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See detailLATTICE-DYNAMICS AND DIELECTRIC-PROPERTIES OF INCIPIENT FERROELECTRIC TIO2 RUTILE
LEE, C.; Ghosez, Philippe ULg; GONZE, X.

in Physical Review. B : Condensed Matter (1994), 50(18), 13379-13387

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See detailSyndrome naviculaire : anatomie, étio-pathogénie, diagnostic et traitement
Gabriel, Annick ULg; Caudron, I.; Serteyn, Didier ULg et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailHistoire naturelle des anévrysmes de l'aorte abdominale
SakalihasanN, Natzi ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1994), 49(10), 545-52

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See detailModulation of the acetylcholine- and substance P-induced pulmonary edema by calcitonin gene-related peptide in the rabbit.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Journal of Pharmacology and Experimental Therapeutics (The) (1994), 270(1), 30-6

The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the ... [more ▼]

The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the arterial, capillary and venous pressures and the capillary filtration coefficient (Kf,c). CGRP was administered alone or in combination with capsaicin (10(-4) M), acetylcholine (ACh) (10(-11) M to 10(-7) M), substance P (SP) (10(-10) M to 10(-6) M) and serotonin (10(-4) M). The influence of a specific antagonist of CGRP receptors, CGRP8-37 (10(-8) M), on the pulmonary edema induced by these mediators was also considered. CGRP had no direct effect on the vascular pressures or on Kf,c. Capsaicin and serotonin induced an increase in Kf,c of 271 +/- 49% and 676 +/- 147% of base line, respectively. ACh and SP also increased the microvascular permeability, in proportion to the concentration. The effects of capsaicin, ACh and SP have been related to the activation of neurokinin NK1 receptors. Co-administration of CGRP with capsaicin and ACh enhanced the increase in Kf,c induced by these two drugs. By contrast, when co-injected with SP, CGRP inhibited the Kf,c increase induced by 10(-8) M and 10(-7) M of SP (P < .05) and significantly decreased the arterial and capillary pressures. CGRP also partly prevented the pulmonary edema induced by serotonin (P < .05). Pretreatment with CGRP8-37 partly prevented the effects of capsaicin and ACh on Kf,c but bestowed no protection against SP-induced pulmonary edema. These data suggest that CGRP is co-released with SP from the C-fibers upon the action of capsaicin and ACh in the rabbit lung. Because CGRP potentiated the pulmonary edema induced in capsaicin and ACh, but decreased the effects of SP, we hypothesize that CGRP exerts a positive retro-control on the release of neuropeptides by these fibers but can attenuate their effects on the target cells. [less ▲]

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See detailA Consistent next-to-leading order QCD calculation of hadronic diffractive scattering
Cudell, Jean-René ULg; Nguyen, Bao

in Nuclear Physics B (1994), 420

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See detailLes spermatozoïdes ont-ils du nez ?
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Parmentier, M. et al

in Medecine Sciences : M/S (1994), 10

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See detailInactivation of alpha(2)-Macroglobulin by Activated Human Polymorphonuclear Leukocytes.
Deby, Ginette ULg; Croisier, Jean-Louis ULg; Camus, Gérard et al

in Mediators of Inflammation (1994), 3(2), 117-23

The proteolytic activity of trypsin releases the dye Remazol Brilliant Blue from its high molecular weight substrate, the skin powder (Hide Powder Azure, Sigma), with an increase in absorbance at 595 nm ... [more ▼]

The proteolytic activity of trypsin releases the dye Remazol Brilliant Blue from its high molecular weight substrate, the skin powder (Hide Powder Azure, Sigma), with an increase in absorbance at 595 nm. Active alpha(2)- macroglobulin (80 mug/ml) totally inhibits the proteolytic activity of trypsin (14 mug/ml) by trapping this protease. But after a 20 min incubation of alpha(2)-macroglobulin at 37 degrees C with 2 x 10(6) human polymorphonuclear leukocytes activated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (10(-7) M) and cytochalasin B (10(-8) M), 100% of trypsin activity was recovered, indicating a total inactivation of alpha(2)-macroglobuHn. Incubation with granulocyte myeloperoxidase also inactivates alpha(2)-macroglobulin. Hypochlorous acid, a by-product of myeloperoxidase activity, at a concentration of 10(-7) M also inactivates alpha(2)-macroglobulin, which indicates that an important cause of alpha(2)-macroglobulin inactivation by activated polymorphonuclear leukocytes could be the activity of myeloperoxidase. [less ▲]

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See detail2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle; Dive, Georges ULg; Delaude, Clément et al

in Phytochemistry (1994), 35(2), 533-536

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based ... [more ▼]

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests. [less ▲]

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See detailL'inventaire forestier régional wallon: brève présentation méthodologique.
Lecomte, H.; Rondeux, Jacques ULg

in Silva Belgica (1994), 101(6), 9-16

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie ... [more ▼]

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie [RONDEUX et al., 1984]. Cet inventaire s’appuyant sur un échantillonnage systématique simple était destiné à fournir un état des lieux de la forêt wallonne de l’époque ; il a notamment permis de confirmer ou de mettre en évidence plusieurs éléments essentiels pour l’avenir du patrimoine forestier wallon [RONDEUX et al., 1986] : - le vieillissement de la hêtraie ardennaise ; - l’importante disponibilité en bois d’épicéa ; - les écarts entre les surfaces forestières observées et celles du recensement officiel. Depuis la fin de cet inventaire en 1984, aucune mise à jour n’a été programmée et en conséquence, ses résultats ont perdu leur fiabilité notamment en raison des accidents météorologiques de la dernière décennie. En 1988, l’Exécutif de la Région Wallonne, conscient de l’importance de la forêt en tant que première ressource naturelle renouvelable de la Wallonie, a sollicité la Faculté des Sciences agronomiques de Gembloux en vue de finaliser une recherche destinée à concevoir une méthodologie d’inventaire forestier permanent. Les conclusions de cette étude ont été déposées fin 1993 [LECOMTE, 1994], ce qui a permis de lancer dès février 1994 la phase opérationnelle du premier inventaire forestier permanent pour la Wallonie. Dans les lignes qui suivent, nous aborderons successivement les objectifs de l’inventaire (paragraphe 2) ainsi que les principes généraux qui le régissent (paragraphe 3). Le cheminement de l’information sera décrit depuis la récolte des données (paragraphe 4) jusqu’à la publication des résultats (paragraphe 7) en passant par le traitement et l’exploitation des données (paragraphes 5 et 6). En guise de conclusions, nous émettrons quelques réflexions issues de notre propre expérience (paragraphe 8). [less ▲]

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See detailL'agrégé nouveau est arrivé !
Jadoulle, Jean-Louis ULg

in Bulletin de Clio (1994)

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See detailLes défis des familles recomposées
Guillaume, Jean-François ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 6(novembre-décembre), 30-36

Dans un contexte de croissance des recompositions conjugales après divorce, la prise en charge des tâches parentales constitue un défi inédit, où il s'agit pour les uns de retrouver des repères bien ... [more ▼]

Dans un contexte de croissance des recompositions conjugales après divorce, la prise en charge des tâches parentales constitue un défi inédit, où il s'agit pour les uns de retrouver des repères bien connus, et pour les autres, d'imaginer un nouvel ordre éducatif. Une nouvelle histoire doit alors être créée, et dans ce "bricolage", chacun ne dispose pas des mêmes ressources pour trouver sa place. [less ▲]

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See detailLogiciel d'aide à la détermination détaillée du poids et du bilan électrique d'un navire
Marchal, Jean ULg; Hage, André ULg; Rodriguez, S.

in Bulletin de l'Association Technique Maritime et Aéronautique (1994)

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See detailEpidural anesthesia impairs both central and peripheral thermoregulatory control during general anesthesia.
Joris, Jean ULg; Ozaki, Makoto; Sessler, Daniel I et al

in Anesthesiology (1994), 80(2), 268-77

BACKGROUND: The authors tested the hypotheses that: (1) the vasoconstriction threshold during combined epidural/general anesthesia is less than that during general anesthesia alone; and (2) after ... [more ▼]

BACKGROUND: The authors tested the hypotheses that: (1) the vasoconstriction threshold during combined epidural/general anesthesia is less than that during general anesthesia alone; and (2) after vasoconstriction, core cooling rates during combined epidural/general anesthesia are greater than those during general anesthesia alone. Vasoconstriction thresholds and heat balance were evaluated under controlled circumstances in volunteers, whereas the clinical importance of intraoperative thermoregulatory vasoconstriction was evaluated in patients. METHODS: Five volunteers were each evaluated twice. On one of the randomly ordered days, epidural anesthesia (approximately T9 dermatomal level) was induced and maintained with 2-chloroprocaine. On both study days, general anesthesia was induced and maintained with isoflurane (0.7% end-tidal concentration), and core hypothermia was induced by surface cooling and continued for at least 1 h after fingertip vasoconstriction was observed. Patients undergoing colorectal surgery were randomly assigned to combined epidural/enflurane anesthesia (n = 13) or enflurane alone (n = 13). In appropriate patients, epidural anesthesia was maintained by an infusion of bupivacaine. The core temperature that triggered fingertip vasoconstriction identified the threshold. RESULTS: In the volunteers, the vasoconstriction threshold was 36.0 +/- 0.2 degrees C during isoflurane anesthesia alone, but significantly less, 35.1 +/- 0.7 degrees C, during combined epidural/isoflurane anesthesia. Cutaneous heat loss and the rates of core cooling were similar 30 min before vasoconstriction with and without epidural anesthesia. In the 30 min after vasoconstriction, heat loss decreased 33 +/- 13 W when the volunteers were given isoflurane alone, but only 8 +/- 16 W during combined epidural/isoflurane anesthesia. Similarly, the core cooling rates in the 30 min after vasoconstriction were significantly greater during combined epidural/isoflurane anesthesia (0.8 +/- 0.2 degrees C/h) than during isoflurane alone (0.2 +/- 0.1 degrees C/h). In the patients, end-tidal enflurane concentrations were slightly, but significantly, less in the patients given combined epidural/enflurane anesthesia (0.6 +/- 0.2% vs. 0.8 +/- 0.2%). Nonetheless, the vasoconstriction threshold was 34.5 +/- 0.6 degrees C in the epidural/enflurane group, which was significantly less than that in the other patients, 35.6 +/- 0.8 degrees C. When the study ended after 3 h of anesthesia, patients given combined epidural/enflurane anesthesia were 1.2 degrees C more hypothermic than those given general anesthesia alone. The rate of core cooling during the last hour of the study was 0.4 +/- 0.2 degrees C/h during combined epidural/enflurane anesthesia, but only 0.1 +/- 0.3 degrees C/h during enflurane alone. CONCLUSIONS: These data indicate that epidural anesthesia reduces the vasoconstriction threshold during general anesthesia. Furthermore, the markedly reduced rate of core cooling during general anesthesia alone illustrates the importance of leg vasoconstriction in maintaining core temperature. [less ▲]

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See detailUtilisation des moules comme bioindicateurs de la pollution en métaux lourds du littoral belge
Gobert, Sylvie ULg; Langer, Alain; Daemers-Lambert, Claire et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 203-210

From 1991 till 1993, a study of the Belgian coast pollution by heavy metals using Mytilus edulis as a bioindicator was performed. The Pb, Cr, Cu and Ti concentrations decreased from 1987 till 1991 but ... [more ▼]

From 1991 till 1993, a study of the Belgian coast pollution by heavy metals using Mytilus edulis as a bioindicator was performed. The Pb, Cr, Cu and Ti concentrations decreased from 1987 till 1991 but then remained unchanged till 1993. Cd contamination is increasing from 1987. Hg, whose concentration had been shown to decrease from 1975 to 1991, now reaches the same values as in 1986. The O/N measurements performed on the mussels suggest an increase of the general pollution level of the Belgian coast. However, feeding, spawning and detoxification processes are also able to influence the O/N ratio and should be taken into account in the framework of a global assessment of the pollution level of the Belgian coast [less ▲]

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See detailHigh-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery
Janssens, Marc ULg; Joris, Jean ULg; David, Jean-Louis et al

in Anesthesiology (1994), 80

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See detailOPTIMIZATION OF LIPASE-CATALYZED SYNTHESIS OF CITRONELLYL ACETATE IN SOLVENT-FREE MEDIUM
Fonteyn, Fabienne ULg; Blecker, Christophe ULg; Lognay, Georges ULg et al

in Biotechnology Letters (1994), 16(7), 693-696

Citronellol esterification catalyzed by Candida antarctica lipase is performed with high yields (74%) in a solvent-free medium. The use of dessicants gives a 10% yield enhancement and substrate excess ... [more ▼]

Citronellol esterification catalyzed by Candida antarctica lipase is performed with high yields (74%) in a solvent-free medium. The use of dessicants gives a 10% yield enhancement and substrate excess consumption by adding calculated amounts of acetic acid lead to a 80% pure citronellyl acetate. Quantities up to 100 ml are treated with success. [less ▲]

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See detailYeast excision repair RAD2 encodes a single-stranded DNA endonuclease
Habraken, Yvette ULg; Sung, Partick; Prakash, Louise et al

in Nature (1993), 366

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See detailMagnetic Eden model
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg; Cloots, Rudi ULg

in Europhysics Letters [=EPL] (1993), 24(8), 629-634

We introduce the <<Magnetic Eden Model(s)>>. It consists in the usual Eden growth model(s), but allowing for the elements of the growth to have an extra degree of freedom (a <<spin>>). The growth is ... [more ▼]

