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Le médicament du mois. Le benzamycin, une actualisation du traitement topique de l'acnéPierard, Gérald in Revue Médicale de Liège (1997), 52(2), 120-2Detailed reference viewed: 17 (0 ULg) Comment je traite ... un melasma du visagePierard, Gérald in Revue Médicale de Liège (1997), 52(2), 58-9Detailed reference viewed: 7 (0 ULg) Localization of Laminin, Fibronectin, E-Cadherin, and Integrins in Endometrium and EndometriosisBeliard, Aude ; Donnez, J.; Nisolle, Michelle et alin Fertility and Sterility (1997), 67(2), 266-72OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study ... [more ▼]OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study. SETTING: University Hospital, Department of Gynecology and Department of Cell Biology. PATIENT(s): Eighteen endometriosis patients undergoing laparoscopy for pain or infertility and nine control patients undergoing laparoscopy for sterilization or hysterectomy. MAIN OUTCOME MEASURE(s): The expression of adhesion glycoproteins (laminin and fibronectin), their receptors alpha 1 beta 1, alpha 2 beta 1, alpha 3 beta 1, alpha 5 beta 1, and alpha 6 beta 1, and E-cadherin was determined by immunohistochemistry on frozen sections. RESULT(s): The distribution of both adhesive glycoproteins, laminin and fibronectin, and their receptors was identical in endometriosis and endometrium. Fibronectin receptors (alpha 4 beta 1, alpha 5 beta 1) displayed distinct expression patterns in endometrium and endometriosis. No endometrial glands showed positive staining for the alpha 5 chain, whereas this integrin subunit was detected in almost all endometriotic lesions. The integrin alpha 4 chain was present in all endometriotic glands but was absent from endometrial glands in the proliferative phase of the cycle. CONCLUSION(s): No difference in cell adhesion molecule localization nor receptors was observed between endometriotic and endometrial samples, except for fibronectin receptors. Their expression persisted around endometriotic glands but not in endometrium. These results suggest that fibronectin receptors could play a role in the persistence of endometriotic lesions, despite menstruation in corresponding eutopic endometrium. [less ▲]Detailed reference viewed: 35 (5 ULg) Clinical Neurophysiology of HeadacheSchoenen, Jean in Neurologic Clinics (1997), 15(1), 85-105Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches ... [more ▼]Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches. They are traumatic, able to explore simple or more complex neural activities, and to some extent capable of reflecting activity in certain neurotransmitter systems as well as the action of pharmacologic agents on the CNS. This article reviews the interest and limits of electroencephalography, evoked potentials, electromyography, and nocifensive reflexes in primary headaches. Because neurophysiologic methods are no more than indirect means of looking into the "black box," their results need to be interpreted with caution and, whenever possible, should be compared in the same study with clinical behavioral and biochemical data. [less ▲]Detailed reference viewed: 19 (0 ULg) Peyer's Patches in Murine Aids: Dissociation between Lymphoproliferation and AnergyColombi, S.; Moutschen, Michel ; de Leval, Laurence et alin Scandinavian Journal of Immunology (1997), 45(2), 175-81RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches ... [more ▼]RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches (PP). To understand the cellular interactions underlying lymphoproliferation further, the authors investigated the fate of PP in RadLV-Rs infected mice. The atrophy of PP was mostly due to the depletion of B cells, while the proportion of CD4+ and CD8+ T cells was increased. Nevertheless, B cell phenotype was modified with the emergence of lymphocytes with a low expression of B220 in infected PP. T cells characterized by a memory/activated phenotype in control PP did not undergo phenotypical changes after viral infection (i.e. regarding Thy-1 and CD44 expression). Despite the absence of lymphoproliferation, PP T and B cells displayed altered responses to mitogens in vitro. Finally, alterations of the expression of adhesion molecules and vascular addressins could not explain the atrophy of PP by a reduced homing to this lymphoid site. B cells and T cells from normal PP are clearly different from lymph nodes (LN) lymphocytes. The authors propose that the particular functional state which characterizes PP lymphocytes influences the B cell/T cell crosstalk necessary for RadLV-Rs-induced lymphoproliferation. [less ▲]Detailed reference viewed: 5 (0 ULg) Anionic polymerization of primary acrylates as promoted by Lithium 2-(2-Methoxyethoxy) ethoxideNugay, Nihan; Nugay, Turgut; Jérôme, Robert et alin Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(2), 361-369Some primary acrylates, such as methyl, ethyl, n-butyl, and n-nonyl acrylate (MA, EA, nBuA and nNonA, respectively) have been anionically polymerized by using diphenylmethyl lithium (DPMLi) as an ... [more ▼]Some primary acrylates, such as methyl, ethyl, n-butyl, and n-nonyl acrylate (MA, EA, nBuA and nNonA, respectively) have been anionically polymerized by using diphenylmethyl lithium (DPMLi) as an initiator, in the presence of a chelating - dual ligand, i.e., a polydentate lithium alkoxide, at low temperature. It has been found that lithium 2-(2-methoxyethoxy) ethoxide (LiOEEM) is a very efficient ligand in preventing the anionic polymerization of these monomers from being disturbed by significant secondary transfer and termination reactions. Even for the difficult cases of ethyl and methylacrylate, that approach provides high polymerization yields and low polydispersity, allowing the molecular weight to be predetermined. LiOEEM/initiator molar ratio, solvent polarity, temperature and monomer concentration have proved to be key parameters in the control of the polymerization process. The efficiency of that control is however dependent on the monomer structure and improves with the length of the n-alkyl substituent, i.e., MA < EA < nBuA < nNonA. [less ▲]Detailed reference viewed: 33 (2 ULg) Synthesis and characterization of biodegradable homopolymers and block copolymers based on adipic anhydrideRopson, Nathalie; Dubois, Philippe ; Jérôme, Robert et alin Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(1), 183-192Homopolymers of adipic anhydride (AA) and block copolymers of -caprolactone (-CL) and AA have been synthesized with aluminum triisopropoxide as an initiator. Homopolymerization was studied at 20°C in ... [more ▼]Homopolymers of adipic anhydride (AA) and block copolymers of -caprolactone (-CL) and AA have been synthesized with aluminum triisopropoxide as an initiator. Homopolymerization was studied at 20°C in toluene and methylene chloride (CH2Cl2). The end-group analysis agrees with a coordination insertion mechanism based on the acyl-oxygen cleavage of the AA ring. Living poly(-caprolactone) (PCL) chains are very efficient macro-initiators for the polymerization of AA, with formation of diblock copolymers of a narrow molecular weight distribution. At our best knowledge, low molecular weight -aluminum alkoxide PCL macroinitiators (M¯n < 1000) allow the first valuable synthesis of PAA with a molecular weight as high as 58,000 and a quite narrow polydispersity (M¯w/M¯n = 1.2). Size-exclusion chromatography (SEC) and 13C NMR confirm the blocky structure of the copolymers, in agreement with DSC that shows two melting endotherms and two glass transitions characteristic of the crystalline and amorphous phases of PCL and PAA, respectively. Block copolymers of c-CL and AA are also sensitive to hydrolysis, which makes them possible candidates for biomedical applications. Initiation of the AA polymerization in bulk with aluminum triisopropoxide in the presence of various ligands is also discussed. [less ▲]Detailed reference viewed: 13 (6 ULg) Living Anionic Homopolymerization and Block Copolymerization of (Dimethylamino)ethyl MethacrylateCreutz, Serge; Teyssié, Philippe; Jérôme, Robert in Macromolecules (1997), 30(1), 6-9Anionic polymerization of (dimethylamino)ethyl methacrylate (DMAEMA) has been investigated in THF at -78°C. The presence of lithium chloride has been shown to be desirable in order to afford a narrow ... [more ▼]Anionic polymerization of (dimethylamino)ethyl methacrylate (DMAEMA) has been investigated in THF at -78°C. The presence of lithium chloride has been shown to be desirable in order to afford a narrow molecular weight distribution as well as a good agreement between theoretical and observed molecular weight. The living character of the polymerization has been demonstrated. Thus the synthesis of block copolymers, some of them unattainable by GTP, has been carried out successfully. Finally, the anionic polymerization of mixtures of tert-butyl methacrylate (tBMA) and DMAEMA has been considered and their relative reactivity ratio estimated. The easy quaternization of (dimethylamino)ethyl methacrylate affords amphiphilic water-soluble copolymers displaying interesting characteristics as polymeric dispersants and surfactants. [less ▲]Detailed reference viewed: 19 (2 ULg) Living Anionic Homopolymerization and Block Copolymerization of 4-Vinylpyridine at "Elevated" Temperature and Its Characterization by Size Exclusion ChromatographyCreutz, Serge; Teyssié, Philippe; Jérôme, Robert in Macromolecules (1997), 30(1), 1-5The anionic polymerization of 4-vinylpyridine (4VP) has been investigated in 9/1 pyridine/THF at 0 °C. After characterization of the living character of 4VP polymerization, its copolymerization with tert ... [more ▼]The anionic polymerization of 4-vinylpyridine (4VP) has been investigated in 9/1 pyridine/THF at 0 °C. After characterization of the living character of 4VP polymerization, its copolymerization with tert-butyl methacrylate (tBMA) has been carried out also successfully. Their relative reactivity ratios have been determined. Solvent composition as well as temperature have been varied in order to evaluate their influence on the final molecular characteristics of the polymers. Finally, a new SEC methodology in 8/1/1 N,N-dimethylformamide/triethylamine/pyridine has been developed. [less ▲]Detailed reference viewed: 13 (1 ULg) Different universality classes for SOC in models driven by extremal dynamicsVandewalle, Nicolas ; Ausloos, Marcel in Europhysics Letters [=EPL] (1997), 37(1), 1-6We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree ... [more ▼]We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree-like model does not seem to belong to any already studied SOC universality class. This is shown through a discussion of the dynamics and the so-called gap equation which does not hold here. [less ▲]Detailed reference viewed: 10 (1 ULg) Fourth supplement to the catalogue of observed periods of Ap starsCatalano, F. A.; Renson, Pierre in Astronomy and Astrophysics. Supplement Series (1997), 121New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before ... [more ▼]New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before but it was not reported in previous issues of this catalogue. For many stars also present in previous issues of the catalogue new determinations of the periods are given. Recently attributed variable star names are also quoted. Table 1, notes to this Table and related references are only available in LaTEX form at the CDS via anonymous ftp 130.79.128.5 (filename: DS1178.tex). [less ▲]Detailed reference viewed: 7 (1 ULg) An updated model of the hot nitrogen atom kinetics and thermospheric nitric oxideGérard, Jean-Claude ; Bisikalo, D. V.; Shematovich, V. I. et alin Journal of Geophysical Research (1997), 102New observations and reanalysis of previous measurements suggest an upward revision of the measured thermospheric nitric oxide density. Our previous model of NO production by fast N([SUP]4[/SUP]S) atom ... [more ▼]New observations and reanalysis of previous measurements suggest an upward revision of the measured thermospheric nitric oxide density. Our previous model of NO production by fast N([SUP]4[/SUP]S) atom collisions with O[SUB]2[/SUB] has been updated. It includes the effect of soft solar X rays, Auger electrons, and a detailed treatment of N[SUB]2[/SUB] dissociative ionization channels. In addition, new calculations indicate that the transfer of translational energy in N+N[SUB]2[/SUB] collisions is less efficient than in the hard sphere approximation. This result leads to reevaluation of the energy dependent relaxation cross section and to an upward revision of the reacting efficiency of collisions of N with O[SUB]2[/SUB] to form nitric oxide. The calculated peak NO density increases by a factor of ~2 when the effect of superthermal nitrogen atoms is included. The model response of the N([SUP]4[/SUP]S) energy distribution function and NO density to solar cycle variations