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See detailEtude écosystémique d'une gravière de l'ancien lit majeur du Rhin (Krafft-Erstein, Bas-Rhin, France)
Klein, J. P.; Vanderpoorten, Alain ULg

in Martinia (1999), 15(1), 3-13

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See detailCytokinin modulates catalase activity and coumarin accumulation in in vitro cultures of tobacco
Petit-Paly, Geneviève; Franck, Thierry ULg; Brisson, Louise et al

in Journal of Plant Physiology (1999), 155(1), 9-15

Cytokinins (CKs) represent an important class of phytohormones particularly known for their antisenescence properties that might be regulated through an effect on the oxidative metabolism. In the present ... [more ▼]

Cytokinins (CKs) represent an important class of phytohormones particularly known for their antisenescence properties that might be regulated through an effect on the oxidative metabolism. In the present work, we demonstrate the effect of CKs on catalase activity in tobacco cultivated in vitro. The catalase activity observed in suspension-cultured cells decreased slightly during the first hour of CK treatment and increased thereafter to double the level detected in untreated cells. In contrast to these results, catalase activity was inhibited in shoot cultures in which the endogenous levels of CK were elevated by the introduction of the isopentenyltransferase gene or by an exogenous feeding of CK to the cultures. Interestingly, this catalase inhibition correlated with an accumulation of scopolin, an inducible coumarin. Taken together, our results show that CK modulates (directly or undirectly) catalase activity. The inverse relationship that was always found between scopolin accumulation and catalase activity is discussed in terms of vitrification and habituation. [less ▲]

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See detailLa socio-prévention offensive du hooliganisme
Comeron, Manuel ULg; Kellens, Georges ULg

in Revue Sport (1999), 1/2(165-166), 6-11

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See detailSerological and Biochemical Follow-up in Cattle Naturally Infected with Fasciola Hepatica, and Comparison with a Climate Model for Predicting Risks of Fasciolosis
Bossaert, K.; Lonneux, J. F.; Godeau, Jean-Marie ULg et al

in Veterinary Research (1999), 30(6, Nov-Dec), 615-28

Several biological parameters were measured in 31 heifers naturally infected with Fasciola hepatica during one grazing season in the Belgian Ardennes. A forecast model based on daily temperature used to ... [more ▼]

Several biological parameters were measured in 31 heifers naturally infected with Fasciola hepatica during one grazing season in the Belgian Ardennes. A forecast model based on daily temperature used to assess the risk of fasciolosis was fitted to this assay. Cattle were turned out to two pastures. Each pasture was divided into two plots: one was treated with calcium cyanamide and the other was left untreated. The Lymnaea truncatula snails were counted on three different occasions. The results indicated a poor molluscicide efficiency. Body weight gains, anti-Fasciola antibody levels, faecal egg counts, levels of sorbitol dehydrogenase (SDH) and gamma-glutamyl transferase (gamma GT), packed cell volumes, white blood cells and differential leucocyte counts were determined monthly. No statistically significant difference was observed between animals from the two plots regardless of the recorded data. No correlation was found between body weight gains and other biological data. The sampling date had a significant effect on the antibody responses within a same group, and on the enzymatic levels for all groups combined. The forecast results were consistent with the recorded data. Temperature was a major bioclimatic constraint on the transmission of life cycle, and risk of infection occurred mainly in late spring (May/June) and in early September. Current results might be used to issue advice on the need for flukicide treatment of cattle. The indicators of the infection considered alone were useless and it is concluded that herd diagnosis of fasciolosis may rely on the rise of specific antibody levels, possibly associated with an increase in hepatic enzyme activities. [less ▲]

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See detailEstimation of the charge carrier localization length from Gaussian fluctuations in the magneto-thermopower of La0.6Y0.1Ca0.3MnO3
Sergeenkov, S.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in Physical Review. B : Condensed Matter (1999), 60(17), 12322-12328

The magneto-thermoelectric power (TEP) Delta S(T,H) of perovskite-type manganese oxide La0.6Y0.1Ca0.3MnO3 is found to exhibit a sharp peak at some temperature T*=170 K. By approximating the true shape of ... [more ▼]

The magneto-thermoelectric power (TEP) Delta S(T,H) of perovskite-type manganese oxide La0.6Y0.1Ca0.3MnO3 is found to exhibit a sharp peak at some temperature T*=170 K. By approximating the true shape of the measured magneto-TEP in the vicinity of T* by a linear triangle of the form Delta S(T,H) similar or equal to S-p(H)+/-B+/-(H)(T* - T), we observe that B-(H)similar or equal to 2B(+)(H). We adopt the electron localization scenario and introduce a Ginzburg-Landau (GL)-type theory which incorporates the two concurrent phase transitions, viz., the paramagnetic-ferromagnetic transition at the Curie point T-C and the "metal-insulator'' (M-I) transition at T-MI. The latter is characterized by the divergence of the field-dependent charge carrier localization length xi(T,H) at some characteristic field H-o. Calculating the average and fluctuation contributions to the total magnetization and the transport entropy related magneto-TEP Delta S(T,H) within the GL theory, we obtain a simple relationship between T* and the above two critical temperatures (T-C and T-MI). The observed slope ratio B-(H)/B+(H) is found to be governed by the competition between the electron-spin exchange JS and the induced magnetic energy MsHo. The comparison of our data with the model predictions produce T-C = 195 K, JS = 40 meV, M-o = 0.4M(s), and xi(o) = 5 Angstrom for the estimates of the Curie temperature, the exchange coupling constant, the critical magnetization, and the localization length, respectively. The magneto-TEP data obtained by other authors are discussed and Found to be consistent with the model predictions as well. [[S0163-1829(99)00734-1]. [less ▲]

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See detailTEL is a sequence-specific transcriptional repressor.
Lopez, Rodolphe; Carron, Clémence; Oury, Cécile ULg et al

in Journal of Biological Chemistry (1999)

TEL is a gene frequently involved in specific chromosomal translocations in human leukemia and sarcoma that encodes a member of the ETS family of transcriptional regulators. TEL is unusual among other ETS ... [more ▼]

TEL is a gene frequently involved in specific chromosomal translocations in human leukemia and sarcoma that encodes a member of the ETS family of transcriptional regulators. TEL is unusual among other ETS proteins by its ability to self-associate in vivo, a property that is essential to the oncogenic activation of TEL-derived fusion proteins. We show here that TEL is a sequence-specific transcriptional repressor of ETS-binding site-driven transcription of model and natural promoters. [less ▲]

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See detailDroits de passage : une mise au point terminologique
Vanbrabant, Bernard ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (1999)

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See detailEvolution of organic debris and palynomorph preservation in two late middle Frasnian sections, southern Dinant Synclinorium border, Belgium
Vanguestaine, M.; Pardo-Trujillo, A.; Coen-Aubert, M. et al

in Bollettino della Società Paleontologica Italiana (1999), 38(2-3), 317-330

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See detailAirway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling
Legrand, C.; Gilles, Christine ULg; Zahm, J. M. et al

in Journal of Cell Biology (1999), 146(2), 517-29

Cell spreading and migration associated with the expression of the 92-kD gelatinase (matrix metalloproteinase 9 or MMP-9) are important mechanisms involved in the repair of the respiratory epithelium. We ... [more ▼]

Cell spreading and migration associated with the expression of the 92-kD gelatinase (matrix metalloproteinase 9 or MMP-9) are important mechanisms involved in the repair of the respiratory epithelium. We investigated the location of MMP-9 and its potential role in migrating human bronchial epithelial cells (HBEC). In vivo and in vitro, MMP-9 accumulated in migrating HBEC located at the leading edge of a wound and MMP-9 expression paralleled cell migration speed. MMP-9 accumulated through an actin-dependent pathway in the advancing lamellipodia of migrating cells and was subsequently found active in the extracellular matrix (ECM). Lamellipodia became anchored through primordial contacts established with type IV collagen. MMP-9 became amassed behind collagen IV where there were fewer cell-ECM contacts. Both collagen IV and MMP-9 were involved in cell migration because when cell-collagen IV interaction was blocked, cells spread slightly but did not migrate; and when MMP-9 activation was prevented, cells remained fixed on primordial contacts and did not advance at all. These observations suggest that MMP-9 controls the migration of repairing HBEC by remodeling the provisional ECM implicated in primordial contacts. [less ▲]

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See detailDual Harmonic and Time Approaches for the Design of Microwave Devices
Meys, B.; Geuzaine, Christophe ULg; Henrotte, F. et al

in IEEE Transactions on Magnetics (1999), 35(3), 1829--1832

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See detailL’acromégalie et son impact sur la fonction reproductrice
Beckers, Albert ULg; Stevenaert, Achille ULg

in Glunaïkeia (1999), 4(8), 212-218

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See detailNew evaluation therapies for sepsis.
Deby; Damas, Pierre ULg; Lamy, Maurice ULg

in Current Opinion in Anaesthesiology (1999), 12(2), 121-7

This article presents an analysis of the literature of the last 2 years on the treatment of sepsis and septic shock. It appears that most of the antimediator therapies applied in phase II or III clinical ... [more ▼]

This article presents an analysis of the literature of the last 2 years on the treatment of sepsis and septic shock. It appears that most of the antimediator therapies applied in phase II or III clinical trials yielded disappointing results. But, many other therapeutic approaches are proposed or are ongoing, and many papers report critical analysis of the reasons for the lack of success of past clinical trials. [less ▲]

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See detailLe diabete gestationnel: physiopathologie et signification pronostique pour la mere.
Geronooz, I.; Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (1999), 54(5), 434-9

Pregnancy is associated with important changes in mother metabolism, especially in late gestation, among which a decreased glucose tolerance caused by insulin resistance. In some of these women, glucose ... [more ▼]

Pregnancy is associated with important changes in mother metabolism, especially in late gestation, among which a decreased glucose tolerance caused by insulin resistance. In some of these women, glucose intolerance is increased by a defect in B-cell function and diabetes mellitus occurs. These women who develop a gestational diabetes need a close follow-up because they are at high risk for further development of diabetes, especially type 2 diabetes. [less ▲]

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See detailGezelle, mens en onmens
Spinoy, Erik ULg

in Gezelliana. Kroniek van de Gezellestudie (1999)

This article reflects on how the work of the reactionary 19th-century Flemish poet Guido Gezelle can be 'saved' through innovative rereadings.