We introduce the <<Magnetic Eden Model(s)>>. It consists in the usual Eden growth model(s), but allowing for the elements of the growth to have an extra degree of freedom (a <<spin>>). The growth is controlled by a condition depending on the <<magnetic state>> of the perimeter (through some <<spin coupling>>) and an external parameter, the <<magnetic field>>. Even though these words seem to refer to some <<energetic condition>> the growth model is of purely kinetic origin. This is demonstrated by exactly solving the 1-dimensional growth model for a semi-open chain, and, e.g. finding the correlation functions. In two-dimensions, simulations of clusters lead us to show that the perimeter growth exponent is coupling dependent. We show the morphologies of growth clusters on a <<phase diagram>> and indicate the <<physical origin>> and transition(s) between compact and lacunar clusters. [less ▲]

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See detailFully Automated Determination of Sulfamethazine in Ovine Plasma Using Solid-Phase Extraction on Disposable Cartridges and Liquid Chromatography
Hubert, Philippe ULg; Chiap, Patrice ULg; Evrard, Brigitte ULg et al

in Journal of Chromatography. A (1993), 622(1), 53-60

An automatic sample preparation procedure followed by on-line injection of the sample extract into a HPLC system has been developed for the quantitative analysis of sulfamethazine and its N4-acetyl ... [more ▼]

An automatic sample preparation procedure followed by on-line injection of the sample extract into a HPLC system has been developed for the quantitative analysis of sulfamethazine and its N4-acetyl metabolite in ovine plasma. The sample clean-up was performed by solid-phase extraction (SPE) on C18 disposable extraction cartridges (DECs). All the sample handling operations were effected by a robotic auto-sampler. The DEC was first conditioned with methanol and phosphate buffer pH 7.4. After loading 1.0 ml of plasma sample onto the DEC, the latter was washed with the same buffer. The elution step was performed with methanol (0.25 ml) and the eluate was then diluted by adding 0.75 ml volume of phosphate buffer pH 6.4. A 20-microliters volume of the resultant solution was injected onto an octadecyl silica column preceded by a short guard column. The HPLC mobile phase was methanol-phosphate buffer pH 6.4 (25:75, v/v). Sulfamethazine and N4-acetylsulfamethazine were determined photometrically at 262 nm. Under these conditions, linear calibration curves ranging from 2 to 250 micrograms ml-1 have been obtained for both compounds. Drug recoveries were higher than 90% and typical relative standard deviation values were 0.7% (within-day) and 2.0% (between-day) at a plasma concentration of 50 micrograms ml-1. [less ▲]

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See detailAnionic polymerization of acrylic monomers. 11 NMR investigation of the mixed complexation of methyl α-lithioisobutyrate and lithium chloride
Wang, Jin-Shan; Warin, R.; Jérôme, Robert ULg et al

in Macromolecules (1993), 26

Solutions of methyl α-lithioisobutyrate (MIBLi) in THF added with various amounts of lithium chloride (LiCl) have been analyzed by Li-7 NMR spectroscopy in a wide range of temperatures. Although below ca ... [more ▼]

Solutions of methyl α-lithioisobutyrate (MIBLi) in THF added with various amounts of lithium chloride (LiCl) have been analyzed by Li-7 NMR spectroscopy in a wide range of temperatures. Although below ca. 205 K tetramers of MIBLi have been reported to be in equilibrium with dimers, 1/1 and 2/1 LiCl/MIBLi mixed complexes instantaneously form upon the addition of 1 and 2 mol equiv of LiCl, respectively. Further addition of LiCl more likely promotes the formation of a less stable 3/1 complex. Both 1/1 and 2/1 adducts are stable between -80-degrees-C and at least +12-degrees-C. From C-13 NMR spectroscopy, it appears that the addition of an equimolar amount of LiCl to the MIBLi solution in THF is at the origin of a ca. 7.0 ppm upfield shift of the metalated α-carbon compared to the tetrameric MIBLi species and a ca. 1.0 ppm downfield shift with respect to the dimeric MIBLi. However, the charge distribution over the carbanion does not change anymore when the amount of LiCl exceeds 1 mol equiv. In contrast to nonligated MEBLi, the OR group has a considerable rotational freedom in LiCl-modified MIBLi. A comparison of the structure and dynamics of the LiCl-modified MIBLi species in THF at 197 K with the characteristic features of the anionic polymerization of MMA under the same conditions suggests that the formation of one type of LiCl-complexed species has a decisive effect on the control of the living polymerization of MMA. This conclusion is in agreement with a kinetic study carried out by Muller for the same system. [less ▲]

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See detailSelective gravitational microlensing and line profile variations in the BAL quasar H 1413+117
Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1993), 280

In order to interpret the spectral differences observed between the four images of the gravitationally lensed broad absorption line (BAL) quasar H 1413+117, we have investigated the effect on the line ... [more ▼]

In order to interpret the spectral differences observed between the four images of the gravitationally lensed broad absorption line (BAL) quasar H 1413+117, we have investigated the effect on the line profiles of the selective magnification of individual BAL clouds by gravitational microlenses. Since microlenses magnify both the selected cloud and the whole BAL region, this effect is only differential, and general constraints on its capability to produce spectral variations have been derived. Considering simple but realistic models for the microlenses, we find that the selective magnification of a relatively large optically thick BAL cloud can be at the origin of the spectral differences reported between the components of H 1413+117. However, a very precise configuration is needed: the magnified cloud must be at the border of the BAL region which must itself partially lie in a region of strong de-magnification. The fine tuning of the parameters mecessary to reproduce the observations either seriously questions this kind of interpretation or puts strong constraints on the lensing models. Another interpretation of the observed line profile differences in terms of effects due to microlensing is also briefly discussed. [less ▲]

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See detailComplement activation during cardiopulmonary bypass in infants and children: Relation to postoperative multiple system organ failure
Seghaye, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1993), 106(6), 978-987

Twenty-nine children 3 months to 17 years of age undergoing operations for congenital heart disease were included in this prospective study. Complement activation, activation of the plasma contact system ... [more ▼]

Twenty-nine children 3 months to 17 years of age undergoing operations for congenital heart disease were included in this prospective study. Complement activation, activation of the plasma contact system, leukocytes, leukocyte elastase release, and C-reactive protein were studied during and after cardiopulmonary bypass for the first postoperative week and related to multiple system organ failure occurring in eight (27.5 %) of the 29 children. During cardiopulmonary bypass complement activation via the alternative pathway as indicated by significant conversion of C3 (expressed by C3d/C3) and abnormally high C5a values at the end of cardiopulmonary bypass without consumption of C4 was shown in all children. At the end of cardiopulmonary bypass, C3 conversion was significantly higher in the eight patients with multiple system organ failure than in the others (p < 0.05), whereas no difference in C5a level was shown. All children had a significant increase in leukocyte count directly after protamine administration (p < 0.0001) and elastase release during cardiopulmonary bypass that was significantly higher in patients with multiple system organ failure than in those without (p < 0.05). Consumption of prekallikrein as an indicator of activation of the Hageman system was not detectable during cardiopulmonary bypass in any child. After cardiopulmonary bypass, in patients without multiple system organ failure, C3d/C3 decreased and reached preoperative values within the first postoperative week, whereas, in patients with multiple system organ failure, C3d/C3 increased further, reaching a maximal value on the third postoperative day. In comparison with patients without multiple system organ failure, patients with multiple system organ failure showed a severe decrease of C4 (with minimal values on the third postoperative day), suggesting consumption by activation of the classic pathway of the complement system or a hepatic synthesis deficiency. Prekallikrein values were also significantly lower in patients with multiple system organ failure than in the others, with a maximal difference on the third postoperative day (p < 0.005). C-reactive protein was significantly lower in patients with multiple system organ failure than in the others for the first 2 postoperative days (p < 0.05), probably because of severe hepatic failure in patients with multiple system organ failure. This study demonstrates that, in children, cardiopulmonary bypass induces complement activation principally via the alternative pathway. It suggests a relationship between complement activation and multiple system organ failure observed in the postoperative period. Furthermore, it points out the role of multiple system organ failure itself on the C3 conversion and on the synthesis of the markers of the inflammatory response in children after heart operations. [less ▲]

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See detailIpriflavone: Pharmacological Properties and Usefulness in Postmenopausal Osteoporosis
Reginster, Jean-Yves ULg

in Bone and Mineral (1993), 23(3), 223-32

Ipriflavone (IP) is an isoflavone derivative available in several countries for investigational and/or therapeutic use. Inhibition of bone resorption was demonstrated in several models, both in vitro and ... [more ▼]

Ipriflavone (IP) is an isoflavone derivative available in several countries for investigational and/or therapeutic use. Inhibition of bone resorption was demonstrated in several models, both in vitro and in vivo for IP and its metabolites. Their mechanisms of action on bone are not yet fully elucidated but some of them are widely accepted. IP does not possess, per se, any estrogenic activity. It appears that IP-related inhibition of bone resorption might be mediated by an indirect effect on osteoclast and related to an inhibition of recruitment and/or differentiation of pre-osteoclast, maybe through a modulation of osteoblast response to PTH. Clinical studies in Paget's disease of bone or primary hyperparathyroidism have confirmed preferential inhibition of bone resorption suggesting a clinical interest in postmenopausal osteoporosis. Preliminary (1 year) results of double blind placebo controlled studies designed in postmenopausal and senile osteoporosis confirm a reduction in bone turnover rate in patients treated with 600 mg/day of IP, resulting in a significant bone-sparing effect both at lumbar and radial levels. All clinical and pharmacological trials confirm a very good tolerance of IP with a frequency of adverse reactions equal to that observed during administration of a placebo. Providing ongoing studies will confirm the actual promising preliminary results, IP seems a very interesting new non hormonal approach for prevention and treatment of postmenopausal and senile osteoporosis. [less ▲]

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See detailLe come back de Nyles Jones a.k.a. GUITAR GABRIEL
Sacré, Robert ULg

in Soul Bag (1993), (129),

Vie et oeuvre de Robert Lewis 'Nyles' JONES ou Guitar Gabriel

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See detailSome Principles and Applications of Adaptive Mathematical Morphology for Range Imagery
Verly, Jacques ULg; Delanoy, Richard L.

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (1993), 32(12), 3295-3306

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See detailEtre ou non branché aux médias
Leclercq, Dieudonné ULg

in Emergence. Revue proposée par l'ICC en collaboration avec MEDIA ANIMATION et le CFA (1993), 21

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See detailField Efficacy of Injectable Moxidectin in Cattle Naturally Infested with Chorioptes Bovis and Sarcoptes Scabiei
Losson, Bertrand ULg; Lonneux, J. F.

in Veterinary Parasitology (1993), 51(1-2), 113-21

Field efficacy of moxidectin, a macrocyclic lactone endectocide, was evaluated in cattle naturally infested with Chorioptes bovis and Sarcoptes scabiei. Eight animals were allocated to two groups of four ... [more ▼]

Field efficacy of moxidectin, a macrocyclic lactone endectocide, was evaluated in cattle naturally infested with Chorioptes bovis and Sarcoptes scabiei. Eight animals were allocated to two groups of four animals each, based on parasitological and clinical status. Animals of the treated group received one subcutaneous injection of injectable moxidectin at 0.2 mg kg-1 body weight on Day 0. Individuals of the control group received emergency treatment of a single injection of moxidectin at 0.2 mg kg-1 body weight on Day 28. Efficacy was assessed by (a) taking skin samples from each animal on Days 0, 7, 14, 21, 28, 42 and 56 and observing the numbers of viable mite stages and species and (b) clinical examination of animals on Days 7, 14, 21, 28, 42 and 56 with the percentage of affected body surface calculated for each animal on Days 0, 28 and 56. On the basis of the geometric means from treated and control animals, the percentage reductions in the total numbers of living C. bovis mites on Days 7, 14, 21 and 28 were 69, 87, more than 99 and 98, respectively. However, at the end of the trial, only two animals were negative for C. bovis. The percentage reductions in the total numbers of S. scabiei on Days 7, 14, 21 and 28 were 93, 100, 100 and 100, respectively. Clinical indices of the treated animals showed a sharp decrease in the affected body surface area from a mean of 43.6% on Day 0 to 0.9% and 0% on Days 28 and 56, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailMediterranean small mammals and insular syndrome: biometrical study of the long tailes field mouse (Apodemus sylavticus) (Rodentia Muridae) of Corsica
Libois, Roland ULg; Fons, Roger; Bordenave, Dominique

in Bonner Zoologische Beiträge (1993), 44(3-4), 147-163

The presence in Corsica of a field mouse is well known. Several authors have noted some of its morphological peculiarities but it was only recently (1980) that the presence of A. sylvaticus was ... [more ▼]

The presence in Corsica of a field mouse is well known. Several authors have noted some of its morphological peculiarities but it was only recently (1980) that the presence of A. sylvaticus was establblished with certainty. However, this evidence is based on a check of a limited number of individuals originating from a single locality. In order to generalize these observations, we performed o biochemical test on six Corsican mice caught in three distinct localites and a morpho biometrical study of 491 skulls. The results show that A. sylvaticus is spread all over the island and that A. flavicollis is probably absent. No sexual dimorphism was found but strong spatial variations in the cranial measurements were ividenced. There are far less important between the various Corsican sub samples than between the insular and the continenecal mice. The evolutionary and adaptive significance of the increase in size of insular mice is discussed in relation to the theory of island biogeography and to the present knowledge on the history of the mammalian settlement of the island. [less ▲]

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See detailOppervlakte-biopsie
Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Nederlands Tijdschrift voor Dermatologie en Venereologie (1993), 3

Superficial skin surface stripping (SSSS) enables the study of the outermost cell layers of the stratum corneum. In this article we review the diagnostic value and the research possibilities offered by ... [more ▼]

Superficial skin surface stripping (SSSS) enables the study of the outermost cell layers of the stratum corneum. In this article we review the diagnostic value and the research possibilities offered by SSSS. This technique is non invasive and provides information useful in the differential diagnosis of erythematosquamous and eczematous lesions and pigmented neoplasms. For research purposes SSSS can also be used as substratum for scanning electron microscopic assessments and biochemical analysis. [less ▲]