is presented. The NO density at 110 km changes from 5.4×10[SUP]7[/SUP] to 1.3×10[SUP]8[/SUP]cm[SUP]-3[/SUP] when the solar F[SUB]10.7[/SUB] index varies from 70 to 245, but its response depends on the magnitude of the soft X ray increase with solar activity. [less ▲]Detailed reference viewed: 18 (0 ULg) Triblock copolymer based thermoreversible gels. 1. Self-association of sPMMA end-blocks in o-xylene and viscoelasticity of the gelsYu, Jian Ming; Jérôme, Robert ; Teyssié, Philippein Polymer (1997), 38(2), 347-354Syndiotactic poly(methyl methacrylate) (sPMMA)-polybutadiene (PBD)-sPMMA triblock copolymers, or MBM, have been studied in the presence of o-xylene which is a selective solvent for the central PBD block ... [more ▼]Syndiotactic poly(methyl methacrylate) (sPMMA)-polybutadiene (PBD)-sPMMA triblock copolymers, or MBM, have been studied in the presence of o-xylene which is a selective solvent for the central PBD block. Syndiotactic PMMA is known to self associate in o-xylene. The central PBD sequence does not prevent the self-association of sPMMA from occurring. Actually, this phenomenon contributes to the stability of the gels formed at room temperature. An endotherm is observed at 35°C, which is responsible for a gel-sol transition. The original solutions have been heated up to 80°C and then rapidly cooled down below 35°C and maintained at 10, 20 and 25°C respectively. The self-association of the sPMMA outer blocks, and thus the liquid-solid transition, have been studied at each of these temperatures. Dependence of the gel viscosity on frequency and temperature effects on viscoelasticity has also been investigated. [less ▲]Detailed reference viewed: 46 (2 ULg) Elevated Plasma Alpha 1-Acid Glycoprotein Levels: Lack of Connection to Resistance to Vecuronium Blockade Induced by Anticonvulsant TherapyHans, Pol ; Brichant, Jean-François ; Pieron, F. et alin Journal of Neurosurgical Anesthesiology (1997), 9(1), 3-7This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled ... [more ▼]This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled for routine neurosurgery were included in the study. The patients were treated (TG; n = 20) with phenytoin (n = 15) and/or carbamazepine (n = 4) and/or phenobarbital (n = 3) for > or = 6 days or were left untreated (UG; n = 11, control group). TG patients were further assigned to one of two subgroups according to the plasma anticonvulsant level measured the day before surgery and found to be within (TGW, n = 10) or below (TGB, n = 10) the therapeutic range. Finally, the 31 patients were divided into two more groups according to their plasma AAG levels: higher than (HAAG, n = 17) or within (NAAG, n = 14) the normal range (25-94 mg dl-1). Anesthesia was induced and maintained with propofol and sufentanil. Muscle relaxation was obtained with vecuronium 0.1 mg kg-1. A train-of-four (TOF) stimulation mode at 2 Hz was applied to the ulnar nerve every 15 s, and neuromuscular transmission was assessed using a TOF-Guard accelograph monitor. Plasma AAG concentrations (means +/- SEM) were 103.7 +/- 7.6 mg dl-1 in TG, 80.7 +/- 6.7 mg dl-1 in UG, 95.9 +/- 13.2 mg dl-1 in TGW, 111.6 +/- 7.6 mg dl-1 in TGB. 114.9 +/- 7.4 mg dl-1 in HAAG, and 71.4 +/- 3.8 mg dl-1 in NAAG groups. The differences in plasma AAG concentrations between UG and TG and between HAAG and NAAG groups were statistically significant. No significant relationship was found between plasma AAG levels and phenytoin concentrations (r = -0.26). The time (mean +/- SEM) to recovery of T1 to 25% of control was significantly shorter in TG (28.2 +/- 1.4 min) than in UG (42.2 +/- 3.1 min) but did not differ significantly according to the plasma anticonvulsant level (27.3 +/- 2.0 min in TGW; 29.1 +/- 1.9 min in TGB) and the plasma AAG level 31.7 +/- 1.9 min in HAAG; 35.3 +/- 3.3 min in NAAG). The time for the TOF ratio to recover to 25% yielded similar profiles and statistical significance levels: TG, 32.9 +/- 2.2 min; UG, 51.2 +/- 4.0 min; TGW, 35.0 +/- 3.9 min; TGB, 30.7 +/- 1.8 min; HAAG, 38.1 +/- 3.1 min; NAAG, 42.0 +/- 4.1 min. We conclude that anticonvulsant therapy induces an increase in plasma AAG independently of the plasma anticonvulsant level. However, duration and recovery of vecuronium blockade do not differ according to plasma AAG levels. Consequently, elevated AAG does not contribute to the resistance to vecuronium blockade induced by anticonvulsants. [less ▲]Detailed reference viewed: 41 (5 ULg) Increase in Cytokine Production (Il-1 Beta, Il-6, Tnf-Alpha but Not Ifn-Gamma, Gm-Csf or Lif) by Stimulated Whole Blood Cells in Postmenopausal OsteoporosisZheng, S. X.; Vrindts-Gevaert, Yvonne; Lopez, Marie-Josée et alin Maturitas (1997), 26(1), 63-71Postmenopausal osteoporosis is a progressive disorder characterized by a decreased bone mass and increased susceptibility to fractures. Several investigations have suggested that one of the mechanisms ... [more ▼]Postmenopausal osteoporosis is a progressive disorder characterized by a decreased bone mass and increased susceptibility to fractures. Several investigations have suggested that one of the mechanisms through which estrogen prevents bone loss was a modulation on secretion or release of various cytokines that are known to influence bone remodeling, even if some recent data have challenged this hypothesis. However, in established osteoporosis, the possibility that enhanced cytokines activity may account for the progression of this disease remains unclear and controversial. We sought here to determine whether production of IL-1 beta, IL-6, TNF-alpha, IFN-gamma, GM-CSF and LIF, after direct stimulation in whole blood, was different in healthy (n = 30) or osteoporotic postmenopausal women (n = 24) and whether lumbar bone density (1-BMD) correlated with the values of cytokine production observed in these conditions. A significant difference was observed between the osteoporotic and control subjects for IL-1 beta (p < 0.0001), IL-6 (p < 0.001) and TNF-alpha (p = 0.027) productions, the values being higher in the osteoporotic women. No significant differences between the groups were observed for IFN-gamma (p = 0.51), GM-CSF (p = 0.70) or LIF (p = 0.97). In the whole population, statistically significant negative correlations were observed between lumbar BMD and IL-1 beta (r = -0.46) (p < 0.0005), IL-6 (r = -0.50) (p < 0.0001) and TNF-alpha (r = -0.39) (p < 0.005) production while no such correlations were observed for IFN-gamma, GM-CSF or LIF. In conclusion, the study of cytokine production by immune cells cultured in autologous whole blood suggests that in women more than 10 years past the menopause and presenting a decrease in lumbar bone density corresponding to the new WHO definition of "osteoporosis', production of IL-1 beta, IL-6 and TNF-alpha is still increased compared to controls matched for age and ovarian function, while no differences are reported for IFN-gamma, GM-CSF or LIF production. [less ▲]Detailed reference viewed: 58 (6 ULg) Analysis of Equine Scintigraphical Lung ImagesVotion, Dominique ; Vandenput, Sandrina ; Duvivier, H. et alin Veterinary Journal (1997), 153(1), 49-61A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to ... [more ▼]A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to establish reference ranges of I/Q distribution pattern. Computed I/Q images were divided in three regions based on the activity due to the inhalation (I) versus perfusion (Q) procedure. For each region a regional mismatching factor (Iri), i.e. the I/Q of the region, and an intraregional mismatching factor (Lri), which expresses the variability of pixels' I/Q within the region, were calculated. The Per(Ri) and Cen(Ri), which are the percentage of pixels in the parenchymal and in the central parts of the lung belonging to the region, were also computed. Results of this analysis showed a good match between I and Q distribution pattern. [less ▲]Detailed reference viewed: 30 (9 ULg) Accident vasculaire cérébral et thrombus aortique chez un patient déficient en protéine SLambermont, Bernard ; Ghuysen, Alexandre ; Marcelle, Roland et alin Archives des Maladies du Coeur et des Vaisseaux (1997), 90(1), 99-102The authors report the case of a 50 year old man admitted to hospital with a right hemiplegia and aphasia of sudden onset in whom embolic fragments were found in the left mid and anterior cerebral artery ... [more ▼]The authors report the case of a 50 year old man admitted to hospital with a right hemiplegia and aphasia of sudden onset in whom embolic fragments were found in the left mid and anterior cerebral artery territories at left carotid angiography : transoesophageal echocardiography demonstrated a protrusive plaque of atherosclerosis in the ascending aorta and a pediculated thrombosis in the descending aorta. Biological investigations revealed a protein S level of 3% (normal : 70-140%). This case illustrates the acute development of a thromboembolic phenomenon originating from the aortic arch in a patient with a coagulation defect. [less ▲]Detailed reference viewed: 50 (9 ULg) Construction and properties of fractal trees with tunable dimension: The interplay of geometry and physicsVandewalle, Nicolas ; Ausloos, Marcel in Physical Review E (1997), 55(1), 94-98In this paper, we emphasize three different techniques for the growth of fractal trees with a desired fractal dimension D-f. The three different growths are due to the influence of (i) stretched branches ... [more ▼]In this paper, we emphasize three different techniques for the growth of fractal trees with a desired fractal dimension D-f. The three different growths are due to the influence of (i) stretched branches, (ii) dead ends, or (iii) a variable branching rate. Several examples are given. We point out that geometrical and physical properties (skeleton dimension, percolation exponents, self-avoiding walk) of fractal tress depend strongly on their type. The most striking result is that the critical exponents at the percolation transition are nonuniversal since they depend on the tree type. The critical exponents depend on D-f for trees of types (ii) and (iii). [less ▲]Detailed reference viewed: 40 (0 ULg) Cytotoxic interactions of 5-fluorouracil and nucleoside analogues in vitroLi, Y-X; COUCKE, Philippe ; Paschoud, N et alin Anticancer Research (1997), 17(1A), 21-27The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3 ... [more ▼]The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3'-deoxy-2', 3'-didehydrothymidine (D4T), 5-iododeoxyuridine (IdUrd) and 2',3'-dideoxycytidine (DDC) were tested at different concentrations (5-600 microM) as modulators of 5-FU. The experimental endpoints were cellular viability and cell cycle distribution. The combination of 5-FU and AZT or D4T yielded supra-additive cytotoxic effects in both cell lines at all concentrations. On WiDr, IdUrd at high concentrations of 50 and 100 microM showed a supra-additive effect whereas at low concentrations (5, 10 and 20 microM) the effect was antagonistic. 