References of "Article"
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See detailMBO en Aandeelhouder
Corhay, Albert ULg; Herst, Arthur; Tourani Rad, Alireza

in Bedrifskunde (1994), 4

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See detailParadoxe sur le philosophe (kant entre Bourdieu et Derrida)
Steinmetz, Rudy ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994)

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See detailLes méthodes d'analyse factorielle : principes et applications
Palm, Rodolphe ULg

in Biométrie-Praximétrie (1994), 34

This note describes in a simple way the principles of the factorial methods, and more particularly of the principal component anlaysis and the correspondence analysis. The emphasis is put on the elements ... [more ▼]

This note describes in a simple way the principles of the factorial methods, and more particularly of the principal component anlaysis and the correspondence analysis. The emphasis is put on the elements useful when interpreting the results of an analysis and the methods are illustrated by completely worked out examples. [less ▲]

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See detailLe paradis d'une ville au siècle de Louis XIV
George, Philippe ULg

in Annales du Cercle Hutois des Sciences et Beaux-Arts (1994), XLVIII

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See detailL'agrégé nouveau est arrivé !
Jadoulle, Jean-Louis ULg

in Bulletin de Clio (1994)

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See detailModular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM
Kishan, Radha; Zeelen, Ph. Johan; Noble, Martin E.M. et al

in Protein Engineering (1994), 7(8), 945-51

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha ... [more ▼]

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha-unit of E. coli TIM with the equivalent unit of chicken TIM. This replacement involves 10 sequence changes. One of the changes concerns the mutation of a buried alanine (Ala232 in strand 8) into a phenylalanine. The ETIM8CHI structure shows that the A232F sequence change can be incorporated by a side-chain rotation of Phe224 (in helix 7). No cavities or strained dihedrals are observed in ETIM8CHI in the region near position 232, which is in agreement with the observation that ETIM8CHI and E.coli TIM have similar stabilities. The largest CA (C-alpha atom) movements, approximately 3 A, are seen for the C-terminal end of helix 8 (associated with the outward rotation of Phe224) and for the residues in the loop after helix 1 (associated with sequence changes in helix 8). From the structure it is not clear why the kcat of ETIM8CHI is 10 times lower than in wild type E.coli TIM. [less ▲]

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See detailLa régression linéaire pondérée : principes et application
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1994), 4

This note briefly describes the prinicples of weighted linear regression and gives two completely worked out examples from the real world.

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See detailUtilisation du milieu et étude du dommaine vital chez le martin pêcheur en période de reproduction
Loncin, Anne; Libois, Roland ULg

in Aves (1994), 31(2-3-4), 197-198

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See detailAge-related differences in updating working memory
Van der Linden, Martial ULg; Brédart, Serge ULg; Beerten, A.

in British Journal of Psychology (1994), 85(1), 145-152

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See detailTwo silencing sub-domains of v-erbA synergize with each other, but not with RXR.
Martin, Bernd; Renkawitz, Rainer; Muller, Marc ULg

in Nucleic Acids Research (1994), 22(23), 4898-905

The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) induce gene expression in the presence of specific ligand and repress transcription in the absence of hormone. This repression is ... [more ▼]

The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) induce gene expression in the presence of specific ligand and repress transcription in the absence of hormone. This repression is mediated by an active silencing mechanism rather then by interference with DNA binding activators. V-erbA, a variant form of TR which is unable to bind hormone, represents a constitutive repressor. Here we show, using fusion proteins with the GAL4 DNA binding domain, that the minimal silencing domain of v-erbA extends from amino acids 389 to 632 and that internal deletions within this domain retain at least some repression function. Co-transfection experiments of different deletion mutants indicate that the silencing domain is composed of at least two sub-domains which are non-functional when tested individually. When combined in a heterodimeric complex, they synergize such that silencing activity is regained. In contrast to the retinoic acid receptor the retinoid X receptor does not contain a silencing domain. In addition it is unable to cooperate with the repression function of TR or v-erbA in a heterodimer. [less ▲]

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See detailVimentinoma, an Unusual Neoplasm of the Skin
Hermanns-Lê, Trinh ULg; Nikkels, Arjen ULg; Ammar et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1994), 189(1), 84-86

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and ... [more ▼]

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and electron microscopy. 'Vimentinoma' appears to be the most appropriate name for this neoplasm. [less ▲]

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See detailEfficacité de la radiothérapie pour le traitement des récidives en gynécologie oncologique
COUCKE, Philippe ULg; Sartorelli, B

in Revue Médicale de la Suisse Romande (1994), 114(9), 799-804

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See detailLes spermatozoïdes ont-ils du nez ?
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Parmentier, M. et al

in Medecine Sciences : M/S (1994), 10

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See detailTopographic forcing of the circulation of LIW in the Western Mediterranean
Alvarez, A.; Tintoré, J.; Holloway, G. et al

in Coastal Estuarine Studies (1994), 46

Circulation of the Western Mediterranean has been inferred from tracer properties and is the object of numerical modelling studies (eg., Beckers, 1991). The path of the Levantine Intermediate Water (LIW ... [more ▼]

Circulation of the Western Mediterranean has been inferred from tracer properties and is the object of numerical modelling studies (eg., Beckers, 1991). The path of the Levantine Intermediate Water (LIW), thought o be a buoyancy forced flow, provides an indicator of mid-depth circulation (Millot, 1987b). However, modelling studies which include buoyancy forcing appear to misrepresent the flow of LIW. We have used the 'GFDL Modular Ocean Model' (MOM) to explore the suggestion of Holloway (1992) that subgridscale eddy-topography interaction may be responsible for such systematic defects. We have executed MOM with and without the parametrization of the eddytopography interaction. The different results are compared with circulation inferred from observational data. [less ▲]

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See detailPhylogenetic relationships among filamentous helical cyanobacteria investigated on the basis of 16S ribosomal RNA gene sequence analysis
Nelissen, Bart; Wilmotte, Annick ULg; Neefs, Jean-Marc et al

in Systematic & Applied Microbiology (1994), 17

The cyanobacterial genera Spirulina and Arthrospira are both characterized by helical trichomes but their taxonomy is controversial and a phylogenetic study is necessary. The sequence of the 16S rRNA gene ... [more ▼]

The cyanobacterial genera Spirulina and Arthrospira are both characterized by helical trichomes but their taxonomy is controversial and a phylogenetic study is necessary. The sequence of the 16S rRNA gene and the spacer between the 16S and 23S rRNA genes (ITS) was determined for three filamentous coiled cyanobacteria: Spirulina PCC 6313, Arthrospira PCC 7345 and Arthrospira PCC 8005. A distance tree based on the 16S rRNA sequences was constructed using the neighbor-joining method. This tree shows that the two Arthrospira strains are not closely related to the Spirulina strain but belong to a cluster of strains assigned to the genera Oscillatoria, Lyngbya, and Microcoleus. The strain Spirulina PCC 6313 belongs to a branching containing unicellular cyanobacteria. For the two Arthrospira strains, the sequenced ITS region contains the tRNA(Ile) and tRNA(Ala) genes, whereas the spacer region of strain Spirulina PCC 6313 contains only the tRNA(Ile) gene. [less ▲]

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See detailLe Marquis et les castrats. Note sur un tabou sadien
Durand, Pascal ULg

in Art&Fact (1994), 13

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See detailFavoriser la reproduction des poissons à Lanaye.
Poncin, Pascal ULg; Keulen, C.

in Pêcheur Belge (Le) (1994), 6

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See detailLa responsabilité délictuelle des communes
Lewalle, Paul ULg; Dressen, Cécile; Durviaux, Ann-Lawrence ULg

in Revue de Droit Communal (1994)

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See detailReaction Dynamics of Collisionally activated Ammonia Cations.
Leyh, Bernard ULg; Hoxha, A.

in Chemical Physics (1994), 179

In the framework of a research on the collisional mechanisms involved in tandem mass spectrometry, the collisional activation processes of NH3+ with different target gases have been investigated. The ... [more ▼]

