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See detailEradication de la leucose bovine enzootique en Belgique : estimation du temps nécessaire à l'assainissement des foyers découverts
Knapen, K.; Kerkhofs, P.; Palm, Rodolphe ULg et al

in Annales de Médecine Vétérinaire (1991), 135(4), 281-285

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See detailE1 Transitions of Astrophysical Interest in Neutral Oxygen
Hibbert, A.; Biémont, Emile ULg; Godefroid, M. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1991), 24

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See detailNutritive-Value Of Triticale Cultivars In Pigs As A Function Of Their Chemical-Composition
Leterme, Pascal; Tahon, François; Thewis, André ULg

in Animal Feed Science & Technology (1991), 35(1-2), 49-53

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See detailCloning and nucleotide sequencing of the gene encoding the beta-lactamase from Citrobacter diversus
Perilli, Mariagrazia; Franceschini, Nicola; Segatore, Bernardetta et al

in FEMS Microbiology Letters (1991), 83

The gene coding for the class A beta-lactamase of Citrobacter diversus has been cloned and sequenced. It contains the information for a 294-amino-acid precursor protein, including a 27-residue N-terminal ... [more ▼]

The gene coding for the class A beta-lactamase of Citrobacter diversus has been cloned and sequenced. It contains the information for a 294-amino-acid precursor protein, including a 27-residue N-terminal signal peptide. The deduced sequence of the N-terminal portion of the mature protein is in excellent agreement with that determined by microsequencing of the protein and readily explains the pI differences observed between the naturally occurring forms I and II of the enzyme. The sequence of the mature protein exhibits a very high degree of similarity with that of the Klebsiella oxytoca class A beta-lactamase [less ▲]

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See detailUse Of Synthetic Peptides To Map Sequential Epitopes Recognized By Monoclonal-Antibodies On The Bovine Leukemia-Virus External Glycoprotein
Callebaut, I.; Burny, A.; Krchnak, V. et al

in Virology (1991), 185(1),

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See detailFluorine-18-altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats.
Lemaire, Christian ULg; Cantineau, Robert; Guillaume, Marcel et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1991), 32(12), 2266-72

No-carrier-added [18F]altanserin was synthesized by nucleophilic substitution of the corresponding nitro compound with [18F]fluoride in the presence of kryptofix 222 and K2CO3. After purification by ... [more ▼]

No-carrier-added [18F]altanserin was synthesized by nucleophilic substitution of the corresponding nitro compound with [18F]fluoride in the presence of kryptofix 222 and K2CO3. After purification by preparative HPLC, [18F]altanserin was produced in less than 2 hr with a radiochemical yield of 10% (EOS) and a specific activity of 0.8-1.3 Ci/mumol. In rats, the tracer localized rapidly in the whole brain (0.5% ID/g organ) with a high binding to the frontal cortex. The frontal cortex/cerebellum ratio increased with time and reached a plateau of 11 at 2 hr postinjection. This uptake in S2 receptor regions was saturable and could be blocked by pretreatment with various S2 antagonists. This radiopharmaceutical appears to be more selective for S2 receptor sites than other ligands available today and allows the study of S2 receptors under in vivo conditions. [less ▲]

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See detailRegioselective hydrochlorination of olefins is favored by an acidic solid catalyst
Delaude, Lionel ULg; Laszlo, Pierre ULg

in Tetrahedron Letters (1991), 32(30), 3705-3708

With thionyl chloride SOCl2 as HCl precursor, 1-methylcyclohexene is hydrochlorinated. In the absence of a solid catalyst, between half and two-thirds of the product mixture are the anti-Markovnikov ... [more ▼]

With thionyl chloride SOCl2 as HCl precursor, 1-methylcyclohexene is hydrochlorinated. In the absence of a solid catalyst, between half and two-thirds of the product mixture are the anti-Markovnikov adduct, trans 1-chloro-2-methyl cyclohexane. Catalysis by the ZF 520 zeolite or the K10 montmorillonite makes the reaction selective. It then affords a quantitative yield of (10:1) Markovnikov adduct 1-chloro-1-methylcyclohexane. [less ▲]

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See detailA scoring system in predicting the risk of intestinal stricture in necrotizing enterocolitis
Battisti, Oreste ULg; Evrard, J.; Khamis, J. et al

in European Journal of Pediatrics (1991), 150

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See detailSerine Beta-Lactamases and Penicillin-Binding Proteins
Ghuysen, Jean-Marie ULg

in Annual Review of Microbiology (1991), 45

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See detailManagement of small woods in Belgium.
Rondeux, Jacques ULg

in Quarterly Journal of Forestry (1991), 85(1), 37-42

In Belgium, forest occupies 20 per cent of the total land area. Private forests account for about 52 per cent; they are generally small (averaging about three ha) and their owners are not accustomed to ... [more ▼]

In Belgium, forest occupies 20 per cent of the total land area. Private forests account for about 52 per cent; they are generally small (averaging about three ha) and their owners are not accustomed to basing their decisions on a management plan. However, some attempts to develop co-operation through forestry associations exist and the regional authorities tend to encourage them. Whatever the details of any possible future legislation may be, the principal aim must be the development and introduction of an extremely simple form of management plan (the so-called 'plan simple de gestion') in exchange for assistance to the private owner. [less ▲]

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See detailResting behavior of Friesian bulls 5 and 12 months old in a tie stall barn
Nicks, Baudouin ULg; Dechamps, P.; Canart, B. et al

in World Review of Animal Production (1991), 26

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See detailLa mort en appel. Poétique de l'invocation chez Jacques Derrida
Steinmetz, Rudy ULg

in Art&Fact (1991)

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See detailImmunocytochemical evidence for production of luteinizing hormone and follicle-stimulating hormone in separate cells in the bovine.
Bastings, E.; Beckers, Albert ULg; Reznik, Michel ULg et al

in Biology of Reproduction (1991), 45(5), 788-96

In all mammalian females, follicular growth and maturation are essentially dependent on the pituitary gonadotropins, FSH and LH. These glycoprotein hormones have many similarities, but their action, based ... [more ▼]

In all mammalian females, follicular growth and maturation are essentially dependent on the pituitary gonadotropins, FSH and LH. These glycoprotein hormones have many similarities, but their action, based on high affinity binding to specific membrane receptors, are quite different. The purpose of this study was to perform a sensitive localization of FSH and LH in secretory granules of gonadotrophs using highly specific antisera. This morphological study included light microscopy (PAP) and electron microscopy (immunogold single and double labeling) procedures. Histologically, approximatively 11.5% of cells were positive for LH, whereas only 5.4% of cells were positive for FSH. With the electron microscope, single labeling allowed identification of morphologically distinct LH-containing cells and FSH-containing cells. Double immunostaining confirmed that no cells contained both hormones. The finding that FSH and LH are produced in separate pituitary cells is in agreement with recent studies that have suggested a specific role and regulatory process for gonadotropins in the bovine species. [less ▲]

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See detailComparaison du comportement de repos de taurillons en stabulation libre sur paille et en stabulation entravée
Vandenheede, Marc ULg; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1991), 135

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See detailComparison of the resting behaviour of Friesian and belgian White-blue fattening bulls in a littered loose house and in a stanchion barn
Vandenheede, Marc ULg; Nicks, Baudouin ULg; Dechamps, P. et al

in Applied Animal Behaviour Science (1991), 30(1-2), 183

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See detailAcute effects of Parlodel-LAR and response to long-term treatment with bromocriptine in a patient with a follicle stimulating hormone-secreting pituitary adenoma.
Abs, R.; Parizel, P. M.; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1991), 14(2), 135-8

A 68-year-old male patient presented with visual impairment due to a large pituitary tumor. After transsphenoidal adenomectomy the elevated serum FSH levels were lowered but not normalized. Deterioration ... [more ▼]

A 68-year-old male patient presented with visual impairment due to a large pituitary tumor. After transsphenoidal adenomectomy the elevated serum FSH levels were lowered but not normalized. Deterioration of the vision was detected five years later and tumor regrowth was evidenced. The patient was treated with the long-acting and repeatable form of bromocriptine (Parlodel-LAR). Three days after the first intramuscular injection it already resulted in an important improvement of the visual field defects. Serum FSH concentration was suppressed during a prolonged period, but no change in the size of the pituitary adenoma was recorded on CT scan. Long-term oral treatment with bromocriptine resulted in a sustained suppression of the serum FSH levels, without further visual improvement, but with a significant reduction of the volume of the adenoma. The rapid and prolonged effect of Parlodel-LAR upon the FSH secretion, with a possible correction of the visual field defects and a reduction of the tumor mass, could make this medication appropriate as adjunctive treatment in some gonadotroph cell adenomas. [less ▲]

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See detailRevision of the Structure of Strychnochromine
Quetin-Leclercq, Joëlle; Angenot, Luc ULg; Dupont, Léon et al

in Tetrahedron Letters (1991), 32(34), 4295-4298

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to ... [more ▼]

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to establish the stereochemistry of the compound extensive 2D-NMR experiments were carried out. The COSY experiments mostly confirmed the previous observations but the COLOC maps did not fit the first proposed structure!The problem was solved by single-crystal X-ray analysis of the p-bromobenzoyl ester of strychnochromine. The new structure, with its tetrahydroquinoline ring, is very unusual in Strychnos species but the formation of quinolines from indole alkaloids has already mentioned in some other plants ( Cinchona, Alstonia, Hunteria..). [less ▲]

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See detailStructures du cyclohexyl-1[(cycloheptylamino-4 pyridyl-3)sulfonyl]-3 urée et de l'hydrogénonitrate du cyclohexyl-1[(cyclooctylamino-4 pyridyl-3)sulfonyl]-3 urée
Dupont, L.; Dideberg, O.; Masereel, B. et al

in Acta Crystallographica (1991), C47

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See detailMiscellaneous spectroscopic observations of quasars and quasar candidates
Veron, P.; Veron-Cetty, M.-P.; Djorgovski, S. et al

in Astronomy and Astrophysics. Supplement Series (1990), 86

Spectroscopic observations are presented for 11 quasar candidates, as well as 19 quasars with uncertain redshift, three BL Lac candidates, and 11 objects located within a few arcsec of a quasar. The ... [more ▼]

Spectroscopic observations are presented for 11 quasar candidates, as well as 19 quasars with uncertain redshift, three BL Lac candidates, and 11 objects located within a few arcsec of a quasar. The spectra indicate than nine of the 11 quasar candidates are stars, while the remaining two are low-redshift galaxies. The individual objects studied and commented on include KPNO 1, CFHT 2, Q 0010+023, UM 232, UM 473, WEE 124, UM 644, PKS 1514+197, MC3 1639+155, and WEE 185. [less ▲]

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See detailCatalogue of Lambda Bootis Candidates
Renson, Pierre ULg; Faraggiana, R.; Boehm, C.

in Bulletin d'Information du Centre de Données Stellaires (1990), 38

Not Available

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See detailListe des étoiles Ap et Am dans les amas ouverts (Edition révisée)
Renson, Pierre ULg

in Bulletin d'Information du Centre de Données Stellaires (1990), 38

We give a revised, and more complete, version of the "Catalogue of Ap and Am stars in open clusters given elsewhere (Renson, 1988a).

