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See detailBon anniversaire. Compte rendu de la Xe Table Ronde ‘Informatique et Égyptologie, Bordeaux, 1994’
Winand, Jean ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1994), 41

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See detailOptimisation du plan parcellaire d'une exploitation agricole: une application de la theorie des graphes.
Dupont, Pascal ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(3),

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See detailPropriétés antifongiques de la microflore sporulée du netetu.
N'dir, B.; Hbid, Ch.; Cornelius, C. et al

in Cahiers Agricultures (1994), 3

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See detailModulatory Effect of Neuropeptide Y on Acetylcholine-Induced Oedema and Vasoconstriction in Isolated Perfused Lungs of Rabbit
Delaunois, Annie ULg; Gustin, Pascal ULg; Dessy-Doize, C. et al

in British Journal of Pharmacology (1994), 113(3), 973-81

1. The modulatory role of neuropeptide Y (NPY) on pulmonary oedema induced by acetylcholine and capsaicin was investigated. The effects of NPY on the haemodynamic response to acetylcholine, phenylephrine ... [more ▼]

1. The modulatory role of neuropeptide Y (NPY) on pulmonary oedema induced by acetylcholine and capsaicin was investigated. The effects of NPY on the haemodynamic response to acetylcholine, phenylephrine and substance P were also investigated. 2. Isolated, ventilated, exsanguinated lungs of the rabbit were perfused with a constant flow of recirculating blood-free perfusate. The double/arterial/venous occlusion method was used to partition the total pressure gradient (delta Pt) into four components: the arterial gradient (delta Pa), the pre- and post-capillary gradients (respectively delta Pa' and delta Pv') and the venous pressure gradient (delta Pv). Endothelial permeability was evaluated by measuring the capillary filtration coefficient (Kf,c). 3. Acetylcholine (10(-8) M to 10(-4) M) and substance P (SP, 10(-10) M to 10(-6) M) induced a concentration-dependent increase in the Kf,c. Capsaicin (10(-4) M) and 5-hydroxytryptamine (5-HT) (10(-4) M) also increased this parameter. NPY (10(-8) M) completely inhibited the effects of acetylcholine and capsaicin on the Kf,c, without preventing the effects of substance P and 5-HT. 4. Acetylcholine induced concentration-dependent vasoconstriction in the precapillary segment. The effect was inhibited by NPY and aspirin, an inhibitor of cyclo-oxygenase, while ketanserin, a 5-HT2 receptor antagonist, and SR140333, a new NK1 antagonist, had no protective effect. Phenylephrine increased delta Pa at high concentration, an effect also inhibited by NPY and aspirin. Substance P had no significant haemodynamic effect. When injected together with NPY, substance P (10(-6) M) induced a significant increase in the total pressure gradient.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailBacillus subtilis as a biopesticide : biochemical and technological aspects
Thonart, Philippe ULg; Heuze, V.; Destain, Jacqueline ULg et al

in Progress in biotechnology (1994), 9

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See detailParametric Cubic Equations For Modeling Moldboard Plow Surfaces
Ravonison, Nm.; Destain, Marie-France ULg

in Soil & Tillage Research (1994), 31(4), 363-373

Mouldboard shape identification is needed to compare and analyse the performance of different plough bottoms. The paper presents a method for describing an existing mouldboard mathematically. The ... [more ▼]

Mouldboard shape identification is needed to compare and analyse the performance of different plough bottoms. The paper presents a method for describing an existing mouldboard mathematically. The technique used is based on a Bezier form of three dimensional parametric cubics and it focuses on an algorithm to improve the efficiency of approximation of a theoretical surface and the actual one. The method is well suited to describing mouldboard designs. [less ▲]

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See detailPlasmids for heavy metal resistance in Alcaligenes eutrophus CH34: Mechanisms and applications
Collard, Jean-Marc; Corbisier, Philippe; Diels, Ludo et al

in FEMS Microbiology Reviews (1994), 14

Alcaligenes eutrophus CH34 is the main representative of a group of strongly related strains (mostly facultative chemolithotrophs) that are well adapted to environments containing high levels of heavy ... [more ▼]

Alcaligenes eutrophus CH34 is the main representative of a group of strongly related strains (mostly facultative chemolithotrophs) that are well adapted to environments containing high levels of heavy metals. It harbors the megaplasmids pMOL28 and pMOL30 which carry resistance determinants to Co2+, Ni2+, CrO42-, Hg2+, Tl+, Cd2+, Cu2+ and Zn2+. Among the best characterized determinants are the cnr operon (resistance to Co, Ni) an pMOL28 and the czc operon on pMOL30 (resistance to Co, Cd and Zn). Although the two systems reveal a significant degree of amino acid similarity in the structural genes, the regulation of the operons is different. The resistance mechanism in both cases is based on efflux. The efflux mechanism leads to a pH increase outside of the cytoplasmic membrane. Metals are sequestered from the external medium through the bioprecipitation of metal carbonates formed in the saturated zone around the cell. This latter phenomenon can be exploited in bioreactors designed to remove metals from effluents. The bacteria are immobilized on composite membranes in a continuous tubular membrane reactor (CTMR). The effluent continuously circulates through the intertubular space, while the external surface of the tubes is in contact with the growth medium. Metal crystals are eventually removed by the effluent stream and collected on a glass bead column. The system has been applied to effluents containing Cd, Zn, Co, Ni and Cu. By introducing catabolic plasmids involved in the aerobic degradation of PCBs and 2,4-D into metal-resistant A. eutrophus strains, the application range was widened to include effluents polluted with both organic and inorganic substances. Biosensors have been developed which are based on the fusion of genes induced by metals to a reporter system, the lux operon of Vibrio fischeri. Bacterial luciferases produce light through the oxidation of fatty aldehydes. The gene fusions are useful both for the study of regulatory genes and for the determination of heavy metal concentrations in the environment. [less ▲]

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See detailMolecular Analysis Of The Ycr-242 Gene Encoding The Putative Mitochondrial Asparaginyl-Transfer-Rna Synthetase From Saccharomyces-Cerevisiae
Landrieu, I.; Vandenbol, Micheline ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailThe mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.
Wilkin, J M; Dubus, Alice ULg; Joris, Bernard ULg et al

in Biochemical Journal (1994), 301 ( Pt 2)

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the ... [more ▼]

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the active-site cavity. Thr299 corresponds to the second residue of the Lys-Thr(Ser)-Gly triad, highly conserved in active-site beta-lactamases and penicillin-binding proteins (PBPs). Modification of Thr301 resulted only in minor alterations of the catalytic and penicillin-binding properties of the enzyme. No selective decrease of the rate of acylation was observed for any particular class of compounds. By contrast, the loss of the hydroxy group of the residue in position 299 yielded a seriously impaired enzyme. The rates of inactivation by penicillins were decreased 30-50-fold, whereas the reactions with cephalosporins were even more affected. The efficiency of hydrolysis against the peptide substrate was also seriously decreased. More surprisingly, the mutant was completely unable to catalyse transpeptidation reactions. The conservation of an hydroxylated residue in this position in PBPs is thus easily explained by these results. [less ▲]

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See detailComplete Dna-Sequence Of Yeast Chromosome-Xi
Dujon, Bernard; Esteban, Pf.; Fernandes, L. et al

in Nature (1994), 369(6479),

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See detailFollicular dendritic cells: whose children?
Heinen, Ernst ULg; Bosseloir, A.

in Immunology Today (1994), 15(5), 201-4

At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological ... [more ▼]

At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological conditions such as lymphoproliferative diseases and AIDS. Here, Ernst Heinen and Alain Bosseloir report on this fascinating field. [less ▲]

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See detailUn affranchi trop discret? : A propos des lignes 13-19 du P. Matr. Daris 2
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1994), LXIX(137), 127-131

Born of manumitted parents, Sarapion introduice himself as a freeborn though he too is a freedman. Observations on the way he got a patch of land and on the affective and sexual life of the slaves.

