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See detailRegulation Of The Beta-Lactamase Blal Of Streptomyces-Cacaoi - The Product Of The Blab Regulatory Gene Is An Internal Membrane-Bound Protein
Magdalena, J.; Joris, Bernard ULg; Vanbeeumen, J. et al

in Biochemical Journal (1995), 311

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open ... [more ▼]

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open reading frames, ORF1 (blaA) and ORF2 (blaB) [Lenzini, Magdalena, Fraipont, Joris, Matagne and Dusart (1992) Mol. Gen. Genet. 235, 41-48]. BlaA belongs to the LysR family of transcription activators, whereas BlaB shares some features with the penicillin-recognizing proteins. BlaB has now been overexpressed in Escherichia coli, purified and used for antibody preparation. Immunoblotting of cell-fractionated materials from S. cacaoi showed that BlaB is attached to the internal face of the cytoplasmic membrane. It could not be released by high salt concentrations or EDTA, but only by protease treatment. Under the assay conditions, BlaB did not act as a penicillin-binding protein, a beta-lactamase, a D-amino-peptidase or a target in a phosphorylation step. [less ▲]

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See detailLes futurs enseignants se sentent-ils une responsabilité vis-à-vis de l'échec scolaire ?
Beckers, Jacqueline ULg

in Education et Recherche (1995), 17(3),

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See detailFra Stein til Waldrop: sprogdigtningen og de nye prosadigtere
Delville, Michel ULg; Schatz-Jakobsen, Claus

in Den Blå Port: Tidsskrift for Litteratur (1995)

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See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

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See detailIdentification of structural determinants controlling human and mouse stromelysin-3 proteolytic activities
Noël, Agnès ULg; Santavicca, M.; Stoll, I. et al

in Journal of Biological Chemistry (1995), 270

Matrix metalloproteinases (matrixins) constitute a group of extracellular proteinases belonging to the metzincin superfamily. They are involved in both physiological and pathological tissue remodeling ... [more ▼]

Matrix metalloproteinases (matrixins) constitute a group of extracellular proteinases belonging to the metzincin superfamily. They are involved in both physiological and pathological tissue remodeling processes, including those associated with cancer progression. Stromelysin-3, which is expressed in most invasive human carcinomas, is a matrix metalloproteinase with unusual functional properties. In particular, its mature form does not cleave any of the major extracellular matrix components. To define critical structural determinants involved in controlling stromelysin-3 proteolytic activity, we have used site-directed mutagenesis. We show that the deletion of at least 175 C-terminal amino-acids is sufficient to endow mouse stromelysin-3 with activities against casein, laminin, and type IV collagen. In the case of the human enzyme, however, a further and single Ala-235 Pro substitution is necessary to observe similar activities. Ala-235, which characterizes human stromelysin-3 among matrixins, is located immediately after the C terminus of the “Met-turn,” which forms a hydrophobic basis for the catalytic zinc atom in the metzincin family. We conclude that human stromelysin-3 has gained specific functional properties during evolution by amino acid substitution in the catalytic zinc environment, and that it represents an attractive target for specific inhibitors that may be used to prevent cancer progression. [less ▲]

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See detailTransgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
Plumier, Jean-Christophe ULg; Ross, B.; Currie, R. W. et al

in Journal of Clinical Investigation (1995), 95(4), 1854-60

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock ... [more ▼]

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock proteins, the amount of the inducible heat shock protein 70 (HSP70) and the level of myocardial protection. The inducible HSP70 has also been shown to be protective in transfected myogenic cells. Here we examined the role of human inducible HSP70 in transgenic mouse hearts. Overexpression of the human HSP70 does not appear to affect normal protein synthesis or the stress response in transgenic mice compared with nontransgenic mice. After 30 min of ischemia, upon reperfusion, transgenic hearts versus nontransgenic hearts showed significantly improved recovery of contractile force (0.35 +/- 0.08 versus 0.16 +/- 0.05 g, respectively, P < 0.05), rate of contraction, and rate of relaxation. Creatine kinase, an indicator of cellular injury, was released at a high level (67.7 +/- 23.0 U/ml) upon reperfusion from nontransgenic hearts, but not transgenic hearts (1.6 +/- 0.8 U/ml). We conclude that high level constitutive expression of the human inducible HSP70 plays a direct role in the protection of the myocardium from ischemia and reperfusion injury. [less ▲]

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See detailEscape into Innocence: Ian McEwan and the Nightmare of History
Delrez, Marc ULg

in Ariel : A Review of International English Literature (1995), 26(2), 7-23

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See detailHyperfine structure of infrared vanadium lines
Palmeri, P.; Biémont, Emile ULg; Aboussaïd, A. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

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See detailDevelopmental disturbance of access to biographical information and people's names: A single-case study
Van der Linden, Martial ULg; Brédart, Serge ULg; Schweich, M.

in Journal of the International Neuropsychological Society (1995), 1(6), 589-595

The paper describes the case of a person (GB) without any clinical evidence of cerebral disease who showed a specific impairment in the retrieval of biographical information, including names, about famous ... [more ▼]

The paper describes the case of a person (GB) without any clinical evidence of cerebral disease who showed a specific impairment in the retrieval of biographical information, including names, about famous people. This deficit appeared while GB scored normally in different long-term memory tasks, and in object naming tasks. Moreover, he showed no impairment in the structural encoding and the recognition of faces. His specific impairment is interpreted both in terms of Bruce and Young's (1986) functional model of person recognition and in terms of the more recent Burton et al. (1990) interactive activation version of the Bruce and Young model. [less ▲]

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See detailThe Kozani-Grevena (Greece) earthquake of May 13, 1995, Ms=6.6, Preliminary results of a field multidisciplinary survey
Hatzfeld, D.; Nord, J.; Paul, A. et al

in Seismological Research Letters (1995), 66

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See detailLichens and lichenicolous fungi on Laing Island (Papua New Guinea)
Aptroot, André; Diederich, Paul; Sérusiaux, Emmanuël ULg et al

in Bibliotheca Lichenologica (1995), 57

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See detailHydroxychloroquine (Plaquenil) for recurrence prevention of Crohn's disease after curative surgery.
Louis, Edouard ULg; Belaiche, Jacques ULg

in Gastroentérologie Clinique et Biologique (1995), 19(2), 233-4

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See detailImproving the action of insulin.
Lefebvre, Pierre ULg; Scheen, André ULg

in Clinical & Investigative Medicine = Médecine Clinique et Experimentale (1995), 18(4), 340-7

Improving the action of insulin is a relatively new concept in diabetes management. Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by ... [more ▼]

Improving the action of insulin is a relatively new concept in diabetes management. Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by correcting a subclinical magnesium deficiency. Pharmacological means of improving insulin action include metformin, antiobesity serotoninergic agents and, possibly, benfluorex. New compounds aiming at improving the action of insulin are in development and include thiazolidinedione derivatives (known as "insulin sensitizers"), inhibitors of adipose tissue lipolysis (e.g. acipimox), and inhibitors of free fatty acid oxidation (e.g. etomoxir). Avoidance of drugs that reduce insulin sensitivity, such as beta blockers and thiazide diuretics, is recommended. Finally, cigarette smoking is associated with resistance to insulin but it remains to be demonstrated that cessation of cigarette smoking does in fact increase sensitivity to insulin. [less ▲]

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See detailFactors regulating megakaryocyte progenitor commitment to polyploidization.
Paulus, Jean-Michel ULg; Grosdent, J C; Prenant, M et al

in Comptes Rendus de l'Académie des Sciences. Série III. Sciences de la Vie (1995), 318(3), 381-6

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms ... [more ▼]

