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See detailQSO mass constraints from gravitational lensing studies of quasar pairs. The cases of Q1548+114 A & B and Q1148+0055 A & B
Claeskens, Jean-François ULg; Lee, D.-W.; Remy, M. et al

in Astronomy and Astrophysics (2000), 356

New constraints on the mass of quasars are derived from gravitational lensing studies of the QSO pairs Q1548+114 A & B and Q1148+0055 A & B, for which new ground-based and Hubble Space Telescope (HST ... [more ▼]

New constraints on the mass of quasars are derived from gravitational lensing studies of the QSO pairs Q1548+114 A & B and Q1148+0055 A & B, for which new ground-based and Hubble Space Telescope (HST) direct imagery have been obtained. In the case of Q1548+114 A & B, QSO A has been resolved into its host galaxy and a close companion. The non-detection with HST of a secondary lensed image of the background QSO in the close vicinity of the foreground one and the modeling of the host of QSO A, of the companion and of field galaxies with Singular Isothermal Spheres (SIS) yield a robust upper limit on the central compact mass of 4.5 10[SUP]11[/SUP] M[SUB]sun[/SUB]. On the other hand, the combined mass of Q1148+0055 B plus host must be smaller than 6.5 10[SUP]11[/SUP] M[SUB]sun[/SUB] since no secondary lensed image has been detected with HST. Photometry and relative astrometry of all the detected objects are reported. Based on data collected with the Hubble Space Telescope and at the European Southern Observatory, La Silla, Chile [less ▲]

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See detailNeurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin.
Bouilleret, V.; Schwaller, B.; Schurmans, Stéphane ULg et al

in Neuroscience (2000), 97(1), 47-58

The functional role of the calcium-binding proteins parvalbumin, calretinin, and calbindin D-28k for epileptogenesis and long-term seizure-related alterations of the hippocampal formation was assessed in ... [more ▼]

The functional role of the calcium-binding proteins parvalbumin, calretinin, and calbindin D-28k for epileptogenesis and long-term seizure-related alterations of the hippocampal formation was assessed in single- and double-knockout mice, using a kainate model of mesial temporal lobe epilepsy. The effects of a unilateral intrahippocampal injection of kainic acid were assessed at one day, 30 days, and four months post-injection, using various markers of GABAergic interneurons (GABA-transporter type 1, GABA(A)-receptor alpha1 subunit, calretinin, calbindin D-28k, somatostatin, and neuropeptide Y). Parvalbumin-deficient, parvalbumin/calbindin-deficient, and parvalbumin/calretinin-deficient mice exhibited no difference in cytoarchitecture of the hippocampal formation and in the number, distribution, or morphology of interneurons compared to wild-type mice. Likewise, mutant mice were not more vulnerable to acute kainate-induced excitotoxicity or to long-term effects of recurrent focal seizures, and exhibited the same pattern of neurochemical alterations (e.g., bilateral induction of neuropeptide Y in granule cells) and morphogenic changes (enlargement and dispersion of dentate gyrus granule cells) as wild-type animals. Quantification of interneurons revealed no significant difference in neuronal vulnerability among the genotypes.These results indicate that the calcium-binding proteins investigated here are not essential for determining the neurochemical phenotype of interneurons. Furthermore, they are not protective against kainate-induced excitotoxicity in this model, and do not appear to modulate the overall level of excitability of the hippocampus. Finally, seizure-induced changes in gene expression in granule cells, which normally express high levels of calcium-binding proteins, apparently were not affected by the gene deletions analysed [less ▲]

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See detailEffet de l’ammoniac sur la fibre C impliquée dans le réflexe de la toux chez le porc
Moreaux, B.; Nemmar, R.; Gustin, Pascal ULg

in Journées de la Recherche Porcine en France (2000), 32

The effect of ammonia on the C-fibre which is involved in the citric acid induced coughing reflex was assessed. The piglets were exposed during a period of 24 hours or 4 days to a concentration of 15 or ... [more ▼]

The effect of ammonia on the C-fibre which is involved in the citric acid induced coughing reflex was assessed. The piglets were exposed during a period of 24 hours or 4 days to a concentration of 15 or 30 ppm ammonia in an inhalation chamber . During this challenge, the animais underwent cough induction tests at two days intervals. Another group was exposed to ammonia (30 ppm) for 48 hours, after this period, substance P was assayed in liquids collected from broncho-alvealor and tracheal washings (BAL and TAL) and in tracheal and airway mucosa . Ammonia (30 ppm) induced an inhibition 0f the coughing reflex in pigs. The minimum period of exposure necessary to provoke this effect was 48 hours. The same ammonia concentration aiso induced o significant increase in substance P concentrations in BAL and TAL and a significant decrease in concentrations of the tracheal mucosa. We conclude that ammonia at o concentration of 30 ppm inhibits the citric acid induced coughing reflex. The effect was partly mediated by the release of substance P from the C-fibre. [less ▲]

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See detailMass-murder deletion of 19 Orfs from Saccharomyces cerevisiae chromosome XI
Vandenbol, Micheline ULg; Fairhead, C.

in Gene (2000), 247(1-2),

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See detailLa rédaction cartographique des spatiocartes
Donnay, Jean-Paul ULg; Cornélis, Bernard

in Bulletin de la Société Géographique de Liège (2000), 38

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See detailInfectious Agents Associated with Rabbit Pneumonia: Isolation of Amyxomatous Myxoma Virus Strains
Marlier, Didier ULg; Mainil, Jacques ULg; Linden, Annick ULg et al

in Veterinary Journal (2000), 159(2), 171-8

Sixty-six rabbits, with no history of vaccination against myxomatosis and which had died of pulmonary lesions, were submitted for virological and serological tests for Myxoma virus (MV) infection and for ... [more ▼]

Sixty-six rabbits, with no history of vaccination against myxomatosis and which had died of pulmonary lesions, were submitted for virological and serological tests for Myxoma virus (MV) infection and for bacteriological examinations. At post mortem, the diagnoses based on observed lesions were as follows: acute haemorrhagic pneumonia (38%); acute suppurative bronchopneumonia (35%); and fibrinohaemorrhagic bronchopneumonia with fibrinous pleuritis (27%). MV was isolated from 10% of the rabbits, mainly from those with acute haemorrhagic pneumonia. Serological evidence of MV infection was demonstrated in 44% of rabbits. Pathogenic bacteria species isolated from lungs were Pasteurella (spp. and multocida), Escherichia coli, Bordetella bronchiseptica and Pseudomonas aeruginosa, respectively, from 41, 11, 7 and 6% of samples. No relationship could be established between the presence of specific antibodies to MV and the observed pulmonary lesions or the results of the bacteriological examinations. A significant trend was established between the severity of the lesions and the results of the bacteriological examinations. [less ▲]

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See detailIntégration du transfert de rugosité à un modèle de laminage à froid
Collette, Caroline; Counhaye, Christian; Ponthot, Jean-Philippe ULg

in Revue de Métallurgie [=Revue de Métallurgie. Cahiers d'Informations Techniques] (2000)

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See detailTissue distribution, autoradiography, and metabolism of 4-(2'-methoxyphenyl)-1-[2' -[N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethyl]piperazine (p-[(18)F]MPPF), a new serotonin 5-HT(1A) antagonist for positron emission tomography: An In vivo study in rats.
Plenevaux, Alain ULg; Weissmann, D.; Aerts, Joël ULg et al

in Journal of Neurochemistry (2000), 75(2), 803-11

The in vivo behavior of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-[(18)F]fluorobenzamido ]ethyl]-piperazine (p-[(18)F]MPPF), a new serotonin 5-HT(1A) antagonist, was studied in awake, freely moving ... [more ▼]

The in vivo behavior of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-[(18)F]fluorobenzamido ]ethyl]-piperazine (p-[(18)F]MPPF), a new serotonin 5-HT(1A) antagonist, was studied in awake, freely moving rats. Biodistribution studies showed that the carbon-fluorine bond was stable in vivo, that this compound was able to cross the blood-brain barrier, and that a general diffusion equilibrium could account for the availability of the tracer. The great quantity of highly polar metabolites found in plasma did not contribute to the small amounts of metabolites found in hippocampus, frontal cortex, and cerebellum. Exvivo p-[(18)F]MPPF and in vitro 8-hydroxy-2-(di-n-[(3)H]propylamino)tetralin autoradiography were compared both qualitatively and quantitatively. Qualitative evaluation proved that the same brain regions were labeled and that the p-[(18)F]MPPF labeling is (a) in total agreement with the known distribution of 5-HT(1A) receptors in rats and (b) characterized by very low nonspecific binding. Quantitative comparison demonstrated that the in vivo labeling pattern obtained with p-[(18)F]MPPF cannot be explained by differences in regional blood flow, capillary density, or permeability. The 5-HT(1A) specificity of p-[(18)F]MPPF and binding reversibility were confirmed in vivo with displacement experiments. Thus, this compound can be used to evaluate parameters characterizing 5-HT(1A) binding sites in the brain. [less ▲]

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See detailLa douleur pelvienne chez le patient oncologique
Jansen, Nicolas ULg; Nickers, Philippe ULg; Devoghel, Jean-Claude ULg

in Oncologie (2000), 2(4), 187-200

Pelvic pain is a common problem in the general population. In cancer patients this pain can be secondary to tumor activity or recent tumor related interventions (surgery, radiotherapy, chemotherapy). On ... [more ▼]

