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See detailAtheroemboles et chirurgie cardiaque: importance de la mise au point préopératoire
Kolh, Philippe ULg; Torchiana, D.; Buckley, M.

in Revue Médicale de Liège (1999), 54(1), 43-8

OBJECTIVE: Atheroembolization is a recognized complication of cardiac surgical procedures, and has been implicated in postoperative stroke, renal failure, multiorgan failure, and death. Preoperative ... [more ▼]

OBJECTIVE: Atheroembolization is a recognized complication of cardiac surgical procedures, and has been implicated in postoperative stroke, renal failure, multiorgan failure, and death. Preoperative identification of patients at risk for developing atheroemboli is essential. The aim of this study was to determine preoperative risk factors for atheroemboli and to assess the postoperative course of the patients who developed atheroembolic syndrome. METHODS: A retrospective record review was conducted. From 1/1990 to 12/1994, 5.486 patients underwent coronary artery bypass grafting (CABG), valve operations, or other cardiac surgical procedures at the Massachusetts General Hospital. Among this population, 107 patients (1.9%) developed atheroembolic syndrome. There were compared to a concurrent population of 925 patients operated during the same period. RESULTS: Patients who developed atheroemboli were older, with an increased incidence (p < 0.01) of hypertension, cerebrovascular disease, and aortoiliac disease. Many had a complicated course after catheterization, with renal insufficiency (35%) and evidence of peripheral emboli (12%). Average Intensive Care Unit stay, hospital stay, and hospital cost of these patients were 16.8 days, 48.4 days and 88,000 respectively, compared to 1.5 days, 9.6 days and 23,000 for the concurrent population. Of these 107 patients only two were discharged home, the others either died (48 patients, or 25% of all cardiac surgical deaths during this period), or rehabilitation or chronic hospital facilities. Twenty-seven autopsies were performed and invariably showed a diffusely diseased aorta, with calcification, mural thrombus, and ulceration. CONCLUSIONS: Atheroembolization during cardiac surgical procedures has profound medical and economic consequences. Because of the diffuse nature of aortic disease, measures approaching the disease as a local process are likely to be unsuccessful. Appropriate evaluation would ideally identify patients with extensive aortic atheromatous disease, prior to rather than during surgery. [less ▲]

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See detailRegional brain activity during tasks devoted to the central executive of working memory
Collette, Fabienne ULg; Salmon, Eric ULg; Van der Linden, Martial ULg et al

in Cognitive Brain Research (1999), 7(3), 411-417

Most previous PET studies investigating the central executive (CE) component of working memory found activation in the prefrontal cortex. However, the tasks used did not always permit to distinguish ... [more ▼]

Most previous PET studies investigating the central executive (CE) component of working memory found activation in the prefrontal cortex. However, the tasks used did not always permit to distinguish precisely the functions of the CE from the storage function of the slave systems. The aim of the present study was to isolate brain areas that subserve manipulation of information by the CE when the influence of storage function was removed. A PET activation study was performed with four cognitive tasks, crossing conditions of temporary storage and manipulation of information. The manipulation of information induced an activation in the right (BA 10/46) and left (BA 9/6) middle frontal gyrus and in the left parietal area (BA7). The interaction between the storage and manipulation conditions did not reveal any significant changes in activation. These results are in agreement with the hypothesis that CE functions are distributed between anterior and posterior brain areas, but could also reflect a simultaneous involvement of controlled (frontal) and automatic (parietal) attentional systems. In the other hand, the absence of interaction between the storage and manipulation conditions demonstrates that the CE is not necessarily related to the presence of a memory load. [less ▲]

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See detailComment j'explore ... une pneumopathie interstitielle diffuse
Bury, Thierry ULg

in Revue Médicale de Liège (1999), 54(1), 54-7

There are a large number of conditions of known or unknown causes that have a tendency to alveolar wall fibrosis. The patient usually presents with progressive dyspnoea and the chest radiograph shows ... [more ▼]

There are a large number of conditions of known or unknown causes that have a tendency to alveolar wall fibrosis. The patient usually presents with progressive dyspnoea and the chest radiograph shows bilateral shadows whereas physiological measurements show a restrictive defect. Because of implications with regard to treatment and prognosis, diagnosis and staging of the disease are important. Computed tomography ("high resolution") and bronchoalveolar lavage are very useful at all stages of management of interstitial lung disease. [less ▲]

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See detailMorphometrical study of the equine navicular bone: age-related changes and influence of exercise
Gabriel, Annick ULg; Detilleux, Johann ULg; Jolly, Sandra ULg et al

in Veterinary Research Communications (1999), 23(1), 15-40

Navicular bones from the four limbs of 95 horses, classified in 9 categories, were studied. The effects of age on navicular bone morphometry and histomorphometry were estimated, after adjustment of the ... [more ▼]

Navicular bones from the four limbs of 95 horses, classified in 9 categories, were studied. The effects of age on navicular bone morphometry and histomorphometry were estimated, after adjustment of the data to even out the effects of front and rear limbs, morphometrical type, sex, weight, and size. All the external measurements of the navicular bone decreased significantly with increasing age. From the histomorphometrical data, cortical bone volume decreased with age in most horses, whereas cancellous bone volume and, in particular, the marrow spaces increased. The increase in the cancellous bone volume could have resulted from tunnelling of the internal part of the cortex, which converted it progressively into a porous trabecular-like structure. Trabecular bone volume also decreased with age and the trabecular lattice changed dramatically to become disconnected in aged horses. These observations corresponded closely to those reported for ageing of the skeletal system in humans. However, in sporting horses, the navicular cortical bone volume increased with age and the cancellous bone volume decreased. Exercise appeared to have decreased bone resorption and increased bone formation at the endocortical junction. The cancellous bone architecture was also improved. in that the trabecular lattice and trabecular bone volume remained unchanged in aged sporting horses. Our findings confirmed that exercise may be good practice to prevent age-related bone loss. [less ▲]

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See detailAnalysis of Endotoxin Effects on the Intact Pulmonary Circulation
Lambermont, Bernard ULg; Kolh, Philippe ULg; Detry, Olivier ULg et al

in Cardiovascular Research (1999), 41(1), 275-81

OBJECTIVE: The mechanism of sustained alterations in pulmonary hemodynamics during endotoxin shock remains unclear. To gain more detailed knowledge we used the four-element windkessel model as a ... [more ▼]

OBJECTIVE: The mechanism of sustained alterations in pulmonary hemodynamics during endotoxin shock remains unclear. To gain more detailed knowledge we used the four-element windkessel model as a descriptor of the pulmonary circuit. METHODS: Consecutive changes in characteristic resistance (R1), vascular compliance (C), input resistance (R2) and inductance (L) were continuously assessed following injection of endotoxin in 6 anaesthetised pigs, and were compared with the corresponding values measured in a similar group of sham-operated animals. RESULTS: Endotoxin challenge resulted in a biphasic pulmonary artery pressure response. Blood flow decreased progressively from 2.8 +/- 0.2 l/min to 2 +/- 0.2 l/min. Ohmic pulmonary vascular resistance (PVR) increased gradually from 0.2 +/- 0.04 to 0.76 +/- 0.1 mm Hg s ml-1. The early increase in PAP (from 14 +/- 2 to 27 +/- 4 mm Hg) was mediated by changes in both R1 (from 0.04 +/- 0.01 to 0.06 +/- 0.01 mm Hg s ml-1) and R2 (from 0.16 +/- 0.04 to 0.61 +/- 0.2 mm Hg s ml-1). These responses, in turn, altered the proximal vascular compliance. A subsequent increase in PAP (from 27 +/- 2 to 32 +/- 3 mm Hg) paralleled the specific decline in distal pulmonary vasculature compliance from 0.84 +/- 0.1 to 0.65 +/- 0.1 ml/mmHg. Analysis of the time course of PVR did not allow us to distinguish between vasoconstriction and stiffening of the vascular tree as mechanisms accounting for PAP changes. CONCLUSIONS: Endotoxemia leads to pulmonary hypertension, which is a result of constriction of proximal pulmonary arteries during the early phase, whereas the late phase is characterised by a decline in distal pulmonary vasculature compliance. [less ▲]

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See detailLes tumeurs malignes d'origine indéterminée
Rezaei Kalantari, Hassan ULg; Jerusalem, Guy ULg; Bours, Vincent ULg et al

in Revue Médicale de Liège (1999), 54(1), 39-42

Cancers of unknown origin form a specific clinical entity. The diagnostic procedure has to be guided by the therapeutical possibilities and requires a biopsy. Immunohistology, electron microscopy and ... [more ▼]

