous la porte
Graas, Christelle; Noel, Véronique; argento, gino et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2002), 5

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See detailA Set Of Primers For Amplification Of Mitochondrial Dna In Picea Abies And Other Conifer Species
Jeandroz, S.; Bastien, D.; Chandelier, A. et al

in Molecular Ecology Notes (2002), 2(4),

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See detailA set of primers for amplification of mitochondrial DNA in Picea abies and other conifer species.
Jeandroz, S.; Bastien, D.; Chandelier, A. et al

in Molecular Ecology Notes (2002), 2

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See detailUse of X-ray microtomography to follow the convective heat drying of wastewater sludges
Léonard, Angélique ULg; Blacher, Silvia ULg; Marchot, Pierre ULg et al

in Drying Technology (2002), 20(4-5), 1053-1069

X-ray microtomography is proposed as a new tool to investigate the evolution of size, shape and texture of soft materials during a drying operation. This study is focused on the drying of mechanically ... [more ▼]

X-ray microtomography is proposed as a new tool to investigate the evolution of size, shape and texture of soft materials during a drying operation. This study is focused on the drying of mechanically dewatered sludges from a secondary wastewater treatment. The shrinkage phenomenon is shown to play a crucial role in the control of the drying process. The shrinkage curves are determined by analysing the shape and size of cross sectional microtomographic images of sludge extrudates at different levels of drying. The observation of drying and shrinkage curves allows us to determine 3 critical water content values, which define different drying zones where extragranular, intragranular or mixed limitations prevail. When drying is externally controlled. the decrease of the drying rate observed during experiments can be related to the reduction of the external area of the sample, i.e., to shrinkage. When drying is internally controlled, resistances inside the solid govern the process. Between these two extreme situations, the drying rate reduction is the result of both the external area decrease and the development of internal resistances limiting drying. A multizone model is proposed to describe quantitatively these observations. The analysis of the internal texture of the Sludge extrudates reveal, crack formation at the end of the drying process. The onset of crack formation is clearly related to the appearance of internal transfer limitations. i.e., humidity and temperature gradients inside the material. [less ▲]

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See detailLa libre circulation des personnes dans l'Union européenne (1er janvier - 31 décembre 2001)
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2002), 10(3), 65

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See detailNew 3-deoxyanthocyanidins from leaves of Arrabidaea chica
Devia, B.; Llabres, Gabriel ULg; Wouters, J. et al

in Phytochemical Analysis (2002), 13(2, Mar-Apr), 114-120

Two new 3-deoxyanthocyanidins, 6,7,3',4'-tetrahydroxy-5-methoxyflavylium and 6,7,4'-trihydroxy-5-methoxyflavylium, and the pigment carajurin, which has been previously identified, were isolated from dried ... [more ▼]

Two new 3-deoxyanthocyanidins, 6,7,3',4'-tetrahydroxy-5-methoxyflavylium and 6,7,4'-trihydroxy-5-methoxyflavylium, and the pigment carajurin, which has been previously identified, were isolated from dried leaves of Arrabidaea chica, a creeper native to the American tropics. The structures of the components were elucidated by H-1- and C-13-NMR spectroscopy and HPLC-MS, including X-ray crystallographic analysis for carajurin. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailLes sans-papiers en Belgique
Martiniello, Marco ULg; Rea, Andrea

in Hommes & Migrations (2002), 1238

Qui sont ces “exclus de l’intérieur”, ces “sans-droits”, générés par une Belgique dont la politique d’immigration s’adapte mal aux nouveaux migrants ? Une étude, menée auprès de cent trente sans-papiers ... [more ▼]

Qui sont ces “exclus de l’intérieur”, ces “sans-droits”, générés par une Belgique dont la politique d’immigration s’adapte mal aux nouveaux migrants ? Une étude, menée auprès de cent trente sans-papiers et clandestins, rend compte de la précarité de leurs conditions de vie. L’analyse des données recueillies permet de dresser un portrait sociologique précis de cette population, et d’examiner à la loupe la misère des conditions de départ, la clandestinité, le travail au noir. Les auteurs de l’étude expliquent, notamment, pourquoi certains sans-papiers n’ont pas cherché à régulariser leur situation, malgré la vaste campagne lancée par les pouvoirs publics en 2000. [less ▲]

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See detailLes-Bons-Villers, l'église Saint-Martin à Mellet
Hoffsummer, Patrick ULg

in Bulletin de la Fondation Vanhove-Vonneche (2002), 4

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See detailCharacterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium.
Aendekerk, Severine; Ghysels, Bart ULg; Cornelis, Pierre et al

in Microbiology (Reading, England) (2002), 148(Pt 8), 2371-81

Vanadium has an antibacterial activity against Pseudomonas aeruginosa, especially under conditions of iron limitation. Some degree of resistance to V is inducible by prior exposure to the metal. One ... [more ▼]

