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See detailThe 4s-4p Transitions in Neutral Phosphorus
Biémont, Emile ULg; Martin, F.; Quinet, Pascal ULg et al

in Astronomy and Astrophysics (1994), 283

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See detailPathogenic Tracks in Fatigue Syndromes
Moutschen, Michel ULg; Triffaux, Jean-Marc ULg; Demonty, Jean ULg et al

in Acta Clinica Belgica (1994), 49(6), 274-89

This review analyses the recent literature devoted to two related fatigue syndromes: chronic fatigue syndrome (CFS) and acute onset postviral fatigue syndrome (PVFS). The articles are grouped into five ... [more ▼]

This review analyses the recent literature devoted to two related fatigue syndromes: chronic fatigue syndrome (CFS) and acute onset postviral fatigue syndrome (PVFS). The articles are grouped into five pathogenic tracks: infectious agents, immune system, skeletic muscle, hypothalamo-pituitary-adrenal (HPA) axis and psychiatric factors. Although a particular infectious agent is unlikely to be responsible for all CFS cases, evidence is shown that host-parasite relationships are modified in a large proportion of patients with chronic fatigue. Antibody titres against infectious agents are often elevated and replication of several viruses could be increased. Chronic activation of the immune system is also observed and could be due to the reactivation of persistent or latent infectious agents such as herpes viruses (i.e. HHV-6) or enteroviruses. It could also be favorised by an impaired negative feedback of the HPA axis on the immune system. A model is proposed where the abnormalities of the HPA axis are primary events and are mainly responsible for a chronic activation of the immune system which in turn induces an increased replication of several viruses under the control of cellular transcription factors. These replicating viruses together with cytokines such as TNF-alpha would secondarily induce functional disorders of muscle and several aspects of asthenia itself. [less ▲]

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See detailBrucellose enzootique à Brucella suis biotype 2 chez le sanglier (sus scrofa) en Belgique
Godfroid, J.; Michel, P.; Uytterhaegen, L. et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailLocalisation scintigraphique de tumeurs neuroendocrines et de leurs métastases par un analogue de la somatostatine: [111In-DTPA-d-phe1] octreotide
Beckers, Albert ULg; Pham, V. T.; Abs, R. et al

in Médecine & Chirurgie Digestives (1994), 23(3), 145-150

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See detailChloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content
Bettendorff, Lucien ULg; Hennuy, Benoît ULg; De Clerck, Anne et al

in Brain Research (1994), 652(1), 157-160

Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates ... [more ▼]

Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates, increased TTP content correlates with increased 36Cl- uptake. A hyperbolic relationship was obtained with a K0.5 of 0.27 nmol TTP/mg protein. In crude mitochondrial fractions from the brains of animals previously treated with thiamine or sulbutiamine, a positive correlation between 36Cl- uptake and TTP content was found. These results, together with other results previously obtained with the patch-clamp technique, suggest that TTP is an activator of chloride channels having a large unit conductance. [less ▲]

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See detailLe renouveau cosaque
Bachkatov, Nina ULg; Wilson, Andrew

in Transitions : Ex-Revue des Pays de L'est (1994), 35-1

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See detailCrystallization and X-ray diffraction study of the Streptomyces K15 penicillin-binding DD-transpeptidase.
Englebert, S.; Charlier, Paulette ULg; Fonze, E. et al

in Journal of Molecular Biology (1994), 241(2), 295-7

The 262 amino acid residue long DD-transpeptidase/penicillin-binding protein of Streptomyces K15 has been crystallized at room temperature by using the hanging drop vapour diffusion technique. The ... [more ▼]

The 262 amino acid residue long DD-transpeptidase/penicillin-binding protein of Streptomyces K15 has been crystallized at room temperature by using the hanging drop vapour diffusion technique. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a = 46.4 A, b = 54.1 A and c = 108.3 A. They contain one protein molecule per asymmetric unit and diffract to about 1.9 A. X-ray data have been collected to 2.0 A from a native crystal. The previously published amino acid sequence of the protein has been corrected at positions 71, 72, 113, 114 and 156. [less ▲]

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See detailEvaluation d’une expérience de rénovation de l’enseignement fondamental: Méthodologie de recherche
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine

in Revue de l'Education Physique (1994), 34(2-3), 117-120

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples ... [more ▼]

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples éclairages. Par les personnes auxquelles il s'adresse, par la diversité de ces effets et par l'organisation qu'il requiert, par la nécessité de mettre en évidence les relations de causalité, il a nécessité une méthodologie d'évaluation multidimensionnelle. ... [less ▲]

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See detailDynamique du carbone inorganique des eaux de surface dans l'embouchure de l'Escaut
Frankignoulle, Michel; Biondo, Renzo ULg; Bouquegneau, Jean-Marie ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 61

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See detailL’expérience pédagogique: «Rénovation de l’enseignement fondamental - Développement corporel des enfants de 21/2 ans à 12 ans».
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Informations pédagogiques (1994), 10

Delmelle (1992) a clairement défini la philosophie général de l'expérience pédagogique: "Compte tenu des besoins, des structures administratives en vigueur, des disponibilités matérielles et humaines et ... [more ▼]

Delmelle (1992) a clairement défini la philosophie général de l'expérience pédagogique: "Compte tenu des besoins, des structures administratives en vigueur, des disponibilités matérielles et humaines et des contraintes budgétaires, la commission a défini, de la manière suivante, la philosophie d'une rénovation possible à échéance immédiate. (a) Dans l'enseignement fondamental, tout enfant doit pratiquer l'activité physique à raison d'une séance quotidienne; il est parfaitement possible d'agir en sorte que les activités et les structures générales de l'école ne soient pas bouleversées. ..." ... [less ▲]

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See detailChiral restoration transition in scaled effective Lagrangians
Jaminon, Martine ULg; Van den Bossche, Bruno

in Zeitschrift für Physik. C, Particles and Fields (1994), 64

We make a systematic study of the chiral restoration transition in function of the two free parameters of two scaled effective NJL Lagrangians. We show that it is not possible to reproduce with the same ... [more ▼]

We make a systematic study of the chiral restoration transition in function of the two free parameters of two scaled effective NJL Lagrangians. We show that it is not possible to reproduce with the same set of parameters the temperature behaviours of the quark condensate and of the quark entropy and a critical density at least equal to the normal density of nuclear systems. [less ▲]

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See detailNescio als 'Animal Metaphysicum'
Yans, Baudoin ULg

in Spiegel der Letteren (1994), (1), 45-62

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See detailCytochemical and immunocytochemical study of coiled bodies in different cultured cell lines.
Thiry, Marc ULg

in Chromosoma (1994), 103(4), 268-76

We analyzed by different cytochemical and immunocytochemical approaches the biochemical compositon of coiled bodies in three different cultured cell lines. Coiled bodies are stained by the AgNOR staining ... [more ▼]

We analyzed by different cytochemical and immunocytochemical approaches the biochemical compositon of coiled bodies in three different cultured cell lines. Coiled bodies are stained by the AgNOR staining method and by the EDTA regressive staining method preferential for ribonucleoprotein (RNP). Using the in situ polyadenylate nucleotidyl transferase-immunogold technique or anti-RNA antibodies, we decisively demonstrated the presence of appreciable amounts of RNA in coiled bodies. Neither the in situ terminal deoxynucleotidyl transferase-immunogold technique nor anti-DNA antibodies revealed any DNA in coiled bodies. Coiled bodies thus appear as distinct regions of cell nuclei involved in some steps of RNA metabolism but not directly in RNA synthesis. Their relationships with the dense fibrillar component of the nucleolus and with interchromatin granule clusters are discussed. [less ▲]

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See detailDetailed Study of a Molecule in a Molecule N-Acetyl-L-Tryptophanamide in a Active-Site Model of Alpha-Chymotrypsin
Dive, Georges ULg; Dehareng, Dominique ULg; Ghuysen, Jean-Marie ULg

in Journal of the American Chemical Society (1994), 116(6), 2548-2556

Six complexes between a model active site of alpha-chymotrypsin (261 atoms) and N-acetyl-L-tryptophanamide (33 atoms) were optimized at the semiempirical AM1 level. In one of these complexes, a water ... [more ▼]