Cancers of unknown origin form a specific clinical entity. The diagnostic procedure has to be guided by the therapeutical possibilities and requires a biopsy. Immunohistology, electron microscopy and cytogenetics are informative for carcinomas and poorly differentiated adenocarcinomas. The clinical status and the histology allow the definition of groups of patients who can benefit from a specific therapy and have a better prognosis. For the other patients, the prognosis is severe and there is no efficient therapy available. Such tumors are usually characterized by a very aggressive behaviour. [less ▲]

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See detailWhole-Body 18f-Fdg Pet for the Evaluation of Patients with Hodgkin's Disease and Non-Hodgkin's Lymphoma
Jerusalem, Guy ULg; Warland, V.; Najjar, F. et al

in Nuclear Medicine Communications (1999), 20(1), 13-20

Whole-body metabolic information provided by 18F-FDG PET could help in the evaluation of lymphoma patients at diagnosis and follow-up. We studied 60 patients, 42 at initial presentation and 18 for disease ... [more ▼]

Whole-body metabolic information provided by 18F-FDG PET could help in the evaluation of lymphoma patients at diagnosis and follow-up. We studied 60 patients, 42 at initial presentation and 18 for disease recurrence (23 aggressive non-Hodgkin's lymphoma, 21 low-grade non-Hodgkin's lymphoma and 16 Hodgkin's disease). All patients underwent a clinical examination, computed tomography (CT) and a non-attenuated PET scan within 1 week. The patients received 222-296 MBq (6-8 mCi) 18F-FDG intravenously and emission scans were recorded 45-90 min later. 18F-FDG PET detected more lymph nodes than the clinical examination or CT, but this rarely resulted in upstaging (two patients). The concordance between PET and CT for the evaluation of the spleen, liver and digestive tract was quite good. Discordance was noted in 12 patients for the evaluation of bone marrow infiltration, but confirmation by MRI or focal biopsy was not always obtained. We conclude that non-attenuated 18F-FDG PET is an easy and efficient whole-body method for the evaluation of patients with lymphomas. Compared with conventional techniques, however, it does not appear to offer much improvement for staging but provides a satisfactory base for follow-up. [less ▲]

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See detailCardiovascular Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade, by Metrenperone, in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Veterinary Journal (1999), 157(1), 31-37

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and ... [more ▼]

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and pulmonary hypertension were the major changes elicited by 5-HT. The purpose of the present study was to determine whether the cardiovascular response to 5-HT in calves was attributable to 5-HT2 receptors. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg) was administered intramuscular to six unsedated Friesian calves 30 min before the animals were given a 5-min intravenous 5-HT infusion. Mean systemic arterial (SAP), mean pulmonary arterial (PAP), pulmonary capillary wedge (PW) pressures were obtained by means of fluid-filled catheters, and cardiac output (CO) was measured by the thermodilution technique. Heart rate, stroke volume, systemic (SVR) and pulmonary (PVR) vascular resistances were calculated. Administration of 5-HT after metrenperone induced a short-lasting period of severe bradycardia followed by tachycardia and increased CO. The systemic blood pressure response was exclusively hypotensive and associated with a decrease in SVR. Conversely, PAP, PW, and PVR were not modified by 5-HT administration. The results establish that 5-HT induced systemic as well as pulmonary hypertension is mediated through the activation of type-2 serotonergic or alpha-adrenergic receptors, or both. In contrast, neither apnoea, bradycardia and hypotension, nor the positive chronotropic effect induced by 5-HT in cattle are mediated through such receptors. [less ▲]

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See detailJames W. Carey, McLuhan : généalogie et descendance d'un paradigme
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailRuth & Elihu Katz, D'où venait-il, où a-t-il disparu ?
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailPreliminary classification of the bovine respiratory complex into different levels of severity
Coghe, Joost; Uystepruyst, Christophe; Bureau, Fabrice ULg et al

in Bovine Practitioner (1999), 33(1), 85-87

Despite prophylactic measures, mainly including vaccination programs and management measures, respiratory disease remains the major cause of economic losses in the bovine species. Choice of treatment is ... [more ▼]

Despite prophylactic measures, mainly including vaccination programs and management measures, respiratory disease remains the major cause of economic losses in the bovine species. Choice of treatment is currently mainly based on the clinicians' personal experience. A theoretical method has been proposed earlier to classify this syndrome into four grades of severity : Grade 1, subclinical disease (no treatment); Grade 2, compensated clinical disease (antibiotics only); Grade 3, noncompensated clinical disease (antibiotics + anti inflammatory drugs); and Grade 4, irreversible clinical disease (no treatment). In order to realize this theoretical classification under field conditions, three techniques, each one evaluating the oxygen transport chain at a différent level, have been studied and validated, i.e. pulse oximetry, lactate dosage and the lobeline test. Afterwards, measurements were performed on calves suffering from acute respiratory disease and a preliminary classification was established. This novel approach could orientate and economize therapeutic strategies in bovine respiratory disease. [less ▲]

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See detailCardiac Troponin I and Troponin T: Recent Players in the Field of Myocardial Markers
Chapelle, Jean-Paul ULg

in Clinical Chemistry & Laboratory Medicine (1999), 37(1), 11-20

The troponin (Tn) complex consists of three subunits referred to as TnT, TnI and TnC. Myocardium contains TnT and TnI isoforms which are not present in skeletal muscles and which can be separated from the ... [more ▼]

The troponin (Tn) complex consists of three subunits referred to as TnT, TnI and TnC. Myocardium contains TnT and TnI isoforms which are not present in skeletal muscles and which can be separated from the muscular isoforms by immunological techniques. Using commercially available immunoassays, clinical laboratories are able to determine cardiac TnT and TnI (cTnT and cTnI) quickly and reliably as classical cardiac markers. After acute myocardial infarction, cTnT and cTnI concentrations start to increase in serum in a rather similar way than CK-MB, but return to normal after longer periods of time (approximately one week). Because of their excellent cardiac specificity, Tn subunits appear ideally suited for the differential diagnosis of myocardial and muscular damage, for example in noncardiac surgery patients, in patients with muscular trauma or with chronic muscular diseases, or after intense physical exercise. cTnT and cTnI may also be used for detecting evidence of minor myocardial damage: therefore they have found new clinical applications, in particular risk stratification in patients with unstable angina. In spite of the possible reexpression of cTnT in human skeletal muscles, and of the lack of standardization of cTnI assays, Tn subunits are not far to meet the criteria of ideal markers for acute myocardial injury. Only an insufficient sensitivity in the first hours following the acute coronary syndroms requiries to maintain an early myocardial marker in the cardiac panel for routine laboratory testing. [less ▲]

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See detailL'image du mois. Kyste hydatique hépatique
Radermecker, Régis ULg; Nkoghe, D.; Labasse, J. M. et al

in Revue Médicale de Liège (1999), 54(1), 4-5

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See detailLa transmission du virus de l’hépatite C en milieu hospitalier
Delwaide, Jean ULg; Gerard, Christiane ULg; Belaiche, Jacques ULg et al

in Médecine et Hygiène (1999), 57

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See detailFourfold basal plane anisotropy of the nonlocal magnetization of YNi2B2C
Civale, L.; Silhanek, Alejandro ULg; Thompson, J. R. et al

in Physical Review Letters (1999), 83(19), 3920-3923

Studies of single crystal YNi2B2C have revealed a fourfold anisotropy of the equilibrium maenetization in the square crystallographic basal plane. This pi/2 periodicity occurs deep in the superconductive ... [more ▼]

Studies of single crystal YNi2B2C have revealed a fourfold anisotropy of the equilibrium maenetization in the square crystallographic basal plane. This pi/2 periodicity occurs deep in the superconductive mixed state. In this crystal symmetry, an ordinary superconductive mass anisotropy (as in usual London theory) allows only a constant, isotropic response. In contrast, the experimental results are well described by generalized London theory incorporating nonlocal electrodynamics, as needed for this clean, intermediate-kappa superconductor. [less ▲]

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See detailHypertension arterielle et diabete de type 2.
Scheen, André ULg; Estrella, F.; Weekers, Laurent ULg

in Revue Médicale de Liège (1999), 54(10), 789-95

Diabetes mellitus is frequently associated with arterial hypertension and the combination of both entities markedly increases the vascular risk. In type 2 diabetes, hypertension appears very early ... [more ▼]

