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See detailUne banque de questions au service de l'évaluation formative dans l'enseignement technique du deuxième degré
Denis, Brigitte ULg; Bosmans, Catherine ULg; Jans, Véronique

in Informations pédagogiques (1996), (22), 23-33

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See detailShedding of the 67-kD laminin receptor by human cancer cells.
Karpatova, M.; Tagliabue, E.; Castronovo, Vincenzo ULg et al

in Journal of Cellular Biochemistry (1996), 60(2), 226-34

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix ... [more ▼]

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix has been recently suggested by electron microscopy studies, there is to date no evidence of shedding of the 67LR from cells. Using two monoclonal antibodies directed against the 67LR, we developed a double-determinant radioimmunoassay that demonstrates that the 67LR is released from cancer cells into the culture medium. The shed molecule exhibited the same apparent molecular weight as that of the membrane-associated 67LR, suggesting that no proteolytic cleavage is involved in the process. Furthermore, we demonstrate that the 67LR is not anchored to the membrane through a glycolsyl-phosphatidylinositol bridge. However, the observation that lactose increased the release of 67LR suggests that a lectin-type interaction is involved in the cell membrane association of this laminin binding protein and the cell surface. Interestingly, the released 67LR recovered after HPLC gel filtration was found free as well as associated to high molecular weight complexes. The free 67LR retained its ability to bind to the cell surface. Our study is the first demonstration that the 67LR is effectively shed by cancer cells. The released free 67LR could play an important role in modulating interactions between cancer cells and laminin during tumor invasion and metastasis. [less ▲]

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See detailEstimations du taux de la plus-value en Belgique (1948-1994): méthode et résultats
Geerkens Provin, Eric ULg

in Contradictions (1996), (78-79), 85-98

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See detailTabac et maladie parodontale
Geerts, Sabine ULg

in Actualités Dentaires de l'Université de Liège (1996), 19

Le tabac est un facteur aggravant la parodontite. Beaucoup d'études cliniques ont été menées et ont souvent montré des résultats contradictoires. Cet article est une revue de littérature sur la relation ... [more ▼]

Le tabac est un facteur aggravant la parodontite. Beaucoup d'études cliniques ont été menées et ont souvent montré des résultats contradictoires. Cet article est une revue de littérature sur la relation entre le tabagisme et la parodontite. [less ▲]

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See detailPreliminary study of the Black Sea's plankton bloom
Grégoire, Marilaure ULg; Beckers, Jean-Marie ULg; Nihoul, Jacques ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1996), 65(1), 91-94

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See detailTreatment of osteoporosis: where are we and where are we going to
Reginster, Jean-Yves ULg

in Revista de Reumatologia (1996), 4

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See detailGastrin levels in serum and bronchoalveolar lavage fluid of patients with lung cancer: comparison with patients with chronic obstructive pulmonary disease.
Dowlati, A; Bury, Thierry ULg; CORHAY, Jean-Louis ULg et al

in Thorax (1996), 51(12), 1270-2

BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and ... [more ▼]

BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and serum of patients with lung cancer. Based on these preliminary data a study was conducted to evaluate the usefulness of gastrin measurements in the diagnosis and staging of lung cancer. METHODS: Thirty-five patients with lung cancer (26 non-small cell (NSCLC) and nine small cell (SCLC)) and 25 patients with chronic obstructive pulmonary disease underwent fibreoptic bronchoscopy and BAL. Gastrin levels were determined in both BAL fluid and the serum and compared with each other and with staging. RESULTS: No difference was found between the gastrin levels in the BAL fluid or serum of the study groups. There was no correlation with the stage in NSCLC and no correlation was found between the gastrin levels in the serum and the BAL fluid. A significant difference was seen in gastrin levels in BAL fluid between extensive and limited SCLC (p < 0.05). CONCLUSION: There is no evidence of clinical usefulness for gastrin measurements in lung cancer. [less ▲]

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See detailCosmological formation of low-mass objects
Haiman, Z.; Thoul, Anne ULg; Loeb, A.

in Astrophysical Journal (1996), 464(2), 523-538

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks ... [more ▼]

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks starting from the linear perturbative regime. The initial parameters correspond to density peaks of various widths and heights in a cold dark matter cosmology. We use a one-dimensional spherical Lagrangian hydrodynamics code to follow the dynamical, thermal, and nonequilibrium chemical evolution of the gas. The system includes a collisionless dark matter component and a baryonic component composed of the nine species H, H-, H+, He, He+, He++, H-2, H-2(+), and e(-). All relevant chemical reactions between these species and their cooling mechanisms are included in the calculations. We explore the dependence of the dynamical evolution of the gas on two parameters: the initial mass scale and the initial overdensity of the system. We follow the evolution of the density, temperature, and abundance profiles within the cloud, assuming two types of central boundary conditions for the collisionless component: in one the infalling dark matter virializes through a reflection from a hard sphere, while in the other it accretes onto a central sink. We find that in both cases, radiative cooling by H-2 affects the collapse dynamics of the gas only after it has already virialized and become part of the bound object. Therefore, radiative cooling is unlikely to have triggered the initial collapse of perturbations at redshifts z>10. Nevertheless, baryonic objects with masses well below the linear theory Jeans mass (less than or similar to 10(3) M.) form at high redshifts because of shell crossing by the dark matter. Such objects could be the progenitors of a primordial population of high-mass stars in the intergalactic medium. [less ▲]

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See detailPaget’s disease of bone : diagnosis and management
Hosking, D; Meunier, PJ; Ringe, JD et al

in British Medical Journal (1996), 312

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See detailInfection of cattle with Yersinia enterocolitica O:9 a cause of the false positive serological reactions in bovine brucellosis diagnostic tests.
Weynants, V.; Tibor, A.; Denoel, P. A. et al

in Veterinary Microbiology (1996), 48(1-2), 101-12

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of ... [more ▼]

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of brucellosis was reported in these animals and no Brucella abortus strains were isolated. After two years, no brucellosis outbreak was registered in all of the herds concerned. On this basis, all the serological reactions observed were classified as false positive. An ELISA using Yersinia Outer membrane Proteins (YOPs) as antigens was developed in order to discriminate between a Yersinia enterocolitica O:9 infection and a Brucella abortus infection. Antibodies against YOPs were detected in sera from Y. enterocolitica O:9 experimentally infected cattle (n = 4) but not in sera from B. abortus experimentally infected cattle (n = 4). In a field study, 66.7% of the 174 serum samples from cattle presenting false positive serological reactions showed anti-YOPs antibodies whereas only 10% of 454 sera, classified negative by the brucellosis screening tests, showed anti-YOPs antibodies. Our results suggest that infections with Y. enterocolitica O:9 may cause false positive reactions in brucellosis testing. [less ▲]

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See detailTransition probabilities for [Ni I] and [Ni II] lines
Quinet, Pascal ULg; Le Dourneuf, M

in Astronomy and Astrophysics. Supplement Series (1996), 119

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See detailDifférenciation génétique et morphologique du mulot, Apodemus sylvaticus, dans le bassin Méditerranéen occidental
Michaux, Johan ULg; Libois, Roland ULg; Fons, Roger

in Vie et Milieu (1996), 46(3-4), 193-203

Many questions are still unanswered about the biogeography and the origin of the wood mouse in the Mediterranean area, namely on the islands where some giant forms are described. In order to characterize ... [more ▼]

