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See detailCortical application of potassium chloride induces the low-molecular weight heat shock protein (Hsp27) in astrocytes.
Plumier, Jean-Christophe ULg; David, Jean-Claude; Robertson, H. A. et al

in Journal of Cerebral Blood Flow & Metabolism (1997), 17(7), 781-90

Spreading depression induces tolerance to ischemic injury, and ischemic tolerance has been associated with expression of heat shock proteins (Hsp). Here we examine Hsp27 expression after KCl-induced ... [more ▼]

Spreading depression induces tolerance to ischemic injury, and ischemic tolerance has been associated with expression of heat shock proteins (Hsp). Here we examine Hsp27 expression after KCl-induced spreading depression. Twenty-minute cortical KCl application induced Hsp27 immunoreactivity in glial fibrillary acidic protein-positive astrocytes of the ipsilateral neocortex. Systemic administration of MK-801 (3 mg/kg) suppressed KCl-induced Hsp27 expression in the parietal cortex. Astrocytes in the posterior cingulate and retrosplenial cortex did not express Hsp27 after KCl application but did express Hsp27 after systemic administration of high dose MK-801 (9 mg/kg). Whereas Hsp27 was usually observed in all layers of the parietal cortex after 5-minute application of KCl, in 2 of 6 rats, Hsp27 was seen in clusters of astrocytes or in astrocytes in the superficial layers I to III of the parietal cortex. We conclude that (1) cortical application of KCl triggered Hsp27 astrocytic expression; (2) astrocytes in the cingulate and retrosplenial cortex responded differently compared with astrocytes of the parietal cortex; (3) Hsp27 expression progressed from small clusters of astrocytes throughout superficial layers of the cortex that joined and recruited astrocytes in deeper layers; (4) several mechanisms induced Hsp27 astrocytic expression. We propose that Hsp27 is involved in spreading depression-induced ischemic tolerance through protection of astrocyte function. [less ▲]

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See detailEstimation d'un indice de la valeur récréative des forêts
Lejeune, Philippe ULg; Rondeux, Jacques ULg; Verstraete, Philippe

in Mitteilungen der Abteilung für Forstliche Biometrie (1997), 97(2), 20-30

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See detailTextural properties and thermal stability of silica-zirconia aerogels
Pirard, René ULg; Bonhomme, Damien; Kolibos, Sofia et al

in Journal of Sol-Gel Science and Technology (1997), 8

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See detailLa tracabilite des viandes.
Portetelle, Daniel ULg; Renaville, Robert ULg

in Annales de Gembloux (1997), 103(1-2),

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See detailThe TEL gene products: nuclear phosphoproteins with DNA binding properties.
Poirel, H.; Oury, Cécile ULg; Carron, Clémence et al

in Oncogene (1997)

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute ... [more ▼]

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events. [less ▲]

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See detailConstitutive expression of the 27-kDa heat shock protein (Hsp27) in sensory and motor neurons of the rat nervous system.
Plumier, Jean-Christophe ULg; Hopkins, D. A.; Robertson, H. A. et al

in Journal of Comparative Neurology (The) (1997), 384(3), 409-28

In this study, the constitutive expression of the 27-kDa heat shock protein (Hsp27) in the adult rat central nervous system has been examined by immunohistochemistry and by two-dimensional gel Western ... [more ▼]

In this study, the constitutive expression of the 27-kDa heat shock protein (Hsp27) in the adult rat central nervous system has been examined by immunohistochemistry and by two-dimensional gel Western blot analysis. Hsp27 immunoreactivity was observed primarily in motoneurons of cranial nerve nuclei and spinal cord, and in primary sensory neurons and their central processes. Also, Hsp27 immunoreactivity was present in neurons of the arcuate nucleus and of the reticular formation. However, only a subset of these neurons was Hsp27-immunoreactive. Most general somatic efferent motoneurons of the hypoglossal nucleus and spinal motor columns and most special visceral efferent motoneurons of the cranial nerve nuclei were Hsp27-positive. In contrast, fewer general somatic efferent motoneurons for eye muscles were Hsp27-positive, and only a small proportion of general visceral efferent neurons, i.e., parasympathetic and sympathetic preganglionic neurons, were stained for Hsp27. Many pseudounipolar sensory neurons were Hsp27-immunoreactive, and the patterns of staining in central sensory nuclei suggested that specific subpopulations of sensory neurons contained Hsp27. The cellular distribution of Hsp27 was uniform throughout the cytoplasm, including the perikaryon, axon and dendrites, the latter often exhibiting varicosities or beading in distal processes. Western blot analyses revealed that at least three phosphorylated isoforms of Hsp27 were present in the spinal cord. These results suggest that constitutively expressed Hsp27 may be related to functional subpopulations of motoneurons and primary sensory neurons. [less ▲]

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See detailLettre de Biélorussie
Mouton, Charles ULg

in Revue Générale (1997), (8/9), 79-86

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See detailL'interprétation communautaire de la notion de défendeur défaillant au sens de l'article 27, point 2, de la Convention de Bruxelles
Boularbah, Hakim ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1997)

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See detailEssai d'utilisation du meloxicam (Metacam® Boehringer Ingelheim) chez le pigeon voyageur
Marlier, Didier ULg; Jonckers, Frédéric; Vindevogel, Henri ULg

in Annales de Médecine Vétérinaire (1997), 141

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See detailRoquentin et les types sans importance sociale
Denis, Benoît ULg

in Etudes Françaises (1997), XXXIII(3), 105-119

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See detailLe niveau de lecture à l'entrée du secondaire en Communauté française de Belgique: Des compétences fragiles et si diverses…
Lafontaine, Dominique ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1997), 41-42(129), 161

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See detailMorphological alterations of blood platelets induced by Platelet Activating Factor (PAF) and partial inhibition by Ketoprofen in calves
Bastos da Silva, Miriam; Doizé, Cécile ULg; David, Jean-Louis ULg et al

in Veterinary Research (1997), 28(5 Sep-Oct), 489-502

The influence of platelet activating factor (PAF) was investigated in vivo on the ultrastructure of bovine platelets, and on the platelet count. The effect of an intravenous administration of ketoprofen ... [more ▼]

The influence of platelet activating factor (PAF) was investigated in vivo on the ultrastructure of bovine platelets, and on the platelet count. The effect of an intravenous administration of ketoprofen (a non-steroidal anti-inflammatory drug) pretreatment followed by PAF infusion was also observed in a group of six healthy male Friesian calves. PAF infusion alone caused a moderate thrombocytopenia, which peaked one minute post challenge and returned to levels not significantly different from control after 30 min. Electron microscopy revealed that after PAF infusion, platelets lost their lentiform shape and became irregular, with many pseudopods. Their microtubules became impossible to distinguish. The numbers of alpha granules and dense bodies were significantly decreased. Glycogen particles became rare or even disappeared. Giant platelets occasionally appeared. The Golgi apparatus was more often visible and the number of mitochondria was significantly increased. Ketoprofen pretreatment lowered PAF-induced thrombocytopenia and decrease in the number of dense bodies. Under these conditions, the Golgi apparatus was rarely visible and giant platelets were not observed. These results showed that the morphological ultrastructure of blood platelets in bovines were modified following PAF infusion and that ketoprofen pretreatment before PAF infusion provided partial protection, limiting the extent of the morphological alterations and maintaining a normal platelet count [less ▲]

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See detailDivergence of function and regulation of class B floral organ identity genes.
Samach, A.; Kohalmi, S. E.; Motte, Patrick ULg et al

in Plant Cell (1997), 9(4), 559-70

Regulatory mechanisms controlling basic aspects of floral morphogenesis seem to be highly conserved among plant species. The class B organ identity genes, which are required to establish the identity of ... [more ▼]

