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See detailMutations in type 1 procollagen that cause osteogenesis imperfecta: effects of the mutations on the assembly of collagen into fibrils, the basis of phenotypic variations, and potential antisense therapies.
Prockop, D. J.; Colige, Alain ULg; Helminen, H. et al

in Journal of Bone and Mineral Research (1993), 8 Suppl 2

Work by a large number of investigators over the last decade has established that over 90% of patients with osteogenesis imperfecta have mutations in one of the two genes for type I procollagen, that most ... [more ▼]

Work by a large number of investigators over the last decade has established that over 90% of patients with osteogenesis imperfecta have mutations in one of the two genes for type I procollagen, that most unrelated probands have different mutations in the genes, and that the mutations found in most of the serious variants of the disease cause synthesis of abnormal pro alpha chains of the protein. The results have demonstrated that synthesis of structurally abnormal but partially functional pro alpha chains can interfere with folding of the central region of the protein into a triple-helical conformation, prevent processing of the N-terminal propeptides of procollagen, or produce subtle alterations in conformation that interfere with the self-assembly of the protein into collagen fibrils. One of the unsolved mysteries about the disease is why some mutations produce severe phenotypes, whereas very similar mutations produce mild phenotypes. Recent studies in transgenic mice suggest that nongenetic factors, such as stochastic events during development, may determine the severity of the disease phenotype produced by a specific mutation. Also, recent results raised the possibility that strategies of antisense gene therapy may be effective in treating the disease some time in the future. Specific inhibition of expression of a mutated collagen gene has been obtained with antisense oligonucleotides in cell culture experiments. However, there is no means of selective delivery of antisense oligonucleotides to the appropriate tissues. [less ▲]

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See detailMeasurement of the 2s2p2(4P)3s 3P2 lifetime in N II by beam-foil-laser spectroscopy
Bastin, Thierry ULg; Baudinet-Robinet, Y.; Garnir, Henri-Pierre ULg et al

in Journal Physical II (1993), 3

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the ... [more ▼]

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the beam-foil lifetime values reported previously for the 3s' 3P term. No theoretical value for the lifetime of this term is available at the present time. [less ▲]

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See detailSolid-state nuclear magnetic resonance studies of the transformation of the zeolite Y catalyst in the course of hydrochlorination of 1-methylcyclohexene by thionyl chloride
Kolodziejski, Waclaw; Delaude, Lionel ULg; Laszlo, Pierre ULg et al

in Applied Catalysis A : General (1993), 98(1), 71-79

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated ... [more ▼]

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated framework aluminium in the parent sample coexisting with a small amount of immobile extra-framework aluminium at ca. -1 ppm is completely removed after just one reaction run and transformed into two distinct 6-coordinated species resonating at 0.2 and -3.1 ppm. The former line is assigned to Al(H2O)63+ cations, the latter is likely to come from a species with mixed solvation shells, probably Al(Cl-)(H2O)52+ and Al(OH-)(H2O)52+. Crystallinity of the catalyst is seriously affected by the reaction. The spectra confirm that before reaction the zeolite contains Si(3Si,1OH) and Si(2Si,2OH) groups. During the reaction most hydroxyl groups created by dealumination are removed, although some Si(3Si,1OH) remain. MAS NMR spectra are fully consistent with the proposed reaction mechanism. [less ▲]

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See detailHypofractionation in retinoblastoma: an increased risk of retinopathy.
Coucke, Philippe ULg; Mirimanoff, R-O; Schmid, C et al

in Radiotherapy & Oncology (1993), 28

Forty-four eyes in 38 children were treated between 1963 and 1991 by external radiotherapy for retinoblastoma. Treatment modalities varied widely during this period; in addition to radiotherapy there was ... [more ▼]

Forty-four eyes in 38 children were treated between 1963 and 1991 by external radiotherapy for retinoblastoma. Treatment modalities varied widely during this period; in addition to radiotherapy there was chemotherapy (16/44), photocoagulation (14/44), and laser therapy or cryotherapy (14/44). Treatment technique and dose fractionation also varied widely; lateral beam technique (39/44) versus anterior or anterior/lateral beam; doses per fraction ranged from 1 to 4.5 Gy, total doses from 30 to 61.5 Gy, and overall times from 22 to 49 days. Patients were followed at 3-month intervals, and actuarial survival at 10 years was 88%, with 62% local control. Ten eyes showed clinical evidence of retinopathy. A multivariate analysis of factors associated with increased risk of retinopathy was carried out using the Cox proportional hazards model and the mixture model of Farewell. The estimated latent time was 17 months (95% confidence interval, 14-20 months). The only factors found to be significantly associated with retinopathy were total dose multiplied by dose per fraction, or total dose normalized to the equivalent total dose in 2-Gy fractions as estimated from the LQ model, and these gave equivalent descriptions. There were trends (not significant) for increased risk of retinopathy when treatments included chemotherapy or photocoagulation, and for decreased risk (also not significant) when cryotherapy was used in conjunction with radiotherapy. No significance could be attached to any of the following: number of sites per eye, Reese-Ellsworth stage, and family history. We conclude that hypofractionation carries a significant risk for retinopathy in the treatment of retinoblastoma. [less ▲]

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See detailPalynological age for the lower part of the Hangenberg Shales in Sauerland, Germany
Higgs, K; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1993), 116(Z), 243-247

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See detailLa descendance de celt. *AKARNOS en wallon
Boutier, Marie-Guy ULg

in Revue de Linguistique Romane (1993)

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See detailPREFERENTIAL DEACTIVATION OF THE S(3) STATE OF THE WATER-OXIDIZING COMPLEX, FAVORED BY PLASTOQUINONE REDUCTION IN BARLEY CHLOROPLASTS
Franck, Fabrice ULg; SCHMID, G. H.

in Zeitschrift Fur Naturforschung C-A Journal Of Biosciences (1993), 48(7-8), 603-608

The flash patterns of oxygen evolution after pre-illumination by continuous light or by a flash sequence were compared in etiochloroplasts and mature chloroplasts of barley. In both types of plastids sub ... [more ▼]

The flash patterns of oxygen evolution after pre-illumination by continuous light or by a flash sequence were compared in etiochloroplasts and mature chloroplasts of barley. In both types of plastids sub-saturating continuous illumination of some seconds strongly affected the S3 but not the S2 state of the oxygen-evolving complex. This result is ascribed to efficient charge recombination of S3 with the acceptor side of photosystem II, favoured by partial reduction of the plastoquinone pool. The increase of S3 observed in the presence of dichlorophenolindophenol in etiochloroplasts confirms this interpretation. These observations strengthen the recent hypothesis of a conformational change during the transition from S2 to S3 recently proposed to interpret the different susceptibility of these two states to hydroxylamine and hydrazine (F. Frank and G. H. Schmid, Biochim. Biophys. Acta 977, 215-218 (1989); J. Messinger, U. Wacker, and G. Renger, Biochemistry 30,7852-7862 (1991)). [less ▲]

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See detailHomologous recombinant growth hormone and calcium metabolism in the tilapia oreochromis mossambicus, adapted to freshwater
Flik, G.; Atsma, W.; Fenwick, J. C. et al

in Journal of Experimental Biology (1993)

Homologous recombinant tilapia growth hormoe was tested for its effect on calcium metabolism in freshwater tilapia Oreochromis mossambicus. A comparison of the role of GH and prolactin in calcium ... [more ▼]