Pelvic pain is a common problem in the general population. In cancer patients this pain can be secondary to tumor activity or recent tumor related interventions (surgery, radiotherapy, chemotherapy). On the other hand cancer patients can also suffer from not cancer related pain. Cancer related pain is often chronic. Whatever the cause of this pain, an important psychological factor is often present, if not attributing to the pathogenesis of the pain, then as an secondary effect from the pain. Managing pelvic pain requires knowledge of the regional anatomy. A general overview is given of the approach to an oncological patient presenting with pelvic pain. Three different possibilities are discussed: (1) pain in a patient without a presently known pelvic or abdominal malignancy, (2) pain in a patient treated recently for a tumor in the pelvic area or lower abdomen, (3) pain in an so far untreated patient with a known tumor. Finally an overview of treatment options is presented. [less ▲]

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See detailInvolvement of acyl coenzyme A oxidase isozymes in biotransformation of methyl ricinoleate into γ-decalactone by Yarrowia lipolytica
Waché, Y.; Laroche, C.; Bergmark, K. et al

in Applied and Environmental Microbiology (2000), 66(3), 1233-1236

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes ... [more ▼]

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes (POX1 through POX5) (H. Wang et al., J. Bacteriol. 181:5140-5148, 1999). Here, these mutants were studied for lactone production. Monodisrupted strains produced similar levels of lactone as the wild-type strain (50 mg/liter) except for Δpox3, which produced 220 mg of γ-decalactone per liter after 24 h. The Δpox2 Δpox3 double-disrupted strain, although slightly affected in growth, produced about 150 mg of lactone per liter, indicating that Aox2p was not essential for the biotransformation. The Δpox2 Δpox3 Δpox5 triple- disrupted strain produced and consumed lactone very slowly. On the contrary, the Δpox2 Δpox3 Δpox4 Δpox5 multidisrupted strain did not grow or biotransform methyl ricinoleate into γ-decalactone, demonstrating that Aox4p is essential for the biotransformation. [less ▲]

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See detailCaractéristiques spermatiques des taureaux de race Borgou au Bénin
Adamou N'Diaye, M.; Gbangboche, A.B.; Adjovi, A. et al

in Annales des Sciences Agronomiques du Bénin (2000), 2

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See detailVitamines anti-oxydantes dans la prevention des maladies cardio-vasculaires. 2eme partie: le point sur les essais cliniques.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(2), 105-9

Various epidemiological studies suggested that individuals with high intake of antioxidant vitamins (E, A and C) have a better cardiovascular prognosis than subjects with relative deficiencies in such ... [more ▼]

Various epidemiological studies suggested that individuals with high intake of antioxidant vitamins (E, A and C) have a better cardiovascular prognosis than subjects with relative deficiencies in such vitamins. However, placebo-controlled randomized clinical trials did not demonstrate that a specific supplementation in either alpha-tocopherol (vitamin E) or beta-carotene (vitamin A) allows to reduce the incidence of major cardiovascular events, in the general population or even in various subgroups at high risk, and there is no such controlled trials with vitamin C alone. Some studies suggested that combined supplements of several antioxidant vitamins might be more efficacious, and these observations led to initiate several large controlled studies. Thus, until now, there is no convincing arguments in the literature in favour of artificial supplements of antioxidant vitamins. It seems preferable to encourage a well-balanced healthy diet while awaiting the results of the large prospective ongoing trials with combined supplementation. [less ▲]

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See detailTheoretical analysis of a dynamic thermoconvective pattern in a circular container
Dauby, Pierre ULg; Colinet, Pierre; Johnson, Duane

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (2000), 61(3), 2663-2668

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See detailTubal versus uterine placentation: similar HLA-G expressing extravillous cytotrophoblast invasion but different maternal leukocyte recruitment
Proll, J.; Bensussan, A.; Goffin, Frédéric ULg et al

in Tissue Antigens (2000), 56(6), 479-491

The nonclassical HLA-G class I gene is expressed by extravillous cytotrophoblast that invades decidua in uterine pregnancy, suggesting that it may contribute to the immunological mechanisms that protect ... [more ▼]

The nonclassical HLA-G class I gene is expressed by extravillous cytotrophoblast that invades decidua in uterine pregnancy, suggesting that it may contribute to the immunological mechanisms that protect the fetus against maternal alloimmune response and/or pathogen infections. We first addressed the question of whether HLA-G expression was dependent on maternal tissue environment by comparing uterine and ectopic tubal pregnancies. Using HLA-G-specific mAb on placental cryosections, we found by immunohistochemistry that all subtypes of extravillous cytotrophoblast similarly expressed HLA-G in pregnant tubes, demonstrating that its expression was independent of the site of implantation. We next compared by immunohistochemistry the phenotype of maternal leukocytes recruited in both pregnant tissues. In contrast to decidua, pregnant tubes were characterized firstly, by the lack of natural killer (NK) cells and of cells expressing CD94 receptor specific for HLA-E, secondly, by a prominent increase of CD8+ T cells, dendritic cells, and macrophages, the latter co-expressing the LIR1/ILT2 killer immunoglobulin-like receptor (KIR), and finally, by the presence of cells expressing LIR2/ILT4 KIR or BY55 NK receptors, known to bind to HLA-G. Such cell types may favor a unique innate defense in pregnant tubes. These observations also suggest that trophoblast HLA-G expression does not influence the recruitment of particular maternal leukocytes in pregnant tissues. [less ▲]

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See detailQuantitative bacterial cultures and cytological examination of bronchoalveolar lavage specimens in the diagnosis of lower respiratory tract disease in dogs: a retrospective study of 48 cases.
Peeters, Dominique ULg; McKierman, B.; Weisiger, R. et al

in Journal of Veterinary Internal Medicine (2000), 14(5), 534-541

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective ... [more ▼]

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective study was conducted to determine the usefulness of quantitative aerobic cultures and Gram stain intracellular bacteria counts from bronchoalveolar lavage (BAL) specimens in dogs in diagnosing lower respiratory tract infection (LRTI) and to determine whether chronic bronchitis is associated with marked bacterial growth in dogs. The threshold determined to define clinically relevant bacterial growth was 1.7 x 10(3) colony-forming units per milliliter of BAL fluid. We used this threshold and found that diagnostic sensitivity and specificity were 86% and 100%, respectively. With a threshold for infection of >2 intracellular bacteria observed in any of 50 fields, microscopic examination of Gram stain BAL preparations had a sensitivity of 71% and a specificity of 97% in establishing LRTI. There was a high correlation between bacterial morphology on BAL Gram stain and bacterial cultures. Combining the results of intracellular bacteria counts from the BAL Gram stain with those from the quantitative cultures, the sensitivity in diagnosing LRTI was 87% and the specificity was 97%. BAL quantitative cultures as well as quantitating intracellular bacteria on Gram stain BAL cytology were revealed to be useful in identifying LRTI in dogs. Chronic bronchitis does not appear to be associated with marked bacterial growth in dogs. [less ▲]

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See detailComments on the criticisms of Coquel and Abdesselam-Rouighi (1999) to the paper of Loboziak et al. (1998)
Loboziak, S; Melo; Streel, Maurice ULg

in Annales de la Société Géologique du Nord (2000), 8

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See detailThe internet: A global telecommunications solution?
Mathy, Laurent ULg; Edwards, C.; Hutchison, D.

in IEEE Network (2000), 14(4), 46--57

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See detailNeoteny and progenesis as two heterochronic processes involved in paedomorphosis in Triturus alpestris (Amphibia: Caudata)
Denoël, Mathieu ULg; Joly, Pierre

in Proceedings of the Royal Society B : Biological Sciences (2000), 267(1451), 1481-1485

Current theories on the evolution of paedomorphosis suppose that several ontogenetic pathways have appeared according to different selective pressures. The aim of this study was to find out whether two ... [more ▼]

Current theories on the evolution of paedomorphosis suppose that several ontogenetic pathways have appeared according to different selective pressures. The aim of this study was to find out whether two distinct processes can lead to paedomorphosis in the Alpine newt, Triturus alpestris. In this respect, we compared age structures of paedomorphic and metamorphic individuals in two newt populations where the two forms lived syntopically. Whereas paedomorphosis resulted in a slower rate of somatic development in one population, it resulted in an acceleration of sexual maturation in the other population. These processes correspond to neoteny and progenesis, respectively. These results suggest that phenotypic plasticity can result from contrasted ontogenetic pathways between two populations of the same species. They give support to models that consider gonadic development as the target of selection under different environmental pressures. [less ▲]

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See detailAutomatisation d'un banc de répartition pour buses de pulvérisation
Lebeau, Frédéric ULg; Hamza, Elies; Destain, Marie-France ULg

in Cahiers Agricultures (2000)

Les bancs de répartition constituent l'élement de base permettant de tester la sensibilité de la distribution transversale des buses de pulvérisation aux différents paramètres de fonctionnement. L'article ... [more ▼]

Les bancs de répartition constituent l'élement de base permettant de tester la sensibilité de la distribution transversale des buses de pulvérisation aux différents paramètres de fonctionnement. L'article présente un banc d'essai conforme à la norme ISO 5682/1 qui permet une lecture automatisée des différentes grandeurs (pression, débit, volume recueilli). [less ▲]

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See detailComment je traite.... De la pharmacologie speciale a la therapeutique medicale: plaidoyer pour un enseignement privilegiant l'apprentissage au raisonnement therapeutique, de la decision a la prescription.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 811-6

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important ... [more ▼]

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important step of the medical approach. Such a learning should occur progressively throughout the medical education, focusing, first, on the therapeutic reasoning ("why?") and, second, on the practical application leading to the prescription ("how?"). The medical student should learn the difficult task of integrating disease, drug and patient, in order to optimize the benefit/risk ratio, while being informed about new concepts such as "Evidence-Based Medicine" and pharmacoeconomics. [less ▲]

