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See detailAlteration of thyroid hormones, insulin-like growth factor-I (IGF-I) and IGFBPs in finishing calves treated with dexamethasone
Bertozzi, Carlo; Massart, Serge; Darras, Veerle et al

in Canadian Journal of Animal Science (2000), 80

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See detailEvaluation of EMIT tox benzodiazepine and barbiturate assays on the Vitalab Viva analyser and FPIA on the Abbott ADx analyser
Charlier, Corinne ULg; Plomteux, Guy ULg

in Clinical Chemistry & Laboratory Medicine (2000), 38(7), 615-618

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in ... [more ▼]

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in preliminary therapeutic drug monitoring or acute drug intoxication detection. Performance, as indicated by CVs, of the Emit® tox benzodiazepine and barbiturate assays and FPIA showed that both immunochemical techniques are precise and have good reproducibility. For within-run studies, results from benzodiazepine determinations showed maximum CV values of 1.91% for the Emit® method and 2.65% for FPIA; results from barbiturate determinations showed maximum CV values of 2.01% for the Emit® method and 1.89% for FPIA. For between-run studies, results from benzodiazepine determinations showed maximum CV values of 1.79% for the Emit® method and 1.12% for FPIA; results from barbiturate determinations showed maximum CV values of 2.09% for the Emit® method and 2.02% for FPIA. [less ▲]

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See detailStructural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase.
Chantalat, L.; Duee, E.; Galleni, Moreno ULg et al

in Protein science : a publication of the Protein Society (2000), 9(7), 1402-6

Beta-lactamases are involved in bacterial resistance. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are becoming thus of major clinical importance. Despite the ... [more ▼]

Beta-lactamases are involved in bacterial resistance. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are becoming thus of major clinical importance. Despite the availability of Zn-beta-lactamase X-ray structures their mechanism of action is still unclear. One puzzling observation is the presence of one or two zincs in the active site. To aid in assessing the role of zinc content in beta-lactam hydrolysis, the replacement by Ser of the zinc-liganding residue Cys168 in the Zn-beta-lactamase from Bacillus cereus strain 569/H/9 was carried out: the mutant enzyme (C168S) is inactive in the mono-Zn form, but active in the di-Zn form. The structure of the mono-Zn form of the C168S mutant has been determined at 1.85 A resolution. Ser168 occupies the same position as Cys168 in the wild-type enzyme. The protein residues mostly affected by the mutation are Asp90-Arg91 and His210. A critical factor for the activity of the mono-Zn species is the distance between Asp90 and the Zn ion, which is controlled by Arg91: a slight movement of Asp90 impairs catalysis. The evolution of a large superfamily including Zn-beta-lactamases suggests that they may not all share the same mechanism. [less ▲]

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See detailLa quittance BGU VII 1589
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (2000), LXXV(149), 111-117

BGU VII, 1589 (Philadelphia, 166/7 A.D.) in an intermediate receipt (antisymbolon). The nomographos is no tax collector.

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See detailPulmonary perfusion redistribution in exercises horses
Votion, Dominique ULg; Harmegnies, N. F.; Duvivier, D. H. et al

in European Journal of Nuclear Medicine (2000), 41

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See detailTropisetron in the prevention of postoperative nausea and vomiting.
Boogaerts, J G; Bardiau, Françoise ULg; Seidel, Laurence ULg et al

in Journal of Clinical Anesthesia (2000), 12(5), 402-8

STUDY OBJECTIVES: To evaluate the efficacy of tropisetron, a selective 5-HT(3) receptor antagonist, in preventing nausea and vomiting in high-risk inpatients undergoing various surgical procedures. DESIGN ... [more ▼]

STUDY OBJECTIVES: To evaluate the efficacy of tropisetron, a selective 5-HT(3) receptor antagonist, in preventing nausea and vomiting in high-risk inpatients undergoing various surgical procedures. DESIGN: Prospective, open, nonrandomized, observational, interventional study. SETTING: Postanesthesia care unit, and surgical wards of the University Hospital Center, Charleroi. PATIENTS: A total of 1,132 elective surgical inpatients (>15 years of age) in two separate surveys. The first prospective survey covered all surgical adult inpatients (n = 671) after various surgical procedures over a 3-month period. A new 3-month survey was performed to assess the effectiveness of the preventive measure and included another 461 patients. INTERVENTIONS: Risk factors associated with nausea and vomiting were recorded in the first survey and used to establish an antiemetic policy. This consisted in the administration of tropisetron 2 mg intravenously after anesthesia induction, if two patient-related risk factors associated with high-risk surgery and general anesthesia were present. MEASUREMENTS AND MAIN RESULTS: Nausea frequency and intensity, assessed every 4 hours using a visual analog scale (VAS), frequency and times of vomiting episodes and the need for rescue medication were recorded for 72 hours postoperatively. Nausea was experienced by 18.8% and vomiting by 9.8% of the patients in the first survey (211 high risk-patients of 671). In the second survey, 137 patients of 461, considered at high-risk received prophylactic tropisetron. The proportion of patients having nausea decreased to 11.1% (p,178 0.01) and vomiting episodes to 2.8% (p < 0.001). Twenty-six of the tropisetron-treated patients (19%) suffered subsequent postoperative nausea and vomiting (PONV). Patient satisfaction with tropisetron was high. CONCLUSION: Prophylactic tropisetron can reduce the incidence of PONV in selected high-risk inpatients undergoing various types of surgical procedures. [less ▲]

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See detailInfluence of colors on habituation of visual evoked potentials in patients with migraine with aura and in healthy volunteers.
Afra, J; Ambrosini, A; Génicot, Roger ULg et al

in Headache (2000), 40(1), 36-40

OBJECTIVE: To investigate whether colored glasses influence the habituation of visual evoked potentials. BACKGROUND: We have previously shown that during pattern-reversal stimulations lasting 2 minutes ... [more ▼]

OBJECTIVE: To investigate whether colored glasses influence the habituation of visual evoked potentials. BACKGROUND: We have previously shown that during pattern-reversal stimulations lasting 2 minutes the amplitude of the visual evoked potential increases in migraine with and without aura between attacks, whereas it decreases in healthy volunteers. Red light was found to increase visually evoked EEG fast activity only in children with migraine with aura. Wearing rose-tinted glasses for 4 months decreased attack frequency in parallel with a reduction of the visually evoked EEG fast activity. METHODS: We compared the change in amplitude of the visual evoked potential using five different tinted glasses in 12 patients with migraine with aura and in 10 healthy volunteers. During continuous stimulation at 3.1 Hz, five blocks of 50 responses were sequentially averaged using red, yellow, green, blue, and grey glasses and without glasses in a random order and analyzed in terms of latencies and N1-P1 amplitudes. Amplitude changes were calculated for each block by comparison with the first block in every condition and analyzed statistically using Zerbe's method. RESULTS: In healthy volunteers, the visual evoked potential amplitude increased with red glasses compared to without glasses (P = .05) or with green glasses (P = .03). In patients with migraine with aura, no significant difference was detected using colored glasses. Our findings in healthy volunteers are in line with earlier reports of increased excitability of the human visual cortex when exposed to red light. The lack of such a pattern in patients with migraine with aura suggests that the visual cortex is interictally hypoexcitable rather than hyperexcitable, which is consistent with studies of transcranial magnetic stimulation. [less ▲]

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See detailTaurine and ethanol preference : a microdialysis study using Sardinian alcohol-preferring and non-preferring rats
Quertemont, Etienne ULg; Lallemand, Frédéric; Colombo, Giancarlo et al

in European Neuropsychopharmacology (2000), 10

Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the ... [more ▼]

Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the first 60-min period. In taurine-supplemented rats, a reduced aversion for high ethanol doses was observed in a place conditioning paradigm, suggesting that taurine may be implicated in the regulation of some adverse effects of ethanol. The present study compares the effects of acute ethanol injections (1.0 and 2.0 g/ kg, i.p.) on taurine nucleus accumbens microdialysate content in Sardinian ethanol-preferring (sP) and Sardinian ethanol-non preferring (sNP) rats. While neither saline nor 1.0 g/kg ethanol injections had significant effect on taurine microdialysate concentration, 2.0 g/kg ethanol administration induced a rapid and significant increase in taurine microdialysate content in both sP and sNP rats. However, this ethanol-induced taurine release was significantly reduced in sP rats by comparison to sNP rats. As taurine is suggested to be released by brain cells to modulate different ethanol adverse effects, this lower taurine responsiveness to ethanol in sP rats by comparison to both sNP and Wistar rats may be a relevant indicator of reduced ethanol aversive effects in such animals and therefore be related to their higher alcohol consumption. [less ▲]

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See detailConsidérations sur l'action en opposabilité d'un jugement étranger
Boularbah, Hakim ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2000)