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See detailCharacterization of an Enterococcus Hirae Penicillin-Binding Protein 3 with Low Penicillin Affinity
Piras, Graziella; El Kharroubi, Aboubaker; van Beeumen, Jozef et al

in Journal of Bacteriology (1990), 172(12), 6856-6862

Enterococcus hirae S185, a clinical isolate from swine intestine, exhibits a relatively high resistance to penicillin and contains two 77-kDa penicillin-binding proteins 3 of high (PBP 3s) and low (PBP 3r ... [more ▼]

Enterococcus hirae S185, a clinical isolate from swine intestine, exhibits a relatively high resistance to penicillin and contains two 77-kDa penicillin-binding proteins 3 of high (PBP 3s) and low (PBP 3r) affinity to penicillin, respectively. A laboratory mutant S185r has been obtained which overproduces PBP 3r and has a highly increased resistance to penicillin. Peptide fragments specifically produced by trypsin and SV8 protease digestions of PBP 3r were isolated, and the amino acid sequences of their amino terminal regions were determined. On the basis of these sequences, oligonucleotides were synthesized and used as primers to generate, by polymerization chain reaction, a 233-bp DNA fragment the sequence of which translated into a 73-amino-acid peptide segment of PBP 3r. These structural data led to the conclusion that the E. hirae PBP 3r and the methicillin-resistant staphylococcal PBP 2' are members of the same class of high-Mr PBPs. As shown by immunological tests, PBP 3r is not related to PBP 3s but, in contrast, is related to the 71-kDa PBP 5 of low penicillin affinity which is responsible for penicillin resistance in E. hirae ATCC 9790 and R40. [less ▲]

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See detailIndications actuelles de la greffe hétérotopique en transplantation cardiaque
RADERMECKER, Marc ULg; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1990), 45(12), 614-9

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See detailAn automatic remeshing processor
Habraken, Anne ULg

in Journal of Materials Processing Technology (1990), 24

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See detailPour une production ligneuse de qualité : impératifs écologiques et sylvicoles.
Baix, Ph.; Dethioux, M.; Rondeux, Jacques ULg

in Agricontact (1990), (223), 1-7

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See detailPlasma renin activity and urine beta 2-microglobulin during and after cardiopulmonary bypass: pulsatile vs non-pulsatile perfusion
Canivet, Jean-Luc ULg; Larbuisson, Robert ULg; Damas, Pierre ULg et al

in European Heart Journal (1990), 11(12), 1079-1082

Fourteen patients with normal preoperative renal function underwent aortocoronary bypass graft using cardiopulmonary bypass (CPB) with pulsatile (P;n = 7) or non pulsatile (NP;n = 7) perfusion. In the two ... [more ▼]

Fourteen patients with normal preoperative renal function underwent aortocoronary bypass graft using cardiopulmonary bypass (CPB) with pulsatile (P;n = 7) or non pulsatile (NP;n = 7) perfusion. In the two groups prebypass values of plasma renin activity (PRA) and urine beta 2-microglobulin (beta 2-M) were within normal limits. PRA increased significantly during CPB and the first 6 h after CPB only in the non-pulsatile group. In both groups, the urine beta 2-M level increased significantly during and after CPB; however, there was no significant difference in urine beta 2-M levels between the two groups. Also, the amount of beta 2-M excreted in urines per unit of time increased significantly in both groups during and after CPB; there was no significant difference between the two groups. [less ▲]

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See detailResponse to Epidermal Growth Factor of Skin Fibroblasts from Donors of Varying Age Is Modulated by the Extracellular Matrix
Colige, Alain ULg; Nusgens, Betty ULg; Lapiere, ChM

in Journal of Cellular Physiology (1990), 145(3), 450-7

The present study was undertaken to investigate the effect of epidermal growth factor (EGF) on the biosynthetic activity of skin fibroblasts from donors of varying age and the modulation of their response ... [more ▼]

The present study was undertaken to investigate the effect of epidermal growth factor (EGF) on the biosynthetic activity of skin fibroblasts from donors of varying age and the modulation of their response to this growth factor by culture in a three-dimensional extracellular matrix. When cultured in monolayer on plastic or at the surface of a collagen gel, EGF specifically inhibited collagen synthesis whatever the age of the donor (from 17 to 84 years, n = 11). This inhibition was paralleled by a significant decrease in the steady-state level of procollagen type I mRNAs. When embedded in a three-dimensional floating collagen lattice, EGF stimulated the non-collagen protein (NCP) synthesis in fibroblasts from younger donors (5 out of 6) while fibroblasts from the older ones were not affected. Collagen production by fibroblasts from younger donors was not inhibited as in monolayer (some being even stimulated) while that of the older donors was inhibited as observed in monolayer. The steady-state level of procollagen type I mRNA was not modified by EGF in the three-dimensional culture. No significant difference was observed in the affinity and the number of EGF receptors of the fibroblasts on plastic or embedded in a collagen lattice between young and aged donors. Our results suggest that the environment of the cells can modulate the reactivity to EGF and reveal differences related to in vivo aging. [less ▲]

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See detailAn automatic remeshing technique for finite element simulation of forming processes
Habraken, Anne ULg; Cescotto, Serge ULg

in International Journal for Numerical Methods in Engineering (1990), 30(8), 1503-1525

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See detailAccuracy in Early Prediction of Prognosis of Patients with Septic Shock by Analysis of Simple Indices: Prospective Study
D'Orio, Vincenzo ULg; Mendes, P.; Saad, G. et al

in Critical Care Medicine (1990), 18(12), 1339-45

In 26 consecutive septic shock patients, we analyzed the clinical, hemodynamic, and metabolic data before and during volume infusion to test their circulatory reserve in response to fluid repletion. These ... [more ▼]

In 26 consecutive septic shock patients, we analyzed the clinical, hemodynamic, and metabolic data before and during volume infusion to test their circulatory reserve in response to fluid repletion. These patients were investigated to identify early variables that could predict outcome. There were 15 survivors (group A) and 11 nonsurvivors (group B). As a mean, group A patients were hemodynamically evaluated 2.3 h after onset of the sepsis syndrome, whereas group B patients underwent cardiac catheterization after a 12-h interval. At the initial evaluation, both groups demonstrated similarly decreased mean arterial pressure, mean heart rate, and mean cardiac filling pressure. Only group A patients evidenced elevated cardiac index (CI) (greater than 4 L/min.m2) associated with low systemic vascular resistance index (less than 7400 dyne.sec/cm5.m2), which is generally recognized as hyperdynamic cardiac state. However, none of the initial cardiovascular variables could serve as a predictor for survival. Fluid challenge increased left ventricular preload from 6 to 12.4 and from 7.8 to 12.7 mm Hg in group A and group B, respectively. The increases were associated with significant increases in CI from 4.4 to 6.9 and from 3 to 3.8 L/min.m2. However, at the end of fluid challenge, only group A patients exhibited normal cardiac response, as evidenced by the change in left ventricular stroke work index (LVSWI) for a given increase in the pulmonary capillary wedge pressure (WP) that was referred to as left cardiac preload.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailDiurnal Rhythmicity in the Pattern of Mrnas in the Leaves of Sinapis Alba
Cremer, Frédéric ULg; Dommes, Jacques ULg; Van de Walle, Claude ULg et al

in Plant Physiology (1990), 94(4), 1590-1597

Previous studies have shown that certain specific leaf mRNAs exhibit a diurnal rhythmicity in their quantity in higher plants. To determine whether this situation is restricted to a few mRNAs, or affects ... [more ▼]

Previous studies have shown that certain specific leaf mRNAs exhibit a diurnal rhythmicity in their quantity in higher plants. To determine whether this situation is restricted to a few mRNAs, or affects a large number, we have used in vitro translation and two-dimensional polyacrylamide gel electrophoresis to analyze the mRNA complement in leaves of Sinapis alba at different times during an 8-hour/16-hour day/night cycle. A method for the visual analysis of two-dimensional polyacrylamide gel electrophoresis was also developed. This method selected, at each sampling time, spots that were significant. It then selected, between two sampling times, intensity changes that were significant at the 0.02 confidence level. During a day/night cycle, complex rhythmic changes affected about 10% of the mRNAs. Nineteen different rhythm patterns were found. These 19 patterns fell into four main classes: mRNAs that increase during the light period and decrease during the dark, mRNAs that increase and then decrease during the light period, mRNAs that decrease during the light period and increase during the dark period, and mRNAs that increase and then decrease during the dark period. [less ▲]

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See detailEffects of the Nonsteroidal Inhibitor R76713 on Testosterone-Induced Sexual Behavior in the Japanese Quail (Coturnix Coturnix Japonica)
Balthazart, Jacques ULg; Evrard, L.; Surlemont, C.

in Hormones & Behavior (1990), 24(4), 510-31

A new triazole derivative, R76713 (6-[4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H- benzotriazole), was recently shown to inhibit aromatase selectively without affecting other steroid ... [more ▼]

A new triazole derivative, R76713 (6-[4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H- benzotriazole), was recently shown to inhibit aromatase selectively without affecting other steroid-metabolizing enzymes and without interacting with estrogen, progestin, or androgen receptors. This compound was tested for its capacity to intefere with the induction of copulatory behavior by testosterone (T) in castrated Japanese quail (Coturnix coturnix japonica). In a first experiment, R76713 inhibited (range 0.01 to 1 mg/kg) the activation of sexual behavior by T silastic implants and hypothalamic aromatase activity in castrated male quail in a dose-dependent manner. The 5 alpha- and 5 beta- reductases of T were not systematically affected. Stereotaxic implantation of R76713 in the medial preoptic area similarly blocked the behavior activated by systemic treatment with T, demonstrating that central aromatization of androgen is implicated in the activation of behavior. These inhibiting effects of R76713 on behavior were observed when implants were placed in the medial part of the nucleus preopticus medialis, confirming the implication of this brain area in the control of male copulatory behavior. Finally, the behavioral inhibition produced by R76713 could be reversed by simultaneous treatment with a dose of estradiol, which was not behaviorally effective by itself. This suggests that the behavioral deficit induced by the inhibitor was specifically due to the suppression of estrogen production. This also shows that the activation of copulatory behavior probably results from the interaction of androgens and estrogens at the brain level, as the two treatments separately providing these hormonal stimuli (T with the aromatase inhibitor on one hand and a low dose of estradiol on the other hand) had almost no behavioral effects but they synergized to activate copulation when given concurrently. These data confirm the critical role of preoptic aromatase in the activation of reproductive behavior and demonstrate that R76713 is a useful tool for the in vivo study of estrogen-dependent processes. [less ▲]