Regulatory mechanisms controlling basic aspects of floral morphogenesis seem to be highly conserved among plant species. The class B organ identity genes, which are required to establish the identity of organs in the second (petals) and third (stamens) floral whorls, are a good example of such conservation. This work compares the function of two similar class B genes in the same genetic background. The DEFICIENS (DEF) gene from Antirrhinum, including its promoter, was transformed into Arabidopsis and compared in function and expression with the Arabidopsis class B genes APETALA3 (AP3) and PISTILLATA (PI). The DEF gene was expressed in the second, third, and fourth whorls, as was PI. Functionally, DEF could replace AP3 in making petals and stamens. The DEF gene's AP3-like function and PI-like expression caused transformation of fourth-whorl carpels to stamens. Like AP3, all aspects of DEF function in Arabidopsis required a functional PI protein. Surprisingly, DEF could not replace the AP3 protein in properly maintaining AP3 transcripts (autoregulation). Our data allow us to revise the current model for class B autoregulation and propose a hypothesis for the evolution of class B gene expression in dicotyledonous plants. [less ▲]

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See detailPrevention and treatment of postmenopausal osteoporosis. National consensus of the Belgian Bone Club"
Kaufman, JM; Devogelaer, JP; Raeman, F et al

in Clinical Rheumatology (1997), 16(4), 343-345

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See detailThe Degradation Of L-Tyrosine To Phenol And Benzoate In Pig Manure - The Role Of 4-Hydroxy-Benzoate
Antoine, P.; Taillieu, X.; Thonart, Philippe ULg

in Applied Biochemistry and Biotechnology (1997), 63-5

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See detailNew Primers For The Polymerase Chain Amplification Of Cpdna Intergenic Spacers In Phaseolus Phylogeny
Fofana, B.; Harvengt, L.; Baudoin, Jean-Pierre ULg et al

in Belgian Journal of Botany (1997), 129(2),

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See detailEvaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways
Duvivier, Dominique Hannia; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Veterinary Research (1997), 28(6), 557-564

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M ... [more ▼]

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M). The in vitro inhalation study was performed using the cascade impaction method (Andersen Sampler) adapted to imitate nasal breathing. The amount of ipratropium found in the device, the artificial upper airways and the six stages of the Andersen Sampler was measured using high precision liquid chromatography. Stage 1 of the Andersen Sampler was considered to be the respirable fraction and stages 2 to 6 to be the non-respirable fraction. It was concluded that the theoretical respirable fraction of ipratropium obtained after DPI through Inhalator M was influenced by relative air humidity, air flow and the position of the device, whereas the number of successive inspirations and the duration of inspiration did not affect this fraction of the drug. [less ▲]

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See detailEndocrinologie et immunologie au service des productions animales.
Portetelle, Daniel ULg; Burny, A.; Renaville, Robert ULg

in Agricontact (1997), (290),

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See detailLa violence dans les stades de football
Comeron, Manuel ULg

in Revue Générale (1997), (2), 21-30

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See detailOxidation of allylselenides with the Sharpless AD-reagents
Krief, Alain; Colaux, Catherine ULg; Dumont, willy

in Tetrahedron Letters (1997), 38(18), 3315-3318

Allylselenides are efficiently oxidized by AD-mix reagents. Oxidation takes chemoselectively place on the selenium atom of allylselenides bearing a methylseleno or a phenylseleno moiety, but ... [more ▼]

Allylselenides are efficiently oxidized by AD-mix reagents. Oxidation takes chemoselectively place on the selenium atom of allylselenides bearing a methylseleno or a phenylseleno moiety, but chemoselectively occurs on the C,C double bond of the corresponding o-nitrophenyl derivatives. [less ▲]

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Vaisseaux, Coeur, Poumons (1997), 2

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See detailLa nouvelle réglementation du concordat judiciaire
Thirion, Nicolas ULg

in Actualités du Droit (1997), (3), 379-420

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See detailDrug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments.
Scheen, André ULg

in Drugs (1997), 54(3), 355-68

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various ... [more ▼]

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various pharmacological approaches to improving glucose homeostasis, but those currently used in clinical practice either do not succeed in restoring normoglycaemia in most patients or fail after a variable period of time. For glycaemic regulation, 4 classes of drugs are currently available: sulphonylureas, biguanides (metformin), alpha-glucosidase inhibitors (acarbose) and insulin, each of which has a different mode and site of action. These standard pharmacological treatments may be used individually for certain types of patients, or may be combined in a stepwise fashion to provide more ideal glycaemic control for most patients. Adjunct treatments comprise a few pharmacological approaches which may help to improve glycaemic control by correcting some abnormalities frequently associated with NIDDM, such as obesity (serotoninergic anorectic agents) and hyperlipidaemia (benfluorex). There is intensive pharmaceutical research to find new drugs able to stimulate insulin secretion (new sulphonylurea or nonsulphonylurea derivatives, glucagon-like peptide-1), improve insulin action (thiazolidinediones, lipid interfering agents, glucagon antagonists, vanadium compounds) or reduce carbohydrate absorption (miglitol, amylin analogues, glucagon-like peptide-1). Further studies should demonstrate the superiority of these new compounds over the standard antidiabetic agents as well as their optimal mode of administration, alone or in combination with currently available drugs. [less ▲]

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See detailA moderate transfusion regimen may reduce iron loading in beta-thalassemia major without producing excessive expansion of erythropoiesis.
Cazzola, M.; Borgna-Pignatti, C.; Locatelli, F. et al

in Transfusion (1997), 37(2), 135-40

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is ... [more ▼]

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is frequently associated with manifestations of transfusion iron overload, despite regular chelation therapy with subcutaneous desferoxamine. STUDY DESIGN AND METHODS: To verify whether a transfusion regimen with a target pretransfusion hemoglobin level between 9 and 10 g per dL can allow a significant reduction in blood consumption, while still effectively suppressing erythropoiesis, the records were reviewed of 32 beta-thalassemia major patients, who were maintained at a pretransfusion hemoglobin of 11.3 +/- 0.5 g per dL between 1981 and 1986. These patients were switched at the beginning of 1987 to a transfusion regimen with pretransfusion hemoglobin of 9.4 +/- 0.4 g per dL. The degree of erythroid marrow activity was evaluated in these patients and in 32 subjects with beta-thalassemia intermedia through the simple measurement of serum transferrin receptor. RESULTS: After the adoption of the moderate transfusion regimen, transfusion requirements decreased from 137 +/- 26 to 104 +/- 23 mL per kg per year of red cells (p < 0.0001), and mean serum ferritin decreased from 2448 +/- 1515 to 1187 +/- 816 micrograms per L (p < 0.0001), with one-half of patients achieving serum ferritin levels lower than 1000 micrograms per L. The proportion of patients having spontaneous pubertal development increased significantly (p < 0.01), as a result of less iron-related gonadotropin insufficiency. At the lower pretransfusion hemoglobin, erythroid marrow activity did not exceed two to three times normal levels in most subjects. CONCLUSION: As compared with hypertransfusion, moderate transfusion may allow more effective prevention of iron loading, with higher likelihood of spontaneous pubertal development and without producing excessive expansion of erythropoiesis. [less ▲]

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See detailActivation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells
Legrand-Poels, Sylvie ULg; Maniglia, Salvator; Boelaert, J. R. et al

in Biochemical Pharmacology (1997)

