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See detailLa station de l'Hermitage à Huccorgne: un habitat gravettien de plein-air en Belgique
Straus, Lawrence; Otte, Marcel ULg; Noiret, Pierre ULg et al

in Notae Praehistoricae (2000), 20

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See detailConstruire l'esprit du dauphin
Servais, Véronique ULg

in Terrain (2000), 34

Comparisons are made of how the dolphin’s “mind” is “constructed” in six interactional contexts distinguished by the degree of participation (in the ethnological sense of the term) by human beings or even ... [more ▼]

Comparisons are made of how the dolphin’s “mind” is “constructed” in six interactional contexts distinguished by the degree of participation (in the ethnological sense of the term) by human beings or even by the dolphins themselves: the study of the brain, the study of sensorial capabilities, research on cognition, naturalistic observations, communication among dolphins, and meetings on the high sea. On the basis of these comparisons, it is argued that whether or not people attribute a “mind” to the dolphin very much depends on the degree of likeness that they recognize with these animals, which, in turn, depends on the person’s capacity to let himself be “affected” by them. [less ▲]

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See detailSynthesis of an array antenna for hyperthermia applications
V Sabariego, Ruth ULg; Landesa, Luis; Obelleiro, Fernando

in IEEE Transactions on Magnetics (2000), 36(4), 1696-1699

In the present work the synthesis of an array antenna for hyperthermia treatment is developed. The selected antenna is an array antenna surrounded by a semicircular reflector which has shown to ease the ... [more ▼]

In the present work the synthesis of an array antenna for hyperthermia treatment is developed. The selected antenna is an array antenna surrounded by a semicircular reflector which has shown to ease the penetration and focalization in malignant biological tissues. A bolus is introduced as a protection in order to avoid an increasing heat hazard of superficial healthy tissues. The electric field within the biological medium will be modeled by means of the well known method of moments. The electromagnetic coupling problem is expressed in a closed form, enabling both a synthesis and an optimization procedure to be performed. Numerical results are included, illustrating the capabilities of the array antenna. [less ▲]

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See detailComparaison de l'usage d'huiles d'origine végétale ou minérale pour la lubrification de chaines de tronconneuse.
Bieswal, Marc; Debouche, Charles ULg; van Belle, Laurent

in Silva Belgica (2000), 107(2), 18-21

Des études en laboratoire ont montré que les huiles végétales présentent un pouvoir lubrifiant supérieur aux huiles minérales dans le domaine de la lubrification limite (Kabuya 1995). Par ailleurs, des ... [more ▼]

Des études en laboratoire ont montré que les huiles végétales présentent un pouvoir lubrifiant supérieur aux huiles minérales dans le domaine de la lubrification limite (Kabuya 1995). Par ailleurs, des chiffres avancés dans la littérature ou par des fournisseurs de lubrifiants annoncent la possibilité de réduire la consommation de lubrifiant en passant à un lubrifiant à base d'huile végétale. Des chiffres de réduction d'usure sont aussi avancés par des constructeurs de tronçonneuses. L'essai décrit dans cet article n'a pas permis de confirmer ces réductions de consommation et de frottement. [less ▲]

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See detailExcess atmospheric carbon dioxide transported by rivers into the Scheldt Estuary
Abril, Gwenaël; Etcheber, Henri; Borges, Alberto ULg et al

in Comptes Rendus de l'Académie des Sciences de Paris (2000), 330

The transport of excess atmospheric CO2 (defined as the fraction of dissolved inorganic carbon (DIC) that can escape as CO2 to the atmosphere due to water-air equilibration), by the five rivers entering ... [more ▼]

The transport of excess atmospheric CO2 (defined as the fraction of dissolved inorganic carbon (DIC) that can escape as CO2 to the atmosphere due to water-air equilibration), by the five rivers entering the Scheldt estuary is investigated. Excess CO2 originates from both respiration in the soil and the river and represents 10 % of the DIC and 6 % of the total carbon input into the estuary. The ventilation of this CO2 in the estuary is however a minor contribution (10 %) to the total estuarine emission to the atmosphere, compared to heterotrophic activity and acidification due to nitrification within the estuarine zone. [less ▲]

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See detailLes aspects precliniques des therapeutiques anti-angiogenes
Noël, Agnès ULg; Foidart, Jean-Michel ULg

in Bulletin de l'Académie Nationale de Médecine (2000), 184(3), 569-77578

Tumor angiogenesis is one of the most important fields of cancer research. It is important to identify the putative targets for antiangiogenic strategies. To date, a number of angiogenic agents have been ... [more ▼]

Tumor angiogenesis is one of the most important fields of cancer research. It is important to identify the putative targets for antiangiogenic strategies. To date, a number of angiogenic agents have been identified: bFGF, the different VEGF isoforms, integrins, proteases (matrix metalloproteases and serine proteases),... Furthermore, several physiological anti-angiogenic agents have been isolated such as endostatin, angiostatin, 16 K prolactin,.... The recent development of mice deficient for one gene involved during angiogenesis gives a new insight into the molecular mechanisms regulating this process. It leads to the identification of plasminogen activator inhibitor-1 or PAI-1 as a new target for tumor treatment. Although, PAI-1 is very attractive as a target for new therapeutic strategies, a better understanding of its mechanism of action is needed urgently. [less ▲]

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See detailProteolytic cleavage confers nitric oxide synthase inducing activity upon prolactin
Corbacho, A. M.; Nava, G.; Eiserich, J. P. et al

in Journal of Biological Chemistry (2000), 275(18), 13183-6

Prolactin (PRL), originally associated with milk secretion, is now known to possess a wide variety of biological actions and diverse sites of production beyond the pituitary. Proteolytic cleavage is a ... [more ▼]

Prolactin (PRL), originally associated with milk secretion, is now known to possess a wide variety of biological actions and diverse sites of production beyond the pituitary. Proteolytic cleavage is a common post-translational modification that can either activate precursor proteins or confer upon the peptide fragment unique biological actions not exerted by the parent molecule. Recent studies have demonstrated that the 16-kDa N-terminal proteolytic cleavage product of PRL (16K-PRL) acts as a potent inhibitor of angiogenesis. Despite previous demonstrations of 16K-PRL production in vivo, biological functions beyond its antiangiogenic actions remain unknown. Here we show that 16K-PRL, but not full-length PRL, acts to promote the expression of the inducible isoform of nitric oxide synthase (iNOS) and nitric oxide (*NO) production by pulmonary fibroblasts and alveolar type II cells with potency comparable with the proinflammatory cytokines interleukin-1beta, interferon gamma, and tumor necrosis factor alpha. The differential effect of 16K-PRL versus PRL occurs through a receptor distinct from known PRL receptors. Additionally, pulmonary fibroblasts express the PRL gene and endogenously produce 16K-PRL, suggesting that this pathway may serve both autocrine and paracrine roles in the regulation of *NO production. These results reveal that proteolytic cleavage of PRL confers upon this classical hormone potent iNOS inducing activity, suggesting its role in inflammatory/immune processes. [less ▲]

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See detailRéflexions sur l'avenir de la Belgique et de Bruxelles
Martiniello, Marco ULg; Swyngedouw, Marc

in Utinam : Revue de Sociologie et d'Anthropologie (2000), 3

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See detailImmunocastration of farm animals
Portetelle, Daniel ULg; Haezebroeck, Valérie; Mortiaux, Frédéric et al

in Bases (2000), 4

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See detailCrossing a "Human River of Shattered Lives": Caryl Phillips's Diasporic Fiction/Visions
Ledent, Bénédicte ULg

in Literary Criterion (2000), 35(1-2), 157-169

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See detailDescription de cas de chondrodystrophie dans trois exploitations de poulets label
Korsak, Nicolas; Marlier, Didier ULg; Mathieu, F. et al

in Annales de Médecine Vétérinaire (2000), 144(6), 415-420

The present paper describes chondrodystrophy (perosis) in three poultry units producing labelled chickens. An unilateral deviation of a hind leg along with a tumefaction of the tarsal joint appeared in 4 ... [more ▼]

The present paper describes chondrodystrophy (perosis) in three poultry units producing labelled chickens. An unilateral deviation of a hind leg along with a tumefaction of the tarsal joint appeared in 4-day- to 4-week-old birds; 5 to 50% of the animals were affected. The growth rate was reduced and cachexia was also observed. There were also breast blisters. Chemical analyses were carried out on the poultry feed in two of the units. The manganese content was below the requirements at about 35 mg/kg; in one unit, the ionic balance (Na+K-Cl) was insufficient along with a too narrow Ca/P. The insufficient supply in manganese was corrected by the addition of manganese sulfate in water at a rate of 120 g/litre of water. Manganese sulfate was also added in the feedstuff at a rate of 120 g/ton. [less ▲]

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See detailComments on the criticisms of Coquel and Abdesselam-Rouighi (1999) to the paper of Loboziak et al. (1998)
Loboziak, S; Melo; Streel, Maurice ULg

in Annales de la Société Géologique du Nord (2000), 8

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See detailTechnical efficiency of European railways: a distance function approach
Coelli, Tim; Perelman, Sergio ULg

in Applied Economics (2000), 32

This study has two principal objectives. The first objective is to measure and compare the performance of European railways. The second objective is to illustrate the usefulness of econometric distance ... [more ▼]

This study has two principal objectives. The first objective is to measure and compare the performance of European railways. The second objective is to illustrate the usefulness of econometric distance functions in the analysis of production in multioutput industries, where behavioural assumptions such as cost minimization or profit maximization, are unlikely to be applicable. Using annual data on 17 railways companies during 1988± 1993, multioutput distance functions are estimated using corrected ordinary least squares (COLS). The resulting technical efficiency estimates range from 0.980 for the Netherlands to 0.784 for Italy, with a mean of 0.863. The distance function results are also compared with those obtained from single-output production functions, where aggregate output measures are formed using either total revenue or a Tornqvist index. The results obtained indicate substantial differences in parameter estimates and technical efficiency rankings, casting significant doubt upon the reliability of these single-output models, particularly when a total revenue measure is used to proxy aggregate output. [less ▲]