Homologous recombinant tilapia growth hormoe was tested for its effect on calcium metabolism in freshwater tilapia Oreochromis mossambicus. A comparison of the role of GH and prolactin in calcium regulation of the tilapia led to the conclusion that GH has specific calciopropic effects on freshwater Tilapia that differ from those of prolactin. [less ▲]

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See detailSub-mesoscale Air-sea Interactions
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Journal of Marine Systems (1993), 4(2-3),

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See detailHigh-Grade Pleomorphic T Cell Lymphoma with Restricted Involvement of Skin and Bone Marrow
Gautier, M. S.; Pierard, Gérald ULg; Andrien, Francine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1993), 186(4), 287-9

Pleomorphic T cell lymphoma of the medium to large cell type expressing CD30 antigen is a most aggressive peripheral T cell lymphoma. Currently, there is no satisfactory treatment available for this ... [more ▼]

Pleomorphic T cell lymphoma of the medium to large cell type expressing CD30 antigen is a most aggressive peripheral T cell lymphoma. Currently, there is no satisfactory treatment available for this neoplasm. We report the case of a woman with prominent skin and bone marrow involvement without detectable lymph node localization. This unusual presentation of disease responded well to polychemotherapy combined with autologous bone marrow transplantation. [less ▲]

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See detailHeightened selectivity in aromatic nitrations and chlorinations by the use of solid supports and catalysts
Delaude, Lionel ULg; Laszlo, Pierre ULg; Smith, Keith

in Accounts of Chemical Research (1993), 26(12), 607-613

The heightened selectivity in aromatic nitrations and chlorinations using solid supports and catalysts is reviewed with 67 references.

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See detailMicrosatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated QTL
Georges, Michel ULg; Lathrop, M.; Dietz, A. B. et al

in Proceedings of the National Academy of Sciences of the United States of America (1993), 90

A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from ... [more ▼]

A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from a pleiotropic effect of a single gene, or from linkage disequilibrium between the gene causing weaver disease and a quantitative trait locus (QTL) for milk production. To test these hypotheses, we performed an extensive linkage study in a bovine pedigree segregating for the weaver condition and identified a microsatellite locus (TGLA116) closely linked to the weaver gene (zmax, 8.15; theta, 0.03). TGLA116 and, by extension, the weaver locus were assigned to bovine synteny group 13. This microsatellite can be used to identify weaver carriers, to select against this genetic defect, and to study the effect of the corresponding chromosomal region on milk production in Brown Swiss and other breeds of cattle. [less ▲]

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See detailTransmission du virus BVD/MD et aspects épidémiologiques de l'infection
Boulanger, D.; Quatpers, D.; Mignon, Bernard ULg et al

in Bulletin des Groupements Techniques Vétérinaires (1993), 4

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See detailExteroceptive suppression of temporalis muscle activity: methodological and physiological aspects.
Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1993), 13(1), 3-10

In recent years studies of the suppression of EMG activity in temporalis muscle induced by stimulation in the trigeminal territory have opened new perspectives in headache research. The various methods ... [more ▼]

In recent years studies of the suppression of EMG activity in temporalis muscle induced by stimulation in the trigeminal territory have opened new perspectives in headache research. The various methods that have been used in different laboratories are reviewed and some of the physiological modulations of temporalis exteroceptive suppression are described. Among different methods of recording, averaging 10 full-wave rectified EMG responses produces results with acceptable variability and discomfort. In order to obtain maximal responses the intensity of the stimulation should reach at least 20 mA. To avoid habituation of the second temporalis exteroceptive suppression period (ES2), the stimulation frequency has to be at 0.1 Hz or below. The level of voluntary contraction is not a critical variable as long as it reaches 50% of maximum. Some physiological variations of temporalis suppression are well documented. In females, ES2 is shorter during menstruation than at mid-cycle and correlated with the estradiol/progesterone ratio in plasma. Conditioning temporalis ES2 by a preceding peripheral stimulus markedly reduces its duration, which is partly reversible by naloxone. Various pharmacological agents are able to modify temporalis ES2: its duration is increased by 5-HT1 antagonists, but decreased by 5-HT uptake blockers; contradictory results have been obtained with acetylsalicylic acid. These results suggest that inhibitory brain-stem interneurons mediating temporalis ES2 are inhibited by serotonergic afferents, probably from the raphe magnus nucleus, and that the latter receives an excitatory input from the periaqueductal gray matter and other limbic structures, in part via opioid receptors. [less ▲]

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See detailProperties and primary structure of a cold-adapted lipase from an Antarctic bacterium
Arpigny, J. L.; Feller, Georges ULg; Gerday, Charles ULg

in Archives Internationales de Physiologie et de Biochimie (1993), 101

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See detailEvolution du relief au Niger occidental : rôle de la fracturation du socle précambrien et de la formation de pseudo-karsts au sein de la lithomarge et de la couverture sédimentaire
Willems, Luc ULg; Lenoir, François; Levecq, Jean-Marie et al

in Comptes-Rendus de l'Académie des Sciences de Paris (1993), 317(Série II), 97-102

The observation of several forms in the Precambrian formations, in Tertiary and Quaternary deposits brings us to propose a model of topographic evolution mainly generated by a pseudo-karst. This latter is ... [more ▼]

The observation of several forms in the Precambrian formations, in Tertiary and Quaternary deposits brings us to propose a model of topographic evolution mainly generated by a pseudo-karst. This latter is developed in sedimentary deposits and in the lithomargin, in relation with fracturation of the basement. [less ▲]

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See detailSoluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia.
Beguin, Yves ULg; Lampertz, S.; De Groote, D. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(12), 2019-2025

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL ... [more ▼]

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL) and evaluated them in relation to clinical and biological parameters of the disease, as well as serum immunoglobulin E (IgE). Compared to 31 normal individuals, 42 CLL patients had increased levels of sCD23 (98.4 +/- 127.7 versus 0.9 +/- 0.3 U/ml, p < 0.001), sIL-2R (6080 +/- 7030 versus 1420 +/- 640 pg/ml, p < 0.001), sTfR (12,100 +/- 11,250 versus 5000 +/- 1050 ng/ml, p < 0.001), and sCD8 (510 +/- 191 versus 234 +/- 89 U/ml, p < 0.001), but normal sCD4 levels. Mean sCD23 levels remained normal in patients with non-Hodgkin's lymphoma (other than small lymphocytic), Hodgkin's disease, hairy cell leukemia, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), multiple myeloma, or solid tumors. Advancing Rai clinical stage was associated with a progressive elevation of sCD23 (p < 0.001), while sCD8 (p < 0.05), sIL-2R (p < 0.001), and sTfR (p < 0.005) were highest in stage 2 patients. Discriminant analysis confirmed the value of soluble receptor determinations in the clinical evaluation of CLL patients. sCD23 correlated with sIL-2R (p < 0.001) and sTfR (p < 0.05) but not with sCD4 or sCD8, and displayed an inverse relationship with serum IgE (NS) and total gamma-globulin (p < 0.05). sIL-2R correlated with sCD23 (p < 0.001), sTfR (p < 0.001), sCD4 (p < 0.01), and sCD8 (p < 0.01). The lymphocyte count correlated with serum lactate dehydrogenase (LDH) (p < 0.05), sCD23 (p < 0.001) and sIL-2R (p < 0.01) but not sTfR, sCD8, or sCD4. Chemotherapy produced consistent reductions of sCD23 levels in two responding patients. We conclude that: (i) sCD23 is considerably elevated in CLL, correlates with the tumor mass and clinical stage, and could be helpful in monitoring these patients; and (ii) sIL-2R, sCD8, and sTfR levels are less specifically increased and could be influenced by other factors such as immune activation and erythropoiesis. [less ▲]