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See detailAre Amphipathic Asymmetric Peptides Ubiquitous Structures For Membrane Destabilisation?
Rahman, M.; Lins, Laurence ULg; Thomas, Annick ULg et al

in Journal of Molecular Modeling (1997), 3(5), 203-215

The fusion of some viruses (SIV, BLV, etc) to host cells implicates short fragments of the fusion protein that are asymmetric amphipathic helices in molecular modelling. The tilted orientation of these ... [more ▼]

The fusion of some viruses (SIV, BLV, etc) to host cells implicates short fragments of the fusion protein that are asymmetric amphipathic helices in molecular modelling. The tilted orientation of these fragments at a water/lipid interface is directly related to their fusogenic capacity. On this basis, we have searched for fragments of sequences corresponding to “viral fusion peptides” in other proteins. We have developed a strategy to detect them from primary sequences. Many candidates were detected, especially in transmembrane areas of membranous proteins, in signal sequences and in globular proteins. We suggest that they are involved in the dynamics of lipid-protein interactions. [less ▲]

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See detailSIME: A hybrid approach to fast transient stability assessment and contingency selection
Zhang, Ywee; Wehenkel, Louis ULg; Rousseaux, Patricia ULg et al

in International Journal of Electrical Power & Energy Systems (1997), 19(3), 195-208

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME ... [more ▼]

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME for Single Machine Equivalent. SIME relies on a particular direct method coupled with time-domain programs so as to combine the strengths of both, namely: the flexibility with respect to power system modelling of time-domain methods; the speed and richer information of the direct method. This paper lays the foundations of SIME, devises appropriate techniques for transient stability assessment per se and for contingency screening, and finally integrates these two techniques in a fully general function, i.e. able to comply with any power system modelling and stability scenario, and to assess any type of stability limits (critical clearing times or power limits). Throughout, real-world examples illustrate the proposed techniques and highlight their performances. [less ▲]

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See detailThe 118-135 Peptide Lot The Human Prion Protein Forms Amyloid Fibrils And Induces Liposome Fusion
Pillot, T.; Lins, Laurence ULg; Goethals, M. et al

in Journal of Molecular Biology (1997), 274(3), 381-93

The prion protein (PrPC) is a glycoprotein of unknown function normally found at the surface of neurons and of glial cells. It is involved in diseases such as bovine spongiform encephalopathy, and ... [more ▼]

The prion protein (PrPC) is a glycoprotein of unknown function normally found at the surface of neurons and of glial cells. It is involved in diseases such as bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in the human, where PrPC is converted into an altered form (termed PrPSc). PrPSc is highly resistant towards proteolytic degradation and accumulates in the central nervous system of affected individuals. By analogy with the pathological events occuring during the development of Alzheimer's disease, controverses still exist regarding the relationship between amyloidogenesis, prion aggregation and neuronal loss. To unravel the mechanism of PrP neurotoxicity and understand the interaction of PrP with cellular membranes, a series of natural and variant peptides spanning residues 118 to 135 of PrP was synthesized. The potential of these peptides to induce fusion of unilamellar lipid vesicles was investigated. According to computer modeling calculations, the 120 to 133 domain of PrP is predicted to be a tilted lipid-associating peptide, and to insert in a oblique way into a lipid bilayer through its N-terminal end. In addition to amyloidogenic properties exhibited in vitro by these peptides, peptide-induced vesicle fusion was demonstrated by several techniques, including lipid- and core-mixing assays. Elongation of the 120 to 133 peptide towards the N- and C-terminal ends of the PrP sequence showed that the 118 to 135 PrP peptide has maximal fusogenic properties, while the variant peptides had no effect. Due to their high hydrophobicity, all peptides tested were able to interact with liposomes to induce leakage of encapsulated calcein. We demonstrate also that the propensity of the peptides to fold as an alpha-helix increases their fusogenic activity, thus accounting for the maximal fusogenic activity of the most stable helix at residues 118 to 135. These data suggest that, by analogy with the C-terminal domain of the beta-amyloid peptide, the fusogenic properties exhibited by the prion peptides might contribute to the neurotoxicity of these peptides by destabilizing cellular membranes. [less ▲]

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See detailEtude histologique de lésions subcliniques de la lèvre latérale du talus chez le cheval
Yousfi, S.; Gabriel, Annick ULg; Maroit, V. et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailRoles of circadian rhythmicity and sleep in human glucose regulation.
Van Cauter, E.; Polonsky, K. S.; Scheen, André ULg

in Endocrine Reviews (1997), 18(5), 716-38

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See detailA la mémoire de Daniel P. Bobon, Mafhoud Boucebci, Amadeo Sanchez Blanque, Jean Mirel
Mormont, Christian ULg

in Acta Psychiatrica Belgica (1997), 97(Suppl. 1), 2-7

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See detailUne masse cervicale de diagnostic souvent errone: le chemodectome carotidien.
Defraigne, Jean-Olivier ULg; Antoine, Paul ULg; SakalihasanN, Natzi ULg et al

in Revue Médicale de Liège (1997), 52(7), 485-97

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See detailOptimizing the treatment of Paget’s disease of bone
Reginster, Jean-Yves ULg; Gennari, C; Hosking, DJ et al

in Revue du Rhumatisme (English ed.) (1997), 64(4), 207-209

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See detail(Meth)acrylates pseudo-living radical polymerization in the presence of transition metal complexes: the Kharasch reaction revisited
Granel, Claude; Moineau, George; Lecomte, Philippe ULg et al

in Polymer Preprints (1997), 38(1), 450-451

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See detailThree new species of Opegraphaceae (Lichens) from the Namib desert
Egea, J.M.; Sérusiaux, Emmanuël ULg; Torrente, Pilar et al

in Mycotaxon (1997), 61

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See detailLe maintien des droits aux prestations de santé lors d'une séparation de fait ou de corps
Michiels, Olivier ULg

in Divorce : Actualité Juridique, Sociale et Fiscale (1997)

L'article examine la question du maintien des droits aux prestations de santé lors d'une séparation de corps ou d'une séparation de fait.

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See detailA cinnabar local order in liquid II-VI compounds
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Ceolin, R. et al

in Physica B: Condensed Matter (1997)

A short wavelength (lambda=0.7 Aring) neutron scattering experiment has been performed on the II-VI compounds HgS, HgSe and Zn xHg 1-xTe. Liquid HgS can be viewed as a distortion of the blende structure ... [more ▼]

A short wavelength (lambda=0.7 Aring) neutron scattering experiment has been performed on the II-VI compounds HgS, HgSe and Zn xHg 1-xTe. Liquid HgS can be viewed as a distortion of the blende structure; we show that this distortion decreases gradually with temperature. For Zn xHg 1-xTe, we show that the transition between the six coordinated HgTe liquid and the four coordinated ZnTe liquid is not continuous, the intermediate phase being a deformed cinnabar one [less ▲]

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See detailUse of the alpha parameter method to calculate matrix corrections for infinitely thick targets (TTPIXE) with two different incident beam energies
Delbrouck Habaru, J.; Roelandts, I.; Strivay, David ULg et al

in Nuclear Instruments & Methods in Physics Research Section B (1997), 129(1), 92-100

The alpha parameter correction method for calculating matrix effects in PIXE data does not require a priori knowledge of the major element composition of the matrix but implies the determination of a so ... [more ▼]

The alpha parameter correction method for calculating matrix effects in PIXE data does not require a priori knowledge of the major element composition of the matrix but implies the determination of a so-called alpha parameter linking two independent phenomena: X-ray absorption and proton energy loss. The method extrapolated to the infinitely thick targets (TTPIXE) has been previously studied using two PIXE measurements in two different geometric configurations. The present Study deals with the possibility of using pairs of PIXE measurements at two different energies to obtain the alpha corresponding to thick samples (TTPIXE). The experimental conditions and error minimization problems are discussed. General tables allowing an easy use of the method are presented. [less ▲]