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See detailCalcitonin for Prevention and Treatment of Osteoporosis
Reginster, Jean-Yves ULg

in American Journal of Medicine (1993), 95(5A), 44-47

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first year of the menopause. Strong evidence exists that half that ... [more ▼]

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first year of the menopause. Strong evidence exists that half that dose may also be sufficient to prevent trabecular bone loss and that higher doses (> or = 200 IU/day) induce a significant increase in spinal bone mineral content. Calcium supplements should be systemically administered when calcitonin is given, particularly at high doses. Rectal calcitonin seems also to be an efficient alternative in prevention of trabecular bone loss. Further studies are required to evaluate the effect of calcitonin in prevention of cortical bone loss. In established osteoporosis calcitonin may prevent further bone loss at trabecular and cortical sites. A similar benefit is obtained following parenteral or nasal administration of the drug. Long-term administration of nasal salmon calcitonin induces a significant dose-dependent gain of bone at the lumbar spine, whereas discontinuous therapy with a ratio of 1:2 or 2:3 between the treatment and nontreatment periods is the best regimen for cortical bone. Epidemiological, retrospective, and prospective studies provide a convergent network of evidence that calcitonin administration in osteoporosis contributes to reduce significantly the frequency of subsequent fractures, both in the spine and in the hip. Finally, in established osteoporosis, nasal calcitonin possesses a potent analgesic effect, reduces the duration of bed confinement, and decreases the number of concomitant analgesic medications. The well-demonstrated effects of nasal calcitonin permit it to be considered as a highly rational solution for the prevention and the treatment of postmenopausal osteoporosis. [less ▲]

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See detailMacromolecular engineering of polylactones and polylactides. 14. A 13C and 27Al NMR study of the effect of γ-butyrolactone on the structure of aluminum isopropoxide in toluene
Ropson, Nathalie; Dubois, Philippe; Jérôme, Robert ULg et al

in Macromolecules (1993), 26(24), 6378-6385

Solutions of Al isopropoxide in toluene have been investigated by C-13 and Al-27 NMR spectroscopy. Since Al(OiPr)3 is currently used as an initiator for the living polymerization of epsilon-caprolactone ... [more ▼]

Solutions of Al isopropoxide in toluene have been investigated by C-13 and Al-27 NMR spectroscopy. Since Al(OiPr)3 is currently used as an initiator for the living polymerization of epsilon-caprolactone, special attention has been paid to the effect of the monomer on the coordinative structure of Al(OiPr3) in toluene. Gamma-butyrolactone (BL) has been chosen as a nonpolymerizable model, representative of epsilon-caprolactone. The NMR spectra have been recorded at various concentrations of gamma-butyrolactone and temperatures. As a rule, Al(OiPr)3 is coordinatively aggregated in toluene in such a way that tetrameric and trimeric species are in equilibrium. Upon the addition of BL, this equilibrium is shifted toward the formation of an octahedric [Al(OiPr)3.3BL] mixed tetramer coexisting with [Al(OiPr)3]4 tetramers, the external tetrahedric Al atoms of which are coordinated with extra BL molecules. In the presence of a large excess of BL, only the mixed tetramer persists, which suggests that the single [Al(OiPr)3.3M] species would be the actual initiator for the ring-opening polymerization of cyclic monomers M, such as epsilon-caprolactone, lactides, glycolide, and cyclic anhydrides. [less ▲]

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See detailATMOS ATLAS-1 MEASUREMENTS OF SULFUR-HEXAFLUORIDE (SF6) IN THE LOWER STRATOSPHERE AND UPPER TROPOSPHERE
Rinsland, C. P.; Gunson, M. R.; Abrams, M. C. et al

in Journal of Geophysical Research (1993), 98(D11), 20491-20494

Vertical profiles of sulfur hexafluoride (SF6) in the lower stratosphere and upper troposphere have been retrieved from 0.01-cm-1 resolution infrared solar occultation spectra recorded by the Atmospheric ... [more ▼]

Vertical profiles of sulfur hexafluoride (SF6) in the lower stratosphere and upper troposphere have been retrieved from 0.01-cm-1 resolution infrared solar occultation spectra recorded by the Atmospheric Trace Molecule Spectroscopy (ATMOS) Fourier transform spectrometer during the ATLAS (Atmospheric Laboratory for Applications and Science) 1 shuttle mission of March 24 to April 2, 1992. Based on measurements of the unresolved absorption by the SF6 nu3 band Q branch at 947.9 cm-1, average SF6 volume mixing ratios and 1-sigma uncertainties of 3.20 +/- 0.54 parts per trillion by volume (pptv; 10(-12) ppv) at 200 mbar (approximately 11.8 km) declining to 2.86 +/- 0.29 pptv at 100 mbar (approximately 16.2 km) and 1.95 +/- 0.50 pptv at 30 mbar (approximately 23.9 km) have been retrieved. The profiles show no obvious dependence with latitude over the range of the measurements (eight occultations spanning 28-degrees-S to 54-degrees-S). Assuming an exponential growth model and applying a correction for the interhemispheric concentration difference, an average SF6 rate of increase of 8.7 +/- 2.2% per year, 2 sigma, between 12 and 18 km has been derived by fitting the present measurements, ATMOS measurements from the April-May 1985 Spacelab 3 mission, and balloon-borne IR measurements obtained in March 1981 and June 1988. [less ▲]

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See detailSurface concentration of chain ends in polystyrene determined by static secondary ion mass spectroscopy
Affrossman, S.; Hartshorne, M.; Jérôme, Robert ULg et al

in Macromolecules (1993), 26(23), 6251-6254

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See detailLongterm Photometry of Variables at ESO - Part Two - the Second Data Catalogue 1986-1990
Sterken, C.; Manfroid, Jean ULg; Anton, K. et al

in Astronomy and Astrophysics. Supplement Series (1993), 102

In this paper we present the second catalogue of photometric data in the Strömgren system obtained during the period October 1986- September 1990 in the framework of the Long-Term Photometry of Variables ... [more ▼]

In this paper we present the second catalogue of photometric data in the Strömgren system obtained during the period October 1986- September 1990 in the framework of the Long-Term Photometry of Variables (LTPV) program at the European Southern Observatory. The catalogue is available in computer readable form at the Centre de Données de Strasbourg. [less ▲]

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See detailInteractions between Active-Site-Serine Beta-Lactamases and Mechanism-Based Inactivators: A Kinetic Study and an Overview
Matagne, André ULg; Ghuysen, M. F.; Frère, Jean-Marie ULg

in Biochemical Journal (1993), 295((Pt 3)), 705-711

The interactions between three class A beta-lactamases and three beta-lactamase inactivators (clavulanic acid, sulbactam and olivanic acid MM13902) were studied. Interestingly, the interaction between the ... [more ▼]

The interactions between three class A beta-lactamases and three beta-lactamase inactivators (clavulanic acid, sulbactam and olivanic acid MM13902) were studied. Interestingly, the interaction between the Streptomyces cacaoi beta-lactamase and clavulanate indicated little irreversible inactivation. With sulbactam, irreversible inactivation was found to occur with the three studied enzymes, but no evidence for transiently inactivated adducts was found. Irreversible inactivation of the S. albus G and S. cacaoi enzymes was particularly slow. With olivanate, irreversible inactivation was also observed with the three enzymes, but with the S. cacaoi enzyme, no hydrolysis could be detected. A tentative summary of the results found in the literature is also presented (including 6 beta-halogenopenicillanates), and the general conclusions underline the diversity of the mechanisms and the wide variations of the rate constants observed when class A beta-lactamases interact with beta-lactamase inactivators, in agreement with the behaviours of the same enzymes towards their good and poor substrates. [less ▲]

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See detailSite-directed mutagenesis of dicarboxylic acid residues of the penicillin-binding module of the Escherichia coli penicillin-binding protein 3
Goffin, Colette ULg; Ayala, J. A.; Nguyen-Distèche, Martine ULg et al

in FEMS Microbiology Letters (1993), 113(3), 247-251

The glutamic acid E396, aspartic acid D409 and glutamic acid E411 residues of the Escherichia coli penicillin-binding protein 3 were each converted into an alanine residue. As deduced from penicillin ... [more ▼]

The glutamic acid E396, aspartic acid D409 and glutamic acid E411 residues of the Escherichia coli penicillin-binding protein 3 were each converted into an alanine residue. As deduced from penicillin-binding and complementation experiments, none of these dicarboxylic acid residues is involved in the mechanism of acylation by penicillin and none of them is essential for the in vivo functioning of the PBP. The mutation E396, however, causes an increased thermolability of the protein. [less ▲]

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See detailFormation of P Cygni Line Profiles in Relativistically Expanding Atmospheres. II. The Effect of the Continuum Frequency Shape and Limb Darkening of the Core
Hutsemekers, Damien ULg

in Astrophysical Journal (1993), 417

Abstract image available at: http://adsabs.harvard.edu/abs/1993ApJ...417...97H

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See detailMixmaster universe in fourth-order gravity theories
Cotsakis, S.; Demaret, Jacques; De Rop, Yves ULg et al

in Physical Review. D : Particles and Fields (1993), 48

We analyze the behavior of the Bianchi type-IX cosmological model in the full fourth-order theory of gravity in four space-time dimensions on approach to the singularity both analytically and numerically ... [more ▼]

We analyze the behavior of the Bianchi type-IX cosmological model in the full fourth-order theory of gravity in four space-time dimensions on approach to the singularity both analytically and numerically. By directly analyzing the full fourth-order field equations we prove explicitly that the Belinski-Khalatnikov-Lifshitz (BKL) analytic solution (and the accompanying bounce law) is also a solution to the more general case that we consider. But it appears to be nongeneric, because a perturbation analysis shows that power-law Kasner asymptotes are unstable on approach to the singularity. On the other hand, we find that the model possesses a stable isotropic monotonic power-law asymptotic solution and accordingly we show that there is a general solution which is nonchaotic near the space-time singularity. Numerical experiments confirm the existence of such a behavior. The inclusion of matter fields does not alter the evolution in the neighborhood of the singularity. The role of space-time dimensionality on the chaotic evolution of the mixmaster universe in these theories is also spelled out. In particular, we show that it is impossible to build a mixmaster universe in space-time dimensions higher than four in the full fourth-order gravity theory based on the BKL approximation scheme. [less ▲]

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See detailPhysiologie de la femme enceinte et facteurs de risques
Foidart, Jean-Michel ULg

in Contraception, Fertilite, Sexualité (1992) (1993), 21(11), 811-5

Physiological adaptations of the pregnant woman involve the circulatory, respiratory, digestive, renal, endocrine and metabolic systems. Their precise knowledge allows the clinician to verify the quality ... [more ▼]

Physiological adaptations of the pregnant woman involve the circulatory, respiratory, digestive, renal, endocrine and metabolic systems. Their precise knowledge allows the clinician to verify the quality of the adaptation of the pregnant woman and to avoid unnecessary treatment of physiological changes misconsidered as pathological changes in reference to prepregnancy standards. [less ▲]

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See detailUse of G.I.S. and remote sensing in hydrological model for impact study of land cover change in a malagasy rural basin
Randriamaherisoa, Alain; Binard, Marc ULg; Persoons, Etienne

in International Journal "Advances in Remote Sensing" (1993), 2(3), 154-164

A conceptual distributed-based model has been developed for flood simulation and forecasting. The model structure consists of a square grid network, in analogy with the raster form of numerical maps. The ... [more ▼]

A conceptual distributed-based model has been developed for flood simulation and forecasting. The model structure consists of a square grid network, in analogy with the raster form of numerical maps. The square-pixel is the analysis unit for hydrologie balance in relation with physi-cal characteristics. Punctual and cartographical data sources are used to characterize each mesh. Aerial photo-graphy and satellite imagery give information about land use. Topographical characteristics are obtained from Digi-tal Terrain Model (DTM). Soil type can be numerized to help in estimating the drainage condition. Hydrological data are distributed in accordance with the Thiessen's polygons or the associated sub-basin. All the data are handled by the GIS part in order to classify the surface runoff potential of all meshes. This procedure allow to consider the physical characteristics and the spatial vari-ability of the parameters at small scale, to manage special devices like storm basins, pumping stations and spillways and to do a quick study of the spatio-temporal evolution of the characteristics. Impact analysis of land cover modi-fications on the river flow regime is therefore possible. In one large rural Malagasy watershed, rince the 1960's, several waterworks were achieved in order to struggle against the flooding of the upstream fertile plain (subject of various developments). Meanwhile, the forest of the basin hillslopes was and still strongly claimed for pluvial rice crop, which is necessary for the subsistence of a fast growing population. The main object of this work is to study the hydrological impacts of these changes of land use on the watershed behaviour and to forecast the basin water regime evolution. [less ▲]

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See detailAcute Suppression of Gonadotropin-Releasing Hormone Secretion by Insulin-Like Growth Factor I and Subproducts: An Age-Dependent Endocrine Effect
Bourguignon, Jean-Pierre ULg; Gerard, Arlette ULg; Alvarez Gonzalez, Maria-Luz ULg et al

in Neuroendocrinology (1993), 58(5), 525-30

Using rat hypothalamic explants, we showed previously that activation of N-methyl-D-aspartate (NMDA) receptors was involved in the mechanism of gonadotropin-releasing hormone (GnRH) secretion. (1-3 ... [more ▼]