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See detailBiocompatibility of polyethylene glycols (PEG): An approach using bovine serum albumin (BSA) as a protein model.
Loret, S; Gilson, P; Barakat, I et al

in Pflügers Archiv : European Journal of Physiology (2000), 440

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See detailHamstring muscle tear with recurrent complaints: An isokinetic profile
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Isokinetics & Exercise Science (2000), 8(3), 175-180

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See detailTraitement des myélomes réfractaires par la Thalidomide
Sautois, Brieuc ULg; Scerbo, Franca; Beguin, Yves ULg et al

in Médecine et Hygiène (2000), 58

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See detailComparison of visual and auditory evoked cortical potentials in migraine patients between attacks.
Afra, J.; Proietti Cecchini, A.; Sandor, P. S. et al

in Clinical Neurophysiology (2000), 111(6), 1124-9

OBJECTIVE: As both habituation of pattern reversal visual evoked potentials (PR-VEP) (Schoenen J, Wang W, Albert A, Delwaide PJ. Potentiation instead of habituation characterizes visual evoked potentials ... [more ▼]

OBJECTIVE: As both habituation of pattern reversal visual evoked potentials (PR-VEP) (Schoenen J, Wang W, Albert A, Delwaide PJ. Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks. Eur J Neurol 1995;2:115-122) and intensity dependence of auditory evoked cortical potentials (IDAP) (Wang W, Timsit-Berthier M, Schoenen J. Intensity dependence of auditory evoked potentials in migraine: an indication of cortical potentiation and low serotonergic neurotransmission? Neurology 1996;46:1404-1409) were found abnormal in migraine between attacks, we have searched for intraindividual correlations between both tests in 59 migraine patients (22 with aura [MA], 37 without aura [MO]) and in 23 healthy volunteers (HV). METHODS: Amplitude change of the PR-VEP N1-P1 was measured between the 1st and 5th block of 50 sequential averagings during continuous stimulation at 3.1 Hz. IDAP was computed from N1-P2 amplitudes of 100 averagings during stimulations at 40, 50, 60 and 70 dB SL. Amplitude-stimulus intensity function (ASF) slopes and amplitude changes between 40 and 70 dB were calculated. MO and MA differed from HV in PR-VEP amplitude change (P=0.007) and IDAP slope (P = 0.0004). RESULTS: There was no significant correlation between VEP amplitude changes and IDAP slopes, nor between the latter two and attack frequency or disease duration. A negative correlation was found between the amplitude of the first block of averaged responses and potentiation of VEP in all subject groups (P = 0.03) as well as between the amplitude of the auditory evoked potential, at 40 dB, and the percentage of amplitude increase between 40 and 70 dB in MO (P = 0.004) and MA (P = 0.007). ASF slopes and 40 dB amplitudes were significantly correlated only in the MA group (P = 0.002). These results confirm the interictal deficit of habituation in cortical processing of repetitive visual and auditory information in migraine. Since there is no intraindividual correlation between the cortical responses to these sensory modalities they are complementary tools for the study of migraine and may help to identify subgroups of patients with distinct pathophysiological mechanisms. CONCLUSIONS: The strong negative correlation between the initial amplitude of evoked potentials and their amplitude increase during subsequent averaging confirms that the response potentiation in migraine is likely to be due to a reduced preactivation level of sensory cortices. [less ▲]

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See detailRelationship between CNV topography and irritability in depression
Papart, Patrick ULg; WEERTS, Pascale ULg; Pinto, Emmanuel ULg et al

in Journal of Psychophysiology (2000), 14(Suppl 1),

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See detailCorrelation of the proposed Conodont based Upper Devonian substages boundary levels into the neritic and terrestrial Miospore zonation
Streel, Maurice ULg; Loboziak

in Newsletter. Subcommission on Devonian Stratigraphy (2000), 17

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See detailHydrodynamical and ecosystem processes in ice-covered seas of the Southern and Northern Hemispheres
Goffart, Anne ULg; Hecq, Jean-Henri ULg

in Journal of Marine Systems (2000), 27

Preface of the 30th International Liège Colloquium on Ocean Hydrodynamics Liège, Belgium (May 4–8 1998) : Hydrodynamical and ecosystem processes in ice-covered seas of the Southern and Northern ... [more ▼]

Preface of the 30th International Liège Colloquium on Ocean Hydrodynamics Liège, Belgium (May 4–8 1998) : Hydrodynamical and ecosystem processes in ice-covered seas of the Southern and Northern Hemispheres. Issue of JMS edited by Anne Goffart and Jean-Henri Hecq. [less ▲]

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See detailLa Forêt fossile d'Overlaar, Belgique (transition Paléocène-Eocène).
Gerrienne, Philippe ULg; Damblon, Freddy ULg; Fairon-Demaret, Muriel ULg et al

in Monografias Academia Ciencias, Exactas Fisicas, Quimicas y Naturales de Zaragoza (2000), 16

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See detailLe mélèze, une essence à haut potentiel de production
Pauwels, Dominique; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(3), 6-10

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze ... [more ▼]

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze méritait, à plusieurs égards, d'être davantage prise en compte en Région wallonne et ce, pour autant qu'une sylviculture adaptée à l'essence et aux conditions du milieu soit appliquée. Les lignes qui suivent sont consacrées à des résultats originaux résultant d'une étude menée par l'Unité de Gestion et Economie forestières de la Faculté universitaire des Sciences agronomiques de Gembloux, sur la croissance des mélèzes en Région wallonne. Le potentiel de croissance du mélèze a été évalué à partir d'analyses de tiges ou de mesures réalisées au sein de placettes de production (figure 1) remesurées tous les 3 ans. A partir d'une exploitation appropriée de ces données, on a déduit une gamme de traitements sylvicoles capables de rencontrer les objectifs de production que l'essence permet d'atteindre. [less ▲]

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See detailThe Emancipation of Women in Ancient Rome
Gerkens, Jean-François ULg; Vigneron, Roger

in Revue Internationale des Droits de l'Antiquité (2000), 47

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See detailCharacterization of two Acacia gums and their fractions using a Langmuir film balance
Fauconnier, Marie-Laure ULg; Blecker, Christophe ULg; Groyne, J. et al

in Journal of Agricultural and Food Chemistry (2000), 48(7), 2709-2712

The mechanical properties of monolayers from two Acacia gums [Acacia senegal (L.) Willd. and Acacia seyal Del.] and their three fractions isolated by hydrophobic interaction chromatography were studied ... [more ▼]

The mechanical properties of monolayers from two Acacia gums [Acacia senegal (L.) Willd. and Acacia seyal Del.] and their three fractions isolated by hydrophobic interaction chromatography were studied with a Langmuir film balance to obtain a more complete understanding of their action mode. The analysis of compression isotherms revealed that A. senegal gums globally exhibit better interfacial properties than A. seyal ones. The behavior of the whole gums appeared to be strongly influenced by their arabinogalactan-protein complex. [less ▲]

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See detailIdentification Of Key Residues For Interaction Of Vasoactive Intestinal Peptide With Human Vpac(1) And Vpac(2) Receptors And Development Of A Highly Selective Vpac(1) Receptor Agonist - Alanine Scanning And Molecular Modeling Of The Peptide
Nicole, P.; Lins, Laurence ULg; Rouyer-Fessard, C. et al

in Journal of Biological Chemistry (2000), 275(31), 24003-12

The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2). Solid-phase syntheses of VIP analogs in which each amino acid has been changed to alanine (Ala scan ... [more ▼]

The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2). Solid-phase syntheses of VIP analogs in which each amino acid has been changed to alanine (Ala scan) or glycine was achieved and each analog was tested for: (i) three-dimensional structure by ab initio molecular modeling; (ii) ability to inhibit (125)I-VIP binding (K(i)) and to stimulate adenylyl cyclase activity (EC(50)) in membranes from cell clones stably expressing human recombinant VPAC(1) or VPAC(2) receptor. The data show that substituting residues at 14 positions out of 28 in VIP resulted in a >10-fold increase of K(i) or EC(50) at the VPAC(1) receptor. Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor. The interaction of the analogs with human VPAC(2) receptor is similar to that observed with VPAC(1) receptor, with three remarkable exceptions: substitution of Thr(11) and Asn(28) by alanine increased K(i) for binding to VPAC(2) receptor; substitution of Tyr(22) by alanine increased EC(50) for stimulating adenylyl cyclase activity through interaction with the VPAC(2) receptor. By combining 3 mutations at positions 11, 22, and 28, we developed the [Ala(11,22,28)]VIP analog which constitutes the first highly selective (>1,000-fold) human VPAC(1) receptor agonist derived from VIP ever described. [less ▲]