In the framework of a research on the collisional mechanisms involved in tandem mass spectrometry, the collisional activation processes of NH3+ with different target gases have been investigated. The experiments have been performed on an upgraded AEI-MS9 sector instrument equipped with two collision cells and include daughter ion spectra, ion kinetic energy spectra, determination of kinetic energy release distributions (KERD) and appearance energy measurements. We have shown that collisionally activated dissociation (CAD) of NH3+ into NH++[H,H] depends upon the internal energy of NH3+. This internal energy effect is also observed for the NH2++H channel, when Xe is the target gas; with He, such an effect could not be detected. The analysis of the KERD shows that production of NH2+ upon CAD takes place from the NH3+ ground electronic state by rotational predissociation; two components are observed, one which corresponds to a near-threshold process (mean kinetic energy release <T>=0.13 eV), and one characterized by <T>=0.56 ev corresponding to an excess energy of 2.1 eV above the dissociation threshold. NH+ fragments can be formed by two processes: the first one occurs at threshold and leads to NH+(X2Pi)+H2(X1Sigma+g); the second one is characterized by large KER values (up to 7 eV) and leads to either electronically excited NH+ or dissociation of H2. [less ▲]

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See detailPhenotypic heterogeneity of the fibroblast-like cells in the dermis
Pierard-Franchimont, Claudine ULg; Fazaa, B.; Benzarti, H. et al

in Giornale Internazionale di Dermatologia Pediatrica (1994), 6(1), 7-13

The fibroblast-like cell population of the dermis is heterogeneous. The name "fibroblast" appears to be out-dated and should be replaced by terms reflecting with precision the immunophenotype of the cells ... [more ▼]

The fibroblast-like cell population of the dermis is heterogeneous. The name "fibroblast" appears to be out-dated and should be replaced by terms reflecting with precision the immunophenotype of the cells. Among them, dendrocytes type I (Factor XIIIa - positive) and dendrocytes type II (CD34 - positive) are involved in a wealth of pathologic conditions. [less ▲]

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See detailDu « bon usage » de la notion de syncrétisme
Pirenne-Delforge, Vinciane ULg; Motte, André ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1994), 7

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See detailCommon Prevalence Of Alanine And Glycine In Mobile Reactive Center Loops Of Serpins And Viral Fusion Peptides - Do Prions Possess A Fusion Peptide
Callebaut, I.; Tasso, A.; Brasseur, Robert ULg et al

in Journal of Computer-Aided Molecular Design (1994), 8(2),

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by ... [more ▼]

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by high levels of glycine. These two small residues, which are not simultaneously abundant in stable helices (standard or transmembrane), probably play an important role in mobility. Threonine and valine (also relatively small amino acids) are also abundant in these two kinds of peptides. Moreover, the known 3D structures of an uncleaved serpin reactive centre and a fusion peptide are strikingly similar. Such sequences possess many small residues and are found in several signal peptides and in PrP, a protein associated with spongiform encephalopathies and resembling virus envelope proteins. These properties may be related to the infection mechanisms of these diseases. [less ▲]

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See detailMetalloproteinases and serine proteases activities in mixed spheroids of mouse B16 melanoma cells and fibroblasts
Coucke, Paul; Baramova, Eugenia; Leprince, Pierre ULg et al

in International Journal of Oncology (1994), 5

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See detailDistribution of POC, PON and particulate Al, Cd, Cr, Cu, Pb, Ti, Zn and deltaC13 in the English Channel and adjacent areas
Dauby, Patrick ULg; Frankignoulle, Michel; Gobert, Sylvie ULg et al

in Oceanologica Acta (1994), 17(6), 643-657

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See detailGelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy.
Polette, M.; Gilbert, N.; Stas, I. et al

in Virchows Archiv : An International Journal of Pathology (1994), 424

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is ... [more ▼]

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is some controversy about its origin. Gelatinase A was localized by immunohistochemistry using confocal microscopy in 15 human mammary carcinomas. In addition, the cells responsible for the synthesis of this enzyme were detected by in situ hybridization. Most invasive and non-invasive tumour cells were labelled by immunohistochemistry. Of particular interest was the pattern observed in some pre-invasive areas. Gelatinase A was found in fibroblasts in close contact with pre-invasive tumour clusters. Confocal observation allowed a more precise localization of gelatinase A to the periphery of tumour clusters along the basement membranes and in peritumour fibroblasts. The malignant epithelial cells were negative by immunohistochemistry in these areas. By in situ hybridization, mRNAs encoding gelatinase A were detected only in fibroblasts in close contact with pre-invasive and well differentiated tumour clusters. These findings support the hypothesis that peritumour fibroblasts produce gelatinase A and that breast cancer cells may bind this enzyme to their cell surface and/or internalize it. [less ▲]

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See detailA new species of trametes from Papua New Guinea
Castillo Cabello, Gabriel ULg

in Mycotaxon (1994)

Trametes demoulinii from Papua New guinea is descrebed as new. The new taxon is closest to Trametes conchifer and Trametes membranacea, both from America and Trametes cingulata know in Africa and East ... [more ▼]

Trametes demoulinii from Papua New guinea is descrebed as new. The new taxon is closest to Trametes conchifer and Trametes membranacea, both from America and Trametes cingulata know in Africa and East Asia. In addition to basidiomata, cultural characters of the new species are described. [less ▲]

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See detailL'inventaire forestier régional wallon: brève présentation méthodologique.
Lecomte, H.; Rondeux, Jacques ULg

in Silva Belgica (1994), 101(6), 9-16

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie ... [more ▼]

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie [RONDEUX et al., 1984]. Cet inventaire s’appuyant sur un échantillonnage systématique simple était destiné à fournir un état des lieux de la forêt wallonne de l’époque ; il a notamment permis de confirmer ou de mettre en évidence plusieurs éléments essentiels pour l’avenir du patrimoine forestier wallon [RONDEUX et al., 1986] : - le vieillissement de la hêtraie ardennaise ; - l’importante disponibilité en bois d’épicéa ; - les écarts entre les surfaces forestières observées et celles du recensement officiel. Depuis la fin de cet inventaire en 1984, aucune mise à jour n’a été programmée et en conséquence, ses résultats ont perdu leur fiabilité notamment en raison des accidents météorologiques de la dernière décennie. En 1988, l’Exécutif de la Région Wallonne, conscient de l’importance de la forêt en tant que première ressource naturelle renouvelable de la Wallonie, a sollicité la Faculté des Sciences agronomiques de Gembloux en vue de finaliser une recherche destinée à concevoir une méthodologie d’inventaire forestier permanent. Les conclusions de cette étude ont été déposées fin 1993 [LECOMTE, 1994], ce qui a permis de lancer dès février 1994 la phase opérationnelle du premier inventaire forestier permanent pour la Wallonie. Dans les lignes qui suivent, nous aborderons successivement les objectifs de l’inventaire (paragraphe 2) ainsi que les principes généraux qui le régissent (paragraphe 3). Le cheminement de l’information sera décrit depuis la récolte des données (paragraphe 4) jusqu’à la publication des résultats (paragraphe 7) en passant par le traitement et l’exploitation des données (paragraphes 5 et 6). En guise de conclusions, nous émettrons quelques réflexions issues de notre propre expérience (paragraphe 8). [less ▲]

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See detailThiamine in Excitable Tissues: Reflections on a Non-Cofactor Role
Bettendorff, Lucien ULg

in Metabolic Brain Disease (1994), 9(3), 183-209

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See detailLe chylothorax et son traitement
Detry, Olivier ULg; Dekoster, Guy ULg; Limet, Anne ULg

in Lyon Chirurgical (1994), 90(1), 38-44

Chylothorax is an unfrequent pathology defined by fistula between the thoracic duct and one of the pleura. Its spontaneous evolution is worse, with respiratory failure in the acute phase. After a few days ... [more ▼]

