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See detailSeduzione borghese e cultura dell'artificio. Femmes fatales in Oriani e Chelli
Curreri, Luciano ULg

in Italian Quarterly (1996), 129-130

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See detailCalcium et squelette, base physiologique d’une prévention
Reginster, Jean-Yves ULg

in Les Nouvelles de Rhumatologie (1996), 1

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See detailSpontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome.
Beguin, Yves ULg; Collignon, Jacques ULg; Laurent, C. et al

in British Journal of Haematology (1996), 94(3), 507-9

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a ... [more ▼]

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a relapse of his MDS with complete disappearance of donor haemopoiesis. After two episodes of CMV pneumonia and continued prophylactic use of ganciclovir thereafter, he experienced a spontaneous complete disappearance of all signs of MDS, including myelofibrosis, and a complete return to donor haemopoiesis. This case is the first one to suggest a graft-versus-leukaemia effect (GVL) in MDS patients. It depicts the complex relationship between GVL, graft-versus-host disease (GVHD) and graft rejection. It could also constitute a clinical illustration of the possible antileukaemic effect of CMV infection and its treatment with ganciclovir. [less ▲]

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See detailModelling the competition between two phytoplanktonic species
Elkafazi, Abderahman; Djenidi, Salim ULg; Nihoul, Jacques ULg

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailLes adénomes gonadotropes
Beckers, Albert ULg; Stevenaert, Achille ULg

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1996), 37(4-5), 299-305

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait ... [more ▼]

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait gonadotropes. Étant donné l'absente de symptomatologie spécifique, ils ne sont souvent reconnus que lorsqu'ils sont volumineux, ayant déjà entraîné un syndrome neurologique, une compression du chiasma optique. Dans la plupart des cas il est possible de les identifier grâce aux produits de sécrétion ou encore par méthodes d'immunohistochimie ou encore par la détection de l'ARN messager correspondant aux sous-unités hormonales. Le traitement reste essentiellement neuro-chirurgical (chirurgie trans-sphénoidale) car, dans la plupart des cas, les agonistes dopaminergiques et les analogues agonistes ou antagonistes de GnRH sont inefficaces. [less ▲]

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See detailAn efficient procedure for the production of fatty acid hydroperoxides from hydrolyzed flax seed oil and soybean lipoxygenase.
Fauconnier, Marie-Laure ULg; Marlier, M.

in biotechnology techniques (1996), 10(11), 839-844

Production of 13-linolenic acid hydroperoxides Tom hydrolyzed flax seed oil using lipoxygenase extracted Tom soybean seedshas been achieved with high transformation yields (60 g.l.-1h-1) with a high ... [more ▼]

Production of 13-linolenic acid hydroperoxides Tom hydrolyzed flax seed oil using lipoxygenase extracted Tom soybean seedshas been achieved with high transformation yields (60 g.l.-1h-1) with a high purity (94 % of i3-isomers) in a 10 liter reactor without addition of any solvent or surfactant. The reaction limiting factor is, probably, the accessibility of the substrate to the enzyme. [less ▲]

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See detailReturns Interval and Variability in Risk Measurement
Corhay, Albert ULg; Tourani Rad, Alireza

in Belgian Journal of Operations Research, Statistics and Computer Science = Revue Belge de Recherche Opérationnelle, de Statistique et d'Information (1996), 36

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See detailThe BFKL pomeron: Can it be detected?
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P. V.

in Nuclear Physics B (1996), 482

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See detailGrowth features and intergranular connectivity of melt processed YBCO
Lo, W.; Dewhurst, C. D.; Cardwell, D. A. et al

in Applied Superconductivity (1996), 4(10-11), 507-517

Large grain melt processed Y-Ba-Cu-O (YBCO) samples have been prepared by seeded and unseeded growth techniques. The current carrying ability within individual grains and across grain boundaries has been ... [more ▼]

Large grain melt processed Y-Ba-Cu-O (YBCO) samples have been prepared by seeded and unseeded growth techniques. The current carrying ability within individual grains and across grain boundaries has been investigated and correlated with features in the microstructure of samples fabricated by both techniques. The development of an inhomogeneous, cell-like growth microstructure in seeded samples at distances = 4 mm from the seed is related to a Saturation in inclusion density and volume proportion of Y2BaCuO5 (Y211) particles. A significant decrease in critical current density is associated with this change over a wide temperature range. The resistance of high angle c-axis grain boundaries is observed to depend critically on the magnitude of the injection current whereas the intragranular resistance is not influenced significantly by this variable. Jc of a grain boundary fabricated by unseeded melt growth is estimated to be less than 100 A cm(-2) at 77 K in zero applied field, which is more than two orders of magnitude lower than the intragranular Jc. Field screening measurements suggest that low angle grain boundaries do not form weak links between grains in modest magnetic fields and hence do not present a significant barrier to current flow. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailCrystallization and preliminary X-ray diffraction studies of a-amylase from the antarctic psychrophile Alteromonas haloplanctis A23
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (1996), 5(10), 2128-2129

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the ... [more ▼]

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the molecular basis of cold adaptations, crystallographic studies of this cold-adapted enzyme have been initiated because a three-dimensional structure of a mesophilic counterpart, pig pancreatic alpha-amylase, already exists. alpha-Amylase from A. haloplanctis, which shares 53% sequence identity with pig pancreatic alpha-amylase, has been crystallized and data to 1.85 A have been collected. The space group is found to be C222(1) with a = 71.40 A, b = 138.88 A, and c = 115.66 A. Until now, a three-dimensional structure of a psychrophilic enzyme is lacking. [less ▲]

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See detailPhénologie et domaine vital de la salamandre terrestre Salamandra salamandra terrestris (Amphibia, Caudata) dans un bois du Pays de Herve (Belgique)
Denoël, Mathieu ULg

in Cahiers d'Ethologie (1996), 16

The aim of this study was to approach some aspects of the life-history of the fire salamander Salamandra s. terrestris in a small wood of the Vesdre Valley (Liege Province, Belgium). In 1996, 189 ... [more ▼]

The aim of this study was to approach some aspects of the life-history of the fire salamander Salamandra s. terrestris in a small wood of the Vesdre Valley (Liege Province, Belgium). In 1996, 189 salamanders were marked and 68 recaptured. Their cartographic position and the meteorological conditions were noted. Salamanders were active from March to October, mated from May to August and females gave birth to larvae in March-April. Only a small part of the population was active at the same moment. Salamanders were generally faithful to a home range, in spite of some erratic individuals, and are apparently non-territorial. They moved principally along a path. The population is important but strongly threatened by the perturbation of its environment: stream drying, clearing and forest fire. [less ▲]

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See detailOne-pot enzymatic synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc sequence with in situ UDP-Gal regeneration.
Hokke, Cornelis H; Zervosen, Astrid ULg; Elling, Lothar et al

in Glycoconjugate Journal (1996), 13(4), 687-92

The trisaccharide Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was enzymatically synthesized, with in situ UDP-Gal regeneration. By combination in one pot of only four enzymes, namely ... [more ▼]

The trisaccharide Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was enzymatically synthesized, with in situ UDP-Gal regeneration. By combination in one pot of only four enzymes, namely, sucrose synthase, UDP-Glc 4'-epimerase, UDP-Gal:GlcNAc beta 4-galactosyltransferase and UDP-Gal:Gal beta 1-->4GlcNAc alpha 3-galactosyltransferase, Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was formed in a 2.2 mumol ml-1 yield starting from the acceptor GlcNAc beta 1-->O-(CH2)8COOCH3. This is an efficient and convenient method for the synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc epitope which pays an important role in various biological and immunological processes. [less ▲]

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See detailCoulomb interaction and ferroelectric instability of BaTiO3
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Europhysics Letters [=EPL] (1996), 33(9), 713-718

Using first-principles calculations, the phonon frequencies at the Gamma-point and the dielectric tensor are determined and analysed for the cubic and rhombohedral phases of BaTiO3. The dipole-dipole ... [more ▼]

Using first-principles calculations, the phonon frequencies at the Gamma-point and the dielectric tensor are determined and analysed for the cubic and rhombohedral phases of BaTiO3. The dipole-dipole interaction is then separated a la Cochran from the remaining short-range forces, in order to investigate their respective influence on lattice dynamics. This analysis highlights the delicate balance of forces leading to an unstable phonon in the cubic phase and demonstrates its extreme sensitivity to effective charge changes. Within our decomposition, the stabilization of the unstable mode in the rhombohedral phase or under isotropic pressure has a different origin. [less ▲]

