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See detailRapid and Selective Isolation of Follicular Dendritic Cells by Low Speed Centrifugations on Discontinuous Bsa Gradients
Marcoty, C.; Heinen, Ernst ULg; Antoine, Nadine ULg et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailMonoamine Oxidase Inhibitors and Anesthesia: An Updated Literature Review
Blom-Peters, L.; Lamy, Maurice ULg

in Acta Anaesthesiologica Belgica (1993), 44(2), 57-60

Safe anesthesia for patients taking MAOIs has been possible since the 1980s using judicious choice of agents. The introduction of a new class of MAOIs (RIMA) has increased the margin of safety for these ... [more ▼]

Safe anesthesia for patients taking MAOIs has been possible since the 1980s using judicious choice of agents. The introduction of a new class of MAOIs (RIMA) has increased the margin of safety for these anesthetics. These drugs allow selective and rapidly reversible inhibition of type A-MAO. The pharmacologic effects of this new class of drug as well as their potential interactions with agents used in anesthesia are reviewed. [less ▲]

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See detailEffects of Proglumide and Enprostil on Omeprazole-Induced Fundic Endocrine Cell Hyperplasia in Rats
Delwaide, Jean ULg; Latour, Pascale ULg; Gast, Pierrette ULg et al

in Gastroentérologie Clinique et Biologique (1993), 17(11), 792-6

Long-term treatment with omeprazole induces hyperplasia of enterochromaffin-like cells, closely related to hypergastrinemia. We studied whether proglumide, an antagonist of gastrin/CCK receptor, and ... [more ▼]

Long-term treatment with omeprazole induces hyperplasia of enterochromaffin-like cells, closely related to hypergastrinemia. We studied whether proglumide, an antagonist of gastrin/CCK receptor, and enprostil, a synthetic prostaglandin E2 derivative, might inhibit this hyperplasia. Six groups of 8 rats were treated for 10 weeks: a) untreated controls; b) omeprazole 10 mumol/kg; c) proglumide 500 mg/kg; d) enprostil 30 micrograms/kg; e) association of omeprazole and proglumide; f) association of omeprazole and enprostil. Serum gastrin levels were measured at different times during treatment. After sacrifice, fundic argyrophil cells were assessed by Grimelius' staining. Serum gastrin levels and argyrophil cell density were not modified in proglumide- and enprostil-treated groups, as compared with controls. Omeprazole increased significantly these two parameters. When given with omeprazole, proglumide decreased significantly serum gastrin levels and argyrophil cell density, as compared to omeprazole alone, while enprostil did not modify significantly these two parameters. These results indicate that proglumide, but not enprostil, can counteract the omeprazole-induced argyrophil cell hyperplasia in rats. [less ▲]

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See detailSpelling en spellingverandering : een slingerbeweging in de tijd
Vromans, Joseph ULg

in Nederlands van Nu (1993), 41

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See detailLe traitement des adénomes à prolactine : utilisation d'un nouvel agoniste dopaminergique à longue durée d'action, la cabergoline, chez 56 patients
Beckers, Albert ULg; Abs, R.; Demez, Pierre ULg et al

in Médecine et Hygiène (1993), 51(1990), 1978-1980

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de ... [more ▼]

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de macroadénome dans 21 cas ont été traités durant des périodes variant entre 1 et 17 mois à des doses de cabergoline variant entre 0,25 mg et 2 mg par semaine, prises à raison de 1 à 4 fois par semaine. Cette nouvelle substance nous est apparue extrêmement efficace et très bien tolérée [less ▲]

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See detailPalaeolithic and Mesolithic Research in Belgium, 1993: le Trou Magrite, Huccorgne & l'Abri du Pape
Straus, Lawrence; Otte, Marcel ULg; Cordy, Jean-Marie ULg et al

in Old World Archaeology Newsletter (1993), XVII(1), 17-24

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See detailTYPE OF WEAR FOR THE PAIR TI6A14V/PCTFE IN AMBIENT AIR AND IN LIQUID-NITROGEN
Bozet, Jean-Luc ULg

in Wear (1993), 162(Part B), 1025-1028

In the development of large, high pressure valves for cryotechnic rocket engines, the Tribology Department of the University of Liege had the opportunity to evaluate the pair Ti6Al4V ... [more ▼]

In the development of large, high pressure valves for cryotechnic rocket engines, the Tribology Department of the University of Liege had the opportunity to evaluate the pair Ti6Al4V/polychlorotrifluoroethylene (PCTFE) on a pin-on-disk tribometer in ambient air and liquid nitrogen with the contact pressure and sliding speed ranging, respectively, from 3 to 9 MPa and 0.03 to 0.05 m s-1. Because of the affinity of titanium for halogen elements, such as chlorine and fluorine, which are both present in PCTFE, we noticed the formation of an abrasive compound made of chlorine, fluorine, titanium and aluminium. These elements were detected by electron microscopy. In both environments the heat produced during sliding is responsible for the decomposition of the PCTFE. The surface of the polymer is softened by the heat and embedded abrasive particles then scratch the sliding track of the Ti6Al4V disk. This abrasiveness is confirmed with a three-dimensional stylus profilometer used on the Ti6Al4V disks. The low temperature and neutrality of liquid nitrogen hardly inhibit the decomposition of the polymer. This is related to the poor thermal conductivity of both titanium and PCTFE: the heat produced at the contact is fully available for the chemical reaction between the chlorine, fluorine and titanium, all the more so since this reaction requires little energy to take place. A better understanding of the wear behaviour of the pair PCTFE/Ti6Al4V in both air and liquid nitrogen should lead to the development of a surface treatment which prevents the formation of abrasive particles. We could then use titanium alloys as bulk materials for sliding parts in cryogenic valves and, because of the low specific mass of titanium, could benefit from the subsequent weight reduction. [less ▲]

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See detailVidéographie à caractère historique : essai d'inventaire et Audiovisuel, histoire et enseignement : repères bibliographiques
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1993), 44e année(n°4),

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See detailEnhancement of metastatic potential of murine and human melanoma cells by laminin receptor peptide G: attachment of cancer cells to subendothelial matrix as a pathway for hematogenous metastasis.
Taraboletti, G.; Belotti, D.; Giavazzi, R. et al

in Journal of the National Cancer Institute (1993), 85(3), 235-40

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly ... [more ▼]

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly plays a crucial role in this event, the exact interactive pathways among cancer cells, laminin, and the vessel wall have not been elucidated. In a previous study, we identified synthetic peptide G, which contains the laminin-binding domain of the 67-kd laminin receptor and which inhibits tumor cell adhesion to endothelial cells. PURPOSE: To assess the role of the interaction between laminin and the 67-kd laminin receptor in hematogenous metastasis formation, we studied the effect of peptide G on melanoma cell behavior in vivo and in vitro. METHODS: The effect of peptide G and control peptides was studied in vivo on lung retention and colonizing potential of murine (B16BL6) and human (A2058) melanoma cells injected intravenously in C57BL/6 and nude mice, respectively. In addition, their effect on cell adhesion and chemotaxis to laminin and on binding of iodine 125-labeled laminin to cells was studied in vitro. RESULTS: In vivo, pretreatment of cells with peptide G resulted in a two- to 10-fold significant increase in the number of experimental lung metastases. A significant relative increase in lung retention of peptide G-treated tumor cells was observed 48 hours after injection, although after 4 hours a partial reduction was observed. In vitro, peptide G significantly increased laminin binding and cancer cell adhesion to laminin and subendothelial matrix, whereas chemotaxis to laminin was significantly inhibited. CONCLUSIONS: Peptide G differentially affected the biological response of cancer cells to laminin. In vitro, it increased laminin binding and cell adhesion to laminin and subendothelial matrix, whereas it inhibited cell chemotaxis to laminin. In vivo, the overall effect of peptide G was an augmentation of lung metastasis. IMPLICATIONS: Our findings suggest that direct adhesion of tumor cells to the subendothelial matrix is a main pathway for hematogenous metastases and that tumor cell-matrix interaction may be more relevant than tumor cell-endothelial cell attachment in this process. [less ▲]

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See detailImmunodetection of RNA on ultra-thin sections incubated with polyadenylate nucleotidyl transferase.
Thiry, Marc ULg

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1993), 41(5), 657-65

A new method is described for locating RNA on ultra-thin sections. Sections of aldehyde-fixed, plastic-embedded cells were incubated in a medium containing polyadenylate nucleotidyl transferase (PnT) and ... [more ▼]

