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See detailInsulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells
l'Allemand, D.; Penhoat, A.; LEBRETHON, Marie-Christine ULg et al

in The Journal of clinical endocrinology and metabolism (1996), 81(11), 3892-7

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation ... [more ▼]

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation. In the present study, we examined the long term effects of IGF-I and -II on human adult adrenal fasciculata-reticularis cells cultured in a chemically defined medium and compared them to the effects of insulin, human GH, and ACTH. Treatment for 3 days with IGF-I or -II at nanomolar concentrations or with insulin at micromolar concentrations slightly increased the production of androstenedione, cortisol, and dehydroepiandrosterone about 1.5-fold over that by control cells. Moreover, the acute steroidogenic response to ACTH of cells pretreated with IGF-I, IGF-II, or insulin was 3- to 6-fold higher than that of control cells. For each hormone, these effects of IGF-I and -II were dose dependent between 0.1-26 nmol/L (1-200 ng/mL). The secretion of androstenedione was more potently stimulated than that of dehydroepiandrosterone and cortisol, and this effect was more clearly yielded by pretreatment with IGF-II than with IGF-I or insulin. Human GH had no effect on these cells. In cells treated with IGF-I or -II, the messenger ribonucleic acid (mRNA) levels of cytochrome P450 17 alpha-hydroxylase and of 3 beta-hydroxysteroid dehydrogenase were increased, and the abundance of ACTH receptor mRNA was also slightly enhanced, but the mRNA of cytochrome P450 cholesterol side-chain cleavage enzyme was unchanged. In conclusion, IGFs enhance the steroidogenesis and ACTH responsiveness of human adrenocortical cells in culture. We speculate, that by this mechanism, IGFs may contribute to clinical states with hyperandrogenemia. [less ▲]

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See detailGranuloma tuberculoide post-herpético en un paciente con leucemia linfocítica crónica
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Medicina Cutanea Ibero-Latino-Americana (1996), 24

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See detailMort mitotique ou mort apoptotique par irradiation : Même combat ?
Coucke, Philippe ULg; ZOUHAIR

in Médecine et Hygiène (1996), 54(2121), 1241-1245

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement ... [more ▼]

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement oncologique. Les radiations ionisantes sont capables d'induire une mort mitotique et une mort apoptotique. Nous définissons les caractéristiques radiobiologiques de chaque type de mort cellulaire et situons l'importance de l'apoptose pour la réponse tumorale aux radiations ionisantes. La modulation de ce «suicide cellulaire» devrait permettre une amélioration de l'index thérapeutique mais ceci implique une connaissance approfondie des mécanismes qui règlent l'apoptose [less ▲]

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See detailA propos d'un syndrome de Cushing d'origine indéterminée
Geenen, Vincent ULg

in Actualité Médicale Belge (1996), 513

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See detailPrognostic indices for mortality of hospitalized children in central Africa.
Dramaix, M.; Brasseur, D.; Donnen, P. et al

in American journal of epidemiology (1996), 143(12), 1235-43

A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This ... [more ▼]

A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This study analyzes the mortality in hospital; its objectives are to evaluate the prognostic power of edema and anthropometric and biologic indicators and to seek indices that perform better. Receiver operating characteristic curves were established for each parameter under study and for each index constructed. Areas under receiver operating characteristic curves were highest for biologic indicators, and simple indices, obtained by counting the number of risk factors present, performed best. In the absence of biologic parameters, the authors suggest classifying children as at risk of dying when they present with edema and/or with arm circumference of less than 115 mm. When biologic measurements are possible, in addition to edema and arm circumference, the authors suggest taking serum albumin and transthyretin into account. For serum albumin and transthyretin, mortality risk is defined in terms of values of less than 16 g/liter and 6.5 mg/dl, respectively. Children will be classified as at risk of dying when they present with at least two of the four risk factors. The resulting diagnostic test has a high sensitivity (91.2%) and positive and negative predictive values of 40.8% and 97.9%, respectively. [less ▲]

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See detailRelationship of Plasma Lactate Production to Cortisol Release Following Completion of Different Types of Sporting Events in Horses
Desmecht, Daniel ULg; Linden, Annick ULg; Amory, Hélène ULg et al

in Veterinary Research Communications (1996), 20(4), 371-379

Fifty-eight healthy horses were studied during five sporting events of various intensities and durations, namely show-jumping (n = 6), cross-country in a three-day event (n = 30), trotting races (n = 7 ... [more ▼]

Fifty-eight healthy horses were studied during five sporting events of various intensities and durations, namely show-jumping (n = 6), cross-country in a three-day event (n = 30), trotting races (n = 7), galloping races (n = 7) and endurance rides (n = 8). Venous blood samples were collected at rest and immediately after exercise and analysed for plasma cortisol (CORT) and lactate (LA) levels. The experimental procedure was the same throughout the investigation so as to permit a reliable comparison between the five types of exercise. The type of event significantly affected both the resting (p < or = 0.05) and the post-exercise (p < or = 0.01) plasma CORT. The degree of exercise-induced hypercortisolaemia was related to both the intensity and the duration of exercise for all five sporting events, but the endurance ride induced the most and show-jumping the least serious post-exercise CORT changes. LA production was much more closely related to the intensity of the exercise than was CORT. It is concluded that simultaneous measurements of plasma CORT and LA levels may be useful to discriminate between different types of exercise, adjust training programmes, and improve our comprehension of the physiology of sport horses at exercise. [less ▲]

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See detailRecent advances in drugs acting as tissue selective potassium channel openers
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Lebrun, P.

in Potassium Channel Modulators; ID Research Alert (1996), 1

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See detailL'endotoxémie dans l'espèce équine. 1ère partie: étiologie et physiopathologie.
Amory, Hélène ULg

in Pratique Vétérinaire Equine (1996), 28

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See detailThe Meaning of ``Formal''
Wolper, Pierre ULg

in ACM Computing Surveys (1996), 28(4es), 127

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See detailLaparoscopic myomectomy today. Fibroids: management and treatment: the state of the art.
Donnez, Jacques; Mathieu, Pierre Emmanuel; Bassil, Salim et al

in Human Reproduction (1996), 11(9), 1837-40

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See detailLes tempêtes (tempêtes extratropicales, cyclones tropicaux et tornades)
Erpicum, Michel ULg; Van Hoof, Th.

in Le point sur le I de Géographie (Soc géogr de Liège) (1996), 4

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See detailEstimations du taux de la plus-value en Belgique (1948-1994): méthode et résultats
Geerkens Provin, Eric ULg

in Contradictions (1996), (78-79), 85-98

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See detailUne banque de questions au service de l'évaluation formative dans l'enseignement technique du deuxième degré
Denis, Brigitte ULg; Bosmans, Catherine ULg; Jans, Véronique

in Informations pédagogiques (1996), (22), 23-33

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See detailImprovement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Tassoudji, Nazli ULg et al

in Journal of Dermatological Treatment (1996), 7

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This ... [more ▼]