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See detailEvaluation du débit sanguin lors de contractions volontaires et évoquées électriquement
Vanderthommen, Marc ULg; Depresseux, J.C.; BAUVIR, Philippe ULg et al

in Kiné 2000 (1994), 5

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See detailReduction of the acute bioavailability of metformin by the alpha-glucosidase inhibitor acarbose in normal man.
Scheen, André ULg; de Magalhaes, A. C.; Salvatore, T. et al

in European Journal of Clinical Investigation (1994), 24 Suppl 3

In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy ... [more ▼]

In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy young male volunteers was randomly allocated during two consecutive 7 day periods to either acarbose (days 1-3: 3 x 50 mg day-1; days 4-7: 3 x 100 mg day-1) or placebo. At day 7 and 14 of the study, the overnight-fasted subjects ingested 1000 mg metformin with the first bite of a standardized breakfast (500 kcal; 60 g carbohydrates) and together with either placebo or 100 mg acarbose. Acarbose significantly (P < 0.05) reduced the meal-induced increase in blood glucose and plasma insulin levels. Acarbose induced a significant (P < 0.05) reduction in early (90, 120, 180 min) serum levels, peak concentrations (Cmax: 1.22 +/- 0.14 vs. 1.87 +/- 0.60 mg l-1) and area under the curve of metformin (AUC 0-540 min: 423 +/- 55 vs. 652 +/- 55 mg min l-1), but did not diminish its 24 h urinary excretion. In conclusion, acarbose significantly reduces the acute bioavailability of metformin in normal subjects. [less ▲]

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See detailL'évaluation dans le domaine de l'éducation : tendances
de Landsheere, Gilbert ULg

in Orientation Scolaire et Professionnelle (L') [=OSP] (1994), 23(1), 59-77

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See detailEffects of immunization against somatostatin on growth performances and growth hormone - insulin-like growth factor I and insulin plasma levels in young bulls.
Renaville, Robert ULg; Sneyers, M.; Massart, Serge et al

in Zootecnica e Nutrizione Animale (1994), 20(4),

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See detailDistribution of plankton parameters in the north eastern North Sea in relation to vertical physical structures
Veeschkens, Christine; Belkhiria, Sami; Goffart, Anne ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 65-88

See pdf file in attachment

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See detailAnalysis by in Situ Hybridization of Cytokine Mrnas Expression in Thymic Nurse Cells
Deman, J.; Humblet, Chantal ULg; Martin, M. T. et al

in Advances in Experimental Medicine and Biology (1994), 355

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See detailAssessment of the new immunological test Hemoblot for detecting occult blood in faeces
Jeanson, Antoinette; Jamart, J.; Maisin, J. M. et al

in European Journal of Cancer Prevention (1994), 3(5), 407-412

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and ... [more ▼]

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and with a guaiac test (Hemoccult II, SmithKline Diagnostics). The analytical sensitivity of Hemoblot is 0.15 mg haemoglobin/g faeces and the test is specific for human haemoglobin. In addition, 135 symptomatic patients who had to undergo a colonoscopy were tested using the three tests. Two criteria were considered for the analysis: (1) the blood criterion: any pathology likely to cause colorectal or other bleeding; and (2) the precancerous-cancerous criterion: the pathology being either a colorectal polyp > 0.5 cm or a colorectal cancer. Considering both criteria, the sensitivity of Hemoblot was significantly higher than the sensitivity of Hemoccult: 38% and 23%, respectively, for the blood criterion; and 54% and 29% for the precancerous-cancerous criterion. Sensitivity and specificity did not differ statistically between Hemoblot and HemeSelect but Hemoblot was faster and simpler to perform. It could be widely used in mass screening. [less ▲]

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See detailTaqi Restriction-Fragment-Length-Polymorphisms For Growth-Hormone In Bovine Breeds And Their Association With Quantitative Traits
Sneyers, M.; Renaville, Robert ULg; Falaki, M. et al

in Growth Regulation (1994), 4(3),

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See detailAbnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.
Van Cauter, E. V.; Polonsky, K. S.; Blackman, J. D. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 79(6), 1797-805

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep ... [more ▼]

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep, 28 h of continuous wakefulness, and 8 h of daytime sleep. Blood samples were collected at 20-min intervals to assay glucose, insulin, C-peptide, cortisol, and GH. Sleep was polygraphically monitored. Abnormal temporal profiles of glucose regulation were observed during wakefulness and sleep in obese subjects. During daytime hours, the normal profile of glucose tolerance was reversed, as an improvement, rather than a deterioration, was observed from morning to late evening. This reversal of the daytime pattern appeared to be caused by a dual defect in glucose regulation during the previous night. Indeed, during early sleep, GH secretion was markedly reduced, and the nocturnal rises of glucose and insulin secretion were dampened. During late sleep, obese subjects failed to suppress insulin secretion and plasma glucose, resulting in high morning levels. Comparisons of metabolic and hormonal patterns during nocturnal and daytime sleep suggest that the failure to suppress insulin secretion in late sleep may reflect a relative insensitivity of the beta-cell to acute inhibitory effects of cortisol in addition to insulin resistance. [less ▲]

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See detailBovine Leukaemia Virus: biology and mode of transformation
Burny, A.; Willems, Luc ULg; Callebaut, I. et al

in Viruses and Cancer, Cambridge University Press (1994)

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See detailDetection des molecules responsables de l'activite biocide des feuilles de Boscia senegalensis (Pers.) Lam ex Poir. par echantillonage d'espace de tete et spectrometrie de masse couplee a la chromatographie en phase gazeuse.
Lognay, Georges ULg; Marlier, M.; Seck, D. et al

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(1),

Des échantillons de feuilles de Boscia senegalensis (Prns.) I.ev ex Porn. ont été tnaintenus dans des conditions contrôlées sous un flux d'hélium, à l'intérieur d'une.platine de désorption thermique ... [more ▼]

Des échantillons de feuilles de Boscia senegalensis (Prns.) I.ev ex Porn. ont été tnaintenus dans des conditions contrôlées sous un flux d'hélium, à l'intérieur d'une.platine de désorption thermique directement connectée à un GC-MS. A côté du trans-2-hexénal, responsable de la note "verte" des feuilles, l'isothiocyanate de méthyle et le cyanure de méthyle (acétonitrile) ont été détectés. Ces deux produits se sont formés par dégradation enzymatique in situ d'un précurseur, la glucocapparine. Ils ont été caractérisés par leur spectre de masse. La libération de cyanure de méthyle à partir d'échantillons biologiques est expliquée. [less ▲]

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See detailComparison of 125I and 3H testosterone radioimmunoassay methods in bovine serum
Miklos, M.; Renaville, Robert ULg; Tözser, J.

in Klin Kiserl Lab Med (1994), 22

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See detailAspects redistributifs de l'endettement public
Pestieau, Pierre ULg; Perelman, Sergio ULg

in La dette publique en Belgique (1994)

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See detailErythropoietic activity and iron metabolism in autologous blood donors during recombinant human erythropoietin therapy.
Biesma, D. H.; Van de Wiel, A.; Beguin, Yves ULg et al

in European Journal of Clinical Investigation (1994), 24(6), 426-32

The use of recombinant human erythropoietin (rhEPO) to intensify the erythropoietic response in autologous donors may reduce homologous blood requirement. We studied the effect of subcutaneous rhEPO (500 ... [more ▼]