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See detailHeparin-induced thrombocytopenia: A case report
Van Damme, Hendrik ULg; Damas, Pierre ULg; David, Jean-Louis ULg et al

in Angiology (1990), 41(12), 1075-1081

The authors report a case of heparin-induced thrombocytopenia, in whom massive pulmonary embolism occurred in spite of heparin anticoagulation. Successful pulmonary thrombectomy was carried out under ... [more ▼]

The authors report a case of heparin-induced thrombocytopenia, in whom massive pulmonary embolism occurred in spite of heparin anticoagulation. Successful pulmonary thrombectomy was carried out under cardiopulmonary bypass, with limitation of platelet clumping during bypass by aggregation inhibitors. This report is a comprehensive contribution to a better understanding of this rare immunoallergic complication of heparin administration, with a high incidence of serious thromboembolic events. The optimal management for cases of unavoidable reexposure to heparin is discussed. [less ▲]

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See detailNew observations and gravitational lens models of the Cloverleaf quasar H1413 + 117
Kayser, R.; Surdej, Jean ULg; Condon, J. J. et al

in Astrophysical Journal (1990), 364

New optical and radio observations of the quadruple quasar H1413 + 117, the Cloverleaf, are presented. VLA data show radio counterparts at the positions of the four optical images and an additional strong ... [more ▼]

New optical and radio observations of the quadruple quasar H1413 + 117, the Cloverleaf, are presented. VLA data show radio counterparts at the positions of the four optical images and an additional strong radio source between images B and D. Gravitational lens models of H1413 + 117 using (1) a single elliptical galaxy and (2) two spherical galaxies are presented, which fit the positions of the four images of the quasar remarkably well. The models suggest that the strong radio source is a feature of the quasar, e.g., an ejected blob, which lies right on the caustic of the lens and is thereby strongly amplified. The time delays predicted by these models are sufficiently short to allow for their determination within one observational season, making H1413 + 117 an exceptionally well suited object for gravitational lens research. [less ▲]

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See detailSequence of a Lipase Gene from the Antarctic Psychrotroph Moraxella Ta144
Feller, Georges ULg; Thiry, M.; Gerday, Charles ULg

in Nucleic Acids Research (1990), 18(21), 6431

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See detailDistribution of Aromatase in the Brain of the Japanese Quail, Ring Dove, and Zebra Finch: An Immunocytochemical Study
Balthazart, Jacques ULg; Foidart, Agnès ULg; Surlemont, C. et al

in Journal of Comparative Neurology (1990), 301(2), 276-88

An immunocytochemical peroxidase-antiperoxidase procedure using a purified polyclonal antibody raised against human placental aromatase was used to localize aromatase-containing cells in the brain of ... [more ▼]

An immunocytochemical peroxidase-antiperoxidase procedure using a purified polyclonal antibody raised against human placental aromatase was used to localize aromatase-containing cells in the brain of three avian species: the Japanese quail, the ring dove, and the zebra finch. In quail and dove, immunoreactive cells were found only in the preoptic area and hypothalamus, with a high density of positive cells being present in the medial preoptic area, in the septal area above the anterior commissure, in the ventromedial nucleus of the hypothalamus, and in rostral part of the infundibulum. Immunoreactivity was weaker in zebra finches, and no signal could therefore be detected in the ventromedial and tuberal hypothalamus. The positive material was localized in the perikarya and in adjacent cytoplasmic processes, including the full length of axons always leaving a clear unstained cell nucleus. These features could be observed in more detail on sections cut from perfused brains and stained with an alkaline phosphatase procedure. The distribution of aromatase immunoreactivity was similar in the three species although minor differences were observed in the preoptic area. The localization of labelled neurons coincided with the distribution of aromatase activity as studied by in vitro radioenzyme assays on brain nuclei dissected by the Palkovits punch method. There was one striking exception to this rule: no immunoreactivity was detected in the zebra finch telencephalon, while assays had shown the presence of an active enzyme in several nuclei such as the robustus archistriatalis, the hyperstriatum ventrale pars caudale, and the hippocampus and area parahippocampalis. The origins of this discrepancy and the functional role of the aromatase observed in the axons are discussed. [less ▲]

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See detailManipulation photopériodique des saisons de reproduction chez le barbeau (Barbus barbus)
Poncin, Pascal ULg; Castelli, M.

in Cahiers d'Ethologie (1990), 10(3-4), 447-450

Pendant deux ans nous avons soumis quatre lots expérimentaux de barbeaux mâles et femelles d'élevage à différentes photopériodes artificielles, permettant une production quasi continue de larves. Celles ... [more ▼]

Pendant deux ans nous avons soumis quatre lots expérimentaux de barbeaux mâles et femelles d'élevage à différentes photopériodes artificielles, permettant une production quasi continue de larves. Celles-ci ont été élevées en eau réchauffée et utilisées pour l'expérimentation en génétique, le repeuplement des rivières et la commercialisation. [less ▲]

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See detailThe latitudinal gradient of the NO peak density
Fesen, C. G.; Rusch, D. W.; Gérard, Jean-Claude ULg

in Journal of Geophysical Research (1990), 95

Results are presented from SME observations of the latitudinal gradients of peak NO densities at about 110-km altitude during the solstice and equinox periods from 1982 through 1985. It is shown that the ... [more ▼]

Results are presented from SME observations of the latitudinal gradients of peak NO densities at about 110-km altitude during the solstice and equinox periods from 1982 through 1985. It is shown that the response of the peak NO densities to the declining level of solar activity varies with latitude, with the polar regions exhibiting low sensitivity and the low-latitude regions responding strongly. The SME data also revealed marked asymmetries in the latitudinal structure of the two hemispheres for each season and considerable day-to-day variations in the NO densities. The solar cycle minimum data for June were simulated using a two-dimensional model; results of sensitivity studies performed with varied quenching rate and eddy diffusion coefficient are presented. [less ▲]

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See detailBeta-lactamase expression in Streptomyces cacaoi
Urabe, Hiroaki; Lenzini, Mauro V; Mukaide, Masakazu et al

in Journal of Bacteriology (1990), 172(11), 6427-6434

Plasmids were prepared by inserting genomic DNA fragments from Streptomyces cacaoi within the mel gene of plasmid pIJ702. The inserted DNA fragments contain the beta-lactamase-encoding bla gene and ... [more ▼]

Plasmids were prepared by inserting genomic DNA fragments from Streptomyces cacaoi within the mel gene of plasmid pIJ702. The inserted DNA fragments contain the beta-lactamase-encoding bla gene and upstream nucleotide sequences of various lengths. The transcription start point of bla was identified by nuclease S1 mapping. Upstream nucleotide sequences of sufficient lengths had an enhancing effect on beta-lactamase production by the Streptomyces host. The dot blot hybridization assay revealed that this effect was exerted at the transcriptional level. Experimental evidence strongly suggests that the underlying mechanism involves, at least in part, one or several trans-acting elements. In one of the constructs, in which the upstream nucleotide sequence was reduced to 0.3 kb, the bla promoter was present but the bla gene was expressed by readthrough from a promoter, possibly the mel promoter, of the pIJ702 vector. [less ▲]

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See detailThe chemical composition of the extreme halo stars. III - Equivalent widths of 20 dwarfs
Zhao, G.; Magain, Pierre ULg

in Astronomy and Astrophysics. Supplement Series (1990), 86

In the first two papers of this series the chemical composition of 20 extreme halo stars was discussed. The abundances of a number of elements were determined using model atmosphere analysis of equivalent ... [more ▼]

In the first two papers of this series the chemical composition of 20 extreme halo stars was discussed. The abundances of a number of elements were determined using model atmosphere analysis of equivalent widths. In this paper a tabulation of the equivalent width data is presented. A comparison of the measurements with the equivalent widths from different sources is used to assess the quality of the data. [less ▲]

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See detailCore velocity dispersion and mass-to-light ratio of the old Magellanic globular cluster NGC 1835
Dubath, P.; Meylan, G.; Mayor, M. et al

in Astronomy and Astrophysics (1990), 239

Abstract image available at: http://adsabs.harvard.edu/abs/1990A&A...239..142D

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See detailThe chemical composition of the extreme halo stars. II - Green spectra of 20 dwarfs
Zhao, G.; Magain, Pierre ULg

in Astronomy and Astrophysics (1990), 238

The abundances of nine elements in the atmospheres of 20 extreme metal-poor stars are derived from green spectra obtained with the ESO Cassegrain Echelle Spectrograph (CASPEC). Sodium is found to be ... [more ▼]

The abundances of nine elements in the atmospheres of 20 extreme metal-poor stars are derived from green spectra obtained with the ESO Cassegrain Echelle Spectrograph (CASPEC). Sodium is found to be overabundant with respect to aluminum by as much as one dex. There is some scatter in Ca/Fe which cannot be accounted for by random errors in equivalent widths or atmospheric parameters. Scandium is overabundant relative to iron. Some barium lines may be affected by strong departures from local thermodynamic equilibrium. The nitrogen-rich metal-poor star HD 74000, which was found in previous work to be also Al-rich, also presents higher than usual abundances of Na and of s-process elements. It can thus be considered as a mild barium dwarf of Population II. [less ▲]

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See detailLe tamoxifene comme premier traitement du cancer du sein chez la femme âgée: un recul de 10 ans
Colin, Claude ULg; Lifrange, Eric ULg; Genicot, F. et al

in Revue Médicale de Liège (1990), 45(11), 533-8

Cinquante-six patientes, âgées de plus de 70 ans, ont été traitées par tamoxifène pour cancer mammaire T1 à T4. Un délai de 3 à 6 mois est nécessaire pour obtenir une régression de l'opacité tumorale dans ... [more ▼]

Cinquante-six patientes, âgées de plus de 70 ans, ont été traitées par tamoxifène pour cancer mammaire T1 à T4. Un délai de 3 à 6 mois est nécessaire pour obtenir une régression de l'opacité tumorale dans 46,4% des cas, une stabilisation dans 30,4% et une augmentation dans 23,2%. Le type de réponse semble indépendant du stade initial de la tumeur. La survie globale à 10 ans n'est pas différente de cette des patientes de même âge qui avaient préféré recourir au traitement loco-régional classique. Par contre, en cas de régression tumorale, la durée de la survie est nettement plus longue et est comparable à celle d'une population témoin de même âge. Les récidives locales sont fréquentes. Elle sont de moins bon pronostic si elles surviennent au cours des trois premières années du traitement. La véritable cause du décès est souvent difficile à préciser chez ces patientes. Une relation directe avec le cancer mammaire n'est observée que dans la moitié des cas. [less ▲]