Diabetes mellitus is frequently associated with arterial hypertension and the combination of both entities markedly increases the vascular risk. In type 2 diabetes, hypertension appears very early, especially in the presence of obesity, is part of the insulin resistance syndrome, and contributes to high cardiovascular morbidity and mortality rates in this population. Appropriate regulation of blood pressure is crucial in order to reduce not only microangiopathy (nephropathy and retinopathy) but also macroangiopathy (coronary heart disease and stroke) in hypertensive type 2 diabetic patients. Target blood pressure values have been decreased in recent years and should be < 130/85 mmHg, and may be even lower according to recent data. The optimal modalities of pharmacological treatment remain controversial, but obviously several medications are required to reach such objectives in most hypertensive patients with type 2 diabetes. [less ▲]

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See detailContribution à l'étude de la flore des grottes de Belgique.
Garbacki, Nancy ULg; Ector, Luc; Kostikov, Igor et al

in Belgian Journal of Botany (1999), 132(1), 43-76

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See detailComment je traite ... une obesite severe et ses anomalies metaboliques par une gastroplastie.
Luyckx, Françoise ULg; Scheen, André ULg; Letiexhe, Michel ULg et al

in Revue Médicale de Liège (1999), 54(3), 138-42

Severe obesity, defined as a body mass index > or = 35 kg/m2, is frequently associated with various biological abnormalities, particularly in the presence of intra-abdominal adiposity. The most important ... [more ▼]

Severe obesity, defined as a body mass index > or = 35 kg/m2, is frequently associated with various biological abnormalities, particularly in the presence of intra-abdominal adiposity. The most important disorders belong to the so-called insulin resistance syndrome, metabolic syndrome or syndrome X: hyperinsulinaemia, impaired glucose tolerance or type 2 diabetes, dyslipidaemias, hyperuricaemia, hyperfibrinogenaemia. All these metabolic abnormalities are considered as cardiovascular risk factors. They are also correlated with the severity of the liver steatosis which is commonly observed in individuals with severe obesity. We report our experience of the evolution of these metabolic abnormalities after a marked weight loss induced by gastroplasty. We will analyse the favourable effects of bariatric surgery on insulin sensitivity, biological components of the metabolic syndrome, type 2 diabetes and liver steatosis. [less ▲]

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See detailNew Therapeutic options
Reginster, Jean-Yves ULg; Henrotin, Yves ULg

in Bone Depeche (1999), 5

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See detailMcLuhan, trente ans après
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailIntérêt de la tomographie à émission de positons dans l'évaluation des tumeurs gastro-intestinales
Rigo, Pierre ULg; Albérini, Jean-Louis; Hustinx, Roland ULg et al

in Acta Endoscopica (1999), 29(2), 129-138

La TEP au 18FDG présente de nombreuses indications dans l'évaluation des tumeurs digestives. Son rôle principal concerne le bilan d'extension des récidives tumorales démontrées ou suspectées mais des ... [more ▼]

La TEP au 18FDG présente de nombreuses indications dans l'évaluation des tumeurs digestives. Son rôle principal concerne le bilan d'extension des récidives tumorales démontrées ou suspectées mais des indications plus ponctuelles concernent évalement le diagnostic différentiel des masses pancréatiques et le bilan du cancer de l'oesophage. Le principal avantage de la TEP résulte de la nature métabolique du signal indépendant et complémentaire des modifications anatomiques visibles en imagerie classique. Un autre avantage est lié à l'examen du corps entier aujourd'hui pratiqué systématiquement. La TEP trouve dès lors sa place en première ligne dans ses différentes indications. [less ▲]

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See detailL'incontinence urinaire chez la femme agee.
Fillet, Marc ULg; Bonnet, Pierre ULg; de Leval, Jean ULg

in Revue Médicale de Liège (1999), 54(4), 341-8

Physical, psychological and economical consequences of urinary incontinence of the elderly woman are underestimated. It often results in depression, social isolation and early institutionalisation. It is ... [more ▼]

Physical, psychological and economical consequences of urinary incontinence of the elderly woman are underestimated. It often results in depression, social isolation and early institutionalisation. It is often the key factor that determines the decision of institutionalisation, which represent the most important part of the total cost of urinary incontinence. This problem is too often neglected and deserves considerable attention. [less ▲]

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See detailObjectifs scientifiques de la Section Heure, Rotation de la Terre et Géodésie Spatiale de l’Observatoire Royal de Belgique
Dehant, Véronique; Brondeel, Marijke; Bruyninx, Carine et al

in Ciel et Terre (1999), 115(3), 127-133

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See detailMorphologie, distribution et écologie comparées d'Amblystegium tenax et d'A. fluviatile en Belgique
Vanderpoorten, Alain ULg; Empain, Alain ULg

in Belgian Journal of Botany (1999), 132(1), 3-12

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See detailLa prescription de l'action délictuelle en droit du travail après la loi du 10 juin 1998
Kefer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (1999)

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See detailConvergence of High Order Curl-Conforming Finite Elements
Geuzaine, Christophe ULg; Meys, B.; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1442--1445

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See detailDiagnosis of myxomatosis by an indirect immunoperoxidase test
Marlier, Didier ULg; Boucraut-baralon, Corine; Vindevogel, Henri ULg

in Vlaams Diergeneeskundig Tijdschrift (1999), 68

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See detailComment j'explore ... une suspicion de sténose d'artère rénale
Krzesinski, Jean-Marie ULg; Turatzinze, Léopold

in Revue Médicale de Liège (1999), 54(8), 702-704

Renal artery stenosis can present 2 clinical pictures, sometimes associated and potentially treatable, due mainly to atherosclerosis, but also to fibromuscular dysplasia. The first possible presentation ... [more ▼]

Renal artery stenosis can present 2 clinical pictures, sometimes associated and potentially treatable, due mainly to atherosclerosis, but also to fibromuscular dysplasia. The first possible presentation is renovascular hypertension which represents 1% of unselected hypertensive populations. The second possible presentation is ischemic renal disease, which represent 10% of the new indications for dialysis therapy and has a 50% mortality rate at 3 years. To explore this disease, arteriography, the gold standard, must be reserved for confirmation and treatment. Hypertension induced by the stenosis is best approached by captopril renal MAG 3 scintigraphy. Measurement of the stenosis severity can be performed either by duplex ultrasonography, magnetic resonance angiography or spinal CT angiography according to patients'characteristics, local experience and facilities. This disease must be searched in the presence of renal insufficiency of unknown cause or refractory hypertension. [less ▲]

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See detailPerturbative evolution and Regge behaviour
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P. V.

in Physics Letters B (1999), 448

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See detailAvantages des nouveaux traitements contre les puces et les tiques
Delaunois, A.; Gustin, Pascal ULg

in Pharma-Sphère (1999), 30

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See detailLes mouvements Maï Maï de la République Démocratique du Congo. D'où viennent-ils et qui sont-ils?
Kabamba, Bob ULg

in International Documentation Network on the Great African Lakes Region (1999)

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See detailFrom a New-World Poetics to a New-World Vision: African America in the Works of Edouard Glissant and Caryl Phillips
Ledent, Bénédicte ULg

in Commonwealth : Essays and Studies (1999), 21(2), 29-36

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See detailA Natural Method for Coupling Magnetodynamic H-Formulations and Circuit Equations
Dular, Patrick ULg; Geuzaine, Christophe ULg; Legros, Willy ULg

in IEEE Transactions on Magnetics (1999), 35(3), 1626--1629

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See detailContribution of the carbohydrate moiety to conformational stability of the carboxypeptidase Y high pressure study.
Dumoulin, Mireille ULg; Ueno, H.; Hayashi, R. et al

in European Journal of Biochemistry (1999), 262(2), 475-83

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the ... [more ▼]

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the catalytic activity and, the intrinsic and 8-anilino-1-naphthalene sulfonic acid binding fluorescences. Pressure-induced denaturation of carboxypeptidase Y is a process involving at least three transitions. Low pressures (below 150 MPa) induced slight conformational changes characterized by a slight decrease in the center of the spectral mass of intrinsic fluorescence, whereas no changes in 8-anilino-1-naphthalene sulfonic acid binding fluorescence were observed and 80% of the catalytic activity remained. Higher pressure (150-500 MPa) induced further conformational changes, characterized by a large decrease in the center of the spectral mass of intrinsic fluorescence, a large increase in the 8-anilino-1-naphthalene sulfonic acid binding fluorescence and the loss of all catalytic activity. Thus, this intermediate exhibited characteristics of molten globule-like state. A further increase, in pressure (above 550 MPa) induced transition from this first molten globule-like state to a second molten globule-like state. This two-stage denaturation process can be explained by assuming the existence of two independent structural domains in the carboxypeptidase molecule. A similar three-transition process was found for unglycosylated carboxypeptidase Y, but, the first two transitions clearly occurred at lower pressures than those for glycosylated carboxypeptidase Y. These findings indicate that the carbohydrate moiety protects carboxypeptidase Y against pressure-induced denaturation. The origin of the protective effects is discussed based on the known crystallographic structure of CPY. [less ▲]