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See detailLe concept de qualité de vie
Etienne, Anne-Marie ULg; Fontaine, Ovide ULg

in Revue Francophone de Clinique Comportementale et Cognitive (1997), II(3), 16-25

Les auteurs examinent les problèmes rencontrés pour définir et mesurer la qualité de vie. Il se dégage des multiples définitions un ensemble de propriétés et de caractéristiques telles que la ... [more ▼]

Les auteurs examinent les problèmes rencontrés pour définir et mesurer la qualité de vie. Il se dégage des multiples définitions un ensemble de propriétés et de caractéristiques telles que la multifactorialité, l'auto-évaluation, la variabilité temporelle et la subjectivité. De plus, l'étude comparative des multiples outils existants devrait permettre d'affiner leur spécificité et donc aider à la compréhension du concept... [less ▲]

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See detailMolecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Biochemical and Biophysical Research Communications (1997), 237

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding ... [more ▼]

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding proteins are displayed on mature sperm cells. In each mammalian species, a restricted subset of olfactory receptors is expressed in male germ cells and displays a pattern of expression suggestive of their potential implication in the control of sperm physiology. In addition to the cDNA fragments available previously, we now report the molecular cloning of two olfactory receptor cDNAs from a human testis library. Five olfactory receptor genes expressed in germ cells were localized in the human genome by radiation hybrid mapping. Three of the genes map to the short arm of chromosome 19 (19p13.1-19p31.3), one to chromosome 11 (11q22.1-22.3), and one to chromosome 17 (17q21-22). The former two localizations fall within clusters previously identified for members of the putative olfactory receptor gene family expressed in olfactory mucosa. Similarly, sequence analysis has revealed that these testicular genes share no distinctive structural features from the other, non-testicular, members of the family. The expression of a subset of olfactory receptor genes in the male germ line is therefore not correlated to their belonging to a specific structural subgroup, or to a specific gene cluster or chromosomal segment [less ▲]

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See detailLes moyens de se prémunir contre la défaillance de ses cocontractants
Georges, Frédéric ULg

in Actualités du Droit (1997)

Cette contribution commentait l'impact de la réforme de 1997 du droit de l'insolvabilité sur les droits des créanciers

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See detailRégime et tactique alimentaires de la loutre (Lutra lutra) dans le Massif Central
Libois, Roland ULg

in Vie et milieu (1997), 47(1), 33-45

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback ... [more ▼]

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback, gudgeon and minnow) are the most numerous items in the diet: they account for more than 50% of the 3,148 identified preys. However, when expressed in relative biomass, their importance falls down (8 %). In fact, the brown trout, large cyprinid fish, birds and mammals make up the bulk of the diet. We found strong differences linked to the general habitat types and also seasonal ones. Frogs are mainly preyed upon during the spring whereas the snakes are exclusively taken in the summer and autumn months. Gudgeon and insects are also mainly summer and autumn preys. Perch and large cyprinid fish remais are more frequent during winter and even spring. The present results confirm the opportunistic way of predation of the otter and the fact that its hunting takes place more on the bottom and along the river banks than in the open water. [less ▲]

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See detailA one-nucleotide difference in a cAMP and phorbol ester response element leads to differential regulation of the human chorionic somatomammotropin A and B gene transcription
Oury, Cécile ULg; Alsat, E.; Jacquemin, P. et al

in Journal of Molecular Endocrinology (1997), 18(2), 87-99

Human chorionic somatomammotropin (hCS) is encoded by two highly related genes, hCS-A and hCS-B, located in the hGH/hCS gene locus. Both genes are expressed in the syncytiotrophoblast layer of the ... [more ▼]

Human chorionic somatomammotropin (hCS) is encoded by two highly related genes, hCS-A and hCS-B, located in the hGH/hCS gene locus. Both genes are expressed in the syncytiotrophoblast layer of the placenta and hCS release from trophoblast cells is known to be increased by cAMP and phorbol esters. However, it remains unclear whether this regulation acts at the level of hCS gene expression or secretion and whether both genes are affected. We examined the effects of cAMP and phorbol 12-myristate 13-acetate (PMA) on the transcription of the hCS-A and hCS-B genes. Transient expression experiments revealed a 7 bp cAMP- and PMA-responsive element (CRElhCS-A) spanning nucleotides-1102 to -1096 upstream of the hCS-A gene. In contrast, the homologous sequence upstream of hCS-B (CRElhCS-B), differing from CRElhCS-A by a single substitution, shows little or no response to cAMP. In band-shift assays, the CRElhCS-A oligonucleotide was shown to bind two factors related to CREBP and AP-1, whereas CRElhCS-B only competes for one of these complexes. Finally, Southwestern analysis revealed that the CRElhCS-A element binds two ubiquitous proteins of 100 kDa and 47 kDa respectively, whereas CRElhCS-B interacts only with the 47 kDa protein. Taken together, these results suggest that a 47 kDa protein binding to the CRElhCS-A and CRElhCS-B elements is involved in the PMA response of the hCS-A and hCS-B genes, and a 100 kDa protein plays a crucial role in cAMP regulation of the hCS-A gene. [less ▲]

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See detailUne chambre noire pour l’analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1997), 33

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See detailNeurophysines et cancer pulmonaire a petites cellules
Pirard, Françoise; Pequeux, Christel ULg; Hendrick, J. C. et al

in Revue Médicale de Liège (1997), 52(1), 22-6

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See detailGuillaume de Savoie. Un monstrum spirituale et belua multorum capitum sur le trône de saint Lambert ?
Marchandisse, Alain ULg

in Bulletin de la Société Royale Le Vieux-Liège (1997), 13

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See detailRelationship of human follicular diameter with oocyte fertilization and development after in-vitro fertilization or intracytoplasmic sperm injection.
Ectors, Fabien ULg; Vanderzwalmen, P.; Van Hoeck, J. et al

in Human Reproduction (1997), 12(9), 2002-2005

The aim of this work was to evaluate the relationship between follicular size at the time of oocyte retrieval, and the subsequent oocyte competence to be fertilized and to develop in vitro. All the ... [more ▼]

The aim of this work was to evaluate the relationship between follicular size at the time of oocyte retrieval, and the subsequent oocyte competence to be fertilized and to develop in vitro. All the obtained oocytes were classified according to the corresponding volume of aspirated follicular fluid. Aspirated volume of follicular fluid <2 ml corresponded to a follicular diameter <16 mm and constituted the small size group. Volume of follicular fluid from 2 to 6 ml corresponded to a diameter from 16 to 23 mm and constituted the medium size group. The large size group contained follicles with diameter >23 mm and corresponded to an aspirated volume of follicular fluid of >6 ml. A progressive and significant increase in the rates of oocytes with a first polar body was observed from the small size group to the other groups and from the medium to the large size group: 75.3, 85.9 and 95.3% respectively. After classical in-vitro fertilization (IVF), significantly better rates of fertilization and development were obtained in the medium size group compared to the two other groups. Moreover, a positive relationship was observed between follicular diameter and rates of embryos scored as 'good' when oocytes were fertilized by intracytoplasmic sperm injection (ICSI). These results demonstrated that follicular size is positively related to the oocyte ability to be fertilized and to develop. Although oocytes from small follicles gave lower percentages of development probably due to partial oocyte incompetence, they allowed an increase in the total number of embryos scored as 'good'. [less ▲]