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See detailDétermination du degré de réticulation du collagène par sa solubilité thermique et par analyse calorimétrique différentielle (ACD).
Bastiaens, Annette; Sindic, Marianne ULg; Deroanne, Claude et al

in Viandes et Produits Carnés (1990), 11

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See detailInfluence of breed of fetus on periparturient endocrine responses and subsequent milk production of Ayrshire dams
Guilbault, L. A.; Roy, G. L.; Beckers, Jean-François ULg et al

in Journal of Dairy Science (1990), 73(10), 2766-2773

Purebred Ayrshire females were assigned to two groups based on the breed of fetus carried during gestation. In group 1, Limousin embryos were transferred nonsurgically into Ayrshire recipients (10 heifers ... [more ▼]

Purebred Ayrshire females were assigned to two groups based on the breed of fetus carried during gestation. In group 1, Limousin embryos were transferred nonsurgically into Ayrshire recipients (10 heifers and 1 cow), and in group 2, 11 Ayrshire heifers and 1 cow were inseminated artificially to Ayrshire bulls. Blood samples were collected daily from d 265 of gestation until d 15 postpartum from 5 heifers of each group. Milk yield was recorded on alternate weeks during the first 20 wk postpartum. Calf birth weight was higher (44.2 vs. 35.4 kg) and gestation was longer (297.4 vs. 280.2 d) in Ayrshire dams bearing Limousin fetuses than in those bearing Ayrshire fetuses. Daily milk production for the first 20 wk was lower (18.1 vs. 20.8 kg) in Ayrshire dams bearing Limousin fetuses than in those bearing Ayrshire fetuses. Prepartum decrease in progesterone concentrations and increase in estrone concentrations were faster in Ayrshire heifers bearing Limousin fetuses than in those bearing Ayrshire fetuses. Profiles of peripartum concentrations of bovine placental lactogen differed between Ayrshire dams carrying different families of Limousin fetuses but were similar in those carrying families of Ayrshire fetuses. The concentrations of 15-keto-13,14-dihydroprostaglandin F2 were lower during the postpartum period in heifers that gave birth to Limousin calves than in those that had Ayrshire calves. In conclusion, the breed of fetus influences physiological and endocrine responses of the dam, which might have some effect on milk production of the dam. [less ▲]

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See detailAndrogen and Estrogen Action in the Preoptic Area and Activation of Copulatory Behavior in Quail
Balthazart, Jacques ULg; Surlemont, C.

in Physiology & Behavior (1990), 48(5), 599-609

The sites of androgen and estrogen action on sexual behavior were studied in the preoptic area of castrated male Japanese quail by stereotaxic implantation of hormones, antihormones and metabolism ... [more ▼]

The sites of androgen and estrogen action on sexual behavior were studied in the preoptic area of castrated male Japanese quail by stereotaxic implantation of hormones, antihormones and metabolism inhibitors. The first experiment demonstrated that bilateral implantation of the aromatase inhibitor, androstatrienedione (ATD), in the sexually dimorphic nucleus (POM) of the preoptic area can completely suppress the behavioral activation produced by a systemic treatment with testosterone. The effects of ATD were only observed if the implants were located in the POM. In the second experiment, implants in the POM of the synthetic estrogen, diethylstilbestrol, restored copulatory behavior in castrated males while implants of the synthetic nonaromatizable androgen, methyltrienolone, were almost ineffective. During the third experiment, the activating effects of a systemic treatment with testosterone were blocked by stereotaxic implants in the POM of the antiestrogen, tamoxifen, or the antiandrogen, flutamide. The effects of tamoxifen were more pronounced than those of flutamide. In addition, tamoxifen was active in all parts of the POM while a behavioral inhibition was observed only for flutamide implants which were located in the caudal part of the nucleus. Taken together, these results demonstrate that the sexually dimorphic POM is the area where the behaviorally active estrogenic metabolites of T have to be produced. The estradiol derived from T aromatization presumably acts within the POM to activate copulation as demonstrated by the effectiveness of DES implanted in this region. Androgens also have a direct action on sexual behavior as suggested by the partial inhibition observed in flutamide-treated birds. It is, however, suggested that androgens and estrogens do not act in the same brain area to activate behavior. [less ▲]

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See detailRole of the Conserved Amino Acids of the 'Sdn' Loop (Ser130, Asp131 and Asn132) in a Class a Beta-Lactamase Studied by Site-Directed Mutagenesis
Jacob, Françoise; Joris, Bernard ULg; Lepage, Sophie et al

in Biochemical Journal (1990), 271(2), 399-406

Ser130, Asp131 and Asn132 ('SDN') are highly conserved residues in class A beta-lactamases forming one wall of the active-site cavity. All three residues of the SDN loop in Streptomyces albus G beta ... [more ▼]

Ser130, Asp131 and Asn132 ('SDN') are highly conserved residues in class A beta-lactamases forming one wall of the active-site cavity. All three residues of the SDN loop in Streptomyces albus G beta-lactamase were modified by site-directed mutagenesis. The mutant proteins were expressed in Streptomyces lividans, purified from culture supernatants and their kinetic parameters were determined for several substrates. Ser130 was substituted by Asn, Ala and Gly. The first modification yielded an almost totally inactive protein, whereas the smaller-side-chain mutants (A and G) retained some activity, but were less stable than the wild-type enzyme. Ser130 might thus be involved in maintaining the structure of the active-site cavity. Mutations of Asp131 into Glu and Gly proved to be highly detrimental to enzyme stability, reflecting significant structural perturbations. Mutation of Asn132 into Ala resulted in a dramatically decreased enzymic activity (more than 100-fold) especially toward cephalosporin substrates, kcat. being the most affected parameter, which would indicate a role of Asn132 in transition-state stabilization rather than in ground-state binding. Comparison of the N132A and the previously described N132S mutant enzymes underline the importance of an H-bond-forming residue at position 132 for the catalytic process. [less ▲]

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See detailHeat transport in dielectric crystals at low temperature: A variational formulation based on extended irreversible thermodynamics
Lebon, Georgy ULg; Dauby, Pierre ULg

in Physical Review (1990), 42

We propose a variational principle applicable to the heat-transport equations derived some years ago by Guyer and Krumhansl [Phys. Rev. 133, 1411 (1964); 148, 766 (1966); 148, 778 (1966)] to describe heat ... [more ▼]

We propose a variational principle applicable to the heat-transport equations derived some years ago by Guyer and Krumhansl [Phys. Rev. 133, 1411 (1964); 148, 766 (1966); 148, 778 (1966)] to describe heat-wave propagation in dielectric crystals at low temperature. The variational principle appears as a generalization of Prigogine's minimum-entropy production criterion. The analysis is based on extended irreversible thermodynamics, which is used to derive the Guyer-Krumhansl equations from macroscopic arguments. [less ▲]

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See detailTropomyosin from the Striated Muscles of Carp (Cyprinus Carpio) and of Icefish (Channichthys Rhinoceratus)
Feller, Georges ULg; D'Haese, J.; Gerday, Charles ULg

in Archives Internationales de Physiologie et de Biochimie (1990), 98(5), 297-305

Tropomyosin of fast-twitch, slow-twitch and cardiac muscles of carp and icefish has been isolated by hydroxyapatite chromatography. The subunit distribution has been investigated by polyacrylamide gel ... [more ▼]

Tropomyosin of fast-twitch, slow-twitch and cardiac muscles of carp and icefish has been isolated by hydroxyapatite chromatography. The subunit distribution has been investigated by polyacrylamide gel electrophoresis and by peptide mapping. The purified skeletal muscle tropomyosins all belong to the alpha family and differ from higher vertebrate tropomyosin by the lack of beta subunits. Specific alpha isotypes are however encountered in fast-twitch fibres (alpha w subunit) and slow-twitch or intermediate (pink) fibres (alpha and alpha w subunits). The amino acid compositions and the paracrystals formed by the carp alpha w alpha w and alpha alpha w tropomyosins do not differ markedly from that of rabbit alpha alpha chains. They differ however by their capability to inhibit the ATPase activity of rabbit skeletal muscle acto-HMM system. A beta-like subunit is found in carp cardiac tropomyosin, in the proportion of 25% of the native protein, but not in icefish heart. [less ▲]

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See detailFormation of P Cygni line profiles in relativistically expanding atmospheres
Hutsemekers, Damien ULg; Surdej, Jean ULg

in Astrophysical Journal (1990), 361

The probabilistic approach of Surdej (1979) is followed to generalize the Sobolev (1958) formalism to the case of special relativity, in order to interpret accurately the P Cygni line profiles observed in ... [more ▼]

The probabilistic approach of Surdej (1979) is followed to generalize the Sobolev (1958) formalism to the case of special relativity, in order to interpret accurately the P Cygni line profiles observed in the spectrum of broad absorption-line quasars and supernovae. The expressions of the source function and of the line profile are derived, and it is shown that the relativistic P Cygni line profiles are significantly different from those computed in the framework of the classical theory. Thus, for increasing values of the terminal wind velocity, the red emission wing becomes definitely narrower than the blue one, while the line center emission increases. This is no longer symmetrical in accordance with the relativistic expression of the Doppler effect. [less ▲]

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See detailVariational Metric and Exponential Penalization
Mouallif, Khalil; Tossings, Patricia ULg

in Journal of Optimization Theory & Applications (1990), 67(1), 185-192

Attouch and Wets have introduced recently a variational metric between closed proper convex functions. The aim of this note is to give an estimation of this metric in the case of the exponential penalties ... [more ▼]

Attouch and Wets have introduced recently a variational metric between closed proper convex functions. The aim of this note is to give an estimation of this metric in the case of the exponential penalties. We can therefore recover some convergence results for the exponential penalty method. [less ▲]

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See detailEngineering a Novel Beta-Lactamase by a Single Point Mutation
Jacob, F.; Joris, Bernard ULg; Dideberg, O. et al

in Protein Engineering (1990), 4(1), 79-86

beta-Lactamases are widespread and efficient bacterial enzymes which play a major role in bacterial resistance to penicillins and cephalosporins. In order to elucidate the role of the residues lying in a ... [more ▼]

beta-Lactamases are widespread and efficient bacterial enzymes which play a major role in bacterial resistance to penicillins and cephalosporins. In order to elucidate the role of the residues lying in a conserved loop of the enzymatic cavity of the active-site serine Streptomyces albus G beta-lactamase, modified proteins were produced by oligo-directed mutagenesis. Mutation of Asn116, which lies on one side of the active site cavity pointing to the substrate-binding site, into a serine residue resulted in spectacular modifications of the specificity profile of the enzyme. That replacement yielded an enzyme with a nearly unchanged activity towards good penicillin substrates. In sharp contrast its efficiency in hydrolysing cephalosporins was drastically reduced, the best substrates suffering the largest decrease in the second-order rate constant for serine acylation. In fact that single mutation generated a truly new enzyme behaving exclusively as a penicillinase, a situation which is never encountered to the same degree in any of the numerous naturally occurring variants of class A beta-lactamases. [less ▲]

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See detailLes Cajuns de Louisiane
Sacré, Robert ULg

in Prologue (1990), (232), 43-45

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See detailRotational analysis of the a3Πr-X1Σ+ transition of AlI
Mahieu, Emmanuel ULg; DUBOIS, I.; BREDOHL, H.

in Journal of Molecular Spectroscopy (1990), 143(2), 359-365

The a3Πr-X1Σ+ transition of Al I has been analyzed for the first time. Accurate rotational and vibrational constants are given for the a3Πr electronic state.