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See detailA sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties
Masereel, B.; Schynts, M.; Krzesinski, Jean-Marie ULg et al

in Journal of Pharmacy & Pharmacology (1993), 45

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé ... [more ▼]

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé. Their diuretic properties were studied (30 mg kg-1) after oral administration to rats. Lipophilic derivatives very active in-vitro, were found inactive orally and intraperitoneally in rats. The four most active compounds were examined for their dose-dependent diuresis. Three of them showed a potency, water and electrolyte excretion similar to torasemide. The fourth molecule, a sulphonylthiourea (BM 20), exhibited relative potassium-sparing properties and a minimal diuretic dose of 0.001 mg kg-1, 200 times lower than torasemide. [less ▲]

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See detailLe pilotage de l'enseignement des sciences : un essai de synthèse...
Rousselet, S.; Monseur, Christian ULg

in Informations pédagogiques (1993), 9

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See detailFurther studies on the genetic diversity of lima beans (Phaseolus lunatus L.) using allozymes
Maquet, Alain; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Annual Report of the Bean Improvment Cooperative (1993), 36

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See detailEnzymatic hydrolysis of reconstituted dimyristoylphosphatidylcholine-apo A-I complexes.
Lins, Laurence ULg; Piron, S.; Conrath, K. et al

in Biochimica et Biophysica Acta (1993), 1151(2), 137-42

Apolipoproteins share a common structural feature, their interaction with phospholipids. It is believed that amphipathic helical sequences enable apolipoproteins to bind to lipid bilayer and to form ... [more ▼]

Apolipoproteins share a common structural feature, their interaction with phospholipids. It is believed that amphipathic helical sequences enable apolipoproteins to bind to lipid bilayer and to form discoidal particles of defined dimensions. While the knowledge of the apo A-I sequence and secondary structure has been used to make predictions about its mode of association with lipids, the available experimental data necessary to propose a precise model of these discoidal structures are still limited. An important step in our understanding of these structures would be to identify the apolipoprotein lipid-associated domains. Proteolysis of apo A-I-DMPC reconstituted HDL (rHDL) and free apo A-I is used here to identify lipid-protected domains of apo A-I. Free cleaved peptides were separated from rHDL associated peptides by density gradient centrifugation. The lipid-associated peptides were further analyzed by SDS-PAGE and transferred by Western blot to a ProBlott membrane for sequencing. Cleavage occurred at residue 43 with proteinase K, 46 with trypsin and residue 47 or 48 with pronase. A large domain from about residue 45 to the C-terminal remains highly protected against hydrolysis eventhough it contains several bonds susceptible to proteolytic cleavage. No protected fragments were detected by SDS-PAGE after enzymatic cleavage of free apo A-I in identical experimental conditions. [less ▲]

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See detailDifferent Mechanisms of Extracellular Matrix Remodeling by Fibroblasts in Response to Human Mammary Neoplastic Cells
Noël, Agnès ULg; Munaut, Carine ULg; Nusgens, Betty ULg et al

in Invasion & Metastasis (1993), 13(2), 72-81

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties ... [more ▼]

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties. They may also directly interact with collagen fibrils leading to retraction of the matrix. We have studied in vitro the influence of various human mammary tumor cells on the proliferation rate of normal human fibroblasts and on their level of collagen synthesis, as well as their release of collagenase activity. Interactions between neoplastic cells and collagen matrix were investigated by incorporation of tumor cells in collagen gels (lattices) and measurement of their retraction. All cells tested (HBL100, SW613, SA52, MDA-MB-231, MCF7, MCF7/6, MCF7 ras, BT20 and T47D) were able to modulate the composition of the extracellular matrix by one or several of the mechanisms investigated. Our results also demonstrate an opposite regulation of collagen and collagenase production. The effects on the collagen metabolism and on fibroblast proliferation are probably mediated by soluble cytokines since they are reproduced by incubating the fibroblasts in the presence of medium conditioned by tumor cells. The desmoplastic reaction may thus result from different mechanisms dependent upon tumor cell types. [less ▲]

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See detailLaparoscopic supracervical (subtotal) hysterectomy (LASH).
Donnez, Jacques; NISOLLE, Michelle ULg

in Journal of Gynecologic Surgery (1993), 9(2), 91-4

The use of laparoscopically assisted vaginal hysterectomy with or without annexectomy has been widely discussed. We report the technique of laparoscopic supracervical (subtotal) hysterectomy (LASH), which ... [more ▼]

The use of laparoscopically assisted vaginal hysterectomy with or without annexectomy has been widely discussed. We report the technique of laparoscopic supracervical (subtotal) hysterectomy (LASH), which was first performed in 1990. Laparoscopic supracervical hysterectomy was carried out in a series of 36 women. The duration time was 60 min in experienced hands. There were no major complications. The feasibility and low morbidity rate of this laparoscopic approach led us to propose LASH in certain indications, particularly in cases of a uterus with multiple submucosal myomas where hysteroscopic therapy is less successful. [less ▲]

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See detailSurgical Technique for Cardiomyoplasty and Iterative Transthoracic Biopsies in an Experimental Goat Model
Radermecker, M. A.; Fourny, J.; Bonnet, Pierre ULg et al

in European Surgical Research = Europäische Chirurgische Forschung = Recherches Chirurgicales Européennes (1993), 25(2, Mar-Apr), 110-22

Cardiomyoplasty is a new surgical procedure using transformed skeletal muscle to reinforce or substitute for the myocardium. For the purpose of studying surgical technique and investigating basic ... [more ▼]

Cardiomyoplasty is a new surgical procedure using transformed skeletal muscle to reinforce or substitute for the myocardium. For the purpose of studying surgical technique and investigating basic questions, we have developed a model of reinforcement cardiomyoplasty. Herein, we describe anesthetic management, surgical technique, and the technique for iterative transthoracic biopsies. This model has proven to be valuable in several long-term studies involving more than 30 goats. Preliminary data to ascertain the efficacy of the proposed technique are provided. [less ▲]

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See detailPotato chloroplasts express an intron-encoded maturase-like polypeptide
du Jardin, Patrick ULg; Portetelle, Daniel ULg; Harvengt, L. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1993), 101

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See detailOstéoporose postménopausique: le point sur la thérapeutique
Reginster, Jean-Yves ULg

in Medisearch (1993), 73

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See detailApports récents de la génétique dans les maladies inflammatoires intestinales
Louis, Edouard ULg; Belaiche, Jacques ULg; Franchimont, D. et al

in Acta Clinica Belgica (1993), 48(6), 383-91

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the ... [more ▼]

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the concept of genetic heterogeneity. This new concept leads us to try to classify different forms of inflammatory bowel disease and could have in the future an impact on the prevention, the follow up and the treatment of these diseases. [less ▲]

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See detailMallarmé, “termite silencieux”. L’auto-liquidation de la poésie
Durand, Pascal ULg

in Romantisme (1993), 81

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See detailApplying the Lagamine model to compute land subsidence in Shanghai
Dassargues, Alain ULg; Schroeder, Christian ULg; Li, Xiang Lin

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailNew gamma-lactam homologs of penems
Marchand-Brynaert, Jacqueline; Couplet, Blandine; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry Letters (1993), 3(11), 2303-2308

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See detailL'agriculteur et les aides directes aux revenus
Lebailly, Philippe ULg

in Nouvelles des Sciences et des Technologies (1993), 11(2), 171-176

Le but de cet article est de présenter les différents volets de la politique agricole qui permettent un soutien aux agriculteurs par le biais d'aides directes aux revenus. Après avoir présenté le ... [more ▼]