Chylothorax is an unfrequent pathology defined by fistula between the thoracic duct and one of the pleura. Its spontaneous evolution is worse, with respiratory failure in the acute phase. After a few days of thoracic tube drainage, hemodynamic, nutritional and immunologic disturbances appear. Since the first thoracic duct ligature by Lampson in 1948, surgical approach has obviously reduced the morbidity and mortality of chylothorax. The new development of the thoracoscopic techniques will allow earlier and less aggressive surgical treatment. However, thoracic surgeons must keep in mind that every intrathoracic operation could induce chylothorax, especially in case of posteriror mediastinal surgery. Chylothorax must be evocated if unusually profuse milky pleural effusion complicate this type of procedure. We discribe the anatomy and the physiology of chylous circulation and we discuss the etiologies and the different therapeutic approaches of chylothorax. [less ▲]

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See detailLATTICE-DYNAMICS AND DIELECTRIC-PROPERTIES OF INCIPIENT FERROELECTRIC TIO2 RUTILE
LEE, C.; Ghosez, Philippe ULg; GONZE, X.

in Physical Review. B : Condensed Matter (1994), 50(18), 13379-13387

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See detailThymus Involvement in Murine Acquired Immunodeficiency (Maids)
Colombi, Sonia; Deprez, Manuel ULg; de Leval, Laurence ULg et al

in Thymus (1994), 23(1), 27-37

Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced ... [more ▼]

Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced cytopathic effects on T-cells in the periphery. Therefore, thymus weight, cell numbers, and subset distribution were sequentially analysed after infection with RadLV-Rs, a viral mixture known to induce murine retrovirus induced immunodeficiency (MAIDS). Infection induced thymic atrophy (concerning organ weight as well as total cell number) which culminated seven weeks after inoculation. The atrophic process mostly reflected the depletion of double positive CD4+ CD8+ cells since their proportion sharply decreased around week 6. Single positive T-cells were less affected by the process. The proportion of B-cells progressively increased. Surprisingly, there was a strong correlation between the extent of atrophy and the frequency of B-cells in the thymus. Finally, an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in the periphery also appeared in the thymus and its frequency was strongly correlated with the expansion of B-cells in this organ. [less ▲]

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See detailEFFECTS OF ELECTROKINETIC CHARACTERISTICS ON THE FORMATION OF A PROTEIN MICROCRYSTALLINE CELLULOSE COMPLEX
Paquot, Michel ULg; GODIN, F.; Dumont de chassart, Q.

in Lebensmittel-Wissenschaft & -Technologie = Food Science & Technology (1994), 27(1), 11-15

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See detailObservations de coupes dans la terrasse T3 dans la vallée du Niger en aval de Niamey
Willems, Luc ULg; Bergoing, Jean-Pierre

in Revue de Géographie Alpine (1994), 5

Dans la région de Niamey, l'étendue et le nombre d'affleurements du complexe T3, appelé aussi terrasse moyenne, permettent de dresser une chronologie relative des événements climatiques survenus dans la ... [more ▼]

Dans la région de Niamey, l'étendue et le nombre d'affleurements du complexe T3, appelé aussi terrasse moyenne, permettent de dresser une chronologie relative des événements climatiques survenus dans la région durant son édification. Une étude systématique révèle une grande diversité dans les dépôts souvent assimilable aux variations locales de sédimentation. Cependant, cinq épisodes majeurs dans l'édification du complexe peuvent être dégagés et correspondent à autant de fluctuations climatiques durant une période qui s'étendrait de 20 000 à 12 000 BP. La découverte et l'observation de diaclases ainsi que des phénomènes de soutirage dans les dépôts pléistocènes montrent le rôle important qu'a pu jouer la fracturation du socle birrimien sur l'ensemble de la morphologie actuelle de la région de Niamey, en particulier sur le réseau hydrographique. [less ▲]

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See detailPure red cell aplasia following peripheral stem cell transplantation: complete response to a short course of high-dose recombinant human erythropoietin.
Martelli, M.; Ponchio, L.; Beguin, Yves ULg et al

in Haematologica (1994), 79(5), 456-9

We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia ... [more ▼]

We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia. Corticosteroid treatment was ineffective. Four months after transplantation rHuEpo was administered subcutaneously at a dose of 150 U/Kg per day, five days a week for 8 weeks. Treatment induced an erythropoietic response and corrected anemia. Response was maintained following discontinuation of rHuEpo. This study and previous reports indicate that high doses of rHuEpo given over a short time can resolve PRCA following autologous or allogeneic stem cell transplantation. [less ▲]

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See detailPolylactide Microparticules Prepared by Double Emulsion/Evaporation Technique. I. Effect of Primary Emulsion Stability
Nihant; Schugens, Chantal; Grandfils, Christian ULg et al

in Pharmaceutical Research (1994), 11(10), 1479-1484

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound ... [more ▼]

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound is emulsified into an organic solution of the hydrophobic coating polymer; second, this primary water-in-oil (w/o) is dispersed in water with formation of a double water-oil-water emulsion (w/o/w), third, the organic solvent is removed with formation of solid microparticles. This paper focuses of the effect of primary emulsion stability on the morphology and properties of polylactide microparticles loaded with bovine serum albumin (BSA) used as model drug. [less ▲]

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See detailBehavioural study of hybridization between Barbus barbus and Barbus meridionalis
Poncin, Pascal ULg; Jeandarme, J.; Berrebi, P.

in Journal of Fish Biology (1994), 45

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See detailAnalyses de sols et gestion de l'espace
Bock, Laurent ULg

in Etude et Gestion des Sols (1994), 1(1), 23-33

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See detailThe experience of radical prostatectomy for locally confined prostate cancer in Liege.
Bouffioux, Christian ULg; de Leval, Jean ULg; Andrianne, Robert ULg et al

in Acta Urologica Belgica (1994), 62(1), 51-9

The authors report their experience of 148 radical prostatectomies performed for adeno-carcinoma. They expose the reasons which have led them to adopt this kind of treatment and the reasons explaining a ... [more ▼]

The authors report their experience of 148 radical prostatectomies performed for adeno-carcinoma. They expose the reasons which have led them to adopt this kind of treatment and the reasons explaining a nearly exponential increase of the frequency of the operation during the last 5 years. They underline the importance of lymphadenectomy and the safety of frozen sections of the nodes. The surgical technique is briefly commented and the (low) morbidity of the operation is reviewed. They compare the results of RPV to those of external radiotherapy, watchful attitude or immediate hormonal treatment and they conclude in insisting on the benefit of the surgical approach as far as indications (which are defined) are strictly followed. [less ▲]

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See detailLe passage à la paternité: une approche clinique
Naziri, Despina ULg; Dragonas, Th.

in Psychiatrie de l'Enfant (La) (1994), 37(2), 601-629

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See detailAssignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4
Marine, Jean-Christophe; Bellefroid, Eric J.; Bourguignon, Catherine et al

in Genomics (1994), 21(1), 285-6

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See detailLa monadologie, une théorie de la communication basée sur l'opacité?
Bouquiaux, Laurence ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994)

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See detail2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle; Dive, Georges ULg; Delaude, Clément et al

in Phytochemistry (1994), 35(2), 533-536

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based ... [more ▼]

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests. [less ▲]

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See detailFactors influencing between-laboratory variability of C-reactive protein results as evidenced by the Belgian External Quality Assessement (EQA) Scheme
Devleeschouwer, N.; Libeer, J. C.; Chapelle, Jean-Paul ULg et al

in Scandinavian Journal of Clinical & Laboratory Investigation (1994), 54(6), 435-40

Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using ... [more ▼]

Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using homogeneous systems with several calibration points generally achieved better performance. Working temperatures influenced the results to a lesser extent. The present study stresses the importance for EQA organizers to collect more detailed information about CRP analytical methods used by the participants. It also suggests that manufacturers should be more involved in the management of quality, in particular by striving for standardization of the material (kit and calibrator) they produce for CRP assay. [less ▲]