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms of megakaryocytes determined by microphotometric or flow cytometric measurements of megakaryocyte DNA have generally been used. However these techniques provide no information on the rate of commitment of CFU-MKC to polyploidy. Using a technique of clonal analysis determining the distributions of the number of doublings (NbD) undergone by CFU-MKC before committing to polyploidization, the polyploidization probability of CFU-MKC could be derived. This probability was found to be a constant independent from CFU-MKC mitotic history, since NbD distributions are exponential functions characterized by a constant rate of decay per doubling. By studying the effects of growth factors on polyploidization probability, it was also shown that: (1) this parameter is negatively regulated by growth factors contained in poke-weed or WEHI conditioned media, as well as by erythropoietin; (2) commitment to polyploidization does not require prior CFU-MKC division; (3) bipotent erythroid-megakaryocyte progenitors have a lower polyploidization probability than CFU-MKC; (4) determination of polyploidization probability reflects the activity of growth factors with greater accuracy than megakaryocyte colony count. [less ▲]

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See detailLa grammaire au secours de la datation des textes
Winand, Jean ULg

in Revue d'Egyptologie (1995), 46

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See detail3-Methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailA magnetic resonance imaging approach for the diagnosis of a triplet cornual pregnancy.
Bassil, Salim; Gordts, Stéphane; NISOLLE, Michelle ULg et al

in Fertility and Sterility (1995), 64(5), 1029-31

Objectives: To describe a rare case of triplet cornual pregnancy after IVF-ET and to assess the role of magnetic resonance imaging (MRI) for early diagnosis. DESIGN: Case report. SETTING: Infertility and ... [more ▼]

Objectives: To describe a rare case of triplet cornual pregnancy after IVF-ET and to assess the role of magnetic resonance imaging (MRI) for early diagnosis. DESIGN: Case report. SETTING: Infertility and IVF Unit, in an university medical center. PATIENT: A 31-year-old healthy patient with a 3-year history of primary male infertility. INTERVENTION: Standard IVF-ET treatment cycle, using a GnRH-agonist (long protocol) and hMG for ovarian stimulation. RESULTS: A cornual triplet pregnancy is described with the approach for the diagnosis. Magnetic resonance imaging was complementary to endovaginal sonography for early diagnosis and permitted a timed conservative management. CONCLUSIONS: When transvaginal ultrasound findings did not provide an accurate location of the pregnancy, MRI was indicated to confirm the diagnosis. [less ▲]

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See detailINVESTIGATION OF THE ELECTRICAL-RESISTIVITY BEHAVIOR BETWEEN THE KOSTERLITZ-THOULESS TEMPERATURE AND THE GINZBURG-LANDAU TEMPERATURE IN SPRAY-DRIED BULK BI2SR2CACU2O8+D - THE ROLE OF 2-DIMENSIONAL FLUCTUATIONS AND DEFECTS
Ausloos, Marcel ULg; Bougrine, Hassan ULg; DUVIGNEAUD, P. H. et al

in Physica C (1995), 251(3-4), 337-347

The resistive transition R(T) between the Kosterlitz-Thouless temperature and the Ginzburg-Landau temperature was studied in spray-dried bulk Bi2Sr2CaCu2O8+d superconductors for a magnetic-field range ... [more ▼]

The resistive transition R(T) between the Kosterlitz-Thouless temperature and the Ginzburg-Landau temperature was studied in spray-dried bulk Bi2Sr2CaCu2O8+d superconductors for a magnetic-field range between 0 and 0.3 T. The samples were prepared by the spray-drying technique with Bi2+xSr2-x-yCa2+yCu2O8+d for x = y = 0.05 or 0.1 as a starting composition here. The data analysis was performed assuming various resistive laws previously proposed. When numerically analyzed in terms of a two-dimensional Kosterlitz-Thouless theory the results lead to remarkable quantitative agreement. This implies that the R(T) behavior can be described within a picture of a highly two-dimensional behavior of macroscopic fluctuations of vortex-antivortex depairing type. The role of defects or inhomogeneities in the resistive behavior is outlined. [less ▲]

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See detailTreatment of Bone in Elderly Subjects: Calcium, Vitamin D, Fluor, Bisphosphonates, Calcitonin
Reginster, Jean-Yves ULg

in Hormone Research (1995), 43(1-3), 83-8

Several approaches may be suggested for prevention or treatment of senile osteoporosis. In elderly patients, an association of calcium and vitamin D supplementation has been shown to reduce nonvertebral ... [more ▼]

Several approaches may be suggested for prevention or treatment of senile osteoporosis. In elderly patients, an association of calcium and vitamin D supplementation has been shown to reduce nonvertebral fractures up to 40% over an 18-month period. Calcitonin, given parenterally or nasally, may prevent further bone loss and has been reported to significantly decrease vertebral and hip fractures. This hormone also possesses an important analgesic effect. Fluoride salts are the most effective way to significantly increase bone mass, mainly at the trabecular site. The optimal doses and regimens remain to be clearly established. The use of new formulations like sodium monofluorophosphate are likely to facilitate the search of the optimal therapeutic window. Bisphosphonates are potent inhibitors of bone resorption. They have been shown to significantly increase trabecular bone mass without impairment of cortical bone. Their use may be associated with a significant decrease in vertebral fractures, mainly in patients with severe osteoporosis. The new, second and third generation of bisphosphonates (tiludronate, risedronate, alendronate) look extremely promising but their widespread use will only be possible after a confirmation of the absence of a deleterious effect on bone quality (alendronate) and after demonstration of a reduction in vertebral and/or hip fractures following a prolonged use. [less ▲]

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See detailAutovidéoscopie et formation des enseignants: les techniques d'analyse de gestes
Cloes, Marc ULg; Piéron, Maurice

in Eduquer et former. Théories et pratiques (1995), 3/4

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation ... [more ▼]

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation des techniques d'analyse de gestes sur vidéo et d'enseignement simulé. L'articulation de l'analyse avec la littérature scientifique du domaine laisse une grande liberté de transposition vers d'autres champs d'application. [less ▲]

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See detailVaux-et-Borset : site néolithique, campagne de fouilles 1994
Caspar, Jean-Paul; Delye, Emmanuel ULg; Rochus, Noémie et al

in Chronique de l'Archéologie Wallonne (1995), 3

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See detailANISOTROPY OF THE MIXED-STATE IN TEXTURED PB-FREE BI-2223 SUPERCONDUCTOR - ELECTRICAL-RESISTIVITY, SEEBECK AND NERNST EFFECTS
PEKALA, M.; Bougrine, Hassan ULg; LADA, T. et al

in Superconductor Science & Technology (1995), 8(9), 726-739

Anisotropy of transport entropy and of Hall angle are reported for the first time through various electrical and thermal transport properties, such as the electric resistivity and the Seebeck and the ... [more ▼]

Anisotropy of transport entropy and of Hall angle are reported for the first time through various electrical and thermal transport properties, such as the electric resistivity and the Seebeck and the Nernst effects (in the presence of a magnetic field ranging between 0 and 4 T), measured for a Pb-free textured Bi-2223 system. The field and temperature influence in the mixed state region is reported only for the H parallel to a and H parallel to c cases and the temperature gradient applied along the b direction. A much stronger influence of magnetic field along the c than the a axis is demonstrated. The relative evolution of the so-called 'excess transport effects' is discussed. We show the laws relating the respective losses to the applied magnetic field. This leads us to the understanding that anisotropic vortex kinetics exist in these systems. We consequently propose two original routes of theoretical investigations to be considered for the calculation of Nernst and TEP effects in a field, in particular to consider a vortex-carrier drag phenomenon. [less ▲]