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See detailNutrient depletions in the Ross Sea and their relation with pigment stocks
Goeyens, Leo; Elskens, Marc; Catalano, Giulio et al

in Journal of Marine Systems (2000), 27

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises ... [more ▼]

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises in the Ross Sea, two distinct groups were recognised. The first one was characterised by moderate nutrient nitrate and silicic acid depletions in combination with relatively high diatom and Phaeocystis abundance. The second group showed very low nutrient depletions and very poor diatom abundance. Average depth specific nitrate depletions were 8.1 and 1.1 μM and average silicic acid depletions were 21.5 and 1.3 μM, respectively. The nutrient consumption patterns did not match the conditions of silicic acid excess (SEA) or nitrate excess areas (NEA), a clear trend being probably obscured by very poor seasonal maturity of several sampling stations. The contrast between both groups is largely explained by small differences in nitrogen uptake regime of the major phytoplankters. During early season, the diatoms meet the majority of their nitrogen requirements by nitrate uptake, with few exceptions where ammonium is the most important nitrogenous substrate. On average, their nitrate uptake capacity is lower than that of Phaeocystis (average specific nitrate uptake rates were 0.021 and 0.036 day y-1 for diatoms and Phaeocystis, respectively). The latter phytoplankton always shows predominance of nitrate uptake. Both groups are subject to inhibition of nitrate uptake when ammonium availability increases, and it is likely that the diatoms are more sensitive to the inhibitory effect of ammonium. [less ▲]

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See detailDavid Malouf's 'Voyaging Imagination': The Conversations at Curlow Creek
Maes-Jelinek, Hena ULg

in Commonwealth : Essays and Studies (2000), 23(1), 89-98

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See detailFormes et formalités. Remarques sur la poétique du nom chez Mallarmé
Durand, Pascal ULg

in Formules (2000), 4

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See detailParticularités de la prise en charge de l’excès pondéral chez l’adolescent : résultats d’une enquête exploratoire
Glowacz, Fabienne ULg; Bourguignon, J. P.; Born, Michel ULg

in Bulletin d’Education du Patient (2000), 19(3), 132-140

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See detailPerturbed Proximal Point Algorithm with Nonquadratic Kernel
Brohé, Myrana; Tossings, Patricia ULg

in Serdica Mathematical Journal (2000), 26

Let H be a real Hilbert space and T be a maximal monotone operator on H. A well-known algorithm, developed by R.T. Rockafellar, for solving the problem "To find x in H such that 0 in Tx" is the proximal ... [more ▼]

Let H be a real Hilbert space and T be a maximal monotone operator on H. A well-known algorithm, developed by R.T. Rockafellar, for solving the problem "To find x in H such that 0 in Tx" is the proximal point algorithm. Several genaralizations have been considered by several authors: introduction of a perturbation, introduction of a variable metric in the perturbed algorithm, introduction of a pseudo-metric in place of the classical regularization, ... We summarize some of these extensions by taking into account a pseudo-metric as regularization and a perturbation in an inexact version of the algorithm. [less ▲]

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See detailBasic rules of dosimetry in endovascular brachytherapy.
Coucke, Philippe ULg; PHUOC DO, Hu; Pica, Alessia et al

in Journal of Interventional Cardiology (2000), 13(6), 425-429

Endovascular brachytherapy after percutaneous coronary intervention (PCI), is becoming a standard approach for the treatment and prevention of restenosis. A variety of technical approaches are currently ... [more ▼]

Endovascular brachytherapy after percutaneous coronary intervention (PCI), is becoming a standard approach for the treatment and prevention of restenosis. A variety of technical approaches are currently available to deliver ionizing irradiation to the vascular target. Basically two kinds of radioactive isotopes are available that emit gamma radiation (photons) or beta radiation (electrons). The pitfalls and solutions for the optimization of dosimetry are discussed. As might be expected, the inhomogeneous dose distribution across the target volume results in recurrence by underdosage or in complications because of overdosage. Moreover, uniformization of the target definition and reporting of the dose distribution in endovascular brachytherapy is a prerequisite for comparison between the results of the various clinical trials and is absolutely necessary to improve the therapeutic efficacy of this new approach in the prevention of restenosis after coronary angioplasty with or without stenting. (J Interven Cardiol2000; 13:425430) [less ▲]

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See detailFirst insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz, Marianne ULg; Van de Ven, W. J.; Kas, K.

in Advances in Dental Research (2000), 14

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10 ... [more ▼]

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is various translocations involving 12q15. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8q12. The most frequently encountered aberration in this group is a t(3;8)(p21;q12). [less ▲]

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See detailThe Bureaucracy of Crime : J. G. Ballard’s Cocaine Nights and the Speculative Thriller
Delville, Michel ULg

in Analele Universităţii Oradea - Seria Filologie, Fascicola Limba şi literatura (2000), 8

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See detailHeparin-coated Wiktor stents in human coronary arteries (MENTOR trial). MENTOR Trial Investigators.
Vrolix, M. C.; Legrand, Victor ULg; Reiber, J. H. et al

in The American journal of cardiology (2000), 86(4), 385-9

The purpose of this study was to determine the feasibility, safety, and efficacy of elective stenting with heparin-coated Wiktor stents in patients with coronary artery disease. In experimental studies ... [more ▼]

The purpose of this study was to determine the feasibility, safety, and efficacy of elective stenting with heparin-coated Wiktor stents in patients with coronary artery disease. In experimental studies, heparin coating has been shown to prevent subacute thrombosis and restenosis. Recently, a new method of heparin coating was developed, resulting in a more stable and predictable heparin layer on stent devices. This trial constitutes the first in-human use of this coating procedure, applied on the well-known Wiktor stent device. Heparin-coated Wiktor stent implantation was performed in 132 consecutive patients (132 lesions) in a multicenter international trial from September 1996 to February 1997. Forty-three percent of patients had unstable angina, 33% had previous myocardial infarction, and 10% had diabetes mellitus. Patients were followed for 12 months for occurrence of major adverse cardiovascular events, and 96% of the eligible patients underwent quantitative angiographic control at 6 months. Stent deployment was successful in 95.5% of lesions. Minimal lumen diameter increased by 1.67 +/- 0.48 mm (from 1.02 +/- 0.38 mm before to 2.69 +/- 0.37 mm after the stent implantation). Mean percent diameter stenosis decreased from 67.4 +/- 11.3% before to 18.9 +/- 7.7% after the intervention. A successful intervention (<50% diameter stenosis and no major adverse cardiac events within 30 days) occurred in 97% of the patients. The subacute thrombosis rate was 0.8%, which compares favorably with historical controls of this stent, and a low incidence of postprocedural increase in creatine kinase-MB was noted. At 6 months, event-free survival was 85% and angiographic restenosis rate was 22% with late loss of 0.78 +/- 0.69 mm and a loss index of 0.48 +/- 0.44. Heparin-coated Wiktor stents appeared to be an efficacious device to treat Benestent-like lesions, yielding angiographic and clinical results comparable to a heparin-coated Palmaz-Schatz stent. Despite its use in more complex lesions, the incidence of subacute thrombosis appeared to be lower than historical controls with a similar noncoated stent. [less ▲]

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See detailPrincipal component analysis based on robust estimators of the covariance or correlation matrix: Influence functions and efficiencies
Croux, C.; Haesbroeck, Gentiane ULg

in Biometrika (2000), 87(3), 603-618

A robust principal component analysis can be easily performed by computing the eigenvalues and eigenvectors of a robust estimator of the covariance or correlation matrix. In this paper we derive the ... [more ▼]

A robust principal component analysis can be easily performed by computing the eigenvalues and eigenvectors of a robust estimator of the covariance or correlation matrix. In this paper we derive the influence functions and the corresponding asymptotic variances for these robust estimators of eigenvalues and eigenvectors. The behaviour of several of these estimators is investigated by a simulation study. It turns out that the theoretical results and simulations favour the use of S-estimators, since they combine a high efficiency with appealing robustness properties. [less ▲]

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See detailL'antibiothérapie en néonatalogie: mise-au-point
Langhendries, JP; Kalenga, Masendu ULg; Battisti, Oreste ULg et al

in Journal du Pédiatre Belge (2000), 2

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See detailLa prescription des pensions alimentaires allouées par décision de justice. Note sous Liège, 18 octobre 1999
Kohl, Benoît ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2000)

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See detailApproches thérapeutiques du cancer ovarien
Bonnet, Christophe ULg; Jerusalem, Guy ULg; Bours, Vincent ULg et al

in Médecine et Hygiène (2000), 58

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See detailDexamethasone Ester Treatment Alters Insulin-Like Growth Factor-I, Its Binding Proteins And Thyroid Status In Finishing Calves
Bertozzi, C.; Portetelle, Daniel ULg; Massart, Serge et al

in Canadian Journal of Animal Science (2000), 80(2),

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See detailApprendre à résoudre des équations
Demonty, Isabelle ULg; Vlassis, Joëlle ULg

in informations pé (2000), 50

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See detailClinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantation.
Baron, Frédéric ULg; Gothot, André ULg; Salmon, Jean ULg et al

in British Journal of Haematology (2000), 111(3), 745-53

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome ... [more ▼]