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See detailA comparative study of reporter gene activities in fish cells and embryos
Sekkali, B.; Hellemans, B.; Belayew, A. et al

in Molecular Marine Biology and Biotechnology (1994), 3

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See detailThe Dissociative Electroionization of C2H2, C2D2 and C2HD. Investigation of the [C2H(D)]+ and [H(D)]+ Dissociation Channels. The (D)H-C2H(D) binding energy.
Davister, M.; Locht, Robert ULg

in Chemical Physics (1994), 189

The dissociative electroionization of C2H2 in the H+ and C2H+ dissociation channels has been extensively investigated in C2H2 and C2D2. The kinetic energy distributions and ionization efficiency curves of ... [more ▼]

The dissociative electroionization of C2H2 in the H+ and C2H+ dissociation channels has been extensively investigated in C2H2 and C2D2. The kinetic energy distributions and ionization efficiency curves of both species were examined in detail. The H(D)+ ion shows its lowest onset energy at 18.93+/-0.2 eV whereas the C2H+ is produced at 17.30+/-0.11 eV. For the H+-producing channel the kinetic energy (KE) versus the appearance energy (AE) diagram is obtained, extensively discussed and the bond dissociation energy D(H-C2H)= 5.33+/-0.23 eV is estimated. This value is compared and discussed with respect to the values found in the literature. Predissociation and dissociative autoionization are the dominant H+-producing mechanisms. At high electron energies doubly ionized states of C2H2 are involved. For C2H+, beside the threshold at 17.30+/0.11 eV a new onset at 18.27+/0.10 eV is observed. The ionization efficiency of the doubly ionized molecular ion is observed for the first time in C2HD isotopic species. [less ▲]

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See detailSpecific DNA probes to detect Escherichia coli strains producing cytotoxic necrotising factor type 1 or type 2
Oswald, E.; Pohl, P.; Jacquemin, E. et al

in Journal of Medical Microbiology (1994), 40

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See detailLes dommages dus aux plans et leur indemnisation dans le cadre du CWATUP
Delnoy, Michel ULg

in Aménagement - Environnement (1994), 3

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See detailBénard-Marangoni instability in a viscoelastic Jeffreys' fluid layer
Lebon, Georgy ULg; Parmentier, Patrice; Teller, O. et al

in Rheologica Acta (1994), 33(4), 257-266

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See detailWorking memory in Down's syndrome: Training the rehearsal strategy
Comblain, Annick ULg

in Down's Syndrome, Research and Practice : The Journal of the Sarah Duffen Centre (1994), 2(3), 123-126

This study reports on the verbal short term memory skills of individuals with Down's syndrome and on the possibility of increasing memory span durably by using a rehearsal strategy

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See detailANOMALOUS PERTURBATIVE TRANSPORT IN TOKAMAKS DUE TO DRIFT-ALVEN-WAVE TURBULENCE
Thoul, Anne ULg; SIMILON, P. L.; SUDAN, R. N.

in Physics of Plasmas (1994), 1(3), 601-608

The method developed in Thoul, Similon, and Sudan [Phys. Plasmas 1, 579 (1994)] is used to calculate the transport due to drift-Alfven-wave turbulence, in which electromagnetic effects such as the ... [more ▼]

The method developed in Thoul, Similon, and Sudan [Phys. Plasmas 1, 579 (1994)] is used to calculate the transport due to drift-Alfven-wave turbulence, in which electromagnetic effects such as the fluttering of the magnetic field lines are important. Explicit expressions are obtained for all coefficients of the anomalous transport matrix relating particle and heat fluxes to density and temperature gradients in the plasma. Although the magnetic terms leave the transport by trapped electrons unaffected, they are important for the transport by circulating electrons. [less ▲]

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See detailModification of immunoreactive EGF receptor after acute tubular necrosis induced by tobramycin or cisplatin
Leonard, I.; Zanen, J.; Nonclercq, D. et al

in Renal Failure (1994), 16(5), 583-608

Acute tubular necrosis induced by aminoglycoside antibiotics and various other nephrotoxins is followed by a regenerative process which leads to the restoration of damaged tubules. Several lines of ... [more ▼]

Acute tubular necrosis induced by aminoglycoside antibiotics and various other nephrotoxins is followed by a regenerative process which leads to the restoration of damaged tubules. Several lines of evidence indicate that tubular regeneration is mediated by polypeptide growth factors such as epidermal growth factor (EGF). Previous studies devoted to cisplatin nephrotoxicity have shown that this agent causes tubular cystic degeneration possibly related to an impairment of renal tissue repair. Thus, we examined on a comparative basis the time course of the regenerative response subsequent to tubular damage induced by tobramycin or cisplatin, particular attention being paid to renal EGF and its receptor. Female Sprague-Dawley rats (160-180 g body weight) were treated during 4 consecutive days with daily doses of 200 mg/kg tobramycin i.p. (BID) or 2 mg/kg cisplatin (once a day). Sham-treated rats were given 0.9% NaCl i.p. following the same protocol. Groups of experimental animals (n = 5-10) were terminated at increasing time intervals (1, 4, 7, 14, 21, 60 days) after cessation of treatment. One hour prior to sacrifice, each individual received i.p. 200 mg/kg 5-bromo-2'-deoxyuridine (BrdU) for the immunohistochemical demonstration of cell proliferation. Blood was collected at the time of sacrifice in order to assess glomerular filtration rate by measuring serum creatinine and BUN levels. Kidneys were analyzed with respect to total EGF determined by RIA in renal tissue homogenates, and soluble EGF was assayed in extracts prepared by centrifugation. Renal tissue was processed for the immunohistochemical detection of S-phase cells, of EGF, of EGF receptors, and of the intermediate filament vimentin, the latter being used as a marker of epithelium dedifferentiation. In absence of nephrotoxic alterations, EGF was immunolocalized in distal tubules, whereas EGF receptor immunostaining was seen in proximal tubules cells. Vimentin immunostaining was confined to glomeruli and blood vessels. Tobramycin and cisplatin caused acute tubular necrosis in proximal convoluted tubules and proximal straight tubules, respectively. Tissue damage was accompanied by renal dysfunction reflected by an elevation of serum creatinine and BUN levels. Tubular necrosis was followed by a proliferative response indicative of tubular regeneration. Regenerative hyperplasia was associated with a reduction of total immunoreactive EGF due to a decrease of tissue-bound proEGF. Tubules undergoing regenerative repair were characterized by a disappearance of EGF receptors and the presence of immunoreactive vimentin. In tobramycin-treated rats, renal dysfunction lasted for 4-7 days and was fully reversible, as indicated by the return of serum markers to normal values. [less ▲]

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See detailPole, albedo and shape of the minor planets 624 Hektor and 43 Ariadne: Two tests for comparing four different pole determination methods
Detal, Alain ULg; Hainaut, O.; Pospieszalska-Surdej, A. et al

in Astronomy and Astrophysics (1994), 281

Asteroids 624 Hektor and 43 Ariadne have been observed photometrically at the European Southern Observatory (La Silla, Chile) in order to determine their pole orientation. The lightcurves (1984 and 1991 ... [more ▼]

Asteroids 624 Hektor and 43 Ariadne have been observed photometrically at the European Southern Observatory (La Silla, Chile) in order to determine their pole orientation. The lightcurves (1984 and 1991 oppositions for Hektor, and 1985 for Ariadne) are presented. Some of the traditional pole determination methods have been improved, and completely original ones have been developed. They are described and applied to the newly recorded and previously published light curves. The results are commented and compared with previous ones. In addition to the pole orientation, we also derive some information on the shape or the albedo distribtuion of the objects. With the aim of optimizing future observations of these asteroids, we present some graphs showing the best longitudes where they should be measured. Finally, we suggest some improvements in the pole determination and modeling methods based upon photometric data. [less ▲]

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See detailMacrofagos y factor de necrosis tumoral alfa en la necrolisis epidermica toxica
Paquet, Philippe ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Archives of Dermatology (1994), 5

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular ... [more ▼]

