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See detailGenetic Diversity In Lima Bean (Phaseolus Lunatus L) As Revealed By Rapd Markers
Fofana, B.; Vekemans, X.; Du Jardin, Patrick ULg et al

in Euphytica (1997), 95(2),

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See detailGlucose turnover in humans in the basal state and after intravenous glucose: a comparison of two models.
Overkamp, D.; Gautier, J. F.; Renn, W. et al

in American Journal of Physiology (1997), 273(2 Pt 1), 284-96

This study investigated the ability of two models to represent glucose kinetics in the basal steady state and during an intravenous glucose tolerance test (IVGTT). Six young nonobese male subjects were ... [more ▼]

This study investigated the ability of two models to represent glucose kinetics in the basal steady state and during an intravenous glucose tolerance test (IVGTT). Six young nonobese male subjects were studied after an overnight fast. Two bolus injections of [U-13C]glucose were given 150 min apart, the first without and the second together with concomitant injection of unlabeled glucose. [3-3H]glucose was constantly infused throughout the study and served to provide an independent means for evaluation of system responses. A linear time-invariant three-compartmental model and the two-compartment time-variant model proposed by Caumo and Cobelli were used to interpret measured time courses of [U-13C]glucose and to reconstruct endogenous glucose production and glucose removal. The ability of the two models to describe the glucose tracer time course was comparable. Simulation studies showed that the two-compartmental time-variant system better predicted measured [3-3H]glucose concentration profiles than did the three-compartmental time-invariant model. However, endogenous glucose production and the integral of excess glucose removal over basal during the IVGTT derived from the two models were almost identical. [less ▲]

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See detailRecommandations pour la prévention de l’infection tuberculeuse dans les institutions de soins
Gosset, Christiane ULg; Prignot, J.; Schandevyl, W. et al

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (1997), 24(1), 50-56

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See detailMitochondrial Asparaginyl-Trna Synthetase Is Encoded By The Yeast Nuclear Gene Ycr24c
Landrieu, I.; Vandenbol, Micheline ULg; Hartlein, M. et al

in European Journal of Biochemistry (1997), 243(1-2),

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See detailExpérimentation médicale sur l'être humain. Propositions pour un cadre législatif.
Palermini, Patricia ULg; Delfosse, Marie-Luce

in Revue de Droit de la Santé = Tijdschrift voor Gezondheidsrecht (1997), (5), 333-344

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See detailRegolazione della crescité follicolare e luteinica. Ovulazione, corpo luteo e luteolisi
Drion, Pierre ULg; Ectors, Fabien; Hanzen, Christian ULg et al

in Riproduzione dei Ruminanti (1997), 14(9), 17-25

Most ovarian follicles (99.9%) will end up with follicular atresia. During antral stages atresia depends on a reduction of FSH levels secondary to estradiol and inhibin secretions by the dominant follicle ... [more ▼]

Most ovarian follicles (99.9%) will end up with follicular atresia. During antral stages atresia depends on a reduction of FSH levels secondary to estradiol and inhibin secretions by the dominant follicle. Plasma levels in estradiol higher than 12pg/ml for at least 12 hours in bovine will cause the reversal of the negative feed-back effect of estradiol on the hypothalamus inducing the preovulatory peak of LH. So that the ovulatory discharge does not occur prematurely, the dominant follicle also secretes GnSIF which desensitises the hypohtesis to the action of GnRH. After ovulation, the corupus luteum, a true endocrine gland, develops. [less ▲]

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See detailPirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties.
Bruhwyler, J.; Liégeois, Jean-François ULg; Geczy, J.

in Pharmacological Research (1997), 36(1), 23-33

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical ... [more ▼]

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical irreversible monoamine oxidase inhibitors. Its main mechanism of action consists of a selective and reversible inhibition of monoamine oxidase A. Secondarily, it exerts an inhibitory effect on noradrenaline and 5-hydroxytryptamine reuptakes. It has no effect on the dopaminergic and cholinergic systems. It has only a low potential for amplifying tyramine and noradrenaline pressor effect, which makes one expect that it will not be at the basis of a 'cheese effect'. Pirlindole has an absolute bioavailability of between 20 and 30% due to an extensive first-pass effect. Orally, the Tmax varies between 2.5 and 6 h in the rat and 0.8 and 2 h in the dog. Two phases of elimination (7.5 and 34-70 h) are measured in the rat and three phases in the dog (1.3, 10.8 and 185 h); it is extensively metabolized. The rat eliminates mainly unconjugated products while the dog eliminates mostly conjugated products. Acute and chronic toxicological studies have not revealed potentially dangerous effects of the drug at the usual doses. It does not present measurable mutagenic, clastogenic or carcinogenic properties. Thus, pirlindole shows pharmacological, pharmacokinetic and toxicological properties which make it suitable for the management of depression. [less ▲]

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See detailDevelopment of a positron emission tomography radiopharmaceutical for imaging thymidine kinase gene expression : Synthesis and in vitro evaluation of 9-{3-[18F] Fluoro-1-hydroxy-2-propoxymethyl guanine
Monclus, Michel; Luxen, André ULg; Cool, Vincent et al

in Bioorganic and Medicinal Chemistry Letters (1997), 7(14), 1879-1882

9-[(3-fluoro-1-hydroxy-2-propoxy)methyl]guanine (FHPG) 2 has been labeled with fluorine-18 and evaluated in vitro as a potential radiotracer for mapping gene expression in vivo with positron emission ... [more ▼]

9-[(3-fluoro-1-hydroxy-2-propoxy)methyl]guanine (FHPG) 2 has been labeled with fluorine-18 and evaluated in vitro as a potential radiotracer for mapping gene expression in vivo with positron emission tomography (PET). [less ▲]

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See detailPemphigus foliacé dans l'espèce équine : synthèse et description de 2 cas.
Amory, Hélène ULg; Beco, Luc; Desmecht, Daniel ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailLe syndrome hépato-pulmonaire
Lamproye, Anne ULg; Weber, T.; Delwaide, Jean ULg et al

in Revue Médicale de Liège (1997), 52(10), 666-670

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See detailNote sous Cassation, 7 mai 1996
Orban, Lionel ULg

in Actualités du Droit (1997)

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Gunaïkeia (1997), 2

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See detailInfluence du climat sur l'évolution de la population de tétras lyres Tetrao tetrix dans les Hautes-Fagnes de Belgique de 1967 à 1996
Loneux, Michèle ULg; Lindsey, James ULg; Ruwet, Jean-Claude

in Cahiers d'Ethologie (1997), 17(2-3-4), 345-386

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See detailExtensive Ulcerative Colitis and Extraintestinal Manifestations in a Patient with Hiv Infection and Significant Cd4 T-Cell Lymphopenia
Louis, Edouard ULg; Moutschen, Michel ULg; de Marneffe, Pierre et al

in Gastroentérologie Clinique et Biologique (1997), 21(11), 884-7

We report a heterosexual patient with HIV infection and a CD4 T-cell count of 0.45 x 10(9)/L who developed mild ulcerative proctitis, sacroileitis and oligoarthiritis. While he was treated with 5 ... [more ▼]

We report a heterosexual patient with HIV infection and a CD4 T-cell count of 0.45 x 10(9)/L who developed mild ulcerative proctitis, sacroileitis and oligoarthiritis. While he was treated with 5-aminosalicylic enemas, the patient rapidly developed severe pancolitis. An emergency colectomy without procetectomy was performed. A few months later, he suffered recurrence of ulcerative proctitis, aggravation of arthritic pain and developed anterior uveitis. All symptoms disappeared after proctectomy. There was no evidence for opportunistic infection or Kaposi's sarcoma. Antineutrophil cytoplasmic antibodies were positive and the HLA-B27 antigen was present. CD4 counts were lower during the phases of active disease than during remission. This case demonstrates that severe ulcerative colitis can occur in the presence of moderate T-cell defects. In view of a recent report of remission of Crohn's disease under comparable circumstances, it is possible that the extent of T-cell involvement in both diseases is radically different. [less ▲]

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See detailOzone-Induced Stimulation of Pulmonary Sympathetic Fibers: A Protective Mechanism against Edema
Delaunois, Annie ULg; Segura, P.; Dessy, Cécile ULg et al

in Toxicology and Applied Pharmacology (1997), 147(1), 71-82

Tropospheric ozone exerts well-described toxic effects on the respiratory tract. Less documented, by contrast, is the ability of ozone to induce protective mechanisms against agents that are toxic to the ... [more ▼]