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome, termed autologous GVHD has notable anti-tumour activity in animal studies. We intended to induce autologous GVHD with CyA in patients undergoing an autologous HSCT. We prospectively studied 118 patients with miscellaneous malignancies undergoing an autologous HSCT with low-dose CyA to characterize the clinical syndrome, its frequency and clinical course, and to determine the factors affecting its incidence. Patients received CyA from d -1 through to d 28, first starting at 2 mg/kg intravenously and then orally as soon as feasible. The dose was adjusted to achieve pre-dose blood levels around 100 ng/ml. A skin biopsy was performed when a skin rash was observed. Thirty-three percent of the patients developed clinical GVHD: clinical stage 1 in 21 patients, stage 2 in seven patients, and stage 3 in three patients. Although total body irradiation (TBI) or high-dose cyclophosphamide were previously thought to be needed, autologous GVHD occurred in five out of 12 patients (42%) after a preparative regimen with high-dose melphalan alone. Autologous GVHD was significantly more frequent in patients older than 33 years, in patients who had received high doses of granulocyte-macrophage colony forming units (CFU-GM) and in those with a diagnosis of myeloid malignancy, compared with those with lymphoid malignancies or solid tumours. A significant negative association was also found with HLA-DR6. In lymphoma patients, GVHD occurred more frequently in advanced disease than in first or second complete remission (CR1-2) patients. All other factors studied were not predictive for GVHD. In conclusion, CyA-induced GVHD is reproducibly and safely induced with doses of CyA adapted to achieve blood levels around 100 ng/ml. In retrospective analysis, there was no survival advantage for patients with GVHD. Phase III trials with this approach are needed to evaluate its anti-tumoral effect. [less ▲]

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See detailA further locality with foliicolous lichens in Italy, with taxonomical and ecological data on foliicolous lichens in Western Europe
Puntillo, Domenico; Bricaud, Olivier; Sérusiaux, Emmanuël ULg

in Cryptogamie. Mycologie (2000), 21

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See detailMicro-phonochirurgie assistée au laser CO2 des lésions bénignes des cordes vocales
Remacle, Marc; Giovanni, Antoine; Lawson, George et al

in Cahiers d'Oto-rhino-laryngologie, de Chirurgie Cervico-faciale et d'Audiophonologie (Les) (2000), 35(6), 293-300

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See detailExperimental and theoretical radiative lifetimes, branching fractions, and oscillator strengths for Lu I and experimental lifetimes for Lu II and Lu III
Fedchak, J. A.; Den Hartog, E. A.; Lawler, J. E. et al

in Astrophysical Journal (2000), 542

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See detailA clinical comparison of sumatriptan nasal spray and dihydroergotamine nasal spray in the acute treatment of migraine.
Boureau, F.; Kappos, L.; Schoenen, Jean ULg et al

in International Journal of Clinical Practice (2000), 54(5), 281-6

A multinational, multicentre, randomised, double-blind, double-dummy, crossover study (368 patients treating two attacks) was conducted to compare the efficacy and tolerability of sumatriptan nasal spray ... [more ▼]

A multinational, multicentre, randomised, double-blind, double-dummy, crossover study (368 patients treating two attacks) was conducted to compare the efficacy and tolerability of sumatriptan nasal spray (20 mg) with dihydroergotamine (DHE) nasal spray (1 mg plus optional 1 mg). At the primary efficacy time point of 60 minutes after dosing, significantly more patients obtained headache relief (change from moderate or severe to none or mild) after treatment with sumatriptan than with DHE (53% sumatriptan, 41% DHE, p < 0.001). Significantly more patients reported relief of nausea after sumatriptan than after DHE at 60 minutes (64% sumatriptan, 49% DHE, p = 0.006). A significant difference between the two treatments was first observed at 45 minutes with respect to both headache relief (38% sumatriptan, 31% DHE, p = 0.037) and relief of nausea (55% sumatriptan, 40% DHE, p = 0.014). There were no significant differences between the two treatments for other measures of efficacy. Both treatments were well tolerated, with only 10% of patients in each group reporting one or more adverse events. The most frequently reported adverse event after sumatriptan was a bad or bitter taste, which was reported by 5% of patients. After DHE, 4% of patients reported symptoms of the nasal cavity/sinuses and 3% reported nausea and/or vomiting as adverse events. It is concluded that sumatriptan nasal spray is superior to DHE nasal spray in the relief of pain and nausea associated with acute migraine headache. [less ▲]

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See detailSeismic hazard in the Sea of Marmara following the Izmit Earthquake
Hubert, Aurelia ULg; Barka, Aykut; Jacques, Eric et al

in Nature (2000), 404

On 17 August 1999, a destructive magnitude 7.4 earthquake occurred 100 km east of Istanbul, near the city of Izmit, on the North Anatolian fault. This 1,600-km-long plate boundary1,2 slips at an average ... [more ▼]

On 17 August 1999, a destructive magnitude 7.4 earthquake occurred 100 km east of Istanbul, near the city of Izmit, on the North Anatolian fault. This 1,600-km-long plate boundary1,2 slips at an average rate of 2–3 cm yr−1 (refs 3–5), and historically has been the site of many devastating earthquakes6,7. This century alone it has ruptured over 900 km of its length6. Models of earthquake-induced stress change8 combined with active fault maps9 had been used to forecast that the epicentral area of the 1999 Izmit event was indeed a likely location for the occurrence of a large earthquake9,10. Here we show that the 1999 event itself significantly modifies the stress distribution resulting from pre- vious fault interactions9,10. Our new stress models take into account all events in the region with magnitudes greater than 6 having occurred since 1700 (ref. 7) as well as secular interseismic stress change, constrained by GPS data11. These models provide a consistent picture of the long term spatio–temporal behaviour of the North Anatolian fault and indicate that two events of magnitude equal to, or greater than, the Izmit earthquake are likely to occur within the next decades beneath the Marmara Sea, south of Istanbul. [less ▲]

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See detailCyanures et thiocyanates en toxicologie hospitalière
Charlier, Corinne ULg; Gougnard, Th; Lamiable, D. et al

in Annales de Toxicologie Analytique (2000), XII(2), 131-136

Cyanide is a highly toxic poison, able to very rapidly induce the death. Thiocyanate anion (SCN-) is a metabolic product of cyanide and cyano-containing organic substances, produced by two major enzymes ... [more ▼]

Cyanide is a highly toxic poison, able to very rapidly induce the death. Thiocyanate anion (SCN-) is a metabolic product of cyanide and cyano-containing organic substances, produced by two major enzymes : thiosulfate sulfure transferase and β mercaptopyruvate transsulfurase. Determinations of blood cyanide is important to confirm the diagnostic of intoxication. A survey of methods for the quantitative determination of cyanide and thiocyanate in biological matrices is presented. Particular attention is paid to the rapidity and to the sensitivity of the method. [less ▲]

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See detailRespiratory responses of mature horses to intravenous lobeline bolus
Marlin, D. J.; Roberts, C. A.; Schroter, R. C. et al

in Equine Veterinary Journal (2000), 32(3), 200-207

The respiratory stimulant lobeline has been used in equine clinical practice to increase inspiratory and expiratory airflow rates at rest in orderto facilitate investigation of both lower and upper airway ... [more ▼]