A new method is described for locating RNA on ultra-thin sections. Sections of aldehyde-fixed, plastic-embedded cells were incubated in a medium containing polyadenylate nucleotidyl transferase (PnT) and biotinylated ATP. The labeled nucleotides bound to RNA at the surface of the ultra-thin sections were than visualized by an indirect immunogold labeling technique. The resulting labeling pattern was dependent on the presence of divalent cations in the PnT medium. The method revealed with great precision the specific RNA-containing structures within Ehrlich tumor cells. The method is applicable to Epon sections. However, the labeling intensity varies according to the fixation used. Best results were obtained on acetylated cell sections. The method can be combined with EDTA regressive staining. The in situ PnT method provides a very useful tool for pinpointing the precise location of RNA within biological material at the ultrastructural level. [less ▲]

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See detailSell-Off en de welvaart van aandeelhouders
Corhay, Albert ULg; Tourani-Rad, Alireza

in Maandblad voor Accountancy en Bedrijfseconomie [=MAB] (1993), 67(10), 471-477

In het kader van de herstructurering van het Nederlandse bedrijfsleven vindt de laatste jaren een groot aantal Sell-Offs plaats. Theoretici betogen dat een Sell-Off een aantal voordelen voor het ... [more ▼]

In het kader van de herstructurering van het Nederlandse bedrijfsleven vindt de laatste jaren een groot aantal Sell-Offs plaats. Theoretici betogen dat een Sell-Off een aantal voordelen voor het afstotende moederbedrijf oplevert. Blijkens deze studie ondersteunt het empirische onderzoek de theorie. In Nederland lijken significante buitengewone positieve koerseffecten op de dag van aankondiging voor de aandeelhouders van de verkopende bedrijven met dit soort transacties gepaard te gaan. Tevens is vastgesteld dat de aard van de aankondiging en de bekendmaking van het motief voor de Sell-Off positieve significante invloed heeft op de grootte van het buitengewoon rendement. Ten slotte is geconcludeerd dat alleen in het geval van buiten Nederland gevestigde dochters sprake is van een positief significant rendement [less ▲]

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See detailP. Colon. Inv. 4781 verso: vente d'une esclave
Straus, Jean ULg

in Zeitschrift für Papyrologie und Epigraphik (1993), 98

Edition du contrat de vente d'une esclave. Papyrus grec d'Egypte. Ptolémaïs Euergétis, 3 décmebre 65

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See detailProduction of hemicellulase by Penicillium canescens 10-10C. Arch. Int. Phys. Bioch., 101, B1-B00.
Fonder, C.; Rikir, R.; Kvesitadze, G. et al

in Archives Internationales de Physiologie et de Biochimie (1993), 101(B1-B100),

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See detailTemperature, air humidity and air pollution levels in breeding pig houses
Nicks, Baudouin ULg; Canart, B.; Vandenheede, Marc ULg

in Pigs News and Information (1993), 14(2), 77-78

A study was undertaken to provide practical information concerning the frequency of temp. and RH measurements required to obtain a good estimate of their averages and of their daily variations, and to ... [more ▼]

A study was undertaken to provide practical information concerning the frequency of temp. and RH measurements required to obtain a good estimate of their averages and of their daily variations, and to determine the relationships between ammonia, carbon dioxide and bacterial concn in a pig house. Measurements were made in 9 artificially ventilated farrowing or weaner houses with slatted floors. Temp. and RH were measured every 20 min for 7 d. Sensors were placed inside buildings in the middle of the houses, 0.8 m above floor level, and outside the buildings. Data were recorded using a datalogger. Ammonia and carbon dioxide concn were measured using 8 h Gastec diffusion tubes. Three readings were taken in the same location at 2-day intervals. The airborne bacterial concn was measured with a 6-stage Andersen sampler. Bacteria colony forming particles (BCFP) were collected by impacting onto agar-filled petri dishes which are placed in an incubator for 24 h prior to counting the colonies formed. Results are discussed, indicating no significant correlation between the 3 measures of pollution (NH3 and CO2 concn, BCFP levels) despite careful microclimate control. [less ▲]

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See detailSynthetic model peptides for apolipoproteins. I. Design and properties of synthetic model peptides for the amphipathic helices of the plasma apolipoproteins.
Brasseur, Robert ULg; Vanloo, B.; Deleys, R. et al

in Biochimica et Biophysica Acta (1993), 1170(1), 1-7

Amphipathic helical peptides are the lipid-binding motives of the plasma apolipoproteins, and synthetic peptide analogs have been used to unravel the mechanism of lipid association within this class of ... [more ▼]

Amphipathic helical peptides are the lipid-binding motives of the plasma apolipoproteins, and synthetic peptide analogs have been used to unravel the mechanism of lipid association within this class of proteins. Hydrophobic interactions between the apolar amino acid residues belonging to the hydrophobic face of the amphipathic helices and the lipids are the major driving forces in the peptide-lipid association to form discoidal complexes. Ionic interactions and salt bridge formation between contiguous peptide chains in the complex can, however, contribute to the overall stability of the lipid-protein particle. This was studied by designing peptide analogs to the helical repeats of the apolipoproteins with variable degrees of salt bridge formation between adjacent peptide chains. The most stable conformation for pairs of synthetic peptides was calculated by energy minimisation together with the energy of interaction between peptides. The sequence of the peptides was derived from that of the 18A peptide synthesized by Segrest et al., and the theoretical calculations confirmed that ionic interactions between residues close to each other, along the edge of two adjacent anti-parallel peptides, can significantly contribute towards the stability of a peptide-phospholipid complex. [less ▲]

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See detailConditional heteroscedasticity in pacific-basin stock market returns
Corhay, Albert ULg; Tourani-Rad, Alireza

in Research in International Business and Finance (1993), 10

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return ... [more ▼]

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return-generating models which empirically fit the data are processes with conditional heteroscedastic innovations. Particularly, the generalized autoregressive conditional heteroscedastic GARCH(1,1) process turns out to be the best in most cases. [less ▲]

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See detailLa saisie électronique des données en forêt : réalités et perspectives
Rondeux, Jacques ULg

in Revue Forestière Française (1993), 45(n° sp), 20-26

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See detailMourir à son postmoderne
Demoulin, Laurent ULg

in Ecritures (1993), 5

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à ... [more ▼]

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à distinguer du postmodernisme (si celui-ci existe). [less ▲]

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See detailTextual Space in Un chien Andalou
Drummond, Philippe; Van Cauwenberge, Geneviève ULg

in La revue belge du cinéma (1993), 33-35

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See detailEnhancement of bovine leukemia virus-induced syncytia formation by di- and tripeptides.
Voneche, V.; Callebaut, I.; Lambrecht, B. et al

in Virology (1993), 192(1),

Short hydrophobic peptides were previously shown to inhibit infectivity of para- and orthomyxoviruses. We tested the ability of a series of di- and tripeptides to interfere with cell fusion induced by ... [more ▼]

Short hydrophobic peptides were previously shown to inhibit infectivity of para- and orthomyxoviruses. We tested the ability of a series of di- and tripeptides to interfere with cell fusion induced by bovine leukemia virus (BLV). Peptides containing a hydrophobic contribution and/or a positive net charge strongly enhanced syncytia formation induced by BLV on CC81 indicator cells. The size of the multinucleated cells was strongly increased (up to 10-fold) in the presence of the enhancer peptides whereas no effect was observed on the indicator cells in the absence of BLV. The peptides thus amplified the fusion process initiated by BLV envelope glycoproteins. The effect was dose-dependent at concentrations ranging from 20 to 640 microM and did not result from an increased expression of BLV proteins. The peptides did not compete with anti-gp51 monoclonal antibodies for the recognition of eight well-defined epitopes of gp51. We consequently hypothesize that the enhancer peptides interact with the membrane of BLV-producing cells and/or indicator cells and propose a model based on molecular modeling. [less ▲]

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See detailModeling of the chemical processes in a longwall face underground gasifier at great depth
COEME, Antoinette; Pirard, Jean-Paul ULg; MOSTADE, Marc

in In Situ (1993), 17(1), 83-104

In order to simulate the cavity growth of an underground gasifier in thin seams, at great depth, Wilks1,2 has developed an original model based on the distribution of fluid flows around an injection well ... [more ▼]