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See detailDecreased Corticosensitivity in Quiescent Crohn's Disease: An Ex Vivo Study Using Whole Blood Cell Cultures
Franchimont, Denis; Louis, Edouard ULg; Dupont, Pierre et al

in Digestive Diseases & Sciences (1999), 44(6), 1208-15

Corticosensitivity influences the degree and the duration of an inflammatory reaction by altering target cell responses to endogenous and/or exogenous glucocorticoids. Indeed, different clinical responses ... [more ▼]

Corticosensitivity influences the degree and the duration of an inflammatory reaction by altering target cell responses to endogenous and/or exogenous glucocorticoids. Indeed, different clinical responses to glucocorticoids have been observed among patients with Crohn's disease, suggesting different degrees of corticosensitivity in these subjects. The purpose of this study was to compare the corticosensitivity of patients with quiescent Crohn's disease to that of healthy subjects (HS). Nineteen patients with quiescent Crohn's disease and 14 HS were studied; all patients were steroid-free for at least six months; 7 of the 19 were corticosteroid-dependent (CSD) and treated with nonglucocorticoid immunosuppressants at the time of the study. Corticosensitivity was measured by the inhibition of LPS-induced cytokine secretion in whole blood cell cultures treated with increasing concentrations (10(-9) to 10(-6) M) of dexamethasone. Tumor-necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) were measured using specific immunoassays. Crohn's disease patients had a markedly decreased dexamethasone-mediated inhibition of TNF-alpha (P < 0.01), IL-6 (P < 0.001), and IL-1 beta (P < 0.01) compared to healthy subjects, with a shift of the dexamethasone dose-response curve to the right. No significant differences in the basal and LPS-stimulated secretion of the three cytokines were observed between CSD and non-CSD patients, and both subgroups of patients had similar degrees of dexamethasone-mediated cytokine inhibition. We conclude that patients with Crohn's disease have a significant decrease in the corticosensitivity of their leukocytes. This may be related to a specific genetic/constitutional background and/or could be acquired, due to inflammation-related endocrine and/or immune factors. [less ▲]

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See detailTowards Marker Assisted Selection in Livestock
Georges, Michel ULg

in Reproduction Nutrition Development (1999), 39(5-6, Sep-Dec), 555-61

In recent years, genomic tools have become available for most livestock species and are now being used routinely to map quantitative trait loci underlying the genetic variance for numerous economically ... [more ▼]

In recent years, genomic tools have become available for most livestock species and are now being used routinely to map quantitative trait loci underlying the genetic variance for numerous economically important traits. Fine-mapping methods are being devised to refine the initially coarse map positions of the quantitative trait loci to the point required for marker assisted selection and, eventually, the positional cloning of the underlying genes. Mapping information on QTL is beginning to be used to increase genetic response by enhancing genetic variance, selection accuracy, selection intensity and by reducing the generation interval. Optimal use of MAS will require the development of more robust methods for the routine genotyping of preimplantation embryos for multiple markers. [less ▲]

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See detailLimit Cycle Oscillation Control and Suppression
Dimitriadis, Grigorios ULg; Cooper, Jonathan E

in Aeronautical Journal (1999), 103(1023), 257-263

The prediction and characterization of the Limit Cycle Oscillation (LCO) behaviour of nonlinear aeroelastic systems has become of great interest recently. However, much of this work has concentrated on ... [more ▼]

The prediction and characterization of the Limit Cycle Oscillation (LCO) behaviour of nonlinear aeroelastic systems has become of great interest recently. However, much of this work has concentrated on determining the existence of LCOs. This paper concentrates on LCO stability. By considering the energy present in di®erent limit cycles, and also using the Harmonic Balance Method, it is shown how the stability of limit cycles can be determined. The analysis is then extended to show that limit cycles can be controlled, or even suppressed, by the use of suitable excitation signals. A basic control scheme is developed to achieve this, and is demonstrated on a simple simulated nonlinear aeroelastic system. [less ▲]

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See detailThe plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells
Dassonneville, L.; Wattez, N.; Mahieu, C. et al

in Anticancer Research (1999), 19(6B), 5245-5250

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See detailEndogenous auxin and cytokinin levels in shoots of a nonrooting tobacco mutant
Faivre-Rampant, O.; Kevers, Claire ULg; Gaspar, Th

in Bulletin de la Societe Royale des Sciences de Liege (1999), 68(5-6), 318

[No abstract available]

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See detailA reference value for the interior-to-edge ratio of isolated habitats.
Bogaert, Jan ULg; Van Hecke, P; Impens, I

in Acta Biotheoretica (1999), 47(1), 67-77

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See detailMonoclonal Antibodies To Growth Hormone (Gh) Prolong Liver Gh Binding And Gh-Induced Igf-I/Igfbp-3 Synthesis
Beauloye, V.; Muaku, Sm.; Lause, P. et al

in American Journal of Physiology - Endocrinology and Metabolism (1999), 277(2),

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See detailThe ribonucleoside diphosphate reductase inhibitor (E)-2'-Deoxy-(fluoromethylene) cytidine, acts as a cytotoxic radiosensitizer on human cancer cell lines in vitro.
Coucke, Philippe ULg; Decosterd, L-A; Li, Y-X et al

in Cancer Research (1999), 59

ABSTRACT (E)-2*-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier ... [more ▼]

ABSTRACT (E)-2*-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier of radiation response in vitro on a human colon carcinoma cell line (WiDr), and the observed radiosensitization was confirmed on two human cervix cancer cell lines (C33-A and SiHa). Using the clonogenic assay, the effect ratio (ER) at a clinically relevant dose level of 2 Gy was 2.10 (50 nM FMdC), 1.70 (30 nM FMdC), and 1.71 (40 nM FMdC) for the three cell lines WiDr, C33-A, and SiHa, respectively. A more detailed analysis of the importance of timing and concentration of FMdC was done on the WiDr cell line alone, yielding an increased ER(2Gy) with increasing concentration and duration of exposure to the drug, ranging from 1.0 (6 h) to 1.8 (72 h) at 30 nM FMdC and from 1.2 (6 h) to 3.5 (24 h) at 300 nM. We investigated the effect of FMdC on the cellular deoxynucleotide triphosphate pool in WiDr cells and demonstrated a marked depletion of dATP and a significant rise of TTP levels. Cell cycle analysis showed early S-phase accumulation induced by FMdC alone, G2-M block induced by irradiation alone, and an increased accumulation of cells in G2-M if both modalities are used. Our data suggest that FMdC is a radiation response modifier in vitro on different cancer cell lines. The observed radiosensitization may in part be explained by alteration of the deoxynucleotide triphosphate pool, which is consistent with the effect of FMdC on ribonucleoside diphosphate reductase. [less ▲]

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See detailEfectos antitumorales de los agonistas dopaminergicos y de los anàlogos de la somatostatina
Valdes Socin, Hernan Gonzalo ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in Revista Argentina de Endocrinologia y Metabolismo (1999), 36(4), 234-246

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See detailReproducibility of measurements of potential doubling time of tumor cells in the multicenter NCI protocol T92-0045
Wilson, G-D; Paschoud, N; Pavy, J-J et al

in British Journal of Cancer (1999), 79(2), 323-332

Summary We compared the flow cytometric measurement and analysis of the potential doubling time ( Tpot) between three centres involved in the National Cancer Institute (NCI) protocol T92-0045. The primary ... [more ▼]

Summary We compared the flow cytometric measurement and analysis of the potential doubling time ( Tpot) between three centres involved in the National Cancer Institute (NCI) protocol T92-0045. The primary purpose was to understand and minimize the variation within the measurement. A total of 102 specimens were selected at random from patients entered into the trial. Samples were prepared, stained, run and analysed in each centre and a single set of data analysed by all three centres. Analysis of the disc data set revealed that the measurement of labelling index (LI) was robust and reproducible. The estimation of duration of S-phase ( Ts) was subject to errors of profile interpretation, particularly DNA ploidy status, and analysis. The LI dominated the variation in Tpot such that the level of final agreement, after removal of outliers and ploidy agreement, reached correlation coefficients of 0.9. The sample data showed poor agreement within each of the components of the measurement. There was some improvement when ploidy was in agreement, but correlation coefficients failed to exceed values of 0.5 for Tpot. The data suggest that observer-associated analysis of Ts and tissue processing and tumour heterogeneity were the major causes of variability in the Tpot measurement. The first two aspects can be standardized and minimized, but heterogeneity will remain a problem with biopsy techniques. [less ▲]