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See detailTRANSPORT STUDY OF BA-DEFICIENT THIN-FILM Y123 SUPERCONDUCTORS ENRICHED WITH NA
PEKALA, M.; Bougrine, Hassan ULg; AZOULAY, J. et al

in Superconductor Science & Technology (1995), 8(8), 660-666

Nominal Y0.3Ba0.6Na0.1CuO3-delta thin films were prepared with small grains having an orientation of the c axis perpendicular to the MgO substrate. The electrical resistivity and the thermoelectric power ... [more ▼]

Nominal Y0.3Ba0.6Na0.1CuO3-delta thin films were prepared with small grains having an orientation of the c axis perpendicular to the MgO substrate. The electrical resistivity and the thermoelectric power in the absence and in the presence of a magnetic field are reported. The magnetic field dependence of the irreversibility line is discussed. The role of the field for disentangling intragrain and intergrain effects in both coefficients is emphasized. [less ▲]

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See detailELECTRICAL AND THERMOMAGNETIC EFFECTS IN BI1.7PB0.3SR2CA2CU3O10 SUPERCONDUCTING CERAMICS
Pekala, M.; Bougrine, Hassan ULg; Ausloos, Marcel ULg

in Journal of Physics : Condensed Matter (1995), 7(28), 5607-5621

We report the electrical resistivity and thermoelectric power of polycrystalline Pb-doped Pi 2:2:2:3 superconductors. In particular the mixed-state properties are investigated by measuring the ... [more ▼]

We report the electrical resistivity and thermoelectric power of polycrystalline Pb-doped Pi 2:2:2:3 superconductors. In particular the mixed-state properties are investigated by measuring the longitudinal and transverse (Nernst) thermoelectric power. For the first time we show the presence of hysteresis in a high magnetic field for the Nernst effect. We discuss the variation with magnetic field in the properties with respect to the zero-field case and show the power-law behaviour with exponents depending on the transport quantity. We extract 'derived properties' such as the effective mass, the transport entropy, the Ginzburg-Landau parameter, the thermal Hall angle and the activation energy and compare them with previous data on related systems. [less ▲]

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See detailReaction Window in the single-electron capture by Ammonia Dications.
Leyh, Bernard ULg; Hoxha, Antuan

in Chemical Physics (1995), 192

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC ... [more ▼]

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC cross-section goes through a maximum within a reaction window centered at an exothermicity of approximately 4.5 eV. This corresponds to a target-projectile distance for the charge transfer of about 3.2 Angstöm. The average internal energy of NH3+-ions resulting from SEC has been obtained both via translational energy gain measurements and via an analysis of the daughter ion spectra. The agreement between both methods is satisfactory and shows that the lower the ionisation energy of the target, the more probable the excitation of NH3+ to the A2E state. With benzene (ionization energy=9.25 eV) as the target gas, however, the excess energy is converted partly to internal energy of C6H6+, leading most probably to the D2B2u, E2B1u and F2A1g states of C6H6+. A model based on the Landau-Zener non-adiabatic formalism, including one entrance channel (NH32++G) and two exit channels (NH3+ X2A"2+G+ and NH3+ A2E+G+) accounts qualitatively for the observed results in the case of exothermic single-electron capture. This model is not appropriate for slightly exothermic and endothermic charge transfer, i.e., in the present case, for the Ne and He target gases. [less ▲]

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See detailRadiochirurgie et radiothérapie stéréotaxique
Coucke, Philippe ULg; FANKHAUSER

in Médecine et Hygiène (1995), 53(2088), 2002--2009

La radiochirurgie, appelée radiothérapie stéréotaxique lorsqu'il s'agit d'un traitement fractionné, s'effectue en Suisse depuis 1993, soit par accélérateur linéaire modifié, soit par Gamma Knife. Par ... [more ▼]

La radiochirurgie, appelée radiothérapie stéréotaxique lorsqu'il s'agit d'un traitement fractionné, s'effectue en Suisse depuis 1993, soit par accélérateur linéaire modifié, soit par Gamma Knife. Par cette technique on arrive à administrer une dose élevée de radiations à des lésions intracrâniennes circonscrites d'une taille de 3 à 4 cm au maximum, tout en ménageant les tissus normaux avoisinants. Lorsque les lésions sont plus grandes, mal délimitées, ou de forme irrégulière, c'est la radiothérapie conventionnelle et conformationnelle qui offre une meilleure répartition des doses. Les principales lésions considérées pour la radiochirurgie sont les malformations artérioveineuses, les métastases cérébrales solitaires, les méningiomes de la base, les schwannomes vestibulaires et certaines récidives focales de gliomes. [less ▲]

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See detailAneurysms of the abdominal aorta: familial and genetic aspects in three hundred thirteen pedigrees.
VERLOES, Alain ULg; SakalihasanN, Natzi ULg; Koulischer, Lucien ULg et al

in Journal of Vascular Surgery (1995), 21(4), 646-55

PURPOSE: Familial clustering of abdominal aortic aneurysm was first noticed in 1977. METHODS: Through questionnaire and phone inquiry, familial data on 324 probands with abdominal aortic aneurysms allowed ... [more ▼]

PURPOSE: Familial clustering of abdominal aortic aneurysm was first noticed in 1977. METHODS: Through questionnaire and phone inquiry, familial data on 324 probands with abdominal aortic aneurysms allowed the establishment of 313 multigenerational pedigrees including 39 with multiple affected patients. RESULTS: There were 276 sporadic cases (264 men, 12 women); 81 cases belonged to multiplex pedigrees (76 men; 5 women). We compared familial and sporadic male cases; the ages at diagnosis were 64.1 +/- 7.9 years and 66.0 +/- 7.3 years (p < 0.05), respectively, the ages at rupture were 65.4 +/- 6.6 years and 75.2 +/- 8.6 years (p < 0.001), and the rupture rate was 32.4% and 8.7% (p < 0.001). Survival curves were computed. Relative risk for male siblings of a male patient was 18. We performed a segregation analysis with the mixed model, the most likely explanation for occurrence of abdominal aortic aneurysm in our families was a single gene effect showing dominant inheritance. The frequency of the morbid allele was 1:250, and its age-related penetrance was not higher than 0.4. CONCLUSION: This analysis indicates the preeminence of genetic factors on multifactorial/environmental effects of the pathogenesis of abdominal aortic aneurysm. [less ▲]

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See detailExpertise scientifique et action publique : le cas du changement climatique dans trois pays européens
Mormont, Marc ULg; Dasnoy, Christine ULg

in Natures Sciences Sociétés (1995), 3(&), 16-25

L'expertise scientifique du changement climatique fait l'objet d'une réception très différente en France, en Allemagne et en Belgique. cet état de fait semble lié à la fois à des configurations politiques ... [more ▼]

L'expertise scientifique du changement climatique fait l'objet d'une réception très différente en France, en Allemagne et en Belgique. cet état de fait semble lié à la fois à des configurations politiques différentes, à des procédures spécifiques mais aussi aux stratégies des scientifiques lesquelles dépendent de leur anticipation de cette réception. Cette stratégie des "sources" d'information ne laisse pas de poser des questions sur l'expertise. [less ▲]

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See detailEndogenous reproductive hormones and nocturnal rhythms in partner preference and sexual behavior of ATD-treated male rats.
Bakker, Julie ULg; van Ophemert, J.; Timmerman, M. A. et al

in Neuroendocrinology (1995), 62(4), 396-405

Male rats received subcutaneously silastic capsules, containing the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD), shortly after birth. Control males were given silastic capsules containing ... [more ▼]