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See detailNon-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss.
Luyckx, Françoise ULg; Lefebvre, Pierre ULg; Scheen, André ULg

in Diabètes & Métabolism (2000), 26(2), 98-106

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance, and is now considered as one of the commonest liver diseases in western countries. It is frequently associated with ... [more ▼]

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance, and is now considered as one of the commonest liver diseases in western countries. It is frequently associated with severe obesity, especially abdominal adiposity, and is intimately related to various clinical and biological markers of the insulin resistance syndrome. Especially, both the prevalence and the severity of liver steatosis are related to male sex, body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. A substantial weight loss following gastroplasty is accompanied by a marked reduction in the prevalence and the severity of the various biological abnormalities of the metabolic syndrome and, concomitantly, by an important regression of liver steatosis in most obese patients. However, in some patients, this rapid and drastic weight loss may result in a mild increase in inflammatory lesions (hepatitis), despite the regression of steatosis, which might result from the rapid mobilization of fatty acids or cytokines from adipose tissue, especially visceral fat. The intimate relationship between NASH and obesity leads to the concept that NASH may be considered as another disease of affluence, as is the insulin resistance syndrome and perhaps being part of it. [less ▲]

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See detailAlternative area-perimeter ratios for measurement of 2-D shape compactness of habitats.
Bogaert, Jan ULg; Rousseau, R; Van Hecke, P et al

in Applied Mathematics and Computation (2000), 111(1), 71-85

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See detailOppositions locales et dynamiques d'environnementalisation
Mormont, Marc ULg; Bertrand, Anne

in Espaces et Sociétés (Paris, France) (2000), (101-102), 93-112

Local conflicts provoke collective action that through new coalitions induce reformulations of the problems and elarge scope and scaling of environmental problems. These processes are called ecologization ... [more ▼]

Local conflicts provoke collective action that through new coalitions induce reformulations of the problems and elarge scope and scaling of environmental problems. These processes are called ecologization dynamics and are going to transform environmental politics. [less ▲]

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See detailEfficiency measurement, multiple-output technologies and distance functions: with application to European Railways
Coelli, Tim; Perelman, Sergio ULg

in Applied Economics (2000), (32), 1967-1976

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in ... [more ▼]

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in a multiple-output industry using econometric methods one would usually either: (a) aggregate outputs into a single index of output (e.g., total revenue or a multilateral Tornqvist output index); or (b) attempt to model the technology using a dual cost function. The first of these methods require that output prices be observable (and reflect revenue maximising behaviour), while the latter approach requires an assumption of cost-minimising behaviour. There are a number of instances, however, when neither of these requirements are met (the public sector contains many examples). In this study we outline the recently developed distance function solution to the multi-output problem. The method is illustrated using data on European railways. Output-orientated, input-orientated and constant returns to scale distance functions are estimated using corrected ordinary least squares. The distance function estimates are also compared with production function estimates involving aggregate output measures. These comparisons indicate that, for the case of European railways, a production function involving a multilateral Tornqvist output index exhibits substantially less aggregation bias relative to a production function that uses total revenue as a measure of aggregate output. [less ▲]

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See detailErythropoiesis and renal transplant pregnancy.
Magee, L. A.; von Dadelszen, P.; Darley, J. et al

in Clinical Transplantation (2000), 14(2), 127-35

OBJECTIVE: To examine erythropoiesis in renal transplant pregnancies. METHODS: Retrospective cohort study of 30 renal transplant cases and 30 age, smoking and parity-matched healthy controls with normal ... [more ▼]

OBJECTIVE: To examine erythropoiesis in renal transplant pregnancies. METHODS: Retrospective cohort study of 30 renal transplant cases and 30 age, smoking and parity-matched healthy controls with normal index pregnancy. Retrospective chart review and assay of frozen antenatal serum (for serum erythropoietin concentration [serum EPO]), transferrin receptor protein [TfR], ferritin, folate and B12) were performed. The linear regression equation for normal pregnancy controls was used to calculate predicted [serum EPO] and the observed/predicted (O/P) log [serum EPO] was plotted. The relationship between [serum EPO] and haemoglobin (Hb) among transplant cases was considered to be different from that among controls if the slope of the O/P log [serum EPO] versus Hb regression was significantly different from zero. RESULTS: The transplant (14 cadaveric) to conception interval was (median [range]) 33.5 [4, 189] months. Immunosuppressants were azathioprine (n = 25), cyclosporine (n = 22) and/or prednisone (n = 25). Cases were more often primiparous (20 vs. 7 [controls]; p = 0.01), had pre-existent hypertension (20 vs. 0 [controls]; p < 0.001), developed new/increased hypertension or pre-eclampsia (28 vs. 0 [controls]; p < 0.001) and an antenatal rise in creatinine (14 vs. 2 [controls]; p < 0.001). In early pregnancy, cases had similar EPO (15.2 [2.6, 84.6] vs. 15.7 [6.4, 41.0] [controls] U/L) but lower Hb (101 [65, 129] vs. 116 [106, 150] g/L; p < 0.001). Twenty-two (73%) cases had Hb < 100 g/L (vs. 4 [controls]; p < 0.0001); Hb was comparable at 6 wk postpartum. With advancing gestational age (GA), Hb remained stable and serum EPO increased in both groups. The slope of the O/P log [serum EPO] versus Hb for transplant cases was significantly different from zero within both the 17-28 wk (slope +/- SEM: 0.010 +/- 0.002; p < 0.0001) and the 29-42 wk GA categories (0.006 +/- 0.003; p = 0.02). Cases showed smaller rises in serum TfR (change 481 [- 1471, 2780]) vs. 1119 [- 698, 4195] [controls] ng/mL; p = 0.005). CONCLUSIONS: Anaemia frequently complicates renal transplant pregnancies, in which serum EPO is inappropriately low and the rate of erythropoiesis blunted. [less ▲]

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See detailAcute pancreatitis attributed to the use of interferon alfa-2b
Eland, I. A.; Rasch, M. C.; Sturkenboom, M. J. et al

in Gastroenterology (2000), 119(1), 230-233

Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection. The first patient was a 40-year-old man ... [more ▼]

Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection. The first patient was a 40-year-old man who developed acute pancreatitis after 15 weeks of treatment with 3 MU IFN-alpha subcutaneously (SC) 3 times weekly and 1200 mg ribavirin. After disappearance of symptoms and normalization of laboratory values, oral intake of solid foods and IFN-alpha therapy were restarted. Within hours, a relapse of acute pancreatitis occurred. A rechallenge with IFN-alpha 4 days later was followed by a prompt increase in serum lipase level, and IFN-alpha therapy was discontinued. The second patient was a 38-year-old man who developed acute pancreatitis 2 hours after SC administration of 5 MU IFN-alpha. Ultrasound endoscopy showed sludge in the gallbladder. The patient was rechallenged 5 weeks later with 3 MU IFN-alpha SC. Although serum amylase and lipase levels increased after readministration of IFN-alpha, treatment was continued. The patient was readmitted 2 weeks later with severe abdominal pain, and IFN-alpha administration was discontinued. Considering the temporal relationship between the start of IFN-alpha treatment and development of acute pancreatitis, the absence of other clear etiologic factors for acute pancreatitis, disappearance of symptoms after discontinuation of IFN-alpha, and positive reactions to rechallenge, IFN-alpha is the most probable cause for development of acute pancreatitis in these patients. [less ▲]

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See detailRecommandations pour le traitement de l'obesite.
Luyckx, Françoise ULg; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(5), 367-71

Obesity represents a major medical problem which is now considered more seriously from a scientific, clinical and economical point of view. Such an evolution was mandatory when considering the usual ... [more ▼]

Obesity represents a major medical problem which is now considered more seriously from a scientific, clinical and economical point of view. Such an evolution was mandatory when considering the usual contempt for what is now considered as a chronic disease and especially the charlatanism which was observed among medical and non-medical spheres. Hence, as for numerous other pathologies, international guidelines have recently been published to optimize the management of obesity, from the view point of efficacy and, more particularly, safety. We will summarize the main recommendations as far as diet and physical treatment, pharmacotherapy and bariatric surgery are concerned. Finally, we will briefly describe general guidelines on the management of obese subjects taking into account the degree of weight excess and the presence of complications. [less ▲]

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See detailLa prescription de l'action publique
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2000)

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See detailNotions de base de physiologie de l'effort
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

In general, muscular exertion occurs when there is oxygenation of the energy substrates carbon hydrate and fatty acids. At the beginning of exercise and/or when there is extra exertion, anaerobic ... [more ▼]

In general, muscular exertion occurs when there is oxygenation of the energy substrates carbon hydrate and fatty acids. At the beginning of exercise and/or when there is extra exertion, anaerobic metabolism also participates in the synthesis of ATP, which is essential for muscular contraction. The organism's oxygen consumption is proportional to the intensity of the effort, except during anaerobic metabolism. The maximum quantity of substrates that can oxygenate the muscles per unit time depends on the enzymatic material available. When the total aerobic capacity is used, the oxygen consumption is said to be maximal. The oxygen consumed at cellular level is taken from the ambient air at the areas of pulmonary exchange and transported throughout the body by the cardiovascular system. It is therefore essential that there is sufficient functional ability to adapt to cardiovascular and respiratory changes in order to ensure adequate O2 and nutrient transport and evacuation of CO2 and heat. The two systems adapt with exercise and training [less ▲]