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See detailAnomalously large Born effective charges in cubic WO3
Detraux, F.; Ghosez, Philippe ULg; Gonze, X.

in Physical Review. B : Condensed Matter (1997), 56(3), 983-985

Within density-functional theory, we compute the Born effective charges of tungsten trioxyde in its reference cubic phase (defect-perovskite structure). For the tungsten atom, the effective charge tensor ... [more ▼]

Within density-functional theory, we compute the Born effective charges of tungsten trioxyde in its reference cubic phase (defect-perovskite structure). For the tungsten atom, the effective charge tensor is isotropic, with Z(W)*=+12.51. For the oxygen atoms, the two independent components of the tensor, corresponding, respectively, to a displacement of the atom parallel or perpendicular to the W-O bond, have the values Z(O parallel to)* = -9.13 and Z(O perpendicular to)* = -1.68. Z(W)* and Z(O parallel to)* are anomalously large with respect to the nominal ionic charges (+6 on W and -2 on O), but compatible with the Born effective charges found in related ABO(3)-perovskite compounds. [less ▲]

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See detailImprovement of inland navigation in developping countries: the training center of Palembang (Sumatra, Indonesia), an example of transfer of technology through education
Marchal, Jean ULg

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (1997), Nouvelle Série 42(4)(1er trimestre), 10

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See detailPEGASE, une méthodologie et un outil de simulation prévisionnelle pour la gestion de la qualité des eaux de surface
Smitz, Joseph ULg; Everbecq, Etienne ULg; Deliège, Jean-François ULg et al

in Tribune de l'Eau (La) (1997), 50/4(588), 73-82

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle ... [more ▼]

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle la qualité des eaux des rivières en fonction des rejets et apports de pollution. PEGASE est un outil opérationnel permettant d’orienter les choix des opérateurs publics et privés en matière de gestion des eaux de surface à l’échelle des bassins versants [less ▲]

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See detailAttitude des élèves face à l'école et au cours d'éducation physique, âge et retard scolaire
Piéron, Maurice; Delfosse, Catherine; Ledent, Maryse et al

in Revue de l'Education Physique (1997), 37(1), 31-41

Le terme motivation fait partie du langage habituel des psychologues, des enseignants, des sportifs,... Nous pourrions continuer cette liste sans parvenir à lui donner un caractère exhaustif. Parfois ... [more ▼]

Le terme motivation fait partie du langage habituel des psychologues, des enseignants, des sportifs,... Nous pourrions continuer cette liste sans parvenir à lui donner un caractère exhaustif. Parfois utilisé de manière abusive, ce concept présente néanmoins des aspects théoriques et pratiques fondamentaux. A la notion de motivation, on associe très fréquemment celle d'attitude. Toutes deux sont définies en référence à l'affect, c'est-à-dire à une impression d'attraction ou de répulsion vis-à-vis d'un objet déterminé. ... [less ▲]

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See detailMecanisme de croissance et de rupture des anevrysmes de l'aorte abdominale.
Limet, Raymond ULg; SakalihasanN, Natzi ULg; Lapiere, C. M.

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1997), 152(7-9), 295-302302-3

The relationship between atherosclerosis and abdominal aortic aneurysm development is well known. Atherosclerosis cannot explain the whole mechanism. Genetic characters of mechanisms leading to abdominal ... [more ▼]

The relationship between atherosclerosis and abdominal aortic aneurysm development is well known. Atherosclerosis cannot explain the whole mechanism. Genetic characters of mechanisms leading to abdominal aortic development is obvious from this study and others. Our study evidences an increased metalloproteases activity in aortic wall proportionally to the size of the abdominal aortic aneurysm. A decrease of aortic wall elastin is evidenced proportionally to the AAA size. Extractable collagen is significantly increased in the aortic wall of patients operated on for aortic rupture. [less ▲]

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See detailThéorie de l'approche hydrogéologique des écoulements et transports en zone partiellement saturée
Dassargues, Alain ULg

in Annales de la Société Géologique de Belgique (1997), 119(1), 71-89

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See detailNanoindentation and scanning force microscopy as a novel method for the characterization of tribological transfer films
Randall, N. X.; Bozet, Jean-Luc ULg

in Wear (1997), 212(1), 18-24

In conventional pin-on-disk testing of the tribological characteristics of two different materials in sliding contact, the main parameters of interest are notably the friction and wear properties of the ... [more ▼]

In conventional pin-on-disk testing of the tribological characteristics of two different materials in sliding contact, the main parameters of interest are notably the friction and wear properties of the material pair. However, when two bodies consisting of hard and soft materials respectively are subjected to such testing, the appearance of a transfer film, or third body, which can be a composite mixture of the two, is often observed. Until now the characterization of transfer films in terms of their mechanical properties has been hampered by their nonhomogeneous distribution across a tested surface, their small size, low thickness and the difficulty in accurately positioning a test probe such that the film properties can be measured independently from those of the substrate. In this paper a new method is introduced, consisting of nanoindentation and scanning force microscopy (SFM), which is capable of highly localized indentation testing of a specified sample site with high resolution imaging of the area prior to and after indentation. In this way the hardness and modulus of a transfer film can be obtained, as well as valuable surface topographical information concerning the material response to the indentation. Measurements are presented for the material pair A286/polyimide after testing on a pin-on-disk tribometer in ambient air and liquid nitrogen. Distinct variations in hardness between the transfer films and their contacting bodies have een observed and correlated to the wear behaviour and testing environment. (C) 1997 Elsevier Science S.A. [less ▲]

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See detailLa table des lois de Dune : exercice structuré de créativité intellectuelle en groupe
Broonen, Jean-Paul ULg; Bovy, Michel

in Cahiers Internationaux de Psychologie Sociale (1997), 34(2), 100-109

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See detailQuantitative ultrasound techniques for the assessment of osteoporosis : Expert agreement on current status
Glüer, CC; Reginster, Jean-Yves ULg

in Journal of Bone and Mineral Research (1997), 12(8), 1280-1288

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See detailNon-insulin-dependent diabetes mellitus in the elderly.
Scheen, André ULg

in Bailliere's Clinical Endocrinology and Metabolism (1997), 11(2), 389-406

The prevalence of non-insulin-dependent diabetes mellitus dramatically increases with age. Older diabetic subjects have an increased frequency of complications from diabetes compared with their younger ... [more ▼]

The prevalence of non-insulin-dependent diabetes mellitus dramatically increases with age. Older diabetic subjects have an increased frequency of complications from diabetes compared with their younger counterparts and higher morbidity and mortality rates compared with age-matched non-diabetic controls. Elderly patients with diabetes are generally treated following the same approach as in younger patients: dietary therapy first, followed by oral hypoglycaemic agents and ultimately insulin. However, several specificities should be pointed out. Changes associated with ageing may affect the pharmacokinetics and pharmacodynamics of both sulphonylureas (increasing the risk of severe hypoglycaemia) and biguanides (increasing the risk of lactic acidosis). The best insulin regimen in old age is not known, but a twice-daily injection of a pre-mixed insulin preparation is usually recommended. Goals of therapy must be realistic and not cause disabling side-effects. The general practitioner plays a crucial role in the care of elderly diabetic patients, but access to a multidisciplinary specialized team may be necessary. [less ▲]

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See detailAdvantages of Inferior Vena Caval Flow Preservation in Combined Transplantation of the Liver and Heart
Detry, Olivier ULg; Honore, Pierre ULg; Meurisse, Michel ULg et al

in Transplant International (1997), 10(2), 150-1

Only a few cases of combined liver and heart transplantation have been reported in the literature, and no standard surgical procedure has yet been established. We report the successful transplantation of ... [more ▼]