In order to simulate the cavity growth of an underground gasifier in thin seams, at great depth, Wilks1,2 has developed an original model based on the distribution of fluid flows around an injection well. In this paper, we aim to introduce within this model a description of chemical processes on the wall and within the fluid phase, in order to determine the temperature and concentration profiles along the coal wall. These profiles are dependent only on two factors: the transfer coefficients and the energy balance of the gas generator. A study of the sensitivity of the operating variables has been carried out. [less ▲]

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See detailThe 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis
Clapp, Carmen; Martial, Joseph ULg; Guzman, Raphaël C et al

in Endocrinology (1993), 133(3), 1292-9

The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable ... [more ▼]

The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable therapeutic potential in the treatment of cancer. We previously reported that the 16-kilodalton N-terminal fragment of rat PRL (16K rPRL) was a potent inhibitor of capillary endothelial cell proliferation via a novel receptor. We now report that the nanomolar concentrations of recombinant human 16K PRL inhibit basal and basic fibroblast growth factor- or vascular endothelial growth factor-stimulated growth of bovine brain capillary endothelial cells. 16K human (h) PRL also inhibits stimulation of human umbilical vein endothelial cell proliferation by basic fibroblast growth factor. The organization of endothelial cells into capillary-like structures in type I collagen gels is also prevented by 16K hPRL. Furthermore, in an in vivo assay, the chick embryo chorioallantoic membrane assay, 16K hPRL as well as 16K rPRL were potent inhibitors of capillary formation. 16K hPRL, like 16K rPRL, maintains its biological activity as a partial PRL agonist at PRL receptors on mammary gland epithelial cells. These data demonstrate for the first time that the biological activity of 16K rPRL is not unique and that similar fragments of hPRL are active. The antiangiogenic activity of these molecules is conserved across avian and mammalian species. That 16K hPRL is a potent antiangiogenic factor in in vitro and an in vivo assay raises the exciting potential of this peptide being capable of inhibiting tumor growth. [less ▲]

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See detailMathematical Programming Methods for Constrained Optimization: Dual Methods
Fleury, Claude ULg

in Progress in Astronautics and Aeronautics (1993), 150

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See detailMallarmé, “termite silencieux”. L’auto-liquidation de la poésie
Durand, Pascal ULg

in Romantisme (1993), 81

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See detailFollicular Dendritic Cells Do Not Produce Tnf-Alpha nor its Receptor
Mancini, I.; Bosseloir, A.; Hooghe-Peters, E. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailTHERMAL-CONDUCTIVITY OF TWINNED YBA2CU3O7-X AND TWEEDED YBA2(CU0.95FE0.05)3O7-X IN A MAGNETIC-FIELD - EVIDENCE FOR INTRINSIC PROXIMITY EFFECT
Bougrine, Hassan ULg; SERGEENKOV, S.; Ausloos, Marcel ULg et al

in Solid State Communications (1993), 86(8), 513-516

The behavior of the thermal conductivity kappa of twinned YBa2Cu3O7-x and tweeded YBa2(Cu0.95Fe0.05)3O7-x polycrystals in a magnetic field up to 5 T is presented. Data as a function of field are shown to ... [more ▼]

The behavior of the thermal conductivity kappa of twinned YBa2Cu3O7-x and tweeded YBa2(Cu0.95Fe0.05)3O7-x polycrystals in a magnetic field up to 5 T is presented. Data as a function of field are shown to depart from the usual linear behavior of thermal magnetoresistivity (TMR) kappa-1 (B) for conventional superconductors. A set of stretched exponential laws, of the form kappa-1 (B) - kappa-1 (0) = CB exp(-pB(q)) has been found to describe our data with q decreasing with temperature from 1 to 1/2 and from 1/2 to 1/4 for pure and iron-doped samples, respectively, in contrast to the unique interpolation formula (q = 1/4) for TMR proposed recently by Richardson et al. [1] to fit their data on twinned and untwinned single crystals. Such a complex behavior of TMR in the high field region is supposed to originate from extended defect mediated intrinsic proximity effect in both samples. The proposed interpretation is based on incorporating two types of phonon scatterers, free (unpinned) and pinned (by the defect cores) vortices, into a conventional picture of phonon-vortex scattering mechanism. [less ▲]

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See detailInventaire préliminaire sur le patrimoine campanaire de l'église Saint-Servais à Liège
Marganne, Marie-Hélène ULg; Mélard, Marc

in Bulletin de la Société Royale Le Vieux-Liège (1993), 261

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See detailThe Transcriptional Regulation of the Growth Hormone Gene Is Conserved in Vertebrate Evolution
Argenton, F.; Vianello, S.; Bernardini, S. et al

in Biochemical and Biophysical Research Communications (1993), 192(3), 1360-1366

Growth hormone (GH) gene expression in mammals is regulated by the interaction of the transcription factor Pit-1 with two binding sites within the proximal promoter. Four sequences, homologous to the ... [more ▼]

Growth hormone (GH) gene expression in mammals is regulated by the interaction of the transcription factor Pit-1 with two binding sites within the proximal promoter. Four sequences, homologous to the mammalian Pit-1 motif occur in the rainbow trout (Oncorhynchus mykiss) GHII (rtGH) gene promoter, two of which partly overlap. The three regions containing these putative Pit-1 binding sequences were protected from deoxyribonuclease I digestion by nuclear extracts of GC cells, a rat pituitary tumor cell line producing Pit-1. In gel shift assays, nuclear proteins from GC cells and from trout pituitaries were found to interact specifically with one of these protected sites. Transfection experiments showed that the rtGH promoter is transcnptionally active in GC cells, the response being strongly enhanced in the presence of a cAMP analogue. The results demonstrate that rat Pit-1 binds to and activates the rtGH promoter, indicating that the basic mechanisms regulating GH gene transcription have been conserved between fish and mammals. [less ▲]

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See detailModelling the Arterial Wall by Finite Elements
Mosora, F.; Harmant, A.; Hallet, Claude ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1993), 101(3, May-Jun), 185-91

The mechanical behaviour of the arterial wall was determined theoretically utilizing some parameters of blood flow measured in vivo. Continuous experimental measurements of pressure and diameter were ... [more ▼]

The mechanical behaviour of the arterial wall was determined theoretically utilizing some parameters of blood flow measured in vivo. Continuous experimental measurements of pressure and diameter were recorded in anesthetized dogs on the thoracic ascending and midabdominal aorta. The pressure was measured by using a catheter, and the diameter firstly, at the same site, by a plethysmograph with mercury gauge and secondly, by a sonomicrometer with ferroelectric ceramic transducers. The unstressed radius and thickness were measured at the end of each experiment in situ. Considering that the viscous component is not important relatively to the nonlinear component of the elasticity and utilizing several equations for Young modulus calculation (thick and thin wall circular cylindrical tube formulas and Bergel's equation) the following values were obtained for this parameter: 0.6 MPa-2 MPa in midabdominal aorta and 2 MPa-6.5 MPa in thoracic ascending aorta. The behaviour of the aorta wall was modelled considering an elastic law and using the finite element program "Lagamine" working in large deformations. The discretized equilibrium equations are non-linear and a unique axi-symmetric, iso-parametric element of 1 cm in length with 8 knots was used for this bi-dimensional problem. The theoretical estimation of radius vessel, utilizing a constant 5 MPa Young modulus and also a variable one, are in good agreement with the experimental results, showing that this finite element model can be applied to study mechanical properties of the arteries in physiological and pathological conditions. [less ▲]

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See detailResistance a la secheresse et reponses a l'acide abscissique: analyse d'une approche synthetique.
El-Jaafari, S.; Paul, Roger ULg; Lepoivre, Philippe ULg et al

in Cahiers Agricultures (1993), 2(4),

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See detailLes méthodes d'analyse factorielle : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1993), 1

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements ... [more ▼]

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements useful when interpreting the results of an analysis and the methods are illustrated by completely worked out examples. [less ▲]

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See detailIdentification of 108k, 93k, and 42k Glycoproteins of Bovine Herpesvirus-1 by Monoclonal Antibodies
Baranowski, E.; Dubuisson, J.; Pastoret, Paul-Pierre ULg et al

in Archives of Virology (1993), 133(1-2), 97-111

Three glycoproteins of bovine herpesvirus-1 (BHV-1) other than glycoproteins gI, gIII, and gIV were identified by monoclonal antibody (MAb) analyses. Monoclonal antibodies were obtained by immunization of ... [more ▼]