Vanadium has an antibacterial activity against Pseudomonas aeruginosa, especially under conditions of iron limitation. Some degree of resistance to V is inducible by prior exposure to the metal. One mutant (VS1) with a higher sensitivity to V was obtained by transposon mutagenesis of P. aeruginosa PA 59.20, a clinical isolate. This mutant had an insertion in a non-coding region, upstream of a cluster of four genes. Three of them show similarities to genes corresponding to known P. aeruginosa antibiotic efflux systems, including an efflux protein, a membrane fusion protein and an outer-membrane porin. This cluster was named mexGHI-opmD. By allelic exchange, three mutants, ncr (for non-coding region), mexI and opmD were constructed in P. aeruginosa PAO1. Next to V sensitivity, the ncr, mexI and opmD mutants also showed reduced production of elastase, rhamnolipids, pyocyanine, pyoverdine and had reduced swarming motility, phenotypes that are known to be regulated by quorum sensing. All wild-type phenotypes, including growth in the presence of V, were restored by complementation with the complete cluster. The production of N-acyl-homoserine lactones (AHLs) was detected using the Chromobacter violaceum bioassay. Total extracts from the three mutants failed to induce the production of violacein by C. violaceum, although AHLs were detected by TLC and C. violaceum overlay. Violacein production was restored by complementation with mexGHI-opmD. The opmD mutant grew very slowly in LB or CAA medium, indicating that OpmD has an important physiological function for the cell. In conclusion, it is believed that the MexGHI-OpmD pump is probably involved in AHL homeostasis in P. aeruginosa. [less ▲]

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See detailTransient behaviour of water ages in the World Ocean
Deleersnijder, Eric; Mouchet, Anne ULg; Delhez, Eric ULg et al

in Mathematical & Computer Modelling (2002), 36(1-2), 121-127

The transient behaviour of the age of the water and that of the surface water is studied in the World Ocean. At any time and position, the age of the water, the age and the concentration of the surface ... [more ▼]

The transient behaviour of the age of the water and that of the surface water is studied in the World Ocean. At any time and position, the age of the water, the age and the concentration of the surface water are seen to obey a simple algebraic relation. The latter is illustrated by means of results of a three-dimensional World Ocean model and the analytical solution of an idealised, purely-diffusive, one-dimensional problem. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailTexture characterization of ultramacroporous materials using non-destructive methods
Blacher, Silvia ULg; Maquet, Véronique; Léonard, Angélique ULg et al

in Studies in Surface Science and Catalysis (2002), 158

Image analysis, impedance spectroscopy and X-ray microtomography have been used as non-destructive methods in order to characterize ultramacroporous materials (pore width > 1 mum). These methods are used ... [more ▼]

Image analysis, impedance spectroscopy and X-ray microtomography have been used as non-destructive methods in order to characterize ultramacroporous materials (pore width > 1 mum). These methods are used to investigate the texture of different kinds of materials, i.e., highly oriented polylactide (PLA) foams prepared by freeze-drying, isotropic polyolefin foams prepared by thermal degradation of a chemical foaming agent and convective heat dried wastewater sludges. The image analysis of SEM micrographs recorded at different magnifications gave information on the pore size distribution and pore morphology. Impedance spectroscopy was used to investigate the transport properties of the three-dimensional porous matrices by measurement of the water ionic conduction. Finally, 3D image reconstruction from 2D cross-sections obtained by X-ray microtomography allowed visualizing the pore structure. [less ▲]

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See detailA mathematical comment on the formulae for the aggregation index and the shape index.
Bogaert, Jan ULg; Myneni, R B; Knyazikhin, Y

in Landscape Ecology (2002), 17(1), 87-90

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See detailBiocontrol Of Listeria Monocytogenes In A Model Cultured Milk (Lben) By In Situ Bacteriocin Production From Lactococcus Lactis Ssp Lactis
Benkerroum, N.; Ghouati, Y.; Ghalfi, H. et al

in International Journal of Dairy Technology (2002), 55(3),

Bacteriocin-producing (Bac+) Lactococcus lactis ssp. lactis CCMM/IAV/BK1 isolated from traditional lben was used in the preparation of lben from pasteurized milk to assess its potential inhibitory ... [more ▼]