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See detailLes étudiants en Droit: études et projets d'insertion professionnelle
Robert, Jocelyne ULg

in Annales de Droit de Liège (1990), 6-7

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See detailDetection of Chloroplast DNA by Using Fluorescent Monoclonal Anti-Bromodeoxyuridine Antibody and Analysis of Its Fate During Zygote Formation in Chlamydomonas Reinhardtii
Munaut, Carine ULg; Dombrowicz, D.; Matagne, René-Fernand ULg

in Current Genetics (1990), 18(3), 259-63

A monoclonal anti-bromodeoxyuridine antibody conjugated to fluorescein was used to detect the chloroplast nucleoids after specific incorporation of bromodeoxyuridine (BUdR) into the chloroplast DNA of ... [more ▼]

A monoclonal anti-bromodeoxyuridine antibody conjugated to fluorescein was used to detect the chloroplast nucleoids after specific incorporation of bromodeoxyuridine (BUdR) into the chloroplast DNA of Chlamydomonas reinhardtii. The incorporation of BUdR was enhanced by simultaneous treatment with fluorodeoxyuridine (FUdR). The method was applied to analyze the fate of chloroplast DNA in zygotes resulting from mating between BUdR-treated gametes (mt+ or mt-) and untreated gametes of opposite mating-type. In crosses between wild-type strains, the nucleoids of mt+ origin remained in the large majority of zygotes whereas those of mt- origin most often disappeared within the first hours following copulation. In crosses of the type mat-3 mt+ x wild-type mt- (the mat-3 mutation permits a high transmission of chloroplast genes from the mt- parent), the nucleoids of mt- origin were generally not eliminated which indicates that the mat-3 mutation prevents the selective destruction of paternal chloroplast DNA in the zygote. [less ▲]

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See detailCloning, Nucleotide Sequence and Amplified Expression of the Gene Encoding the Extracellular Metallo (Zn) Dd-Peptidase of Streptomyces Albus G
Duez, Colette ULg; Lakaye, Bernard ULg; Houba, Simone et al

in FEMS Microbiology Letters (1990), 71(1-2), 215-219

The gene encoding the extracellular metallo (Zn) DD-peptidase of Streptomyces albus G has been cloned in Escherichia coli DH5 alpha MCR via pBR322 or 325, and then transferred into Streptomyces lividans ... [more ▼]

The gene encoding the extracellular metallo (Zn) DD-peptidase of Streptomyces albus G has been cloned in Escherichia coli DH5 alpha MCR via pBR322 or 325, and then transferred into Streptomyces lividans TK24 via pIJ486, with substantial amplification of the expressed DD-peptidase. The gene has the information for the synthesis of a 255 amino acid precursor, the amino terminal region of which has the characteristic features of a signal peptide. The primary structure as deduced from nucleotide sequencing confirms that previously determined by chemical methods except for the occurrence of an Asp instead of Asn at position 1 and an additional Ala immediately downstream of Pro67. [less ▲]

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See detailThe warm Cretaceous climate - Role of the long-term carbon cycle
Gérard, Jean-Claude ULg; Dols, Vincent

in Geophysical Research Letters (1990), 17

An annual energy-balance model is coupled to a steady state formulation of the long-term CO2 cycle to investigate the possible sources of global warming of the Cretaceous period. It is found that ... [more ▼]

An annual energy-balance model is coupled to a steady state formulation of the long-term CO2 cycle to investigate the possible sources of global warming of the Cretaceous period. It is found that paleogeography solely is an insufficient factor but that the different latitudinal distribution of continental masses 100 My ago influenced the CO2 cycle and favored a larger content of the atmospheric CO2 level. A larger rate of tectonic activity and the possible influence of the vegetation in a CO2 richer atmosphere provide further sources of atmospheric carbon dioxide increase. The combination of these factors, together with a more vigorous poleward heat transport, provides CO2 levels 5 to 15 times larger than today and a global surface warming within the 6-1 C estimated from paleoindicators. [less ▲]

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See detailAcromegaly, multinodular goiter, and silent polyostotic fibrous dysplasia : a variant of the Mc Cune Albright syndrome.
Abs, R.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Journal of Endocrinological Investigation (1990), 13(8), 671-675

A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident ... [more ▼]

A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident. The presence of a pituitary mass and the secretory dynamics of growth hormone and prolactin were suggestive of a mammosomatotroph cell adenoma. A toxic multinodular goiter was also associated, but unique was the spontaneous normalization of the thyroid function. Unusual was the silent evolution of the polyostotic fibrous dysplasia, which was only fortuitously discovered during magnetic resonance imaging of the pituitary region. Treatment of the acromegaly with the long-acting somatostatin analogue octreotide resulted in an important inhibition of the GH secretion and in a reduction of the volume of the pituitary adenoma. [less ▲]

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See detailContingent Negative Variation in Migraine
Bocker, K. B.; Timsit-Berthier, M.; Schoenen, Jean ULg et al

in Headache (1990), 30(9), 604-9

The Contingent Negative Variation (CNV) is an event-related slow potential. It was recorded in healthy volunteers (n = 8) and in patients suffering from migraine without (n = 12) or with (n = 5) aura ... [more ▼]

The Contingent Negative Variation (CNV) is an event-related slow potential. It was recorded in healthy volunteers (n = 8) and in patients suffering from migraine without (n = 12) or with (n = 5) aura, during one (CNV1) and three second (CNV3) foreperiods in a forewarned reaction time task. CNV1 was recorded at the vertex while CNV3 was recorded at multiple electrode sites to assess topographical differences. Seven out of twelve migraine patients without aura had increased CNV1 amplitudes. CNV3 amplitudes were increased as well, but only at electrode positions C3 and C4 and not at Fz. CNV3, which allows for analysis of both an early and a late CNV component, could improve the discrimination of migraine without aura beyond that of CNV1. In migraine with aura all CNV parameters were at control levels, confirming previous results. The data obtained are discussed in terms of arousal, activation and stress and the "biobehavioral model of migraine" (Welch, 1986). [less ▲]

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See detailThe rotational analysis of the B2Σ+-X2Πr transition of 74Ge35Cl
Mahieu, Emmanuel ULg; DUBOIS, Iwan; BREDOHL, Harald et al

in Journal of Molecular Spectroscopy (1990), 143(1), 91-99

A complete rotational analysis of six bands of GeCl is given. It concerns the B2Σ+-X2Πr transition of the most abundant isotopic species, 74Ge35Cl.

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See detailQuantitative nephelometric assay for determining myoglobin evaluated
Delanghe, J. R.; Chapelle, Jean-Paul ULg; Vanderschueren, S. C.

in Clinical Chemistry (1990), 36(9), 1675-8

A recently introduced automated nephelometric immunoassay involving shell/core particles for determination of myoglobin (Behringwerke) was evaluated with the BNA Nephelometer. Method precision was good ... [more ▼]

A recently introduced automated nephelometric immunoassay involving shell/core particles for determination of myoglobin (Behringwerke) was evaluated with the BNA Nephelometer. Method precision was good: the intra-assay CV varied between 1.5% and 6.1%; with daily calibration, the interassay CV ranged between 1.5% and 7.5%. For usual sample dilutions, the assay response varied linearly with myoglobin concentrations up to 23.1 nmol/L. After automatic dilution by the instrument, concentrations up to 2310 nmol/L could be measured without high-dose "hook" effect. Further manual dilution allowed measurement of myoglobin concentrations up to 26,000 nmol/L. Calibration was stable for at least seven days. We detected no significant interferences from hemoglobin, haptoglobin, bilirubin, iodine-containing contrast media, and rheumatoid factors. Treating lipemic samples with Lipoclean (Behringwerke) decreased test results. Simultaneously drawn serum and plasma samples from the same subject showed no consistent differences in myoglobin concentrations. The mean reference myoglobin concentration was 1.380 (SD 0.82) nmol/L for men and 0.878 (SD 0.45) nmol/L for women. In patients with renal insufficiency, serum creatinine values were moderately related to serum myoglobin values (r = 0.465). Although a commercial radioimmunoassay (Byk-Sangtec) and the nephelometric assay intercorrelated well (r = 0.929), values obtained by nephelometry were significantly lower (P less than 0.05). By both assays, results for heart and skeletal muscle tissue extracts showed no correlation, a finding that suggests the existence of multiple forms of myoglobin in human tissues. We conclude that immunonephelometry is a rapid, practical, and reliable method for measuring myoglobin in serum. [less ▲]

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See detailTriplet Yield of Merocyanine 540 in Water Is Wavelength Dependent
Seret, Alain ULg; Hoebeke, Maryse ULg; Van de Vorst, Albert

in Photochemistry and Photobiology (1990), 52(3), 601-604

Monomers and aggregates of Merocyanine 540 (MC540) in water are able to photoisomerize. The shape of the photoisomer absorption spectrum is very similar to that of the ground state. Triplet state of MC540 ... [more ▼]

Monomers and aggregates of Merocyanine 540 (MC540) in water are able to photoisomerize. The shape of the photoisomer absorption spectrum is very similar to that of the ground state. Triplet state of MC540 in water has been produced by energy transfer from triplet anthracene and displays a broad absorption spectrum between 600 and 700 nm. The triplet state may also be produced by direct excitation of MC540 with UV light. However, when the dye is excited by visible light, no triplet state absorbance in the red could be detected so that the triplet yield of MC540 in water seems to be excitation wavelength dependent. [less ▲]

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See detailMitochondrial Genome Transmission in Chlamydomonas Diploids Obtained by Sexual Crosses and Artificial Fusions: Role of the Mating Type and of a 1 Kb Intron
Remacle, Claire ULg; Bovie, C.; Michel-Wolwertz, M. R. et al

in Molecular & General Genetics [=MGG] (1990), 223(2), 180-4

The linear mitochondrial DNAs of the two infertile algal species Chlamydomonas smithii and C. reinhardtii are co-linear with the exception of a 1 kb intron (alpha intron) located in the cytochrome b gene ... [more ▼]

The linear mitochondrial DNAs of the two infertile algal species Chlamydomonas smithii and C. reinhardtii are co-linear with the exception of a 1 kb intron (alpha intron) located in the cytochrome b gene of C. smithii. C. smithii also possesses an additional HpaI restriction site (H marker) located in the COXI gene, about 5 kb from the intron. In reciprocal crosses, C. smithii (H+ alpha +) x C. reinhardtii (H- alpha -), the alpha intron is transmitted to all diploid progeny, whereas the H marker is frequently transmitted either biparentally or paternally depending on whether the C. smithii parent is maternal (mt+) or paternal (mt-). In diploids resulting from artificial fusion between vegetative cells, the absolute transmission of alpha is accompanied by the frequent transmission of the H+ marker, irrespective of the mating type of the parental strains. Finally, in reciprocal crosses between C. smithii (H+ alpha +) and recombinant H- alpha + clones, the transmission of the H marker is predominantly paternal or biparental. These results allow us to conclude that (1) the alpha intron behaves as a group I intron whose unidirectional conversion influences the transmission of the H marker; and (2) the mt- paternal mitochondrial genome is transmitted more often than the mt+. The mating type has no effect in diploids obtained by artificial fusion. [less ▲]

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See detailUltrastructural Localization of Chitin in the Cystic Wall of Euplotes muscicola Kahl (Ciliata, Hypotrichia)
Greco, Ninfa ULg; Bussers, Jean-Claude ULg; Van Daele, Yves et al

in European Journal of Protistology (1990), 26

The ultrastructural localization of chitin in the cyst walls of Euplotes muscicola was determined by labelling with WGA-gold complex.