Le but de cet article est de présenter les différents volets de la politique agricole qui permettent un soutien aux agriculteurs par le biais d'aides directes aux revenus. Après avoir présenté le dispositif mis en place en Belgique pour les régions agricoles défavorisées, l'auteur s'attarde sur les aspects de la réforme de la PAC qui introduisent les paiements directs. Les changements les plus importants concernant les cultures arables et le fonctionnement du système sont présentés de manière détaillée. Enfin, l'auteur présente les mesures d'accompagnement de la réforme de la politique des marchés et des prix. [less ▲]

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See detailPurification and Biochemical Characterization of Recombinant Human Placental Growth Hormone Produced in Escherichia Coli
Igout, Ahmed ULg; Van Beeumen, Jozef; Frankenne, Francis ULg et al

in Biochemical Journal (1993), 295(3), 719-724

The hGH-V (or hGH-2) gene codes for human placental growth hormone (hPGH). Secretion of hPGH is continuous, in contrast with the pulsed secretion of pituitary growth hormone (hGH) which it progressively ... [more ▼]

The hGH-V (or hGH-2) gene codes for human placental growth hormone (hPGH). Secretion of hPGH is continuous, in contrast with the pulsed secretion of pituitary growth hormone (hGH) which it progressively replaces in the maternal bloodstream. hGH- V cDNA has previously been cloned and isolated. Analysis of its nucleotide sequence has revealed a 191-residue protein, hPGH, differing from hGH at 13 positions. The calculated pI is more basic than that of the pituitary hormone. Here we have inserted hGH- VcDNA into the pIN-III-ompA3 plasmid in order to produce hPGH in its native form in Escherichia coli D1210. Expression of hGH- V cDNA in E. coli is significantly lower than that of hGH cDNA with the same expression system. The hPGH produced in E. coli was purified in quantities sufficient to allow its biochemical and immunochemical characterization. The molecular mass of the protein was determined by electrospray m.s. The determined mass, 22320 Da, agrees well with the molecular mass calculated from the translated cDNA sequence, assuming the presence of two disulphide bridges. Having established the technique for producing hPGH with a primary structure identical to the natural, non-glycosylated, 22 kDa isoform, we can now plan the full physicochemical and pharmaceutical characterization of this new hormonal entity. [less ▲]

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See detailAssociation of Aortic Stenosis and Gastrointestinal Bleeding (Heyde's Syndrome). Report of Two Cases
Natowitz, L.; DEFRAIGNE, Jean ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1993), 93(1), 31-3

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent ... [more ▼]

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent small intestinal bleeding originating from angiodysplasia stopped after aortic valve replacement. We report two cases of patients presenting with a recurrent small intestinal bleeding originating from digestive angiodysplasia and suffering from aortic stenosis. Diagnosis of both pathologies is well documented in both cases. The replacement of the aortic valve by a biologic prosthesis stopped the bleeding. Prior to aortic valve replacement, the two patients suffered severe recurrent blood loss from intestinal angiodysplasia. The treatment of aortic stenosis greatly favored both cardiac and general status. We recommend aortic valve replacement with a biologic prosthesis prior to intestinal resection in patients presenting with Heyde's syndrome. We stress on the fact that anticoagulants must be stopped in order to minimize the risk of further bleeding. [less ▲]

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See detailSub-mesoscale Air-sea Interactions
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Journal of Marine Systems (1993), 4(2-3),

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See detailLa compétence du juge des référés en cas de procédure d'extradition
Kefer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1993)

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See detailThe use of the soil map of Belgium in the assessment of landslide risk
Closson, Damien; Engels, Patrick ULg; Demaret, Xavier

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(3), 165172

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See detailLe nom du bison en grec et en latin
Purnelle, Gérald ULg

in Latomus : Revue d'Etudes Latines (1993), 52(3), 567-580

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See detailConditional heteroscedasticity in pacific-basin stock market returns
Corhay, Albert ULg; Tourani-Rad, Alireza

in Research in International Business and Finance (1993), 10

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return ... [more ▼]

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return-generating models which empirically fit the data are processes with conditional heteroscedastic innovations. Particularly, the generalized autoregressive conditional heteroscedastic GARCH(1,1) process turns out to be the best in most cases. [less ▲]

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See detailP. Colon. Inv. 4781 verso: vente d'une esclave
Straus, Jean ULg

in Zeitschrift für Papyrologie und Epigraphik (1993), 98

Edition du contrat de vente d'une esclave. Papyrus grec d'Egypte. Ptolémaïs Euergétis, 3 décmebre 65

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See detailHigh Resolution Frequency Analysis as applied to the singing voice
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Folia Phoniatrica (1993), 45

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the ... [more ▼]

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the resonators. This is observed especially on a low fundamental, and it is acquired through technical skill and experience (2)Observation of the vibrato, which, isolated from the clinical study, regarding only its graphic presentation, could habe been interpreted as "abnormal". [less ▲]

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See detailThe Appearance of C2H3+ Ions from C2H3F by non-resonant Photoionization. A Translational Energy Surprisal Analysis.
Momigny, J.; Locht, Robert ULg

in Chemical Physics Letters (1993), 211(2,3), 161-165

It is shown that for a photon energy of 16.85 eV the translational energy surprisal of the C2H3++F dissociation products from C2H3F+ has a bimodal behaviour. The possibility of considering the bimodal ... [more ▼]

It is shown that for a photon energy of 16.85 eV the translational energy surprisal of the C2H3++F dissociation products from C2H3F+ has a bimodal behaviour. The possibility of considering the bimodal surprisal as due to the superposition of two translational energy distributions is consistent with the theoretical assumption of the concurrence of two channels in this dissociation process. The characteristics of these distributions, i.e. the energy width and the relative abundance, are in agreement with the results of an ab initio quantum-mechanical calculation of the dynamics of this dissociation. They are consistent with the simultaneous occurrence of a statistical dissociation of C2H3F+(X2A') into C2H3+(X1A') and an isolated state dissociation of C2H3F+(C2A") into C2H3+(a3A"). Negative lambda values obtained for the surprisal of both these distributions indicate an inversion of the translational level population of the dissociation products. [less ▲]

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See detailApplication de l'analyse fréquentielle à haute résolution
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Bulletin d'Audiophonologie (1993), IX(5), 490-497

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur ... [more ▼]

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur dans le placement de la voix dans les résonateurs. Il s'observe plus particulièrement sur un fondamental grave et s'acquiert par technique et expérience. 2. L'observation du vibrato, qu'il convient d'avoir vu avant, son observation graphique pourrait être considérée comme pathologique. [less ▲]

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See detailCombination of oral antidiabetic drugs and insulin in the treatment of non-insulin-dependent diabetes.
Scheen, André ULg; Castillo, M. J.; Lefebvre, Pierre ULg

in Acta Clinica Belgica (1993), 48(4), 259-68

Non-insulin-dependent diabetes mellitus (NIDDM) appears to be an heterogeneous disorder characterized by both relative insulin deficiency and impaired insulin action. The initial management of NIDDM ... [more ▼]

