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See detailEpidural anesthesia and intrathoracic blood volume.
Warner, David O; Brichant, Jean-François ULg; Ritman, Erik L et al

in Anesthesia and Analgesia (1993), 77(1), 135-40

To investigate how epidural anesthesia changes intrathoracic gas volume, high epidural anesthesia was administered to five pentobarbital-anesthetized dogs lying supine, and the total intrathoracic volume ... [more ▼]

To investigate how epidural anesthesia changes intrathoracic gas volume, high epidural anesthesia was administered to five pentobarbital-anesthetized dogs lying supine, and the total intrathoracic volume at end-expiration was measured with a high-speed three-dimensional x-ray scanner. The amount of gas in the lungs at end-expiration [the functional residual capacity (FRC)] was measured with a nitrogen washout technique, and the intrathoracic tissue volume, including the intrathoracic blood volume, was calculated as the difference between intrathoracic volume at end-expiration and FRC. High epidural anesthesia with the local anesthetic etidocaine to a T-1 myotomal level significantly (P < 0.05) increased intrathoracic volume at end-expiration [76 +/- 35 mL (M +/- SD)] by significantly increasing both intrathoracic tissue volume (33 +/- 15 mL) and FRC (43 +/- 26 mL). Increases in intrathoracic tissue volume were probably caused by increases in intrathoracic blood volume. We conclude that increases in FRC caused by epidural anesthesia in anesthetized dogs lying supine may be minimized by a concurrent increase in intrathoracic blood volume. These results suggest that measurements of thoracic gas volume alone may be insufficient to describe chest wall responses to epidural anesthesia. [less ▲]

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See detailEvolutionary relationships among higher fungi inferred from small ribosomal subunit RNA sequence analysis
Wilmotte, Annick ULg; Van De Peer, Yves; Goris, Anne et al

in Systematic & Applied Microbiology (1993), 16

The primary structure of the small ribosomal subunit RNA (SSU rRNA) was determined for 13 species belonging to 10 ascomycete families and for the basidiomycetous anamorphic yeast Rhodotorula glutinis. The ... [more ▼]

The primary structure of the small ribosomal subunit RNA (SSU rRNA) was determined for 13 species belonging to 10 ascomycete families and for the basidiomycetous anamorphic yeast Rhodotorula glutinis. The sequences were fitted into an alignment of all hitherto published complete or nearly complete eukaryotic small subunit rRNA sequences. The evolutionary relationships within the fungi were examined by construction of a tree from 87 SSU rRNA sequences, corresponding to 71 different species, by means of a distance matrix method and bootstrap analysis. It confirms the early divergence of the zygomycetes and the classical division of the higher fungi into basidiomycetes and ascomycetes. The basidiomycetes are divided into true basidiomycetes and ustomycetes. Within the ascomycetes, the major subdivisions hemiascomycetes and euascomycetes can be recognized. However, Schizosaccharomyces pombe does not belong to the cluster of the hemiascomycetes, to which it is assigned in classical taxonomic schemes, but forms a distinct lineage. Among the euascomycetes, the plectomycetes and the pyrenomycetes can be distinguished. Within the hemiascomycetes, the polyphyly of genera like Pichia or Candida and of families like the Dipodascaceae and the Saccharomycetaceae can be observed. [less ▲]

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See detailReplacing the (beta alpha)-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme
Mainfroid, Véronique; Goraj, Karine; Rentier-Delrue, Françoise ULg et al

in Protein Engineering (1993), 6(8), 893-900

In order to investigate how structural modifications interfere with protein stability, we modified a (beta alpha)-unit in E.coli triosephosphate isomerase (TIM), a typical (beta alpha)-barrel protein ... [more ▼]

In order to investigate how structural modifications interfere with protein stability, we modified a (beta alpha)-unit in E.coli triosephosphate isomerase (TIM), a typical (beta alpha)-barrel protein, assuming that the pseudosymmetrical beta-barrel can be divided into eight successive loop/beta-strand/loop/alpha-helix motifs. We replaced the eighth (beta alpha)-unit of E.coli TIM with the corresponding chicken (beta alpha)-unit. The substitution, involving the replacement of 10 of the 23 residues of this (beta alpha)-unit, was evaluated first by modelling, then experimentally. Modelling by homology suggests how the amino acid replacements might be accommodated in the hybrid E.coli/chicken TIM (ETIM8CHI). Both natural and hybrid recombinant TIMs, overproduced in E.coli, were purified to homogeneity and characterized as to their stability and kinetics. Our kinetic studies show that the modification performed here leads to an active enzyme. The stability studies indicate that the stability of ETIM8CHI is comparable to that of the wild type TIM. [less ▲]

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See detailA VARIABLE MECHANISM FOR THE NUCLEOPHILIC VINYLIC SUBSTITUTIONS IN A SERIES OF GEM-DIHALOGENATED ALKENES BY A BIDENTATE SULFUR NUCLEOPHILE - AN EXPERIMENTAL AND AM1 THEORETICAL-STUDY
Gimbert, Yves; Moradpour, Alec; Dive, Georges ULg et al

in Journal of Organic Chemistry (1993), 58(17), 4685-4690

The nucleophilic substitutions of a series of gem-dihalogenated alkenes 3,5,7,8, and 9 (RS)2C=CX2 (X = Cl, F) with 1,2-benzenedithiolate b have been studied. Depending on the structures of the R groups ... [more ▼]

The nucleophilic substitutions of a series of gem-dihalogenated alkenes 3,5,7,8, and 9 (RS)2C=CX2 (X = Cl, F) with 1,2-benzenedithiolate b have been studied. Depending on the structures of the R groups (alkyl, saturated and unsaturated cycloalkyls, aromatic ring), the course of the reactions and the structures of the yielded products are modified. In the frame of the addition-elimination-type mechanism for these nucleophilic substitutions, the energy contents of the anionic intermediates, resulting from the additions of the nucleophile b to the unsaturated centers, is calculated at the AM1 method level. For the compounds 5, 7, 8, and 9, the calculated energies nicely corroborate the experimental results. For 3, anionic intermediates are no longer found by calculation, and a synchronous single-step substitution is strongly suggested. [less ▲]

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See detailOrganization of partner preference and sexual behavior and its nocturnal rhythmicity in male rats.
Bakker, Julie ULg; van Ophemert, J.; Slob, A. K.

in Behavioral Neuroscience (1993), 107(6), 1049-58

Male rats were neonatally treated with 1,4,6-androstatriene-3,17-dione (ATD), which blocks aromatization of testosterone (T) to estradiol (E2), from Days 0, 2, or 5 through 14. Adult partner preference ... [more ▼]

Male rats were neonatally treated with 1,4,6-androstatriene-3,17-dione (ATD), which blocks aromatization of testosterone (T) to estradiol (E2), from Days 0, 2, or 5 through 14. Adult partner preference behavior (PPB; choice between estrous female rat [F] and active male rat [M]) was studied in the early part of the dark phase of the light-dark (LD) cycle. ATD Day 0 Ms showed a preference for the stimulus M or showed no preference for either of the stimulus Ss. Controls preferred the estrous F. ATD Days 2 and 5 Ms showed PPB intermediate between ATD Day 0 Ms and controls. Thus the neonatally sensitive period for organization of adult PPB extends beyond Day 5. Furthermore, PPB showed a nocturnal rhythmicity in ATD Ms but not in controls. In the late part of the dark phase, all Ms showed a preference for the stimulus F. ATD Days 2 and 5 Ms and control Ms were no longer different in PPB, but ATD Day 0 Ms still showed significantly lower preference scores for F than all other Ms. Thus the E2 metabolite of T suppresses organization of an adult nocturnal rhythm in PPB. [less ▲]

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See detailThe evolution of atmospheric extinction at La Silla derived from measurements in the Stromgren photometric system
Sterken, C.; Manfroid, Jean ULg

in Astronomy and Astrophysics (1992), 266

We describe atmospheric extinction data obtained at the La Silla Observatory in the Stromgren photometric system. Our measurements, covering a time interval of almost fifteen years, show three episodes of ... [more ▼]

We describe atmospheric extinction data obtained at the La Silla Observatory in the Stromgren photometric system. Our measurements, covering a time interval of almost fifteen years, show three episodes of increased extinction due to airborne aerosols of volcanic origin. A small-amplitude seasonal variation and a short-timescale pseudo-periodic oscillation are also revealed. Implications on the observing procedures and photometric reduction schemes are discussed. [less ▲]

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See detailLong-term stability of classical photometry
Hensberge, H.; Manfroid, Jean ULg; Sterken, C.

in The Messenger (1992), 70

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See detailStandard stars for the Infrared Space Observatory, ISO.
van der Bliek, N. S.; Bouchet, P.; Habing, H. J. et al

in The Messenger (1992), 70

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See detailField Efficacy of Injectable and Pour-on Moxidectin in Cattle Naturally Infested with Psoroptes Ovis (Acarina: Psoroptidae)
Lonneux, J. F.; Losson, Bertrand ULg

in Veterinary Parasitology (1992), 45(1-2), 147-52

Field efficacy of moxidectin, a macrocyclic lactone endectocide, was evaluated in cattle naturally infested with Psoroptes ovis. Three groups of six animals were used based on parasitological and clinical ... [more ▼]

Field efficacy of moxidectin, a macrocyclic lactone endectocide, was evaluated in cattle naturally infested with Psoroptes ovis. Three groups of six animals were used based on parasitological and clinical status. Group 1 animals received one subcutaneous injection of injectable moxidectin at 0.2 mg kg-1 body weight; Group 2 animals received topically one dose of 0.5 mg kg-1 body weight of pour-on moxidectin; Group 3 individuals remained untreated as controls. Efficacy was assessed by (a) taking skin samples from each animal on Days -4, 14, 28, 42 and 56 post-treatment (PT) and observing numbers of viable mite stages and species and (b) clinical examination of animals on Days 14, 28, 42 and 56 with the percentage of affected body surface calculated for each animal on Days -4, 28 and 56. Both formulations gave 100% efficacy as no live mites were found in Groups 1 or 2, 14, 28 and 56 days after treatment. Clinical indices showed a sharp decrease in the affected body surface area from a mean of 5.48% and 6.1% on Day -4 in Groups 1 and 2, respectively, to 0% in both groups on Days 28 and 56 PT. All untreated animals remained positive until Day 28. The clinical condition of the controls worsened rapidly during the experiment (mean clinical index: 2.87% and 13.05% on Days -4 and 28, respectively) and they were given an emergency treatment on Day 28. No side-effects were observed with either formulation.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailOxytocin blocks the environmentally conditioned compensatory response present after tolerance to ethanol-induced hypothermia in mice
Tirelli, Ezio ULg; Jodogne, C.; Legros, Jean-Jacques ULg

in Pharmacology, Biochemistry & Behavior (1992), 43(4), 1263-1267

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment ... [more ▼]

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment-specific tolerance. According to the conditioning model of tolerance, such tolerance occurs because an opposite compensatory response conditioned to ethanol-paired cues attenuates ethanol's effects. Tolerance to ethanol-induced hypothermia was established to a particular environment over 4 days by injecting mice (daily) with oxytocin 2 h before ethanol, outside the colony room. As controls, other mice were injected similarly but following testing in the animal room. We found that oxytocin suppressed the conditioned compensatory response, revealed by injecting saline to every group in the tolerance-associated environment. These results suggest that oxytocin acted, at least partly, via an inhibition of the associative learning processes that facilitate tolerance development. [less ▲]

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See detailLe portage asymptomatique des Pestivirus chez les ruminants
Pastoret, Paul-Pierre ULg; Boulanger, D.; Mignon, Bernard ULg et al

in Revue Scientifique et Technique (International Office of Epizootics) (1992), 11(4), 1087-1096

Pestiviruses are enveloped single-chain ribonucleic acid viruses with a positive polarity. Pestiviruses include the viruses of classical swine fever (hog cholera), Border disease of sheep, mucosal disease ... [more ▼]

Pestiviruses are enveloped single-chain ribonucleic acid viruses with a positive polarity. Pestiviruses include the viruses of classical swine fever (hog cholera), Border disease of sheep, mucosal disease of cattle, and isolates obtained from wild animals, such as red deer (Cervus elaphus). Among ruminants, pestiviruses have developed a remarkable strategy for assuring their persistence. Through epigenetic transmission, they lead to the birth of asymptomatic carrier animals harbouring non-cytopathic variants, which become immunotolerant to the strain of virus present. The presence of a small number of asymptomatic carriers enables the virus to circulate within a herd by horizontal transmission, leading to the birth of a new generation of asymptomatic carriers. [less ▲]

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See detailModel-Based System for Automatic Target Recog- nition from Forward-Looking Laser-Radar Imagery
Verly, Jacques ULg; Delanoy, Richard L.; Dudgeon, Dan E.