5-FU combined with IdUrd produced a synergistic effect on MCF-7 cells at all concentrations. DDC antagonised the toxic effect of 5-FU on the WiDr cell line. In WiDr cells, a significant increase in the overall S-phase was observed 48 and 72 hours after exposure to D4T, AZT and DDC at the low concentration of 10 microM. On the contrary, this accumulation in S-phase was not present in MCF-7 cells. The combined effect of 5-FU and nucleoside analogues in vitro is dependent on the type and concentration of nucleosides and the cell-line tested. AZT, D4T and IdUrd are more likely to be subjected to more intensive in vitro and in vivo research as far as modulation of 5-FU toxicity is concerned. [less ▲]Detailed reference viewed: 6 (0 ULg) Les Banyarwanda du Sud-Kivu: les Banyamulenge?Kabamba, Bob in Revue Nouvelle (1997), (n°1), 7-15Detailed reference viewed: 93 (7 ULg) Stereotaxic Needle-Core Biopsy and Fine-Needle Aspiration Biopsy in the Diagnosis of Nonpalpable Breast Lesions: Controversies and Future ProspectsLifrange, Eric ; Kridelka, Frédéric ; Colin, Claude in European Journal of Radiology (1997), 24(1), 39-47OBJECTIVE: To determine the advantages and limitations of a combined stereotaxic fine-needle aspiration biopsy and needle-core biopsy in the diagnosis of 353 nonpalpable breast lesions with special ... [more ▼]OBJECTIVE: To determine the advantages and limitations of a combined stereotaxic fine-needle aspiration biopsy and needle-core biopsy in the diagnosis of 353 nonpalpable breast lesions with special attention given to the collection of follow-up data. METHODS AND MATERIAL: 353 nonpalpable breast lesions underwent 'one pass' stereotaxic fine-needle aspiration (21 gauge needle) and needle-core biopsy (18 gauge needle) at our institution from January 1990 to October 1993. Stereotaxic biopsies were carried out by means of an 'add-on unit'. Surgical biopsy was usually recommended for highly suspicious radiologic patterns and/or needle biopsy reports classified as atypical or malignant. In all other cases mammographic follow-up was advised at 6 months and then annually for 3 years. The data were collected retrospectively during September 1995 (theoretical average follow-up of greater than 3 years). RESULTS: Following the combined needle biopsy technique procedure, surgery was recommended for 83 lesions. Fifty-four cancers were associated to these suspicious lesions. Because of changing radiological or clinical pattern during follow-up (mean follow-up: 22 months), 11 cancers were detected among the 270 lesions initially considered not to need surgery. Forty-three percent of the 65 malignant lesions were initially read as having less than highly suspicious mammographic features. There was no significant difference between the sensitivity and the specificity of one pass fine-needle aspiration biopsy (57% and 96% respectively) and needle-core biopsy (60% and 97% respectively), but noncontributive samples were not included in the false negative diagnoses and atypical samples were included in the true positive diagnoses. Of the 11 missed cancers, nine were manifested initially by clusters of calcifications. Our diagnostic approach was significantly less sensitive (P = 0.006) and less specific (P = 0.032) in cases of clusters of calcifications (31% false negative diagnoses) than in cases of soft-tissue masses (5.5% false negative diagnoses). In this study, an average delay in diagnoses of 22 months was responsible for a significantly increased percentage of axillary node positive invasive cancer (P < 0.001) and six of the 11 missed cancers were palpable at the time of the delayed diagnosis. For the nine cancers initially manifested by calcifications, the 22 months delay in diagnosis was responsible for a nonsignificant increase of microinvasive type at the expense of carcinoma in situ. CONCLUSION: Our enthusiasm with the sensitivity of this double stereotaxic needle sampling has been tempered by the results of this reanalysis in the light of a mean theoretical follow-up of three years. Our diagnostic approach was adequate in the presence of soft-tissue masses but not valid in the presence of clustered calcifications. When dealing with calcifications, multiple samplings must be done in order to improve the sensitivity of the diagnosis. Furthermore, this study does not favour the theory that the majority of mammographically detected cancers are indolent and highlights the poor sensitivity of the mammographic follow-up of nonpalpable lesions. [less ▲]Detailed reference viewed: 21 (4 ULg) Expression of Bone Matrix Proteins in Human Breast Cancer: Potential Roles in Microcalcification Formation and in the Genesis of Bone MetastasesBellahcene, Akeila ; Castronovo, Vincenzo in Bulletin du Cancer (1997), 84(1), 17-24The skeleton is the privileged target of metastatic human breast cancer cells. Bone metastases are indeed found in virtually all advanced breast cancer patients and generate major morbidity. The high ... [more ▼]The skeleton is the privileged target of metastatic human breast cancer cells. Bone metastases are indeed found in virtually all advanced breast cancer patients and generate major morbidity. The high osteotropism of breast cancer cells suggests that they exhibit a selective affinity for mineralized tissues. The observation that mammary malignant cells are able to induce hydroxyapatite crystals deposition within the primary tumour suggests that they can generate a microenvironment that favors the crystallization of calcium and phosphate ions into the bone specific hydroxyapatite. Osteonectin (OSN), osteopontin (OPN) and bone sialoprotein (BSP), 3 bone matrix proteins involved in bone matrix mineralization, are expressed in human breast cancers. BSP, an RGD (Arg-Gly-Asp) containing phosphoprotein, initiates hydroxyapatite deposition and mediates attachment of osteoclast to the same crystals prior to their resorption. Detection of BSP at both the protein and the mRNA levels in human breast cancer and in human breast cancer cell lines (MCF-7, T47-D and MDA-MB 231) indicates that mammary malignant cells synthesize directly BSP rather than uptaking it from the serum. Interestingly, the level of BSP expression correlates with the development of bone metastases and with poor survival. These data suggest that the ectopic expression of bone matrix proteins could be involved in conferring osteotropic properties to circulating metastatic breast cancer cells. These observations open new alleys of investigation for the identification of the molecular mechanisms responsible for the genesis of bone metastases. [less ▲]Detailed reference viewed: 71 (2 ULg) Miscellaneous and Experimental AgentsReginster, Jean-Yves in American Journal of the Medical Sciences (The) (1997), 313(1), 33-40Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally ... [more ▼]Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally demonstrated full prevention of the appearance or the recurrence of axial or peripheral fractures so far, many investigational compounds are being developed. Anabolic steroids act mainly as inhibitors of bone resorption with very few, if any, effects on bone formation. Because of the high occurrence of signs of virilization and the weak effects on bone structure, the risk/benefit ratio in osteoporosis should be considered at least problematic. If ongoing large-scale trials confirm the expected benefits of estrogen antagonist/agonists on the skeleton and confirm no cardiovascular risk to postmenopausal women with optimal uterine safety, these substances are likely to become the most prominent alternative to hormonal replacement therapy after the menopause. Additional studies are requested to evaluate the potential benefit of growth hormone or insulin-like growth factors in treatment of osteoporosis. Ipriflavone acts predominantly as an inhibitor of bone resorption. To confirm the efficacy of ipriflavone on the prevention of vertebral fractures and its effects on bone mineral density in women with postmenopausal established osteoporosis, a large multicentric European study is being conducted. Treatment with parathyroid peptides induces a significant gain in bone mass, mainly in the axial skeleton. Long-term studies that compare peptides, doses, and regimes are needed to better understand the exact position of parathyroid peptides as treatment of osteoporosis. Prolonged administration of strontium to postmenopausal osteoporotic women resulted in a decoupling between bone resorption and formation that yielded a significant increase in the lumbar spine bone mineral density of treated subjects. In the view of these promising results and of the excellent tolerance of strontium during preliminary trials, additional investigations of this compound in prevention and treatment of osteoporosis should be promptly initiated. Several other compounds have been punctually suggested for treatment of osteoporosis or are at very early stages of development. Finally, besides pharmacologic approaches to the treatment of osteoporosis, hip fractures may also be reduced by the use of hip protectors. [less ▲]Detailed reference viewed: 5 (2 ULg) Living free radical polymerization of macromonomers: preparation of well defined graft copolymersHawker, Craig Jon; Mecerreyes, David; Elce, Edmund et alin Macromolecular Chemistry and Physics (1997), 198(1), 155-166Well defined graft copolymers have been synthesized by a nitroxide-mediated "living" free radical process using pre-formed macromonomers. Analysis of the graft systems revealed that the macromonomer was ... [more ▼]Well defined graft copolymers have been synthesized by a nitroxide-mediated "living" free radical process using pre-formed macromonomers. Analysis of the graft systems revealed that the macromonomer was efficiently incorporated into the polymeric back-bone to give block copolymers of controlled molecular weight and narrow polydispersi-ties. An added benefit of the "living" free radical process is that macromonomers, such as polylactide or polycaprolactone, which contain reactive functional groups can be used to form novel graft Systems using this approach. Functionalized monomers or polymeric initiators were also used in the copolymerization mixture to give graft Systems with a variety of functional groups attached to the backbone. [less ▲]Detailed reference viewed: 66 (10 ULg) Malignancy transplantation with graft: do patients with primary central nervous system tumors have to be excluded from the donor pool?Detry, Olivier ; Honoré, Pierre ; Meurisse, Michel et alin Transplant International (1997), 10(1), 83-84Detailed reference viewed: 24 (7 ULg) Streptococcus difficile Is a Nonhemolytic Group B, Type Ib StreptococcusVandamme, Peter; Devriese, L. A.; Pot, B. et alin International Journal of Systematic Bacteriology (1997), 47(1), 81-5Whole-cell protein electrophoretic analysis of the type strain of Streptococcus difficile (LMG 15799) revealed that this organism was indistinguishable from Streptococcus agalactiae strains. Although LMG ... [more ▼]Whole-cell protein electrophoretic analysis of the type strain of Streptococcus difficile (LMG 15799) revealed that this organism was indistinguishable from Streptococcus agalactiae strains. Although LMG 15799'r (T = type strain) was originally described as serologically untypeable, we found that this strain was a group B streptococcus belonging to the capsular polysaccharide antigen type Ib group. The biochemical reactivity of S.difficile, which differed from the biochemical reactivity of typical S. agalactiae strains mainly by being less versatile, is similar to the biochemical reactivity of other group B, type Ib streptococci isolated from poikilothermic animals, such as fish and frogs. [less ▲]Detailed reference viewed: 16 (1 ULg) Geometric and healing laws in simple stochastic models of fracture in a sputtering processDhulst, R.; Vandewalle, Nicolas ; Ausloos, Marcel in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 55(1), 189-193We investigated two simple models of two-dimensional square lattice fracture under sputtering process conditions extending a previously studied model by Ausloos and Kowalski [Phys. Rev. B 45, 12 830 (1992 ... [more ▼]We investigated two simple models of two-dimensional square lattice fracture under sputtering process conditions extending a previously studied model by Ausloos and Kowalski [Phys. Rev. B 45, 12 830 (1992)]. The models differ by the particle displacement rules during the fracture. Healing of the medium is observed in both models. This effect implies the formation of several thresholds during sputtering process fracture. They are distributed as a size-dependent power law. An avalanche like exponent is also obtained. We study this phenomenology within scaling arguments of classical percolation theory and mean-field arguments. [less ▲]Detailed reference viewed: 9 (1 ULg) Calcitonine et vieillissement osseuxReginster, Jean-Yves in Pathologie Biologie (1997), 45(1), 52-6There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that ... [more ▼]There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that dose may also be sufficient to prevent trabecular bone loss and that higher doses (> or = 200 IU/day) induce a significant increase in spinal bone mineral content. Calcium supplements should be systemically administered when calcitonin is given, particularly at high doses. Rectal calcitonin seems also to be an efficient alternative in prevention of trabecular bone loss. Further studies are required to evaluate the effect of calcitonin in prevention of cortical bone loss. In established osteoporosis, calcitonin may prevent further bone loss at trabecular and cortical sites. A similar benefit is obtained following parenteral or nasal administration of the drug. Long-term administration of nasal salmon calcitonin induces a significant dose-dependent gain of bone at the lumbar spine, whereas discontinuous therapy with a ratio of 1:2 or 2:3 between the treatment and nontreatment periods is the best regimen for cortical bone. Epidemiological, retrospective, and prospective studies provide a convergent network of evidence that calcitonin administration in osteoporosis contributes to reduce significantly the frequency of subsequent fractures, both in the spine and in the hip. Finally, in established osteoporosis, nasal calcitonin possesses a potent analgesic effect, reduces the duration of bed confinement, and decreases the number of concomitant analgesic medications. The well-demonstrated effects of nasal calcitonin permit it to be considered as a highly rational solution for the prevention and the treatment of postmenopausal osteoporosis. [less ▲]Detailed reference viewed: 13 (1 ULg) Influence de l'incorporation de mélasse à l'ensilage de maïs sur l'ingestion, la digestibilité apparente, les fermentations dans le rumen et les performances