Male rats received subcutaneously silastic capsules, containing the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD), shortly after birth. Control males were given silastic capsules containing cholesterol. The capsules were removed at the age of 21 days. In adulthood, blood serum was collected early and late in the dark phase of the light/dark cycle (experiment I). Testosterone and luteinizing hormone and follicle stimulating hormone (FSH) fluctuated nocturnally, both in ATD and control males, with highest levels late in the dark phase. FSH levels were significantly higher in ATD males. Nocturnal levels of inhibin, a selective suppressor of pituitary FSH secretion, also fluctuated in both ATD and control males, with lowest levels late in the dark phase. In experiment II, ATD and control males were tested for partner preference behavior in a three-compartment box (choice: sexually active male vs. estrous female) early and late in the dark phase. When gonadally intact, ATD males, but not controls, showed a clear nocturnal rhythmicity in partner preference behavior and sexual behavior. Early in the dark phase, such ATD males preferred the vicinity of and interaction with a sexually active male. Late in the dark phase, this preference for the active male shifted to a preference for the estrous female. Control males preferred the estrous female. After castration and subsequent treatment with testosterone via silastic capsules, which ensured constant blood serum levels, ATD males continued to show their nocturnal rhythms in partner preference behavior and in sexual behavior. Thus, the underlying mechanism of the nocturnal rhythmicity phenomenon is an organizational effect of neonatal ATD treatment rather than an activational effect of fluctuating serum hormone levels. [less ▲]

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See detailLa naissance des cités au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailComment explorer la sensibilite a l'insuline chez l'homme?
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in Annales d'Endocrinologie (1995), 56(5), 523-30

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose ... [more ▼]

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose clamp is the reference method, well validated and easy to interpret, which allows various extensions to the basic experimental procedure in order to obtain more valuable information on the specific effects of insulin on the various aspects of glucose metabolism. However, it is time-consuming and labour-intensive. In contrast, the intravenous glucose tolerance test is easier to perform, but its interpretation is much more difficult and requires a modeling approach called the "minimal model". If the intravenous glucose tolerance test probably represents a good screening test, mainly on a population basis, the glucose clamp still remains the gold standard method to study insulin sensitivity in man. [less ▲]

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See detailEntre sémantique et syntaxe. Pour une classification des lexèmes verbaux en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

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See detailCombined radiotherapy and radioimmotherapy of human colon carcinoma grafted in nude mice.
Buchegger, F; Rojas, A; Delaloye, A et al

in Cancer Research (1995), 55

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were ... [more ▼]

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were selected for being resistant to RIT alone, as is usually the case in the clinical situation. Tumor-bearing mice were treated with a combination of five X-ray fractions over 5 days followed by RIT with two doses of 1.5 mCi 131I-labeled anticarcinoembryonic antigen monoclonal antibody F(ab')2. In Col 12 and LS174T, RIT alone achieved a regrowth delay similar to that of fractionated RT with total doses of 28 and 26 Gy, respectively. In both tumor types, an additive therapeutic effect, measured as increased regrowth delay or local control, was observed when combining RT of different dose levels with RIT. Normal tissue responses were assessed by monitoring acute peak skin reactions and blood cell count. Bone marrow depression for the combination treatment was similar to that of RIT alone; relative to skin, at equitoxic levels, no mice bearing Col 12 tumors were locally controlled with a 32 Gy RT dose alone, while this RT combined with RIT gave a local control of 100%. These studies show a therapeutic benefit when external beam RT is combined with RIT. [less ▲]

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See detailR&D, technological progress and efficiency change in industrial activities
Perelman, Sergio ULg

in Review of Income and Wealth (1995), (41), 349-366

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic ... [more ▼]

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic frontiers and non-parametric production frontiers (DEA). The TFP is decomposed into two components, technological progress and efficiency change, that can also be interpreted as the results of the innovation and catching-up process, respectively. Finally their relationship is tested with a set of potential explanatory variables that includes R&D expenditures, international competition, and structural characteristics. It appears that the distinction between technological and efficiency performances does matter and must be taken into account in the design of industrial policy. [less ▲]

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See detailMolecular description of the interactions of aminoglycoside antibiotics with negatively-charged phospholipids. Theoretical molecular modelling and experimental results.
Mingeot-Leclercq, M. P.; Schanck, A.; Van Bambeke, F. et al

in Pharmacology (1995), 14

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See detailN2-cyano-N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulfonyl]guanidine
Dupont, L.; Masereel, B.; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailLa disparition de l'absorption
Kefer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1995)

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See detailRecent advances in the chemistry of potassium channel openers
Pirotte, Bernard ULg; Fontaine, J.; Lebrun, P.

in Current Medicinal Chemistry (1995), 2

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See detailInverse Modulation of Intraepithelial Langerhans' Cells and Stromal Macrophage/Dendrocyte Populations in Human Papillomavirus-Associated Squamous Intraepithelial Lesions of the Cervix
Al-Saleh, Walid; Delvenne, Philippe ULg; Arrese Estrada, Jorge ULg et al

in Virchows Archiv : An International Journal of Pathology (1995), 427(1), 41-8

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal ... [more ▼]

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal macrophages/dendrocytes by immunohistochemistry using anti-S100, -L1, -CD68 and -factor XIIIa antibodies. Human papillomavirus (HPV) detection was performed in all cases by using first a mixture of DNA probes for 14 HPV types commonly found in anogenital biopsies at low stringency conditions (Tm -40 degrees C) and by reanalyzing the tissues at high stringency (Tm -10 degrees C) with HPV 6/11, 16/18 and 31/33/35 biotinylated probe cocktails and individual digoxigenin-labelled probes. SILs and metaplastic tissues were significantly associated with a depletion of S100-positive intraepithelial Langerhans' cells when compared with normal epithelium. In contrast, there was a significant increase in L1-positive stromal macrophages in SIL biopsies compared with normal or metaplastic cervix. A significantly higher density of CD68-positive macrophages was also observed in high-grade SILs compared with normal or metaplastic biopsies and with low-grade SILs. The density of factor XIIIa-positive dendrocytes was found to be higher in SILs compared with metaplastic tissues and in high-grade SILs when compared with normal cervical biopsies. No specific relationship was found between the densities of these cells and the HPV type detected in SILs separated into low grade and high grade. The significance of this inverse modulation of intraepithelial Langerhans' cells and stromal macrophages/dendrocytes in normal and SIL biopsies is discussed in relation to HPV infection and malignant transformation. [less ▲]

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See detailFast Routine Production of L-[11C-methyl]methionine with Al2O3KF
Schmitz, Frédéric; Plenevaux, Alain ULg; Del-Fiore, Guy et al

in Applied Radiation & Isotopes (1995), 46(9), 893-897

No-carrier-added (nca) L-[11C-methyl]methionine was prepared via the very fast S-alkylation of L-homocysteine adsorbed on AI203/KF with [11C]iodomethane at room temperature in ethanol. The alkylation was ... [more ▼]

No-carrier-added (nca) L-[11C-methyl]methionine was prepared via the very fast S-alkylation of L-homocysteine adsorbed on AI203/KF with [11C]iodomethane at room temperature in ethanol. The alkylation was realized with a radiochemical yield of 94 +/- 4% EOB (n = 20). More than 90% (n = 20) of the precursor L-homocysteine remained adsorbed on the solid support and was eliminated by a simple filtration. After reaction, neither racemization nor by-product were detected. The purification process was thus limited to a C18 Sep-Pak followed by an alumina Sep-Pak. The radiochemical purity measured on the final solution was shown to be > 99%. The only chemical contaminant was L-homocysteine (+ 10 µg). With this new technique, L-[11C-methyl]methionine was ready for injection within 10 min from [11C]CO2 with a specific activity ranging around 37 + 5.6 GBq (1 +/- 0.15 Ci)//tmol EOB. Through this procedure L-[11C-methyl]methionine can be prepared without preparative HPLC purification, This is an important simplification for the fast routine production of one of the most widely used radiopharmaceutical compounds for PET. [less ▲]