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (1992), 31(12), 2540-2552

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See detailQuantification of skin color in patients undergoing maintenance hemodialysis
Deleixhe-Mauhin, F.; Krzesinski, Jean-Marie ULg; Rorive, Georges ULg et al

in Journal of the American Academy of Dermatology (1992), 27(6), 950-953

Background: In patients undergoing long-term hemodialysis, a peculiar hyperpigmentation develops, the intensity of which may or may not be related to the duration of treatment and use of erythropoietin ... [more ▼]

Background: In patients undergoing long-term hemodialysis, a peculiar hyperpigmentation develops, the intensity of which may or may not be related to the duration of treatment and use of erythropoietin. Objective: Our purpose was to conduct a comparative cross-sectional study of white patients with distinct diseases that modify their skin color. Methods: A reflected-light colorimeter was used to compare the color of the forehead and forearms of 61 white patients receiving hemodialysis with that of matched controls and of patients with anemia or icterus. Results: Significant differences were found in both reflectance and chromaticity between these groups of patients. Duration of hemodialysis and use of erythropoietin did not significantly influence the colorimetric measurements. Conclusion: The use of a color-reflectance meter allows precise evaluation of subtle changes in skin color and may be used to monitor several diseases. [less ▲]

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See detailUtilisation d'un S.I.G. pour la gestion des ressources forestières : exemple d'application à un inventaire forestier régional
Lejeune, Philippe ULg; Lecomte, Hugues; Prevot, Hugues ULg

in Bulletin des Recherches Agronomiques de Gembloux (1992), 28(2-3), 275-286

Le développement des Systèmes d'Information Géographiques (S.I.G.) ouvre de nouvelles perspectives dans le domaine de l'estimation des ressources forestières par voie d'inventaires, dont l'objectif ... [more ▼]

Le développement des Systèmes d'Information Géographiques (S.I.G.) ouvre de nouvelles perspectives dans le domaine de l'estimation des ressources forestières par voie d'inventaires, dont l'objectif principal est de déterminer les surfaces et les volumes sur pied par types de peuplement au sein d'une région donnée. La technique d'estimation des surfaces par comptage de points, classiquement utilisée dans le cas d'échantillonages systématiques, peut être avantageusement remplacée par la création, au sein d'un S.I.G., d'une carte numérique des peuplements forestiers, pouvant être reliée avec les données de l'inventaire au sol. Une méthodologie est proposée pour produire une telle carte au départ de photos aériennes infrarouges couleurs au 1/25 000. Le traitement de l'information géographique est réalisé à l'aide du logiciel ILWIS. La méthode a été testée sur une zone pilote de 20 000 ha de forêt. Le taux d'erreurs d'interprétation du type de peuplement est de l'ordre de 15 %. Il est inférieur à 6 % si l'on ne considère que les confusions portant sur les essences présentes. La combinaison de cette carte avec la couche contenant les placettes de l'inventaire a permis d'estimer l'ensemble des volumes sur pied par types de peuplement. [less ▲]

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See detailTwo Different Beta-Lactamase Genes Are Present in Streptomyces Cacaoi
Magdalena, Juana; Forsman, Mats; Lenzini, Mauro V et al

in FEMS Microbiology Letters (1992), 78(1), 101-5

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See detailSecretion by Overexpression and Purification of the Water-Soluble Streptomyces K15 Dd-Transpeptidase/Penicillin-Binding Protein
Palomeque-Messia, Pilar; Quittre, Valérie; Leyh-Bouille, Mélina et al

in Biochemical Journal (1992), 288(1), 87-91

Though synthesized with a cleavable signal peptide and devoid of membrane anchors, the 262-amino-acid-residue Streptomyces K15 DD-transpeptidase/penicillin-binding protein is membrane-bound ... [more ▼]

Though synthesized with a cleavable signal peptide and devoid of membrane anchors, the 262-amino-acid-residue Streptomyces K15 DD-transpeptidase/penicillin-binding protein is membrane-bound. Overexpression in Streptomyces lividans resulted in the export of an appreciable amount of the synthesized protein (4 mg/litre of culture supernatant). The water-soluble enzyme was purified close to protein homogeneity with a yield of 75%. It requires the presence of 0.5 M-NaCl to remain soluble. It is indistinguishable from the detergent-extract wild-type enzyme with respect to molecular mass, thermostability, transpeptidase activity and penicillin-binding capacity. [less ▲]

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See detailMacromolecular engineering of polylactones and polylactides. 8. Ring-opening polymerization of ε-caprolactone initiated by primary amines and trialkylaluminum
Dubois, Philippe; Degée, Philippe; Jérôme, Robert ULg et al

in Macromolecules (1992), 25

Whenever added with triethylaluminum, primary amines have been found to be effective initiators for epsilon-caprolactone polymerization in both toluene and THF at 40°C. The IR and NMR analysis of the ... [more ▼]

Whenever added with triethylaluminum, primary amines have been found to be effective initiators for epsilon-caprolactone polymerization in both toluene and THF at 40°C. The IR and NMR analysis of the polyester has supported a polymerization mechanism proceeding through a "coordination-insertion" pathway and the selective rupture of the acyl-oxygen bond of the monomer. The alkylaluminum activates the carbonyl group of the monomer and accordingly favors the nucleophilic addition of the amine, which is the actual initiation step. Propagation is typically a living process, and the molecular weight distribution is controlled by both AlEt3/amine molar ratio and solvent As an extension of that mechanism, diethylaluminum omega-amino alkoxide has been prepared on purpose and successfully used as an initiator for the synthesis of α,ω-dihydroxypoly(ε-caprolactone). [less ▲]

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See detailQualitative analysis of ten-dimensional lovelock cosmological models
Demaret, Jacques; De Rop, Yves ULg; Tombal, P. et al

in General Relativity & Gravitation (1992), 24

The Einstein-like field equations obtained from the variation of a Lagrangian containing linear, quadratic (Gauss-Bonnet) and quartic terms for a ten-dimensional cosmological model cannot be solved ... [more ▼]

The Einstein-like field equations obtained from the variation of a Lagrangian containing linear, quadratic (Gauss-Bonnet) and quartic terms for a ten-dimensional cosmological model cannot be solved analytically. However, we can reduce them to a system of dynamical equations for the “Hubble parameters”. The study of the mathematical properties of the fixed points of this system gives a qualitative picture of the behaviour of a class of possible solutions. The inclusion of a quartic term generates an extremely rich structure for the corresponding dynamical system. Some solutions are shown to exhibit the interesting property of dimensional reduction, which has been proposed as a possible explanation of the three-dimensional character of our universe. [less ▲]

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See detailNeuroendocrine Mechanism of Onset of Puberty. Sequential Reduction in Activity of Inhibitory and Facilitatory N-Methyl-D-Aspartate Receptors
Bourguignon, Jean-Pierre ULg; Gerard, Arlette ULg; Alvarez Gonzalez, Maria-Luz ULg et al

in Journal of Clinical Investigation (1992), 90(5), 1736-44

In humans and in several animal species, puberty results from changes in pulsatile gonadotropin-releasing hormone (GnRH) secretion in the hypothalamus. In particular, the frequency of pulsatile GnRH ... [more ▼]

In humans and in several animal species, puberty results from changes in pulsatile gonadotropin-releasing hormone (GnRH) secretion in the hypothalamus. In particular, the frequency of pulsatile GnRH secretion increases at the onset of puberty, as can be shown by using hypothalamic explants of male rats of 15 and 25 d. Previous observations from us and others suggested that the initiation of puberty could involve a facilitatory effect of excitatory amino acids mediated through N-methyl-D-aspartate (NMDA) receptors. We found that GnRH secretion could be activated through NMDA receptors only around the time of onset of puberty (25 d). The aim of this study was to clarify why this activation did not occur earlier (at 15 d) and could no longer be observed by the end of puberty (at 50 d). We studied GnRH secretion in the presence of MK-801, a noncompetitive antagonist of NMDA receptors or AP-5, a competitive antagonist. We showed that, in the hypothalamus of immature male rats (15 d), a highly potent inhibitory control of pulsatile GnRH secretion in vitro was mediated through NMDA receptors. These data were confirmed in vivo because administration of the antagonist MK-801 (0.001 mg/kg) to immature male rats resulted in early pubertal development. Onset of puberty (25 d) was characterized by the disappearance of that NMDA receptor-mediated inhibition, thus unmasking a facilitatory effect also mediated through NMDA receptors. During puberty, there was a reduction in activity of this facilitatory control which was no longer opposed by its inhibitory counterpart. We conclude that a sequential reduction in activity of inhibitory and facilitatory NMDA receptors provides a developmental basis for the neuroendocrine mechanism of onset of puberty. [less ▲]

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See detailIn Vitro and in Vivo Modulation of 5-Hydroxytryptamine-, Thyrotropin-Releasing Hormone- and Calcitonin-Gene Related Peptide-Like Immunoreactivities in Adult Rat Sensory Neurons
Delree, P.; Martin, Didier ULg; Sadzot-Delvaux, Catherine ULg et al

in Neuroscience (1992), 51(2), 401-10

In a previous work we have shown that culturing adult rat dorsal root ganglia neurons modifies their neurotransmitter phenotype in such a way that cultured neurons synthesize transmitters that are not ... [more ▼]

In a previous work we have shown that culturing adult rat dorsal root ganglia neurons modifies their neurotransmitter phenotype in such a way that cultured neurons synthesize transmitters that are not found in situ, while several other transmitters are expressed in a much higher percentage of neurons in culture than in situ [Schoenen J. et al. (1989) J. Neurosci. Res. 22, 473-487]. The aim of the present study was to investigate the origin and the nature of the relevant environmental signals that allow this plasticity to be expressed, focusing on three neurotransmitters: 5-hydroxytryptamine, thyrotropin-releasing hormone and calcitonin-gene related peptide. The main results can be summarized as follows: (1) culturing cells in fetal calf serum or on feeder layers of astrocytes, Schwann cells or fibroblasts partially inhibits the serotoninergic phenotype of dorsal root ganglia neurons; (2) in vivo disconnection of dorsal root ganglia from their spinal targets but not from their peripheral or supraspinal targets induces a significant increase of the percentage of 5-hydroxytryptamine- and thyrotropin-releasing hormone-positive neurons in disconnected ganglia; (3) growth factors such as ciliary neuronotrophic factor or basic fibroblast growth factor but not nerve growth factor repress 5-hydroxytryptamine and calcitonin gene-related peptide immunoreactivity in cultured sensory neurons. In conclusion, neurotransmitter gene expression of adult dorsal root ganglia neurons is controlled by complex influences. Our data suggest that thyrotropin-releasing hormone and 5-hydroxytryptamine gene expression are tonically repressed in vivo by factors originating from the spinal segmental level and that growth factors such as ciliary neurotrophic factor or basic fibroblast growth factor could be potential vectors of this repressing effect. [less ▲]

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See detailA Molecular Biologic Study of Extracellular Matrix Components During the Development of Glomerulosclerosis in Murine Chronic Graft-Versus-Host Disease
Munaut, Carine ULg; Bergijk, E. C.; Baelde, J. J. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1992), 67(5), 580-7

BACKGROUND: We studied the development of glomerulosclerosis in murine chronic graft-versus-host disease, a model for human systemic lupus erythematosus. EXPERIMENTAL DESIGN: The disease was induced in ... [more ▼]

BACKGROUND: We studied the development of glomerulosclerosis in murine chronic graft-versus-host disease, a model for human systemic lupus erythematosus. EXPERIMENTAL DESIGN: The disease was induced in (C57BL10 x DBA/2)F1 hybrids by injection of DBA/2 lymphocytes leading to deposition of auto-antibodies in the glomeruli, and a lupus type of nephritis morphologically. We have determined the levels of mRNA coding for laminin (B1 and B2), a 67 kilodalton laminin binding protein, and types I and IV collagen, in control and graft-versus host disease mice at various times after disease induction. RESULTS: Laminin and collagen mRNAs were increased in whole kidneys 4 weeks after induction of the disease. At week 10, all animals displayed dramatic stimulation of alpha 1(I), alpha 1(IV), laminin B1, and B2 mRNAs. The 67 kilodalton laminin binding protein mRNA was also doubled from week 4 to 16. In isolated glomeruli, the mRNA level coding for laminin B2 was already significantly increased from week 8. This enhancement of laminin synthesis corresponds to the mesangial expansion and to the development of laminin-containing spike formations of the glomerular basement membrane at week 8. CONCLUSIONS: The expansion of the mesangial matrix in murine chronic graft-versus-host disease is caused at least in part, by an increased production of extracellular matrix components by glomerular cells. These results demonstrate that the increase of specific extracellular matrix components mRNAs precedes light microscopic changes. Quantitative evaluation of the mRNA levels coding for extracellular matrix proteins may reveal a useful method for the early detection of the development of glomerular sclerosis at the stage preceding the onset of anatomo-clinical changes. [less ▲]

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See detailMinimal Levels of Serum Estradiol Prevent Postmenopausal Bone Loss
Reginster, Jean-Yves ULg; Sarlet, Nathalie ULg; Deroisy, Rita ULg et al

in Calcified Tissue International (1992), 51

Biochemical parameters reflecting bone resorption [urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OH/Cr)] were related to serum estrogens [estrone (E1) and estradiol (E2)] in 262 ... [more ▼]