Bacteriocin-producing (Bac+) Lactococcus lactis ssp. lactis CCMM/IAV/BK1 isolated from traditional lben was used in the preparation of lben from pasteurized milk to assess its potential inhibitory activity against Listeria monocytogenes ATCC 7644. Production of bacteriocin (arbitrary units, AU) in MRS broth fortified with yeast extract (MRSY) in a fermentor under controlled and uncontrolled pH conditions was also investigated. This Bac+ strain yielded about 35 times more bacteriocin when the pH was maintained constant at 6.5 than under varying pH conditions. To test the effect of in situ bacteriocin production against L. monocytogenes, lben was made from cow's milk artificially contaminated with approximately 107 cfu/mL and fermented with a mixed mesophilic starter culture consisting of the lactococcal Bac+ organism and Lc. lactis ssp. lactis biovar diacetylactis 66, a diacetyl-producing strain, in a ratio of 1 : 1. Numbers of L. monocytogenes were monitored during fermentation and storage of lben at refrigeration temperature (c. 7°C) for up to 6 days. Performances of the Bac+ starter were compared to those of an isogenic Bac- derivative strain obtained from the Bac+ starter by curing with ethidium bromide. The results showed that the amount of L. monocytogenes decreased to below the detectable level in a 1-mL sample within 24 h of storage at 7°C in lben fermented with the Bac+ starter culture. On the contrary, L. monocytogenes survived for 6 days of storage at 7°C in lben made with the Bac- starter. The Bac+ wild strain of the starter studied could be adequately used to produce lben or similar indigenous fermented milks of improved hygienic quality on an industrial scale. Alternatively, it could be used as an adjunct in minimally processed products or in products obtained from raw milk to add a safety factor. [less ▲]

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See detailEffects of lesions of nucleus taeniae on appetitive and consummatory aspects of male sexual behavior in Japanese quail
Absil, Philippe ULg; Braquenier, Jean-Baptiste ULg; Balthazart, Jacques ULg et al

in Brain, Behavior & Evolution (2002), 60(1), 13-35

Neurochemical, hodological and functional criteria suggest that the nucleus taeniae and parts of the adjacent archistriatum represent the avian homologue of parts of the mammalian amygdaloid complex. It ... [more ▼]

Neurochemical, hodological and functional criteria suggest that the nucleus taeniae and parts of the adjacent archistriatum represent the avian homologue of parts of the mammalian amygdaloid complex. It has been proposed in particular that the nucleus taeniae is the homologue of the mammalian medial amygdala. In male quail, relatively large lesions to the posterior/medial archistriatum selectively decrease the expression of appetitive sexual behavior in a manner reminiscent of similar manipulations involving the medial amygdala in mammals. We investigated the effects of discrete lesions restricted to nucleus taeniae and of lesions to an adjacent part of the archistriaturn (pars intermedium ventralis, Alv) on the expression of appetitive (ASB) and consummatory (CSB) aspects of male sexual behavior. ASB was measured by a learned social proximity response (after copulation a male quail stands in front of a window providing visual access to a female) and by the frequency of rhythmic cloacal sphincter movements. CSB was assessed by the frequency of mount attempts (MA) and cloacal contact movements (CCM). Lesions confined to nucleus taeniae and to Alv did not influence the acquisition or the maintenance of the two responses indicative of ASB. In contrast, lesions of nucleus taeniae significantly increased the occurrence frequencies of MA and CCM when administered before the beginning of behavior testing and increased the frequency of MA only when performed on sexually experienced subjects. No effect of Alv lesions could be detected. The discrepancy between these results and previous experiments in quail might reflect procedural differences, but more probably differences in locations of the lesions that were restricted in the current study to the anterior part of taeniae. Those in the Thompson study were in the posterior part of this nucleus. These findings indicate that there is a larger degree of functional heterogeneity in the nucleus taeniae than previously thought. The effects of taeniae lesions suggest that this nucleus, similar to the medial amygdala in mammals, might be implicated in the control of sexual satiety. Copyright (C) 2002 S. Karger AG, Basel. [less ▲]

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See detailLa mesure de la pression artérielle : écueils et chausse-trapes
Rorive, Georges ULg; Dubois, Bernard ULg; Saint-Remy, Annie ULg

in Revue Médicale de Liège (2002), 57(5), 250-252

La mesure de la pression artérielle est probablement l'acte médical le plus souvent réalisé et certainement un des moins fiables. L'introduction de la mesure ambulatoire de la pression artérielle a permis ... [more ▼]