The use of recombinant human erythropoietin (rhEPO) to intensify the erythropoietic response in autologous donors may reduce homologous blood requirement. We studied the effect of subcutaneous rhEPO (500 U kg-1 body weight twice weekly during a 3 week period) on variables of erythropoiesis and iron metabolism in 62 autologous blood donors, of whom 32 received rhEPO (epo group) and 30 did not (control group). Patients donated only 2 units of blood and received oral iron in order to restrict phlebotomy-induced decrease of iron stores. Pre-phlebotomy haemoglobin concentration (14.0 +/- 0.8 g dl-1) was completely regenerated in the epo group at surgery (13.7 +/- 1.3 g dl-1); haemoglobin concentration in the control group fell from 13.5 +/- 1.4 g dl-1 to 11.6 +/- 1.4 g dl-1 after the phlebotomies and did not improve during the pre-operative phase. Total erythropoietic activity expressed as serum transferrin receptor concentration (sTfR) showed a 4-fold increase from 3.8 +/- 0.9 micrograms ml-1 to 14.9 +/- 4.8 micrograms ml-1 in the epo group. Effective erythropoietic activity measured by absolute reticulocyte count, however, declined after the fourth rhEPO injection in the epo group. Serum ferritin was lower in the epo group, but no differences in serum iron, transferrin concentration and transferrin saturation were observed between the groups. A marked increase in free erythrocyte protoporphyrin (FEP) was observed in the epo group, whereas FEP levels in the controls remained within normal ranges. Despite oral iron supplementation and the limited number of phlebotomies, the effect of rhEPO therapy in autologous donors is restricted by iron depletion. [less ▲]

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See detailGreffes de moelle dans les hémoglobinopathies
Beguin, Yves ULg

in Mini Acta (1994), 26

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See detailLes fleurs pâles du souvenir... Sur Guillaume Lekeu
Pirenne, Christophe ULg; Vendrix, Philippe ULg

in La Vie Wallonne (1994), 110

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See detailUse of recombinant human erythropoietin after bone marrow transplantation in pediatric patients with acute leukemia: effect on erythroid repopulation in autologous versus allogeneic transplants.
Locatelli, F.; Zecca, M.; Pedrazzoli, P. et al

in Bone Marrow Transplantation (1994), 13(4), 403-10

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) in children undergoing allogeneic or mafosfamide-purged autologous BMT for ALL or AML. rHuEPO was administered ... [more ▼]

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) in children undergoing allogeneic or mafosfamide-purged autologous BMT for ALL or AML. rHuEPO was administered intravenously at a dose of 75 U/kg/day for 30 days after transplant. Ten rHuEPO-treated patients receiving allogeneic BMT and 10 given autologous BMT were compared with 15 allogeneic and 10 autologous historical controls. Endogenous EPO production was appropriate for the degree of anemia after autologous BMT. In these patients, rHuEPO did not accelerate erythroid repopulation and did not modify transfusion requirements. With allogeneic BMT, erythroid marrow activity increased faster in patients given rHuEPO than in controls and resulted in higher red cell production, the mean reticulocyte count on day +30 being 187 +/- 51 x 10(9)/l in treated patients versus 107 +/- 63 x 10(9)/l in controls (p < 0.01). The total number of RBC units administered was 1.7 +/- 1.3 in the rHuEPO group versus 5.1 +/- 3.0 in the control group (p < 0.001). The total number of platelet transfusions was 4.0 +/- 2.3 for patients given allogeneic BMT and receiving rHuEPO versus 8.4 +/- 6.8 for historical controls (p < 0.05) whereas it was similar in rHuEPO-treated and control autologous BMT patients.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailMaastricht in beweging. Enkele bedenkingen na het Belgisch voorzitterschap van de Europese Unie
Flore, Daniel ULg; Troosters, R.

in Panopticon : Tijdschrift voor Strafrecht, Criminologie en Forensisch Welzijnswerk (1994)

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See detailEffet différentiel d'un didacticiel d'apprentissage de l'orthographe selon le mode d'utilisation de l'ordinateur
Crahay, Marcel ULg; Huberman, M.

in Education et Recherche (1994), 16(3), 300-326

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See detailDo canine scalene and sternomastoid muscles play a role in breathing?
De Troyer, A.; Cappello, M.; Brichant, Jean-François ULg

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1994), 76(1), 242-52

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on ... [more ▼]

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on the electrical activity of these muscles in 18 supine anesthetized spontaneously breathing animals. The sternomastoids never showed any activity, and the scalenes showed some inspiratory activity during occlusion in only two animals. The adoption of the prone position and bilateral cervical vagotomy did not affect this pattern. Hypercapnia also did not elicit any sternomastoid activity and induced scalene inspiratory activity during occlusion in only four of nine animals. On microscopic examination, however, both muscles were found to contain large numbers of spindles, suggesting that they have the capacity to respond to stretch. In addition, with increases in inspiratory resistance, both the sternum and ribs were displaced in the caudal direction. As a result, the scalenes demonstrated a gradual inspiratory lengthening and the normal inspiratory lengthening of the sternomastoids was accentuated. Additional studies in three unanesthetized animals showed consistent activity in the scalene and sternomastoid muscles during movements of the trunk and neck but no activity during breathing, including occluded breathing. These observations thus indicate that the alpha-motoneurons of the scalene and sternomastoid muscles in the dog have very small central respiratory drive potentials with respect to their critical firing threshold. In this animal, these muscles do not have a significant respiratory function. [less ▲]

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See detailDistribution and Regulation of Estrogen-2-Hydroxylase in the Quail Brain
Balthazart, Jacques ULg; Stoop, R.; Foidart, Agnès ULg et al

in Brain Research Bulletin (1994), 35(4), 339-45

The anatomical distribution and endocrine regulation of the estrogen-2-hydroxylase activity were investigated in the brain of adult male and female Japanese quail. Significant levels of enzymatic activity ... [more ▼]

The anatomical distribution and endocrine regulation of the estrogen-2-hydroxylase activity were investigated in the brain of adult male and female Japanese quail. Significant levels of enzymatic activity were detected in all brain regions that were studied, but the highest levels were observed in preoptic and hypothalamic brain nuclei that are known to contain high levels of aromatase activity. These data are consistent with previous results suggesting that the placental aromatase is also responsible for the estrogen-2-hydroxylase activity. However, there is a marked sex difference and a control by T of aromatase activity in the quail brain, and no such difference in 2-hydroxylase activity could generally be detected except in the VMN. Further studies will be needed to know whether the previously published conclusions concerning the human placenta also apply to the brain. The present data are consistent with the idea that estrogens formed locally in the brain by testosterone aromatization could affect reproduction by interfering with the catecholaminergic transmission after being metabolized into catechol-estrogens. [less ▲]

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See detailThe Perturbed Tikhonov's Algorithm and Some of its Applications
Tossings, Patricia ULg

in RAIRO : Modélisation Mathématique et Analyse Numérique (Mathematical Modelling and Numerical Analysis) (1994), 28(2), 189-221

The proximal point algorithm has known these last years many developments connected with the expansion of the variational convergence theory. Motivated by this fact and inspired by the work of A. Tikhonov ... [more ▼]

The proximal point algorithm has known these last years many developments connected with the expansion of the variational convergence theory. Motivated by this fact and inspired by the work of A. Tikhonov and V. Arsénine in the context of convex optimization, we present a new algorithm for searching a zero of a maximal monotone operator on a real Hilbert space. We study the perturbed version of this algorithm and establish a critical comparison with the perturbed proximal point algorithm. We apply this new algorithm to convex optimization and to variational inclusions or, more particularly, to variational inequalities. [less ▲]

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See detailLe renouveau cosaque
Bachkatov, Nina ULg; Wilson, Andrew

in Transitions : Ex-Revue des Pays de L'est (1994), 35-1

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See detailControl of the Illegal Administration of Natural Steroid Hormones in the Plasma of Bulls and Heifers
Scippo, Marie-Louise ULg; Degand, Guy ULg; Duyckaerts, Anne et al

in Analyst (1994), 119(12), 2639-44

In the context of the control of the illegal administration of natural steroid hormones in cattle husbandry, an attempt was made to establish the decision levels for sex steroid hormones in the plasma of ... [more ▼]