Only a few cases of combined liver and heart transplantation have been reported in the literature, and no standard surgical procedure has yet been established. We report the successful transplantation of both liver and heart in a 28-year-old patient suffering from homozygous beta-thalassemia. We used Belghiti's technique of inferior vena caval flow preservation for liver transplantation, which avoids inferior vena cava occlusion by a side-to-side caval anastomosis. Applied to combined liver and heart transplantation, preservation of caval flow during liver transplantation may allow early discontinuation of cardiopulmonary bypass and, thus, minimize the general consequences of prolonged bypass. [less ▲]

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See detailMeasurement of the power output during the acceleration phase of all-put arm cranking exercise
Vanderthommen, Marc ULg; Francaux, Marc; Johnson, D. et al

in International Journal of Sports Medicine (1997), 18

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Percentile (1997), 2

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See detailAbsolute Configuration Of The Isopyoverdin Chromophore
Michalke, R.; Taraz, K.; Budzikiewicz, H. et al

in Zeitschrift Fur Naturforschung C-A Journal of Biosciences (1997), 52(7-8), 549-550

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See detailRetrieval of ozone vertical column amounts from ground-based high resolution infrared solar spectra
Hamdouni, A.; Barbe, Alain; Demoulin, Philippe ULg et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (1997), 57(1), 11-22

Good infrared spectral regions to retrieve accurately the vertical column amount of ozone from ground observations are proposed. Their selection was based on studies of the influence of spectroscopic ... [more ▼]

Good infrared spectral regions to retrieve accurately the vertical column amount of ozone from ground observations are proposed. Their selection was based on studies of the influence of spectroscopic (frequencies, half-widths, intensities) as well as geophysical parameters (volume mixing ratios, temperature profiles) with a particular attention for temperature. The results, obtained in three different spectral regions, with a realistic T-profile are very consistent. [less ▲]

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See detailModulation of lung inflammation in the control of bovine respiratory disease
Van de Weerdt, ML; Lekeux, Pierre ULg

in Bovine Practitioner (1997), 31.1

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible ... [more ▼]

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible preventive treatments will not be discussed in this review. [less ▲]

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See detailGlobal adaptive stabilization of cascade nonlinear systems
Jankovic, M.; Sepulchre, Rodolphe ULg; Kokotovic, Petar V.

in Automatica (1997), 33(2), 263-368

An adaptive controller is developed for a class of nonlinear systems for which other approaches (e.g. backstepping) may fail to be applicable. The new design employs feedback passivation and an explicit ... [more ▼]

An adaptive controller is developed for a class of nonlinear systems for which other approaches (e.g. backstepping) may fail to be applicable. The new design employs feedback passivation and an explicit construction of a Lyapunov function for the zero dynamics with respect to a relative degree 1 output. As an illustration a longstanding "nonlinear benchmark problem" is solved. [less ▲]

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See detailFatal Massive Liver Steatosis. A Clinicopathological Case Report
de Leval, Laurence ULg; Lambermont, Bernard ULg; D'Orio, Vincenzo ULg et al

in Acta Gastro-Enterologica Belgica (1997), 60(2, Apr-Jun), 180-183

Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman ... [more ▼]

Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman under anticonvulsivant therapy and with medications for a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) who presented with rapidly progressive cholestasis and hepatocellular failure is reported. Massive macro- and micro-vesicular hepatic steatosis was diagnosed at autopsy. The authors review the clinico-pathological features associated with this condition, and causal factors possibly implicated in this case are discussed in regard with currently considered pathophysiological mechanisms. [less ▲]

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See detailEtude radiographique des affections ostéo-articulaires juvéniles (AOAJ) chez des chevaux de races françaises âgés de 3 ans : présentation globale des résultats sur 761 sujets.
Denoix, JM; Valette, JP; Robert, C et al

in Bulletin de la Société Vétérinaire Pratique de France (1997)

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See detailIntellectuels malgré eux
Denis, Benoît ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1997), (79-81), 49-52

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See detailIntoxications par le Temik® chez les animaux domestiques et sauvages : un problème alarmant en Wallonie
Delaunois, Annie; Lessire, Françoise ULg; Ansay, M. et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailBiomechanical assessment of the transversalis fascia and rectus abdominis aponeurosis in inguinal herniation - Preliminary results
PANS, Alain ULg; Pierard, Gérald ULg; Albert, Adelin ULg et al

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (1997), 1

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See detailComparison of results of carotid artery surgery after either direct closure or use of a vein patch.
Desiron, Quentin ULg; Detry, Olivier ULg; Van Damme, Hendrik ULg et al

in Cardiovascular Surgery (1997), 5(3), 295-303

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting ... [more ▼]

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting of saphenous vein bypass (n = 29) and eversion endarterectomy (n = 85), 2157 open endarterectomies were performed. They were closed either directly (n = 837) or using a vein patch (n = 1320). The combined mortality-major neurological morbidity rate was 1.7%, i.e. 1% mortality (0.2% neurological) and 0.7% permanent neurological morbidity (0.5% ipsilateral to the operated artery). Early symptomatic internal carotid thrombosis was documented in six cases (four following direct closure and two after vein patching). A total of 827 carotid arteries were followed up by duplex scanning on an annual basis (244 direct closure and 583 vein patching). The mean follow-up was 44 months; 69 months for direct closure and 35 months for vein patching. In direct closure, there were 21 stenoses (9%) and 10 occult thromboses (4%); in vein patching carotids, there were 17 stenoses (3%), nine thromboses (1.8%) [corrected] and six pseudoaneurysms (1%). Annual incidence of poor results was 2.4% in direct closure, and 0.87% in vein patching. The only other factor responsible for a significant difference was gender (3.4% in women versus 2.1% in men). In this retrospective study, vein patching appears to be beneficial for the prevention of acute postoperative thrombosis and late stenosis or thrombosis. [less ▲]

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See detailThe Nucleotide Sequence Of Saccharomyces Cerevisiae Chromosome Xv
Dujon, B.; Albermann, K.; Aldea, M. et al

in Nature (1997), 387(6632),

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See detailAppraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines.
Monroe, E. W.; Daly, Adrian ULg; Shalhoub, R. F.

in Journal of Allergy and Clinical Immunology (The) (1997), 99(2), 798-806

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and ... [more ▼]

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and the number of newer drugs available for clinical use is growing. Various methods have been used to assess antihistaminic activity, the most popular of which is the epicutaneous histamine-induced wheal and flare. This test relies on the ability of epicutaneously injected histamine to bring about the wheal and flare, a neurovascular response that involves reflex vasodilation (flare) and local swelling caused by plasma extravasation (wheal). Antihistamines have been compared on the basis of their ability to block the histamine-induced wheal and flare in the skin. Results of these trials have been applied to predict the global antiallergic efficacy of various antihistamines. The review has examined the reliability of suppression of the histamine wheal and flare reaction in the skin to predict an antihistamine's clinical efficacy in two common allergic diseases seasonal allergic rhinitis and chronic idiopathic urticaria. Although histamine is one mediator in the allergic response in the skin and nasal mucosa, many other agents are important modulators of the allergic response. In addition, the major structural and functional differences that exist between the nasal mucosa and the skin affect the type of local response. These manifest themselves as differences between the responses to antigen and histamine challenge in the skin and the nose. The allergic responses in these tissues are not simply the consequence of one chemical but are the result of a cascade of interactions among various cells and mediators. The clinical manifestations of these complex interactions obviously cannot be fully replicated by injection of one chemical mediator, histamine, into the outer layer of the skin. Studies with antihistamines have shown that certain drugs, such as cetirizine, are more suppressive than others (loratadine, terfenadine) in controlling the histamine-induced wheal and flare reaction in the skin. When the clinical efficacy of these medications is compared in clinical trials in seasonal allergic rhinitis and chronic idiopathic urticaria, all are equally efficacious in controlling symptoms. Although the histamine-induced wheal and flare reaction can serve as a useful clinical pharmacologic test to assess dose-response relations for an antihistamine, its lack of correlation with clinical responses among antihistamines indicates that this model should not be used to predict or compare clinical efficacies of antihistamines in seasonal allergic rhinitis and chronic idiopathic urticaria. [less ▲]