Six complexes between a model active site of alpha-chymotrypsin (261 atoms) and N-acetyl-L-tryptophanamide (33 atoms) were optimized at the semiempirical AM1 level. In one of these complexes, a water molecule was included. A detailed study at the geometric and energetic levels is presented. The discussion deals with the nature of the interaction, the effect of the environment, the ligand deformation, the backbone relaxation, the water molecule freedom, and the comparison with the molecular mechanics results. [less ▲]

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See detailVimentinoma, an Unusual Neoplasm of the Skin
Hermanns-Lê, Trinh ULg; Nikkels, Arjen ULg; Ammar et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1994), 189(1), 84-86

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and ... [more ▼]

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and electron microscopy. 'Vimentinoma' appears to be the most appropriate name for this neoplasm. [less ▲]

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See detailImidazolidinones structurally-related to penicillins: synthesis, molecular modeling and biological evalutation
Marchand-Brynaert, Jacqueline; Lamotte-Brasseur, Josette; Dive, Georges ULg

in Drug Metabolism and Drug Interactions (1994), 11(2), 85-109

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See detailMeasurement of Right Ventricular Ejection Fraction and Volume by the Thermodilution Technique in the Unsedated Calf
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1994), 56(1), 75-81

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end ... [more ▼]

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in unsedated cattle. In the 16 healthy calves studied, it was possible, using a fast response thermodilution catheter, to obtain characteristic exponential steplike washout curves, allowing the calculation of right ventricular EF, EDV and ESV. Five to 10 successive thermodilution curves were recorded within a few minutes and two to five similar sets of measurements were performed throughout the same day to test the reproducibility of the technique. The same protocol was repeated the following day. Right ventricular EF, EDV and ESV were reproducible successively, throughout a given day and on following days. The mean intraset, intraday and interdays coefficients of variation ranged from a mean of 4.0 (SD 4.1) per cent to a mean of 18.2 (SD 7.9) per cent. Values of right ventricular volumes and EF agreed with those previously reported in various animal species. Thermodilution was, therefore, shown to be a useful method for measuring with a satisfactory reproducibility, right ventricular EF, EDV and ESV in the unsedated healthy calf [less ▲]

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See detailAn isozyme study in Bilberry (Vaccinium myrtillus ) 2. Mating system and genetic structure
Jacquemart, Anne Laure; Mahy, Grégory ULg; Raspé, Olivier et al

in Belgian Journal of Botany (1994), 127

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See detailA note on the size-fractionated pigments of the phytoplankton of the Strait of Magellan (February-March 1991)
Saggiomo, Vincenzo; Mangoni, Olga; Borriello, C. et al

in Oebalia : International Journal of Marine Biology and Oceanography (1994), XX

During an oceanographic cruise, carried out at the end of the austral summer (February-March 1991) in the Strait of Magellan, spatial patterns of size-fractionated chlorophyll and primary production were ... [more ▼]

During an oceanographic cruise, carried out at the end of the austral summer (February-March 1991) in the Strait of Magellan, spatial patterns of size-fractionated chlorophyll and primary production were studied in relation to hydrographic patterns. Phytoplankton biomass, in terms of active Chl a, ranged between 10 and 51 mg m-2 and primary production between 275 and 1 170 mg C m-2 d-1. The most important features concern the confinement of the microphytoplanktonic fraction to the Pacific opening and to the embayements between the two Narrows. In the internal part of the Strait, an uniform dimensional structure (< 5 um) of phytoplankton communities was observed, with the picophytoplanktonic fraction always dominant. [less ▲]

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See detailInsulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.
Peers, Bernard ULg; Sharma, S.; Teitelman, G. et al

in Molecular Endocrinology (1994), 8(12), 1798-806

The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin ... [more ▼]

The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-expressing cells. The mechanism by which these peptide hormone genes are induced and then either maintained or repressed during development is unknown, but their coexpression in early precursor cells suggests the involvement of common regulatory factors. Here we show that the somatostatin transcription factor STF-1 is also a principal regulator of insulin expression in beta-cells of the pancreas. STF-1 stimulates the insulin gene by recognizing two well defined islet-specifying elements on the insulin promoter and by subsequently synergizing in trans with the juxtaposed helix-loop-helix protein E47. Within the STF-1 protein, an N-terminal trans-activation domain functions cooperatively with E47 to stimulate insulin transcription. As truncated STF-1 polypeptides lacking the N-terminal activation domain strongly inhibit insulin promoter activity in beta-islet cells, our results suggest that the specification of islet cell types during development may be in part determined by the expression of STF-1 relative to other islet cell factors. [less ▲]

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See detailL’éthique et l’animal. Eléments pour un débat
Ansay, M.; Delaunois, A.; Gustin, Pascal ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailSpatial patterns of phytoplanktonic pigments and primary production in a semi-enclosed periantarctic ecosystem: the Strait of Magellan
Saggiomo, Vincenzo; Goffart, Anne ULg; Carrada, Gian Carlo et al

in Journal of Marine Systems (1994), 5

The spatial patterns of nitrate, phytoplankton size-fractionated chlorophyll a, photosynthetic pigments detected by HPLC and primary production were studied at the end of the austral summer ... [more ▼]

The spatial patterns of nitrate, phytoplankton size-fractionated chlorophyll a, photosynthetic pigments detected by HPLC and primary production were studied at the end of the austral summer (February–March 1991), in the Strait of Magellan to provide insight into the mechanisms governing this seemi-enclosed periantartic ecosystem. Climatological peculiarities, hydrodynamic constraints, runoff and land forcing were considered. The most important features identified for this area were the confinement of the microphytoplankton fraction to the external parts of the Strait and the rather uniform dimensional structure of the phytoplankton communities ( < 5 μm) within the internal sectors. In particular, the nanoplanktonic fraction (10 - 2 μm) comprised 33 %, while the picoplanktonic one (2 - 0.5 μm) represented 62% of the total. The concentration of active Chl. a and plant pigments detected by HPLC, nitrate and primary production showed an uneven but similar distribution, allowing for the characterization of different sectors within the Strait, according to different types and intensities of forcing factors. The different ecological sectors identified along the Strait were associated with distinct hydrographic typologies: an oligotrophic, wind-mixed coastal area, adjacent to the Pacific opening; a high runoff fjord and a divergence zone in the Andean sectors; a stratified inland sea in the basin-like part of the channel (Paso Ancho) and a shallow, tidally mixed system in the Patagonian sectors. Areas of relatively low and high phytoplankton biomass and primary production alternate along the Strait, according to the hydrographic structures of the different sectors. Phytoplankton biomass, in terms of active Chl. a (spectrofluorometric determination) ranged between 10 and 51 mg m−2 and primary production between 275 and 1170 mg C m−2 d−1. The assemblage of plant pigments detected by HPLC indicated that the high levels of phytoplankton pigments and production were most likely attributable to Chlorophytes, Prasinophytes, Prymnesiophytes and/or Gyrodinium and Gymnodinium-like Dinoflagellates that were submitted to natural senescence and to superfluous feeding activity; while, when Diatoms, Cryptomonads and Prymnesiophytes were dominant, efficient zooplankton grazing occurred and characterized a balanced food chain. The spatial distribution of the parameters considered was related to hydrologic conditions indicating a Pacific water influence in the entire channel. [less ▲]

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See detailPilgrimage out of Dispossession
Pagnoulle, Christine ULg

in Commonwealth : Essays and Studies (1994), 17(1), 100-106

Goodison's poems testify to her proud self-assertion, both as woman and as a descendant of African slaves.

