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See detailEffects of trace metals on mouse B16 melanoma cells in culture
Bahbouth, Eliane; Siwek, Brigitte; Gillet, Marie-Claire ULg et al

in Biological Trace Element Research (1993), 36(2), 191-201

The effects of fourteen metal ions on B16 cell proliferation, differentiation and melanogenesis have been analysed.

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See detailDecision tree approaches to voltage security assessment
Van Cutsem, Thierry ULg; Wehenkel, Louis ULg; Pavella, Mania ULg et al

in IEE Proceedings - Generation, Transmission & Distribution (1993), 140

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See detailLes formes normes d’ordres,
Pays, Isabelle ULg

in Journal of Algebra (1993), 155

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See detailStructure sociologique de l'élecotrat écologiste en Wallonie : une première exploration
Jacquemain, Marc ULg; Vandekeere, Michel; Doutrelepont, René

in Res Publica (1993), 25

The paper describes the main characteristics of ecological constituency through results of surveys. It shows how ecologist voter differ sharply from the rest of the population beeing much younger and much ... [more ▼]

The paper describes the main characteristics of ecological constituency through results of surveys. It shows how ecologist voter differ sharply from the rest of the population beeing much younger and much more educated, e.a. [less ▲]

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See detailStructure of the 16 S ribosomal RNA of the thermophilic cyanobacterium Chlorogloeopsis HTF (‘Mastigocladus laminosus HTF’) strain PCC75 18, and phylogenetic analysis
Wilmotte, Annick ULg; Van Der Auwera, Gert; De Wachter, Rupert

in FEBS Letters (1993), 317

The thermophilic cyanobacterial strain, PCC7518, originally identified as ‘Mu~tigocludus hminosus HTF’ does not show branchings or heterocysts. The absence of branchings supports the later assignment to ... [more ▼]

The thermophilic cyanobacterial strain, PCC7518, originally identified as ‘Mu~tigocludus hminosus HTF’ does not show branchings or heterocysts. The absence of branchings supports the later assignment to the genus Chlorogloeopsu. The absence of heterocysts may be the result of a mutation because heterocysts were observed in the original isolate. Alternatively, contamination may have happened. To solve this problem, the 16 S rRNA sequence was determined and used to infer a secondary structure model and build distance trees. The trees showed that strain PCC7518 belongs to the cluster of heterocystous species and has most probably lost the abihty to produce heterocysts by mutation. It is only distantly related to Chlorogloeopsis fritschii PCC67 18. [less ▲]

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See detailLe nom du bison en grec et en latin
Purnelle, Gérald ULg

in Latomus : Revue d'Etudes Latines (1993), 52(3), 567-580

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See detailHyperlipidemies et medicaments hypolipidemiants.
Scheen, André ULg; Paquot, Nicolas ULg

in Journal de Pharmacie de Belgique (1993), 48(2), 92-101

Hyperlipidaemia, as a primary atherogenic risk factor, represents a major problem of public health. This review first reminds the main steps of lipoprotein metabolism, the classification of the most ... [more ▼]

Hyperlipidaemia, as a primary atherogenic risk factor, represents a major problem of public health. This review first reminds the main steps of lipoprotein metabolism, the classification of the most frequent hyperlipidaemias, the objectives of the treatment and the required initial evaluation allowing to decide how to manage the patient. Thereafter, it describes all the available treatments, more particularly the characteristics of the various lipid lowering drugs. Finally, it proposes a step by step strategy for the treatment of the main hyperlipidaemias and summarizes the managements of some particular cases. [less ▲]

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See detailAspects cliniques de la neoplasie endocrinienne multiple de type 1 (NEM-1).
Ghuysen, Alexandre ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in Revue Médicale de Liège (1993), 48(6), 309-63

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See detailMonth-to-month variability of the general circulation fields in the western Mediterranean and the Gulf of Lions
Beckers, Jean-Marie ULg; Brasseur, P.

in Water Pollution Research (1993), 30

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See detailAccurate f-values of Astrophysical Interest in neutral Carbon
Hibbert, A.; Biémont, Emile ULg; Godefroid, M. et al

in Astronomy and Astrophysics. Supplement Series (1993), 99

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See detailMapping Of B-Neutralizing And T-Helper Cell Epitopes On The Bovine Leukemia-Virus External Glycoprotein Gp51
Callebaut, I.; Voneche, V.; Mager, A. et al

in Journal of Virology (1993), 67(9),

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See detailAspects cliniques de la neoplasie endocrinienne multiple de type 2 (NEM-2).
Moreau, L.; Beckers, Albert ULg

in Revue Médicale de Liège (1993), 48(6), 316-22

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See detailHemodynamic changes during laparoscopic cholecystectomy.
Joris, Jean ULg; Noirot, Didier P; Legrand, Marc ULg et al

in Anesthesia and Analgesia (1993), 76(5), 1067-71

Hemodynamics during laparoscopic cholecystectomy under general anesthesia (isoflurane in N2O/O2 (50%)) were investigated in 15 nonobese ASA Class I patients by using invasive hemodynamic monitoring ... [more ▼]

Hemodynamics during laparoscopic cholecystectomy under general anesthesia (isoflurane in N2O/O2 (50%)) were investigated in 15 nonobese ASA Class I patients by using invasive hemodynamic monitoring including a flow-directed pulmonary artery catheter. During surgery, intraabdominal pressure was maintained automatically at 14 mm Hg by a CO2 insufflator, and minute ventilation was controlled and adjusted to avoid hypercapnia. Hemodynamics were measured before anesthesia, after the induction of anesthesia, after tilting into 10 degrees head-up position, 5 min, 15 min, and 30 min after peritoneal insufflation, and 30 min after exsufflation. Induction of anesthesia decreased significantly mean arterial pressure and cardiac index (CI). Tilting the patient to the head-up position reduced cardiac preload and caused further reduction of CI. Peritoneal insufflation resulted in a significant increase (+/- 35%) of mean arterial pressure, a significant reduction (+/- 20%) of CI, and a significant increase of systemic (+/- 65%) and pulmonary (+/- 90%) vascular resistances. The combined effect of anesthesia, head-up tilt, and peritoneal insufflation produced a 50% decrease in CI. Administration of increasing concentrations of isoflurane, via its vasodilatory activity, may have partially blunted these hemodynamic changes. These results demonstrate that laparoscopy for cholecystectomy in head-up position results in significant hemodynamic changes in healthy patients, particularly at the induction of pneumoperitoneum. [less ▲]

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See detailDetection of mRNA encoding an antibacterial-metalloprotein (MPII) by in situ hybridization with a cDNA probe generated by PCR in the worm nereis diversicolor
Salzet-Raveillon, B.; Rentier-Delrue, Françoise ULg; Dhainaut, A.

in Cellular and Molecular Biology (1993)

Based on partial amino acid sequence of an antibacterial-metalloprotein (MPII) consisting of a N-terminal fragment (1-33th) and an 43 amino acids long internal fragment, two oligonucleotides primers were ... [more ▼]

Based on partial amino acid sequence of an antibacterial-metalloprotein (MPII) consisting of a N-terminal fragment (1-33th) and an 43 amino acids long internal fragment, two oligonucleotides primers were synthesized and used to generate a cDNA fragment by the PCR method. The specificity of the PCR synthesized 220 bp fragment was verified by hybrid-arrest translation and sequencing. In situ hybridization performed with this cDNA fragment on Nereis diversicolor whole body defined two specific sites of recognition: a cluster of cells floating in the coelom and two types of muscles (perineural and oblique). Finally, the chronological expression of the MPII was postulated. [less ▲]

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See detailDRC1 expression on normal and pathological lymphoid cells.
Antoine, Nadine ULg; Heinen, Ernst ULg; Marcoty, C. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailThe Implications of European Union for the Performance of Public Enterprises
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in Administration : Journal of the Institute of Public Administration of Ireland (1993), 41(Summer), 149-165

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See detailPharmacological treatment of the obese diabetic patient.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabète & Métabolisme (1993), 19(6), 547-59