Three glycoproteins of bovine herpesvirus-1 (BHV-1) other than glycoproteins gI, gIII, and gIV were identified by monoclonal antibody (MAb) analyses. Monoclonal antibodies were obtained by immunization of mice with either BHV-1 envelope or virus infected cells, from which the glycoproteins gI, gIII, and gIV were removed by immunoaffinity. In the latter immunization procedure mice were tolerized either against normal cellular antigens with or without glycoproteins gI, gIII, gIV, and nucleocapsid. From 154 anti-BHV-1 hybridomas isolated, 39 MAbs precipitated a 108K glycoprotein. Two other glycoproteins of respectively 42K and 93K were precipitated each by one MAb. These three glycoproteins were detected in infected cell lysate. Nine anti-108K glycoprotein MAbs neutralized BHV-1 infectivity and three non-neutralizing MAbs were able to reduce plaque development when virus was grown in the presence of these MAbs. It is therefore suggested that this glycoprotein is involved in viral entry into the cell and in cell-to-cell spread of the virus. [less ▲]

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See detailApport de la mesure ambulatoire de la pression artérielle dans une consultation d'hypertension artérielle
Saint-Remy, Annie ULg; Dubois, Bernard ULg; Krzesinski, Jean-Marie ULg et al

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (1993), 5(1), 6-13

La fréquence du syndrome de la blouse blanche, l'importance de la charge tensionnelle et de la variabilité de la pression artérielle au cours du nycthémère ont été analysées dans une population de 181 ... [more ▼]

La fréquence du syndrome de la blouse blanche, l'importance de la charge tensionnelle et de la variabilité de la pression artérielle au cours du nycthémère ont été analysées dans une population de 181 patients ayant bénéficié d'un enregistrement de la pression artérielle en ambulatoire pendant 24 heures. En dépit d'une bonne corrélation entre la mesure clinique de la pression artérielle et la pression moyenne de jour ou de 24 heures, on observe une discordance entre les niveaux de pression fournis par les deux méthodes (la pression clinique étant supérieure à la pression en ambulatoire et cela d'autant plus que la pression clinique est élevée). Lors de l'évaluation de l'efficacité du traitement antihypertenseur, l'analyse des tracés montre qu'un tiers des patients traités ont des pressions normalisées, alors que deux tiers d'entre eux conservent des pressions de jour et de 24 heures nettement supérieures aux critères définissant l'hypertension artérielle. Par ailleurs, cette étude souligne également la supériorité des valeurs de pression en ambulatoire (surtout la pression systolique) par rapport à la pression clinique comme prédicteur d'une hypertrophie ventriculaire gauche. Ces observations confirment l'intérêt de cette technique non invasive de mesure de la pression artérielle moyenne tant pour objectiver l'effet blouse blanche, et ainsi préciser le diagnostic d'une hypertension artérielle, que pour s'assurer du contrôle de la pression par les thérapeutiques antihypertensives. [less ▲]

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See detailInterface entre médecin de famille, référent social et psychiatrie: un hôpital de jour
Triffaux, Jean-Marc ULg; Halkin, Stéphane ULg; Bertrand, Jean ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1993)

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See detailA concise guide to the temporal maze
Richelle, Marc ULg

in Psychologica Belgica (1993), 33(2), 135-145

The paper provides a concise historical survey of the expanding field of time psychology, pointing to the important contributions, in its early stages as well as today, of European psychologists. An ... [more ▼]

The paper provides a concise historical survey of the expanding field of time psychology, pointing to the important contributions, in its early stages as well as today, of European psychologists. An evaluation of past and current research is proposed, and prospects for further development suggested, especially with regard to neglected areas and to issues related to applied situations. [less ▲]

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See detailDetection of ribosomal RNA during the cell cycle in Ehrlich tumour cells by electron microscope in situ hybridization.
Thiry, Marc ULg

in European Journal of Morphology (1993), 31(1-2), 13-6

The fine spatial distribution of rRNA within Ehrlich tumour cells has been investigated during the cell cycle by in situ hybridization with a biotinylated probe. In interphase cells, rRNA was essentially ... [more ▼]

The fine spatial distribution of rRNA within Ehrlich tumour cells has been investigated during the cell cycle by in situ hybridization with a biotinylated probe. In interphase cells, rRNA was essentially detected in the ribosome-rich cytoplasmic regions and in the three main nucleolar components. In mitotic cells, besides the presence, as expected, of rRNA in the ribosome-rich spaces, evident label was observed over material situated around and between the chromosomes during anaphase and telophase as well as over the reforming nucleoli during telophase. [less ▲]

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See detailEnzymatic hydrolysis of reconstituted dimyristoylphosphatidylcholine-apo A-I complexes.
Lins, Laurence ULg; Piron, S.; Conrath, K. et al

in Biochimica et Biophysica Acta (1993), 1151(2), 137-42

Apolipoproteins share a common structural feature, their interaction with phospholipids. It is believed that amphipathic helical sequences enable apolipoproteins to bind to lipid bilayer and to form ... [more ▼]

Apolipoproteins share a common structural feature, their interaction with phospholipids. It is believed that amphipathic helical sequences enable apolipoproteins to bind to lipid bilayer and to form discoidal particles of defined dimensions. While the knowledge of the apo A-I sequence and secondary structure has been used to make predictions about its mode of association with lipids, the available experimental data necessary to propose a precise model of these discoidal structures are still limited. An important step in our understanding of these structures would be to identify the apolipoprotein lipid-associated domains. Proteolysis of apo A-I-DMPC reconstituted HDL (rHDL) and free apo A-I is used here to identify lipid-protected domains of apo A-I. Free cleaved peptides were separated from rHDL associated peptides by density gradient centrifugation. The lipid-associated peptides were further analyzed by SDS-PAGE and transferred by Western blot to a ProBlott membrane for sequencing. Cleavage occurred at residue 43 with proteinase K, 46 with trypsin and residue 47 or 48 with pronase. A large domain from about residue 45 to the C-terminal remains highly protected against hydrolysis eventhough it contains several bonds susceptible to proteolytic cleavage. No protected fragments were detected by SDS-PAGE after enzymatic cleavage of free apo A-I in identical experimental conditions. [less ▲]

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See detailThyrotropin-releasing hormone and epidermal growth factor induce human prolactin expression via identical multiple cis elements
Berwaer, Monique; Peers, Bernard ULg; Nalda, Asuncion M et al

in Molecular & Cellular Endocrinology (1993), 92(1), 1-7

Pituitary GH3 cells were transfected with different deletion mutants of the human prolactin (hPRL) promoter fused to the CAT reporter gene. The proximal region (-250 to -42) was sufficient to confer ... [more ▼]

Pituitary GH3 cells were transfected with different deletion mutants of the human prolactin (hPRL) promoter fused to the CAT reporter gene. The proximal region (-250 to -42) was sufficient to confer stimulation by both thyrotropin-releasing hormone (TRH) and epidermal growth factor (EGF). Further deletion analyses demonstrated the importance of the three proximal Pit-1 binding sites in this response. However, Pit-1 binding oligonucleotides confer neither TRH nor EGF induction to a linked neutral promoter, suggesting that other elements might be involved. We have previously shown that sequence A (-115 to -85) is needed together with Pit-1 binding sites for full cyclic AMP response of hPRL-CAT. Mutation of this sequence strongly affects TRH and EGF induction. On the other hand, three copies of sequence A confer both TRH and EGF response to a linked neutral promoter. In conclusion, although TRH and EGF activate mostly different intracellular pathways, they mediate transcriptional induction of the hPRL promoter via identical cis elements. [less ▲]

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See detailPhysiologie de la cellule enterochromaffin-like (ECL) dans la régulation de la sécrétion gastrique acide
Delwaide, Jean ULg; Belaiche, Jacques ULg; Latour, Pascale ULg

in Médecine & Chirurgie Digestives (1993), 22

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir ... [more ▼]

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir quelle était la cellule fundique qui produisait de l'histamine dans les conditions physiologiques. Deux cellules seront envisagées, les mastocytes et les cellules ECL qui sont des cellules endocrines exclusivement localisées dans le fundus. Quelques arguments seront développés, dont ceux provenant de notre expérience, permettant de penser que la cellule ECL contient de l'histamine. L'article se terminera par un essai d'intégration de la cellule ECL dans le schéma de la sécrétion gastrique acide en montrant son rôle essentiel potentiel. [less ▲]

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See detailThermal conductivity measurements in soil using an instrument based on the cylindrical probe method
Nicolas, Jacques ULg; Andre, Philippe ULg; Rivez, Jean-François et al

in Review of Scientific Instruments (1993), 64(3), 774-780

The article discusses the underlying hypothesis, the limits, the range of application, and the practical operation of a versatile thermal conductivity analyzer based on a transient cylindrical probe ... [more ▼]