Biochemical parameters reflecting bone resorption [urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OH/Cr)] were related to serum estrogens [estrone (E1) and estradiol (E2)] in 262 healthy women including 158 patients receiving estrogen replacement therapy (ERT) for at least 6 months, 49 eugonadal women, and 55 untreated postmenopausal women. A significant (P < 0.001) correlation exists between serum E2 and Ca/Cr: Ca/Cr (mg/dl) = -0.00044 E2 (pg/ml) + 0.129 (n = 262; r = -0.37), serum E2 and OH/Cr: (OH/Cr (mg/g) = -0.049 E2 (pg/ml) + 18.76 (n = 262; r = -0.36), serum E1 and Ca/Cr: Ca/Cr (mg/dl) = -0.0003 E1 (pg/ml) + 0.127 (n = 261; r = -0.28) but not between serum E1 and OH/Cr. Women with circulating levels of E2 between 60 and 90 pg/ml have a significant (P < 0.01) reduction of Ca/Cr and OH/Cr when compared with those with lower levels of E2. Higher values of E2 do not provide additional benefit. We conclude that in postmenopausal women receiving an estrogen replacement therapy (ERT), a significant reduction of bone resorption is achieved when circulating levels of estradiol reach a value (60 pg/ml) corresponding to the one measured, in eugonadal women, during the last days of the early follicular phase of the menstrual cycle. We suggest that oral or percutaneous ERT should induce a minimal value of 60 pg/ml to prevent postmenopausal bone loss. [less ▲]

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See detailMolecular Biology of Bovine Herpesvirus Type 4
Thiry, Etienne ULg; Bublot, M.; Dubuisson, J. et al

in Veterinary Microbiology (1992), 33(1-4), 79-92

Bovine herpesvirus type 4 (BHV-4) is a ubiquitous virus of cattle. Its genome is a 144 +/- 6 kb double-stranded DNA consisting of a unique central part (L-DNA) flanked at both ends by tandem repeats ... [more ▼]

Bovine herpesvirus type 4 (BHV-4) is a ubiquitous virus of cattle. Its genome is a 144 +/- 6 kb double-stranded DNA consisting of a unique central part (L-DNA) flanked at both ends by tandem repeats called polyrepetitive DNA (prDNA or H-DNA). The overall arrangement of genes has been obtained by the analysis of homologies between short BHV-4 DNA sequences and corresponding genes of Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS). The gene expression is temporally regulated. Glycoprotein precursor p (gp10/gp17) is expressed as gamma 1 polypeptide. Glycoproteins gp1, gp8, gp11 and their precursors are gamma 2 proteins. The analysis of strain variations allows the definition of two types of strains, based on the DNA patterns: the Movar 33/63-like and the DN 599-like strains. Only the M40 strain, isolated in India, fails to fit this classification. The genomic variations have been compiled to build a dendrogram showing three levels of divergence between BHV-4 strains or isolates. The available molecular data indicate that the BHV-4 genome shares much similarity with the DNA of EBV and HVS, two representative members of the gammaherpesvirinae. BHV-4 may therefore be classified in the subfamily gammaherpesvirinae. [less ▲]

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See detailAdaptation du système cardio-respiratoire de la personne âgée soumise à l'entrainement physique
Hoffer, E.; Pierard, Luc ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1992), 47(11), 560-72

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See detailLes syndromes hémorragiques pulmonaires diffus: approches clinique et diagnostique
Bury, Thierry ULg; Corhay, Jean-Louis ULg; Kotolenko, S. et al

in Revue Médicale de Liège (1992), 47(11), 554-9

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See detailElectro-optic coefficient measurements : correction of electric-field inhomogeneities in the transverse configuration
Lemaire, Philippe; Georges, Marc ULg

in Optics Letters (1992), 17(20), 1411-1413

The problem of electric-field inhomogeneities in the measurement of the electro-optic coefficient in the transverse configuration is well known. We present a simple way to solve these difficulties. It ... [more ▼]

The problem of electric-field inhomogeneities in the measurement of the electro-optic coefficient in the transverse configuration is well known. We present a simple way to solve these difficulties. It involves local measurements at several points along the transverse direction of the phase difference between two components of light traveling through the crystal. The electro-optic coefficient is simply calculated by integrating the phase shifts along the transverse profile. For this procedure one needs nothing but the value of the voltage applied to the crystal, and knowledge of the internal electric field is not necessary. Limits of application are discussed, and results are shown for photorefractive sillenite crystals. [less ▲]

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See detailTumor Cell Surface-Associated Binding Site for the M(R) 72,000 Type Iv Collagenase
Emonard, H. P.; Remacle, A. G.; Noël, Agnès ULg et al

in Cancer Research (1992), 52(20), 5845-8

We have studied the capacity of two human breast adenocarcinoma cells, MDA-MB231 and MCF-7, to bind exogenous M(r) 72,000 type IV collagenase by both morphological and radioreceptor binding assays. By ... [more ▼]

We have studied the capacity of two human breast adenocarcinoma cells, MDA-MB231 and MCF-7, to bind exogenous M(r) 72,000 type IV collagenase by both morphological and radioreceptor binding assays. By indirect immunofluorescence, staining with a specific anti-M(r) 72,000 type IV collagenase antibody was strongly induced when cells were preincubated with the purified enzyme. Scatchard plot analysis indicated the existence of a binding site for the M(r) 72,000 type IV collagenase with high affinity for both cell lines (Kd = 2 x 10(-9) M). These results are the first demonstration of the existence of a tumor cell membrane-associated putative receptor for a member of the matrix metalloproteinase family, as previously evidenced for the urokinase-type plasminogen activator. [less ▲]

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See detailAnionic polymerization of acrylic monomers. 8. Synthesis and characterization of (meth)acrylic end-functionalized polymers: macromonomers and telechelics
Varshney, Sunil K; Bayard, Philippe; Jacobs, Christian et al

in Macromolecules (1992), 25(21), 5578-5584

Tailor-made poly(tert-butyl acrylate) macromonomers, which are useful building blocks for the synthesis of comb or multiblock copolymers, have been successfully synthesized by deactivation of living PtBA ... [more ▼]

Tailor-made poly(tert-butyl acrylate) macromonomers, which are useful building blocks for the synthesis of comb or multiblock copolymers, have been successfully synthesized by deactivation of living PtBA macroanions with suitable electrophiles bearing either styrene or methacrylic unsaturation. Mono- or bifunctional initiators such as sec-butyllithium or naphthalenyllithium can be used. When these initiators were modified by LiCl as a mu-type ligand, the macroanions which are known to be living were functionalized with high efficiency. Characterization of the various macromonomers was performed using H-1 NMR spectroscopy and SEC. [less ▲]

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See detailThe thermospheric odd nitrogen photochemistry - Role of non thermal N(4S) atoms
Shematovich, V. I.; Bisikalo, D. V.; Gérard, Jean-Claude ULg

in Annales Geophysicae [= ANGEO] (1992), 10

A nonequilibrium model to calculate the Maxwellian 'hot' N(4S) atom population using a Monte Carlo method is developed, and the NO vertical distribution for minimum solar cycle conditions is calculated ... [more ▼]

A nonequilibrium model to calculate the Maxwellian 'hot' N(4S) atom population using a Monte Carlo method is developed, and the NO vertical distribution for minimum solar cycle conditions is calculated. It is shown that the energetic photoelectrons produced by solar soft X-rays produce translationally 'hot' N(4S) atoms near 110 km which contribute significantly to the formation of the E-region NO peak observed at this altitude. Consideration of this new source of nitric oxide reconciles the need for an effective N(2D) quantum yield from N2 dissociation exceeding 50 percent derived from odd nitrogen models with the limits put on this value by laboratory and theoretical constraints. The altitude of the modeled NO peak is found to critically depend on the adopted N(2D) yield, and good agreement with the observed peak altitude and density is obtained using the quantum yield derived from theoretical considerations. [less ▲]

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See detailStructure, function, and fate of the BlaR signal transducer involved in induction of β-lactamase in Bacillus licheniformis
Zhu, Yingfang; Englebert, Serge; Joris, Bernard ULg et al

in Journal of Bacteriology (1992), 174(19), 6171-6178

The membrane-spanning protein BlaR is essential for the induction of beta-lactamase in Bacillus licheniformis. Its nature and location were confirmed by the use of an antiserum specific for its carboxy ... [more ▼]

The membrane-spanning protein BlaR is essential for the induction of beta-lactamase in Bacillus licheniformis. Its nature and location were confirmed by the use of an antiserum specific for its carboxy-terminal penicillin sensor, its function was studied by genetic dissection, and the structure of the penicillin sensor was derived from hydrophobic cluster analysis of the amino acid sequence by using, as a reference, the class A beta-lactamases with known three-dimensional structures. During the first 2 h after the addition of the beta-lactam inducer, full-size BlaR, bound to the plasma membrane, is produced, and then beta-lactamase is produced. By 2 h after induction, BlaR is present in various (membrane-bound and cytosolic) forms, and there is a gradual decrease in beta-lactamase production. The penicillin sensors of BlaR and the class D beta-lactamases show strong similarities in primary structures. They appear to have the same basic spatial disposition of secondary structures as that of the class A beta-lactamases, except that they lack several alpha helices and, therefore, have a partially uncovered five-stranded beta sheet and a more readily accessible active site. Alterations of BlaR affecting conserved secondary structures of the penicillin sensor and specific sites of the transducer annihilate beta-lactamase inducibility. [less ▲]

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See detailThe Beta Pictoris circumstellar disk. XIII - Survey of the variable CA II lines
Lagrange-Henri, A. M.; Gosset, Eric ULg; Beust, H. et al

in Astronomy and Astrophysics (1992), 264

Over 200 Ca II K and H spectra of Beta Pictoris taken between September 19, 1989 and December 19, 1990 are presented. Many new variable features are observed, at low and high redshifts, together with a ... [more ▼]

Over 200 Ca II K and H spectra of Beta Pictoris taken between September 19, 1989 and December 19, 1990 are presented. Many new variable features are observed, at low and high redshifts, together with a few blueshifted ones. The time scales for the variations are shown to be strongly dependent on the redshift of the variable lines. A rate of events of about 200/yr is derived; it is also shown that in some cases the absorbing cloud covers less than 40 percent of the stellar surface. The observed variations are analyzed and compared to those observed in the UV. These observations make it possible to test the present scenario of evaporating infalling bodies, in terms of velocity of variable lines, occurrence of variable events, small time-scale variations, and size of the absorbing cloud. It is shown that the observed velocity range for the variable components may be explained by the present scenario, as well as the size of the absorbing clouds. [less ▲]

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See detailPhotometric accuracy - The impact of extrapolation in differing color-transformation schemes
Manfroid, Jean ULg; Sterken, C.; Gosset, Eric ULg

in Astronomy and Astrophysics (1992), 264

We discuss photometric errors that arise from the use of differing color-transformation schemes when extrapolating outside the range of the standard values that define the system. An example based on data ... [more ▼]

We discuss photometric errors that arise from the use of differing color-transformation schemes when extrapolating outside the range of the standard values that define the system. An example based on data from the Long-Term Photometry of Variables project (LTPV) at ESO is analyzed. Practically, the extrapolation errors are most evident as systematic brightness jumps of some program stars, seen when monitored over several observing runs. Conclusions are drawn about the choice of standard stars in the Stromgren system. [less ▲]

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See detailThe influence of blood transfusion on brain blood flow autoregulation among stable preterm infants.
RAMAEKERS, Vincent ULg; Casaer, P.; Daniels, H. et al

in Early human development (1992), 30(3), 211-20

Prior to and 24 h following blood transfusion serial determinations of both cerebral artery flow velocity waveforms and mean arterial blood pressure have been used to reconstruct the autoregulatory curve ... [more ▼]

Prior to and 24 h following blood transfusion serial determinations of both cerebral artery flow velocity waveforms and mean arterial blood pressure have been used to reconstruct the autoregulatory curve and its upper blood pressure limit among five stable preterm infants. Prior to transfusion the autoregulatory range of cerebral blood flow (CBF) was narrow due to a relatively low-set upper blood pressure limit. At 24 h after transfusion each individual has been re-examined. Following correction of anemia both a significant reduction of CBF velocities as well as a concomitant rise of the Pulsatility Index (PI) occurred over the entire range of blood pressures indicating a reduction of CBF after transfusion. In addition a right-sided shift of the upper limit towards higher mean blood pressures occurred after transfusion and resulted in an extension of the autoregulatory plateau of CBF. These favourable effects of blood transfusion ameliorating autoregulation of brain blood flow particularly at higher blood pressures might well bear important therapeutic perspectives in our effort to prevent intracranial haemorrhage among sick preterm infants. [less ▲]

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See detailEpidemiological Evaluation of a Monoclonal Elisa Detecting Bovine Viral Diarrhoea Pestivirus Antigens in Field Blood Samples of Persistently Infected Cattle
Mignon, Bernard ULg; Waxweiler, Sophie; Thiry, Etienne ULg et al

in Journal of Virological Methods (1992), 40(1), 85-93

An enzyme-linked immunosorbent assay (ELISA), using monoclonal antibodies for capture and detection, was developed for detecting bovine viral diarrhoea virus (BVDV) antigens in blood samples. The test was ... [more ▼]

