References of "Article"
     in
Bookmark and Share    
Peer Reviewed
See detailExploration biologique actuelle du métabolisme du fer
Charlier, Corinne ULg; Plomteux, Guy ULg

in Revue de la Médecine Générale (1995), 123

Detailed reference viewed: 26 (0 ULg)
Peer Reviewed
See detailGrowth hormone response to clonidine in nondepressed patients with a history of suicide attempts.
Pitchot, William ULg; Hansenne, Michel ULg; Moreno, A. G. et al

in Biological Psychiatry (1995), 38(3), 201-3

Detailed reference viewed: 15 (4 ULg)
Peer Reviewed
See detailneuroendocrinology in the perinatal period
Battisti, Oreste ULg

in mini acta of belgian society of pediatrics (1995), 27

Detailed reference viewed: 12 (4 ULg)
Peer Reviewed
See detailLiège aussi doit rêver. A propos d'un monument et d'une fontaine sur la place Saint-Lambert
George, Philippe ULg

in chronique de la société royale Le Vieux-Liège (1995)

Detailed reference viewed: 3 (0 ULg)
See detailEvaluacion del comportamiento agressivo en ninos preescolares
Born, Michel ULg; Egido, A.; Pire, B.

in Revista Galega de Psicopedagogia (1995), 12(8), 149-165

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailEscape into Innocence: Ian McEwan and the Nightmare of History
Delrez, Marc ULg

in Ariel : A Review of International English Literature (1995), 26(2), 7-23

Detailed reference viewed: 109 (13 ULg)
Full Text
Peer Reviewed
See detailCytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime.
Mathy, Marianne ULg; Deby, Ginette ULg; Deby, C. et al

in Mediators of Inflammation (1995), 4(6), 437-43

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system ... [more ▼]

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system, myeloperoxidase catalyses the conversion of H(2)O(2) and CI(-) to the cytotoxic agent HOCl. Stimulated neutrophils can release MPO into the extracellular environment and then may cause tissue injury through direct endothelial cells lysis. We showed that human umbilical vein endothelial cells (HUVEC) were capable of taking up active MPO. In presence of H(2)O(2) (10(-4) M), this uptake was accompanied by cell lysis. The cytolysis was estimated by the release of (51)Cr from HUVEC and expressed as an index of cytotoxicity (IC). Dose dependent protection was obtained for CAZ concentrations ranging from 10(-5) to 10(-3) M;this can be attributed to inactivation of HOCl by the drug. This protection is comparable to that obtained with methionine and histidine, both of which are known to neutralize HOCl. This protection by CAZ could also be attributed to inactivation of H(2)O(2), but when cytolysis was achieved with H(2)O(2) or O(2) (-) generating enzymatic systems, no protection by CAZ was observed. Moreover, the peroxidation activity of MPO (action on H(2)O(2)) was not affected by CAZ, while CAZ prevented the chlorination activity of MPO (chlorination of monochlorodimedon). So, we concluded that CAZ acts via HOCl inactivation. These antioxidant properties of CAZ may be clinically useful in pathological situations where excessive activation of neutrophils occurs, such as in sepsis. [less ▲]

Detailed reference viewed: 38 (4 ULg)
Peer Reviewed
See detailEntre sémantique et syntaxe. Pour une classification des lexèmes verbaux en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

Detailed reference viewed: 25 (2 ULg)
Peer Reviewed
See detailSerum erythropoietin during autologous bone marrow transplantation: relationship to measures of erythroid activity.
Davies, S. V.; Fegan, C. D.; Kendall, R. et al

in Clinical & Laboratory Haematology (1995), 17(2), 139-44

Marked elevation of serum erythropoietin (sEPO) occurs following high dose chemotherapy for malignant disease. It has been proposed that the subsequent fall in sEPO constitutes a relative erythropoietin ... [more ▼]