The respiratory stimulant lobeline has been used in equine clinical practice to increase inspiratory and expiratory airflow rates at rest in orderto facilitate investigation of both lower and upper airway function. Some of the responses to lobeline in the pony have been reported, but the detailed time course, effect of dose, possible side effects and reproducibility associated with lobeline administration have not been described in the horse. Respiratory airflow rates and oesophageal pre s s u re were measured with a Fleisch No. 5 pneumotachometer and lightweight facemask and amicrotip pressure transducer catheter, respectively. The output of the Fleisch pneumotachometer was calibrated for flow rates up to ± 70 l/s. Seven mature horses with no clinical signs of respiratory disease were studied. Investigations were conducted to determine: (1) the responses to different doses of lobeline (0.15, 0.20, 0.25 and 0.30 mg/kg bwt) as a rapid i.v. bolus (6 horses); (2) arterial blood gases during and after lobeline administration (0.20 mg/kg bwt; 3 horses); and (3) the reproducibility of lobeline-stimulated hyperpnoea (5 horses; 2 doses of 0.20 mg/kg bwt lobeline, 15 min apart). All horses tolerated the lobeline-stimulated hyperpnoea well, although one always coughed or snorted at the onset. Mild tremor was noted following the highest dose in several horses. Apnoea of approximately 40 s was common after the hyperpnoea. Both tidal volume (VT) and frequency (fR) increased with lobeline dose. During peak hyperpnoea at a dose of 0.30 mg/kg bwt, peak inspired flow rate (PIF), peak expired flow rate (PEF) and minute ventilation (.VE) were mean ± s.e. 41 ± 5 l/s, 61 ± 10 l/s and 920 ± 99 l/min, respectively. The hyperpnoea also caused marked changes in arterial PaO2, PaCO2 and pHa at 90 s after lobeline (0.20 mg/kg bwt) administration (mean ± s.e. 146.0 ± 6.9 mmHg, 20.6 ± 0.8 mmHg and 7.707 ± 0.020, respectively) compared to at rest (mean ± s.e. 104.0 ± 4.0 mmHg, 50.6 ± 2.8 mmHg and 7.432 ± 0.012). Dynamic lung compliance (Cdyn) was unaltered by lobeline administration. The lobeline-induced hyperpnoea was highly reproducible, with no significant difference in any of the parameters during 2 stimulations 15 min apart. Lobeline induced highly reproducible responses without any apparent adverse effects and may be useful in the investigation of pulmonary function in healthy horses and those with airway disease. [less ▲]

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See detailThe cerebral protective effect of anaesthetics
HANS, Pol; BONHOMME, Vincent ULg

in Current Anaesthesia and Critical Care (2000), 11

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See detailCurrent and future trends in groundwater vulnerability assessment
Gogu, Radu; Dassargues, Alain ULg

in Environmental Geology (2000), 39(6), 549-559

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have ... [more ▼]

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have failed to reach a consensus concerning the definitions of and reference terms for groundwater vulnerability assessment. Therefore, a review of vulnerability assessment and mapping methods providing a new classification system is necessary. This is focused on techniques that use the overlay and index class methods. New research challenges in vulnerability assessment are identified, especially the need for developing dynamic links between numerical models and overlay and index methods. [less ▲]

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See detailLe courant excito-moteur: aspects scientifiques et rééducatifs
Vanderthommen, Marc ULg

in Kine Acta (2000), 356

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See detailTraitement médical des colites aiguës inflammatoires sévères
Belaiche, Jacques ULg; Louis, Edouard ULg

in Hépato-Gastro (2000), 7

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See detailMechanical properties of Al/Al2O3 nanolaminated films: correlation to microstructure
Ben Daia, M.; Aubert, P.; Labdi, S. et al

in Surface & Coatings Technology (2000), 125(1-3), 196-200

Wear resistance and the hardness of Al/Al2O3 nanolaminated films were investigated in this study. Monolithic films and multilayers were deposited on a silicon substrate with two different substrate ... [more ▼]

Wear resistance and the hardness of Al/Al2O3 nanolaminated films were investigated in this study. Monolithic films and multilayers were deposited on a silicon substrate with two different substrate temperatures: T-s= 25 degrees C and T-s= -90 degrees C. The period thickness of multilayers was lowering from 40 to 2 nm. From nanoindentation measurements, it appears that the hardness of multilayers has an intermediate value between those of metal (Al) and ceramic (Al2O3). The tribological test was conducted by the pin-on-disc method. The T-s=25 degrees C deposited multilayers, as well as single films, demonstrated poor wear resistance. The best wear resistance was obtained for multilayers deposited at the lowest substrate temperature (T-s= -90 degrees C). The results are ill good agreement with structural characterization. X-ray reflectometry demonstrated that the multilayer character of Al/Al2O3 is more pronounced for T-s= -90 degrees C. (C) 2000 Elsevier Science S.A. All rights reserved. [less ▲]

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See detailDifferences in associations of familial and nutritional factors with serum lipids between boys and girls: the Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Lambert, A.

in American Journal of Clinical Nutrition (2000), 72(2), 384-8

BACKGROUND: Sex differences in the effects of genetic and environmental factors on circulating lipids have been examined mainly in adults, in whom the influences of sex steroid hormones are well known ... [more ▼]

BACKGROUND: Sex differences in the effects of genetic and environmental factors on circulating lipids have been examined mainly in adults, in whom the influences of sex steroid hormones are well known. OBJECTIVE: Our objective was to determine the effect of sex on genetic and environmental influences on serum lipids in prepubertal boys and girls. DESIGN: Children aged 6-8, 8-10, and 10-12 y (n = 1028) were selected at random in the Belgian province of Luxembourg, a region in Europe with a high prevalence of risk factors for cardiovascular disease and diabetes. Blood glucose and serum cholesterol, triacylglycerol, and insulin concentrations were measured, and anthropometric data and blood pressure were recorded. Familial data were obtained from standardized questionnaires. Nutritional status was obtained from a 3-d record. Participation was 70.3% of the primary cohort. RESULTS: Cholesterol, triacylglycerol, and insulin values were among the highest recorded in studies of children. In girls, cholesterol correlated positively with the energy density of intake of saturated fat (r = 0.13, P = 0.001), cholesterol (r = 0.11, P = 0.006), and protein (r = 0.12, P = 0.007) and negatively with the ratio of polyunsaturated to saturated fat intake (r = -0.14, P = 0.001) and the energy density of carbohydrate intake (r = -0.11, P = 0.019). In boys, no such relations were found. Triacylglycerol was not significantly related to nutritional factors. Consistent, independent relations were found between reported elevated cholesterol concentrations in the parental and grandparental generation and cholesterol (r = 0.101, P = 0.011) and triacylglycerol (r = 0.09, P = 0.03) in boys. No such associations were found in girls. CONCLUSION: Environmental and genetic factors may have different effects on serum cholesterol in girls and boys. [less ▲]

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See detailLa querelle judiciaire au sujet de l'indemnité forfaitaire en faveur de l'ONSS
Kefer, Fabienne ULg

in Journal des Tribunaux du Travail (2000)

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See detailConsequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
Kutter, D.; Devaquet, P.; Vanderstocken, G. et al

in Acta Haematologica (2000), 104(1), 10-5

A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency ... [more ▼]

A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated. [less ▲]

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See detailWanze/Huccorgne : la grotte du Docteur
Miller, Rebecca ULg; Otte, Marcel ULg

in Chronique de l'Archéologie Wallonne (2000), 8

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See detailDes astres à l'atome, de l'atome aux astres
Biémont, Emile ULg

in Lettre du FNRS (2000), 41

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See detailBactériologie comparée des liquides de lavage pulmonaire obtenus par voie transtrachéale ou par voie nasotrachéale chez le veau
Schreiber, P.; Thomas, A.; Linden, Annick ULg et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailHeadache tutorial.
Russell, M. B.; Nielsen, K. D.; Rasmussen, C. et al

in Studies in Health Technology & Informatics (2000), 78

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and ... [more ▼]

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and nomenclature. It is possible to move between the modules both vertically and horizontally. This paper concerns the headache tutorial. It consist of case records that the user can test his diagnostic abilities on. Each case record is subdivided into an interview by the physician, physical and neurological examination, laboratory test, sum of positive diagnostic elements, suggestions of diagnoses and management. A total of 12 case records are provided. The system will be available on a CD-ROM. [less ▲]

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See detailNew f values in neutral lead obtained by time-resolved laser spectroscopy, and astrophysical applications
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Palmeri, P. et al

in Monthly Notices of the Royal Astronomical Society (2000), 312

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See detailConvergentie en divergentie in de Nederlandse standaardtaal. Het stripverhaal Suske en Wiske als casus.
Meesters, Gert ULg

in Nederlandse Taalkunde (2000), 5(2), 164-176

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See detailNanoindentation investigation of Ti/TiN multilayers films
Ben Daia, M.; Aubert, P.; Labdi, S. et al

in Journal of Applied Physics (2000), 87(11), 7753-7757

The hardness of Ti/TiN nanolaminated films is investigated in this study. Monolithic Ti and TiN films and Ti/TiN multilayers were deposited on silicon substrates by radio-frequency sputtering. The period ... [more ▼]

The hardness of Ti/TiN nanolaminated films is investigated in this study. Monolithic Ti and TiN films and Ti/TiN multilayers were deposited on silicon substrates by radio-frequency sputtering. The period thickness of multilayers was decreased from 20 to 2.5 nm. Grazing x-ray reflectometry showed that the modulation of composition of Ti/TiN multilayers exists for all the period thickness considered. From nanoindentation measurements, we determined the hardness and Young's modulus of multilayers. Hardness increased with decreasing period thickness to go beyond the rule-of-mixture value for samples with period thickness of Lambda less than or equal to 5 nm. The maximum hardness, 1.6 times higher than the value obtained by the rule of mixture, is obtained for Lambda=2.5 nm. Our results are compared to a dislocation-based model previously introduced by Lehoczky. (C) 2000 American Institute of Physics. [S0021-8979(00)09411-1]. [less ▲]