Many questions are still unanswered about the biogeography and the origin of the wood mouse in the Mediterranean area, namely on the islands where some giant forms are described. In order to characterize the genetic structure of these insular populations and their level of morphological differentiation, 232 animals originating from 30 localities situated on several western Mediterranean islands and on the continent, either along the sea coast or more inland, were trapped. Their skulls were measured and their mtDNA purified and analysed by RFLP techniques. The wood mice living on small islands are generally bigger than their relatives living on the continent whereas the size of those living on larger islands is quite the same. This kind of insular gigantism ought to be more an adaptive response to peculiar insular environmental conditions (particularly a lower predation pressure) than a consequence of a founder effect. The mtDNA of the wood mice from north-eastern Spain belongs to the previously identified northwestern group (Michaux et al., 1996). Consequently, the Pyrenees are not a biogeographic barrier to the wood mouse. The Sicilian mice, which are genetically different from all the other west European or north-African animals, are morphologically similar to the Sardinian and Italian ones. [less ▲]

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See detailParcours d’un chartiste : Robert-Henri Bautier et le recueil de ses articles
Marchandisse, Alain ULg

in Moyen Age (Le) (1996), 102

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See detailProduction of anti-PMSG antibodies and its relation to the productivity of rabbit does
Lebas, F.; Theau-Clement, M.; Remy, Benoît ULg et al

in World Rabbit Science (1996), 4(2), 57-62

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See detailThe attenuated V60 strain of channel catfish virus possesses a deletion in ORF50 coding for a potentially secreted glycoprotein
Vanderheijden, NATHALIE; Alard, PHILIPPE; Lecomte, CORINE et al

in Virology (1996), 218(2), 422-6

A wild-type strain of channel catfish virus was compared at the genomic level with the attenuated strain V60. In addition to several minor differences, restriction mapping revealed one major deletion ... [more ▼]

A wild-type strain of channel catfish virus was compared at the genomic level with the attenuated strain V60. In addition to several minor differences, restriction mapping revealed one major deletion (approximately 1200 bp) in ORF50 of the V60 strain. Cloning and sequencing of part of this ORF confirmed the presence of a 1164-bp deletion. It should result in a protein of 282 amino acids instead of 670. The predicted truncated protein lacks most of a threonine-rich, highly repetitive region in its central part. Since the protein encoded by ORF50 possesses a hydrophobic N-terminal leader sequence and no membrane anchor sequence, we suggest that it could be a secreted glycoprotein. This protein might be N-glycosylated (35 potential sites) and, given the repetitive arrangement of its residues (mainly threonines), also heavily O-glycosylated like the mucin-type glycoproteins. The deletion observed in ORF50 of the V60 strain implies the loss of 24 potential N-glycosylation sites and should considerably reduce the extent of O-glycosylation. [less ▲]

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See detailLes populations de rats noirs insulaires de l'ouest de l'Europe. Essai préliminaire de caractérisation génétique (caryotype et ADN mitochondrial)
Libois, Roland ULg; Torrico, Jorge; Ramalhinho, Maria Graça et al

in Vie et Milieu (1996), 46(3-4), 213-218

The colonisation of Europe by the black rat (Rattus rattus) dates back only to the Roman times. This rodent is now widespread all over the continent as well as on many islands where it was introduced by ... [more ▼]

The colonisation of Europe by the black rat (Rattus rattus) dates back only to the Roman times. This rodent is now widespread all over the continent as well as on many islands where it was introduced by man. In some instances, insular populations are morphologically differentiated by their greater size. In order to study the possible origin of these insular populations, rats were caught on many Mediterranean (Sicily, Sardinia, Lavezzi, Corsica, Elba, Porquerolles) and Atlantic islands (Ré, Oléron, Azores) and compared to animals from continental Europe (Spain), and Africa (Tunisia, Benin). Their karyotype was determined and their mtDNA restriction patterns studied using the HAE III and RSA I endonucleases and a polyacrylamide gel electrophoresis. These patterns appear very similar to each other though one of them is specific to the African animals, probably indicating that Europe and Africa were colonised by different strains. [less ▲]

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See detailArthrite septique du boulet : corrélation entre imagerie et examen anatomo-pathologique
Busoni, Valeria ULg; Rossi, Giacomo; Denoix, Jean-Marie

in Pratique Vétérinaire Equine (1996), 28

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See detailPurification of soybean lipoxygenase isoenzyme-1 and characterization of its inhibition by 13-hydroperoxides.
Fauconnier, Marie-Laure ULg; Marlier, M.

in Grasas y Aceites (1996), 47(4), 242-246

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See detailSanglante campagne en Tchétchénie
Bachkatov, Nina ULg

in Monde Diplomatique (Le) : Journal des Cercles Diplomatiques et des Grandes Organisations Internationales (1996)

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See detailThe Ahrensburgian site at Zonhoven-Molenheide
Vermeersch, Pierre M.; Peleman, Chris; Rots, Veerle ULg et al

in Notae Praehistoricae (1996), 16

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See detailLa place actuelle de l'immunoanalyse en Toxicologie Clinique
Charlier, Corinne ULg; Plomteux, Guy ULg

in Immuno-Analyse & Biologie Spécialisée [=IBS] (1996), 11

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See detailAnalyse de "La Mort" de Maurice Carême
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1996), 29

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See detailEvaluation du débit sanguin au niveau du quadriceps électrostimulé et contracté volontairement
Vanderthommen, Marc ULg; BAUVIR, Philippe ULg; Depresseux, J.C. et al

in Annales de Kinésithérapie (1996), 23(1), 20-23

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See detailA site with foliicolous lichens in Belgium
van den Boom, Pieter; Sérusiaux, Emmanuël ULg

in Belgian Journal of Botany (1996), 129

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See detailMort mitotique ou mort apoptotique par irradiation : Même combat ?
Coucke, Philippe ULg; ZOUHAIR

in Médecine et Hygiène (1996), 54(2121), 1241-1245

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement ... [more ▼]

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement oncologique. Les radiations ionisantes sont capables d'induire une mort mitotique et une mort apoptotique. Nous définissons les caractéristiques radiobiologiques de chaque type de mort cellulaire et situons l'importance de l'apoptose pour la réponse tumorale aux radiations ionisantes. La modulation de ce «suicide cellulaire» devrait permettre une amélioration de l'index thérapeutique mais ceci implique une connaissance approfondie des mécanismes qui règlent l'apoptose [less ▲]

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See detailAn improved preparation method of benzyl and thenyl triphenylphosphonium salt
Zhang, Jian-Xin; Dubois, Philippe ULg; Jérôme, Robert ULg

in Synthetic Communications (1996), 26(16), 3091-3095

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine ... [more ▼]

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine can also be converted within high yields to phosphonium salts by removing the formed water by azeotropic distillation. Solvent (methylene chloride, chloroform and acetonitrile) and temperature have been chosen in close relation to the alcohol reactivity. Purification is straightforward and yields are relatively high. [less ▲]