Marked elevation of serum erythropoietin (sEPO) occurs following high dose chemotherapy for malignant disease. It has been proposed that the subsequent fall in sEPO constitutes a relative erythropoietin (EPO) deficiency, prompting trials of recombinant EPO to reduce red cell transfusion during chemotherapy. We have investigated these phenomena by serial estimations of reticulocytes and sEPO in 11 autologous marrow transplant recipients. sEPO reached two to five times baseline 0 to 5 days after transplant but the inverse relationship between sEPO and haematocrit was maintained. Observed to expected log sEPO (Epo ratio) rose and fell in parallel with sEPO, remaining greater than 1.0 throughout. A progressive fall in reticulocyte count during chemotherapy was followed by an increase during engraftment. The strong inverse relationships between reticulocytes and Epo ratio in the 10 days after initiating chemotherapy support the hypothesis that loss of EPO-receptor bearing erythroid precursors allows a rise in sEPO during chemotherapy. The elevation of Epo ratio levels during engraftment indicates that it is the availability of EPO-sensitive progenitors, rather than the supply of EPO, that limits the rate of resumption of erythropoiesis after high-dose chemotherapy. [less ▲]

Detailed reference viewed: 11 (2 ULg)
Full Text
Peer Reviewed
See detailQuelques alternatives à la régression classique dans le cas de la colinéarité
Palm, Rodolphe ULg; Iemma, A. F.

in Revue de Statistique Appliquée (1995), XLIII(2), 5-33

In this note, we briefly describe some biased regresion methods : principal component regression, latent root regression analysis, partial least square regression, ridge regression and use of James-Stein ... [more ▼]

In this note, we briefly describe some biased regresion methods : principal component regression, latent root regression analysis, partial least square regression, ridge regression and use of James-Stein's estimators. All these methods are illustrated by an example. [less ▲]

Detailed reference viewed: 29 (1 ULg)
Peer Reviewed
See detailVariable location of the enterotoxin gene (cpe) in Clostridium perfringens.
Cornillot, Emmanuel; Saint-Joanis, Brigitte; Daube, Georges ULg et al

in Molecular Microbiology (1995), 15

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailComment explorer la sensibilite a l'insuline chez l'homme?
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in Annales d'Endocrinologie (1995), 56(5), 523-30

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose ... [more ▼]

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose clamp is the reference method, well validated and easy to interpret, which allows various extensions to the basic experimental procedure in order to obtain more valuable information on the specific effects of insulin on the various aspects of glucose metabolism. However, it is time-consuming and labour-intensive. In contrast, the intravenous glucose tolerance test is easier to perform, but its interpretation is much more difficult and requires a modeling approach called the "minimal model". If the intravenous glucose tolerance test probably represents a good screening test, mainly on a population basis, the glucose clamp still remains the gold standard method to study insulin sensitivity in man. [less ▲]

Detailed reference viewed: 62 (0 ULg)
Peer Reviewed
See detailBioremediation of diesel-polluted soils.
Jacques, Ph; Bossrez, S.; Mergeay, M. et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103(B46),

Detailed reference viewed: 3 (2 ULg)
Peer Reviewed
See detailEffect of prolonged exercise on neutrophil myeloperoxidase secretion
Bury, Thierry ULg; PIRNAY, Freddy ULg

in International Journal of Sports Medicine (1995)

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailLack of LTR and ENV genetic variation during bovine leukemia virus-induced leukemogenesis.
Willems, Luc ULg; Kerkhofs, P.; Burny, A. et al

in Virology (1995), 206(1),

Detailed reference viewed: 12 (5 ULg)
Peer Reviewed
See detailReprésentations de la justice sociale - L'exemple de la Belgique francophone
Jacquemain, Marc ULg

in Année Sociologique (L') (1995), 45

Lorsqu'on analyse les réponses à une batterie de questions sur la justice sociale en Belgique, on voit apparaître trois facteurs, qui ne correspondent pas à des "valeurs" mais plutôt à des "thématiques ... [more ▼]

Lorsqu'on analyse les réponses à une batterie de questions sur la justice sociale en Belgique, on voit apparaître trois facteurs, qui ne correspondent pas à des "valeurs" mais plutôt à des "thématiques transversales". Le premier facteur concerne l'inclusion : la justice est-elle due, par exemple aux immigrés ou aux chômeurs ? Le deuxième facteur concerne le rôle géénral de l'Etat social. Le troisième facteur concerne la dimension première ou subsidiaire de la sécurité sociale. [less ▲]