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See detailForest canopy perforation in time and space in Amazonian Ecuador.
Salvador-Van Eysenrode, D; Bogaert, Jan ULg; Van Hecke, P et al

in Acta Oecologica: International Journal of Ecology (2000), 21(4-5), 285-291

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See detailClinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantation.
Baron, Frédéric ULg; Gothot, André ULg; Salmon, Jean ULg et al

in British Journal of Haematology (2000), 111(3), 745-53

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome ... [more ▼]

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome, termed autologous GVHD has notable anti-tumour activity in animal studies. We intended to induce autologous GVHD with CyA in patients undergoing an autologous HSCT. We prospectively studied 118 patients with miscellaneous malignancies undergoing an autologous HSCT with low-dose CyA to characterize the clinical syndrome, its frequency and clinical course, and to determine the factors affecting its incidence. Patients received CyA from d -1 through to d 28, first starting at 2 mg/kg intravenously and then orally as soon as feasible. The dose was adjusted to achieve pre-dose blood levels around 100 ng/ml. A skin biopsy was performed when a skin rash was observed. Thirty-three percent of the patients developed clinical GVHD: clinical stage 1 in 21 patients, stage 2 in seven patients, and stage 3 in three patients. Although total body irradiation (TBI) or high-dose cyclophosphamide were previously thought to be needed, autologous GVHD occurred in five out of 12 patients (42%) after a preparative regimen with high-dose melphalan alone. Autologous GVHD was significantly more frequent in patients older than 33 years, in patients who had received high doses of granulocyte-macrophage colony forming units (CFU-GM) and in those with a diagnosis of myeloid malignancy, compared with those with lymphoid malignancies or solid tumours. A significant negative association was also found with HLA-DR6. In lymphoma patients, GVHD occurred more frequently in advanced disease than in first or second complete remission (CR1-2) patients. All other factors studied were not predictive for GVHD. In conclusion, CyA-induced GVHD is reproducibly and safely induced with doses of CyA adapted to achieve blood levels around 100 ng/ml. In retrospective analysis, there was no survival advantage for patients with GVHD. Phase III trials with this approach are needed to evaluate its anti-tumoral effect. [less ▲]

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See detailHépatites C sporadiques. Risque iatrogène non négligeable
Delwaide, Jean ULg

in Interface (2000), 6

On estime à plus de 150 millions le nombre d'individus infectés par le virus de l'hépatite C dans le monde. En Belgique, cette prévalence est estimée à 10/0, et la plupart des nouvelles contaminations se ... [more ▼]

On estime à plus de 150 millions le nombre d'individus infectés par le virus de l'hépatite C dans le monde. En Belgique, cette prévalence est estimée à 10/0, et la plupart des nouvelles contaminations se retrouvent chez les toxicomanes utilisant des drogues intraveineuses. Les transmissions en milieu hospitalier pourraient cependant rendre compte d'une part non négligeable des hépatites C dites «sporadiques», dont le mode de transmission n'est jusqu'ici pas élucidé. [less ▲]

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See detailWandeinfluss auf die Sedimentationsgeschwindigkeit von Kugeln
Henschke, M; Waheed, A; Pfennig, Andreas ULg

in Chemie Ingenieur Technik (2000), 72(11), 1376-1380

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See detailPerformance of Belgian general practitioners: a "best practice approach based on patient level data"
Fecher-Bourgeois, Fabienne ULg; Gillet, Pierre ULg

in Cahiers Economiques de Bruxelles (2000), 167(3ème trimestre 2000), 381-396

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See detailEpithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice.
Lemaire-Vieille, C.; Schulze, T.; Podevin-Dimster, V. et al

in Proceedings of the National Academy of Sciences of the United States of America (2000), 97(10), 5422-7

The expression of the cellular form of the prion protein (PrP(c)) gene is required for prion replication and neuroinvasion in transmissible spongiform encephalopathies. The identification of the cell ... [more ▼]

The expression of the cellular form of the prion protein (PrP(c)) gene is required for prion replication and neuroinvasion in transmissible spongiform encephalopathies. The identification of the cell types expressing PrP(c) is necessary to understanding how the agent replicates and spreads from peripheral sites to the central nervous system. To determine the nature of the cell types expressing PrP(c), a green fluorescent protein reporter gene was expressed in transgenic mice under the control of 6.9 kb of the bovine PrP gene regulatory sequences. It was shown that the bovine PrP gene is expressed as two populations of mRNA differing by alternative splicing of one 115-bp 5' untranslated exon in 17 different bovine tissues. The analysis of transgenic mice showed reporter gene expression in some cells that have been identified as expressing PrP, such as cerebellar Purkinje cells, lymphocytes, and keratinocytes. In addition, expression of green fluorescent protein was observed in the plexus of the enteric nervous system and in a restricted subset of cells not yet clearly identified as expressing PrP: the epithelial cells of the thymic medullary and the endothelial cells of both the mucosal capillaries of the intestine and the renal capillaries. These data provide valuable information on the distribution of PrP(c) at the cellular level and argue for roles of the epithelial and endothelial cells in the spread of infection from the periphery to the brain. Moreover, the transgenic mice described in this paper provide a model that will allow for the study of the transcriptional activity of the PrP gene promoter in response to scrapie infection. [less ▲]

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See detailERK activation upon hypoxia: involvement in HIF-1 activation.
Minet, E.; Arnould, T.; Michel, G. et al

in FEBS Letters (2000), 468(1), 53-8

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor activated by hypoxia. The HIF-1 activation transduction pathway is poorly understood. In this report, we investigated the activation of ... [more ▼]

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor activated by hypoxia. The HIF-1 activation transduction pathway is poorly understood. In this report, we investigated the activation of extracellular regulated kinases (ERK) in hypoxia and their involvement in HIF-1 activation. We demonstrated that in human microvascular endothelial cells-1 (HMEC-1), ERK kinases are activated during hypoxia. Using dominant negative mutants, we showed that ERK1 is needed for hypoxia-induced HIF-1 transactivation activity. Moreover, using a kinase assay and Western blot experiments, we showed that HIF-1alpha is phosphorylated in hypoxia by an ERK-dependent pathway. These results evidence the role of mitogen-activated protein kinase in the transcriptional response to hypoxia. [less ▲]

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See detailLa place de l'intervention de Ross (autogreffe pulmonaire) dans la chirurgie de la valve aortique
RADERMECKER, Marc ULg; GRENADE, Thierry ULg; Gach, J. et al

in Revue Médicale de Liège (2000), 55(1), 35-8

The pulmonary autograft operation consists of an aortic replacement using the autologous pulmonary valve. The pulmonary valve is substituted by a cryopreserved pulmonary homograft. This operation is in ... [more ▼]

The pulmonary autograft operation consists of an aortic replacement using the autologous pulmonary valve. The pulmonary valve is substituted by a cryopreserved pulmonary homograft. This operation is in fact a delicate double valve replacement whose benefits are linked to the viability of the new aortic substitute. The pulmonary autograft has superb hemodynamic features and very low thrombogenicity. The report of a selected observation offers the occasion of defining the current indications of this operation in aortic valve surgery. [less ▲]

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See detailVitamines anti-oxydantes dans la prevention des maladies cardio-vasculaires. 1ere partie: Le point sur les etudes epidemiologiques.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(1), 11-8

The hypothesis of the atherogenic role of oxidized. LDL lipoproteins and the observation of the longevity of individuals on a "mediterranean diet" led to the concept that antioxidant vitamins may exert ... [more ▼]

The hypothesis of the atherogenic role of oxidized. LDL lipoproteins and the observation of the longevity of individuals on a "mediterranean diet" led to the concept that antioxidant vitamins may exert cardiovascular protective effects. In this first article, we summarize the results of the main epidemiological studies which analyzed the influence of dietary intakes (or resulting plasma concentrations) in vitamin E (alpha-tocopherol), vitamin A (beta-carotene) or vitamin C (ascorbic acid). The three types of studies available in the literature provided quite heterogeneous results, in favour of a protective role of antioxidant vitamins as far as cross-cultural and most prospective observational studies were concerned, but rather negative when considering case-control studies. However, in general, epidemiological studies tended to support, a beneficial role of these antioxidant vitamins to prevent cardiovascular diseases, at least in some subgroups of individuals. [less ▲]

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See detailThe cognitive management of daily life activities in patients with mild to moderate Alzheimer's disease me in a day care centre : A case report
Adam, Stéphane ULg; Van der Linden, Martial ULg; Juillerat, Anne- Claude et al

in Neuropsychological Rehabilitation (2000), 10(5), 485-509

The day care centre appears to be a structure especially well suited for the management of mild to moderate Alzheimer patients. It constitutes a place in which performance in everyday life activities can ... [more ▼]

The day care centre appears to be a structure especially well suited for the management of mild to moderate Alzheimer patients. It constitutes a place in which performance in everyday life activities can be explored, and optimisation strategies can be installed before they are used at home. Another objective of the day care centre might also be to provide caregivers with support and ease the burden that the daily care of a demented patient represents. Finally, it may also help to alleviate the patient's loneliness. In this perspective, we describe the general organisation of the recently-created day care centre at the University Hospital of Liege. We also present the assessment and intervention programme which was conducted in this day care centre in order to reduce the generalised apathy and depressed mood observed in a 70-year-old Alzheimer patient (AM). This programme aimed at restoring a leisure activity (knitting) at home by proposing several adaptations designed to minimise the impact of AM's cognitive deficits on knitting activity. While an aggravation of her memory deficits was observed, the intervention significantly decreased AM's apathy and depressed mood as well as her husband's burden. [less ▲]