The article discusses the underlying hypothesis, the limits, the range of application, and the practical operation of a versatile thermal conductivity analyzer based on a transient cylindrical probe method. The best expected precision for the conductivity determination appears to be ~±10%. A compact analyzer, integrating all the apparatus' components in the same unit, has been specifically designed for environmental research in the field. Calibration received special attention regarding thermal conductivity values in the range 0.1–3 W/mK. The analyzer was tested on seven materials, in field conditions, and discrepancies from published conductivity values did not exceed 9%. Several checks were performed in the laboratory to study the influence of experimental conditions, such as the probe insertion technique. The cylindrical probe method appears well suited to powdered materials, but may also be applied to viscous liquids and solid matter. As an application, the cylindrical probe was used to characterize nine soils from the Belgian Lorraine. After soil analysis in the dry state, thermal conductivity of each sample was determined at different moisture contents. The transient cylindrical probe method proved to be quick and easy, whether in situ or on samples in the laboratory. It is a powerful tool which can map a country's soil thermal properties. [less ▲]

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See detailIntercultural Education in French-speaking Belgium : an overview of ideology, legislation and practice
Martiniello, Marco ULg; Manço, Altay

in European Journal of Intercultural Education (1993), 4(2), 19-28

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See detailEffects on performance and meat characteristics of a diet supplemented with fat during the finishing period of growing fattening bulls
Hollo, Véronique; Marche, Christian; Dufrasne, Isabelle ULg et al

in Animal Production (1993), 56

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See detailFructose utilization during exercise in men: rapid conversion of ingested fructose to circulating glucose.
Jandrain, Bernard ULg; Pallikarakis, N.; Normand, S. et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1993), 74(5), 2146-54

The aim of the present study was to compare the metabolic fate of repeated doses of fructose or glucose ingested every 30 min during long-duration moderate-intensity exercise in men. Healthy volunteers ... [more ▼]

The aim of the present study was to compare the metabolic fate of repeated doses of fructose or glucose ingested every 30 min during long-duration moderate-intensity exercise in men. Healthy volunteers exercised for 3 h on a treadmill at 45% of their maximal oxygen consumption rate. "Naturally labeled" [13C]glucose or [13C]fructose was given orally at 25-g doses every 30 min (total feeding: 150 g; n = 6 in each group). Substrate utilization was evaluated by indirect calorimetry, and exogenous sugar oxidation was measured by isotope ratio mass spectrometry on expired CO2. Results were corrected for baseline drift in 13C/12C ratio in expired air due to exercise alone. Fructose conversion to plasma glucose was measured combining gas chromatography and isotope ratio mass spectrometry. Most of the ingested glucose was oxidized: 81 +/- 4 vs. 57 +/- 2 g/3 h for fructose (2P < 0.005). Exogenous glucose covered 20.8 +/- 1.4% of the total energy need (+/- 6.7 MJ) compared with 14.0 +/- 0.6% for fructose (2P < 0.005). The contribution of total carbohydrates was significantly higher and that of lipids significantly lower with glucose than with fructose. The blood glucose response was similar in both protocols. From 90 to 180 min, 55-60% of circulating glucose was derived from ingested fructose. In conclusion, when ingested repeatedly during moderate-intensity prolonged exercise, fructose is metabolically less available than glucose, despite a high rate of conversion to circulating glucose. [less ▲]

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See detailStructure of the apolipoprotein A-IV/lipid discoidal complexes: an attenuated total reflection polarized Fourier transform infrared spectroscopy study.
Lins, Laurence ULg; Brasseur, Robert ULg; Rosseneu, M. et al

in Biochimica et Biophysica Acta (1993), 1149(2), 267-77

Discoidal lipid particles were prepared from a reaction mixture containing apo A-IV and dimyristoylphosphatidylcholine (DMPC) or dipalmitoylphosphatidylcholine (DPPC) in the molar ratio of 185:1 (lipid ... [more ▼]

Discoidal lipid particles were prepared from a reaction mixture containing apo A-IV and dimyristoylphosphatidylcholine (DMPC) or dipalmitoylphosphatidylcholine (DPPC) in the molar ratio of 185:1 (lipid/protein). The complexes were isolated by gel filtration and characterized in terms of composition and size. Infrared attenuated total reflection spectroscopy was used to estimate the secondary structure of apolipoprotein A-IV and the orientation of its amphipathic alpha-helices with respect to the lipid hydrocarbon chains. In addition, infrared spectra were analyzed in terms of the conformation and organization of different regions of the lipid molecules in the particles. This approach has been applied successfully to reconstituted HDL particles prepared from a reaction mixture containing DPPC and apo A-I in the molar ratio of 150:1 (Wald, J.H., Goormaghtigh, E., De Meutter, J., Ruysschaert, J.M. and Jonas, A. (1990) J. Biol. Chem. 265, 20044-20050). Apo A-IV helicity increased for the protein bound to DMPC or DPPC but the increase was more pronounced for the apo A-IV/DMPC particles. In both complexes, the alpha helical amphipathic segments of the protein were parallel to the lipid acyl chains and no significant modification of the overall organization of the lipid molecules in the lipid bilayer was observed. The presence of apo A-IV seems only to affect the conformation of the lipid hydrocarbon chains in close contact with the protein in the discoidal particles. [less ▲]

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See detailBiological control of postharvest Botrytis cinerea and Penicillium on apples
Jijakli, Haissam ULg; Lepoivre, Philippe ULg

in Bulletin OILB/SROP = IOBC/WPRS Bulletin (1993), (16), 106-110

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See detailExiste-t'il une Europe de l'épargne?
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Reflets et Perspectives de la Vie Economique (1993), (32), 37-59

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See detailEffects of Neurochemical Lesions of the Preoptic Area on Male Sexual Behavior in the Japanese Quail
Bailhache, T.; Surlemont, C.; Balthazart, Jacques ULg

in Brain Research Bulletin (1993), 32(3), 273-83

Two experiments were carried out during which the noradrenergic neurotoxin, 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine (5-ADMP) was applied to the brain of quail in order to evaluate the role of ... [more ▼]

Two experiments were carried out during which the noradrenergic neurotoxin, 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine (5-ADMP) was applied to the brain of quail in order to evaluate the role of the noradrenergic system in the control of male copulatory behavior. In the first experiment, the ICV injection of 5-ADMP slightly enhanced the sexual behavior observed in testosterone (T)-treated castrated male quail. This brings additional support to the notion that norepinephrine tonically inhibits male copulatory behavior in quail. In the second experiment, 5-ADMP implanted directly into the preoptic area disrupted the restoration by T of copulatory behavior in castrated quail and, at the same time, produced a brain lesion that partly destroyed the sexually dimorphic medial preoptic nucleus, a previously established site of T action on behavior. These lesions produced by a high (presumably too high) concentration of neurotoxin provided an independent confirmation of effects previously observed after electrolytic lesions. Correlation analyses also confirmed that the medial part of the POM just rostral to the anterior commissure is more closely associated with copulatory behavior and may, therefore, represent a key center for steroid action on this behavior. [less ▲]

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See detailReturn interval, firm size and systematic risk on the Dutch stock market
Corhay, Albert ULg; Tourani-Rad, Alireza

in Review of Financial Economics (1993), 2(2), 19-28

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See detailSequence of the triosephosphate isomerase-encoding gene isolated from the thermophile Bacillus stearothermophilus
Rentier-Delrue, Françoise ULg; Moyens, Sylvianne; Lion, Michelle ULg et al

in Gene (1993), 134(1), 137-8

By analysis of genomic clones, we have determined the complete nucleotide sequence of the gene encoding triosephosphate isomerase (TIM; EC 5.3.1.1) in the thermophilic bacterium, Bacillus ... [more ▼]

By analysis of genomic clones, we have determined the complete nucleotide sequence of the gene encoding triosephosphate isomerase (TIM; EC 5.3.1.1) in the thermophilic bacterium, Bacillus stearothermophilus. The gene encodes a 253-amino-acid TIM which is 39% identical to that of the mesophile, Escherichia coli. [less ▲]

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See detailKonie pociagowe ardenskie
Burny, Philippe ULg; Lebailly, Philippe ULg; Ensch, D. et al

in Przeglad Hodowlany (1993), (3/1993), 21-22

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See detailUltrastructural distribution of DNA and RNA within the nucleolus of human Sertoli cells as seen by molecular immunocytochemistry.
Thiry, Marc ULg

in Journal of Cell Science (1993), 105 ( Pt 1)