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See detailThe role of the Zairian Health Services in the Rwandan refugee crisis.
Porignon, Denis ULg; Noterman, J. P.; Hennart, P. et al

in Disasters (1995), 19(4), 356-60

In July 1994, a stream of Rwandan refugees entered the southern part of North Kivu Region, Zaire. The public health consequences of this crisis for the host population and health services have not been ... [more ▼]

In July 1994, a stream of Rwandan refugees entered the southern part of North Kivu Region, Zaire. The public health consequences of this crisis for the host population and health services have not been analysed up to now. The lack of human and financial resources did not prevent Zairian health structures and personnel from taking care of the many refugees settled outside the camps, following their arrival. The public health consequences of the crisis for the local population should be considered an integral part of the disaster. [less ▲]

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See detailRemote Sensing and Urban Change
Donnay, Jean-Paul ULg; Barnsley, Mike

in GISDATA Newsletter (1995), 6

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See detailComparison of six serum ferritin immunoassays and isoferritin spectrotypes in malignancies
Vernet, M.; Renversez, J. C.; Lasne, Y. et al

in Annales de Biologie Clinique (1995), 53

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See detailNF-kappaB transcription factor activation by hydrogen peroxide can be decreased by 2,3-dihydroxybenzoic acid and its ethylester derivative
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in Archives of Biochemistry & Biophysics (1995)

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See detailA propos des «carnets» d'un pacifiste chrétien : Jean Van Lierde
Jadoulle, Jean-Louis ULg

in Revue d'Histoire Religieuse du Brabant-Wallon (1995), t. IX(fasc. 1), 21-36

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See detailPotentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks
Schoenen, Jean ULg; Wang, W.; Albert, A. et al

in European Journal of Neurology (1995), 2

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See detailBiotinidase Km-variants: detection and detailed biochemical investigations
Suormala, T.; RAMAEKERS, Vincent ULg; Schweitzer, S. et al

in Journal of inherited metabolic disease (1995), 18(6), 689-700

We describe a simple method for the detection of biotinidase Km-variants and detailed biochemical investigations in 5 such patient. They were detected among 103 patients with plasma biotinidase activity ... [more ▼]

We describe a simple method for the detection of biotinidase Km-variants and detailed biochemical investigations in 5 such patient. They were detected among 103 patients with plasma biotinidase activity which ranged from undetectable to 30% of the mean normal value. Two different types of biotinidase Km-variants were found. (1) In 3 infants biotinidase had a single 105-430-fold elevated Km for biocytin. Biotinidase showed very low activities (0.2-4% of the mean normal value) in the routine colorimetric assay and was not functional in vivo. Accordingly, these patients presented with classical clinical illness. (2) In two patients biotinidase showed biphasic kinetics indicating the presence of one component with a normal Km and reduced Vmax (1.7% and 12%), and another with 330- and 59-fold elevated Km, respectively. In these two patients, biotinidase proved to be at least partially functional in vivo. However, the first patient developed severe symptoms and biotin deficiency late, at the age of 10-15 years, and the second had marginal biotin deficiency at the age of 2 years but no clinical symptoms. Comparative studies revealed that both patients had more severe biotin deficiency than age-matched patients with similar levels of residual biotinidase activity and a single normal Km. Therefore, all patients with residual biotinidase activity should be evaluated for the presence of a Km-mutation, since such patients should be treated with biotin. These can easily be detected by including a second substrate concentration (1.5 mmol/L) in the routine colorimetric biotinidase assay which is performed with 0.15 mmol/L biotin. Increased activity with the higher substrate concentration indicates the presence of a Km-mutation. Detailed kinetic studies are needed to evaluate the distinct forms of Km-variants. [less ▲]

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See detailSynthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics
Masereel, B.; Dupont, L.; Laeckmann, D. et al

in European Journal of Medicinal Chemistry (1995), 30

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See detailSerum erythropoietin during autologous bone marrow transplantation: relationship to measures of erythroid activity.
Davies, S. V.; Fegan, C. D.; Kendall, R. et al

in Clinical & Laboratory Haematology (1995), 17(2), 139-44

Marked elevation of serum erythropoietin (sEPO) occurs following high dose chemotherapy for malignant disease. It has been proposed that the subsequent fall in sEPO constitutes a relative erythropoietin ... [more ▼]

Marked elevation of serum erythropoietin (sEPO) occurs following high dose chemotherapy for malignant disease. It has been proposed that the subsequent fall in sEPO constitutes a relative erythropoietin (EPO) deficiency, prompting trials of recombinant EPO to reduce red cell transfusion during chemotherapy. We have investigated these phenomena by serial estimations of reticulocytes and sEPO in 11 autologous marrow transplant recipients. sEPO reached two to five times baseline 0 to 5 days after transplant but the inverse relationship between sEPO and haematocrit was maintained. Observed to expected log sEPO (Epo ratio) rose and fell in parallel with sEPO, remaining greater than 1.0 throughout. A progressive fall in reticulocyte count during chemotherapy was followed by an increase during engraftment. The strong inverse relationships between reticulocytes and Epo ratio in the 10 days after initiating chemotherapy support the hypothesis that loss of EPO-receptor bearing erythroid precursors allows a rise in sEPO during chemotherapy. The elevation of Epo ratio levels during engraftment indicates that it is the availability of EPO-sensitive progenitors, rather than the supply of EPO, that limits the rate of resumption of erythropoiesis after high-dose chemotherapy. [less ▲]

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See detailA Frequency-Domain Processor for ScanSAR Images
Barbier, Christian ULg; Rosello-Guasch, Josep

in Preparing for the Future (1995), 5(4), 6-7

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See detailBiologie de la reproduction de deux espèces de Chrysichthys (Siliuriforme, Bagridae) du Lac Nokoué et de la lagune de Porto-Novo au Bénin.
Laleye, P.; Philippart, Jean-Claude ULg; Poncin, Pascal ULg

in Journal of African Zoology = Revue de Zoologie Africaine (1995), 109(3), 213-224

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See detailUn cimetière, une communauté, un espace : l’exemple liégeois
Schmitz, Serge ULg

in Géographie et cultures (1995), 16

The article is the result of the study of 160 years of cemetery history in an urban region which houses today 510.000 peoples. It demonstrates the strong links between urban and rural communities and ... [more ▼]

The article is the result of the study of 160 years of cemetery history in an urban region which houses today 510.000 peoples. It demonstrates the strong links between urban and rural communities and their cemeteries. In order to do this, four points in cemetery history, chosen for the availability of reliable and comparable sources, have been chosen and described successively. Finally the article investigates the reasons for the exponential growth of requiered cemetery size. [less ▲]

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See detailSpatio-temporal aquatic vegetation patterns in former channels in relation to their isolation from the river Rhine (Eastern France)
Klein, J. P.; Robach, F.; Vanderpoorten, Alain ULg et al

in Acta Botanica Gallica : Bulletin de la Société Botanique de France (1995), 142

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See detailThe effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine.
Tfelt-Hansen, P.; Henry, P.; Mulder, L. J. et al

in Lancet (1995), 346(8980), 923-6

Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg ... [more ▼]

Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS+MTC) with oral sumatriptan (100 mg) and placebo in 421 patients with migraine. LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57% and 53%, respectively, for the first migraine attack treated. Both treatments were better than placebo (success rate 24%, p < 0.0001). LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p < 0.0001) and was better tolerated (adverse events in 18% and 28%, respectively, p < 0.05). LAS+MTC is as effective as sumatriptan in the treatment of migraine attacks. It is also much cheaper. [less ▲]