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See detailEstimation of effective and total erythropoiesis in myelodysplasia using serum transferrin receptor and erythropoietin concentrations, with automated reticulocyte parameters.
Bowen, D. T.; Culligan, D.; Beguin, Yves ULg et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1994), 8(1), 151-5

The erythroid abnormality in patients with myelodysplasia (MDS) is multifactorial, with ineffective erythropoiesis and poor in vitro progenitor response to erythropoietin (EPO). Serum EPO concentration is ... [more ▼]

The erythroid abnormality in patients with myelodysplasia (MDS) is multifactorial, with ineffective erythropoiesis and poor in vitro progenitor response to erythropoietin (EPO). Serum EPO concentration is variable among patients for a given haemoglobin concentration. We studied 19 non-transfusion-dependent patients with MDS, and 13 healthy elderly control subjects in an attempt to define the factors governing variability in serum EPO and to further characterise the anaemia of MDS. Serum EPO concentration was appropriate for the degree of anaemia in 15/19 MDS patients, and was positively related to mean cell volume (MCV), mean cell haemoglobin (MCH), and percentage highly fluorescent reticulocytes (% HFR), but not to absolute or percentage reticulocyte count. Although the observed/predicted ratio for serum transferrin receptor (TfR) concentration was low in 12 of 19 MDS subjects, no relationship to haemoglobin concentration, reticulocytes or serum EPO was seen. Serum TfR was positively correlated with WBC and platelet counts. Serum TfR was higher in patients with sideroblastic anaemia than refractory anaemia. Standardized in vivo p50 was positively correlated to red cell 2,3 diphosphoglycerate concentration, although this was not the only factor influencing the oxygen dissociation curve. We conclude that effective erythroid output responsive to endogenous EPO drive in MDS is positively related to MCV, MCH and % HFR. Serum TfR may not represent effective output as precisely as % HFR, but may be proportional to total marrow erythropoietic activity. [less ▲]

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See detailEssai sur le rythme statuaire à la période protohistorique en Mésopotamie
Tunca, Önhan ULg

in Beiträge zur Altorientalischen Archäologie und Altertumskunde (1994)

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See detailObservations on the establishment of a Devonian and Lower Carboniferous high resolution miospore biostratigraphy
Streel, Maurice ULg; Loboziak, S

in Review of Palaeobotany and Palynology (1994), 83

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See detailA fuzzy approach to the definition of standardized visibility in fog.
Boreux, Jean-Jacques ULg; Duckstein, Lucien

in Applied Mathematics and Computation (1994), 61(2-3), 287-299

The problem of defining the physical concept of standardized visibility is addressed by means of a fuzzy logic approach. Assuming that several hypotheses hold, it is possible to evaluate a standardized ... [more ▼]

The problem of defining the physical concept of standardized visibility is addressed by means of a fuzzy logic approach. Assuming that several hypotheses hold, it is possible to evaluate a standardized visibility Vk (or meteorological visual range) as the ratio of a psychometric coefficient k and the extinction coefficient σ of the aerosol. The main disadvantage of this relationship due to Koschmieder stems from the fact that the meteorological visual range can be very different from visibility estimated by a human observer with normal sight. This is particularly true during fog extinction coefficient supplied by a transmissometer and the corresponding visibility evaluated by an expert. Calculations are performed according to two different approaches. First, a so-called fuzzy hyperbolic model based on a distance defined by Bardossy et al is presented, yielding a crisp (nonfuzzy) value of the coefficient k. Next, we use the multiplication of two fuzzy numbers, taken as triangular, to build an average fuzzy number k that accounts for the different values found in the literature. The defuzzification of k confirms the result obtained by the first approach. [less ▲]

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See detailLe genre Peltigera (Lichenes) en Belgique et au Grand-Duché de Luxembourg
Goffinet, Bernard; Sérusiaux, Emmanuël ULg; Diederich, Paul

in Belgian Journal of Botany (1994), 127

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See detailThe mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.
Wilkin, J M; Dubus, Alice ULg; Joris, Bernard ULg et al

in Biochemical Journal (1994), 301 ( Pt 2)

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the ... [more ▼]

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the active-site cavity. Thr299 corresponds to the second residue of the Lys-Thr(Ser)-Gly triad, highly conserved in active-site beta-lactamases and penicillin-binding proteins (PBPs). Modification of Thr301 resulted only in minor alterations of the catalytic and penicillin-binding properties of the enzyme. No selective decrease of the rate of acylation was observed for any particular class of compounds. By contrast, the loss of the hydroxy group of the residue in position 299 yielded a seriously impaired enzyme. The rates of inactivation by penicillins were decreased 30-50-fold, whereas the reactions with cephalosporins were even more affected. The efficiency of hydrolysis against the peptide substrate was also seriously decreased. More surprisingly, the mutant was completely unable to catalyse transpeptidation reactions. The conservation of an hydroxylated residue in this position in PBPs is thus easily explained by these results. [less ▲]

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See detailGalectins: a family of animal beta-galactoside-binding lectins.
Barondes, S. H.; Castronovo, Vincenzo ULg; Cooper, D. N. et al

in Cell (1994), 76(4), 597-8

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See detailTamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype
Bracke, M. E.; Charlier, Corinne ULg; Bruyneel, E. A. et al

in Cancer Research (1994), 54

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Bouwen met Staal (1994), n°117

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See detailMaastricht in beweging. Enkele bedenkingen na het Belgisch voorzitterschap van de Europese Unie
Flore, Daniel ULg; Troosters, R.

in Panopticon : Tijdschrift voor Strafrecht, Criminologie en Forensisch Welzijnswerk (1994)

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See detailB.E.M.S. : Batterie d'Evaluation de la Morpho-Syntaxe : développement, évaluation, et lignes d'action
Fayasse, M.; Comblain, Annick ULg; Rondal, Jean-Adolphe ULg

in Informations pédagogiques (1994), 12

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See detailAssessment of the new immunological test Hemoblot for detecting occult blood in faeces
Jeanson, Antoinette; Jamart, J.; Maisin, J. M. et al

in European Journal of Cancer Prevention (1994), 3(5), 407-412

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and ... [more ▼]

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and with a guaiac test (Hemoccult II, SmithKline Diagnostics). The analytical sensitivity of Hemoblot is 0.15 mg haemoglobin/g faeces and the test is specific for human haemoglobin. In addition, 135 symptomatic patients who had to undergo a colonoscopy were tested using the three tests. Two criteria were considered for the analysis: (1) the blood criterion: any pathology likely to cause colorectal or other bleeding; and (2) the precancerous-cancerous criterion: the pathology being either a colorectal polyp > 0.5 cm or a colorectal cancer. Considering both criteria, the sensitivity of Hemoblot was significantly higher than the sensitivity of Hemoccult: 38% and 23%, respectively, for the blood criterion; and 54% and 29% for the precancerous-cancerous criterion. Sensitivity and specificity did not differ statistically between Hemoblot and HemeSelect but Hemoblot was faster and simpler to perform. It could be widely used in mass screening. [less ▲]

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See detailChemically selected subclones of the CEM cell line demonstrate resistance to HIV-1 infection resulting from a selective loss of NF-kappa B DNA binding proteins.
Qian, J.; Bours, Vincent ULg; Manischewitz, J. et al

in Journal of Immunology (1994), 152(8), 4183-91

To delineate cellular genes that are required for optimal HIV-1 infection, CEM cells were subjected to treatment with the chemical mutagen ethylmethanesulfonate (EMS) and subclones were selected based on ... [more ▼]

To delineate cellular genes that are required for optimal HIV-1 infection, CEM cells were subjected to treatment with the chemical mutagen ethylmethanesulfonate (EMS) and subclones were selected based on their increased resistance to HIV-1 infection and reduced syncytium formation, despite relatively normal CD4 expression (20,000 to 25,000 receptors/cell). Two subclones with this phenotype demonstrated a diminished capacity of HIV-1 long terminal repeat-chloramphenicol acetyl transferase expression either after treatment with the protein kinase C activator PMA, or through Tat-mediated transactivation. In this study, we show that the cellular levels of the NF-kappa B DNA binding proteins (but not AP1 or SP1) are markedly reduced in these cell mutants both at the mRNA and protein levels, resulting in reduced nuclear localization of p50/p65 after PMA induction or treatment with the lymphokine TNF-alpha. Transient reconstitution with a plasmid expressing p50 resulted in partial recovery of PMA-inducible LTR-chloramphenicol acetyl transferase expression. These data suggest that, at least in the CEM T cell line, a selective reduction in the NF-kappa B DNA binding proteins is sufficient to curtail HIV-1 infection. [less ▲]