Detailed reference viewed: 43 (7 ULg)
Full Text
Peer Reviewed
See detailMolecular description of the interactions of aminoglycoside antibiotics with negatively-charged phospholipids. Theoretical molecular modelling and experimental results.
Mingeot-Leclercq, M. P.; Schanck, A.; Van Bambeke, F. et al

in Pharmacology (1995), 14

Detailed reference viewed: 13 (0 ULg)
Peer Reviewed
See detailThe role of the insurance industry in piloting private sector security and prevention policy
Lemaître, André ULg

in European Journal on Criminal Policy and Research (1995), 3.1

Detailed reference viewed: 21 (5 ULg)
Full Text
Peer Reviewed
See detailThe importance of liposomes as models and tools in the understanding of photosensitization mechanisms
Hoebeke, Maryse ULg

in Journal of Photochemistry and Photobiology B : Biology (1995), 28(3), 189-196

The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in ... [more ▼]

The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in phototherapy. Liposomes are simple vesicles in which an aqueous phase is enclosed by a phospholipidic membrane. They are suitable models mimicking specific situations occurring <br />m vivo and they allow study of the influence of physieochemieal, photobioiogieal and biochemical factors on the uptake of photosensitizers by tissues, their mechanisms of action and the subsequent photoinduced tumor necrosis. Moreover, solubilization of the sensitizer into the bilayer seems to improve its tumoral selectivity and its photodynamic efficiency. [less ▲]

Detailed reference viewed: 17 (8 ULg)
Full Text
Peer Reviewed
See detailSecondary structure of monoamine oxidase by FTIR spectroscopy.
Wouters, J.; Ramsay, R.; Goormaghtigh, E. et al

in Biochemical and Biophysical Research Communications (1995), 208(2), 773-8

The secondary structure of human monoamine oxidase A and bovine monoamine oxidase B has been investigated by Fourier Transform Attenuated Total Reflection Spectroscopy (FTIR ATR). The experimental results ... [more ▼]

The secondary structure of human monoamine oxidase A and bovine monoamine oxidase B has been investigated by Fourier Transform Attenuated Total Reflection Spectroscopy (FTIR ATR). The experimental results are compared for both isoenzymes and the data are incorporated in a statistical attribution of secondary structure of the enzyme describing the distinct folding and molecular specificity of the two types of monoamine oxidase. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailConformational Analysis Of Non-Sulfonylurea Hypoglycemic Agents Of The Meglitinide Family
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Biochemical Pharmacology (1995), 50(11), 1879-84

Detailed reference viewed: 14 (2 ULg)
Peer Reviewed
See detailPersonal name anomia: A single case study
Fery, P.; Vincent, Eric ULg; Brédart, Serge ULg

in Cortex (1995), 31

Detailed reference viewed: 36 (6 ULg)
Full Text
Peer Reviewed
See detailRelative importance of the trophic and direct pathways on PCB contamination in the rotifer species Brachionus calyciflorus (Pallas)
Joaquim-Justo, Célia ULg; Gosselain, V; Descy, Jean-Pierre et al

in Hydrobiologia (1995)

To determine the contribution of food ingestion (trophic pathway) to PCB contamination of zooplankton in the river Meuse (Belgium), we used 14 C-labelled algae (Dictyosphaerium ehrenbergianum) to measure ... [more ▼]

To determine the contribution of food ingestion (trophic pathway) to PCB contamination of zooplankton in the river Meuse (Belgium), we used 14 C-labelled algae (Dictyosphaerium ehrenbergianum) to measure ingestion and assimilation rates in the rotifer species Brachionus calyciflorus . When the concentration of algae in the culture medium varied from 20 103 to 200 103 algal cells ml -1 (0.12 to 1 .18 mg C 1 - '), the Brachionus calyciflorus ingestion rate varied from 0 .25 ± 0 .12 to 1 .52 ± 0 .43 ng C ind -1 h-1 at 15 °C and from 0 .74 ± 0 .17 to 5 .93 ± 0.61 ng Cind-' h-1 at 20 °C . The assimilation efficiency (ratio of the assimilation rate to the ingestion rate) measured in a culture medium containing 200 103 algal cells ml`' was 55 .7 ± 5.8%. Since the PCB concentration measured in the phytoplankton of the river Meuse is about 3 pg PCBs g -1 D.W., the estimated PCB contamination of zooplankton ascribable to the trophic pathway ranges from 0 .22 ± 0 .17 to 1 .31 ± 0.77 jag PCBs g -1 D.W. at 15 °C and from 0.64 ± 0 .34 to 5 .10 ± 2 .10 pg PCBs g -1 D. W. at 20'C . The lower figure based on measurements effected at 20 ° C is comparable to the actual level measured in zooplankton samples collected in the river Meuse (0 .69 ± 0.20 pg PCBs g`' D.W.) . The applicability of the formula used in our estimate was checked in a 48-hour in vitro experiment in which the rotifers were fed contaminated algae . The PCB accumulation measured in the rotifers was found to coincide with the calculated PCB contamination . Additional experiments were carried out to determine the contribution of the direct pathway to PCB contamination of zooplankton living in the river Meuse (0.02 pg PCBs 1-1 of water; average dissolved organic matter : 3 mg C 1 -1 ). The PCB concentration in zooplankton resulting from direct uptake of PCBs from the water was estimated at 0 .19 ± 0.05 jug PCBs g -1 D.W. These results show that in zooplankton living in polluted ecosystems, PCBs are likely to accumulate via the trophic pathway to concentrations up to 30 times higher than by direct contamination . Furthermore, our estimates of PCB contamination via the trophic pathway coincide quite well with actual concentrations measured in situ . [less ▲]