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See detailA Non-Cofactor Role of Thiamine Derivatives in Excitable Cells?
Bettendorff, Lucien ULg

in Archives of Physiology & Biochemistry (1996), 104(6), 745-751

Thiamine diphosphate (TDP) is an important cofactor of pyruvate (PDH) and alpha-ketoglutarate (KGDH) dehydrogenases and transketolase. Thiamine deficiency leads to reversible and irreversible brain ... [more ▼]

Thiamine diphosphate (TDP) is an important cofactor of pyruvate (PDH) and alpha-ketoglutarate (KGDH) dehydrogenases and transketolase. Thiamine deficiency leads to reversible and irreversible brain lesions due to impaired oxidative metabolism. A specific non-cofactor role for thiamine has also been proposed in excitable cells and thiamine triphosphate (TTP) might be involved in the regulation of ion channels. Thiamine is taken up by neuroblastoma cells through a high affinity transporter. Inside the cells, it is rapidly phosphorylated to TDP. This high turnover TDP pool is the precursor for TTP. Most of the TDP however has a low turnover and is associated with PDH and KGDH in mitochondria. In excised inside-out patches from neuroblastoma cells, TTP, at a concentration of 1 microM, activates chloride channels of large unitary conductance, the so-called maxi-Cl- channels. These channels are inhibited by oxythiamine from the outide. In addition to the role of TTP in the regulation of chloride channels, thiamine itself, or a presently unknown analog, may have trophic effects on neuronal cells. [less ▲]

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See detailFusogenic Properties Of The C-Terminal Domain Of The Alzheimer Beta-Amyloid Peptide
Pillot, T.; Goethals, M.; Vanloo, B. et al

in Journal of Biological Chemistry (1996), 271(46), 28757-65

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was ... [more ▼]

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was investigated. These peptide domains were identified by computer modeling and correspond to respectively the C-terminal (e.g. residues 29-40 and 29-42) and a central domain (13-28) of the beta-amyloid peptide. The C-terminal peptides are predicted to insert in an oblique way into a lipid membrane through their N-terminal end, while the mutants are either parallel or perpendicular to the lipid bilayer. Peptide-induced vesicle fusion was demonstrated by several techniques, including lipid-mixing and core-mixing assays using pyrene-labeled vesicles. The effect of peptide elongation toward the N-terminal end of the entire beta-amyloid peptide was also investigated. Peptides corresponding to residues 22-42 and 12-42 were tested using the same techniques. Both the 29-40 and 29-42 beta-amyloid peptides were able to induce fusion of unilamellar lipid vesicles and calcein leakage, and the amyloid 29-42 peptide was the most potent fusogenic peptide. Neither the two mutants or the 13-28 beta-amyloid peptide had any fusogenic activity. Circular dichroism measurements showed an increase of the alpha-helical content of the two C-terminal peptides at increasing concentrations of trifluoroethanol, which was accompanied by an increase of the fusogenic potential of the peptides. Our data suggest that the alpha-helical content and the angle of insertion of the peptide into a lipid bilayer are critical for the fusogenic activity of the C-terminal domain of the amyloid peptide. The differences observed between the fusogenic capacity of the amyloid 29-40 and 29-42 peptides might result from differences in the degree of penetration of the peptides into the membrane and the resulting membrane destabilization. The longer peptides, residues 22-42 and 12-42, had decreased, but significant, fusogenic properties associated with perturbation of the membrane permeability. These data suggest that the fusogenic properties of the C-terminal domain of the beta-amyloid peptide might contribute to the cytotoxicity of the peptide by destabilizing the cell membrane. [less ▲]

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See detailMaladie pulmonaire obstructive chronique dans l'espèce équine
Vandenput, Sandrina ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Equine chronic obstructive pulmonary disease (COPD), also known as <<heaves>>, is a respiratory syndrome associated with stabling or exposure to hay or conditions in which molds or dust prevail. This ... [more ▼]

Equine chronic obstructive pulmonary disease (COPD), also known as <<heaves>>, is a respiratory syndrome associated with stabling or exposure to hay or conditions in which molds or dust prevail. This paper reviews the different aspects of the equine COPD. Etiology, potential evolutions, treatment and prevention of this disease are evolved. [less ▲]

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See detailMagnetic texturing of bulk samples of the superconductor Bi2Sr2Ca0.8Dy0.2Cu2O8-y
Stassen, Sophie; Rulmont, André ULg; Vanderbemden, Philippe ULg et al

in Journal of Applied Physics (1996), 79(1), 553-555

The texturing process of Bi-Sr-Ca(Dy)-Cu-O (2212) is optimized by sintering under a magnetic field. The precursor crystalline powder is melted and grown under a 1.2 T magnetic field. Textured samples are ... [more ▼]

The texturing process of Bi-Sr-Ca(Dy)-Cu-O (2212) is optimized by sintering under a magnetic field. The precursor crystalline powder is melted and grown under a 1.2 T magnetic field. Textured samples are characterized by x-ray diffraction, scanning electron microscopy, electrical resistivity, and magnetic susceptibility. (C) 1996 American Institute of Physics. [less ▲]

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See detailMiospore ranges near the D/C Boundary and extinction events.
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (1996), 12

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See detailCodon adjustment to maximise heterologous gene expression in Streptomyces lividans can lead to decreased mRNA stability and protein yield.
Lammertyn, E; Van Mellaert, L; Bijnens, A P et al

in Molecular & General Genetics [=MGG] (1996), 250(2), 223-9

The impact of the codon bias of the mouse tumour necrosis factor alpha (mTNF) gene cloned in Streptomyces lividans on the efficiency of expression and secretion was analysed. Minor codons occurring in the ... [more ▼]

The impact of the codon bias of the mouse tumour necrosis factor alpha (mTNF) gene cloned in Streptomyces lividans on the efficiency of expression and secretion was analysed. Minor codons occurring in the mTNF gene were therefore adapted to the codon bias of Streptomyces by site-directed mutagenesis. No improvement in mTNF yield could be detected. The stability of the transcript derived from the construct was shown to be more important for determining the final level of mTNF production. A strong correlation was observed between the yield of secreted biologically active mTNF and the amount of mTNF mRNA present in the cells. [less ▲]

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See detailGenetic aspects of abdominal aortic aneurysm.
VERLOES, Alain ULg; SakalihasanN, Natzi ULg; Limet, Raymond ULg et al

in Annals of the New York Academy of Sciences (1996), 800

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See detailComparaison des performances de porcs élevés sur litières ou sur caillebotis
Nicks, Baudouin ULg; Desiron, Alain; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1996), 140

In a first experiment, performances and carcass quality of fattening pigs kept either on a litter with sawdust, on straw or on slatted floor were compared. Three batches of 17 pigs were kept on each floor ... [more ▼]

In a first experiment, performances and carcass quality of fattening pigs kept either on a litter with sawdust, on straw or on slatted floor were compared. Three batches of 17 pigs were kept on each floor type. Pens with litter were not cleaned until the end of the third fattening period. On average 100 kg of sawdust or 49 kg of straw were used per pig. The growth rate of pigs on litters was higher (P < 0,01) than that of pigs on slatted floor : 739 g/d on sawdust, 745 g/d on straw and 686 g/d on slatted floor. Carcass quality at slaughter was not different according to the floor type. The peak shear force of the M. Longissimus dorsi was higher for pigs kept on straw than for the 2 other groups. In a second experiment, 97 weaners, 4 weeks old, were divided in 3 groups on 3 floor types : a deep litter with sawdust, a deep litter with sawdust mixed with straw and a slatted floor. Between 4 and 10 weeks of age, the growth rates of pigs were different (P < 0,05) according to the 2 litters : 438 g/d on the deep litter with straw and sawdust, 397 g/d on sawdust and higher (P < 0,001) than that on slatted floor (273 g/d). Pigs on slatted floor were however disadvantaged by a lower health status in the breeding pig house. [less ▲]