Using rat hypothalamic explants, we showed previously that activation of N-methyl-D-aspartate (NMDA) receptors was involved in the mechanism of gonadotropin-releasing hormone (GnRH) secretion. (1-3)Insulin-like growth factor I (IGF-I), the N-terminal tripeptide of IGF-I, was suggested to be a possible antagonist at NMDA receptors. Here, we study the effects of IGF-I and its subproducts, (1-3)IGF-I and (4-70)IGF-I, either given in vivo as a single subcutaneous injection or used in vitro, on the secretion of GnRH by hypothalamic explants. At the three ages studied (15, 25 and 50 days), (4-70)IGF-I does not show any effect. At 50 days, the in vivo administration or the in vitro use of IGF-I results in a dose-related inhibition of the GnRH secretion induced by veratridine, a depolarizing agent. In addition, the spontaneous pulsatile secretion of GnRH in vitro is transiently suppressed after the in vivo administration of IGF-I. (1-3)IGF-I results in an inhibitory effect similar to that of IGF-I. At 25 days, IGF-I and (1-3)IGF-I show the same effects as at 50 days though higher concentrations are required. At 15 days, IGF-I does not show any effect whereas a potent inhibition of GnRH secretion is observed using (1-3)IGF-I either in vivo or in vitro. At all ages, the effects of (1-3)IGF-I parallel those of AP-5, a competitive antagonist at NMDA receptors.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailAdjuvant postoperative accelerated hyperfractionated radiotherapy in rectal cancer : a feasability study
Coucke, Philippe ULg; Cuttat, J-F; Mirimanoff, R-O

in International Journal of Radiation, Oncology, Biology, Physics (1993), 24(4), 885-889

To assess the acute toxicity and hence feasibility of postoperative hyperfractionated accelerated radiotherapy in rectal cancer. METHODS AND MATERIALS: Twenty patients were submitted to accelerated ... [more ▼]

To assess the acute toxicity and hence feasibility of postoperative hyperfractionated accelerated radiotherapy in rectal cancer. METHODS AND MATERIALS: Twenty patients were submitted to accelerated hyperfractionated radiotherapy after resection of rectal cancer. A total dose of 48 Gy was given in 3 weeks. Two fractions of 1.6 Gy were used with a mean interfraction interval of at least 6 hours. The pelvic volume was treated by a four-field box technique using a linear accelerator (6-18 MV). Acute toxicity was assessed once per week. Small bowel and skin toxicity were scored according to the criteria of the World Health Organization. Bladder toxicity was scored according to the criteria of the Radiation Therapy Oncology Group. RESULTS: All the patients underwent the treatment as planned except one. No patient presented grade 3 or 4 bladder toxicity. There was only one patient who complained from grade 3 skin toxicity at the end of the treatment. Fourteen patients had some degree of intestinal toxicity. This was the most frequently occurring acute side-effect. Only two out of the fourteen patients had intestinal toxicity exceeding grade 2. CONCLUSION: Hyperfractionated accelerated radiotherapy on a pelvic volume is feasible [less ▲]

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See detailControl of Pulsatile Secretion of Gonadotrophin Releasing Hormone from Hypothalamic Explants
Bourguignon, Jean-Pierre ULg; Gerard, Arlette ULg; Alvarez Gonzalez, Maria-Luz ULg et al

in Human Reproduction (1993), 8 Suppl 2(NULL), 18-22

We have studied the secretion of gonadotrophin releasing hormone (GnRH) from hypothalamic explants of male rats at different ages in an attempt to delineate the neuroendocrine mechanism of the onset of ... [more ▼]

We have studied the secretion of gonadotrophin releasing hormone (GnRH) from hypothalamic explants of male rats at different ages in an attempt to delineate the neuroendocrine mechanism of the onset of puberty. In this paper, we review some of our recent studies and we provide evidence of a dual control played by receptors to neuroexcitatory amino acids. We showed previously that isolated explants of rat hypothalamus could secrete GnRH in a pulsatile manner. The onset of puberty was characterized by a 2-fold increase in frequency of GnRH secretory pulses. This reduction of the interval between GnRH pulses involved an inhibitory autofeedback effect of GnRH on the pulse generator which was shut off following a secretory episode. This period of refractoriness was longer before puberty than after the onset of puberty. Activation of receptors to neuroexcitatory amino acids (N-methyl-D-aspartate; NMDA-type) was involved in the mechanism of pulsatile GnRH secretion. Striking developmental changes in NMDA-receptor-mediated GnRH secretion were demonstrated with a maximal activity around the time of the onset of puberty. Similar changes occurred in orchidectomized animals, indicating that this maturational process was gonad-independent. While evidence accumulated that NMDA receptors were involved in a stimulatory control of GnRH secretion, we found that NMDA receptors mediated an inhibitory effect on GnRH secretion. This inhibitory effect was very potent in the immature hypothalamus and it showed a marked reduction in potency before onset of puberty.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailTowards a rational utilization of satellite imagery for Lisbon's metropolitan planning
Binard, Marc ULg; Nadasdi, Istvan

in EARSeL International Journal "ADVANCES IN REMOTE SENSING" (1993), 2(3), 130-137

The knowledge of the actual structure and 'intensity of land cover is a fundamental information for the urban planning. Some aspects of the seeked information can be extracted from satellite imagery. This ... [more ▼]

The knowledge of the actual structure and 'intensity of land cover is a fundamental information for the urban planning. Some aspects of the seeked information can be extracted from satellite imagery. This presentation gives some exemples over the Metropolitan area of Lisbon. First, an image segmentation is accomplished over an XS3 band. This process leads to a rather valid subdivision of the region in morphological units. Secondly, the urban and vegetal categories, issued from a land cover classification, are modeled in the form of statistical surfaces. The statistical surfaces take advantage of the analytical power of a raster solving approach. Fi-nally, the urban and vegetal intensity surfaces are merged. The result can be considered as an attempt of ecozoning the considered region. The paper discuss also the possibilities of using remotly sensed data for urban planning. [less ▲]

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See detailBenign Prostatic Hyperplasia and Normal Prostate Aging: Differences in Types I and Ii 5 Alpha-Reductase and Steroid Hormone Receptor Messenger Ribonucleic Acid (Mrna) Levels, but Not in Insulin-Like Growth Factor Mrna Levels
Bonnet, Pierre ULg; Reiter, E.; Bruyninx, M. et al

in Journal of Clinical Endocrinology and Metabolism (The) (1993), 77(5), 1203-8

Benign prostatic hyperplasia (BPH) is so common in elderly men that the development of adenomatous nodules in this organ can be seen as a normal age-dependent process. In this work, we used Northern ... [more ▼]

Benign prostatic hyperplasia (BPH) is so common in elderly men that the development of adenomatous nodules in this organ can be seen as a normal age-dependent process. In this work, we used Northern blotting to compare the levels of androgen, estrogen, and insulin-like growth factor-I (IGF-I) receptor in young (age range, 23-33; n = 3), old normal (age range, 52-80; n = 3), and BPH-affected subjects (age range, 66-87; n = 15). We have also investigated in these groups the expression of genes coding for the two 5 alpha-reductases (types I and II), aromatase, IGF-I, and IGF-II. Our results show significantly increased levels of IGF mRNA in old healthy and BPH-affected subjects; the respective rises for IGF-I, IGF-II, and IGF-I receptor mRNAs were 3.0-, 2.9-, and 1.5-fold (BPH) and 2.7-, 2.4-, and 1.8-fold (old normal controls). For estrogen receptor, androgen receptor, and type I and II 5 alpha-reductase mRNAs, a marked but opposite effect was observed in adenomatous tissues only; the respective levels were 2.2-, 1.8-, 3.9-, and 1.7-fold lower than those in young adult subjects, whereas no significant differences were recorded between the two normal groups. Morphometric analysis of each tissue specimen confirmed the significantly lower epithelium/stroma ratio in adenomas compared to young or old healthy tissues. Together, these observations suggest that prostatic adenomas may result from at least two conjugate processes: one characterized by a drop in the mRNA levels of steroid hormone receptors, which might be associated with a lower epithelium/stroma ratio, and another characterized by normal aging phenomena, of which the increased production of IGFs and IGF-I receptor transcripts could be biochemical markers. [less ▲]

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See detailEnhancement of Tumorigenicity of Human Breast Adenocarcinoma Cells in Nude Mice by Matrigel and Fibroblasts
Noël, Agnès ULg; Gillet, Marie-Claire ULg; Purnell, G. et al

in British Journal of Cancer (1993), 68(5), 909-15

The failure of MCF7 cells to induce the formation of tumours after sub-cutaneous inoculation into athymic nude mice can be obviated by the simultaneous injection of an extract of basement membrane ... [more ▼]

The failure of MCF7 cells to induce the formation of tumours after sub-cutaneous inoculation into athymic nude mice can be obviated by the simultaneous injection of an extract of basement membrane proteins (matrigel). Tumour growth is promoted and the latency period is low (2 to 4 weeks). In the absence of matrigel, the simultaneous inoculation of fibroblasts and MCF7 cells also resulted in the development of tumours, but with a longer latency period (about 2 months). The tumorigenic synergy between matrigel and fibroblasts was evidenced by co-inoculating MCF7 cells MDA-MB 231 cells with fibroblasts and matrigel. This co-inoculation decreased the delay of appearance of the tumours and/or accelerated the tumour growth, depending upon the number of fibroblasts injected. Repeated injections of fibroblasts conditioned medium, at the site of inoculum of tumour cells also enhanced tumour growth, suggesting the involvement of soluble factors secreted by fibroblasts. Histologically, tumours induced by co-inoculation of tumour cells and fibroblasts contained more stromal structures including vimentin-positive cells, fibronectin and interstitial collagens. These data suggest that human tumours may be reconstituted and grown in athymic nude mice using basement membrane components and fibroblasts as inductors. [less ▲]

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See detailAnionic polymerization of (meth)acrylic monomers. 12. Efect of lithium chloride on the stereochemistry on the anionic polymerization of methyl methacrylate in THF and in a 9/1 toluene/THF mixture
Wang, Jin-Shan; Jérôme, Robert ULg; Warin, Roger et al

in Macromolecules (1993), 26(22), 5984-5990

The effect of LiCl on the stereochemistry of the anionic polymerization of methyl methacrylate in the presence of a lithium counterion at -78-degrees-C in THF and in a 9/1 toluene/THF mixture, has been ... [more ▼]

The effect of LiCl on the stereochemistry of the anionic polymerization of methyl methacrylate in the presence of a lithium counterion at -78-degrees-C in THF and in a 9/1 toluene/THF mixture, has been studied by C-13 and H-1 NMR spectroscopy. It has been found that LiCl has an important effect on the E/Z ratio of the living chain ends in THF, in contrast to the main-chain tacticity. In contrast, LiCl has a significant influence on the stereoregularity of the anionic polymerization of MMA in a 9/1 toluene/THF mixture. When the LiCl/initiator molar ratio is increased, the syndiotactic placements (rr) are favored at the expense of the isotactic ones (mm). This effect can be accounted for by a multistate propagating mechanism controlled by association/complexation equilibria among associated, nonassociated, and LiCl-complexed species. These association/complexation equilbria, which were originally proposed by Muller, appear to have a decisive effect not only on the livingness (molecular weight distribution (MWD)) but also on the stereochemistry of the anionic polymerization of MMA in a 9/1 toluene/THF mixture at -78-degrees-C, confirming the involvement of the ligand in propagation control. [less ▲]

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See detailInteractions between Active-Site Serine Beta-Lactamases and So-Called Beta-Lactamase-Stable Antibiotics. Kinetic and Molecular Modelling Studies
Matagne, André ULg; Lamotte-Brasseur, J.; Frère, Jean-Marie ULg

in European Journal of Biochemistry (1993), 217(1), 61-67

The interactions between imipenem and four monobactams and three class A beta-lactamases have been studied in detail. Despite their reputation as being beta-lactamase-stable, some of these compounds were ... [more ▼]

The interactions between imipenem and four monobactams and three class A beta-lactamases have been studied in detail. Despite their reputation as being beta-lactamase-stable, some of these compounds were significantly hydrolysed by the enzymes. The results obtained with the Streptomyces albus G beta-lactamase have been analysed in the light of molecular modelling studies. The discussion is extended to include other so-called beta-lactamase-stable antibiotics to demonstrate that this appellation can often be misleading. [less ▲]

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See detailMorphology and time variation of the Jovian Far UV aurora: Hubble Space Telescope observations
Gérard, Jean-Claude ULg; Dols, Vincent; Paresce, Francesco et al

in Journal of Geophysical Research (1993), 98

High spatial resolution images of the north polar region of Jupiter have been obtained with the Faint Object Camera (FOC) on board the Hubble Space Telescope (HST). The first set of two images collected ... [more ▼]

High spatial resolution images of the north polar region of Jupiter have been obtained with the Faint Object Camera (FOC) on board the Hubble Space Telescope (HST). The first set of two images collected 87 min apart in February 1992 shows a bright (approximately or equal to 180 kR) emission superimposed on the background in rotation with the planet. Both Ly alpha images show common regions of enhanced emission but differences are also observed, possibly due to temporal variations. The second group of images obtained on June 23 and 26, 1992 isolates a spectral region near 153 nm dominated by the H2 Lyman bands and continuum. Both pictures exhibit a narrow arc structure fitting the L = 30 magnetotail field line footprint in the morning sector and a broader diffuse aurora in the afternoon. They show no indication of an evening twilight enhancement. Although the central meridian longitudes were similar, significant differences are seen in the two exposures, especially in the region of diffuse emission, and interpreted as signatures of temporal variations. The total power radiated in the H2 bands is approximately or equal to 2 x 10[SUP]12[/SUP] W, in agreement with previous UV spectrometer observations. The high local H2 emission rates (approximately 450 kR) imply a particle precipitation carrying an energy flux of about 5 x 10[SUP]-2[/SUP] W/sq m. [less ▲]

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See detailSubtotal aplasia of myelinated nerve fibers in the sural nerve.
Schroder, J. M.; Heide, G.; RAMAEKERS, Vincent ULg et al

in Neuropediatrics (1993), 24(5), 286-91

Thus far, only very few cases with neuronal maldevelopment in the peripheral nervous system have been reported (Table 1). The present sporadic case manifested itself with peripheral sensorimotor ... [more ▼]