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See detailCellular Pathways Involved In The Ex Vivo Expression Of Bovine Leukemia Virus
Kerkhofs, P.; Adam, E.; Droogmans, L. et al

in Journal of Virology (1996), 70(4),

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See detailRecommendations for registration of drugs used in the treatment of osteoarthritis
Dougados, M; Devogelaer, JP; Annefeldt, M et al

in Annals of the Rheumatic Diseases (1996), 55

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See detailTwo rare European Ephemerum species (Bryophita): E. cohaerens rediscovered near Strasbourg (France) and E. stellatum new to Belgium
Vanderpoorten, Alain ULg; Stieperaere, H.; Klein, J.-P.

in Belgian Journal of Botany (1996), 129

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See detailIBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15
Charlier, Carole ULg; Farnir, Frédéric ULg; Berzi, P. et al

in Genome Research (1996), 6

Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single ... [more ▼]

Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single acknowledged carrier founder individual. Between seven and nine generations separated the founder from its 12 affected descendents. The 12 affected offspring were genotyped for a battery of 213 microsatellites spanning the 29 bovine autosomes. The resulting genotypes were analyzed using a maximum likelihood approach searching for shared homozygous haplotypes among affected individuals. Three candidate regions for the syndactyly locus emerged from this initial screening. syndactyly was shown to map to one of these candidate regions on chromosome 15 by genotyping 29 additional individuals linking founder and affected offspring and performing a conventional linkage analysis with the LINKAGE programs. This study illustrates the potential of identity-by-descent mapping in livestock populations. [less ▲]

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See detailElectrical microenvironment influence on the hydrolytic activity of free and immobilised Yarrowia lipolytica lipase
Paquot, Michel ULg; Deleu, Magali ULg; Beaufils, C. et al

in Biotechnology Letters (1996), 18(1), 73-78

The role of electrical properties of interfaces upon the activity of free and immobilised Yarrowia lipolytica lipase has been investigated. Sodium taurocholate and Sedipur 400, an anionic polyacrylamide ... [more ▼]

The role of electrical properties of interfaces upon the activity of free and immobilised Yarrowia lipolytica lipase has been investigated. Sodium taurocholate and Sedipur 400, an anionic polyacrylamide, enhance the negative character of the fatty droplets of substrate and tend to improve the lipolytic activity while the cationic polyacrylamide (Sedipur 900) has opposite effects. Ca+ which reduces the fatty droplets charge as Sedipur 900, is however a good activator of the enzyme. The role of electrical properties on the optimum pH of the immobilised enzyme is clearer. Immobilisation of the lipase on a positively charged support shifts its optimum pH to acidic pH by repulsion towards H+ ions around the support. [less ▲]

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See detailHyperfine structure of infrared Al II lines
Palmeri, P.; Biémont, Emile ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailAssessment of the cell-mediated immunity in cattle infection after bovine herpesvirus 4 infection, using an in vitro antigen-specific interferon-gamma assay.
Godfroid, J.; Czaplicki, G.; Kerkhofs, P. et al

in Veterinary Microbiology (1996), 53(1-2), 133-41

The cell-mediated immunity (CMI) following bovine herpesvirus 4 (BHV4) infection has been poorly investigated in cattle. The in vivo response measured by a delayed type of hypersensitivity (DTH) assay has ... [more ▼]

The cell-mediated immunity (CMI) following bovine herpesvirus 4 (BHV4) infection has been poorly investigated in cattle. The in vivo response measured by a delayed type of hypersensitivity (DTH) assay has been reported to be positive in only few animals showing serological evidences of BHV4 infection. We have investigated the CMI following BHV4 infection by an in vitro antigen-specific interferon gamma (IFN-gamma) release assay, as an indicator of an actively acquired immunity to BHV4. Our preliminary results using a partially purified antigen suggest that there was a measurable CMI in 75 out of 168 animals (44.4%) originating from a farm with a clinical history and serological evidences (76.3% seropositivity) of BHV4 infection. If the results of serological tests and BHV4 IFN-gamma test are interpreted in parallel, 81.5% of the animals are classified positive, demonstrating the complementarity of these tests. The specificity of the BHV4 IFN-gamma test was supported by the absence of a measurable CMI in 41 animals originating from a farm with no clinical history or serological evidence of BHV4 infection. In an allied study, we developed a bovine herpesvirus 1 (BHV1) IFN-gamma test. This allowed us to measure the antigen specific IFN-gamma release after stimulation with a mixture of BHV1 and BHV4 antigens. Animals that were classified negative by the BHV4 IFN-gamma test and by the BHV1 IFN-gamma test, were classified negative after stimulation with a mixture of both antigens. Animals that were classified positive by the BHV4 IFN-gamma test or the BHV1 IFN-gamma test, were classified positive after stimulation with a mixture of both antigens. Taken together these results suggest that the in vitro assessment of the CMI after BHV4 infection should be further investigated as a specific and valuable alternative to the DTH assay. [less ▲]

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See detailAge and correlation of the Barreinrinha Formation (Curua Group, Amazon Basin) : new evidence from the Miospore biostratigraphy
Loboziak, S.; Melo, J.H.G.; Rodriguez, R. et al

in Anais da Academia Brasileira de Ciencias (1996), 68(2), 207-212

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See detailL'immaginario lunare
Curreri, Luciano ULg

in La Battana (1996), 120

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See detailThe Appearance of CH3+ Ions from Methyl Halides by resonant photoionization. A translational energy surprisal analysis. Part I. CH3F.
Momigny, J.; Locht, Robert ULg

in Chemical Physics (1996), 206

A surprisal analysis has been applied to the translational energy distribution (TED) of CH3++F from CH3F giving rise to a new and deeper insight into the dissociation dynamics involved in the process. For ... [more ▼]

A surprisal analysis has been applied to the translational energy distribution (TED) of CH3++F from CH3F giving rise to a new and deeper insight into the dissociation dynamics involved in the process. For both the 16.5 eV and 21.22 eV photon energies used, the direct population at different energy levels of the B2E state of CH3F+ which is radiationlessly coupled to the repulsive CH3F+(A2A1) state, gives rise to wide and negatively surprised total TEDs. At both energies they have to be ascribed to severe limitations in the vibrational excitation of CH3+. Additionally, in the case of 21.22 eV photons, a non-statistical expression has to be used to account for the density of translational states. At both photon energies, the population of the CH3F+ electronic states through autoionization of Rydberg states accounts for (i) the concurrent appearance of TEDs governed by a pure RRKM behavour and (ii) the positively surprised TEDs where the angular momentum conservation plays an important role. At 16.85 eV photon energy the distributions are assigned to CH3F+ (X2E)->CH3+ (X1A'1)+F. At 21.22 eV photon energy, doubly excited electronic states of CH3F+ are assumed to take part and they are correlated with CH3+ (3A")+F channel. [less ▲]

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See detailLe cheval de trait ardennais convient-il pour l'attelage sportif
Crigel, MH; Art, Tatiana ULg; Votion, Dominique ULg et al

in Pratique Vétérinaire Equine (1996), 28

The Ardennais draught horse (DH) is more and more used for harnessing competitions. The aim of this study was to improve our knowledge of its cardiorespiratory peculiarities, both at rest and during ... [more ▼]