La mesure de la pression artérielle est probablement l'acte médical le plus souvent réalisé et certainement un des moins fiables. L'introduction de la mesure ambulatoire de la pression artérielle a permis d'identifier l'importance de l'effet consultatio et, par là, de définir l'hypertension de "la blouse blanche". Celle-ci se définit comme une pression artérielle pathologique à la consultation et strictement normale en dehors. Si on la définit de cette manière, cette pathologie ne s'accompagne pas d'une augmentation de la fréqunce des affections cardiovasculaires. Chez un tiers des patients, cependant, elle évolue vers des formes plus sévères de l'hypertension. [less ▲]

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See detailHsp27 in the nervous system: expression in pathophysiology and in the aging brain.
Krueger-Naug, A. M. R.; Plumier, Jean-Christophe ULg; Hopkins, D. A. et al

in Progress in Molecular and Subcellular Biology (2002), 28

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See detailBelgian peer review experience on the Achille's heel in haemodialysis care: vascular access
Theelen, Bernadette ULg; Rorive, Georges ULg; Krzesinski, Jean-Marie ULg et al

in EDTNA/ERCA Journal (2002), 28(4, Oct-Dec), 164-166

AIMS: In order to improve the supervision and to evaluate the quality of care in dialysis units, a national project was promoted as a Peer Review. It consisted of systematic, continuous and critical ... [more ▼]

AIMS: In order to improve the supervision and to evaluate the quality of care in dialysis units, a national project was promoted as a Peer Review. It consisted of systematic, continuous and critical evaluation of the care and the application of international guidelines and compared the reality of care with standards. METHOD: The first chart consisted of the evaluation of infectious episodes of vascular access. This point is particularly relevant since infection represents the second cause of mortality in haemodialysis. A questionnaire concerning each patient was designed. Questions concerned the description of vascular access and the related infectious events. Each questionnaire included 21 items. The project involved 29 dialysis centres, 1,644 patients and 1,775 vascular accesses. The database included 90,525 data. RESULTS: Among the 29 centres, the native arteriovenous fistula (AVF) is the first choice (67.5%) in vascular access, but the proportion of AVF decreases with age contrary to the catheter, which is more frequently chosen, in older patients. Independent of age, 20% of hospitalisations are among patients with catheters and only 7% among patients with AVF. The RR (relative risk) of being hospitalised (any complication of vascular access) is 1.68 for patients with catheters compared to patients with AVF. The rate of infections does not increase with age but is higher for patients with catheters (RR = 2.26). The number of infections appears to be dependent on the staphylococcus aureus carriage in the year. CONCLUSIONS: This first step allows each centre to compare itself to others in an anonymous way. This approach should lead to specific recommendations to improve the quality of care in dialysis units. [less ▲]

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See detailOn the specificity of cyclodextrin complexes detected by electrospray mass spectrometry
Gabelica, Valérie ULg; Galic, Nives; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2002), 13(8), 946-953

alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant ... [more ▼]

alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant that increases with the diacid chain length. However, the electrospray mass spectrometry (ES-MS) spectra showed that the relative intensity of the complex did not vary significantly with chain length. This contradiction is caused by a contribution of nonspecific adducts to the signal of the complex in ES-MS. In order to estimate the contribution of nonspecific adducts to the total intensity of the complexes with alpha-cyclodextrin, the comparison was made between alpha-cyclodextrin and maltohexaose, the latter being incapable of making inclusion complexes in solution. The signal observed for complexes between diacids and maltohexaose can only result from nonspecific electrostatic aggregation, and is found to be more favorable with the shorter diacids. This is also supported by MS/MS experiments. A procedure is described which allows estimation of the contribution of the nonspecific complex in the spectra of the complexes with alpha-cyclodextrin by using the relative intensity of the complex with maltohexaose. The contribution of the specific complex to the total signal intensity is found to increase with the diacid chain length, which is in agreement with solution behavior. [less ▲]

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See detailComment je traite.... Un pityriasis rubra pilaire.
Fraiture, A. L.; Braham, C.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(6), 363-5

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical ... [more ▼]

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical calcipotriol may improve the clinical presentation. [less ▲]

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See detailShort- and long-term advantages of an alternative ontogenetic pathway
Denoël, Mathieu ULg; Hervant, F.; Schabetsberger, R. et al

in Biological Journal of the Linnean Society (2002), 77(1), 105-112

We documented hypotheses on the evolution of developmental heterochronies by estimating short- and long-term advantages of alternative morphs. In this respect, we compared food energy intakes and body ... [more ▼]