Non-insulin-dependent diabetes mellitus (NIDDM) appears to be an heterogeneous disorder characterized by both relative insulin deficiency and impaired insulin action. The initial management of NIDDM should include patient education, dietary counselling and individualized programs of physical activity. It is only when such measures fail that drug therapy should be considered. Oral drug therapies include sulphonylurea derivatives, biguanides, among which metformin remains the only one commercialized in our country, and alpha-glucosidase inhibitors such as acarbose. However, insulin therapy may be required to achieve adequate glycaemic control in some patients, the so-called secondary failures to oral treatment. The rationale for combining insulin and oral drug therapy derives from a better understanding of the pathophysiology of NIDDM and of the mechanisms of action of the oral drugs available: 1) type 2 diabetic patients are both insulin-deficient and insulin-resistant, thus requiring quite high doses of exogenous insulin; 2) peripheral insulin delivery leads to hyperinsulinaemia which could play a role in the pathogenesis of late diabetic complications; 3) sulphonylureas stimulate insulin release directly into the portal vein and could also potentiate peripheral insulin action; and 4) metformin (by improving glucose metabolism and insulin sensitivity) and alpha-glucosidase inhibitors (by slowing down the digestion of complex carbohydrates and sucrose) are able to reduce the amounts of insulin needed to control postprandial hyperglycaemia. Numerous studies have shown that a combination of insulin and sulphonylurea is more effective than insulin alone in the treatment of patients with NIDDM after secondary failure to oral drugs, leading to better glucose profiles and/or decreased insulin needs. The available data suggest that combination therapy is most beneficial in the diabetic patient who still has residual insulin secretory capacity and that the best scheme comprises an evening injection of lente insulin and the administration of sulphonylureas before meals. Preliminary results suggested that insulin-metformin (when obesity is present) or insulin-acarbose (when post-prandial hyperglycaemia occurs) combinations might offer some favourable features for the treatment of NIDDM patients although these therapeutical approaches still require adequate evaluation in further controlled studies. The additional cost of such combined therapy should be weighed against the potential advantages of better metabolic control. [less ▲]

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See detailEtude de l'effet de 2 additifs à base d'extrait de Yucca sur la réduction des émissions d'azote ammoniacal par des lisiers de porcs
Marlier, Didier ULg; Nicks, Baudouin ULg; Canart, Bernard

in Annales de Médecine Vétérinaire (1993), 137(7), 485-493

The effects of two commercial yucca extracts on the ammonia release from pig slurry have been tested in laboratory and in one fattening house. In laboratory, tests were carried on with 4 litre samples ... [more ▼]

The effects of two commercial yucca extracts on the ammonia release from pig slurry have been tested in laboratory and in one fattening house. In laboratory, tests were carried on with 4 litre samples whose ammonia production was recorded during 35 days. One of the two products, at the factory recommanded dose of 5 g/l, has successfully lowered the ammonia emission rate of the slurry. In the pig house, the two same products were given in the pigs' diet at the dose of 160 and 200 g/ton of feed. Inside a same building, pigs of one room received feed plus yucca extracts and those of the second room feed alone; none of the 2 products has significantly reduced the ammonia concentrations recorded on a three month period. One can expect improvements of the yucca extracts but up to now no guaranty can be given of their efficiency. [less ▲]

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See detailMicrosatellite mapping of a gene affecting horn development in Bos taurus
Georges, Michel ULg; Drinkwater, R.; Lefort, A. et al

in Nature Genetics (1993), 4(2), 206-210

The presence or absence of horns in Bos taurus is thought to be under the genetic control of the autosomal polled locus, characterized by two alleles: P dominant over p, and causing the polled or hornless ... [more ▼]

The presence or absence of horns in Bos taurus is thought to be under the genetic control of the autosomal polled locus, characterized by two alleles: P dominant over p, and causing the polled or hornless phenotype. We have demonstrated genetic linkage between the polled locus and two microsatellite markers, GMPOLL-1 and GMPOLL-2, and have assigned the corresponding linkage group to bovine chromosome 1. This confirms the existence of the postulated polled locus and the hypothesized inheritance pattern. It will allow marker assisted selection for the polledness trait in breeding programs and is a first step towards positional cloning and molecular study of a gene that has been subjected to both natural and artificial selection. [less ▲]

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See detailMorphometric study of the stromal vascularization in peritoneal endometriosis.
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Anaf, Vincent et al

in Fertility and Sterility (1993), 59(3), 681-4

To evaluate the stromal vascularization of different appearances of peritoneal endometriosis, biopsies were taken from peritoneal areas with endometriosis in a series of 135 infertile women and classified ... [more ▼]

To evaluate the stromal vascularization of different appearances of peritoneal endometriosis, biopsies were taken from peritoneal areas with endometriosis in a series of 135 infertile women and classified as typical (black), red, or white lesions. The number of capillaries per mm2 of stroma, their mean surface area, and the ratio of capillaries/stroma surface area, and the mitotic activity were analyzed in typical, red, and white lesions. Significant differences were found between the different subgroups. The higher vascularization and mitotic activity observed in red lesions suggested the hypothesis that such lesions are very active and probably the first stage of early implantation of endometrial glands and stroma. The poor vascularization and the absence of mitosis observed in white lesions suggested that these lesions are much less active than red lesions and are a quiescent stage of the disease. Our study proves that the "activity" of peritoneal endometriosis is related to the vascularity. This concept must be considered in the further discussion of American Fertility Society Endometriosis Classification. Typical, red and white lesions are three different stages of the peritoneal disease and their relative relation to infertility is also probably different. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1993), n°1

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See detailinfections par streptocoque B en période néonatale
Battisti, Oreste ULg; Vanclaire, J.; François, A. et al

in Archives Françaises de Pédiatrie (1993), 50

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See detailPurification Of Antifungal Lipopeptides By Reversed-Phase High-Performance Liquid-Chromatography
Razafindralambo, Hary ULg; Paquot, Michel ULg; Hbid, Choukri et al

in Journal of Chromatography. A (1993), 639(1), 81-85

A rapid procedure for the purification of antifungal lipopeptides from Bacillus subtilis, a potential agent for biocontrol of plant diseases, was tested. It consists of a solid-phase extraction on C18 gel ... [more ▼]

A rapid procedure for the purification of antifungal lipopeptides from Bacillus subtilis, a potential agent for biocontrol of plant diseases, was tested. It consists of a solid-phase extraction on C18 gel followed by reversed-phase chromatography using a biocompatible PepRPC HR 515 column with a pharmacia fast protein liquid chromatographic system. This is a very effective method for isolating and fractionating iturin A and surfactin, two lipopeptides of different nature, co-produced by Bacillus subtilis strain S499. The presence of homologous lipopeptides was easily detected. [less ▲]

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See detailEscherichia coli producing CNF1 and CNF2 cytotoxins in animals with different disorders
Pohl, P.; Oswald, E.; Van Muylem, K. et al

in Veterinary Research (1993), 24

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See detailThe distensibility of the central bronchial system in calves measured by means of the monofrequency oscillation technique
Reinhold, P.; Barnikol, W. K. R.; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40

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See detailUltrastructural distribution of DNA within the ring-shaped nucleolus of human resting T lymphocytes.
Vandelaer, M.; Thiry, Marc ULg; Goessens, Guy ULg

in Experimental Cell Research (1993), 205(2), 430-2

The precise distribution of DNA within the resting human T lymphocyte nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. The ... [more ▼]

The precise distribution of DNA within the resting human T lymphocyte nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. The nucleolus is partially enveloped by a layer of condensed chromatin which, at several places, penetrates into the nucleolar body until in close contact with the fibrillar centers. Morphometric analysis reveals that 32% of the fibrillar center surface is essentially occupied by condensed chromatin. Using the in situ terminal deoxynucleotidyl transferase-immunogold procedure for detecting DNA, we further show that evident label is exclusively found over the condensed chromatin and over the fibrillar centers, whereas no significant label is detected over the dense fibrillar component of the nucleolus. [less ▲]