Obesity is a well-known risk factor for non-insulin-dependent (or Type 2) diabetes mellitus. Consequently, reduction of weight excess comes to the front line in the prevention and management of NIDDM. It ... [more ▼]

Obesity is a well-known risk factor for non-insulin-dependent (or Type 2) diabetes mellitus. Consequently, reduction of weight excess comes to the front line in the prevention and management of NIDDM. It is only when diet and physical exercise fail that drug treatment should be considered. Pharmacological treatment of obesity should favour drugs which not only promote weight loss, by reducing caloric intake and/or increasing thermogenesis and energy expenditure, but also, and especially, improve insulin sensitivity. Serotoninergic anorectic compounds (dexfenfluramine, fluoxetine) appear to possess, to some extent, all these properties. Metformin significantly reduces insulin resistance and improves glycaemic control without inducing weight gain, and even favouring some weight loss. This biguanide is now considered as the first line drug for the obese diabetic patient. Alpha-glucosidase inhibitors may help to reduce post-prandial glucose excursions but do not promote weight loss per se. Sulfonylureas can be prescribed to an obese patient when hyperglycaemia persists despite diet and the above-mentioned oral agents, but their use should be associated with reinforcement of dietary advices in order to prevent further weight increase; it is also the case for insulin therapy. Finally, drugs specifically stimulating thermogenesis and energy expenditure, new agents sensitizing tissues to the action of insulin and various compounds interfering with lipid metabolism are currently under extensive investigation with promising preliminary results in the obese diabetic patient. In conclusion, obesity remains a major problem in the management of Type 2 diabetes mellitus and this justifies the search for new, safe and effective, pharmacological approaches. [less ▲]

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See detailOn the Use of Distance in the Taxonomic Study of Critical Plant Groups-Case Studies of Western European Orchidaceae
Tyteca, D.; Dufrêne, Marc ULg

in Annals of Botany (1993), 71(3), 257-277

Four distance coefficients are compared on four data sets composed of samples coming from western European populations of the genera Dactylorhiza, Orchis and Epipactis (Orchidaceae). The performance of ... [more ▼]

Four distance coefficients are compared on four data sets composed of samples coming from western European populations of the genera Dactylorhiza, Orchis and Epipactis (Orchidaceae). The performance of the distance coefficients is evaluated through: (a) the quality of clusters obtained by five classical methods (as compared to a priori classification), (b) the Mantel statistic with respect to an a priori distance matrix resulting from previous knowledge, (c) the result obtained with the k-means method, and (d) principal coordinate diagrams. It appears that: (a) the Mahalanobis distance based on the pooled dispersion matrix performs best on the whole; (b) a distance based on the recently developed Common Principal Component model, used with a log transformation, also provides useful information and performs best on the largest data set; (c) the Gölz and Reinhard taxonomic distance, widely used among orchidologists, is attractive for its simplicity, yet good performance and the valuable information it provides, despite its theoretical shortcomings. A brief taxonomic discussion is made on the results obtained for the Dactylorhiza samples, especially about samples whose identification was in doubt. [less ▲]

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See detailInfections par streptocoque B en période néonatale. Epidémiologie et prévention
Battisti, Oreste ULg

in Archives Françaises de Pédiatrie (1993), 50

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See detailApplying the Lagamine model to compute land subsidence in Shanghai
Dassargues, Alain ULg; Schroeder, Christian ULg; Li, Xiang Lin

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailPurification, expansion, and multiple fluorochrome labeling of cord blood hemopoietic precursors: preliminary results.
Feron, C.; Gothot, André ULg; Grosdent, Jean-Claude ULg et al

in Journal of Hematotherapy (1993), 2(2), 259-61

CD34-positive cells were isolated from a total of 23 cords using CellPro Ceprate columns. AIS MicroCellector flasks, and panning. The cells were (1) expanded in serum-free culture supplemented with a ... [more ▼]

CD34-positive cells were isolated from a total of 23 cords using CellPro Ceprate columns. AIS MicroCellector flasks, and panning. The cells were (1) expanded in serum-free culture supplemented with a variety of combinations of cytokines and (2) immunophenotyped using multiple fluorochrome labeling. The results indicated that the avidin column produced the highest purity of CD34-positive cells, and that immature blast cells could be expanded in serum-free culture. Preliminary results suggested that the four fluorochrome labeling technique may provide useful information on the lineage commitment of cord blood precursor and blast cells. [less ▲]

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See detailIs1151, an Is-Like Element of Clostridium Perfringens
Daube, Georges ULg; Kaeckenbeeck, Albert ULg; Simon, Patricia ULg

in Nucleic Acids Research (1993), 21(2), 352

Description of a new insertion sequence, named IS1151, associated with cpe gene from Clostridium perfringens

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See detailMourir à son postmoderne
Demoulin, Laurent ULg

in Ecritures (1993), 5

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à ... [more ▼]

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à distinguer du postmodernisme (si celui-ci existe). [less ▲]

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See detailCD68 and Factor XIIIa expressions in granular-cell tumor of the skin
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1993), 186(2), 106-108

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using ... [more ▼]

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using antibodies to CD68, S-100 proteins, factor XIIIa, L1 antigen, desmin and vimentin. The CD68 monocyte-macrophage-associated lysosomal antigen was expressed in granular cells which however had no Mac 387 reactivity. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm. [less ▲]

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See detailLe rôle central du thymus dans l'éducation des cellules T aux principes neuroendocrines
Geenen, Vincent ULg

in Verhandelingen - Koninklijke Vlaamse Academie voor Geneeskunde van Belgie (1993), LV

The thymus is the site of expression of peptides belonging to the neurohypophysial peptide family. The classical model of neurosecretion established by the Scharrers for the hypothalamo-neurohypophysial ... [more ▼]

The thymus is the site of expression of peptides belonging to the neurohypophysial peptide family. The classical model of neurosecretion established by the Scharrers for the hypothalamo-neurohypophysial axis howver cannot be applied to characterize the secretory pathways of neurohypophysial-related peptides in the thymic epithelium. The novel model of cryptocrine signaling has been proposed by John W. Funder to describe the molecular relationships between fixed epithelial cells and migratory differentiating cells. In the thymus, cryptocrine signaling is further closely associated to the presentation of the 'self' molecular structure by major histocompatibility complex-derived proteins to developing T cells. Altogether, the model of the thymic repertoire of neuroendocrine self-antigens transposes to the molecular level the dual physiological role of the thymus in T cell negative and positive selection. Moreover, this model should also contribute to a better understanding of the molecular mechanisms underlying the establishment of central T-cell self-tolerance to neurodocrine functions. [less ▲]

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See detailMeningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with aids
Snoeck, R.; Gerard, M.; Sadzot-Delvaux, Catherine ULg et al

in Journal of Infectious Diseases (1993), 168(5), 1330-1331

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See detailClonidine and ketanserin both are effective treatment for postanesthetic shivering.
Joris, Jean ULg; Banache, Maryse; Bonnet, Francis et al

in Anesthesiology (1993), 79(3), 532-9

BACKGROUND: Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which ... [more ▼]

BACKGROUND: Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which shivering can be controlled. Accordingly, we investigated the efficacy of clonidine, an alpha 2-adrenergic agonist, and ketanserin, a 5-hydroxytryptamine antagonist, in treating postanesthetic shivering. METHODS: First, 54 patients shivering after general anesthesia were allocated randomly to receive an intravenous bolus of saline, 150 micrograms clonidine, or 10 mg ketanserin. A second study explored the dose-dependence of clonidine. Forty shivering patients were given saline or clonidine, 37.5, 75, or 150 micrograms. RESULTS: The duration of shivering was significantly shorter in those given clonidine (2.1 +/- 0.9 min) than in the other two groups and shorter in the ketanserin group (4.3 +/- 0.9 min) than in the saline group (12.0 +/- 1.6 min). Clonidine and ketanserin significantly decreased systolic arterial blood pressure when compared to saline. Core rewarming was significantly slower in the clonidine group. In the second study, 37.5 micrograms clonidine was no more effective than saline. Two minutes after treatment, 150 micrograms obliterated shivering in all patients. Five minutes after treatment, all patients given 75 micrograms had stopped shivering. Systolic arterial pressure and heart rate decreased significantly in patients given 75 and 150 micrograms clonidine. CONCLUSIONS: Clonidine (150 micrograms) and ketanserin (10 mg) both are effective treatment for postanesthetic shivering. The effect of clonidine on shivering is dose-dependent: whereas 37.5 micrograms had no effect, 75 micrograms clonidine stopped shivering within 5 min. [less ▲]