Thus far, only very few cases with neuronal maldevelopment in the peripheral nervous system have been reported (Table 1). The present sporadic case manifested itself with peripheral sensorimotor polyneuropathy in early infancy. Clinical findings included pareses and hypaesthesia of distal extremities and severely reduced nerve conduction velocities. During adolescence, cerebellar ataxia developed. Sural nerve biopsy taken at the age of 14.5 years showed severe fascicular hypoplasia, aplasia of large myelinated nerve fibers, and subtotal deficiency of small myelinated nerve fibers without numerical reduction of unmyelinated axons. There was no structural evidence of a progression of myelinated fiber breakdown although some collagen pockets and empty Schwann cell processes among preserved unmyelinated axons indicated some loss of unmyelinated fibers. These findings are interpreted as representing maldevelopment of the myelinated fibers in the peripheral nervous system. Appropriate classification of this unique disease among the known developmental disorders of peripheral nerves is discussed. [less ▲]

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See detailHyperfunctioning unilateral adrenal macronodule in three patients with Cushing's disease: hormonal and imaging characterization.
Abs, R.; Nobels, F.; Verhelst, J. et al

in Acta Endocrinologica (1993), 129(4), 284-90

We aimed to investigate the dynamics of adrenocorticotropin (ACTH) and cortisol secretion in pituitary-dependent Cushing's syndrome with bilateral macronodular adrenal hyperplasia presenting as a single ... [more ▼]

We aimed to investigate the dynamics of adrenocorticotropin (ACTH) and cortisol secretion in pituitary-dependent Cushing's syndrome with bilateral macronodular adrenal hyperplasia presenting as a single adrenal macronodule, and to determine the imaging characteristics of this syndrome. Three female patients were studied. Plasma ACTH and serum cortisol secretion were studied by determining their rhythmicity and pulsatility and their responses to the administration of ovine corticotropin-releasing factor, thyrotropin-releasing hormone, metyrapone, tetracosactrin, insulin and dexamethasone. Techniques used to localize the anatomical lesion were bilateral simultaneous inferior petrosal sinus sampling, magnetic resonance examination of the pituitary, computed tomography (CT) scanning and [75Se]cholesterol scintigraphy of the adrenal glands. Plasma ACTH and serum cortisol levels were measured using a commercial radioimmunoassay and an immunoradiometric assay. The ACTH and cortisol pulse number and amplitude were calculated using established computer software. In all three patients ACTH and cortisol secretory dynamics fulfilled the requirements for diagnosis of pituitary-dependent Cushing's syndrome. A close relationship between ACTH and cortisol pulses also favored a pituitary dependency. Study of the amplitude of cortisol pulses classified two patients in the group of hypopulsatile Cushing's disease. Adrenal CT scanning demonstrated the presence of a large single nodule. [75Se]Cholesterol scintigraphy showed bilateral radionuclide uptake, although mostly localized over the adrenal nodule. All patients underwent successful trans-sphenoidal hypophysectomy. Over a period of 1 year, a slow shrinkage of the adrenal nodule was observed in two patients, while no change in volume was observed in one patient.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailCerebral hyperperfusion following episodes of bradycardia in the preterm infant
RAMAEKERS, Vincent ULg; Casaer, P.; Daniels, H.

in Early human development (1993), 34(3), 199-208

The alterations in cerebral hemodynamics during and following 39 episodes with bradycardia of different severity have been studied by analysis of Doppler flow velocity waveforms amongst 16 stable preterm ... [more ▼]

The alterations in cerebral hemodynamics during and following 39 episodes with bradycardia of different severity have been studied by analysis of Doppler flow velocity waveforms amongst 16 stable preterm infants (range of conceptional age at the time of study 33-39 weeks; weight 1730-2820 g). Each episode with bradycardia has been classified as mild on seven occasions (heart rate between 100-120 beats/min), moderate on 15 occasions (80-100), or severe on 17 occasions (heart rate below 80) Depending on the severity of the bradycardia, the time-averaged mean flow velocity (V) could decrease by 80% below the preexistent baseline value and the end-diastolic velocity (D) dropped towards the zero line, whereas peak systolic velocities did not change The magnitude of the percentage decrease of V correlated positively with the severity of bradycardia, indicating a progressive decline of cerebral blood flow (CBF). Following bradycardia, V could increase up to 75% above the preexistent baseline value. Simultaneously, an increase of mean arterial blood pressure and D could be documented. Peak systolic velocities remained unaltered. The magnitude of the percentage increase of V following bradycardia depended both on the severity of bradycardia as well as on the drop in transcutaneous oxygen during the preceding bradycardia. Interpretation of these findings suggested that the transient cerebral hyperperfusion following bradycardia compensates for the hypoxic-ischemic episode, sustained during the preceding epoch of apnea and bradycardia. [less ▲]

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See detailExtensive Deposition of Basement Membrane by Tumours: A Prognostic Factor? A Reappraisal
Noël, Agnès ULg; Fontes, R.; Emonard, H. et al

in Epithelial Cell Biology (1993), 2(4), 150-4

A loss of the continuous linear deposit of basement membrane around invasive carcinomas has been suggested to correlate with their increased invasiveness. In contrast, extensive basement membrane ... [more ▼]

A loss of the continuous linear deposit of basement membrane around invasive carcinomas has been suggested to correlate with their increased invasiveness. In contrast, extensive basement membrane deposition would represent a more favourable prognosis. The Engelbreth-Holm-Swarm (EHS) tumour, a transplantable neoplasm, is widely used for its ability to synthesize and deposit large amounts of basement membrane components. We have evaluated the metastatic potential of this neoplasm 2 months after subcutaneous inoculation. Histological examination of lung sections revealed the presence of numerous metastatic foci. The metastatic cells retained their organization into clusters surrounded by extracellular matrix. Both the 72 kDa and the 92 kDa type IV collagenases were detected by zymography in Triton or urea extract (matrigel) of primary tumour. These results cast doubt on the hypothesis that the extensiveness of basement membrane deposition might always be of prognostic value by being inversely correlated with the degree of invasiveness of a carcinoma. [less ▲]

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See detailPlasma Histamine and Bronchial Reactivity in Allergic Asthma
Corhay, Jean-Louis ULg; Bury, Thierry ULg; Louis, Renaud ULg et al

in Allergy (1993), 48(7), 547-9

Histamine is an important mediator of allergic inflammation and bronchial hyperresponsiveness (BHR), a hallmark of asthma. Studies on the relationship between plasma histamine and BHR in allergic ... [more ▼]

Histamine is an important mediator of allergic inflammation and bronchial hyperresponsiveness (BHR), a hallmark of asthma. Studies on the relationship between plasma histamine and BHR in allergic asthmatic patients have yielded controversial results. We therefore measured plasma histamine and bronchial reactivity in 30 nonsmoker volunteers taking no medication. Eleven were normal subjects; 19 were stable, mildly allergic asthmatic patients. Venous blood was taken to measure blood cells and basal plasma histamine by radioimmunoassay. After blood sampling, all subjects underwent a measurement of PC20M (concentration of methacholine causing a 20% fall in FEV1). Mean plasma histamine levels were 0.21 +/- 0.1 ng/ml and 0.44 +/- 0.3 ng/ml in normal and asthmatic subjects, respectively (P < 0.05). We found a significant increase of blood eosinophils and basophils in asthmatic patients, and a positive correlation between plasma histamine and circulating basophils. PC20M was greater than 16 mg in normal volunteers, and mean PC20M was 2.1 +/- 2 mg/ml in asthmatic patients. PC20M did not correlate with plasma histamine levels, but it did so negatively with blood eosinophils. The increased plasma histamine concentration in mildly atopic asthmatic patients might be a consequence of the high basophil releasability of atopics and the higher basophil counts in allergic asthma. Plasma histamine is thus unlikely to be a determinant of BHR in asthma. [less ▲]

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See detailDevelopment of a combined mechanical and enzymatic method for the isolation of intact preantral follicles from fetal, calf and adult bovine ovaries
Figueiredo, José Ricardo; Hulshof, S. C. J.; Van den Hurk, R. et al

in Theriogenology (1993), 40(4), 789-799

The isolation of preantral follicles from the ovaries of bovine fetuses, calves and adult cows was performed using a simple, rapid mechanical and enzyme method. The ovaries were cut into small pieces with ... [more ▼]

The isolation of preantral follicles from the ovaries of bovine fetuses, calves and adult cows was performed using a simple, rapid mechanical and enzyme method. The ovaries were cut into small pieces with a tissue chopper. Then, the suspension was filtered successively through 500 and 100 μm nylon mesh filters. This simple mechanical procedure resulted in large numbers of isolated preantral follicles: 2,142 ± 254; 512 ± 92 and 298 ± 54 from the ovaries of bovine fetuses, calves and cows, respectively. In addition, the ovarian fragments between 100 and 500 μm were suspended in 10 ml of M199 Hepes medium plus 5% FCS and divided into 2 equal parts: one portion was used for collagenase treatment (200 U/ml) for 20 minutes, while the other served as a control. Collagenase treatment resulted in 841 ± 161; 216 ± 51 and 52 ± 17 preantral follicles from fetuses, calves and cows, respectively, compared with 312 ± 86; 52 ± 15 and 10 ± 2 in the control group. The use of collagenase with ovarian fragments selected by filtration as a method for increasing the rate of recovery of preantral follicles is described here. [less ▲]

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See detailEnd-attaching copolymer adsorption: kinetics and effects of chain architecture
Dogan, J. R.; Stamm, Manfred; Toprakcioglu, C. et al

in Macromolecules (1993), 26(20), 5321-5330

In this study we report on the adsorption behavior of end-attaching triblock and diblock copolymers. The triblock copolymers consist of relatively short PEO end blocks and a much longer PS middle block or ... [more ▼]

In this study we report on the adsorption behavior of end-attaching triblock and diblock copolymers. The triblock copolymers consist of relatively short PEO end blocks and a much longer PS middle block or, in one case, of zwitterionic end groups with a PS middle block. The diblock materials consist of a PEO block of fixed length and varying polystyrene lengths. A silicon wafer with an oxide layer is used as the surface, and adsorption takes place from toluene; only the end groups adsorb, leaving the polystyrene block dangling in solution. We find that diblock copolymers which range from symmetric to moderately symmetric obey the scaling law for the surface coverage which was proposed in the theory of Marques and Joanny (i.e., sigma is-proportional-to 1/N(A), where N(A) is the number of segments in the adsorbing block). However, we find that for triblock copolymers of comparable asymmetry the surface coverage scales according to the relationship sigma is-proportional-to 1/beta2, where beta is the ratio of the size of the nonadsorbing block to that of the adsorbing block. This implies that moderately symmetric triblock copolymers behave like highly asymmetric diblock copolymers; the adsorption behavior is dominated by the nonadsorbing block size. Our experiments demonstrate the observation of extremely long-lived nonequilibrium states. On the basis of these observations we propose a simplified version of a recent theory of adsorption which is capable of qualitatively describing much of the experimentally observed phenomena. [less ▲]

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See detailSurface composition of poly(styrene-d8-styrene) random copolymers studied by static secondary ion mass spectroscopy
Affrossman, S.; Hartshorne, M.; Jérôme, Robert ULg et al

in Macromolecules (1993), 26(20), 5400-5404

The surface compositions of a series of random copolymers of styrene and deuteriostyrene have been determined by SIMS. The mechanism of fragmentation during the SIMS process is examined, and the ... [more ▼]

The surface compositions of a series of random copolymers of styrene and deuteriostyrene have been determined by SIMS. The mechanism of fragmentation during the SIMS process is examined, and the contribution from naturally occurring isotopes is evaluated. The data are shown to fit a model of a completely random copolymer system if they are corrected for the effects of impurities introduced in the syntheses and for the contribution from C-13. [less ▲]

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See detailMonosomy 11q: Report of Two Familial Cases and Review of the Literature
Hustinx, Roland ULg; Verloes, Alain ULg; Grattagliano, B. et al

in American Journal of Medical Genetics (1993), 47(3), 312-7

We present four children from two families with the typical 11q- phenotype resulting from an unbalanced segregation of a parental translocation. In the first family, the father had a 46,XY,t(5;11)(q24;q23 ... [more ▼]

We present four children from two families with the typical 11q- phenotype resulting from an unbalanced segregation of a parental translocation. In the first family, the father had a 46,XY,t(5;11)(q24;q23.3) constitution. The father of the three other children had a 46,XY,t(11;17)(q23;p13) translocation. Despite associated partial deletion, three of the children had a typical 11q- phenotype. The fourth one, whose pregnancy was terminated in the second trimester, had a hypoplastic left heart but no other considered gross anomalies. A review of 36 previous cases, including 5 due to translocations (4 familial rearrangements, and 1 of unknown origin) is given with emphasis on the relationships between break-points and phenotype. Undescribed manifestations in our patients include agenesis of corpus callosum adactyly and malrotation of the gut. [less ▲]

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See detailErgospirométrie et pratique pneumologique
Bury, Thierry ULg; Corhay, Jean-Louis ULg; Louis, Renaud ULg et al

in Revue Médicale de Liège (1993), 48(9), 523-6

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See detailPrognosis of human chorionic gonadotropin-producing seminoma treated by postoperative radiotherapy
Mirimanoff, R-O; Sinzig, M; Krüger, M et al

in International Journal of Radiation, Oncology, Biology, Physics (1993), 27(1), 17-24

To clarify the controversy about the management and prognosis of human chorionic gonadotropin-producing seminoma, the records of 132 patients with abnormal human chorionic gonadotropin values treated with ... [more ▼]