In the context of the control of the illegal administration of natural steroid hormones in cattle husbandry, an attempt was made to establish the decision levels for sex steroid hormones in the plasma of adult cattle, taking into account the effect of the treatment. Bulls and heifers were treated with two injections, at a two week interval, of an estradiol-testosterone cocktail. Steroid hormone and biochemical precursor concentrations were measured in plasma samples by using specific radioimmunoassays, before and after the treatment. When the treatment significantly (p < 0.05) modified a hormone concentration, a decision level was established for that hormone concentration. At each decision level, a score was assigned that represented the percentage of treated animals detected when the decision limit was applied. For heifers, 17 beta-estradiol and testosterone concentrations in plasma, which increased after the treatment, are the best criteria to use to detect treated animals, with decision limits of 20 pg ml-1 and 125 pg ml-1, respectively. In the instance of bulls, both testosterone and steroid biochemical precursor concentrations decreased in the plasma after the treatment. We proposed decision limits of 1500 pg ml-1 and 28 pg ml-1 for testosterone and androstenedione concentrations, respectively, the bulls displaying concentrations below these limits being positive. We observed that the repetition of the injection increased the score of the decision limit. The scores for testosterone are 70%, 14d after the first injection and 100% 14 d after the second injection, and for androstenedione, these scores are 60 and 100%, respectively. [less ▲]

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See detailL'inventaire forestier wallon: un outil de developpement regional
Rondeux, Jacques ULg

in Wallonie (1994), 21(34), 3-8

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See detailSequence-Analysis Of A 40-Kb Dna Fragment From Chromosome-X Of Saccharomyces-Cerevisiae
Vandenbol, Micheline ULg; Bolle, Pa.; Dion, C. et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailLocalisation scintigraphique de tumeurs neuroendocrines et de leurs métastases par un analogue de la somatostatine: [111In-DTPA-d-phe1] octreotide
Beckers, Albert ULg; Pham, V. T.; Abs, R. et al

in Médecine & Chirurgie Digestives (1994), 23(3), 145-150

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See detailFunctional Sites Of The Bovine Leukemia-Virus Envelope Glycoproteins Using Structural And Immunological Data
Callebaut, I.; Mornon, Jp.; Burny, A. et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailModèles de cubage pour essences multi-tiges : application à des plantations d'acacia
Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Cahiers Agricultures (1994), 3(3), 189-194

Tree-volume equations were devised to estimate the volume of wood (excluding bark) of Acacia auriculiformis A. Cunn ex Benth fuelwood plantations in Zaïre. The tables give the total volume of stems and ... [more ▼]

Tree-volume equations were devised to estimate the volume of wood (excluding bark) of Acacia auriculiformis A. Cunn ex Benth fuelwood plantations in Zaïre. The tables give the total volume of stems and branches to an upper girth limit of 9 cm, together with the volumes according to the following classes of girth : 9-14, 15-44 and over 45 cm. Because this species has a high proportion of multiple-stem trees (which begin forking below the breast-height level), girth at 1.30 m is a relatively meaningless concept. Taking the extent of this variable in tree volume estimation into account, various expressions of girth were investigated. Instead of considering each stem girth individually, a "standardised" girth at 1.30 m (from ground level) was adopted. For any given tree, this corresponds to the quadratic sum of all girths measured at 1,30 m. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Bouwen met Staal (1994), n°117

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See detailEtude comparative de six systèmes d'immunodosage de la ferritine sérique au cours de maladies rhumatismales
Revenant, M. C.; Vernet, M.; Rymer, J. C. et al

in Eurobiologiste (L') (1994), XXVIII(2), 35-41

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See detailEffect of recombinant human erythropoietin on platelets in patients with anemia of renal failure: correlation of platelet count with erythropoietic activity and iron parameters.
Beguin, Yves ULg; Loo, Martine; R'Zik, Samir ULg et al

in European Journal of Haematology (1994), 53(5), 265-70

We examined the effect of treatment with rHuEpo on platelet counts in 61 hemodialysis patients and correlated them with changes in erythropoietic activity, iron status and inflammation. Platelets (10(9)/1 ... [more ▼]

We examined the effect of treatment with rHuEpo on platelet counts in 61 hemodialysis patients and correlated them with changes in erythropoietic activity, iron status and inflammation. Platelets (10(9)/1) increased from 220 +/- 80 to 245 +/- 102 after 14 days and stabilized at that level up to day 90 (p < 0.0001). The increment was similar in complete or partial responders but was not observed in failures. Serum transferrin receptor (sTfR, a measure of total erythropoiesis) and Het rose much more progressively, but relative platelet increments correlated with relative increases in sTfR and Hct. Relative platelet increments correlated inversely with relative changes of SeFe or transferrin saturation, but not with their absolute values, nor with baseline ferritin or its progressive decrease. Although baseline platelet count was 12% higher in patients with inflammation and correlated with serum haptoglobin, relative increases were similar in patients with or without inflammation. In conclusion, rHuEpo produced a clinically minor but consistent elevation of platelet counts. These modifications were not related primarily to modifications in iron stores, functional iron deficiency, or inflammation, but paralleled the expansion of erythropoietic activity. The results suggest that rHuEpo has a small positive effect on platelet production, but it cannot be ruled out that this could be partially mediated through functional iron deficiency. [less ▲]

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See detailPuissance maximale aérobie d’enfants en âge d’école primaire participant ou non à une leçon quotidienne d’activités physiques
Ledent, Maryse; Delfosse, Catherine; Cloes, Marc ULg et al

in Revue de l'Education Physique (1994), 34(2-3), 69-75

Plusieurs études indiquent que, chez l'adulte, il existe une relation significative entre la pratique d'activités physiques et sportives et la diminution des facteurs de risque, surtout cardiovasculaire ... [more ▼]

Plusieurs études indiquent que, chez l'adulte, il existe une relation significative entre la pratique d'activités physiques et sportives et la diminution des facteurs de risque, surtout cardiovasculaire. En particulier, l'endurance qui découle d'une pratique régulière d'activités modérés à intenses de répercute sur la condition du système cardiovasculaire et réduit significativement les risques de troubles cardiaques. ... [less ▲]

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See detailChloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content
Bettendorff, Lucien ULg; Hennuy, Benoît ULg; De Clerck, Anne et al

in Brain Research (1994), 652(1), 157-160

Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates ... [more ▼]

Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates, increased TTP content correlates with increased 36Cl- uptake. A hyperbolic relationship was obtained with a K0.5 of 0.27 nmol TTP/mg protein. In crude mitochondrial fractions from the brains of animals previously treated with thiamine or sulbutiamine, a positive correlation between 36Cl- uptake and TTP content was found. These results, together with other results previously obtained with the patch-clamp technique, suggest that TTP is an activator of chloride channels having a large unit conductance. [less ▲]

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See detailTechniques moleculaires de detection et d'identification des agents phytopathogenes.
Lepoivre, Philippe ULg; Kummert, J.; Colinet, D. et al

in Cahiers Agricultures (1994), 3(4),

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See detailCloning And Characterization Of Mn, A Human Tumor-Associated Protein With A Domain Homologous To Carbonic-Anhydrase And A Putative Helix-Loop-Helix Dna-Binding Segment
Pastorek, J.; Pastorekova, S.; Callebaut, I. et al

in Oncogene (1994), 9(10),

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See detailRock progressif et analyse musicale
Pirenne, Christophe ULg

in Art&Fact (1994), 13

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See detailChanges in glucose turnover parameters and improvement of glucose oxidation after 4-week magnesium administration in elderly noninsulin-dependent (type II) diabetic patients.
Paolisso, G.; Scheen, André ULg; Cozzolino, D. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 78(6), 1510-4

The aim of the present study was to investigate the effects of magnesium supplementation on glucose uptake and substrate oxidation in noninsulin-dependent (type II) diabetic patients. Nine elderly non ... [more ▼]