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular inflamatorio varió dependiendo del estado de la enfermedad. La principal característica constante fue la importante implicación de la línea monocito-macrófago, incluyendo dendrocitos factor XIIIa+ HLA-DR+ y macrófagos CD68+ Mac 387+, antes y durante la necrosis epidérmica. El número de linfocitos CD4+ y CD8+ era comparativamente reducido. Ello se asociaba con un denso marcaje para el factor de necrosis tumoral alfa en la epidermis. CONCLUSIONES: Las células de estirpe monocito-macrófago superan en nùmero ampliamente a los linfocitos en las lesiones de la necrólisis epidérmica tóxica. El factor de necrosis tumoral alfa es problablemente una de las citocinas principales responsables de la necrosis. [less ▲]

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See detailAspects of the ecology of the wood-inhabiting fungi of Laing Island (Papua New Guinea)
Castillo Cabello, Gabriel ULg; Demoulin, Vincent ULg

in Belgian Journal of Botany (1994)

Dans le cadre d'une étude sur l'écologie des champignons lignicoles de l'île de Laing (Papouasie Nouvelle-Guinée), les espèces les plus fréquemment rencontrées (en particulier: Schizophyllum commune ... [more ▼]

Dans le cadre d'une étude sur l'écologie des champignons lignicoles de l'île de Laing (Papouasie Nouvelle-Guinée), les espèces les plus fréquemment rencontrées (en particulier: Schizophyllum commune, Daldinia eschscholzii et Trametes scabrosa) ont été cartographiées. Les résultats montrent qu'il existe une bonne corrélation entre le type de répartition des champignons et le degré de couverture végétale. In the framework of a study of the ecology of wood-inhabiting fungi on Laing Island (Papua New-Guinea), the most frequently occurring species (namely Schizophyllum commune, Daldinia eschscholzii and Trametes scabrosa) were mapped. The results show a good correlation between the distribution of the fungi and the degree of vegetation cover. [less ▲]

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See detailGender and diagnostic performance of the growth hormone response to clonidine for major depression : A large scale multicenter study
Schittecatte, Michel; Charles, Gerard; Machowski, R. et al

in American Journal of Psychiatry (The) (1994)

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See detailVaricelle létale. Etude immunohistochimique et par hybridation in situ
Nikkels, Arjen ULg; Delvenne, Philippe ULg; Sadzot-Delvaux, Catherine ULg et al

in Annales de Dermatologie et de Vénéréologie (1994), 121(2), 113-117

We report a case of lethal varicella developed in an immunocompromised man in his seventies. A study by immunohistochemistry and in situ hybridization was conducted revealing the presence of the ... [more ▼]

We report a case of lethal varicella developed in an immunocompromised man in his seventies. A study by immunohistochemistry and in situ hybridization was conducted revealing the presence of the glycoprotein gpI specific for VZV and its corresponding nucleic acids found in multiple foci of most tissues and organs, except in the brain and paravertebral sympathetic ganglia. [less ▲]

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See detailExperimental Models of Inflammatory Bowel Disease
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1994), 57(5-6, Sep-Dec), 306-9

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced ... [more ▼]

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced models. Spontaneous models are infectious, genetic or of unknown etiology. Induced models are infectious, immune-mediated, chemical or genetic. All these models share some characteristics with IBD. In general, they are characterized by a chronic inflammation of the gut, and often, this inflammation appears secondary to mucosal abnormalities leading to an abnormal immune and inflammatory response toward luminal material. The most interesting models are thus those that share not only clinical and pathological characteristics with IBD, but also early mucosal abnormalities. From that point of view, the nonsteroidal anti-inflammatory drug (NSAID) enteropathy is probably one of the most interesting model for Crohn's disease (CD). In effect, this model shares an early modification with CD, that is increased intestinal permeability. In animals NSAID enteropathy, the increased intestinal permeability appears early after NSAID administration and is followed by inflammatory lesions. These lesions seem to be secondary to the increased permeability and depend on intraluminal materials, such as alimentary antigens or bacterial fragments. A possible link between the increased permeability and the inflammatory lesions could be an abnormal immune and inflammatory response toward the intraluminal materials. If the increased intestinal permeability in CD was confirmed, the same mechanisms could be implicated in its pathophysiology. [less ▲]

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See detailInvolvement Of The Cyclic Amp-Responsive Element-Binding Protein In Bovine Leukemia-Virus Expression In-Vivo
Adam, E.; Kerkhofs, P.; Mammerickx, M. et al

in Journal of Virology (1994), 68(9),

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See detailTransient hypersensitivity to apomorphine-induced gnawing after termination of acute effects high dose of cocaine
Tirelli, Ezio ULg; Witkin, J. M.

in Behavioural Pharmacology (1994), 5(3), 289-298

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from ... [more ▼]

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from brain and the BEs of COC had dissipated (2 hrs and 4 hrs after administration), effects of AP on gnawing were increased 4-fold. This dopaminergic hypersensitivity (DA-H) was induced by acute treatment with doses of 15 mg/kg COC and higher. Effects of AP were not enhanced 6-24 hrs after COC, indicating a rapid waning of the DA-H. Hypersensitivity to AP (AP-H) was not further augmented by 8 days of daily COC injections. COC did not influence climbing and hypomotility induced by AP 4 hrs after its injection, demonstrating selectivity in the BEs of the DA-H. Further, COC did not induce sensitization to its own effects, indicating that the AP-H was not due to a typical sensitization phenomenon. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailCircadian rhythms and the induction of flowering in the long-day grass Lolium temulentum L.
Périlleux, Claire ULg; Bernier, Georges ULg; Kinet, Jean Marie

in Plant, Cell & Environment (1994), 17(6), 755-761

Plants of Lolium temulentum L. strain Ceres were grown in 8-h short day (SD) for 45 d before being exposed either to a single long day (LD) or to a single 8-h SD given during an extended dark period. For ... [more ▼]

Plants of Lolium temulentum L. strain Ceres were grown in 8-h short day (SD) for 45 d before being exposed either to a single long day (LD) or to a single 8-h SD given during an extended dark period. For LD induction, the critical photoperiod was between 12 and 14 h, and more than 16 h were needed for a maximal flowering response. During exposure to a single 24-h LD, the translocation of the floral stimulus began between the fourteenth and the sixteenth hours after the start of the light period, and was completed by the twenty-fourth hour. Full flowering was also induced by one 8-h SD beginning 4 or 28 h after the start of a 40-h dark period, i.e. by shifting 12 h forward or beyond the usual SD. The effectiveness of a so-called 'displaced short day' (DSD) was not affected by light quality and light intensity. With a mixture of incandescent and fluorescent lights at a total photosynthetic photon flux density of 400 µmol m-2 s-1, a 4-h light exposure beginning 4 h after the start of a 40-h dark period was sufficient to induce 100 flowering. The flower-inducing effect of a single 8-h DSD was also assessed during a 64-h dark period. Results revealed two maxima at a 20-h interval. This fluctuation in light sensitivity suggests that a circadian rhythm is involved in the control of flowering of L. temulentum. [less ▲]

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See detailSuccessful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC).
Snoeck, R.; Andrei, G.; Gerard, Marie-Christine ULg et al

in Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America (1994), 18(4), 570-8

The acyclic nucleoside phosphonate (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was used topically for the treatment of persistent mucocutaneous infections in two cases. One patient with ... [more ▼]