Tropospheric ozone exerts well-described toxic effects on the respiratory tract. Less documented, by contrast, is the ability of ozone to induce protective mechanisms against agents that are toxic to the lungs. In particular, interactions between ozone and the sympathetic nervous system have never been considered. Using a model of permeability edema in isolated perfused rabbit lungs, we report here that, immediately after exposure of rabbits to 0.4 ppm ozone for 4 hr, the pulmonary microvascular responses to acetylcholine and substance P are completely blocked. Several lines of evidence, including partial inhibition of the ozone-induced protective effect by several drugs (alpha2- and beta-adrenergic antagonists, neuropeptide Y antagonist, guanethidine), measured levels of released catecholamines in blood and urine and the in vitro response of isolated lungs exposed to 0.4 ppm ozone all seem to suggest that ozone can stimulate pulmonary adrenergic fibers and induce the local release of catecholamines and neuropeptide Y, this resulting in transient protection against pulmonary edema. We also showed that, 48 hr after the exposure, ozone increased the baseline microvascular permeability and the response to low concentrations of acetylcholine [less ▲]

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See detailExpression of insulin-related peptides in the human thymus
Geenen, Vincent ULg; Lefebvre, Pierre ULg

in International Diabetes Monitor (1997), 9

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See detailElectrospray Mass Spectrometry Study of Selective Complexes of Polyammonium Macrotricyclic Ligands with Dicarboxylic Acids
Collette, Caroline ULg; Meunier, Cécile; De Pauw, Edwin ULg et al

in Rapid Communications in Mass Spectrometry : RCM (1997), 11

Macrocyclic and macropolycyclic polyammonium host molecules have been shown to complex a variety of inorganic and organic anions strongly and selectively. The selectivity of the complexation depends on ... [more ▼]

Macrocyclic and macropolycyclic polyammonium host molecules have been shown to complex a variety of inorganic and organic anions strongly and selectively. The selectivity of the complexation depends on the substrate lenght and on the size of the host cavity of the macrocycle. We describe in this article the analysis of the complexation of dicarboxylic acid substrates by a macrotricyclic host using electrospray mass spectrometry. [less ▲]

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See detailApplication of canonical transformation with missing values to multitrait evaluation of Jersey type
Gengler, Nicolas ULg; Wiggans, G. R.; Wright, J. R. et al

in Journal of Dairy Science (1997), 80(10), 2563-2571

A multitrait animal model was used to calculate predicted transmitting ability and reliabilities for final score and 15 linear type traits of 225,632 US Jersey cows. Records were adjusted for age and ... [more ▼]

A multitrait animal model was used to calculate predicted transmitting ability and reliabilities for final score and 15 linear type traits of 225,632 US Jersey cows. Records were adjusted for age and stage of lactation before analysis. The model contained effects for interactions of herd and date scored; year scored, parity, and age; and herd and sire; effects of permanent environment and additive genetics were also included. Of the 381,511 records included, some observations were missing for final score (8%), body depth (43%), and teat length (33%). The evaluation system used a canonical transformation, included several random effects, and estimated missing values with each iteration. Inbreeding was considered in the computations. Convergence was achieved in approximately 50 rounds of iteration. Correlations between animal and sire model predicted transmitting ability ranged from 0.56 to 0.95 and generally were higher for bulls than for cows and for more recent birth years. Genetic trend was strongly positive for dairy form, final score, and rear udder traits (height and width) and negative for udder depth. For other traits, genetic trend was small. This methodology should improve the accuracy of genetic evaluations for type traits of US Jerseys. [less ▲]

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See detailInventaire forestier régional et applications cartographiques.
Rondeux, Jacques ULg; George, B.; Lecomte, Hugues

in Silva Belgica (1997), 104(3),

Il est pratiquement possible de représenter, par voie cartographique, tous les résultats issus d'un inventaire réalisé par échantillonnage, que ce soit en termes de variables quantitatives réparties en ... [more ▼]

Il est pratiquement possible de représenter, par voie cartographique, tous les résultats issus d'un inventaire réalisé par échantillonnage, que ce soit en termes de variables quantitatives réparties en classes d'amplitudes fixées ou de variables qualitatives codées sur une échelle de valeurs prédéfinie. A la condition d'être de type systématique [RONDEUX, 1993], cet échantillonnage assure une représentation cartographique homogène d'autant plus fine, lisible et fiable que la maille définissant l'emplacement des unités de sondage est dense et que la variabilité de l'élément ou de la variable à illustrer est faible. La localisation géographique de l'information, en particulier forestière, permet de donner une autre dimension aux résultats et offre d'évidentes perspectives de valorisation de ceux-ci, en particulier lorsqu'il s'agit de problèmes relevant de la gestion de l'espace et de stratégies touchant son organisation à une large échelle. Ces propos sont illustrés par la réalisation de cartes relatives à une situation photographiée par le premier inventaire forestier wallon mis en oeuvre [RONDEUX, 1988] entre 1980 et 1984. Elles concernent, à titre d'exemple et compte tenu des contraintes exposées au paragraphe 2, la répartition entre propriétés publiques et privées, les types de peuplement (feuillus ou résineux) et la structure de ceux-ci, les volumes à l'hectare de la totalité du matériel ligneux vivant et les niveaux de productivité des peuplements d'épicéa commun. Nous envisagerons sur un plan général le type de relations unissant un inventaire par échantillonnage à une représentation cartographique thématique (paragraphe 2), nous présenterons ensuite les documents proposés après avoir précisé la définition aussi stricte que possible des variables entrant en ligne de compte (paragraphe 3) avant de terminer par une brève conclusion (paragraphe 4). [less ▲]

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See detailEn mai élis qui te plaît
Durand, Pascal ULg

in Liège Université (1997), (été), 3

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See detailDes auteurs dans les ruines. Parcours arbitraire
Delhalle, Nancy ULg

in Alternatives Théâtrales (1997)

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See detailObesity and nutrition. The Belgian Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Beckers, F. et al

in Obesity Research (1997)

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See detailSoluble and cell-associated transferrin receptor in lung cancer.
Dowlati, A.; Loo; Bury, Thierry ULg et al

in British Journal of Cancer (1997), 75(12), 1802-6

The expression of transferrin receptor (TfR) has been identified in many malignant tumours. In lung cancer, lymphoma and breast cancer, it has been shown that the expression of TfR correlates with tumour ... [more ▼]

The expression of transferrin receptor (TfR) has been identified in many malignant tumours. In lung cancer, lymphoma and breast cancer, it has been shown that the expression of TfR correlates with tumour differentiation, probably implying some prognostic value. A soluble form of TfR (sTfR) in human serum has been shown to be proportional to the number of cellular TfRs. Based on these data we examined the utility of measuring sTfR in the serum and bronchoalveolar lavage (BAL) fluid of patients with lung cancer (n = 32) and patients with chronic obstructive pulmonary disease (n = 22). BAL fluid was centrifuged to separate the supernatant from the cellular component. Cells were lysed in a detergent and cell-associated TfR was measured by enzyme-linked immunosorbent assay (ELISA) and expressed as ng 10(-6) cells in this cellular component. There was no difference in serum sTfR between the cancer and chronic obstructive pulmonary disease (COPD) groups. A higher level of cell-associated TfR was found in BAL of non-small-cell lung cancer patients than in COPD patients (P = 0.01). The calculated number of TfR molecules per cell in BAL correlated positively with the percentage of macrophages in BAL (P < 0.0001), suggesting that cell-associated TfR in BAL originates primarily from macrophages in this fluid. No correlation existed between BAL cell-associated TfR and tumour size, nodal status, the presence of metastases and serum sTfR. BAL cell-associated TfR was negatively correlated with BAL supernatant neuron-specific enolase (NSE) (P = 0.01). A combination of BAL supernatant NSE and cell-associated TfR detected lung cancer with a sensitivity of 91%, a specificity of 59% and positive and negative predictive values of 81% and 71% respectively. In conclusion, BAL cell-associated TfR may help in the differential diagnosis of lung cancer vs pneumonia. [less ▲]

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See detailLinear Benard-Marangoni instability in rigid circular containers
Dauby, Pierre ULg; Lebon, Georgy ULg; Bouhy, E.