An enzyme-linked immunosorbent assay (ELISA), using monoclonal antibodies for capture and detection, was developed for detecting bovine viral diarrhoea virus (BVDV) antigens in blood samples. The test was evaluated using 761 field samples of known status (viraemic or not). When an appropriate cut-off value was chosen, the sensitivity, specificity, and predictive values of the assay were 100%, higher than the values obtained by classical virus isolation. Correlation with the latter technique exceeded 90%. The ELISA is a good candidate for replacing virus isolation as a reference method for BVDV antigen detection in persistently infected carriers. A method based on the mean of the standard deviation ratio can be used to choose the cut-off value in order to optimise reproducibility. [less ▲]

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See detailInduction of a Streptomyces Cacaoi Beta-Lactamase Gene Cloned in S. Lividans
Lenzini, V. M.; Magdalena, J.; Fraipont, Claudine ULg et al

in Molecular & General Genetics [=MGG] (1992), 235(1), 41-8

The previously cloned class A beta-lactamase gene (bla) of Streptomyces cacaoi was shown to be inducible by beta-lactam compounds in the host organism S. lividans. A regulatory region of 2.75 kb was ... [more ▼]

The previously cloned class A beta-lactamase gene (bla) of Streptomyces cacaoi was shown to be inducible by beta-lactam compounds in the host organism S. lividans. A regulatory region of 2.75 kb was identified and the nucleotide sequence determined. It contained four open reading frames (ORFs) of which only two were complete and required for induction. ORF1-ORF2 exerted a positive regulatory effect on the expression of bla. Inactivation of ORF1 or of ORF2 resulted not only in the loss of induction, but also in a 30- to 60-fold decrease in the basal (non-induced) level of beta-lactamase production. ORF1 codes for a DNA-binding protein related to the AmpR repressor/activator, which controls the expression of ampC (class C beta-lactamase) genes in several Enterobacteria. [less ▲]

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See detailGenetic Relationships between Bovine Herpesvirus 4 and the Gammaherpesviruses Epstein-Barr Virus and Herpesvirus Saimiri
Bublot, M.; Lomonte, P.; Lequarré, Anne-Sophie ULg et al

in Virology (1992), 190(2), 654-65

The overall arrangement of genes in the unique central part of the bovine herpesvirus type 4 (BHV-4) genome has been deduced by analysis of short DNA sequences. Twenty-three genes conserved in at least ... [more ▼]

The overall arrangement of genes in the unique central part of the bovine herpesvirus type 4 (BHV-4) genome has been deduced by analysis of short DNA sequences. Twenty-three genes conserved in at least one of the completely sequenced herpesviruses have been identified and localized. All of these genes encoded amino acid sequences with higher similarity to proteins of the gammaherpesviruses Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simplex virus type 1 or the betaherpesvirus human cytomegalovirus. The genome organization of BHV-4 had also an overall colinearity with that of the gammaherpesviruses EBV and HVS. Furthermore, the BHV-4 genes content and arrangement were more similar to those of HVS than to those of EBV, suggesting that BHV-4 and HVS are evolutionarily more closely related to each other than either are to EBV. BHV-4 DNA sequences were generally deficient in CpG dinucleotide. This CpG deficiency is characteristic of gammaherpesvirus genomes and suggests that the BHV-4 latent genome is extensively methylated. Despite several biological features similar to those of betaherpesviruses, BHV-4 displays the molecular characteristics of the representative members of the gammaherpesvirinae subfamily. [less ▲]

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See detailLa péricardite tuberculeuse: intérêt du dosage de l'activité de l'adénosine déaminase
Letiexhe, Michel ULg; Pierard, Luc ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1992), 47(10), 502-9

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See detailSequence of the Subtilisin-Encoding Gene from an Antarctic Psychrotroph Bacillus Ta41
Davail, S.; Feller, Georges ULg; Narinx, E. et al

in Gene (1992), 119(1), 143-4

The nucleotide sequence of the subtilisin-encoding gene from the antarctic psychrotroph, Bacillus TA41, was determined. The primary structure of the subtilisin precursor corresponds to a preproenzyme of ... [more ▼]

The nucleotide sequence of the subtilisin-encoding gene from the antarctic psychrotroph, Bacillus TA41, was determined. The primary structure of the subtilisin precursor corresponds to a preproenzyme of 419 amino acids. Asp144, His181 and Ser359 are the proposed catalytic residues of the protease active site. [less ▲]

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See detailStabilization of T7-Promoter-Based Parhs Expression Vectors Using the Parb Locus
De Moerlooze, L.; Struman, Ingrid ULg; Renard, Andre et al

in Gene (1992), 119(1), 91-3

We describe a modification of the pAR3040 vector which results in its efficient stabilization during cell division. The parB locus of the plasmid R1 was introduced into the plasmid, pAR3040, to construct ... [more ▼]

We describe a modification of the pAR3040 vector which results in its efficient stabilization during cell division. The parB locus of the plasmid R1 was introduced into the plasmid, pAR3040, to construct the pARHS vectors. These vectors are stable for at least 60 cell generations, even in the absence of selection by an antibiotic present in the culture media, both with or without IPTG induction. [less ▲]

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See detailThe outstanding photometric variations of the Ap star HD 7676 = VV Scl
Renson, Pierre ULg; Manfroid, Jean ULg

in Astronomy and Astrophysics (1992), 263

Contrary to what was formerly believed, VV Scl is not an eclipsing star but an Alpha CVn type variable with period P = 5.0976 +/- 0.0001 d. The range of the luminosity variation is remarkably large for an ... [more ▼]

Contrary to what was formerly believed, VV Scl is not an eclipsing star but an Alpha CVn type variable with period P = 5.0976 +/- 0.0001 d. The range of the luminosity variation is remarkably large for an Ap star, especially in B of Johnson's system, and in b and mostly in v of Stromgren's one. A secondary minimum appears near the maximum in B, b, an v. The main minima are in phase in all colors. [less ▲]

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See detailUltraviolet imaging of the Jovian aurora with the Hubble Space Telescope
Dols, V.; Gérard, Jean-Claude ULg; Paresce, F. et al

in Geophysical Research Letters (1992), 19

We present here for the first time a Lyman-alpha image of the north polar region of Jupiter obtained with the Faint Object Camera on board the Hubble Space Telescope a few hours after the encounter of the ... [more ▼]

We present here for the first time a Lyman-alpha image of the north polar region of Jupiter obtained with the Faint Object Camera on board the Hubble Space Telescope a few hours after the encounter of the ULYSSES spacecraft with Jupiter. The presence of high latitude regions of enhanced emission is clearly observed. A comparison with the location of the 'UVS oval', the Io (L = 6) and high-latitude field-line footprints shows that the best agreement is obtained with the L not less than 15 footprint and the UVS oval which are close to each other for the particular longitudinal sector observed. These two L-shells correspond to two possible sources of precipitation: particles originating respectively from the region of the plasma torus of Io in a distorted magnetic field or particles from the distant magnetosphere by analogy with the terrestrial aurora. [less ▲]

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See detailEffect of estradiol supplementation on superovulation in swamp buffalo
Uoc, N. T.; Nguyen, B. X.; Ty, L. V. et al

in Theriogenology (1992), 38(3), 471-478

The effect of estradiol-17β (E2) supplementation on superovulation with (PMSG) or (FSH) was investigated in Swamp buffalo. Sixty-eight buffalo were treated in seven groups. Group 1 served as control and ... [more ▼]

The effect of estradiol-17β (E2) supplementation on superovulation with (PMSG) or (FSH) was investigated in Swamp buffalo. Sixty-eight buffalo were treated in seven groups. Group 1 served as control and was superovulated by standard PMSG or FSH treatment used in routine bovine embryo transfer protocols. Group 2 was superovulated by standard PMSG regimen plus two injections of E2 at a 48 h interval beginning one day before the onset of gonadotropin treatment (short-term supplementation) for a total dosage of 2.5 mg E2; Groups 3 and 4 received the same regimen as Group 2, but in doses of 5.0 and 7.5 mg E2, respectively. Group 5 received the standard FSH regimen (40% LH). Group 6 received short-term E2 (7.5 mg) supplementation of FSH-p. Group 7 was superovulated by standard FSH regimen (40% LH) plus three injections of E2 at 48–72 h intervals beginning five days before the onset of gonadotropin treatment (long-term supplementation) for a total dosage of 7.5 mg E2. The number of corpora lutea (CL) and follicles ≥ 8 mm in diameter were recorded by palpation per rectum and after slaughter. The mean numbers of CL and follicles were 0.99, 5.8, 8.0, 10.6, 4.0, 3.9, 8.1 and 0.25, 6.8, 6.2, 6.2, 1.6, 0.0, 4.1 for Groups 1, 2, 3, 4, 5, 6, 7, respectively. In Group 7, the rates of nonsurgical and postmortem embryo recovery were 46 and 90.4%, respectively and 54.4% of the collected ova were fertilized. These results indicate the possibility of producing viable embryos in buffalo by using E2 supplementation for the gonadotropin treatment. [less ▲]

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See detailEnseigner l'holocauste
Jadoulle, Jean-Louis ULg

in Bulletin de Clio (1992), n°94

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See detailPresurgical octreotide treatment in acromegaly.
Stevenaert, Achille ULg; Harris, A. G.; Kovacs, K. et al

in Metabolism : Clinical and Experimental (1992), 41(9 Suppl. 2), 51-8

The aim of this study was to determine the role of octreotide administration in acromegalic patients as a preparation for selective adenomectomy using transsphenoidal route. Octreotide was administered ... [more ▼]

The aim of this study was to determine the role of octreotide administration in acromegalic patients as a preparation for selective adenomectomy using transsphenoidal route. Octreotide was administered for 3 to 6 weeks before surgery in 12 patients and for 4 to 39 months in 25 patients. The clinical response was judged as excellent or good in 10 of 12 patients from group I and in 23 of 25 patients from group II. Marked reduction (ie, greater than 50% of initial values) in serum growth hormone (GH) levels was seen in all patients, with levels to less than 5 micrograms/L in 68% of patients and less than 2 micrograms/L in 27%. Insulin-like growth factor 1 (IGF-1) levels decreased to within normal limits in half the cases. During long-term treatment, an escape phenomenon could be seen. Varying degrees of tumor shrinkage were seen in more than 50% of cases. During surgery, with regard to the relative ease or difficulty in removing the tumor, the consistency of the tumor and the separation of normal from pathological tissue, no significant difference was observed between patients given octreotide and those from control series. Morphological changes in adenomatous tissue were rather small. The surgical outcome was similar in the pretreated series as in the control series, except in enclosed adenomas, which showed a tendency to a higher success rate. Since octreotide improves both the clinical condition and hormonal parameters and induces varying degrees of tumor shrinkage, it is potentially useful as an adjunct to surgery. Morphological data suggest that octreotide exercises a functional inhibitory effect on GH release. [less ▲]

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See detailThe Human Placenta Becomes Haemochorial at the 13th Week of Pregnancy
Foidart, Jean-Michel ULg; Hustin, Jean-Michel; Dubois, Michel ULg et al

in International Journal of Developmental Biology (1992), 36(3), 451-3

Histological specimens of recent implantation sites are the basis of our current concept on human embryo implantation and placental development. In the Carnegie Collection maternal red blood cells were ... [more ▼]

Histological specimens of recent implantation sites are the basis of our current concept on human embryo implantation and placental development. In the Carnegie Collection maternal red blood cells were detected early in the primitive intervillous space (10th-12th day after conception). These cells were localized to the trophoblastic lacunae and originated from distended peripheral maternal sinusoids (Kaufmann, 1981). The classical theory states that progressively more and more maternal vessels are tapped. A true maternal blood flow is established around the 29th day. Dynamic investigations of human placental development in vivo are scarce and hampered by ethical considerations and the absolute requirement to refrain from using non aggressive and potentially harmful techniques. Despite these limitations such studies provide new insights that surprisingly contradict our previously and seemingly definitely established knowledge of the early phases of placental vascularization, and lead us to conclude that there is an absence of maternal blood circulation in the intervillous placental space (IVS) during the 12 first weeks of human pregnancy. [less ▲]

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See detailSinglet Oxygen Quantum Yield of Sulfur and Selenium Analogs of Psoralen
Seret, Alain ULg; Piette, Jacques ULg; Jakobs, Andréas et al

in Photochemistry and Photobiology (1992), 56(3), 409-412

The quantum yield of singlet oxygen production by eight newly synthesized sulfur and selenium analogs of psoralen irradiated with UV-A (366 nm) has been determined in CCl4 with the help of the steady ... [more ▼]

The quantum yield of singlet oxygen production by eight newly synthesized sulfur and selenium analogs of psoralen irradiated with UV-A (366 nm) has been determined in CCl4 with the help of the steady state luminescence technique. The new psoralen derivatives are generally better singlet oxygen producers than psoralen itself. In particular, the replacement of selenophene for furan and/or of thiopyrone for pyrone induces an important enhancement of the singlet oxygen quantum yield. [less ▲]

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See detailTransdiaphragmatic Pressure Measurement in Cattle: Technical Data
Desmecht, Daniel ULg; Rollin, Frédéric ULg; Lekeux, Pierre ULg

in Research in Veterinary Science (1992), 53(2), 148-53

Techniques and methods required for accurate and reproducible measurements of transdiaphragmatic pressure (Pdi), were studied in seven-week and five-month-old calves. Since reliable pleural pressure ... [more ▼]