To clarify the controversy about the management and prognosis of human chorionic gonadotropin-producing seminoma, the records of 132 patients with abnormal human chorionic gonadotropin values treated with radiotherapy were analyzed. METHODS AND MATERIALS: The records of 1169 patients with pure seminoma treated in 10 institutions were screened for serum or urinary human chorionic gonadotropin. One hundred and thirty two patients with elevated human chorionic gonadotropin were found: 96 Stage I, 20 IIA, 7 IIB, 8 III and 1 IV. Median age was 34 y., mean follow-up was 5.0 years [range 1-12 y]. All received infradiaphragmatic radiotherapy (median dose 30 Gy), 25 (2 Stage I, 11 IIA, 5 IIB and 7 III) supradiaphragmatic radiotherapy (median dose: 28.5 Gy) and 10 had also initial chemotherapy (3 Stage IIB 6 III and 1 IV). Patients were allocated to three groups according to human chorionic gonadotropin values: (a) moderate elevation: up to 10 times (104 pts), (b) high elevation: 10 to 100 times (20 pts), (c) very high elevation: over 100 times the upper limit of normal value (8 pts). RESULTS: The proportion of Stage I, II and III was 76%, 19%, 5% in the ME group versus 50%, 35%, 15% in the high elevation group (p < 0.05). In the very high elevation group there were 7 Stage I and 1 Stage IV. Of 132 patients, six died (three dead of disease, two suicides, one acquired immunodeficiency syndrome). The 5 years overall survival probability was 94%. There were seven recurrences (initial stage: 1 Stage I, 2 IIB, 3 III and 1 IV). Of these, there were one in-field recurrence, 3 out of field and 3 in both sites. In 5 of 7, the human chorionic gonadotrophin level was again elevated at recurrence. The 5 years recurrence-free-survival probability was 94% (98% for Stage I, 100% for Stage IIA and 65% for Stage IIB and III [p < 0.001 between I and IIB + III, p < 0.05 between IIA and IIB + III]). Four of the 7 recurrences were salvaged by chimiotherapy +/- radiotherapy. In the high elevation and very high elevation groups, the 5 years recurrence-free-survival was 88%, vs. 96% for the moderate elevation group (p = 0.10). CONCLUSION: Based on this series of patients, human chorionic gonadotropin production is not an unfavorable prognostic factor in pure seminoma. Even in the subgroups with high or very high human chorionic gonadotropin levels (who had a higher proportion of advanced stages), the prognosis remained excellent. In Stage I and IIA seminoma with abnormal human chorionic gonadotropin levels, recurrence rate after post-operative radiotherapy alone is extremely low. [less ▲]

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See detailOn the linearity of ESO CCD#9 at CAT+CES.
Gosset, Eric ULg; Magain, Pierre ULg

in The Messenger (1993), 73

Not Available

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See detailAttachment of the Gammaherpesvirus Bovine Herpesvirus 4 Is Mediated by the Interaction of Gp8 Glycoprotein with Heparinlike Moieties on the Cell Surface
Vanderplasschen, Alain ULg; Bublot, M.; Dubuisson, J. et al

in Virology (1993), 196(1), 232-40

Cell surface heparan sulfate serves as the initial receptor for several alphaherpesviruses and at least one betaherpesvirus. This study shows that during the process of adsorption of the gammaherpesvirus ... [more ▼]

Cell surface heparan sulfate serves as the initial receptor for several alphaherpesviruses and at least one betaherpesvirus. This study shows that during the process of adsorption of the gammaherpesvirus bovine herpesvirus 4 (BHV-4), the viral glycoprotein gp8 interacts with heparinlike moieties of cell surface. This conclusion is based on the following findings. (i) Soluble heparin was capable of blocking BHV-4 infection of Georgia bovine kidney cells by inhibition of viral attachment. (ii) Nevertheless, after virus adsorption to Georgia bovine kidney cells, heparin was partially capable of removing adsorbed virus. (iii) Enzymatic digestion of cell surface heparan sulfate but not of chondroitin sulfates A, B, and C reduced the binding of the virus to the cells, and rendered the cells partially resistant to infection. (iv) Radiolabeled purified BHV-4 bound to wild-type Chinese hamster ovary cells, whereas binding of the virus to mutant Chinese hamster ovary cell lines that where deficient in either all glycosaminoglycans or only heparan sulfate was significantly impaired. (v) Using heparin-affinity chromatography, gp8 glycoprotein was shown to bind specifically to immobilized heparin and to elute in the presence of soluble heparin. These data together showed that the gammaherpesvirus BHV-4, like alphaherpesviruses and one betaherpesvirus, adsorbs to cells by binding to cell surface heparin-like moieties. Therefore, this study extends the group of herpesviruses interacting with heparinlike moieties at the cell surface to a member of the gammaherpesvirinae subfamily. [less ▲]

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See detailAcute Biochemical Variations Induced by Four Different Calcium Salts in Healthy Male Volunteers
Reginster, Jean-Yves ULg; Denis, D.; Bartsch, Valérie ULg et al

in Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis & the National Osteoporosis Foundation of the USA (1993), 3

Calcium (Ca) supplements have positive effects in growing children, reduce bone loss in late-postmenopausal women with a low calcium diet and, in association with vitamin D3 supplements, may reduce non ... [more ▼]

Calcium (Ca) supplements have positive effects in growing children, reduce bone loss in late-postmenopausal women with a low calcium diet and, in association with vitamin D3 supplements, may reduce non-vertebral fracture rates in elderly women. However, for many formulated pharmaceutical products their relative beneficial effects have not been conclusively established. We have compared the acute (6 h) metabolic responses following oral administration of two preparations of calcium gluconolactate and carbonate (CG and CG'), tricalcium phosphate (TCP) and calcium citrate (CC), given on separate occasions in each of 10 healthy young male volunteers. The subjects fasted overnight for 12 h and continued to fast during the experimental procedure. A 1000 mg dose of each Ca salt was ingested at weekly intervals. Blood was drawn after 30, 60, 90, 120, 180, 240, 300 and 360 min for measurement of serum Ca, phosphorus (P), parathyroid hormone (PTH) and whole plasma calcitonin (iCT). All Ca supplements induced significant (+6.4% to +8.1%; p < 0.01) increases in Ca and significant suppression of PTH (-37.4% to -57.4%; p < 0.01). Comparison of response curves revealed significantly (p < 0.01) more marked Ca increase and PTH suppression with CC than with the other three Ca salts. CG' and CC induced marginal decreases in serum P and the overall curve of P variations was different for TCP compared with CG, CG' and CC. No significant variation of iCT was recorded during the test.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailPrevention of Osteoporosis with Nasal Salmon Calcitonin: Effect of Anti-Salmon Calcitonin Antibody Formation
Reginster, Jean-Yves ULg; Gaspar, S; Deroisy, Rita ULg et al

in Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis & the National Osteoporosis Foundation of the USA (1993), 3

The amino acid sequence of salmon calcitonin (SCT) differs considerably from that of the human hormone and specific antibodies (Ab) develop in a significant proportion of patients after parenteral or ... [more ▼]

The amino acid sequence of salmon calcitonin (SCT) differs considerably from that of the human hormone and specific antibodies (Ab) develop in a significant proportion of patients after parenteral or nasal administration of SCT. Controversy remains regarding the functional importance of these Ab. We report on the development of specific anti-SCT Ab in a population of postmenopausal women receiving nasal SCT for prevention of postmenopausal bone loss, and compare the effects of nasal SCT in women with or without Ab. Thirty-nine per cent of women developed Ab after 6 months of treatment with SCT, 52% after 12 months, and 61% after 18 and 24 months. After 24 months the AB titre was 3.47-17.7 x 10(-9) M/l (mean +/- SD: 13.3 +/- 3.1 x 10(-9) M/l). No significant differences appeared between the changes in lumbar bone mineral density (BMD) measured in the whole population (n = 44) (mean +/- SD: +1.06 +/- 3.9%), the patients without Ab (n = 17) (+0.05 +/- 3.7%) or in those with Ab (n = 27) (+1.7 +/- 4.6%). During the same period, a control population randomly assigned to a 500 mg/day calcium intake showed a significant loss of lumbar BMD (-4.57 +/- 4.9%) (p < 0.01). In conclusion, in healthy postmenopausal women nasal SCT seems to maintain the same preventive effect against bone loss whether or not Ab are present. [less ▲]

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See detailEvidence for Free Radical Formation During Human Kidney Transplantation
Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg; Franssen, Christine ULg et al

in Free Radical Biology & Medicine (1993), 15(3), 343-8

Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of ... [more ▼]

Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of myeloperoxidase (a marker of neutrophil activation) in the systemic blood. Early (2 min) and late revascularization (30 min) of the kidney were respectively associated with a significant decrease of 35.5 and 40% of the initial level of plasma vitamin E. This consumption paralleled to the decrease of the vitamin E/total lipids ratio, a better indicator of vitamin E status. Heparin administration preceding renal artery clamping resulted in a twofold significant increase of baseline plasma myeloperoxidase (MPO) level (523 +/- 214 ng/ml). At kidney reperfusion, MPO concentration rose again and reached a maximum value of 1,653 +/- 882 ng/ml, indicating the presence of considerable neutrophil activation. A return to the baseline value was observed after 30 min of reperfusion. A short discussion about the possible origin of this MPO increase is given. Taken together, these data strongly suggest that free radical production, leading to lipid peroxidation phenomena, can occur within the early phase of kidney revascularization. Preliminary data using electron spin resonance with the spin-trapping technique strengthen this hypothesis. [less ▲]

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See detailStability of a FBTCS Scheme Applied to the Propagation of Shallow-Water Inertia-Gravity Waves on Various Space Grids
Beckers, Jean-Marie ULg; Deleersnijder, Eric

in Journal of Computational Physics (1993), 108(1), 94-104

The equations governing the propagation of inertia-gravity waves in geophysical fluid flows are discretized on the A, B, C, and D grids according to the classical forward-backward on time and centered on ... [more ▼]

The equations governing the propagation of inertia-gravity waves in geophysical fluid flows are discretized on the A, B, C, and D grids according to the classical forward-backward on time and centered on space (FBTCS) numerical scheme. The von Neumann stability analysis is performed and it is shown that the stability condition of the inertia-gravity waves scheme is more restrictive, at least by a factor of , than that concerning pure gravity waves, whatever the magnitude of the Coriolis parameter. Finally, the general necessary and sufficient stability condition is derived for the A, B and C grids, while, on the D grid, the stability condition has been obtained only in particular cases. [less ▲]

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See detailSous le swing de la croix
Sacré, Robert ULg

in Soul Bag (1993), (132), 12-16

Des Hymnes aux Negro Spirituals et aux Gospel Songs

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See detailNo Increase in Plasma Histamine During Paf-Induced Airway Obstruction in Allergic Asthmatics
Louis, Renaud ULg; Bury, Thierry ULg; Corhay, Jean-Louis ULg et al

in CHEST (1993), 104(3), 806-10

To investigate the possible role of mast cell or basophil histamine release in mediating platelet-activating factor (PAF) airway obstruction, we studied the effect of inhaled PAF (30 micrograms, single ... [more ▼]

To investigate the possible role of mast cell or basophil histamine release in mediating platelet-activating factor (PAF) airway obstruction, we studied the effect of inhaled PAF (30 micrograms, single dose) on plasma histamine, bronchial caliber, and leukocyte and platelet counts in six patients with mild or moderate allergic asthma (mean age, 27 +/- 1.3 years; mean FEV1, 95 +/- 5 percent of predicted; mean PC20 methacholine, 1.46 +/- 0.36 mg/ml). Specific conductance (SGaw) FEV1, FEF25-75 percent, differential leukocyte and platelet counts, and plasma histamine (radioimmunoassay) were measured before and 5, 10, 15, and 20 min after PAF inhalation. Mean basal plasma histamine level was 0.28 +/- 0.04 ng/ml. Inhalation of PAF caused a fall in SGaw peaking at 5 min (43 +/- 9 percent) and a fall in FEV1 and FEF25-75 peaking at 10 min (19 +/- 10 percent and 30 +/- 13 percent, respectively). There was also a rapid and transient fall in circulating neutrophils at 5 min (from 3,096 +/- 204/mm3 to 2,551 +/- 158/mm3, p < 0.05) followed by a rebound neutrophilia. In contrast, plasma histamine level did not change significantly at any time measured. Conversely in the same asthmatics, a rapid rise in plasma histamine level (from 0.29 +/- 0.03 ng/ml at baseline to 0.53 +/- 0.06 ng/ml at 5 min; p < 0.01) was observed after an allergenic challenge (Dermatophagoides pteronyssinus) causing a fall in FEV1 peaking at 10 min (22 +/- 4 percent). Thus, inhaled PAF may induce airway obstruction and neutropenia in asthmatics without any significant change of plasma histamine level. These results indicate that it is unlikely that lung mast cells or basophils degranulate during PAF-induced bronchoconstriction. [less ▲]

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See detailMacromolecular engineering of polylactones and polylactides. 12. Study of the depolymerizatin reactions of poly(ε-caprolactone with functional aluminum alkoxide end groups
Dubois, Philippe; Barakat, Ibrahim; Jérôme, Robert ULg et al

in Macromolecules (1993), 26(17), 4407-4412

Ring-opening polymerization of epsilon-caprolactone has been initiated with functional aluminum alkoxides in toluene at 25-degrees-C. Degradation of ''living'' polyester chains by transesterification ... [more ▼]

Ring-opening polymerization of epsilon-caprolactone has been initiated with functional aluminum alkoxides in toluene at 25-degrees-C. Degradation of ''living'' polyester chains by transesterification reactions has been studied in relation to temperature, solvent polarity, average molecular weight, and structure of the initiator, i.e., the nature of the functional group and the number of alkoxides per Al atom. Degradation products, particularly cyclic oligomers, have been isolated by supercritical fluid extraction (SFE) and characterized by GC-MS. The effect of Lewis bases on transesterification reactions has been investigated and discussed in reference to the ''coordination-insertion'' mechanism. [less ▲]