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See detailLe point des connaissances sur les entérites à Escherichia coli chez le veau
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2000), 144

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See detailResults of the tracer tests during the El Tremedal underground coal gasification at great depth
Pirard, Jean-Paul ULg; Brasseur, Alain; Coeme, Antoinette et al

in Fuel (2000), 79(5), 471-478

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases ... [more ▼]

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases progressively with the cumulated quantity of oxygen injected. Models based on exchange of matter between the flowing fluid and a transverse dead zone were used. Results indicate that the gasifier behaves almost like a small number of stirred tanks in series with a high level of back mixing. (C) 2000 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPsychiatrie en osteoporose
Halkin, V; Reginster, Jean-Yves ULg

in Agenda Psychiatrie (L') (2000), 14

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See detailLittératures post-coloniales anglophones : tradition et originalité
Maes-Jelinek, Hena ULg

in Bulletin de la Classe des Lettres et des Sciences Morales et Politiques (2000), 11(7-12), 437-455

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See detailSurveillance thérapeutique des traitements anticancéreux
Gougnard, Th; Charlier, Corinne ULg; Plomteux, Guy ULg

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2000), 15(4), 258-261

Drug monitoring of anticancer chemotherapies.Drug doses used in anticancer treatments are mostly calculated by the use of clinical criteria, sometimes by using nomograms providing a posology based on the ... [more ▼]

Drug monitoring of anticancer chemotherapies.Drug doses used in anticancer treatments are mostly calculated by the use of clinical criteria, sometimes by using nomograms providing a posology based on the body surface area (BSA) but rarely by taking into account classical pharmacokinetic parameters, as usually for optimizing the treatment with other pharmaceutical classes of drugs (antibiotics, antiepileptics,…). Because the narrow therapeutic index and important intra- and interindividual variations of the pharmacokinetic parameters, anticancer drugs could constitute a pharmacological class for which the posology could be defined by a classical therapeutic drug monitoring. Of course, the determination of the plasmatic level of anticancer drug does not always permit to predict their pharmacological efficacy and toxicity. To reach it, it is necessary to calculate the area under the curve obtained on base of several blood concentrations. [less ▲]

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See detailVibrational Structure and Organization of Various Self-Assembled Alkanethiol Monolayers: a HREELS Study
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Langmuir (2000), 16

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R ... [more ▼]

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R-cycloalkyl-ö-alkanethiols on different gold substrates. The HREELS data are reported as a contribution to a general effort to assess the potential of electron spectroscopies in the elucidation of structural characteristics of organic surfaces. Typical fingerprints of the thiol molecules, characteristic of their primary and secondary structure (connectivity, conformation, and order), have been found in their HREELS vibrational spectra. We have shown that when the layers are disordered, the spectra are dominated by impact-excited modes, hampering the identification of the compounds. These data have evidenced many defects in the organization of the monolayers on evaporated gold substrates. The coherent domains sizes formed by the molecules in the films have been estimated from the angular distribution of the elastic peak as a function of the nature of the alkanethiol chain and of the immersion time in thiol solutions [less ▲]

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See detailRisedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group.
Fogelman, I; Ribot, C; Smith, R et al

in Journal of Clinical Endocrinology and Metabolism (2000), 85(5), 1895-900

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months ... [more ▼]

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months of placebo or risedronate (2.5 or 5 mg/day). All received calcium (1 g/day). The principal outcome measures were bone mineral density (BMD) at the lumbar spine, femoral neck, and femoral trochanter. At 24 months, lumbar spine BMD increased from baseline by 4% with 5 mg risedronate and 1.4% in the 2.5-mg group, compared with no change with placebo. Efficacy was similar in women who were less than 5 yr and more than 5 yr postmenopausal. At 24 months, risedronate (5 mg) had also increased BMD at the femoral neck and trochanter, whereas BMD decreased in the placebo group. BMD increases were seen at all three sites with risedronate (5 mg) after only 6 months of therapy. Risedronate was well tolerated; upper gastrointestinal adverse events were similar to placebo. We conclude that risedronate (5 mg) increases BMD rapidly and effectively and is well tolerated in postmenopausal women with low bone mass, regardless of time since menopause. [less ▲]

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See detailHarcèlement moral au travail. Etat des lieux et pistes de développement.
Faulx, Daniel ULg; Geuzaine, Caroline

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2000), 37(3), 135-147

Revue théorique critique et analyse de littérature sur le harcèlement moral

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See detailBauhinia L. in the Philippine Islands: aspects of diversity and vegetation units
Ruelle, S.; Malaisse, François ULg

in Geo-Eco-Trop (2000), 23(1-4), 49-62

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See detailSm-Nd isotope systematics in deep-sea sediments: clay-size versus coarser fractions
Innocent, C.; Fagel, Nathalie ULg; Hillaire-Marcel, C.

in Marine Geology (2000), 168(1-4), 79-87

Sm-Nd studies were carried out on Last Glacial and Holocene sediments from the Labrador Sea. Three grain-size fractions were analyzed for each sediment: the clay-size fraction (<2 mu m), the fine cohesive ... [more ▼]

Sm-Nd studies were carried out on Last Glacial and Holocene sediments from the Labrador Sea. Three grain-size fractions were analyzed for each sediment: the clay-size fraction (<2 mu m), the fine cohesive silts (2-10 mu m) and the coarse silts (10-63 mu m) In most cases, Sm-Nd signatures are different from one grain-size to another. In addition, different Sm-Nd signatures are derived from the clay-size fractions compared to the cohesive silt fraction, indicating that the cohesive fraction is heterogeneous and that distinct origins in terms of source-areas are implied. Silt fractions record the influence of supplies from the North American Precambrian Shield, whereas clay-size fractions (<2 mu m) are more sensitive to sedimentary input from the Eastern Basins, in relation with deep currents. Coupling Sm-Nd studies on silt and clay fractions may be a powerful tool to unravel the evolution of deep circulations versus detrital supplies. (C) 2000 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailAb initio study of organic mixed valency
Dehareng, Dominique ULg; Dive, Georges ULg; Moradpour, Alec

in International Journal of Quantum Chemistry (2000), 76(4), 552-573

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by ... [more ▼]

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by full geometry optimization At both nuclear arrangements, mostly found as being minima in the symmetry-restrained Hartree-Fock framework, excitation energies were calculated through the expansion of the wave function on single electronic excitations of the Hart ee-Fock fundamental determinant and at the unrestricted Hartree-Fock or at the multiconfigurational self consistent field levels. Few calculations were also performed by taking into account some part of the electronic correlation. Except for N,N,N',N'-tetramethyl p-phenylenediamine, all the studied compounds are localized stable cations, at the symmetry-restrained Hartree-Fock level. However, the reoptimization of their wave function changes this observation since only three of them seem to conserve a localized stable conformation. Most of the studied systems are characterized by one or two excited electronic states very dose to the fundamental one and should thus present an unresolved broadened first absorption band in the near-infrared region These features are in agreement with the available experimental data. Strong Hartree-Fock instabilities are found for the delocalized structure and put in relation with the existence of the large nonadiabatic coupling in this conformational region. The solvent influence is discussed in the Onsager dipolar reaction field framework. (C) 2000 John Wiley & Sons, Inc. [less ▲]

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See detailLe Sart Tilman et Louvain-la-Neuve
Frankignoulle, Pierre ULg

in Cahiers de l'Urbanisme (Les) (2000), 28-29

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See detailThe unseen face of humanitarian crisis in eastern Democratic Republic of Congo: was nutritional relief properly targeted?
Porignon, Denis ULg; Katulanya, I.; Elongo, L. et al

in Journal of epidemiology and community health (2000), 54(1), 6-9

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic ... [more ▼]

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic Republic of Congo. DESIGN: Cross sectional surveys. SETTING: Temporary and other settlements, in the town of Goma and surrounding rural areas. SUBJECTS: Anthropometric indicators of nutritional status and presence or absence of oedema were measured among 5121 children aged 6 to 59 months recruited by cluster sampling with probability proportional to size, between June and August 1995. RESULTS: Children in all locations demonstrated a typical pattern of growth deficit relative to international reference. Prevalence of acute malnutrition (wt/ht < -2 Z score) was higher among children in the rural non-refugee populations (3.8 and 5.8%) than among those in the urban non-refugee populations (1.4%) or in the refugee population living in temporary settlements (1.7%). Presence of oedema was scarcely noticed in camps (0.4%) while it was a common observation at least in the most remote rural areas (10.1%). As compared with baseline data collected in 1989, there is evidence that nutritional status was worsening in rural non-refugee populations. CONCLUSIONS: Children living in the main town or in the refugee camps benefited the most from nutritional relief while those in the rural non-refugee areas were ignored. This is a worrying case of inequity in nutritional relief. [less ▲]