We documented hypotheses on the evolution of developmental heterochronies by estimating short- and long-term advantages of alternative morphs. In this respect, we compared food energy intakes and body condition between paedomorphic and metamorphic Alpine newts (Triturus alpestris, Caudata, Amphibia) in four populations. Because we found a strong correlation between fat reserves and body condition, we used this last parameter as an indicator of long-term gains. In all studied sites, paedomorphic females showed higher body condition than metamorphic ones. Paedomorphic males were also at advantage in two populations. Paedomorphs exhibited higher energy intakes than metamorphs in two populations and similar gains in two others. Our results support unifying theories that predict the occurrence of facultative paedomorphosis in varied habitats as paedomorphs exhibited better energy balance than metamorphs. This work shows the need for considering integrative parameters such as body condition in the comparative study of performances when studying developmental heterochronies. (C) 2002 The Linnean Society of London, Biological Journal of the Linnean Society, 2002, 77, 105-112. [less ▲]

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See detailThe role of the somatotropic axis in the mammalian metabolism
Renaville, Robert ULg; Parmentier, Isabelle; Haezebroeck, Valérie et al

in Acta Anatomica. Supplementum (2002), 5

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See detailPathologie cutanée non infectieuse du pied chez le sportif.
Bourguignon, Raphaël; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2002), 72

En dehors du problème des mycoses cutanées, la peau et les ongles des pieds des sportifs sont le siège de diverses maladies bénignes mais qui peuvent cependant s’avérer invalidantes. Les disciplines de ... [more ▼]

En dehors du problème des mycoses cutanées, la peau et les ongles des pieds des sportifs sont le siège de diverses maladies bénignes mais qui peuvent cependant s’avérer invalidantes. Les disciplines de l’athlétisme et quelques autres sports en sont le plus souvent responsables car les microtraumatismes sont fréquemment impliqués. L’identification précise des désordres cutanés aide à prendre les mesures adéquates pour leur prévention. Les traitements sont essentiellement non-invasifs. [less ▲]

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See detailL'image du mois. Sclérose tubéreuse de Bourneville.
Garcia, Roy; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(7), 425-7

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See detailIce-dynamic conditions of Shirase Glacier, Antarctica, inferred from ERS SAR interferometry
Pattyn, Frank; De Rauw, Dominique ULg

in Journal of Glaciology (2002), 48(163), 559-565

The surface velocity field of Shirase Glacier, a fast-flowing East Antarctic outlet glacier, is determined from ERS synthetic aperture radar (SAR) images by means of speckle tracking using phase ... [more ▼]

The surface velocity field of Shirase Glacier, a fast-flowing East Antarctic outlet glacier, is determined from ERS synthetic aperture radar (SAR) images by means of speckle tracking using phase correlation, a technique which matches small image kernels of two complex SAR images by maximization of the local coherence. Velocity estimates are used to calculate surface strain rates, which are then used to calculate the large-scale, vertically integrated force balance and to determine the major stress components resisting the driving stress. For the whole glacier system, the driving stress is largely balanced by the basal drag, but with contributions from lateral drag up to 15% of the driving stress at the grounding line. Longitudinal stress gradients have only local importance to the balance of forces, limited to an area of a few square kilometers near the grounding line, where they resist the driving stress. In the grounded part of the glacier, >90% of the total ice velocity is due to basal sliding. Comparison with a balance-flux distribution of the Antarctic ice sheet suggests that the glacier in the downstream part of the Shirase drainage basin is close to equilibrium, showing a slight negative imbalance. [less ▲]

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See detailSelf-adapting time integration management in crash-worthiness and sheet metal forming computations
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in International Journal of Vehicle Design (2002), 30(1-2), 67-114

Variable step strategies are especially well suited to deal with problems characterized by high non-linearity and contact/impact, and resolved with an implicit scheme. Both phenomena are typical of ... [more ▼]

Variable step strategies are especially well suited to deal with problems characterized by high non-linearity and contact/impact, and resolved with an implicit scheme. Both phenomena are typical of dynamic simulations of contact-impact problems, as well as sheet metal forming. Constant step size strategies do not give a satisfactory answer for this kind of problem, since it is very difficult, if not impossible, for the user to find an appropriate time step that does not lead to divergence nor generate extremely costly computations. An automatic time stepping algorithm is proposed, which takes into account the recent history of accelerations in the deformable bodies under consideration. More precisely, the adaptation algorithm is based on estimators of the integration error of the differential dynamic balance equations. This allows for adaptation of the step size to capture correctly the transient phenomena, with characteristic times which can range from relatively long (after contact, or during sheet metal forming) to very short (during contact-impact). thus ensuring precision while keeping the computation cost to a minimum. Furthermore, we will see that this strategy can be used in explicit schemes. Additionally, the proposed algorithm automatically takes decisions regarding the necessity of updating the tangent matrix or stopping the iterations, further reducing the computational costs especially, when the Augmented Lagrangian method is used. As an illustration of the capabilities of this algorithm, several numerical simulations (shock absorber devices for vehicle crash-worthiness or sheet metal forming) problems will be presented. Other simulations pertaining to the sheet metal forming for vehicle structures will also be investigated, thus demonstrating the versatility, the capabilities and the efficiency of the proposed strategy. [less ▲]