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See detailThe Dissociative Ionization of Carbon Dioxide below 21.22 eV. A high Resolution PIPECO spectroscopic investigation.
Locht, Robert ULg

in International Journal of Mass Spectrometry and Ion Processes (1995), 148

The photoion-photoelectron spectrum of O+, CO+ and CO2+ has been investigated under high resolution conditions. The O+ ion production is found not to be restricted to the CO2+ (C2Sigma+/g,0,0,0 ... [more ▼]

The photoion-photoelectron spectrum of O+, CO+ and CO2+ has been investigated under high resolution conditions. The O+ ion production is found not to be restricted to the CO2+ (C2Sigma+/g,0,0,0) predissociation. The (0,1,0) and (1,0,0) levels are clearly shown to be involved. The CO+ ion production involves all the vibrational states reached in the Franck-Condon region, i.e. up to (2,0,1) at 19.94 eV. The CO2+ molecular ion does not survive the predissociation in the entire range covered in the present work. [less ▲]

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See detailNumber and relative size of thenar motor units estimated by an adapted multiple point stimulation method.
Wang, François-Charles ULg; Delwaide, Paul ULg

in Muscle & nerve (1995), 18(9), 969-79

An adapted multiple point stimulation (AMPS) method is described for estimating the number and relative size of thenar motor units. With this method, the median nerve was stimulated at various sites from ... [more ▼]

An adapted multiple point stimulation (AMPS) method is described for estimating the number and relative size of thenar motor units. With this method, the median nerve was stimulated at various sites from the wrist to the elbow. To avoid alternation, only two or three clearly identifiable surface-recorded motor unit action potentials (S-MUAPs) were recruited at each point by incremental stimulation. A total of 10 S-MUAPs, elicited from four to five distinct stimulation points, was used to calculate the average S-MUAP size. By dividing the maximum M-potential size by that value, a motor unit number estimate (MUNE) was derived. In 59 healthy volunteers, from 19 to 87 years old, the mean average S-MUAP size was 87 +/- 27.6 microV.ms and the mean MUNE was 278 +/- 113 motor units. When performed repeatedly, the results were reproducible. The number of motor units declined exponentially with age while average S-MUAP sizes increased only moderately. To assess the validity of the AMPS method, its results were correlated with those obtained using the F-response technique. The correlation coefficient was 0.83 (P < 0.001). [less ▲]

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See detailMéthodologie pour une meilleure représentation spatio-temporelle des fluctuations pluviométriques observées au Niger depuis 1905
Ozer, Pierre ULg; Erpicum, Michel ULg

in Sécheresse (1995), 6(1), 103-108

The fluctuations of annual precipitation observed in Niamey and Zinder (Niger) since the turn of the century warranted a comparison of rainfall maps and rainy-season characteristics between 1950-1967 ... [more ▼]

The fluctuations of annual precipitation observed in Niamey and Zinder (Niger) since the turn of the century warranted a comparison of rainfall maps and rainy-season characteristics between 1950-1967 (period of high rainfall) and 1968-1985 (period of low rainfall). Calculating two specific annual spatiotemporal rainfall profiles provided precisions as to the irregular and heterogeneous advance of the drought through Niger. [less ▲]

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See detailNetherton’s syndrome in two sisters. A ten year experience of therapy with retinoids
Groves, S.; Dezfoulian, Bita ULg; Bonardeaux, Ch et al

in Journal of the European Academy of Dermatology & Venereology (1995)

Netherton’s syndrome is a recessive autosomal disease associating ichthyosiform dermatosis, hair dysplasia and systemic involvement. (Netherton, 1958, Arch. Dermatol., Vol. 78,483-487). We report the ... [more ▼]

Netherton’s syndrome is a recessive autosomal disease associating ichthyosiform dermatosis, hair dysplasia and systemic involvement. (Netherton, 1958, Arch. Dermatol., Vol. 78,483-487). We report the observation of two sisters who present the complete form of Netherton’s syndrome. Both patients were treated with retinoids for more than ten years. [less ▲]

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See detailCytokines and cartilage degradation
Henrotin, Yves ULg; De Groote, D; Labasse, A et al

in Mediators of Inflammation (1995), 4

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See detailPersonal name anomia: A single case study
Fery, P.; Vincent, Eric ULg; Brédart, Serge ULg

in Cortex (1995), 31

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See detailDélimitation des hinterlands des agglomérations urbaines au départ d’une image de télédétection
Donnay, Jean-Paul ULg

in Revue Belge de Géographie (1995), 3-4(59), 325-331

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See detailLa géodésie spatiale à l'Observatoire Royal de Belgique
Warnant, René ULg; Bruyninx, Carine

in Nouvelles de la Science et des Technologies (1995), 13(2/3/4), 29-31

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See detailBreakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates.
Damblon, Christian ULg; Zhao, G. H.; Jamin, M. et al

in Biochemical Journal (1995), 309 ( Pt 2)

With peptide analogues of their natural substrates (the glycopeptide units of nascent peptidoglycan), the DD-peptidases exhibit a strict preference for D-Ala-D-Xaa C-termini. Gly is tolerated as the C ... [more ▼]

With peptide analogues of their natural substrates (the glycopeptide units of nascent peptidoglycan), the DD-peptidases exhibit a strict preference for D-Ala-D-Xaa C-termini. Gly is tolerated as the C-terminal residue, but with a significantly decreased activity. These enzymes were also known to hydrolyse various ester and thiolester analogues of their natural substrates. Some thiolesters with a C-terminal leaving group that exhibited L stereochemistry were significantly hydrolysed by some of the enzymes, particularly the Actinomadura R39 DD-peptidase, but the strict specificity for a D residue in the penultimate position was fully retained. These esters and thiolesters also behave as substrates for beta-lactamases. In this case, thiolesters exhibiting L stereochemistry in the ultimate position could also be hydrolysed, mainly by the class-C and class-D enzymes. However, more surprisingly, the class-C Enterobacter cloacae P99 beta-lactamase also hydrolysed thiolesters containing an L residue in the penultimate position, sometimes with a higher efficiency than the D isomer. [less ▲]

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See detailcorrelations between cerebral blood flow velocities, cerebral perfusion pressure and intracranial pressure in sick neonates
Battisti, Oreste ULg; Adant-François, A.; Bertrand, J. M. et al

in Circulation et Métabolisme du Cerveau (1995), 12

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See detailMorphological Changes of Thymus in Retrovirus-Induced Murine Acquired Immunodeficiency Syndrome (Maids)
de Leval, Laurence ULg; Deprez, Manuel ULg; Colombi, S. et al

in Pathology - Research & Practice (1995), 191(6), 506-12

The possible contribution of the thymus in the setting of acquired immunodeficiencies is still questioned. Here we report some new findings regarding a potential involvement of the thymus in mice infected ... [more ▼]

The possible contribution of the thymus in the setting of acquired immunodeficiencies is still questioned. Here we report some new findings regarding a potential involvement of the thymus in mice infected with RadLV-Rs, a viral mixture inducing murine acquired immunodeficiency syndrome (MAIDS). Thymi were sequentially removed, weighted and morphologically analyzed at different time intervals post-infection. Infection with RadLV-Rs led to a decrease in thymus weight mostly apparent from the fourth week. The first changes were seen at the third week as perivascular clusters of B-cells at the cortico-medullary junction. The ensuing process of atrophy mainly involved the cortex, while a mixed population of large T- and B-cells filled the medulla. These observations are discussed with regard to the pathological changes occurring in other lymphoid and non-lymphoid organs, in the context of the lymphoproliferation and immunodeficiency characterizing the disease, and by comparison with other models of retrovirus-induced immunodeficiencies. [less ▲]