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See detailCAPPP trial. Captopril Prevention Project.
Scheen, André ULg

in Lancet (1999), 353(9166), 1793-41795-6

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See detailRevision of the late Famennian Miospore Zonation scheme in eastern Belgium.
Maziane, N.; Higgs, K.T.; Streel, Maurice ULg

in Journal of Micropalaeontology (1999), 18

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See detailHyperfractionated accelerated radiotherapy (HART) for inoperable, non metastatic non-small-cell lung carcinoma of the lung (NSCLC): result of a phase II study for patients ineligible for combination radio-chemotherapy.
Koutaissoff, S; Wellmann, D; COUCKE, Philippe ULg et al

in International Journal of Radiation, Oncology, Biology, Physics (1999), 45(5), 1151-1156

Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination ... [more ▼]

Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination radiochemotherapy studies. Methods and Materials: From February 1989 through August 1994, 23 patients ineligible for available combined modality protocols in our institution were enrolled and treated with HART, consisting of 63 Gy given in 42 fractions of 1.5 Gy each, twice daily, with a minimum time interval of 6 h between fractions, 5 days a week, over an elapsed time of 4.2 weeks, or 29 days. There was no planned interruption. Results: The 1-, 2-, and 3-year survival rates were 61%, 39%, and 19%, respectively, with a median survival of 16.8 months. At the time of analysis, 4 patients are alive and 19 have died, 16 from NSCLC and 3 from cardiacdisease. Overall response rate was 48%, with 22% of patients achieving a complete response and 26% a partial response. Correlation between acute response rate and survival was poor. First site of relapse was local-regional in 8 patients (35%), distant in 6 patients (26%), and local-regional and distant in 4 (17%) patients. One patient had Grade IV and 2 had Grade III esophagitis. One patient presented with chronic Grade III lung toxicity. There were no treatment-related deaths. Conclusion: In this group of 23 patients ineligible for radiochemotherapy, this HART regime was quite feasible and was followed by little toxicity. Results in this particularly poor prognosis NSCLC patient category should be compared to series with a similar patient profile; however, median survival is at least similar to that obtained in recent series of combination radiochemotherapy. © 1999 Elsevier Science Inc. [less ▲]

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See detailGenes for rare idiopathic generalized epilepsies: BFNC.
Singh, N.; Charlier, Carole ULg; Peiffer, A. et al

in Advances in neurology (1999), 79

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See detailL'ostéoarthrose chez le chien - Pathophysiologie et diagnostic
Loneux, P.; Balligand, Marc ULg

in Annales de Médecine Vétérinaire (1999), (143), 153-160

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See detailA Basis for Using Fire Modeling with 1-D Thermal Analyses of Partitions to Simulate 2-D and 3-D Structural Performance in Real Fires
Cooper, Len; Franssen, Jean-Marc ULg

in Fire Safety Journal (1999), 33

A basis is presented for identifying partition design for which: 1) the use of one-dimensional thermal analysis in the fire modeling part of the problem would lead to reliable simulations of the fire ... [more ▼]

A basis is presented for identifying partition design for which: 1) the use of one-dimensional thermal analysis in the fire modeling part of the problem would lead to reliable simulations of the fire environment, and 2) the resulting simulations can be used to provide the necessary boundary conditions input to solve the thermal/structural part of the problem, using two- or three-dimensional analyses, as required. [less ▲]

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See detailParticularités de la contraction électro-induite : implications rééducatives
Vanderthommen, Marc ULg; Zahlan, O.; BAUVIR, Philippe ULg et al

in Kine 2000 (1999), 10

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See detailBiochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the alpha-methyl-L-tryptophan method.
Gharib, Abdallah; Balende, Cédar; Sarda, Nicole et al

in Journal of Neurochemistry (1999), 72(6), 2593-600

Biochemical approaches were used in freely moving rats to determine, under steady-state conditions, the brain/arterial plasma partition coefficients of L-tryptophan and alpha-[3H]methyl-L-tryptophan, from ... [more ▼]

Biochemical approaches were used in freely moving rats to determine, under steady-state conditions, the brain/arterial plasma partition coefficients of L-tryptophan and alpha-[3H]methyl-L-tryptophan, from which the lumped constant for the alpha-methyl-L-tryptophan method of estimating the rate of brain serotonin synthesis is calculated. The lumped constants were significantly different in the various structures examined: 0.149 +/- 0.003 in the raphe dorsalis, 0.103 +/- 0.002 in the raphe centralis, 0.087 +/- 0.003 in the reticular formation, and 0.62 +/- 0.08 in the pineal gland. From these data we proposed a two-compartment model to calculate the rate of serotonin synthesis by quantitative autoradiography using a three-time point experiment. Rates of synthesis for the raphe dorsalis and the reticular formation (620 +/- 57 and 80 +/- 35 pmol/g of tissue/min, respectively) were similar to those measured simultaneously by biochemical means, but rates were 50% higher for the raphe centralis (568 +/- 90 vs. 381 +/- 31 pmol/g of tissue/min). The lack of dynamic equilibrium of the tracer between plasma and tissue pools may explain the discrepancy between the two methods. Our findings did not confirm previous data, indicating that the application of the autoradiographic method to measure the rate of brain serotonin synthesis using alpha-methyl-L-tryptophan as tracer has limitations. [less ▲]

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See detailOral status and nutrition in the institutionalized elderly.
Lamy, Marc ULg; Mojon, P.; Kalykakis, G. et al

in Journal of Dentistry (1999), 27(6), 443-8

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more ... [more ▼]

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more subjective eating difficulty and increased mashed food consumption. METHODS: An oral examination and an evaluation of masticatory capacity were performed on 120 institutionalized elderly subjects. The nutritional assessment included serum albumin concentration, the Mini Nutritional Assessment and a questionnaire on eating habits. RESULTS: Edentulous subjects without dentures or with only one complete denture had significantly lower MNA scores than edentulous subjects with two complete dentures (p < 0.05). Edentulous subjects with two complete dentures more frequently reported taking pleasure from eating (p = 0.05), and had less frequent difficulties with hard foods (p = 0.01) than edentulous subjects without dentures or with only one complete denture. Mashed food consumption (p < 0.01) was also reported more frequently in edentulous subjects without dentures or with only one complete denture. Subjects with two complete dentures had similar or better MNA scores as dentate subjects with relatively few remaining teeth (10.4 +/- 7.8 teeth). About half of the subjects (53%) could not perform the masticatory test. These subjects had lower MNA scores (p = 0.001) and a larger proportion ate mashed food (p < 0.001) compared to those who were able to perform the test. CONCLUSIONS: Poor oral status (edentulous without dentures or with only one complete denture) increased difficulty in eating hard foods, increased mashed food consumption and decreased eating pleasure. It seemed also to put institutionalized subjects at higher risk of undernutrition. [less ▲]

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See detailLa cartographie des contraintes karstiques en Région wallonne (Belgique)
Ek, Camille ULg; Michel, Raymond; Jaspar, Annick

in Bulletin de la Société Géographique de Liège (1999), 36

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See detailLa mortalité embryonnaire. 2. Implications hormonales
Hanzen, Christian ULg; Lourtie, O.; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailEtude des hypothèses de l'analyse de la variance à deux critères de classification : approche par l'exemple
Iemma, A. F.; Claustriaux, Jean-Jacques ULg

in Notes de Statistique et d'Informatique (1999), (3), 36

By examples and results from SAS and Minitab softwares (GLM), analysis of variance hypothesis built to analyse a two dimensional data table are introduced.

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See detailLe Traçage : un outil pour l'établissement des zones de surveillance des captages en terrain karstique. Le cas de Hastière (Province de Namur, Belgique)
Michel, Goerges; Meus, Philippe ULg; Thys, Georges et al

in Bulletin de la Société Géographique de Liège (1999), 37

In response to the request of the Groundwater Service of the Walloon Region, the Commission Wallonne d'Etude et de Protection des Sites Souterrains (CWEPSS) has carried out underground water tracing in ... [more ▼]

In response to the request of the Groundwater Service of the Walloon Region, the Commission Wallonne d'Etude et de Protection des Sites Souterrains (CWEPSS) has carried out underground water tracing in the karstic area of Hastière (Province of Namur, Belgium).The CWEPSS has carried on the task with the cooperation of Geologica SA, Gembloux, for the tracing tests and the collaboration of the Université de Liège for several related parameters (stream gauging, water analyzes, spectrofluorimetry, etc.). At Hastière, several karstic Springs resurge from a large and complex limestone syncline; two water supply stations pump water from this syncline for local use. Fluorescent tracers have been injected into three swallowholes. Three different tracers have been used simultaneously - one in each injection site. They have been traced downstream in 9 potential points of reappearance. In a single one-month field-campaign, the origin of 9 streams has been questioned. Despite the low-water levels during this period, some underground streams have covered more than 3,5 km in 8 days. This shows how important is to permanently watch water supplies in karstic areas. The water intake of the Municipality at Anthée proved to be clean, unpolluted. The authors could define the watch-zone and delineate a prioritary watch sub-zone in the geological formation supplying directly the intake. A private camping intake appeared to be supplied by a sinkhole collecting water from a water purifying station and by another sinking stream swallowing sewage water, hence a high pollution and an important sanitary problem. These findings, among others, show how us « the water tracing technique is in detecting sources and in defining watch and protection zones. [less ▲]

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See detailIndices d'aptitude des procédés de production
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1999), (5), 26

This note describes the main process capability indices and presents some inferential porperties. A numerical example is analysed by Minitab and SAS softwares.