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See detailAnionic polymerization of acrylic monomers. V. Synthesis, characterization and modification of polystyrene-poly(tert-butyl acrylate) di- and triblock copolymers
Hautekeer, Jean-Paul; Varshney, Sunil K; Fayt, Roger et al

in Macromolecules (1990), 23(17), 3893-3898

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See detailTermination mechanism in the anionic copolymerization of methyl methacrylate and tert-butyl acrylate
Jacobs, Christian; Varshney, Sunil K; Hautekeer, Jean-Paul et al

in Macromolecules (1990), 23(17), 4024-4025

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See detailTranscriptional Analysis of the dd-Peptidase/Penicillin-Binding Protein-Encoding dac Gene of Streptomyces R61: Use of the Promoter and Signal Sequences in a Secretion Vector
Piron-Fraipont, Claudine; Lenzini, Mauro V; Dusart, Jean et al

in Molecular & General Genetics [=MGG] (1990), (223), 114-120

The promoter region of the gene encoding the extracellular DD-peptidase/penicillin-binding protein of Streptomyces R61 has been identified by in vivo promoter probing and S1 mapping. A secretion vector ... [more ▼]

The promoter region of the gene encoding the extracellular DD-peptidase/penicillin-binding protein of Streptomyces R61 has been identified by in vivo promoter probing and S1 mapping. A secretion vector, pDML116, was constructed by inserting into the multicopy Streptomyces plasmid pIJ702, a 247 bp DNA sequence that contained the transcriptional, translational and secretory signals and the 12 amino acid N-terminal region-encoding sequence of the mature Streptomyces DD-peptidase/penicillin-binding protein. Insertion, downstream of this 247 bp segment, of the Streptomyces R61 DD-peptidase-encoding gene or the Escherichia coli R-TEM beta-lactamase-encoding gene yielded plasmids pDML120 and pDML128, respectively, which allowed expression and secretion of the relevant enzymes by Streptomyces lividans. The maximal secretion levels obtained were 42 mg protein/ml for the autologous Streptomyces DD-peptidase and 0.9 mg protein/ml for the heterologous E. coli beta-lactamase. [less ▲]

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See detailPotassium-Induced Release of an Endogenous Toxic Activity for Outer Hair Cells and Auditory Neurons in the Cochlea: A New Pathophysiological Mechanism in Meniere's Disease?
Lefebvre, Philippe ULg; Weber, T.; Rigo, Jean-Michel et al

in Hearing Research (1990), 47(1-2), 83-93

In Meniere's disease, the increase of extracellular potassium concentration in the perilymph is thought to play a key role in determining the progressive loss of cochlear hair cells. In this paper, we ... [more ▼]

In Meniere's disease, the increase of extracellular potassium concentration in the perilymph is thought to play a key role in determining the progressive loss of cochlear hair cells. In this paper, we describe a serum-free culture preparation of hair cells from 5 day-old rat and report the release by the cochlea, in response to an increase of extracellular potassium concentration, of a cytotoxic activity active on hair cells and auditory neurons. The toxic activity is associated with low molecular weight (less than 10,000 Dalton) molecule(s) as revealed by ultrafiltration. Morphological studies performed on the organ of Corti incubated during 24 h in the presence of the cochlea-derived toxic activity (CTA), show that this factor is toxic for hair cells and not for supporting or surrounding cells. The release of CTA occurs both in the spiral ganglion and in the organ of Corti. We suggest that this cochlea-derived toxic activity may play an important role in the pathophysiology of the hearing loss that occurs during the progression of Meniere's disease. [less ▲]

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See detailAnalysis of the light variations of the Wolf-Rayet star WR16
Gosset, Eric ULg; Vreux, Jean-Marie ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics. Supplement Series (1990), 84

This paper presents new data sets of Stromgren differential photometry observations of the Wolf-Rayet star WR16, collected at the ESO (La Silla, Chile). Results of detailed data analyses support previous ... [more ▼]

This paper presents new data sets of Stromgren differential photometry observations of the Wolf-Rayet star WR16, collected at the ESO (La Silla, Chile). Results of detailed data analyses support previous findings concerning the variability of WR16, with dominating power at frequencies below 1.5/d. The variations were found to be positively correlated on time lags up to about two days, a characteristic delay larger than the time of replacement of a typical WR star wind. A simple stochastic model is developed for the low frequency variability of the star, which is able to explain the available observations. [less ▲]

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See detailSolar cycle variation of thermospheric nitric oxide at solstice
Gérard, Jean-Claude ULg; Fesen, C. G.; Rusch, D. W.

in Journal of Geophysical Research (1990), 95

A coupled, two-dimensional, chemical-diffusive model of the thermosphere is used to study the role of solar activity in the global distribution of nitric oxide. The model calculates self-consistently the ... [more ▼]

A coupled, two-dimensional, chemical-diffusive model of the thermosphere is used to study the role of solar activity in the global distribution of nitric oxide. The model calculates self-consistently the zonally averaged temperature, circulation, and composition for solstice under solar maximum and solar minimum conditions. A decrease of the NO density by a factor of three to four in the E region is predicted from solar maximum to solar minimum. It is found that the main features of the overall morphology and the changes induced by the solar cycle are well reproduced in the model, although some details are not satisfactorily predicted. The sensitivity of the NO distribution to eddy transport and to the quenching of metastable N(2D) atoms by atomic oxygen is also described. [less ▲]

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See detailPituitary microadenomas: diagnosis with two-and three-dimensional MR imaging at 1.5 T before and after injection of gadolinium.
Stadnik, T.; Stevenaert, Achille ULg; Beckers, Albert ULg et al

in Radiology (1990), 176(2), 419-428

The usefulness of different magnetic resonance (MR) imaging sequences (coronal and sagittal spin-echo [SE] and three-dimensional fast low-angle shot [3D FLASH]) in the detection of pituitary microadenomas ... [more ▼]

The usefulness of different magnetic resonance (MR) imaging sequences (coronal and sagittal spin-echo [SE] and three-dimensional fast low-angle shot [3D FLASH]) in the detection of pituitary microadenomas before and after gadolinium injection was prospectively evaluated in 28 patients with surgical confirmation. When evaluated separately, the most useful sequences in the detection of these microadenomas were coronal pregadolinium T1-weighted SE, coronal pregadolinium 3D FLASH, coronal postgadolinium T1-weighted SE, and coronal postgadolinium 3D FLASH. The combination of pre- and postgadolinium T1-weighted sequences with pre-and postgadolinium 3D FLASH sequences produced the highest number of true-positive findings (90%) and the lowest number of false-positive findings (5%). When a 1.5-T imaging unit with a high signal-to-noise ratio allowing useful three-dimensional acquisition is used, the authors advocate a coronal T1-weighted SE sequence, followed (if necessary) by a coronal 3D FLASH sequence, both without injection of gadolinium, in the diagnosis of pituitary microadenomas. When no confident diagnosis is reached, the same sequences should be performed after the injection of gadolinium. The sagittal pre- and postgadolinium T1-weighted SE and long-TR SE sequences are useful only in specific cases. [less ▲]

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See detailAbnormal Thymocyte Subpopulations in Split Dose Irradiated C57bl/Ka Mice before the Onset of Lymphomas. Effects of Bone Marrow Grafting
Rongy, A. M.; Humblet, Chantal ULg; Lelievre, P. et al

in Thymus (1990), 16(1), 7-27

Fractionated whole-body X irradiation (4 x 1.75 Gy at weekly intervals) induces a high percentage of thymic lymphomas in C57BL/Ka mice. The present work reports the phenotypic alterations of thymocyte ... [more ▼]

Fractionated whole-body X irradiation (4 x 1.75 Gy at weekly intervals) induces a high percentage of thymic lymphomas in C57BL/Ka mice. The present work reports the phenotypic alterations of thymocyte subpopulations during the preleukemic period: there were a decrease of CD4+ CD8+ cells and an increase of CD4- CD8- and CD4- CD8+ cells. Marrow grafting early after irradiation that prevents lymphoma development restores the thymocyte subpopulations. In many instances, transplantation of 'preleukemic thymocyte inoculate' gives rise to an active and long lasting repopulation of recipient thymuses. However in all cases, donor lymphomas can develop after inoculation of 'preleukemic thymocyte inoculate'. [less ▲]

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See detailElectrostatic Potential Maps at the Quantum Chemistry Level of the Active Sites of the Serine Peptidases, Alpha-Chymotrypsin and Subtilisin
Lamotte-Brasseur, Josette; Dive, Georges ULg; Dehareng, Dominique ULg et al

in Journal of Theoretical Biology (1990), 145(2), 183-98

The electronic properties of the active-sites of the structurally unrelated serine peptidases, alpha-chymotrypsin and subtilisin, have been expressed in the form of three-dimensional electrostatic ... [more ▼]

The electronic properties of the active-sites of the structurally unrelated serine peptidases, alpha-chymotrypsin and subtilisin, have been expressed in the form of three-dimensional electrostatic potential maps derived from integrals calculated at the quantum chemistry level. As a consequence of the asymmetrical distribution of the secondary structures that occur within a 7 A sphere around the serine of the catalytic triad, the active sites are highly polarized entities and exhibit large dipole moments. One part of the active sites generates a nucleophilic suction-pump. Its isocontour at -10 kcal mol-1 defines an impressive, negatively-charged volume which bears a narrow channel in the immediate vicinity of the active-site serine 195 in alpha-chymotrypsin or 221 in subtilisin. In native alpha-chymotrypsin, there is a perfect complementation between this nucleophilic suction-pump and the positively-charged electrophilic hole that is generated by the backbone NH of Ser 195 and Gly 193. In subtilisin, generation of the complementing electrophilic hole requires binding of a carbonyl donor ligand and may be achieved by rotation of the side-chain amide of Asn 155 towards the backbone NH of Ser 221. Small variations in the atomic co-ordinates of alpha-chymotrypsin used for the calculations, the presence of water molecules in its active site and the occurrence of point mutations in the amino acid sequence of subtilisin have little effects on the shape and characteristics of the electrostatic potential. [less ▲]