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 56(1), 520-530

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See detailEvidence For The Assignment Of Two Strains Of Splv To The Genus Potyvirus Based On Coat Protein And 3' Non-Coding Region Sequence Data
Colinet, Dominique; Kummert, Jean; Lepoivre, Philippe ULg

in Virus Research (1997), 49(1), 91-100

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See detailDesigning and implementing a GIS in an international context
Pantazis, Dimos N; Cornélis, Bernard ULg

in Transactions in GIS (1997), 1(4), 301-320

International collaborations between private companies, national research laboratories, and universities in the field of GIS have opened up new ways of exchanging knowledge and experiences between ... [more ▼]

International collaborations between private companies, national research laboratories, and universities in the field of GIS have opened up new ways of exchanging knowledge and experiences between different countries. However, when a collaboration involves the actual design and implementation of an operational GIS, rather than simply theoretical or applied research, or the development of specific applications, many problems can arise, sometimes leading either to the partial success or the complete failure of the project. Some of these problems are frequently encountered in all kinds of international collaborations: problems arising from different cultural mentalities, difficulties establishing a single common leadership, difficulties with communication and information exchange, and so on. Problems relating to the specific nature of the GIS are also present, for example the absence of digital geographic data format standards, the absence of metadata standards, the omission to use GIS or IS design methods, etc. This paper focuses on a joint Sino-Belgian project for the design and implementation of an urban geographical information system (UGIS) integrating remote sensing techniques in Hangzhou city, China and examines the general, specific, and international aspects of the problems encountered in an international collaboration. [less ▲]

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See detailFusion Of Bovine Leukemia Virus With Target Cells Monitored By R18 Fluorescence And Pcr Assays
Zarkik, S.; Defrisequertain, F.; Portetelle, Daniel ULg et al

in Journal of Virology (1997), 71(1),

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See detailIdiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature.
Deprez, Manuel ULg; Born, Jacques; Hauwaert, Cécile ULg et al

in Acta Neuropathologica (1997), 94(4), 385-9

A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were ... [more ▼]

A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were suggestive of multiple meningeal neoplasms and a correct diagnosis was made only after meningeal biopsy. This 44-year-old patient had a previous history of an ill-defined systemic disorder associating episcleritis, erythroderma nodosa and multiple peripheral arthritis. We review previous reports of idiopathic cranial pachymeningitis with emphasis on radiological investigation techniques, histopathology and possible dysimmune mechanisms of pathogenesis. [less ▲]

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See detailHerpesvirus Of Turkeys Homologue Of Hsv Vp16 Is Structurally Related To Varicella Zoster Virus Trans-Inducing Protein Encoded By Orf 10
Kopacek, J.; Zelnik, V.; Brasseur, Robert ULg et al

in Virus Genes (1997), 15(1), 45-52

Expression of the immediate-early genes of alpha-herpesviruses is stimulated by a family of trans-inducing factors represented by VP16 of HSV-1 and ORF10 gene product of VZV. We have identified and ... [more ▼]

Expression of the immediate-early genes of alpha-herpesviruses is stimulated by a family of trans-inducing factors represented by VP16 of HSV-1 and ORF10 gene product of VZV. We have identified and determined the nucleotide sequence of the UL48 gene encoding the herpesvirus of turkeys (HVT) homologue of HSV VP16. The gene maps to the BamHI-J fragment and appears to be expressed in a form of bicistronic transcript together with UL49. The deduced amino acid sequence of the protein encoded by HVT UL48 gene shows 55% identity with MDV UL48 gene product. Like the majority of related proteins in other alpha-herpesviruses, the protein encoded by HVT UL48 gene lacks the acidic C-terminal tail, known to possess the transactivation capacity of HSV VP16. Hydrophobic cluster analysis has revealed that its predicted domain composition is closely related to the transactivator protein encoded by ORF10 of VZV. However, the putative amino-terminal activation domain of the HVT homologue of HSV VP16 does not contain a typical horseshoe-like hydrophobic cluster found in other alpha-herpesvirus homologues, suggesting either that it acts as a transactivator via a different activation domain or that its transactivation potential is diminished. [less ▲]

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See detailPerspective in the treatment of insulin resistance.
Scheen, André ULg

in Human Reproduction (1997), 12 Suppl 1

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including ... [more ▼]

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including upper body adiposity, glucose intolerance, hypertension, dyslipidaemia, etc.) in industrialized countries and its dramatic consequences for public health. Insulin sensitivity can be improved by non-pharmacological means, essentially reduction of excessive body weight, promotion of regular physical activity and modification of dietary habits, as well as, possibly, cessation of smoking and correction of subclinical magnesium deficiency. Currently available pharmacological means mainly include the biguanide compound metformin and possibly anti-obesity agents, such as (d-) fenfluramine, fluoxetine and benfluorex. New compounds aiming at improving the action of insulin are in development, especially the thiazolidinedione derivatives (e.g. troglitazone), known as 'insulin sensitizers'. Treatment of insulin resistance may have important gynaecological applications, essentially in polycystic ovary syndrome and, possibly, after menopause. Hopefully, improving insulin sensitivity could ameliorate the cardiovascular prognosis of numerous individuals having some or all components of insulin resistance syndrome. [less ▲]

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See detailAlteration of radiation response in vitro by simultaneous modulation of the de novo and salvage pathways to deoxynucleoside triphosphate pool by (E)-2′-Deoxy-(Fluoromethylene)cytidine and thymidine analogs
Coucke, Philippe ULg; Li, Ye-Xiong; Cottin, Eliane et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 39(2 (supp1)), 257

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See detailThe Burden of Hypopituitarism in Adults after Pituitary Surgery
Van Roijen, L.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Journal of Clinical Endocrinology and Metabolism (1997), 4(Suppl. B), 139-142

The burden of illness was assessed in 183 hypopituitary patients, with growth hormone deficiency, who had received pituitary surgery at the Centre Hospitalier Universitaire de Liège, Belgium. The Short ... [more ▼]

The burden of illness was assessed in 183 hypopituitary patients, with growth hormone deficiency, who had received pituitary surgery at the Centre Hospitalier Universitaire de Liège, Belgium. The Short-Form 36 (SF-36) was used to assess health status, and the Health and Labour Questionnaire was used to obtain data on production loss and reduced labout performance. Data on medical consumption were also collected. The overall response rate was 72 %. Hypopituitary patients reported a lower health status than that of the mean population in all but two dimensions of the SF-36 (bodily pain and physical functioning). A relativelu high percentage of hypopituitary patients reported being incapacitated for paid employment, and those in paid employment reported higher absence rates compared with reference data. However, while at work there was no indication that hypopituitary patients perform less well due to health problems than the average population. Healthcare costs for hypopituitary patients who had undergone pituitary surgery were higher than for the reference population. [less ▲]

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See detailPost-operative adjuvant therapy for non-small-cell lung cancer
Barthelemy, Nicole ULg; Johnson; Arriagada et al

in Lung Cancer (1997), 17(supp 1),

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See detailRelationships of growth hormone gene and milk protein polymorphisms to milk production traits in Simmental cattle
Falaki, M.; Prandi, A.; Corradini, C. et al

in Journal of Dairy Research (1997), 64(1), 47-56

The importance of milk proteins and the positive effect of administration of growth hormone (GH) on milk production, and the presence in some dairy cattle lines of greater GH concentrations prompted us to ... [more ▼]

The importance of milk proteins and the positive effect of administration of growth hormone (GH) on milk production, and the presence in some dairy cattle lines of greater GH concentrations prompted us to examine the presence of restriction fragment length polymorphism at the GH gene using the restriction enzyme TaqI and to investigate associations between this polymorphism in Simmental cows and bulls, as well as milk protein variants in Simmental cows, and milk production traits. Blood and milk were sampled from 279 Italian Simmental cows and semen was collected from 148 bulls of the same breed. Two fragment bands, denoted A and B, of 6200 and 5200 bp respectively, were examined and three patterns, AA, AB and BB, were found in both animal samples. All variants previously reported in other studies, for kappa, beta, and alpha(s1)-caseins, and beta-lactoglobulin, were found in the cows' samples. For the cows' samples, a BLUP (Best Linear Unbiased Predictor) analysis of results was performed using a REML (Restricted Maximum Likelihood) program and known heritabilities, whereas for bulls we have performed a General Linear Model analysis. The effect of GH gene polymorphism, using TaqI restriction enzyme, on milk production traits was not significant, but bulls of BB pattern had a higher breeding value for milk yield than AA bulls (P < 0.05). For the kappa-casein genotypic effects, cows of AB genotype gave milli with 1.53+/-0.70 g/kg less fat than cows of AA genotype. In addition, breeding values for milk protein content were significantly higher in BB bulls, with 0.87+/-0.32 and 0.71+/-0.34 g/kg more milk protein than AA and AB bulls respectively. Thus, our results revealed a GH gene polymorphism and indicated significant effects of milk protein polymorphisms on milk production traits in the Italian Simmental breed. [less ▲]

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See detailOrigine des produits animaux et empreinte génétique
Portetelle, Daniel ULg; Mortiaux, Frédéric; Burny, Arsène et al

in Agricontact (1997), 294

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See detailDiagenetic and paleogeographic significance of clay and other sedimentary components in the middle Devonian limestones of Western Ardennes, France
Chamley, H.; Proust, J. N.; Mansy, J. L. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (1997), 129

Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at ... [more ▼]

Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at Glageon in a structural context marked by small fault-controlled basins subjected to moderate overburden, tectonic and metamorphic constraints. Data on the clay mineral distribution, associated with detailed information on limestone facies/microfacies, as well as data on the depositional profile and sequence stratigraphic evolution of these rocks indicate strong carbonate diagenesis and moderate clay diagenesis, the latter being favoured by the early occurrence of the former, which prevented further fluid-rock interaction. The clay assemblage distribution, which roughly parallels the palaeomorphologic and palaeobathymetric shape of the Givetian continental margin, is organized in five successive zones indicating large-scale sequence stratigraphic evolution and the control of regional sea-level fluctuations. The clay and other sedimentary components provide additional information on the warm and variably humid climate, northern, relative to southern, terrigenous sources, the open sea relative to restricted depositional environments, the temporary tectonic rejuvenation of the continental hinterland and the chemical conditions allowing early diagenetic modifications. [less ▲]