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See detailThe fractal nature of the power spectrum as an indicator of chaos in the Bianchi-IX cosmological model
Demaret, Jacques; De Rop, Yves ULg

in Physics Letters B (1993), 299(3-4), 223-228

Using two different methods, we compute the fractal dimension of the power spectrum associated with numerical solutions of the spatially homogeneous Bianchi IX cosmological model in Misner-Chitre ... [more ▼]

Using two different methods, we compute the fractal dimension of the power spectrum associated with numerical solutions of the spatially homogeneous Bianchi IX cosmological model in Misner-Chitre coordinates. According to Perdang's criterion, the noninteger character of this dimension is reflection of chaos and can be used to measure it, in the same spirit as the Lyapunov exponent of the Kolmogorov entropy. The results obtained indicate the chaotic nature of the behaviour of the Bianchi IX model near the cosmological singularity. [less ▲]

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See detailCHARACTERIZATION OF 3 LABDANE DITERPENES FROM AFRAMOMUM-ALBOVIOLACEUM
Marlier, Michel; LEGUELLEC, G.; Lognay, Georges ULg et al

in Planta Medica (1993), 59(5), 455-457

Two labdane diterpenes were isolated from the seeds and the rhizomes of Aframomum alboviolaceum (Ridley) K. Schum (Zingiberaceae) and identified by GC-MS, H-1-, and C-13-NMR as (E)-labda-8(17),12-diene-15 ... [more ▼]

Two labdane diterpenes were isolated from the seeds and the rhizomes of Aframomum alboviolaceum (Ridley) K. Schum (Zingiberaceae) and identified by GC-MS, H-1-, and C-13-NMR as (E)-labda-8(17),12-diene-15,16-dial (1) and (E)-8beta,17-epoxylabd-12-ene-15,16-dial (2). A third minor compound could be the methyl (E)-14xi,15-epoxylabd-8(17), 12-dien-16-oate. The simultaneous occurrence of these three molecules has been mentioned only in one other species of the same genus, Aframomum daniellii (1). [less ▲]

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See detailComputed subsidence of the central area of Shanghai
Dassargues, Alain ULg; Radu, Jean-Pol ULg; Charlier, Robert ULg et al

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailBovine leukemia virus, an animal model for the study of intrastrain variability.
Willems, Luc ULg; Thienpont, E.; Kerkhofs, P. et al

in Journal of Virology (1993), 67(2),

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See detailLa voie navigable Anvers-Dusseldorf pour une liaison Meuse-Rhine
Rigo, Philippe ULg

in Bulletin de l’Association Internationale Permanente des Congrès de Navigation [Bulletin de l'AIPCN] (1993)

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See detailInsulin secretion, clearance, and action on glucose metabolism in cirrhotic patients.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Journal of Clinical Endocrinology and Metabolism (1993), 77(5), 1263-8

To study the mechanisms of glucose intolerance and hyperinsulinism in liver cirrhosis, we compared the plasma glucose, insulin, and C-peptide levels during a frequently sampled i.v. glucose tolerance test ... [more ▼]

To study the mechanisms of glucose intolerance and hyperinsulinism in liver cirrhosis, we compared the plasma glucose, insulin, and C-peptide levels during a frequently sampled i.v. glucose tolerance test (0.3 g glucose/kg BW) in nine compensated cirrhotic patients and nine healthy volunteers well matched for age, sex, and body weight. The insulin secretion rate was derived by the deconvolution of plasma C-peptide levels, insulin sensitivity was calculated using Bergman's minimal model method, and insulin clearance was estimated by dividing the 0-180 min area under the curve of insulin secretion rate by that of peripheral plasma insulin levels. The cirrhotic patients were characterized during the frequently sampled i.v. glucose tolerance test by a 60% greater insulin secretion rate (P < 0.05), a markedly reduced insulin sensitivity index (SI; 2.82 +/- 0.75 vs. 5.86 +/- 0.68 x 10(-4) min/mU.L; P < 0.01) and a 40% reduced insulin clearance (725 +/- 169 vs. 1165 +/- 99 mL/min.m-2; P < 0.05). The reduction of insulin clearance was significantly correlated with the amplitude of the portosystemic shunt, measured using an isotopic method (r = 0.75; P < 0.02). In conclusion, cirrhosis is characterized by an important peripheral hyperinsulinism, resulting from both a higher insulin secretion rate and a reduced insulin hepatic clearance; the severe insulin resistance explains the glucose metabolism alterations. [less ▲]

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See detailIntracellular damages induced by singlet oxygen are signals for HIV-1 reactivation
Piette, Jacques ULg; Legrand-Poels, Sylvie ULg

in Journal of Free Radicals in Biology & Medicine (1993)

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See detailNEOGENE TO QUATERNARY CLAY MINERAL FLUXES IN THE CENTRAL INDIAN BASIN
DEBRABANT, P.; Fagel, Nathalie ULg; CHAMLEY, H. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (1993), 103(3-4), 117-131

The late Cenozoic clay sedimentation in the Central Indian Basin was investigated by mineralogical analyses of five very long cores (33-49 m long), which were recovered between 1-degrees and 10-degrees-S ... [more ▼]

The late Cenozoic clay sedimentation in the Central Indian Basin was investigated by mineralogical analyses of five very long cores (33-49 m long), which were recovered between 1-degrees and 10-degrees-S along a transect at about 80-degrees-E and compared with data from adjacent ODP and piston cores. Progressive changes occur from North to South, and are especially marked by a decrease of illite and chlorite amounts balanced by increased contents of smectite and kaolinite. These changes arc attributed to a southwards reduction of Himalaya-derived detrital fluxes, and to a correlative augmentation both of smectite reworked from coastal Indian, Indonesian and volcanic submarine sources, and of kaolinite supplied from Australia and blocked by the equatorial divergence. The stratigraphic changes are more diversified than the geographic changes and develop discontinuously. High fluxes of illitic and chloritic materials during the middle-late Miocene reflect major activity of the Himalayan Main Central Thrust. A tectonic relaxation developed during the latest Miocene-early Pliocene, allowing alternating supply of illite-rich and smectite-rich sediments, which suggests periodical changes from distant to more local supply partly controlled by climate and by Indian intraplate deformations. The more abundant and constant amounts of smectite in late Pliocene-early Pleistocene sediments are chiefly attributed to erosion of Indian coastal zones favored by a worldwide sea-level drop. The middle to late Quaternary increase of the illite group resulted from the resumption of the tectonic activity in the Himalaya-Tibet range associated with a general climatic cooling. [less ▲]

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See detailTotal intravenous anesthesia in South-African genetic porphyria (variegate porphyria)
Bichel, Th; Joris, Jean ULg; Jacquet, N. et al

in Acta Anaesthesiologica Belgica (1993), 44(1), 25-29

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See detailPressure effects, kinetics, and rheology of anorthositic and related magmas
Longhi, John; Fram, Miranda; Vander Auwera, Jacqueline ULg et al

in American Mineralogist (1993), 78

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See detailDynamics of erythropoietic recovery following bone marrow transplantation: role of marrow proliferative capacity and erythropoietin production in autologous versus allogeneic transplants.
Beguin, Yves ULg; Oris, Renée ULg; Fillet, Georges ULg

in Bone Marrow Transplantation (1993), 11(4), 285-92

The mechanisms of erythrocyte recovery after BMT are not known. We investigated the respective role of marrow function and erythropoietin production in 31 ABMT and 47 allogeneic BMT by analysing ... [more ▼]