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See detailLa formation des agents de santé scolaire dans le cadre du programme "Je mange bien à l'école"
Vandoorne, Chantal ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), (3),

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See detailMultiphase Saturation Curves of the Oxoglutarate Carrier : A mathematical Model
Holzhütter, H.-G.; Sluse-Goffart, C.; Sluse, Francis ULg

in Mathematical & Computer Modelling (1994), 19(6-8), 263-272

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See detailLate Devonian-Early Carboniferous miospores from the Menen borehole, Namur Synclinorium, Belgium
Loboziak, S.; Streel, Maurice ULg; Dusar, M. et al

in Review of Palaeobotany and Palynology (1994), 80(1/2), 55-63

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See detailMassive Ketonuria During Sedation with Propofol in a 12 Year Old Girl with Severe Head Trauma
Canivet, Jean-Luc ULg; Gustad, K.; Leclercq, P. et al

in Acta Anaesthesiologica Belgica (1994), 45(1), 19-22

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial ... [more ▼]

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial hypertension; as a part of our management protocol, glucose intake was restricted to 5 Kcal/h. After 18 hours of propofol infusion there was intense ketonuria (8+ by Ketostix) without any evidence of metabolic acidosis (pH, HCO3- and anion gap were within normal values). At this time, indirect calorimetry (Deltatrac) confirmed that energy expenditure was principally based on fat consumption (70% of energy expenditure). Lowering the propofol infusion rate and increasing glucose intake reduced fat consumption to 39% within 8 hours: at this time, Ketostix was negative for ketone bodies. This case illustrates a potential risk of ketonuria during prolonged sedation with propofol (a 10% solution of intralipid), particularly if glucose intake is restricted. Monitoring urinary ketone bodies is recommended under these circumstances. [less ▲]

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See detailLa Shoah ne fut pas un spectacle. A propos de La liste de Schindler
Delruelle, Edouard ULg

in Cahiers de Clio (1994), 117(11),

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See detailAvailability of glucose ingested during muscle exercise performed under acipimox-induced lipolysis blockade.
Gautier, J. F.; Pirnay, Freddy ULg; Jandrain, Bernard ULg et al

in European Journal of Applied Physiology and Occupational Physiology (1994), 68(5), 406-12

This study investigated the percentage of carbohydrate utilization than can be accounted for by glucose ingested during exercise performed after the ingestion of the potent lipolysis inhibitor Acipimox ... [more ▼]

This study investigated the percentage of carbohydrate utilization than can be accounted for by glucose ingested during exercise performed after the ingestion of the potent lipolysis inhibitor Acipimox. Six healthy male volunteers exercised for 3 h on a treadmill at about 45% of their maximal oxygen uptake, 75 min after having ingested 250 mg of Acipimox. After 15-min adaptation to exercise, they ingested either glucose dissolved in water, 50 g at time 0 min and 25 g at time 60 and 120 min (glucose, G) or sweetened water (control, C). Naturally labelled [13C]glucose was used to follow the conversion of the ingested glucose to expired-air CO2. Acipimox inhibited lipolysis in a similar manner in both experimental conditions. This was reflected by an almost complete suppression of the exercise-induced increase in plasma free fatty acid and glycerol and by an almost constant rate of lipid oxidation. Total carbohydrate oxidation evaluated by indirect calorimetry, was similar in both experimental conditions [C, 182, (SEM 21); G, 194 (SEM 16) g.3 h-1], as was lipid oxidation [C, 57 (SEM 6); G, 61 (SEM 3) g.3 h-1]. Exogenous glucose oxidation during exercise G, calculated by the changes in 13C:12C ratio of expired air CO2, averaged 66 (SEM 5) g.3 h-1 (19% of the total energy requirement). Consequently, endogenous carbohydrate utilization was significantly smaller after glucose than after placebo ingestion: 128 (SEM 18) versus 182 (SEM 21) g.3 h-1, respectively (P < 0.05). Symptoms of intense fatigue and leg cramps observed with intake of sweet placebo were absent with glucose ingestion.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailModifier les représentations de l'échec à l'école normale
Beckers, Jacqueline ULg

in Recherche en Education. Théorie & Pratique (1994), 18-19

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See detailLongwave Sky Radiation Parametrizations
Aubinet, Marc ULg

in Solar Energy (1994), 53(2),

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See detailBovine Growth Hormone-Taqi Rflp And Quantitative Traits Breed Selected For Growth Performances And Meat Production
Sneyers, M.; Renaville, Robert ULg; Falaki, M. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1994), 102(2),

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See detailLa maladie de Lyme : une nouvelle maladie?
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailDetection des molecules responsables de l'activite biocide des feuilles de Boscia senegalensis (Pers.) Lam ex Poir. par echantillonage d'espace de tete et spectrometrie de masse couplee a la chromatographie en phase gazeuse.
Lognay, Georges ULg; Marlier, M.; Seck, D. et al

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(1),

Des échantillons de feuilles de Boscia senegalensis (Prns.) I.ev ex Porn. ont été tnaintenus dans des conditions contrôlées sous un flux d'hélium, à l'intérieur d'une.platine de désorption thermique ... [more ▼]

Des échantillons de feuilles de Boscia senegalensis (Prns.) I.ev ex Porn. ont été tnaintenus dans des conditions contrôlées sous un flux d'hélium, à l'intérieur d'une.platine de désorption thermique directement connectée à un GC-MS. A côté du trans-2-hexénal, responsable de la note "verte" des feuilles, l'isothiocyanate de méthyle et le cyanure de méthyle (acétonitrile) ont été détectés. Ces deux produits se sont formés par dégradation enzymatique in situ d'un précurseur, la glucocapparine. Ils ont été caractérisés par leur spectre de masse. La libération de cyanure de méthyle à partir d'échantillons biologiques est expliquée. [less ▲]

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See detailTherapy for obesity--today and tomorrow.
Scheen, André ULg; Desaive, Claude ULg; Lefebvre, Pierre ULg

in Bailliere's Clinical Endocrinology and Metabolism (1994), 8(3), 705-27

Obesity poses a serious health hazard and its treatment is often disappointing. Besides conservative methods, the place of pharmacotherapy, very-low-calorie diets, and even, in selected cases, mechanical ... [more ▼]

Obesity poses a serious health hazard and its treatment is often disappointing. Besides conservative methods, the place of pharmacotherapy, very-low-calorie diets, and even, in selected cases, mechanical means or surgery can be considered. Effective drug treatment for obesity must reduce energy intake, or increase energy expenditure, or increase energy losses in faeces. All these possibilities have potential activities but also serious limitations. Current pharmacotherapy essentially uses anorectic drugs and the other approaches, although promising, are still under investigation. Of the anorectic compounds currently available, serotoninergic agents, like dexfenfluramine and fluoxetine, appear to have the most suitable pharmacological profile. Very-low-calorie diets could help in the short-term but should be associated with other approaches to increase the rate of long-term success. They must be well-balanced as macronutrients and micronutrients are concerned, be prescribed in well-selected patients under careful medical supervision, and not be followed longer than a few weeks. Surgery can provide palliation for severe obesity when all medical approaches have failed. It may consist in decreasing food intake (gastric procedures), affecting calorie absorption (intestinal shunting, biliopancreatic bypass), or removing localized excess fat (lipectomy, liposuction). Gastric reduction operations are safe and effective provided they are performed by experienced surgeons in well-selected patients. They can be considered now as the best option for a minority of patients with morbid and refractory obesity. Finally, in very selected patients, mechanical means (such as the waist cord) may also help losing weight and/or avoiding weight regain. Even if all these therapeutic approaches can be helpful, at least in some obese individuals, they also have important limitations so that prevention remains up to now the 'treatment' of choice for obesity. [less ▲]

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See detailINTERNATIONAL-CONFERENCE ON BARBUS - PRESENT AND FUTURE - FOREWORD
BERREBI, P.; Poncin, Pascal ULg

in Bulletin Francais De La Peche Et De La Pisciculture (1994), (334), 167-168

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See detailChanges in glucose turnover parameters and improvement of glucose oxidation after 4-week magnesium administration in elderly noninsulin-dependent (type II) diabetic patients.
Paolisso, G.; Scheen, André ULg; Cozzolino, D. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 78(6), 1510-4