zootechniques chez le taurillon à l'engraissementMayombo, Asangule Pierre; Dufrasne, Isabelle ; Baldwin, Paule et alin Annales de Médecine Vétérinaire (1997), 141Detailed reference viewed: 29 (3 ULg) Feeding of the sparid fish Sarpa salpa in a seagrass ecosystem: Diet and carbon fluxHavelange, S.; Lepoint, Gilles ; Dauby, Patrick et alin Marine Ecology (1997), 18(4), 289-297In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ... [more ▼]In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ratios were measured in fish muscle and potential food sources (algae, P. oceanica leaf and its epiphytes) to determine their relative contribution to the fish diet. S. salpa has an age-related mixed diet: juveniles are plankton feeders, young, sub-adults and adults are herbivorous, and, the older the individuals, the higher the relative contribution of P. oceanica to the diet. Our results and former studies of carbon stocks and fluxes in the P. oceanica bed of Revellata Bay have enabled an estimation of the general impact of S. salpa grazing on infralittoral communities: the studied species consumes 24 g C.m-2.a(-1) from P. oceanica leaf, 4.8 from epiphytes and 13 from epilithic algae. The fish net production and biomass turnover in that zone have been estimated to be 1.2 g C.m(-2).a(-1) and 1.5 a(-1), respectively. [less ▲]Detailed reference viewed: 169 (10 ULg) Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.Kas, K.; Voz, Marianne ; Roijer, E. et alin Nature Genetics (1997), 15(2), 170-4Pleiomorphic adenoma of the salivary glands is a benign epithelial tumour occurring primarily in the major and minor salivary glands. It is by far the most common type of salivary gland tumour ... [more ▼]Pleiomorphic adenoma of the salivary glands is a benign epithelial tumour occurring primarily in the major and minor salivary glands. It is by far the most common type of salivary gland tumour. Microscopically, pleiomorphic adenomas show a marked histological diversity with epithelial, myoepithelial and mesenchymal components in a variety of patterns. In addition to a cytogenetic subgroup with normal karyotypes, pleiomorphic adenomas are characterized by recurrent chromosome rearrangements, particularly reciprocal translocations, with breakpoints at 8q12, 3p21, and 12q13-15, in that order of frequency. The most common abnormality is a reciprocal t(3;8)(p21;q12). We here demonstrate that the t(3;8)(p21;q12) results in promoter swapping between PLAG1, a novel, developmentally regulated zinc finger gene at 8q12, and the constitutively expressed gene for beta-catenin (CTNNB1), a protein interface functioning in the WG/WNT signalling pathway and specification of cell fate during embryogenesis. Fusions occur in the 5'-non-coding regions of both genes, exchanging regulatory control elements while preserving the coding sequences. Due to the t(3;8)(p21;q12), PLAG1 is activated and expression levels of CTNNB1 are reduced. Activation of PLAG1 was also observed in an adenoma with a variant translocation t(8;15)(q12;q14). Our results indicate that PLAG1 activation due to promoter swapping is a crucial event in salivary gland tumourigenesis. [less ▲]Detailed reference viewed: 20 (0 ULg) A one-nucleotide difference in a cAMP and phorbol ester response element leads to differential regulation of the human chorionic somatomammotropin A and B gene transcriptionOury, Cécile ; Alsat, E.; Jacquemin, P. et alin Journal of Molecular Endocrinology (1997), 18(2), 87-99Human chorionic somatomammotropin (hCS) is encoded by two highly related genes, hCS-A and hCS-B, located in the hGH/hCS gene locus. Both genes are expressed in the syncytiotrophoblast layer of the ... [more ▼]Human chorionic somatomammotropin (hCS) is encoded by two highly related genes, hCS-A and hCS-B, located in the hGH/hCS gene locus. Both genes are expressed in the syncytiotrophoblast layer of the placenta and hCS release from trophoblast cells is known to be increased by cAMP and phorbol esters. However, it remains unclear whether this regulation acts at the level of hCS gene expression or secretion and whether both genes are affected. We examined the effects of cAMP and phorbol 12-myristate 13-acetate (PMA) on the transcription of the hCS-A and hCS-B genes. Transient expression experiments revealed a 7 bp cAMP- and PMA-responsive element (CRElhCS-A) spanning nucleotides-1102 to -1096 upstream of the hCS-A gene. In contrast, the homologous sequence upstream of hCS-B (CRElhCS-B), differing from CRElhCS-A by a single substitution, shows little or no response to cAMP. In band-shift assays, the CRElhCS-A oligonucleotide was shown to bind two factors related to CREBP and AP-1, whereas CRElhCS-B only competes for one of these complexes. Finally, Southwestern analysis revealed that the CRElhCS-A element binds two ubiquitous proteins of 100 kDa and 47 kDa respectively, whereas CRElhCS-B interacts only with the 47 kDa protein. Taken together, these results suggest that a 47 kDa protein binding to the CRElhCS-A and CRElhCS-B elements is involved in the PMA response of the hCS-A and hCS-B genes, and a 100 kDa protein plays a crucial role in cAMP regulation of the hCS-A gene. [less ▲]Detailed reference viewed: 29 (5 ULg) Toxicological investigations on four sperm whales stranded on the Belgian coast: inoganic contaminantsBouquegneau, Jean-Marie ; Debacker, Virginie ; Gobert, Sylvie et alin Bulletin de l'Institut Royal des Sciences Naturelles de Belgique. Sciences de la Terre (1997), 67Detailed reference viewed: 17 (3 ULg) On endostyle ultrastructure in two new species of doliolid-like tunicatesCompère, Philippe ; Godeaux, Jean in Marine Biology (1997), 128Detailed reference viewed: 14 (4 ULg) Origine sociale et réussite scolaire : un modèle en Chaîne de Markov estimé sur données individuelles belgesDonni, Olivier; Lejeune, Bernard in Recherches Economiques de Louvain (1997), 63(4), 421-446Cet article étudie les relations entre l'origine socio-économique des élèves belges et leur parcours scolaire primaire et secondaire. Il repose sur l'hypothèse que le parcours scolaire des élèves peut ... [more ▼]Cet article étudie les relations entre l'origine socio-économique des élèves belges et leur parcours scolaire primaire et secondaire. Il repose sur l'hypothèse que le parcours scolaire des élèves peut être décrit par un processus de Markov. Sur la base d'un échantillon transversal d'un millier d'enfants, en fonction de variables socio-économiques et pour chacune des années de scolarité obligatoire, les probabilités individuelles de poursuivre un parcours scolaire ''normal'', c.-à-d. sans redoublement ni relégation dans une filière de second choix, sont estimées. Nos résultats montrent que derrière les substantiels taux agrégés de redoublement qui caractérisent le système scolaire belge se cachent en fait de profondes inégalités sociales. [less ▲]Detailed reference viewed: 331 (10 ULg) Influence of a blend of fructo-oligosaccharides and sugar beet fiber on nutrient digestibility and plasma metabolites concentrations in healthy BeaglesDiez, Marianne ; Hornick, Jean-Luc ; Baldwin, Paule et alin American Journal of Veterinary Research (1997), 58Objective-To evaluate effects of a blend of fructo-oligosaccharides and sugar beet fiber (4:1) at 3 incorporation rates on nutrient digestibility and plasma glucose, insulin, alpha-aminonitrogen, urea ... [more ▼]Objective-To evaluate effects of a blend of fructo-oligosaccharides and sugar beet fiber (4:1) at 3 incorporation rates on nutrient digestibility and plasma glucose, insulin, alpha-aminonitrogen, urea, cholesterol, and triglycerides concentrations measured weekly in nonfed dogs and during a 360-minute period after a meal. Animals-8 castrated 1 to 1.4-year-old young adult male Beagles weighing 10.0 to 13.5 kg. Procedure-Diets containing 2 incorporation rates of a blend of fructo-oligosaccharides and sugar beet fiber (5 and 10% on a dry matter basis [diets B and C, respectively]) were compared with a control diet without additional fiber (diet A). The 3 diets were evaluated for ability to modify digestibility of dry and organic matter, protein, fat, and ash and for effects on plasma glucose, insulin, alpha-aminonitrogen, urea, cholesterol, and triglycerides concentrations. Each diet was fed for 6 weeks; plasma samples were collected weekly before feeding and after feeding on the last day of the period, During 1 week at the end of the 6-week period, dogs were kept in metabolic cages. Each period of the block was followed by a 4-week washout period. Results-Incorporating the blend of fructo-oiigosaccharides and sugar beet fiber in the diet was associated with greater passage of wet feces (diets B and C) and lower protein digestibility (diet C). Postprandial glucose (diet C), urea (diets B and C) and triglyceride (diets B and C) concentrations were significantly (P < 0.01) decreased. Weekly preprandial measurements were characterized by decreased urea (diets B and C), cholesterol (diet C), and triglycerides (diets B and C) concentrations (P < 0.001). Conclusion-Chronic consumption of fermentable fiber is associated with mildly decreased protein digestibility and with metabolic effects in nonfed or fed dogs. Clinical Relevance-A blend of fructo-oligosaccharides and sugar beet fiber should he tested as a dietary aid for treatment of chronic diseases, such as diabetes mellitus or hyperlipidemia, in dogs. [less ▲]Detailed reference viewed: 32 (2 ULg) Earliest Taeniate Bisaccates from the Amazon basin are not older than Westphalian.Loboziak, S; Melo, J.H.G.; Dino, R et alin Geobios (1997), 30(4), 467-474Detailed reference viewed: 3 (0 ULg) The Cloning And Sequencing Of An Ovine C-Myc CdnaKiermer, V.; Dequiedt, Franck ; Masengo, R. et alin DNA Sequence : The Journal of DNA Sequencing & Mapping (1997), 7(3-4), Detailed reference viewed: 23 (7 ULg) Simulation of the morphology of the Jovian UV north aurora observed with the Hubble Space TelescopeGrodent, Denis ; Gladstone, G. R.; Gérard, Jean-Claude et alin Icarus: International Journal of Solar System Studies (1997), 128(2), 306-321A model simulating Earth views of UV auroral arcs and diffuse emissions in the Jovian north polar region is described. It assumes a Chapman profile of vertical brightness distribution and various ... [more ▼]A model simulating Earth views of UV auroral arcs and diffuse emissions in the Jovian north polar region is described. It assumes a Chapman profile of vertical brightness distribution and various horizontal structures, Simple geometric cases are described to illustrate the dependence on the altitude, atmospheric scale height, and central meridian planetary longitude (CML) of an idealized amoral morphology seen from Earth orbit, The numerical simulation makes it possible to assess the importance of limb brightening and the contribution from high altitude auroral emission located behind the planetary limb. As an application of the simulation model, four images obtained with the Wide Field and Planetary Camera 2 (WFPC2) on board the Hubble Space Telescope are used to determine the characteristics of their auroral (discrete and diffuse) structures, The apparent brightness distribution along the arcs can only be reproduced if intrinsic longitudinal (or local time) variations are introduced, in addition to the path length effects of the viewing geometry, A composite average auroral distribution is built by mapping 10 WFPC2 images from the same dataset, It illustrates the dichotomy frequently observed between a narrow single structure are at System III longitudes larger than 180 degrees (or morning sector) and the multiple are and broad diffuse emission at longitudes less than 180 degrees (or afternoon sector), It is shown that the equatorial auroral emission boundary is located between the 6R(J) and the 30R(J) magnetic field line footprints of the Goddard Space Flight Center (GSFC) O-6 model. (C) 1997 Academic Press. [less ▲]Detailed reference viewed: 17 (7 ULg) Characterization of non pigmented B16 melanoma cell-derived cytotoxic factors.Siwek, B.; De Pauw-Gillet, Marie-Claire ; Quetin-Leclercq, J. et alin Chemico-Biological Interactions (1997), 103(1), 59-73We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests ... [more ▼]We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests used showed that ultrafiltrated conditioned media (CM U1 fraction) contained several cytotoxic factors with a Mw lower than 1000 Da. These factors seemed to act either directly or indirectly on cell membranes, mitochondria, on the cell cycle and on protein and DNA synthesis. A cytotoxic activity could be found even after high dilution of CM U1. These cytotoxic factors were rapidly released by B16 cells in culture, independently of cell confluence. Their activities in the treated cells were also very fast and the cytotoxic effects were irreversible after only a few hours of treatment. These factors were not intermediate products during melanogenesis, neither