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See detailIdentification Of Cystosolic Mg2+-Dependent Soluble Inorganic Pyrophosphatases In Potato And Phylogenetic Analysis
Rojas-Beltran, Ja.; Dubois, Françoise ULg; Mortiaux, F. et al

in Plant Molecular Biology (1999), 39(3),

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See detailAnalyse préliminaire de la situation et des perspectives de la culture du haricot de Lima (Phaseolus lunatus L.) sur la Côte péruvienne (Vallées d'Ica, Pisco et Casma).
Rouschop, P.; Baudoin, Jean-Pierre ULg; Mayta, F. C. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(2), 115-126

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See detailThe influence of tissular cross-talking on osteoarthritis progression: role of non steroidal antiinflammatory drugs
Pelletier, JP; Reginster, Jean-Yves ULg

in Osteoarthritis and Cartilage (1999), 7

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See detailModélisation de la mise en oeuvre des boulons sertis précontraints
Drean, M.; Habraken, Anne ULg; Bouchair, A. et al

in Construction Métallique (1999), 4

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See detailCBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein
Chariot, Alain ULg; Van Lint, Carine; Chapelier, Muriel et al

in Oncogene (1999), 18

Homeodomain-containing proteins are transcription factors regulating the coordinated expression of multiple target genes involved in development, differentiation and cellular transformation. In this study ... [more ▼]

Homeodomain-containing proteins are transcription factors regulating the coordinated expression of multiple target genes involved in development, differentiation and cellular transformation. In this study, we demonstrated that HOXB7, one member of this family, behaved as a transactivator in breast cancer cells. Deletion of either the HOXB7 N-terminal domain or the C-terminal acidic tail abolished this transcriptional effect, suggesting a combination of distinct functional transactivating domains. HOXB7 physically interacted both in vitro and in vivo with the coactivator CREB-binding protein (CBP). This interaction led to an enhanced transactivating potential and required the N-terminal of HOXB7 as well as two domains located at the C-terminal part of CBP. Moreover, trichostatin A, a deacetylase inhibitor, strongly enhanced the transcriptional properties of HOXB7. Our data therefore indicate that HOX proteins can directly interact with CBP and that acetylation/deacetylation may regulate their transcriptional properties. [less ▲]

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See detailComment j'explore ... une suspicion de sténose d'artère rénale
Krzesinski, Jean-Marie ULg; Turatzinze, Léopold

in Revue Médicale de Liège (1999), 54(8), 702-704

Renal artery stenosis can present 2 clinical pictures, sometimes associated and potentially treatable, due mainly to atherosclerosis, but also to fibromuscular dysplasia. The first possible presentation ... [more ▼]

Renal artery stenosis can present 2 clinical pictures, sometimes associated and potentially treatable, due mainly to atherosclerosis, but also to fibromuscular dysplasia. The first possible presentation is renovascular hypertension which represents 1% of unselected hypertensive populations. The second possible presentation is ischemic renal disease, which represent 10% of the new indications for dialysis therapy and has a 50% mortality rate at 3 years. To explore this disease, arteriography, the gold standard, must be reserved for confirmation and treatment. Hypertension induced by the stenosis is best approached by captopril renal MAG 3 scintigraphy. Measurement of the stenosis severity can be performed either by duplex ultrasonography, magnetic resonance angiography or spinal CT angiography according to patients'characteristics, local experience and facilities. This disease must be searched in the presence of renal insufficiency of unknown cause or refractory hypertension. [less ▲]

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See detailPrise en charge médico-chirurgicale des enfants cardiopathes: résultats de l'expérience liégeoise
Massin, M.M.; RADERMECKER, Marc ULg; Jalali, H. et al

in Revue Médicale de Liège (1999), 54(2), 95-9

OBJECTIVE: Evaluation of the results obtained in the management of congenital heart diseases in Liege. MATERIAL AND METHODS: We evaluated the results, the mortality and the morbidity of diagnostic and ... [more ▼]

OBJECTIVE: Evaluation of the results obtained in the management of congenital heart diseases in Liege. MATERIAL AND METHODS: We evaluated the results, the mortality and the morbidity of diagnostic and interventional cardiac catheterization, and of the cardiac surgery in the 123 cardiac children who were referred to us during the three first years of operation of our medico-surgical team. RESULTS: 89 children underwent a catheterization, including 12 therapeutic interventions, whereas 68 were operated. In the two domains, the results are completely comparable with those of the established centers. CONCLUSIONS: The widening of the activity of paediatric cardiology and the creation of an activity of pediatric cardiac surgery in Liege appeared important to us for the quality of management of the cardiac children. This goal could be reached only if our results were comparable with those of the literature. The bet seems to be held. The ultimate objective is to contribute by an adequate policy of management to the quality of life and the health of the cardiac children. [less ▲]

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See detailHarm avoidance and serotonin.
Hansenne, Michel ULg; Ansseau, Marc ULg

in Biological Psychology (1999), 51(1), 77-81

The relationships between the Tridimensional Personality Questionnaire (TPQ) and serotonergic activity has been described in some studies with controversial results. These studies have focused on specific ... [more ▼]

The relationships between the Tridimensional Personality Questionnaire (TPQ) and serotonergic activity has been described in some studies with controversial results. These studies have focused on specific patient populations rather than normal controls. Therefore, the aim of the present study is to examine the relationships between the TPQ and serotonergic activity in a group of non-patient subjects. Twenty-three normal subjects answered the TPQ, and the serotonergic activity was assessed by the prolactin response to a highly potent and selective 5-HT1a agonist (flesinoxan). A positive relationship between harm avoidance and PRL response to flesinoxan was found. This study is consistent with the hypothesized link between serotonergic activity and the harm avoidance dimension of the biosocial model of Cloninger. [less ▲]

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See detailScintigraphy of the equine lung
Votion, Dominique ULg; Lekeux, Pierre ULg

in Equine Veterinary Education (1999), 11

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See detailAllozymic variation and genetic structure of Scottish Calluna vulgaris populations the effect of postglacial recolonization
Mahy, Grégory ULg; Ennos, Richard; Jacquemart, Anne Laure

in Heredity (1999), 82

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See detailInsertion Of Escherichia Coli Alpha-Haemolysin In Lipid Bilayers As A Non-Transmembrane Integral Protein: Prediction And Experiment
Soloaga, A.; Veiga, Mp.; Garcia-Segura, Lm. et al

in Molecular Microbiology (1999), 31(4), 1013-24

alpha-Haemolysin is an extracellular protein toxin (approximately 107 kDa) secreted by Escherichia coli that acts at the level of the plasma membranes of target eukaryotic cells. The nature of the toxin ... [more ▼]

alpha-Haemolysin is an extracellular protein toxin (approximately 107 kDa) secreted by Escherichia coli that acts at the level of the plasma membranes of target eukaryotic cells. The nature of the toxin interaction with the membrane is not known at present, although it has been established that receptor-mediated binding is not essential. In this work, we have studied the perturbation produced by purified alpha-haemolysin on pure phosphatidylcholine bilayers in the form of large unilamellar vesicles, under conditions in which the toxin has been shown to induce vesicle leakage. The bilayer systems containing bound protein have been examined by differential scanning calorimetry, fluorescence spectroscopy, differential solubilization by Triton X-114, and freeze-fracture electron microscopy. All the data concur in indicating that alpha-haemolysin, under conditions leading to cell lysis, becomes inserted in the target membrane in the way of intrinsic or integral proteins. In addition, the experimental results support the idea that inserted alpha-haemolysin occupies only one of the membrane phospholipid monolayers, i.e. it is not a transmembrane protein. The experimental data are complemented by structure prediction studies according to which as many as ten amphipathic alpha-helices, appropriate for protein-lipid interaction, but no hydrophobic transmembrane helices are predicted in alpha-haemolysin. These observations and predictions have important consequences for the mechanism of cell lysis by alpha-haemolysin; in particular, a non-transmembrane arrangement of the toxin in the target membrane is not compatible with the concept of alpha-haemolysin as a pore-forming toxin. [less ▲]

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See detailHousekeeping Genes as Internal Standards: Use and Limits
Thellin, Olivier ULg; Zorzi, Willy ULg; Lakaye, Bernard ULg et al

in Journal of Biotechnology (1999), 75(2-3), 291-5

Quantitative studies are commonly realised in the biomedical research to compare RNA expression in different experimental or clinical conditions. These quantifications are performed through their ... [more ▼]