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See detailNonfibrous mineralogical analysis of bronchoalveolar lavage fluid from blast-furnace workers.
CORHAY, Jean-Louis ULg; Bury, Thierry ULg; Delavignette, Jean-Paul ULg et al

in Archives of Environmental Health (1995), 50(4), 312-9

Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We demonstrated previously that steelworkers may be subject to an occult exposure to amphiboles in the plant ... [more ▼]

Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We demonstrated previously that steelworkers may be subject to an occult exposure to amphiboles in the plant environment. In the current study, we further analyzed bronchoalveolar lavage fluid of steelworkers by measuring intramacrophagic trace-metal content and nonfibrous mineral particles, using the particle-induced x-ray emission method and electron microscopy, respectively. Forty-seven blast-furnace workers and 45 healthy white-collar workers volunteered for this study. Significantly increased levels of iron, titanium, zinc, and bromine were found in the steelworkers, and levels of lead, chromium, arsenic, and strontium tended to increase in the macrophages and bronchoalveolar lavage fluid of the steelworkers. Nonfibrous particles, including illite, kaolinite, talc, chlorite, amorphous silica, quartz, iron (compounds), and titanium hydroxide, were found in both groups, but the particle number per ml bronchoalveolar lavage fluid (particularly iron hydroxides and silicates) was more pronounced in blast-furnace workers. These elements and particles may act synergistically with other occupational carcinogens and cigarette smoke, the result of which may be an increased incidence of lung cancer in the ironsteel industry. [less ▲]

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See detailISOLATION OF SUCROSE SYNTHASE FROM RICE (ORYZA-SATIVA) GRAINS IN PILOT-SCALE FOR APPLICATION IN CARBOHYDRATE SYNTHESIS
ELLING, Lothar; GULDENBERG, Birgit; GROTHUS, Marita et al

in Biotechnology & Applied Biochemistry (1995), 21(Part 1), 29-37

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the ... [more ▼]

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the 9 kg scale of rice (Oryza sativa) grains was achieved in five steps with 11.3% yield and 192-fold purification. The final sucrose synthase preparation was free of nucleotide di- and monophosphatases, but did contain 0.05% of both invertase and UDP-glucose-hydrolysing activity. It can be efficiently utilized for the synthesis of activated sugars. Its application for the synthesis of saccharides is possible taking into account that 15% UDP-glucose is hydrolysed within 15 h incubation time [less ▲]

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See detailChimiosensibilité in vivo et in vitro de Plasmodium falciparum à Brazzaville (Congo)
Chandenier, Jacques; Ndounga, Mathieu; Carme, Bernard et al

in Santé : Cahiers d'Etude et de Recherches Francophones (1995), 5(1), 25-29

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to ... [more ▼]

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to halofantrine was investigated in an in vitro survey using an isotopic micro test. The resistance rates were 61.8, 14.7, 3.0 and 0.0% respectively. Thus, the chemoresistance which first appeared in 1990 is confirmed and is stable in the population. This finding was further confirmed by a parallel in vitro analysis of sensitivity to chloroquine in Brazzaville. A chloroquine monitoring network is now being established throughout the country based on simplified WHO tests of 100 asymptomatic schoolchildren conducted every six months. The first results in 1993, from three Southern regions indicate that parasites are found in 20 to 60% of cases seven days after a standard 3 day treatment with 25 mg/kg, according to the region. The results of in vitro and in vivo tests are very variable. Indeed, the value of such results for these tests for national monitoring is questionable: a more reliable system of identifying true therapeutic failures would be better suited. [less ▲]

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See detailSituation actuelle de la loutre, Lutra lutra, en Belgique et problématique de sa conservation
Libois, Roland ULg; Hallet, Catherine

in Cahiers d'Ethologie (1995), 15(2-3-4), 157-168

Widespread all over the country till the end of the last century, the otter has rapidly declined. In 1973 when hunting was definitely closed, the otter was already threatened and restricted to a few ... [more ▼]

Widespread all over the country till the end of the last century, the otter has rapidly declined. In 1973 when hunting was definitely closed, the otter was already threatened and restricted to a few localities. In 1889, the Belgian Ministry of agriculture decided to pay bounties for otters, a system which was cancelled only in 1963. Game statistics of the past century allow the annual otter bag to evaluated as roughly 25 % of the standing population. As it is the case in other European industrialised countries, freshwater habitat loss and water pollution lead to a considerable decrease of the river carrying capacity. Almost all the rivers flowing in the Northern part of Belgium are now lifeless or at least in a very bad condition. South of the river Meuse, some accidental pollutions are regularly reported (chloring in the river Ourthe in 1993; chloracetic acid in the Sûre in 1990...) and the level of organic pollution rises from year to year. Moreover, the tourism (angling, camp sites, kayak) nare more and more intensive leading to major disturbances, particularly during the summer months. Finally, the Ministery of equipment is developing a policy of big hydraulic works (dams, embankments, dredging...) along the river Ourthe, one of the last to be occupied by a few otters. [less ▲]

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See detailThe dexamethasone suppression test in violent suicide attempters with major depression.
Pitchot, William ULg; Hansenne, Michel ULg; Gonzalez Moreno, A. et al

in Biological Psychiatry (1995), 37(4), 273-4

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See detailLes insuffisances mitrales ischémiques: principes de leur traitement chirurgical
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 295-7

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou ... [more ▼]

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou chroniques de la maladie ischémique. Leur compréhension est facilité par la classification fonctionnelle de Carpentier. A l'occasion de cette revue, nous précisons les indications elles modalités de traitement de ce type d'insuffisance mitrale. [less ▲]

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See detailPrésence d'appendices mucoïdes sur les ascospores de Raciborskiella janeirensis (Müll. Arg.) R. Sant.
Roux, Claude; Sérusiaux, Emmanuël ULg

in Bulletin de la Société Linnéenne de Provence (1995), 46

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See detailA Simple Model for the Fire Resistance of Axially-Loaded Members According to Eurocode 3
Franssen, Jean-Marc ULg; Schleich, Jean-Baptiste; Cajot, Louis-Guy

in Journal of Constructional Steel Research (1995), 35

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental ... [more ▼]

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental test results. This model has been subsequently included in Eurocode 3. [less ▲]

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See detailManagement of high turnover osteoporosis with calcitonin
Reginster, Jean-Yves ULg

in Osteoporosis Digest (1995), 3

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See detailLe développement des fonctions du langage en vue d’une meilleure intégration linguistique: le cas des Italiens de Belgique
Lucchini, Silvia ULg

in Cahiers de l'institut de linguistique de Louvain (1995), 21(1-2), 149-156

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See detailTroubles du rythme et risques somatiques chez le petit enfant
Gauthier, Jean-Marie ULg

in Thérapie Psychomotrice et Recherches (1995), 102

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See detailLes participes présents féminins actifs dans l'Avesta
Swennen, Philippe ULg

in Annali (1995)

In Avestan, much feminine present participles in the active voice are problematic. However, the behaviour of the epenthesis of the feminine suffix is quite perfectly regular.