polyamines, nor proteases. At least one of them seemed to be a small acidic and basic stable peptide without disulfide bounds but not heat stable. The synthesis of at least one of these cytotoxic factors was inhibited by cycloheximide and the cytotoxic activity was partially destroyed by pronase and trypsin, but not by pepsin. The cytotoxicity was not modified by copper complexants or free radical inhibitors (bovine serum albumin (BSA), tyrosine, superoxyde dismutase (SOD), catalase, vitamin E). Furthermore the levels of glutathione peroxydase activity and reduced glutathione did not change after treatment by CM U1 as compared to controls. [less ▲]Detailed reference viewed: 23 (0 ULg) Synthesis and characterization of monodisperse spherical zirconia particlesVan Cantfort, Olivier; Michaux, Bernard; Pirard, René et alin Journal of Sol-Gel Science and Technology (1997), 8Detailed reference viewed: 31 (3 ULg) Energy savings in methanol synthesis: Use of heat integration techniques and simulation tools.Maréchal, François; Heyen, Georges ; Kalitventzeff, Boris in Computers & Chemical Engineering (1997), 21(Suppl. S), 511-516Starting with a classical process for producing methanol using the reforming and synthesis steps, a combined approach applying simulation models and a new synthesis strategy, named Effect Modelling and ... [more ▼]Starting with a classical process for producing methanol using the reforming and synthesis steps, a combined approach applying simulation models and a new synthesis strategy, named Effect Modelling and Optimisation (EMO), has been used to optimise the energy efficiency of the process. The method allows to identify different ways of improving the energy efficiency of the process. The modifications concern the synthesis reactor and the reforming reactor designs, the exploitation of the purge stream as fuel gas to satisfy the process requirement and its integration to a gas turbine system. The EMO approach allows to target the impact of a process modification at the global level of the energy cost of the process, including the combined production of heat and mechanical power in a gas turbine and the steam network. Starting with a classical methane conversion of 60% for the classical system, we identify solutions with up to 93% of the overall methane conversion when we transform the net mechanical power produced into methane savings at the country level. The interest of the approach is the possibility of computing the impact of the process modifications suggested by the analysis of the shape of the heat cascade on the overall energy balance of the plant without having to simulate in many details the steam and the heat exchanger network. [less ▲]Detailed reference viewed: 27 (3 ULg) Quelques reflexions sur les contraintes alimentations dans la production caprine en milieu tropicalMayombo, Asangule Pierre; Hornick, Jean-Luc in Le N'Dama (1997)Detailed reference viewed: 7 (1 ULg) Does the artificial grammar learning paradigm involve the acquisition of complex information?Meulemans, Thierry ; Van der Linden, Martial in Psychologica Belgica (1997), 37(1-2), 69-88Detailed reference viewed: 60 (2 ULg) Physical activity, obesity, and cardiovascular risk factors in children. The Belgian Luxembourg Child Study II.Guillaume, Michèle ; Lapidus, L.; Bjondorp, P. et alin Obesity Research (1997), 5(6), 549-56Physical activity was measured in relation to cardiovascular (CV) risk factors in a randomly selected population of 1028 children from Province de Luxembourg in Belgium, a mainly rural area with a high ... [more ▼]Physical activity was measured in relation to cardiovascular (CV) risk factors in a randomly selected population of 1028 children from Province de Luxembourg in Belgium, a mainly rural area with a high prevalence of such risk factors among adults and children. Physical activity was estimated as participation in sport activities, a major indicator of leisure-time physical activity in schoolchildren, and physical inactivity was estimated as frequency and duration of television (TV) watching. Boys participated more frequently in sport activities than girls did (p = 0.001). A majority of the children watched TV daily. After age adjustment, bodyweight (girls, p < 0.012; boys, p < 0.027) and, in boys, body mass index (BMI) (p < 0.039) were related to days per week of TV watching. No significant relationships with other CV risk factors remained after adjustments for BMI. In analyses of independent contributions of age, TV watching, and sports activity on CV risk factors, age showed highly significant relationships. In boys, TV showed relationships with BMI (p < 0.04) and (borderline) with systolic blood pressure, independent of age and sports activity, whereas the latter was significantly related to subscapular skinfold (p < 0.04) and (borderline) with triceps skinfold and cholesterol. In girls, no significant independent contributions to risk factor associations were found. The father's education was directly associated with sports activities, whereas the mother being a housewife showed negative relationships to physical activity and positive to TV watching in their children, suggesting socioeconomic influence on the activity patterns of children. Furthermore, registrations suggested less physical activity in the most rural part of the area. It is concluded that children in this mainly rural area watch TV frequently. In boys, physical inactivity, measured both as TV watching and as registrations of sports activities, contributes independently to body fat mass. In girls, no contribution or weaker contributions of physical inactivity were found. This suggests that contributory factors leading to obesity might be different in girls and boys. [less ▲]Detailed reference viewed: 49 (7 ULg) Le rôle de l'expertBoxho, Philippe in Société d'étude du dommage corporel (1997)Detailed reference viewed: 35 (4 ULg) Familial Crohn's Disease: A Study of 18 FamiliesFranchimont, D.; Belaiche, Jacques ; Louis, Edouard et alin Acta Gastro-Enterologica Belgica (1997), 60(2, Apr-Jun), 134-7The high frequency of familial Crohn's disease (CD) suggests a genetic predisposition. The most recent data from epidemiology and molecular biology are consistent with a multifactorial, polygenic ... [more ▼]The high frequency of familial Crohn's disease (CD) suggests a genetic predisposition. The most recent data from epidemiology and molecular biology are consistent with a multifactorial, polygenic inheritance with a possible genetic heterogeneity. The aim of our study was, first to compare familial and sporadic CD on the basis of the type and location of the disease, and age at diagnosis, and second, to evaluate among families, the concordance rate for the type and location of the disease. PATIENTS AND METHODS: 18 families with 2 (n = 16) and 3 (n = 2) affected first degree relatives were studied. They were compared to a population of 154 sporadic CD coming from the same gastroenterology unit. RESULTS: Age at diagnosis was the same in sporadic and familial CD. There was an increased frequency of ileal (p = 0.02), and fibro stenotic (p = 0.005) CD and a decreased frequency of colonic (p = 0.006) and inflammatory (p = 0.02) disease, in familial CD. There was a significant increase in concordance rate for fibrostenotic disease (p < 0.001) and a decrease for inflammatory disease (p < 0.01), among the families. The observed concordance rate for the location of the disease was not significantly different from the expected one. In conclusion, these data suggest that CD may be heterogenous and that different clinical patterns may be determined either by genetic or environmental factors. [less ▲]Detailed reference viewed: 10 (1 ULg) Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury.Plumier, Jean-Christophe ; Krueger, A. M.; Currie, R. W. et alin Cell Stress & Chaperones (1997), 2(3), 162-7Using transgenic mice constitutively expressing the human inducible Hsp70, we examined the role of Hsp70 on cell survival after focal cerebral ischemia. Twenty-four hours after permanent occlusion of the ... [more ▼]Using transgenic mice constitutively expressing the human inducible Hsp70, we examined the role of Hsp70 on cell survival after focal cerebral ischemia. Twenty-four hours after permanent occlusion of the middle cerebral artery, no difference in infarct area was detected between Hsp70-transgenic and non-transgenic mice. In the non-transgenic mice, many pyramidal neurons of the ipsilateral hippocampus were observed to be pyknotic. However, in all Hsp70-transgenic mice, hippocampal pyramidal neurons showed normal morphology and no evidence of pyknosis. This suggests that constitutive expression of Hsp70 reduces the extent of damage following permanent middle cerebral artery occlusion. [less ▲]Detailed reference viewed: 16 (0 ULg) Comparative evaluation of five hygroscopic condenser humidifiers during short-term postoperative mechanical ventilationSottiaux, Thierry; Meurice, F.; Mignolet, Ghislaine et alin Acta Anaesthesiologica Italica & Anaesthesia and Intensive Care in Italy (1997), 48(1-2), 59-68Detailed reference viewed: 18 (4 ULg) Production and activation of matrix metalloprotease-9 (MMP-9) by HL-60 promyelocytic leukemia cellsDevy, L.; Noël, Agnès ; Baramova, E. et alin Biochemical and Biophysical Research Communications (1997), 238Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of ... [more ▼]Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of extracellular matrix components. As shown by gelatin zymography, HL-60 cells constitutively released significant amounts of proMMP-9 (92 kDa) and moderate amounts of proMMP-2 (72 kDa). Furthermore, casein zymography confirmed the presence of serine proteases in the form of pro-urokinase. Activation of proMMP-9 was dependent on the plasminogen activator/plasmin (PA/plasmin) system and was inhibited by aprotinin. MMP-9 was only detected in cellular extracts or conditioned media incubated with HL-60 cells, indicating that cells are essential to the activation process. Addition of plasminogen increased by 3-fold the basal invasive rate of these cells across a matrigel layer (2.1%versus0.7% in control cells after 4 h of incubation). Taken together, these results indicate that HL-60 cells exhibit an autocrine activation mechanism of proMMP-9 via the PA/plasmin system and that activation of proMMP-9 increases their invasive potential [less ▲]Detailed reference viewed: 12 (5 ULg) Loss of calcyphosin gene expression in mouse and other rodentsClément, S.; Dumont, J.; Schurmans, Stéphane in Biochemical and Biophysical Research Communications (1997), 232alcyphosine-for calcium binding and regulated by cyclic AMP through phosphorylation protein-is a target of both the cyclic AMP and the Ca(+2)-phophatidylinositol cascades first isolated from dog thyroid ... [more ▼]alcyphosine-for calcium binding and regulated by cyclic AMP through phosphorylation protein-is a target of both the cyclic AMP and the Ca(+2)-phophatidylinositol cascades first isolated from dog thyroid, and then from rabbit and human brain. Although the exact function of this 24kD protein is unknown, calcyphosine could be implicated in the cross-signaling between these cascades to coordinate cellular proliferation and differentiation. Here, we report the sequence of a pseudogene which is the murine calcyphosine homologue, and demonstrate that it represents the unique sequence homologous to the dog calcyphosine gene in the murine genome. The lack of expression of this murine pseudogene in brain and thyroid-two major sites of dog calcyphosine expression-was extended to 5 other rodents, and suggest the existence of alternative pathway(s) to fill the function of calcyphosine in rodents [less ▲]Detailed reference viewed: 43 (5 ULg) Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes. Molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-Rh C2B9H11]Felekidis, Apostolos ; Goblet-Stachow, M.; Liégeois, Jean-François et alin Journal of Organometallic Chemistry (1997), 536-537Detailed reference viewed: 24 (5 ULg) Comparison of hindquarter metabolite uptakes in Belgian Blue double-muscled bulls at maintenance or during fattening.Hornick, Jean-Luc ; Van Eenaeme, Christian ; Diez, Marianne et alin Journal of Animal Science (1997), 75(12), 3331-41Metabolism of muscle growth in the hindquarter was investigated by the arterio-venous difference (AVD) technique in Belgian Blue double-muscled type bulls at maintenance or at fattening. The bulls were ... [more ▼]Metabolism of muscle growth in the hindquarter was investigated by the arterio-venous difference (AVD) technique in Belgian Blue double-muscled type bulls at maintenance or at fattening. The bulls were fitted with an aortic ultrasonic blood flow probe and with catheters in the aorta and vena cava. They were offered a diet allowing for maintenance (MP) during a period of 15 d, at the end of which measurements were made over 3 