The aim of the present study was to investigate the effects of magnesium supplementation on glucose uptake and substrate oxidation in noninsulin-dependent (type II) diabetic patients. Nine elderly non ... [more ▼]

The aim of the present study was to investigate the effects of magnesium supplementation on glucose uptake and substrate oxidation in noninsulin-dependent (type II) diabetic patients. Nine elderly non-obese noninsulin-dependent (type II) diabetic patients, treated by diet only, participated in the study, which was designed as randomized, double blind, and cross-over. Each patient was followed up for a prestudy period of 3 weeks before inviting him/her to receive placebo or magnesium supplementation (15.8 mmol/day) for 4 weeks. At the end of each treatment period, a euglycemic hyperinsulinemic glucose clamp with simultaneous D-[3-3H]glucose infusion and indirect calorimetry was performed. Magnesium supplementation resulted in significantly increased plasma and erythrocyte magnesium levels, whereas body weight and fasting plasma glucose did not change. In the last 60 min of the glucose clamp, insulin-mediated glucose disappearance, total body glucose disposal (24.5 +/- 0.4 vs. 28.2 +/- 0.7 mumol/kg.min; P < 0.005), and glucose oxidation (13.0 +/- 0.4 vs. 16.3 +/- 0.8 mumol/kg.min; P < 0.01) were increased after chronic magnesium supplementation. Endogenous glucose production, nonoxidative glucose disposal, lipid and protein oxidation, and insulin MCR were not affected. In conclusion, a 4-week magnesium supplementation improves insulin sensitivity and glucose oxidation in the course of a euglycemic-hyperinsulinemic glucose clamp in noninsulin-dependent diabetic patients. Long term studies are needed to determine whether magnesium supplementation is useful in the management of type II diabetes. [less ▲]

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See detailA propos d'un cas de kératite a Mycobacterium chelonae
Duchesne, Bernard ULg; Marechal-Courtois; Melin, Pierrette ULg

in Bulletin de la Société Belge d'Ophtalmologie (1994), 254

The authors presents one case of primitive corneal mycobacterium keratitis after corneal graft. This rare form of keratitis is analysed in the field of mycobacterial infections who's nowadays more ... [more ▼]

The authors presents one case of primitive corneal mycobacterium keratitis after corneal graft. This rare form of keratitis is analysed in the field of mycobacterial infections who's nowadays more developed in our industrialised countries. The description of the case point out the multiresistance of this mycobacterium and describe the different treatments. [less ▲]

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See detailMetabolic clearance rate of insulin in type 2 diabetic patients treated with combined insulin and sulfonylurea therapy.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Revista Espanola de Fisiologia (1994), 50(1), 27-34

The metabolic clearance rate of insulin (MCRI) in 10 non-obese type 2 diabetic patients treated with either insulin alone or combined insulin plus sulfonylurea therapy is investigated. A classical 2-hour ... [more ▼]

The metabolic clearance rate of insulin (MCRI) in 10 non-obese type 2 diabetic patients treated with either insulin alone or combined insulin plus sulfonylurea therapy is investigated. A classical 2-hour euglycaemic hyperinsulinaemic glucose clamp using the artificial pancreas was performed in a randomized order after two 6-week periods of treatment: either with subcutaneous injections of insulin alone or with insulin plus oral administration of the sulfonylurea compound glipizide at the dose of 3 x 10 mg/day. The MCRI was calculated knowing the constant insulin infusion rate (0.1 U.kg-1.h-1) and measuring basal and steady-state plasma free insulin and C-peptide levels. When the test was performed at the end of the period of treatment with insulin plus glipizide and 30 min after the ingestion of the last dose of 10 mg glipizide, plasma C-peptide levels were significantly increased and steady-state free insulin levels tended to be slightly higher whereas the metabolic clearance rate of glucose was not affected. The MCRI was significantly reduced by glipizide from 23.3 +/- 2.9 to 18.9 +/- 2.0 ml.kg-1.min-1 p < 0.05. These results demonstrate that the sulfonylurea glipizide decreases the MCRI. This effect may play a role in the hypoglycemic action of sulfonylureas. [less ▲]

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See detailUse Of Bacteria Protections In Pelleting For Preinoculation Of Bean-Seeds (Phaseolus-Vulgaris L)
Jansen, Jp.; Schiffers, Bruno ULg; Mathot, P. et al

in Seed Science and Technology (1994), 22(2), 329-336

Preinoculation of bean seeds (Phaseolus vulgaris L.) with Rhibozium phaseoli material has been carried out by incorporating the inoculum in seed pelleting. An inoculum was incorporated into a mixture of ... [more ▼]

Preinoculation of bean seeds (Phaseolus vulgaris L.) with Rhibozium phaseoli material has been carried out by incorporating the inoculum in seed pelleting. An inoculum was incorporated into a mixture of vermiculite and compost or wheat bran, and applied to seeds to produce a solid pellet. The pelleted seed contained a sufficient number of bacteria per seed for effective nodulation after 56 days storage of preinoculated pelleted seeds at 25°C. Those results are not achieved using a liquid inoculum of Rhibozium. [less ▲]

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See detailDistribution and Regulation of Estrogen-2-Hydroxylase in the Quail Brain
Balthazart, Jacques ULg; Stoop, R.; Foidart, Agnès ULg et al

in Brain Research Bulletin (1994), 35(4), 339-45

The anatomical distribution and endocrine regulation of the estrogen-2-hydroxylase activity were investigated in the brain of adult male and female Japanese quail. Significant levels of enzymatic activity ... [more ▼]

The anatomical distribution and endocrine regulation of the estrogen-2-hydroxylase activity were investigated in the brain of adult male and female Japanese quail. Significant levels of enzymatic activity were detected in all brain regions that were studied, but the highest levels were observed in preoptic and hypothalamic brain nuclei that are known to contain high levels of aromatase activity. These data are consistent with previous results suggesting that the placental aromatase is also responsible for the estrogen-2-hydroxylase activity. However, there is a marked sex difference and a control by T of aromatase activity in the quail brain, and no such difference in 2-hydroxylase activity could generally be detected except in the VMN. Further studies will be needed to know whether the previously published conclusions concerning the human placenta also apply to the brain. The present data are consistent with the idea that estrogens formed locally in the brain by testosterone aromatization could affect reproduction by interfering with the catecholaminergic transmission after being metabolized into catechol-estrogens. [less ▲]

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See detailModeles lineaires en genetique quantitative: synthese des connaissances actuelles.
Gengler, Nicolas ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(1),

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See detailGrowth-inhibiting effects of a neem-based insecticide (Margosan-O) against Spodoptera littoralis (Lepidoptera: Noctuidae
Haubruge, Eric ULg; Seck, Dogo; Hemptinne, Jean-Louis et al

in Insect Science and its application (1994), 15(4), 243-249

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See detailEffects of immunization against somatostatin on growth performances and growth hormone - insulin-like growth factor I and insulin plasma levels in young bulls.
Renaville, Robert ULg; Sneyers, M.; Massart, Serge et al

in Zootecnica e Nutrizione Animale (1994), 20(4),

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See detailInvestigation of the Western Mediterranean's hydrodynamics with the GHER three-dimensional primitive equation model
Beckers, Jean-Marie ULg; Brasseur, P.; Djenidi, Salim ULg et al

in Coastal and Estuarine Studies (1994), 46

A three-dimensional, non-linear, primitive equation model with turbulent closure developed at the GeoHydrodynamics and Environment Research Laboratory (GHER), University of Liège, is designed to define ... [more ▼]