Techniques and methods required for accurate and reproducible measurements of transdiaphragmatic pressure (Pdi), were studied in seven-week and five-month-old calves. Since reliable pleural pressure measurement in cattle has already been described, separate experiments were conducted to compare retrodiaphragmatic pressures measured (i) with balloon-catheters and needle catheters, (ii) before and after eructation and (iii) in the ruminal and in the peritoneal cavities. Whereas respiratory-induced pressure changes were equally transmitted throughout the rumen content, a marked anteroposterior damping was observed as the recording site in the abdominal cavity was moved away from the diaphragm (P < 0.0001). It was concluded that the most appropriate and accurate way to measure Pdi changes in polygastric animals is to measure the pressure changes existing in the mid-thoracic portion of the oesophagus and in the liquid content of the rumen with balloon-tubing units. Neither growth- and diet-related rumen enlargement nor eructation, which are two typical characteristics of ruminants, altered the reliability of retrodiaphragmatic pressure measurements in the two age groups studied. [less ▲]

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See detailDetection of the Photoactive Protochlorophyllide-Protein Complex in the Light During the Greening of Barley
Franck, Fabrice ULg; Strzalka, K.

in FEBS Letters (1992), 309(1), 73-7

A photoactive protochlorophyllide-protein complex with absorbance and fluorescence maxima at 648 and 653 nm was detected in greening barley leaves without any re-darkening. The variations of the ... [more ▼]

A photoactive protochlorophyllide-protein complex with absorbance and fluorescence maxima at 648 and 653 nm was detected in greening barley leaves without any re-darkening. The variations of the amplitudes of the absorbance and the fluorescence of the photoactive protochlorophyllide with greening time at two different light intensities indicate a close relationship between the rate of chlorophyll synthesis and the amount of the complex during the first hours. The chlorophyllide resulting from photoreduction during greening has an absorbance maximum at 684 nm, which shifts towards a shorter wavelength within a few seconds, indicating rapid liberation of the pigment from the enzyme. We conclude that chlorophyll accumulation proceeds through continuous regeneration and phototransformation of the photoactive complex. [less ▲]

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See detailMacromolecular engineering of polylactones and polylactides. 9. Synthesis, characterization, and applications of omega-primary amine poly(ε-caprolactone)
Degée, Philippe; Dubois, Philippe; Jérôme, Robert ULg et al

in Macromolecules (1992), 25

The synthesis and use of functional diethylaluminum alkoxides (Et2AlORX) as initiators for the ring-opening polymerization of ε-caprolactone have been investigated as a possible strategy to prepare omega ... [more ▼]

The synthesis and use of functional diethylaluminum alkoxides (Et2AlORX) as initiators for the ring-opening polymerization of ε-caprolactone have been investigated as a possible strategy to prepare omega-primary amino poly(ε-caprolactone) (PCL). In a first approach, an initiator containing ethylphthalimide as the functional-RX group has been synthesized. That protected amino group has been successfully attached at the end of PCL chains. The conversion of the phthalimide end group into a primary amine has however failed, whatever the experimental conditions. In an alternative approach, an alkyl bromide has been considered as the functional group to be attached to PCL chains, via the appropriate initiator. The end functionalization was quantitative and the bromo end group converted into an azido group which was subsequently reduced to the expected primary amine. Omega-primary amino PCL has proved to be an effective macroinitiator for the ring-opening polymerization of γ-benzylglutamate N-carboxy anhydride with the formation of a poly(caprolactone-b-peptide) diblock copolymer. [less ▲]

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See detailRadiosensitizing and repair-inhibiting properties of dipyridamole.
COUCKE, Philippe ULg; Rutz, H-P; Calmes, J-M et al

in Radiotherapy & Oncology (1992), 24(24), 246-250

Radioresistance and postirradiation repair of potentially lethal damage (PLD repair) are important factors underlying failure to control local disease in cancer. Dipyridamole (DP) is known as a modifier ... [more ▼]

Radioresistance and postirradiation repair of potentially lethal damage (PLD repair) are important factors underlying failure to control local disease in cancer. Dipyridamole (DP) is known as a modifier of the action of cytotoxic drugs. We therefore investigated DP as a potential radiosensitizer and inhibitor of PLD repair in X-irradiated Chinese hamster ovary (CHO) cells in vitro. Exposure to the drug alone resulted in a slight reduction of the clonogenic capacity of the cells. Preincubation for 18 h with 10 and 20 microM DP in cells subcultured at low density, led to a significant radiosensitization. In confluent density-inhibited cultures, preincubation alone as well as pre- and postincubation with 20 microM DP resulted in a significant inhibition of PLD repair. Dipyridamole and related compounds may thus be useful tools for modifying and investigating the response of mammalian cells to radiation. [less ▲]

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See detailExperimental Acute Traumatic Injury of the Adult Rat Spinal Cord by a Subdural Inflatable Balloon: Methodology, Behavioral Analysis, and Histopathology
Martin, Didier ULg; Schoenen, Jean ULg; Delree, P. et al

in Journal of Neuroscience Research (1992), 32(4), 539-50

We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to ... [more ▼]

We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of compression or the volume of saline used to inflate the balloon. The locomotor deficit of animals with various degrees of injury has been assessed at increasing delays after trauma. The parameters generating transient or definitive deficits of varying intensity were defined. Some injured animals underwent nuclear magnetic resonance imaging. Detailed histopathological studies demonstrated that the extent of the spinal lesion was significantly correlated with the physical parameters of compression and with the severity of the behavioral deficit. [less ▲]

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See detailEvaluation of the Efficacy and Safety of Oral Tiludronate in Paget's Disease of Bone. A Double-Blind, Multiple-Dosage, Placebo-Controlled Study
Reginster, Jean-Yves ULg; Colson, F.; Morlock, G. et al

in Arthritis & Rheumatism : Arthritis Care & Research (1992), 35(8), 967-74

OBJECTIVE. To assess the optimal dosage of oral tiludronate in Paget's disease of bone. METHODS. We studied 149 patients with Paget's disease, in a double-blind, randomized, placebo-controlled trial ... [more ▼]

OBJECTIVE. To assess the optimal dosage of oral tiludronate in Paget's disease of bone. METHODS. We studied 149 patients with Paget's disease, in a double-blind, randomized, placebo-controlled trial. Patients were randomly assigned to 1 of 5 therapeutic groups: a daily dose of 100 mg, 200 mg, 400 mg, or 800 mg of oral tiludronate, or a placebo. Treatment was for 3 months, followed by 3 months of placebo-controlled followup. Serum alkaline phosphatase activity (SAP) and fasting urinary excretion of hydroxyproline/creatinine (OH/Cr) were measured monthly, as were biochemical parameters reflecting renal, hepatic, and hematologic functions. Analgesic efficacy was self-evaluated from a visual analog scale and a global pain index. RESULTS. Statistical analysis revealed that beginning at a dosage of 200 mg/day, there was a direct dose-dependent effect on the reduction of SAP and OH/Cr levels. Reduction of SAP levels was clinically significant at a dosage of 400 mg (44.9 +/- 4.2% reduction at 90 days and 49.2 +/- 4.5% at 180 days, mean +/- SEM) and at 800 mg (53.4 +/- 5% at 90 days and 59.3 +/- 4.6% at 180 days). There was a significant reduction in pain in all groups, including the group taking placebo. In only those taking 800 mg/day of tiludronate was there a significant frequency of complete resolution of pain (versus placebo). Aside from mild gastrointestinal disturbances, as experienced with other oral bisphosphonates, clinical tolerance of all 5 regimens was good. Exhaustive biochemical investigations failed to reveal significant toxicity of tiludronate up to the 800-mg daily dose investigated. CONCLUSION. Because of its significantly better antiresorptive effects and greater analgesic properties (compared with lower dosages), combined with the excellent clinical and biochemical tolerance, the 800-mg daily dose of tiludronate appears to be optimal for the treatment of Paget's disease of bone. [less ▲]

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See detailFlow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents
Snoeck, R.; Schols, D.; Sadzot-Delvaux, Catherine ULg et al

in Journal of Virological Methods (1992), 38(2), 243-254

Varicella zoster virus (VZV) is responsible for a primary infection (varicella.) and, upon reactivation, zoster, which in immunocompromised patients, may both lead to life-threatening disseminated disease ... [more ▼]

Varicella zoster virus (VZV) is responsible for a primary infection (varicella.) and, upon reactivation, zoster, which in immunocompromised patients, may both lead to life-threatening disseminated disease. There is a great need for antiviral compounds that are effective inhibitors of VZV replication and for rapid and accurate methods for evaluating viral sensitivity to candidate anti-VZV drugs. With the monoclonal antibody (mAb) (VL8), which is directed against the gpI of VZV, and using the fluorescence-activated cell sorter (FACS) we could readily demonstrate expression of the VZV gpI antigen at 3-4 days after VZV infection. (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and (S)-1-(3-hydro-xy-2-phosphonylmethoxypropyl)cytosine (HPMC) were shown to be potent inhibitors of VZV replication by this assay. HPMPA and HPMPC were also active against thymidine kinase-deficient (TK-) VZV whereas BVDU was not. The flow cytometric method based on the use of mAb VL8 may be of considerable help for the early diagnosis of VZV infection and evaluation of viral sensitivity to antiviral drugs. [less ▲]

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See detailLe trou d'ozone et son impact sur la chronobiologie. Sommes-nous directement concernés?
Nikkels, Arjen ULg; Gerardy-Goffin, F.; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (1992), 47(8), 415-418

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See detailAldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus.
Beckers, Albert ULg; Abs, R.; van der Auwera, B. et al

in Journal of Clinical Endocrinology and Metabolism (1992), 75(2), 564-70

A 63-year-old female presented with the extremely rare occurrence of an aldosterone-secreting adrenocortical adenoma as part of the syndrome of multiple endocrine neoplasia type 1 (MEN1). Only two other ... [more ▼]

A 63-year-old female presented with the extremely rare occurrence of an aldosterone-secreting adrenocortical adenoma as part of the syndrome of multiple endocrine neoplasia type 1 (MEN1). Only two other MEN1 patients were reported in the literature with hyperaldosteronism. The patient's MEN1 syndrome consisted of the association of primary hyperparathyroidism due to parathyroid adenoma, a prolactinoma, and a toxic multinodular goiter. Elevated basal and meal-stimulated serum PP levels without demonstrable pancreatic tumor were also found. Genetic analysis of the aldosterone-secreting adenoma with DNA markers localized on chromosome 11 showed loss of heterozygosity in tumor DNA. Since the MEN1 syndrome is caused by loss of the tumor suppressor gene on chromosome 11 in the 11q13 region, it is probable that the same mechanism is associated with the formation of the adrenocortical adenoma. [less ▲]

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See detailImpairment of renal function with increasing blood lead concentrations in the general population
Staessen, Jan; Lauwerys, Robert; Buchet, Jean-Pierre et al

in New England Journal of Medicine [=NEJM] (1992), 327(3), 151-156

Cadmium and lead are toxic to the kidney. Both metals are known to induce nephropathy in subjects with heavy exposure. Environmental exposure to cadmium is associated with renal tubular dysfunction, but ... [more ▼]

Cadmium and lead are toxic to the kidney. Both metals are known to induce nephropathy in subjects with heavy exposure. Environmental exposure to cadmium is associated with renal tubular dysfunction, but few studies have attempted to evaluate the renal effects of environmental lead exposure. A weak positive correlation between serum creatinine and blood lead concentrations was found in men, but not women, in the British civil service. We investigated the relation between lead exposure and renal function in the general population, using data obtained during the Cadmibel (Cadmium in Belgium) Study. Lead exposure was estimated by measuring blood concentrations of lead and zinc protoporphyrin, which is increased in the presence of high lead levels. [less ▲]

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See detailLiving (co)polymerization of adipic anhydride and selective end functionalization of the parent polymer
Ropson, Nathalie; Dubois, Philippe; Jérôme, Robert ULg et al

in Macromolecules (1992), 25(14), 3820-3824

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See detailErrata au Bulletin d'Information 40
Renson, Pierre ULg

in Bulletin d'Information du Centre de Données Stellaires (1992), 41

Not Available

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See detailPhysical constraints on color transformations
Manfroid, Jean ULg

in Astronomy and Astrophysics (1992), 260

Color-transformation procedures in photometry should ideally obey physical principles. A few of these rules, of particular interest in the study of reddened stars, of multiple stars, stellar clusters and ... [more ▼]

Color-transformation procedures in photometry should ideally obey physical principles. A few of these rules, of particular interest in the study of reddened stars, of multiple stars, stellar clusters and galaxies are discussed. Directions to minimize the transformation errors for these objects are given. [less ▲]

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See detailSolar system observations with HST
Paresce, Francesco; Gérard, Jean-Claude ULg

in Environment Observation and Climate Modelling Through International Space Projects (1992)

Imaging and spectrographic measurements of solar system objects with the Hubble Space Telescope (HST) are reviewed from a scientific and technical standpoint. Special emphasis is placed on observations of ... [more ▼]