d. Bulls were then given a fattening diet (FP) and the measurements were repeated. Arterial blood flow was approximately 1 L/min greater when the bulls were standing than when lying. Blood flow was 2 L/min higher during FP than during MP. The AVD and uptake of glucose were maximal at 1400 and 1600. Uptake of alpha-amino nitrogen decreased immediately after a meal. The increase in glucose from MP to FP fitted very well with the calculated energy needs for muscle growth. The AVD and uptake of alpha-amino nitrogen, total amino acids, and total nonessential amino acids were negative during MP and positive and significantly higher during FP. There was also a significant increase in AVD and uptake of essential and branched-chain amino acids when the bulls were changed from MP to FP. When changing from maintenance to fattening, the incremental glucose and amino acid hindquarter uptake provided energy and supply for muscle protein accretion, respectively. The level of alanine transamination was also sharply reduced. [less ▲]Detailed reference viewed: 20 (1 ULg) Parathyroid Hormone in the Treatment of Involutional Osteoporosis: Back to the FutureReginster, Jean-Yves ; Taquet, A. N.; Fraikin, G. et alin Osteoporosis International (1997), 7(Suppl 3), 163-8Detailed reference viewed: 15 (5 ULg) Emission from cobalt in type Ia supernovaeLiu, W; Jeffery, D J; Schultz, D R et alin Astrophysical Journal (1997), 489Detailed reference viewed: 1 (0 ULg) Darkness promotes flowering in the absolute long-day requiring plant, Lolium temulentum L. CeresPérilleux, Claire ; Bernier, Georges ; Kinet, Jean-Mariein Journal of Experimental Botany (1997), 48(307), 349--351Vegetative plants of the long-day grass Lolium temulentum L. Ceres were exposed to threshold long days or light breaks. Protracted darkness given just afterwards clearly promoted flowering and was weakly ... [more ▼]Vegetative plants of the long-day grass Lolium temulentum L. Ceres were exposed to threshold long days or light breaks. Protracted darkness given just afterwards clearly promoted flowering and was weakly inductive on its own. The promotive effect of darkness was restricted to floral induction since further apical development was weak. [less ▲]Detailed reference viewed: 6 (0 ULg) Long-wavelength behavior of the exchange-correlation kernel in the Kohn-Sham theory of periodic systemsGhosez, Philippe ; Gonze, X.; Godby, R. W.in Physical Review. B : Condensed Matter (1997), 56(20), 12811-12817The polarization dependence of the exchange-correlation (re) energy functional of periodic insulators within Kohn-Sham (KS) density-functional theory requires a O(1/q(2)) divergence in the re kernel for ... [more ▼]The polarization dependence of the exchange-correlation (re) energy functional of periodic insulators within Kohn-Sham (KS) density-functional theory requires a O(1/q(2)) divergence in the re kernel for small vectors q. This behavior, exemplified for a one-dimensional model semiconductor, is also observed when an insulator happens to be described asa KS metal, or vice versa. Although it can occur in the exchange-only kernel, it is not found in the usual local, semilocal, or even nonlocal approximations to KS theory. We also show that the test-charge and. electronic definitions of the macroscopic dielectric constant differ from one another in exact KS theory, but are equivalent in the above-mentioned approximations. [less ▲]Detailed reference viewed: 8 (0 ULg) Три замечательных слависта Льежского Университета. Trois personnalités marquantes de la slavistique à l’Université de Liège (1898-1984)Mouton, Charles in Slavica Gandensia (1997), 24Detailed reference viewed: 21 (1 ULg) The effect of dispersion and atomisation conditions on the compaction response of silicon nitride granulesDestoop, Vincent; Mertens, Anne ; Hendrix, W. et alin Key Engineering Materials [=KEM] (1997), 132-136The relationship between the dispersion conditions of silicon nitride slurries and the compaction behaviour of spray dried granules is reported in the case of two commercial powders. Two parameters have ... [more ▼]The relationship between the dispersion conditions of silicon nitride slurries and the compaction behaviour of spray dried granules is reported in the case of two commercial powders. Two parameters have been retained: the solid loading, varied between 10 and 30 vol.% and the degree of stability of the suspension, controlled by adjustment of the pH. [less ▲]Detailed reference viewed: 61 (4 ULg) - Purification and characterization of tomato leaf (Lycopersicon esculentum Mill.) hydroperoxide lyase.Fauconnier, Marie-Laure ; Perez, A. G.; Sanz, C. et alin Journal of Agricultural and Food Chemistry (1997), 45(11), 4232-4236Hydroperoxide lyase (HPOOH lyase) was extracted from tomato leaves (Lycopersicon esculentum Mill.) and purified to apparent homogeneity by fractionated precipitation with polyethylene glycol 6000, ion ... [more ▼]Hydroperoxide lyase (HPOOH lyase) was extracted from tomato leaves (Lycopersicon esculentum Mill.) and purified to apparent homogeneity by fractionated precipitation with polyethylene glycol 6000, ion exchange chromatography, and ultrafiltration. The enzyme is a trimer of 73 000 Da units with a molecular mass of 216 000 (determined by native-PAGE and gel filtration); its pI is around 4.9. Enzyme activity measurments realized with 9- and 13-hydroperoxides of linoleic acid (9-La OOH and 13-La OOH, respectively), R-linolenic acid (9-Ln OOH and 13-Ln OOH, respectively), and ç-linolenic acid (9-çLn OOH and 13-ç-Ln OOH, respectively) revealed a great affinity for 13-Ln OOH. The enzyme is rapidly inhibited by its substrate (13-Ln OOH), but preincubation with the other five hydroperoxides, which are not degraded by the enzyme, also resulted in activity inhibition. Dialysis could not restore the activity. When 13-Ln OOH is reduced in its corresponding alcohol or converted to its methyl ester, the inhibition is reduced. [less ▲]Detailed reference viewed: 19 (4 ULg) Development of a monoclonal antibody to urinary degradation products from the C-terminal telopeptide 1 chain of type I collagen. Application in an enzyme immunoassay and comparison to Crosslaps TM ElisaFledelius, C; Kolding, I; Qvist, P et alin Scandinavian Journal of Clinical & Laboratory Investigation (1997), 57Detailed reference viewed: 14 (3 ULg) Aerogel compression theoretical analysisPirard, René ; Pirard, Jean-Paul in Journal of Non-Crystalline Solids (1997), 212(2-3), 262-267Several authors have empirically shown that, in aerogels, a power law exists between the mechanical moduli and the bulk density. An exponent value can be determined from mercury porosimetry curves. The ... [more ▼]Several authors have empirically shown that, in aerogels, a power law exists between the mechanical moduli and the bulk density. An exponent value can be determined from mercury porosimetry curves. The shrinkage of aerogels under mercury pressure follows a buckling mechanism which links the pore size to the exerted pressure. The present study relates the exponent to the pore volume distribution which can be described by a hierarchical model valid in a large range of pore size, so a physical meaning is given to the exponent. [less ▲]Detailed reference viewed: 40 (1 ULg) Pd/SiO2-cogelled aerogel catalysts and impregnated aerogel and xerogel catalysts: Synthesis and characterizationHeinrichs, Benoît ; Noville, Francis ; Pirard, Jean-Paul in Journal of Catalysis (1997), 170(2), 366-376Pd/SiO2 aerogel catalysts have been synthesized by cogelation of tetraethoxysilane with complex Pd2+[NH2-CH2-CH2-NH-(CH2)(3)-Si(OCH3)(3)](2) containing a hydrolysable silyl group. Pd catalysts have also ... [more ▼]Pd/SiO2 aerogel catalysts have been synthesized by cogelation of tetraethoxysilane with complex Pd2+[NH2-CH2-CH2-NH-(CH2)(3)-Si(OCH3)(3)](2) containing a hydrolysable silyl group. Pd catalysts have also been prepared by impregnation of silica aerogels and xerogels with solutions of this complex or Pd2+(NH3)(4) followed by drying under hypercritical conditions or under vacuum. It appears that, in cogelled samples, the Pd2+ complex acts as a nucleation agent in the formation of silica particles. The resulting catalysts are then composed of completely accessible palladium crystallites with a diameter of about 2.3 nm located inside silica particles with a monodisperse microporous distribution centered on a hydraulic radius of 0.43 nm. The continuous meso- and macropore distribution is located in voids between particles and between aggregates constituted of those particles. In impregnated samples, it appears that Pd particles are located outside SiO2 particles. The relation between the texture of cogelled and impregnated catalysts and their behavior toward sintering has been studied in detail. In cogelled samples, it has been shown that Pd crystallites cannot migrate because they are trapped in the pores of SiO2 particles. These catalysts are sinterproof during hypercritical drying, When Pd crystallites are not trapped inside SiO2 particles, hypercritical drying leads to an extensive sintering of metal particles. During calcination of impregnated catalysts dried under vacuum, sintering occurs to a various extent depending on the support texture. The Pd crystallites size decreases when the pore size distribution is shifted toward the small sizes. (C) 1997 Academic Press. [less ▲]Detailed reference viewed: 74 (19 ULg) Positron emission tomography in parkinsonismSalmon, Eric in Acta Neurologica Belgica (1997), 97(3), 187-191Detailed reference viewed: 6 (0 ULg) Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue.Fernandez, P. L.; Merino, M. J.; Gomez, M. et alin Journal of Pathology (The) (1997), 181(1), 80-6Galectin-3 is a 31 kD beta-galactoside-binding lectin which is expressed by several types of non-neoplastic and neoplastic cells and which may be involved in cell-extracellular matrix interactions. An ... [more ▼]Galectin-3 is a 31 kD beta-galactoside-binding lectin which is expressed by several types of non-neoplastic and neoplastic cells and which may be involved in cell-extracellular matrix interactions. An immunohistochemical study has been made of the expression of galectin-3, as well as its ligand, laminin, in a spectrum of benign and malignant thyroid neoplasms and in some non-neoplastic conditions. Immunohistochemistry with anti-human recombinant galectin-3 antibody showed consistent, intense positivity in the neoplastic cells of 18 cases of papillary carcinoma and less intense staining in the five anaplastic carcinomas studied. In addition, two out of three poorly differentiated carcinomas, three out of six medullary carcinomas, and four out of eight follicular carcinomas had less intense or focal positivity. One case of Hurthle cell carcinoma showed scattered strongly positive cells. Eight follicular adenomas, three hyperplastic nodules, five nodular goitres, and normal thyroid tissue were negative. Galectin-3 mRNA expression was also evaluated in three of the papillary carcinomas, two follicular adenomas, and one hyperplastic nodule with matched normal tissue. Northern blot analysis demonstrated mRNA overexpression in the three cases of papillary carcinomas, whereas normal and benign tissues were negative. Laminin distribution in neoplastic and non-neoplastic tissue varied with architectural patterns but did not correlate with galectin-3 immunohistochemical expression. We conclude that expression of galectin-3 is limited to inflammatory foci in normal and benign thyroid tissue and is a phenotypic feature of malignant thyroid neoplasms, especially papillary carcinomas. [less ▲]Detailed reference viewed: 5 (1 ULg) Long term follow-up of patients with acute myelogenous leukemia who received the daunorubicin, vincristine, and cytosine arabinoside regimen.Beguin, Yves ; Sautois, Brieuc ; Forget, Patricia et alin Cancer (1997), 79(7), 1351-4BACKGROUND: In 1985, the authors published a study of acute myelogenous leukemia (AML) patients treated with a chemotherapeutic regimen that was then considered intensive. Ten years later, the authors ... [more ▼]BACKGROUND: In 1985, the authors published a study of acute myelogenous leukemia (AML) patients treated with a chemotherapeutic regimen that was then considered intensive. Ten years later, the authors reanalyzed the same cohort to determine whether the very promising actuarial results observed at 5 years held after longer follow-up. METHODS: Between 1977 and 1982, 61 patients with AML were treated with a protocol consisting of daunorubicin, vincristine, and cytosine arabinoside induction followed by consolidation and maintenance for a total of 2 years. The complete remission (CR) rate was 66%, 84% in males versus 47% in females (P < 0.005). At the time of the first analysis in 1984, the overall survival (OS) was 17%, the projected 5-year continuous CR rate (CCR) 32%, and the disease free survival (DFS) rate 29%, with the best