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See detailDémarche préventive d'une école du dos
Vanderthommen, Marc ULg; Drosson, C.; TOMASELLA, Marco ULg et al

in Kine 2000 (1996), 5(7),

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See detailWhere is the Algorithmic Support?
Wolper, Pierre ULg

in ACM Computing Surveys (1996), 28(4es), 58

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See detailNew Devonian fossil localities in Bolivia
Blieck, A; Gagnier, PY; Bigey, FP et al

in Journal of South American Earth Sciences (1996), 9(5-6), 295--308

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See detailRheinische Wortgeographie. Karten des Rheinischen Wörterbuchs und ihre computative Auswertung. Teil I
Lausberg, Helmut; Möller, Robert ULg

in Rheinische Vierteljahrsblätter (1996), 60

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See detailIsolation of nucleoli from ELT cells: a quick new method that preserves morphological integrity and high transcriptional activity.
Vandelaer, M.; Thiry, Marc ULg; Goessens, Guy ULg

in Experimental Cell Research (1996), 228(1), 125-31

We have developed a quick new method for isolating nucleoli which, unlike the methods in current use, preserves the nucleolar ultrastructure. Until now, the isolation process has generally been assumed to ... [more ▼]

We have developed a quick new method for isolating nucleoli which, unlike the methods in current use, preserves the nucleolar ultrastructure. Until now, the isolation process has generally been assumed to empty one of the three major compartments of the nucleolus, the fibrillar center, of its content. We have used the AgNOR staining and in vitro transcription assay to test the degree of structural and functional preservation of the isolated nucleoli. Our results demonstrate the value of our procedure as a reliable tool for biochemical and ultrastructural studies on the nucleolus. Moreover, these proprieties prompt us to investigate the rRNA synthesis, using a nonisotopic approach, within morphologically intact isolated nucleoli. Thus, we show that newly synthesized rRNA transcripts are located not only in the dense fibrillar component, but also indubitably in the fibrillar center. [less ▲]

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See detailVers une assurance qualité intégrée de la chaîne agro-alimentaire.
Vindevogel, Henri ULg; Daube, Georges ULg; Hans, J. C. et al

in Annales de Médecine Vétérinaire (1996), 140

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See detailIncidence du martelage sur l'exploitation mécanisée des premières éclaircies résineuses
Hebert, Jacques ULg; Lejeune, Philippe ULg; Van Belle, Jean-François et al

in Silva Belgica (1996), 103(6), 7-14

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See detailThe Coastal Ocean in a Global Change Perspective
Djenidi, Salim ULg

in Journal of Marine Systems (1996), 7(2-4), 117-118

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See detailChronic Exposure of Pigs to Airborne Dust and Endotoxins in an Environmental Chamber: Technical Note
Urbain, B.; Prouvost, J. F.; Beerens, Dominique ULg et al

in Veterinary Research (1996), 27(6), 569-578

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were ... [more ▼]

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were evaluated in a chamber containing two pigs of 10 kg body-weight: inhalable and respirable dust gravimetric concentrations were measured using area samplers and expressed as mg/m3. The respirable dust concentration was also measured using a "TM digital microP respirable dust-measuring instrument', which has been shown to give similar results to the gravimetric method. The endotoxin concentration was evaluated using the Limulus-assay and expressed as ng/m3 of air containing the inhalable or respirable dust or as ng/mg of inhalable and respirable dust. Feed flour dust was introduced into the chamber to obtain different concentrations of inhalable and respirable dust ranging from 3.62 to 76.66 mg/m3 and from 0.24 to 1.40 mg/m3, respectively. The endotoxin concentration was modulated by mixing the feed flour with Escherichia coli endotoxins before blowing it into the chamber. The endotoxin concentrations in the air containing inhalable or respirable dust ranged from 28.9 to 270.0 ng/m3 and from 2.22 to 36.38 ng/m3, respectively, depending on the amount of endotoxins added to the dust. Data were also obtained in a piggery. The experimental setup detailed in this paper could be used to study the significance of air contaminants in the development of pig respiratory diseases. [less ▲]

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See detailMise au point relative à l'utilisation de la gonadolibérine en reproduction bovine. 2. Domaines d'application clinique.
Hanzen, Christian ULg; Houtain, Jean Yves; Laurent, Yves

in Médecin Vétérinaire du Québec (1996), 26(2), 47-54

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See detailTribology in Aerospace Propulsion Mechanisms
Bozet, Jean-Luc ULg

in Space Scientific Research in Belgium, vol. IV : Space Technology (1996), 4

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See detailLong-term effects of androgen treatment on fear reactions in ewes.
Bouissou, Marie-France; Vandenheede, Marc ULg

in Hormones & Behavior (1996), 30

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See detailBenard-Marangoni instability in rigid rectangular containers
Dauby, Pierre ULg; Lebon, Georgy ULg

in Journal of Fluid Mechanics (1996), 329

Not Available

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See detailRadiosensitization in vitro by (E)-2′-(fluoromethylene)-deoxy-cytidine (FMdC), pentoxifylline (PTX) or a combination
Li; COUCKE, Philippe ULg; Paschoud et al

in International Journal of Radiation, Oncology, Biology, Physics (1996), 36(1 (supp1)), 383

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See detailAbsolute configuration of (R)-1-phenylethyl ammonium (S)-2-(6-methoxy-2-naphthyl)-propionate
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1996), C52

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See detailTwo stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12.
Satsangi, J.; Parkes, M.; Louis, Edouard ULg et al

in Nature Genetics (1996), 14(2), 199-202

Crohn's disease (CD) and ulcerative colitis (UC), the chronic inflammatory bowel diseases (CIBD), are common causes of gastro-intestinal disease in the Western world, with a combined prevalence of 100-200 ... [more ▼]

Crohn's disease (CD) and ulcerative colitis (UC), the chronic inflammatory bowel diseases (CIBD), are common causes of gastro-intestinal disease in the Western world, with a combined prevalence of 100-200/100,000 (ref. 1). Epidemiological studies, particularly concordance rates in twin pairs and siblings, strongly implicate genetic susceptibility in the pathogenesis of CIBD. In fact, the relative contribution of genetic factors to the pathogenesis of CD may be greater than in schizophrenia, asthma or hypertension, and at least equivalent to that in insulin-dependent diabetes. Systematic screening of the entire human genome now provides a strategy for the identification of susceptibility genes in complex polygenic disorders. We undertook a two-stage genome search for susceptibility genes in inflammatory bowel disease involving 186 affected sibling pairs from 160 nuclear families. We provide strong evidence for the presence of susceptibility loci for both CD and UC on chromosome 3, 7 and 12. We obtained the highest lod score (5.47; P = 2.66 x 10(-7) with the marker D12S83 and lod scores of 3.08 and 2.69 for D7S669 and D3S1573, respectively. Our data suggest that CD and UC are closely related, but distinct, polygenic disorders that share some, but not all, susceptibility genes. [less ▲]

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See detailImages liées à la pathologie traumatique du système nerveux central
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Acta Paediatrica Belgica (1996), 28(3), 216

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See detailVariations saisonnières du CO2 de l'air de deux grottes du Jura méridional: La Balme et Cerdon. Comparaison avec d'autres grottes françaises
Sbai, Abdelkader; Ek, Camille ULg; Renault, Philippe

in Annales de la Société Géologique de Belgique (1996), 119

Seasonal measurements of carbon dioxide were made over a period of one year in two caves from southern Jura: the caves of La Balme and of Cerdon. Carbon dioxide contents range from 300 to 15,500 ppm ... [more ▼]

Seasonal measurements of carbon dioxide were made over a period of one year in two caves from southern Jura: the caves of La Balme and of Cerdon. Carbon dioxide contents range from 300 to 15,500 ppm; these low values are correlated with the circulation of the air in the two caves and with the origin of the carbon dioxide. The values found in these caves are then compared with those measured by researchers in other French caves. [less ▲]

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See detailCaractéristiques paléontologiques des couches de transition Westphalien A/B dans le bassin de Campine (Sondage de Peer Kb206), Belgique.
Dusar, M.; Loboziak, S; Streel, Maurice ULg et al

in Sciences Géologiques. Bulletin (1996), 48

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See detailFirst synthesis of 4-substituted benzenesulfonylcyanoguanidines
Masereel, B.; Lebrun, P.; Dogne, J.-M. et al

in Tetrahedron Letters (1996), 37

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See detailInfections oculaires traumatiques et iatrogènes: prélèvements et rôle du laboratoire
Melin, Pierrette ULg

in Bulletin de la Société Belge d'Ophtalmologie (1996), 260

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological ... [more ▼]

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological diagnostic. The indications and techniques for investigations are determined by the site of infection, severity of the process, and knowledge of the likely responsible organisms. Immediate inoculation of specimens on culture media in the examining room is often recommended. This article describes organisms associated with ocular infections, and is designed to assists ophthalmologists in the collection, processing and transport of specimens. [less ▲]