Quantitative studies are commonly realised in the biomedical research to compare RNA expression in different experimental or clinical conditions. These quantifications are performed through their comparison to the expression of the housekeeping gene transcripts like glyceraldehyde-3-phosphate dehydrogenase (G3PDH), albumin, actins, tubulins, cyclophilin, hypoxantine phsophoribosyltransferase (HRPT), L32. 28S, and 18S rRNAs are also used as internal standards. In this paper, it is recalled that the commonly used internal standards can quantitatively vary in response to various factors. Possible variations are illustrated using three experimental examples. Preferred types of internal standards are then proposed for each of these samples and thereafter the general procedure concerning the choice of an internal standard and the way to manage its uses are discussed. [less ▲]

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See detailConcentrations plasmatiques de la vitamine K1 et de l'acenocoumarol en fonction du temps de quick (I.N.R.)
Gougnard, Thierry; Charlier, Corinne ULg; David, Jean-Louis ULg et al

in Acta Clinica Belgica. Supplementum (1999), S1

Reduced vitamins K are acting as cofactors of glutamic carboxylation of procoagulant factors (II, VII, IX and X). The reduction of these vitamins is inhibited by oral anticoagulants. The response to ... [more ▼]

Reduced vitamins K are acting as cofactors of glutamic carboxylation of procoagulant factors (II, VII, IX and X). The reduction of these vitamins is inhibited by oral anticoagulants. The response to antivitamins K is individual and may change during the treatment of a patient. The determinations of plasmatic vitamin K and acenocoumarol may help to explain the mechanism of a resistance to the anticoagulant therapy. Quantifications of vitamin K1 are realized after liquid-liquid extraction with liquid chromatography and fluorescence detection after post-column reduction. For acenocoumarol, plasma concentration is measured, after liquid-liquid extraction, by liquid chromatograph, with ion trap mass spectrometer detector. [less ▲]

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See detailHypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction.
Minet, E.; Mottet, Denis ULg; Michel, G. et al

in FEBS Letters (1999), 460(2), 251-6

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear ... [more ▼]

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear translocator (ARNT)-Sim (PAS) factors Sim and aryl hydrocarbon receptor (Ahr). The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), involved in the response to hypoxia, also belongs to the bHLH-PAS family. This work was aimed to investigate the putative role of Hsp90 in HIF-1 activation by hypoxia. Using a EGFP-HIF-1alpha fusion protein, co-immunoprecipitation experiments evidenced that the chimeric protein expressed in COS-7 cells interacts with Hsp90 in normoxia but not in hypoxia. We also demonstrated that Hsp90 interacts with the bHLH-PAS domain of HIF-1alpha. Moreover, Hsp90 is not co-translocated with HIF-1alpha into the nucleus. At last, we showed that Hsp90 activity is essential for HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin. These results indicate that Hsp90 is a major regulator in HIF-1alpha activation. [less ▲]

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See detailLyapunov functions for stable cascades and applications to global stabilization
Mazenc, F.; Sepulchre, Rodolphe ULg; Jankovic, M.

in IEEE Transactions on Automatic Control (1999), 44(9), 1795-1800

This paper generalizes recent Lyapunov constructions for a cascade of two nonlinear systems one of which is stable rather than asymptotically stable. A new a cross term construction in the Lyapunov ... [more ▼]

This paper generalizes recent Lyapunov constructions for a cascade of two nonlinear systems one of which is stable rather than asymptotically stable. A new a cross term construction in the Lyapunov function allows us to replace earlier growth conditions by a necessary boudedness condition. This method is instrumental in the global stabilization of feedforward systems and new stabilization results are derived from the generalized construction. [less ▲]

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See detailDepressive vulnerability is not an independent risk factor for osteoporosis in postmenopausal women.
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Paul, I. et al

in Maturitas (1999), 33(2), 133-7

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy ... [more ▼]

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy postmenopausal women, whether depressive symptomatology, assessed by the General Health Questionnaire (GHQ), was associated to a significant decrease in BMD, hence supporting the hypothesis of an independent pathogenetic link between the two disorders. We investigated 121 postmenopausal women, aged 48-77 years, spontaneously attending a screening visit for osteoporosis in an outpatient facility. BMD of the spine and the non-dominant hip (total and neck areas) were measured by Dual Energy X-Ray absorptiometry. All subjects completed to the 'General Health Questionnaire' translated and validated in French. No significant correlations were observed between the GHQ score and BMD of the spine (P = 0.54), the total hip area (P = 0.65), or the femoral neck area (P = 0.65). No differences in terms of spinal or femoral BMD were observed between women with GHQ score < 5 or > or = 5. When comparing values of BMD between women within the upper and the lower quartiles for GHQ score, no difference was observed for spine (P = 0.69), total hip (P = 0.80), or femoral neck (P = 0.93). Similarly, GHQ scores were not significantly different when comparing women in the upper and lower quartiles of BMD distribution at the spine or the hip. In conclusion, notwithstanding the clinical pattern of postmenopausal osteoporosis can lead to depression and, on the other hand, hormonal and behavioral disturbances reported in depression might be enhancing factors for accelerated bone loss, our present results do not support the hypothesis that otherwise healthy postmenopausal women with increased depressive complaints are also more prone to exhibit osteoporotic fractures. [less ▲]

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See detailHighly stereoselective ruthenium-catalyzed ring-opening metathesis polymerization of 2,3-difunctionalized norbornadienes and their 7-oxa analogues
Delaude, Lionel ULg; Demonceau, Albert ULg; Noels, Alfred ULg

in Macromolecules (1999), 32(7), 2091-2103

The ring-opening metathesis polymerization (ROMP) of 2,3-difunctionalized norbornadienes and their 7-oxa analogues catalyzed by [RuCl2(p-cymene)](2) in the presence of trimethylsilyldiazomethane (TMSD ... [more ▼]

The ring-opening metathesis polymerization (ROMP) of 2,3-difunctionalized norbornadienes and their 7-oxa analogues catalyzed by [RuCl2(p-cymene)](2) in the presence of trimethylsilyldiazomethane (TMSD) yields high-trans, highly tactic polymers. A tentative mechanism involving arene loss, carbene formation, and monomer chelation is presented. The ROMP of 2,3-dicarbomethoxynorbornadiene served as a test reaction to investigate the influence of the various experimental parameters (reaction time and temperature, nature of the solvent and catalyst, and TMSD initiation conditions). An all-trans, highly tactic (>79%) polymer was obtained under a wide variety of conditions. Strikingly, the addition of tricyclohexylphosphine had a detrimental influence on the polymerization yield and stereoselectivity. The procedure was successfully applied to various other 2,3-dicarboalkoxynorbornadienes, benzonorbornadiene, and their 7-oxa analogues. In the case of the diester monomers, an increase in the alkyl substituent size led to a decrease of the polymer trans content and tacticity. Because of the ruthenium catalyst's ready availability and marked resistance to oxygen and water, reactions were very easy to set up and to carry out. [less ▲]

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See detailTwo new aminopeptidases from Ochrobactrum anthropi active on D-alanyl-p-nitroanilide.
Fanuel, L; Thamm, Iris ULg; Kostanjevecki, V et al

in Cellular and Molecular Life Sciences : CMLS (1999), 55(5), 812-8

Two new enzymes which hydrolyse D-alanyl-p-nitroanilide have been detected in Ochrobactrum anthropi LMG7991 extracts. The first enzyme, DmpB, was purified to homogeneity and found to be homologous to the ... [more ▼]

Two new enzymes which hydrolyse D-alanyl-p-nitroanilide have been detected in Ochrobactrum anthropi LMG7991 extracts. The first enzyme, DmpB, was purified to homogeneity and found to be homologous to the Dap protein produced by O. anthropi SCRC C1-38 (ATCC49237). The second enzyme, DmpA, exhibits a similar substrate profile when tested on p-nitroanilide derivatives of glycine and L/D-alanine, but the amounts produced by the Ochrobactrum strain were not sufficient to allow complete purification. Interestingly, the DmpA preparation also exhibited an L-aminopeptidase activity on the tripeptide L-Ala-Gly-Gly but it was not possible to be certain that the same protein was responsible for both p-nitroanilide and peptide hydrolysing activities. The gene encoding the DmpA protein was cloned and sequenced. The deduced protein sequence exhibits varying degrees of similarity with those corresponding to several open reading frames found in the genomes of other prokaryotic organisms, including Mycobacteria. None of these gene products has been isolated or characterised, but a tentative relationship can be proposed with the NylC amidase from Flavobacterium sp. K172. [less ▲]

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See detailMorphologie, distribution et écologie comparées d'Amblystegium tenax et d'A. fluviatile en Belgique
Vanderpoorten, Alain ULg; Empain, Alain ULg

in Belgian Journal of Botany (1999), 132(1), 3-12

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See detailLes Caecilii, la Sicile et le judaïsme
Rochette, Bruno ULg

in Maia (1999), 51

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See detailHuman Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.
Colige, Alain ULg; Sieron, A. L.; Li, S. W. et al

in American Journal of Human Genetics (1999), 65(2), 308-17

Ehlers-Danlos syndrome (EDS) type VIIC is a recessively inherited connective-tissue disorder, characterized by extreme skin fragility, characteristic facies, joint laxity, droopy skin, umbilical hernia ... [more ▼]