results observed for males and for patients ages 40-60 years (P < 0.05). RESULTS: When the data were reanalyzed 11 years later in 1995, the results were 14% OS, 23% CCR, and 16% DFS at 5 years. However, these figures dropped to 8%, 18%, and 11% at 10 years and to 8%, 12%, and 7% at 15 years, respectively. Among the 40 CR patients, 31 relapsed (up to 13 years after CR), and all died within 1.6 years after relapse. Nine patients were in CCR: 4 died of unrelated causes (suicide, alcoholic cirrhosis, acute peritonitis, or bladder carcinoma), 1 was lost to follow-up after 11 years, 2 were alive and well at 17 years at last follow-up, and 2 were transplanted in first CR and were doing well at 13 and 14 years at last follow-up. The survival advantage for males over females persisted (P = 0.0197), but the advantage for patients age 40-60 years did not hold. CONCLUSIONS: These long term data indicate that actuarial analysis at 5 years may overestimate the cure rate of AML patients because a number of late relapses do occur. However, the picture is blurred by the incidence of death not related to leukemia or its treatment; and when these patients were censored at the time of death, 17% of CR patients were still projected to be alive and free of leukemia after 17 years. [less ▲]Detailed reference viewed: 30 (6 ULg) Ruptured Aneurysm of the Profunda Femoral Artery Associated with Polyaneurysmal DiseaseDefraigne, Jean-Olivier ; Vasquez, C.; Limet, Raymond in Acta Chirurgica Belgica (1997), 97(2), 93-6A 73-year-old man was admitted for rupture of an atherosclerotic aneurysm of the profunda femoris artery associated to popliteal and bilateral axillary arteries aneurysms. The aneurysm of the profunda ... [more ▼]A 73-year-old man was admitted for rupture of an atherosclerotic aneurysm of the profunda femoris artery associated to popliteal and bilateral axillary arteries aneurysms. The aneurysm of the profunda femoris artery was developed between the branches of the crural nerves. Considering the patency of the superficial femoral artery and of the leg arterie, and to avoid injury to the crural nerve, no reconstruction of the profunda femoris was attempted. The aneurysm was ligated proximally and buttress sutures were placed on the site of rupture to achieve thrombosis of the aneurysms. Most of the published cases of aneurysm of the profunda femoris artery are false aneurysms developed after various trauma. Atherosclerotic aneurysm of the profunda femoris artery is a rare lesion and rupture is exceptional. [less ▲]Detailed reference viewed: 14 (0 ULg) Higgs boson search at photon collider for M(h) = 140-GeV - 190-GeVGinzburg, I. F.; Ivanov, Igor in Physics Letters B (1997), 408A Higgs boson within the mass range $M_H=140-190$ GeV can be discovered at a photon collider in the reaction $\gamma\gamma\to WW$ (with real or virtual W) with the luminosity integral about 1 fb$^{-1 ... [more ▼]A Higgs boson within the mass range$M_H=140-190$GeV can be discovered at a photon collider in the reaction$\gamma\gamma\to WW$(with real or virtual W) with the luminosity integral about 1 fb$^{-1}$. The reasonable resolution in the effective mass of the WW system is required. [less ▲]Detailed reference viewed: 9 (0 ULg) Leaf carbohydrate status in Lolium temulentum during the induction of floweringPérilleux, Claire ; Bernier, Georges in New Phytologist (1997), 135(1), 59-66Unifoliated plants of Lolium temulentum L. ev. Ceres, a qualitative long-day grass, were induced to flower by one 24-h long day (LD) or by one 8-h short day (SD) advanced by 1 2 h in the normal regime, so ... [more ▼]Unifoliated plants of Lolium temulentum L. ev. Ceres, a qualitative long-day grass, were induced to flower by one 24-h long day (LD) or by one 8-h short day (SD) advanced by 1 2 h in the normal regime, so-called 'displaced short day' (DSD). Standard light for SD and DSD was a mixture of fluorescence and incandescence at 400 µmol m2 s-1 whereas the extension period of the 24-h LD was solely incandescence at 10-15 µmol m2 s-1. The DSD system was first characterized by the timings of floral induction, stimulus translocation and apical development. Carbohydrates in the blade tissues and in leaf exudate were analysed comparatively in vegetative and induced plants. Fructans were not detected in the leaf tissues whereas sucrose and starch were found to be present in similar amounts. In SD, their contents exhibited a diurnal fluctuation and were not in large excess. The common change observed during the two inductive treatments was that starch remained at a high level during the LD extension, even though the lighting was unsuitable for photosynthesis, and increased transiently in DSD. Sucrose was the major sugar contained in the leaf exudate. Its content increased when flowering was induced, but not at the same time in the two systems. In LD, sucrose exudation rose when plants were returned to standard light after the inductive cycle, i.e. after the LD stimulus had left the leaf blade. By contrast, during the DSD, sucrose was transported at the same time as the floral stimulus. Results are discussed together with the methods used to time stimulus translocation and their implications. [less ▲]Detailed reference viewed: 40 (4 ULg) La cavernostomie: une ancienne technique parfois efficace dans le traitement des abcès pulmonairesDefraigne, Jean-Olivier ; Siquet, J.; Limet, Raymond in Revue Médicale de Liège (1997), 52(7), 498-501Detailed reference viewed: 17 (2 ULg) Nos élèves préfèrent Pythagore à NewtonMonseur, Christian in Pilotinfo (1997), 20(septembre), Detailed reference viewed: 5 (0 ULg) Biosynthesis of 5-aminolevulinic acid via the Shemin pathway in a green sugar beet callusBisbis, B.; Billard, J. P.; Huault, C. et alin Biologia Plantarum (1997), 40(4), 493-4975-Aminolevulinic acid synthase (ALAS) has been detected in a normal (auxin- and cytokinin-dependent) green sugar beet callus under light and under darkness. ALAS activity was lower when the callus was ... [more ▼]5-Aminolevulinic acid synthase (ALAS) has been detected in a normal (auxin- and cytokinin-dependent) green sugar beet callus under light and under darkness. ALAS activity was lower when the callus was grown under light. The supply of precursors of the Shemin pathway (glycine and succinate) to dark-grown callus enhanced considerably the capacity of the 5-aminolevulinic acid (ALA) formation. Glutamate, γ-aminobutyrate or α-ketoglutarate also increased ALA accumulation. Such an accumulation was also obtained after inhibition of polyamine synthesis. The results show that glutamate or its derivatives might feed the Shemin pathway in conditions preventing glutamate to be used through the Beale pathway. [less ▲]Detailed reference viewed: 5 (0 ULg) Les taxanes : un nouvelle classe d'agents cytotoxiquesJerusalem, Guy ; Fillet, Georges in Médecine et Hygiène (1997), 55Paclitaxel et docetaxel sont de novueaux agents cytotoxiques qui présentent un mécanisme d'action tout à fait original. Les taxanes favorisent la polymérisation des dimères alpha et bêta de la tubuline et ... [more ▼]Paclitaxel et docetaxel sont de novueaux agents cytotoxiques qui présentent un mécanisme d'action tout à fait original. Les taxanes favorisent la polymérisation des dimères alpha et bêta de la tubuline et sont responsables d'anomalies stables de la structure des microtubules ainsi que de la formation anarchique de nombreux astères non fonctionnels. Des résultats encourageants sont observés dans le traitement de deuxième ligne d'une grande variété de cancers. La toxicité est acceptable si l'on utilise une prémédication anti-allergique. Le paclitaxel est indiqué dans le traitement de première ligne du cancer ovarien avancé et de deuxième ligne du cancer du sein métastatique réfractaire aux anthracyclines. Le remboursement dans d'autres indications est à l'étude dans les années à venir. [less ▲]Detailed reference viewed: 88 (1 ULg) La lamotrigine (Lamictal).Scheen, André in Revue Médicale de Liège (1997), 52(11), 738-40Detailed reference viewed: 43 (0 ULg) The effects of ammonium sulphate deposition and root sinks on soil solution chemistry in coniferous forest soilsCarnol, Monique ; Ineson, Phil; Anderson, J. M. et alin Biogeochemistry (1997), 38The effects of enhanced (NH4)(2)SO4 deposition on soil solution cation and anion concentrations and annual ionic fluxes were followed using a standardised experimental protocol in six European coniferous ... [more ▼]The effects of enhanced (NH4)(2)SO4 deposition on soil solution cation and anion concentrations and annual ionic fluxes were followed using a standardised experimental protocol in six European coniferous forests with contrasting soil types, pollution inputs and climate. Native soil cores containing a ceramic suction cup were installed in the field, roofed and watered every two weeks with local throughfall or local throughfall with added (NH4)(2)SO4 at 75 kg NH4+-N ha(-1) a(-1). Living root systems were established in half of the lysimeters. Untreated throughfall NH4+-N deposition at the sites ranged from 3.7 to 29 kg ha(-1) a(-1). Soil leachates were collected at two weekly intervals over 12 months and analysed for volume, and concentrations of major anions and cations. Increases in soil solution NO3- concentrations in response to N additions were observed after 4-9 months at three sites, whilst one sandy soil with high C:N ratio failed to nitrify under any of the treatments. Changes in NO3- concentrations in soil solution controlled soil solution cation concentrations in the five nitrifying soils, with Al3+ being the dominant cation in the more acid soils with low base saturation. The acidification responses of the soils to the (NH4)(2)SO4 additions were primarily related to the ability of the soils to nitrify the added NH4+. pH and soil texture seemed important in controlling NH4+ leaching in response to the treatments, with two less acidic, clay/clay loam sites showing almost total retention of added NH4+, whilst nearly 75% of the added N was leached as NH4+ at the acid sandy soils. The presence of living roots significantly reduced soil solution NO3- and associated cation concentrations at two of the six sites. The very different responses of the six soils to increased (NH4)(2)SO4 deposition emphasise that the establishment of N critical loads for forest soils need to allow for differences in N storage. capacity and nitrification potential. [less ▲]Detailed reference viewed: 17 (0 ULg) Impaired LTP induction in dentate gyrus of calretinin-deficient miceSchurmans, Stéphane ; Schiffmann, S. N.; Gurden, H. et alin Proceedings of the National Academy of Sciences of the United States of America (1997), 94Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting ... [more ▼]Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting and have investigated the associated phenotype. Cr2/2 mice were viable, and a large number of morphological, biochemical, and behavioral parameters were found unaffected. In the normal mouse hippocampus, Cr is expressed in a widely distributed subset of GABAergic interneurons and in hilar mossy cells of the dentate gyrus. Because both types of cells are part of local pathways innervating dentate granule cells andyor pyramidal neurons, we have explored in Cr2/2 mice the synaptic transmission between the perforant pathway and granule cells and at the Schaffer commissural input to CA1 pyramidal neurons. Cr2/2 mice showed no alteration in basal synaptic transmission, but long-term potentiation (LTP) was impaired in the dentate gyrus. Normal LTP could be restored in the presence of the GABAA receptor antagonist bicuculline, suggesting that in Cr2/2 dentate gyrus an excess of g-minobutyric acid (GABA) release interferes with LTP induction. Synaptic transmission and LTP were normal in CA1 area, which contains only few Cr-positive GABAergic interneurons. Cr2/2 mice performed normally in spatial memory task. These results suggest that expression of Cr contributes to the control of synaptic plasticity in mouse dentate gyrus by indirectly regulating the activity of GABAergic interneurons, and that Cr2/2 mice represent a useful tool to understand the role of dentate LTP in learning and memory [less ▲]Detailed reference viewed: 34 (3 ULg) Vieillissement normal, démence d'Alzheimer et mémoire de travailVan der Linden, Martial ; Collette, Fabienne ; Andrès Bénito, Pilarin Psychologie Française (1997), 42Detailed reference viewed: 35 (11 ULg) L'acétylcholinestérase du système olfactif de la carpe Cyprinus carpio L. (Poissons, Cyprinidae): formes moléculaires et inhibition in vivo et in vitro par le carbofuranHaubruge, Eric ; Toutant, Jean-Pierrein Belgian Journal of Zoology (1997), 127Detailed reference viewed: 30 (0 ULg) Transition probabilities for forbidden lines in Cr IIQuinet, Pascal in Physica Scripta (1997), 55Detailed reference viewed: 21 (0 ULg) Relative and absolute in Leibniz' physics and metaphysicsBouquiaux, Laurence