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See detailA comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses
Raisis, Anthea L; Young, L. E.; Blissitt, K. J. et al

in Equine Veterinary Journal (2000), 32(4), 318-326

The purpose of this study was to compare the haemodynamic effects of equipotent isoflurane and halothane anaesthesia. Six adult horses were investigated on two separate occasions at least 4 weeks apart ... [more ▼]

The purpose of this study was to compare the haemodynamic effects of equipotent isoflurane and halothane anaesthesia. Six adult horses were investigated on two separate occasions at least 4 weeks apart. On both occasions anaesthesia was induced by ketamine 2.2 mg/kg bwt given 5 min after i.v. administration 100 microg/kg bwt romifidine. Anaesthesia was maintained either by halothane or isoflurane (end-tidal concentrations 0.9-1.0% and 1.3-1.4%, respectively). Horses were ventilated by intermittent positive pressure to maintain PaCO2 between 40-50 mmHg. Haemodynamic variables were measured using catheter-mounted strain gauge transducers in the left and right ventricle, aorta, and right atrium. Cardiac output (CO), velocity time integral (VTI), maximal aortic blood flow velocity (Vmax) and acceleration (dv/dt(max)), left ventricular pre-ejection period (PEP) and ejection time (ET) were measured from aortic blood flow velocity waveforms obtained by transoesophageal Doppler echocardiography. Flow velocity waveforms were recorded from the femoral arteries and veins using low pulse repetition frequency Doppler ultrasound. Time-averaged mean velocity (TAV), velocity of component a (TaVa), velocity of component b (TaVb) and early diastolic deceleration slope (EDDS) were measured. Pulsatility index (PI) and volumetric flow were calculated. Microvascular blood flow was measured in the left and right semimembranosus muscles by laser Doppler flowmetry. Maximal rate of rise of LV pressure (LVdp/dt(max)), CO, Vmax, dv/dt(max), ET, VTI were significantly higher at all time points during isoflurane anaesthesia compared to halothane anaesthesia. Pre-ejection period and diastolic aortic blood pressure were significantly less throughout isoflurane anaesthesia compared to halothane. Isoflurane anaesthesia was associated with significantly lower systemic vascular resistance than halothane anaesthesia. Femoral arterial and venous blood flow were significantly higher and EDDS and PI were significantly lower during isoflurane anaesthesia compared to halothane anaesthesia. In addition during both halothane and isoflurane anaesthesia, femoral arterial flow was higher and EDDS and PI lower in the left (dependent) artery compared to the right (nondependent) artery. This study supports previous work demonstrating improved left ventricular systolic function during isoflurane compared to halothane anaesthesia. This improvement was still evident after premedication with a potent-long acting alpha2-adrenoreceptor agonist, romifidine, and induction of anaesthesia with ketamine. There was also evidence of increased hindlimb blood flow during isoflurane anaesthesia. However, there were differences observed in flow between the left and right hindlimb during maintenance of anaesthesia with each agent, suggesting that there were differences in regional perfusion in anaesthetised horses caused by factors unrelated to agents administered [less ▲]

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See detailLe capital osseux : une épargne qui débute au berceau
Halkin, V; Reginster, Jean-Yves ULg

in L'agenda Pédiatrie (2000), 22

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See detailHuitième campagne de fouilles à Tell Beydar
Van der Stede, Véronique ULg; Talon, Philippe

in Annales d'Histoire de l'Art et d'Archéologie (2000), XXII

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See detailLa probatio internetica
Vanbrabant, Bernard ULg

in Actualités du Droit (2000)

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See detailSilencing subdomains of v-ErbA interact cooperatively with corepressors: involvement of helices 5/6
Busch, Kerstin; Martin, Bernd; Baniahmad, Aria et al

in Molecular Endocrinology (Baltimore, Md.) (2000), 14(2), 201-11

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression ... [more ▼]

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression by TR in the absence of ligand is mediated by an active silencing mechanism. The oncogene v-ErbA is a variant form of TR unable to bind hormone and thus acts as a constitutive repressor. Functional studies and mutation analysis revealed that the TR/v-ErbA silencing domain is composed of three silencing subdomains (SSD1-3) which, although nonfunctional individually, synergize such that silencing activity is restored when they are combined in a heteromeric complex. Here we demonstrate, using protein interaction assays in vitro and in vivo, that the inactive v-ErbA point mutant L489R within helix 5/6 in SSD2 fails to interact with the two corepressors N-CoR (nuclear receptor corepressor) or SMRT (silencing mediator of retinoic acid and thyroid hormone receptor). Furthermore, mutants in SSD1 and SSD3 exhibit a reduced corepressor recruitment corresponding to their weak residual silencing activity. In mammalian two-hybrid assays, only the combination of all three silencing subdomains, SSD1-3, leads to a cooperative binding to the corepressors N-CoR or SMRT comparable to that of the full-length v-ErbA repression domain. In conclusion, full silencing activity requires corepressor interaction with all three silencing subdomains, SSD1-3. Among these, SSD2 is a new target for N-CoR and SMRT and is essential for corepressor binding and function. [less ▲]

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See detailMajor histocompatibility complex class II expression by activated microglia caudal to lesions of descending tracts in the human spinal cord is not associated with a T cell response.
Schmitt, A. B.; Buss, A.; Breuer, S. et al

in Acta Neuropathologica (2000), 100(5), 528-36

Lesion-induced microglial/macrophage responses were investigated in post-mortem human spinal cord tissue of 20 patients who had died at a range of survival times after spinal trauma or brain infarction ... [more ▼]

Lesion-induced microglial/macrophage responses were investigated in post-mortem human spinal cord tissue of 20 patients who had died at a range of survival times after spinal trauma or brain infarction. Caudal to the spinal cord injury or brain infarction, a strong increase in the number of activated microglial cells was observed within the denervated intermediate grey matter and ventral horn of patients who died shortly after the insult (4-14 days). These cells were positive for the leucocyte common antigen (LCA) and for the major histocompatibility complex class II antigen (MHC II), with only a small proportion staining for the CD68 antigen. After longer survival times (1-4 months), MHC II-immunoreactivity (MHC II-IR) was clearly reduced in the grey matter but abundant in the white matter, specifically within the degenerating corticospinal tract, co-localising with CD68. In this fibre tract, elevated MHC II-IR and CD68-IR were still detectable 1 year after trauma or stroke. It is likely that the subsequent expression of CD68 on MHC II-positive microglia reflects the conversion to a macrophage phenotype, when cells are phagocytosing degenerating presynaptic terminals in grey matter target regions at early survival times and removing axonal and myelin debris in descending tracts at later survival times. No T or B cell invasion or involvement of co-stimulatory B7 molecules (CD80 and CD86) was observed. It is possible that the up-regulation of MHC II on microglia that lack the expression of B7 molecules may be responsible for the prevention of a T cell response, thus protecting the spinal cord from secondary tissue damage. [less ▲]

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See detail14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.
Lemstra, A. W.; van Meegen, M. T.; Vreyling, J. P. et al

in Neurology (2000), 55(4), 514-6

OBJECTIVE: To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD). BACKGROUND: The 14-3-3 protein immunoassay on ... [more ▼]

OBJECTIVE: To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD). BACKGROUND: The 14-3-3 protein immunoassay on CSF has favorable test characteristics as a premortem diagnostic tool in CJD. However, the 14-3-3 protein is a normal cellular protein expressed in various tissues, and its presence in CSF reflects extensive destruction of brain tissue as in CJD, but also in ischemic stroke and meningoencephalitis. METHODS: 14-3-3 was tested in the CSF of a prospective series of 110 consecutive patients suspected of having CJD. RESULTS: The sensitivity was 97% and the specificity was 87% in this series. False-positive results were mainly caused by stroke and meningoencephalitis. CONCLUSION: The 14-3-3 protein is a highly sensitive and specific marker for CJD when used in the appropriate clinical context. [less ▲]

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See detailConception actuelle du traitement de l’arthrose
Reginster, Jean-Yves ULg; Henrotin, Yves ULg

in Revue de la Médecine Générale [=RMG] (2000), 177

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See detailClinical and neuropathological parameters affecting the diagnostic yield of nerve biopsy.
Deprez, Manuel ULg; de Groote, C. C.; Gollogly, L. et al

in Neuromuscular Disorders (2000), 10(2), 92-8

The value of nerve biopsy in the investigation of peripheral neuropathies is an important and controversial issue, partially obscured by the large variations in the diagnostic yield routinely reported for ... [more ▼]