Ehlers-Danlos syndrome (EDS) type VIIC is a recessively inherited connective-tissue disorder, characterized by extreme skin fragility, characteristic facies, joint laxity, droopy skin, umbilical hernia, and blue sclera. Like the animal model dermatosparaxis, EDS type VIIC results from the absence of activity of procollagen I N-proteinase (pNPI), the enzyme that excises the N-propeptide of type I and type II procollagens. The pNPI enzyme is a metalloproteinase containing properdin repeats and a cysteine-rich domain with similarities to the disintegrin domain of reprolysins. We used bovine cDNA to isolate human pNPI. The human enzyme exists in two forms: a long version similar to the bovine enzyme and a short version that contains the Zn++-binding catalytic site but lacks the entire C-terminal domain in which the properdin repeats are located. We have identified the mutations that cause EDS type VIIC in the six known affected human individuals and also in one strain of dermatosparactic calf. Five of the individuals with EDS type VIIC were homozygous for a C-->T transition that results in a premature termination codon, Q225X. Four of these five patients were homozygous at three downstream polymorphic sites. The sixth patient was homozygous for a different transition that results in a premature termination codon, W795X. In the dermatosparactic calf, the mutation is a 17-bp deletion that changes the reading frame of the message. These data provide direct evidence that EDS type VIIC and dermatosparaxis result from mutations in the pNPI gene. [less ▲]

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See detailEvaluation of implantation procedures for PIT tagging juvenile Nile tilapia
Baras, E.; Westerloppe, L.; Mélard, Charles ULg et al

in North American Journal of Aquaculture (1999), 61

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See detailDo leaching experiments affect the Sm-Nd signature of deep-sea sediments? The example of the northern North Atlantic
Innocent, Christophe; Fagel, Nathalie ULg; Stevenson, Ross

in Canadian Journal of Soil Science (1999), 79

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See detailFinancement des cultes et Impôt Philosophiquement Dédicacé : éléments budgétaires et aspects pratiques
Husson, Jean-François ULg

in Revue Politique (La) (1999), (4-5), 47-87

This article reviews the channels and amounts of public financing for religious and philosophical communities in Belgium and confronts them with possibile alternatives, most notably the "impot ... [more ▼]

This article reviews the channels and amounts of public financing for religious and philosophical communities in Belgium and confronts them with possibile alternatives, most notably the "impot philosophiquement dedicacé" (or the affectation of a percentage of the income tax). [less ▲]

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See detailIdentification of mechanisms involved in the acute airway toxicity induced by parathion.
Segura, P.; Chavez, J.; Montano, L. M. et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1999), 360(6), 699-710

Organophosphates are still widely used worldwide and cause thousands of intoxications every year. In this work we investigated the mechanisms of parathion (Pth) airway toxicity, using biochemical and ... [more ▼]

Organophosphates are still widely used worldwide and cause thousands of intoxications every year. In this work we investigated the mechanisms of parathion (Pth) airway toxicity, using biochemical and functional approaches. A plethysmographic technique for unrestrained guinea pigs was used to analyze Pth-induced modifications of airway mechanics and responsiveness to acetylcholine (ACh: 0.1-3.2 mg/ml, 2-min inhalation each dose). The isolated perfused rabbit lung preparation was used to study the acute effects of Pth on airway responsiveness to ACh (10(-8)-10(-3) M), histamine (10(-8)-10(-3) M) and substance P (10(-10)-10(-6) M), pulmonary acetylcholinesterase inhibition and cytochrome P450 (P450) activity, and their modifications with previous administration of Pth (1 mg/kg s.c. daily, 7 days). We found that: (1) In guinea pigs Pth (3.2-17 mg/kg i.p.) produced a dose-dependent increase in a lung resistance index (iRL), which was greatly reverted (approximately 50%) by salbutamol (2 mg/ml, 2-min inhalation, or 10 microg/kg i.p.). This salbutamol effect was transient (5-10 min), suggesting that this bronchodilator triggered additional obstructive mechanisms. (2) Pth increased the water content in lung parenchyma samples, but not in trachea or bronchi, and augmented the respiratory secretions measured through monosaccharide content in bronchoalveolar lavage. (3) The increase in iRL was greater in female animals, probably due to a higher P450 basal activity, and completely blocked by pharmacological inhibition of P450 with piperonyl butoxide (500 mg/kg i.p.). (4) In male guinea pigs a subclinical dose of Pth (10 mg/kg i.p.) induced airway hyperresponsiveness to ACh. In isolated perfused rabbit lung Pth (10(-6) M) produced airway hyperresponsiveness to ACh and histamine, the latter prevented by atropine (10(-5) M). (5) Repetitive exposure to subclinical doses (1 mg/kg s.c.) of Pth during 1 week caused approximately 80% inhibition of P450 activity in rabbits, which was not enough, however, to prevent the functional manifestation of Pth toxicity in the airways. [less ▲]

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See detailAnalysis of Factors Influencing Long-Term Survival after Surgical Resection for Oesophageal Squamous Cell Carcinoma
Kolh, Philippe ULg; Honore, Pierre ULg; Gielen, J. L. et al

in Acta Chirurgica Belgica (1999), 99(3, May-Jun), 113-8

OBJECTIVE: We evaluated prognostic factors in 34 patients discharged from hospital after surgical resection for oesophageal squamous cell carcinoma. MATERIAL AND METHODS: There were 22 males and 12 ... [more ▼]

OBJECTIVE: We evaluated prognostic factors in 34 patients discharged from hospital after surgical resection for oesophageal squamous cell carcinoma. MATERIAL AND METHODS: There were 22 males and 12 females; mean age was 59.3 years (range 42-77 years). Preoperative neoadjuvant treatment consisted in chemotherapy alone in three patients and in combined radiochemotherapy in 14. Digestive continuity was restored with a gastric transplant in 26 patients and a colonic graft in 8. Surgery was curative in 28 patients and palliative in 6. There were three stage I, 14 stage II, 13 stage III, and 4 stage IV diseases. In 19 patients the lymph nodes were invaded. The tumour was well differentiated in 17 patients, moderately in 9, and poorly in 8. RESULTS: Follow-up ranged from 2 to 100 months. Overall median postoperative survival was 21 months. By univariate analysis, factors influencing survival were curative surgery (p = 0.04), stage (p = 0.006), and nodal involvement (p = 0.0003). Nodal involvement was an independent prognostic factor by multivariate analysis (p = 0.0002). Patient age and sex, perioperative transfusion, digestive transplant, tumour local extension, grade of differentiation, and distant metastasis did not influence survival. Also, we did not observe any significant benefit of preoperative or postoperative chemotherapy or radiochemotherapy. CONCLUSIONS: Nodal involvement was the most important prognostic factor influencing survival. Therefore, an earlier diagnosis of oesophageal cancer in a less advanced stage is important to improve survival rates. Our study could not confirm the benefit of neoadjuvant therapy in terms of late survival. [less ▲]

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See detailLatest Devonian to Early Carboniferous biostratigraphy of Northern Brazil: an update.
Melo, JHG; Loboziak, S; Streel, Maurice ULg

in Bulletin du Centre de Recherches Elf Exploration Production (1999), 22(1), 13-33

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See detailUsing Confocal Microscopy to Study Virus Binding and Entry into Cells
Vanderplasschen, Alain ULg; Smith, G. L.

in Methods in Enzymology (1999), 307

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See detailEtude rétrospective de l'incidence des troubles nereux rapportés et suspects d'encéphalopathie spongiforme transmissible chez les bovins en Belgique
Saegerman, Claude ULg; Claes, M.; Vanopdenbosch, E. et al

in Epidémiologie et Santé Animale (1999), 35

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See detailLa prise de décisions pré-interactives dans l'enseignement des activités physiques et sportives
Cloes, Marc ULg; Pirottin, Véronique; Ledent, Maryse et al

in Revue de l'Education Physique (1999), 39(1), 25-36

Lorsqu'on tente de comprendre les comportements observés en classe, aborder la réflexion, les décisions et les valeurs des intervenants permet de mieux interpréter ce que l'on a observé. Cette démarche ... [more ▼]

Lorsqu'on tente de comprendre les comportements observés en classe, aborder la réflexion, les décisions et les valeurs des intervenants permet de mieux interpréter ce que l'on a observé. Cette démarche est évidemment délicate puisqu'il s'agit d'entrer dans un domaine sujet à des problèmes de crédibilité. Il est crucial de distinguer les valeurs et croyances, d'une part, et les prises de décisions, d'autre part. Celles-ci concernent deux moment de la relation pédagogique, ... [less ▲]

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See detailModelling of the liquid distribution in a trickle flow packed column based upon X-ray tomography images
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Chemical Engineering Communications (1999), 175

X-ray tomography is used to characterise the liquid distribution in a 0.6 meter diameter and 2 meter height column filled with gas-liquid absorption polypropylene packing elements (Cascade Mini-Ring 1A ... [more ▼]

X-ray tomography is used to characterise the liquid distribution in a 0.6 meter diameter and 2 meter height column filled with gas-liquid absorption polypropylene packing elements (Cascade Mini-Ring 1A, Glitsch Benelux). The liquid holdup distribution is determined for liquid flowrates ranging from 1000 l/h to 6000 l/h, that correspond to superficial velocities ranging from 10(-3) to 6 10(-3) m/s, in several cross sections situated at different heights in the packed column. A characteristic length, corresponding to the smallest scale beyond which the packing properties may be supposed statistically homogenous and isotropic, as determined by Means of the autocorrelation function method applied to the images of the solid distribution. Both local and global liquid holdup measurements are satisfactorily modelled by means of a partial wetting model based on a probabilistic approach. [less ▲]