The Ardennais draught horse (DH) is more and more used for harnessing competitions. The aim of this study was to improve our knowledge of its cardiorespiratory peculiarities, both at rest and during exercise. At rest, arterial blood gas analysis, venous blood analysis, a test of mechanics of breathing and an endoscopy of the upper airways were performed. Experiments during exercise were performed on a treadmill. The intensity of the standardised test was sufficient to overshoot the OBLA threshold. The test was of increasing intensity and lasted 22 min. The cardiorespiratory parameters were measured during the last 5 min. Expired volume minute (VE), VT and f were measured. Respiratory O2 and CO2 fraction were measured with a mass spectrometer. Oxygen uptake (VOA, CO2 output (VCO2) and VE/VO2 were calculated. Heart rate (HR) was continuously measured.The results were compared to data recorded in standarbred horses (SH) during a treadmill exercise test leading to a similar lactaci¬demia (LA) and peak HR.The DH have a significantly lower V02 than the SH while running at an exercise intensity inducing the same HR and LA modifications. The lower aerobic capacity of DH was at least partly correlated with their higher cost of breathing and lower blood gas transport capacity.Moreover, other measurements have been performed infield conditions, during 4 draft competitions, i.e. speed, maniability, power and endurance. Venous blood analyses before and after the competition, heart rate and body temperature measurements were performed. The results of this second set of measurements confirm the results obtained in the laboratory and allow assessing that these kinds of competition do not induce dramatic physiological modifications and therefore respect the welfare and limits of these horses. [less ▲]

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See detailAuguste à Eleusis. Un aspect méconnu de l'idéologiqe augustéenne
Rochette, Bruno ULg

in Cahiers de Clio (1996), 127(automne), 3-14

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See detailNonspecific airway responsiveness of COPD horses : effects of environmental control
Vandenput, Sandrina ULg; Votion, Dominique ULg; Anciaux, N. et al

in Pflügers Archiv : European Journal of Physiology (1996), 431(6), 324

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See detailEnhancement of nuclear receptor transcriptional signalling.
Renkawitz, Rainer; Kaltschmidt, Christian; Leers, Joerg et al

in Journal of Steroid Biochemistry & Molecular Biology (1996), 56(1-6 Spec No), 39-45

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which ... [more ▼]

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which in most cases achieve the observed regulatory strength in synergy with other factors. Here we describe the functional interaction of the glucocorticoid receptor (GR) with liver-specific transcription factors, the functional synergy of GR with the thyroid hormone receptor (TR), the synergizing sub-domains of the TR, and finally the direct interaction of the GR with other proteins. [less ▲]

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See detailDetection And Identification Of Sweet Potato Viruses By The Polymerase Chain Reaction
Colinet, D.; Lepoivre, Philippe ULg; Xia, Fz. et al

in Agro Food Industry Hi-Tech (1996), 7(2),

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See detailRevisiting the evaluation of the performance of fluid-filled catheters
GERARD, P; POCHET, T; LAMBERMONT, Bernard ULg et al

in Medical & Biological Engineering & Computing (1996), 34

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See detailThe Use Of N-15-Labeled Dietary Proteins For Determining True Ileal Amino Acid Digestibilities Is Limited By Their Rapid Recycling In The Endogenous Secretions Of Pigs
Leterme, Pascal; Thewis, André ULg; Francois, Etienne et al

in Journal of Nutrition (1996), 126(9), 2188-2198

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary ... [more ▼]

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary N excretion pattern at the ileum subsequent to the ingestion of a single 15N-labeled meal. In a second experiment, we compared ileal endogenous AA outputs and true AA digestibility estimates obtained in pigs ingesting 15N-labeled dietary proteins in a single meal vs. intravenous infusion of 15N-leucine for 10 d during the ingestion of a pea-based diet and a protein-free starch diet. The proportion of endogenous N found in the ¡leal digesta differed when the label was delivered orally (50%) vs. intravenously (72%) and changed with time. As a consequence, the true ileal AA digestibilities measured with labeled diets were lower. A third experiment demonstrated that this was due to the rapid recycling of labeled dietary N in endogenous moieties, because 15N was found in blood within 10 min of consuming the labeled meal, within 50 min of consumption in pancreatic enzymes, 90 min in bile and 4 h in ¡leal mucins. We conclude that the use of 15N-labeled meals for determination of true ¡leal AA digestibilities is limited by the fast recycling of dietary N in endogenous secretions following a single 15N-labeled meal. The accuracy of results will depend on meaningful estimates of AA flow during a limited period and accurate estimates of 15N in AA. [less ▲]

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See detailRecently advanced computerized technology was applied to the investigation of morphometric, immunohistological and three-dimensional changes of the endometrial mucosa in order to evaluate quantitatively the effects of three doses of a new slow-release vaginal progesterone on the endometrium in post-menopausal women. A total of 20 menopausal women, deprived of ovarian function, were given oestrogen for 12 days and a combined therapy of oestrogen (administered orally) and progesterone for another 12 day period. Progesterone was administered vaginally through a new gel (Crinone) utilizing a bioadhesive, biocompatible polymer as a base to achieve a sustained release effect. An endometrial biopsy was taken before treatment, after oestrogen-only treatment and after the oestro-progestogen therapy. Before treatment, all the patients exhibited an atrophic endometrium. After oestrogen-only treatment, typical proliferative changes occurred: an increase in the endometrium thickness, an increase in the mitotic index, numerous cylinder-like glands and no coiled glands, and high concentrations of oestrogen receptors (ER) and progesterone receptors (PR). After the oestro-progestogen therapy, whatever the dose of progesterone given, a secretory transformation of the endometrial mucosa occurred, mitotic activity decreased significantly, more ramified and coiled glands were observed, and a decrease in PR content was noted in epithelial and stromal nuclei, and a decrease in PR content was also observed in epithelial nuclei but not in stromal nuclei. Accurate new techniques of image analysis have shown that crinone therapy could eliminate the proliferative effects of oestrogen treatment in post-menopausal women, despite doses as low as 45 mg of progesterone administered vaginally every other day. The results suggest that the sustained release effects of Crinone are clinically relevant.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise et al

in Human Reproduction (1996), 11(1), 224-8

A computerized morphometrical investigation was performed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologically the ... [more ▼]

A computerized morphometrical investigation was performed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologically the rectovaginal septum endometriotic nodule to peritoneal endometriosis. Mitotic activity, stromal vascularization and the epithelium/stroma ratio were found to be significantly different in peritoneal and rectovaginal endometriosis. The evaluation revealed a major role of glandular epithelium in rectovaginal nodules where the stroma sometimes appeared absent around glandular epithelium. The study demonstrated opposite effects of gonadotrophin-releasing hormone agonists (GnRHa) and lynestrenol on the two lesions. Indeed, in peritoneal endometriosis, after GnRHa therapy, our study demonstrated a lower rate of mitosis and poor stromal vascularization. The same drug was unable to induce the same effects in the nodule although, in contrast, lynestrenol has a strong effect on nodule vascularization. In conclusion, it is suggested that the rectovaginal adenomyotic nodule is a specific disease, different from peritoneal endometriosis. It is not the consequence of 'deep infiltrating' endometriosis but can probably develop from Mullerian rests present in the rectovaginal septum. [less ▲]