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See detailSignificance of random illite-vermiculite mixed layers in Pleistocene sediments of the northwestern Atlantic Ocean
Vanderaveroet, P.; Bout-Roumazeilles, V.; Fagel, Nathalie ULg et al

in Clay Minerals (2000), 35(4), 679-691

The clay mineralogy of Pleistocene sediments of eleven sediment cores at three ODP sites from 30 degrees N to 60 degrees N northwestern Atlantic Ocean has been investigated. The sediments are ... [more ▼]

The clay mineralogy of Pleistocene sediments of eleven sediment cores at three ODP sites from 30 degrees N to 60 degrees N northwestern Atlantic Ocean has been investigated. The sediments are characterized by the presence of random illite-vermiculite mixed layers (I-V) (up to 32% of the clay mineral assemblage). The I-V clays are much more abundant during interglacial periods than during glacial ones. They are attributed to detrital supply through erosion of high-latitude continental areas from which they are derived mainly from chemical weathering of micaceous phyllosilicates. Their spatial distribution and the specific conditions for their formation through weathering suggest that I-V mixed layers are mainly derived from the Canadian Shield. They were transported From their source to marine deposition areas by rivers, deep water masses or nepheloid layers. Due to the specific conditions required For the Formation of I-V, its occurrence and abundance are used as a palaeoclimate and palaeocirculation proxy for northwestern Atlantic Pleistocene sediment. [less ▲]

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See detailVapor-Liquid Equilibria in Quaternary Mixtures of Dimethyl Ether + n-Butane + Etha-nol + Water
Dahlhoff, Gerd; Pfennig, Andreas ULg; Hammer, Hartmut et al

in Journal of Chemical & Engineering Data (2000), 45(5), 887-892

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See detailEvidence-based medicine. Apport des essais cliniques controles.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(4), 216-9

Controlled clinical trials are the support of Evidence-Based Medicine. In most instances, only them can indeed provide the demonstration of both the efficacy and safety of a pharmacological treatment ... [more ▼]

Controlled clinical trials are the support of Evidence-Based Medicine. In most instances, only them can indeed provide the demonstration of both the efficacy and safety of a pharmacological treatment, based upon rigorous scientific experimental observations avoiding potential bias due to subjective interpretation. In order to be able to extrapolate conclusions of drug trials to clinical practice and to positively influence physician's attitudes, "explanatory" trials, which aim at proving the intrinsic activity of the molecule, should be completed by "pragmatic" trials, which aim at demonstrating the clinical utility of the drug. [less ▲]

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See detailReduced Sperm Counts In Guppies (Poecilia Reticulata) Following Exposure To Low Levels Of Tributyltin And Bisphenol A
Haubruge, Eric ULg; Petit, François ULg; Gage, Mjg.

in Proceedings of the Royal Society B-Biological Sciences (2000), 267(1459),

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See detailImmunocytochemical localization of ionotropic glutamate receptors subunits in the adult quail forebrain
Cornil, Charlotte ULg; Foidart, Agnès ULg; Minet, Arlette ULg et al

in Journal of Comparative Neurology (The) (2000), 428

The excitatory amino acid glutamate is implicated in the central control of many neuroendocrine and behavioral processes. The ionotropic glutamate receptors are usually divided into the N-methyl-D ... [more ▼]

The excitatory amino acid glutamate is implicated in the central control of many neuroendocrine and behavioral processes. The ionotropic glutamate receptors are usually divided into the N-methyl-D-aspartate (NMDA) and non-NMDA (kainate and AMPA) subtypes. Subunits of these receptors have been cloned in a few mammalian species. Information available in birds is more limited. In quail, we recently demonstrated that glutamate agonists (kainate, AMPA, and NMDA) rapidly (within minutes) and reversibly decrease in vitro aromatase activity like several other manipulations affecting intracellular HCa21 pools. Aromatase catalyzes the conversion of androgens into estrogens which is a limiting step in the control by testosterone of many behavioral and physiologic processes. Therefore, glutamate could control estrogen production in the brain, but the anatomic substrate supporting this effect is poorly understood. In quail, aromatase is mainly localized in the preoptic-hypothalamic-limbic system. We visualized here the distribution of the major ionotropic glutamate receptors in quail by immunocytochemical methods by using commercial primary antibodies raised against rat glutamate receptor 1 and receptors 2-3 (GluR1, GluR2/3: AMPA subtype, Chemicon, CA), rat glutamate receptors 5-7 (GluR5-7: kainate subtype, Pharmingen, CA), and rat NMDA receptors (NMDAR1, Pharmingen, CA). Dense and specific signals were obtained with all antibodies. The four types of receptors are broadly distributed in the brain, and, in particular, immunoreactive cells are identified within the major aromatase cell groups located in the medial preoptic nucleus, ventromedial hypothalamus, nucleus striae terminalis, and nucleus taeniae. Dense specific populations of glutamate receptor immunoreactive cells are also present with a receptor subtype-specific distribution in broad areas of the telencephalon. The distribution of glutamate receptors, therefore, is consistent with the idea that these receptors could be located at the surface of aromatase-containing cells and mediate the rapid regulation of aromatase activity in a direct manner. [less ▲]

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See detailLa vie quotidienne à Stavelot-Malmedy autour de l'an mil. Moines & société à travers les Miracula Remacli
George, Philippe ULg

in Bulletin de l'Institut historique liégeois (2000)

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See detailComment j'explore ... les anomalies du metabolisme glucidique, de l'insulinosecretion et de la sensibilite a l'insuline avec une hyperglycemie provoquee par voie orale.
Luyckx, Françoise ULg; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 881-5

Oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes, impaired glucose tolerance or reactive hypoglycaemia. Simultaneous measurements of ... [more ▼]

Oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes, impaired glucose tolerance or reactive hypoglycaemia. Simultaneous measurements of plasma glucose and insulin levels also allow to derive indices of insulin secretion and insulin sensitivity. Whereas OGTT is not considered anymore as the first choice for the diagnosis of diabetes mellitus, it remains useful for studying abnormalities of glucose metabolism as well as of insulin secretion and insulin action. [less ▲]

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See detailLe potentiel evoque cognitif P300 (I): aspects theorique et psychobiologique.
Hansenne, Michel ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2000), 30(4), 191-210

The P300 is a positive wave which arises when an attended stimulus is detected. Its parameters depend on a number of variables, in particular the subject's mental state, the task that has to be ... [more ▼]

The P300 is a positive wave which arises when an attended stimulus is detected. Its parameters depend on a number of variables, in particular the subject's mental state, the task that has to be accomplished, the significance of the stimulus, and the degree of attention. It can be recorded with accuracy, and the different stages of information processing can therefore be analyzed. The P300 wave shows the modifications in neuronal activity which take place during the cognitive process: P300 latency provides an indirect indication of the duration of the processes involved in stimulus discrimination while its amplitude, which is influenced by a number of variables, provides an index of the intensity of the energetic activation or arousal involved. The P300 wave consists of several components which reflect distinct information-processing events (P3a, P3b, P3e, P-SR, P-CR). According to the theoretical models, it is hypothesized that P300 could either represent the adaptation of the working memory to further environmental input ('context updating'), or indicate a closing process ('context closure') in information processing. As regards the physiological aspect of P300 and its association with cortical networks, various studies have suggested that several cortical generators of P300 may co-exist: the medial temporal lobe, the temporo-parietal junction, and the medial and lateral frontal lobe. Psychopharmacological studies have shown that different neurotransmitter systems are involved in the generation and modulation of P300, namely the cholinergic, noradrenergic, dopaminergic, serotoninergic and gabaergic systems. It appears that the noradrenergic agonists increase the amplitude of P300, dopaminergic agonists may have a biphasic effect (increase/reduction), while cholinergic antagonists and gabaergic agonists reduce P300 amplitude and prolong its latency. [less ▲]

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See detailEffect of nicotine on rat gingival fibroblasts in vitro
Lahmouzi, Jamila ULg; Simain-Sato, Franklin ULg; Defresne, Marie-Paule ULg et al

in Connective Tissue Research (2000), 41(1), 69-80

Nicotine from 3 to 5 mM affects growth and survival rate of rat gingival fibroblasts in vitro. Ultrastructural analysis revealed dilated mitochondria and vacuolization in treated cells, suggestive of ... [more ▼]

Nicotine from 3 to 5 mM affects growth and survival rate of rat gingival fibroblasts in vitro. Ultrastructural analysis revealed dilated mitochondria and vacuolization in treated cells, suggestive of necrosis, but increased apoptosis was also revealed by cytometry. On the basis of this in vitro study, it appear that tobacco, through its component nicotine, may directly affect various functions of rat gingival fibroblasts [less ▲]

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See detailEvidence-based medicine. Apport des etudes epidemiologiques.
REGINSTER, Jean-Yves ULg; BETZ, Romain ULg

in Revue Médicale de Liège (2000), 55(4), 211-5

Epidemiological studies, more specifically those related to analytical epidemiology are a major determinant of evidence-based medicine. When classifying the value of the different epidemiological studies ... [more ▼]

Epidemiological studies, more specifically those related to analytical epidemiology are a major determinant of evidence-based medicine. When classifying the value of the different epidemiological studies, based on their level of causality, cohort studies are ranked higher than case-control studies, mainly due to the fact that they allow direct collection of information on exposition to risk factors and health consequences. However, case-control studies can also provide an important information, if a specific effort is dedicated to the analyses of the circumstances of the exposition. Meta-analysis increases, by pooling them, the statistical power of individual studies of limited size. Meta-analysis can also be considered as an important source of evidence in the perspective of evidence-based medicine. [less ▲]