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See detailLa carte des émotions : exercice structuré
Faulx, Daniel ULg

in Cahiers Internationaux de Psychologie Sociale (2000), (45), 98-103

Cet outil permet d'identifier et d'analyser la présence, la circulation et la gestion des émotions au sein d'une équipe de travail ou d'un groupe. Il propose différents modes de mesure de l'émotion au ... [more ▼]

Cet outil permet d'identifier et d'analyser la présence, la circulation et la gestion des émotions au sein d'une équipe de travail ou d'un groupe. Il propose différents modes de mesure de l'émotion au sein des groupes, et constitue à ce titre à la fois un outil de mesure et d'intervention ou de développement. [less ▲]

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See detailSpatial autocorrelation of allozyme and quantitative markers within a natural population of Centaurea jacea (Asteraceae)
Hardy, O. J.; Vanderhoeven, SONIA ULg; Meerts, P. et al

in Journal of Evolutionary Biology (2000), 13(4), 656-667

This paper compares the fine-scale genetic structure of quantitative traits and allozyme markers within a natural population of Centaurea jacea s.l. To that end, a spatial autocorrelation approach is ... [more ▼]

This paper compares the fine-scale genetic structure of quantitative traits and allozyme markers within a natural population of Centaurea jacea s.l. To that end, a spatial autocorrelation approach is developed based on pairwise correlation coefficients between individuals and using sib families. Statistical properties of the proposed statistics are investigated with numerical simulations. Our results show that most quantitative traits have a significant spatial structure for their genetic component. On average, allozyme markers and the genetic component of quantitative traits have similar patterns of spatial autocorrelation that are consistent with a neutral model of isolation by distance. We also show evidence that environmental heterogeneity generates a spatial structure for the environmental component of quantitative traits. Results are discussed in terms of mechanisms generating spatial structure and are compared with those obtained on a large geographical scale. [less ▲]

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See detailThe antiangiogenic factor 16K PRL induces programmed cell death in endothelial cells by caspase activation
Martini, J. F.; Piot, C.; Humeau, L. M. et al

in Molecular Endocrinology (2000), 14(10), 1536-49

We asked whether the antiangiogenic action of 16K human PRL (hPRL), in addition to blocking mitogen-induced vascular endothelial cell proliferation, involved activation of programmed cell death. Treatment ... [more ▼]

We asked whether the antiangiogenic action of 16K human PRL (hPRL), in addition to blocking mitogen-induced vascular endothelial cell proliferation, involved activation of programmed cell death. Treatment with recombinant 16K hPRL increased DNA fragmentation in cultured bovine brain capillary endothelial (BBE) and human umbilical vein endothelial (HUVE) cells in a time- and dose-dependent fashion, independent of the serum concentration. The activation of apoptosis by 16K hPRL was specific for endothelial cells, and the activity of the peptide could be inhibited by heat denaturation, trypsin digestion, and immunoneutralization, but not by treatment with the endotoxin blocker, polymyxin-B. 16K hPRL-induced apoptosis was correlated with the rapid activation of caspases 1 and 3 and was blocked by pharmacological inhibition of caspase activity. Caspase activation was followed by inactivation of two caspase substrates, poly(ADP-ribose) polymerase (PARP) and the inhibitor of caspase-activated deoxyribonuclease (DNase) (ICAD). Furthermore, 16K hPRL increased the conversion of Bcl-X to its proapoptotic form, suggesting that the Bcl-2 protein family may also be involved in 16K hPRL-induced apoptosis. These findings support the hypothesis that the antiangiogenic action of 16K hPRL includes the activation of programmed cell death of vascular endothelial cells. [less ▲]

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See detailFeasability of monitoring neutrophils'migration into the lung with immunoscintigraphy: preliminary study
Votion, Dominique ULg; Harmegnies, N. F.; Lekeux, Pierre ULg

in European Journal of Nuclear Medicine (2000), 27

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See detailA Fast Method To Predict Protein Interaction Sites From Sequences
Gallet, X.; Charloteaux, Benoît ULg; Thomas, Annick ULg et al

in Journal of Molecular Biology (2000), 302(4), 917-26

A simple method for predicting residues involved in protein interaction sites is proposed. In the absence of any structural report, the procedure identifies linear stretches of sequences as "receptor ... [more ▼]

A simple method for predicting residues involved in protein interaction sites is proposed. In the absence of any structural report, the procedure identifies linear stretches of sequences as "receptor-binding domains" (RBDs) by analysing hydrophobicity distribution. The sequences of two databases of non-homologous interaction sites eliciting various biological activities were tested; 59-80 % were detected as RBDs. A statistical analysis of amino acid frequencies was carried out in known interaction sites and in predicted RBDs. RBDs were predicted from the 80,000 sequences of the Swissprot database. In both cases, arginine is the most frequently occurring residue. The RBD procedure can also detect residues involved in specific interaction sites such as the DNA-binding (95 % detected) and Ca-binding domains (83 % detected). We report two recent analyses; from the prediction of RBDs in sequences to the experimental demonstration of the functional activities. The examples concern a retroviral Gag protein and a penicillin-binding protein. We support that this method is a quick way to predict protein interaction sites from sequences and is helpful for guiding experiments such as site-specific mutageneses, two-hybrid systems or the synthesis of inhibitors. [less ▲]

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See detailPharma-clinics. Le medicament du mois. La levofloxacine (Tavanic).
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(11), 1015-7

Levofloxacin, the (-)-(S)-enantiomer isolated from the racemate ofloxacin, is launched by Aventis under the trade name of Tavanic. This new oral and parenteral antibiotic belongs to the fluoroquinolone ... [more ▼]

Levofloxacin, the (-)-(S)-enantiomer isolated from the racemate ofloxacin, is launched by Aventis under the trade name of Tavanic. This new oral and parenteral antibiotic belongs to the fluoroquinolone family and exerts a bactericidal activity upon a large spectrum of microorganisms, including Gram negative and Gram positive bacilli (among which Streptococcus pneunomiae), and atypical respiratory pathogens. It also has interesting pharmacokinetic properties. Besides the classical indications of other fluoroquinolones (especially complicated urinary tract infections, including pyelonephritis, and severe skin and soft tissue infections), levofloxacin is indicated for the treatment of acute sinusitis, acute exacerbations of chronic bronchitis and community-acquired pneumonia. [less ▲]

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See detailPharma-clinics. Le medicament du mois. La moxonidine (Moxon).
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(1), 61-3

Moxonidine (Moxon, Solvay Pharma) is the first member of a new class of centrally-acting antihypertensive agents. The selective activation of central I1 imidazoline receptors results in an inhibition of ... [more ▼]

Moxonidine (Moxon, Solvay Pharma) is the first member of a new class of centrally-acting antihypertensive agents. The selective activation of central I1 imidazoline receptors results in an inhibition of peripheral sympathetic activity and produces arterial vasodilatation. Moxonidine is indicated in the treatment of essential arterial hypertension, at a usual daily dose of 0.4 mg (initial dose of 0.2 mg/day), in one administration per day. Its tolerance profile is better than that of other centrally-acting antihypertensive agents which stimulate alpha-2 adrenergic receptors, and similar to that of medications of other classes. As monotherapy, the antihypertensive efficacy of moxonidine is similar to that of most other antihypertensive agents. In case of insufficient response, moxonidine may be associated with other antihypertensive compounds, which leads to a better efficacy with no deterioration of its good tolerance profile. [less ▲]

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See detailTaurine and ethanol preference : a microdialysis study using Sardinian alcohol-preferring and non-preferring rats
Quertemont, Etienne ULg; Lallemand, Frédéric; Colombo, Giancarlo et al

in European Neuropsychopharmacology (2000), 10

Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the ... [more ▼]

Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the first 60-min period. In taurine-supplemented rats, a reduced aversion for high ethanol doses was observed in a place conditioning paradigm, suggesting that taurine may be implicated in the regulation of some adverse effects of ethanol. The present study compares the effects of acute ethanol injections (1.0 and 2.0 g/ kg, i.p.) on taurine nucleus accumbens microdialysate content in Sardinian ethanol-preferring (sP) and Sardinian ethanol-non preferring (sNP) rats. While neither saline nor 1.0 g/kg ethanol injections had significant effect on taurine microdialysate concentration, 2.0 g/kg ethanol administration induced a rapid and significant increase in taurine microdialysate content in both sP and sNP rats. However, this ethanol-induced taurine release was significantly reduced in sP rats by comparison to sNP rats. As taurine is suggested to be released by brain cells to modulate different ethanol adverse effects, this lower taurine responsiveness to ethanol in sP rats by comparison to both sNP and Wistar rats may be a relevant indicator of reduced ethanol aversive effects in such animals and therefore be related to their higher alcohol consumption. [less ▲]

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See detailPhylogenetic analysis of the pearlfish Carapini (Ophidiiformes, Carapidae)
Parmentier, Eric ULg; Castillo Cabello, Gabriel ULg; Chardon, Michel ULg et al

in Acta Zoologica (2000), 81

Fishes of the tribe Carapini (Encheliophis and Carapus) share a noteworthy peculiarity: they shelter in holothurian echinoderms or bivalve hosts. Some species are considered parasitic, others commensal ... [more ▼]

Fishes of the tribe Carapini (Encheliophis and Carapus) share a noteworthy peculiarity: they shelter in holothurian echinoderms or bivalve hosts. Some species are considered parasitic, others commensal. This study focuses on the phylogeny of the tribe, using two other Carapidae species as an outgroup (Snyderidia canina and Onuxodon fowleri). Insofar as possible, the selected anatomical and behavioural characters where chosen in an ecomorphological perspective, as features that could be responses to various lifestyle-related constraints. Our character selection also took into account the fact that some features are (presumably) linked. Such features were grouped together as a single trait to avoid their overvaluation. This methodology enabled us to separate commensals from parasites, the former belonging to Carapus and the latter to Encheliophis. Carapus species reflect in their morphology the constraints imposed by a diet of hard, mobile, elusive prey, showing predator-type features: a strong dentition, a wide mouth opening, a robust food intake apparatus. On the other hand, the endoparasitic Encheliophis species show a generally weaker buccal apparatus and narrow mouth opening, in relation to the different constraints of their lifestyle where the diet constraints are less pronounced: they eat body parts of their host. We propose changes in both generic diagnoses and transfer three species from Encheliophis to Carapus. [less ▲]