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See detailQuantitative measurement of metal ions concentration of proteins separated by electrophoresis
Weber, Georges ULg; Strivay, David ULg; Menendez, M. et al

in International Journal of PIXE (1996), 1-2

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the ... [more ▼]

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the electrophoresis, the gel is dried and each track is scanned with a 2.5 MeV proton beam which triggers metal X-ray fluorescence and then, allows to determine the type of metals contained in an electrophoretic band. For quantitative determination of the amount of the metal contained inside the band, the characteristic X-ray peak area is compared with those obtained with polyacrylamide gels doped with the same metal. The normalization has been achieved by using RBS measurements on the gel itself. The procedure presented seems to be a very useful multielementary method for the metal content analysis and for the determination of the metal amounts inside proteins after their separation by electrophoresis. Furthermore it allows to check if metals remain bound to proteins. [less ▲]

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See detailHyperfine structure of Sc I by Infrared Fourier Transform Spectroscopy
Aboussaïd, A.; Carleer, M.; Hurtmans, D. et al

in Physica Scripta (1996), 53

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See detailRole of the metallothioneins in metal regulation by the guillemot Uria aalge
Bouquegneau, Jean-Marie ULg; Debacker, Virginie ULg; Gobert, Sylvie ULg et al

in Comparative Biochemistry and Physiology. C : Comparative Pharmacology and Toxicology (1996), 113C(2), 135-139

Guillemots, like other seabird species living in the North Sea, appear to be heavily contaminated by copper. Metallothioneins are present in both liver and kidney but, at least in the specimens stranded ... [more ▼]

Guillemots, like other seabird species living in the North Sea, appear to be heavily contaminated by copper. Metallothioneins are present in both liver and kidney but, at least in the specimens stranded along the Belgian coast, fail to maintain constant the copper, zinc and cadmium load of the high molecular weight soluble proteins of both organs, stressing the potential toxic role of these metals, mainly copper. [less ▲]

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See detailA study of general practitioners' prescribing behaviour to the elderly in Wallonia, Belgium
Taziaux, P.; Franck, J.; Ludovicy, R. et al

in European Journal of Public Health (1996), 6(1)

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See detailQuel encadrement pour quelle qualité de l'enseignement?
Lafontaine, Dominique ULg

in Pilotinfo (1996), (13), 1-8

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See detailTaphocoenosis of miocene taxodiaceous wood from the Entre-Sambre-et-Meuse cryptokarsts (southern Belgium)
De Putter, T.; Roche, M.; Dupuis, C. et al

in N. Jb. Geol. Palaont. Abh. (1996), 202(2), 259-268

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See detailRetard neuromoteur et neuropsychologique: critères de recours à une prise en charge spécialisée
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia et al

in Percentile (1996), .(3), 103-107

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See detailBrain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease.
Mastrogiacomo, Frank; Bettendorff, Lucien ULg; Grisar, Thierry ULg et al

in Annals of Neurology (1996), 39

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See detailPollution des sols : interventions et responsabilités des pouvoirs publics
Delnoy, Michel ULg

in Sols contaminés, sols à décontaminer (1996)

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See detailA propos d'un syndrome de Cushing d'origine indéterminée
Geenen, Vincent ULg

in Actualité Médicale Belge (1996), 513

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See detailCaractéristiques des lésions résultant d'une pathologie périnatale
Dubru, Jean-Marie ULg; Leroy, Patricia; Misson, Jean-Paul ULg

in Acta Paediatrica Belgica (1996), 28(3), 203-204

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See detailRéactions physiologiques face à des conditions extrêmes de chaleur et d'humidité relative: Etude des effets de l'exercice
Art, Tatiana ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (1996), 28

The purpose of this study was to investigate the effect of a hot and humid environment on the pattern of breathing and the gas exchange in heavily exercising horses. Five healthy fit standardbred horses ... [more ▼]

The purpose of this study was to investigate the effect of a hot and humid environment on the pattern of breathing and the gas exchange in heavily exercising horses. Five healthy fit standardbred horses (493± 14 kg; 4± 0,5yrs) were investigated twice at eight days interval, once in temperated atmos¬pheric conditions (TC) (ambient temperature : 15o C; relative humidity : 55 %) and once in hot and humid conditions (HHC) (ambient temperature : 30°C; relative humidity : 75 %). The standardized treadmill exercise test consisted in 8 min warm-up and in 8 min exer¬cise (1 min at 1,7, 4, 7, 8, 9 and 10 m/sec and 2 min at 4 m/sec with a 6% slope). Respiratory airflow, tidal volume, respiratory frequency as well as the 02 and C02 fraction in the inspired and expired gases were continuously recorded, using 2 ultrasonic pneumo¬tachographs connected to a face mask and a mass spectrometer. Oxygen uptake (VO2, carbon dioxide output (VCO2,), respiratory quotient (RQ) and expired minute volume (VE.) as well as alveolar partial pressure in C02 (PAC02) were obtained on a breath-by--breath basis. The maximal values obtained during the highest intensity were used for the comparison between both tests. Heart rate and skip temperature were continuously recorded, using a heart rate recording system and a real time infrared thermographic unit, respecti¬vely. Venous blood was sampled before and 2 min after the completion of the test for hematological and biochemical analysis, namely plasma lactate (LA), beta-endorphins, cortisol (Cor). Running in HHC induced a significant decrease in peak VE, VO2, VCO2 and oxygen pulse, while RQ remained unchanged and PAC02 increased. The changes in skin temperature (ST), i.e. the difference between ST at rest and at 10 m/sec, was dramatically higher in HHC. As well, the test-induced changes, i.e. the differences between the values before and after the test, in Cor, beta-endorphins and LA values after the test were significantly higher. This study shows that performing a strenuous exercise in hot, humid conditions in unacclimatized horses induced a reduction of the aerobic capacity, i.e. decrease of the VO2 and increase of LA production. A relative hypoventilation could be partly responsible for this observation, but all the steps of the oxygen transport from the pulmonary ventilation to the muscle metabolism could also potentially be impaired in such conditions [less ▲]

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See detailReconnaissance des malformations et pathologies prénatales du système nerveux central
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia

in Acta Paediatrica Belgica (1996), 28(3), 204-215

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See detailNucleic acid detection by in situ molecular immunogold labeling procedures.
Thiry, Marc ULg

in Scanning Microscopy. Supplement (1996), 10

We have recently combined immunogold labeling procedures with molecular biology methods to pinpoint the precise locations of nucleic acids in biological material at the ultrastructural level. These new ... [more ▼]

We have recently combined immunogold labeling procedures with molecular biology methods to pinpoint the precise locations of nucleic acids in biological material at the ultrastructural level. These new immunocytological approaches involve the incorporation of labeled nucleotides in the nucleic acids present at the surface of ultrathin sections prior to immunogold labeling. The antibodies used recognize a nucleoside analogue (bromodeoxyuridine) or a hapten (biotin) employed to label nucleotides. Examples of high-resolution detection include DNA or RNA present in different substructures of cell nuclei, and in particular, in adenovirus-induced intranuclear regions of HeLa cells. In addition to being highly sensitive and specific, these new methods offer the possibility of studying the spatial distribution of nucleic acids in very well preserved, readily recognizable structures. [less ▲]