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See detailLa responsabilité civile et professionnelle des administrateurs
Caprasse, Olivier ULg

in Actualités du Droit (1997)

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See detailInfluence of whole milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats
Hornick, Jean-Luc ULg; Clinquart, Antoine ULg; Van Eenaeme, Christian ULg et al

in Livestock Production Science (1997), 48

Influence of milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats. The use of milk as component ... [more ▼]

Influence of milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats. The use of milk as component of a fattening diet for bulls was studied in an experiment carried-out over 2 years with Belgian Blue bulls. The animals weighed 305 kg at the beginning of the experiment. In all, 15 bulls were given a control concentrate fattening diet (control group, CG), while 11 others were fed concentrate plus 6.5 to 11 1 whole milk per day according to weight or age (milk group, MG). The fattening period lasted for 174 and 181 d respectively in groups CG and MG. The MG-group had a higher killing-out percentage (P < 0.01) and the meat was characterized by a lower b* value and a lower dry matter content (P < 0.1). Whole milk in the diet increased the proportion of shorter chain and saturated fatty acids in fat (P < 0.001) and reduced the proportion of mono- and polyunsaturated acids (P < 0.05; P < 0.1). The extent of the changes were larger in subcutaneous and intermuscular fats than in intramuscular fat. [less ▲]

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See detailExamen échographique de l'articulation métacarpo-phalangienne. Corrélation signes échographiques - lésions
Denoix, Jean-Marie; Thill, Emanuelle; Houliez, Didier et al

in Pratique Vétérinaire Equine (1997), 29

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and ... [more ▼]

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and sensitivity and specificity of the technique have been calculated. [less ▲]

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See detailLuteinizing hormone increases the abundance of various transcripts, independently of the androgens, in the rat prostate.
Reiter, E.; Poncin, Joseph ULg; Hennuy, Benoît ULg et al

in Biochemical and Biophysical Research Communications (1997), 233(1), 108-12

Differential display analysis was carried out to find, in the rat prostate, genes that could be regulated by Luteinizing Hormone (LH), independently of the androgens. Hypophysectomized and castrated adult ... [more ▼]

Differential display analysis was carried out to find, in the rat prostate, genes that could be regulated by Luteinizing Hormone (LH), independently of the androgens. Hypophysectomized and castrated adult rats were treated with either LH, testosterone or saline. Regulated discrete bands have been eluted and reamplified. After Northern blotting, the levels of mRNA corresponding to 8 PCR fragments were significantly increased by LH treatment. None of these inserts were found to be induced by testosterone. One insert was subcloned, sequenced and identified as the ribosomial protein S 23. A competitive RT-PCR assay was carried out on the full length S 23 cDNA and confirmed that its mRNA levels were stimulated by LH but not by testosterone. These results strongly suggest that the LH membrane receptor, previously shown to be expressed in the rat prostate, has a physiological significance in this organ. Moreover, it appears that the effect of LH on the rat prostate are independent of the androgens. [less ▲]

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See detailHarm avoidance dimension of the Tridimensional Personality Questionnaire and serotonin-1A activity in depressed patients.
Hansenne, Michel ULg; Pitchot, William ULg; Moreno, A. G. et al

in Biological Psychiatry (1997), 42(10), 959-61

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See detailReflections on risk and resilience in adolescence
Born, Michel ULg; Jackson, Sandy; Jacob, Marie-Noël

in Journal of adolescence (1997), 20

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See detailGenetic Structure Of A Lima Bean Base Collection Using Allozyme Markers
Maquet, A.; Bi, Iz.; Delvaux, M. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1997), 95(5-6),

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See detailAutoregulation of endogenous glucose production in man.
Tappy, L.; Tounian, P.; Paquot, Nicolas ULg

in Biochemical Society Transactions (1997), 25(1), 11-3

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See detailMeasurements of the ground state ionization energy and wavelengths for the 1snp1P1 - 1s2 1S0(n=4-10) lines of O VII
Bartnik, A.; Biémont, Emile ULg; Dyakin, V. M. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1997), 30

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See detailDe différences en disparités : les effets d'un système éducatif 'non compréhensif'
Lafontaine, Dominique ULg

in Scientia Paedagogica Experimentalis (1997), XXXIV(2), 267-281

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique ... [more ▼]

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique, organisation en tronc commun ou en filières, présence ou non d'une carte scolaire) et différents indices de performance ou d'équité : performances moyennes en lecture à un test international comparatif, degré d'hétérogénéité des performances entre élèves, disparités de rendement selon l'établissement ou la filière fréquenté(e). Les résultats montrent que le redoublement, largement pratiqué en Communauté française de Belgique, ne débouche ni sur des meilleures performances, ni sur une réduction sensible des disparités entre élèves. L'absence de tronc commun et de sectorisation engendre en outre de fortes disparités selon la filière et selon l'établissement fréquenté. Le premier degré du secondaire de la Communauté française, organisé en système 'non compréhensif', semble ainsi de nature à amplifier plutôt qu'à corriger les inégalités entre élèves issus du primaire. [less ▲]

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See detailElastic vector-meson production at HERA
Cudell, Jean-René ULg; Royen, I.

in Physics Letters B (1997), 397

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See detailCharacterization of Clostridium perfringens isolates from goats.
Phukan, A.; Dutta, G.-N.; Daube, Georges ULg et al

in Indian Veterinary Journal (The) (1997), 74

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See detailHuman TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer
Jacquemin, Patrick; Martial, Joseph ULg; Davidson, Irwin

in Journal of Biological Chemistry (1997), 272(20), 12928-37

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in ... [more ▼]

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in skeletal and cardiac muscle, but the strongest expression is observed in the placenta and in placenta-derived JEG-3 choriocarcinoma cells. In correlation with its placental expression, we show that hTEF-5 binds to several functional enhansons of the human chorionic somatomammotropin (hCS)-B gene enhancer. We define a novel functional element in this enhancer comprising tandemly repeated sites to which hTEF-5 binds cooperatively. In the corresponding region of the hCS-A enhancer, which is known to be inactive, this element is inactivated by a naturally occurring single base mutation that disrupts hTEF-5 binding. We further show that the binding of the previously described placental protein f/chorionic somatomammotropin enhancer factor-1 to TEF-binding sites is disrupted by monoclonal antibodies directed against the TEA domain and that this factor is a proteolytic degradation product of the TEF factors. These results strongly suggest that hTEF-5 regulates the activity of the hCS-B gene enhancer. [less ▲]

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See detailEffect of diet and bST on mRNA for IGF-I binding proteins (BP)-2 and -3 in dairy cattle
Sharma, B. K.; Vandehaar, M. J.; Tucker, H. A. et al

in Journal of Dairy Science (1997), 80(suppl 1), 176

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See detailAcute Functional Iron Deficiency in Obese Subjects During a Very-Low-Energy All-Protein Diet
Beguin, Yves ULg; Grek, Vincent; Weber, Georges ULg et al

in American Journal of Clinical Nutrition (1997), 66(1), 75-9

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 ... [more ▼]

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 g protein after a 1-wk period during which total daily energy intake was progressively reduced to 1.26 MJ. Serum iron fell sharply by approximately equal to 50% (P < 0.0001), and despite a small decrease in total-iron-binding capacity, transferrin saturation decreased from 30 +/- 11% to 18 +/- 5% (P < 0.0001). Serum ferritin did not change significantly but serum soluble transferrin receptor (sTfR), an indicator of iron deficiency, increased progressively from 4630 +/- 1110 to 6070 +/- 1390 micrograms/L (P < 0.0001). Changes in sTfR correlated inversely with prior changes in serum iron. Changes in iron metabolism did not translate into changes in erythropoiesis or red cell indexes, but the white blood cell count decreased from 7.3 +/- 1.6 to 6.2 +/- 1.9 x 10(9)/L (P < 0.002). There was no evidence of deficiency for the other trace elements and minerals tested. Daily supplementation with 200 mg Fe in 18 other subjects only partially corrected these observations despite some increase in iron stores. These results indicate that during a 2-wk VLED serum iron is significantly depressed, inducing functional tissue iron deficiency too short in duration to produce alterations in red blood cell indexes. These changes are not mediated by absolute iron deficiency, inflammation, or protein malnutrition but could be related to alterations in the iron storage and release behavior of the reticuloendothelial cell during energy deprivation alone. [less ▲]

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See detailIA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry.
Gorus, F. K.; Goubert, P.; Semakula, C. et al

in Diabetologia (1997), 40(1), 95-9

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody ... [more ▼]