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See detailStructure et fonctionnement de la mémoire : une approche neuropsychologique
Marczewski, Philippe; Van der Linden, Martial ULg; Collette, Fabienne ULg et al

in Confrontations Psychiatriques (2000), 41

Memory in not a unified system. It's composed of independant but interacting systems. Cognitive neuropsychology showed dissociations between these systems in patients with various brain lesions. The ... [more ▼]

Memory in not a unified system. It's composed of independant but interacting systems. Cognitive neuropsychology showed dissociations between these systems in patients with various brain lesions. The episodic memory system is devoted to the processing of personally lieved events. The predominant role played by frontal regions in underlying episodic memory has been fully documented. Moreover, the episodic memory disfunctions may lead to illusions of memory such as false memories, confabulations or hallucinations. [less ▲]

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See detailLocalization of Nadph-Protochlorophyllide Reductase in Plastids of Barley at Different Greening Stages
Barthelemy, X.; Bouvier, G.; Radunz, A. et al

in Photosynthesis Research (2000), 64(1), 63-76

The localization of protochorophyllide (Pchlide) and of NADPH-protochlorophyllide oxidoreductase (POR, EC 1.6.99.1) within (etio)chloroplasts has been investigated at selected stages of greening of barley ... [more ▼]

The localization of protochorophyllide (Pchlide) and of NADPH-protochlorophyllide oxidoreductase (POR, EC 1.6.99.1) within (etio)chloroplasts has been investigated at selected stages of greening of barley seedlings. Pchlide pigment and POR protein contents were evaluated in different plastid membrane fractions by fluorescence spectroscopy and immunoblot analysis using a monospecific polyclonal antibody raised against the purified enzyme. Fluorescence analysis showed the presence of Pchlide in both the envelope and thylakoid membranes. During greening, the Pchlide content, expressed on a total protein basis, decreased in thylakoid membranes, whereas it increased in the envelope membranes. POR proteins were detected mainly in thylakoid membranes at early greening stages. In contrast, the weak amount of POR proteins was associated more specifically with envelope membranes of mature chloroplasts. Whatever the greening stage, thylakoid-bound Pchlide and POR proteins were more abundant in the thylakoid regions which remained unsolubilized after mild Triton treatment used as standard procedure to prepare PS II particles. This suggests the preferential association of Pchlide and POR to the appressed regions of thylakoids. [less ▲]

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See detailA novel messenger ribonucleic acid homologous to human MAGE-D is strongly expressed in rat Sertoli cells and weakly in Leydig cells and is regulated by follitropin, lutropin, and prolactin.
Hennuy, Benoît ULg; Reiter, E.; Cornet, Anne ULg et al

in Endocrinology (2000), 141(10), 3821-31

We have cloned a novel complementary DNA whose expression was decreased in rat Sertoli cell cultures after treatment with FSH. This complementary DNA encodes a protein of 570 amino acids and shares 92 ... [more ▼]

We have cloned a novel complementary DNA whose expression was decreased in rat Sertoli cell cultures after treatment with FSH. This complementary DNA encodes a protein of 570 amino acids and shares 92% homology with the human MAGE-D protein. In contrast to other MAGE genes (A, B, or C), we have shown that MAGE-D expression was ubiquitous in healthy rat tissues. In the seminiferous tubules, the MAGE-D was expressed in Sertoli cells but not in germ cells as demonstrated by RT-PCR and in situ hybridization, whereas for the other MAGE genes, expression has been shown to be restricted to germ cells. Interestingly, MAGE-D was also detected for the first time in the female gonad by Northern blotting. In MLTC-1 cells (mouse Leydig tumor cell line-1), LH and PRL stimulated MAGE-D expression. Using hypophysectomized rats, it was confirmed that FSH decreased MAGE-D expression, whereas LH and PRL increased MAGE-D messenger RNA level in the whole testis most probably through a direct action on Leydig cells. As MAGE-D is present in both the seminiferous compartment and interstitium and hormonally regulated in each, it is possible that it has specific functions in each compartment during the development and the maintenance of the testis. [less ▲]

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See detailComment j'explore ... les anomalies du metabolisme glucidique, de l'insulinosecretion et de la sensibilite a l'insuline avec une hyperglycemie provoquee par voie orale.
Luyckx, Françoise ULg; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 881-5

Oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes, impaired glucose tolerance or reactive hypoglycaemia. Simultaneous measurements of ... [more ▼]

Oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes, impaired glucose tolerance or reactive hypoglycaemia. Simultaneous measurements of plasma glucose and insulin levels also allow to derive indices of insulin secretion and insulin sensitivity. Whereas OGTT is not considered anymore as the first choice for the diagnosis of diabetes mellitus, it remains useful for studying abnormalities of glucose metabolism as well as of insulin secretion and insulin action. [less ▲]

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See detailHarcèlement moral au travail. Etat des lieux et pistes de développement.
Faulx, Daniel ULg; Geuzaine, Caroline

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2000), 37(3), 135-147

Revue théorique critique et analyse de littérature sur le harcèlement moral

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See detailLa prescription de l'action publique
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2000)

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See detailLa géométrie de la spatiocarte : corrections et validations, Spatiocartographie
Cornélis, Bernard; Billen, Roland ULg

in Bulletin de la Société Géographique de Liège (2000), (38(1)), 25-43

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See detailGeometric quantities associated to differential operators
Mathonet, Pierre ULg

in Communications in Algebra (2000), 28(2), 699-718

Denote by F_lambda the space of fields of tensor densities of weight -lambda over a manifold M. The space D^p_{lambda,mu} of differential operators of order at most p that map F_lambda onto F_mu are ... [more ▼]

Denote by F_lambda the space of fields of tensor densities of weight -lambda over a manifold M. The space D^p_{lambda,mu} of differential operators of order at most p that map F_lambda onto F_mu are modules over the Lie algebra of vector fields Vect(M). We compute all the Vect(M)-invariant mappings from D^p_{lambda,mu} onto F_nu. [less ▲]

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See detailDes indicateurs européens de qualité de l'éducation : les langues étrangères : un premier exercice
Blondin, Christiane ULg; Demeuse, Marc ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 161-169

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See detailLa rédaction cartographique des spatiocartes
Donnay, Jean-Paul ULg; Cornélis, Bernard

in Bulletin de la Société Géographique de Liège (2000), 38

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See detailMechanics of the Respiratory System in Healthy Newborn Calves Using Impulse Oscillometry
Uystepruyst, Christophe; Reinhold, Petra; Coghe, Joost et al

in Research in Veterinary Science (2000), 68(1), 47-55

Arterial blood gases, acid-base balance and respiratory function tests using impulse oscillometry (IOS) were performed on 40 clinically healthy newborn calves during the first 24 hours of life to evaluate ... [more ▼]

Arterial blood gases, acid-base balance and respiratory function tests using impulse oscillometry (IOS) were performed on 40 clinically healthy newborn calves during the first 24 hours of life to evaluate their respiratory adaptation to extrauterine life. Gas exchange efficiency of the lung was significantly improved with time and was accompanied by the correction of the mixed acidosis observed at birth and by significant changes in respiratory mechanics. Major changes were detected within the first 6 hours. The significant decrease in resistance (R) and the increase in reactance (X) with time, demonstrate the improvement in respiratory mechanics of both upper and lower airways, and reflect the increase in lung volume, the improved lung tissue elasticity and/or distribution of the ventilation. Respiratory mechanical, arterial blood gases and acid-base balance data provided in this study describe a successful respiratory adaptation to extrauterine life in healthy newborn calves. [less ▲]

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See detailNatural case of bovine herpesvirus 1 meningoencephalitis in an adult cow.
Roels, S.; Charlier, G.; Letellier, C. et al

in Veterinary Record : Journal of the British Veterinary Association (2000), 146(20), 586-8

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See detailSkin Tensile Strength Modulation by Compressive Garments in Burn Patients. A Pilot Study
Fournier, R.; Pierard, Gérald ULg

in Journal of Medical Engineering & Technology (2000), 24(6, Nov-Dec), 277-80

Compression therapy is frequently used to prevent hypertrophy of post-burn scars. This pilot study was performed in 6 patients to assess non-invasive changes induced in the tensile strength of the skin ... [more ▼]

Compression therapy is frequently used to prevent hypertrophy of post-burn scars. This pilot study was performed in 6 patients to assess non-invasive changes induced in the tensile strength of the skin before any clinical improvement can be perceived. Assessments were performed using a computerized suction device delivering three 5 s cycles of 500 mbar depression. Measurements were made at one-month intervals for three months after initiating the garment compression therapy. Comparisons were made between the intact skin, the ungrafted and grafted post-burn scars and the graft donor sites. Data show that garment compression therapy alters the tensile strength in the skin of all test sites. The most reliable variations consist of an increase in both the extensibility and elasticity of the tissues submitted to traction. [less ▲]

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See detailEffects of Ephedrine on the Onset Time of Neuromuscular Block and Intubating Conditions after Cisatracurium: Preliminary Results
Albert, Franz ULg; Hans, Pol ULg; Bitar, Yasser et al

in Acta Anaesthesiologica Belgica (2000), 51(3), 167-71

We studied the effects of intravenous ephedrine on the onset time and the intubating conditions 2 min after a bolus dose of cisatracurium (0.15 mg kg-1). Thirty patients anaesthetized with sufentanil and ... [more ▼]