A three-dimensional, non-linear, primitive equation model with turbulent closure developed at the GeoHydrodynamics and Environment Research Laboratory (GHER), University of Liège, is designed to define marine weather-like processes ranging from mesoscale tides and storm surges, to synoptic frontal and eddy structures, to macroscale slowly-varying currents characteristic of the so-called “general circulation”. The model is applied here to the study of the hydrodynamics of the western Mediterranean as both a metagnostic (i.e. system-oriented) model and a diagnostic (i.e. process-oriented) model with both models allowed to run simultaneously and interactively. Critical processes such as deep water formation and the instabilities of the Algerian Current, are studied to provide a basic understanding of the physics needed to adequately parameterize sub-grid scale processes in the basin wide metagnostic model. This general circulation model provides boundary conditions for the finer grid diagnostic studies as well as the general overview of the basin's hydrodynamics. Further improvement is achieved by concurrent use of a variational inverse model to provide initial data fields and boundary conditions for the direct model. In turn, the metagnostic model provides hydrodynamic constraints which are imposed to the variational principle to ensure an interpolation/extrapolation of data compatible with the system's hydrodynamics. Results viz (i) a diagnostic study of the Algerian Current, (ii) a metagnostic study of the seasonal variability of the western Mediterranean Sea, are presented and compared with observations and with results of simpler (quasi-geostrophic, reduced gravity, etc.) models. Possible improved hydrodynamic forecasts of seasonal and interannual variability with the 3D primitive equation model is discussed with particular attention to the forecast's sensitivity to initial and boundary conditions. [less ▲]

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See detailExpression and function of DRC-1 antigen.
Bosseloir, A. L.; Antoine, Nadine ULg; Heinen, Ernst ULg et al

in Advances in Experimental Medicine and Biology (1994), 355

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See detailRelationship between alpha 2-adrenergic function and suicidal behavior in depressed patients.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Psychiatry Research (1994), 52(2), 115-23

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible implication of the noradrenergic function. In the present study, we assessed the growth hormone response to clonidine, a selective alpha 2-adrenergic agonist, in 15 DSM-III-R major depressive inpatients with a history of suicide attempts, compared with 15 age- and gender-matched major depressive inpatients without a history of suicidal behavior. Mean (+/- SD) growth hormone peak responses to clonidine were significantly lower in the group of suicide attempters than in the control group: 2.93 +/- 3.01 ng/ml vs. 8.28 +/- 8.15 ng/ml. Therefore, these results suggest that a blunted growth hormone response to clonidine could be a biological correlate of suicidal behavior. [less ▲]

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1994), 37

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair ... [more ▼]

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair haemodynamics in calves. Central venous, pulmonary arterial and capillary wedge and systemic arterial pressures were measured by fluid-filled catheters in 11 calves. Cardiac output was measured by the thermodilution technique, heart rate (HR) was derived from the ECG and stroke volume (SV), pulmonary and systemic vascular resistance were calculated. The haemodynamic values were measured hourly from the first to the tenth hour alter intratracheal inoculation of P. haemolytica. Cardiovascular response was marked and typically consisted of two hypotensive hypodynamic phases. The first, which occurred by the second hour after inoculation, consisted of a transient bradycardia and a systemic vasodilation leading to profound hypotension and reduced venous return. Cardiac performance then recovered, but systemic hypotension persisted and hypoxaemia developed. The second phase occurred by the seventh hour alter inoculation and was associated with a decline in SV, an increase in HR, and pulmonary hypertension. Three different degrees of cardiovascular dysfunctions were found, differing basically in the intensity of the first phase bradycardia and second phase reduction in SV and systemic arterial pressure, suggesting that experimental pneumonia produced by intratracheal instillation of P. haemolytica in calves results in distinct cardiovascular dysfunctions depending on the animal. Ignorance of the underlying haemodynamic status therefore precludes reliable interpretation of physiological as well as pharmacological results using this model of respiratory disease [less ▲]

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See detailOnce-a-day administration of amikacin in neonates: clinical evidence of the validity of a pharmacokinetic according to the gestational age
Battisti, Oreste ULg; Wallemacq P; Langhendries JP

in Early Human Development (1994), 38

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See detailLa reproduction des poissons de nos rivières.
Poncin, Pascal ULg

in Cahiers d'Ethologie (1994), 13(3), 317-342

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See detailSynthesis of barium-titanate by the sol-gel process
LEMOINE, Christine; Gilbert, Bernard ULg; MICHAUX, Bernard et al

in Journal of Non-Crystalline Solids (1994), 175(1), 1-13

Homogeneous BaTiO3 gels were prepared by hydrolysis and polycondensation reactions between titanium isopropoxide and barium hydroxide in the presence of methoxyethanol, methanol and water. Gel formation ... [more ▼]

Homogeneous BaTiO3 gels were prepared by hydrolysis and polycondensation reactions between titanium isopropoxide and barium hydroxide in the presence of methoxyethanol, methanol and water. Gel formation mechanisms were investigated by Raman scattering spectrometry. Two drying methods are carried out: either in air with a possible formation of barium carbonate or in a vacuum furnace, sheltered from CO2. The influence of the drying method on texture is studied through nitrogen adsorption-desorption isotherm analyses. A heat treatment is deduced from thermogravimetry and differential scanning calorimetry results. The influence of the calcining temperature on the texture and the crystallization of the solids has been measured. For the first time, the transformation at 900 degrees C from the cubic to the tetragonal form of BaTiO3 has been observed by polarization microscopy. [less ▲]

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See detailConditional watershed segmentation for grain boundary reconstruction
Pirard, Eric ULg; Delanaye, Annick ULg

in Acta Stereologica (1994), 14(1), 23-28

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See detailImprovement Of Enzymatic-Synthesis Yields Of Flavor Acetates - The Example Of The Isoamyl Acetate
Razafindralambo, Hary ULg; Blecker, Christophe ULg; Lognay, Georges ULg et al

in Biotechnology Letters (1994), 16(3), 247-250

Isoamyl acetate synthesis was chosen as a model to improve flavour acetate yields by optimising the enzymatic reaction. Alcohol:acid molar ratio, temperature, water content and amount of enzyme effects ... [more ▼]

Isoamyl acetate synthesis was chosen as a model to improve flavour acetate yields by optimising the enzymatic reaction. Alcohol:acid molar ratio, temperature, water content and amount of enzyme effects were analyzed. The optimum values were respectively 4, 45 degrees C, 0,1% (w/v) and 0,5 g. In these conditions, the synthesis yield reached 80% after 24 h of reaction and was found 15 times greater than those already reported in the literature. [less ▲]

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See detailMechanism of Thiamine Transport in Neuroblastoma Cells. Inhibition of a High Affinity Carrier by Sodium Channel Activators and Dependence of Thiamine Uptake on Membrane Potential and Intracellular Atp
Bettendorff, Lucien ULg; Wins, Pierre

in Journal of Biological Chemistry (1994), 269(20), 14379-14385

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a ... [more ▼]

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a saturable high affinity mechanism (Km = 35 nM). This was blocked by low concentrations of the Na+ channel activators veratridine (IC50 = 7 +/- 4 microM) and batrachotoxin (IC50 = 0.9 microM). These effects were not antagonized by tetrodotoxin and were also observed in cell lines devoid of Na+ channels, suggesting that these channels are not involved in the mechanism of inhibition. At high extracellular concentrations, thiamine uptake proceeds essentially via a low affinity carrier (Km = 0.8 mM), insensitive to veratridine but blocked by divalent cations. In both cases, the uptake was independent on external sodium, partially inhibited (10-35%) by depolarization and sensitive to metabolic inhibitors. A linear relationship between the rate of thiamine transport and intracellular ATP concentration was found. When cells grown in a medium of low thiamine concentration (6 nM) were exposed to 100 nM extracellular thiamine, a 3-fold increase in intracellular thiamine diphosphate was observed after 2 h while the concomitant increase in intracellular free thiamine was barely significant. These data suggest a secondary active transport of thiamine, the main driving force being thiamine phosphorylation rather than the sodium gradient. [less ▲]

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See detailChloride and Inorganic Phosphate Modulate Binding of Oxygen to Bovine Red Blood Cells
Gustin, Pascal ULg; Detry, Benoît; Cao, M. L. et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1994), 77(1), 202-208

The influence of Pi and Cl on the equilibrium of oxygen binding to bovine red blood cells was assessed by plotting the whole blood oxygen dissociation curve measured under standard conditions with and ... [more ▼]