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See detailThe fractal nature of the power spectrum as an indicator of chaos in the Bianchi-IX cosmological model
Demaret, Jacques; De Rop, Yves ULg

in Physics Letters B (1993), 299(3-4), 223-228

Using two different methods, we compute the fractal dimension of the power spectrum associated with numerical solutions of the spatially homogeneous Bianchi IX cosmological model in Misner-Chitre ... [more ▼]

Using two different methods, we compute the fractal dimension of the power spectrum associated with numerical solutions of the spatially homogeneous Bianchi IX cosmological model in Misner-Chitre coordinates. According to Perdang's criterion, the noninteger character of this dimension is reflection of chaos and can be used to measure it, in the same spirit as the Lyapunov exponent of the Kolmogorov entropy. The results obtained indicate the chaotic nature of the behaviour of the Bianchi IX model near the cosmological singularity. [less ▲]

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See detailTHERMAL-CONDUCTIVITY OF TWINNED YBA2CU3O7-X AND TWEEDED YBA2(CU0.95FE0.05)3O7-X IN A MAGNETIC-FIELD - EVIDENCE FOR INTRINSIC PROXIMITY EFFECT
Bougrine, Hassan ULg; SERGEENKOV, S.; Ausloos, Marcel ULg et al

in Solid State Communications (1993), 86(8), 513-516

The behavior of the thermal conductivity kappa of twinned YBa2Cu3O7-x and tweeded YBa2(Cu0.95Fe0.05)3O7-x polycrystals in a magnetic field up to 5 T is presented. Data as a function of field are shown to ... [more ▼]

The behavior of the thermal conductivity kappa of twinned YBa2Cu3O7-x and tweeded YBa2(Cu0.95Fe0.05)3O7-x polycrystals in a magnetic field up to 5 T is presented. Data as a function of field are shown to depart from the usual linear behavior of thermal magnetoresistivity (TMR) kappa-1 (B) for conventional superconductors. A set of stretched exponential laws, of the form kappa-1 (B) - kappa-1 (0) = CB exp(-pB(q)) has been found to describe our data with q decreasing with temperature from 1 to 1/2 and from 1/2 to 1/4 for pure and iron-doped samples, respectively, in contrast to the unique interpolation formula (q = 1/4) for TMR proposed recently by Richardson et al. [1] to fit their data on twinned and untwinned single crystals. Such a complex behavior of TMR in the high field region is supposed to originate from extended defect mediated intrinsic proximity effect in both samples. The proposed interpretation is based on incorporating two types of phonon scatterers, free (unpinned) and pinned (by the defect cores) vortices, into a conventional picture of phonon-vortex scattering mechanism. [less ▲]

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See detailReevaluation by Image Analysis of the Effects of Fibroblasts, Fibronectin or Laminin Upon Colony Formation in Mouse Lungs by B16 Melanoma Cells
Coucke, P. H.; Lambertz, M.; Baramova, E. N. et al

in Invasion & Metastasis (1993), 13(4), 201-11

A recently described personal method based on image analysis of histological sections was used in order to quantify lung colony formation by B16 melanoma cells injected intravenously into the mouse. These ... [more ▼]

A recently described personal method based on image analysis of histological sections was used in order to quantify lung colony formation by B16 melanoma cells injected intravenously into the mouse. These tumor cells were preincubated in vitro either with fibronectin (FN), laminin (LN) or fibroblasts (FB), which are implicated in the process of invasion and metastasis. Thanks to this method, a more accurate analysis of lung colonies (section area and number) formed by tumor cells was realized. By image analysis, we show that when FB were mixed with B16 cells, a drastic increase of tumor sections number and area was induced. LN increased the tumor sections area, but not their number. No effect of FN on B16 cells was observed. LN and FN promoted tumor anchorage in the depth of the lungs while FB reduced the latter. These facts could explain the contradictory results obtained by simply counting macroscopically superficial lung colonies. When cultured in vitro, these B16 melanoma cells did not produce any type of IV collagenase, either alone or in the presence of LN or FN, but in cocultures (B16 with 3T3) and in fibroblasts cultures, this enzyme was present. This could explain, among other factors, why the rate of invasiveness exerted by B16 cells is higher when the latter are coinjected with FB. [less ▲]

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See detailAmineptine and response timing in the rat
Lejeune, Helga ULg; Hermans, Isabelle ULg; Mocaer, E. et al

in Behavioural Processes (1993), 29

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See detailonce a day administration of amikacine in neonates: assessment of nephrotoxicity and ototoxicity
Battisti, Oreste ULg; Langhendries, J. P.; Bertrand, J. M. et al

in Developmental Pharmacology and Therapeutics (1993), 20

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See detailThe Transcriptional Regulation of the Growth Hormone Gene Is Conserved in Vertebrate Evolution
Argenton, F.; Vianello, S.; Bernardini, S. et al

in Biochemical and Biophysical Research Communications (1993), 192(3), 1360-1366

Growth hormone (GH) gene expression in mammals is regulated by the interaction of the transcription factor Pit-1 with two binding sites within the proximal promoter. Four sequences, homologous to the ... [more ▼]

Growth hormone (GH) gene expression in mammals is regulated by the interaction of the transcription factor Pit-1 with two binding sites within the proximal promoter. Four sequences, homologous to the mammalian Pit-1 motif occur in the rainbow trout (Oncorhynchus mykiss) GHII (rtGH) gene promoter, two of which partly overlap. The three regions containing these putative Pit-1 binding sequences were protected from deoxyribonuclease I digestion by nuclear extracts of GC cells, a rat pituitary tumor cell line producing Pit-1. In gel shift assays, nuclear proteins from GC cells and from trout pituitaries were found to interact specifically with one of these protected sites. Transfection experiments showed that the rtGH promoter is transcnptionally active in GC cells, the response being strongly enhanced in the presence of a cAMP analogue. The results demonstrate that rat Pit-1 binds to and activates the rtGH promoter, indicating that the basic mechanisms regulating GH gene transcription have been conserved between fish and mammals. [less ▲]

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See detailEffect of prolactin on alpha and beta chloride cells in the gill epithelium of the saltwater adapted tilapia " Oreochromis niloticus"
Pisam, B.; Auperin, B.; Prunet, P. et al

in Anatomical Record (1993), 235

Tilapia (Oreochromis niloticus), 21 g average body weight, were divided into two groups. A group was maintained in fresh water, whereas another group was adapted for 2 weeks to 20% salt water. Among the ... [more ▼]

Tilapia (Oreochromis niloticus), 21 g average body weight, were divided into two groups. A group was maintained in fresh water, whereas another group was adapted for 2 weeks to 20% salt water. Among the latter, fishes were injected every 2 days for a week with tilapia prolactin (ti-PRL I). Gills were prepared for electron microscopy in order to determine the types and surface areas of chloride cells in each experimental condition. Two types of chloride cells, the alpha and beta cells were easily distinguished on the basis of their location and ultrastructural features in the gills of freshwater fishes, while only one type of cell, the saltwater alpha cells presumably derived from the transformation of the freshwater alpha cells, were encountered in saltwater adapted animals. After PRL injection of saltwater adapted fishes, small chloride cells, which displayed ultrastructural features similar to those of beta cells in freshwater tilapia, reappeared in interlamellar regions of the gills. In the same experimental conditions, the voluminous saltwater alpha cells showed a tendency to resume ultrastructural features more characteristic of the freshwater alpha cells from which they were derived. These observations tend to indicate that prolactin behaves as a "freshwater adapting hormone" and that beta cells are specifically involved in fish adaptation to freshwater living conditions. [less ▲]