We studied the effects of intravenous ephedrine on the onset time and the intubating conditions 2 min after a bolus dose of cisatracurium (0.15 mg kg-1). Thirty patients anaesthetized with sufentanil and propofol were randomly divided in 2 groups to receive either ephedrine (70 micrograms.kg-1) or saline, 5 s before propofol. Cisatracurium was administered after loss of consciousness. Neuromuscular block was assessed at the adductor pollicis using accelography. Tracheal intubation was performed 2 min after cisatracurium injection and rated as excellent, good, poor or bad. At intubation, neuromuscular block (% height of control T1) was greater in patients receiving ephedrine (36.1 +/- 25.8% vs 57.9 +/- 25.1%) (mean +/- SD). The frequency of excellent intubating conditions was higher after ephedrine (86.6%) than after saline (40.0%). The onset time of cisatracurium was shorter after ephedrine (167 +/- 64.8 s vs 234.9 +/- 63.1 s). Thus, a low dose of ephedrine given before induction of anaesthesia improves the intubating conditions 2 min after 0.15 mg kg-1 cisatracurium and this effect likely relates to a quicker onset of neuromuscular block. [less ▲]

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See detailPathophysiology of a fall in arterial oxygen saturation during sputum induction.
Cataldo, Didier ULg

in CHEST (2000), 117(6), 1818-9

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See detailVitamines anti-oxydantes dans la prevention des maladies cardio-vasculaires. 1ere partie: Le point sur les etudes epidemiologiques.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(1), 11-8

The hypothesis of the atherogenic role of oxidized. LDL lipoproteins and the observation of the longevity of individuals on a "mediterranean diet" led to the concept that antioxidant vitamins may exert ... [more ▼]

The hypothesis of the atherogenic role of oxidized. LDL lipoproteins and the observation of the longevity of individuals on a "mediterranean diet" led to the concept that antioxidant vitamins may exert cardiovascular protective effects. In this first article, we summarize the results of the main epidemiological studies which analyzed the influence of dietary intakes (or resulting plasma concentrations) in vitamin E (alpha-tocopherol), vitamin A (beta-carotene) or vitamin C (ascorbic acid). The three types of studies available in the literature provided quite heterogeneous results, in favour of a protective role of antioxidant vitamins as far as cross-cultural and most prospective observational studies were concerned, but rather negative when considering case-control studies. However, in general, epidemiological studies tended to support, a beneficial role of these antioxidant vitamins to prevent cardiovascular diseases, at least in some subgroups of individuals. [less ▲]

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See detailDu chêne au tonneau
Jourez, Benoît ULg; Quin, Jean-Philippe

in Courrier du Bois (2000), 129

La tonnellerie, activité à la fois artisanale et industrielle, tire profit des plus beaux chênes. Si le mode de fabrication traditionnel du tonneau n'a pratiquement pas changé depuis son invention par les ... [more ▼]

La tonnellerie, activité à la fois artisanale et industrielle, tire profit des plus beaux chênes. Si le mode de fabrication traditionnel du tonneau n'a pratiquement pas changé depuis son invention par les Celtes il y a plus de 2000 ans, certains développements technologiques sont venus aider les artisans dans leur travail quotidien. Parallèlement, le progrès des connaissances dans les sciences du bois, de la chimie et de la microbiologie nous ont appris à quel point l'élevage du vin en fûts de chêne reste une étape essentielle dans la maturation de ce liquide sacré. [less ▲]

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See detailMri Guided Percutaneous Abdominal Biopsy in a Closed Magnet: Assessment in an Animal Study
Fanchamps, J. M.; Kos, X.; Snaps, Frédéric ULg et al

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2000), 83(4), 149-52

MRI guided percutaneous abdominal biopsy was evaluated in an animal model, using a closed magnet and different types of needles. Thirty-six single pass biopsies were performed in 6 piglets with 6 types of ... [more ▼]

MRI guided percutaneous abdominal biopsy was evaluated in an animal model, using a closed magnet and different types of needles. Thirty-six single pass biopsies were performed in 6 piglets with 6 types of MR compatible needles. Virtual targets of a diameter of 2 cm were drawn on the images of the right and left lobe of the liver and the upper and lower poles of both kidneys. FMPSPGR sequences were applied during an apnea of 19 to 23 seconds in axial, sagittal, coronal or axial oblique planes using a closed 1.0 T magnet and the body coil. Piglets were autopsied 1 hour after the procedure. Mean duration of the procedure was 16.9 (11-37) minutes; mean number of acquisitions per procedure was 5.9 (3-12); mean number of redirections of the needle was 0.6 (0-4). Pathological samples from the liver and kidneys of good quality were obtained in 22/36 (72.2%) cases. A subcapsular hematoma was observed in 18/24 (75.0%) cases of renal biopsies and in 1/12 (8.3%) of hepatic biopsies. No statistically significant correlation could be established between duration of the procedure and site of biopsy and between the type of biopsy needle and complication (p = 0.18 to 0.85). In conclusion, MRI guided percutaneous needle biopsy in the abdomen is a reliable technique in piglets using a closed magnet. [less ▲]

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See detailVery Low Surfactant Protein C Contents in Newborn Belgian White and Blue Calves with Respiratory Distress Syndrome
Danlois, F.; Zaltash, S.; Johansson, J. et al

in Biochemical Journal (2000), 351(Pt 3), 779-87

We have studied a respiratory distress syndrome (RDS) occurring in newborn calves of the Belgian White and Blue (BWB) breed that represents the large majority of beef cattle in Belgium. Pulmonary ... [more ▼]

We have studied a respiratory distress syndrome (RDS) occurring in newborn calves of the Belgian White and Blue (BWB) breed that represents the large majority of beef cattle in Belgium. Pulmonary surfactant isolated from 14 BWB newborn calves that died from RDS and from 7 healthy controls was analysed for composition and surface activity. An extremely low content or, in some instances, an absence of surfactant protein C (SP-C) was detected in the RDS samples by Western blotting and differential amino acid analysis [0.03+/-0.01% (w/w) relative to total phospholipids, compared with 0.39+/-0.06% for healthy controls (means+/-S.E.M., P < 0.001)]. The contents of surfactant protein B (SP-B) were similar in RDS and control samples. The crude surfactant samples isolated from RDS calves had higher ratios of total protein to total phospholipid, altered phospholipid profiles and lower SP-A contents. Both crude and organic extracts of RDS surfactant samples showed increased dynamic surface tension compared with healthy controls when evaluated with a pulsating-bubble surfactometer. The addition of purified SP-C to organic extracts of RDS surfactant samples lowered surface tension. Strongly decreased levels of mature SP-C associated with fatal RDS and altered surface activity in vitro have, to the best of our knowledge, not been previously reported. The mechanisms underlying RDS and the decrease in SP-C in BWB calves remain to be established. [less ▲]

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See detailSynovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not
Ribbens, Clio ULg; Andre, Béatrice ULg; Kaye, O. et al

in Rheumatology (2000), 39(12), 1357-1365

OBJECTIVE: To study the levels of matrix metalloproteinase-3 (MMP-3) in the knee synovial fluid (SF) of inflammatory arthropathies (rheumatoid arthritis whether erosive or not, reactive arthritis, acute ... [more ▼]

OBJECTIVE: To study the levels of matrix metalloproteinase-3 (MMP-3) in the knee synovial fluid (SF) of inflammatory arthropathies (rheumatoid arthritis whether erosive or not, reactive arthritis, acute crystal arthritis) and degenerative arthropathies [chronic crystal disease, osteoarthritis and (control) meniscus pathology] and to correlate them with the degree of joint destruction, local inflammatory and immune parameters and systemic markers of inflammation. METHODS: SF levels of MMP-3 (precursor, active and tissue inhibitor of MMP-bound forms), tumour necrosis factor (TNF) alpha, soluble TNF receptors I and II, interleukin (IL)-6 and soluble IL-6 receptor were measured by ELISA in 107 inflammatory and 53 degenerative arthropathies. RESULTS: MMP-3 levels in SF were (i) significantly higher in inflammatory than in degenerative arthropathies; (ii) not related to the degree of joint destruction; (iii) significantly correlated with the levels of all SF markers tested and with erythrocyte sedimentation rate and serum levels of C-reactive protein and fibrinogen. CONCLUSION: Increased MMP-3 levels in SF are found in inflammatory arthropathies and are not specific for erosive joint diseases. MMP-3 in SF is therefore a potential candidate for the assessment of the inflammatory process in joints. However, the exclusive determination of the active form could indicate the degree of joint destruction. [less ▲]

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See detailRelationship between the drift of macroinvertebrates and the activity of brown trout in a small stream
Giroux, F.; Ovidio, Michaël ULg; Philippart, Jean-Claude ULg et al

in Journal of Fish Biology (2000), 56(5), 1248-1257

Brown trout Saline trutta were most active in a small stream at night. dusk and dawn when drift rate was highest, but correlations between hourly drift rates and the trout's activity varied substantially ... [more ▼]

Brown trout Saline trutta were most active in a small stream at night. dusk and dawn when drift rate was highest, but correlations between hourly drift rates and the trout's activity varied substantially between individuals, between different dates for a single individual, and between different periods of the daily cycle. On some occasions. the trout were responsive to the total drift rate, either at night or during the day, and on others to the largest drifting organisms only (terrestrial organisms, adults of Ephemeroptera, Diptera and Trichoptera). The study supports the idea that trout adapt their activity pattern to the abundance of drifting prey, either as generalists towards any organism, or as specialists towards the largest ones. (C) 2000 The Fisheries Society of the British Isles. [less ▲]

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See detailEndocardite végétante dans l’espèce équine : revue de littérature à partir de 2 cas cliniques
Amory, Hélène ULg; Christmann, U.; Cassart, Dominique ULg et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailThe bushlike radiation of muroid rodents is exemplified by the molecular phylogeny of the LCAT nuclear gene.
Michaux, Johan ULg; Catzeflis, F.

in Molecular Phylogenetics & Evolution (2000), 17(2), 280-93

Phylogenetic relationships among 40 extant species of rodents, with an emphasis on the taxonomic sampling of Muridae and Dipodidae, were studied using sequences of the nuclear protein-coding gene LCAT ... [more ▼]