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See detailThe neural correlates of updating information in verbal working memory
Van der Linden, Martial ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Memory (1999), 7(5-6), 549-560

The aim of the present study was to re-examine cerebral areas subserving the updating function of the central executive with a running span task requiring subjects to watch strings of consonants of ... [more ▼]

The aim of the present study was to re-examine cerebral areas subserving the updating function of the central executive with a running span task requiring subjects to watch strings of consonants of unknown length and then to recall serially a specific number of recent items. In order to dissociate more precisely the updating process from the storage function, a four-item instead of a six-item memory load was used, contrary to our previous study (Salmon et al., 1996). In addition, a serial recall procedure was preferred to a recognition procedure in order to suppress the use of visuospatial strategies. The most significant increase of rCBF occurred in the left frontopolar cortex (Brodmann's area 10), spreading to the left middle frontal (Brodmann's area 46). Results suggest that frontopolar activation underlies an updating process in working memory. [less ▲]

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See detailConversion of green note aldehydes into alcohols by yeast alcohol dehydrogenase
Fauconnier, Marie-Laure ULg; Mpambara, A.; Delcarte, Jérôme et al

in Biotechnology Letters (1999), 21(7), 629-633

‘Green note’ aldehydes were successfully reduced into their corresponding alcohol by commercial yeast alcohol dehydrogenase. Among different yeasts tested for their ability to convert (Z)-3-hexenal into ... [more ▼]

‘Green note’ aldehydes were successfully reduced into their corresponding alcohol by commercial yeast alcohol dehydrogenase. Among different yeasts tested for their ability to convert (Z)-3-hexenal into (Z)-3-hexenol, Pichia anomala gave the best results. Conversion yields higher than 90% were also obtained by directly conducting the reaction in the medium where (Z)-3-hexenal is produced by the action of lipoxygenase and hydroperoxide lyase on <br />linolenic acid. [less ▲]

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See detailExploration isocinétique : analyse des courbes
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Annales de Réadaptation et de Médecine Physique (1999), 42

Introducition: La courbe isocinétique met en relation le moment de force développé et le positionnement articulaire: elle autorise l'étude in vivo de la relation classique tension-longueur. Le tracé ... [more ▼]

Introducition: La courbe isocinétique met en relation le moment de force développé et le positionnement articulaire: elle autorise l'étude in vivo de la relation classique tension-longueur. Le tracé isocinétique se caractérise occasionnellement par un profil anormal. Méthode: Sur la base de l'expérience clinique, les auteurs proposent une classification d'anomalies; plusieurs facteurs contribuent à leur apparition: une collaboration ou une familiarisation insuffisante du patient, un protocole inadéquat, une amyotrophie majeure, une modification de la biomécanique articulaire, des troubles neurologiques ainsi que des phénomènes algiques au cours de l'exercice. Discussion et conclusion: L'intérêt diagnostique des courbes isocinétiques ne semble pas crédible, comme l'indique une étude centrée sur la nature et la fréquence des anomalies dans différents groupes de lésions opérées ou non opérées du ligament croisé antérieur. Sous réserve d'une analyse rigoureuse, les implications rééducatives paraissent néanmoins intéressantes lorsqu'une anomalie reproductible de la courbe s'accompagne d'un phénomène algique. [less ▲]

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See detailConstraint-generating dependencies
Baudinet, Marianne; Chomicki, Jan; Wolper, Pierre ULg

in Journal of Computer & System Sciences (1999), 59(1), 94-115

Traditionally, dependency theory has been developed for uninterpreted data. Specifically, the only assumption that is made about the data domains is that data values can be compared for equality. However ... [more ▼]

Traditionally, dependency theory has been developed for uninterpreted data. Specifically, the only assumption that is made about the data domains is that data values can be compared for equality. However, data is often interpreted and there can be advantages in considering data as such, for instance, obtaining more compact representations as is done in constraint databases. This paper considers dependency theory in the context of interpreted data. Specifically, it studies constraint-generating dependencies. These are a generalization of equality-generating dependencies where equality requirements are replaced by constraints on an interpreted domain. The main technical results in the paper are a general decision procedure for the implication and consistency problems for constraint-generating dependencies and complexity results for specific classes of such dependencies over given domains. The decision procedure proceeds by reducing the dependency problem to a decision problem for the constraint theory of interest and is applicable as soon as the underlying constraint theory is decidable. The complexity results are, in some cases, directly lifted from the constraint theory; in other cases, optimal complexity bounds are obtained by taking into account the specific form of the constraint decision problem obtained by reducing the dependency implication problem. (C) 1999 Academic Press. [less ▲]

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See detailDroits de passage : une mise au point terminologique
Vanbrabant, Bernard ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (1999)

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See detailAtteintes physiopathologiques liees a la circulation extracorporelle. Pathogenies et modes de prevention
Defraigne, Jean-Olivier ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154(10-12), 381-91392-5

During heart surgery, several humoral cascades (coagulation, complement, kallicrein-kinin, cytokines, fibrinolysis) and several cell systems (platelets, neutrophils, endothelial cells, ...) are activated ... [more ▼]

During heart surgery, several humoral cascades (coagulation, complement, kallicrein-kinin, cytokines, fibrinolysis) and several cell systems (platelets, neutrophils, endothelial cells, ...) are activated. Numerous contributing factors have been reported: blood contact with foreign surfaces of the extracorporeal circuits, blood-air interface, lung and myocardial ischemia-reperfusion after unclamping, hypothermia, shear stresses, ... A post-perfusion syndrome may develop which include miscellaneous symptoms: coagulation disturbances and bleeding, neurological alterations, inflammatory syndrome, and, in extreme cases, multisystemic organ failure. Even if the present mortality of cardiac surgery is low, several approaches have been proposed to reduce such activations. They are based on changing in the circuit design, or in the composition of the luminal surfaces of the tubing and oxygenator, on improvement of the operative technique, and on modifications of the perfusion technique. Pharmacological agents are also used (anti-inflammatory drugs, corticoids, serine proteases inhibitor (aprotinin, ...). Nevertheless, the development of more biocompatible surfaces seems a promising goal. [less ▲]

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See detailLatest Devonian to Early Carboniferous biostratigraphy of Northern Brazil: an update.
Melo, JHG; Loboziak, S; Streel, Maurice ULg

in Bulletin du Centre de Recherches Elf Exploration Production (1999), 22(1), 13-33

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See detailRevised masses of alpha Centauri
Pourbaix, D.; Neuforge-Verheecke; Noels-Grötsch, Arlette ULg

in Astronomy and Astrophysics (1999), 344(1), 172-176

With the precise radial velocities lately published \cite{Murdoch-1993:b}, a simultaneous least-squares adjustment of all visual and spectroscopic observations of the alpha Centauri system is now possible ... [more ▼]

With the precise radial velocities lately published \cite{Murdoch-1993:b}, a simultaneous least-squares adjustment of all visual and spectroscopic observations of the alpha Centauri system is now possible and likely to yield some accurate information. Such an orbit determination leads to a mass ratio in agreement with the astrometric estimate of Kamper & Wesselink \cite*{Kamper-1978} but yields upward revisions of the distance and masses. We examine the effects these revisions on the evolutionary status of the system. [less ▲]

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See detailSeparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes.
Fillet, Marianne ULg; Bechet, Isabelle; Piette, Véronique et al

in Electrophoresis (1999), 20(9), 1907-15

The aim of the present work was to investigate the separation of nonsteroidal anti-inflammatory drugs (NSAIDs: niflumic acid, flufenamic acid, piroxicam, alclofenac, tiaprofenic acid, flurbiprofen ... [more ▼]