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody (IA-2-Ab) assay in 474 IDDM patients and 482 non-diabetic control subjects aged 0-3 years. IA-2-Ab were detected in 58% of the patients and 0.8% of control subjects. Their prevalence in patients was lower than that of islet cell autoantibodies (ICA; 73%) or glutamic acid decarboxylase (M(r) 65 kDa)-autoantibodies (GAD65-Ab; 82%) but higher than that of insulin autoantibodies (IAA; 42%). IA-2-Ab were more frequent in patients under age 20 years (70%) than between 20 and 40 years (45%; p < 0.001). In the whole IDDM group, 92% of patients were positive for at least one of the three molecular assays, which is higher than the positivity for the ICA assay (73%). Only 1% was negative in the molecular assays and positive in the ICA assay. IA-2-Ab levels were positively correlated with ICA titres (p < 0.001) and HLA DQ A1*0301-DQ B1*0.02 (p < 0.003) by multivariate analysis. In a group of 481 non-diabetic siblings (age 0-39 years) of IDDM patients only 7 were IA-2-Ab positive (1.5%). All seven were under age 20 years and positive for at least two other autoantibodies and for DQ A1*0301-DQB1*0302. Four of these seven developed IDDM during the 6-70-month follow-up period. The positive predictive value of IA-2-Ab (57%) was higher than that of ICA, GAD65-Ab or IAA alone, or in combination (< or = 20%) but these calculations are restricted by the relatively short observation period and the small number of cases. The only IA-2-Ab-negative case of pre-diabetes was also negative for IAA and GAD65-Ab, while it was strongly positive for ICA. In conclusion, IA-2-Ab show a high diagnostic specificity for IDDM and are predictive markers of impending diabetes in siblings of patients. In combination with other molecular antibody assays they may replace ICA testing in future. Our data also indicate that other autoantibodies than IA-2-Ab, GAD65-Ab and IAA contribute to ICA. [less ▲]

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See detailKlanknabootsingen in strips
Meesters, Gert ULg

in Nederlands van nu (1997), 45(3), 82-83

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See detailPropriétés des profils de flux d'induction magnétique dans les céramiques supraconductrices
Vanderbemden, Philippe ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1997), 2

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See detailSoil oribatid mite communities (Acari: Oribatida) from high Shaba (Zaïre) in relation to vegetation
Noti, M.-I.; André, H. M.; Dufrêne, Marc ULg

in Applied Soil Ecology (1997), 5(1), 81-96

Soil oribatid mite communities from three vegetation types (forest, woodland and savanna) are described in Luiswishi (high Shaba, Zaïre) and 151 species were recorded. Oribatid communities are organized ... [more ▼]

Soil oribatid mite communities from three vegetation types (forest, woodland and savanna) are described in Luiswishi (high Shaba, Zaïre) and 151 species were recorded. Oribatid communities are organized along a successional gradient which parallels the regressive sere defined by phytosociologists and going from the dense forest ("muhulu"), the local climax, to the savanna, passing through the woodland ("miombo"). Within this gradient, oribatid communities may vary depending on the habitat (presence of grass, high termitaria). The impact of seasons (dry vs. rainy season) is weak in the forest but drastic in savanna. The various soil oribatid communities are related to man's activities since the regressive sere results from repeated burnings and associated agricultural practices. [less ▲]

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See detailA global model of the biosphere : validation and applications to present and past climatic conditions
François, Louis ULg; Gérard, Jean-Claude ULg; Nemry, Bernard et al

in Sciences Géologiques. Bulletin (1997), 50(1-4), 89-107

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See detailScintigraphic visualization of intrathecal liposome biodistribution.
Umbrain, V; D'Haese, J; Alafandy, M et al

in Acta Anaesthesiologica Scandinavica (1997), 41(1 Pt 1), 25-34

BACKGROUND: Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers ... [more ▼]

BACKGROUND: Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers. Therefore, we observed the biodistribution of liposomes after intrathecal injection in rats by scintigraphic imaging during 24 h. METHODS: We administered 99mTc-labeled multilamellar (MLV) and small unilamellar vesicles (SUV) of defined size and volume dispersities into the cerebrospinal fluid at the lumbar level. Those vesicles were free of contamination by radiolabeled colloids as visualized by light and electron microscopy and of neurotoxic products from phosphatidylcholine hydrolysis and peroxidation, both during the preparation process and after 24 h incubation in cerebrospinal fluid at 37 degrees C in vitro. RESULTS: SUV immediately diffused from the lumbar site of injection to the head and were cleared between 1 and 24 h after injection. MLV were cleared more slowly from the spinal space and appeared in the head region 1 h after injection where they accumulated up to 24 h. These differences were explained in terms of vesicle sizes and volumes. SUV with 0.05 micron diameters were rapidly absorbed into the blood through the arachnoid granulations. In contrast, particles larger than the upper size limit of the arachnoid granulations permeability (+/- 8 microns) could accumulate in the head with a slow elimination rate. CONCLUSION: This difference in clearance from the intrathecal space outlines the importance of defining the size of the liposomes, the distribution of a tracer or a drug inside the liposomal preparation, the chemical stability and the absence of toxic degradation products of liposome formulations before clinical use. [less ▲]

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See detailRegolazione della crescité follicolare e luteinica. Folliculogenesi e atresia. Summa.
Drion, Pierre ULg; Beckers, Jean-François ULg; Ectors, Fabien ULg et al

in Summa (1997), 14(9), 5-16

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for ... [more ▼]

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for follicular recruiment. The recruited follicles produce estradiol, inhibin and follistatin which reduce the FSH secretion (negative feed back) reducing their support to hormonodependant follicles which become atresic. The dominant follicle, subjected to internal self stimulation is not sensitive to the reduction in FSH levels and carries on synthesising more and more estradiol. [less ▲]

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See detailInterobserver agreement on MNA nutritional scale of hospitalized elderly patients
Gazzotti, C.; Pepinster, A.; Petermans, Jean ULg et al

in Journal of Nutrition, Health & Aging (The) (1997), 1

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See detailComparative cytokine production by in vitro stimulated mononucleated cells from cord blood and adult blood.
Sautois, Brieuc ULg; Fillet, Georges ULg; Beguin, Yves ULg

in Experimental hematology (1997), 25(2), 103-8

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host ... [more ▼]

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host disease (aGVHD), a major life-threatening complication of allo-transplantation. The physiopathology of aGVHD implies the recognition of host alloantigens by donor T cells but also involves a cytokine cascade. In this cascade, interleukin (IL)-1, IL-2, IL-6, tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) produced by donor T cells and monocytes/macrophages play a major effector role. Therefore, we investigated whether the lower percentage of aGVHD in cord blood transplants could be related to a lower ability to produce these cytokines in vitro compared with adult blood. Mononucleated cells (MNCs) isolated from term cord blood and adult peripheral blood were stimulated with a combination of lipopolysaccharide and phytohemaglutinin and incubated for 96 hours. Levels of IL-1beta, IL-2, IL-3, IL-4, IL-6, TNF-alpha, IFN-gamma, and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured in the supernatants after various times of incubation. The productions of IL-1beta, IL-6, and GM-CSF were similar in stimulated cord and adult blood and IL-3 levels, though lower and delayed in cord blood, were not statistically different. On the other hand, we found markedly lower levels of IFN-gamma, TNF-alpha, and IL-4 in cord blood throughout the incubation period. The stimulated levels of IL-2 were similar in cord and adult samples throughout the first 48 hours of incubation but became significantly lower in cord blood after 72 and 96 hours. We suggest that the cytokine production pattern that characterizes cord blood could provide an explanation for the lower occurence of aGVHD following cord blood transplants. [less ▲]

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See detailHooliganisme: la délinquance des stades de football
Comeron, Manuel ULg

in Déviance et Société (1997), 21(1), 97-113

Analyse de la violence des supporters: individuelle, groupale, foule et sociétale.

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See detailCombined Effect of Web 2086 (Paf Antagonist) and Ketoprofen (Nsaid) on Paf-Induced Ex Vivo Platelet Aggregation in Bovine
Bastos da Silva, Miriam; Herion, Francine ULg; Raskinet, Renée ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1997), 44(2), 65-71

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich ... [more ▼]

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich plasma (PRP). WEB 2086 was infused intravenously over 1 min followed immediately by ketoprofen administration over 1 s (both drugs = 3 mg/kg), in a group of six healthy male Friesian calves. Depending on the PAF concentration, a reversible (10(-8)-10(-9) mol/l) and irreversible (10(-5)-10(-7) mol/l) platelet aggregation was observed. The reversible aggregation was completely blocked by pretreatment of the animal with WEB 2086 and ketoprofen. The inhibitory effects observed during the irreversible aggregation were 47.22%, 54.00% and 88.00% at 10(-5), 10(-6) and 10(-7) mol/l PAF, respectively. Moreover, the aggregation obtained in these condition became reversible. Maximal inhibitory effect of WEB 2086 and ketoprofen on PAF-induced platelet aggregation in calves was observed within 30 min after administration of both drugs. This inhibition persisted even after 24 h and was significantly different from control with P < 0.05. The combined effect of both drugs exceeded the sum of the individual effects (synergism). It was concluded that WEB 2086 and ketoprofen very effectively blocked PAF-induced bovine platelet aggregation in platelet-rich plasma. The study also suggested a synergism between both substances. [less ▲]

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See detailGénération innommable
Demoulin, Laurent ULg

in Textyles : Revue des Lettres Belges de Langue Française (1997), 14

Evocation de tendances romanesque ayant émergé dans les années 1980 et 1990 envisagées au moyen des notions discutables et discutées de "minimalisme" et de "postmodernité".