The precise distribution of DNA and RNA within the human Sertoli cell nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. In Sertoli ... [more ▼]

The precise distribution of DNA and RNA within the human Sertoli cell nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. In Sertoli cells, the nucleolar components show a typical spatial distribution. The fibrillar centres are not surrounded by a layer of dense fibrillar component, but come in contact only with strands of dense fibrillar component. These fibrillar parts of strands are the extensions of granular strands connected to a large granular mass. These strands delimit numerous nucleolar interstices in which chromatin fibres are clearly obvious. Using the in situ terminal deoxynucleotidyl transferase/immunogold procedure for detecting DNA, we find evident label exclusively over the chromatin fibres enclosed in the nucleolar interstices and over the fibrillar centres, and no significant label over the dense fibrillar component and granular component of the nucleolus. Furthermore, using the polyadenylate nucleotidyl transferase/immunogold procedure for detecting RNA, we show that label is deposited not only over the granular component and dense fibrillar component, as expected, but also quite obviously over the fibrillar centres. No label is seen over the interstices containing chromatin. [less ▲]

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See detailApplying the Lagamine model to compute land subsidence in Shanghai
Dassargues, Alain ULg; Schroeder, Christian ULg; Li, Xiang Lin

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailLaparoscopic surgery, urology and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailLocalisation scintigraphique de tumeurs neuroendocrines et de leurs métastases par un analogue de la somatostatine: [111In-DTPA-d-phe1] octréotide.
Beckers, Albert ULg; Pham, V. T.; Abs, R. et al

in Revue Médicale de Liège (1993), 48(6), 326-34

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See detailSurgical Technique for Cardiomyoplasty and Iterative Transthoracic Biopsies in an Experimental Goat Model
Radermecker, M. A.; Fourny, J.; Bonnet, Pierre ULg et al

in European Surgical Research = Europäische Chirurgische Forschung = Recherches Chirurgicales Européennes (1993), 25(2, Mar-Apr), 110-22

Cardiomyoplasty is a new surgical procedure using transformed skeletal muscle to reinforce or substitute for the myocardium. For the purpose of studying surgical technique and investigating basic ... [more ▼]

Cardiomyoplasty is a new surgical procedure using transformed skeletal muscle to reinforce or substitute for the myocardium. For the purpose of studying surgical technique and investigating basic questions, we have developed a model of reinforcement cardiomyoplasty. Herein, we describe anesthetic management, surgical technique, and the technique for iterative transthoracic biopsies. This model has proven to be valuable in several long-term studies involving more than 30 goats. Preliminary data to ascertain the efficacy of the proposed technique are provided. [less ▲]

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See detailTypes de circulation atmosphériques, advection des masses d'air et variations climatiques: Le cas des hivers doux et des hivers rudes récents en Belgique
Erpicum, Michel ULg; Mabille, Georges ULg; Alexandre, Jean ULg

in Publications de l'Association Internationale de Climatologie (1993), 6

In Belgium, air masse advections -as it appears at 850 hPa level- are very important for the explanation of the surface air temperature of mild winters. Nevertheless in case of severe winters, radiative ... [more ▼]

In Belgium, air masse advections -as it appears at 850 hPa level- are very important for the explanation of the surface air temperature of mild winters. Nevertheless in case of severe winters, radiative conditions observed at tropospheric lower level and horizontal motion of very thin air masses (below 850 hPa level) seem to be more important for the explanation of ground level temperature. [less ▲]

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See detailApplying the Meridional Streamfunction Visualization Technique to Open Ocean Domains
Deleersnijder, E.; Beckers, Jean-Marie ULg

in Ocean Modelling (1993), 101

It is common practice to represent by streamfunction the transport field ensuing from the integration - over one horizontal coordinate - of the velocity field predicted by ocean models. This very useful ... [more ▼]

It is common practice to represent by streamfunction the transport field ensuing from the integration - over one horizontal coordinate - of the velocity field predicted by ocean models. This very useful visualization technique requires that the transport field be divergenceless. If this is not the case, it is suggested to extract the divergenceless transport field that is closest to that stemming from the model while verifying the impermeability conditions of the ocean surface and bottom. A variational approach is examined. [less ▲]

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See detailLaminin Receptors and Laminin-Binding Proteins During Tumor Invasion and Metastasis
Castronovo, Vincenzo ULg

in Invasion & Metastasis (1993), 13(1), 1-30

Interactions between cancer cells and laminin, a major component of basement membranes, play a critical role at several steps of the complex process of tumor invasion and metastasis. These interactions ... [more ▼]

Interactions between cancer cells and laminin, a major component of basement membranes, play a critical role at several steps of the complex process of tumor invasion and metastasis. These interactions are mediated through a large variety of cell surface proteins designated as laminin receptors and/or laminin-binding proteins. The growing number of identified laminin binding proteins and domains of this glycoprotein that are biologically active illustrate the complexity of cellular interactions with laminin. The 67-kD laminin receptor (67 LR) was the first protein identified in 1983 as a high-affinity laminin receptor, and its expression is dramatically increased in a large variety of cancer cells. The 67 LR is the subject of several controversies and confusion generated mainly by two events. First, the identification of several new laminin-binding proteins has raised the difficult task of attributing specific functions to specific receptors in contrast to initial beliefs that all cellular laminin-driven biological activities were mediated through the 67 LR. The second source of controversy is the large molecular-weight discrepancy between the 37-kD polypeptide encoded by the 67 LR cDNA clone and the mature 67 LR. In this manuscript, a critical and extensive review of the data accumulated on the 67 LR is presented regarding both its molecular structure and its role during tumor invasion and metastasis. A hypothetical model of the 67 LR is also proposed. Since the first identification of the 67 LR, at least 14 other cell surface molecules have been reported to be potential laminin receptors or laminin-binding proteins. These include members of the beta-galactoside-binding lectin family, seven members of the integrin family, the galactosyltransferase and some not yet fully characterized cell surface molecules. These laminin receptors and laminin-binding proteins are also described and their functions are also discussed with a particular emphasis on their participation in the constitution of the invasive phenotype. [less ▲]

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See detailSub-mesoscale Air-sea Interactions
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Journal of Marine Systems (1993), 4(2-3),

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1993), n°1

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See detailChylothorax: a rare complication of endoscopic variceal sclerotherapy.
Bury, Thierry ULg; Corhay, Jean-Louis ULg; Louis, Renaud ULg et al

in European Journal of Gastroenterology & Hepatology (1993), 5

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See detailOkadaic acid, a protein phosphatase inhibitor, enhances transcription of a receptor gene containing sequence A of the human prolactin promoter
Wera, S.; Belayew, A.; Martial, Joseph ULg

in Molecular Endocrinology (1993), 7(8), 965-71

Human PRL (hPRL) gene expression is controlled by cAMP and Ca2+. This control is mediated by two cis-elements: a Pit-1 binding site (-62 to -35) and sequence A (-110 to -85), present in the hPRL promoter ... [more ▼]

Human PRL (hPRL) gene expression is controlled by cAMP and Ca2+. This control is mediated by two cis-elements: a Pit-1 binding site (-62 to -35) and sequence A (-110 to -85), present in the hPRL promoter. We have investigated whether protein phosphatases could be involved in this regulation. GC-type rat pituitary tumor cells were transfected with sequence -138 to -35 of the hPRL gene promoter, upstream from a thymidine kinase promoter and a chloramphenicol acetyltransferase (CAT) reporter gene. Addition of okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, stimulates transient expression of the CAT gene. The dose-response curve shows a maximal effect at 25 nM OA (2.2-fold stimulation above controls). The OA effect is also observed with a natural 4500-base pair hPRL promoter. A single copy of the hPRL promoter sequence -115 to -85 (sequence A) confers to a thymidine kinase-CAT construct an identical response to OA, whereas a single copy of the proximal Pit-1 binding site does not. Synergism is observed between cAMP and OA in activating PRL gene transcription. This synergism is also observed with a single copy of sequence A. The effect of cAMP is not mediated by an L-type Ca2+ channel, since addition of the Ca2+ channel antagonist verapamil does not decrease it, nor does complexing extracellular Ca2+ significantly reduce it. Furthermore, OA and the Ca2+ channel opener BAY K8644 exert additive effects. [less ▲]