Phylogenetic relationships among 40 extant species of rodents, with an emphasis on the taxonomic sampling of Muridae and Dipodidae, were studied using sequences of the nuclear protein-coding gene LCAT (lecithin cholesterol acyl transferase). Analysis of 804 bp from the exonic regions of LCAT confirmed many traditional groupings in and around Muridae. A strong support was found for the families Muridae (represented by 29 species) and Dipodidae (5 species). Compared with Sciuridae, Gliridae, and Caviomorpha, the Dipodidae family appeared the closest relative of Muridae, confirming the suprafamilial Myodonta concept. Within the speciose family Muridae, the first branching leads to the fossorial Spalacinae and semifossorial Rhyzomyinae. The remaining components of Muridae appear as a polytomy from which are issued Sigmodontinae, Calomyscinae, Arvicolinae, Cricetinae, Mystromyinae, Nesomyinae, and some Dendromurinae (Steatomys and Dendromus). This phylogeny is interpreted as the result of a bushlike radiation at the end of the early Miocene, leading to emergence of most living subfamilies. The separation between three additional taxa, Murinae, Gerbillinae, and "Acomyinae" (which comprises the genera Acomys, Deomys, Uranomys, and Lophuromys), has occurred more recently from a common ancestor issued from the main basal radiation. As previously shown by other molecular studies, the vlei rats, Otomyinae, are nested within Old World Murinae. In the same way, the zokors, Myospalacinae, appear strongly nested within the hamsters, Cricetinae. Finally, we propose a sister group relationship between Malagasy Nesomyinae and south African Mystromyinae. [less ▲]

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See detailEducation pour le troisième millénaire : mes craintes, mes espoirs ... pour l’Université
Merenne-Schoumaker, Bernadette ULg

in Education-Formation (2000), (259), 18-19

Courte réflexion sur les défis de l'Université en termes de formation au début du XXIe siécle

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See detailEcological, morphological and allozymic differentiation between diploid and tetraploid knapweeds (Centaurea jacea) from a contact zone in the Belgian Ardennes
Hardy, O. J.; Vanderhoeven, SONIA ULg; De Loose, M. et al

in New Phytologist (2000), 146(2), 281-290

In the northeastern part of Belgium, the Centaurea jacea complex shows extensive morphological variation and is represented by a diploid (2n = 22) and a tetraploid (2n = 44) cytotype. Polysomic ... [more ▼]

In the northeastern part of Belgium, the Centaurea jacea complex shows extensive morphological variation and is represented by a diploid (2n = 22) and a tetraploid (2n = 44) cytotype. Polysomic inheritance of allozyme markers in the tetraploids, suggesting autopolyploidy, is here demonstrated for the first time. In order to test whether the tno cytotypes occupy distinct habitats and possess different gene pools, patterns of allozymic and morphological variation were investigated in relation to ploidy level and site characteristics in 26 populations from the Belgian Ardennes. The two cytotypes showed a parapatric distribution, the diploids occurring at higher elevations (mostly above 500 m) than the tetraploids (mostly below 500 m). Three mixed populations were found near the contact zone of the two cytotypes. Within the mixed populations no triploid plant and no evidence for gene flow between cytotypes were found, despite widely overlapping flowering periods. The two cytotypes can be distinguished on the basis of morphological traits and enzymatic gene pools. The congruence of morphological and allozymic variation with chromosome numbers suggests a secondary contact between the two cytotypes with limited gene flow between them. The origin and persistence of the parapatric distribution are discussed. [less ▲]

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See detail1re campagne de fouille à Chagar Bazar (Syrie)
Tunca, Önhan ULg; McMahon, A.; Baghdo, Abd el-Massih

in Orient-Express 2000/1 (2000)

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See detailTheoretical analysis of a dynamic thermoconvective pattern in a circular container
Dauby, Pierre ULg; Colinet, Pierre; Johnson, Duane

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (2000), 61(3), 2663-2668

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See detailLinear growth and final height after treatment for Cushing's disease in childhood.
LEBRETHON, Marie-Christine ULg; Grossman, A. B.; Afshar, F. et al

in The Journal of clinical endocrinology and metabolism (2000), 85(9), 3262-5

Cushing's disease is associated with growth failure in childhood and adolescence. Growth and final height were analyzed in 10 patients who were cured or in remission after treatment of Cushing's disease ... [more ▼]

Cushing's disease is associated with growth failure in childhood and adolescence. Growth and final height were analyzed in 10 patients who were cured or in remission after treatment of Cushing's disease. Seven males and 3 females, aged 6.8-17.6 yr (bone age, 3.3-15.4 yr), had transsphenoidal surgery, which was combined with pituitary irradiation (4,500 cGy in 25 fractions) in 5 patients. At presentation, 5 patients were prepubertal (males), and 5 were pubertal (2 males and 3 females). The mean height SD score was -2.15 +/-1.26 (range, -0.21 to -4.32) compared with mean target height SD score of -0.43 +/- 0.58. Height velocity in 6 patients was subnormal (0.9-3.8 cm/yr). After treatment, short-term height velocity, over a mean interval of 0.57 yr, in 8 patients not receiving human GH (hGH) therapy, was variable (range, 0.8-7.6 cm/yr). GH stimulation tests (insulin tolerance test/glucagon) in 9 subjects showed peak GH levels of 0.5-20.9 mU/L. Eight were treated with hGH (14 IU/m2 wk), combined in 2 girls and 1 boy with a GnRH analog. After 1 yr of hGH, the mean height SD score had increased from -2.45 +/- 1.0 at initiation of hGH to -2.07 +/- 1.2 (P = 0.01). GH therapy was continued until final height or latest assessment. The mean final height SD score (n = 6) was - 1.24 +/- 1.38, and at the latest assessment the mean height SD score (n = 4) was - 1.52 +/- 1.33. Combining these 2 groups, the mean height so score was -1.36 +/- 1.29. The difference between final or latest height SD score and target height SD score was 0.93 +/- 1.13, i.e. less (P = 0.005) than the difference between height and target height SD score of 1.72 +/- 1.26 at presentation. In conclusion, catch-up and favorable long-term growth was seen after treatment for Cushing's disease. Posttreatment GH deficiency was frequent, and early hGH replacement may have contributed to the encouraging outcome. [less ▲]

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See detailProgress in Arabidopsis genome sequencing and functionnal genomics.
Wambutt, R.; Portetelle, Daniel ULg; Vandenbol, Micheline ULg et al

in Journal of Biotechnology (2000), 78

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See detailLa progression au sein de la narration en égyptien: Éléments d’une grammaire du texte
Winand, Jean ULg

in Bulletin de l’Institut Français d’Archéologie Orientale (2000), (100), 403-435

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See detailNew strategy for the validation of chromatographic bioanalytical methods
Chapuzet, E.; Mercier, N.; Bervoas-Martin, S. et al

in STP Pharma Pratiques (2000), 10(1), 21-38

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See detailLocal and Global Constraints in Finite Element Modeling and the Benefits of Nodal and Edge Elements Coupling
Dular, Patrick ULg

in International Compumag Society Newsletter (2000), 7(2), 4-7

Various constraints can be encountered in partial differential problems. On the one hand, there are local constraints, which locally act on fields. These are usually boundary conditions, fixing components ... [more ▼]

Various constraints can be encountered in partial differential problems. On the one hand, there are local constraints, which locally act on fields. These are usually boundary conditions, fixing components of fields, as well as interface conditions, connecting such components. On the other hand, global behaviors of fields can be constrained, leading to define global constraints. It is the case when vector field fluxes and circulations have to be defined, again in order to be either fixed or connected. A finite element model of a partial differential problem, through weak formulations, then leads to split up the considered constraints in two families, known as essential and natural constraints. This means that some constraints are strongly satisfied while others are only weakly satisfied. It is the aim of this paper to make a survey of local and global constraints encountered in finite element models of electromagnetic systems. It particularly points out the benefits of using both nodal and edge finite elements to achieve their consistent discrete definitions. There are indeed properties that are worth to be kept from the continuous to the discrete level. The constraints are defined in the frame of dual formulations in order to point out their dual, or complementary, natures. Systematic explicit characterizations of constrained function spaces are shown to be quite convenient. [less ▲]

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See detailLégislation et exercice de l'entomologie en Région wallonne
Fagot, Jean ULg; Dethier, Michel ULg

in Notes Fauniques de Gembloux (2000), 41

In Wallonia, a new law is in study to set up a better level of protection for the fauna and the flora, and that, in respect of the european spirit of Nature preservation. On the other hand, a lot of ... [more ▼]

In Wallonia, a new law is in study to set up a better level of protection for the fauna and the flora, and that, in respect of the european spirit of Nature preservation. On the other hand, a lot of territories are raised to different level of protection. The authors enumerate the consequences of the new act and European directives on the practice of the entomology in Wallonia. [less ▲]

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See detailMuḥibb al-dīn al-Ṭabarī (ob. 694/1295). Un auteur mésestimé ?
Bauden, Frédéric ULg

in Annales Islamologiques (2000), XXXIV

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See detailIschaemic Colitis Following Aortoiliac Surgery
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (2000), 100(1), 21-7

Ischaemic colitis following aortoiliac surgery is a feared complication. Its frequency varies from 7% after repair of ruptured abdominal aortic aneurysm (AAA) to 0.6% after bypass for aortoiliac occlusive ... [more ▼]