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See detailLégislation et exercice de l'entomologie en Région wallonne
Fagot, Jean ULg; Dethier, Michel ULg

in Notes Fauniques de Gembloux (2000), 41

In Wallonia, a new law is in study to set up a better level of protection for the fauna and the flora, and that, in respect of the european spirit of Nature preservation. On the other hand, a lot of ... [more ▼]

In Wallonia, a new law is in study to set up a better level of protection for the fauna and the flora, and that, in respect of the european spirit of Nature preservation. On the other hand, a lot of territories are raised to different level of protection. The authors enumerate the consequences of the new act and European directives on the practice of the entomology in Wallonia. [less ▲]

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See detailThermal unfolding of an intermediate is associated with non-arrhenius kinetics in the folding of hen lysozyme
Matagne, André ULg; Jamin, M.; Chung, E. W. et al

in Journal of Molecular Biology (2000), 297(1), 193-210

A variety of techniques, including quenched-flow hydrogen exchange labelling monitored by electrospray ionization mass spectrometry, and stopped-flow absorbance, fluorescence and circular dichroism ... [more ▼]

A variety of techniques, including quenched-flow hydrogen exchange labelling monitored by electrospray ionization mass spectrometry, and stopped-flow absorbance, fluorescence and circular dichroism spectroscopy, has been used to investigate the refolding kinetics of hen lysozyme over a temperature range from 2 degrees C to 50 degrees C. Simple Arrhenius behaviour is not observed, and although the overall rate of folding increases from 2 to 40 degrees C, it decreases above 40 degrees C. In addition, the transient intermediate on the major folding pathway at 20 degrees C, in which the alpha-domain is persistently structured in the absence of a stable beta-domain, is thermally unfolded in a sigmoidal transition (T-m approximate to 40 degrees C) indicative of a cooperatively folded state. At all temperatures, however, there is evidence for fast (similar to 25%) and slow (similar to 75%) populations of refolding molecules. By using transition state theory, the kinetic data from various experiments were jointly fitted to a sequential three-state model for the slow folding pathway. Together with previous findings, these results indicate that the alpha-domain intermediate is a productive species on the folding route between the denatured and native states, and which accumulates as a consequence of its intrinsic stability. Our analysis suggests that the temperature dependence of the rate constant for lysozyme folding depends on both the total change in the heat capacity between the ground and transition states (the dominant factor at low temperatures) and the heat-induced destabilization of the alpha-domain intermediate (the dominant factor at high temperatures). Destablization of such kinetically competent intermediate species is Likely to be a determining factor in the non-Arrhenius temperature dependence of the folding rate of those proteins for which one or more intermediates are populated. (C) 2000 Academic Press. [less ▲]

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See detailPharma-clinics. Le medicament du mois. La moxonidine (Moxon).
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(1), 61-3

Moxonidine (Moxon, Solvay Pharma) is the first member of a new class of centrally-acting antihypertensive agents. The selective activation of central I1 imidazoline receptors results in an inhibition of ... [more ▼]

Moxonidine (Moxon, Solvay Pharma) is the first member of a new class of centrally-acting antihypertensive agents. The selective activation of central I1 imidazoline receptors results in an inhibition of peripheral sympathetic activity and produces arterial vasodilatation. Moxonidine is indicated in the treatment of essential arterial hypertension, at a usual daily dose of 0.4 mg (initial dose of 0.2 mg/day), in one administration per day. Its tolerance profile is better than that of other centrally-acting antihypertensive agents which stimulate alpha-2 adrenergic receptors, and similar to that of medications of other classes. As monotherapy, the antihypertensive efficacy of moxonidine is similar to that of most other antihypertensive agents. In case of insufficient response, moxonidine may be associated with other antihypertensive compounds, which leads to a better efficacy with no deterioration of its good tolerance profile. [less ▲]

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See detailAnatocisme et cumul des intérêts en cas de dénonciation du crédit, note sous J.P. Charleroi II, 6 avril 1998
Biquet, Christine ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2000)

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See detailThe effect of PIT tags on growth and physiology of age-0 cultured Eurasian perch Perca fluviatilis of variable size
Baras, E.; Malbrouck, C.; Houbart, M. et al

in Aquaculture (2000), 185

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See detailLa rémunération de base de l'apprenti victime d'un accident du travail
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2000), 25

L'article s'attache à la notion de "rémunération de base" de l'apprenti victime d'un accident du travail.

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See detailRecommandations a propos du traitement de l'hypertension arterielle chez le patient diabetique.
Scheen, André ULg; Rorive, Marcelle ULg; Estrella, F. et al

in Revue Médicale de Liège (2000), 55(5), 376-82

Diabetes mellitus is frequently associated with arterial hypertension and the combination of the two entities markedly increases the cardiovascular risk and accelerates the progression of microangiopathy ... [more ▼]

Diabetes mellitus is frequently associated with arterial hypertension and the combination of the two entities markedly increases the cardiovascular risk and accelerates the progression of microangiopathy (more particularly nephropathy) in both type 1 and type 2 diabetic patients. Numerous international guidelines have been published during the last few years to help the practitioner in targeting ideal arterial blood pressure levels (lower in diabetic than in non-diabetic patients) and in selecting first-choice antihypertensive agents. We will concisely summarize the main messages of these recommendations and insist upon the persistence of uncertainties, or even the existence of inconsistencies, more particularly regarding preferential indications of antihypertensive agents in diabetic patients. [less ▲]

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See detailLa grippe: de la prevention vaccinale au traitement antiviral.
Nkoghe, D.; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(1), 19-23

Influenza is a highly infectious disease responsible for dangerous epidemics, especially in patients at high risk. The vaccine exerts a valuable protective effect estimated up to 70% and is still ... [more ▼]

Influenza is a highly infectious disease responsible for dangerous epidemics, especially in patients at high risk. The vaccine exerts a valuable protective effect estimated up to 70% and is still considered as the key-approach against influenza. Antiviral agents of the first generation (amantadine, rimantadine, ribavirine) have limited use because of poor tolerance and occurrence of resistance. Zanamivir or Relenza, marketed by Glaxo Wellcome, is a new virostatic drug acting as a neuraminidase inhibitor. It prevents the release of new viruses and so stop the propagation of the infection. It must be taken orally by inhalation within 48 hours after the onset of symptoms. The treatment lasts 5 days (10 mg twice daily). Its efficacy has been demonstrated in controlled clinical trials, and its tolerance is generally excellent. However, caution is recommended in patients with asthma and chronic bronchitis because of the potential risk of bronchoconstriction. No resistance has been detected until now. Zanamivir is active on all strains of influenza A and B viruses. [less ▲]

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See detailAffections musculaires et intolrance à l'effort. 1- Pathogénie et approche diagnostique
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical ... [more ▼]

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical diagnosis (is the horse suffering from rhabdomyolysis or not ?) and the aetiology (what is/are the cause(s) of the condition ?) and also to provide an effective treatment [less ▲]

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See detailRythmes du temps: de l'Astronomie à l'Histoire
Biémont, Emile ULg

in Ciel et Terre (2000), 116(3), 72-81

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See detailIdentification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii.
Jarmuszkiwicz, W.; Milani, G.; Fortes, F. et al

in FEBS Letters (2000), 467

An uncoupling protein (UCP) was identified in mitochondria from Candida parapsilosis (CpUCP), a non-fermentative parasitic yeast. CpUCP was immunodetected using polyclonal antibodies raised against plant ... [more ▼]

An uncoupling protein (UCP) was identified in mitochondria from Candida parapsilosis (CpUCP), a non-fermentative parasitic yeast. CpUCP was immunodetected using polyclonal antibodies raised against plant UCP. Activity of CpUCP, investigated in mitochondria depleted of free fatty acids, was stimulated by linoleic acid (LA) and inhibited by GTP. Activity of CpUCP enhanced state 4 respiration by decreasing DeltaPsi and lowered the ADP/O ratio. Thus, it was able to divert energy from oxidative phosphorylation. The voltage dependence of electron flux indicated that LA had a pure protonophoretic effect. The discovery of CpUCP proves that UCP-like proteins occur in the four eukaryotic kingdoms: animals, plants, fungi and protists. [less ▲]

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See detailCoupled thermo-magnetic simulation of a foil-winding transformer connected to a non-linear load
Driesen, Johan; Deliège, Geoffrey ULg; Belmans, Ronnie et al

in IEEE Transactions on Magnetics (2000), 36(4), 1381-1385

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See detailPhylogenetic analysis of the pearlfish Carapini (Ophidiiformes, Carapidae)
Parmentier, Eric ULg; Castillo Cabello, Gabriel ULg; Chardon, Michel ULg et al

in Acta Zoologica (2000), 81

Fishes of the tribe Carapini (Encheliophis and Carapus) share a noteworthy peculiarity: they shelter in holothurian echinoderms or bivalve hosts. Some species are considered parasitic, others commensal ... [more ▼]

Fishes of the tribe Carapini (Encheliophis and Carapus) share a noteworthy peculiarity: they shelter in holothurian echinoderms or bivalve hosts. Some species are considered parasitic, others commensal. This study focuses on the phylogeny of the tribe, using two other Carapidae species as an outgroup (Snyderidia canina and Onuxodon fowleri). Insofar as possible, the selected anatomical and behavioural characters where chosen in an ecomorphological perspective, as features that could be responses to various lifestyle-related constraints. Our character selection also took into account the fact that some features are (presumably) linked. Such features were grouped together as a single trait to avoid their overvaluation. This methodology enabled us to separate commensals from parasites, the former belonging to Carapus and the latter to Encheliophis. Carapus species reflect in their morphology the constraints imposed by a diet of hard, mobile, elusive prey, showing predator-type features: a strong dentition, a wide mouth opening, a robust food intake apparatus. On the other hand, the endoparasitic Encheliophis species show a generally weaker buccal apparatus and narrow mouth opening, in relation to the different constraints of their lifestyle where the diet constraints are less pronounced: they eat body parts of their host. We propose changes in both generic diagnoses and transfer three species from Encheliophis to Carapus. [less ▲]