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See detailResponses and adaptations of Episyrphus balteatus and Adalia bipunctata to allelochemicals from Brassicaceae plant through their preys
Vanhaelen, Nicolas; Haubruge, Eric ULg; Gaspar, Charles et al

in International Symposium on Ecology of Aphidophaga (2002)

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See detailThe complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription.
Gaudray, Gilles ULg; Gachon, Frederic; Basbous, Jihane et al

in Journal of virology (2002), 76(24), 12813-22

The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral ... [more ▼]

The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral protein encoded by the complementary strand of the HTLV-1 RNA genome. This protein, designated HBZ (for HTLV-1 bZIP factor), contains a N-terminal transcriptional activation domain and a leucine zipper motif in its C terminus. We show here that HBZ is able to interact with the bZIP transcription factor CREB-2 (also called ATF-4), known to activate the HTLV-1 transcription by recruiting the viral trans-activator Tax on the Tax-responsive elements (TxREs). However, we demonstrate that the HBZ/CREB-2 heterodimers are no more able to bind to the TxRE and cyclic AMP response element sites. Taking these findings together, the functional inactivation of CREB-2 by HBZ is suggested to contribute to regulation of the HTLV-1 transcription. Moreover, the characterization of a minus-strand gene protein encoded by HTLV-1 has never been reported until now. [less ▲]

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See detailOptimization of Yarrowia lipolytica's β-oxidation pathway for γ-decalactone production
Waché, Y.; Aguedo, Mario ULg; LeDall, M.-T. et al

in Journal of Molecular Catalysis B : Enzymatic (2002), 19-20

The yeast Yarrowia lipolytica growing on methyl ricinoleate produces various lactones, γ-decalactone, the worthy aroma compound, 3-hydroxy-γ-decalactone without sensorial properties and two decenolides of ... [more ▼]

The yeast Yarrowia lipolytica growing on methyl ricinoleate produces various lactones, γ-decalactone, the worthy aroma compound, 3-hydroxy-γ-decalactone without sensorial properties and two decenolides of various interest. Unfortunately, these three latter lactones are produced at high levels by this yeast, decreasing yields and complicating the extraction of γ-decalactone. In this study, the production of γ-decalactone was increased through a genetic engineering of the strain and the accumulation of the three other lactones was lowered. Theses results show that it is possible to improve the mastering of the complex β-oxidation pathway (the metabolic pathway involved in these bioconversions) by playing on genetic factors. © 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailExperimental Validation Of The Constant Level Method For Identification Of Non-Linear Multi-Degree-Of-Freedom Systems
Dimitriadis, Grigorios ULg

in Journal of Sound & Vibration (2002), 258(5), 829-845

System identification for non-linear dynamical systems could find use in many applications such as condition monitoring, finite element model validation and determination of stability. The effectiveness ... [more ▼]

System identification for non-linear dynamical systems could find use in many applications such as condition monitoring, finite element model validation and determination of stability. The effectiveness of existing non-linear system identification techniques is limited by various factors such as the complexity of the system under investigation and the type of non-linearities present. In this work, the constant level identification approach, which can identify multi-degree-of-freedom systems featuring any type of non-linear function, including discontinuous functions, is validated experimentally. The method is shown to identify accurately an experimental dynamical system featuring two types of stiffness non-linearity. The full equations of motion are also extracted accurately, even in the presence of a discontinuous non-linearity. [less ▲]

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See detailNew in situ generated ruthenium catalysts bearing N-heterocyclic carbene ligands for the ring-opening metathesis polymerization of cyclooctene
Delaude, Lionel ULg; Szypa, Magdalena; Demonceau, Albert ULg et al

in Advanced Synthesis & Catalysis (2002), 344(6-7), 749-756

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene ... [more ▼]