The mechanisms of erythrocyte recovery after BMT are not known. We investigated the respective role of marrow function and erythropoietin production in 31 ABMT and 47 allogeneic BMT by analysing peripheral counts, serum erythropoietin levels, and serum transferrin receptor (TfR) levels which have been shown to be a quantitative measurement of erythropoiesis. Median times to complete neutrophil (25 vs 48 days, p < 0.0001) and platelet (45 vs 263 days, p < 0.001) recovery were faster after allogeneic BMT than ABMT, but complete erythrocyte recovery was slower (218 vs 101 days, p < 0.001). After ABMT, erythrocyte recovery paralleled that of neutrophils and platelets, and erythropoietin levels remained appropriate for the degree of anemia. After allogeneic BMT, erythrocytes developed independently of the other cell lines and defective erythropoietin production delayed recovery of adequate erythropoietic activity. This correlated with an alteration of renal function only in those patients remaining erythropoietin deficient beyond day 180. However, supranormal erythropoietin levels in interstitial pneumonia suggests that erythropoietin response to hypoxia is not abrogated. CMV infection could also affect erythropoiesis through erythropoietin production after ABMT as well as allogeneic BMT. It is concluded that after ABMT the development of erythropoiesis is determined by the overall marrow proliferative activity and erythropoietin plays only a facilitating role. After allogeneic BMT, erythropoiesis depends on erythropoietin levels which remain inadequate for prolonged periods of time. The results suggest that the administration of recombinant human erythropoietin could reduce transfusion requirements after BMT. [less ▲]

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See detailSTUDY OF THE CRYSTALLIZATION PROCESS IN BI2-XPBXSR2CA2CU3O10-Y GLASS SYSTEMS - OPTICAL POLARIZED-LIGHT MICROSCOPY, ELECTRICAL AND MAGNETIC-PROPERTIES
Cloots, Rudi ULg; Romain, Anne-Claude ULg; Rulmont, André ULg et al

in Superconductor Science & Technology (1993), 6(12), 850-857

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C ... [more ▼]

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C for 96 or 144 h (with one intermediary grinding). High-resolution polarization micrographs and electrical (and magnetic susceptibility) measurements have been taken. Various growth mechanisms can thus be checked, and the physical properties are studied in relation to the microstructure. It is found that the 2223 phase does not crystallize directly from the amorphous one but results from a dissolution-reprecipitation process. The stability of the 2212 phase is emphasized. The 2201 phase precipitates at high temperature and rapidly reacts with the melt to form the 2223 phase. The kinetics of the lead-substituted sample seems to be controlled by the Ca2PbO4 phase. which acts as a flux. [less ▲]

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See detailSex differences in fear reactions in sheep
Vandenheede, Marc ULg; Bouissou, M. F.

in Applied Animal Behaviour Science (1993), 37

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See detailCarbohydrate-deficient glycoprotein syndrome type II.
Jaeken, J.; De Cock, P.; Stibler, H. et al

in Journal of inherited metabolic disease (1993), 16(6), 1041

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See detailEndogenous substrate oxidation during exercise and variations in breath 13CO2/12CO2.
Gautier, J. F.; Pirnay, Freddy ULg; Jandrain, Bernard ULg et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1993), 74(1), 133-8

This study attempted to induce a major shift in the utilization of endogenous substrates during exercise in men by the use of a potent inhibitor of adipose tissue lipolysis, Acipimox, and to see to what ... [more ▼]

This study attempted to induce a major shift in the utilization of endogenous substrates during exercise in men by the use of a potent inhibitor of adipose tissue lipolysis, Acipimox, and to see to what extent this affects the 13C/12C ratio in expired air CO2. Six healthy volunteers exercised for 3 h on a treadmill at approximately 45% of their maximum O2 uptake, 75 min after having ingested either a placebo or 250 mg Acipimox. The rise in plasma free fatty acids and glycerol was almost totally prevented by Acipimox, and no significant rise in the utilization of lipids, evaluated by indirect calorimetry, was observed. Total carbohydrate oxidation averaged 128 +/- 17 (placebo) and 182 +/- 21 g/3 h (Acipimox). Conversely, total lipid oxidation was 84 +/- 5 (placebo) and 57 +/- 6 g/3 h (Acipimox; P < 0.01). Under placebo, changes in expired air CO2 delta 13C were minimal, with only a 0.49/1000 significant rise at 30 min. In contrast, under Acipimox, the rise in expired air CO2 delta 13C averaged 1/1000 and was significant throughout the 3-h exercise bout; in these conditions calculation of a "pseudooxidation" of an exogenous sugar naturally or artificially enriched in 13C, but not ingested, would have given an erroneous value of 19.8 +/- 2.6 g/3 h. Thus under conditions of extreme changes in endogenous substrate utilization, an appropriate control experiment is mandatory when studying exogenous substrate oxidation by 13C-labeled substrates and isotope-ratio mass spectrometry measurements on expired air CO2. [less ▲]

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See detailChanges In The Hypophyseal-Gonadal Axis During The Onset Of Puberty In Young Bulls
Renaville, Robert ULg; Devolder, A.; Massart, Serge et al

in Journal of Reproduction and Fertility (1993), 99(2),

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See detailPresence Of Growth Hormone-Binding Proteins In Cattle Plasma And Milk
Devolder, A.; Renaville, Robert ULg; Sneyers, M. et al

in Journal of Endocrinology (1993), 138(1),

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See detailRéussite de quatre nichées successives chez le martin pêcheur d'Europe (Alcedo atthis) au cours de la même saison
Libois, Roland ULg

in Aves (1993), 30(1), 31-36

From 1985 to 1992, 229 breeding pairs of kingfisher were studied to determine the reproduction success and the way population recovered after the severe winter 1984-85. From these investigations, we were ... [more ▼]

From 1985 to 1992, 229 breeding pairs of kingfisher were studied to determine the reproduction success and the way population recovered after the severe winter 1984-85. From these investigations, we were able to observe four successive nesting attempts by five different pairs. Four broods were raised by one of the pairs. As the adult were ringed birds and were regularky checked throughout the breeding season, ther can be no doubt, now, as to the possibility of a fourth brood for this species, at least in peculiar circumstances. [less ▲]

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See detailPiaget et la pédagogie : une confrontation difficile, mais prometteuse
Crahay, Marcel ULg

in Apprendizagem/Disenvolvimento (1993), III(13/14),

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See detailEffects on performance and meat characteristics of a diet supplemented with fat during the finishing period of growing fattening bulls
Hollo, Véronique; Marche, Christian; Dufrasne, Isabelle ULg et al

in Animal Production (1993), 56

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See detailAnalyse morphométrique des poudres : Une approche systématique et robuste par la Morphologie Mathématique
Pirard, Eric ULg

in Revue de Métallurgie - Sciences et Génie des Matériaux (1993), 9

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See detailTemporal reasoning and reasoning theories : a case study in anaesthesiology
Sougné, Jacques ULg; Nyssen, Anne-Sophie ULg; De Keyser, Véronique ULg

in Psychologica Belgica (1993), 33(2), 311-328

The purpose of this article is to clarify the theoritical base necessary for the design of a computer-based simulation of temporal reasoning. Simulation allows a better understanding of phenomena that ... [more ▼]

The purpose of this article is to clarify the theoritical base necessary for the design of a computer-based simulation of temporal reasoning. Simulation allows a better understanding of phenomena that appear in working situations and even, understanding and preventing some human errors. In order ot illustrate theoritical concepts, we will provide examples of a situation in which the dynamic character of the evolution, the critical character of the planning and of the synchronization force temporal reasoning. This situation will be that of anaesthesia. [less ▲]