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See detailLaser-induced transitions between triply excited hollow states
Madsen, L. B.; Schlagheck, Peter ULg; Lambropoulos, P.

in Physical Review Letters (2000), 85(1), 42-45

We present an ab initio calculation of the Li+ photoion yield in the presence of laser coupling between the triply; excited 2s(2)2p(2)P(o) and 2s2p(2) D-2(e) resonances in lithium, the first of which is ... [more ▼]

We present an ab initio calculation of the Li+ photoion yield in the presence of laser coupling between the triply; excited 2s(2)2p(2)P(o) and 2s2p(2) D-2(e) resonances in lithium, the first of which is assumed excited by synchrotron radiation from the ground state. The laser coupling between the triply excited states is shown to lead to a significant and readily measurable modification of the line profile which provides a unique probe of the dipole strength between highly correlated triply excited states. [less ▲]

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See detailPurification and biochemical characterization of the VIM-1 metallo-beta-lactamase.
Franceschini, N.; Caravelli, B.; Docquier, J. D. et al

in Antimicrobial agents and chemotherapy (2000), 44(11), 3003-7

VIM-1 is a new group 3 metallo-beta-lactamase recently detected in carbapenem-resistant nosocomial isolates of Pseudomonas aeruginosa from the Mediterranean area. In this work, VIM-1 was purified from an ... [more ▼]

VIM-1 is a new group 3 metallo-beta-lactamase recently detected in carbapenem-resistant nosocomial isolates of Pseudomonas aeruginosa from the Mediterranean area. In this work, VIM-1 was purified from an Escherichia coli strain carrying the cloned bla(VIM-1) gene by means of an anion-exchange chromatography step followed by a gel permeation chromatography step. The purified enzyme exhibited a molecular mass of 26 kDa in sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and an acidic pI of 5.1 in analytical isoelectric focusing. Amino-terminal sequencing showed that mature VIM-1 results from the removal of a 26-amino-acid signal peptide from the precursor. VIM-1 hydrolyzes a broad array of beta-lactam compounds, including penicillins, narrow- to expanded-spectrum cephalosporins, carbapenems, and mechanism-based serine-beta-lactamase inactivators. Only monobactams escape hydrolysis. The highest catalytic constant/K(m) ratios (>10(6) M(-1). s(-1)) were observed with carbenicillin, azlocillin, some cephalosporins (cephaloridine, cephalothin, cefuroxime, cefepime, and cefpirome), imipenem, and biapenem. Kinetic parameters showed remarkable variability with different beta-lactams and also within the various penam, cephem, and carbapenem compounds, resulting in no clear preference of the enzyme for any of these beta-lactam subfamilies. Significant differences were observed with some substrates between the kinetic parameters of VIM-1 and those of other metallo-beta-lactamases. Inactivation assays carried out with various chelating agents (EDTA, 1,10-o-phenanthroline, and pyridine-2,6-dicarboxylic acid) indicated that formation of a ternary enzyme-metal-chelator complex precedes metal removal from the zinc center of the protein and revealed notable differences in the inactivation parameters of VIM-1 with different agents. [less ▲]

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See detailLe maître de Waha : un exemple de développement durable
Van Ruymbeke, Muriel ULg

in De la Meuse à l'Ardenne (2000), (31), 104-106

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See detailPharma-clinics. Le medicament du mois. La levofloxacine (Tavanic).
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(11), 1015-7

Levofloxacin, the (-)-(S)-enantiomer isolated from the racemate ofloxacin, is launched by Aventis under the trade name of Tavanic. This new oral and parenteral antibiotic belongs to the fluoroquinolone ... [more ▼]

Levofloxacin, the (-)-(S)-enantiomer isolated from the racemate ofloxacin, is launched by Aventis under the trade name of Tavanic. This new oral and parenteral antibiotic belongs to the fluoroquinolone family and exerts a bactericidal activity upon a large spectrum of microorganisms, including Gram negative and Gram positive bacilli (among which Streptococcus pneunomiae), and atypical respiratory pathogens. It also has interesting pharmacokinetic properties. Besides the classical indications of other fluoroquinolones (especially complicated urinary tract infections, including pyelonephritis, and severe skin and soft tissue infections), levofloxacin is indicated for the treatment of acute sinusitis, acute exacerbations of chronic bronchitis and community-acquired pneumonia. [less ▲]

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See detailA simple method for neutrophils isolaton in horse
Votion, Dominique ULg; Harmegnies, N. F.; Lekeux, Pierre ULg

in European Journal of Nuclear Medicine (2000), 27

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See detailLandscape fragmentation assessment using a single measure.
Bogaert, Jan ULg; Van Hecke, P; Salvador-Van Eysenrode, D et al

in Wildlife Society Bulletin (2000), 28(4), 875-881

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See detailConditions radiatives nocturnes hivernales et température de la chaussée : l’exemple de la station météoroutière de Berloz (Belgique)
Erpicum, Michel ULg; Alexandre, Jean ULg; Etienne, Hugues et al

in Publications de l'Association Internationale de Climatologie (2000), 13

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See detailComposition chimique du nététu, condiment alimentaire produit par fermentation des graines du caroubier africain Parkia biglobosa (Jacq.) Benth.
Ndir, Babacar; Lognay, Georges ULg; Wathelet, Bernard ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4(2), 101-105

The seed oils and cakes of netetu of different origins available on the Senegalian market have been studied to evaluate the nutritional potentialities of this important food condiment used in many African ... [more ▼]

The seed oils and cakes of netetu of different origins available on the Senegalian market have been studied to evaluate the nutritional potentialities of this important food condiment used in many African countries. The total oil content ranged from 141 to 349 g.kg-1. Careful gas chromatography and GC-MS (Gas Chromatography-Mass Spectrometry) investigations revealed seven major fatty acids among which linoleic (41.9–46.8% of the total fatty acids), oleic (12.6–14.6%), palmitic (10.2–11.3%), stearic (10.0–13.4%), and behenic (12.6–13.4%) predominate. Significant differences were observed between fermented and non-fermented seeds as well as between netetu of different origins. The tocopherol content was found very low (17.7 to 30.6 mg.100g-1 fat). The total amino acid patterns showed that beside high level of proteins (331 à 540 g.kg-1) and interesting levels of essential constituents, there is an important deficiency of tryptophane, cysteine, methionine and threonine. [less ▲]

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See detailEnantioselective Syntheses and Absolute Configuration of the Ladybird Defence Alkaloids (+)-Calvine and (+)-2-Epicalvine
Laurent, Pascal ULg; Braekman, Jean-Claude; Daloze, Désiré

in European Journal of Organic Chemistry (2000), 11

Enantiomerically pure (+)-calvine (1a) and (+)-2-epicalvine (Ib), two piperidine alkaloids isolated from ladybird beetles of the genus Calvia (Coccinellidae), were synthesized by two different strategies ... [more ▼]

Enantiomerically pure (+)-calvine (1a) and (+)-2-epicalvine (Ib), two piperidine alkaloids isolated from ladybird beetles of the genus Calvia (Coccinellidae), were synthesized by two different strategies starting from (-)-2,3,6,7,8,8a-hexahydro-3-phenyl-5H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile (2). The key steps of these syntheses are the stereocontrolled formation of an asymmetric centre a to the nitrogen atom of 2 and the subsequent introduction of the methoxycarbonylmethyl substituent at the u'-position. Comparison of the optical rotations of the synthetic benzoates (12a) and (12b) with those of the corresponding benzoates derived from the natural compounds has revealed the absolute configuration of (+)-calvine to be (2S,6S) and that of (+)-2-epicalvine to be (2R,6S). [less ▲]

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See detailHigh-Performance Anion-Exchange Chromatography - Dad As A Tool For The Identification And Quantification Of Oligogalacturonic Acids In Pectin Depolymerisation
Deconinck, Thomas J.-M.; Ciza, Antoine; Sinnaeve, Georges et al

in Carbohydrate Research (2000), 329(4),

High-performance anion-exchange chromatography (HPAEC) coupled with a diode array detector (DAD) was used to identify and quantify oligogalacturonic acid components in pectins. Purified pectin lyase and ... [more ▼]

High-performance anion-exchange chromatography (HPAEC) coupled with a diode array detector (DAD) was used to identify and quantify oligogalacturonic acid components in pectins. Purified pectin lyase and polygalacturonase were used to generate unsaturated and saturated oligomers from pectins and sodium polygalacturonate, respectively. This method resulted in a good separation of saturated and unsaturated oligomers up to DP 13. It allowed us to follow polygalacturonase and pectate lyase depolymerisation pathways simultaneously. [less ▲]

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See detailAdenovirus infections in pigeons
Duchatel, Jean-Pierre ULg; Marlier, Didier ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (2000), 144(1), 13-17

This paper describes the different clinical aspects of the adenovirus infections in pigeons. Etiology, epidemiology, pathogenesis, diagnosis and treatment are discussed. The two specific clinical ... [more ▼]

This paper describes the different clinical aspects of the adenovirus infections in pigeons. Etiology, epidemiology, pathogenesis, diagnosis and treatment are discussed. The two specific clinical syndromes of pigeons are mainly described: classical adenovirus and necrotizing-hepatitis. [less ▲]