Detailed reference viewed: 13 (3 ULg)
Peer Reviewed
See detailComparison of six serum ferritin immunoassays and isoferritin spectrotypes in malignancies
Vernet, M.; Renversez, J. C.; Lasne, Y. et al

in Annales de Biologie Clinique (1995), 53

Detailed reference viewed: 15 (0 ULg)
Full Text
See detailAutovidéoscopie et formation des enseignants: les techniques d'analyse de gestes
Cloes, Marc ULg; Piéron, Maurice

in Eduquer et former. Théories et pratiques (1995), 3/4

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation ... [more ▼]

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation des techniques d'analyse de gestes sur vidéo et d'enseignement simulé. L'articulation de l'analyse avec la littérature scientifique du domaine laisse une grande liberté de transposition vers d'autres champs d'application. [less ▲]

Detailed reference viewed: 36 (4 ULg)
Peer Reviewed
See detailLa grammaire au secours de la datation des textes
Winand, Jean ULg

in Revue d'Egyptologie (1995), 46

Detailed reference viewed: 41 (4 ULg)
See detailLocalization and transmembrane topology of a new member of the mitochondrial carrier family, the yeast RIM 2 gene product
Elmoualij, Benaïssa ULg; Duyckaerts, Claire ULg; Lamotte-Brasseur, J. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995)

Detailed reference viewed: 23 (9 ULg)
Full Text
Peer Reviewed
See detailExpertise scientifique et action publique : le cas du changement climatique dans trois pays européens
Mormont, Marc ULg; Dasnoy, Christine ULg

in Natures Sciences Sociétés (1995), 3(&), 16-25

L'expertise scientifique du changement climatique fait l'objet d'une réception très différente en France, en Allemagne et en Belgique. cet état de fait semble lié à la fois à des configurations politiques ... [more ▼]

L'expertise scientifique du changement climatique fait l'objet d'une réception très différente en France, en Allemagne et en Belgique. cet état de fait semble lié à la fois à des configurations politiques différentes, à des procédures spécifiques mais aussi aux stratégies des scientifiques lesquelles dépendent de leur anticipation de cette réception. Cette stratégie des "sources" d'information ne laisse pas de poser des questions sur l'expertise. [less ▲]

Detailed reference viewed: 99 (6 ULg)
Full Text
Peer Reviewed
See detailApplication of the Wavelet Transform for GPS Cycle Slip Correction and Comparison with Kalman Filter
Collin, Fabienne; Warnant, René ULg

in Manuscripta Geodaetica (1995), 20

Detailed reference viewed: 277 (10 ULg)
Peer Reviewed
See detailSatellite image maps of Warsaw in the scale 1 :25,000
Kaczynski, Rom; Donnay, Jean-Paul ULg; Muller, Fabrice

in EARSeL Advances in Remote Sensing (1995), 4(2), 100-103

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailProximal Migration of Vena Caval Filters: Report of Two Cases with Operative Retrieval
DEFRAIGNE, Jean ULg; Vahdat, Olivier; Lacroix, Hendrik et al

in Annals of Vascular Surgery (1995), 9(6), 571-5

Operative retrieval of two proximally migrated vena caval filters was performed in two patients, ages 42 and 45 years, respectively. In the first patient the filter was encrusted in the right ventricle ... [more ▼]