The aim of the present work was to investigate the separation of nonsteroidal anti-inflammatory drugs (NSAIDs: niflumic acid, flufenamic acid, piroxicam, alclofenac, tiaprofenic acid, flurbiprofen, suprofen, ketoprofen, naproxen, indomethacin, carprofen, indoprofen, sulindac) in capillary electrophoresis (CE) using completely nonaqueous systems. The influence of different parameters such as nature and proportion of organic solvent (methanol, acetonitrile, 2-propanol), apparent pH (ranging from 7 to 9) and temperature (ranging from 25 to 40 degrees C) on selectivity and migration times were studied systematically in an uncoated fused-silica capillary. A nonaqueous electrolyte made of 50 mM ammonium acetate - 13.75 mM ammonia in methanol proved to resolve 11 NSAIDs at 25 degrees C and 13 NSAIDs at 36 degrees C, both within 13 min and without a modifier besides the methanol itself. The same buffer containing 30% acetonitrile provides a satisfactory separation for 13 NSAIDs within 14 min at 25 degrees C. [less ▲]

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See detailIntervention sur quelques aspects économiques de la réforme
Jurion, Bernard ULg

in Revue de la Faculté de Droit de l'Université de Liège (1999)

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See detailAn Optimization Method for the Design of Physical and Maxwellian Absorbers
Meys, B.; Henrotte, F.; Geuzaine, Christophe ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1430--1433

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See detailEndogenous auxin and cytokinin levels in shoots of a nonrooting tobacco mutant
Faivre-Rampant, O.; Kevers, Claire ULg; Gaspar, Th

in Bulletin de la Societe Royale des Sciences de Liege (1999), 68(5-6), 318

[No abstract available]

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See detailLe langage à l'envers
Steinmetz, Rudy ULg

in Louvain : Revue Mensuelle de l'Université Catholique de Louvain et de l'Association des Anciens et Amis de l'UCL (1999)

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See detailLe point de vue de l'économiste
Jurion, Bernard ULg

in La nouvelle procédure fiscale, Commision Université-Palais (1999), XXX(II), 99-108

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See detailStructure of high-temperature fluid selenium
Raty, Jean-Yves ULg; Saul, A.; Gaspard, Jean-Pierre ULg et al

in Physical Review. B : Condensed Matter (1999), 60(4), 2441-24482448

A semiempirical tight-binding energy model is developed for selenium. It includes s and p electrons as well as an empirical description of the dispersion forces that proves necessary at the liquid ... [more ▼]

A semiempirical tight-binding energy model is developed for selenium. It includes s and p electrons as well as an empirical description of the dispersion forces that proves necessary at the liquid densities under study. The band-structure parameters are obtained by fitting abinitio calculations. The simulated liquid structures are in very good agreement with the most recent X-ray scattering and extended X-ray absorption fine-structure experiments in a broad temperature and density range. The Monte Carlo simulations performed show that the complex liquid structures observed result from the breaking and branching of the selenium chains. The total coordination number is shown to result from the balance between one-, two-, and threefold coordinated atoms. The role of these defects is discussed in relationship with the electrical conductivity of the liquid, i.e., the semiconductor-metal and metal-nonmetal transitions observed at high pressures [less ▲]

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See detailAre The Fusion Processes Involved In Birth, Life And Death Of The Cell Depending On Tilted Insertion Of Peptides Into Membranes?
Peuvot, J.; Schanck, A.; Lins, Laurence ULg et al

in Journal of Theoretical Biology (1999), 198(2), 173-81

Various peptide segments have been modeled as asymmetric amphipathic alpha-helices. Theoretical calculations have shown that they insert obliquely into model membranes. They have been named "tilted ... [more ▼]

Various peptide segments have been modeled as asymmetric amphipathic alpha-helices. Theoretical calculations have shown that they insert obliquely into model membranes. They have been named "tilted peptides". Molecular modeling results reported here also evidence the presence of tilted peptides in ADM-1 protein of Caenorhabditis elegans that may be involved in fusion events, in meltrin alpha, a protein implicated in myoblast fusion, in hemagglutinin of influenza virus, in the E2 glycoprotein of rubella virus, in the S protein of hepatitis B virus, in a subdomain of Ebola virus and in the malaria CS protein. Experimental results have indicated that tilted peptide fragments may be involved in cellular life events like sperm-egg fecondation, muscle development, protein translocation through signal sequences and cellular death caused by viral infection or parasite infestation. We speculate that membrane destabilization by these tilted peptides may be an important common step in life processes involving fusion phenomena. [less ▲]

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See detailDual Harmonic and Time Approaches for the Design of Microwave Devices
Meys, B.; Geuzaine, Christophe ULg; Henrotte, F. et al

in IEEE Transactions on Magnetics (1999), 35(3), 1829--1832

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See detailPurification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors.
Kannan, R.; Ruff, M.; Kochins, J. G. et al

in Protein Expression & Purification (1999), 16

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has been shown to be involved in malignant tumor progression and therefore represents an attractive therapeutical target. In order to screen for ST3 ... [more ▼]

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has been shown to be involved in malignant tumor progression and therefore represents an attractive therapeutical target. In order to screen for ST3 synthetic inhibitors, we have produced and purified the catalytic domain of ST3, matrilysin, stromelysin-2, and membrane type-1 MMP from inclusion bodies in a bacterial system. Our strategy allowed the purification of MMPs directly in the active form, thereby avoidingin vitroactivation. A total of 140,000 synthetic compounds from the Bristol-Myers Pharmaceutical Research Institute chemical deck were tested, using a substrate-based colorimetric enzymatic assay, in which ST3 activity was evaluated through its ability to cleave and inactivate α-1 proteinase inhibitor. One ST3 inhibitor belonging to the cephalosporin family of antibiotics was thereby identified. [less ▲]

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See detailCharacterizations by automorphism groups of some rank 3 buildings, III. Moufang-like conditions
Van Steen, Kristel ULg

in Geometriae Dedicata (1999), 74(3), 225-240

In this paper, we introduce the root-Moufang condition and the p-adic Moufang condition. We show that affine buildings of type (A) over tilde(2) satisfying the root-Moufang condition are Bruhat-Tits ... [more ▼]

In this paper, we introduce the root-Moufang condition and the p-adic Moufang condition. We show that affine buildings of type (A) over tilde(2) satisfying the root-Moufang condition are Bruhat-Tits buildings. Also, every rank 3 affine building satisfying the p-adic Moufang condition is a Bruhat-Tits building. We motivate the introduction of the new conditions by showing that all Bruhat-Tits (A) over tilde(2)-buildings satisfy the root-Moufang condition, and that the (A) over tilde(2)-buildings over a p-adic field also satisfy the p-adic Moufang condition. Another application of the p-adic Moufang condition is given in Part IV of this paper. [less ▲]

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See detailEffects of inhaled dry powderipratropium broide on reconvery from exercise of horses with COPD
Duvivier, Dominique Hannia; Bayly, Warwick M; Votion, Dominique ULg et al

in Equine Veterinary Journal (1999), 31(1), 20-24

The present study evaluated ventilatory, cardiovascular and metabolic parameters during recovery from strenuous exercise in horses suffering from a crisis of chronic obstructive pulmonary disease (COPD ... [more ▼]

The present study evaluated ventilatory, cardiovascular and metabolic parameters during recovery from strenuous exercise in horses suffering from a crisis of chronic obstructive pulmonary disease (COPD) and to determine whether ipratropium dry powder inhalation (DPI) before exercise has an effect on these parameters. When 6 saddle horses, affected with COPD, developed airway obstruction, they inhaled placebo and ipratropium (2400 pghorse), the order being randomly chosen. Pulmonary function tests were then recorded 15 min after inhalation. Following these tests, the horses underwent a strenuous treadmill exercise, followed by a ecovery period that consisted of a 10 min walk. Measurements were made at the first and tenth min of recovery. Respiratory flow, 0 2 and C02 fractions in the respired gas, pleural pressure changes and heart rate were recorded. Arterial and mixed venous blood samples were analysed or gas tensions, haemoglobin and plasma lactate concentrations. Oxygen consumption (Wz), C02 production, tidal volume, alveolar oxygen tension (PAOz), alveolar ventilation, the alveolar-pulmonary capillary oxygen difference ((A-a)dOz) and total pulmonary resistance (RL) were measured. The PA02 was the only parameter significantly improved during recovery following ipratropium DPI. This improvement was not accompanied by evidence of improvement of other ventilatory or cardiorespiratory parameters. The results showed that in horses suffering from a crisis of COPD, recovery is characterised by an exercise-induced bronchodilation. Secondly, ipratropium DPI at a dose of 2400 pghorse is an effective bronchoddator in these horses at rest but it has little effect on the airway calibre during the recovery period. It is suggested that the short term recovery period is still Muenced by exercise-induced adjustments that may exceed the bronchodilatory effect of inhaled ipratropium that are observed before exercise [less ▲]