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See detailComment j'explore ... le syndrome d'insulinoresistance grace a ses marqueurs biologiques.
Luyckx, Françoise ULg; Scheen, André ULg; Gielen, Jean-Louis ULg et al

in Revue Médicale de Liège (1997), 52(10), 686-91

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See detailMise au point d'une technique de culture in vitro d'embryons immatures de Phaseolus.
Mergeai, Guy ULg; Schmit, V.; Baudoin, Jean-Pierre ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(1),

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See detailSpecific Modulation Of The Fusogenic Properties Of The Alzheimer Beta-Amyloid Peptide By Apolipoprotein E Isoforms
Pillot, T.; Goethals, M.; Vanloo, B. et al

in European Journal of Biochemistry (1997), 243(3), 650-9

C-terminal fragments of the Alzheimer amyloid peptide (amino acids 29-40 and 29-42) have physico-chemical properties related to those of the fusion peptides of viral proteins and they are able to induce ... [more ▼]

C-terminal fragments of the Alzheimer amyloid peptide (amino acids 29-40 and 29-42) have physico-chemical properties related to those of the fusion peptides of viral proteins and they are able to induce the fusion of liposomes in vitro. We proposed that these properties could mediate a direct interaction of the amyloid peptide with cell membranes and account for part of the cytotoxicity of the amyloid peptide. In view of the epidemiologic and biochemical linkages between the pathology of Alzheimer's disease and apolipoprotein E (apoE) polymorphism, we examined the potential interaction between the three common apoE isoforms and the C-terminal fragments of the amyloid peptide. We show that, at low concentration, only apoE2 and apoE3 are potent inhibitors of the amyloid peptide fusogenic and aggregational properties, whereas the apoE4 isoform has no effect. We further show that the protective effect of apoE is mediated by the formation of stable apoE/amyloid peptide complexes, as determined by tryptophan emission fluorescence measurements and by gel electrophoresis. The interaction specificity between apoE2 and apoE3 and the amyloid fragments is demonstrated here, since other apolipoproteins (e.g. apolipoprotein A-I and A-II), with similar amphipathic structures, do not interact with the amyloid C-terminal fragments. Finally, we show that, reciprocally, the amyloid peptide can interact directly with the apoE2 and apoE3 isoforms to decrease or perturb their normal association with lipids. These data suggest that the 29-40 and 29-42 domains of the amyloid peptide could be critical for the amyloid-apoE interaction, and that apoE2 and apoE3 isoforms, but not apoE4, could play a protective role against the formation of amyloid aggregates and/or against their interaction with cellular membranes. [less ▲]

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See detailAbdominal sequelae after pedicled TRAM flap breast reconstruction
PETIT, JY; RIETJENS, M; FERREIRA, M et al

in Plastic and Reconstructive Surgery (1997), 99

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants ... [more ▼]

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants. Although such enthusiasm for the transverse rectus abdominis musculocutaneous (TRAM) flap is justified in what concerns the final cosmetic result of the reconstructed breast, the risk of abdominal sequelae should be explained to the patient. Abdominal scarring, parietal weakness, strength loss, and back pain have been recorded in a series of pedicled TRAM flap reconstructions performed at the Institut Gustave-Roussy before 1991. Cosmetic results of the abdomen were tested by three independent judges on the photographs taken of 132 patients. The global appearance of the abdomen was rated as "natural" in 70 percent of the patients. The umbilical scar was unacceptable in 25 percent and very good or not visible in 21 percent. The lower abdominal scar was rated as "not acceptable" in 35 percent. Abdominal strength was tested among the 38 patients who underwent both preoperative and postoperative muscular testing, of whom 18 had single-pedicled and 20 had bipedicled TRAM flap reconstructions. In the first group, the physiotherapist observed an impairment of function of the upper portion of the rectus abdominis and of the oblique muscle in almost 50 percent. In the second group, the same muscles were more severely impaired (in 60 percent), as well as the function of the lower portion of the rectus (in 15 percent). The percentage of patients complaining of "light back pain" in the 6-month postoperative period was 55 percent in the single-pedicle group and 30 percent in the double-pedicle group. However, 20 percent of the bipedicled patients complained of "severe" back pain, while there was none in the single-pedicled group. In conclusion, abdominal sequelae after TRAM flap breast reconstruction should not be underestimated and constitute one of the drawbacks of the technique when it is compared with reconstruction with a prosthesis. [less ▲]

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See detailTrajectoire déviante à la lisière entre adolescence et âge adulte
Gavray, Claire ULg

in Déviance et Société (1997), 21(3), 273-288

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See detailBWGIC guidelines for training and quality control in adult interventional cardiology. Belgian Working Group of Invasive Cardiology.
Legrand, Victor ULg; Vrolix, M.; De Bruyne, B. et al

in Acta cardiologica (1997), 52(6), 507-14

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See detailTechniques et indications de la bronchoscopie interventionnelle.
CORHAY, Jean-Louis ULg; Bury, Thierry ULg; Radermecker, Marc ULg et al

in Revue Médicale de Liège (1997), 52(10), 657-65

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See detailSarcoidosis: recognition and treatment guidelines
Kaye, O.; Ribbens, Clio ULg; Kahn, M. F. et al

in BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals & Gene Therapy (1997), 7(6), 441-447

Sarcoidosis is a systemic disorder of unknown aetiology characterised by noncaseating granulomas leading principally to bilateral hilar lymphadenopathies, pulmonary infiltration and skin and eye lesions ... [more ▼]

Sarcoidosis is a systemic disorder of unknown aetiology characterised by noncaseating granulomas leading principally to bilateral hilar lymphadenopathies, pulmonary infiltration and skin and eye lesions. Sarcoidosis may involve other organs, including peripheral lymph nodes, liver, spleen, nervous and musculoskeletal systems, heart, ear, nose and kidney. Although the clinical involvement of liver and heart is relatively uncommon, hepatic and cardiac granulomas are present at autopsy in about 70 to 80% and 25 to 50%, respectively, of patients with this disease. The diagnosis of sarcoidosis includes compatible clinical and/or radiological presentations and histological evidence of noninfectious and noncaseating epitheloid cell granulomas in the absence of other identifiable agents responsible for such histological lesions. Disease course is variable and usually characterised by frequent remissions, but it may become progressive and chronic in a small percentage of patients. The optimal treatment of sarcoidosis remains poorly defined. In patients with progressive pulmonary dysfunction as well as in those with severe extrapulmonary localisations, systemic corticosteroids usually represent the first approach, limited by long term toxicity and frequent relapses after treatment interruption. In the presence of refractory or corticosteroid-dependent forms of the disease, antimalarial drugs or low dosage methotrexate may be used with prolonged benefit. The indications for immunosuppressive agents such as azathioprine, chlorambucil, cyclophosphamide and cyclosporin are uncommon and limited because of potentially serious adverse effects and lack of information on their long term efficacy. In the case of ocular and limited cutaneous manifestations, local corticosteroid therapy may be useful. [less ▲]