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This study was conducted in 20 men who used a lotion containing the antimicrobials, piroctone olamine and triclosan, regularly for 18 months. At entry, mild pruritus and abnormal hair loss were reported by the volunteers. During treatments, pruritus resolved rapidly. Comparison of clinical photographs and trichograms taken at 3-month intervals suggested signs of hair regrowth with moderate increase in density of transitional hairs. Biopsies taken at 6-month intervals were processed for immunohistochemistry. There was a decrease in the density of activated T cells in the region of the follicular infrainfundibulum and isthmus over time. UgG deposits found within the epithelial sheaths at entry to the study were absent in the subsequent biopsies. The volume of the sebaceous glands, as assessed by computerized morphometry, was not modified by the treatment. It was concluded that inflammation associated with AGA transitional hairs may be driven by the presence of microorganisms harboured in the infrainfundibulum. They may modulate the severity of AGA and may potentially be controllable. This offers a new possibility of prevention and partial reversal of hair loss in AGA. [less ▲]

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See detailCosmological formation of low-mass objects
Haiman, Z.; Thoul, Anne ULg; Loeb, A.

in Astrophysical Journal (1996), 464(2), 523-538

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks ... [more ▼]

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks starting from the linear perturbative regime. The initial parameters correspond to density peaks of various widths and heights in a cold dark matter cosmology. We use a one-dimensional spherical Lagrangian hydrodynamics code to follow the dynamical, thermal, and nonequilibrium chemical evolution of the gas. The system includes a collisionless dark matter component and a baryonic component composed of the nine species H, H-, H+, He, He+, He++, H-2, H-2(+), and e(-). All relevant chemical reactions between these species and their cooling mechanisms are included in the calculations. We explore the dependence of the dynamical evolution of the gas on two parameters: the initial mass scale and the initial overdensity of the system. We follow the evolution of the density, temperature, and abundance profiles within the cloud, assuming two types of central boundary conditions for the collisionless component: in one the infalling dark matter virializes through a reflection from a hard sphere, while in the other it accretes onto a central sink. We find that in both cases, radiative cooling by H-2 affects the collapse dynamics of the gas only after it has already virialized and become part of the bound object. Therefore, radiative cooling is unlikely to have triggered the initial collapse of perturbations at redshifts z>10. Nevertheless, baryonic objects with masses well below the linear theory Jeans mass (less than or similar to 10(3) M.) form at high redshifts because of shell crossing by the dark matter. Such objects could be the progenitors of a primordial population of high-mass stars in the intergalactic medium. [less ▲]

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See detailInfection of cattle with Yersinia enterocolitica O:9 a cause of the false positive serological reactions in bovine brucellosis diagnostic tests.
Weynants, V.; Tibor, A.; Denoel, P. A. et al

in Veterinary Microbiology (1996), 48(1-2), 101-12

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of ... [more ▼]

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of brucellosis was reported in these animals and no Brucella abortus strains were isolated. After two years, no brucellosis outbreak was registered in all of the herds concerned. On this basis, all the serological reactions observed were classified as false positive. An ELISA using Yersinia Outer membrane Proteins (YOPs) as antigens was developed in order to discriminate between a Yersinia enterocolitica O:9 infection and a Brucella abortus infection. Antibodies against YOPs were detected in sera from Y. enterocolitica O:9 experimentally infected cattle (n = 4) but not in sera from B. abortus experimentally infected cattle (n = 4). In a field study, 66.7% of the 174 serum samples from cattle presenting false positive serological reactions showed anti-YOPs antibodies whereas only 10% of 454 sera, classified negative by the brucellosis screening tests, showed anti-YOPs antibodies. Our results suggest that infections with Y. enterocolitica O:9 may cause false positive reactions in brucellosis testing. [less ▲]

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See detailApproximation of reliability for multiple-trait animal models with missing data by canonical transformation
Gengler, Nicolas ULg; Misztal, I.

in Journal of Dairy Science (1996), 79(2), 317-328

An algorithm for approximation of reliability for multiple traits by multiple diagonalization was modified to support missing data by weighting transformed contributions of records based on the pattern of ... [more ▼]

An algorithm for approximation of reliability for multiple traits by multiple diagonalization was modified to support missing data by weighting transformed contributions of records based on the pattern of missing data. The accuracy of approximation was assessed with simulated and field data by comparing approximate reliabilities with those from direct inversion. Simulated data had several levels of missing data and covariances between traits; correlations were close to those for linear type traits of dairy cattle. Field data were 1) dairy records for milk, fat, and protein yields with 26% of the observations for fat and protein removed and 2) beef records for birth weight, weaning weight, and mean gain after weaning with 43% of observations missing. These files also contained empty fixed effect classes. The algorithm worked best for simulated data, and, when covariances between traits decreased, proportion of missing traits decreased and the number of empty fixed classes decreased. For dairy data, improvement over single-trait reliability occurred only for traits with missing data; for beef data, little or no improvement occurred. The method is useful with multiple diagonalization if the proportion of missing records or number of empty fixed effect classes or covariances between traits is moderate. [less ▲]

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1996), 37

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See detailHomogeneous Lyapunov Functions and Necessary Conditions for Stabilization
Sepulchre, Rodolphe ULg; Aeyels, D.

in Journal of mathematics for control, signal and systems (1996), 9(1), 34-58

We provide necessary conditions for the stabilization of nonlinear control systems with the additional requirement that a time-invariant homogeneous Lyapunov function exists for the closed-loop system.

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See detailNonspecific airway responsiveness of COPD horses : effects of environmental control
Vandenput, Sandrina ULg; Votion, Dominique ULg; Anciaux, N. et al

in Pflügers Archiv : European Journal of Physiology (1996), 431(6), 324

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See detailTabac et maladie parodontale
Geerts, Sabine ULg

in Actualités Dentaires de l'Université de Liège (1996), 19

Le tabac est un facteur aggravant la parodontite. Beaucoup d'études cliniques ont été menées et ont souvent montré des résultats contradictoires. Cet article est une revue de littérature sur la relation ... [more ▼]

Le tabac est un facteur aggravant la parodontite. Beaucoup d'études cliniques ont été menées et ont souvent montré des résultats contradictoires. Cet article est une revue de littérature sur la relation entre le tabagisme et la parodontite. [less ▲]

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See detailManger juste. Les droits de l'animal dans les encyclopédies de 1750 à 1800. De l'éthique au politique
Strivay, Lucienne ULg

in Colloques d'Histoire des Connaissances Zoologiques (1996), 7

Les encyclopédistes du 18° inclurent leurs définitions de la spécificité humaine par rapport à celle de l'animal dans leur nouvelle synthèse du savoir. A la même époque, resurgit le concept des "droits de ... [more ▼]

Les encyclopédistes du 18° inclurent leurs définitions de la spécificité humaine par rapport à celle de l'animal dans leur nouvelle synthèse du savoir. A la même époque, resurgit le concept des "droits de l'animal" (relayant les anciens procès intentés à des animaux). La communication examine comment Diderot et d'Alembert, Panckoucke, Robinet, De Lisle de Sales, Valmont de Bomare, etc., s'y prirent pour concilier les droits de l'homme et ceux de l'animal dans les articles de leurs encyclopédies. Si l'animal appartient à la catégorie de "l'autre", sa proximité avec l'homme, en raison du développement des premières intuitions transformistes et du sensualisme matérialiste, s'affirme de plus en plus, en opposition au cartésianisme qui considérait l'animal comme une machine et l'écartait, par essence, de l'homme et de Dieu. En conséquence, les points de vue qui s'expriment au siècle des Lumières au sujet des animaux ont suscité des idées dérangeantes sur le lien unissant tous les êtres vivants entre eux et, d'autre part, ils ont soulevé de nouvelles questions, les unes théoriques : au sujet de l'origine des espèces, les autres pratiques : sur le droit de l'homme à manger les animaux, le choix des viandes et ses conséquences morales, voire politiques. Car, fondé comme il l'est sur des formes de violence publique ou privée, l'abattage des animaux afin de produire de la viande a toujours eu de nombreuses implications, notamment sociales, propres à induire finalement des réformes ou des changements d'ensemble. [less ▲]