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See detailComment j'explore ... un patient avec hypotension orthostatique.
Scheen, André ULg; De Fooz, Geoffroy; Marchand, Monique ULg

in Revue Médicale de Liège (1997), 52(2), 116-9

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See detailSaint Lambert à Voroux-Goreux. L'ancienne statue du saint patron retrouvée ?
Marganne, Marie-Hélène ULg; Mélard, Marc

in Bulletin de la Société Royale Le Vieux-Liège (1997), 277

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See detailPresence of pap-, sfa- and afa-related sequences in necrotoxigenic Escherichia coli isolates from cattle : evidence for new variants of the AFA family
Mainil, Jacques ULg; Jacquemin, E.; Hérault, F. et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1997), 61

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See detailImproved emulsifying and foaming of whey proteins after enzymic fat hydrolysis
Blecker, Christophe ULg; Paquot, Michel ULg; Lamberti, I. et al

in Journal of Food Science (1997), 62(1), 48-

In an effort to improve emulsifying and foaming of sweet whey and whey protein concentrate, we studied the hydrolysis of the residual fat in these preparations with a sn 1,3 specific lipase. This ... [more ▼]

In an effort to improve emulsifying and foaming of sweet whey and whey protein concentrate, we studied the hydrolysis of the residual fat in these preparations with a sn 1,3 specific lipase. This enzymatic lipolysis would convert almost all triglycerides into mono- and diglycerides which have strong surface-active properties. Therefore, the emulsifying and foaming capacities of such modified whey products should be increased in comparison with native products, as shown by results presented at both neutral pH and those similar to a salad dressing emulsion. It was also demonstrated that emulsions and foams formed with lipase-treated whey preparations were more shelf-stable. [less ▲]

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See detailThe Photoabsorption Spectrum of Vinylchloride (C2H3Cl) in the 8-12 eV Range.
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg ... [more ▼]

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg transitions have been identified and classified. Tentative assignments were based on the ionization energies as measured by He(I)- and threshold photoelectron spectroscopy, as reported in the joined paper. Many features have been identified as being members of vibrational progressions belonging to the observed Rydberg series. [less ▲]

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See detailGravitational lensing by damped Ly-alpha absorbers
Smette, Alain; Claeskens, Jean-François ULg; Surdej, Jean ULg

in New Astronomy (1997), 2

Assuming that (i) damped Ly-alpha absorbers (DLAs) arise in present-day-like spiral galaxies which are immersed in isothermal dark matter halos, (ii) that these galaxies obey the Tully-Fisher sigma/sigma ... [more ▼]

Assuming that (i) damped Ly-alpha absorbers (DLAs) arise in present-day-like spiral galaxies which are immersed in isothermal dark matter halos, (ii) that these galaxies obey the Tully-Fisher sigma/sigma_* = (L/L_*)^1/alpha_TF and the Holmberg R_L/R_* = (L/L_*)^alpha_H relations, and (iii) that they follow the Schechter luminosity distribution, we describe how their observed number density (dN/dz), distribution of column density (f(N)) as well as inferred cosmological density of HI (Omega_HI) derived from DLA surveys are affected by gravitational lensing (GL). The `by-pass' effect causes the lines-of-sight (LOSs) towards background QSOs to avoid the central parts of galaxies and reduces their effective cross-section for absorption; the `amplification bias' leads observers to select QSOs whose LOSs preferentially cross galaxies close to their Einstein radius. As a consequence, the determination of the quantities dN/dz, f(N) and Omega_HI from DLA surveys does not only depend on the redshift z and luminosity L of galaxies responsible for the absorbers but also on the column density profile of HI within the galaxies and on the redshift z_q and magnitude b_q of the background QSOs. For most of the existing surveys using b_q <~ 19 QSOs, the amplification bias dominates the combined effect resulting in a slight overestimate of dN/dz, f(N) and Omega_HI. We mainly find that observational strategies presently used to produce high-z DLA surveys result in avoiding the signature of significant GL effects: following our model, we determine that an overestimate of Omega_HI by more than 10% is unlikely for the z > 1.7 existing surveys, but may reach ~= 35% for the low redshift ones. However, we show that, in the absence of extinction by dust and micro-lensing effects, surveys ideally designed to enhance GL effects, i.e. to search for DLAs at z ~ 0.5 in front of very bright (b_q ~= 16), high-z (z_q > 1) QSOs, may lead 1) to overestimate by up to ~= 90% the number of DLAs per unit redshift; 2) to bias the survey towards high HI column density systems so that it could contain up to 4 times as many such systems, thus 3) to overestimate by up to ~= 170% the cosmological density of gas associated with those DLAs. Identification of the galaxies responsible for the DLAs may be severely biased towards luminous galaxies if 2/alpha_TF - alpha_H>0 this latter effect is greatly increased for log N_HI > 21 DLAs. Hence, GL effects on the quantities derived from surveys for z ~ 0.5 DLAs are of the same order, but of opposite direction, as the effects of extinction by dust (cf. Fall & Pei, 1993). However, the GL and dust extinction effects do not compensate each other: combining them in a consistent way is necessary to interpret existing DLA surveys. Furthermore, the effects due to micro-lensing should be simultaneously taken into account. We intend to report the results on the complex interplay between macro-lensing, micro-lensing and dust in a subsequent paper. We briefly present statistical tests specifically designed to check whether GL affects existing DLA surveys, and assuming that extinction by dust is negligible. We only find indications of GL effects for the z < 1 ones which, if confirmed, might even be stronger than predicted by our model. We show that an independent work on the same subject by Bartelmann & Loeb (1996) incorrectly treats the inclination effects for the intervening galaxies, thus undermining some of their main results and conclusions. [less ▲]

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See detailEstimation of (co)variance components for Jersey type traits using a repeatability model
Gengler, Nicolas ULg; Wiggans, G. R.; Wright, J. R. et al

in Journal of Dairy Science (1997), 80(8), 1801-1806

(Co)variance components for final score and 15 linear type traits of Jersey cows were estimated by multitrait REML using multiple diagonalization and a repeatability model with 34,999 records of 22,354 ... [more ▼]

(Co)variance components for final score and 15 linear type traits of Jersey cows were estimated by multitrait REML using multiple diagonalization and a repeatability model with 34,999 records of 22,354 cows. Multiple diagonalization gave relative off-diagonals (ratio of squared off-diagonals to the product of diagonals) of <0.1%. Heritabilities and repeatabilities, respectively, were estimated as 0.29 and 0.48 for final score, 0.40 and 0.57 for stature, 0.26 and 0.39 for strength, 0.28 and 0.43 for dairy form, 0.13 and 0.25 for foot angle, 0.13 and 0.25 for rear legs (side view), 0.27 and 0.41 for body depth, 0.31 and 0.52 for rump angle, 0.22 and 0.33 for thurl width, 0.22 and 0.36 for fore udder attachment, 0.28 and 0.46 for rear udder height, 0.26 and 0.42 for rear udder width, 0.32 and 0.48 for udder depth, 0.20 and 0.36 for udder cleft, 0.29 and 0.46 for front teat placement, and 0.31 and 0.48 for teat length. Estimates of heritability generally were higher, and estimates of repeatability were lower, than values used previously for USDA genetic evaluations, which were based on data from the 1970s and early 1980s. Final score was highly correlated both genetically and phenotypically with dairy form and rear udder traits. These estimates of heritabilities and (co)variance components are necessary for multitrait genetic evaluation of linear type traits of US Jerseys. [less ▲]

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See detailStructural And Functional Properties Of The 154-171 Wild-Type And Variant Peptides Of Human Lecithin-Cholesterol Acyltransferase
Peelman, F.; Goethals, M.; Vanloo, B. et al

in European Journal of Biochemistry (1997), 249(3), 708-15

The 154-171 segment of the human lecithin-cholesterol acyltransferase (LCAT) enzyme was identified as the most stable amphipathic helix in the LCAT sequence. Its mean hydrophobicity, hydrophobic moment ... [more ▼]