Ischaemic colitis following aortoiliac surgery is a feared complication. Its frequency varies from 7% after repair of ruptured abdominal aortic aneurysm (AAA) to 0.6% after bypass for aortoiliac occlusive disease (AOD). In order to analyse predisposing factors and outcome of ischaemic colitis, the authors reviewed their clinical experience from 1988 to 1998. It concerns 28 cases (16 ruptured AAA, 7 elective AAA, 5 OAD) of clinically evident colonic ischaemia. This means an incidence of 7% after repair of ruptured AAA, 0.6% after elective AAA repair, and 0.8% after bypass for AOD. Transmural necrosis (grade 3) was observed in 21 patients, grade 2 ischaemia in 5 patients, and grade 1 ischaemia in 2 patients. Fifteen patients with grade 3 ischaemia underwent colectomy (Hartmann's procedure) with a mortality rate of 66%. All non operated grade 3 patients died. Overall, 16 of the 28 patients died at hospital (57% mortality rate). None of the patients with mild (grade 2 or 1) colonic ischaemia died. Profound hypovolaemic shock and inflammatory AAA were the only significant predisposing factors leading to colonic ischaemia. Associated colon revascularization could not avoid the evolution to colon necrosis in four patients. Reimplantation of a patent inferior mesenteric artery or an internal iliac artery was performed in only 4.8% of all aortoiliac reconstructions, and did not influence the development of ischaemic colitis. The authors conclude that a more liberal use of postoperative sigmoidoscopy could allow detecting colonic ischaemia at an earlier stage and reduce ensuing mortality. A reinforced effort to restore or preserve colonic vascularization could lower the incidence of colonic ischaemia following aortoiliac surgery. [less ▲]

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See detailActualité choisie du TIG et de la formation
Dantinne, Michaël ULg; Van Doosselaere, Denis

in Revue de Droit Pénal et de Criminologie (2000), (11),

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See detailSubungual abscess: a new ungual side-effect related to docetaxel therapy
Vanhooteghem, Olivier ULg; Richert, Bertrand ULg; Vindevoghel, A. et al

in British Journal of Dermatology (2000), 143(2), 462-464

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See detailL'influence de l'article 6 de la Convention européenne des droits de l'homme sur la procédure pénale belge
Jacobs, Ann ULg; Berbuto, Sandra

in Revue de Droit International et de Droit Comparé (2000)

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See detailRandomized comparison of intranasal and transdermal estradiol.
Lopes, P.; Merkus, H. M.; Nauman, J. et al

in Obstetrics & Gynecology (2000), 96(6), 906-12

To compare the efficacy and patient acceptability of intranasal versus transdermal 17 beta-estradiol (E2) delivery systems for postmenopausal symptoms. METHODS: Postmenopausal women were randomly assigned ... [more ▼]

To compare the efficacy and patient acceptability of intranasal versus transdermal 17 beta-estradiol (E2) delivery systems for postmenopausal symptoms. METHODS: Postmenopausal women were randomly assigned to intranasal 17 beta-E2, 300 microg daily (n = 176) or transdermal 17 beta-E2 (delivering 50 microg/day), two patches per week (n = 185) for 12 weeks, followed by a 4-week period with the alternate treatment. Efficacy was compared between groups using the Kupperman Index and vasomotor symptoms at week 12. Patient acceptability was compared by patient choice of administration route and by questionnaire at week 16. RESULTS: Intranasal and transdermal therapy produced significant reductions in the Kupperman Index and in the occurrence of hot flushes and night sweats at week 12. Alleviation of climacteric symptoms was statistically equivalent in the two treatment groups (P <.001). The difference between groups in the Kupperman Index score of -0.5 +/- 0.9 (95% confidence interval -2.3, 1.3) was within the predetermined interval of equivalence. Both therapies were well tolerated with similar adverse event rates, except for moderate and severe mastalgia which was significantly less frequent with intranasal E2 (7.2%) than with the patch (15.5%, P =.02). Sixty-six percent of patients chose to continue the intranasal therapy and 34% the transdermal therapy (P <.001). Satisfaction was greater with intranasal therapy at week 16 (P <.001). CONCLUSION: Intranasal and transdermal estrogen delivery systems had equivalent efficacy and similar safety profiles. Intranasal therapy was the patients' choice for long-term treatment. [less ▲]

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See detailLoss of plant organogenic totipotency in the course of in vitro neoplastic progression
Gaspar, Thomas ULg; Kevers, Claire ULg; Bisbis, Badia et al

in In Vitro Cellular & Developmental Biology-Plant (2000), 36(3), 171-181

The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under ... [more ▼]

The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under different circumstances: genetic variation in the cell population, epigenetic changes, disappearance of an organogenesis-promoting substance, etc. The same reasons may be evoked for the progressive and eventually irreversible loss of organogenic totipotency in the course of neoplastic progressions from hormone-independent tumors and hyperhydric teratomas to cancers. As in animal cells, plant cells at the end of a neoplastic progression have probably undergone several independent genetic accidents with cumulative effects. They indeed are characterized by atypical biochemical cycles from which they are apparently unable to escape. The metabolic changes are probably not the primary defects that cause cancer, rather they may allow the cells to survive. How these changes, namely an oxidative stress, affect organogenesis is not known. The literature focuses on somatic mutations and epigenetic changes that cause aberrant regulation of cell cycle genes and their machinery. [less ▲]

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See detail2e campagne de fouille à Chagar Bazar (Syrie)
Tunca, Önhan ULg; McMahon, A.; Baghdo, Abd el-Massih

in Orient-Express 2000/4 (2000)

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See detailDual Formulations for the Modeling of Thin Electromagnetic Shells using Edge Elements
Geuzaine, Christophe ULg; Dular, Patrick ULg; Legros, Willy ULg

in IEEE Transactions on Magnetics (2000), 36(4), 799-803

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See detailEffects of glucocorticoids on hepatic sensitivity to insulin and glucagon in man.
Dirlewanger, M.; Schneiter, P. H.; Paquot, Nicolas ULg et al

in Clinical Nutrition (2000), 19(1), 29-34

AIMS: This study was undertaken to determine the effects of a short-term dexamethasone treatment on hepatic sensitivities to insulin and glucagon. METHODS: Eleven healthy subjects were studied during one ... [more ▼]

AIMS: This study was undertaken to determine the effects of a short-term dexamethasone treatment on hepatic sensitivities to insulin and glucagon. METHODS: Eleven healthy subjects were studied during one or several of four protocols. In all protocols, somatostatin was infused continuously to inhibit pancreatic hormone secretion. In protocol 1, basal insulin was infused over 300 min while glucagon was infused at a rate of 0.5 mg/kg(-1)/min(-1)during 180 min, then at a rate of 1.5 ng/kg(-1)/min(-1)during 150 min. In protocol 2, the same experiment was performed after a 2 day treatment with 8 mg/day dexamethasone. In protocol 3, the two-step glucagon infusion was performed during insulin infusion at a rate aimed to reproduce the hyperinsulinemia observed during protocol 2. In protocol 4, continuous basal insulin and low glucagon (0.5 mg/kg(-1)/min(-1)) were infused over 330 min. RESULTS: In protocol 1, plasma glucose rose transiently by 2.0 +/- 0.3 mmol/l when the glucagon rate was increased and glucose production increased by 1.4 +/- 0.5 micromol/kg(-1)/min(-1). In protocol 2, the insulin infusion rate (1.85 +/- 0.36 nmol/kg(-1)/min(-1)) required to maintain glycemia was 3.3-fold higher than during protocol 1. Glucagon-induced stimulation of glycemia (by 1.47 +/- 0.5 mmol/l) and endogenous glucose production (by 0.8 +/- 0.3 micromol/kg(-1)/min(-1)) were blunted, but not abolished. In protocol 3, endogenous glucose production was suppressed by 75% by hyperinsulinemia and was not stimulated when the glucagon infusion rate was increased. In protocol 4, endogenous glucose production did not change significantly with time. CONCLUSION: These results indicate that high dose glucocorticoids induce a marked hepatic insulin resistance. Stimulation of glucose production by hyperglucagonemia was maintained in spite of hyperinsulinemia which can be attributed to either hepatic insulin resistance and/or increased hepatic glucagon sensitivity. [less ▲]

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See detailBooklist 1999
Pirenne, Christophe ULg

in Popular Music (2000), 19(3), 403-434

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See detailComment évaluer le raisonnement géométrique ?
Jehin, Monique ULg; Chenu, Florent ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 67-85

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See detailAlteration of thyroid hormones, insulin-like growth factor-I (IGF-I) and IGFBPs in finishing calves treated with dexamethasone
Bertozzi, Carlo; Massart, Serge; Darras, Veerle et al

in Canadian Journal of Animal Science (2000), 80

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See detailGenetic Determinants Of Bovine Leukemia Virus Pathogenesis
Willems, Luc ULg; Burny, A.; Collete, Delphine et al

in Aids Research and Human Retroviruses (2000), 16(16), 1787-95

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been ... [more ▼]

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep. [less ▲]

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See detailOppositions locales et dynamiques d'environnementalisation
Mormont, Marc ULg; Bertrand, Anne

in Espaces et Sociétés (Paris, France) (2000), (101-102), 93-112

Local conflicts provoke collective action that through new coalitions induce reformulations of the problems and elarge scope and scaling of environmental problems. These processes are called ecologization ... [more ▼]

Local conflicts provoke collective action that through new coalitions induce reformulations of the problems and elarge scope and scaling of environmental problems. These processes are called ecologization dynamics and are going to transform environmental politics. [less ▲]

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See detailCharacteristics of the iron moment in Dy-Fe and Dy-FeCo amorphous alloys studied by X-ray magnetic circular dichroism
Fleury-Frenette, Karl ULg; Dhesi, S. S.; van der Laan, G. et al

in Journal of Magnetism & Magnetic Materials (2000), 220(1), 45-51

The local magnetic moment of Fe in Dy-Fe and Dy-FeCo amorphous alloys has been studied using X-ray absorption spectroscopy and X-ray magnetic circular dichroism (XMCD). The Fe orbital and spin magnetic ... [more ▼]