The influence of Pi and Cl on the equilibrium of oxygen binding to bovine red blood cells was assessed by plotting the whole blood oxygen dissociation curve measured under standard conditions with and without added KCl and K2HPO4. Both salts shifted the oxygen dissociation curve to the right. This effect was more marked at the highest saturation levels. At a given saturation level, the anion-induced shift was linearly related to the concentration of salt added to the blood. Cl had a greater effect than Pi. The relationship between changes in Po2 at 50% hemoglobin saturation (in Torr) and concentrations of ions added (in mmol/l) was equal to 0.0515[Cl] + 0.0302[Pi] (r2 = 0.94; P < 0.001). These changes were not due to the hyperosmolality induced by salt addition, since sucrose added in place of salts was without effect on the measured parameters. The oxygen exchange fraction expressed as percentage of saturation, i.e., the difference in hemoglobin saturation when Po2 decreases from 130 to 40 Torr, was linearly correlated to added anion concentration (in mmol/l) (= 0.102[Cl] + 0.059[Pi] (r2 = 0.95; P < 0.001)). No significant interaction between the anions was observed; their effects were purely additive. This original mechanism of controlling the oxygen affinity of bovine blood may have clinical relevance: Cl and Pi could be used to increase oxygen transport efficiency in hypoxic animals [less ▲]

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See detailTylosema fassoglensis (Kotschy) Torre and Hillc.: a lesser knownplant
Dubois, M.; Malaisse, François ULg; Buyck, B. et al

in Cahiers d'Etudes et de Recherches Francophones. Agricultures (1994), 3

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See detailLes manifestations neurologiques de l'infection a Borrelia burgdorferi (maladie de Lyme).
PEPIN, Jean-Louis ULg; Bastings, Eric; Lenaerts, Marc ULg et al

in Revue Médicale de Liège (1994), 49(11), 603-10

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See detailTechniques moleculaires de detection et d'identification des agents phytopathogenes.
Lepoivre, Philippe ULg; Kummert, J.; Colinet, D. et al

in Cahiers Agricultures (1994), 3(4),

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See detailApprendre, ou se mettre en projet ? Réflexions au départ d'une expérience de pédagogie du projet en classe du secondaire
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1994), 44e année(n°1), 5-17

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See detailAN IMPROVED ONE-POINT INTEGRATION METHOD FOR LARGE-STRAIN ELASTOPLASTIC ANALYSIS
Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in Computer Methods in Applied Mechanics & Engineering (1994), 118(1-2), 163-177

In this paper, we present a new one-point integration method generalizing Flanagan and Belytschko's method (Internat. J. Numer. Methods Engrg. 17 (1981) 679-706) and a modification of Belytschko and ... [more ▼]

In this paper, we present a new one-point integration method generalizing Flanagan and Belytschko's method (Internat. J. Numer. Methods Engrg. 17 (1981) 679-706) and a modification of Belytschko and Bindeman's method (Comput. Methods Appl. Mech. Engrg. 88 (1991) 311-340), both in the frame of large deformation elastoplastic analysis. These stabilization methods are combined with the radial return method used to integrate the constitutive law. Plane strain problems are first considered, and the method is then generalized to axisymmetrical situations. The explicit time integration scheme with its critical timestep is also considered. A few examples are presented that show the great time savings that can be obtained with reduced integration without any loss of accuracy, and even with a gain in the solution quality, since the underintegrated elements prove to be 'flexurally superconvergent'. [less ▲]

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See detailAgglomérations morphologiques et fonctionnelles, l’apport de la télédétection urbaine
Donnay, Jean-Paul ULg

in Acta Geographica Lovaniensia (1994), 34

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See detailThe experience of the CHU Liege with conservative surgery in the management of upper urinary tract tumors.
Bouffioux, Christian ULg; Andrianne, Robert ULg; Bonnet, Pierre ULg et al

in Acta Urologica Belgica (1994), 62(4), 39-43

A review of 20 cases of conservative surgery for urothelial tumors of the upper tract is presented. The morbidity is limited; the recurrence rate is around 15% in the ipsilateral urinary tract with a mean ... [more ▼]

A review of 20 cases of conservative surgery for urothelial tumors of the upper tract is presented. The morbidity is limited; the recurrence rate is around 15% in the ipsilateral urinary tract with a mean follow up of 41 months. Conservative surgery does not seem to carry a higher fatal risk as compared to more radical surgery. It has indications in some cases which are defined. [less ▲]

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See detailCharacterization of a single prolactin (PRL) receptor in tilapia (Oreochromis niloticus) which binds both PRLI and PRLII
Auperin, B.; Rentier-Delrue, Françoise ULg; Martial, Joseph ULg et al

in Journal of Molecular Endocrinology (1994), 13(3), 241-51

In tilapia, there are two forms of prolactin (PRL) whose effects on sodium and chloride movements differ and depend on the living environment of the fish. To see whether different receptors or the same ... [more ▼]

In tilapia, there are two forms of prolactin (PRL) whose effects on sodium and chloride movements differ and depend on the living environment of the fish. To see whether different receptors or the same receptor mediates these different effects, we have characterized the specific binding of both forms of tilapia (ti)PRL in two osmoregulatory organs, the gill and kidney. Two recombinant tiPRLs were used for this analysis. The recombinant hormones had the same properties as the native hormones in a tilapia gill radioreceptor assay. Specific binding to gill and kidney membranes was increased by optimizing the quality of the tissue preparations (physiological state of fish, membrane preparation) and the incubation conditions (pH, salt concentrations, temperature, time). Under these optimized conditions, we detected only one class of high affinity PRL receptor in gill and kidney. Its binding affinity was higher for tiPRLI than for tiPRLII in both gill and kidney (for tiPRLI the respective affinity values were 2.9 and 2.3 x 10(10) per M, for tiPRLII they were 1.9 and 0.5 x 10(10) per M). In competition studies, tiPRLI was more potent, followed by tiPRLII and ovine (o)PRL. tiGH and oGH did not significantly displace either tiPRL. The receptor we have characterized thus recognizes quite specifically both tiPRLs. [less ▲]

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See detailL'identité wallonne saisie par l'enquête : une approche constructiviste de l'identité collective
Jacquemain, Marc ULg; Vandekeere, Michel; Doutrelepont, René

in Res Publica (1994), 26

The paper shows how a constructivist approach of collective identity makes sense of the use of survey data to approach regional walloon identity

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See detailEffect of dopamine and baclofen on N-methyl-D-aspartate-induced burst firing in rat ventral tegmental neurons.
Seutin, Vincent ULg; Johnson, S. W.; North, R. A.

in Neuroscience (1994), 58(1), 201-6

Intracellular microelectrode recordings were made from dopamine-containing neurons of the ventral tegmental area or substantia nigra zona compacta in rat brain slices in vitro. The firing pattern of the ... [more ▼]

Intracellular microelectrode recordings were made from dopamine-containing neurons of the ventral tegmental area or substantia nigra zona compacta in rat brain slices in vitro. The firing pattern of the neurons was switched from a tonic, single-spike pattern to a burst firing mode by adding N-methyl-D-aspartate (20 microM) to the superfusing solution; after adding tetrodotoxin the membrane potential underwent rhythmical oscillations of 20-40 mV at 0.5-2 Hz. Baclofen (1 microM) and dopamine (30 microM) hyperpolarized the neurons; when the potential was restored to its original level, the oscillations of potential and/or burst firing were not observed, but the tonic firing pattern was restored. These effects of baclofen and dopamine were prevented by barium (1 mM), which also prevented the membrane hyperpolarization. Oscillations of membrane current of a similar frequency were observed when the somatic membrane was voltage-clamped at -60 mV; these were also blocked by barium (1 mM). It is concluded that the oscillations in membrane potential observed with N-methyl-D-aspartate are generated predominantly at a dendritic location which is not voltage-clamped with an electrode at the soma. Baclofen and dopamine inhibit the oscillations by increasing the potassium conductance and hyperpolarizing the dendrites. [less ▲]

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See detailQue retenir d’une expérience d’éducation physique quotidienne dans le cadre d’une rénovation de l’enseignement fondamental?
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Revue de l'Education Physique (1994), 34(2-3), 117-120

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples ... [more ▼]

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples éclairages. Par les personnes auxquelles il s'adresse, par la diversité de ces effets et par l'organisation qu'il requiert, par la nécessité de mettre en évidence les relations de causalité, il a nécessité une méthodologie d'évaluation multidimensionnelle. [less ▲]