The aim of the present study was to investigate the effects of magnesium supplementation on glucose uptake and substrate oxidation in noninsulin-dependent (type II) diabetic patients. Nine elderly non-obese noninsulin-dependent (type II) diabetic patients, treated by diet only, participated in the study, which was designed as randomized, double blind, and cross-over. Each patient was followed up for a prestudy period of 3 weeks before inviting him/her to receive placebo or magnesium supplementation (15.8 mmol/day) for 4 weeks. At the end of each treatment period, a euglycemic hyperinsulinemic glucose clamp with simultaneous D-[3-3H]glucose infusion and indirect calorimetry was performed. Magnesium supplementation resulted in significantly increased plasma and erythrocyte magnesium levels, whereas body weight and fasting plasma glucose did not change. In the last 60 min of the glucose clamp, insulin-mediated glucose disappearance, total body glucose disposal (24.5 +/- 0.4 vs. 28.2 +/- 0.7 mumol/kg.min; P < 0.005), and glucose oxidation (13.0 +/- 0.4 vs. 16.3 +/- 0.8 mumol/kg.min; P < 0.01) were increased after chronic magnesium supplementation. Endogenous glucose production, nonoxidative glucose disposal, lipid and protein oxidation, and insulin MCR were not affected. In conclusion, a 4-week magnesium supplementation improves insulin sensitivity and glucose oxidation in the course of a euglycemic-hyperinsulinemic glucose clamp in noninsulin-dependent diabetic patients. Long term studies are needed to determine whether magnesium supplementation is useful in the management of type II diabetes. [less ▲]

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See detailMassive Ketonuria During Sedation with Propofol in a 12 Year Old Girl with Severe Head Trauma
Canivet, Jean-Luc ULg; Gustad, K.; Leclercq, P. et al

in Acta Anaesthesiologica Belgica (1994), 45(1), 19-22

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial ... [more ▼]

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial hypertension; as a part of our management protocol, glucose intake was restricted to 5 Kcal/h. After 18 hours of propofol infusion there was intense ketonuria (8+ by Ketostix) without any evidence of metabolic acidosis (pH, HCO3- and anion gap were within normal values). At this time, indirect calorimetry (Deltatrac) confirmed that energy expenditure was principally based on fat consumption (70% of energy expenditure). Lowering the propofol infusion rate and increasing glucose intake reduced fat consumption to 39% within 8 hours: at this time, Ketostix was negative for ketone bodies. This case illustrates a potential risk of ketonuria during prolonged sedation with propofol (a 10% solution of intralipid), particularly if glucose intake is restricted. Monitoring urinary ketone bodies is recommended under these circumstances. [less ▲]

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See detailEst-ce ainsi que les jeunes Belges lisent? Résultat d'une enquête internationale
Lafontaine, Dominique ULg; Lafontaine, Annette ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1994), 31(7), 31

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See detailRelationship between alpha 2-adrenergic function and suicidal behavior in depressed patients.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Psychiatry Research (1994), 52(2), 115-23

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible implication of the noradrenergic function. In the present study, we assessed the growth hormone response to clonidine, a selective alpha 2-adrenergic agonist, in 15 DSM-III-R major depressive inpatients with a history of suicide attempts, compared with 15 age- and gender-matched major depressive inpatients without a history of suicidal behavior. Mean (+/- SD) growth hormone peak responses to clonidine were significantly lower in the group of suicide attempters than in the control group: 2.93 +/- 3.01 ng/ml vs. 8.28 +/- 8.15 ng/ml. Therefore, these results suggest that a blunted growth hormone response to clonidine could be a biological correlate of suicidal behavior. [less ▲]

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See detailPump up the volume! Mogelijkheid en onmogelijkheid van het manifest in postmoderne tijden
Spinoy, Erik ULg

in De Zingende Zaag (1994), (24-25), 102-123

This article reflects on the fact that manifests are a predominantly modernist genre. In postmodern times, manifests can only reappear as simulations or parodies.

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See detailLe tamoxifene dans le traitement du cancer du sein
Charlier, Corinne ULg; Colin, Claude ULg; Merville, Marie-Paule ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(7), 751-6

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on ... [more ▼]

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on oral adjuvant therapy in the early stages of breast cancer. A significative regression of the tumour was observed in most cases. Moreover, recent epidemiological studies suggest that tamoxifen could prevent new contralateral primary tumours. The risk of the disease should thus be reduced by the prophylactic use of antioestrogens such as tamoxifen. Investigations using a variety of models have evaluated the effect of tamoxifen on tumour promotion and cell growth. Tamoxifen-induced growth inhibition is associated with major changes in biochemical events in cultured human breast cancer cells including cell proliferation or growth factor production. Growth inhibition of oestrogen-responsive human breast cancer cells is associated with an induced secretion of autoinhibitory polypeptides (TGF beta) and an antagonistic effect on the synthesis of proliferative proteins (TGF alpha,...). The first step in the mechanism of action of the drug is binding of tamoxifen to the oestrogen receptors. Development of resistance to tamoxifen treatment is a great problem in treatment of breast cancer patients and the mechanism of resistance will require further study: under the influence of the drug, tumours could become remodelled as selected subpopulations emerge resistant-tamoxifen. The fact that some breast cancers which are oestrogen receptor-negative respond to antioestrogen suggests that parallel but separate pathways for oestrogen and antioestrogen action may exist. This paper summarizes the results of the most recent studies concerning this promising drug. [less ▲]

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See detailStructure and orientation of apo B-100 peptides into a lipid bilayer.
Lins, Laurence ULg; Brasseur, Robert ULg; Rosseneu, M. et al

in Journal of Protein Chemistry (1994), 13(1), 77-88

Peptides corresponding to lipid binding domains of Apo B-100 were synthesized, purified, and incubated with dimyristoylphosphatidylcholine (DMPC) liposomes. The secondary structure of the apo B-100 ... [more ▼]

Peptides corresponding to lipid binding domains of Apo B-100 were synthesized, purified, and incubated with dimyristoylphosphatidylcholine (DMPC) liposomes. The secondary structure of the apo B-100 peptide-lipid complexes was evaluated by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Those peptides belonging to the hydrophobic "core" domain of apo B-100 when associated with phospholipids were rich in beta sheet structure; a predominant alpha helical conformation was shown to be associated with one peptide located in a surface region of apo B-100. IR dichroic spectra revealed, in the case of the "core" peptides, that the beta sheet component is the only oriented structure with respect to the phospholipid acyl chains. This orientation of the beta sheet was recently found in LDL particles after proteolytic digestion by trypsin (Goormaghtigh, E., Cabiaux, V., De Meutter, J., Rosseneu, M., and Ruysschaert, J. M., 1993, Biochemistry 32, 6104-6110). Altogether, the data suggest that beta sheet, present in a high proportion in the native apo B-100, is probably another protein structure in addition to the amphipathic helix which strongly interacts with the lipid outer layer surrounding the LDL particle. [less ▲]

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See detailUne contrefaçon liégeoise exemplaire : les Œuvres du philosophe bienfaisant (1764)
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1994), 265

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See detailTEMPERATURE-DEPENDENCE OF GROWTH, ENZYME-SECRETION AND ACTIVITY OF PSYCHROPHILIC ANTARCTIC BACTERIA
Feller, Georges ULg; Narinx, E.; Arpigny, J. L. et al

in Applied Microbiology & Biotechnology (1994), 41(4), 477-479

Five psychrophilic Antarctic bacteria have been selected for their capacity to secrete exoenzymes into culture medium. These strains are able to grow from 0 to about 25 degrees C. However, production of ... [more ▼]

Five psychrophilic Antarctic bacteria have been selected for their capacity to secrete exoenzymes into culture medium. These strains are able to grow from 0 to about 25 degrees C. However, production of lipase from Moraxella, alpha-amylase from Alteromonas haloplanctis, beta-lactamase from Psychrobacter immobilis and protease from Bacillus is maximal at temperatures close to that of their environment (-2 to 4 degrees C) and is strongly inhibited at higher temperatures. This thermal effect involves alterations in the secretory pathway in the upper range of temperatures, losses due to the enzyme thermal lability and in some cases to reduction in cell development. The apparent optimal activity temperature of these enzymes is between 30 and 40 degrees C, i.e. about 20 degrees C lower than that of their mesophilic counterparts. [less ▲]