The acyclic nucleoside phosphonate (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was used topically for the treatment of persistent mucocutaneous infections in two cases. One patient with AIDS suffered from a perineal lesion due to infection with herpes simplex virus type 2 (HSV-2) and did not respond to acyclovir and was intolerant of foscarnet. A bone marrow transplant recipient developed orofacial lesions due to infection with herpes simplex virus type 1 (HSV-1) that failed to respond to therapy with both acyclovir and foscarnet. After topical application of HPMPC, the HSV-2 lesions completely resolved. However, the lesions recurred 3 weeks later, and, upon subsequent treatment with HPMPC, regressed. On recurrence, the virus was found to be sensitive to acyclovir, which the patient was given. Again HSV-2, which was resistant to acyclovir, emerged; similar observations were made after another cycle of HPMPC therapy. The HSV-1 isolates were resistant to acyclovir and foscarnet. Following local HPMPC treatment, the lesions regressed, but after 1 week, a second course of topical HPMPC therapy had to be instituted for recurrent infection. The lesions again regressed, and as the recurrent virus was sensitive to acyclovir, the patient was successfully treated with the drug. The results of this study point to the potential usefulness of topical HPMPC in the treatment of immunocompromised patients with HSV-related mucocutaneous infections that are refractory to therapy with acyclovir and/or foscarnet. [less ▲]

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See detailDie Devon/Karbongrenze bei Stockum (Rheinisches Schiefergebirge).
Clausen, C.D.; Korn, D; Feist, R et al

in Geologie und Paläontologie in Westfalen (1994), 29

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See detailCLAY SUPPLIES IN THE CENTRAL INDIAN BASIN SINCE THE LATE MIOCENE - CLIMATIC OR TECTONIC CONTROL
Fagel, Nathalie ULg; DEBRABANT, P.; André, Luc

in Marine Geology (1994), 122(1-2), 151-172

Mineralogical (X-ray diffraction, differential thermal analysis), geochemical [microprobe, inductively coupled plasma (ICP)-atomic emission spectrometry, ICP-mass spectrometry] and Sr-Nd isotopic analyses ... [more ▼]

Mineralogical (X-ray diffraction, differential thermal analysis), geochemical [microprobe, inductively coupled plasma (ICP)-atomic emission spectrometry, ICP-mass spectrometry] and Sr-Nd isotopic analyses have been carried out on the clay size fraction of Late Miocene to Pleistocene sediments from the Central Indian Basin. The samples were taken from five giant cores recovered between 1-degree and 10-degrees-S on a transect along 80-degree-E. The clay assemblages are homogeneous and characterized by an alteration of illite- and smectite-rich levels. Most of the clays are detrital and were derived from a unique source: the weathering of the Indo-Gangetic Plain supplied most of the eroded material. Temporal clay mineralogical fluctuations in the depositional basin reflect environmental changes in the provenance. On the basis of spectral analyses of a mineralogical parameter (peak height ratios), the fluctuating smectite-illite clay sedimentation is controlled by periodic Late Miocene climatic changes. During the Late Pliocene, an irregular, probably tectonic, control appeared. [less ▲]

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See detailIncidence des aménagements hydrauliques sur le contrôle du développement de la bilharziose (shistosomiase)
Pliez, A.; Moens, R.; Debouche, Charles ULg

in Annales de Gembloux (1994), (100), 53-65

Le développement des irrigations dans les zones tropicales et subtropicales du monde, pour augmenter les productions de nourriture, a provoqué la prolifération de maladies liées à l'eau comme la ... [more ▼]

Le développement des irrigations dans les zones tropicales et subtropicales du monde, pour augmenter les productions de nourriture, a provoqué la prolifération de maladies liées à l'eau comme la bilharziose (également appelée shistosomiase), la dengue, la filariose et l'onchocercose. [less ▲]

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See detailStereoelectronic properties of five anti-HSV-1 2′-deoxynucleosides analogues with heterocyclic substituents in the 5-position: A comparison with BVDU
Olivier, Anne; Creuven, Isabelle; Evrard, Christine ULg et al

in Antiviral Research (1994), 24

Structural and electronic characteristics of 5-(5-chlorothien-2-yl)-2′-deoxyuridine (I), 5-(furan-2-yl)-2′-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2′-deoxyuridine (III), 5-(3-bromoisoxazol-5-yl)-2′ ... [more ▼]

Structural and electronic characteristics of 5-(5-chlorothien-2-yl)-2′-deoxyuridine (I), 5-(furan-2-yl)-2′-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2′-deoxyuridine (III), 5-(3-bromoisoxazol-5-yl)-2′-deoxyuridine (V) and 5-(isoxazol-5-yl)-2′-deoxyuridine (IV) have been determined and compared to the BVDU (VI) characteristics in order to explain their respective affinity for the herpes simplex virus type 1 thymidine kinase (TK). Molecular structure of 5-(5-chlorothien-2-yl)-2′-deoxyuridine has been obtained using single crystal X-ray crystallography. Electrostatic potential maps, energy and topology of frontier orbitals were computed at the ab initio MO STO-3G and STO-3G* level. These studies reveal that the electrostatic potential energy maps are clearly dependent on the affinity of the compound for the enzyme. [less ▲]

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See detailVibration amplitudes caused by parametric excitation of cable stayed structures
Lilien, Jean-Louis ULg; Pinto da Costa, Antonio

in Journal of Sound & Vibration (1994), 174(N°1), 69-90

This paper deals with one kind of cable vibrations : the ones caused by parametric excitation.

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See detailExpression of intron-encoded maturase-like polypeptides in potato chloroplasts.
du Jardin, Patrick ULg; Portetelle, Daniel ULg; Harvengt, Luc et al

in Current Genetics (1994), 25(2), 158-163

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See detailEloge de Marcel Migeotte (1912-1992)
Biémont, Emile ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1994), V(6), 271-278

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See detailProtection du vendeur : les garanties légales et conventionnelles
Gosselin, Antoinette ULg

in Actualités du Droit (1994), (4), 933-972

The contribution envisages the protection of the seller as part of the cession of a firm in return for remuneration, giving rise to the payment of a price in exchange for the transfer of ownership. Sale ... [more ▼]

The contribution envisages the protection of the seller as part of the cession of a firm in return for remuneration, giving rise to the payment of a price in exchange for the transfer of ownership. Sale can concern a business or a number of actions or parts representative of an important party of the capital allowing to acquire the control of the society. The first party examines the lawful protection of the giving up, the second conventional guarantees in which giving it up can think to protect itself against the nonpayment of price by the seller. [less ▲]

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See detailApports et limites de trois approches courantes des associations
Defourny, Jacques ULg

in Coopératives et Développement (1994), 26(1), 81-101

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See detailMicrostructural study of a zinc-aluminium-copper alloy after thermal treatment at 100°C and creep
Terziev, L.; Lecomte-Beckers, Jacqueline ULg; Wegria, J.

in Zeitschrift für Metallkunde (1994), 85[9]

The creep behaviour of the ternary Zn—A1—Cu alloy after thermal treatment at ioo oc has been studied. The applied creep stress does flot modify clearly the transition phases (OL, T% ‘11m) appearing during ... [more ▼]

The creep behaviour of the ternary Zn—A1—Cu alloy after thermal treatment at ioo oc has been studied. The applied creep stress does flot modify clearly the transition phases (OL, T% ‘11m) appearing during isothermal ageing. During the creep test, the formation of an important density of defects resuits in the precipitation of T’ and O’ particles. The quantity of these phases depends on the creep conditions. [less ▲]

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See detailAttenuation Of Bovine Leukemia-Virus By Deletion Of R3 And G4 Open Reading Frames
Willems, Luc ULg; Kerkhofs, P.; Dequiedt, Franck ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1994), 91(24),

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See detailTypage moléculaire de Clostridium perfringers.
Daube, Georges ULg; Simon, P.; Limbourg, B. et al

in Annales de Médecine Vétérinaire (1994), 138

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See detail3D turbulence field on the north-western european continental-shelf
Martin, Géraldine ULg; Delhez, Eric ULg

in Tellus : Series A (1994), 46(2), 98-112

The 3-dimensional, non-linear, baroclinic, GHER mathematical model for the study of mesoscale motions (time scale of several hours to several days: tides, storm surges, ...) is described. Particular ... [more ▼]