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See detailDe Bruxelles à la ferme : agriculture et environnement en Belgique
Mormont, Marc ULg

in Etudes Rurales (1996), (No. 141/142), 157-169

The implementation of environmental protection policies in Flanders and Wallonia (Belgium) is investigated, looking at the stages of application and the roles of the actors involved. The factors which ... [more ▼]

The implementation of environmental protection policies in Flanders and Wallonia (Belgium) is investigated, looking at the stages of application and the roles of the actors involved. The factors which intervene in the implementation of a European policy, whose characteristics include reformulation at local level, are identified. Structural and political factors affecting change in agricultural and environmental policies are outlined, including regionalization and the division of responsibilities. The example of Belgium shows how it is important that each authority can redefine its own interests in defending the environment using its own resources and contacts. Implementation at local level implies a series of re-interpretations of each agri-environmental measure in the light of expectations and the reactions of land-users. [less ▲]

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See detailActivated forms of MMP2 and MMP9 in abdominal aortic aneurysms.
SakalihasanN, Natzi ULg; Delvenne, Philippe ULg; Richelle, Betty ULg et al

in Journal of Vascular Surgery (1996), 24(1), 127-33

PURPOSE: This consistent observation of a reduction of the elastin concentration in abdominal aortic aneurysms (AAAs) has led us to investigate in AAA specimens two metalloproteinases that display ... [more ▼]

PURPOSE: This consistent observation of a reduction of the elastin concentration in abdominal aortic aneurysms (AAAs) has led us to investigate in AAA specimens two metalloproteinases that display elastase activity, MMP2 (gelatinase A/72kDa) and MMP9 (gelatinase B/92 kDa). METHODS: Samples of full-thickness aortic wall, adherent thrombus, and serum were collected in 10 patients with AAAs. Samples of normal aortic wall and serum were taken from 6 age-matched control patients. Quantitative gelatin-zymography and gelatinolytic soluble assays after acetyl-phenyl mercuric acid activation were performed on serum and tissue extracts, and the results were expressed in units on a comparative wet-weight basis. Histologic analysis was performed in parallel to score the inflammatory infiltrate. RESULTS: The luminal and parietal parts of the thrombus contained, respectively, 20- and 10-fold more gelantinolytic activity than the serum. The predominate form was MMP9. Although the total gelatinolytic activity was in the same range both in AAAs and in normal walls, a significantly higher proportion of MMP9 was found in the aneurysmal aortic walls. Furthermore, a significant proportion of MMP9 was under its processed active form, which was never observed in normal samples. A significantly higher proportion of MMP2 was also present as processed active form in AAA wall. This latter parameter positively correlated with the inflammatory score. CONCLUSIONS: The presence of activated MMP9 and MMP2 might contribute to the degradation of the extracellular matrix proteins that occurs during the development of aneurysms. [less ▲]

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See detailChemotaxis-Promoting and Adhesion Properties of Human Tonsillar Follicular Dendritic Cell Clusters
Bouzahzah, F.; Antoine, Nadine ULg; Simar, Léon ULg et al

in Research in Immunology (1996), 147(3, Mar-Apr), 165-73

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role ... [more ▼]

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role played by FDCs in attracting and binding cells. FDCs prepared from human tonsils by mild separation techniques appeared in the form of clusters (FDC clusters), where, via cytoplasmic extensions, they enveloped lymphoid cells. Using Boyden's chambers, we demonstrated that these FDC clusters produced one or more chemoattractants capable of inducing chemotaxis of lymphoid cells. Supernatants of FDC cluster cultures also exerted a chemotaxis-promoting effect. FDC clusters induced true chemotaxis, not merely chemokinesis due to cell activation. They secreted a substance or substances that stuck to the substrate (a cellulose filter) and thus induced haptotaxis. B as well as T cells were attracted, but B cells apparently required the presence of T cells to respond fully to the chemoattractant(s). Subtypes of B cells (IgD+ and IgD-) and T cells (CD4+, CD8+, CD57+ AND CD57-) were tested and all were attracted. Since purified lymphoid cells did not induce these phenomena, FDCs were suspected to do so. FDCs have been shown to establish contact with lymphoid cells. Here we have determined that CD4+ T cells adhere in greater number to FDC clusters than do CD8+ T cells. We thus propose that FDCs specifically contribute to construction of lymph follicles by attracting and determining their cell composition. [less ▲]

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See detailAge and correlation of the Barreinrinha Formation (Curua Group, Amazon Basin) : new evidence from the Miospore biostratigraphy
Loboziak, S.; Melo, J.H.G.; Rodriguez, R. et al

in Anais da Academia Brasileira de Ciencias (1996), 68(2), 207-212

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See detailSanglante campagne en Tchétchénie
Bachkatov, Nina ULg

in Monde Diplomatique (Le) : Journal des Cercles Diplomatiques et des Grandes Organisations Internationales (1996)

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See detailIBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15
Charlier, Carole ULg; Farnir, Frédéric ULg; Berzi, P. et al

in Genome Research (1996), 6

Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single ... [more ▼]

Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single acknowledged carrier founder individual. Between seven and nine generations separated the founder from its 12 affected descendents. The 12 affected offspring were genotyped for a battery of 213 microsatellites spanning the 29 bovine autosomes. The resulting genotypes were analyzed using a maximum likelihood approach searching for shared homozygous haplotypes among affected individuals. Three candidate regions for the syndactyly locus emerged from this initial screening. syndactyly was shown to map to one of these candidate regions on chromosome 15 by genotyping 29 additional individuals linking founder and affected offspring and performing a conventional linkage analysis with the LINKAGE programs. This study illustrates the potential of identity-by-descent mapping in livestock populations. [less ▲]

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See detailInteraction Of The Macrolide Azithromycin With Phospholipids .2. Biophysical And Computer-Aided Conformational Studies
Montenez, Jp.; Vanbambeke, F.; Piret, J. et al

in European Journal of Pharmacology (1996), 314(1-2), 215-27

In a comparison paper, we show the azithromycin causes a lysosomal phospholipidosis in cultured cells, binds in vitro to negatively charged bilayers without causing aggregation or fusion, and inhibits ... [more ▼]

In a comparison paper, we show the azithromycin causes a lysosomal phospholipidosis in cultured cells, binds in vitro to negatively charged bilayers without causing aggregation or fusion, and inhibits lysosomal phospholipase A1. In this paper, we show that azithromycin decreases the mobility of the phospholipids in negatively charged liposomes (using 31P nuclear magnetic resonance) and that it increases the fluidity of the acyl chains close to the hydrophilic/hydrophobic interface, but not deeper into the hydrophobic domain (assessed by measuring the fluorescence polarization of trimethylammonium-diphenylhexatriene and diphenyhexatriene, respectively). Computer-aided conformational analysis of mixed monolayers of azithromycin and phosphatidylinositol shows that the drug can be positioned largely in the hydrophobic domain, but close to the interface, with the macrocycle facing the C1 of the fatty acids (allowing the N9a endocyclic tertiary amine to interact with the phospho-groups), the cladinose located on the hydrophobic side of the lipid/water interface and the desosamine projected into the hydrophobic domain. This position is consistent with the experimental data. Analysis of virtual molecules shows that this unanticipated behavior to the shielding of the ionizable N3' amino-group in the desosamine by methyl-groups, and to the wide dispersion of hydrophobic domains all over the molecule. The interaction of azithromycin with phospholipids may account for some of its unusual pharmacokinetic properties and for its potential to cause lysosomal phospholipidosis. [less ▲]