The local magnetic moment of Fe in Dy-Fe and Dy-FeCo amorphous alloys has been studied using X-ray absorption spectroscopy and X-ray magnetic circular dichroism (XMCD). The Fe orbital and spin magnetic moments have been obtained for a range of alloy compositions by applying the sum rules to the XMCD spectra. The room temperature variations of the average components of the Fe moments as a function of Dy concentration and with the substitution of Fe by Co have been determined. A sharp reversal of the total magnetic moment was found at 28 +/- 1 at% Dy for both alloys. (C) 2000 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailComment j'explore...une mycobactériose cutanée atypique
Henry, Frédérique ULg; Hayette, Marie-Pierre ULg; Melin, Pierrette ULg et al

in Revue Médicale de Liège (2000), 55(12), 1058-1063

Atypical mycobacteriosis affecting the skin are diverse and their treatments are different as well. These diseases show an increasing prevalence. The contamination occurs from the environment while ... [more ▼]

Atypical mycobacteriosis affecting the skin are diverse and their treatments are different as well. These diseases show an increasing prevalence. The contamination occurs from the environment while interhuman transmission does not occur. [less ▲]

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See detailIncreased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies
Ribbens, Clio ULg; Andre, Béatrice ULg; Kaye, O. et al

in European Cytokine Network (2000), 11(4), 669-676

The assessment of cytokines and their soluble receptors in the synovial fluid (SF) of inflammatory arthropathies may be useful in studying pathogenetic and immunoregulatory mechanisms underlying different ... [more ▼]

The assessment of cytokines and their soluble receptors in the synovial fluid (SF) of inflammatory arthropathies may be useful in studying pathogenetic and immunoregulatory mechanisms underlying different diseases. The aim of this work was to study the cytokine network occurring in inflammatory arthropathies and to identify a cytokine profile which is characteristic of an immune-mediated synovitis. Levels of IL-12, as well as IL-4, IL-8, IL-10, IFN-gamma, sCD25, TNF-alpha and its soluble receptors were measured in the SF of various arthropathies, i.e. non-inflammatory arthropathies: "control" meniscus pathology (n = 21), osteoarthritis (n = 22) and chronic crystal arthritis (n = 9); a non-immune inflammatory arthropathy: acute crystal arthritis (n = 11); 2 immune inflammatory arthropathies: reactive arthritis (ReA) (n = 23) and rheumatoid arthritis (RA) (n = 44). SF levels of IL-10, TNF-alpha and sTNF-RII were found to be increased in the three inflammatory arthropathies compared to the "control" meniscus group. Within the inflammatory group, acute crystal arthritis was characterized by a significantly higher sTNF-RI/TNF-alpha ratio and ReA by a significantly lower sTNF-RII/TNF-alpha ratio compared to the two other diseases. The two immune arthropathies, RA and ReA, were characterized by increased SF levels of IL-12, sCD25 and of the sTNF-RII/sTNF-RI ratio. ReA differed however from RA by showing lower IL-8 and IL-4 levels, higher IFN-gamma levels and a higher IL-12/IL-10 ratio, suggesting a more prevalent Th1 profile in ReA SF. Our data indicate that the measurement of SF cytokines and soluble receptors may discriminate between each inflammatory arthropathy and might be useful in clinical practice. [less ▲]

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See detailÀ la recherche de l'«art public» dans les villes de la Mésopotamie
Tunca, Önhan ULg

in Art&Fact (2000), 19

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See detail“E andè drétt u n s va invéll”: Percorsi di Raffaello Baldini
Benzoni, Pietro ULg

in Studi novecenteschi (2000), XXVII(59), 7-57

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See detailQuantitative bacterial cultures and cytological examination of bronchoalveolar lavage specimens in the diagnosis of lower respiratory tract disease in dogs: a retrospective study of 48 cases.
Peeters, Dominique ULg; McKierman, B.; Weisiger, R. et al

in Journal of Veterinary Internal Medicine (2000), 14(5), 534-541

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective ... [more ▼]

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective study was conducted to determine the usefulness of quantitative aerobic cultures and Gram stain intracellular bacteria counts from bronchoalveolar lavage (BAL) specimens in dogs in diagnosing lower respiratory tract infection (LRTI) and to determine whether chronic bronchitis is associated with marked bacterial growth in dogs. The threshold determined to define clinically relevant bacterial growth was 1.7 x 10(3) colony-forming units per milliliter of BAL fluid. We used this threshold and found that diagnostic sensitivity and specificity were 86% and 100%, respectively. With a threshold for infection of >2 intracellular bacteria observed in any of 50 fields, microscopic examination of Gram stain BAL preparations had a sensitivity of 71% and a specificity of 97% in establishing LRTI. There was a high correlation between bacterial morphology on BAL Gram stain and bacterial cultures. Combining the results of intracellular bacteria counts from the BAL Gram stain with those from the quantitative cultures, the sensitivity in diagnosing LRTI was 87% and the specificity was 97%. BAL quantitative cultures as well as quantitating intracellular bacteria on Gram stain BAL cytology were revealed to be useful in identifying LRTI in dogs. Chronic bronchitis does not appear to be associated with marked bacterial growth in dogs. [less ▲]

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See detailBiocompatibility of polyethylene glycols (PEG): An approach using bovine serum albumin (BSA) as a protein model.
Loret, S; Gilson, P; Barakat, I et al

in Pflügers Archiv : European Journal of Physiology (2000), 440

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See detailGelling properties of whey proteins after enzymic fat hydrolysis
Blecker, Christophe ULg; Paquot, Michel ULg; Deroanne, C.

in Journal of Food Science (2000), 65(4), 561-563

The effect of residual fat hydrolysis upon the gelation of whey protein concentrate (WPC) was studied. Gelling properties of a commercial WPC and lipase-treated WPC were evaluated on the basis of least ... [more ▼]

The effect of residual fat hydrolysis upon the gelation of whey protein concentrate (WPC) was studied. Gelling properties of a commercial WPC and lipase-treated WPC were evaluated on the basis of least concentration endpoint gelation, penetration test, texture profile analysis and water-holding capacity. Heat treatment of lipase-treated WPC led to gels with the highest hardness, springiness, cohesiveness and water retention. Such transformed WPC could be advantageously used to help improve texture in formulated meat, bakery, and confectionery products. [less ▲]

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See detailTechnique for a rapid and efficient purification of the SHV-1 and PSE-2 beta-lactamases.
Bouillenne, Fabrice ULg; Matagne, André ULg; Joris, Bernard ULg et al

in Journal of Chromatography. B : Biomedical Sciences and Applications (2000), 737(1-2), 261-5

A simple procedure is described which results in an optimised resolution in molecular sieve chromatography. A sample exhibiting a large initial volume (about 20 ml) and conditioned in a buffer of low ... [more ▼]

A simple procedure is described which results in an optimised resolution in molecular sieve chromatography. A sample exhibiting a large initial volume (about 20 ml) and conditioned in a buffer of low ionic strength (<20 mM) by filtration through a 53-ml G25 molecular sieve column, is adsorbed on a 1.7-ml ion-exchange (SOURCE) column. The proteins are released by a 10-ml pulse of 1 M NaCl and the eluate directly injected onto a 120-ml Sephacryl S100-HR column. The very low volume of the eluate ensures optimal conditions and resolution for the molecular sieving process. The method is applied as the polishing step in the purification of the SHV-1 and PSE-2 beta-lactamases. It could easily be scaled up for the treatment of larger samples. [less ▲]

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See detailExtensions des techniques de reparation valvulaire mitrale: chirurgie de l'endocardite et des tumeurs valvulaires
Radermecker, M. A.; Gach, Olivier ULg; Henrottaux, G. et al

in Revue Médicale de Liège (2000), 55(10), 950-3

Mitral valve repair has demonstrated its superiority over valve replacement. Mitral valve repair constitutes the optimal therapeutic option in case of degenerative dystrophic, rheumatic, congenital or ... [more ▼]

Mitral valve repair has demonstrated its superiority over valve replacement. Mitral valve repair constitutes the optimal therapeutic option in case of degenerative dystrophic, rheumatic, congenital or ischemic mitral valve disease. These surgical techniques can also be successfully and advantageously applied in case of bacterial endocarditis or tumoral valvular disease. We report a case of staphylococcal endocarditis and another case of posterior leaflet fibroelastoma to show the place of conservative mitral surgery in these unusual indications. [less ▲]

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See detailIdentification de cultivars de palmier dattier (Phoenix dactylifera L.) par l'amplification aléatoire d'ADN (RAPD)
Ben Abdallah, Abdallah; Stiti, Kadija; Du Jardin, Patrick ULg et al

in Cahiers Agricultures (2000), 9(2), 103-107

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See detailEclipse totale du 11 août 1999 et évolution de la basse ionosphère
Delcourt, J. J.; Jodogne, J.-C.; Biémont, Emile ULg

in Ciel et Terre (2000), 116(1), 6-7

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See detailLong-Term Protection Against Bovine Leukaemia Virus Replication In Cattle And Sheep
Kerkhofs, P.; GATOT, Jean-Stéphane ULg; Knapen, K. et al

in Journal of General Virology (2000), 81

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See detailSome influences of sediments in aerated lagoons and waste stabilization ponds
Chabir, D.; El Ouarghi, H.; Brostaux, Yves ULg et al

in Water Science & Technology (2000), 42(10), 237-246

Respirometric tests have been undertaken on sediments in aerated lagoons and waste stabilization ponds to quantify their oxygen demand and to determine the main factors governing the process. Factors such ... [more ▼]

Respirometric tests have been undertaken on sediments in aerated lagoons and waste stabilization ponds to quantify their oxygen demand and to determine the main factors governing the process. Factors such as seasonal variations, temperature, substrate, sediment layer thickness, density of macro-invertebrates and suspended sediments were investigated. The results showed that temperature and substrate concentration are the main factors that influence sediment oxygen demand; followed by spatial heterogeneity and resuspension of sediments, whereas the density of macro-invertebrates could have an effect in summer (hot season). Sediment layer thickness had no effect. A model of sediment oxygen demand is developed for the two main factors (temperature and substrate) with an r2 of 0.98. [less ▲]

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See detailMass Transfer Across an Interface Induces Formation of Droplets in Lattice Systems
Pfennig, Andreas ULg

in Chemical Engineering Science (2000), 55(22), 5333-5339

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See detailEvidence-based medicine. Apport des essais cliniques controles.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(4), 216-9