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See detailDNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase.
Verdemato, P. E.; Brannigan, J. A.; Damblon, Christian ULg et al

in Nucleic Acids Research (2000), 28(19), 3710-8

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and ... [more ▼]

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and thermodynamic studies were carried out to obtain a model of the DNA-binding process. Nuclear magnetic resonance (NMR) studies map the DNA-binding site to helix 5, and a loop region (residues 151-160) which form the recognition helix and the 'wing' of a helix-turn-wing motif, respectively. The NMR data also suggest the absence of a large conformational change in the protein upon binding to DNA. Hence, an O:(6)-methylguanine (O:(6)meG) lesion would be inaccessible to active site nucleophile Cys146 if the modified base remained stacked within the DNA duplex. The experimentally determined DNA-binding face of Ada-C was used in combination with homology modelling, based on the catabolite activator protein, and the accepted base-flipping mechanism, to construct a model of how Ada-C binds to DNA in a productive manner. To complement the structural studies, thermodynamic data were obtained which demonstrate that binding to unmethylated DNA was entropically driven, whilst the demethylation reaction provoked an exothermic heat change. Methylation of Cys146 leads to a loss of structural integrity of the DNA-binding subdomain. [less ▲]

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See detailD'un procès à l'autre - pour une esthétique des médias
Servais, Christine ULg

in Recherches en Communication (2000), 13

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See detailRole of Tir and Intimin in the Virulence of Rabbit Enteropathogenic Escherichia coli (REPEC) Serotype O103:H2
Marchès, O.; Nougayrede, J. P.; Boullier, S. et al

in Infection and Immunity (2000), 68

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See detailL'éclairage : à nouveaux critères, nouveaux outils de mesure, de calcul et de simulation
Eugène, Christian; Rombauts, Patrick; Embrechts, Jean-Jacques ULg et al

in Revue de l'Electricité et de l'Electronique (2000), 7

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See detailEffect of water extract of Moringa oleifera seeds on the hydrolytic microbial species diversity of a UASB reactor treating domestic wastewater.
Kalogo, Y.; Rosillon, Françis ULg; Hammes, F. et al

in Letters in Applied Microbiology (2000), 31(3), 259-264

The effect of a continuous supply of a water extract of Moringa oleifera seeds (WEMOS) on the hydrolytic microbial population of biomass grown in mesophilic upflow anaerobic sludge blanket reactors ... [more ▼]

The effect of a continuous supply of a water extract of Moringa oleifera seeds (WEMOS) on the hydrolytic microbial population of biomass grown in mesophilic upflow anaerobic sludge blanket reactors treating domestic wastewater was investigated. The WEMOS-treated sludge had seemingly a wider diversity, with enterobacter and klebsiella as dominant hydrolytic bacteria, compared with the control sludge. Additional tests indicated that various hydrolytic bacteria could degrade WEMOS. It appeared that a continuous supply of WEMOS to an anaerobic digester, treating domestic wastewater, increased the diversity of hydrolytic bacteria and therefore enhanced the biological start-up of the reactor. [less ▲]

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See detailEffects of cold and warm ischemia on the mitochondrial oxidative phosphorylation of swine lung.
Willet, Katty; Detry, Olivier ULg; Lambermont, Bernard ULg et al

in Transplantation (2000), 69(4), 582-588

BACKGROUND: The aim of the study was to investigate the consequence of warm and cold ischemia on lung mitochondria in order to define bioenergetic limits within lung could be suitable for pulmonary ... [more ▼]

BACKGROUND: The aim of the study was to investigate the consequence of warm and cold ischemia on lung mitochondria in order to define bioenergetic limits within lung could be suitable for pulmonary transplantation. METHODS: Twenty-two pigs underwent lung harvesting after lung flush with Euro-Collins solution. Mitochondria were isolated from fresh lungs, from lungs submitted to 24 or 48 hr of cold ischemia, to 30 or 45 min of warm ischemia, and to 30 min of warm ischemia followed by 24 or 48 hr of cold ischemia. Mitochondrial oxidative phosphorylation parameters were determined in isolated mitochondria by in vitro measurement of oxygen consumption. RESULTS: Relative to controls, mitochondria submitted to cold ischemia showed an alteration in the oxidoreductase activities of the respiratory chain but no membrane permeability alteration. After 48 hr of cold ischemia, there was a decrease in the yield of the oxidative phosphorylation. Thirty minutes of warm ischemia did not alter the mitochondrial respiratory parameters. However, lung submitted to 45 min of warm ischemia showed mitochondrial damage as a decrease in the oxidative phosphorylation efficiency and ADP availability but no change in the oxidoreductase activities. Relative to cold ischemia alone, 30 min of warm ischemia preceding cold ischemia promoted no significant change in the respiratory parameters. CONCLUSIONS: On bioenergetic basis, lung submitted to warm ischemia could be suitable for transplantation if the warm ischemia duration does not exceed 30 min. This could be a major concern in lung procurement from non-heart beating donors. [less ▲]

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See detailLa garantie des droits fondamentaux et la convention européenne des droits de l'homme
Carlier, Jean-Yves ULg

in Revue Québecoise de Droit International (2000), 13(1), 37-62

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See detailPharma-clinics. Le medicament du mois. Le glimepiride (Amarylle).
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(3), 184-6

Glimepiride, commercialized in Belgium under the trade name of Amarylle by Aventis, is a new sulphonylurea compound which is indicated in the treatment of type 2 diabetes, after diet and exercise failure ... [more ▼]

Glimepiride, commercialized in Belgium under the trade name of Amarylle by Aventis, is a new sulphonylurea compound which is indicated in the treatment of type 2 diabetes, after diet and exercise failure. It is available as 2 mg tablets. The initial doses is 1 mg, to be progressively increased up to 4 mg per day, if necessary, with a maximal daily dose of 6 mg. It is recommended to take glimepiride once a day, with the first main meal. Because of a particular binding of this sulphonylurea to the B cells of Langerhans pancreatic islets and, perhaps, of the presence of some extrapancreatic effects, both hypoglycaemic risk and circulating plasma insulin levels are lower with glimepiride than with glibenclamide, the reference sulphonylurea agent used in comparative clinical trials. [less ▲]

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See detailEvidence for expression of some Microtubule-associated Protein 1B in neurons as a plasma membrane glycoprotein.
Franzen, Rachelle ULg; Tanner, Sandy; Jaffe, Howard et al

in Journal of Neurochemistry (2000), 75

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See detailComment évolue la motivation pour l'école et pour la lecture des enfants entre la 1re et la 3e année primaire
Hindryckx, Geneviève ULg; Schockert, Catherine

in Point sur la Recherche en Education (Le) (2000), 14

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See detailAllozyme variation supports an autopolyploid origin and high genetic diversity in tetraploid cranberry, Vaccinium oxycoccos (Ericaceae)
Mahy, Grégory ULg; Bruederle, L. P.; Connors, B. et al

in American Journal of Botany (2000), 87

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See detailLes Scarabées.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (2000), 57

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See detailMieux connaître les élèves: les motivations
Piéron, Maurice ULg; Ledent, Maryse ULg; Delfosse, Catherine ULg et al

in Revue de l'Education Physique (2000), 40(1), 35-43

Dans le cadre des activités de recherche du service de Pédagogie des activités physiques et sportives de l’Université de Liège, les auteurs ont effectué une large étude portant sur le traitement ... [more ▼]

Dans le cadre des activités de recherche du service de Pédagogie des activités physiques et sportives de l’Université de Liège, les auteurs ont effectué une large étude portant sur le traitement différencié des élèves par les enseignements en éducation physique. Cet article présente un aspect des résultats qui n’avaient pas encore été abordés. Il fut préparé à partir d’une étude intitulée «Analyse de la prise en considération des caractéristiques individuelles des élèves dans les décisions et les comportements d'enseignants experts et débutants» subventionnée par la Communauté française de Belgique, Administration de l’Enseignement et de la Recherche Scientifique. [less ▲]

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See detailFour-fold anisotropy of the basal plane magnetization of YNi2B2C: nonlocal effects
Civale, L.; Silhanek, Alejandro ULg; Thompson, J. R. et al

in Physica C: Superconductivity (2000), 341(Part 2), 1299-1300

We present studies of the vortex state magnetization M of a single crystal of the nonmagnetic borocarbide superconductor YNi2B2C. With magnetic field H applied in the square basal plane of the tetragonal ... [more ▼]

We present studies of the vortex state magnetization M of a single crystal of the nonmagnetic borocarbide superconductor YNi2B2C. With magnetic field H applied in the square basal plane of the tetragonal unit cell, M has a four-fold anisotropy. This pi /2 periodicity occurs deep in the superconductive mixed state, with an unusual field dependence, for a range of temperatures T < T-c. The observations are well explained by a generalized London model incorporating non-local electrodynamics, using parameters from complementary experiments. [less ▲]

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See detailL'écriture en chantier. Une brochure destinée aux enseignants du secondaire
Baye, Ariane ULg; Denooz, Régine

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), 7-8

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See detailLes rhyncholites.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (2000), 33

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See detailL'humanisme face au terrorisme
Seron, Vincent ULg

in Cahiers de défense sociale (2000)

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See detailRéhabilitation du pont barrage de Montignie-Saint-Christophe
Lejeune, André ULg; Pirotton, Michel ULg

in Cahiers de l'Urbanisme (Les) (2000)

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See detailQui gagnera la bataille des triptans ?
Schoenen, Jean ULg

in Médi Sphère (2000), (Fév/Mars), 17-18

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