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See detailHistidine modification and mutagenesis point to the involvement of a large conformational change in the mechanism of action of phage lambda lysozyme
Evrard, Christine ULg; Fastrez, Jacques; Soumillion, Patrice

in FEBS Letters (1999), 460

Phage lambda lysozyme is structurally related to other known lysozymes but its mechanism of action is different from the classical lysozyme mechanism, acting as a transglycosidase rather than a hydrolase ... [more ▼]

Phage lambda lysozyme is structurally related to other known lysozymes but its mechanism of action is different from the classical lysozyme mechanism, acting as a transglycosidase rather than a hydrolase. As two conformations have been revealed by the crystal structure, we investigated the effect of mutating and modifying a histidine located near to or far from the active site in the respective closed and open conformations. Whereas its asparagine mutation has little or no effect on activity, its N-carbethoxylation inactivates the enzyme. This provide further evidence for the involvement of the closed conformation and for the need of conformational mobility in lambda lysozyme function. [less ▲]

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See detailIdentification and characterization of mRNAs differentially expressed in thyroid cells stimulated by a mitogenic treatment
Pirson, I.; Behrens, J.; Savonet, V. et al

in Biochimie (1999), 81

he aim of our work is to identify new genes and proteins involved in the control of the proliferation of thyroid cells as putative protooncogenes and antioncogenes. Several strategies are discussed. A ... [more ▼]

he aim of our work is to identify new genes and proteins involved in the control of the proliferation of thyroid cells as putative protooncogenes and antioncogenes. Several strategies are discussed. A first study has allowed to identify three new genes. Further search will use the differential display and gene arrays methodology. The role of the identified proteins coded by the genes is studied in vitro by the search of partner proteins by the double hybrid method and in vivo by mice gene knockout technology [less ▲]

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See detailLes mesures provisoires en droit commercial international : développements récents au regard des Conventions de Bruxelles et de Lugano
Boularbah, Hakim ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1999)

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See detailComparison of necrotoxigenic Escherichia coli isolates from farm animals and humans
Mainil, Jacques ULg; Jacquemin, E.; Pohl, P. et al

in Veterinary Microbiology (1999), 70

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See detailEGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.
Du, G.; Willet, K.; Mouithys-Mickalad, Ange ULg et al

in Free Radical Biology & Medicine (1999), 27

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to ... [more ▼]

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to impair respiratory activities and mitochondrial oxidative phosphorylation efficiency. ADP/O (2.57 +/- 0.11) decreased after anoxia/reoxygenation (1.75 +/- 0.09, p < .01), as well as state 3 and uncoupled respiration (-20%, p < .01), but state 4 respiration increased (p < .01). EGb 761 (50-200 microg/ml) had no effect on mitochondrial functions before anoxia, but had a specific dose-dependent protective effect after anoxia/reoxygenation. When mitochondria were incubated with 200 microg/ml EGb 761, they showed an increase in ADP/O (2.09 +/- 0.14, p < .05) and a decrease in state 4 respiration (-22%) after anoxia/reoxygenation. In EPR spin-trapping measurement, EGb 761 decreased the EPR signal of superoxide anion produced during reoxygenation. In conclusion, EGb 761 specially protects mitochondrial ATP synthesis against anoxia/reoxygenation injury by scavenging the superoxide anion generated by mitochondria [less ▲]

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See detailDe Luikse regio: een gebied in verandering
Merenne-Schoumaker, Bernadette ULg

in De Aardrijkskunde (1999), (4), 3-44

Excusion booklet-guide in the Region of Liege with the aim to pin the principal changes occurred recently in the economy and within Liege spaces. Five parts : - a introduction presenting the program of ... [more ▼]

Excusion booklet-guide in the Region of Liege with the aim to pin the principal changes occurred recently in the economy and within Liege spaces. Five parts : - a introduction presenting the program of the excursion, - a short analysis of the town, - a recent assessment of the district econmy, - a general statistical file and - eleven thematic files devoted to eleven major points of the excusion [less ▲]

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See detailAnalysis of fluorescence lifetime of protochlorophyllide and chlorophyllide in isolated etioplast membranes measured from multifrequency cross-correlation phase fluorometry
Mysliwa-Kurdziel, B.; Franck, Fabrice ULg; Strzalka, K.

in Photochemistry & Photobiology (1999), 70(4), 616-623

The fluorescence decays of protochlorophyllide (Pchlide) and of chlorophyllide (Chlide) in wheat etioplast membranes were analyzed using a multiexponential fluorescence decay model. Using different ... [more ▼]

The fluorescence decays of protochlorophyllide (Pchlide) and of chlorophyllide (Chlide) in wheat etioplast membranes were analyzed using a multiexponential fluorescence decay model. Using different excitation wavelengths from 430 to 470 nm, we found that a triple-exponential model at 14 degrees C and a double-exponential model at -170 degrees C were adequate to describe the Pchlide fluorescence decay. We discuss the origin of the three fluorescence lifetime components at 14 degrees C on the basis of the dependence of their fractional intensities on the excitation wavelength and by correlating the fractional intensities with integrated fluorescence intensities of different Pchlide forms in steady-state fluorescence spectra, The fluorescence decay of the main Pchlide form, photoactive Pchlide-F657, is shown to have a complex character with a fast component of 0.25 ns and a slower component of about 2 ns. Two lifetime components of 2 ns and 5.5-6.0 ns are ascribed to the second photoactive form, Pchlide-F645, and to nonphotoactive Pchlide forms, respectively. In etioplast membranes preilluminated by a short saturating fight pulse, we found a single 5.0 ns component for Chlide-F688 (the Chlide-NADPH :protochlorophyllide oxidoreductase [POR]-NADP(+) complex) and an additional 1.6 ns component when the formation of Chlide-F696 (the Chlide-POR-NADPH complex) was promoted by exogenous NADPH, From the fluorescence lifetime results we evaluated the quantum yield of the primary photoreaction by Chlide-F696 as being 70%. [less ▲]

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See detailRecombinant Production Of The P10(Cks1at) Protein From Arabidopsis Thaliana And C-13 And N-15 Double-Isotopic Enrichment For Nmr Studies
Landrieu, I.; Casteels, P.; Odaert, B. et al

in Protein Expression & Purification (1999), 16(1),

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detailUnimolecular Dynamics from Kinetic Energy Release Distributions. V. How does the Efficiency of Phase Space Sampling vary with Internal Energy?
Hoxha, A.; Locht, Robert ULg; Lorquet, Andrée ULg et al

in Journal of Chemical Physics (1999), 111(20), 9259-9266

A retarding field technique coupled with a quadrupole mass analyzer has been used to obtain the kinetic energy release distributions (KERDs) for C2H3Br+->[C2H3]++Br dissociation as a function of the ... [more ▼]

A retarding field technique coupled with a quadrupole mass analyzer has been used to obtain the kinetic energy release distributions (KERDs) for C2H3Br+->[C2H3]++Br dissociation as a function of the internal energy. The KERDs obtained by dissociative photoionization using the He(I), Ne(I) and Ar(II) resonance lines were analyzed by the maximum entropy method and were found to be well described by introducing a single dynamical constraint, namely the relative translational momentum of the fragments. Ab initio calculations reveal the highly fluxional character of the C2H3+ ion. As the energy increases, several vibrational modes are converted in turn into large-amplitude motions. Our main result is that, upon increasing internal energy, the fraction of phase space sampled by the pair of dissociating fragments is shown to first decrease, pass through a shallow minimum around 75%, and then increase again, reaching almost 100% at high internal energies (8 eV). This behaviour at high internal energies is interpreted as resulting from the conjugated effect of intramolecular vibrational redistribution (IVR) and radiationless transitions among potential energy surfaces. Our findings are consistent with the coincidence data of Miller and Bear, reanalyzed here, and with the KERD of the metastable dissociation. [less ▲]

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See detailLa découverte d'or natif dans le quartzite devellien de Hourt autorise un autre regard sur le site de Rompt-le-Cou
Hanson, Alain ULg; Dehove, J.; Debbaut, Vincent ULg et al

in Glain et Salm. Haute Ardenne (1999), 51

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See detailLymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis.
Baert, F.; Wouters, K.; D'Haens, G. et al

in Gut (1999), 45(3), 375-81

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical ... [more ▼]

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS: Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS: Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis. [less ▲]

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See detailRecurrent abortion. Etiology and occurrence
VAN LINTHOUT, Christine ULg; Ahrendt, J.

in Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg (1999), (2), 59-71

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See detailMorphotypes et postures de vie et de mort chez les trilobites.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (1999), 56

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See detailEthanol induces taurine release in the amygdala: an in vivo microdialysis study
Quertemont, Etienne ULg; Dahchour, Abdelkhader; Ward, Roberta J. et al

in Addiction Biology (1999), 4

The effect of acute IP ethanol injections on the extracellular aspartate, glutamate, taurine and GABA content of the basolateral amygdala microdialysate was investigated in relationship with the total ... [more ▼]