The 3-dimensional, non-linear, baroclinic, GHER mathematical model for the study of mesoscale motions (time scale of several hours to several days: tides, storm surges, ...) is described. Particular attention is paid to the turbulent closure based on an evolution equation for the turbulent kinetic energy and a parametric expression of the mixing length (k-model). Appropriate boundary conditions and numerical techniques (mode-splitting, implicity, sigma-coordinate system, advection scheme) are described. The model is applied to the simulation of the M2 tide on the North-Western European Continental Shelf not only without wind but also in typical winter and summer conditions. Large spatial variations of the turbulent kinetic energy appear as a result of the variations of depth and tidal activity around the shelf. These variations are clearly related to the different turbulence regimes observed in summer, with frontal structures separating well-mixed waters from stratified ones. The structure and evolution of the vertical profiles of turbulence variables are described and explained in barotropic and baroclinic conditions, under different wind forcings. The evolution of these profiles at the M2 tide frequency largely depends on the eccentricity of the tidal ellipse. [less ▲]

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See detailGénétique moléculaire des récepteurs olfactifs
Parmentier, M.; Vanderhaeghen, P.; Schurmans, Stéphane ULg et al

in Medecine Sciences : M/S (1994), 10

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des ... [more ▼]

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des récepteurs à sept passages transmembranaires couplés, par l'intermédiaire de protéines G, à l'activation de l'adénylyl cyclase et de la phospholipase C. La grande diversité des récepteurs olfactifs réside surtout dans les domaines transmembranaires III, IV, V et VI, qui portent les sites de liaison des ligands, les molécules odorantes, et répond sans doute à la diversité des ligands [less ▲]

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See detailComment on the paper "Oscillator Strengths for Some Systems with the ns2np ground-state configuration: II. Gallium Isoelectronic Sequence
Biémont, Emile ULg; Marcinek, R.; Migdalek, J. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1994), 27

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See detailResonance transitions in Neutral Chlorine
Biémont, Emile ULg; Gebarowski, R.; Zeippen, C. J.

in Astronomy and Astrophysics. Supplement Series (1994), 287

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See detailSelective Antiprotozoal Activity of Some Strychnos Alkaloids
Wright, Colin; Allen, David; Cai, Ya et al

in Phytotherapy Research (1994), 8

The in vitro activities of 28 Strychnos alkaloids have been determined against three species of protozoa and the most active compounds were then assessed for in vitro cytotoxic activity against KB cells ... [more ▼]

The in vitro activities of 28 Strychnos alkaloids have been determined against three species of protozoa and the most active compounds were then assessed for in vitro cytotoxic activity against KB cells. 3',4'-dihydrousambarensine was the most active against Plasmodium falciparum and was relatively nontoxic to KB cells (cytotoxic/antiplasmodial ratio, 1474). Usambarensine displayed the most selectivity against Entamoeba histolytica while "',4'-dihydrousambarensine was the most selective compound against Giardia intestinalis although the cytotoxic/antiprotozoal ratios (20.4 and 6.6 respectively) were less favourable than the above.The four strychnobiline-type alkaloids were found devoid of activity against E. histolytica and G. intestinalis but to have weak antiplasmodial properties (7-13 times less active than chloroquine). None of the compounds containing only one indole ring system displayed antiprotozoal properties. [less ▲]

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See detailAnticorps anticytoplasme des polynucléaires neutrophiles (ANCA) dans les maladies inflammatoires du tube digestif
Lamproye, Anne ULg; Belaiche, Jacques ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (1994), 57(2, Mar-Apr), 171-6

Antineutrophil cytoplasmic antibodies have recently been demonstrated in sera of patients with inflammatory bowel disease. We are reporting here our experience among 94 patients with Crohn's disease and ... [more ▼]

Antineutrophil cytoplasmic antibodies have recently been demonstrated in sera of patients with inflammatory bowel disease. We are reporting here our experience among 94 patients with Crohn's disease and 25 with ulcerative colitis. The indirect immunofluorescence assay with alcohol fixed neutrophils has been used. The presence of antineutrophil cytoplasmic antibodies was significantly associated to the ulcerative colitis 61% VS 17% (p < 0.001). The fluorescence had a perinuclear pattern among all but one suffering from ulcerative colitis. Among the patients suffering from ulcerative colitis there was no relationship between the presence of antineutrophil cytoplasmic antibodies and the activity or the localisation of the disease. Among the 9 patients operated for their ulcerative colitis, 4 were ANCA positive and remained so after proctocolectomy. The existence of antineutrophil cytoplasmic antibodies is useful for the diagnosis of some unclassifiable colitis. Their presence may be used as an argument in favour of some disturbances of the immunoregulation of the disease. [less ▲]

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See detailModulation of the acetylcholine- and substance P-induced pulmonary edema by calcitonin gene-related peptide in the rabbit.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Journal of Pharmacology and Experimental Therapeutics (The) (1994), 270(1), 30-6

The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the ... [more ▼]

The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the arterial, capillary and venous pressures and the capillary filtration coefficient (Kf,c). CGRP was administered alone or in combination with capsaicin (10(-4) M), acetylcholine (ACh) (10(-11) M to 10(-7) M), substance P (SP) (10(-10) M to 10(-6) M) and serotonin (10(-4) M). The influence of a specific antagonist of CGRP receptors, CGRP8-37 (10(-8) M), on the pulmonary edema induced by these mediators was also considered. CGRP had no direct effect on the vascular pressures or on Kf,c. Capsaicin and serotonin induced an increase in Kf,c of 271 +/- 49% and 676 +/- 147% of base line, respectively. ACh and SP also increased the microvascular permeability, in proportion to the concentration. The effects of capsaicin, ACh and SP have been related to the activation of neurokinin NK1 receptors. Co-administration of CGRP with capsaicin and ACh enhanced the increase in Kf,c induced by these two drugs. By contrast, when co-injected with SP, CGRP inhibited the Kf,c increase induced by 10(-8) M and 10(-7) M of SP (P < .05) and significantly decreased the arterial and capillary pressures. CGRP also partly prevented the pulmonary edema induced by serotonin (P < .05). Pretreatment with CGRP8-37 partly prevented the effects of capsaicin and ACh on Kf,c but bestowed no protection against SP-induced pulmonary edema. These data suggest that CGRP is co-released with SP from the C-fibers upon the action of capsaicin and ACh in the rabbit lung. Because CGRP potentiated the pulmonary edema induced in capsaicin and ACh, but decreased the effects of SP, we hypothesize that CGRP exerts a positive retro-control on the release of neuropeptides by these fibers but can attenuate their effects on the target cells. [less ▲]

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See detailSpecific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.
Laptev, A. V.; Lu, Z.; Colige, Alain ULg et al

in Biochemistry (1994), 33(36), 11033-9

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system ... [more ▼]

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system consisted of mouse NIH 3T3 fibroblasts that were stably transfected with a human minigene for procollagen I so that the cells simultaneously synthesized full-length mouse pro alpha 1 (I) chains and internally deleted human pro alpha 1 (I) chains. The sequences of the transcripts from both genes were compared, and a series of 28 ASOs were designed to target sites in which there were at least two base differences within a 20-nucleotide sequence between the human and mouse transcripts. Six of the ASOs specifically decreased the levels of pro alpha 1 (I) chain synthesized from the human gene without a decrease in the levels of pro alpha 1 (I) chains from the mouse endogenous gene. The most effective ASOs reduced the intracellular levels of human pro alpha 1 (I) chains relative to the mouse pro alpha 1 (I) chains to 37-67% of the control values. Combined addition of two effective ASOs or a second administration of the same effective ASO did not produce any additive effect. The results did not support previous suggestions that the best target sites for ASOs were sequences around initiation codons for translation, at intron-exon boundaries, or in single-stranded loops in hairpin structures. Also, the results did not support previous suggestions that the most effective ASOs are those with the highest affinities for their target sequences. Instead, the most consistent pattern in the data was that the most effective ASOs were those targeted to sequences that were predicted to form clustered double-stranded structures in RNA transcripts. [less ▲]

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See detailEnergy Levels in Ar II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Physical Review. A (1994), 49