Imaging and spectrographic measurements of solar system objects with the Hubble Space Telescope (HST) are reviewed from a scientific and technical standpoint. Special emphasis is placed on observations of Jupiter and Io during the Ulysses encounter by the Faint Object Camera and HRS. The bottom line is that, although the mirror aberration limits HST's extragalactic performance, the potential for a deep systematic probe of planetary conditions over a wide range of observing conditions is still practically intact and will get better as the bugs are ironed out and the COSTAR (Corrective Optics Space Telescope Axial Replacement) fix is implemented. [less ▲]

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See detailSite-Directed Mutagenesis of the Streptomyces R61 Dd-Peptidase. Catalytic Function of the Conserved Residues around the Active Site and a Comparison with Class-a and Class-C Beta-Lactamases
Hadonou, Ayaovi Medard; Wilkin, Jean-Marc; Varetto, Louis ULg et al

in European Journal of Biochemistry (1992), 207(1), 97-102

The importance of various residues in the Streptomyces R61 penicillin-sensitive DD-peptidase has been assessed by site-directed mutagenesis. The replacement of the active Ser62 by a Cys residue yielded an ... [more ▼]

The importance of various residues in the Streptomyces R61 penicillin-sensitive DD-peptidase has been assessed by site-directed mutagenesis. The replacement of the active Ser62 by a Cys residue yielded an inactive protein which was also unable to recognize penicillin. The activity of the Lys65 → Arg mutant with the peptide and thiol ester substrates was decreased 100-200-fold and the rate of penicillin inactivation was decreased 20 000-fold or more. The mutant thus behaved as a poor, but penicillin-resistant, DD-peptidase. The other studied mutations, the mutations Phe358 → Leu, Tyr90 → Asn, Thr101 → Asn, Phe164 → Ala, Asp225 → Glu and Asp225 → Asn had little influence on the catalytic and penicillin-binding properties. The Asp225 mutants did not exhibit an increased sensitivity to cefotaxime. The Phe164 → Ala mutant was significantly more unstable than the wild-type enzyme. [less ▲]

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See detailLow sodium diet in essential hypertension- Effect on blood cell ions and hemodynamic parameters
Krzesinski, Jean-Marie ULg; Du, Fenghe; Pequeux, Marie-Louise et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (1992), 5

The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight ... [more ▼]

The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight untreated essential hypertensive patients. A low salt diet decreases blood pressure, vascular resistances, erythrocyte sodium, and platelet calcium, but not platelet pH. A strong positive correlation was noted between baseline platelet calcium and vascular resistances (r=0.95, P < .01). But during the salt restriction period, a negative correlation has been observed between the changes in these parameters, which casts doubt on the use of the platelet as a mode of the smooth muscle cell. [less ▲]

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See detailInternal mammary artery bypass graft for impaired coronary perfusion after neonatal arterial switch operation
Grabitz, R. G.; Messmer, B. J.; SEGHAYE, Marie-Christine ULg et al

in European Journal of Cardio - Thoracic Surgery (1992), 6(7), 388-90

Myocardial ischaemia caused by perfusion impairment of translocated coronary arteries is the major cause of perioperative mortality after neonatal arterial switch operation for transposition of the great ... [more ▼]

Myocardial ischaemia caused by perfusion impairment of translocated coronary arteries is the major cause of perioperative mortality after neonatal arterial switch operation for transposition of the great arteries. We report the successful use of the right internal mammary artery as a bypass graft to a dominant right coronary artery to treat insufficient perfusion of this artery in a newborn. Eight months later, coronary angiography showed a full blood supply of the right coronary artery across the internal mammary anastomosis. After a follow-up period of more than 30 months, somatic development, electrocardiogram and echocardiographically determined contractility of both ventricles are practically normal indicating regular function of the bypass graft. [less ▲]

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See detailPressure-Flow Relationships of the Pulmonary Circulation During Endotoxin Infusion in Intact Dogs
D'Orio, Vincenzo ULg; Fatemi, M.; Marnette, J. M. et al

in Critical Care Medicine (1992), 20(7), 1005-13

BACKGROUND AND METHODS: We aimed to characterize the effects of an endotoxin insult (Escherichia coli 0127:B8) on the relationships between pulmonary vascular pressure and flow in intact dogs. To achieve ... [more ▼]

BACKGROUND AND METHODS: We aimed to characterize the effects of an endotoxin insult (Escherichia coli 0127:B8) on the relationships between pulmonary vascular pressure and flow in intact dogs. To achieve this goal, multipoint plots of total pressure gradient, arterial pressure gradient, and venous pressure gradient vs. flow were generated by graded inflation of a right atrial balloon, which was used to vary flow. The partitioning of the total pressure decrease across the pulmonary vasculature (total pressure gradient = pulmonary arterial pressure-pulmonary artery occlusion pressure [PAOP]) into gradients across pulmonary arterial (arterial pressure gradient = pulmonary arterial pressure--effective capillary pressure) and pulmonary venous (venous pressure gradient = effective capillary pressure--PAOP) regions was assessed by a waveform mathematical analysis of the pulmonary arterial pressure profile during arterial occlusion, with computation of both PAOP and effective pulmonary capillary pressures. Slopes and extrapolated pressure intercepts from linear regression fits to the pulmonary vascular pressure/flow plots were determined in seven dogs after a 2-hr endotoxic infusion interval and were compared with the corresponding values that characterized a similar group of sham-operated dogs. RESULTS: Under normal conditions, the extrapolated pressure intercept for pulmonary arterial pressure gradient was virtually 0 mm Hg; for total pulmonary arterial pressure gradient and pulmonary venous pressure gradient, the mean extrapolated pressure intercepts were substantially positive: 2.4 +/- 0.2 and 2.1 +/- 0.3 mm Hg, respectively. Endotoxin infusion at 0.25 micrograms/kg/min significantly increased the pressure intercepts from 2.4 to 8.7 and from 2.1 to 8.3 mm Hg of total pressure gradient and venous pressure gradient vs. flow, respectively. This infusion produced a minor, nonsignificant change in the intercept of arterial pressure gradient vs. flow, whereas it increased its slope significantly (p less than .05) from 0.036 to 0.081 mm Hg/mL/min/kg. CONCLUSIONS: These data suggest that endotoxin's effects on vascular resistance are exerted at two different loci such that these effects are additive. These endotoxin-induced effects consisted of increased vascular resistance of the arterial segment and appearance of a Starling resistor at the venous side of the pulmonary circulation, which acted as the relevant back-pressure to flow. [less ▲]

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See detailRegional Brain Glucose Metabolism in Patients with Complex Partial Seizures Investigated by Intracranial Eeg
Sadzot, Bernard ULg; Debets, R. M.; Maquet, Pierre ULg et al

in Epilepsy Research (1992), 12(2), 121-9

We performed interictal 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18FDG-PET) studies in 57 patients with complex partial epilepsy (CPE), not controlled by medical treatment and ... [more ▼]

We performed interictal 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18FDG-PET) studies in 57 patients with complex partial epilepsy (CPE), not controlled by medical treatment and considered for surgical resection of their epileptic focus. A precise localization of the epileptic focus was obtained in 37 of these patients with a combination of subdural and depth electrodes. We visually inspected the metabolic images; we also measured glucose consumption in a number of brain regions and compared the values with those obtained in 17 normal controls. Eighty-two percent of the 57 patients had an area of glucose hypometabolism on the 18FDG-PET images. Six patients had a frontal epileptic focus, 3 of them had a frontal lobe hypometabolism. Twenty-six patients had a unilateral temporal lobe focus and all of them displayed a temporal lobe hypometabolism. The asymmetry was more pronounced in the lateral temporal cortex (-20%) than in the mesial part of the temporal lobe (-9.6%). In each cortical brain region on the side of the epileptic focus (except the sensorimotor cortex), glucose consumption rate was lower than in the contralateral region or than in controls. No differences could be found between patients with a seizure onset restricted to the hippocampus and patients with a seizure onset involving the hippocampus and the adjacent neocortex. Divergent metabolic patterns were obtained in 5 patients with bilateral temporal seizure foci. Combined with other non invasive techniques (EEG, neuroradiology), PET contributes increasingly to the selection of patients with CPE who could benefit from surgical treatment.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailEffect of Positive End-Expiratory Pressure on Pulmonary Vascular Pressure-Flow Characteristics in Canine Endotoxin Shock
D'Orio, Vincenzo ULg; Fatemi, M.; Mendes, P. et al

in Circulatory Shock (1992), 37(3), 189-97

The vascular pulmonary pressure-flow (P-Q degree) relationships were studied in anesthetized dogs in order to characterize the distribution of total resistance in the pulmonary bed with respect to ... [more ▼]

The vascular pulmonary pressure-flow (P-Q degree) relationships were studied in anesthetized dogs in order to characterize the distribution of total resistance in the pulmonary bed with respect to incremental resistance and critical closure prior to and after endotoxin insult. Incremental resistance was computed as the slope of the P-Q degree relation, whereas critical closure was referred to as the extrapolated pressure intercept at zero flow. P-Q degree coordinates were obtained by varying Q degree through graded inflation of right atrial balloon. The gradients across the arterial segment (Pa = Ppa - Pc) and across the venous segment (Pv = Pc - Pw) of the pulmonary vasculature were defined by the computation of effective capillary pressure (Pc) obtained from the analysis of the transient decay of pulmonary artery pressure (Ppa) toward wedge pressure (Pw) after arterial occlusion. Six group E dogs were infused with endotoxin at a rate of 0.25 microgram/kg min, while six additional animals served as control (group C). Endotoxin induced increases in flow resistance from 0.056 to 0.096 mm Hg/ml/min/kg due to arterial vasoconstriction and increases in critical closure from 2.3 to 8.4 mm Hg due to a venous waterfall. Before and after endotoxin insult, we assessed effects of each of three levels of static lung inflation (PEEP) on P-Q degree relationships.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailUn nouvel atout dans la lutte antifongique : Bacillus subtilis.
Vanhentenryck, F.; Jacques, Ph.; Thonart, Philippe ULg

in Bulletin de liaison FAO (1992), 4

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See detailEffects of repeated use of progestagen-PMSG treatment for estrus control in dairy goats out of breeding season
Baril, Gérard; Remy, Benoît ULg; Vallet, J. C. et al

in Reproduction in Domestic Animals (1992), 27(3), 161-168

Contents: In order to analyze the effects of repeated use of progestagen-PMSG treatment, estrus and pregnancy results have been analyzed for 1989 in a Saânen dairy goat herd in which breeding takes place ... [more ▼]

Contents: In order to analyze the effects of repeated use of progestagen-PMSG treatment, estrus and pregnancy results have been analyzed for 1989 in a Saânen dairy goat herd in which breeding takes place each year out of season after FGA/PMSG treatment. After the first 1989 treatment (169 goats), percentage of goats showing estrus and kidding have been lower for 59 multiparous than for 46 primiparous and 64 nulliparous females. Moreover, when 38 goats are treated for a second time in 1989, 44.7% exhibited estrus vs 71.0% after the first treatment (P < 0.05). The PMSG binding level before the 1st 1989 treatment is higher for multiparous (17.5 ± 23.1%) than nulli and primiparous (-0.06 ± 0.7 and 1.2 ± 1.9%) and is increased for all parities after treatment (23.2 ± 26.4 after vs 5.7 ± 15.0% before, P < 0.01). For nulliparous and primiparous females; PMSG binding levels are not different for pregnant or not pregnant nulliparous and primiparous goats. On the opposite, PMSG binding rates are higher in non pregnant (25.7 ± 23.3) than in pregnant multiparous goats (6.5 ± 15.9) (P < 0.01). However, when the binding rate is ≤ 5.12% (computerized distributions) multiparous goats exhibit estrus and pregnancy at levels not different from nulliparous or primiparous females (% estrus 95.8 vs 100 or 97.8%, % pregnancy 66.7 vs 70.3 and 63.0% respectively). Repeated use of PMSG during the female life or during one given year leads to active immunization against PMSG (as measured by percentage of binding of PMSG in plasma) decreasing the efficiency of ovarian stimulation out of breeding season. [less ▲]

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See detailDesign Method for Subsonic and Transonic Cascade with Prescribed Mach Number Distribution
Léonard, Olivier ULg; Van den Braembusche, René

in Journal of Turbomachinery (1992), 114(3), 553-560

An iterative procedure for blade design, using a time marching procedure to solve the unsteady Euler equations in the blade-to-blade plane, is presented. A flow solver, which performs the analysis of the ... [more ▼]

An iterative procedure for blade design, using a time marching procedure to solve the unsteady Euler equations in the blade-to-blade plane, is presented. A flow solver, which performs the analysis of the flow field for a given geometry, is transformed into a design method. This is done by replacing the classical slip condition (no normal velocity component) by other boundary conditions, in such a way that the required pressure or Mach number distribution may be imposed directly on the blade. The unknowns are calculated on the blade wall using the so-called compatibility relations. Since the blade shape is not compatible with the required pressure distribution, a nonzero velocity component normal to the blade wall evolves from the new flow calculation. The blade geometry is then modified by resetting the wall parallel to the new flow field, using a transpiration technique, and the procedure is repeated until the calculated pressure distribution has converged to the required one. Examples for both subsonic and transonic flows are presented and show a rapid convergence to the geometry required for the desired Mach number distribution. An important advantage of the present method is the possibility to use the same code for the design and the analysis of a blade. [less ▲]