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See detailTibère et l'astrologie (Suétone, Vie de Tibère, 36 et 69)
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1999), 58

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See detailMise au point de pains composites à base de mélanges de farines de sorgho/blé et analyse texturale.
Balla, A.; Blecker, Christophe ULg; Oumarou, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(2), 69-77

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See detailThiazolidinediones.
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (1999)

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See detailSevere/extreme obesity: a medical disease requiring a surgical treatment?
Scheen, André ULg; Luyckx, Françoise ULg; Desaive, Claude ULg et al

in Acta Clinica Belgica (1999), 54(3), 154-61

Obesity poses a serious health hazard and its treatment is often disappointing. Surgical approaches have been proposed for treating severe obesity (body mass index or BMI > or = 35 kg/m2) with ... [more ▼]

Obesity poses a serious health hazard and its treatment is often disappointing. Surgical approaches have been proposed for treating severe obesity (body mass index or BMI > or = 35 kg/m2) with comorbidities or extreme obesity (BMI > or = 40 kg/m2). Before accepting bariatric surgery as alternative treatment, the four following prerequisites should be met: 1. the medical condition is serious enough; 2. it can not be treated satisfactorily with classical means; 3. the surgical treatment is effective in improving the clinical situation; and 4. bariatric surgery is safe enough, so that the benefits clearly outweigh the risks. On the basis of the literature and our own experience, it appears that gastric reduction surgery may be considered as a valuable alternative for treating severe/extreme obesity, despite the possible occurrence of perioperative and, more frequently, late complications, provided that it is performed by an experienced and multidisciplinary team in well-selected patients. [less ▲]

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See detailViaticum = facultas
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1999), 58

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See detailTransport properties of bulk-bicrystal grain boundaries in artificially joined large-grain YBCO
Bradley, A. D.; Doyle, R. A.; Charalambous, D. et al

in IEEE Transactions on Applied Superconductivity (1999), 9(2), 2038-2041

A technique for joining large-grain YBCO has been used to produce bulk-bicrystal grain boundaries of different orientations. The behaviour of boundaries nominally of 0 degrees[100], 0 degrees[001] and ... [more ▼]

A technique for joining large-grain YBCO has been used to produce bulk-bicrystal grain boundaries of different orientations. The behaviour of boundaries nominally of 0 degrees[100], 0 degrees[001] and asymmetric 15 degrees[100]-tilt misorientation have been investigated using low frequency transport measurements in fields up to 7T. The boundaries exhibit a metallic normal state and a superconducting transition which broadens with increasing field having an irreversibility line which closely matches that of the adjoining grains. This same qualitative behaviour is seen in all the samples measured for field applied parallel and perpendicular to the c-axis and up to the highest current densities employed (20 Acm(-2)). Variation between the different samples due to microstructural differences are discussed. We interpret these results as strong suggestive evidence that this joining technique can be used to produce strongly-coupled large-grains for bulk-scale engineering applications. [less ▲]

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See detailL’ostéoporose chez la personne âgée
Reginster, Jean-Yves ULg; Taquet, AN; Fraikin, G

in Medi-Sphere (1999), 103

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See detailS/SL/PPV : le prix de l'information du futur
Jérôme, Simone

in Cahiers de la Documentation = Bladen voor Documentatie (1999), (1), 3-25

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See detailIntragranular and intergranular superconducting properties of bulk melt-textured YBCO
Vanderbemden, Philippe ULg; Cloots, Rudi ULg; Ausloos, Marcel ULg et al

in IEEE Transactions on Applied Superconductivity (1999), 9(2), 2308-2311

We have investigated the superconducting properties of bulk melt-processed YBCO using different experimental techniques. First, single domain materials (i.e. containing no grain boundaries) have been ... [more ▼]

We have investigated the superconducting properties of bulk melt-processed YBCO using different experimental techniques. First, single domain materials (i.e. containing no grain boundaries) have been studied. Electrical resistivity, current-voltage characteristics, M-H loops, and A,C. susceptibility. have been measured for different field and current directions. The intragranular properties are characteristic of high-quality melt-processed YBCO material,,vith a critical current density J(c)(T=77K, B=1T//c) > 10(4) A/cm(2). The anisotropy ratio J(c)(ab)/ J(c)(c) is found to be close to 3. Both magnetic and transport measurements show that defects in the microstructure do not significantly impede the current flow inside the single domain. These results were compared to those measured on samples containing one "natural" single grain boundary which sometimes appears during the grain growth process. The intergranular properties show a much stronger current and magnetic field dependence than that measured within the grain and these differences are discussed. [less ▲]

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See detailSur philellên chez Cicéron
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1999), 68

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See detailCalcul et conception économique des assemblages de profilés reconstitués soudés
Braham, M.; Cerfontaine, F.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1999), (N°1), 5-24

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See detailTwo new aminopeptidases from Ochrobactrum anthropi active on D-alanyl-p-nitroanilide.
Fanuel, L; Thamm, Iris ULg; Kostanjevecki, V et al

in Cellular and Molecular Life Sciences : CMLS (1999), 55(5), 812-8

Two new enzymes which hydrolyse D-alanyl-p-nitroanilide have been detected in Ochrobactrum anthropi LMG7991 extracts. The first enzyme, DmpB, was purified to homogeneity and found to be homologous to the ... [more ▼]

Two new enzymes which hydrolyse D-alanyl-p-nitroanilide have been detected in Ochrobactrum anthropi LMG7991 extracts. The first enzyme, DmpB, was purified to homogeneity and found to be homologous to the Dap protein produced by O. anthropi SCRC C1-38 (ATCC49237). The second enzyme, DmpA, exhibits a similar substrate profile when tested on p-nitroanilide derivatives of glycine and L/D-alanine, but the amounts produced by the Ochrobactrum strain were not sufficient to allow complete purification. Interestingly, the DmpA preparation also exhibited an L-aminopeptidase activity on the tripeptide L-Ala-Gly-Gly but it was not possible to be certain that the same protein was responsible for both p-nitroanilide and peptide hydrolysing activities. The gene encoding the DmpA protein was cloned and sequenced. The deduced protein sequence exhibits varying degrees of similarity with those corresponding to several open reading frames found in the genomes of other prokaryotic organisms, including Mycobacteria. None of these gene products has been isolated or characterised, but a tentative relationship can be proposed with the NylC amidase from Flavobacterium sp. K172. [less ▲]

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See detailUne justice pénale européenne après Amsterdam
Flore, Daniel ULg

in Journal des Tribunaux Droit Européen (1999)

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See detailEvolution of organic debris and palynomorph preservation in two late middle Frasnian sections, southern Dinant Synclinorium border, Belgium
Vanguestaine, M.; Pardo-Trujillo, A.; Coen-Aubert, M. et al

in Bollettino della Società Paleontologica Italiana (1999), 38(2-3), 317-330

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See detailLe trésor des reliques de l'abbaye Saint-Hubert en Ardenne
George, Philippe ULg

in Études & Documents de la Région Wallonne. Monuments & Sites (1999)

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See detailPharma-clinics le medicament du mois. L'orlistat (xenical).
Scheen, André ULg; Ernest, Philippe ULg; Letiexhe, Michel ULg

in Revue Médicale de Liège (1999), 54(3), 192-6

Orlistat (tetrahydrolipstatin), launched by Roche under the trade name Xenical, is a selective inhibitor of pancreatic and gastro-intestinal lipases. It reduces the digestion of dietary fat and its ... [more ▼]

Orlistat (tetrahydrolipstatin), launched by Roche under the trade name Xenical, is a selective inhibitor of pancreatic and gastro-intestinal lipases. It reduces the digestion of dietary fat and its resorption through digestive mucosa by around 30%. It is indicated, at a dose of 3 x 120 mg/day (one dose with each meal) and together with a moderately low-calorie and low-fat diet, for the treatment of obesity. It has been shown, in placebo-controlled two-year trials, to almost double the number of obese subjects who succeed in loosing at least 10% of initial body weight. Independently, it contributes to decrease serum cholesterol levels by 6-10%. Because of its mechanism of action, this drug can induce intestinal side-effects which tend to decrease with time and with the reduction of fat intake, thus improving diet compliance. [less ▲]