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See detailPathogenesis of migraine: the biobehavioural and hypoxia theories reconciled.
Schoenen, Jean ULg

in Acta Neurologica Belgica (1994), 94(2), 79-86

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino ... [more ▼]

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino-vascular system. While this can be found in other headache disorders, the process leading ultimately to trigemino-vascular activation appears to characterize migraine. Between attacks, the migrainous brain has two functional abnormalities: a habituation defect in sensory processing, probably related to dysfunctioning transmitter (serotonin, noradrenaline) systems and a reduced mitochondrial energy reserve. Both abnormalities may be genetically determined and concur to favour biochemical shifts leading to the migraine attack as a primary protective mechanism of the brain. Such a model of migraine pathogenesis reconciles the biobehavioural and hypoxia theories and opens new therapeutic perspectives. [less ▲]

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See detailA complex composed of at least two HeLa nuclear proteins protects preferentially one DNA strand of the simple (gt)n(ga)m containing region of intron 2 in HLA-DRB genes.
Maueler, Winfried; Frank, G.; Muller, Marc ULg et al

in Journal of Cellular Biochemistry (1994), 56(1), 74-85

Electrophoretic mobility shift assays reveal that HeLa nuclear proteins bind fast and with measurable affinity to target DNAs containing mixed simple repetitive (gt)n(ga)m stretches. Preincubation of the ... [more ▼]

Electrophoretic mobility shift assays reveal that HeLa nuclear proteins bind fast and with measurable affinity to target DNAs containing mixed simple repetitive (gt)n(ga)m stretches. Preincubation of the proteins at elevated temperature prevents the formation of the major DNA/protein complex in favour of several distinct assemblies. A similar pattern of retarded bands was observed employing higher salt concentrations in the binding reaction. Thus conformational changes of different proteins appear to influence the complex rather than alternating DNA structures. Separation of the total nuclear extract into a water soluble and an insoluble protein fraction leads to a complete loss of target DNA binding capability of the fractions. The binding capacity is restored by combining the two fractions suggesting that at least two protein components are necessary to form a complex with the target sequence. The proteins can be differentiated into heat sensitive, water soluble and temperature stable, water insoluble, respectively. Furthermore, specifically binding polypeptides are not detectable by Southwestern analyses, probably because the essential components are separated during electrophoresis. DNase I footprint analyses yield four different protein binding regions only on the (gt)n(ga)m harbouring strand. The footprints cover larger portions of the mixed simple repeat in addition to a portion 5' of the (gt)n part. Hence at least two nuclear protein components of unknown biological function have to be present simultaneously to protect preferentially the (gt)n(ga)m-containing strand of intron 2 in HLA-DRB genes. [less ▲]

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See detailLes défis des familles recomposées
Guillaume, Jean-François ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 6(novembre-décembre), 30-36

Dans un contexte de croissance des recompositions conjugales après divorce, la prise en charge des tâches parentales constitue un défi inédit, où il s'agit pour les uns de retrouver des repères bien ... [more ▼]

Dans un contexte de croissance des recompositions conjugales après divorce, la prise en charge des tâches parentales constitue un défi inédit, où il s'agit pour les uns de retrouver des repères bien connus, et pour les autres, d'imaginer un nouvel ordre éducatif. Une nouvelle histoire doit alors être créée, et dans ce "bricolage", chacun ne dispose pas des mêmes ressources pour trouver sa place. [less ▲]

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See detailA Dynamic Stiffness-Transfer Matrix Method for Forced Response Analysis of One-Dimensional Structures
Chen, S. L.; Golinval, Jean-Claude ULg; Géradin, Michel ULg

in Journal of Modal Analysis (1994), (Avril),

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See detailLa Formation de Pepinster dans le Synclinorium de Verviers, entre Perpinster et Eupen (Belgique)-Contexte structural et stratigraphique
Dejonghe, L; Steemans, Philippe ULg

in Annales de la Société Géologique de Belgique (1994), 117

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See detailItinéraire d’une fable : le Loup et le Chien
Pietquin, Paul ULg; Dachy, Françoise; Debrux, Thomas et al

in Etudes Classiques (Namur, Belgium) (1994), 62

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See detailUtilisation des moules comme bioindicateurs de la pollution en métaux lourds du littoral belge
Gobert, Sylvie ULg; Langer, Alain; Daemers-Lambert, Claire et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 203-210

From 1991 till 1993, a study of the Belgian coast pollution by heavy metals using Mytilus edulis as a bioindicator was performed. The Pb, Cr, Cu and Ti concentrations decreased from 1987 till 1991 but ... [more ▼]

From 1991 till 1993, a study of the Belgian coast pollution by heavy metals using Mytilus edulis as a bioindicator was performed. The Pb, Cr, Cu and Ti concentrations decreased from 1987 till 1991 but then remained unchanged till 1993. Cd contamination is increasing from 1987. Hg, whose concentration had been shown to decrease from 1975 to 1991, now reaches the same values as in 1986. The O/N measurements performed on the mussels suggest an increase of the general pollution level of the Belgian coast. However, feeding, spawning and detoxification processes are also able to influence the O/N ratio and should be taken into account in the framework of a global assessment of the pollution level of the Belgian coast [less ▲]

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See detailEpidemiological evaluation of a monoclonal ELISA detecting antibodies against bovine leukaemia virus in serum pools.
Knapen, K.; Kerkhofs, P.; Thiry, Etienne ULg et al

in Epidemiology & Infection (1994), 113(3), 563-9

Sensitivity, specificity and predictive values of an enzyme-linked immunosorbent assay (ELISA) for detecting antibodies against bovine leukaemia virus (BLV) were evaluated using a representative sample of ... [more ▼]

Sensitivity, specificity and predictive values of an enzyme-linked immunosorbent assay (ELISA) for detecting antibodies against bovine leukaemia virus (BLV) were evaluated using a representative sample of 145 serum pools, comprising from 3 to 48 individual sera. The sample was constituted according to the frequency distribution of the negative and positive pools analysed during a screening involving the whole cattle population of Belgium. Sensitivity and specificity were estimated to 88.9% and 100% and the predicted negative and positive values were 99.9% and 100%, respectively. These results indicate the use of serum pools is suitable for the detection of BLV infected herds in eradication campaigns. [less ▲]

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See detailChoix d'une nouvelle variete pour les zones cotonnieres meridionales du Zaire. Resultats des essais varietaux preliminaires.
Mergeai, Guy ULg; Ndungo, V.; Folo, A. et al

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(4),

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See detailLa châsse de saint Remacle à Stavelot : étude des éléments décoratifs
Van den Bossche, Benoît ULg

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Beaux-Arts (1994), V(1-6), 109-149

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See detailRound Table Conference on Mediators of Sepsis--Brussels, Belgium, March 21-23, 1992
Lamy, Maurice ULg; Thijs, L. G.

in Intensive Care Medicine (1994), 20(3), 238-41

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See detailPreservation of Oocyte and Granulosa Cell Morphology in Bovine Preantral Follicles Cultured in Vitro
Figueiredo, J. R.; Hulshof, S. C.; Van den Hurk, R. et al

in Theriogenology (1994), 41(6), 1333-46

Described in the present paper is a culture system that preserves oocyte and granulosa cell morphology in bovine preantral follicles during 5 d in vitro. The effects of additional hypoxanthine and energy ... [more ▼]

Described in the present paper is a culture system that preserves oocyte and granulosa cell morphology in bovine preantral follicles during 5 d in vitro. The effects of additional hypoxanthine and energy substrata (i.e., pyruvate and glutamine) on the morphology of cultured preantral follicles were investigated. It was shown that addition of a mixture of pyruvate, glutamine and hypoxantine to the culture medium increased the percentage of follicles with an intact oocyte from 29.4 to 78.6%. Morphological criteria are described to discriminate between normal and degenerated preantral follicles during culture by inverted microscopy. In addition, the importance of histological evaluation to judge the quality of oocyte and granulosa cells is demonstrated. [less ▲]

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See detailAspects épidémiologiques du suicide
Gosset, Christiane ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 2

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