Controlled clinical trials are the support of Evidence-Based Medicine. In most instances, only them can indeed provide the demonstration of both the efficacy and safety of a pharmacological treatment ... [more ▼]

Controlled clinical trials are the support of Evidence-Based Medicine. In most instances, only them can indeed provide the demonstration of both the efficacy and safety of a pharmacological treatment, based upon rigorous scientific experimental observations avoiding potential bias due to subjective interpretation. In order to be able to extrapolate conclusions of drug trials to clinical practice and to positively influence physician's attitudes, "explanatory" trials, which aim at proving the intrinsic activity of the molecule, should be completed by "pragmatic" trials, which aim at demonstrating the clinical utility of the drug. [less ▲]

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See detailL'image du mois. Thrombose de la veine porte
Ancion, G.; Delwaide, Jean ULg; Boverie, Jacques ULg

in Revue Médicale de Liège (2000), 55(8), 761-762

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See detailDo estrogens effectively prevent osteoporosis-related fractures?
Reginster, Jean-Yves ULg; Bruyère, Olivier ULg; Audan, M. et al

in Calcified Tissue International (2000), 67

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See detailTable of Ap and Am Stars in order of Variable-star Names II
Renson, Pierre ULg

in A Peculiar Newsletter (2000), 33

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See detailResource Trading Agents for Adaptive Active Network Applications
Yamamoto, Lidia; Leduc, Guy ULg

in Networking and Information Systems Journal (2000), 3(4-5), 743-768

Adaptive applications seem to be the only realistic answer to the increasing diversity and decentralisation in networks. In order to accommodate fluctuations in network conditions, adaptive applications ... [more ▼]

Adaptive applications seem to be the only realistic answer to the increasing diversity and decentralisation in networks. In order to accommodate fluctuations in network conditions, adaptive applications need to obtain information about resource availability. Using mobile agent technology applied to active networks, new models for adaptive applications can be envisaged. In this article we review the state of the art in agent and active network techniques for adaptive applications, and describe our work on an agent model for trading resources inside an active network node. We apply the model to the case of an audio mixing application. Our simulation results indicate that the model allows the application to make efficient use of the available resources, and to share resources according to user preferences. [less ▲]

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See detailConvenient Genotyping of Six Myostatin Mutations Causing Double-Muscling in Cattle Using a Multiplex Oligonucleotide Ligation Assay
Karim, Latifa ULg; Coppieters, Wouter ULg; Grobet, Luc ULg et al

in Animal Genetics (2000), 31(6), 396-9

We herein describe a procedure that allows for simultaneous genotyping of six loss-of-function mutations in the bovine myostatin gene associated with the double-muscling phenotype. The proposed method ... [more ▼]

We herein describe a procedure that allows for simultaneous genotyping of six loss-of-function mutations in the bovine myostatin gene associated with the double-muscling phenotype. The proposed method relies on a multiplex oligonucleotide ligation assay and detection of the fluorescently labelled products using automatic sequencers. [less ▲]

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See detailEffective treatment of Jo-1-associated polymyositis with T-cell-depleted autologous peripheral blood stem cell transplantation.
Baron, Frédéric ULg; Ribbens, Clio ULg; Kaye, O. et al

in British Journal of Haematology (2000), 110(2), 339-342

A patient with Jo-1 antibody-associated polymyositis (Jo-1 PM) had a Karnofsky score of 40% and severe muscle, liver and lung damage that was refractory to standard therapy. The female patient received an ... [more ▼]

A patient with Jo-1 antibody-associated polymyositis (Jo-1 PM) had a Karnofsky score of 40% and severe muscle, liver and lung damage that was refractory to standard therapy. The female patient received an autologous T-cell-depleted haematopoietic stem cell transplant (HSCT) after myeloablative conditioning. The transplant procedure was complicated by severe adult respiratory distress syndrome (ARDS) and adenovirus-associated haemorrhagic cystitis as well as cytomegalovirus (CMV) reactivation. The patient's creatinine phosphokinase (CPK) and alanine transaminase (ALT) values were normal on day 21. The patient's strength has improved remarkably and her dyspnoea is subjectively improved. At 15 months after the transplant, the patient was well with a Karnofsky score of 80% and had been off any therapy, including steroids, for 14 months. [less ▲]

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See detailRelative Accuracy of the Identification of Ovarian Structures in the Cow by Ultrasonography and Palpation Per Rectum
Hanzen, Christian ULg; Pieterse, M.; Szenci, Otto et al

in Veterinary Journal (2000), 159(2), 161-170

Manual palpation or ultrasonographic examination of the cow's genital tract are currently used by veterinarians involved in reproductive management, but knowledge of the potential and the limitations of ... [more ▼]

Manual palpation or ultrasonographic examination of the cow's genital tract are currently used by veterinarians involved in reproductive management, but knowledge of the potential and the limitations of both methods is important to obtain an optimal accuracy in the diagnosis of physiological and pathological ovarian structures. This review presents the main features of manual and ultrasonographic characteristics of follicles, corpora lutea (with or without a cavity), follicular and lutenized cysts and the reliability of the two methods is compared. Manual diagnosis of follicles <10 mm is rather inaccurate, but ultrasound offers the possibility to diagnose follicles <5 mm and to measure their inner diameter. The predictive values of the presence or absence of a corpus luteum as determined by palpation are similar (78 vs. 75%). Manual or ultrasonographic diagnosis of the growing or regressing corpus luteum is rather difficult. The positive predictive value of a mature corpus luteum diagnosed by ultrasonography is lower (87%) than the negative predictive value (92%). Compared to manual palpation, ultrasonography permits a better estimation of the number and to determine more precisely the size of the mature corpus luteum. The positive values for follicular cysts diagnosed by palpation or by ultrasonography are 66 and 74% respectively, and for luteal cysts, the values are 66 and 85%, respectively. Manual palpation or ultrasonography are useful tools to diagnose ovarian structures in the cow. The accuracy of such methods can be enhanced by securing information on the reproductive history of the animal, palpation of uterine horns, vaginal examination or progesterone determinations. [less ▲]

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See detailIncreased synovial fluid levels of soluble CD23 are associated with an erosive status in rheumatoid arthritis (RA).
Ribbens, Clio ULg; Bonnet, V.; Kaiser, Marie-Joëlle ULg et al

in Clinical & Experimental Immunology (2000), 120(1), 194-199

Synovial fluid (SF) levels of soluble CD23 (sCD23) were determined in 96 patients presenting with an inflammatory knee effusion (73 with RA and 23 with reactive arthritis (ReA) serving as a control ... [more ▼]

Synovial fluid (SF) levels of soluble CD23 (sCD23) were determined in 96 patients presenting with an inflammatory knee effusion (73 with RA and 23 with reactive arthritis (ReA) serving as a control inflammatory non-erosive group) and were correlated with the degree of joint destruction, with local immune parameters (IL-1beta, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12 and sCD25) and with serum markers of inflammation, C-reactive protein and erythrocyte sedimentation rate. RA patients, classified as erosive or not according to Larsen's grade, were separated as follows: (i) 13 patients with non-erosive RA; (ii) 16 RA patients with erosions in hands but not in knees, matched for disease duration with the first group; (iii) 44 RA patients with hand and knee erosions, matched with the second group for rheumatoid factor positivity but of longer disease duration. SF sCD23 levels were significantly increased in both erosive RA groups compared with non-erosive diseases, whether RA or ReA (P < 0.05), whose SF levels were not different. SF IL-10 showed a similar profile to that of SF sCD23 and was the only other parameter characteristic of erosive RA, but no direct correlation was found between the two. SF sCD23 was significantly correlated with IL-12 (r = 0.65, P = 0.0001) and sCD25 (r = 0.39, P = 0.0019) exclusively in the two erosive RA populations. In conclusion, these data showing that increased levels of sCD23 are not only found in the SF of erosive joints but also in knee SF of patients with erosive RA but without knee x-ray-diagnosed erosions suggest that this parameter might be of predictive value for joint destruction. Longitudinal studies are however needed to confirm its potential clinical interest. [less ▲]

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See detailNerve biopsy: indications and contribution to the diagnosis of peripheral neuropathy. The experience of the Born Bunge Foundation University of Antwerp and University of Liege between 1987 and 1997.
Deprez, Manuel ULg; Ceuterick-de Groote, C.; Schoenen, Jean ULg et al

in Acta Neurologica Belgica (2000), 100(3), 162-6

We reviewed 355 nerve biopsies analysed at the Laboratories of Neuropathology of the Born-Bunge Foundation/University of Antwerp (BBF/UIA) and University of Liege (ULg) between 1987 and 1997. We examined ... [more ▼]

We reviewed 355 nerve biopsies analysed at the Laboratories of Neuropathology of the Born-Bunge Foundation/University of Antwerp (BBF/UIA) and University of Liege (ULg) between 1987 and 1997. We examined the indications for nerve biopsy, the yield of the procedure, and the influence of clinical and neuropathological parameters. Contributory biopsies accounted for 35.5% and 47.3% respectively at ULg and BBF/UIA laboratories: of these, one third showed specific histological findings, the majority being informative only when combined with the relevant clinical data. The profile of indications for nerve biopsy was roughly comparable in both laboratories. The search for an inflammatory neuropathy prompted 35-40% of all biopsies with more than 50% of specimens being informative in this indication. The lowest yield (20%) was obtained among the nerve biopsies performed in the absence of any presumptive aetiology. These accounted for 22-33% of all cases. Inadequate surgical resection, delays in transport or processing errors precluded histological study of 4% (BBF/UIA) to 8% (ULg) of the specimens. We conclude that nerve biopsies should be performed by experienced surgeons and handled in specialised laboratories. Only a relatively small number of causes of neuropathy can be diagnosed on the basis of histology alone. More often, contributory biopsies will result from the combination of non-specific suggestive histological features with relevant clinical information. The diagnostic yield of nerve biopsy is function of careful patient selection and close collaboration between the clinician and the neuropathologist. [less ▲]

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