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See detailInfluence Of Extrusion On Ruminal And Intestinal Disappearance In Sacco Of Pea (Pisum-Sativum) Proteins And Starch
Walhain, Philippe; Foucart, Michel; Thewis, André ULg

in Animal Feed Science & Technology (1992), 38(1), 43-55

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See detailStratigraphie du Dévonien inférieur dans le Massif de la Vesdre (Belgique)
Hance, Luc ULg; Dejonghe, L; Steemans, Philippe ULg

in Annales de la Société Géologique de Belgique (1992), 115(1), 119-134

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See detailGonadal-Independent Developmental Changes in Activation of N-Methyl-D-Aspartate Receptors Involved in Gonadotropin-Releasing Hormone Secretion
Bourguignon, Jean-Pierre ULg; Gerard, Arlette ULg; Alvarez Gonzalez, Maria-Luz ULg et al

in Neuroendocrinology (1992), 55(6), 634-41

Using hypothalamic explants of male rats, we have shown that the N-methyl-D-aspartate (NMDA) receptors involved in a stimulatory control of gonadotropin-releasing hormone (GnRH) secretion were transiently ... [more ▼]

Using hypothalamic explants of male rats, we have shown that the N-methyl-D-aspartate (NMDA) receptors involved in a stimulatory control of gonadotropin-releasing hormone (GnRH) secretion were transiently activated at 25 days around the time of onset of puberty. This was evidenced by studying the dose-related inhibition of veratridine-induced GnRH secretion by MK-801, a use dependent antagonist of NMDA receptors. An increase in sensitivity of GnRH secretion to the inhibitory effect of MK-801 was used as a marker of increased activation of NMDA receptors involved in stimulation of GnRH secretion. Here, we report on data obtained in intact and castrated rats at different ages. The aim was to determine whether the absence of gonads would affect the developmental changes in activation of NMDA receptors that we described recently. In pubertal (50-day-old) rats, orchidectomy resulted in an activation of NMDA receptors which was nonsignificant after 4 days but significant after 13 days. In prepubertal rats orchidectomized at 5 or 10 days and studied 10 days later, the NMDA receptors involved in GnRH secretion were also more activated than in intact animals. Using explants of intact and castrated animals, a similar increase in activation of NMDA receptors was observed between 15 and 25 days of age, a period preceding onset of puberty. Subsequently, between 25 and 50 days, a reduction in NMDA receptor activation was seen. This decrease was observed in intact rats showing normal sexual development and in castrated rats as well.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailEndogenous Production of Specific Antibodies Does Not Decrease Hypocalcemic Response to Calcitonin in Young Rabbits
Reginster, Jean-Yves ULg; Azria, M.; Lismonde, Stéphanie ULg et al

in Calcified Tissue International (1992), 50

In order to evaluate the potential inhibition of the acute anti-osteoclastic activity of salmon calcitonin (SCT) by specific antibodies (Ab), we compared the SCT-induced hypocalcemic effect in young male ... [more ▼]

In order to evaluate the potential inhibition of the acute anti-osteoclastic activity of salmon calcitonin (SCT) by specific antibodies (Ab), we compared the SCT-induced hypocalcemic effect in young male rabbits with significant titers of high affinity Ab and in matched animals without Ab. Immunization of rabbits was performed by repetitive s.c. injections of SCT and Freund adjuvant. Ab were present in four-fifths of SCT-treated rabbits (Ab+). Their titer varied from 0.8 x 10(-9) to 30 x 10(-9) M/liter and their constant of affinity from 0.97 x 10(9) to 4.2 x 10(9) L/M. Intravenous injection of 1 IU/kg SCT to Ab+ rabbits induced a significant decrease (P less than 0.01) of ionized serum calcium (Ca2+) after 30 minutes (mean +/- SD: -9 +/- 0.6%) and until the 240th minute of the test (-16.7 +/- 4.7%), with a maximum after 120 minutes (-22.6 +/- 2%). This was not significantly different from the hypocalcemic effect measured after the same procedure performed in matched animals without Ab (Ab-): significant decrease in Ca2+ (P less than 0.01) after 30 minutes (-8.2 +/- 2.2%), maximal after 150 minutes (-23.2 +/- 4.9%), and lasting until 210 minutes (-14.5 +/- 3.7%). We conclude that, in the particular model of the male young rabbit, specific anti-SCT Ab do not block or reduce the acute anti-osteoclastic activity of SCT. [less ▲]

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See detailThe Stimulation of Fibroblasts' Collagen Synthesis by Neoplastic Cells Is Modulated by the Extracellular Matrix
Noël, Agnès ULg; Munaut, Carine ULg; Nusgens, Betty ULg et al

in Matrix (Stuttgart, Germany) (1992), 12(3), 213-20

Human fibroblasts cocultured with neoplastic MCF7 cells produce increased amounts of collagen. A maximal stimulation requires direct cell-cell contacts between tumor cells and fibroblasts. However, this ... [more ▼]

Human fibroblasts cocultured with neoplastic MCF7 cells produce increased amounts of collagen. A maximal stimulation requires direct cell-cell contacts between tumor cells and fibroblasts. However, this effect could be reproduced, although to a lesser extent, by medium conditioned by MCF7 cells, suggesting that it is mediated by a factor produced by MCF7 cells and secreted, at least partly, under a soluble form (Noel et al., 1992). This Collagen Stimulating Factor ("COSF") present in the culture medium displayed a molecular mass between 3,500 to 10,000 daltons, bound to heparin and appeared to be different from the growth factors described until now. The "COSF" can be released from the surface of MCF7 cells by treatment with heparin. The aim of the present work was to investigate the influence of various extracellular matrix components on the production and the release of "COSF". A 3- to 4-fold enhancement of collagen synthesis was observed in coculture on plastic and collagen type I substrates without significant modification of the non-collagen proteins. The increased collagen synthesis was paralleled by an elevation of specific collagen mRNAs level suggesting a regulation at a pretranslational level. On the opposite, in the presence of soluble or insoluble laminin, this stimulation was abolished. Similarly, coculture on "reconstituted basement membrane matrix", matrigel, did not increase collagen production. The "COSF" was found to bind to matrigel and could be released from the basement membrane matrix by treatment with heparin. [less ▲]

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See detailJazz & the Blues : The Belgian Connection
Sacré, Robert ULg

in MAWA Review : Quarterly Publication of the Middle Atlantic Writers Association (1992), 7(1), 41-49

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See detailBehavioral Demasculinization of Female Quail Is Induced by Estrogens: Studies with the New Aromatase Inhibitor, R76713
Balthazart, Jacques ULg; De Clerck, A.; Foidart, Agnès ULg

in Hormones & Behavior (1992), 26(2), 179-203

The injection before Day 12 of incubation of estradiol benzoate (EB) into Japanese quail eggs produces a complete behavioral demasculinization of adult males that will hatch from these eggs. These males ... [more ▼]

The injection before Day 12 of incubation of estradiol benzoate (EB) into Japanese quail eggs produces a complete behavioral demasculinization of adult males that will hatch from these eggs. These males never show copulatory behavior even after administration of high levels of exogenous testosterone (T). It is usually assumed that such a demasculinization normally takes place in female embryos under the influence of endogenous estrogens but few experimental data are available to confirm the validity of this model. A series of four experiments was performed during which R76713, a triazole derivative that specifically inhibits aromatase (estrogen synthetase) activity, was injected into quail eggs at different stages of incubation to prevent the production of endogenous estrogens. The consequences of these embryonic treatments on the T-activated sexual behavior in adults were then quantified. When injected before Day 12 of incubation, R76713 completely blocked the behavioral demasculinization of females without affecting the behavior of the males. After a treatment with T, almost all R76713-treated females showed as adults a masculine copulatory behavior that was undistinguishable from the behavior of intact males. This effect was fully reversed by the injection in egg of EB demonstrating that the effects of R76713 were specifically due to the suppression of endogenous estrogens. Injection of R76713 during the late phase of the incubation (Day 12 or Day 15) only maintained weak copulatory behavior in females which confirmed that the behavioral demasculinization in quail takes place mainly though not exclusively during the early stages of ontogeny. In a last experiment, we combined an early R76713 treatment with an injection of EB either on Day 9 or on Day 14 of incubation. This showed that the sensitivity to differentiating effects of estrogens varies with age in a sexually differentiated manner. The EB injection on Day 9 demasculinized both male and female embryos. If this injection was delayed until Day 14, it was no longer effective in males but still caused a partial demasculinization of females. This demonstrates that even if females are not yet behaviorally demasculinized on Day 9 of incubation (suppression of aromatase activity at that age will maintain the behavior), their sensitivity to estrogens is already different from that of males. [less ▲]

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See detailVarietal Distribution Of The Trypsin-Inhibitor Activity In Peas (Pisum-Sativum L)
Leterme, Pascal; Monmart, Thierry; Thewis, André ULg

in Animal Feed Science & Technology (1992), 37(3-4), 309-315

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See detailLes malformations arterio-veineuses congénitales des membres: à propos de 4 cas
Krawczykowski, D.; VAN DAMME, Hendrik ULg; TROTTEUR, Geneviève ULg et al

in Revue Médicale de Liège (1992), 47(6), 284-91

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See detailUnilateral Facial Pain as the First Symptom of Lung Cancer: Are There Diagnostic Clues?
Schoenen, Jean ULg; Broux, R.; Moonen, G.

in Cephalalgia : An International Journal of Headache (1992), 12(3), 178-9

We describe three patients with unilateral facial pain due to non-metastatic lung cancer and review 11 published cases. Pain, most frequently located on the right side and around the ear, as well as ... [more ▼]

We describe three patients with unilateral facial pain due to non-metastatic lung cancer and review 11 published cases. Pain, most frequently located on the right side and around the ear, as well as digital clubbing can be clues to an early diagnosis. Compression of the vagus nerve by the tumour or by mediastinal adenopathy is most likely responsible for the facial pain and could play a role in pulmonary osteoarthropathy. [less ▲]

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See detailINFLUENCE OF THE DAILY DISTRIBUTION OF LIGHT ON REPRODUCTION IN THE BARBEL, BARBUS-BARBUS (L)
Poncin, Pascal ULg

in Journal of Fish Biology (1992), 41(6), 993-997

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See detailNucleotide and Derived Amino Acid Sequence of the Subtilisin from the Antarctic Psychrotroph Bacillus Ta39
Narinx, E.; Davail, S.; Feller, Georges ULg et al

in Biochimica et Biophysica Acta (1992), 1131(1), 111-3

The nucleotide sequence of the subtilisin-encoding gene from the antarctic psychrotroph Bacillus TA39 was determined. The primary structure of the subtilisin precursor is composed of 420 amino acids ... [more ▼]

The nucleotide sequence of the subtilisin-encoding gene from the antarctic psychrotroph Bacillus TA39 was determined. The primary structure of the subtilisin precursor is composed of 420 amino acids giving rise to a mature enzyme of 309 amino acids. Asp-145, His-185 and Ser-361 are the proposed catalytic residues of the active site. [less ▲]

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See detailEffect of Spinal Cord Stimulation on Regional Myocardial Perfusion Assessed by Positron Emission Tomography
de Landsheere, Christian ULg; Mannheimer, C.; Habets, A. et al

in American Journal of Cardiology (1992), 69(14), 1143-9

Spinal cord stimulation (SCS) can relieve symptoms in patients with severe angina pectoris refractory to conventional medical or surgical therapy. This symptomatic improvement may result from decreased ... [more ▼]

Spinal cord stimulation (SCS) can relieve symptoms in patients with severe angina pectoris refractory to conventional medical or surgical therapy. This symptomatic improvement may result from decreased myocardial ischemia. To test this hypothesis, positron emission tomography (PET) and potassium-38 as a flow tracer were used in 8 patients for the quantitative evaluation of regional myocardial perfusion at rest and after exercise, before and during SCS. Potassium uptake was evaluated as myocardial clearance (flow times net extraction) in ml/min/100 g. Tomographic segments were categorized as nonaffected and affected on the basis of the absence or presence of arterial stenosis on coronary angiography and on the basis of thallium scintigraphic data. In nonaffected segments, before SCS, regional myocardial clearance significantly increased from rest (28 +/- 4) to exercise (47 +/- 13 clearance units; p less than 0.004). A similar increase occurred after SCS. In affected segments, before SCS, regional myocardial clearance barely increased (p = 0.065) from rest (26 +/- 6) to exercise (33 less than or equal to 12). In comparison, after SCS, the resting regional myocardial clearance was slightly elevated (29 +/- 8) reflecting an increased double product, but did not increase (p = 0.192) with exercise (34 +/- 12). However, the magnitude and duration of ST-segment depression decreased during treatment with SCS. Anginal pain occurred in all patients during control exercise, but was attenuated in all but one with SCS. These results indicate that SCS improves exercise-induced angina and electrocardiographic signs of ischemia but this influence does not appear to be mediated by changes in regional myocardial perfusion. [less ▲]