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene)](2) and potassium tert-butoxide or sodium hydride to generate the corresponding ruthenium-N-heterocyclic carbene complexes in situ. Catalyst precursors derived from imidazol(in)ium salts bearing the 2,4,6-trimethylphenyl (mesityl) and the 2,6-diisopropylphenyl groups were also prepared. The catalytic activity of all these species in the photoinduced ring-opening metathesis polymerization of cyclooctene was investigated. The C4-C5 double bond in the imidazole ring of the N-heterocyclic carbene ligands was not crucial to achieve high catalytic efficiencies. The presence or the absence of alkyl groups on the ortho positions of the phenyl rings had a more pronounced influence. Blocking all the ortho positions was a requisite for obtaining efficient catalysts. Failure to do so probably results in the ortho-metallation of the carbene ligand, thereby altering the coordination sphere of the ruthenium active centers. [less ▲]

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See detailPreemptive cellular immunotherapy after T-cell-depleted allogeneic hematopoietic stem cell transplantation.
Baron, Frédéric ULg; Beguin, Yves ULg

in Biology of Blood & Marrow Transplantation (2002), 8(7), 351-9

GVHD is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is due to donor lymphocytes that are cotransplanted with donor stem cells. These donor ... [more ▼]

GVHD is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is due to donor lymphocytes that are cotransplanted with donor stem cells. These donor lymphocytes are primed by histocompatibility differences between donors and recipients and activated by a cytokine storm caused by the conditioning regimen. The most efficient method for prevention of GVHD consists of T-cell depletion (TCD) of the graft. However, TCD usually leads to an increased risk of leukemia relapse because of the loss of the graft-versus-leukemia (GVL) effect. Several groups have studied the feasibility of preemptive donor lymphocyte infusion (DLI) to lessen the impact of TCD on leukemia relapse. Preemptive DLI is given several weeks to months after the transplantation, ie, after the cytokine storm and after the patient has recovered from conditioning-regimen-related toxicities. After briefly discussing various techniques of TCD of the graft and the efficacy of DLI, this article reviews the first clinical studies evaluating a strategy of TCD of the graft followed by preemptive DLI. [less ▲]

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See detailThe Euler number as an index of spatial integrity of landscapes: evaluation and proposed improvement.
Bogaert, Jan ULg; Van Hecke, P; Ceulemans, R

in Environmental Management (2002), 29(5), 673-682

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See detailDetermination Of The Methionine Requirement Of Finishing Double-Muscled Belgian Blue Bulls With A Three-Step Method
Froidmont, Eric; Beckers, Yves ULg; Thewis, André ULg

in Canadian Journal of Animal Science (2002), 82(1), 95-102

A three-step technique was used to determine total amino acids (AA) and the first limiting AA requirements in finishing double-muscled Belgian Blue (dmBB) bulls. In a first experiment, three dmBB bulls ... [more ▼]

A three-step technique was used to determine total amino acids (AA) and the first limiting AA requirements in finishing double-muscled Belgian Blue (dmBB) bulls. In a first experiment, three dmBB bulls (505 ± 21 kg) received a low metabolizable protein diet containing 25% meadow hay and 75% concentrate. Net energy supply was adequate for maximizing daily gains because of continuous infusion of dextrose into the duodenum. The intestinal apparent disappearance of essential AA (EAA) averaged 70.8% and was the lowest for histidine (61.3%) and the highest for arginine (79.9%). In a second experiment, four dmBB bulls (517 ± 16 kg) received the same diet supplemented with duodenal infusion of dextrose and four doses of Na-caseinate (17, 33, 50 and 66% of metabolizable dietary AA) in a 4 × 4 Latin square design. Nitrogen retention for the basal diet alone and the four increasing supplements of Na-caseinate averaged 61, 64, 74, 75 and 78 g d–1, respectively. A supply of 720 g d–1 of metabolizable AA was defined as optimising the N utilization for animal growth. Based on patterns of plasma concentrations, methionine and phenylalanine were probably the limiting AA. In a third experiment, five dmBB bulls (513 ± 60 kg) fed the basal diet received duodenal infusion of dextrose and AA, equivalent to the second dose in exp. 2 except for the supply of metabolizable methionine (12.8, 15.1, 17.6, 20.1, 22.6 and 25.1 g d–1) that varied in a 6 × 6 Latin square design with one missing animal. On the basis of N retention, the metabolizable methionine requirement was estimated to 22.8 g d–1 and corresponded to 360 mg of metabolizable methionine per gram of N retained. [less ▲]

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See detailA pulsating auroral X-ray hot spot on Jupiter
Gladstone, G. R.; Waite, J. H.; Grodent, Denis ULg et al

in Nature (2002), 415(6875), 1000-1003

Jupiter's X-ray aurora has been thought to be excited by energetic sulphur and oxygen ions precipitating from the inner magnetosphere into the planet's polar regions(1-3). Here we report high-spatial ... [more ▼]