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See detailThe Implications of European Union for the Performance of Public Enterprises
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in Administration : Journal of the Institute of Public Administration of Ireland (1993), 41(Summer), 149-165

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See detailElimination des métaux lourds par précipitation biologique
Toye, Dominique ULg; Schlitz, Marc; Crine, Michel ULg

in Tribune de l'Eau (La) (1993), 565

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See detailClustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells
Bellefroid, Eric J.; Marine, Jean-Christophe; Ried, Thomas et al

in EMBO Journal (1993), 12(4), 1363-1374

KRAB zinc-finger proteins (KRAB-ZFPs) constitute a large subfamily of ZFPs of the Krüppel C2H2 type. KRAB (Krüppel-associated box) is an evolutionarily conserved protein domain found N-terminally with ... [more ▼]

KRAB zinc-finger proteins (KRAB-ZFPs) constitute a large subfamily of ZFPs of the Krüppel C2H2 type. KRAB (Krüppel-associated box) is an evolutionarily conserved protein domain found N-terminally with respect to the finger repeats. We report here the characterization of a particular subgroup of highly related human KRAB-ZFPs. ZNF91 is one representative of this subgroup and contains 35 contiguous finger repeats at its C-terminus. Three mRNA isoforms with sequence identity to ZNF91 were isolated by the polymerase chain reaction. These encode proteins with a KRAB domain present, partially deleted or absent. Five genomic fragments were characterized, each encoding part of a gene: the ZNF91 gene or one of four distinct, related KRAB-ZFP genes. All exhibit a common exon/intron organization with the variant zinc finger repeats organized in a single exon and the KRAB domain encoded by two separate exons. This positioning of introns supports the hypothesis that the mRNA isoforms encoding polypeptides with variability in the KRAB domain could arise by alternative splicing. By in situ chromosomal mapping studies and by analysis of fragments from a human genomic yeast artificial chromosome library containing KRAB-ZFP genes, we show that these genes occur in clusters; in particular, a gene complex containing over 40 genes has been identified in chromosomal region 19p12-p13.1. These ZNF91-related genes probably arose late during evolution since no homologous genes are detected in the mouse and rat genomes. Although the transcription of members of this KRAB-ZFP gene subgroup is detectable in all human tissues, their expression is significantly higher in human T lymphoid cells. [less ▲]

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See detailIn vivo infection of sheep by bovine leukemia virus mutants.
Willems, Luc ULg; Kettmann, Richard ULg; Dequiedt, Franck ULg et al

in Journal of virology (1993), 67(7),

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See detailComputed subsidence of the central area of Shanghai
Dassargues, Alain ULg; Radu, Jean-Pol ULg; Charlier, Robert ULg et al

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailMathematical Programming Methods for Constrained Optimization: Dual Methods
Fleury, Claude ULg

in Progress in Astronautics and Aeronautics (1993), 150

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See detailNew f values in C I and the CNO Abundances in the Sun
Biémont, Emile ULg; Hibbert, A.; Godefroid, M. et al

in Astrophysical Journal (1993), 412

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See detailEffects of Capsaicin on the Endothelial Permeability in Isolated and Perfused Rabbit Lungs
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Fundamental & Clinical Pharmacology (1993), 7(2), 81-91

Changes in pulmonary endothelial permeability and in microvascular hemodynamics in response to capsaicin (10(-4) M) were investigated in isolated, perfused rabbit lungs. Blood-free perfusate was ... [more ▼]

Changes in pulmonary endothelial permeability and in microvascular hemodynamics in response to capsaicin (10(-4) M) were investigated in isolated, perfused rabbit lungs. Blood-free perfusate was recirculated through ventilated lungs in an isogravimetric state, under zone III conditions with a constant flow. Using the occlusions method, the total pressure gradient between the arterial and the venous levels (delta Pt) was partitioned into four components: arterial (delta Pa), pre-(delta Pa') and post-(delta Pv') capillary, and venous (delta Pv). The capillary filtration coefficient (Kf,c) was evaluated by measuring the amount of fluid filtering through the endothelium when arterial and venous pressures were suddenly increased. Capsaicin caused no changes in the vascular pressures at any level of the pulmonary circulation but induced a significant 3-fold increase in the Kf,c (P < 0.05). This reaction was accompanied by pulmonary oedema. The mechanisms involved in the permeability changes were investigated by testing the capacity of different drugs to block the response to capsaicin. Clonidine (10(-7) M to 10(-5) M), morphine (10(-6) M), aspirin (10(-3) M), ketanserin (10(-8) M) and (+/)- CP 96,345 (10(-6) M), an antagonist of neurokinin NK1 receptor, completely prevented the effects of capsaicin on the Kf,c. In contrast, terfenadine (10(-7)) together with cimetidine (10(-5) M) had no protective effect against capsaicin. It was concluded that capsaicin-induced pulmonary oedema was due to an increase in the capillary filtration coefficient and not to hemodynamic changes. This alteration in the endothelium permeability is mediated by the release of endogenous peptides from C-fibers upon the action of capsaicin and subsequent activation of NK1 receptors, probably by substance P. Moreover, 5-hydroxytryptamine receptors and arachidonic acid derivates are also involved in this reaction [less ▲]

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See detailn < 2 Allowed Transitions in Neutral Sulfur within in the Visible and Infrared Spectral Ranges
Biémont, Emile ULg; Quinet, Pascal ULg; Zeippen, C. J.

in Astronomy and Astrophysics. Supplement Series (1993), 102

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See detailTests simples pour le diagnostic présumé des Escherichia coli isolées principalement chez les bovins et productrices des cytotoxines nécrosantes (CNF)
Pohl, P.; Oswald, E.; Van Robaeys, G. et al

in Annales de Médecine Vétérinaire (1993), 137

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See detailHet Craeckhuys van de Bijloke in Gent, dendrochronologische analyse van houtmonsters
Hoffsummer, Patrick ULg; Houbrechts, David

in Stadsarcheologie (1993), 17(4), 24-29

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See detailSpelling en spellingverandering : een slingerbeweging in de tijd
Vromans, Joseph ULg

in Nederlands van Nu (1993), 41

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See detailCharacterization of the negative regulatory protein PHO80 involved in transcriptional regulation of PHO5 in Saccharomyces cerevisiae
Jacqmin, S.; Gilliquet, V.; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1993), 101

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See detailNeurotransmitter phenotype plasticity in adult dorsal root ganglia neurons
Moonen, Gustave ULg; Delrée, P.; Martin, Didier ULg et al

in Restorative Neurology & Neuroscience (1993), 5

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See detailAn overview of the kinetic parameters of class B beta-lactamases.
Felici, A; Amicosante, G; Oratore, A et al

in Biochemical Journal (1993), 291 ( Pt 1)

The catalytic properties of three class B beta-lactamases (from Pseudomonas maltophilia, Aeromonas hydrophila and Bacillus cereus) were studied and compared with those of the Bacteroides fragilis enzyme ... [more ▼]

The catalytic properties of three class B beta-lactamases (from Pseudomonas maltophilia, Aeromonas hydrophila and Bacillus cereus) were studied and compared with those of the Bacteroides fragilis enzyme. The A. hydrophila beta-lactamase exhibited a unique specificity profile and could be considered as a rather specific 'carbapenemase'. No relationships were found between sequence similarities and catalytic properties. The problem of the repartition of class B beta-lactamases into sub-classes is discussed. Improved purification methods were devised for the P. maltophilia and A. hydrophila beta-lactamases including, for the latter enzyme, a very efficient affinity chromatography step on a Zn(2+)-chelate column. [less ▲]