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See detailRetard neuromoteur et neuropsychologique: critères de recours à une prise en charge spécialisée
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia et al

in Percentile (1996), .(3), 103-107

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See detailMeasurement of tomato firmness by using a non-destructive mechanical sensor
Lesage, Patrick; Destain, Marie-France ULg

in Postharvest Biology & Technology (1996), 8

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate ... [more ▼]

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate lever mechanism. A highly significant correlation exists between firmness measurements performed with this device and the Stable Micro Systems (SMS), fitted with the same plunger dimaeter. Using the Cantifruit, data related to firmness variability and changes are easily obtained. The firmness of tomatoes varies about 12 % around its circumference. In a single lot of tomatoes picked at the same time, the variability may exceed 25 %. If the tomatoes are stored at 4-5 °C and 92-99 % relative humidity (RH), their firmness decreases by about 20 % over ten days. [less ▲]

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See detailExperimental research on the determination of the main parameters affecting the behaviour of reinforced concrete columns under fire conditions
Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg; Bruls, Alois et al

in Magazine of Concrete Research (1996), 48(6), 117-127

The design of reinforced concrete columns under fire conditions is generally made on the basis of national and international recommendations. The CEB/FIP recommendations have been used for many years ... [more ▼]

The design of reinforced concrete columns under fire conditions is generally made on the basis of national and international recommendations. The CEB/FIP recommendations have been used for many years. Recently, in the framework of the Eurocodes, the document ENV 1992-1-2 (Eurocode 2-1-2), Structural fire design, has been approved by Commission CEN/TC250/SC2 of the European Committee for Standardization. In the CEB/FIP documents and in Eurocode 2-1-2 the main part is devoted to design from tabulated data containing the dimensions of the cross-sections and values for the concrete cover. The use of simplified calculation methods is not current practice for concrete elements, while they are widely used in the case of steel. The determination of the temperature distribution in the cross-section does not facilitate the development of a simplified method. Furthermore, in columns there is a wide scatter of experimental results. In order to gain additional information, an extensive experimental research programme on the behaviour of reinforced concrete columns under fire conditions, financially supported by the Belgian Funds for Fundamental Collective Research (FRFC-FKFO), has been performed at the Universities of Liege and Ghent. In this article the results of this research are presented and the influence of the main parameters is analysed. [less ▲]

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See detailLes Charites à Athènes et dans l’île de Cos
Pirenne-Delforge, Vinciane ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1996), 9

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See detailLa place des bisphosphonates dans le traitement de l’ostéoporose
Reginster, Jean-Yves ULg

in Lettre du Rhumatologue (La) (1996), 222

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See detailRené Zazzo, poète et psychologue
Richelle, Marc ULg

in Enfance (1996), (2), 233-237

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See detailTrends of OCS, HCN, SF6, CHClF2, (HCFC-22) in the lower stratosphere from 1985 and 1994 atmospheric trace molecule spectroscopy experiment measurements near 30 degrees N latitude
Rinsland, C. P.; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

in Geophysical Research Letters (1996), 23(17), 2349-2352

Volume mixing ratio (VMR) profiles of OCS, HCN, SF6, and CHClF2 (HCFC-22) have been measured near 30 degrees N latitude by the Atmospheric Trace Molecule Spectroscopy Fourier transform spectrometer during ... [more ▼]

Volume mixing ratio (VMR) profiles of OCS, HCN, SF6, and CHClF2 (HCFC-22) have been measured near 30 degrees N latitude by the Atmospheric Trace Molecule Spectroscopy Fourier transform spectrometer during shuttle flights on 29 April-6 May 1985 and 3-2 November 1994. The change in the concentration of each molecule in the lower stratosphere has been derived for this 9 1/2-year period by comparing measurements between potential temperatures of 395 to 800 K (similar to 17 to 30 km altitude) relative to simultaneously measured values of the long-lived tracer N2O. Exponential rates of increase inferred for 1985-to-1994 from these comparisons are (0.1 +/- 0.4)% yr(-1) for OCS, (1.0 +/- 1.0)% yr(-1) for HCN, (8.0+/-0.7)% yr(-1) for SF6, and (8.0 +/- 1.0)% yr(-1) for CHClF2 (HCFC-22), 1 sigma. The lack of an appreciable trend for OCS suggests the background (i.e., nonvolcanic) source of stratospheric aerosol was the same during the two periods. These results are compared with trends reported in the literature. [less ▲]

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See detailThe current situation of wild mammals in Belgium: an outline
Libois, Roland ULg

in Hystrix: the Italian Journal of Mammalogy (1996), 8(1-2), 35-41

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better ... [more ▼]

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better understanding of the current status of the different species. Conservation measures were olso proposed to the political authorities who thereafter edicted a legal protection of the most vulnerable species. Unfortunately, habitat protection is rather unachieved and the situation of the most endangered species is still getting worse. [less ▲]

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See detailLa place actuelle de l'immunoanalyse en Toxicologie Clinique
Charlier, Corinne ULg; Plomteux, Guy ULg

in Immuno-Analyse & Biologie Spécialisée [=IBS] (1996), 11

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See detailHypertension artérielle et antagonistes du récepteur de l'angiotensine II
Krzesinski, Jean-Marie ULg; Turatzinse, L.; Rorive, Georges ULg

in Médecine et Hygiène (1996), 2127

Dans l'hypertension artérielle et la décompensation cardiaque, les inhibiteurs de l'enzyme de conversion constituent un outil thérapeutique important mais, parfois, au prix de certains effets secondaires ... [more ▼]

Dans l'hypertension artérielle et la décompensation cardiaque, les inhibiteurs de l'enzyme de conversion constituent un outil thérapeutique important mais, parfois, au prix de certains effets secondaires (par exemple, la toux). De nouvelles perspectives de contrôle du système rénine angiotensine-aldostérone se profilent à l'horizon avec l'avènement des antagonistes des récepteurs de l'angiotensine Il. Le losartan est lepremier agent de cette famille, de nature non peptidique et actif par voie orale. Sa longue durée d'action permet une seule administration par jour. Cet agent bloque tous les effets connus de l'angiotensine II par une action au niveau des récepteurs appelés AT1. Au vu des premiers résultats publiés, il constitue un concurrent des inhibiteurs de l'enzyme de conversion dans l'hypertension et la décompensation cardiaque. [less ▲]

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See detailArthrite septique du boulet : corrélation entre imagerie et examen anatomo-pathologique
Busoni, Valeria ULg; Rossi, Giacomo; Denoix, Jean-Marie

in Pratique Vétérinaire Equine (1996), 28

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See detailRevisiting the evaluation of the performance of fluid-filled catheters
GERARD, P; POCHET, T; LAMBERMONT, Bernard ULg et al

in Medical & Biological Engineering & Computing (1996), 34

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See detailTreatment of osteoporosis: where are we and where are we going to
Reginster, Jean-Yves ULg

in Revista de Reumatologia (1996), 4

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See detailPollution des sols : interventions et responsabilités des pouvoirs publics
Delnoy, Michel ULg

in Sols contaminés, sols à décontaminer (1996)