Jupiter's X-ray aurora has been thought to be excited by energetic sulphur and oxygen ions precipitating from the inner magnetosphere into the planet's polar regions(1-3). Here we report high-spatial-resolution observations that demonstrate that most of Jupiter's northern auroral X-rays come from a 'hot spot' located significantly poleward of the latitudes connected to the inner magnetosphere. The hot spot seems to be fixed in magnetic latitude and longitude and occurs in a region where anomalous infrared(4-7) and ultraviolet(8) emissions have also been observed. We infer from the data that the particles that excite the aurora originate in the outer magnetosphere. The hot spot X-rays pulsate with an approximately 45-min period, a period similar to that reported for high-latitude radio and energetic electron bursts observed by near-Jupiter spacecraft(9,10). These results invalidate the idea that jovian auroral X-ray emissions are mainly excited by steady precipitation of energetic heavy ions from the inner magnetosphere. Instead, the X-rays seem to result from currently unexplained processes in the outer magnetosphere that produce highly localized and highly variable emissions over an extremely wide range of wavelengths. [less ▲]

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See detailInteraction of odorous lactones with phospholipids: Implications in toxicity towards producing yeast cells
Aguedo, Mario ULg; Beney, L.; Waché, Y. et al

in Biotechnology Letters (2002), 24(23), 1975-1979

Some lactonic aroma compounds, that can be produced industrially by microorganisms, become toxic towards the producing cells as these compounds reach high concentrations in the culture medium. To ... [more ▼]

Some lactonic aroma compounds, that can be produced industrially by microorganisms, become toxic towards the producing cells as these compounds reach high concentrations in the culture medium. To determine the manner by which these metabolites may influence yeast physiology, the effects of four lactones (concentration range of 100 to 300 mg l-1) on the growth of Yarrowia lipolytica and on the phase behaviour of deuterated dimyristoylphos-phatidylcholine (DMPC-d27) were studied. The results showed that the hydrophobic lactones decrease the phase transition temperature (Tm) of DMPC-d27 bilayers and that Tm decrease (ΔTm) was related to the inhibitory action of the lactones on yeast growth (evaluated by the lag time). These results suggest that whatever the lactone, a ΔTm of at least 2.5°C resulted in a total growth inhibition: this implicates the lactone-phospholipids interaction in the mechanism of yeast growth inhibition. The test used in the present study may be a predicting method to assess the in vivo action of potential membrane active compounds. [less ▲]

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See detailPre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.
Baron, Frédéric ULg; Siquet, Jean; Schaaf-Lafontaine, Nicole ULg et al

in Haematologica (2002), 87(1), 78-88

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood ... [more ▼]

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood stem cell (PBSC) transplantation followed by CD8-depleted donor lymphocyte infusion (DLI). DESIGN AND METHODS: Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2 x 10(6), 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 14-24). The 1st aliquot was infused on day 60 and the other 1 (2) cryopreserved and infused on days 100 (and 140). RESULTS: An average of 100%, 100% and 84% of the scheduled dose could be administered in DLI 1, 2 and 3, respectively. Although the study group was at very high risk of GVHD, the actuarial incidence of grade II-IV acute GVHD was 28% (13% for HLA-identical siblings) with only 1 patient developing grade III-IV GVHD (after DLI). The actuarial 2-year probability of extensive chronic GVHD was similarly low (13% for all patients and 0% for HLA-identical siblings). Individual cases as well as a 30% relapse rate (0% for standard-risk patients versus 55% for high-risk patients) indicated preservation of the GVL effect. INTERPRETATION AND CONCLUSIONS: We conclude that allogeneic transplantation of CD34-selected PBSC followed by pre-emptive CD8-depleted DLI is feasible with rapid engraftment and minimizes the risk of severe GVHD. Large prospective trials are required to prove that it preserves the GVL effect fully. [less ▲]

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See detailComprendre et prévenir la violence à l'école : vers un référentiel critique des mesures actuelles de prévention et de lutte contre la violence scolaire
Munten, Jacqueline; Jardon, Dorothée; Mouvet, Bernadette ULg

in Point sur la Recherche en Education (Le) (2002), 22

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See detailLe Pr J.-M. Krzesinski (CHU sart Tilman, ULg) a sélectionné pour vous...
Krzesinski, Jean-Marie ULg

in Tempo Médical (2002), 240

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See detailTraces expérimentales d’emmanchement. Identification et caractéristiques
Rots, Veerle ULg; Pirnay, Louis; Pirson, Philippe et al

in Bulletin de la Société Royale Belge d'Etudes Géologiques et Archéologiques "Les Chercheurs de Wallonie" (2002), 41

Detailed reference viewed: 18 (2 ULg)