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See detailLaparoscopic adrenalectomy in pheochromocytoma and Cushing's syndrome. Reflections about two case reports.
Meurisse, Michel ULg; Joris, Jean ULg; Hamoir, Etienne ULg et al

in Acta Chirurgica Belgica (1994), 94(6), 301-6

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open ... [more ▼]

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open method. In combination with intraoperative infusion of nicardipine, a calcium-channel blocker, the laparoscopic removal of a pheochromocytoma was performed safely and under stable conditions. In case of Cushing's syndrome, the laparoscopic approach reduces the problems related to poor healing. In all cases of laparoscopic adrenalectomy, this approach could offer the clear advantages of smaller incisions, reduced postoperative pain and incisional discomfort as well as complications related to large and invasive procedure and finally allows quicker recovery. Moreover, conversion to open surgery remains always possible, if needed. [less ▲]

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See detailEtude des relations entre les microstructures obtenues par vieillissement isotherme et le comportement mécanique (fatigue, résilience) dans des alliages Zn-Al et Zn-Al-Cu
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Wegria, J.

in Revue de Métallurgie [=Revue de Métallurgie. Cahiers d'Informations Techniques] (1994), 91[5]

L’article présenté établit une corrélation entre le comportement mécanique (fluage, résilience) et les microstructures qui apparaissent au cours d’un traitement thermique isotherme (100 ou 250 °C) dans ... [more ▼]

L’article présenté établit une corrélation entre le comportement mécanique (fluage, résilience) et les microstructures qui apparaissent au cours d’un traitement thermique isotherme (100 ou 250 °C) dans des alliages Zn-Al et Zn-Al-Cu1. Le but est de mettre en évidence l’intérêt pratique des modifications structurales obtenues. On observe un meilleur résultat pour des échantillons vieillis pendant une semaine environ. La température de traitement la plus favorable est 250 °C. De plus, les alliages contenant du cuivre possèdent un meilleur comportement que les alliages binaires Zn-Al. [less ▲]

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See detailMétaux lourds et isotopes stables du carbone dans la matière particulaire: distribution sur le plateau continental nord-ouest européen
Dauby, Patrick ULg; Mosora, Fiorentina; Frankignoulle, Michel et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63

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See detailIsolation of the missing 5-end of the encoding region of the bovine leukemia virus cell receptor gene.
Ban, J.; Truong, A. T.; Horion, B. et al

in Archives of Virology (1994), 138(3-4),

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See detailAcute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study.
Dahchour, Abdelkhader; Quertemont, Etienne ULg; De Witte, Philippe

in Alcohol & Alcoholism (1994), 29(5), 485-7

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain ... [more ▼]

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain nucleus accumbens were studied by the microdialysis technique coupled to HPLC-EC detection. Levels of GLU and GABA were not affected by ethanol, whereas those of TAU were increased by doses of the drug of 2-3 g/kg. [less ▲]

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See detailHématome extradural cervical spontané de la femme enceinte
Mahieu, X.; Kridelka, Frédéric ULg; Pintiaux, Axelle ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(1), 99-102

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The ... [more ▼]

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The patient underwent first a caesarean and thereafter a prompt spinal surgical decompression. Complete sensory-motor recovery occurred after 48 hours. Differential diagnosis of cord compression, etiology of bleeding, conditions of recovery after surgery are discussed. [less ▲]

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See detailLes disparités et les dynamiques territoriales. Introduction méthodologique
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (1994), (30), 5-14

This paper considers three kinds of methodological problems in the field of territorial dynamics and disparities. First of all, the definition of the concepts of disparity, dynamics and territory ... [more ▼]

This paper considers three kinds of methodological problems in the field of territorial dynamics and disparities. First of all, the definition of the concepts of disparity, dynamics and territory; secondly, the choice of spatial analysis levels, temporal limits and indicators and finally research into explanations. These are always very complicated and pratical despite the contribution of the major regional development theories and the new inquiries of regional science in the field of perceptions, networks and actors' roll. [less ▲]

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See detailLa formation des agents de santé scolaire dans le cadre du programme "Je mange bien à l'école"
Vandoorne, Chantal ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), (3),

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See detailGestion d'un épisode de peste porcine classique en Belgique
Vanthemsche, P.; Saegerman, Claude ULg

in Epidémiologie et Santé Animale (1994), 26

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See detailEtude épidémiologique de la toxoplasmose chez les femmes enceintes à Amiens (Picardie). Nécessité d'une enquête nationale
Carme, Bernard; Lenne, Evelyne; Tirard, Véronique et al

in Médecine et Maladies Infectieuses (1994), 24

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives ... [more ▼]

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives vis à vis de cette parasitose. Cette étude a permis de mettre en évidence la bonne connaissance des mesures préventives vis à vis de la toxoplasmose chez les femmes non immunes. Ceci a permis également de préciser les données épidémiologiques de la toxoplasmose à Amiens. Le choix d'un protocole incluant les femmes au moment de l'accouchement pourrait être complété par celui de femmes en début de grosesse pour éviter d'exclure les interruptions de grossesse. Cette étude devrait déboucher sur une enquête nationale qui permettrait de préciser l'épidémiolgoie de la toxoplasmose en France. [less ▲]

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See detailLe financement au niveau communal
Jurion, Bernard ULg

in Mouvement communal, Union des Villes et des Communes de Belgique (1994)

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See detailCalcitropic effect of recombinant prolactins in Oreochromis mossambicus
Flik, G.; Rentier-Delrue, Françoise ULg; Wendelaar-Bonga, S. E.

in The American Physiological Society (1994)

Homologous recombinant tilapia prolactins 1 and 2 were tested for calcitropic activity in tilapia Oreochromis mossambicus. Injection of both PRLs induced hypercalcemia that resulted for an enhanced ... [more ▼]

Homologous recombinant tilapia prolactins 1 and 2 were tested for calcitropic activity in tilapia Oreochromis mossambicus. Injection of both PRLs induced hypercalcemia that resulted for an enhanced calcium influx via the gills and a decreased calcium efflux. Both PRLs increased the density of the Ca2+-transporting Ca2+-adenosinetriphosphatase in a plasma membrane preparation of the branchial epithelium. Dose-response studies demonstrated that the PRL-1 was roughly twofold more potent than PRL2 in inducing hypercalcemia, in enhacing basal levels of cortisol and in stimulating opercular ionocyte density. But both PRL were equipotent in stimulating the dermal mucocyte frequency. [less ▲]

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See detailPeritoneal endometriosis: two-dimensional and three-dimensional evaluation of typical and subtle lesions.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise

in Annals of the New York Academy of Sciences (1994), 734

Endometriosis most commonly affects the pelvic peritoneum close to the ovaries, including the uterosacral ligaments, the ovarian fossa peritoneum, and the perito- neum of the cul-de-sac. The increased ... [more ▼]

Endometriosis most commonly affects the pelvic peritoneum close to the ovaries, including the uterosacral ligaments, the ovarian fossa peritoneum, and the perito- neum of the cul-de-sac. The increased diagnosis of endometriosis at laparoscopy can be explained by the increased experience and ability of the surgeon to detect such subtle lesions. The greatest change has been in the case of “subtle” lesions, which increased from 15% in 1986 to 65% in 1988. The diagnosis of peritoneal endometriosis at the time of laparoscopy is often made by the observation of typically puckered black or bluish lesions. There are, in addition, numerous subtle appearances of peritoneal endometriosis. These lesions, frequently nonpigmented, were diagnosed as endometriosis following confirmation by biopsy by Jansen and Russell in 1986. [less ▲]

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See detailCommon Prevalence Of Alanine And Glycine In Mobile Reactive Center Loops Of Serpins And Viral Fusion Peptides - Do Prions Possess A Fusion Peptide
Callebaut, I.; Tasso, A.; Brasseur, Robert ULg et al

in Journal of Computer-Aided Molecular Design (1994), 8(2),

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by ... [more ▼]