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See detailEffect of some organophosphate insecticides on acetylcholinesterase of adult Coccinella septempunctata (Coccinellidae)
Bozsik, Andras; Haubruge, Eric ULg; Gaspar, Charles

in Journal of Environmental Science & Health. Part. B, Pesticides, Food Contaminants, & Agricultural Wastes (1996)

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See detailNew bisphosphonates for the treatment of osteoporosis : concerns and hopes
Reginster, Jean-Yves ULg

in Revue du Rhumatisme (English ed.) (1996), 63(7-8), 461-464

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See detailActivation of ATP-dependant K+ channels and inhibition of insulin release: effect of BPDZ 62
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Journal of Pharmacology and Experimental Therapeutics (The) (1996), 277

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See detailChronique de criminologie: Quels supporters pour l'an 2000?
Kellens, Georges ULg; Comeron, Manuel ULg

in Revue de Droit Pénal et de Criminologie (1996), (3), 306-312

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See detailHistorical seismicity of the Strait of Dover–Pas de Calais
Melville, Charles; Levret, Agnès; Alexandre, Pierre ULg et al

in Terra Nova (1996), 8

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See detailHumanitarian aid and health services in Eastern Kivu, Zaïre: collaboration or competition
Goyens, Philippe; Porignon, Denis ULg; Mugisho Soron'Gane, Etienne et al

in Journal of Refugee Studies (1996), 9(3), 268-280

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean ... [more ▼]

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean health services in the health districts of Rutshuru, Kirotshe and Masisi, in spite of the political and socioeconomic disintegration of the country, were still functioning, and the local hospitals and health centres, although overwhelmed, contributed to a large extent to the disaster response. Prominent among the major problems facing the local health services were their limited adaptability, the inadequate coordination and collaboration offered to them by the humanitarian aid agencies, and the discrimination between the direct and secondary victims of the emergency. The public health consequences of the Rwandan refugee crisis for the Zairean population constitute an integral part of the disaster. [less ▲]

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See detailEvaluation de l'effet apaisant d'un dermocosmétique: Soin intense apaisant
Nikkels, Arjen ULg; Jacquet, A.; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1996), 15

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation ... [more ▼]

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation and sites chromametry) and indirect investigations (corneocyte harvesting and chromametric analysis) have been conducted. The excellent correlation between the results has lead us to prove a very obvious soothing effect of SOIN INTENSE APAISANT (care range Hydrocapteur of Castalia, Laboratoires Lavipharm). [less ▲]

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See detailTheoretical Radiative Lifetimes of 3p3(4S°)4s5S° and 3S° States in S I
Biémont, Emile ULg; Storey, P. J.; Zeippen, C. J.

in Astronomy and Astrophysics (1996), 309

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See detail"Parce que je ne connais pas bien le grec..." (P. Col. Zen. II 66)
Rochette, Bruno ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1996), 71(142), 311-316

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See detailA novel three-enzyme reaction cycle for the synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose
Zervosen, Astrid ULg; Elling, Lothar

in Journal of the American Chemical Society (1996), 118(8), 1836-1840

A new three-enzyme reaction cycle consisting of sucrose synthase, UDP glucose 4‘-epimerase, and human β-1,4-galactosyltransferase was established for the synthesis of N-acetyllactosamine (LacNAc) with in ... [more ▼]

A new three-enzyme reaction cycle consisting of sucrose synthase, UDP glucose 4‘-epimerase, and human β-1,4-galactosyltransferase was established for the synthesis of N-acetyllactosamine (LacNAc) with in situ regeneration of UDP galactose. We found that UDP glucose 4‘-epimerase is reductively inactivated in the presence of UMP and acceptor substrates of β-1,4-galactosyltransferase. Reactivation of UDP glucose 4‘-epimerase by the transition state analogues dUDP or dTDP 6-deoxy-d-xylo-4-hexulose in combination with the repetitive batch technique enabled us to use the native enzymes for 11 days in this cycle. With 10 U of sucrose synthase, 5 U of UDP glucose 4‘-epimerase, and 1.25 U of β-1,4-galactosyltransferase, 594 mg of LacNAc could be synthesized. N-Acetyllactosamine was also subsequently converted to Neu5Acα2,6Galβl,4GlcNAc with α-2,6-sialyltransferase and CMP-Neu5Ac. [less ▲]

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See detailNutritional and animal husbandry aspects of rearing early life stage of Eurasian perch Perca fluviatilis
Kestemont, Patrick; Mélard, Charles ULg; Fiogbe, Emile et al

in Journal of Applied Ichthyology (1996), 12

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See detailCombined enzymatic synthesis of nucleotide (deoxy) sugars from sucrose and nucleoside monophosphates
Zervosen, Astrid ULg; Stein, Andreas; Adrian, Holger et al

in Tetrahedron (1996), 52(7), 2395-2404

Abstract: The synthesis of NDP-glucose 3a-d (N= A, C, U, dU) with sucrose synthase B was combined with the enzymatic synthesis of nucleoside diphosphates 2a-d from their corresponding nucleoside ... [more ▼]

Abstract: The synthesis of NDP-glucose 3a-d (N= A, C, U, dU) with sucrose synthase B was combined with the enzymatic synthesis of nucleoside diphosphates 2a-d from their corresponding nucleoside monophosphates la-d by different kinases A. Further combination with recombinant dTDP-glucose 4,6-dehydratase D enabled us to synthesize dUDP-6-deoxy-alpha-D-xylo-4-hexulose 5 from ld on a preparative scale. By using the repetitive batch technique the enzymatic syntheses of nucleotide (deoxy) sugars 3a-d, 5 could be realized on a 0.1 - 0.5 g scale. [less ▲]

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See detailDissociation of increases in plasma insulin-like growth factor I and testosterone during the onset of puberty in bulls
Renaville, Robert ULg; Massart, Serge; Sneyers, M. et al

in Journal of Reproduction and Fertility (1996), 106(1), 79-86

The present study was conducted to examine the relationship between plasma concentrations of testosterone, insulin-like growth factor I (IGF-I) and IGF-binding proteins (IGFBPs) during puberty, in male ... [more ▼]

The present study was conducted to examine the relationship between plasma concentrations of testosterone, insulin-like growth factor I (IGF-I) and IGF-binding proteins (IGFBPs) during puberty, in male calves treated with GnRH or testosterone propionate. Twelve male Holstein calves (10 weeks old) were assigned to the control group (n = 6), the GnRH-treated group (n = 3) or the testosterone-treated group (n = 3). For 8 weeks, the GnRH-treated group received a single i.v. injection of GnRH (0.5 mu g kg(-1) body mass) each day while the testosterone-treated group received an i.m. injection of testosterone propionate (0.5 mg kg(-1) body mass) twice a day. The calves were studied until they were 200 days old. Hormone treatments were stopped one month after puberty was reached in the control group. Blood samples were collected every 30 min for 8 h every third day. Hormone concentrations were determined by radioimmunoassay. Western ligand blotting and immunoblotting, using monoclonal antibodies against IGFBP-2, and IGFBP-3, were used to characterize the IGF-binding proteins. In the control group, puberty occurred at about 120 days of age and was associated with an increase in concentrations of testosterone, IGF-I and IGFBP-3 and a decrease in concentration of IGFBP-2. In the GnRH-treated group, plasma testosterone remained low until 8 weeks after establishment of puberty in the control group (4 weeks after the end of treatment). In the testosterone-treated group, testosterone was high during the treatment period and then decreased to prepubertal values when treatment was stopped. Testosterone values increased again to reach postpubertal values 5 weeks after the end of hormone treatment. Nevertheless, independent of testosterone status, the profile of IGF-I and the IGFBPs in the GnRH- and testosterone-treated groups were parallel to that reported for the control group with the transition from prepubertal to adult values at about 120 days of age. In conclusion, concentrations of testosterone, IGF-I and IGFBP-3 increase together, but probably independently, during the onset of puberty in male calves. [less ▲]

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See detailLessons from the discovery of leptin: is obesity an endocrine disease?
Scheen, André ULg

in Acta Clinica Belgica (1996), 51(6), 371-6

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See detailPseudoaneurisma gigante del ventriculo izquierdo
Olivieri, E.; Guessaghi, R.; Chavin, A. et al

in Prensa Medica Argentina (1996), 83(10), 919-924

A 85 years old patient was hospitalized because of thoracic pain, lasting since three months. He suffered of Parkinson's disease and he was a smoker. The pain increased with cough and Vansalva's test. His ... [more ▼]