The effect of acute IP ethanol injections on the extracellular aspartate, glutamate, taurine and GABA content of the basolateral amygdala microdialysate was investigated in relationship with the total brain ethanol content. Each acute intraperitoneal injection of ethanol, 0.5, 1.0, 2.0 and 3.0 g/kg body weight, induced an immediate increase in the microdialysate taurine content; both 0.5 and 1.0 g/kg ethanol evoked an increase during the first 20 minutes following injection which returned to baseline value by 40 minutes despite the fact that ethanol was detectable in the brain until 60 or 120 minutes respectively; after either 2.0 or 3.0 g/kg ethanol there was an increase in taurine content of gradual intensity which gradually declined to reach baseline values by 100 minutes. In contrast, the ethanol concentration for 2.0 g/kg remained elevated at the end of the 120 minutes approximately 25 mg ethanol / mg protein. The stimulated release of taurine within the amygdala could participate in the regulation of the ethanol-induced changes in osmolarity, since taurine is postulated to act as an osmoregulator in the brain. Taurine could also mediate or interact with the ethanol-induced CNS effects, as it exerts a modulatory action on cell excitability and neurotransmitter processes. [less ▲]

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See detailHas disinfection of endoscopes by automatic machines become obligatory?
Delwaide, Jean ULg; Pelckmans, P.; Defrance, P. et al

in Revue Médicale de Bruxelles (1999), 20(1), 49-50

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See detailImpairment of neocortical metabolism predicts progression in Alzheimer's disease
Herholz, K.; Nordberg, A.; Salmon, Eric ULg et al

in Dementia & Geriatric Cognitive Disorders (1999), 10(6), 494-504

Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset ... [more ▼]

Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible vs probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment. [less ▲]

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See detailKarst dans les micaschistes d'Akok Bekoé - Sud Cameroun
Willems, Luc ULg; Vicat, Jean-Paul; Pouclet, André

in Bulletin de la Société Géographique de Liège (1999), 37(2), 5-18

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those ... [more ▼]

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those found in the karst limestones. The presence of a spring and the proximity of the Nyong river suggest that a chemical erosion within an aquifer is at the origin of most of forms. The position of certain conduits and tafonis dismisses the assumption of a genesis within a weathering mantle. [less ▲]

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See detailEffect of synthesis process and substrate on electrical and thermal transport properties of Bi-2212
Dorbolo, Stéphane ULg; Ausloos, Marcel ULg; Bougrine, Hassan ULg et al

in Journal of Superconductivity (1999), 12(5), 623-629

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade ... [more ▼]

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade BaZrO3 substrate. Those measurements show that the BaZrO3 substrate gives better superconducting properties to the Bi-2212 than the Al2O3 substrate. The effect of (1.0 T) weak magnetic field has been searched for. The thermal magnetoconductivity and the contributions of the magnetic field to the thermoelectrical power are studied and compared through fine measurements. An electronic contribution seems to appear already well above the critical temperature and to exist up to 200 degrees K. The onset temperature is thus deduced. [less ▲]

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See detailThe Crystal Structure Of A Penicilloyl-Serine Transferase Of Intermediate Penicillin Sensitivity - The Dd-Transpeptidase Of Streptomyces K15
Fonze, E.; Vermeire, M.; Nguyen-Disteche, M. et al

in Journal of Biological Chemistry (1999), 274(31), 21853-60

The serine DD-transpeptidase/penicillin-binding protein of Streptomyces K15 catalyzes peptide bond formation in a way that mimics the penicillin-sensitive peptide cross-linking reaction involved in ... [more ▼]

The serine DD-transpeptidase/penicillin-binding protein of Streptomyces K15 catalyzes peptide bond formation in a way that mimics the penicillin-sensitive peptide cross-linking reaction involved in bacterial cell wall peptidoglycan assembly. The Streptomyces K15 enzyme is peculiar in that it can be considered as an intermediate between classical penicillin-binding proteins, for which benzylpenicillin is a very efficient inactivator, and the resistant penicillin-binding proteins that have a low penicillin affinity. With its moderate penicillin sensitivity, the Streptomyces K15 DD-transpeptidase would be helpful in the understanding of the structure-activity relationship of this penicillin-recognizing protein superfamily. The structure of the Streptomyces K15 enzyme has been determined by x-ray crystallography at 2.0-A resolution and refined to an R-factor of 18.6%. The fold adopted by this 262-amino acid polypeptide generates a two-domain structure that is close to those of class A beta-lactamases. However, the Streptomyces K15 enzyme has two particular structural features. It lacks the amino-terminal alpha-helix found in the other penicilloyl-serine transferases, and it exhibits, at its surface, an additional four-stranded beta-sheet. These two characteristics might serve to anchor the enzyme in the plasma membrane. The overall topology of the catalytic pocket of the Streptomyces K15 enzyme is also comparable to that of the class A beta-lactamases, except that the Omega-loop, which bears the essential catalytic Glu(166) residue in the class A beta-lactamases, is entirely modified. This loop adopts a conformation similar to those found in the Streptomyces R61 DD-carboxypeptidase and class C beta-lactamases, with no equivalent acidic residue. [less ▲]

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See detailSevere/extreme obesity: a medical disease requiring a surgical treatment?
Scheen, André ULg; Luyckx, Françoise ULg; Desaive, Claude ULg et al

in Acta Clinica Belgica (1999), 54(3), 154-61

Obesity poses a serious health hazard and its treatment is often disappointing. Surgical approaches have been proposed for treating severe obesity (body mass index or BMI > or = 35 kg/m2) with ... [more ▼]

Obesity poses a serious health hazard and its treatment is often disappointing. Surgical approaches have been proposed for treating severe obesity (body mass index or BMI > or = 35 kg/m2) with comorbidities or extreme obesity (BMI > or = 40 kg/m2). Before accepting bariatric surgery as alternative treatment, the four following prerequisites should be met: 1. the medical condition is serious enough; 2. it can not be treated satisfactorily with classical means; 3. the surgical treatment is effective in improving the clinical situation; and 4. bariatric surgery is safe enough, so that the benefits clearly outweigh the risks. On the basis of the literature and our own experience, it appears that gastric reduction surgery may be considered as a valuable alternative for treating severe/extreme obesity, despite the possible occurrence of perioperative and, more frequently, late complications, provided that it is performed by an experienced and multidisciplinary team in well-selected patients. [less ▲]

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See detailZoos, éducation et malentendus: Essai d'anthropologie des émotion du visiteur de zoo
Servais, Véronique ULg

in Cahiers d'Ethologie (1999), 19(1), 1-16

In the current debate about the zoo's educational role it s usually assumed that the emotional aspect of the zoo experience impairs the scienfic knowledge that people can gain from their visit. First we ... [more ▼]

In the current debate about the zoo's educational role it s usually assumed that the emotional aspect of the zoo experience impairs the scienfic knowledge that people can gain from their visit. First we briefly describe four human-animal interactionnal patterns that can be observed in a zoo, and we recognise that indeed, in that context, the emotion experienced by the public impairs its knowledge of the animals. then we persent the Hediger's distinctin between an object and a subject animal and we hypothesise that the visitor's emotions impari animal knowledge only when the exhibited animals are object-animals. Those are incomplete animals : they are not complete beings in relation to their evolutionary environment. It is our view that when the exhibited animals are more complete organisms, the emotions can be a tool for a better knowledge of the animals. [less ▲]

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See detailKarst dans les évaporites : marqueur efficace des événements récents. L’exemple du Mont Sédom (Israel)
Hallot, Eric ULg

in Bulletin de la Société Géographique de Liège (1999), 37

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See detailLa vasopressine, mais pas l'ocytocinen ni le CRF, est impliquée dans la réponse du cortisol aux stress pschologiques, chez des humains sains mais anxieux
Boudare, M; Pequeux, Christel ULg; Hagelstein, Marie-Thérèse ULg et al

in Annales d'Endocrinologie (1999), 60(4), 360

Le but général de cette étude est d'évaluer la réponse au stress, à la fois sous un angle psychologique et biologique, afin d'établir l'éventuel lien qui pourrait être observé entre ces deux paramètres.

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See detailTransport properties of bulk-bicrystal grain boundaries in artificially joined large-grain YBCO
Bradley, A. D.; Doyle, R. A.; Charalambous, D. et al

in IEEE Transactions on Applied Superconductivity (1999), 9(2), 2038-2041

A technique for joining large-grain YBCO has been used to produce bulk-bicrystal grain boundaries of different orientations. The behaviour of boundaries nominally of 0 degrees[100], 0 degrees[001] and ... [more ▼]

A technique for joining large-grain YBCO has been used to produce bulk-bicrystal grain boundaries of different orientations. The behaviour of boundaries nominally of 0 degrees[100], 0 degrees[001] and asymmetric 15 degrees[100]-tilt misorientation have been investigated using low frequency transport measurements in fields up to 7T. The boundaries exhibit a metallic normal state and a superconducting transition which broadens with increasing field having an irreversibility line which closely matches that of the adjoining grains. This same qualitative behaviour is seen in all the samples measured for field applied parallel and perpendicular to the c-axis and up to the highest current densities employed (20 Acm(-2)). Variation between the different samples due to microstructural differences are discussed. We interpret these results as strong suggestive evidence that this joining technique can be used to produce strongly-coupled large-grains for bulk-scale engineering applications. [less ▲]

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