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See detailScaled effective chiral lagrangians for the propagation of scalar and vector mesons in dense matter
Jaminon, Martine ULg; Ripka, Georges

in Nuclear Physics A (1993), 564

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See detailIdentification of eae genes in rabbit attaching and effacing enteropathogenic Escherichia coli (EPEC)
Pohl, P.; Peeters, J. E.; Jacquemin, E. R. et al

in Infection and Immunity (1993), 61

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See detailEssential oil production by Anthemis nobilis L. tissue culture.
Fauconnier, Marie-Laure ULg; Jaziri, M.; Marlier, Michel et al

in Journal of Plant Physiology (1993), 141(6), 759-761

The production of essential oil by tissue culture s ol Antbemis nobilis L. including cell suspension, shoot and crown-gall cultures is reported. The biosynthetic capability of these different cultures was ... [more ▼]

The production of essential oil by tissue culture s ol Antbemis nobilis L. including cell suspension, shoot and crown-gall cultures is reported. The biosynthetic capability of these different cultures was compared with that of plants grown in a field. The addition of crude polysaccharide fraction prepared from yeast extract and from the plant itself to shoot cultures affected the composition and total essential content (from 0.08 o/o to 0.3Qo/o dry weight). The essential oil content of the crown-gall tissue ol A. nobilis was 0.25 % of the dry weight and the composition of the essential oil was comparable to that of the flowers. [less ▲]

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See detailEfficient lipofection of human trophoblast cells in primary cultures
Jacquemin, P.; Alsat, E.; Oury, Cécile ULg et al

in Biochemical and Biophysical Research Communications (1993), 196(1), 376-81

Human choriosomatomammotropic hormone, also known as placental lactogen, is expressed in syncytiotrophoblast cells of the placenta. Studying transcriptional regulation of the genes coding for this hormone ... [more ▼]

Human choriosomatomammotropic hormone, also known as placental lactogen, is expressed in syncytiotrophoblast cells of the placenta. Studying transcriptional regulation of the genes coding for this hormone, we became interested in transfecting primary cultures of these trophoblast cells. In this study, we show that it is possible to transfect, by the lipofection method, these giant cells in an efficient and reproducible manner. We show the presence of an enhancer region downstream from the hCS-B gene, functionally active in these cells; furthermore, we demonstrate the placenta-specific characteristic of this enhancer, previously identified in a human choriocarcinoma cell line. [less ▲]

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See detailLes méthodes d'analyse factorielle : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1993), 1

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements ... [more ▼]

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements useful when interpreting the results of an analysis and the methods are illustrated by completely worked out examples. [less ▲]

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See detailCharacterization of the negative regulatory protein PHO80 involved in transcriptional regulation of PHO5 in Saccharomyces cerevisiae
Jacqmin, S.; Gilliquet, V.; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1993), 101

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See detailHEXAGONAL MARANGONI CONVECTION IN A RECTANGULAR BOX WITH SLIPPERY WALLS
Dauby, Pierre ULg; Lebon, Georgy ULg; COLINET, P. et al

in Quarterly Journal Of Mechanics And Applied Mathematics (1993), 46(Part 4), 683-707

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See detailNeutrophilic Eccrine Hidradenitis. A Case Report
Nikkels, Arjen ULg; Hansen, Isabelle ULg; Collignon, Jacques ULg et al

in Acta Clinica Belgica (1993), 48(6), 397-400

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old ... [more ▼]

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old woman with acute myeloblastic leukemia under daunorubicin, cytarabine and etoposide chemotherapy. She developed red, tender and painful nodules on a shoulder. The lesions resolved spontaneously. Histological examination is mandatory as the clinical presentation of this dermatosis is highly polymorphic. Leukemia cutis, sepsis, deep fungal infection and Sweet's syndrome must be excluded as these implicate different therapies. [less ▲]

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See detailOnce daily administration of amikacin. Adaptation to neonatology for infants less than 3 days of postnatal age
Battisti, Oreste ULg

in Médecine et Maladies Infectieuses (1993), 23

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See detailFollicular Dendritic Cells Do Not Produce Tnf-Alpha nor its Receptor
Mancini, I.; Bosseloir, A.; Hooghe-Peters, E. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailIdentification of elemental sulphur (S8) in Boscia senegalensis (Pers.) Lam ex Poir. leaves.
Lognay, Georges ULg; Seck, D.; Marlier, M. et al

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(4),

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See detailUne logique de l'anorexie mentale
Servais, Véronique ULg

in Revue Internationale de Systémique (1993), 7(4), 385-418

The paper presents a batesonian approach of anorexia nervosa. The illness is viewed as a positive feedback loop. The first restrictions appear as a solution to diverse problems of adolescence. Then the ... [more ▼]

The paper presents a batesonian approach of anorexia nervosa. The illness is viewed as a positive feedback loop. The first restrictions appear as a solution to diverse problems of adolescence. Then the restrictions become a deutero-learning : the girl finds pleasure and security in restriction behaviours. She si permanently looking for challenging contexts where she can proof her self control. Because the control is a deutero-learning the behavior cannot be diminished through punishment. Only the restoration of relationships with the whole personnality and the environment can give the girl the therapeutic experience of becoming to as system that she cannot control. [less ▲]

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See detailVers une optimalisation de la formation langagière de futurs cadres: une expérience en semi-autonomie à la K.U.Leuven
Sanctobin, V.; Slootmaekers, A.; Vanden Berghe, Kristine ULg et al

in Association Belge de Linguistique Appliquée Papers (1993), 15

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See detailMeasurement of the 2s2p2(4P)3s 3P2 lifetime in N II by beam-foil-laser spectroscopy
Bastin, Thierry ULg; Baudinet-Robinet, Y.; Garnir, Henri-Pierre ULg et al

in Journal Physical II (1993), 3

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the ... [more ▼]

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the beam-foil lifetime values reported previously for the 3s' 3P term. No theoretical value for the lifetime of this term is available at the present time. [less ▲]

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See detailThe 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis
Clapp, Carmen; Martial, Joseph ULg; Guzman, Raphaël C et al

in Endocrinology (1993), 133(3), 1292-9

The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable ... [more ▼]

The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable therapeutic potential in the treatment of cancer. We previously reported that the 16-kilodalton N-terminal fragment of rat PRL (16K rPRL) was a potent inhibitor of capillary endothelial cell proliferation via a novel receptor. We now report that the nanomolar concentrations of recombinant human 16K PRL inhibit basal and basic fibroblast growth factor- or vascular endothelial growth factor-stimulated growth of bovine brain capillary endothelial cells. 16K human (h) PRL also inhibits stimulation of human umbilical vein endothelial cell proliferation by basic fibroblast growth factor. The organization of endothelial cells into capillary-like structures in type I collagen gels is also prevented by 16K hPRL. Furthermore, in an in vivo assay, the chick embryo chorioallantoic membrane assay, 16K hPRL as well as 16K rPRL were potent inhibitors of capillary formation. 16K hPRL, like 16K rPRL, maintains its biological activity as a partial PRL agonist at PRL receptors on mammary gland epithelial cells. These data demonstrate for the first time that the biological activity of 16K rPRL is not unique and that similar fragments of hPRL are active. The antiangiogenic activity of these molecules is conserved across avian and mammalian species. That 16K hPRL is a potent antiangiogenic factor in in vitro and an in vivo assay raises the exciting potential of this peptide being capable of inhibiting tumor growth. [less ▲]

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See detailVisualizing the evolution of a star on a graphic workstation
Noels-Grötsch, Arlette ULg; Papy, Roland; Remy, F.

in Computers in Physics (1993), 7(2), 202-207

Theoretical models of a one solar mass star from the gravitational contraction onto the main sequence of the Hertzsprung-Russell diagram are visualized on a Tektronix 4337 workstation.