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See detailTwo rare European Ephemerum species (Bryophita): E. cohaerens rediscovered near Strasbourg (France) and E. stellatum new to Belgium
Vanderpoorten, Alain ULg; Stieperaere, H.; Klein, J.-P.

in Belgian Journal of Botany (1996), 129

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See detailPreliminary study of the Black Sea's plankton bloom
Grégoire, Marilaure ULg; Beckers, Jean-Marie ULg; Nihoul, Jacques ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1996), 65(1), 91-94

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See detailCellular Pathways Involved In The Ex Vivo Expression Of Bovine Leukemia Virus
Kerkhofs, P.; Adam, E.; Droogmans, L. et al

in Journal of Virology (1996), 70(4),

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See detailThe Ahrensburgian site at Zonhoven-Molenheide
Vermeersch, Pierre M.; Peleman, Chris; Rots, Veerle ULg et al

in Notae Praehistoricae (1996), 16

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See detailHypertension and left ventricular hypertrophy
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg; Van Cauwenberge, Henry

in Acta Cardiologica (1996), 51(2), 143-154

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age ... [more ▼]

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age, gender, weight, race, genetics and the severity of high blood pressure. By echocardiography, it has been possible to detect non invasively and more precisely this hypertrophy and its anatomical pattern which is not uniform. This cardiac response is influenced by hemodynamic but also by non hemodynamic factors, but the exact mechanisms are not yet well understood. The humoral and tropic factors particularly affect the cardiac remodeling. Left ventricular hypertrophy has been noted by itself to be an independent risk factor for sudden death, ventricular arrhythmias, myocardial ischemia, and heart failure. Very early hypertension, diastolic dysfunction is noted. The progression to systolic failure in moderate hypertension usually occurs over several decades. According to the worse prognosis of left ventricular hypertrophy, it has been suggested that the reversibility of this anatomical modification by antihypertensive treatment is beneficial. Preliminary data support this idea. [less ▲]

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See detailLe cas clinique du mois : syndrome de Moskowitz chez un patient traité par ticlopidine
FRANCHIMONT, D; Freres, Pierre ULg; LEBRUN, F et al

in Revue Médicale de Liège (1996), 51(3), 214-216

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See detailParcours d’un chartiste : Robert-Henri Bautier et le recueil de ses articles
Marchandisse, Alain ULg

in Moyen Age (Le) (1996), 102

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See detailCardio-respiratory adjustments and arterial blood gases in exercising horses in crisis and in clinical remission
Art, Tatiana ULg; Anciaux, N.; Duvivier, H. et al

in Pferdeheilkunde (1996), 12(4), 717-718

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See detailTransition probabilities for [Ni I] and [Ni II] lines
Quinet, Pascal ULg; Le Dourneuf, M

in Astronomy and Astrophysics. Supplement Series (1996), 119

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See detailLe campus universitaire comme espace public : des représentations aux pratiques
Frankignoulle, Pierre ULg; Bodson, Edith

in Etudes de Communication (1996), 18

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See detailPrévention de l’ostéoporose à Liège. Histoire d’un PIGEPS : dix ans plus tard.
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; LECART, Marie-Paule ULg et al

in Santé Publique : Revue Multidisciplinaire pour la Recherche et l'Action (1996), 2

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See detailDetection And Identification Of Sweet Potato Viruses By The Polymerase Chain Reaction
Colinet, D.; Lepoivre, Philippe ULg; Xia, Fz. et al

in Agro Food Industry Hi-Tech (1996), 7(2),

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See detailLe cheval de trait ardennais convient-il pour l'attelage sportif
Crigel, MH; Art, Tatiana ULg; Votion, Dominique ULg et al

in Pratique Vétérinaire Equine (1996), 28

The Ardennais draught horse (DH) is more and more used for harnessing competitions. The aim of this study was to improve our knowledge of its cardiorespiratory peculiarities, both at rest and during ... [more ▼]

The Ardennais draught horse (DH) is more and more used for harnessing competitions. The aim of this study was to improve our knowledge of its cardiorespiratory peculiarities, both at rest and during exercise. At rest, arterial blood gas analysis, venous blood analysis, a test of mechanics of breathing and an endoscopy of the upper airways were performed. Experiments during exercise were performed on a treadmill. The intensity of the standardised test was sufficient to overshoot the OBLA threshold. The test was of increasing intensity and lasted 22 min. The cardiorespiratory parameters were measured during the last 5 min. Expired volume minute (VE), VT and f were measured. Respiratory O2 and CO2 fraction were measured with a mass spectrometer. Oxygen uptake (VOA, CO2 output (VCO2) and VE/VO2 were calculated. Heart rate (HR) was continuously measured.The results were compared to data recorded in standarbred horses (SH) during a treadmill exercise test leading to a similar lactaci¬demia (LA) and peak HR.The DH have a significantly lower V02 than the SH while running at an exercise intensity inducing the same HR and LA modifications. The lower aerobic capacity of DH was at least partly correlated with their higher cost of breathing and lower blood gas transport capacity.Moreover, other measurements have been performed infield conditions, during 4 draft competitions, i.e. speed, maniability, power and endurance. Venous blood analyses before and after the competition, heart rate and body temperature measurements were performed. The results of this second set of measurements confirm the results obtained in the laboratory and allow assessing that these kinds of competition do not induce dramatic physiological modifications and therefore respect the welfare and limits of these horses. [less ▲]

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See detailThe degree/rapidity of the metabolic deterioration following interruption of a continuous subcutaneous insulin infusion is influenced by the prevailing blood glucose Level.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Journal of Clinical Endocrinology and Metabolism (1996), 81(5), 1975-8

This study aims at investigating the influence of the prevailing blood glucose level on the metabolic deterioration that follows a nocturnal interruption of a continuous sc insulin infusion (CSII ... [more ▼]

This study aims at investigating the influence of the prevailing blood glucose level on the metabolic deterioration that follows a nocturnal interruption of a continuous sc insulin infusion (CSII). Fifteen CSII-treated, C-peptide negative, diabetic patients have been studied CSII was interrupted from 2300 h to 0500 h. Blood was collected hourly from 2200 h to 0600 h. According to blood glucose (BG) levels at 2300 h, patients were classified as hypoglycemic (BG between 1.5 and 2.5 mmol/L, n = 5), normoglycemic (BG between 4.0 and 8.0 mmol/L, n = 5), or hyperglycemic (BG between 9.0 and 15.0 mmol/L, n = 5). At 2300 h, BG (mean +/- SEM) was 1.9 +/- 0.1, 6.2 +/- 0.7 and 11.2 +/- 1.0 mmol/L, respectively. After 6 h of CSII interruption, BG increased to 13.5 +/- 1.3, 14.1 +/- 1.2, and 19.4 +/- 1.2 mmol/L, respectively. At 2300 h, plasma 3-OH-butyrate levels were similar in the three groups (around 150 micromol/L). At 0500 h, significantly higher values were obtained for hyperglycemic (1460 +/- 127 micromol/L) than for normoglycemic (868 +/- 150 micromol/L) or hypoglycemic (837 +/- 80 micromol/L) patients. Enhanced lipolysis in initially hyperglycemic patients may contribute to accelerated ketogenesis and metabolic degradation. In conclusion, the metabolic deterioration that follows CSII interruption is influenced by the initial metabolic situation. Hypoglycemic patients deteriorate more rapidly, and hyperglycemic patients suffer a more important degradation. The latter are prone to rapid ketoacidosis if accidental CSII interruption occurs. [less ▲]