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See detailComment j'explore ... Une maladie de Basedow: de la clinique classique au diagnostic radio-immunologique.
Scheen, André ULg

in Revue Médicale de Liège (1997), 52(12), 788-91

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See detailBankfull discharge recurrence interval in gravel bed rivers
Petit, François ULg; Pauquet, A.

in Earth Surface Processes & Landforms (1997)

Bankfull discharge was identified in some 30 gravel-bed rivers representing in total c. 40 gauging stations. The catchment sizes vary from 4km2 to nearly 2700km2. Bankfull discharge values increases with ... [more ▼]

Bankfull discharge was identified in some 30 gravel-bed rivers representing in total c. 40 gauging stations. The catchment sizes vary from 4km2 to nearly 2700km2. Bankfull discharge values increases with basin size. In the case of gravel-bed rivers developed on an impermeable substratum, the following equation emerges: Qb=0·087 A1·044. Bankfull discharge recurrence interval was determined by fitting maximum annual floods (Ta) into Gumbel’s distribution and then using the partial duration series (Tp) in this same distribution. Recurrence interval is below 0·7 years (Tp) for small pebble-bed rivers developed on an impermeable substratum; it reaches 1·1 to 1·5 years when the catchment size of these rivers exceeds 250km2. Rivers incised in the soft schists of the Famenne show larger channel capacity at bankfull stage, a small width/depth ratio and thus higher recurrence intervals (1·4–5·3 years with Ta and 1–4·4 years with Tp). Baseflow-dominated gravel-bed streams and sandy or silty rivers experience less frequent bankfull discharges, with a recurrence interval higher than 2 or even 3 years (Tp). [less ▲]

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See detailPour l’optimisation de la stratégie thérapeutique dans la maladie osseuse de Paget
Reginster, Jean-Yves ULg; Gennari, C; Hosking, DJ et al

in Revue du Rhumatisme (1997), 64(4), 221-223

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See detailA propos de quelques utilisations non conventionnelles de la metformine
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (1997), 55

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See detailDissociations between the processing of proper and common names
Brédart, Serge ULg; Brennen, T.; Valentine, T.

in Cognitive Neuropsychology (1997), 14(2), 209-217

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See detailA primal-dual approach in truss topology optimization
Beekers, M.; Fleury, Claude ULg

in Computers & Structures (1997), 64(1-4), 77-88

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are ... [more ▼]

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are bounds on bar volumes and the satisfaction of equilibrium equations. For a single load case and without bounds on bar volumes, the problem can be written as a linear programming problem with nodal displacements as variables. The addition to the objective function of a quadratic term vanishing at the optimum allows us to use a dual solution scheme. A conjugate gradient method is well suited to maximize the dual function. Several ground structures are introduced. For large networks, those where each node is connected to those situated in a certain vicinity give a good compromise between generating a reasonable number of bars and obtaining a sufficient number of possible directions. Some examples taken from the literature are treated to illustrate the quality of the solution and the influence of initial topology. (C) 1997 Civil-Comp Ltd and Elsevier Science Ltd. [less ▲]

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See detailRectovaginal septum adenomyotic nodules: a series of 500 cases.
Donnez, Jacques; NISOLLE, Michelle ULg; Gillerot, Stépane et al

in British Journal of Obstetrics & Gynaecology (1997), 104(9), 1014-8

OBJECTIVE: Laparoscopic procedure with excision of deep fibrotic endometriotic nodules of the rectovaginal septum and histological study of the lesions. SETTING: An academic teaching hospital ... [more ▼]

OBJECTIVE: Laparoscopic procedure with excision of deep fibrotic endometriotic nodules of the rectovaginal septum and histological study of the lesions. SETTING: An academic teaching hospital. PARTICIPANTS: A series of 500 women undergoing laparoscopy for pelvic pain or infertility. RESULTS: Laparoscopic (n = 497) and laparotomic (n = 3) excision of endometriotic nodules resulted in considerable pain relief. Histologically the rectovaginal nodule was similar to an adenomyoma as it was a circumscribed nodular aggregate of smooth muscle and endometrial glands and stroma. The variations in oestrogen receptor and progesterone receptor content suggested a regulatory mechanism different from that of eutopic endometrium. CONCLUSION: This form of disease should be considered as an entity distinct from peritoneal and ovarian endometriosis, and originating from the Müllerian rests present in the rectovaginal septum. [less ▲]

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See detailOrderly process of sequential cytokine stimulation is required for activation and maximal proliferation of primitive human bone marrow CD34+ hematopoietic progenitor cells residing in G0.
Ladd, A. C.; Pyatt, R.; GOTHOT, André ULg et al

in Blood (1997), 90(2), 658-68

Bone marrow (BM) CD34+ cells residing in the G0 phase of cell cycle may be the most suited candidates for the examination of cell cycle activation and proliferation of primitive hematopoietic progenitor ... [more ▼]

Bone marrow (BM) CD34+ cells residing in the G0 phase of cell cycle may be the most suited candidates for the examination of cell cycle activation and proliferation of primitive hematopoietic progenitor cells (HPCs). We designed a double simultaneous labeling technique using both DNA and RNA staining with Hoechst 33342 and Pyronin Y, respectively, to isolate CD34+ cells residing in G0(G0CD34+). Using long-term BM cultures and limiting dilution analysis, G0CD34+ cells were found to be enriched for primitive HPCs. In vitro proliferation of G0CD34+ cells in response to sequential cytokine stimulation was examined in a two-step assay. In the first step, cells received a primary stimulation consisting of either stem cell factor (SCF), Flt3-ligand (FL), interleukin-3 (IL-3), or IL-6 for 7 days. In the second step, cells from each group were washed and split into four or more groups, each of which was cultured again for another week with one of the four primary cytokines individually, or in combination. Tracking of progeny cells was accomplished by staining cells with PKH2 on day 0 and with PKH26 on day 7. Overall examination of proliferation patterns over 2 weeks showed that cells could progress into four phases of proliferation. Phase I contained cytokine nonresponsive cells that failed to proliferate. Phase II contained cells dividing up to three times within the first 7 days. Phases III and IV consisted of cells dividing up to five divisions and greater than six divisions, respectively, by the end of the 14-day period. Regardless of the cytokine used for primary stimulation, G0CD34+ cells moved only to phase II by day 7, whereas a substantial percentage of cells incubated with SCF or FL remained in phase I. Cells cultured in SCF or FL for the entire 14-day period did not progress beyond phase III but proliferated into phase IV (with <20% of cells remaining in phases I and II) if IL-3, but not IL-6, was substituted for either cytokine on day 7. G0CD34+ cells incubated with IL-3 for 14 days proliferated the most and progressed into phase IV; however, when SCF was substituted on day 7, cells failed to proliferate into phase IV. Most intriguing was a group of cells, many of which were CD34+, detected in cultures initially stimulated with IL-3, which remained as a distinct population, mostly in G0/G1, unable to progress out of phase II regardless of the nature of the second stimulus received on day 7. A small percentage of these cells expressed cyclin E, suggesting that their proliferation arrest may have been mediated by a cyclin-related disruption in cell cycle. These results suggest that a programmed response to sequential cytokine stimulation may be part of a control mechanism required for maintenance of proliferation of primitive HPCs and that unscheduled stimulation of CD34+ cells residing in G0 may result in disruption of cell-cycle regulation. [less ▲]

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See detailAspects économiques du financement des communes
Jurion, Bernard ULg

in Revue de Droit Communal (1997)

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