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See detailA search for quasars in a field around NGC 520
Gosset, Eric ULg; Clowes, R. G.; Surdej, Jean ULg et al

in Monthly Notices of the Royal Astronomical Society (1990), 245

An objective-prism search for quasars was performed in a field around the galaxy NGC 520. The automated quasar detection software has been applied, and a sample of 175 highly rated quasar candidates has ... [more ▼]

An objective-prism search for quasars was performed in a field around the galaxy NGC 520. The automated quasar detection software has been applied, and a sample of 175 highly rated quasar candidates has been selected. The two- and three-dimensional distributions of the candidates have been analyzed. The distribution on the celestial sphere turns out to be nonrandom. The deviations from randomness are both a tendency to exhibit anticorrelation at the scale of a few arcmin and a significant excess of objects at separations of about 20 arcmin. Finally, in order to test the claims by Arp and Duhalde (1985) that an excess of quasars exists near NGC 520 and that there is a preferential NE-SW alignment of bright quasars across this amorphous galaxy, various statistical analyses of the distribution of the high-grade quasar candidates with respect to NGC 520 were performed. No sign of any possible relation is present in the data. [less ▲]

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See detailThe nth order moment W(n)D of a resonance doublet P Cygni line profile
Surdej, Jean ULg; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1990), 233

The theory of the nth order moment W(n)D of a P Cygni line profile due to a resonance doublet line transition is developed here in the framework of the Sobolev approximation. It is shown that, in the ... [more ▼]

The theory of the nth order moment W(n)D of a P Cygni line profile due to a resonance doublet line transition is developed here in the framework of the Sobolev approximation. It is shown that, in the optically thick approximation, the asymptotic value W(n)D,t is entirely dependent on both the doublet separation and the type of the velocity field characterizing the expanding atmosphere. The most useful P Cygni profiles seem to be those which are unsaturated. [less ▲]

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See detailCardiac Transplantation Beyond 55 Years of Age
Defraigne, Jean-Olivier ULg; Demoulin, J. C.; Beaujean, M. A. et al

in Transplant International (1990), 3(2), 59-61

Between January 1985 and December 1988, 20 patients over the age of 55 years (extremes 56-63 years; 15 men and 5 women) underwent cardiac transplantation. The cause of cardiopathy was ischemic in 70% of ... [more ▼]

Between January 1985 and December 1988, 20 patients over the age of 55 years (extremes 56-63 years; 15 men and 5 women) underwent cardiac transplantation. The cause of cardiopathy was ischemic in 70% of the cases. The immunosuppressive regimen consisted of cyclosporin A, corticoids, and azathioprine. Rejection episodes were monitored by endomyocardial biopsies and treated by pulses of corticoids or monoclonal antibodies (OKT3). The operative mortality was 10% (n = 2). The 1-year survival rate was 70%. The 1-year incidence of infection and/or rejection episodes was 1 and 1.53 episodes/patient, respectively. One patient was successfully retransplanted after 9 months because of intractable rejection. Age beyond 55 years is no longer a contraindication to cardiac transplantation. This change in recipient selection policy should lead to parallel changes in donor selection criteria. [less ▲]

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See detailPrimary Pulmonary Hemangiopericytoma: Early Local Recurrence after Perioperative Rupture of the Giant Tumor Mass (Two Cases)
VAN DAMME, Hendrik ULg; DEKOSTER, Guy ULg; CREEMERS, Etienne ULg et al

in Surgery (1990), 108(1), 105-9

We report two recent observations of giant hemangiopericytoma of the lung, one in a 4-year-old child and another in a 65-year-old man. There were no specific clinical signs, but the radiologic appearance ... [more ▼]

We report two recent observations of giant hemangiopericytoma of the lung, one in a 4-year-old child and another in a 65-year-old man. There were no specific clinical signs, but the radiologic appearance was rather characteristic in both cases, as were the histologic findings. Pneumonectomy was carried out, complicated in each case by rupture of the fragile, incomplete pseudocapsule and diffuse dissemination of necrotic tumor tissue in the operative field and opposite bronchial tree. Outcome was fatal in both cases within a few months, with extensive, rapidly growing metastases in the subcutaneous scar tissue of the thoracotomy and in the other lung and in one case with diffuse diaphragmatic and intraabdominal metastases. These two observations will offer some guidelines for better understanding of this rare localization of hemangiopericytoma, its natural history, and its optimal treatment, with special reference to the malignant potential and local recurrence rate. [less ▲]

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See detailMicrospherophakia-Metaphyseal Dysplasia: A 'New' Dominantly Inherited Bone Dysplasia with Severe Eye Involvement
Verloes, Alain ULg; Van Maldergem, Lionel ULg; de Marneffe, Pierre et al

in Journal of Medical Genetics (1990), 27(7), 467-71

We report a father and son affected by a hitherto unpublished bone dysplasia with moderately severe dwarfism. On initial radiographs, thickening of the diaphyses of the long bones was striking. The small ... [more ▼]

We report a father and son affected by a hitherto unpublished bone dysplasia with moderately severe dwarfism. On initial radiographs, thickening of the diaphyses of the long bones was striking. The small bones of the extremities were almost unaffected. With age, the metaphyseal deformation became more prominent. The epiphyses became irregular and their growth was delayed (particularly the femoral heads). The femoral neck showed an unusual 'lip' on the inner edge. Later, the stubby appearance of the long bones faded and, in adulthood, only enlarged metaphyses and deformed femoral necks persisted. The vertebrae showed moderate deformation with irregular flattening, and narrowing of the spinal canal with a shortened interpedicular distance. The eye defects consisted of high grade myopia, microspherophakia, lens coloboma, lens luxation, and retinal detachment. The name 'microspherophakia-metaphyseal dysplasia' is suggested for this probably autosomal dominant bone dysplasia. [less ▲]

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See detailEffects of FeSO4 on B16 melanoma cells differentiation and proliferation
Gillet, Marie-Claire ULg; Siwek, Brigitte; Pozzi, G. et al

in Anticancer Research (1990), 10(4), 1029-1033

The paper shows that FeS04 can increase or reduce B16 cell proliferation and melanogenesis. Vitamin C toxicity for B16 cells was reduced in the presence of FeSO4.

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See detailEffects of Castration and Testosterone Treatment on the Activity of Testosterone-Metabolizing Enzymes in the Brain of Male and Female Zebra Finches
Vockel, A.; Prove, E.; Balthazart, Jacques ULg

in Journal of Neurobiology (1990), 21(5), 808-25

Recently, we described the distribution of testosterone-metabolizing enzymes (i.e., aromatase, 5 alpha- and 5 beta-reductases) in the zebra finch (Taeniopygia guttata) brain using a sensitive radioenzyme ... [more ▼]

Recently, we described the distribution of testosterone-metabolizing enzymes (i.e., aromatase, 5 alpha- and 5 beta-reductases) in the zebra finch (Taeniopygia guttata) brain using a sensitive radioenzyme assay combined to the Palkovits punch method. A number of sex-differences in the activity of these enzymes were observed especially in nuclei of the song-control system. The hormonal controls of these differences have now been analyzed by gonadectomizing birds of both sexes and by giving them a replacement therapy with silastic implants of testosterone (T). Five nuclei of the song system (Area X [X], nucleus magnocellularis of the anterior neostriatum [MAN], nucleus robustus archistriatalis [RA], nucleus intercollicularis [ICo], hyperstriatum ventrale, pars caudalis [HVc]) and three preoptic-hypothalamic areas (preoptic anterior [POA], periventricular magnocellular nucleus [PVM], and posterior medial hypothalamic nucleus [PMH]) were studied as well as other limbic and control non-steroid-sensitive areas. The activity of the 5 alpha-reductase was higher in males than in females for the five song-control nuclei and was not affected by the hormonal treatments. The overall activity of this enzyme was not sexually dimorphic in POA and PVM. It was higher in males than in females in intact birds only, and was reduced by gonadectomy and enhanced by T. The activity of the 5 beta-reductase was higher in females than in males in all nuclei of the song system and in POA, but was not influenced by the changes in T level. Both sex and treatment effects were observed in the control of aromatase. The production of estrogens was dimorphic (females greater than males) in RA and PMH. It was increased by T in POA, PVM, and PMH, and also in RA. These data show that some of the sex differences in T-metabolizing enzymes result from the exposure to different levels of T in adulthood (e.g., 5 alpha-reductase in POA and PVM or aromatase in PVM), whereas others persist even if birds are exposed to the same hormonal conditions. These are presumably the result of organizational effects of steroids. The steroid modulation of the aromatase might be related directly to the activation of sexual, aggressive, and nest-building behaviors, whereas the stable dimorphism in 5 alpha- and 5 beta-reductase observed in the nuclei of the song system might be one of the neurochemical bases of the sex differences in the vocal behavior of the zebra finch. [less ▲]

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See detailLa myosite ossifiante traumatique
Laurent, L.; Wang, François-Charles ULg; Crielaard, Jean-Michel ULg

in Revue Médicale de Liège (1990), 45(7), 321-30

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See detailFirst spectroscopic evidence of microlensing on a BAL quasar? The case of H 1413 + 117
Angonin, M.-C.; Vanderriest, C.; Remy, M. et al

in Astronomy and Astrophysics (1990), 233

New data has been obtained for the quadruply lensed quasar H 1413 + 117 using the bidimensional spectrograph SILFID at the CFH telescope. The spectra recorded for each of the four individual images turn ... [more ▼]

New data has been obtained for the quadruply lensed quasar H 1413 + 117 using the bidimensional spectrograph SILFID at the CFH telescope. The spectra recorded for each of the four individual images turn out to be quite similar, except for the narrow absorption line systems (probably related to the lenses) seen in images A and B and for marked differences in the spectrum of image D. When compared to the three other images, the spectrum of D shows smaller values for the emission lines/continuum ratio and a larger equivalent width for absorption features located in the blueshifted P Cygni profile. The possible explanations of these observations are briefly discussed in terms of micro-lensing and/or intrinsic variability of the source. [less ▲]

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See detailNo-Carrier-Added Regioselective Preparation of 6-[18f]Fluoro-L-Dopa
Bozet, Claire ULg; Guillaume, Marcel; Cantineau, R. et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1990), 31(7), 1247-51

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2 ... [more ▼]