A 85 years old patient was hospitalized because of thoracic pain, lasting since three months. He suffered of Parkinson's disease and he was a smoker. The pain increased with cough and Vansalva's test. His left arm was cianotic. An arterial obstruction was suspected. Dopler ultrasound of the left arm confirmed a partial obstruction of the left axillar artery. Surprisingly, thoracic scan and MRI found an important cardiomegaly. The heart was in contact with the diaphragmatic and gastric region. Ecocardiography confirmed a 7 cm pseudo aneurysm of the left ventricle. Coronarography showed extreme hypokinesia of the left ventricle. There was also an obstruction of the right coronary and 50 % stenosis of the left coronary. Pseudo aneurysm was a complication of myocardial infarction of the left ventricle. Surgery was offered to the patient, but he declined the intervention. He was dismissed with medical treatment and anticoagulation. The patient deceased three months later. [less ▲]

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See detailAtomic data from the IRON Project. XIX. Radiative transition probabilities for forbidden lines in Fe II
Quinet, Pascal ULg; Le Dourneuf, M; Zeippen, C J

in Astronomy and Astrophysics. Supplement Series (1996), 120

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See detailHeparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells.
Incardona, F.; Lawler, J.; Cataldo, Didier ULg et al

in Journal of Cellular Biochemistry (1996), 62(4), 431-42

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains ... [more ▼]

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains of thrombospondin that mediate its binding to specific receptors on the human breast adenocarcinoma cell line, MDA-MB-231. Two recombinant fragments from the amino-terminus (TSPN18 and TSPN28), and the fusion proteins of the type 1 and type 2 repeats of human thrombospondin, inhibited binding of radiolabeled thrombospondin to MDA-MB-231 cells in suspension by 40-60% at 50 micrograms/ml whereas the type 3 repeat, carboxy-terminus and unfused glutathione-S-transferase as well as the synthetic peptide Gly-Arg-Gly-Asp-Ser (500 micrograms/ml) had little or no effect. Heparin and various glycosaminoglycans as heparan sulfate, chondroitin sulfates A, B or C, and fucoidan inhibited thrombospondin binding to MDA-MB-231 cells by more than 60% whereas dextran sulfate had only little effect. Treatment of cells with heparitinase, chondroitinase ABC, and hyaluronidase, but not with neuraminidase, induced 30-50% inhibition of thrombospondin binding suggesting the participation of both heparan sulfate and chondroitin sulfate cell surface-associated molecules. Inhibition of proteoglycan sulfation by chlorate or inhibition of glycosaminoglycan chain formation by two beta-D-xylosides also led to a substantial inhibition of thrombospondin binding. Our results indicate that several domains within the thrombospondin molecule, namely the amino-terminus, type 1 and type 2 repeats, participate in its binding to specific receptors bearing sulfated glycosaminoglycans on MDA-MB-231 cells. Biological assays have indicated that, in addition to these domains, the peptide Gly-Arg-Gly-Asp-Ser inhibited MDA-MB-231 cell attachment to thrombospondin suggesting that the last type 3 repeat of the molecule may also contribute to its cell adhesive activity. [less ▲]

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See detailAnatomie des monticules micritiques du Frasnien belge et contexte eustatique
Boulvain, Frédéric ULg; Herbosch, A.

in Bulletin de la Société Géologique de France (1996), 167(3), 391-398

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See detailDistribution of inorganic carbon and related parameters in surface waters of the English Channel during spring 1994
Frankignoulle, Michel; Elskens, Marc; Biondo, Renzo ULg et al

in Journal of Marine Systems (1996), 7

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See detailAssureurs et prédations: Les développements de l'assurance contre le vol en France
Lemaître, André ULg

in Les Cahiers de la Sécurité Intérieure (1996), N°25

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See detailStromelysin-3 in the biology of normal and tumoral mammary gland.
Rio, M. C.; Lefebvre, O.; Santavicca, M. et al

in Journal of Mammary Gland Biology & Neoplasia (1996), 1(2), 231-240

Stromelysin-3 (ST3) is an extracellular proteinase predominantly expressed in fibroblasts. The particular structural features andin vitro functions of this molecule suggest it could be the first member of ... [more ▼]

Stromelysin-3 (ST3) is an extracellular proteinase predominantly expressed in fibroblasts. The particular structural features andin vitro functions of this molecule suggest it could be the first member of a new subgroup of the matrix metalloproteinase family. ST3 is transiently expressed during mammary gland post-weaning involution, embryonic implantation, various organogeneses, and during amphibian metamorphosis. Moreover, ST3 is expressed in a panel of human invasive carcinomas including breast, colon, and head and neck carcinomas. Almost all ST3-expressing tissues show intense extracellular matrix remodeling activities including the loss of basement membrane integrity. Thus, either directly, or indirectly in association with other proteinases, ST3 might be involved in tissue remodeling processes occurring in both physiological and pathological processes.In vitro andin vivo studies using malignant cells stably transfected in such a way as to modulate their ST3 expression levels indicate that ST3 modifies neither cell proliferation nor invasive properties, but rather favors tumor cell survival in host tissues. This hypothesis is consistent with clinical data showing that ST3 expression could be predictive of tumor progression leading to metastases. [less ▲]

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See detailDéveloppement actuel du concept de l'hygiène en agro-alimentaire et des exigences des normes européennes.
Vindevogel, Henri ULg; Daube, Georges ULg; Hans, J. C. et al

in Annales de Médecine Vétérinaire (1996), 140

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See detailFinite element modelling of the competition between shear bands in the early stage of thrusting : Strain localisation and constitutive law influence
Barnichon, Jean-Dominique; Charlier, Robert ULg

in Special Publication - Geological Society of London (1996), 99

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See detailCloning and expression of a new HOXC6 transcript encoding a repressing protein
Chariot, Alain ULg; Castronovo, Vincenzo ULg; Le, P. et al

in Biochemical Journal (1996), 319

Homeodomain-containing proteins are transcription factors that regulate the co-ordinated expression of multiple genes involved in development, differentiation and malignant transformation. In an attempt ... [more ▼]

Homeodomain-containing proteins are transcription factors that regulate the co-ordinated expression of multiple genes involved in development, differentiation and malignant transformation. In an attempt to characterize expressed homeobox (HOX) genes in breast cancer cells, we cloned two distinct HOXC6 transcripts from an MCF7 cDNA library, Interestingly, one of them represents a new HOXC6 mRNA encoding a homeodomain-containing protein harbouring a unique N-terminal sequence. Moreover we demonstrate that this HOXC6 transcript is less abundant in human breast cancer cells than in non-tumorigenic cell lines, is detected in breast carcinomas and adjacent tissues and is expressed in a variety of human tumours. In addition, transient co-transfection experiments illustrated that both HOXC6 transcripts encode gene products that repress transcription from a HOX binding sequence in MDA-MB231 cells and co-operate with other HOX gene products such as HOXB7 on their target genes. Taken together, our results suggest that HOXC6 proteins might contribute to the breast cell phenotype through co-operative interactions with other HOX-derived proteins and repression of their target genes. [less ▲]

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See detailAlterations in the ultradian oscillations of insulin secretion and plasma glucose in aging.
Scheen, André ULg; Sturis, J.; Polonsky, K. S. et al

in Diabetologia (1996), 39(5), 564-72

Normal insulin secretion includes oscillations with a period length of 80-150 min which are tightly coupled to glucose oscillations of similar period. To determine whether normal aging is associated with ... [more ▼]

Normal insulin secretion includes oscillations with a period length of 80-150 min which are tightly coupled to glucose oscillations of similar period. To determine whether normal aging is associated with alterations in these ultradian oscillations, eight, modestly overweight, older men (65 +/- 5 years) and eight weight-matched young control subjects (25 +/- 4 years) were studied during 53 h of constant glucose infusion. Blood samples were collected every 20 min and insulin secretion rates were calculated by deconvolution. Ultradian oscillations of glucose and insulin secretion were evident in both groups. Pulse frequency was similar for glucose and insulin secretion, and was not affected by age. The absolute amplitude of the glucose oscillations was similar in both groups but their relative amplitude was slightly dampened in the older adults. Both the absolute and the relative amplitudes of insulin secretory oscillations were markedly reduced in the older subjects. The normal linear increase in the amplitude of insulin oscillations occurring with increasing amplitudes of glucose oscillations was still present in the older adults but analysis of covariance indicated that the slope was significantly lower than in the young control subjects (p < 0.0005), reflecting a decreased responsiveness of the beta cell to glucose changes. The temporal concordance between insulin and glucose oscillations, as estimated by pulse concomitancy and cross-correlation, was also lower in older subjects. The similarities between the alterations in the ultradian oscillations of insulin secretion and glucose in older healthy adults and those occurring in diabetic patients suggest that an impairment of beta-cell function may play a primary role in the deterioration of glucose tolerance in aging. [less ▲]