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See detailMarsilio Ficino and Political Syncretism in Ian McEwan's Black Dogs
Delville, Michel ULg

in Notes on Contemporary Literature (1996), XXIV(3), 11-12

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See detailTo be or not to be at home ? A neuropsychologica approach to delusion for place
Sellal, F.; Fontaine, S. F.; Van der Linden, Martial ULg et al

in Journal of Clinical & Experimental Neuropsychology (1996), 18

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See detailDemande d'indemnisation des dommages dus aux plans : éléments de recevabilité et de fondement
Delnoy, Michel ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1996)

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See detailCytochemistry of the tergite epicuticle of Glomeris marginata (Villers) (MYRIAPODA, DIPLOPODA): preliminary experimental results
Compère, Philippe ULg; Defise, Stéphane; Goffinet, Gerhard ULg

in Mémoires du Muséum d'Histoire naturelle (Paris) - Acta Myriapodologica (1996), 169

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See detailLa genèse du héros médiocre. Simenon à l'époque Fayard
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (1996), (8), 27-42

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See detailLanguage in adults with Down syndrome
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Down's Syndrome, Research and Practice : The Journal of the Sarah Duffen Centre (1996), 4(1), 3-14

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language ... [more ▼]

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language or some aspects of it beyond adolescence and during the adult years? This question is related to the issue of a critical period for language development raised by Eric Lenneberg (1967). Third, what is the effect of ageing on the language of persons with Down syndrome, including those who develop Alzheimer disease in old age? [less ▲]

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See detailImplicit learning in amnesic subjects: A comparison with a large group of normal control subjects
Wilson, B. A.; Green, R.; Teasdale, T. et al

in Clinical Neuropsychologist (1996), 10

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See detailFactors influencing the behavior of steel columns exposed to fire
Talamona, Didier; Kruppa, Joël; Franssen, Jean-Marc ULg et al

in Journal of Fire Protection Engineering (1996), 8(1), 31-43

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See detailGranuloma tuberculoide post-herpético en un paciente con leucemia linfocítica crónica
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Medicina Cutanea Ibero-Latino-Americana (1996), 24

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See detailL'image du mois. Angor spastique et lesion coronarienne moderee traitee par angioplastie avec stent.
Legrand, Victor ULg; Fernandez, R.

in Revue medicale de Liege (1996), 51(12), 737-9

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See detailA field observation on the influence of aggressive behaviour on mating success in the European grayling
Poncin, Pascal ULg

in Journal of Fish Biology (1996), 48(4), 802-804

The biggest male grayling present on a spawning area was strongly territorial and developed more aggressive behaviours than smaller males. However, its spawning frequency was similar to that of smaller ... [more ▼]

The biggest male grayling present on a spawning area was strongly territorial and developed more aggressive behaviours than smaller males. However, its spawning frequency was similar to that of smaller males. (C) 1996 The Fisheries Society of the British Isles [less ▲]

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See detailCardio-respiratory adjustments and arterial blood gases in exercising horses in crisis and in clinical remission
Art, Tatiana ULg; Anciaux, N.; Duvivier, H. et al

in Pferdeheilkunde (1996), 12(4), 717-718

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See detailAnalysis of structural members under elevated temperature conditions- Discussion
Franssen, Jean-Marc ULg

in Journal of Structural Engineering (1996), 10

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See detailLes "deux cultures" et la tâche de la philosophie
Bouquiaux, Laurence ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1996)

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See detailThe tilapia prolactin I gene: evolutionary conservation of the regulatory elements directing pituitary-specific expression
Poncelet, A. C.; Levavi-Sivan, B.; Muller, Marc ULg et al

in DNA & Cell Biology (1996), 15(8), 679-92

To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately ... [more ▼]

To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately upstream from the first exon. In footprinting experiments, three tilapia sequences are protected from DNase I digestion by rat pituitary extracts (base pair coordinates -643 to -593, -160 to -111, and -73 to -46). Computer analysis of the nucleotide sequence reveals significant homology to mammalian binding sites for Pit-1, a transcription factor that is known to mediate pituitary-specific expression of the PRL genes in mammals. The tiPRL I 5'-flanking sequences can direct transient expression of a linked luciferase reporter gene in transfected rat pituitary cell lines and tilapia pituitary primary cell cultures. Transient expression experiments with 5'-deletion mutants reveal three regulatory regions. Two have a stimulatory effect on transcription and one an inhibitory effect. Electrophoretic mobility-shift assays (EMSA) demonstrate that the rat Pit-1 factor specifically binds to tilapia DNA sequences. Several such tilapia Pit-1 binding sites mediate activation of a linked heterologous promoter in transfected rat and tilapia pituitary cells. As evidenced by EMSA, a Pit-1-like protein is present in tilapia pituitary extracts. All these data point to a high conservation of the molecular mechanisms involved in pituitary-specific expression of the PRL genes in vertebrates. [less ▲]

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See detailEffets du massage par appareil semi automatique : Etude scintigraphique et tonométrique
Crielaard, Jean-Michel ULg; Vanderthommen, Marc ULg; Dauchat, L. et al

in Kinésitherapie, les Annales (1996), 23(3), 102-105

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See detailFast Computation of morphological operations with arbitrary structuring elements
Van Droogenbroeck, Marc ULg; Talbot, Hugues

in Pattern Recognition Letters (1996), 17(14), 1451-1460

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See detailImprovement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Tassoudji, Nazli ULg et al

in Journal of Dermatological Treatment (1996), 7

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This ... [more ▼]

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This study was conducted in 20 men who used a lotion containing the antimicrobials, piroctone olamine and triclosan, regularly for 18 months. At entry, mild pruritus and abnormal hair loss were reported by the volunteers. During treatments, pruritus resolved rapidly. Comparison of clinical photographs and trichograms taken at 3-month intervals suggested signs of hair regrowth with moderate increase in density of transitional hairs. Biopsies taken at 6-month intervals were processed for immunohistochemistry. There was a decrease in the density of activated T cells in the region of the follicular infrainfundibulum and isthmus over time. UgG deposits found within the epithelial sheaths at entry to the study were absent in the subsequent biopsies. The volume of the sebaceous glands, as assessed by computerized morphometry, was not modified by the treatment. It was concluded that inflammation associated with AGA transitional hairs may be driven by the presence of microorganisms harboured in the infrainfundibulum. They may modulate the severity of AGA and may potentially be controllable. This offers a new possibility of prevention and partial reversal of hair loss in AGA. [less ▲]

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See detailThe current situation of wild mammals in Belgium: an outline
Libois, Roland ULg

in Hystrix: the Italian Journal of Mammalogy (1996), 8(1-2), 35-41

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better ... [more ▼]

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better understanding of the current status of the different species. Conservation measures were olso proposed to the political authorities who thereafter edicted a legal protection of the most vulnerable species. Unfortunately, habitat protection is rather unachieved and the situation of the most endangered species is still getting worse. [less ▲]