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See detailAnalgesic Efficiency of Propacetamol Hydrochlorid after Lumbar Disc Surgery
Hans, Pol ULg; Brichant, Jean-François ULg; Bonhomme, Vincent ULg et al

in Acta Anaesthesiologica Belgica (1993), 44(4), 129-33

The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients ... [more ▼]

The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients scheduled for lumbar disc surgery were randomly allocated to two groups. They were given either propacetamol 2 g or saline every 6 hours, starting at the end of procedure for a 24 hours period. The pain intensity (VAS) was not significantly different between the two groups except 3 and 4 hours after surgery, where it was higher in the paracetamol group. The cumulative narcotic consumption (piritramide on request) was higher in the placebo group from 6 hours till 9 hours after surgery but not significantly different after 24 hours. Piritramide administration decreased VAS score significantly in both groups while propacetamol reduced it in a significant way only when given from 12 hours after surgery. [less ▲]

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See detailLaparoscopy, urology, and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailPhysiologie de la cellule enterochromaffin-like (ECL) dans la régulation de la sécrétion gastrique acide
Delwaide, Jean ULg; Belaiche, Jacques ULg; Latour, Pascale ULg

in Médecine & Chirurgie Digestives (1993), 22

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir ... [more ▼]

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir quelle était la cellule fundique qui produisait de l'histamine dans les conditions physiologiques. Deux cellules seront envisagées, les mastocytes et les cellules ECL qui sont des cellules endocrines exclusivement localisées dans le fundus. Quelques arguments seront développés, dont ceux provenant de notre expérience, permettant de penser que la cellule ECL contient de l'histamine. L'article se terminera par un essai d'intégration de la cellule ECL dans le schéma de la sécrétion gastrique acide en montrant son rôle essentiel potentiel. [less ▲]

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See detailHomologous recombinant growth hormone and calcium metabolism in the tilapia oreochromis mossambicus, adapted to freshwater
Flik, G.; Atsma, W.; Fenwick, J. C. et al

in Journal of Experimental Biology (1993)

Homologous recombinant tilapia growth hormoe was tested for its effect on calcium metabolism in freshwater tilapia Oreochromis mossambicus. A comparison of the role of GH and prolactin in calcium ... [more ▼]

Homologous recombinant tilapia growth hormoe was tested for its effect on calcium metabolism in freshwater tilapia Oreochromis mossambicus. A comparison of the role of GH and prolactin in calcium regulation of the tilapia led to the conclusion that GH has specific calciopropic effects on freshwater Tilapia that differ from those of prolactin. [less ▲]

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See detailEtude comparative des formules d'interaction poutre-poteau
Jaspart, Jean-Pierre ULg; Briquet, C.; Maquoi, René ULg

in Construction Métallique (1993), n°4

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See detailFollicular dendritic cells: isolation procedures, short and long term cultures.
Heinen, Ernst ULg; Tsunoda, R.; Marcoty, C. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailL'immersion : une autre façon d'apprendre une langue étrangère
Blondin, Christiane ULg

in Recherche en Education. Théorie & Pratique (1993), 14

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See detailLes chimpanzés : un modèle animal de la relation clientélaire
Servais, Véronique ULg

in Terrain (1993), 21(octobre), 67-80

The paper is about the dominance and coalition relationship among male chimpanzees. It focuses on the dependance relationship between the members of the coalition and distinguishes stable and unstable ... [more ▼]

The paper is about the dominance and coalition relationship among male chimpanzees. It focuses on the dependance relationship between the members of the coalition and distinguishes stable and unstable coalitions. A coalition is unstable if the support of the dominated individual is conditional and stable if it is not (i.e. among two brothers). In an unstable coalition the dominated indivuual can afford some priviledge, the dominant is very dependent on the subordinate and the relationship with the dominant is tense. Analogies with human power relationships are suggested. [less ▲]

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See detailUltrastructural distribution of DNA within the nucleolus of various animal cell lines or tissues revealed by terminal deoxynucleotidyl transferase.
Thiry, Marc ULg; Ploton, D.; Menager, M. et al

in Cell & Tissue Research (1993), 271(1), 33-45

We have used the highly sensitive in situ terminal deoxynucleotidyl transferase method, applied to ultrathin sections, to investigate the location of DNA within nucleoli of various animal cells. In all ... [more ▼]

We have used the highly sensitive in situ terminal deoxynucleotidyl transferase method, applied to ultrathin sections, to investigate the location of DNA within nucleoli of various animal cells. In all the nucleoli studied, intense labelling is revealed over the peri- and intranucleolar condensed chromatin. Gold particles are also consistently found over the fibrillar centres, especially at their periphery, namely in the border area between the fibrillar centres and the dense fibrillar component, whereas the dense fibrillar component itself seems to be free of label in nucleoli in which these two compartments can be distinguished. We conclude that, in transcriptionally active nucleoli of this type, DNA is a characteristic constituent of the fibrillar centres, distinguishing them functionally from the dense fibrillar component. Some nucleoli exhibit neither fibrillar centres nor a dense fibrillar component, but have a single, albeit heterogeneous accumulation of fibrillar material; gold particles are consistently seen over some parts of this fibrillar compartment. This suggests that certain parts of the fibrillar material are functionally similar to the fibrillar centres of those nucleoli that possess them. [less ▲]

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See detailStructure, function and assembly of the nucleolus.
Scheer, U.; Thiry, Marc ULg; Goessens, Guy ULg

in Trends in Cell Biology (1993), 3(7), 236-41

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins ... [more ▼]

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis. [less ▲]

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See detailCalcitonins: Newer Routes of Delivery
Reginster, Jean-Yves ULg

in Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis & the National Osteoporosis Foundation of the USA (1993), 3(Suppl 2), 3-7

Because of its anti-osteoclastic and analgesic properties, calcitonin is a first-line choice in the treatment of several bone diseases characterized by absolute or relative bone resorption. With regard to ... [more ▼]

Because of its anti-osteoclastic and analgesic properties, calcitonin is a first-line choice in the treatment of several bone diseases characterized by absolute or relative bone resorption. With regard to the prevention and treatment of postmenopausal osteoporosis, the chronic nature of the disease and the subsequent long duration of the pharmacological intervention require uncomfortable parenteral administration to be repeated on a long-term basis. Newer routes of administration have therefore been developed. At present the most promising of these are the nasal spray and the rectal suppository. Both routes have been shown to induce significant increases in plasma levels of salmon calcitonin. The ability of salmon calcitonin to cross the nasal mucosa was shown immunologically by the generation of specific anti-salmon-calcitonin antibodies in the plasma. In healthy volunteers these alternative routes of administration do not decrease the anti-osteoclastic activity of calcitonin, as demonstrated by a significant decrease in biochemical parameters that reflect bone turnover. In the prevention and treatment of postmenopausal osteoporosis, as well as in the treatment of Paget's disease of bone, the properties of calcitonins are generally preserved if they are administered non-parenterally. However, the equivalent doses required to sustain the effects of calcitonin have not been fully elucidated. This article reviews the potential benefits of two methods of non-parenteral administration of calcitonins in the prevention and treatment of postmenopausal osteoporosis. [less ▲]

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See detailDetection of ribosomal RNA during the cell cycle in Ehrlich tumour cells by electron microscope in situ hybridization.
Thiry, Marc ULg

in European Journal of Morphology (1993), 31(1-2), 13-6

The fine spatial distribution of rRNA within Ehrlich tumour cells has been investigated during the cell cycle by in situ hybridization with a biotinylated probe. In interphase cells, rRNA was essentially ... [more ▼]

The fine spatial distribution of rRNA within Ehrlich tumour cells has been investigated during the cell cycle by in situ hybridization with a biotinylated probe. In interphase cells, rRNA was essentially detected in the ribosome-rich cytoplasmic regions and in the three main nucleolar components. In mitotic cells, besides the presence, as expected, of rRNA in the ribosome-rich spaces, evident label was observed over material situated around and between the chromosomes during anaphase and telophase as well as over the reforming nucleoli during telophase. [less ▲]

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See detailBiometrical evaluation of the stratum corneum texture in patients under maintenane hemodialysis
Deleixhe-Mauhin, F.; Pierard, Claudine ULg; Krzesinski, Jean-Marie ULg et al

in Nephron (1993), 64

Xerosis and hydration of the stratum corneum were evaluated in 60 hemodialyzed patients. Xerosis and a low capacitance of the stratum corneum were evidenced in more than 80% of the patients. Pruritus was ... [more ▼]