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See detailEvaluation of insulin-like growth factor-I and its plasma binding proteins in pigs.
Renaville, Robert ULg; Prandi, A.; Claes, Victor et al

in Archivio Veterinario Italiano (1996), 46

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See detailEffets toxiques de l’ozone atmosphérique sur le système respiratoire. Brève revue des connaissances actuelles
Delaunois, A.; Gustin, Pascal ULg; Nemmar, R. et al

in Annales de Médecine Vétérinaire (1996), 140

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See detailOn the structure of liquid tellurium
Bichara, C.; Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg

in Journal of Non-Crystalline Solids (1996), 205-207

The atomic structure and the bonding mechanism in liquid tellurium are investigated by a tight binding Monte Carlo technique. The chain structure is preserved but a third covalent bond emerges with an ... [more ▼]

The atomic structure and the bonding mechanism in liquid tellurium are investigated by a tight binding Monte Carlo technique. The chain structure is preserved but a third covalent bond emerges with an intermediate interatomic separation (3.15 Aring). In addition a bond length alternation inside the chain appears in agreement with recent EXAFS experiments and the valence angles are significantly reduced. The electronic structure is studied and particular attention is paid to the modifications of lone pair interactions in the liquid structure [less ▲]

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See detailLa titanite de Bastogne (Belgique) et les minéraux associés
Hatert, Frédéric ULg; Fransolet, André-Mathieu ULg; Houssa, Michel

in Bulletin de la Société Royale des Sciences de Liège (1996), 65(6), 387-397

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See detailActualités thérapeutiques dans la thrombocytémie essentielle
Hermanne, J.-P.; Tassin, F.; Beguin, Yves ULg et al

in Médecine et Hygiène (1996), 54

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of ... [more ▼]

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of thrombocythaemia is controversial. Since th relationship of thrombosis and hemorrhage to platelet counts is not demonstrated, ther is no clear inidcation for using drugs capable of lowering platelet counts in young asymptomatic subjects. However, treatment should be offered to patients with a definite high risk of major or life-threatening hemostatic complications. The present paper reviews the incidence and risk factors for thrombotic complications and the use of medications inhibiting platelet production. [less ▲]

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See detailThe Neoproterozoic Pan-African basement from the Alpine Lower Danubian nappe system (South Carpathians, Romania)
Liégeois, Jean-Paul ULg; Berza, Tudor; Tatu, Mihai et al

in Precambrian Research (1996), 80

The South Carpathians, which were thrust to the Moesian platform in the Alpine orogeny (Late Cretaceous to Tertiary), include the Danubian nappe system. The Danubian pre-Alpine basement comprises two ... [more ▼]

The South Carpathians, which were thrust to the Moesian platform in the Alpine orogeny (Late Cretaceous to Tertiary), include the Danubian nappe system. The Danubian pre-Alpine basement comprises two Variscan nappes, each one made up of partially retrogressed amphibolite facies rocks intruded by granitoids and capped by an Ordovician-Devonian volcano-sedimentary cover. No lithological correlation can be established between the pre-Ordovician basements of these two units. The metamorphic basement from the first Variscan nappe, the Drãgºan Group, is composed of banded amphibolites with some augen and aluminous gneisses intruded by granodioritic to tonalitic plutons. The banded structure of the amphibolites, together with their geochemistry, suggests a volcano-sedimentary sequence. Zircon U-Pb data on an intercalated augen gneiss have given an age of 777 ± 3 Ma for the emplacement of the protolith of this gneiss. Nd model ages (TDM) for the amphibolites range from 717 Ma to 817 Ma. At 777 Ma, Nd values cluster is at +8.3 to +9.8 and Sr initial ratios range between 0.7007 and 0.7023, indicating an oceanic origin without continental crust contamination. Major and trace elements from the Drãgºan amphibolites consistently display an island arc signature, with three differentiation trends evolving from an early tholeiitic trend to a more differentiated low-K calc-alkaline one. The Drãgºan terrane is similar to the Early Pan-African juvenile terranes of the Sahara. The basement of the second Variscan nappe, the Lainici-Pãiuº Group, is made up of metasedimentary rocks (mainly quartzites, marbles and graphitic mica gneisses) cut by early leucogranitic dykes, medium-K calc-alkaline and alkali-calcic (mainly granitic) plutons, and late medium-K porphyry diorite dykes. This magmatism can be bracketed between 588 Ma and 567 Ma (U-Pb zircon ages). The best preserved pluton (Tismana, 567 Ma old), displays a composite alkali-calcic (very high-K calc-alkaline) magmatic sequence, ranging from gabbro-diorite to monzogranite, including an ultramafic pod. Ages and geochemical signatures resemble the Saharan Late Pan-African granitoids. The existence of Late Precambrian partly juvenile terrains is thus confirmed within the basement of South Carpathians, which renders then a segment of the European Alpine belt that can be successfully compared to the Pan-African Trans-Saharan belt. [less ▲]

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See detailMechanism of Single-Electron Capture by the Dichlorocarbene Dication.
Leyh, Bernard ULg; Hautot, D.

in Journal of the American Society for Mass Spectrometry (1996), 7

The single-electron capture (SEC) by dichlorocarbene with eight different atomic and molecular target gases, (CCl2)2++G->(CCl2)++G+, has been studied by product ion spectroscopy and ion kinetic energy ... [more ▼]

The single-electron capture (SEC) by dichlorocarbene with eight different atomic and molecular target gases, (CCl2)2++G->(CCl2)++G+, has been studied by product ion spectroscopy and ion kinetic energy spectroscopy. The experimental data have been interpreted in the framework of a theoretical model that describes the charge exchange process. Exothermic charge exchange is handled within the Landau-Zener model, whereas endothermic charge exchange is described by the Demkov model. The calculated data reproduce qualitatively the essential features of the experimental results: (1) the appearance of a reaction window centered at an exothermicity in the 4-4.5 eV range, (2) the lower SEC cross sections for endothermic charge exchange, (3) the wider internal energy distributions obtained for CCl2+ in the endothermic regime than in the exothermic one, which results in larger dissociation yields, (4) the excitation of molecular targets that accompany their ionization in the SEC process, and (5) the kinetic energy released on the CCl++Cl fragments in dissociative SEC. [less ▲]

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See detailQuantitative Densitometric Evaluation of Harpagoside in the Secondary Roots of Harpagophytum procumbens D.C.
Poukens-Renwart, Pascale; Tits, Monique ULg; Angenot, Luc ULg

in Journal of Planar Chromatography- Modern TLC (1996), 9(May/June), 199-202

Harpagophytum procumbens D.C. (Devil's Claw) secondary roots are used in Europe as a home remedy for lack of appetite, dyspeptic complaints, and in supportive therapy for degenerative disorders of the ... [more ▼]

Harpagophytum procumbens D.C. (Devil's Claw) secondary roots are used in Europe as a home remedy for lack of appetite, dyspeptic complaints, and in supportive therapy for degenerative disorders of the locomotor system. The main characteristic iridoid glucoside of the plant is harapagoside. An HPTLC method has been developed for the quantitative determination of harpagoside in the secondary roots and extracts of this plant. The mobile phase used is an optimized version of one described in the literature.It furnished the most homogenous spots for quantitative densitometric evaluation ( at lambda= 286 nm, the wavelenght of maximum absorption for harapgoside).The results have been compared with those obtained afetr visualization with sulfuric acid-vanillin reagent and those obtained using a previously published HPLC method; To check that separation was complete, the spectra of harpagoside obtained from Devil's Claw extracts before and after visualization were superimposed on thos of harpagoside standard. [less ▲]

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See detailTreatment of osteoporosis
Reginster, Jean-Yves ULg

in Medycina Po Dyplomie (1996)