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See detailLa mainmise administrative sur les systèmes d'information hospitaliers
Albert, Adelin ULg

in Revue Médicale de Liège (1993), 48(8), 465-72

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See detailInteractions between Active-Site-Serine Beta-Lactamases and Compounds Bearing a Methoxy Side Chain on the Alpha-Face of the Beta-Lactam Ring: Kinetic and Molecular Modelling Studies
Matagne, André ULg; Lamotte-Brasseur, J.; Dive, Georges ULg et al

in Biochemical Journal (1993), 293((Pt 3)), 607-611

The interactions between three class A beta-lactamases and compounds bearing a methoxy side chain on the alpha-face of the beta-lactam ring (cefoxitin, moxalactam and temocillin) have been studied. When ... [more ▼]

The interactions between three class A beta-lactamases and compounds bearing a methoxy side chain on the alpha-face of the beta-lactam ring (cefoxitin, moxalactam and temocillin) have been studied. When compared with the situation prevailing with good substrates, both acylation and deacylation steps appeared to be severely impaired. Molecular modelling studies of the structures of the Henri-Michaelis complexes and of the acyl-enzymes indicate a major displacement of the crystallographically observed water molecule which connects the glutamate-166 and serine-70 side chains and underline the role of this water molecule in both reaction steps. [less ▲]

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See detailTreatment of TSH-secreting pituitary adenomas with octreotide : A floow-up of 52 patients
Chanson, Philippe; Weintraub, Bruce D; Harris, Alan G et al

in Annals of Internal Medicine (1993), 119(3), 236-240

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See detailMixed Phenotype Murine Leukemias
Defresne, Marie-Paule ULg; Borremans, B.; Verhofstede, C. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(8), 1253-60

Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed ... [more ▼]

Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed phenotype with myeloid cytochemical markers, pre-B surface antigens and molecular markers of pro-B lymphocytes. They represent murine models for mixed phenotype (pro-pre-B-myeloid) leukemias. [less ▲]

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See detailMembrane Translocation and Relationship with MHC Class I of a Human Thymic Neurophysin-Like Protein
Geenen, Vincent ULg; Vandersmissen, E.; Cormann-Goffin, N. et al

in Thymus (1993), 22(1), 55-66

Thymic epithelial and nurse cells (TEC/TNC) synthesize an oxytocin (OT)-like peptide in association with a neurophysin (NP)-related protein in a way similar to in the hypothalamo-neurohypophysial (NHP ... [more ▼]

Thymic epithelial and nurse cells (TEC/TNC) synthesize an oxytocin (OT)-like peptide in association with a neurophysin (NP)-related protein in a way similar to in the hypothalamo-neurohypophysial (NHP) system. The central T-cell tolerance of the NHP neuroendocrine functions have been proposed to be mediated through these thymic NHP-related peptides due to their close homology with the NHP neurohormones OT and vasopressin (VP). In order to investigate their putative presentation by proteins of the major histocompatibility complex (MHC), human thymic membranes were purified and passed through an immunoaffinity column using mAb B9.12 directed to the monomorphic determinant of human MHC class I proteins. This methodology provided the following observations: (1) a NP-like protein is translocated in human thymic membranes and is retained by B9.12 on the column; (2) the MW of this NP-like material (50-55 kD) is quite different from the MW of hypothalamic NP proteins (10 kD), and (3) this thymic NP-like protein could be identified on Western blots with mAb B9.12. The precise extent of this relationship between the thymic NP-like protein and the Ig/MHC superfamily is actually investigated through the characterization of the genetic mechanisms responsible for the thymic expression of NHP-related peptides. Given the physiological importance of OT and of its binding to NP for transport along the axonal processes of the NHP tract, we postulate that, somewhat analogously, the thymic NP-/MHC class I-related protein could be involved in the presentation of the OT-like peptide to immature T-cells. [less ▲]

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See detailHypofractionation in retinoblastoma: an increased risk of retinopathy.
Coucke, Philippe ULg; Schmid; Balmer et al

in Radiotherapy & Oncology (1993), 28(2), 157-161

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See detailNew Pyridobenzodiazepine Derivatives as Potential Antipsychotics: Synthesis and Neurochemical Study
Liégeois, Jean-François ULg; Bruhwyler, J.; Damas, Jacques ULg et al

in Journal of Medicinal Chemistry (1993), 36(15), 2107-14

The discovery of a new, safe, atypical antipsychotic remains an important challenge. To achieve this goal, a series of N-methylpiperazinopyrido[2,3-b] [1,4]- and -[1,5]- and -pyrido[4,3-b][1,4]- and -[1,5 ... [more ▼]

The discovery of a new, safe, atypical antipsychotic remains an important challenge. To achieve this goal, a series of N-methylpiperazinopyrido[2,3-b] [1,4]- and -[1,5]- and -pyrido[4,3-b][1,4]- and -[1,5]- benzodiazepines were synthesized. The dopaminergic (D1, D2), serotonergic (5-HT2), and cholinergic (M) affinities, frequently remarked in the action mechanisms of antipsychotic drugs, were determined using their respective in vitro receptor binding assays. All affinities were reduced for each compound. Optimal substituents were found to be in the 2- or 8-position for the retention of affinities, while substitution at the 5-position by acyl or alkyl groups dramatically diminished binding affinities. Pyridobenzodiazepine derivatives, such as clozapine, were found to be inactive or only weakly effective against apomorphine-mediated stereotypes in rats. In an original and complex behavioral model developed in dogs and successfully used to differentiate distinct classes of psychotropic drugs and to discriminate between typical and atypical neuroleptic drugs, 8-chloro-6-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b] [1,4]benzodiazepine (9), 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido [2,3-b][1,4]benzodiazepine (12), and 5-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b][1,5]benzodiazepine (16) showed most of the behavioral characteristics previously described for neuroleptics. Their neurochemical profiles, particularly their 5-HT2/D2 pKi ratios, were compatible with an atypical antipsychotic effect. These compounds were selected for further investigation. The proposed modulations could lead to new possibilities for the pharmacochemistry of diarylazepines. [less ▲]

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See detailThe Dual Role of Thymic Neurohypophysial-Related Self Peptides in T Cell Selection. Physiological and Pharmacological Implications
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Annals of the New York Academy of Sciences (1993), 689

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See detailCorrigenda to the 4th edition of the Bright Star Catalogue
Renson, Pierre ULg

in Bulletin d'Information du Centre de Données Stellaires (1993), 43

Not Available

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See detailVers l'interdiction d'expulsion des étrangers intégrés?, note sous Cour européenne des droits de l'homme, 26 mars 1992
Carlier, Jean-Yves ULg

in Revue Trimestrielle des Droits de l'Homme [= RTDH] (1993), 4(15), 449-466

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See detailEffect of hot N(4S) atoms on the NO solar cycle variation in the lower thermosphere
Gérard, Jean-Claude ULg; Shematovich, V. I.; Bisikalo, D. V.

in Journal of Geophysical Research (1993), 98

The variation of the nitric oxide peak density near 110 km with solar activity is calculated using a photochemical diffusive model of thermospheric odd nitrogen. This model includes the reaction of ... [more ▼]

The variation of the nitric oxide peak density near 110 km with solar activity is calculated using a photochemical diffusive model of thermospheric odd nitrogen. This model includes the reaction of translationally excited ('hot') nitrogen atoms with O2 as a source of nitric oxide, in addition to the classical photochemistry. It is confirmed that the dissociation of N2 by energetic photoelectrons due to the ionization of atmospheric constituents by solar soft X-rays is an important source of atomic nitrogen which controls the observed NO maximum near 110 km. The consideration of the hot N(4S) source increases the NO peak density by 45 to 60 percent dependent on the solar activity level considered. The calculated NO peak density increases by a factor of about 3.5 from low to high solar activity conditions, in agreement with the Solar Mesosphere Explorer satellite observations. The absolute concentrations calculated in the model with an N(2D) effective yield of 54 percent from N2 electron impact dissociation are midway between the two sets of solar cycle NO variation measurements currently available. [less ▲]

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See detailUn messager intercellulaire original, le NO (monoxyde d'azote)
Liégeois, Jean-François ULg; Damas, Jacques ULg

in Revue Médicale de Liège (1993), 48(7), 406-13

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See detailDiagnostic des infections cutanées par les herpes virus de types simplex et varicelle-zona
Nikkels, Arjen ULg; Hermanns-Lê, Trinh ULg; Tassoudji, Nazli ULg et al

in Revue Médicale de Liège (1993), 48(7), 401-405

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See detailLe clonage par transfert de noyau dans l'espèce bovine: premiers résultats
Ectors, Francis ULg; Ectors, Fabien ULg; Delval, Alain et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1993), 148

In 1987, Prather et al. have performed the first embryo cloning by nuclear transfer in the bovine species. Since, many researchers try to develop and to apply the technique. While the enucleation of the ... [more ▼]

In 1987, Prather et al. have performed the first embryo cloning by nuclear transfer in the bovine species. Since, many researchers try to develop and to apply the technique. While the enucleation of the recipient oocyte, the injection of the donor blastomere and the fusion procedure are now well controlled, on the other hand, maturation and activation as the development and freezing of the cloned embryos need tobe more investigated. The cloned embryo is more fragile. An increase in embryonic mortality is observed after transfer in a recipient cow. [less ▲]

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See detailRecent and prospective decorrelation techniques for image processing
Comes, Serge; Maes, Stéphane; Van Droogenbroeck, Marc ULg

in Annales des Télécommunications = Annals of Telecommunications (1993), 48(7-8), 390-403

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See detailThird-body irradiation as an effective palliative treatment for painful multiple bone metastases resistant to chemo- or hormonal treatment
Douglas, P; Rossier, Ph.; Mirimanoff, R-O et al

in Radiotherapy & Oncology (1993), 28(1), 76-78

Fifty-three patients had 54 third-body areas irradiated for breast and prostate bone metastases using the third-body irradiation technique during a period of 6 years. These patients were previously ... [more ▼]

Fifty-three patients had 54 third-body areas irradiated for breast and prostate bone metastases using the third-body irradiation technique during a period of 6 years. These patients were previously treated with chemotherapy, hormonal therapy and limited field irradiation. Seventy percent responded completely and 24% partially. This modality is safe and effective for pain relief. [less ▲]

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See detailPresurgical Octreotide Treatment in Acromegaly
Stevenaert, Achille ULg; Beckers, Albert ULg

in Acta Endocrinologica (1993), 129(1), 18-20

The effects of octreotide pretreatment before surgery were assessed in 48 acromegalic patients who underwent trans-sphenoidal surgery to remove pituitary adenoma, and compared with 107 patients who did ... [more ▼]

The effects of octreotide pretreatment before surgery were assessed in 48 acromegalic patients who underwent trans-sphenoidal surgery to remove pituitary adenoma, and compared with 107 patients who did not receive octreotide before surgery. Pretreated patients received octreotide 100 micrograms, thrice daily for 3 to 6 weeks (group 1), or 100 to 500 micrograms, thrice daily for 3 to 39 months (group 2). Total remission of symptoms was seen in 54%. Partial remission of symptoms occurred in 39%. Octreotide pretreatment reduced plasma GH levels by > or = 50% in all patients. GH levels were reduced to < 2 micrograms/1 in 3/14 group 1 cases and 13/34 group 2 cases. Tumour shrinkage occurred in 56.5% of patients. Marked tumour shrinkage (> 25%) occurred in more group 2 patients (10/32 vs 1/14). The tumour was soft in 39 patients, firm in 6 and hard in 3 cases. Soft consistency aided surgical removal of adenomas. Remission was greater in enclosed adenomas than in invasive tumours in both octreotide pretreated and nonpretreated acromegalics (76 vs 30%). Remission was more likely if the adenoma was less than 16 mm. Remission rate was significantly greater (p < 0.05) in all octreotide pretreated than in untreated patients for enclosed adenoma, but not for invasive adenoma. Octretide pretreatment can be recommended for three to four months prior to surgery. [less ▲]

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See detailEffect of Transdermal 17 Beta-Estradiol and Oral Conjugated Equine Estrogens on Biochemical Parameters of Bone Resorption in Natural Menopause
Reginster, Jean-Yves ULg; Christiansen, C.; Dequinze, B. et al

in Calcified Tissue International (1993), 53

OBJECTIVE: To evaluate and compare the effects or oral and transdermal estrogen replacement therapy on biochemical markers of bone resorption in early postmenopausal women. DESIGN: Controlled, randomized ... [more ▼]

OBJECTIVE: To evaluate and compare the effects or oral and transdermal estrogen replacement therapy on biochemical markers of bone resorption in early postmenopausal women. DESIGN: Controlled, randomized group comparison. SETTING: Outpatient clinic for menopausal women and research into osteoporosis. SUBJECTS: Sixty healthy women menopausal for less than 5 years and who had never received any medications interfering with bone metabolism. INTERVENTIONS: The 60 women were randomly allocated to 3 months therapy with either oral conjugated estrogens (0.625 mg/day) (n = 28) or transdermal estradiol (50 micrograms/day) (n = 32) in cyclical combination with medroxyprogesterone acetate (5 mg/day). MAIN OUTCOME MEASURES: Traditional (urinary calcium/creatinine and hydroxyproline/creatinine) and the new specific (urinary pyridinoline/creatinine and deoxypyridinoline/creatinine) markers of bone resorption were determined before and after 3 months of treatment. RESULTS: In both groups, circulating levels of estrone and estradiol were significantly (P < 0.001) increased during treatment. In women treated with oral conjugated equine estrogens, urinary calcium/creatinine and hydroxyproline/creatinine ratios were significantly (P < 0.05) reduced. Pyridinoline/creatinine ratio fell from 69.1 (4) [mean (SEM)] to 50 (4) mumol/mumol (P < 0.01) and deoxypyridinoline/creatinine ratio fell from 10.8 (1) [mean (SEM)] to 8.3 (0.8) mumol/mumol (P < 0.01). In the group treated with transdermal estradiol, urinary hydroxyproline/creatinine ratio was significantly (P < 0.05) reduced. Pyridinoline/creatinine ratio fell from 66.3 (4) [mean (SEM)] to 46.2 (3) mumol/mumol (P < 0.01) and deoxypyridinoline/creatinine ratio fell from 11.5 (1.5) [mean (SEM)] to 7.7 (0.6) mumol/mumol (P < 0.01). There were no differences between the evolution of the biochemical variables in the two groups. CONCLUSION: These results suggest that oral conjugated equine estrogens and transdermal estradiol, in the given doses, are equally effective in reducing postmenopausal bone resorption. [less ▲]