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See detailHD 35155: the First Eclipsing Binary S Star (P=642 Days)
Jorissen, A.; Mayor, M.; Manfroid, Jean ULg et al

in Information Bulletin on Variable Stars (1992), 3730

Not Available

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See detailThe climate induced variation of the continental biosphere: A model simulation of the last glacial maximum
Friedlingstein, P.; Delire, C.; Müler, J. F. et al

in Geophysical Research Letters (1992), 19

A simplified three-dimensional global climate model was used to simulate the surface temperature and precipitation distributions for the Last Glacial Maximum (LGM), 18000 years ago. These fields were ... [more ▼]

A simplified three-dimensional global climate model was used to simulate the surface temperature and precipitation distributions for the Last Glacial Maximum (LGM), 18000 years ago. These fields were applied to a bioclimatic scheme which parameterizes the distribution of eight vegetation types as a function of biotemperature and annual precipitation. The model predicts a decrease, for LGM compared to present, in forested area balanced by an increase in desert and tundra extent, in agreement with a reconstruction of the distribution of vegetation based on paleodata. However, the estimated biospheric carbon content (phytomass and soil carbon) at LGM is less reduced than in the reconstructed one. Possible reasons for this discrepancy are discussed. [less ▲]

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See detailSystematic color transformation effects in Stromgren photometry
Manfroid, Jean ULg; Sterken, C.

in Astronomy and Astrophysics (1992), 258

A major cause of errors in photometry is to be attributed to the color transformation. A thorough analysis of numerous observing runs carried out in the Stromgren system shows how reliable are the ... [more ▼]

A major cause of errors in photometry is to be attributed to the color transformation. A thorough analysis of numerous observing runs carried out in the Stromgren system shows how reliable are the transformations in the different indices. Conclusions are drawn about the reduction methods, the validity of homogenization procedures, and the choice of the standard stars which define the system. [less ▲]

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See detailThe intervalling effect bias in beta: a note
Corhay, Albert ULg

in Journal of Banking & Finance (1992), 16(1), 61-73

Based on a comprehensive sample of domestic securities traded on the Brussels Stock Exchange, this paper points out the intervalling effect in the estimated betas and examines the speed of convergence of ... [more ▼]

Based on a comprehensive sample of domestic securities traded on the Brussels Stock Exchange, this paper points out the intervalling effect in the estimated betas and examines the speed of convergence of these. The results reveal that the estimated betas seem to converge to their asymptotic values and that their value depends on what day the differencing interval starts. It also appears that the magnitude of the intervalling effect is inversely related to the market value of the firms. [less ▲]

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See detailCalcitonin Metabolism in Senile (Type II) Osteoporosis
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Bruwier, Maurice ULg et al

in Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis & the National Osteoporosis Foundation of the USA (1992), 2

The exact role of calcitonin (CT) in the pathogenesis of senile (Type II) osteoporosis remains unknown. Whole plasma calcitonin (iCT) and extracted monomeric calcitonin (eCT) basal levels, metabolic ... [more ▼]

The exact role of calcitonin (CT) in the pathogenesis of senile (Type II) osteoporosis remains unknown. Whole plasma calcitonin (iCT) and extracted monomeric calcitonin (eCT) basal levels, metabolic clearance rate (MCR) and production rate (PR) of iCT and eCT were measured in 41 postmenopausal women, including 14 hip fractures (OP II) and 27 healthy controls. No significant difference appeared for basal iCT levels between OP II (mean +/- SEM: 41.9 +/- 3.4 pg/ml) and controls (mean +/- SEM: 46.2 +/- 5 pg/ml). eCT basal levels were similar in OP II (mean +/- SEM: 5.42 +/- 0.5 pg/ml) and in controls (mean +/- SEM: 7.3 +/- 0.7 pg/ml). MCR were similar in the two groups. iCT PR were similar in OP II (mean +/- SEM: 17.2 +/- 1.5 micrograms/24 h) and controls (mean +/- SEM: 18.6 +/- 1.1 micrograms/24 h). No difference appeared between eCT PR in OP II (mean +/- SEM: 2.3 +/- 0.2 micrograms/24 h) and controls (mean +/- SEM: 3.2 +/- 0.3 pg/ml). From these data, no evidence appears that calcitonin might be one of the determinant factors in the pathogenesis of senile osteoporosis. [less ▲]

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See detailOnce-a-day administration of amikacin in neonates: assessment of nephrotoxicity and ototoxicity
Battisti, Oreste ULg; Langhendries, J. P.; Bertrand, J. M. et al

in Developmental Pharmacology and Therapeutics (1992), 20

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See detailThe computation of prismatic structures, applied to naval architecture
Rigo, Philippe ULg

in Marine Structures (1992)

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See detailCytogenetic Changes in Hepatocarcinomas from Rats Treated with Chronic Exposure to Diethylnitrosamine
Herens, Christian ULg; Alvarez Gonzalez, Maria-Luz ULg; Barbason, Hervé ULg

in Cancer Genetics & Cytogenetics (1992), 60(1), 45-52

Cytogenetic analysis of rat hepatocarcinomas obtained after diethylnitrosamine (DEN) exposure showed a wide variety of numerical and structural chromosomal changes: 53 of 86 hepatocellular carcinomas ... [more ▼]

Cytogenetic analysis of rat hepatocarcinomas obtained after diethylnitrosamine (DEN) exposure showed a wide variety of numerical and structural chromosomal changes: 53 of 86 hepatocellular carcinomas showed at least one recurrent chromosomal aberration. Some of these recurrent changes occurred in several tumors. Chromosomes 1, 3, 11, and 12 were abnormal in more than 30% of the carcinomas; chromosomes 2, 4, 5, and 10 were abnormal in 10%. Moreover, chromosomes 1 and 10 were generally lost or deleted and chromosome 3, 4, and 11 were very often gained. The most frequent anomaly was loss of chromosome 1 which was observed in 35% of the tetraploid cell populations. The occurrence in several tumors of recurrent chromosomal rearrangements as well as various repeated aneuploidies strongly suggests that these anomalies are implicated in the process of rat hepatocarcinogenesis induced by DEN treatment. [less ▲]

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See detailCardiovascular Response to Acute Hypoxia in Double-Muscled Calves
Amory, Hélène ULg; Rollin, Frédéric ULg; Desmecht, Daniel ULg et al

in Research in Veterinary Science (1992), 52(3), 316-24

Hypoxic-induced pulmonary hypertension is known to be intensive in the bovine species and sometimes leads to pathological cardiac repercussions. On the other hand, doubled-muscled cattle are predisposed ... [more ▼]

Hypoxic-induced pulmonary hypertension is known to be intensive in the bovine species and sometimes leads to pathological cardiac repercussions. On the other hand, doubled-muscled cattle are predisposed to develop hypoxaemia during exercise and with respiratory diseases. Therefore the purpose of this study was to investigate the cardiovascular response to acute hypoxia in double-muscled calves compared with calves of standard conformation. Pulmonary arterial pressure, electrocardiogram and blood temperature were simultaneously recorded, arterial blood was sampled for blood gas analysis and cardiac output was determined in six Friesian calves and six double-muscled calves of the Belgian White and Blue breed(BWB) when breathing air (fractional inspiratory oxygen concentration [FIO2]: 21 per cent) and when breathing a hypoxic gas mixture (FIO2: 10 per cent). All the absolute values of the measured parameters were significantly (P less than or equal to 0.001) different between the two breeds, except heart rate and arterial blood gas values. The pattern of hypoxic-induced decrease in arterial PO2 was similar in the two breeds of calves, suggesting that the pulmonary exchange capacities during hypoxia are no less efficient in double-muscled calves than in calves of standard conformation. Similarly, the percentage of variation of the mean pulmonary arterial pressure from its normoxic to its hypoxic value was the same in the two breeds of calves, suggesting that double-muscled calves are not predisposed to develop a more precocious or more intense pulmonary hypertension for a given level of hypoxaemia. The significantly smaller normoxic and hypoxic cardiac index and stroke index found in BWB compared with Friesian calves was interpreted as a less efficient cardiac function in double-muscled subjects. [less ▲]

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See detailIdentification and Characterization of Glycoprotein Gp1 of Bovine Herpesvirus Type 4
Dubuisson, J.; Pastoret, Paul-Pierre ULg; Thiry, Etienne ULg

in Journal of General Virology (The) (1992), 73((Pt 5)), 1293-6

Three major bovine herpesvirus type 4 (BHV-4) glycoproteins have been described previously. By using monoclonal antibodies produced against BHV-4 envelope proteins from which the three major antigens had ... [more ▼]

Three major bovine herpesvirus type 4 (BHV-4) glycoproteins have been described previously. By using monoclonal antibodies produced against BHV-4 envelope proteins from which the three major antigens had been removed by immunoaffinity, a fourth glycoprotein was identified. This protein (gp1) has a high Mr (greater than 300K), is detected about 8 h post-inoculation of infected cells and is strictly expressed as a gamma protein. Moreover, gp1 was identified by a polyclonal antiserum from an infected animal, indicating that this glycoprotein is an antigen recognized by the immune system of infected animals. [less ▲]

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See detailRoll Motion of a Floating Storm surge Barrier
Rigo, Philippe ULg

in Journal of Hydroscience and Hydraulic Engineering (1992)

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See detailContrast behavior between microadenoma and normal pituitary gland after gadolinium injection as a function of time at 1.5 T.
Stadnik, T.; Stevenaert, Achille ULg; Beckers, Albert ULg et al

in Neuroradiology (1992), 34(3), 184-9

The behavior of contrast enhancement between a microadenoma and the normal pituitary gland after gadolinium injection was evaluated in 12 operatively confirmed cases using a repetitive sequence of four ... [more ▼]

The behavior of contrast enhancement between a microadenoma and the normal pituitary gland after gadolinium injection was evaluated in 12 operatively confirmed cases using a repetitive sequence of four coronal T1-weighted spin echo series (T1 SE) (continuous acquisition, TR = 400 ms), followed by conventional coronal T1 SE (TR = 600 ms) and a three-dimensional fast low-angle shot sequence. The first and second acquisitions were useful with respect to delayed scans only in 3 cases (25%). Nevertheless, in these cases confident diagnosis could also be made on pre-contrast studies, which diminishes the real advantage of this finding. For a 1.5 T MRI unit we advocate starting with coronal T1 SE 30 s after a rapid injection of gadolinium. [less ▲]

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See detailBrain oxygen transport related to levels of fetal haemoglobin in stable preterm infants.
RAMAEKERS, Vincent ULg; Daniels, H.; Casaer, P.

in Journal of developmental physiology (1992), 17(5), 209-13

The relative amount of regional cerebral oxygen transport was compared between different preterm infants by performing measurements of cerebral blood flow velocity, mean arterial blood pressure, whole ... [more ▼]

The relative amount of regional cerebral oxygen transport was compared between different preterm infants by performing measurements of cerebral blood flow velocity, mean arterial blood pressure, whole blood viscosity and haemoglobin content for each individual. In addition the percentage of fetal haemoglobin was determined. On 25 occasions measurements of fetal haemoglobin and cerebral oxygen transport have been performed prior to and following a blood transfusion with adult red blood cells. Comparison of the data for cerebral oxygen transport suggests that the actual amount of cerebral oxygen transport is lowest at fetal haemoglobin levels below 30% and will increase progressively as soon as the percentage of fetal haemoglobin rises about 30%. Thus, at increasing fetal haemoglobin levels, cerebral haemodynamic mechanisms in the human neonate cause elevations of regional cerebral blood flow and oxygen transport. The found increase of cerebral blood flow and oxygen transport at high fetal haemoglobin levels will minimize the impeded dissociation and delivery of oxygen to brain tissues. [less ▲]

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See detailEffect of Repeated Intradermal Injections of Bovine Herpesvirus Type 1 Antigen on Seronegative Cattle
Thiry, Etienne ULg; Wellemans, G.; Limbourg, B. et al

in Veterinary Record : Journal of the British Veterinary Association (1992), 130(17), 372-5

Forty-three cattle seronegative to bovine herpesvirus-1 (BHV-1) were given from one to five intradermal injections of BHV-1 inactivated antigen at four-week intervals. This delayed hypersensitivity test ... [more ▼]

Forty-three cattle seronegative to bovine herpesvirus-1 (BHV-1) were given from one to five intradermal injections of BHV-1 inactivated antigen at four-week intervals. This delayed hypersensitivity test was assessed by the increase in skin thickness. The activity of the antigen was assessed in five animals which had a previous natural BHV-1 infection with clinical signs and seroconversion. Anti-BHV-1 antibodies were detected by seroneutralisation and an enzyme-linked immunoassay. Only one animal showed a significant but slight increase in skin thickness after the first test, but it was negative after a second test. The animals remained seronegative after the first test. Seroconversion was identified in 11 of the 43 animals (25 per cent) submitted to repeated delayed hypersensitivity tests. Five of 37 animals seroconverted after only two tests. The serological response was transient in seven of 11 seroconverted calves. Repeated hypersensitivity tests were therefore able to induce a serological response in seronegative calves but the response was weak and often transient. The test must therefore be applied cautiously to seronegative animals. [less ▲]

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