Xerosis and hydration of the stratum corneum were evaluated in 60 hemodialyzed patients. Xerosis and a low capacitance of the stratum corneum were evidenced in more than 80% of the patients. Pruritus was present in two third of the subjects. We failed to disclose any significant relationship between severity of these three parameters. [less ▲]

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See detailUltrastructural distribution of DNA and RNA within the nucleolus of human Sertoli cells as seen by molecular immunocytochemistry.
Thiry, Marc ULg

in Journal of Cell Science (1993), 105 ( Pt 1)

The precise distribution of DNA and RNA within the human Sertoli cell nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. In Sertoli ... [more ▼]

The precise distribution of DNA and RNA within the human Sertoli cell nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. In Sertoli cells, the nucleolar components show a typical spatial distribution. The fibrillar centres are not surrounded by a layer of dense fibrillar component, but come in contact only with strands of dense fibrillar component. These fibrillar parts of strands are the extensions of granular strands connected to a large granular mass. These strands delimit numerous nucleolar interstices in which chromatin fibres are clearly obvious. Using the in situ terminal deoxynucleotidyl transferase/immunogold procedure for detecting DNA, we find evident label exclusively over the chromatin fibres enclosed in the nucleolar interstices and over the fibrillar centres, and no significant label over the dense fibrillar component and granular component of the nucleolus. Furthermore, using the polyadenylate nucleotidyl transferase/immunogold procedure for detecting RNA, we show that label is deposited not only over the granular component and dense fibrillar component, as expected, but also quite obviously over the fibrillar centres. No label is seen over the interstices containing chromatin. [less ▲]

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See detailConnection and frames design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Rakennustekniikka = Finnish Civil Engineering Journal (1993), 3/93

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See detailBiphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice
Tirelli, Ezio ULg; Terry, P.

in Psychopharmacology (1993), 110(1-2), 69-75

Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously ... [more ▼]

Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously) locomotor stimulation. The time-course effect was biphasic at very high doses (100-300 mg/kg), with dose-related locomotor depression followed by dose-related long-term hyperlocomotion. For all doses, locomotor effects were detectable throughout the 4-hr test period. To determine whether these effects were mediated by D-sub-1 receptor stimulation, effects of SKF 38393 were assessed in combination with behaviorally inactive and active doses (0.1 and 0.2 mg/kg, respectively) of the selective D-sub-1 receptor antagonist SCH 39166. Both doses of SCH 39166 attenuated the hyperlocomotion induced by 30 mg/kg of the agonist to a similar degree. However, neither dose was able to reverse either the depressant or the stimulatory effects of 300 mg/kg SKF 38393. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in New Steel Construction (1993), 1(N°6), 30-33

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See detailAssociation of Aortic Stenosis and Gastrointestinal Bleeding (Heyde's Syndrome). Report of Two Cases
Natowitz, L.; DEFRAIGNE, Jean ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1993), 93(1), 31-3

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent ... [more ▼]

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent small intestinal bleeding originating from angiodysplasia stopped after aortic valve replacement. We report two cases of patients presenting with a recurrent small intestinal bleeding originating from digestive angiodysplasia and suffering from aortic stenosis. Diagnosis of both pathologies is well documented in both cases. The replacement of the aortic valve by a biologic prosthesis stopped the bleeding. Prior to aortic valve replacement, the two patients suffered severe recurrent blood loss from intestinal angiodysplasia. The treatment of aortic stenosis greatly favored both cardiac and general status. We recommend aortic valve replacement with a biologic prosthesis prior to intestinal resection in patients presenting with Heyde's syndrome. We stress on the fact that anticoagulants must be stopped in order to minimize the risk of further bleeding. [less ▲]

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See detailProduction of active oxygen species by isolated human chondrocytes.
Henrotin, Yves ULg; Deby-Dupont, G.; DEBY, C. et al

in British Journal of Rheumatology (1993), 32(7), 562-7

The ability of isolated human chondrocytes to produce active oxygen species has been investigated. The two methods for determining H2O2 and hydroxyl radicals (.OH) production were, by a fluorimetric ... [more ▼]

The ability of isolated human chondrocytes to produce active oxygen species has been investigated. The two methods for determining H2O2 and hydroxyl radicals (.OH) production were, by a fluorimetric method (production of dichlorofluorescein from a precursor in the presence of horseradish peroxidase and H2O2) and by a chromatographic method (measurement of ethylene production from gamma-methiol-keto-butyric acid after .OH attack). Chondrocytes were tested, both with and without activation by phorbol myristate acetate (PMA: 10(-6) M), in the presence of Ca2+ (1 x 10(-4) M) and Mg2+ (2 x 10(-4) M) or after variable periods of anoxia under nitrogen (4 to 12 h) followed by reoxygenation (with 95% O2, 5% CO2). Under these experimental conditions, the PMA-excited chondrocytes produced from 80 to 180 nmol of hydrogen peroxide per 1 x 10(6) cells and chondrocytes subjected to anoxia-reoxygenation produced up to 1700 nmol H2O2 per 1 x 10(6) cells. The hydroxyl radical production by PMA or anoxia-reoxygenation excited cells reached 600% of the production of non-excited cells and 1300% when they were subjected to successive stimulations by PMA and anoxia-reoxygenation. The possible pathological significance of these observations is discussed. The results indicate that stimulated human chondrocytes are capable of producing active oxygen species which could play a major role in joint inflammation and cartilage damage. [less ▲]

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See detailExemples d'utilisation de la Carte des Sols de Belgique comme base d'un systeme d'information geographique pour la gestion des terroirs.
Engels, Patrick ULg; Bock, Laurent ULg; Neven, Cécile et al

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(2-3),

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See detailAnti-Ia treatment prevents lupus-like autoimmune syndrome in mice neonatally tolerized to alloantigens.
Kramar, G.; Schurmans, Stéphane ULg; Aguado, T. et al

in Journal of Autoimmunity (1993), 1

Neonatal injection of semi-allogeneic F1 spleen cells into newborn parental mice results in induction of tolerance to the corresponding class I alloantigen and chimerism. This state of tolerance is ... [more ▼]

Neonatal injection of semi-allogeneic F1 spleen cells into newborn parental mice results in induction of tolerance to the corresponding class I alloantigen and chimerism. This state of tolerance is associated with the development of a transient lupus-like autoimmune syndrome. Previous experiments performed in our laboratories have shown that host CD4+ T lymphocytes and donor B cells persist in the host and are essential in triggering the autoimmune syndrome observed in neonatally tolerized mice. In this study, we show that early treatment of tolerized mice with anti-donor MHC class II mAb totally prevents the lupus-like syndrome. Moreover, delayed treatment significantly decreases, but to a lesser extent, autoimmune pathological features in tolerized mice. Taken together, these results show that lupus-like autoimmune syndrome developed by neonatally tolerized mice is efficiently prevented by anti-Ia treatment without interfering with the induction of tolerance [less ▲]

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See detailMeasurement of Total Respiratory Impedance in Dogs by the Forced Oscillation Technique
Clercx, Cécile ULg; Gustin, Pascal ULg; Landser, F. J. et al

in Veterinary Research Communications (1993), 17(3), 227-239

The resistance (Rrs) and reactance (Xrs) of the total respiratory system were determined at various frequencies in 14 healthy conscious beagle dogs. A pseudorandom noise pressure wave was produced at the ... [more ▼]