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See detailDeficient Habituation of Evoked Cortical Potentials in Migraine: A Link between Brain Biology, Behavior and Trigeminovascular Activation?
Schoenen, Jean ULg

in Biomedicine & Pharmacotherapy (1996), 50(2), 71-8

According to recent evoked potential studies, a fundamental, probably protective, feature of cortical information processing, ie, response habituation during stimulus repetition, is abnormal in migraine ... [more ▼]

According to recent evoked potential studies, a fundamental, probably protective, feature of cortical information processing, ie, response habituation during stimulus repetition, is abnormal in migraine between attacks. The deficient habituation is found for different sensory modalities and experimental paradigms: pattern-reversal visual evoked potentials (same stimulus at a constant intensity), cortical auditory evoked potentials (same stimulus at increasing intensities) and auditory event-related potentials obtained in a passive "oddball" paradigm (novel stimulus). The abnormal information processing is an interictal cortical dysfunction most likely due to inadequate control by the so-called "state-setting, chemically-addressed pathways" originating in the brain stem, in particular by the serotonergic pathway, leading to a low preactivation level of sensory cortices. We suggest that it may play a pivotal role in migraine pathogenesis in conjunction with the reported decrease of brain mitochondrial energy reserve, by favouring a rupture of metabolic homeostasis and biochemical shifts capable of activating the trigeminovascular system and thus capable of producing a migraine attack. We postulate that both the deficient habituation in information processing and the deranged oxygen metabolism may have behavioral correlates. Which of these abnormalities are inherited, acquired or both remains to be determined. [less ▲]

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See detailDensitometric Evaluation of Gentiopicroside in the Roots of Gentiana lutea L.
Bodart, Patricia; Poukens-Renwart, Pascale; Wauters, Jean-Noël ULg et al

in Journal of Planar Chromatography- Modern TLC (1996), 9(March/April), 143-145

As no satisfactory method existed for the separation of gentiopicroside from other components of gentian roots, we have decided to undertake some experiments.In this communication, we report the use of a ... [more ▼]

As no satisfactory method existed for the separation of gentiopicroside from other components of gentian roots, we have decided to undertake some experiments.In this communication, we report the use of a novel mobile phase and a different detection system. Our HPTLC method is a fast and reliable procedure which may be used for quantification of gentiopicroside in roots and extracts of Gentiana lutea, whether for routine analysis or for studying stability. The TLC method is also compared with an HPLC method. [less ▲]

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See detailThiamine, Thiamine Phosphates, and Their Metabolizing Enzymes in Human Brain
Bettendorff, Lucien ULg; Mastrogiacomo, Frank; Kish, Stephen J et al

in Journal of Neurochemistry (1996), 66(1), 250-8

Total thiamine (the sum of thiamine and its phosphate esters) concentrations are two- to fourfold lower in human brain than in the brain of other mammals. There were no differences in the total thiamine ... [more ▼]

Total thiamine (the sum of thiamine and its phosphate esters) concentrations are two- to fourfold lower in human brain than in the brain of other mammals. There were no differences in the total thiamine content between biopsied and autopsied human brain, except that in the latter, thiamine triphosphate was undetectable. The main thiamine phosphate-metabolizing enzymes could be detected in autopsied brain, and the kinetic parameters were comparable to those reported in other species. Thiamine diphosphate levels were lowest in hippocampus (15 +/- 4 pmol/mg of protein) and highest in mammillary bodies (24 +/- 4 pmol/mg of protein). Maximal levels of thiamine and its phosphate ester were found to be present at birth. In parietal cortex and globus pallidus, mean levels of total thiamine in the oldest age group (77-103 years) were, respectively, 21 and 26% lower than those in the middle age group (40-55 years). Unlike cerebral cortex, the globus pallidus showed a sharp drop in thiamine diphosphate levels during infancy, with concentrations in the oldest group being only approximately 50% of the levels present during the first 4 months of life. These data, consistent with previous observations conducted in blood, suggest a tendency toward decreased thiamine status in older people. [less ▲]

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See detailThe Creb, Atf-1, And Atf-2 Transcription Factors From Bovine Leukemia Virus-Infected B Lymphocytes Activate Viral Expression
Adam, E.; Kerkhofs, P.; Mammerickx, M. et al

in Journal of Virology (1996), 70(3),

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See detailComment les professeurs de mathématiques évaluent-ils leurs élèves ?
Demonty, Isabelle ULg; Detheux-Jehin, M.; Vlassis, Joëlle ULg

in Informations Pédagogiques (1996), 27

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See detailEnantioselective syntheses of no-carrier-added (nca) (S)-4-chloro-2 F-18 fluorophenylalanine and (S)-(alpha-methyl)-4-chloro-2 F-18 fluorophenylalanine
Al-Darwich, M. J.; Plenevaux, Alain ULg; Lemaire, Christian ULg et al

in Journal of Fluorine Chemistry (1996), 80(2), 117-124

(S)-4-Chloro-2-fluorophenylalanine and (S)-( a-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on ... [more ▼]

(S)-4-Chloro-2-fluorophenylalanine and (S)-( a-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F] fluorobenzyl iodide and the lithium enolate of (2s) -1-( tert-butyloxycarbonyl) -2-( tert-butyl)-3-methyl- 1,3-imidazolidine-4-one for (S) -4-chloro-2- [18F] fluorophenylalanine and (2S,5S)-1-( tert-butyloxycarbonyl) -2-( tert-butyl) -3,5-dimethyl- 1,3-imidazolidine-4-one for (S) -( a-methyl) -4-chloro-2- [18F] fluorophenylalanine. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatography (HPLC) purification, with a radiochemical yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F] fluoride. The enantiomeric excesses were shown to be 97% or more for both molecules without chiral separation and the radiochemical and chemical purities were 98% or better. [less ▲]

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See detailCytokine gene polymorphisms in inflammatory bowel disease.
Louis, Edouard ULg; Satsangi, J.; Roussomoustakaki, M. et al

in Gut (1996), 39(5), 705-10

BACKGROUND: Concordance rates in siblings and twins provide strong evidence that genetic susceptibility is important in the pathogenesis of inflammatory bowel disease. The number and identity of ... [more ▼]

BACKGROUND: Concordance rates in siblings and twins provide strong evidence that genetic susceptibility is important in the pathogenesis of inflammatory bowel disease. The number and identity of susceptibility genes is largely uncertain. Cytokine genes are attractive candidate loci. AIMS: To study allelic frequencies of polymorphisms of the interleukin-1 receptor antagonist (IL-1RA) gene and the tumour necrosis factor alpha gene in patients with inflammatory bowel disease. SUBJECTS: One hundred and twenty nine North European caucasoid patients with ulcerative colitis, 120 patients with Crohn's disease, and 89 healthy controls. METHODS: Genotyping was performed by polymerase chain reaction. A variable number of tandem repeats (VNTR) in the IL-1RA gene and a single base pair polymorphism in the TNF alpha gene promoter region (TNF-308) were analysed. RESULTS: No significant differences in IL-1RA VNTR allelic frequencies were noted between Crohn's disease (allele 1: 72.6%, allele 2: 24.7%, allele 3: 2.6%), ulcerative colitis (72.6%, 24.3%, 3.1%, respectively), and controls (76.9%, 20.8% and 2.3%). Some 42.4% of patients with ulcerative colitis and 43.4% patients with Crohn's disease were carriers of allele 2, compared with 34.8% healthy subjects. The TNF2 allele was modestly reduced in Crohn's disease (13.2%), compared with healthy subjects (21.3%; p = 0.04), and ulcerative colitis (21.6%). CONCLUSIONS: The associations demonstrated are modest: these polymorphisms are unlikely to be important determinants of overall disease susceptibility. [less ▲]

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See detailStandardisation des mesures en imagerie thermique infrarouge chez les grands animaux domestiques
Ghafir, Y.; Spruyt, P.; Art, Tatiana ULg et al

in Annales de Médecine Vétérinaire (1996), 140

Thermography studies pictures recorded from radiant thermal emissions of a body. This paper analyses several measurement conditions in order to make thermographic unit reliable, ie the effects of distance ... [more ▼]

Thermography studies pictures recorded from radiant thermal emissions of a body. This paper analyses several measurement conditions in order to make thermographic unit reliable, ie the effects of distance and position of the camera, the color, lenght and power. Moreover, the effects of the site on cutaneous temperature measurements were studied in exercising horses. It can be concluded that infrared thermography is a technical to measure skin temperature which requires a few conditions to be respected. Moreover, it is a sure, simple and fast method. The ideal site for measuring skin temperature inexercising horses is the neck because of its vascularisation. [less ▲]