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See detailInteractions between Tumoral Mcf7 Cells and Fibroblasts on Matrigel and Purified Laminin
Noël, Agnès ULg; Nusgens, Betty ULg; Lapiere, C. H. et al

in Matrix (Stuttgart, Germany) (1993), 13(4), 267-73

A reconstituted basement membrane (matrigel) and/or fibroblasts promote the growth of human breast tumors in athymic nude mice. We have investigated in vitro the effect of matrigel or purified ... [more ▼]

A reconstituted basement membrane (matrigel) and/or fibroblasts promote the growth of human breast tumors in athymic nude mice. We have investigated in vitro the effect of matrigel or purified glycoproteins (laminin and fibronectin) on tumoral MCF7 cells-fibroblasts interactions. In coculture on matrigel, MCF7 cells organized into clusters attached on top of fibroblasts aggregates. During the process resulting in tumor cells-fibroblasts aggregation, fibroblasts actively migrated while MCF7 cells were passively transported. Using purified proteins, specific antibodies and synthetic peptides, we show that cell aggregation induced by immobilized and soluble laminin is antagonized by exogenous fibronectin or fibronectin synthesized by fibroblasts. [less ▲]

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See detailComparative evaluation of three heat and moisture exchangers during short-term postoperative mechanical ventilation
Sottiaux, Thierry; Mignolet, Ghislaine ULg; Damas, Pierre ULg et al

in CHEST (1993), 104(1), 220-224

This study compared performance of three heat and moisture exchangers (HME) during short-term postoperative mechanical ventilation. Temperature and absolute humidity (AH) were measured at various points ... [more ▼]

This study compared performance of three heat and moisture exchangers (HME) during short-term postoperative mechanical ventilation. Temperature and absolute humidity (AH) were measured at various points of the ventilatory circuit. There was no statistical difference between the groups, regarding ambient and body To, body weight, fraction of inspired oxygen, tidal volume, and respiratory rate. Only the hygroscopic HME (groups 2 and 3) provide adequate conditioning with regard to AH and To of the inspiratory gases. The performance of hydrophobic HME (group 1) was inferior and appears to be unsatisfactory. Indirect evaluation (variations of inspiratory gases and tracheal temperatures, AH of the expired gases) confirmed the superiority of the hygroscopic HME. These data suggest that humidification of inspiratory gases with a hygroscopic HME is a defensible practice during short-term postoperative mechanical ventilation. Performance of hydrophobic HME may be weak and can expose the patient to an unacceptable risk of endotracheal tube occlusion. [less ▲]

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See detailCharacterization of the regulatory functions of varicella-zoster virus open reading frame-4 gene-product
Defechereux, Patricia; Melen-Lamalle, Laurence ULg; Baudoux, Laurence et al

in Journal of Virology (1993), 67(7), 4379-4385

Varicella-zoster virus (VZV) open reading frame 4 (ORF4) encodes a protein with a predicted molecular weight of 51,540 presenting amino acid sequence homology with the immediate-early regulatory protein ... [more ▼]

Varicella-zoster virus (VZV) open reading frame 4 (ORF4) encodes a protein with a predicted molecular weight of 51,540 presenting amino acid sequence homology with the immediate-early regulatory protein ICP27 of herpes simplex virus type 1. To investigate the regulatory properties of the ORF4 gene product, we performed a series of transient expression assays in Vero cells, using a plasmid expressing ORF4 as effector and several VZV genes and heterologous genes as targets. The VZV target plasmids contained promoter/regulatory regions from genes belonging to the three putative VZV kinetic classes fused to the chloramphenicol acetyltransferase (CAT) gene. The heterologous target plasmids consisted of promoter/regulatory regions of human cytomegalovirus, Rous sarcoma virus, and human immunodeficiency virus type 1 fused to the reporter gene. These experiments demonstrated that the ORF4 gene product activated expression of ORF62 in a dose-dependent fashion but had no effect on the expression of the three other putative immediate-early genes (ORF4, ORF61, and ORF63). When various amounts of ORF4 were transfected in the presence of early gene promoters, dose-dependent transactivation was evidenced with the thymidine kinase gene (ORF36) and the major DNA-binding protein gene (ORF29) promoters; interestingly, little activity was detected with the promoter of the DNA polymerase gene (ORF28). No activation of late gene expression, represented by the glycoprotein I and glycoprotein II genes, was seen even over a wide range of concentrations of input ORF4 plasmid. Expression of pCMVCAT, pRSVCAT, and pHIVCAT was also stimulated by the ORF4 gene product. CAT mRNA analysis showed that activation of VZV target promoters occurs at the transcriptional and/or posttranscriptional level. [less ▲]

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See detailSuprasellare Raumforderung als Erstmanifestation einer Tuberkulose im Kindesalter.
Reul, J.; RAMAEKERS, Vincent ULg; Thron, A.

in Deutsche medizinische Wochenschrift (1946) (1993), 118(22), 820-4

Three days after having sustained a mild trauma to the head a seven-year-old boy developed seizure-like rotatory vertigo. Computed tomography, magnetic resonance imaging and cerebral angiography ... [more ▼]

Three days after having sustained a mild trauma to the head a seven-year-old boy developed seizure-like rotatory vertigo. Computed tomography, magnetic resonance imaging and cerebral angiography demonstrated a suprasellar space-occupying lesion. Pulmonary tuberculosis was discovered in subsequent diagnostic work-up. Cerebrospinal fluid examination was unremarkable except for immunological tests (tuberculostearic acid) which pointed to central nervous system (CNS) involvement so that a tuberculoma was suspected. The lesion decreased in size on tuberculostatic treatment (200 mg/d isoniazid, 200 mg/d rifampicin, two times 250 mg/d pyrazinamide). In the next 12 months there merely persisted a mild abnormality of the blood-brain barrier with a little contrast-medium uptake, which regressed in the following 6 months. The differential diagnosis between CNS tuberculosis and brain tumour or pyogenic abscess can be difficult in children if there are no pulmonary signs and/or the cerebrospinal fluid is normal. [less ▲]

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See detailThe Addition of Nine Residues at the C-Terminus of Human Prolactin Drastically Alters Its Biological Properties
Goffin, Vincent; Struman, Ingrid ULg; Goormaghtigh, E. et al

in European Journal of Biochemistry (1993), 214(2), 483-90

We have added nine extra residues to the C-terminal of human prolactin and analysed the effect of this mutation on the ability of the hormone to bind to its lactogenic receptor and to induce Nb2 cell ... [more ▼]

We have added nine extra residues to the C-terminal of human prolactin and analysed the effect of this mutation on the ability of the hormone to bind to its lactogenic receptor and to induce Nb2 cell division. Both properties are markedly affected when compared to the natural 23-kDa human prolactin. Since no alteration of the global protein folding was detected either by circular dichroism or by infrared spectroscopy, the decrease in biological potency can be exclusively attributed to an effect of the nine additional residues on their near environment. From infrared analysis and secondary structure prediction, the elongated tail is assumed to be involved in a beta-sheet with a few residues initially belonging to the fourth helix. Moreover, from the X-ray structures of porcine and human growth hormones, two proteins homologous to prolactins, the nine extra residues are likely to fold within a concave pocket delimited by helices 1 and 4, and the second half of the loop connecting helices 1 and 2 (loop 1). Thereby, we suggest that the additional residues prevent some residues belonging to this pocket from interacting with the lactogenic receptor. This is in perfect agreement with our earlier proposal that the binding site of prolactin to the lactogenic receptor is homologous to that of growth hormone to the somatogenic receptor, i.e. essentially composed of residues belonging to this concave pocket. [less ▲]

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See detailCoupled buoyancy and thermocapillary convection in a viscoelastic Maxwell fluid
Dauby, Pierre ULg; Parmentier, P.; Lebon, Georgy ULg et al

in Journal of Physics : Condensed Matter (1993), 5

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See detailCharacterization of the Sporulation-Related Gamma-D-Glutamyl-(L)Meso-Diaminopimelic-Acid-Hydrolysing Peptidase I of Bacillus Sphaericus NCTC 9602 as a Member of the Metallo(Zinc) Carboxypeptidase A Family. Modular Design of the Protein
Hourdou, Marie-Laure; Guinand, Micheline; Vacheron, Marie-Jeanne et al

in Biochemical Journal (1993), 292(Pt 2), 563-570

The sporulation-related gamma-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 has been analysed by proton-induced X-ray emission. It contains 1 equivalent ... [more ▼]

The sporulation-related gamma-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 has been analysed by proton-induced X-ray emission. It contains 1 equivalent Zn2+ per mol of protein. As derived from gene cloning and sequencing, the B. sphaericus Zn peptidase I is a two-module protein. A 100-amino-acid-residue N-terminal domain consisting of two tandem segments of similar sequences, is fused to a 296-amino-acid-residue C-terminal catalytic domain. The catalytic domain belongs to the Zn carboxypeptidase A family, the closest match being observed with the Streptomyces griseus carboxypeptidase [Narahashi (1990) J. Biochem. 107, 879-886] and with the family prototype, bovine carboxypeptidase A. The catalytic domain of the B. sphaericus peptidase I possesses, distributed along the amino-acid sequence, peptide segments, a triad His162-Glu165-His307 and a dyad Tyr347-Glu366 that are equivalent to secondary structures, the zinc-binding triad His69-Glu72-His196 and the catalytic dyad Tyr248-Glu270 of bovine carboxypeptidase A respectively. The N-terminal repeats of the B. sphaericus peptidase I have similarity with the C-terminal repeats of the Enterococcus hirae muramidase 2, the Streptococcus (now Enterococcus) faecalis autolysin and the Bacillus phi PZA and phi 29 lysozymes, to which a role in the recognition of a particular moiety of the bacterial cell envelope has been tentatively assigned. Detergents enhance considerably the specific activity of the B. sphaericus peptidase I. [less ▲]

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See detailClinical application of a noninvasive multi-electrode array EMG for the recording of single motor unit activity.
RAMAEKERS, Vincent ULg; Disselhorst-Klug, C.; Schneider, J. et al

in Neuropediatrics (1993), 24(3), 134-8

Using a recently developed noninvasive EMG recording technique with multi-electrode arrays we investigated the pattern and distribution of motor unit action potentials (MUAP) following maximal voluntary ... [more ▼]

Using a recently developed noninvasive EMG recording technique with multi-electrode arrays we investigated the pattern and distribution of motor unit action potentials (MUAP) following maximal voluntary contraction of the musculus abductor pollicis brevis. An additional parameter, i.e. muscular conduction velocity (CV) in single motor units, was calculated from the multi-electrode array EMG recordings. From 63 healthy children of various age the normal EMG pattern and CV were derived and compared to the EMG of diagnosed patients known to suffer from Duchenne muscular dystrophy and from spinal muscular atrophy. In normal individuals the muscular CV in neonates was lowest at 1-2 m/s and gradually reached a plateau of 2.9-4 m/s from the age of 4 years onwards. The EMG in 31 children with Duchenne muscular dystrophy showed an abnormal pattern with low amplitude action potentials. In 30 out of 31 patients a significantly lower muscular CV was found. In 10 children with spinal muscular atrophy the EMG showed action potentials of abnormally large amplitude and a reduced recruitment of firing motor units. The muscular CV remained within the normal range. Compared to classical needle EMG the application of this new noninvasive EMG technique in children is painless and offers an easy-to-handle diagnostic tool to differentiate between neuromuscular diseases of denervating or of myopathic origin. [less ▲]

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See detailLaryngeal Mask
Janssens, Marc ULg; Lamy, Maurice ULg

in Intensive Care World (1993), 10(2), 99-102

The laryngeal mask, provides a totally patent airway when positioned in the hypopharynx with remarkable patient tolerance, even at very light planes of sedation. The major advantages of the laryngeal mask ... [more ▼]

The laryngeal mask, provides a totally patent airway when positioned in the hypopharynx with remarkable patient tolerance, even at very light planes of sedation. The major advantages of the laryngeal mask are its ease of insertion, the absence of contact with the vocal cards, and the fact that it frees the hands of the anesthesiologist. Contraindications to its use result from its failure to seal the airway against regurgitation of gastric content. Laryngeal masks can be used easily instead of facial masks during anesthesia with spontaneous ventilation and, with experience, can be used for longer procedures using controlled ventilation. Suspected difficult intubation and establishment of a patent airway in emergency conditions are good indications for the use of this device. The laryngeal mask does not replace endotracheal intubation. It can, however, permit better management of the airway while waiting for personnel trained in endotracheal intubation. The nature of the pulmonary pathology seen in intensive care patients limits use of the laryngeal mask during intensive care. In the operating room few complications have been described, and postoperative discomfort is minimal. The laryngeal mask is a device positioned in the hypopharynx which allows separation of the digestive tract from the airway, without violation of either the larynx or the upper oesophageal sphincter. An endotracheal tube, because of its positioning, hinders normal glottic movement and narrows the airway.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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