in Epistemologia (1997)Detailed reference viewed: 19 (2 ULg) Identification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with MHC class I moleculesVanneste, Yves; Ntodou-Thomé, Agnès; Vandersmissen, Eric et alin Journal of Neuroimmunology (1997), 76This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ... [more ▼]This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ± 5 ng immunoreactive (ir) NT/106 cells, of which 5% is associated with plasma cell membranes. HPLC analysis of NT-ir present in human TEC showed a major peak of NT-ir corresponding to NT1–13. NT-ir was not detected in the supernatant of human TEC cultures. Using an affinity column prepared with a anti-MHC class I monoclonal antibody, NT-ir-related peptides were retained on the column and eluted together with MHC class I-related proteins. According to the elution time on HPLC of these peptides, they correspond to intact NT1–13, as well as to smaller fragments of NT1–13. [less ▲]Detailed reference viewed: 26 (2 ULg) Technical validation of a face mask adapted for dry powder inhalation in the equine speciesDuvivier, Dominique Hannia; Votion, Dominique ; Vandenput, Sandrina et alin Equine Veterinary Journal (1997), 29(6), 471-476Development of dry powder inhalation (DPI) for horses requires the use of an adapted face mask. In experiment I, 4 masks (A, B, C and D) were tested and factors influencing the delivery of the dry powder ... [more ▼]Development of dry powder inhalation (DPI) for horses requires the use of an adapted face mask. In experiment I, 4 masks (A, B, C and D) were tested and factors influencing the delivery of the dry powder were determined. Mask A was one which is commercially available for metered-dose inhalation. Mask B had the same shape as Mask A but an airtight rubber seal was added for the connection between the mask and horse's head. Mask C was a prototype adapted for DPI with connection for the DPI device between the nostrils, airtight expiratory valves in front of each nostril and airtight rubber seal to attach the mask on the horse's head. Mask D was the same as Mask C but the airtight expiratory valve was situated in front of one nostril and the connection for the DPI device was placed in front of the other nostril. Inhalet emptying and peak inspiratory pressure were measured on 5 healthy horses with each face mask. Both Masks A and B gave a low rate of inhalet emptying. Inspiratory pressures created in Masks C and D were negative enough to ensure inhalet emptying rates of mean +/- s.d. 98.28 +/- 1.79% and 100% respectively. In experiment 2, the face masks giving the greatest inhalet emptying were used to test the therapeutic efficacy of ipratropium bromide DPI. This was tested on 6 horses suffering from acute exacerbation of chronic obstructive pulmonary disease (COPD). At a dose of 200 micrograms/100 kg bwt, ipratropium administered with Mask D improved significantly pulmonary function measurements compared to baseline values and placebo inhalation. With Mask C, a double dose of ipratropium (400 micrograms/100 kg bwt) was necessary to improve these parameters compared to baseline values. This indicated the importance of locating the DPI device in front of one nostril. It was concluded that inhalet emptying is correlated to inspiratory pressures measured in the face masks. Secondly, these pressures are in turn dependent on the air-tightness of the mask, i.e. air-tightness of the expiratory valve and close connection between the horse's head and the mask. Thirdly, position of the DPI device in front of a nostril allows bronchodilation at a dose half that required when the device is placed between the nostrils. Finally DPI using Mask D (EquiPoudre) is a rapid, effective and well tolerated inhalation treatment for COPD horses. [less ▲]Detailed reference viewed: 67 (4 ULg) Histoires d'eDupont, Pascal in Math-Jeunes (1997), 80Two definitions of the number$e$,$\displaystyle\lim_{n\rightarrow\infty}\left(1+\frac1n\right)^n$and$\displaystyle\sum_{n=0}^\infty\frac1{n!}\$, ares shown equivalent.Detailed reference viewed: 51 (6 ULg) Techniques et indications de la bronchoscopie interventionnelle.CORHAY, Jean-Louis ; Bury, Thierry ; Radermecker, Marc et alin Revue Médicale de Liège (1997), 52(10), 657-65Detailed reference viewed: 18 (4 ULg) The size of nanoparticles after their incorporation in gastroresistant spheroidsDuvivier, F; Grandfils, Christian ; Léonard, F et alin Journal de Pharmacie de Belgique (1997), 52(3), 123Detailed reference viewed: 11 (0 ULg) L'artiste belge entre le mot et l'image (quelques éléments de comparaison entre Hergé, Michaux, Magritte)Defays, Jean-Marc in Texte : Revue de Critique et de Théorie Littéraire (1997), 21-22Detailed reference viewed: 28 (1 ULg) Radiation therapy duration influences overall survival in patients with cervix carcinoma.Coucke, Philippe ; Delaloye, J-F; Pampallona, S et alin International Journal of Gynecology & Obstetrics (1997), 57of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation ... [more ▼]of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to the duration of the therapies, taking 60 days (the 75th percentile) as an arbitrary cut-off. Results: The 5-year survival was 61% (SE. = 3%) for the therapy duration group of less than 60 days and 53% (SE. = 7%) for the group of more than 60 days. In terms of univariate hazard ratio (HR), the relative difference between the hvo groups corresponds to a 50% increase of deaths (HR = 1.53, 95% CI = 1.03-2.28) for the longer therapy duration group (P = 0.044). In a multivariate analysis, the magnitude of estimated relative hazards for the longer therapies are confirmed though significance was reduced (HR = 1.52, 95% CI = 0.94-2.45, P = 0.084). Conclusion: These findings suggesthat short treatment duration is a factor associated with longer survival in carcinoma of the cervix. 0 1997 International Federation of Gynecology and Obstetrics [less ▲]Detailed reference viewed: 15 (1 ULg) Les compétences en lecture des élèves de 8 à 12 ans en Communauté française de Belgique à la lumière des évaluations externesLafontaine, Dominique in Pilotinfo (1997), (19), 1-22Detailed reference viewed: 13 (2 ULg) Roquentin et les types sans importance socialeDenis, Benoît in Etudes Françaises (1997), XXXIII(3), 105-119Detailed reference viewed: 6 (0 ULg) Surveillance des états hypertensifs sévèresBrichant, Jean-François in Percentile (1997), 2Detailed reference viewed: 5 (2 ULg) Variability in Lithic Assemblages across Space: Differential Responses to Raw Material ContextMiller, Rebecca in Notae Praehistoricae (1997), 17Detailed reference viewed: 18 (2 ULg) Use of the alpha parameter method to calculate matrix corrections for infinitely thick targets (TTPIXE) with two different incident beam energiesDelbrouck Habaru, J.; Roelandts, I.; Strivay, David et alin Nuclear Instruments & Methods in Physics Research Section B (1997), 129(1), 92-100The alpha parameter correction method for calculating matrix effects in PIXE data does not require a priori knowledge of the major element composition of the matrix but implies the determination of a so ... [more ▼]The alpha parameter correction method for calculating matrix effects in PIXE data does not require a priori knowledge of the major element composition of the matrix but implies the determination of a so-called alpha parameter linking two independent phenomena: X-ray absorption and proton energy loss. The method extrapolated to the infinitely thick targets (TTPIXE) has been previously studied using two PIXE measurements in two different geometric configurations. The present Study deals with the possibility of using pairs of PIXE measurements at two different energies to obtain the alpha corresponding to thick samples (TTPIXE). The experimental conditions and error minimization problems are discussed. General tables allowing an easy use of the method are presented. [less ▲]Detailed reference viewed: 36 (0 ULg) Physical activity and cardiovascular risk factors in children. The Belgian Luxembourg Child Study.Guillaume, Michèle ; Lapidus, L.; Bjorntorp, P.in Obesity Research (1997)Detailed reference viewed: 16 (0 ULg) La maladie de Buerger: aspects cliniques et pronostiquesVAN DAMME, Hendrik ; Deprez, E.; DEFRAIGNE, Jean et alin Revue Médicale de Liège (1997), 52(10), 675-82Detailed reference viewed: 17 (0 ULg) "Saint Lambert au banquet de Jupille". Auguste Chauvin (1810-1884) et la peinture d'histoireGeorge, Philippe in Bulletin de la Société Royale Le Vieux-Liège (1997), T. XIII, n° 276Detailed reference viewed: 151 (16 ULg) Are Amphipathic Asymmetric Peptides Ubiquitous Structures For Membrane Destabilisation?Rahman, M.; Lins, Laurence ; Thomas, Annick et alin Journal of Molecular Modeling (1997), 3(5), 203-215The fusion of some viruses (SIV, BLV, etc) to host cells implicates short fragments of the fusion protein that are asymmetric amphipathic helices in molecular modelling. The tilted orientation of these ... [more ▼]The fusion of some viruses (SIV, BLV, etc) to host cells implicates short fragments of the fusion protein that are asymmetric amphipathic helices in molecular modelling. The tilted orientation of these fragments at a water/lipid interface is directly related to their fusogenic capacity. On this basis, we have searched for fragments of sequences corresponding to “viral fusion peptides” in other proteins. We have developed a strategy to detect them from primary sequences. Many candidates were detected, especially in transmembrane areas of membranous proteins, in signal sequences and in globular proteins. We suggest that they are involved in the dynamics of lipid-protein interactions. [less ▲]Detailed reference viewed: 16 (2 ULg) Phenylarsine oxide inhibits ex vivo HIV-1 expressionEdeas, M.; Arbault, S.; Legrand-Poels, Sylvie et alin Biomedicine & Pharmacotherapy (1997)Detailed reference viewed: 7 (0 ULg) Combined Ring Inversion and Side Group Rotation in Geminal Diphosphoryl Substituted Pyrrolinoxyl Radicals: ESR Analysis of Chemical Exchange between Four Nonequivalent SitesRockenbauer, Antal; Mercier, Anne; Le Moigne, François et alin Journal of Physical Chemistry A (1997), 101(43), 7965-7970The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found ... [more ▼]The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found, for the 2,2-disubstituted compounds 2 and 3, dramatic changes in the spectra were observed as a function of the temperature. These changes were explained by a four-site chemical exchange model including both ring inversion and hindered rotation around the carbon-phosphorus bonds. For radical 3, the presence of additional 5,5-dimethyl substitution can completely block rotations around carbon-phosphorus bonds for certain ring geometries, while for other ring conformations chemical exchange still occurs through combined inversionrotation processes. An effective two-site model composed of nonequivalent sites and a superposition model composed of a pair of exchanging conformers and a pair of nonexchanging conformers were used to simulate spectrum variations. A satisfactory fit was obtained over the entire temperature range investigated. From the temperature dependence of the exchange frequencies the potential barriers for ring inversion (27 kJ/mol), for combined inversion-rotation (11 kJ/mol), and for rotation around the carbon-phosphorus bonds (14 kJ/mol) were estimated. [less ▲]Detailed reference viewed: 19 (2 ULg) The TEL gene products: nuclear phosphoproteins with DNA binding properties.Poirel, H.; Oury, Cécile ; Carron, Clémence et alin Oncogene (1997)The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute ... [more ▼]The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events. [less ▲]Detailed reference viewed: 4 (1 ULg) Hormonal control of adventitious rooting: Progress and questionsKevers, Claire ; Hausman, J. F.; Faivre-Rampant, O. et alin Journal of Applied Botany (1997), 71(3-4), 71-79According to the traditional concept, adventitious rooting is a single developmental process, controlled by one single chief actor, auxin. This concept is out-of-date. This review develops the arguments ... [more ▼]According to the traditional concept, adventitious rooting is a single developmental process, controlled by one single chief actor, auxin. This concept is out-of-date. This review develops the arguments for rooting as a process consisting of successive physiological phases, with different exogenous requirements. The levels of auxins, peroxidases, phenolic compounds, cytokinins, polyamines, and ethylene undergo typical changes during these phases. Their complex interactions are far from being elucidated. The changes characterizing the rooting inductive phase may be similar to those occurring during flowering evocation. Thus these changes seem to be more indicative of a shift in a developmental programme than of a specific organogenic process. [less ▲]Detailed reference viewed: 7 (0 ULg)