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See detailLe juste entre l’universel et le contextuel. Le débat anglo-saxon contemporain et son apport pour une approche socio-anthropologique du sens ordinaire de la justice dans un pays de tradition arabo-islamique
Nachi, Mohamed ULg

in Social Science Information/Information sur les sciences sociales (1996), 35(2), 389-425

Le présent article met en évidence les pertinences de l'idée d'un recours à la pensée philosophique pour mieux asseoir une approche socio-anthropologique du sens ordinaire de la justice. Pour se faire, l ... [more ▼]

Le présent article met en évidence les pertinences de l'idée d'un recours à la pensée philosophique pour mieux asseoir une approche socio-anthropologique du sens ordinaire de la justice. Pour se faire, l'auteur se propose d'analyser les présupposés épistémologiques et théoriques des trois courants philosophiques anglo-saxons qui placent au centre de leurs réflexions la question de la justice. Il montre, ce faisant, les limites de la thèse "libérale" et les apports respectifs des thèses marxienne et communautarienne. Certaines positions théoriques d'auteurs dits communautariens se révèlent plus pertinentes dans la mesure où elles permettent de situer la question de la justice à l'intérieur d'une tradition et de lui conférer un contenu socio-historique. Elles débouchent, de ce fait, sur une conception pluraliste de la justice qui permet de prendre en compte les données empiriques propres à une société de tradition arabo-islamique. [less ▲]

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1996), 37

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See detailMeasurement of tomato firmness by using a non-destructive mechanical sensor
Lesage, Patrick; Destain, Marie-France ULg

in Postharvest Biology & Technology (1996), 8

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate ... [more ▼]

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate lever mechanism. A highly significant correlation exists between firmness measurements performed with this device and the Stable Micro Systems (SMS), fitted with the same plunger dimaeter. Using the Cantifruit, data related to firmness variability and changes are easily obtained. The firmness of tomatoes varies about 12 % around its circumference. In a single lot of tomatoes picked at the same time, the variability may exceed 25 %. If the tomatoes are stored at 4-5 °C and 92-99 % relative humidity (RH), their firmness decreases by about 20 % over ten days. [less ▲]

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See detailTheoretical Radiative Lifetimes of 3p3(4S°)4s5S° and 3S° States in S I
Biémont, Emile ULg; Storey, P. J.; Zeippen, C. J.

in Astronomy and Astrophysics (1996), 309

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See detailBrain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
Mastrogiacomo, Frank; Lindsay, J. Gordon; Bettendorff, Lucien ULg et al

in Annals of Neurology (1996), 39

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See detailMiospores from the type locality of the middle Famennian Esneux Formation in the Ourthe Valley, eastern Belgium
Loboziak, S; Avkhimovich, V I; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1996), 119(2), 111-118

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See detailVariations interannuelles des précipitations mensuelles et leur répartition spatiale en Belgique
Alexandre, Jean ULg; Mabille, Georges ULg; Erpicum, Michel ULg

in Publication Association Internationale de Climatologie (1996), 9

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See detailRelationship between Parathion and Paraoxon Toxicokinetics, Lung Metabolic Activity, and Cholinesterase Inhibition in Guinea Pig and Rabbit Lungs
Lessire, Françoise ULg; Gustin, Pascal ULg; Delaunois, Annie et al

in Toxicology and Applied Pharmacology (1996), 138(2), 201-210

Kinetic parameters of parathion and paraoxon uptake were determined in isolated and perfused rabbit and guinea pig lungs. They were related to organophosphate-induced lung cholinesterase inhibition. A ... [more ▼]

Kinetic parameters of parathion and paraoxon uptake were determined in isolated and perfused rabbit and guinea pig lungs. They were related to organophosphate-induced lung cholinesterase inhibition. A single pass procedure was used to perfuse the lungs with an artificial medium perfusate containing paraoxon or parathion. The paraoxon and parathion concentrations were determined in the effluents collected at chosen intervals over an 18-min period beginning at the start of perfusion. Three inflowing concentrations (1 nmol/ml, 10 nmol/ml, and 20 nmol/ml) were tested in guinea pig lungs and one (10 nmol/ml) in rabbit lungs. Cholinesterase activity was determined at time 0 and at the end of the experiment. The lungs abundantly extracted paraoxon and parathion over the perfusion period. The extraction ratio was consistently greater in guinea pig than in rabbit lungs. The uptake velocity varied biexponentially in time, suggesting the existence of two compartments. Initial uptake velocities (A, B) and slopes (alpha and beta) were calculated for both compartments. In guinea pigs, A, B and A + B increased proportionally to the supply rate of paraoxon and parathion while a and b remained constant. No significant difference was observed between parathion and paraoxon uptake kinetics. Parameter B was the only one to differ significantly between the two species (rabbits: 8.19 +/- 1.53 for parathion and 6.85 +/- 1.26 for paraoxon; guinea pigs: 12.75 +/- 0.88 for parathion and 15.02 +/- 3.84 for paraoxon). In the lungs of both species, there was a linear relation between y, the percentage of cholinesterase inhibition induced by either organophosphate, and X, the total amount of drug taken up by the lung tissue (in nmol/g/18 min). The following equations were obtained: y = 0.128 x + 0.979 (R2 = 0.89, p < 0.001 for paraoxon); y = 0.120 x - 6.57 (R2 = 0.82, p < 0.005 for parathion). No difference was observed between the two organophosphates. After treatment with the cytochrome P450 inhibitor piperonyl butoxide, the above relations ceased to apply, but this treatment did not influence the kinetics of paraoxon and parathion uptake. The IC50 value calculated for paraoxon, i.e., the paraoxon concentration required to produce 50% inhibition of lung cholinesterase activity, was similar for guinea pigs (2.22 10(-7) +/- 0.22 M) and rabbits (2.36 10(-7) +/- 0.24 M). In conclusion, the biexponential evolution of the velocity of paraoxon and parathion uptake by the lungs thus demonstrates the presence of two pools. The lower extraction ratios calculated for rabbit lungs reflect the lower initial uptake velocity of the second compartment. In the range of concentrations investigated in guinea pigs, no saturable mechanism could be demonstrated for paraoxon and parathion. Cytochrome P450-related lung metabolic activity, through which parathion is converted to paraoxon, appears as a major step in parathion-induced lung cholinesterase inhibition, although it does not appear to affect parathion toxicokinetics [less ▲]

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See detailMaurice Streel, an annotated list of his publications.
Steemans, Philippe ULg; Loboziak, S

in Annales de la Société Géologique de Belgique (1996), 117

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See detailHigh rotational excitation of NO infrared thermospheric airglow: A signature of superthermal nitrogen atoms?
Hubert, Benoît ULg; Gérard, Jean-Claude ULg; Shematovich, Valeri I et al

in Geophysical Research Letters (1996), 23

The reaction between superthermal N([SUP]4[/SUP]S) atoms produced by exothermic processes and O[SUB]2[/SUB] has been proposed to explain observations of highly rotationally excited nitric oxide in the ... [more ▼]