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See detailPhylogenetic Relationships of Nonaxenic Filamentous Cyanobacterial Strains Based on 16S rRNA Sequence Analysis
Nelissen, Bart; De Baere, Raymond; Wilmotte, Annick ULg et al

in Journal of Molecular Evolution (1996), 42

In order to determine the nearly complete 16S rRNA gene sequences of cyanobacteria originating from nonaxenic cultures, a cyanobacterium-specific oligonucleotide probe was developed to distinguish ... [more ▼]

In order to determine the nearly complete 16S rRNA gene sequences of cyanobacteria originating from nonaxenic cultures, a cyanobacterium-specific oligonucleotide probe was developed to distinguish polymerase chain reaction (PCR) products of the cyanobacterial rRNA operons from those resulting from amplification of contaminating bacteria. Using this screening method the 16S rRNA genes of four nonaxenic filamentous cyanobacterial strains belonging to the genera Leptolyngbya and OscitIatoria were cloned and sequenced. For the genus Leptolyngbya, the 16S rRNA sequence of the axenic strain PCC 73110 was also determined. Phylogenetic trees were constructed based on complete and partial sequences. The results show that the strains Leptolyngbya Jbveolarum Kom~rek 1964/112, Leptolyngbya sp. VRUC 135 Albertano t985/1, and LeptoIyngbya boryanum PCC 73110 belong to the same cluster. Strain Oscillatoria cf. corallinae SAG 8.92, which contains the rare photosynthetic pigment CUphycoerythrin, is not closely related to other CUphycoerythrin- containing cyanobacteria. Oscillatoria agardhii CYA 18, which is a representative of planktonic Oscillatoria species that form toxic blooms in Norwegian inland waters, has no close relatives in the tree. [less ▲]

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See detailSequence stratigraphy of the Frasnian-Famennian transitional strata: a comparison between South China and Southern Belgium
Muchez, P.; Boulvain, Frédéric ULg; Dreesen, R. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (1996), 123

The sedimentological evolution of the Frasnian-Famennian transitional strata in South China and southern Belgium has been investigated. A similar trend in the deepening and shallowing of the sedimentation ... [more ▼]

The sedimentological evolution of the Frasnian-Famennian transitional strata in South China and southern Belgium has been investigated. A similar trend in the deepening and shallowing of the sedimentation environment occurs in the two palaeogeographically distinct areas. The stratigraphic succession has been subdivided into depositional sequences. A general deepening occurs in the Palmatolepis rhenana conodont zone. During the most rapid rise in sea level, a transgressive systems tract formed. This transgressive systems tract is followed by a highstand systems tract in the late P. rhenana zone. A major sequence boundary within the latter zone is indicated by an unconformity in intraplatform and platform areas and by a conformity in the basinal area. The uppermost sediments within the late rhenana zone correspond to a lowstand systems tract. A rapid flooding took place near the base of the Palmatolepis linguiformis zone and dark shales and limestones formed. A second sequence boundary coincides with or is very close to the Frasnian-Famennian boundary (base P. triangularis zone). The global extinction event at the Frasnian- Famennian boundary coincides with an important eustatic fall in sea level. The proposed stratigraphic subdivision should allow worldwide correlations of shallow and deep water deposits. [less ▲]

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See detailUtilisation des antibiotiques dans la maladie de Crohn : de la théorie à la pratique
Louis, Edouard ULg; Drion, V.; Belaiche, Jacques ULg

in Médecine et Hygiène (1996), 54

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See detailQuantitative measurement of metal ions concentration of proteins separated by electrophoresis
Weber, Georges ULg; Strivay, David ULg; Menendez, M. et al

in International Journal of PIXE (1996), 1-2

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the ... [more ▼]

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the electrophoresis, the gel is dried and each track is scanned with a 2.5 MeV proton beam which triggers metal X-ray fluorescence and then, allows to determine the type of metals contained in an electrophoretic band. For quantitative determination of the amount of the metal contained inside the band, the characteristic X-ray peak area is compared with those obtained with polyacrylamide gels doped with the same metal. The normalization has been achieved by using RBS measurements on the gel itself. The procedure presented seems to be a very useful multielementary method for the metal content analysis and for the determination of the metal amounts inside proteins after their separation by electrophoresis. Furthermore it allows to check if metals remain bound to proteins. [less ▲]

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See detailRetizonomonoletes hunanensis Fang et al. 1993 and the Retispora lepidophyta morphon.
Steemans, Philippe ULg; Fang, Xiaosi; Streel, Maurice ULg

in Inst. Géol. de l'Univ. Louvain (1996), 36

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See detailLe développement local : introduction et bilan et conclusions
Merenne-Schoumaker, Bernadette ULg

in Géographies. Bulletin de l'Association de Géographes Français (1996), (5), 382-385464-467

Introduction and conclusions of a conference we organized in Liege in order to bring together Francophone researchers in local development

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See detailShedding of the 67-kD laminin receptor by human cancer cells.
Karpatova, M.; Tagliabue, E.; Castronovo, Vincenzo ULg et al

in Journal of Cellular Biochemistry (1996), 60(2), 226-34

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix ... [more ▼]

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix has been recently suggested by electron microscopy studies, there is to date no evidence of shedding of the 67LR from cells. Using two monoclonal antibodies directed against the 67LR, we developed a double-determinant radioimmunoassay that demonstrates that the 67LR is released from cancer cells into the culture medium. The shed molecule exhibited the same apparent molecular weight as that of the membrane-associated 67LR, suggesting that no proteolytic cleavage is involved in the process. Furthermore, we demonstrate that the 67LR is not anchored to the membrane through a glycolsyl-phosphatidylinositol bridge. However, the observation that lactose increased the release of 67LR suggests that a lectin-type interaction is involved in the cell membrane association of this laminin binding protein and the cell surface. Interestingly, the released 67LR recovered after HPLC gel filtration was found free as well as associated to high molecular weight complexes. The free 67LR retained its ability to bind to the cell surface. Our study is the first demonstration that the 67LR is effectively shed by cancer cells. The released free 67LR could play an important role in modulating interactions between cancer cells and laminin during tumor invasion and metastasis. [less ▲]

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See detailLa gale psoroptique bovine. Une maladie éradicable ?
Mignon, Bernard ULg; Lonneux, J. F.; Losson, Bertrand ULg

in Sillon Belge (1996), 20.12.1996

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See detailA field observation on the influence of aggressive behaviour on mating success in the European grayling
Poncin, Pascal ULg

in Journal of Fish Biology (1996), 48(4), 802-804

The biggest male grayling present on a spawning area was strongly territorial and developed more aggressive behaviours than smaller males. However, its spawning frequency was similar to that of smaller ... [more ▼]

The biggest male grayling present on a spawning area was strongly territorial and developed more aggressive behaviours than smaller males. However, its spawning frequency was similar to that of smaller males. (C) 1996 The Fisheries Society of the British Isles [less ▲]