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See detailLa didactique universitaire : des méthodes et techniques à la redéfinition des objectifs
Merenne-Schoumaker, Bernadette ULg

in Education-Formation (1993), (232), 25-32

Courte réflexion sur la pédagogie universitaire portant à la fois sur les méthode set techniques et les objectifs de l'enseignement

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See detailBeam-laser lifetime measurements for low-lying levels in Cr II
Pinnington, E. H.; Ji, Q.; Guo, B. et al

in Canadian Journal of Physics (1993), 71

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See detailLa saisie électronique des données en forêt : réalités et perspectives
Rondeux, Jacques ULg

in Revue Forestière Française (1993), 45(n° sp), 20-26

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See detailDe Dakconstructie van de Karmelietenkerk, eerste dendrochronologische analyse
Hoffsummer, Patrick ULg; Houbrechts, David

in Stadsarcheologie (1993), 17(2), 29-34

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See detailMesurer les compétences en lecture: Apports et limites d'une enquête internationale
Lafontaine, Dominique ULg

in Lettre de la DFLM (La) (1993), 12

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See detailAccurate f-values of Astrophysical Interest in neutral Carbon
Hibbert, A.; Biémont, Emile ULg; Godefroid, M. et al

in Astronomy and Astrophysics. Supplement Series (1993), 99

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See detailLes aquifères crayeux en Belgique
Dassargues, Alain ULg; Monjoie, Albéric ULg

in Hydrogéologie (1993), (2), 135-145

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See detailAnalyse de la viande de poulet par spectroscopie infrarouge proche.
Sindic, Marianne ULg; Chevalier, Olivier; Dardenne, Pierre et al

in Viandes et Produits Carnés (1993), 14(4),

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See detailLes cellules ECL et leurs récepteurs: rôle physiologique et intérêt physiopathologique
Belaiche, Jacques ULg; Delwaide, Jean ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (1993), 56(3-4, May-Aug), 235-44

The enterochromaffin-like (ECL) cells represent the predominating endocrine cell population in the oxyntic mucosa of the stomach. They are under the influence of gastrin. Recently, a histamine production ... [more ▼]

The enterochromaffin-like (ECL) cells represent the predominating endocrine cell population in the oxyntic mucosa of the stomach. They are under the influence of gastrin. Recently, a histamine production was shown within the secretory granules of ECL cells. ECL cells appear to play a crucial role in the physiology of gastric acid secretion. There are many unknowns concerning the intervention of other trophic factors in addition to gastrin and concerning the receptors located on the cells. ECL cell hyperplasia is a well documented consequence of hypergastrinemia. The latter can result from a gastrinoma or from a reduction of gastric acid secretion related to pernicious anemia or to long-term treatment with antisecretory drugs. [less ▲]

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See detailLaparoscopy, urology, and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailLa production des noms propres
Brédart, Serge ULg

in Revue de Neuropsychologie (1993), 3

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See detailSomatosensory potentials in dogs suffering naturally-acquired thoraco-lumbar spinal cord disease
Poncelet, Luc; Michaux, Ch.; Balligand, Marc ULg

in American Journal of Veterinary Research (1993)

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See detailLes auteurs latins et les langues étrangères
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1993), 52

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See detailL’Iynge dans le discours mythique et les procédures magiques
Pirenne-Delforge, Vinciane ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1993), 6

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See detailStereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes
Pirotte, Bernard ULg; Felekidis, Apostolos ULg; Fontaine, M. et al

in Tetrahedron Letters (1993), 34

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See detailEffects of Age and Indomethacin on Response and Sensitivity of Pulmonary Artery to Phenylephrine and to Histamine in Pigs
Gustin, Pascal ULg; Ansay, Michel; Advenier, C.

in Journal of Veterinary Pharmacology & Therapeutics (1993), 16(2), 207-213

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and ... [more ▼]

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and arachidonic acid derivatives were also studied by incubating the blood-vessels with indomethacin. Potency (pD2 values) and maximal effects (Emaxx) recorded in 5-week-old piglets (group I, n= 5) with phenylephrine [5.71 ± 0.17 and 0.76 ± 0.22 g/mg of dry tissue respectively (mean ± SEM)] were similar to values found in 12-week-old animals (group 2, n = 5) (5.49 ± 0.30 and 1.06 ± 0.27 g/mg of dry tissue respectively). The sensitivity and responsiveness of tissues to this agonist were significantly reduced in 26-week-old mature pigs (group 3, n = 6) as indicated by the decrease in pD2 (3.91 ± 0.23; P < 0.01) and Emax (0.27 ± 0.13 g/mg of dry tissue; P < 0.05) values observed in this group. Histamine (10_3M)-induced maximal responses (Emax) were significantly higher in group 2 (2.23 ± 0.49 g/mg) than in group 1 (0.85 ± 0.11 g/mg; P < 0.05) and in group 3 (0.48 ± 0.10 g/mg; P < 0.01). In 5-week-old animals, indomethacin (3.10˜5M) significantly (P < 0.05) shifted the concentration-response curve to phenylephrine to the right (0.28 log. units) and depressed contractions to this drug as shown by the significant decrease of 39.5% (P < 0.05) in Emax. This cyclo-oxygenase inhibitor had no effect in other groups. These data indicate that phenylephrine is a potent and effective vasoconstrictor agent for the main pulmonary arteries in 5-week-old piglets and that alpha-1-adrenergic-induced contractions are enhanced by cyclo-oxygenase products. These findings can be related with the high reactivity of pulmonary vascular smooth muscles in these animals [less ▲]

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See detailL'histoire de Méléagre : plaidoyer pour une analyse de l'ensemble du mythe
Renaud, Jean-Michel ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1993), 6

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See detailSmall Bowel Enema and Diagnosis of Chronic Nonischemic Disturbance of Superior Mesenteric Venous Blood Flow
Boverie, J. H.; COUNET, D.; Meunier, Paul ULg et al

in Abdominal Imaging (1993), 18(3), 265-70

Chronic nonischemic disturbance of mesenteric venous blood flow is reported in 11 patients with a mean age of 19 years. This entity, rarely discussed in the literature, is different from acute thrombosis ... [more ▼]

Chronic nonischemic disturbance of mesenteric venous blood flow is reported in 11 patients with a mean age of 19 years. This entity, rarely discussed in the literature, is different from acute thrombosis and chronic thrombotic forms with portal hypertension or hypercoagulopathy. In eight patients this syndrome was secondary to organic lesions of different origin: mesenteric vein squeezed by fibrous bands or an abnormal jejunal artery (four cases), lymphoma involving the distal superior mesenteric veins (three cases), hemangioma causing microthrombi (one case). In three patients no etiology or predisposing factor was found. All patients presented with rectal hemorrhage. Small bowel enema showed a constant pattern in 11 patients: small nodules, modified by compression or peristalsis, involving the mesenteric border of the jejunoileal segment, and associated with thick, straight but regular folds. Mesenteric varices were suspected and led to angiographic studies which were normal in three cases, confirmed varices in eight cases, and thrombosis in four cases. Laparotomy was normal in three cases and established the etiological diagnosis in eight cases. Varices were shown in six cases. Arteriography and laparotomy were unable to reach a complete diagnosis. [less ▲]

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See detailLa collaboration entre les CPAS et autres institutions d'Aide Sociale
Gavray, Claire ULg; Huvelle, P.

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1993), 1-2

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