The resistance (Rrs) and reactance (Xrs) of the total respiratory system were determined at various frequencies in 14 healthy conscious beagle dogs. A pseudorandom noise pressure wave was produced at the nostrils of the animals by means of a loudspeaker adapted to the nose by a tightly fitting mask. A Fourier analysis of the pressure and flow signals yielded mean Rrs and Xrs, over 16 s, at frequencies from 2 to 26 Hz. The influence of the posture of the dog, the position of its head, the linearity of the respiratory system, the reproducibility of the method and the effects of upper and lower airway obstructions were studied. In sitting and standing healthy dogs with the head in the extended position, Rrs values increased progressively with frequency from 5.4 +/- 0.4 (SEM) cmH2O L-1s at 6 Hz up to 8.8 +/- 0.7 cmH2O L-1s at 26 Hz, the mean resonant frequency being 6.1 +/- 0.5 Hz. No significant differences were observed between measurements performed with the head in the normal or the extended position. In a recumbent posture, all Rrs values were increased but Rrs was still dependent on the frequency in the same way (7.1 +/- 0.7 cmH2O L-1s at 6Hz up to 10.0 +/- 0.5 cmH2O L-1s at 26 Hz). Tracheal compression also induced higher Rrs values without changes in the frequency dependence or in the resonant frequency. In anaesthetized dogs, airway obstruction was induced by inhalation of histamine (4 mg/ml for 5 min; the Rrs values tended to decrease with increasing frequency, and the resonant frequency was markedly increased [less ▲]

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See detailEvolution de la situation des mammifères sauvages en Région wallonne au cours de décennie 1983-1992
Libois, Roland ULg

in Cahiers d'Ethologie (1993), 13(1), 77-92

During the last ten years, the evolution of the status of the mammal fauna of Wallony (southern part of Belgium) can be characterized by four main trends: i- enforcement of a better legal protection ii ... [more ▼]

During the last ten years, the evolution of the status of the mammal fauna of Wallony (southern part of Belgium) can be characterized by four main trends: i- enforcement of a better legal protection ii- arrival of at least four new species: coypu, raccoon, raccon-dog and American mink iii- restoration of badger numbers following the efficient control of rabies iv- increase of anthropophilic or game species (stone marten, ungulates). Unfortunately, the most threathened species (otter, horseshoe bats, barbastella) did not recover. [less ▲]

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See detailModifications of the extracellular matrix of aneurysmal abdominal aortas as a function of their size.
SAKALIHASAN, Natzi ULg; HEYERES, Antoine ULg; Richelle, Betty ULg et al

in European Journal of Vascular Surgery (1993), 7(6), 633-7

Collagen and elastin are the main extracellular matrix proteins providing the aortic wall with adequate mechanical properties and resistance for proper function. Our study aimed at investigating the ... [more ▼]

Collagen and elastin are the main extracellular matrix proteins providing the aortic wall with adequate mechanical properties and resistance for proper function. Our study aimed at investigating the relationship between the elastin concentration of the wall of normal and aneurysmal abdominal aortas (AAA), the collagen concentration, and its extractability, as a function of their size. Infrarenal aortas were collected from 30 patients undergoing operative repair of abdominal aortic aneurysm. Age-matched control samples were obtained from eight autopsies of individuals without vascular disease. Samples were divided into five groups according to the aortic diameter: control group (group N, n = 8); < 50 mm (group I, n = 6; between 50-75 mm (group II, n = 10); > 75 mm (group III, n = 7); and ruptured (group IV, n = 7). The collagen concentration in samples from group I was similar to the controls. An increased collagen concentration was observed in group II and remained at the same level in the largest and ruptured aneurysms. Extractability of collagen was found to be increased in group III and was even higher in group IV. A highly significant reduction in elastin concentration was observed in group I and there was progressive reduction with increasing diameter and rupture. A significant correlation could be established between aortic diameter, increased collagen extractability and decreased elastin content. [less ▲]

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See detailCreativity in Non-Literary Translation
Pagnoulle, Christine ULg

in Perspectives : Studies in Translatology (1993), (1), 79-90

Three short non literary texts illustrate the need for translators' actively stepping in. Since the author is both a translator and a teacher of translation didactic conclusions are also drawn.

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See detailLa place de la musique en hôpital de jour
Triffaux, Jean-Marc ULg; Bertrand, Jean ULg

in Psychologie Médicale (1993)

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See detailEvidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
Geenen, Vincent ULg; Achour, Imane; Robert, Françoise et al

in Thymus (1993), 21(2), 115-127

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human ... [more ▼]

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human thymic insulin-related self antigen able to represent the pancreatic islet ß cell function in face of the developing T cells. Immunofluorescence studies were performed on human and rat thymic sections, as wess as on the rat IT-45R1 thymic epithelial cell line using several antibodies to epitopes of the insulin peptide family. These studies identify beyond any doubt that IGF2 is the dominant thymic peptide of the insulin family. The sequence of an insulin-derived autoantigen is proposed. This autoantigen is a nonamer and has a hydrophobic residue leucine at position 9. In human species, this autoantigen would primarily be tolerogenic for the pancreatic ß-cell endocrine function during fetal development. [less ▲]

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See detailTHE CERTIFIED TOTAL GLUCOSINOLATE CONTENT IN 3 RAPESEEDS (CRM-190, CRM-366 AND CRM-367)
Wathelet, Jean-Paul ULg; WAGSTAFFE, P. J.; BOENKE, A. et al

in Fresenius' Journal of Analytical Chemistry (1993), 347(10-11), 396-399

The preparation of certified rapeseed reference materials and the steps taken to establish the certified values for total glucosinolate contents are described. Details are given of the studies to ... [more ▼]

The preparation of certified rapeseed reference materials and the steps taken to establish the certified values for total glucosinolate contents are described. Details are given of the studies to demonstrate the homogeneity and stability of the material. The results of the certification exercise for total glucosinolate content, which involved European laboratories who applied a variety of methods (high-pressure liquid chromatography, gas liquid chromatography, determination of enzymatically released glucose and sulphate), are presented and discussed. The certified values for the glucosinolate content (mumol/g of non-defatted whole seeds) and the 95% confidence level are the following: CRM 366 (12.1 +/- 0.8 mumol/g), CRM 190 (25.5 +/- 0.9 mumol/g) and CRM 367 (102.4 +/- 3 mumol/g) (CRM = certified reference material). Indicative values (not certified) for individual glucosinolates are also given. Certified sulphur values (mg/g of non defatted whole seeds) have been determined by other laboratories: CRM 366 (3.41 +/- 0.12 mg/g), CRM 190 (4.93 +/- 0.15 mg/g) and CRM 367 (10.5 +/- 0.40 mg/g). [less ▲]

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See detailNucleotide sequence of the bovine viral diarrhoea virus Osloss strain: comparison with related viruses and identification of specific DNA probes in the 5' untranslated region
De Moerlooze, L.; Lecomte, C.; Brown-Shimmer, S. et al

in Journal of General Virology (The) (1993), 74

The nucleotide sequence of the cytopathic Osloss isolate of bovine viral diarrhoea virus (BVDV) was deduced from overlapping cDNA clones and from PCR products. The Osloss genome is an RNA molecule of ... [more ▼]

The nucleotide sequence of the cytopathic Osloss isolate of bovine viral diarrhoea virus (BVDV) was deduced from overlapping cDNA clones and from PCR products. The Osloss genome is an RNA molecule of positive polarity containing 12480 nucleotides and having the capacity to code for a polyprotein of 3975 amino acids. The presence of the previously described internal stop codon in this viral sequence was disproved after direct sequencing of the appropriate PCR-amplified fragment. Except for the previously reported insertion of a sequence coding for a ubiquitin-like protein, the viral genome shares great similarity with those of three other strains of the pestivirus genus. Computer-assisted sequence analyses and comparisons of known pestiviral genomic sequences led us to identify selected PCR primers in the 5' untranslated region. These primers were used successfully to amplify 18 distinct pestivirus isolates and potential DNA probes were noted from the deduced sequences. The possible use of a well conserved 26 base fragment as a diagnostic probe was confirmed in hybridization experiments. The 5' untranslated region was further studied and compared with those of other members of the Flaviviridae family, which includes the flaviviruses and the hepatitis C virus group. These sequence analyses support the possibility of discrimination amongst the closely related ruminant pestiviruses, border disease virus and BVDV. [less ▲]

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