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by high levels of glycine. These two small residues, which are not simultaneously abundant in stable helices (standard or transmembrane), probably play an important role in mobility. Threonine and valine (also relatively small amino acids) are also abundant in these two kinds of peptides. Moreover, the known 3D structures of an uncleaved serpin reactive centre and a fusion peptide are strikingly similar. Such sequences possess many small residues and are found in several signal peptides and in PrP, a protein associated with spongiform encephalopathies and resembling virus envelope proteins. These properties may be related to the infection mechanisms of these diseases. [less ▲]

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See detailTechnical Study of Some Major Parameters Influencing the Performances of an Aerosol Delivery Equipment Suitable for Calves
Genicot, Bruno; Peckova, M.; Close, Roland et al

in Veterinary Research (1994), 25(5), 468-77

Aerosol delivery equipment, suitable for the treatment of bovine respiratory dysfunctions and including 2 parallelly positioned jet nebulizers, was studied in depth in order to determine the optimal ... [more ▼]

Aerosol delivery equipment, suitable for the treatment of bovine respiratory dysfunctions and including 2 parallelly positioned jet nebulizers, was studied in depth in order to determine the optimal working conditions in the field. Indeed, some factors might reasonably alter the performance of this equipment. Among these factors, the influences of the parallel position of jet nebulizers (in order to accommodate the breathing requirements of the cattle and achieve a rapid treatment), of the long feed pipe delivering compressed air (in order to keep the animal away from the compressor unit), and finally of the ambient temperature were studied, this equipment being essentially used during the winter season. This equipment could accommodate the breathing needs of cattle weighing up to 225 kg if a pressure of 600 kPa was developed upstream to the nebulizers. The rate of atomization was significantly reduced when working at ambient air temperatures (272.25 K < T < 274.65 K) close to those encountered in winter. This was especially true when pressure upstream to the nebulizers did not exceed 500 kPa. The immersion of the feed pipe for compressed air in hot water led to an increase in the rate of atomization without raising evaporative water losses, and reduced the drop in temperature in the nebulizer solution. Finally, the rate of atomization significantly increased when the face mask including the nebulizers was maintained so that the nebulizers were in a vertical position or at an angle not less than 60 degrees with respect to the ground. [less ▲]

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See detailIdentification Of Distinct Potyviruses In Mixedly-Infected Sweet-Potato By The Polymerase Chain-Reaction With Degenerate Primers
Colinet, D.; Kummert, J.; Lepoivre, Philippe ULg et al

in Phytopathology (1994), 84(1),

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See detailCharacterization of a single strong tissue-specific enhancer downstream from the three human genes encoding placental lactogen
Jacquemin, Patrick; Oury, Cécile ULg; Peers, Bernard ULg et al

in Molecular & Cellular Biology (1994), 14(1), 93-103

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3 ... [more ▼]

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3'. So far, a single placenta-specific enhancer has been identified in the locus, 2 kb downstream from the hCS-B gene, and shown to comprise one in vitro binding site for a nuclear protein. We here provide evidence that the hCS-B enhancer is more complex: (i) protection against DNase I digestion in the 3' flanking region of the hCS-B gene reveals four binding sites (DF-1, DF-2, DF-3, and DF-4) for nuclear proteins from either placental or HeLa cells, and (ii) placenta-specific enhancer activity can be fully exerted in transient expression experiments by a 126-bp fragment comprising the DF-3 and DF-4 protein-binding sites. By dissecting this region, we show that enhancer activity is mediated by a synergy between DF-3 and DF-4. Competitions with various oligonucleotides in footprinting and gel retardation experiments indicate that the same protein or set of proteins, different in HeLa and placenta cell nuclei, interacts with sites DF-2, DF-3, and DF-4. We also studied the regions of the hCS-L and hCS-A genes which are highly similar to the hCS-B enhancer. Although they each present the same four protein-binding sites, they exhibit only minor enhancer activity. [less ▲]

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See detailMachine learning, neural networks and statistical pattern recognition for voltage security: a comparative study
Wehenkel, Louis ULg; Van Cutsem, Thierry ULg; Pavella, Mania ULg et al

in International Journal of Intelligent Systems (1994), 2

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See detailSymbolic Verification with Periodic Sets
Boigelot, Bernard ULg; Wolper, Pierre ULg

in Lecture Notes in Computer Science (1994), 818

Symbolic approaches attack the state explosion problem by introducing implicit representations that allow the simultaneous manipulation of large sets of states. The most commonly used representation in ... [more ▼]

Symbolic approaches attack the state explosion problem by introducing implicit representations that allow the simultaneous manipulation of large sets of states. The most commonly used representation in this context is the Binary Decision Diagram (BDD). This paper takes the point of view that other structures than BDD's can be useful for representing sets of values, and that combining implicit and explicit representations can be fruitful. It introduces a representation of complex periodic sets of integer values, shows how this representation can be manipulated, and describes its application to the state-space exploration of protocols. Preliminary experimental results indicate that the method can dramatically reduce the resources required for state-space exploration. [less ▲]

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See detailOù peut-on planter l’aulne glutineux avec succès ?
Claessens, Hugues ULg

in Silva Belgica (1994), 101

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See detailInfluence de la pluie sur l'utilisation d'un abri par des taurillons au pâturage
Vandenheede, Marc ULg; Sheri, R.; Nicks, Baudouin ULg et al

in Annales de Médecine Vétérinaire (1994), 138

The time spent under a shelter by 8 grazing fattening bulls of the Belgian Blue breed was recorded during 35 days using a time-lapse recorder with IR illumination. The observation period was divided into ... [more ▼]

The time spent under a shelter by 8 grazing fattening bulls of the Belgian Blue breed was recorded during 35 days using a time-lapse recorder with IR illumination. The observation period was divided into 166 hours with rain (20 %) and 674 hours without precipitation (80 %). An occupation rate was calculated for each hour as the sum of the time spent under the shelter by each of the 8 bulls divided by 480 (8 animals x 60 minutes). The average occupation rates were 15.4 +/- 29.1 % for the hours with rain and 4.5 +/- 14.8 % for the hours without precipitation (P<0.001). The occupation rate was significantly influenced by intensity and duration of the rain : the occupation rate being higher during rainfall than with dry weather when the intensity of the rain was at least 0.4 l/m2 and the duration more than 2 hours. There was no significant difference between the live weight gain of the animals with a shelter and of other bulls grazing on an adjacent pasture without shelter. Our observations suggested however that a shelter may improve the welfare of the animals. [less ▲]

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See detailValeurs de référence de la ferritine sérique chez l'adulte
Vernet, M.; Revenant, M. C.; Charlier, Corinne ULg et al

in Annales de Biologie Clinique (1994), 52

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See detailTheoretical Conformational-Analysis And Synthesis Of Analogs Of The Heptapeptide Antibiotic K-582-A
Decoen, Jl.; Wathelet, Bernard ULg; Demeuse, F. et al

in International Journal of Peptide and Protein Research (1994), 43(1),

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See detailEtude du reservoir genetique de la legumineuse alimentaire Phaseolus lunatus L. par l'analyse electrophoretique d'isozymes.
Maquet, A.; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(3),

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See detailHIGH-RESOLUTION SPECTRA OF JUPITER NORTHERN AURORAL ULTRAVIOLET EMISSION WITH THE HUBBLE-SPACE-TELESCOPE
TRAFTON, L. M.; Gérard, Jean-Claude ULg; Munhoven, Guy ULg et al

in Astrophysical Journal (1994), 421(2), 816-827

The first spectroscopic observations of planetary aurora with the HST are reported. These include spectral regions centered on the H-2 Lyman and Werner bands of a region of Jupiter's northern aurora. The ... [more ▼]