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See detailAntithrombin III in the therapy of severe sepsis
Lamy, Maurice ULg; Eisele, B.

in Biomedical Progress (1996), 9

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See detailHyperfine structure of infrared Al II lines
Palmeri, P.; Biémont, Emile ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailLanguage in adults with Down syndrome
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Down's Syndrome, Research and Practice : The Journal of the Sarah Duffen Centre (1996), 4(1), 3-14

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language ... [more ▼]

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language or some aspects of it beyond adolescence and during the adult years? This question is related to the issue of a critical period for language development raised by Eric Lenneberg (1967). Third, what is the effect of ageing on the language of persons with Down syndrome, including those who develop Alzheimer disease in old age? [less ▲]

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See detailLes "deux cultures" et la tâche de la philosophie
Bouquiaux, Laurence ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1996)

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See detailAuguste à Eleusis. Un aspect méconnu de l'idéologiqe augustéenne
Rochette, Bruno ULg

in Cahiers de Clio (1996), 127(automne), 3-14

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See detailEvaluation du débit sanguin au niveau du quadriceps électrostimulé et contracté volontairement
Vanderthommen, Marc ULg; BAUVIR, Philippe ULg; Depresseux, J.C. et al

in Annales de Kinésithérapie (1996), 23(1), 20-23

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See detailModulation Of Cd3-Gamma Gene Expression After Hiv Type 1 Infection Of The We17/10 T Cell Line Is Progressive And Occurs In Concert With Decreased Production Of Viral P24 Antigen
Willardgallo, Ke.; Delmellewibaut, C.; Segurazapata, I. et al

in Aids Research and Human Retroviruses (1996), 12(8),

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See detailMarsilio Ficino and Political Syncretism in Ian McEwan's Black Dogs
Delville, Michel ULg

in Notes on Contemporary Literature (1996), XXIV(3), 11-12

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See detailRéactions physiologiques face à des conditions extrêmes de chaleur et d'humidité relative: Etude des effets de l'exercice
Art, Tatiana ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (1996), 28

The purpose of this study was to investigate the effect of a hot and humid environment on the pattern of breathing and the gas exchange in heavily exercising horses. Five healthy fit standardbred horses ... [more ▼]

The purpose of this study was to investigate the effect of a hot and humid environment on the pattern of breathing and the gas exchange in heavily exercising horses. Five healthy fit standardbred horses (493± 14 kg; 4± 0,5yrs) were investigated twice at eight days interval, once in temperated atmos¬pheric conditions (TC) (ambient temperature : 15o C; relative humidity : 55 %) and once in hot and humid conditions (HHC) (ambient temperature : 30°C; relative humidity : 75 %). The standardized treadmill exercise test consisted in 8 min warm-up and in 8 min exer¬cise (1 min at 1,7, 4, 7, 8, 9 and 10 m/sec and 2 min at 4 m/sec with a 6% slope). Respiratory airflow, tidal volume, respiratory frequency as well as the 02 and C02 fraction in the inspired and expired gases were continuously recorded, using 2 ultrasonic pneumo¬tachographs connected to a face mask and a mass spectrometer. Oxygen uptake (VO2, carbon dioxide output (VCO2,), respiratory quotient (RQ) and expired minute volume (VE.) as well as alveolar partial pressure in C02 (PAC02) were obtained on a breath-by--breath basis. The maximal values obtained during the highest intensity were used for the comparison between both tests. Heart rate and skip temperature were continuously recorded, using a heart rate recording system and a real time infrared thermographic unit, respecti¬vely. Venous blood was sampled before and 2 min after the completion of the test for hematological and biochemical analysis, namely plasma lactate (LA), beta-endorphins, cortisol (Cor). Running in HHC induced a significant decrease in peak VE, VO2, VCO2 and oxygen pulse, while RQ remained unchanged and PAC02 increased. The changes in skin temperature (ST), i.e. the difference between ST at rest and at 10 m/sec, was dramatically higher in HHC. As well, the test-induced changes, i.e. the differences between the values before and after the test, in Cor, beta-endorphins and LA values after the test were significantly higher. This study shows that performing a strenuous exercise in hot, humid conditions in unacclimatized horses induced a reduction of the aerobic capacity, i.e. decrease of the VO2 and increase of LA production. A relative hypoventilation could be partly responsible for this observation, but all the steps of the oxygen transport from the pulmonary ventilation to the muscle metabolism could also potentially be impaired in such conditions [less ▲]

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See detailLa genèse du héros médiocre. Simenon à l'époque Fayard
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (1996), (8), 27-42

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See detailQuel encadrement pour quelle qualité de l'enseignement?
Lafontaine, Dominique ULg

in Pilotinfo (1996), (13), 1-8

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See detailComparative evaluation of impulse oscillometry and a monofrequency forced oscillation technique in clinically healthy calves undergoing bronchochallenges
Reinhold, Petra; MacLeod, D.; Lekeux, Pierre ULg

in Research in Veterinary Science (1996), 61

Multifrequency impulse oscillometry (IOS) was compared with a monofrequency forced oscillation technique (MFO) in calves undergoing experimentally induced bronchoconstriction and subsequent ... [more ▼]

Multifrequency impulse oscillometry (IOS) was compared with a monofrequency forced oscillation technique (MFO) in calves undergoing experimentally induced bronchoconstriction and subsequent bronchodilatation. The dynamic lung compliance (Cdyn) was also measured by conventional methods. For each test, the baseline mean and the responses to saline, a bronchoconstrictive agent (carbachol) and a bronchodilator (fenoterolhydrobromide) were calculated. Using the IOS, the information was markedly frequency-dependent. The resistance (R) and the magnitude of respiratory impedance (Z) were only sensitive at 5 Hz, leading to negative frequency dependence of these parameters as an indicator of peripheral airway obstruction. A high sensitivity for reactance (X) and phase angle phi values was observed between 5 and 20 Hz. For MFO (10 Hz), the parameters Ros (which includes resistive and capacitive components of the respiratory system), phase shift (psi), and the oscillatory derived compliance of the respiratory system (Crs) were of the greatest clinical potential. Crs showed a significant coefficient of linear correlation (r = 0.88, P < 0.001) with Cdyn. At the 10 Hz test frequency similar results were observed with MFO and IOS, suggesting that for healthy calves the measurement effect of an impulse is not significant. With respect to peripheral airway calibre, a test frequency less than 10 Hz appeared to be most sensitive and least variable. [less ▲]

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See detailElectrical microenvironment influence on the hydrolytic activity of free and immobilised Yarrowia lipolytica lipase
Paquot, Michel ULg; Deleu, Magali ULg; Beaufils, C. et al

in Biotechnology Letters (1996), 18(1), 73-78

The role of electrical properties of interfaces upon the activity of free and immobilised Yarrowia lipolytica lipase has been investigated. Sodium taurocholate and Sedipur 400, an anionic polyacrylamide ... [more ▼]

The role of electrical properties of interfaces upon the activity of free and immobilised Yarrowia lipolytica lipase has been investigated. Sodium taurocholate and Sedipur 400, an anionic polyacrylamide, enhance the negative character of the fatty droplets of substrate and tend to improve the lipolytic activity while the cationic polyacrylamide (Sedipur 900) has opposite effects. Ca+ which reduces the fatty droplets charge as Sedipur 900, is however a good activator of the enzyme. The role of electrical properties on the optimum pH of the immobilised enzyme is clearer. Immobilisation of the lipase on a positively charged support shifts its optimum pH to acidic pH by repulsion towards H+ ions around the support. [less ▲]