The 154-171 segment of the human lecithin-cholesterol acyltransferase (LCAT) enzyme was identified as the most stable amphipathic helix in the LCAT sequence. Its mean hydrophobicity, hydrophobic moment and its orientation at a lipid/water interface are similar to those of some of the helical repeats of apolipoprotein A-IV and E. This domain was therefore proposed as a candidate peptide accounting for the association between LCAT and its lipid substrate. To investigate this hypothesis we synthesized the LCAT-(154-171)-peptide, two variants containing the natural Y156N and R158C mutations and a variant with increased hydrophobicity through Y156I, L160I, L163I and Y171W substitutions. The structural and lipid-binding properties of these synthetic peptides were investigated by turbidity, fluorescence, electron microscopy and circular dichroism. The wild-type peptide, the R158C variant in its dimeric form, as well as the more hydrophobic peptide, associated with phospholipids, whereas the Y156N and the R158C variant in its monomeric form did not. However, only the complexes generated with the hydrophobic variant were stable enough to resist dissociation during gel filtration. The wild-type peptide and hydrophobic variant formed discoidal complexes with dimyristoylglycerophosphocholine (Myr2GroPCho) as shown by negative staining electron microscopy. Comparison of the properties of the wild-type and hydrophobic variant LCAT-(154-171)-peptide stresses the contribution of the hydrophobic face of the amphipathic helix to the formation and stabilization of the peptide/lipid complexes. This is further confirmed by the decreased affinity of the Y156N variant peptide for lipids, as this mutation decreased the mean hydrophobicity of the hydrophobic face of the amphipathic helix. These results support the hypothesis that the 154-171 segment of LCAT might be involved in the interaction of the enzyme with its lipid substrate and suggest that the decreased activity of the Y156N natural LCAT mutant might result from a decreased affinity of this mutant for lipids. [less ▲]

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See detailComplications hepatiques de la chimiotherapie. De la cytolyse banale a la maladie veino-occlusive du foie.
Baron, Frédéric ULg; Beguin, Yves ULg

in Revue Médicale de Liège (1997), 52(2), 93-7

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See detailTricho-hepato-enteric syndrome: further delineation of a distinct syndrome with neonatal hemochromatosis phenotype, intractable diarrhea, and hair anomalies.
Verloes, A.; Lombet, J.; Lambert, Yves ULg et al

in American Journal of Medical Genetics (1997), 68(4), 391-5

We report on two sibs with syndromal congenital iron storage disease. Prenatal symptoms were IUGR, hydramnios, and placental hyperplasia. Clinical anomalies included hypertelorism and sparse, thin, curly ... [more ▼]

We report on two sibs with syndromal congenital iron storage disease. Prenatal symptoms were IUGR, hydramnios, and placental hyperplasia. Clinical anomalies included hypertelorism and sparse, thin, curly hair (trichomalacia). Clinical course was marked by intractable diarrhoea, with normal histological and enzymological studies, cholestatic jaundice, hepatomegaly appearing after 30 days, and progressive liver failure, leading to death after a few months. The only metabolic anomaly was progressive hypermethioninemia. Pathologic examination of both children showed a similar pattern of multivisceral iron deposit compatible with a diagnosis of neonatal hemochromatosis: extensive liver fibrosis or cirrhosis with nodular regeneration, cholestasis, ductular proliferation, and hepatic, pituitary, thyroidal, adrenal, and pancreatic iron deposition. The unusual course for neonatal hemochromatosis in both sibs combined with concordant extrahepatic anomalies suggest that they could have a specific iron storage syndrome with possible autosomal recessive inheritance, probably similar to the sibship reported by Stanckler et al. [Arch Dis Child, 57:212-216, 1982]. [less ▲]

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See detailSaisie-arrêt et concours des créanciers: fin d'une controverse, note sous Cass. (1ère ch.), 11 avr. 1997
Georges, Frédéric ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailDilatometric and calorimetric study of the graphitisation of high chromium cast iron
Terziev, L.; Lecomte-Beckers, Jacqueline ULg; Bojinov, V. et al

in Journal de Chimie Physique et de Physico-Chimie Biologique (1997), 94[5]

Cette étude est consacrée à la formation du graphite dans des fontes à haute teneur en chrome (8%) et spécialement à la détermination des conditions de formation de graphite secondaire par des traitements ... [more ▼]

Cette étude est consacrée à la formation du graphite dans des fontes à haute teneur en chrome (8%) et spécialement à la détermination des conditions de formation de graphite secondaire par des traitements thermiques adaptés. La solidification de la fonte étudiée a été examinée par analyse thermique différentielle (ATD). Les effets d'un traitement à haute température ont été examinés à la fois par calorimétrie et dilatomètre différentielle. Le graphite primaire se forme vers 950°C. Le graphite secondaire précipite sur le graphite primaire lors du traitement de déstabilisation de l'austénite à haute température. La forme et la quantité de graphite secondaire dépendent de la température de traitement. [less ▲]

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See detailEtude morphométrique du sabot et du petit sésamoïde du cheval
Gabriel, Annick ULg; Detilleux, J.; Jolly, S. et al

in Annales de Médecine Vétérinaire (1997), 147

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See detailHair follicle involvement in herpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Virchows Archiv : An International Journal of Pathology (1997), 430

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See detailRésultats à une enquête internationale en mathématiques
Monseur, Christian ULg

in Mathématiques & pédagogie (1997), 114

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See detailVaccinia virus immune evasion
Smith, G. L.; Symons, J. A.; Khanna, A. et al

in Immunological Reviews (1997), 159

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include ... [more ▼]

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept interleukins. This review provides an overview of such proteins, with an emphasis on work from our laboratory, and illustrates how the study of these proteins can increase our understanding of virus pathogenesis, the function of the immune system and how to make safer and more immunogenic poxvirus-based vaccines. [less ▲]

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See detailA novel seizure-induced synaptotagmin gene identified by differential display.
Babity, J. M.; Armstrong, J. N.; Plumier, Jean-Christophe ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94(6), 2638-41

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of ... [more ▼]

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of motor convulsions and the degeneration of neurons in the hippocampus and piriform cortex. Differential display PCR was used to identify mRNAs that are differentially expressed between degenerating and nondegenerating tissues in the brain after kainic acid-induced seizure activity. A novel cDNA fragment expressed in the degenerating hippocampus and piriform cortex, but not in the nondegenerating parietal cortex, was identified, cloned, and sequenced. This novel cDNA fragment identified a new member of the synaptotagmin gene family that is rapidly and transiently induced in response to seizure activity. Differential expression of this synaptotagmin gene, syt X, was confirmed by Northern blot analysis and in situ hybridization. This novel, inducible synaptotagmin gene may provide a direct link between seizure-induced neuronal gene expression and subsequent modulation of synaptic structure and function. [less ▲]

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See detailTwo centuries of vaccination
Vanderplasschen, Alain ULg; Smith, G. L.

in Annales de Médecine Vétérinaire (1997), 141

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See detailEvolution of coronary atherosclerosis in patients with mild coronary artery disease studied by serial quantitative coronary angiography at 2 and 4 years follow-up. The Multicenter Anti-Atheroma Study (MAAS) Investigators.
Vos, J.; de Feyter, P. J.; Kingma, J. H. et al

in European heart journal (1997), 18(7), 1081-9

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The ... [more ▼]

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The objective of this study was to describe the natural course of focal and diffuse coronary atherosclerosis over time. METHODS AND RESULTS: In 129 patients with mild coronary artery disease, but not on lipid-lowering medication, three coronary angiograms were made each 2 years apart. Nine hundred and sixty five angiographically diseased and non-diseased segments were analysed by quantitative coronary angiography. Mean lumen diameter and minimal lumen diameter were used as measures of diffuse and focal coronary atherosclerosis. Mean lumen diameter and minimum lumen diameter decreased by 0.02 and 0.03 mm per year. The rate of progression was similar in the angiographically non-diseased, as in the mildly and moderately diseased segments. Progression of diffuse coronary atherosclerosis was largest in severely stenosed lesions (percentage diameter stenosis > or = 50%) and in the right coronary artery with a loss of 0.19 mm and 0.16 mm in mean lumen diameter. Progression of focal disease was most prominent in new and mild lesions and the right coronary artery, with a decrease in minimum lumen diameter of 0.34 mm and 0.22 mm. In most subgroups, progression occurred gradually over time. On a per segment level, progression and the occurrence of new lesions occurred in 4.4% and 4.2%. Regression and disappearance of a lesions was found in 2.3% and 1.9%. On a per patient level, 36% were progressors, 12% had a mixed response, 36% were stable, and 16% were regressors. CONCLUSION: Diffuse and focal coronary atherosclerosis progressed at the same rate in the first and second 2 years in stenosed and non-stenosed segments. The rate of coronary atherosclerosis progression was small, but was higher for focal than for diffuse disease. A minority of lesions progressed and spontaneous regression was rare. [less ▲]

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See detailThe role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids.
El Ouahabi, A.; Thiry, Marc ULg; Pector, V. et al

in FEBS Letters (1997), 414(2), 187-92

We used a 32P-labeled pCMV-CAT plasmid DNA to estimate the DNA uptake efficiency and unlabeled pCMV-CAT plasmid DNA to quantify the CAT activity after transfection of COS cells using each of the three ... [more ▼]