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See detailFurther studies on the genetic diversity of lima beans (Phaseolus lunatus L.) using allozymes
Maquet, Alain; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Annual Report of the Bean Improvment Cooperative (1993), 36

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See detailBPDZ 44: a new and potent activator of ATP-sensitive K+ channels
Lebrun, P.; Pirotte, Bernard ULg; Antoine, M.-H. et al

in Diabetologia (1993), 36

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See detailSaving behavior in 17 OECD countries
Kessler, Denis; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Review of Income and Wealth (1993), (39), 37-50

This article compares savings behavior in a sample of 17 OECD countries over 24 years. On the basis of an analysis of variance and of a life-cycle-hypothesis-based equation, we test the homogeneity of ... [more ▼]

This article compares savings behavior in a sample of 17 OECD countries over 24 years. On the basis of an analysis of variance and of a life-cycle-hypothesis-based equation, we test the homogeneity of households' savings behavior. It appears that one cannot really speak of a homogeneous saving behavior across countries. This is a relevant finding in times of increasing economic and financial integration. [less ▲]

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See detailTransmission, Recombination and Conversion of Mitochondrial Markers in Relation to the Mobility of a Group I Intron in Chlamydomonas
Remacle, Claire ULg; Matagne, René-Fernand ULg

in Current Genetics (1993), 23(5-6, May-Jun), 518-25

Mitochondrial DNA transmission has been analyzed in diploids produced from sexual crosses or artificial fusions between Chlamydomonas strains which differ by several genetic markers: a group I intron (Cs ... [more ▼]

Mitochondrial DNA transmission has been analyzed in diploids produced from sexual crosses or artificial fusions between Chlamydomonas strains which differ by several genetic markers: a group I intron (Cs cob. 1 or alpha intron), three restriction sites (Nh, Nc and H markers) located 0.5-5 kb from the insertion site of the intron, and a MUD2 point mutation (27 bp from the insertion site) conferring resistance to myxothiazol. Recombination between mitochondrial markers is a general property of all crosses and fusions analyzed. In crosses between two intron-containing (alpha+) strains or two intron-less (alpha-) strains, the transmission is preferentially paternal (mt-), with a preponderance depending on the nature of the parental genomes. In crosses between alpha+ and alpha- strains, the conversion of intron-less molecules intron+ is frequent when the alpha+ parent is maternal (mt+) and nearly absolute when the alpha+ parent is paternal (mt-). In 94% of cases, the conversion is accompanied by the co-conversion of the MUD2 marker. In both crosses and artificial fusions, the conversion of alpha- into alpha+ also influences the transmission of the more distant Nh, Nc and H markers. It is hypothesized that the more frequent transmission of the genome containing the intron results from the elimination of alpha- molecules, as a result of a double-strand cut which is induced by an endonuclease encoded by the intron. [less ▲]

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See detailLog jam effect on bed-load mobility from experiments conducted in a small gravel-bed channel
Assani, Ali; Petit, François ULg

in Memorial symposium Pro. J. De Ploey Experimental geomorphology and landscape ecosystem changes (1993)

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See detailMonoclonal-Antibodies To Bovine Growth-Hormone Potentiate Hormonal Activity In-Vivo By Enhancing Growth-Hormone Binding To Hepatic Somatogenic Receptors
Massart, Serge; Maiter, D.; Portetelle, Daniel ULg et al

in Journal of Endocrinology (1993), 139(3),

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See detailA method of comparison of two close batches data: Application to analysis of fog formation causes
Boreux, Jean-Jacques ULg; Guiot, Joël

in Geophysical Research Letters (1993), 20(12), 1179-1182

Given suitable conditions of air temperature and humidity, the density of a fog and its microphysical properties depend mainly on the availability of cloud condensation nuclei (CCN) and their nature. Fogs ... [more ▼]

Given suitable conditions of air temperature and humidity, the density of a fog and its microphysical properties depend mainly on the availability of cloud condensation nuclei (CCN) and their nature. Fogs become particularly dense near certain industrial plants because of high concentration of hygroscopic combustion particles in the air. Their role in dense fog formation is estimated by comparing the local climates and CCN concentrations at two similar sites, the first being more subject to air pollution and dense fogs than the second. Orthogonal regression is applied to three meteorological variables (air temperature, relative humidity, wind speed) and CCN concentration. As we compare very close variables, bootstrap provides precise confidence intervals independent of Gaussian assumptions. Two sites are compared: they are located in the Meuse valley (Belgium) at a distance of about 15 km. We found that the local climate of the polluted site is not only colder and wetter but also richer in CCN that the control site. These results suggest interactions of natural and anthropogenic causes in dense fog formation at industrial site. This method is useful in various domains of geophysics when correlated time series have to be compared. [less ▲]

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See detailDynamics of mitotic activity and expression of viral proteins gp51 and p24 of Bovine Leukemia Virus producing cells.
Roussev, Roussi; Polianova, M.; Portetelle, Daniel ULg et al

in Folia Biologica (1993), 39

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See detailL'antiquité classique comme source d'inspiration dans l'oeuvre de Karel Tchapek
Mouton, Charles ULg

in Slavica Gandensia (1993), 20

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See detailMesures quantitatives de l'erythropoiese. Le recepteur soluble de la transferrine.
Beguin, Yves ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1993), 148(1-2), 100-4105-7

Iron transport in plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor. The soluble form of the transferrin receptor has been ... [more ▼]

Iron transport in plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor. The soluble form of the transferrin receptor has been identified in plasma. Dosage of the soluble receptor represents a simple, reliable, quantitative assay of erythropoiesis, which should replace the standard ferrokinetic measurement. Using this dosage, it is now possible to investigate the pathophysiology of anemia in many conditions, and to analyze the erythropoietic response to treatment with recombinant erythropoietin. [less ▲]

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See detailInteraction between the 67 kilodalton metastasis-associated laminin receptor and laminin.
Cioce, V.; Margulies, I. M.; Sobel, M. E. et al

in Kidney International (1993), 43(1), 30-7

Normal and neoplastic cells interact with laminin via a variety of cell surface proteins. The specific binding sites on laminin for each particular cell surface laminin-binding protein have not yet been ... [more ▼]

Normal and neoplastic cells interact with laminin via a variety of cell surface proteins. The specific binding sites on laminin for each particular cell surface laminin-binding protein have not yet been identified. In this study, the interaction between laminin and the high affinity metastasis-associated 67 kD laminin receptor (67 LR) was investigated by electron microscopy using the rotary shadowing technique. Laminin receptor that was purified from human colon carcinoma metastases appeared as a globular structure with a diameter of 5.2 +/- 0.8 nm. The 67 LR specifically bound to laminin on its long arm close to the intersection of the long and the short arms. There was no specific interaction of bovine serum albumin with laminin. Biochemical confirmation of the rotary shadowing experiments included slot blot solid phase assays in which [I125]-labeled 67 LR bound in a dose dependent manner to laminin as well as to the chymotrypsin resistant (C1) fragment of laminin that contains a short piece of the long arm. [I125]-labeled 67 LR did not bind to the pepsin resistant (P1) fragment of laminin that did not contain that segment on the long arm. This study therefore identifies the binding site on laminin for the 67 kD metastasis-associated laminin receptor as a region on the long arm of laminin close to the intersection of the four arms. [less ▲]

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See detailOnce daily administration of amikacin. Adaptation to neonatology for infants less than 3 days of postnatal age
Battisti, Oreste ULg

in Médecine et Maladies Infectieuses (1993), 23

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See detailImprovement Yarrowia lipolytica lipase production by mutant selection.
Destain, Jacqueline ULg; Roblain, D.; Thonart, Philippe ULg

in Archives Internationales de Physiologie et de Biochimie (1993), 101(B1-B25),

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See detailLa descendance de celt. *AKARNOS en wallon
Boutier, Marie-Guy ULg

in Revue de Linguistique Romane (1993)

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See detailNeutrophilic Eccrine Hidradenitis. A Case Report
Nikkels, Arjen ULg; Hansen, Isabelle ULg; Collignon, Jacques ULg et al

in Acta Clinica Belgica (1993), 48(6), 397-400

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old ... [more ▼]

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old woman with acute myeloblastic leukemia under daunorubicin, cytarabine and etoposide chemotherapy. She developed red, tender and painful nodules on a shoulder. The lesions resolved spontaneously. Histological examination is mandatory as the clinical presentation of this dermatosis is highly polymorphic. Leukemia cutis, sepsis, deep fungal infection and Sweet's syndrome must be excluded as these implicate different therapies. [less ▲]