The first spectroscopic observations of planetary aurora with the HST are reported. These include spectral regions centered on the H-2 Lyman and Werner bands of a region of Jupiter's northern aurora. The observations were made with the Goddard High Resolution Spectrograph (GHRS) using the Large Science Aperture as part of a campaign to study Jupiter at the time of the Ulysses flyby. The individual rotational-vibrational bands are resolved and the observed emissions are essentially all from H-2. A rotational-vibrational temperature for H-2 of 530 +/- 100 K is derived, a value significantly less than the 850-1100 K reported for Jovian H-3(+) in the near-infrared but consistent with the temperature reported for fundamental-band quadrupole H-2 emission. Comparison with the Faint Object Camera (FOC) images shows that the observed region was not one of the hot spots of the aurora. The results are interpreted in terms of electron impact excitation of H-2 from secondary particles generated by primaries precipitating into Jupiter's atmosphere from the magnetosphere. In the region of the aurora observed, the homopause level is found to be significantly hotter but not necessarily higher than observed at nonauroral latitudes. The equatorial H-2 dayglow spectrum was also detected; its intensity was 3.2 kR or 13% of the strength of the observed auroral emission. [less ▲]

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See detailImportance des insectes ravageurs des cereales stockees en Belgique.
Letellier, C.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Parasitica (1994), 50(1-2),

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See detailConstruction d'un modèle de répartition des arbres par classes de grosseur pour des plantations d'épicéa commun (Picea abies L Karst) en Ardenne belge
Lejeune, Philippe ULg

in Annales des Sciences Forestières (1994), 51(1), 53-65

The construction of a girth distribution model for Norway spruce (Picea abies L Karst) plantations has been considered using 141 sample plots of 1 000 m². The effects of the theoretical distribution ... [more ▼]

The construction of a girth distribution model for Norway spruce (Picea abies L Karst) plantations has been considered using 141 sample plots of 1 000 m². The effects of the theoretical distribution (comparison of the normal and Weibull distributions) and the estimation methods have been analysed. Despite the higher flexibility of the Weibull distribution, its use does not lead to a more accurate prediction of the distribution. The small number of samples measured in the plots seems to be the primary cause of the inaccuracy of the various models. Considering the data analysed, the normal distribution, which is easier to use, is proving to be more suitable for the creation of distribution model for such stands. [less ▲]

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See detailEvaluation of agents used in osteoporosis: What are the needs ?
Reginster, Jean-Yves ULg

in Osteoporosis Japan (1994), 2

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See detailMechanism of Thiamine Transport in Neuroblastoma Cells. Inhibition of a High Affinity Carrier by Sodium Channel Activators and Dependence of Thiamine Uptake on Membrane Potential and Intracellular Atp
Bettendorff, Lucien ULg; Wins, Pierre

in Journal of Biological Chemistry (1994), 269(20), 14379-14385

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a ... [more ▼]

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a saturable high affinity mechanism (Km = 35 nM). This was blocked by low concentrations of the Na+ channel activators veratridine (IC50 = 7 +/- 4 microM) and batrachotoxin (IC50 = 0.9 microM). These effects were not antagonized by tetrodotoxin and were also observed in cell lines devoid of Na+ channels, suggesting that these channels are not involved in the mechanism of inhibition. At high extracellular concentrations, thiamine uptake proceeds essentially via a low affinity carrier (Km = 0.8 mM), insensitive to veratridine but blocked by divalent cations. In both cases, the uptake was independent on external sodium, partially inhibited (10-35%) by depolarization and sensitive to metabolic inhibitors. A linear relationship between the rate of thiamine transport and intracellular ATP concentration was found. When cells grown in a medium of low thiamine concentration (6 nM) were exposed to 100 nM extracellular thiamine, a 3-fold increase in intracellular thiamine diphosphate was observed after 2 h while the concomitant increase in intracellular free thiamine was barely significant. These data suggest a secondary active transport of thiamine, the main driving force being thiamine phosphorylation rather than the sodium gradient. [less ▲]

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See detailQuantitative and qualitative study of the production of broad-spectrum antifungal lipopeptides from Bacillus subtilis S499.
Jacques, Ph.; Hbid, Ch.; Vanhentenryck, F. et al

in Progress in biotechnology (1994), 9

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See detailImmunological detection of beta-galactosidase-expressing cells by flow cytometry
Vanderplasschen, Alain ULg; Goltz, M.; Hanon, E.

in Biochemica (1994), 3

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See detailIdentification Of Functional-Sites On Bovine Leukemia-Virus Envelope Glycoproteins Using Structural And Immunological Data
Callebaut, I.; Portetelle, Daniel ULg; Burny, A. et al

in European Journal of Biochemistry (1994), 222(2),

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See detailA screening technique to isolate bacterial strains producing high molecular weight bacteriocins
Jabrane, A.; Destain, Jean-Pierre ULg; Compère, Philippe ULg et al

in Biotechnology Techniques (1994), 8(10), 751-754

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See detailThe Unbearable Burden of Being: Janet Frame's "Snowman, Snowman"
Delrez, Marc ULg

in Commonwealth : Essays and Studies (1994), 17(1), 89-99

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See detailTechnique for Ventricular Wrapping in Experimental Dynamic Cardiomyoplasty
Radermecker, Marc ULg; Bonnet, Pierre ULg; Philippart, C. et al

in Acta Chirurgica Belgica (1994), 94(5, Sep-Oct), 266-71

Cardiomyoplasty is a wrapping of an electrostimulated latissimus dorsi muscle flap around the heart for substitution and/or reinforcement. The surgical technique for reproducible cardiomyoplasties in the ... [more ▼]

Cardiomyoplasty is a wrapping of an electrostimulated latissimus dorsi muscle flap around the heart for substitution and/or reinforcement. The surgical technique for reproducible cardiomyoplasties in the goat model is presented. The methods combine the direction of wrapping (clockwise, counter-clockwise) and the orientation of muscle fibers. A cardiomyoplasty model using right and left latissimus dorsi or left latissimus dorsi and pectoralis major as well as a split muscle technique are illustrated. [less ▲]

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See detailSequencing And Analysis Of A 20.5-Kb Dna Segment Located On The Left Arm Of Yeast Chromosome-Xi
Vandenbol, Micheline ULg; Bolle, Pa.; Dion, C. et al

in Yeast (1994), 10

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See detail'Pattern' comportemental de type A : stress et maladie coronarienne : II. Aspects pratiques
Etienne, Anne-Marie ULg; Fontaine, Ovide ULg

in Revue Médicale de Liège (1994), XLIX(1), 36-48

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See detailSTRUCTURAL AND KINETIC CHARACTERIZATION OF A BETA-LACTAMASE-INHIBITOR PROTEIN
STRYNADKA, N. C. J.; JENSEN, S. E.; JOHNS, K. et al

in Nature (1994), 368(6472), 657-660

THE past decade has seen an alarming worldwide increase in resistance to beta-lactam antibiotics among many pathogenic bacteria1, which is due mainly to plasmid- or chromosomally encoded beta-lactamases ... [more ▼]

THE past decade has seen an alarming worldwide increase in resistance to beta-lactam antibiotics among many pathogenic bacteria1, which is due mainly to plasmid- or chromosomally encoded beta-lactamases that specifically cleave penicillin and cephalosporins, rendering them inactive. There is therefore a need to develop new strategies in the design of effective inhibitors of beta-lactamase. All the small-molecule inhibitors in clinical use are not very effective and are rapidly degraded2,3. Furthermore, newly characterized mutants of the plasmid-mediated beta-lactamase TEM-1 are highly resistant to these small-molecule inhibitors, including clavulanic acid and tazobactam4. It has been shown that Streptomyces clavuligerus produces an exocellular beta-lactamase inhibitory protein (BLIP; M(r) 17.5 K)5. Here we present data defining BLIP as the most effective known inhibitor of a variety of beta-lactamases, with K(i) values in the subnanomolar to picomolar range. To identify those features in BLIP that make it such a potent inhibitor, we have determined its molecular structure at 2.1 angstrom resolution. BLIP is a relatively flat molecule with a unique fold, comprising a tandem repeat of a 76-amino-acid domain. Each domain consists of a helix-loop-helix motif that packs against a four-stranded antiparallel beta-sheet (Fig. 1a). To our knowledge, BLIP is the first example of a protein inhibitor having two similarly folded domains that interact with and inhibit a single target enzyme. [less ▲]

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