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2-nitrobenzaldehyde (nitroveratraldehyde) and 6-nitropiperonal. Fluorination was conducted in DMSO with fluorine-18 (18F) in the presence of the aminopolyether Kryptofix 222 and potassium carbonate. The condensation of the fluorinated aldehydes with phenyloxazolone and the subsequent hydrolysis with HI/P yield, after purification by HPLC, only the 6-(D, L) isomers. The racemic mixture (50/50) was resolved on an analytical scale chiral column. The method, which requires 100 min (EOB) to complete, produces 6-[18F]fluoro-L-dopa with a decay-corrected radiochemical yield of 10%, an enantiomeric purity greater than 99%, and a specific activity of 1.2 Ci/mumole. [less ▲]

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See detailArguments en faveur de l'existence d'un inhibiteur endogène de la Na-K ATPase rénale, de nature stéroïdienne et a vertu natriuretique
Krzesinski, Jean-Marie ULg; Christiaens, L.; Palem-Vliers, M. et al

in Archives des Maladies du Coeur et des Vaisseaux (1990), 83(8), 1229-1231

In order to explain the opposite effect of 6,7-dihydroxylated isomers of 6, 7 - dihydrocanrenone on the urinary sodium and potassium excretion, we have tested the effect of these substances isolated from ... [more ▼]

In order to explain the opposite effect of 6,7-dihydroxylated isomers of 6, 7 - dihydrocanrenone on the urinary sodium and potassium excretion, we have tested the effect of these substances isolated from human urine on the Na(+)-K+ pump from different tissue preparation: rabbit kidney slices as well as NA-K ATPase purified from the kidney. Our results show an inhibition of pump as well as enzyme activity by the 6 beta 7 alpha isomer while the 2 other isomers are either uneffective or slightly stimulating. The 6 beta 7 alpha dihydroxy-6, 7-dihydrocanrenone could be one of the plasma ouabain-like substance incriminated in the pathogenesis of volume-expanded hypertension. [less ▲]

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See detailCopulatory Behavior Is Controlled by the Sexually Dimorphic Nucleus of the Quail Poa
Balthazart, Jacques ULg; Surlemont, C.

in Brain Research Bulletin (1990), 25(1), 7-14

The medial preoptic nucleus (POM) of the quail preoptic area is sexually dimorphic and testosterone sensitive. Stereotaxic implantation of needles filled with crystalline testosterone demonstrated that ... [more ▼]

The medial preoptic nucleus (POM) of the quail preoptic area is sexually dimorphic and testosterone sensitive. Stereotaxic implantation of needles filled with crystalline testosterone demonstrated that the POM is a critical site of steroid action in the control of copulatory behavior. Only implants located in the POM reliably restored the behavior in castrated birds. Implants around the nucleus weakly activated the behavior; those which were distant by more than 200 microns were totally inactive. Electrolytic lesions confirmed the role of the POM in the control of copulatory behavior. The percentage of the POM which was lesioned was highly correlated to the behavioral deficit while the absolute size of the lesion was not. Electrolytic lesions in or around POM also significantly decreased the volume of the nucleus suggesting that the afferents and efferents of the nucleus are required for its full development. The total volume of the POM was correlated with the sexual behavior of the birds. The morphological changes in POM observed following exposure to testosterone probably represent the signature of the behavioral effects of the steroid. The sexually dimorphic testosterone-sensitive POM is therefore an excellent animal model to study the brain-steroid interactions which mediate the activation of male reproductive behavior. [less ▲]

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See detailMusiques de Louisane
Sacré, Robert ULg

in Soul Bag (1990), (120), 56

Quelques disques valant le détour

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See detailExpression in Escherichia Coli of the Carboxy Terminal Domain of the Blar Sensory-Transducer Protein of Bacillus Licheniformis as a Water-Soluble Mr 26,000 Penicillin-Binding Protein
Joris, Bernard ULg; Ledent, P.; Kobayashi, T. et al

in FEMS Microbiology Letters (1990), 58(1), 107-113

A cloning vector has been constructed which allows production and export by Escherichia coli of the Met346-Arg601 carboxy terminal domain of the 601 amino acid BLAR sensory-transducer involved in beta ... [more ▼]

A cloning vector has been constructed which allows production and export by Escherichia coli of the Met346-Arg601 carboxy terminal domain of the 601 amino acid BLAR sensory-transducer involved in beta-lactamase inducibility in Bacillus licheniformis. The polypeptide, referred to as BLAR-CTD, accumulates in the periplasm of E. coli in the form of a water-soluble, Mr 26,000 penicillin-binding protein. These data and homology searches suggest that BLAR has a membrane topology similar to that of other sensory-transducers involved in chemotaxis. [less ▲]

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See detailEnterohaemolysin and Shiga-like toxin genes in E.coli.
Pohl, P.; Liintermans, P.; Mainil, Jacques ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1990)

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See detailL'état inflammatoire physiologique de la muqueuse digestive
Louis, Edouard ULg; Servais, Benoît; Belaiche, Jacques ULg

in Revue Médicale de Liège (1990), 45(6), 303-10

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See detailHuile de poisson et facteurs de risque d'athérosclérose, un plus par rapport au régime hypolipemiant classique?
Krzesinski, Jean-Marie ULg; Pissart, M. C.; Rorive, Georges ULg

in Revue Médicale de Liège (1990), 45(6), 296-302

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See detailViscoelastic properties of telechelic ionomers. I. Complexed α,ω-diamino polydienes
Charlier, Pascal; Jérôme, Robert ULg; Teyssié, Philippe et al

in Macromolecules (1990), 23(13), 3313-3321

Complexation of the end groups of amino telechelic polydienes strongly affects the viscoelastic behavior. This is shown in the thermal dependence of the isochronous torsion modulus of a liquid ... [more ▼]

Complexation of the end groups of amino telechelic polydienes strongly affects the viscoelastic behavior. This is shown in the thermal dependence of the isochronous torsion modulus of a liquid polybutadiene selectively end-capped by a piperazine unit at both extremities. A rubbery plateau emerges when the telechelic polymer is coordinated to copper(I1) or iron(II1) chlorides. The rubbery plateau extends over a temperature range that depends on the molar ratio of the transition metal to the amine end group. Similar observations have been reported when the dynamic mechanical properties of an a,w-bis(dimethylamino) telechelic polyisoprene have been investigated over the full range of temperature from the glassy plateau to the viscous flow. Upon complexation of the end groups, a rubberlike plateau is observed, which does not exist for the uncomplexed polymer. Furthermore, a secondary relaxation, attributed to the aggregation of the complexed amine end groups, occurs above Tg. The temperature at which the maximum of this relaxation is observed and the distribution of the relaxation times depend on the metal to amine endgroup molar ratio. At a ratio of 1, FeC13 endows the chain network with higher cross-link density than CuC12 does. However, at the same time the temperature width of the rubbery plateau is much shorter for the former than for the latter polymer, indicating a relative thermal instability of the Fe-amine complexes. [less ▲]

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See detailRévolution dans le traitement de l'anémie de l'insuffisant rénal chronique: rôle de l'érythropoïetine humaine recombinée
Panas, N.; Turkowa, M.; Zgheib, A. et al

in Revue Médicale de Liège (1990), 45(6), 280-285

Jusqu'à présent, le traitement de l'anémie de l'insuffisant rénal était peu satisfaisant, vu sa pathogénie multilactorielle, résultant d'un risque de perte accrue de sang, d'un raccourcissement de la ... [more ▼]

Jusqu'à présent, le traitement de l'anémie de l'insuffisant rénal était peu satisfaisant, vu sa pathogénie multilactorielle, résultant d'un risque de perte accrue de sang, d'un raccourcissement de la survie des érythrocytes (hémolyse) el d'une réduction de l'érythropoïèse (par carence en fer, en vitamines B. en acide folique, par intoxication aluminique ou hyperparalhyroïdie). La cause la plus fréquente reste cependant sans conteste la diminution de production de l'érythropoïétine (EPO) comme l'observation, chez l'insuffisant rénal chronique (lAC), d'une anémie le plus souvent normochrome normocytaire peu régénérative, le confirme. Or, l'EPO vient d'être commercialisée (Eprexs, Cilag). Notre propos est de résumer les connaissances sur cette hormone et sa place dans le traitement de l'urémie. [less ▲]

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See detailDual Photon Absorptiometry of Lumbar Spine in West European (Belgian) Postmenopausal Females: Normal Range and Fracture Threshold
Reginster, Jean-Yves ULg; Denis, D.; Deroisy, Rita ULg et al

in Clinical Rheumatology (1990), 9(2), 220-4

Bone mineral content (BMC) and bone mineral density (BMD) of lumbar spine have been measured in 695 healthy postmenopausal and 64 type I osteoporotic Belgian, Caucasian females. Bone loss is strongly ... [more ▼]

Bone mineral content (BMC) and bone mineral density (BMD) of lumbar spine have been measured in 695 healthy postmenopausal and 64 type I osteoporotic Belgian, Caucasian females. Bone loss is strongly correlated to time elapse from menopause (Tm) with a maximum rate of bone loss during the first five years of menopause. BMC (gHA) = 461 + 0.662 ln Tm -0.481 (ln Tm)2 and BMD (gHA/cm2) = 0.91 + 0.00711 ln Tm - 0.00846 (ln Tm)2 (in both cases p less than 0.001 and Tm expressed in months of menopause). After 20 years of menopause, 50 to 60% of normal women have vertebral BMC and BMD values below the 90th percentile of women with vertebral fractures and, thus, might be considered to have asymptomatic osteoporosis. We conclude that prevention of postmenopausal osteoporosis should be initiated as soon as possible after the onset of menopause and that bone density screening should be extended in elderly in order to detect and allow treatment of asymptomatic "densitometric" osteoporosis. [less ▲]

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See detailDe la grammaire, faisons notre affaire !
Dumortier, Jean-Louis ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1990)

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See detailSolubility properties of Eosin Y and Rose Bengal triplet state in sodium dodecyl sulfate micellar solutions
Seret, Alain ULg; Van de Vorst, Albert

in Journal of Physical Chemistry (1990), 94(13), 5293-5299

Solubility properties of the Eosin Y and Rose Bengal triplet states in aqueous solutions of sodium dodecyl sulfate have been explored by means of flash photolysis and electron paramagnetic resonance ... [more ▼]

Solubility properties of the Eosin Y and Rose Bengal triplet states in aqueous solutions of sodium dodecyl sulfate have been explored by means of flash photolysis and electron paramagnetic resonance techniques. Eosin Y triplet state does not associate with the surfactant aggregates while the Rose Bengal triplet state appears to be in dynamic equilibrium between the micellar and aqueous pseudophases. The corresponding equilibrium constant depends on the detergent concentration between the critical micelle concentration and about 60 mol dm-3. The exit rate constant of the Rose Bengal triplet state out of a micelle is found to decrease in this concentration range. This is attributed to an increase of the hydrophobic character of the sodium dodecyl sulfate micelle resulting from its partial dehydratation. Between 60 and 200 mmol dm-3, the equilibrium and exit rate constants seem to be constant. [less ▲]

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