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See detailPolarization-corrected electrostatic potentials of aromatic compounds
Dehareng, Dominique ULg; Dive, Georges ULg; Ghuysen, Jean-Marie ULg

in Journal of the American Chemical Society (1993), 115(15), 6877-6882

The electrostatic potentials (EPS) corrected for polarization (TPS) of the aromatic compounds benzene, aniline, chlorobenzene, nitrobenzene, phenol, benzamide, and N-phenylacetamide have been calculated ... [more ▼]

The electrostatic potentials (EPS) corrected for polarization (TPS) of the aromatic compounds benzene, aniline, chlorobenzene, nitrobenzene, phenol, benzamide, and N-phenylacetamide have been calculated at the ab initio SCF level within three basis sets: 6-31G**, MINI-1, and STO-3G. For chlorobenzene in its MINI-1-optimized geometry, the calculation was also performed within MINI-1**. By reference to 6-31G**, the MINI-1-computed EP is much more satisfactory than the STO-3G-computed EP, whereas the MINI-I and STO-3G basis sets give very similar total potentials corrected for polarization (TPs). The MINI-1** basis set appears to be miscalibrated for computing EPs. It provides qualitative results that differ from those obtained with the 6-31G** basis set. The EP has a negative well above the middle of the benzene ring, while the TP exhibits a negative crown just above the benzene carbon atoms, where electrophilic attack takes place. The TP calculated for the interaction of nitrobenzene with a hydride ion instead of a proton allowed analyzation of the effects of polarization on the positive EP above the N-C bond. [less ▲]

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See detailL’enquête nationale sur les effectifs du cheptel au Burkina Faso
Bahili, Jean; Djaby, Bakary ULg

in Stateco (1993), 73

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See detailDes inscriptions de sceaux-cylindres diverses provenant d'Acemhöyük
Tunca, Önhan ULg

in Aspects of Art and Iconography: Anatolia and its Neighbors. Studies in Honor of Nimet Özgüç (1993)

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See detailTransforming growth factor ß as a neuronoglial signal during peripheral nervous sytem response to injury.
Rogister, Bernard ULg; Delrée, P.; Leprince, Pierre ULg et al

in Journal of Neuroscience Research (1993), 34

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See detailNeurotransmitter phenotype plasticity in adult dorsal root ganglia neurons
Moonen, Gustave ULg; Delrée, P.; Martin, Didier ULg et al

in Restorative Neurology & Neuroscience (1993), 5

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See detail"Influence of bioreactor aeration conditions on sporulation rate of Bacillus subtilis (b 213 stream)"
Meurisse, E.; Hbid, Ch.; Jacques, Ph. et al

in Mededelingen - Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent (1993), 58(4b), 1985-1987

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See detailUltrastructural distribution of DNA within the ring-shaped nucleolus of human resting T lymphocytes.
Vandelaer, M.; Thiry, Marc ULg; Goessens, Guy ULg

in Experimental Cell Research (1993), 205(2), 430-2

The precise distribution of DNA within the resting human T lymphocyte nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. The ... [more ▼]

The precise distribution of DNA within the resting human T lymphocyte nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. The nucleolus is partially enveloped by a layer of condensed chromatin which, at several places, penetrates into the nucleolar body until in close contact with the fibrillar centers. Morphometric analysis reveals that 32% of the fibrillar center surface is essentially occupied by condensed chromatin. Using the in situ terminal deoxynucleotidyl transferase-immunogold procedure for detecting DNA, we further show that evident label is exclusively found over the condensed chromatin and over the fibrillar centers, whereas no significant label is detected over the dense fibrillar component of the nucleolus. [less ▲]

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See detailMesurer les compétences en lecture: Apports et limites d'une enquête internationale
Lafontaine, Dominique ULg

in Lettre de la DFLM (La) (1993), 12

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See detailThe distensibility of the central bronchial system in calves measured by means of the monofrequency oscillation technique
Reinhold, P.; Barnikol, W. K. R.; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40

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See detailBiological control of Botrytis cinerea and Penicillium sp. on post-harvest apples two antagonist yeasts.
Jijakli, Haissam ULg; Lepoivre, Philippe ULg; Tossut, P. et al

in Mededelingen - Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent (1993), 58(3b),

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See detailVers une optimalisation de la formation langagière de futurs cadres: une expérience en semi-autonomie à la K.U.Leuven
Sanctobin, V.; Slootmaekers, A.; Vanden Berghe, Kristine ULg et al

in Association Belge de Linguistique Appliquée Papers (1993), 15

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See detailAspects cliniques de la neoplasie endocrinienne multiple de type 1 (NEM-1).
Ghuysen, Alexandre ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in Revue Médicale de Liège (1993), 48(6), 309-63

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See detailPotentialités de modulation de la réaction inflammatoire
Delannoy, I.; Miossec, P.; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1993), 137

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See detailSoluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia.
Beguin, Yves ULg; Lampertz, S.; De Groote, D. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(12), 2019-2025

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL ... [more ▼]

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL) and evaluated them in relation to clinical and biological parameters of the disease, as well as serum immunoglobulin E (IgE). Compared to 31 normal individuals, 42 CLL patients had increased levels of sCD23 (98.4 +/- 127.7 versus 0.9 +/- 0.3 U/ml, p < 0.001), sIL-2R (6080 +/- 7030 versus 1420 +/- 640 pg/ml, p < 0.001), sTfR (12,100 +/- 11,250 versus 5000 +/- 1050 ng/ml, p < 0.001), and sCD8 (510 +/- 191 versus 234 +/- 89 U/ml, p < 0.001), but normal sCD4 levels. Mean sCD23 levels remained normal in patients with non-Hodgkin's lymphoma (other than small lymphocytic), Hodgkin's disease, hairy cell leukemia, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), multiple myeloma, or solid tumors. Advancing Rai clinical stage was associated with a progressive elevation of sCD23 (p < 0.001), while sCD8 (p < 0.05), sIL-2R (p < 0.001), and sTfR (p < 0.005) were highest in stage 2 patients. Discriminant analysis confirmed the value of soluble receptor determinations in the clinical evaluation of CLL patients. sCD23 correlated with sIL-2R (p < 0.001) and sTfR (p < 0.05) but not with sCD4 or sCD8, and displayed an inverse relationship with serum IgE (NS) and total gamma-globulin (p < 0.05). sIL-2R correlated with sCD23 (p < 0.001), sTfR (p < 0.001), sCD4 (p < 0.01), and sCD8 (p < 0.01). The lymphocyte count correlated with serum lactate dehydrogenase (LDH) (p < 0.05), sCD23 (p < 0.001) and sIL-2R (p < 0.01) but not sTfR, sCD8, or sCD4. Chemotherapy produced consistent reductions of sCD23 levels in two responding patients. We conclude that: (i) sCD23 is considerably elevated in CLL, correlates with the tumor mass and clinical stage, and could be helpful in monitoring these patients; and (ii) sIL-2R, sCD8, and sTfR levels are less specifically increased and could be influenced by other factors such as immune activation and erythropoiesis. [less ▲]

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See detailMicroclimat et composition de l'air dans une enceinte fermée destinée à l'étude de la toxicité des polluants atmosphériques chez le porcelet
Urbain, B.; Gustin, Pascal ULg; Prouvost, J. F. et al

in Veterinary Research (1993), 24(6), 503-514

An experimental model representing the pollution background in a pigpen was constructed in order to study the toxicology of pig respiratory air pollutants. Temperature, relative humidity, air-flow rate ... [more ▼]

An experimental model representing the pollution background in a pigpen was constructed in order to study the toxicology of pig respiratory air pollutants. Temperature, relative humidity, air-flow rate, total dust, total viable particles, endotoxins in respirable dust (< 5 microns) and ammonia were measured in a 1.9 m3 environmental chamber designed for piglets. The activity of 1 piglet was recorded on video. Temperature and relative humidity were respectively 23.9 +/- 1.3 degrees C and 70.5 +/- 8.3% (mean +/- SD). Air flow rate was 10 m3/h. Dust, viable particles, endotoxin and ammonia concentrations were respectively 7 +/- 2 particles/ml, 3.4 x 10(4) +/- 2.9 x 10(4) BCFP (bacterial colony-forming particles)/m3, 4.8 +/- 1.5 ng/m3 and 6 +/- 0.8 ppm (mean +/- SD). All these parameters were comparable to the lowest values recorded in pigpens [less ▲]

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