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See detail"Des biet ou lombardeau": La langue d'un écrivant belgoroman du début du 17e siècle
Boutier, Marie-Guy ULg; Chambon, Jean-Pierre

in Revue de Linguistique Romane (1994), 58

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See detailThe treatment of amiodarone-induced hyperthyroidism. Is there a place for surgery?
Meurisse, Michel ULg; Detroz, Bernard ULg; Messens, D. et al

in Acta Chirurgica Belgica (1994), 94(1), 36-41

In many instances amiodarone-induced hyperthyroidism has been reported as mild, thyroid functions returning to normal after discontinuation of the drug. Nevertheless, life-threatening amiodarone-induced ... [more ▼]

In many instances amiodarone-induced hyperthyroidism has been reported as mild, thyroid functions returning to normal after discontinuation of the drug. Nevertheless, life-threatening amiodarone-induced thyrotoxicosis has also been described. Conventional treatments such as with antithyroid drugs (Thionamide) and corticosteroids are essentially ineffective or fail to stop the dramatic course of the thyroid crisis. This limited efficacy of medical therapy, particularly in patients with previously--neglected or unknown--thyroid disease, prompted us to intervene surgically. We report a series of six patients who underwent total or nearly total thyroidectomy as first line therapy for four of them. Surgery resulted in rapid resolution of thyrotoxicosis with an uneventful postoperative course. This approach has the advantage of immediate and safe efficacy, low risk of relapse and finally, appears to be the only antithyroid treatment that permits continued therapy with amiodarone. [less ▲]

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See detailPretreatment minimal staging for non-small cell lung cancer: an updated consensus report
Goldstraw; Rocmansb; Ball et al

in Lung Cancer (1994), 11(supp 3), 1-4

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See detailLe rêve du neurobiologiste
Gauthier, Jean-Marie ULg

in Revue Belge de Psychanalyse (1994), 25

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See detailLa régionalisation du droit pénal international
Flore, Daniel ULg; Thomas, F.

in Revue internationale de droit pénal (1994)

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See detailLa métropolisation, une nouvelle donne
Merenne-Schoumaker, Bernadette ULg

in Acta Geographica Lovaniensia (1994), (34), 165-174

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has ... [more ▼]

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has tackled successively four points: the concepts of metropolis and metropolization, the metropolization process, the metropolization and the city systems, the metropolization in Europe and Belgium. [less ▲]

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See detailPsychophysiological correlates of suicidal behavior in depression. A preliminary study.
Hansenne, Michel ULg; Pitchot, William ULg; Gonzalez Moreno, A. et al

in Neuropsychobiology (1994), 30(1), 1-3

P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results show a significant reduction of both P300 and CNV in patients ... [more ▼]

P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results show a significant reduction of both P300 and CNV in patients who had attempted suicide as compared with patients who had not. Moreover, a significant correlation was found between the suicidal risk scale and CNV amplitude. Psychophysiological and biochemical implications are discussed. [less ▲]

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See detailEvidence that two tilapia (Oreochromis niloticus) prolactins have different osmoregulatory functions during adaptation to a hyperosmotic environment
Auperin, B.; Rentier-Delrue, Françoise ULg; Martial, Joseph ULg et al

in Journal of Molecular Endocrinology (1994), 12(1), 13-24

Two forms of prolactin (tiPRLI and tiPRLII), with only 69% sequence identity, have been previously described in the cichlid fish tilapia (Oreochromis species). In the present study we have attempted to ... [more ▼]

Two forms of prolactin (tiPRLI and tiPRLII), with only 69% sequence identity, have been previously described in the cichlid fish tilapia (Oreochromis species). In the present study we have attempted to investigate the biological activity of these two prolactin forms during adaptation to a hyperosmotic environment. For this purpose, we have developed two highly sensitive (sensitivity: 0.05 ng/ml) and specific (cross-reactivity < 0.04%) radioimmunoassays for tiPRLI and tiPRLII, using recombinant hormones. When fish were directly transferred from fresh to brackish water, the measured levels of plasma tiPRLI and tiPRLII dropped abruptly until 12 h after transfer. Thereafter, plasma tiPRLII remained stable (around 0.5 ng/ml) until the end of the experiment, whereas plasma tiPRLI continued to decrease to undetectable levels. These different patterns of change are reflected in the calculated ratio of plasma tiPRLII to tiPRLI, which increased from 2-3 in fresh water-adapted fish to over 10 in fish which had spent 3 days or more in brackish water. The pituitary contents of tiPRLI and tiPRLII varied in a qualitatively similar fashion after transfer to brackish water. The tiPRLI content dropped continuously after 12 h, reaching one-twelfth of its initial level after 2 weeks. The pituitary tiPRLII content, on the other hand, did not decrease significantly until day 7, and after a 2-week exposure to brackish water it had only decreased by 50%. When injected into tilapia adapted to brackish water, both ovine prolactin and recombinant tiPRLI induced a clear dose-dependent ion-retaining effect. In contrast, the effect induced by tiPRLII treatment was markedly smaller and not dose-dependent. Northern blot analysis of tiPRL mRNAs using either a tiPRLI or a tiPRLII cDNA probe indicated the presence of two mRNAs differing in size: a 1.7 kb mRNA coding for tiPRLI and a 1.3 kb mRNA coding for tiPRLII. After transfer to brackish water, levels of the two mRNAs decreased similarly. The present study indicates that, in O. niloticus, the two forms of prolactin have different osmoregulatory roles during adaptation to brackish water. Accordingly, their synthesis are differentially regulated after transfer to a hyperosmotic environment, presumably at a post-transcriptional level. [less ▲]

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See detailEffects of immunization against somatostatin on growth performances and growth hormone, insulin-like growth factor I and insulin plasma levels in young animals
Renaville, Robert ULg; Fernadez, J. J.; Sneyers, Myriam et al

in Zootecnica e Nutrizione Animale (1994), 20

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See detailOptimisation du plan parcellaire d'une exploitation agricole: une application de la theorie des graphes.
Dupont, Pascal ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(3),

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See detailIsolation of the missing 5-end of the encoding region of the bovine leukemia virus cell receptor gene.
Ban, J.; Truong, A. T.; Horion, B. et al

in Archives of Virology (1994), 138(3-4),

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See detailLes indices de déformation plio-quaternaire de la bordure occidentale du bassin des Iullemenden dans la région de Niamey (Niger).
Vicat, Jean-Paul; Léger, Jean-Marc; AHMED, Y et al

in Revue de Géographie Alpine (1994), 5

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See detailEtude des relations entre les microstructures obtenues par vieillissement isotherme et le comportement mécanique (fatigue, résilience) dans des alliages Zn-Al et Zn-Al-Cu
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Wegria, J.

in Revue de Métallurgie [=Revue de Métallurgie. Cahiers d'Informations Techniques] (1994), 91[5]

L’article présenté établit une corrélation entre le comportement mécanique (fluage, résilience) et les microstructures qui apparaissent au cours d’un traitement thermique isotherme (100 ou 250 °C) dans ... [more ▼]

L’article présenté établit une corrélation entre le comportement mécanique (fluage, résilience) et les microstructures qui apparaissent au cours d’un traitement thermique isotherme (100 ou 250 °C) dans des alliages Zn-Al et Zn-Al-Cu1. Le but est de mettre en évidence l’intérêt pratique des modifications structurales obtenues. On observe un meilleur résultat pour des échantillons vieillis pendant une semaine environ. La température de traitement la plus favorable est 250 °C. De plus, les alliages contenant du cuivre possèdent un meilleur comportement que les alliages binaires Zn-Al. [less ▲]

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See detailAnalysis by in Situ Hybridization of Cytokine Mrnas Expression in Thymic Nurse Cells
Deman, J.; Humblet, Chantal ULg; Martin, M. T. et al

in Advances in Experimental Medicine and Biology (1994), 355

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See detailL'entérotoxémie bovine en Belgique. I. Introduction et contexte bibliographique.
Manteca, C.; Daube, Georges ULg

in Annales de Médecine Vétérinaire (1994), 138

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