The value of nerve biopsy in the investigation of peripheral neuropathies is an important and controversial issue, partially obscured by the large variations in the diagnostic yield routinely reported for this procedure. The aim of this study was to evaluate the clinical and neuropathological parameters affecting the yield of nerve biopsy. We compared the experience of two independent neuropathology laboratories with different patient recruitment and neuropathological methods over 11 years (01/1987-12/1997). Clinicopathological correlations were studied retrospectively in 355 patients. Using the same criteria of evaluation, contributive biopsies accounted for 35.5% in one laboratory, and 47.3% in the other. Clinical parameters affecting the yield of nerve biopsy were: (a) the presumptive diagnosis at time of referral for biopsy; (b) the distribution of symptoms; and (c) the interval between disease onset and biopsy. Greater yield was associated with clinically suspected vasculitis, inflammatory demyelinating neuropathy or hereditary sensorimotor neuropathies. Contributive findings were more often reported with multifocal or asymmetrical presentations, and onset-to-biopsy interval of less than 6 months. The contribution of nerve biopsy varied according to neuropathological techniques: (a) serial sections on frozen. paraffin-embedded and resin-embedded material improved sensitivity for interstitial pathology: (b) combined muscle biopsy increased sensitivity in the detection of vasculitis; and (c) teasing of nerve fibers added critical information to other classical techniques in only 4/102 cases. [less ▲]

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See detailManagement of central isosexual precocity: diagnosis, treatment, outcome.
LEBRETHON, Marie-Christine ULg; Bourguignon, Jean-Pierre ULg

in Current opinion in pediatrics (2000), 12(4), 394-9

The diagnosis of central isosexual precocity, a condition much more common in girls than in boys, is currently viewed as a spectrum of disorders between isolated premature thelarche and borderline early ... [more ▼]

The diagnosis of central isosexual precocity, a condition much more common in girls than in boys, is currently viewed as a spectrum of disorders between isolated premature thelarche and borderline early puberty. In some countries, a trend may be seen toward onset of puberty at earlier ages. Integration of the clinical findings with bone age, pelvic echography, and hormonal data as well as follow-up ascertainment of progression of development is critical to define which patients should be proposed for therapy. The use of long-acting forms of gonadotropin-releasing hormone (GnRH) agonists may not be indicated in slowly progressive variants or borderline early puberty because they do not affect final height. Preservation of height potential is particularly obvious in precocious puberty starting at young ages. In some selected patients, associated growth hormone therapy may increase adult height but further studies are warranted. The psychosocial and behavioral correlates of precocious puberty are an important and under investigated area. [less ▲]

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See detailPersistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Haematologica (2000), 85(6), 613-8

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve ... [more ▼]

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve clinical outcome. Therefore, we studied the value of (18)F-FDG PET for early evaluation of response in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We studied 28 patients by (18)F-FDG PET after a median of 3 cycles of polychemotherapy. The presence or absence of abnormal (18)F-FDG uptake was correlated to clinical outcome (median follow-up: 17.5 months, range 4-47 months). RESULTS: Five of 28 patients still had increased (18)F-FDG uptake in one or more sites previously shown to be involved by lymphoma at baseline evaluation. Only one of these five patients entered complete remission (CR), whereas among the 23 patients with negative (18)F-FDG PET studies, two died of toxicity during chemotherapy and all the others entered clinical CR (p<0.00001). All five patients with and 7/21 patients without residual abnormal (18)F-FDG uptake relapsed or reprogressed (positive predictive value for relapse: 100%, negative predictive value: 67%). By Kaplan-Meier analysis, progression-free survival (PFS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive patients and 81+/-9% and 62+/-12% for (18)F-FDG PET negative patients (p=0.0001). Overall survival (OS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive and 87+/-7% and 68+/-11% for (18)F-FDG PET negative patients (p<0.0001). INTERPRETATION AND CONCLUSIONS: Persistent tumoral (18)F-FDG uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL. Further studies are warranted to determine whether (18)F-FDG PET has a predictive value independent from conventional prognostic factors. However, the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient. Earlier evaluation after only one cycle of chemotherapy and quantitative analysis might increase the sensitivity of 18F-FDG PET is predicting treatment failure. [less ▲]

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See detailExperimental gerontology in Belgium: from model organisms to age-related pathologies
Toussaint, Olivier; Baret, P. V.; Brion, J.-P. et al

in Experimental Gerontology (2000), 35(8), 901-916

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See detailPotato tubers exhibit both homolytic and heterolytic hydroperoxide fatty acid-cleaving activities
Fauconnier, Marie-Laure ULg; Delcarte, J.; Hoyaux, P. et al

in Biochemical Society Transactions (2000), 28(6), 853-855

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See detailProjectively Equivariant Symbol Calculus for Bidifferential Operators
Boniver, Fabien ULg

in Letters in Mathematical Physics (2000), 54(2), 83-100

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See detailGenetics of Crohn's Disease Behaviour
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (2000), 63(4, Oct-Dec), 377-9

Crohn's disease is probably an heterogeneous entity. This heterogeneity may be linked to either genetics or environment. In particular the behaviour of the disease, i.e. the tendency to develop ... [more ▼]

Crohn's disease is probably an heterogeneous entity. This heterogeneity may be linked to either genetics or environment. In particular the behaviour of the disease, i.e. the tendency to develop stricturing and/or penetrating lesions, may be linked to the genetic background. While epidemiological and clinical data suggest the relevance of these behavioural classifications, the progresses in the characterization of the immuno-inflammatory reaction in the bowel wall shed a new light on possible candidate genes for these genetic predispositions to various Crohn's disease behaviours. Association studies an linkage analysis focusing on growth factors, metalloproteinases and their tissue inhibitors as well as cytokines may bring new interesting data in this field. [less ▲]

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See detailTheoretical Lifetimes and Oscillator Strengths in Ce II. Application to the Chemical Composition of the Sun
Palmeri, P.; Quinet, Pascal ULg; Wyart, J. F. et al

in Physica Scripta (2000), 61

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See detailSibling cannibalism in dorada under experimental conditions. I. Ontogeny, dynamics, bioenergetics of cannibalism and prey size selectivity
Baras, E.; Ndao, E.; Maxi, M. et al

in Journal of Fish Biology (2000), 57

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See detailEnantioseparation of aminoglutethimide with cyclodextrins in capillary electrophoresis and studies of selector-selectand interactions using NMR spectroscopy and electrospray ionization mass spectrometry.
Chankvetadze, Bezhan; Fillet, Marianne ULg; Burjanadze, N. et al

in Enantiomer (2000), 5(3-4), 313-22

The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs. The ... [more ▼]

The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs. The migration order of the enantiomers was opposite using beta-CD compared to alpha- and gamma-CDs as chiral selectors. In order to examine some underlying mechanisms of the chiral recognition the interaction of AGT with the chiral selectors was studied with one- and two-dimensional NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). The Job's and Scott's plots constructed based on the complexation-induced chemical shifts (CICS) observed in NMR spectra provided some preliminary information on the stoichiometry of the intermolecular complexes but did not seem to be absolutely reliable perhaps because the self-association of the analyte molecules and the formation of multiple type selectand-selector complexes. Therefore, an attempt was made to characterize the complexes using ESI-MS. This technique provided information on the stoichiometry and relative affinity constants of selector-selectand complexes. The information on the structure of complexes in the solution was obtained using one-dimensional rotating frame nuclear Overhauser enhancement (1D-ROESY) NMR spectroscopic studies. Significant differences were observed between the structures of the AGT complexes with beta- and gamma-CD. [less ▲]

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See detailSimilar Efficiency of DNA-Liposome Complexes and Retrovirus-Producing Cells for Hsv-Tk Suicide Gene Therapy of Peritoneal Carcinomatosis
Princen, Frederic; Lechanteur, Chantal ULg; Lopez, Marie-Josée ULg et al

in Journal of Drug Targeting (2000), 8(2), 79-89

Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 ... [more ▼]

Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment of peritoneal carcinomatosis induced in syngeneic rats by DHD/K12 colorectal adenocarcinoma cells. After in vitro determination of the best transduction conditions, rats were treated with multiple intraperitoneal injections of plasmid DNA containing one or two copies of CMV-driven HSV-tk gene (pCMV-TK and p(CMV-TK)2, respectively) associated with LipofectAMINE, each injection being followed by a Ganciclovir (GCV) course. Animals treated by DNA/liposome complexes and GCV or with retrovirus-producing cells and GCV showed a similar increase of survival as compared to the control group. After DNA/ liposome injections, expression of the tk transgene was detected in tumor nodes (epiploon) and also in liver, lung, spleen, bowels and brain. The expression was not homogeneous throughout the different organs and most likely reflected the transfection of only a limited number of cells. [less ▲]

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