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See detailDeactivation mechanisms and regeneration of a bimetallic hydrodechlorination catalyst
Heinrichs, Benoît ULg; Noville, Francis ULg; Schoebrechts, Jean-Paul et al

in Studies in Surface Science and Catalysis (1999), 126

The temporal evolution of the activity and selectivity of a 1.9%Pd-3.7%Ag/SiO2 catalyst during selective hydrodechlorination of 1,2-dichloroethane into ethylene is examined. A comparison between the ... [more ▼]

The temporal evolution of the activity and selectivity of a 1.9%Pd-3.7%Ag/SiO2 catalyst during selective hydrodechlorination of 1,2-dichloroethane into ethylene is examined. A comparison between the physico-chemical properties of the fresh catalyst and of the deactivated one suggests a deactivation mechanism by poisoning or coking of Ag sites at the surface of the active Pd-Ag particles. A regeneration treatment is proposed which allows to restore the initial properties of the fresh catalyst. [less ▲]

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See detailTroglitazone: antihyperglycemic activity and potential role in the treatment of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabetes Care (1999), 22(9), 1568-77

Insulin resistance is a major component of type 2 diabetes; therefore, an insulin sensitizer agent like the thiazolidinedione compound troglitazone is considered a very promising drug. Troglitazone exerts ... [more ▼]

Insulin resistance is a major component of type 2 diabetes; therefore, an insulin sensitizer agent like the thiazolidinedione compound troglitazone is considered a very promising drug. Troglitazone exerts an antihyperglycemic activity in a dose-dependent manner between 200 and 600 mg/day in type 2 diabetic patients treated with diet alone, sulfonylureas, or insulin. Additive antihyperglycemic effect may also be obtained by combining troglitazone and metformin. The antihyperglycemic effect of troglitazone as monotherapy is rather modest (reduction of HbA1c by 0.5-1.0%), but it appears to be somewhat greater when it is combined with other antidiabetic drugs. No double-blind studies have directly compared the activity of troglitazone with that of sulfonylureas or metformin. Troglitazone has been shown to exert additional beneficial effects on serum lipid profile and arterial blood pressure. It may be considered as a valuable alternative in insulin-resistant (obese and hyperinsulinemic) diabetic patients who appear to be the best responders to the drug. However, the efficacy of troglitazone is challenged by its safety profile, and the risk of hepatotoxicity still remains a major concern in clinical practice. [less ▲]

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See detailLe sémioticien
Durand, Pascal ULg

in Art&Fact (1999), (18), 81-82

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See detailImpairment of neocortical metabolism predicts progression in Alzheimer's disease
Herholz, K.; Nordberg, A.; Salmon, Eric ULg et al

in Dementia & Geriatric Cognitive Disorders (1999), 10(6), 494-504

Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset ... [more ▼]

Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible vs probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment. [less ▲]

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See detailAt the center, what?’ Giacomo Joyce, Roland Barthes and the Novelistic Fragment
Delville, Michel ULg

in James Joyce Quarterly (1999), 36(4), 765-780

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See detailHypnosis with conscious sedation instead of general anaesthesia? Applications in cervical endocrine surgery.
Meurisse, Michel ULg; Defechereux, Thierry ULg; Hamoir, Etienne ULg et al

in Acta Chirurgica Belgica (1999), 99(4), 151-8

Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnosedation (HYP) and compared to the operative data and postoperative ... [more ▼]

Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnosedation (HYP) and compared to the operative data and postoperative courses of a closely-matched population (n = 121) of patients operated on under general anaesthesia (GA). Conversion from hypnosis to GA was needed in two cases (1%). All surgeons reported better operating conditions for cervicotomy using HYP. All patients having HYP reported a very pleasant experience and had significantly less postoperative pain while analgesic use was significantly reduced in this group. Hospital stay was also significantly shorter, providing a substantial reduction of the medical care costs. The postoperative convalescence was significantly improved after HYP and full return to social or professional activity was significantly shortened. We conclude that HYP is a very efficient technique providing physiological, psychological and economic benefits to the patient. [less ▲]

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See detailHypo- et hypertension intracrâniennes bénignes
DELVAUX, Valérie ULg; DIOH, Alioune ULg; Schoenen, Jean ULg

in Ahead in neurology (1999), 3(1), 10-15

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See detailClinical use of a bioartificial liver to treat acetaminophen-induced fulminant hepatic failure
Detry, Olivier ULg; Arkadopoulos, N.; Kahaku, E. et al

in American Surgeon (1999), 65

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See detailProphylactic Use of Alfacalcidol in Corticosteroid-Induced Osteoporosis
Reginster, Jean-Yves ULg; Kuntz, D.; Verdickt, W. et al

in Osteoporosis International (1999), 9(1), 75-81

One hundred and forty-five patients suffering from diseases requiring long-term treatment with high doses of corticosteroids (30 mg/day or greater of prednisolone) were recruited to the study. Patients ... [more ▼]

One hundred and forty-five patients suffering from diseases requiring long-term treatment with high doses of corticosteroids (30 mg/day or greater of prednisolone) were recruited to the study. Patients had to be steroid naive on entry to the study (not more than 15 days of treatment with a corticosteroid within the previous 24 months). Patients were randomized to receive either 1 microgram/day alfacalcidol or placebo capsules for 12 months. Bone mineral density (BMD) of the lumbar spine was assessed by dual-photon absorptiometry on entry and after 3, 6 and 12 months' treatment. Safety was monitored by the recording of all adverse events reported by patients and the regular screening of blood samples for hematology and serum biochemistry. Of the 145 patients, 74 were randomized to alfacalcidol and 71 to placebo. The treatment groups were well matched at baseline with no significant differences in demographic, clinical or biochemical parameters. The mean equivalent dose of prednisolone at baseline was 46.6 mg/day and 46.3 mg/day for the alfacalcidol and placebo group respectively. From the 145 patients randomized to treatment, 71 (38 who received alfacalcidol and 33 who received placebo) provided BMD data both at baseline and at 3, 6 and 12 months. The percentage change in BMD after 6 months' treatment was -2.11% in the alfacalcidol group and -4.00% in the placebo group (p = 0.39). After 12 months the percentage change in BMD was +0.39% (CI: -4.28 to 4.81) in the alfacalcidol group and -5.67% (CI: -8.13 to -3.21) in the placebo group, this difference (6.06%, CI: 0.88 to 11.24) being statistically significant (p = 0.02). An intention to treat analysis also showed a significant difference between the two treatment groups in alfacalcidol's favor (3.81%, p = 0.01; CI: 0.92 to 6.70). There was no significant difference between the two treatment groups in the corticosteroid dose at any time point during the study. Serum calcium was measured throughout and there were no significant differences between the two treatment groups at any visit. This study suggests that alfacalcidol can prevent corticosteroid-induced bone loss from the lumbar spine. Long-term use of alfacalcidol was not associated with any significant adverse effects in this diverse group of patients. [less ▲]

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See detailGezelle, mens en onmens
Spinoy, Erik ULg

in Gezelliana. Kroniek van de Gezellestudie (1999)

This article reflects on how the work of the reactionary 19th-century Flemish poet Guido Gezelle can be 'saved' through innovative rereadings.

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See detailLa gestion forestière durable en Région wallonne : L'apport de l'inventaire permanent - Partie 2 : Intégration des indicateurs à l'inventaire
Lecomte, Hugues; Koestel, G.; Rondeux, Jacques ULg

in Silva Belgica (1999), 106(2), 7-14

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau ... [more ▼]

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau régional, un inventaire forestier permanent peut, outre les variables et paramètres qu'il traite habituellement, prendre en charge ces indicateurs. Moyennant quelques ajustements méthodologiques, il s'est avéré dans le cas de la Région wallonne, que l'Inventaire des Ressources ligneuses pouvait, grâce aux techniques d'échantillonnage qu'il met en oeuvre, constituer un outil pertinent pour dresser un état des lieux du développement durable en milieu forestier. En outre, du fait de son caractère permanent, il permet d'assurer le suivi de l'évolution des critères et indicateurs au cours du temps. Nous rappellerons très brièvement les bases méthodologiques de l'inventaire forestier régional (paragraphe 2) et les résultats de l'étude qui était destinée à lui faire prendre en compte des indicateurs de gestion durable (paragraphe 3). Nous nous attacherons à montrer comment ces indicateurs sont concrètement, selon les cas, observés, mesurés, calculés et traités (paragraphe 4), puis nous tirerons les quelques conclusions qui paraissent s'imposer (paragraphe 5). [less ▲]