We used a 32P-labeled pCMV-CAT plasmid DNA to estimate the DNA uptake efficiency and unlabeled pCMV-CAT plasmid DNA to quantify the CAT activity after transfection of COS cells using each of the three following cationic compounds: [1] vectamidine (3-tetradecylamino-N-tert-butyl-N'-tetradecylpropionamidine, and previously described as diC14-amidine [1]), [2] lipofectin (a 1:1 mixture of N-(1-2,3-dioleyloxypropyl)-N,N,N-triethylammonium (DOTMA) and dioleylphosphatidylethanolamine (DOPE)), and [3] DMRIE-C (a 1:1 mixture of N-[1-(2,3-dimyristyloxy)propyl]-N,N-dimethyl-N-(2-hydroxyethyl) ammonium bromide (DMRIE) and cholesterol). Surprisingly, a high CAT activity was observed with vectamidine although the DNA uptake efficiency was lower as compared to lipofectin and DMRIE-C. Transmission electron microscopy (TEM) revealed endocytosis as the major pathway of DNA-cationic lipid complex entry into COS cells for the three cationic lipids. However, the endosomal membrane in contact with complexes containing vectamidine or DMRIE-C often exhibited a disrupted morphology. This disruption of endosomes was much less frequently observed with the DNA-lipofectin complexes. This comparison of the three compounds demonstrate that efficient transfection mediated by cationic lipids is not only correlated to their percentage of uptake but also to their ability to destabilize and escape from endosomes. [less ▲]

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See detailLe médicament du mois - Le Valaciclovir (Zelitrex)
Pierard, Gérald ULg; Nikkels, Arjen ULg

in Revue Médicale de Liège (1997), 52(8), 553-555

Un progrès important vient d'être réalisé dans le traitement du zona. Le valaciclovir (Zelitrex) est un nouveau médicament oral qui est en fait un précurseur de l'aciclovir. Sa biodisponibilité supérieure ... [more ▼]

Un progrès important vient d'être réalisé dans le traitement du zona. Le valaciclovir (Zelitrex) est un nouveau médicament oral qui est en fait un précurseur de l'aciclovir. Sa biodisponibilité supérieure à celle de l'aciclovir est à l'origine d'un progrès thérapeutique majeur dans la prise en charge du zona cutané chez des sujets immunocompétents de plus de 50 ans et du zona ophtalmique quel que soit l'âge du sujet. Le valaciclovir réduit tant la prévalence que la sévérité des douleurs associées au zona. [less ▲]

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See detailLa survie des savoirs médiévaux dans la littérature populaire. Le rôle des incunables
Opsomer, Carmélia ULg

in Bulletin de la Société des Bibliophiles liégeois (1997), 23

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See detailTiming effect of combined radioimmunotherapy and radiotherapy on a human solid tumor in nude mice.
Coucke, Philippe ULg; Lin-Quan, Sun; Vogel, Charles-André et al

in Cancer Research (1997), 57

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were ... [more ▼]

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were evaluated separately. Then, 30 Gy RT (10 fractions over 12 days) were combined with three weekly Lv. injections of 200 g@Ci of 131I-labeled anti-carcino embryonic antigen monoclonal antibodies in four different treatment schedules. RIT was given either prior to, concurrently, Immediately after, or 2 weeks after RT administration. The longest regrowth delay (RD) of 105 days was observed in mice treated by concurrent administration of RT and lilT, whereas the RDs of RT and RIT alone were 34 and 20 days, respectively. The three sequential combination treatments produced sig nificantly shorter RDs ranging from 62 to 70 days. The tumor response represented by the minimal volume (MV) also showed that concurrent administration of RT and RIT gave the best result, with a mean MV of 4.5% as compared to MVs from 26 to 53% for the three sequential treatments. The results were confirmed In a second experiment, In which a RT of 40 Gy was combined with an identical lilT as above (three injections of 200 g&Ci of ‘31I-labeled monoclonal antibodies). At compa rable toxicity levels, the maximum tolerated RT or BIT alone gave shorter RDs and less tumor shrinkage compared to slinultaneous RT+RIT. These results may be useful for designing clinical protocols ofcombined RIT and RT. [less ▲]

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See detailDopamine 'D2-like' receptor agonists in combination with cocaine: absence of interactive effects on locomotor activity.
Tirelli, Ezio ULg; Reggers, Jean ULg; Terry, P.

in Behavioural Pharmacology (1997), 8(2-3), 147-59

This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in ... [more ▼]

This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measured by photobeam crossings over 140 min. At the doses given (7-OH-DPAT: 0.006-6.4 mg/kg; quinpirole: 0.001-1 mg/kg; RU24213: 0.008-8 mg/kg) all three direct agonists dose-dependently reduced locomotor activity throughout the test, whereas cocaine (0.6-20 mg/kg) produced dose-related hyperactivity. Next, for each direct agonist, a series of doses was selected (up to threshold behaviourally-active doses) as pretreatments to a sub-maximally stimulant dose of cocaine (15 mg/kg). 7-OH-DPAT and quinpirole did not modulate the effects of cocaine; RU24213 produced, at best, a very modest attenuation of the effects of cocaine. Finally, a series of cocaine doses (below stimulant threshold) was given before a single dose of each direct agonist (the lowest dose to reduce activity significantly). Cocaine did not reliably alter the hypoactivity produced by any of the D2-like agonists. By demonstrating negligible interactions between cocaine and D2-like agonists, the results fail to demonstrate any necessary involvement of D2-like receptors in one of the behavioural effects of cocaine. [less ▲]

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See detailPolymorphous light eruption-like lesions on sun-protected injection sites of recombinant IFN-alpha-2b
Nikkels, Arjen ULg; Delwaide, Jean ULg; Letawe, C. et al

in Journal of Dermatological Treatment (1997), 8(4), 285

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See detailRegular compactly supported wavelets in Sobolev spaces
Bastin, Françoise ULg; Laubin, P.

in Duke Mathematical Journal (1997), 87(3), 481-508

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See detailChanges in the Western Boundary Undercurrent outflow since the Last Glacial Maximum, from smectite/illite ratios in deep Labrador Sea sediments
Fagel, Nathalie ULg; Hillaire-Marcel; Robert, Christian

in Paleoceanography (1997), 12(1), 79-96

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador ... [more ▼]

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador Rise) of the Western Boundary Undercurrent (WBUC) gyre. At the two sites, smectites transported from the eastern Iceland and Irminger basins by the WBUC are observed. Clay mineral changes are used as proxies for the paleointensity reconstruction of the WBUC. On the Greenland Rise, a clay mineral index (smectite/illite (S/I) ratio) is defined. A S/I ratio of similar to 1 characterized the Last Glacial Maximum. It increased after similar to 17 ka, and reached a maximum value of 4 during the early Holocene, The mineralogical changes are gradual and do not show any reversal during the Younger Dryas, This pattern, which is confirmed by first-order estimations of smectite and illite fluxes, suggests gradually increasing sedimentary fluxes and WBUC intensity since the Last Glacial Maximum, A peak in the velocity of the WBUC at similar to 9 ka, as recorded by clay assemblages, is consistent with other regional studies based on pollen, foraminifera, or grain-size measurements, A massive dilution of smectites by illite and chlorite (S/I approximate to 3) occurs at similar to 8.5 ka. It corresponds to a period of rapid sediment accumulation and reflects an intensified illite-rich detrital supply by meltwaters from the southern Greenland Ice Margin. On the Labrador Rise, the smectite content varies between 20 and 60% with no obvious trend through time. The mineralogical composition is strongly influenced by ice-rafted deposition and by the abundance of fast deposit units (cf, Heinrich layers in the North Atlantic) which contain abundant detrital carbonates spilled-over from the North-West Atlantic Mid-Ocean Channel. In such layers, smectites are present but are diluted by the addition of illites, chlorites, and kaolinites. This provides evidence for a discrete and continuous WBUC supply of fine particles from the Irminger and Iceland Basins as far as the southeastern part of the Labrador Basin, Early deglacial smectite-rich layers (up to 60%) are also observed at this site, They indicate an increase in the outflow of the WBUC at similar to 13.5 ka, (Bolling-Allerod), as previously reported from grain size or foraminiferal assemblage studies. [less ▲]

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See detailMechanisms of cancer-related anemia and rationale for erythropoietin treatment
Beguin, Yves ULg

in Cancer Biotherapy (1997), 1

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See detailCalibration of a finite element model for bolted endplate steel connections
Bursi, O.; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (1997), 44(No 3), 225-262

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See detailThe Major Homology Region Of Bovine Leukaemia Virus P24(Gag) Is Required For Virus Infectivity In Vivo
Willems, Luc ULg; Kerkhofs, P.; Attenelle, L. et al

in Journal of General Virology (1997), 78

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