The reaction between superthermal N([SUP]4[/SUP]S) atoms produced by exothermic processes and O[SUB]2[/SUB] has been proposed to explain observations of highly rotationally excited nitric oxide in the sunlit thermosphere. We examine the importance of this mechanism using a detailed calculation of the fast N([SUP]4[/SUP]S) atoms energy distribution. It is shown that the hot thermal N atoms are able to produce rotationally excited NO in the upper thermosphere through the reaction of O[SUB]2[/SUB] with N([SUP]4[/SUP]S). By contrast, near the NO peak at 110 km, the Maxwellian nitrogen atoms produce substantially less rovibrationally excited NO than the superthermal component. Consequently, the non Maxwellian N([SUP]4[/SUP]S) atoms show a clear spectral signature in the (1-0) and (2-1) bandheads at this altitude. The calculated rovibrationally excited NO concentration at 140 km is shown to be consistent with the value derived from the analysis of infrared airglow spectra. [less ▲]

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See detailExhaustion of blood glucose response and enhancement of insulin response after repeated glucagon injections in type-2 diabetes: potentiation by progressive hyperglycemia.
Castillo, M. J.; Scheen, André ULg; Paolisso, G. et al

in Annales d'Endocrinologie (1996), 57(5), 395-402

AIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon injections in Type-2 (non-insulin-dependent) diabetic patients. METHODS: In overnight fasted Type-2 diabetic patients ... [more ▼]

AIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon injections in Type-2 (non-insulin-dependent) diabetic patients. METHODS: In overnight fasted Type-2 diabetic patients, three i.v. glucagon (1 mg) injections were given as a bolus at two-hour intervals. In the hour preceding each glucagon injection, 6 patients received saline and they were tested at near-baseline blood glucose levels, while 8 patients received a glucose-controlled glucose infusion and they were tested at increasing blood glucose levels (7.5 +/- 0.2, 12.9 +/- 0.5 and 18.7 +/- 0.7 mmol/l). Blood samples were collected at 0, 3, 5, 10, 15, 30 and 60 min after each glucagon injection. RESULTS: In the patients tested at near-baseline blood glucose levels, the blood glucose rise induced by glucagon was smaller after repeated injections. By contrast, the B-cell response to glucagon was well preserved. In the patients tested at increasing blood glucose levels, the blood glucose response to glucagon was abolished after repeated injections. By contrast, the B-cell response was significantly potentiated. The respective areas under the curve of plasma insulin levels in response to glucagon were 563 +/- 72, 1047 +/- 154 and 1844 +/- 305 m U x 30 min/l (p < 0.001). CONCLUSION: In Type-2 (non-insulin-dependent) diabetic patients, repeated glucagon injections, even when administered in a short (4 h) period of time, do not exhaust the B-cell. Endogenous insulin secretion is even potentiated at increasing blood glucose levels. By contrast, the hyperglycemic response to glucagon is significantly abolished, particularly at high blood glucose levels. [less ▲]

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See detailA Possible Role for the Alpha 1-->3 Galactosyl Epitope and the Natural Anti-Gal Antibody in Oncogenesis
Gollogly, L.; Castronovo, Vincenzo ULg

in Neoplasma (1996), 43(5), 285-9

Glycoconjugates and their antibodies are vital components of host-tumor interaction. This review concentrates on the oncological implications of research concerning the alpha gal triad; the alpha 1-->3 ... [more ▼]

Glycoconjugates and their antibodies are vital components of host-tumor interaction. This review concentrates on the oncological implications of research concerning the alpha gal triad; the alpha 1-->3 galactosyl epitope (alpha Gal), the enzyme responsible for its construction, alpha 1,3 galactosyl transferase (alpha 1-3GT), and its associated antibody: anti-gal. Alpha gal epitopes, previously assumed to be absent from human tissue, have been demonstrated on several human cancer cell lines, senescent red blood cells, and Graves' disease thyrocytes. Alpha-gal presence on neoplastic lines is correlated with increased metastatic formation in animal models. The mechanisms of human response to these neoantigens are complex, as natural anti-gal antibodies exist in high titers in normal sera, thus predicting immunological recognition of cells expressing alpha gal epitopes. Hypotheses vary regarding the pathogenic contributions of metastasis-associated phenomena such as de novo expression of alpha gal and its unmasking by desialylation. The means by which alpha gal is sporadically expressed in human tissue remain unknown, as the galactosyl transferase which produces this epitope in constitutively expressive animals has undergone significant mutation at the genomic level in humans. Pathological re-expression is presumed to require permissive changes at a cellular level. Detailing these alterations is a prerequisite to the comprehension of the metastatic phenotype. In this context, the possibility of therapeutic strategies affecting alpha gal expression are also discussed. [less ▲]

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See detailDefective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis.
Cazzola, M.; Ponchio, L.; de Benedetti, F. et al

in Blood (1996), 87(11), 4824-30

Systemic-onset juvenile chronic arthritis (SoJCA) is associated with high levels of circulating interleukin-6 (IL-6) and is frequently complicated by severe microcytic anemia whose pathogenesis is unclear ... [more ▼]

Systemic-onset juvenile chronic arthritis (SoJCA) is associated with high levels of circulating interleukin-6 (IL-6) and is frequently complicated by severe microcytic anemia whose pathogenesis is unclear. Therefore, we studied 20 consecutive SoJCA patients with hemoglobin (Hb) levels <12 g/dL, evaluating erythroid progenitor proliferation, endogenous erythropoietin production, body iron status, and iron supply for erythropoiesis. Hb concentrations ranged from 6.5 to 11.9 g/dL. Hb level was directly related to mean corpuscular volume (r = .82, P < .001) and inversely related to circulating transferrin receptor (r = -.81, P < .001) suggesting that the severity of anemia was directly proportional to the degree of iron-deficient erythropoiesis. Serum ferritin ranged from 18 to 1,660 microgram/L and was unrelated to Hb level. Bone marrow iron stores wore markedly reduced in the three children investigated, and they also showed increased serum transferrin receptor and normal-to-high serum ferritin. All 20 patients had elevated IL-6 levels and normal in vitro growth of erythroid progenitors. Endogenous erythropoietin (epo) production was appropriate for the degree of anemia as judged by both the observed to predicted log (serum epo) ratio 10.95 +/- 0.12) and a comparison of the serum epo-Hb regression found in these subjects with that of thalassemia patients. Multiple regression analysis showed that serum transferrin receptor was the parameter most closely related to hemoglobin concentration: variation in circulating transferrin receptor explained 61% of the variation in Hb level (P < .001). In 10 severely anemic patients, amelioration of anemia following intravenous iron administration resulted in normalization of serum transferrin receptor. Defective iron supply to the erythron rather than blunted epo production is the major cause of the microcytic anemia associated with SoJCA. A true body-iron deficiency caused by decreased iron absorption likely complicates long-lasting inflammation in the most anemic children, and this can be recognized by high serum transferrin receptor levels. Although oral iron is of no benefit, intravenous iron saccharate is a safe and effective means for improving iron availability for erythropoiesis and correcting this anemia. Thus, while chronically high endogenous IL-6 levels do not appear to blunt epo production, they are probably responsible for the observed abnormalities in iron metabolism. Anemia of chronic disease encompasses a variety of anemic conditions whose peculiar features may specifically correlate with the type of cytokine(s) predominantly released. [less ▲]

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