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See detailAccumulation of glycosidically bound compounds in Fragaria * ananassa cv. Elsanta fruits at various developmental stages.
Groyne, Joëlle; Lognay, Georges ULg; Marlier, Michel

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(1), 5-9

Isolation of glycosidically bound compounds of Fragaria ´ ananassa cv. Elsanta was performed by Amberlite XAD-2 adsorption followed by methanol elution. After glycosidic extract hydrolysis with a ... [more ▼]

Isolation of glycosidically bound compounds of Fragaria ´ ananassa cv. Elsanta was performed by Amberlite XAD-2 adsorption followed by methanol elution. After glycosidic extract hydrolysis with a commercial b-glucosidase and liquidliquid extraction with diethyl ether, on-line coupled capillary gas chromatographic - mass spectrometric (HRGC-MS) identification of the liberated aglycons was achieved. Five developmental stages of strawberry fruit were investigated during ripening. The occurrence and accumulation of glycosides were pointed out and several aglycons were identified in relation with the investigated developmental stages, with a maximum for the overripe fruit. [less ▲]

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See detailContribution de l'hypertension arterielle au risque vasculaire du diabetique.
Marre, M.; Bouhanick, B.; Hadjadj, S. et al

in Diabètes & Métabolism (1999), 25 Suppl 3

Hypertension is a major cardiovascular risk factor in diabetic subjects. Recent trials have suggested that blood pressure objectives should be < or = 140/80 mmHg. However, there is currently no evidence ... [more ▼]

Hypertension is a major cardiovascular risk factor in diabetic subjects. Recent trials have suggested that blood pressure objectives should be < or = 140/80 mmHg. However, there is currently no evidence supporting any particular preferential drug strategy for this treatment objective. [less ▲]

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See detailL’importance de l’emploi dans le secteur non marchand
Mertens de Wilmars, Sybille ULg; Marée, Michel ULg

in Non Marchand : Management, Droit et Finance (1999), (4), 11-27

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See detailMise au point d'un test d'évaluation gestuelle du patient lombalgique
Vanderthommen, Marc ULg; DEFAWEUX, Michel ULg; TOMASELLA, Marco ULg et al

in Revue de la Société Belge des Ecoles du Dos (1999)

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See detailEvaluer et rééduquer les difficultés morpho-syntaxiques chez le jeune enfant : Du geste au langage
Comblain, Annick ULg

in Bulletin d'Audiophonologie (1999), 15(2), 223-236

L’acquisition du langage est, pour la majorité des enfants, rapide et harmonieuse. Entre l’apparition des premiers mots conventionnels et la maîtrise des structures syntaxiques de la lange maternelle, une ... [more ▼]

L’acquisition du langage est, pour la majorité des enfants, rapide et harmonieuse. Entre l’apparition des premiers mots conventionnels et la maîtrise des structures syntaxiques de la lange maternelle, une petite dizaine d’années s’écoulent. Pour 7 à 8 % des enfants, le langage va se développer plus lentement et plus laborieusement et pour 1%, le retard sera sévère et persistant en dehors de toute prise en charge logopédique spécifique. Chez ces enfants en difficultés d’apprentissage du langage, les aspects morphosyntaxiques de la langue restent une difficulté majeure et une pierre d’achoppement non négligeable dans le processus de rééducation. Il est donc crucial dans une démarche d’évaluation du langage d’évaluer cette composante langagière de manière complète et précise de manière à, d’une part poser un diagnostic fiable et quantifier l’ampleur du retard et des troubles de développement, et, d’autre part, à fixer avec le plus d’exactitude et de minutie possible les objectifs d’une rééducation. [less ▲]

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See detailInfluence de facteurs abiotiques ou biotiques sur l'evaluation de la sensibilite d'Aphidius rhopalosiphi De Stefani-Perez a la phosalone.
Guelton, O.; Mahaut, T.; Deleu, R. et al

in Parasitica (1999), 54(2-3),

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See detailIntracellular visualization of BrdU-labeled plasmid DNA/cationic liposome complexes.
El Ouahabi, A.; Thiry, Marc ULg; Schiffmann, S. et al

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1999), 47(9), 1159-66

Difficulties in specific detection of transfected DNA in cells represent an important limitation in the study of the gene transfer process. We studied the cellular entry and fate of a plasmid DNA ... [more ▼]

Difficulties in specific detection of transfected DNA in cells represent an important limitation in the study of the gene transfer process. We studied the cellular entry and fate of a plasmid DNA complexed with a cationic lipid, Vectamidine (3-tetradecylamino-N-tert-butyl-N'-tetradecylpropionamidine) in BHK21 cells. To facilitate its detection inside the cells, bromodeoxyuridine (BrdU) was incorporated into plasmid DNA under conditions that minimize plasmid alteration. BrdU was localized in cells incubated with Vectamidine/BrdU-labeled plasmid DNA complexes by immunogold labeling and electron microscopy (EM). Labeling was predominantly associated with aggregated liposome structures at the surface of and inside the cells. EM observations of cells transfected with Vectamidine/DNA complexes showed that the liposome/DNA aggregates accumulate in large vesicles in the cell cytosol. On the other hand, using rhodamine-labeled Vectamidine and revealing BrdU with FITC-conjugated antibodies permitted simultaneous detection in the cells of both components of the complexes with confocal laser scanning microscopy. The DNA and lipids co-localized at the surface of and inside the cells, indicating that the complex is internalized as a whole. Our results show that the BrdU-labeled plasmid DNA detection system can be a useful tool to visualize exogenous DNA entry into cells by a combination of electron and confocal microscopy. [less ▲]

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See detailIndices d'aptitude des procédés de production
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1999), (5), 26

This note describes the main process capability indices and presents some inferential porperties. A numerical example is analysed by Minitab and SAS softwares.

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See detailAnalysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.
Wang, Xingjun ULg; Tromp, G.; Cole, C. W. et al

in Matrix Biology (1999), 18(2), 121-4

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of ... [more ▼]

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of tissue remodeling are therefore candidate genes. We analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms (AAA), one individual with AAA and intracranial aneurysms (IA), four individuals with IA and two clinically unaffected individuals. We identified two nucleotide variants in both the TIMP1 and the TIMP2 coding sequences. All differences occurred in the third base positions of codons and were neutral polymorphisms. A significant difference was observed in the frequency of TIMP2 nt 573 polymorphism between 168 alleles from AAA patients and 102 control alleles. [less ▲]

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See detailComparison of intracellular and extracellular particles of the vaccinia virus
Vanderplasschen, Alain ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154

The construction of recombinant vaccinia viruses (VV) is definitely a promising approach to develop vaccines for pets. To produce safer VV recombinant vaccines, it is necessary to understand the ... [more ▼]

The construction of recombinant vaccinia viruses (VV) is definitely a promising approach to develop vaccines for pets. To produce safer VV recombinant vaccines, it is necessary to understand the pathogenesis of VV infection. The goal of this study was to compare the biological properties of the extracellular and intracellular infectious particles of VV. Four biological properties were investigated: (i) the binding into cellular receptor(s); (ii) the mechanism of entry; (iii) the resistance to neutralisation by antibodies; (iv) the resistance to complement lysis. The results obtained in this study emphasize the differences existing between the two infectious forms of VV and demonstrate the adaptation of the extracellular particle to its role of virus dissemination in vivo. The results of this study implicate that VV strains used as expression vector in vaccinology should be deleted for genes required for EEV morphogenesis. [less ▲]

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See detailEfectos antitumorales de los agonistas dopaminergicos y de los anàlogos de la somatostatina
Valdes Socin, Hernan Gonzalo ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in Revista Argentina de Endocrinologia y Metabolismo (1999), 36(4), 234-246

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See detailSistema familiare e disturbi del comportamento alimentare: dati preliminari di una ricerca.
Onnis, Luigi; Di Gennaro, A.; Antenucci, M. et al

in Psichiatria (1999)

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See detailCurrent perspectives on developmental dysphasias
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Journal of Neurolinguistics (1999), 12(3-4), 181-212

This paper documents the major difficulties observed in the oral language development of individuals with mental retardation of genetic origin. The extent of inter- and within-syndrome variability is ... [more ▼]

This paper documents the major difficulties observed in the oral language development of individuals with mental retardation of genetic origin. The extent of inter- and within-syndrome variability is evaluated. More specifically, a comparative analysis of typical language phenotypes in several genetic syndromes is attempted and the possible brain underpinnings of the observed differences are envisaged. Recent cases of favorable language development in individuals with mental retardation are summarized and explanatory variables are discussed. [less ▲]

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