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See detailAugustus Latinus. Purisme, pouvoir, politique et idéologie sous Auguste
Rochette, Bruno ULg

in Bulletin de l'Institut Historique Belge de Rome (1996), 66

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See detailDes pèlerins latins en Terre Sainte. Rencontre de langues et de cultures
Rochette, Bruno ULg

in Byzantion : Revue Internationale des Etudes Byzantines (1996), 66

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See detailComposition of the essential oil of Piper acutifolium Ruiz. and Pav. from Peru.
Lognay, Georges ULg; Bouxin, P.; Marlier, M. et al

in Journal of Essential Oil Research (1996), 8(6),

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See detailBequest motives and the level and composition of wealth in Belgium. A survey based analysis
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Cahiers Economiques de Bruxelles (1996), (149), 31-53

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See detailAcrylonitrile on Cu(100): a density functional theoretical study of adsorption and electrochemical grafting
Geskin, V. M.; Lazzaroni, Roberto; Mertens, Marc et al

in Journal of Chemical Physics (1996), 105(8), 3278-3289

We present a density functional theoretical study of neutral and negatively charged complexes of acrylonitrile (AN) with several clusters representing the Cu(100) surface. An external electric field is ... [more ▼]

We present a density functional theoretical study of neutral and negatively charged complexes of acrylonitrile (AN) with several clusters representing the Cu(100) surface. An external electric field is used to induce electron transfer onto the adsorbed molecule, in order to model the initial stage of electrochemical polymerization of AN on a copper electrode. We compare different possibilities of AN interaction with the metal and determine the most favorable configurations of the adsorbates in the absence and in the presence of the electric field. We discuss the influence of the electrochemical polarization on the type of AN adsorption, in relation with the experimental data on the adsorption of AN and electrochemical grafting of polyacrylonitrile. [less ▲]

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See detailManifestaciones cardiovasculares en el SIDA
Valdes, E. F.; Rostello, E.; Villanueva, H. R. et al

in Prensa Medica Argentina (1996), 83

Cardiovascular complications in acquired immunodeficiency syndrome. AIDS miocardiopathy has been described since 1983. Physiopathologic events leading to AIDS myocardiopathy are largely unknown: viral ... [more ▼]

Cardiovascular complications in acquired immunodeficiency syndrome. AIDS miocardiopathy has been described since 1983. Physiopathologic events leading to AIDS myocardiopathy are largely unknown: viral miocardiopathy, cytokines induced lesions, nutritional status, microvascular and ischemic miocadiopathy have been suspected. We describe a consecutive series of 50 patients (43 males, 7 women) with HIV infection and severe immunodepression (CD4<200/ml) that had clinical, ECG and echocardiographic evaluation. There were 24 drug addicted patients, 17 homosexual patients, and 10 heterosexuals. Some of these patients had the following opportunistic infections: tuberculosis (n=20), Pneumocystis carinii (n=9), Criptocococis (n=9), oropharyngeal candidosis (n=5), toxoplasmosis (n=5), histoplasmosis (n=1) and Kaposi’s sarcoma (n=2). After clinical evaluation 15/50 patients had some kind of cardiovascular complication: 6 patients had congestive heart failure, 5 patients presented with pericardial effusion, one patient has a reversible cardiac arrest, and one patient had pulmonary valvular endocarditis. After Doppler echocardiographic evaluation (according to the American echocardiography association), we found 20 patients with left ventricular diastolic dysfunction, 9 patients with right ventricular diastolic dysfunction and 6 patients with left ventricular systolic dysfunction. In conclusion, our series found left diastolic dysfunction in nearly 40 % of cases and cardiavasular events (pericarditis, heart congestive failure, arrhythmias) in 26% of cases. Cardiovascular complications have prognostic implications in AIDS and shoul be early detected. Further pathological and immunohistochemical studies are needed to clarify the phyiopathological etiologies in AIDS miocardiopathy. [less ▲]

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See detailDecrease in systemic tolerance to fed ovalbumin in indomethacin-treated mice.
Louis, Edouard ULg; Franchimont, D.; Deprez, Manuel ULg et al

in International Archives of Allergy & Immunology (1996), 109(1), 21-6

The oral administration of non-steroidal anti-inflammatory drugs (NSAID) to animals induces a quick increase in intestinal permeability and secondary inflammatory lesions of the intestine. The mechanisms ... [more ▼]

The oral administration of non-steroidal anti-inflammatory drugs (NSAID) to animals induces a quick increase in intestinal permeability and secondary inflammatory lesions of the intestine. The mechanisms leading to the inflammatory lesions are hypothetical. The increased intestinal permeability could allow a greater mucosal and systemic penetration of fed antigens and bacterial products leading to an abnormal mucosal and systemic immune and inflammatory response toward these materials. We examined the effect of oral dosing with indomethacin on ovalbumin serum levels and the systemic immune response to ovalbumin in mice fed with ovalbumin. The ovalbumin serum level was higher in indomethacin-treated mice and the increase was proportional to the dose of indomethacin. It was associated with epithelial and subepithelial lesions. Moreover, the systemic humoral and, to a lesser extent, the cellular tolerance were partially abrogated in the treated mice. These findings suggest that the oral administration of indomethacin in mice induces an increased passage of fed antigen through the intestinal epithelium associated with a decrease in systemic tolerance to this antigen. The reason for this decrease remains unclear. Besides a disequilibrium between systemic and mucosal immune responses, a loss of integrity of the intestinal epithelial cells and a direct immunomodulating effect of indomethacin may also be involved. This decrease in systemic tolerance to luminal antigen could be involved in the development of NSAID enteropathy. [less ▲]

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See detailThe effects of dietary crude protein on growth of the Eurasian perch Perca fluviatilis
Fiogbe, E. D.; Kestemont, P.; Mélard, Charles ULg et al

in Aquaculture (1996)

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See detailChanges in gene expression in the leaf of Lolium temulentum L. Ceres during the photoperiodic induction of flowering
Périlleux, Claire ULg; Ongena, Philippe; Bernier, Georges ULg

in Planta (1996), 200(1), 32-40

Unifoliated plants of Lolium temulentum L. Ceres were induced to flower by a unique 24-h long day (LD) consisting of the extension of the regular 8-h short day (SD) (400 µmol photons·m-2·s-1, fluorescence ... [more ▼]

Unifoliated plants of Lolium temulentum L. Ceres were induced to flower by a unique 24-h long day (LD) consisting of the extension of the regular 8-h short day (SD) (400 µmol photons·m-2·s-1, fluorescence + incandescence) with incandescence at 10–15 µmol photonsm -2·s-1. The polyadenylated-RNA complement of leaf blade tissues was analysed at 4-h intervals during the photoperiod extension in LD vs. SD, by using two-dimensional polyacrylamide gel electrophoresis to resolve in-vitro-translated products. Of the 991 spots that were analysed, none appeared or disappeared during the inductive cycle, i.e. no qualitative effect of floral induction was detected, at any time. Sixty-eight spots were found whose intensity was influenced by lengthening of the photoperiod; 50 of them, i.e. ca. 5 of the population analysed, were affected before the end of the extension period and were thus potentially related to floral induction. Many of these RNAs were not quantitatively constant during a 24-h cycle in SD. Seven of them oscillated according to the ‘light-on’ and the ‘light-off’ signals, among which three seemed to be controlled by phytochrome since their relative amount increased under the standard light conditions but decreased under incandescence even faster than in darkness. The large majority of other RNAs varied with a timing that was not clearly driven by the alternation of light and darkness, indicating that genes related to the biological clock may be especially sensitive to the lengthening of the photoperiod. Furthermore, seven spots were observed that underwent a phase-shift in LD, which consisted, for six of them, of a phase advance of 4–8 h. The steady-state level of CAB mRNA was analysed because the CAB gene family (encoding the chlorophyll a/b-binding proteins of the light-harvesting complexes) is known to be controlled both by the biological clock and phytochrome. In SD, the level was high in the light and low in darkness; the fluctuation was conducted by a circadian rhythm. When plants were exposed to the inductive LD, the peak of mRNA accumulation that was expected according to the endogenous rhythmicity was abolished, possibly because of the change in light quality during the LD extension. [less ▲]

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