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See detailHow should zoster trials be conducted?
Wood, M. J.; Balfour, Hank; Beutner, Karl et al

in Journal of Antimicrobial Chemotherapy (1995), 36(6), 1089-1101

In 1994, an international group of interested clinicians and biostatisticians met to discuss the design of clinical trials in herpes tester. They agreed that trials in herpes tester should have ... [more ▼]

In 1994, an international group of interested clinicians and biostatisticians met to discuss the design of clinical trials in herpes tester. They agreed that trials in herpes tester should have prospectively agreed definitions of all outcome measures and plans for data analysis. In immunocompetent individuals, in whom pain is the major outcome measure, trials should only include patients over the age of 50 years, and for those recruited within 72 fi of rash onset, should be designed to demonstrate superiority of any new therapy over existing antivirals. The primary endpoint should be time to cessation of pain for at least 4 weeks and, for the purposes of statistical analysis of its duration, the pain associated with herpes tester ought to be considered as a continuum. All other variables, including the incidence of post-herpetic neuralgia and effects upon quality of life should be considered as secondary end-points. Evaluation of treatment effects on primary endpoints should be based upon an intent-to-treat (ITT) analysis and subgroup analysis should be used only to support the findings of the ITT analysis. These elements of good study design should be borne in mind in the evaluation of current and future trails of antiviral drugs in herpes zoster. [less ▲]

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See detailLack of LTR and ENV genetic variation during bovine leukemia virus-induced leukemogenesis.
Willems, Luc ULg; Kerkhofs, P.; Burny, A. et al

in Virology (1995), 206(1),

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See detailPriming production of people's names
Valentine, T.; Moore, V.; Brédart, Serge ULg

in Quarterly Journal of Experimental Psychology (1995), 48A

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See detailUtilisation de la paille dans des rations d'engraissement: ingestion, dynamique de la digestion et cinétique de dégradabilité dans le rumen
Mayombo, Asangule Pierre; Van Eenaeme, Christian ULg; Gauthier, Sabine et al

in Annales de Zootechnie (1995), 44

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See detailStochastic generation of precipitation and effect on vegetation net primary production
Hubert, Benoît ULg; François, Louis ULg; Warnant, Pierre ULg

in Global Energy and Water Cycle Experiment news (1995), 5

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See detailMiospore Biozonation in the Middle Devonian - Lower Carboniferous of Europe : its application to Western Gondwana
Loboziak, S.; Streel, Maurice ULg

in Anais da Academia Brasileira de Ciencias (1995), 67(3), 311-312

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See detailLong run behaviour of Pacific-Basin stock prices
Corhay, Albert ULg; Tourani-Rad, Alireza; Urbain, Jean-Pierre ULg

in Applied Financial Economics (1995), 5(1), 11-18

In this paper, we investigate the long run relationship among five major Pacific-Basin stock markets. We focus on the common long run behaviour of their stock price indices over a sample period of 20 ... [more ▼]

In this paper, we investigate the long run relationship among five major Pacific-Basin stock markets. We focus on the common long run behaviour of their stock price indices over a sample period of 20 years. Using cointegration theory, we find that while there exists a rather integrated Pacific Basin financial area, the regional aspects (Asian versus Pacific) play important roles. [less ▲]

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See detailSecondary structure of monoamine oxidase by FTIR spectroscopy.
Wouters, J.; Ramsay, R.; Goormaghtigh, E. et al

in Biochemical and Biophysical Research Communications (1995), 208(2), 773-8

The secondary structure of human monoamine oxidase A and bovine monoamine oxidase B has been investigated by Fourier Transform Attenuated Total Reflection Spectroscopy (FTIR ATR). The experimental results ... [more ▼]

The secondary structure of human monoamine oxidase A and bovine monoamine oxidase B has been investigated by Fourier Transform Attenuated Total Reflection Spectroscopy (FTIR ATR). The experimental results are compared for both isoenzymes and the data are incorporated in a statistical attribution of secondary structure of the enzyme describing the distinct folding and molecular specificity of the two types of monoamine oxidase. [less ▲]

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See detailHandling infinite temporal data
Kabanza, Froduald; Stevenne, Jean-Marc; Wolper, Pierre ULg

in Journal of Computer & System Sciences (1995), 51(1), 3--17

In this paper, we present a powerful framework for describing, storing, and reasoning about infinite temporal information. This framework is an extension of classical relational databases. It represents ... [more ▼]

In this paper, we present a powerful framework for describing, storing, and reasoning about infinite temporal information. This framework is an extension of classical relational databases. It represents infinite temporal information by generalized tuples defined by linear repeating points and constraints on these points. We characterize the expressiveness of these generalized relations in terms of predicates definable in Presburger arithmetic. Next, we prove that relations formed from generalized tuples are closed under the operations of relational algebra and provide complexity results for the evaluation of first-order queries. [less ▲]

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See detailToxicité potentielle et utilisation pratique du méthotrexate dans la polyarthrite rhumatoïde
Kaye, O.; Ribbens, Clio ULg; Hauwaert, Christian ULg et al

in Médecine et Hygiène (1995)

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See detailBiological-Activity Of Fenoxycarb Against Sitophilus-Zeamais Motsch (Coleoptera, Curculionidae)
Letellier, C.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Journal of Stored Products Research (1995), 31(1),

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See detailLa recherche scientifique et l'invention d'une société solidaire
de Landsheere, Gilbert ULg

in Bulletin de l'Association de la Noblesse du Royaume de Belgique (1995), (206), 22-28

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See detailThe rationale to switch from postoperative hyperfractionated accelerated radiotherapy to preoperative hyperfractionated accelerated radiotherapy in rectal cancer
COUCKE, Philippe ULg; Sartirelli, Britta; Cuttat, Jean-François et al

in International Journal of Radiation, Oncology, Biology, Physics (1995), 32(1), 181-188

Purpose: To demonstrate the feasibility of preoperative Hyperfractionated Accelerated RadioTherapy (preop-HART) in rectal cancer and to explain the rationales to switch from postoperative HART to ... [more ▼]

Purpose: To demonstrate the feasibility of preoperative Hyperfractionated Accelerated RadioTherapy (preop-HART) in rectal cancer and to explain the rationales to switch from postoperative HART to preoperative HART. Methods and Materials: Fifty-two consecutive patients were introduced in successive Phase I trials since 1989. In trial 89-01, postoperative HART (48 Gy in 3 weeks) was applied in 20 patients. In nine patients with locally advanced rectal cancer, considered unresectable by the surgeon, 32 Gy in 2 weeks was applied prior to surgery (trial 89-02). Since 1991, 41.6 Gy in 2.5 weeks has been applied preoperatively to 23 patients with T3-T4 any N rectal cancer immediately followed by surgery (trial 91-01). All patients were irradiated at the department of radiation-oncology with a four-field box technique (1.6 Gy twice a day and with at least a 6-h interval between fractions). The minimal accelerating potential was 6 MV. Acute toxicity was scored according to the World Health Organization (WHO for skin and small bowel) and the Radiation Therapy Oncology Group criteria (RTOG for bladder). This was done weekly during treatment and every 3 months thereafter. Small bowel volume was estimated by a modified 'Gallagher's' method. Results: Acute toxicity was acceptable both in postoperative and preoperative setup. The mean acute toxicity was significantly lower in trial 91-01 compared to 89-01. This difference was due to the smaller amount of small bowel in irradiation field and lower total dose in trial 91-01. Moreover, there was a significantly reduced delay between surgery and radiotherapy favoring trial 91-01 (median delay 4 days compared to 46 days in trial 89-01). Nearly all patients in trial 89-02 and 91-01 underwent surgery (31 out of 32; 97%). Resection margins were negative in 29 out of 32. Hospitalization duration in trial 91- 01 was not significantly different from trial 89-01 (19 vs. 21 days, respectively). Conclusions: Hyperfractionated accelerated radiotherapy immediately followed by surgery is feasible as far as acute toxicity is concerned. Preoperative HART is favored by a significantly lower acute toxicity related, in part, to a smaller amount of irradiated small bowel, and a shorter duration of the delay between radiotherapy and surgery. Moreover, the hospital stay after preoperative HART is not significantly increased. [less ▲]

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