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See detailOrdovician and Silurian cryptospores and miospores from southeastern Turkey
Steemans, Philippe ULg; Le Hérissé, A; Bozdogan, N

in Review of Palaeobotany and Palynology (1996), 93(1-4), 35-76

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See detailL'immaginario lunare
Curreri, Luciano ULg

in La Battana (1996), 120

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See detailLa santé face aux nouveaux mécanismes de production et de gestion des inégalités sociales
Gavray, Claire ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1996), 11-12

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See detailHyperfine structure of Sc I by Infrared Fourier Transform Spectroscopy
Aboussaïd, A.; Carleer, M.; Hurtmans, D. et al

in Physica Scripta (1996), 53

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See detailBactericidal activity against Pseudomonas aeruginosa is acquired by cultured human monocyte-derived macrophages after uptake of myeloperoxidase.
Mathy-Hartert, M.; Deby, Ginette ULg; Melin, Pierrette ULg et al

in Experientia (1996), 52(2), 167-74

Myeloperoxidase (MPO) is an enzyme located within polymorphonuclear neutrophils capable of producing cytotoxic oxidant species that are particularly active against bacteria with polysaccharide capsules ... [more ▼]

Myeloperoxidase (MPO) is an enzyme located within polymorphonuclear neutrophils capable of producing cytotoxic oxidant species that are particularly active against bacteria with polysaccharide capsules. Pseudomonas aeruginosa (10(6) bacteria per 1ml) are killed within 1 h in vitro by a MPO/H2O2/C1- system (48mU=132ng of MPO). The question arose as to whether human macrophages would acquire cytotoxic activity when loaded with this enzyme. Monocytes were therefore isolated from human blood and cultured for up to ten days to induce maturation to macrophages. These cells lost endogenous MPO within five days while H2O2 production in response to stimulation by phorbol myristate acetate (10(-6)M) decreased to 23% within ten days. On the other hand, their capacity to take up exogenous MPO increased fourfold from day three to day ten. Human macrophages cultured from eight days (when both H2O2 production and MPO uptake were sufficient) were therefore used to study the effects of MPO uptake on cytocidal activity against Pseudomonas aeruginosa. After a 1 h MPO loading period, macrophages (5X10(5) cells per ml) were incubated in the presence of bacteria (0.5 to 2X10(6) bacteria per ml) for 2 h at 37 degrees C. At a bacteria/macrophage ratio of 1, only 34.8+/-7.0% of bacteria survived (compared to killing by non-loaded macrophages), while 74.4+/-9.3% survived at a ratio of 4. From these results, we conclude that loading macrophages with exogenous MPO could enhance their microbicidal activity, suggesting a potentially useful therapeutic application. [less ▲]

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See detailFactors influencing the behavior of steel columns exposed to fire
Talamona, Didier; Kruppa, Joël; Franssen, Jean-Marc ULg et al

in Journal of Fire Protection Engineering (1996), 8(1), 31-43

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See detailReconnaissance des malformations et pathologies prénatales du système nerveux central
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia

in Acta Paediatrica Belgica (1996), 28(3), 204-215

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See detailThe seasonality of the CO2 exchange between the atmosphere and the land biosphere: A study with a global mechanistic vegetation model
Nemry, B.; François, Louis ULg; Warnant, Pierre ULg et al

in Journal of Geophysical Research (1996), 101(D3), 7111-7125

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR ... [more ▼]

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR), and a mechanistic model of carbon assimilation in the biosphere (CARAIB) that estimates the net primary production (NPP) of continental vegetation. The steady state hypothesis of the biosphere allows the spatial distribution and the global content of the soil carbon to be expressed as a function of the root fractions of soil respiration under forested and herbaceous vegetation covers. The sensitivity of the modeled CO2 signal to the wind field does not exceed the observed interannual variability. The influence of the various vegetation zones is quantified by the Fourier analysis of the modeled atmospheric signal. In the northern hemisphere, the temperate ecosystems dominate the seasonal atmospheric signal of the extratropical latitudes. The ecosystems of the tropical northern zone determine the local signal, while the southern tropical ecosystems influence largely the signal in the whole southern hemisphere. The results give credence to the mechanistic modeling of NPP since the simulated atmospheric signal is comparable with that obtained with normalized difference vegetation index (NDVI) based diagnostic models coupled with a parameterization of SHR fitted to optimize the atmospheric signal. [less ▲]

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See detailDemande d'indemnisation des dommages dus aux plans : éléments de recevabilité et de fondement
Delnoy, Michel ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1996)

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See detailCloning of choriocarcinoma cells shows that invasion correlates with expression and activation of gelatinase A
Crescimanno, C.; Foidart, Jean-Michel ULg; Noël, Agnès ULg et al

in Experimental Cell Research (1996), 227

Implantation and placental development are dependent upon trophoblast invasion of the endometrium. While the villous trophoblast does not display invasive behavior, the extravillous cytotrophoblast is ... [more ▼]

Implantation and placental development are dependent upon trophoblast invasion of the endometrium. While the villous trophoblast does not display invasive behavior, the extravillous cytotrophoblast is highly invasive. By cloning BeWo choriocarcinoma cells, we have isolated two distinct clones that share similarities with villous and extravillous cytotrophoblasts. When cultured at the surface of a type I collagen gel, BeWo MC-1 cells were not invasive, whereas BeWo MC-2 cells rapidly invaded this matrix. When injected subcutaneously in nude mice, BeWo MC-1 cells developed a localized tumor and BeWo MC-2 cells developed larger tumors with micrometastases. Gelatinase A expression and minute amounts of gelatinase B were detected in the parental cell line and in both clones. However, the parental and the BeWo MC-2 cells secreted 5- to 10-fold more gelatinase A than the BeWo MC-1 cells. Laminin and matrigel stimulated the production of gelatinase A in BeWo MC-2 cells. Type I collagen promoted the conversion of the 72-kDa progelatinase A in an active enzyme only in parental BeWo and in BeWo MC-2 cells. These clones provide an interesting model for studying the complex mechanisms regulating implantation as well as the controlled invasiveness during implantation compared to tumor invasion. [less ▲]

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See detailCaractéristiques des lésions résultant d'une pathologie périnatale
Dubru, Jean-Marie ULg; Leroy, Patricia; Misson, Jean-Paul ULg

in Acta Paediatrica Belgica (1996), 28(3), 203-204

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See detailThe Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment: Deployment on the ATLAS Space Shuttle missions
Gunson, Michael R.; Abbas, M. M.; Abrams, M. C. et al

in Geophysical Research Letters (1996), 23(17), 2333-2336

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events ... [more ▼]

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events provided measurements of more than 30 atmospheric trace gases at latitudes 3-49 degrees N and 65-72 degrees S, including observations both inside and outside the Antarctic polar vortex. The instrument configuration, data retrieval methodology, and mission background are described to place in context analyses of ATMOS data presented in this issue. [less ▲]

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See detailBrain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
Mastrogiacomo, Frank; Lindsay, J. Gordon; Bettendorff, Lucien ULg et al

in Annals of Neurology (1996), 39

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See detailQuestions de regards
Havelange, Carl ULg

in Le Carnet et les Instants (1996), septembre-novembre 1996(n° 94), 57

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