Operative retrieval of two proximally migrated vena caval filters was performed in two patients, ages 42 and 45 years, respectively. In the first patient the filter was encrusted in the right ventricle, and in the second one the filter was found in the pulmonary artery. Both filters were retrieved under cardiopulmonary bypass via an incision in the right atrium and the pulmonary artery, respectively. These two observations underscore the risk of increased unwarranted indications and consequent higher complication rates of vena caval filters. [less ▲]

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailPrésence d'appendices mucoïdes sur les ascospores de Raciborskiella janeirensis (Müll. Arg.) R. Sant.
Roux, Claude; Sérusiaux, Emmanuël ULg

in Bulletin de la Société Linnéenne de Provence (1995), 46

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailHYDRODYNAMIC SIMULATIONS OF GALAXY FORMATION .1. DISSIPATION AND THE MAXIMUM MASS OF GALAXIES
Thoul, Anne ULg; WEINBERG, D. H.

in Astrophysical Journal (1995), 442(2), 480-491

We describe an accurate, one-dimensional, spherically symmetric Lagrangian hydrodynamics/gravity code, designed to study the effects of radiative cooling and photoionization on the formation of ... [more ▼]

We describe an accurate, one-dimensional, spherically symmetric Lagrangian hydrodynamics/gravity code, designed to study the effects of radiative cooling and photoionization on the formation of protogalaxies. The code can treat an arbitrary number of fluid shells (representing baryons) and collisionless shells (representing cold dark matter). As a test of the code, we reproduce analytic solutions for the pulsation behavior of a poly-trope and for the self-similar collapse of a spherically symmetric, cosmological perturbation. In this paper we concentrate on the effects of radiative cooling, examining the ability of collapsing perturbations to cool within the age of the universe. In contrast to some studies based on order-of-magnitude estimates, we find that cooling arguments alone cannot explain the sharp upper cutoff observed in the galaxy luminosity function. [less ▲]

Detailed reference viewed: 14 (3 ULg)
Peer Reviewed
See detailPriming production of people's names
Valentine, T.; Moore, V.; Brédart, Serge ULg

in Quarterly Journal of Experimental Psychology (1995), 48A

Detailed reference viewed: 23 (3 ULg)
Peer Reviewed
See detailTHEORY OF THE THERMAL-CONDUCTIVITY OF RE AL-2 COMPOUNDS
Rassili, Ahmed ULg; Ausloos, Marcel ULg

in Journal of Magnetism & Magnetic Materials (1995), 147(3), 341-345

On the basis of the variational method for transport coefficients we have calculated the thermal conductivity of RE Al-2-like systems as a function of temperature. The low-temperature limit obeys ... [more ▼]

On the basis of the variational method for transport coefficients we have calculated the thermal conductivity of RE Al-2-like systems as a function of temperature. The low-temperature limit obeys Matthiessen's rule 1/kappa = 1/kappa(ph) + 1/kappa(s) + 1/kappa(imp) where the three components are the contributions arising from e(-)-phonon, e(-)-localized spin and e(-)-impurity interactions, respectively. The temperature dependence of each term has been calculated, as well as the superposition of all three. The influence of the physical parameters (spin value, Debye temperature, cut-off wave vector, Fermi energy, etc.) is shown. The theory is in good agreement with reported data for GdAl2. [less ▲]

Detailed reference viewed: 20 (6 ULg)
Full Text
Peer Reviewed
See detailAbility of Bronchodilators to Prevent Bovine Experimental Respiratory Distress
Genicot, Bruno; Lambert, Philippe ULg; Votion, Dominique ULg et al

in Veterinary Research (1995), 26(4), 276-283

This cross-over trial involving 6 Blue Belgian double-muscled calves aimed to investigate whether ipratropium bromide inhaled alone or in combination with clenbuterol hydrochloride could prevent the ... [more ▼]

This cross-over trial involving 6 Blue Belgian double-muscled calves aimed to investigate whether ipratropium bromide inhaled alone or in combination with clenbuterol hydrochloride could prevent the dramatic clinical and pulmonary disturbances that are observed during an experimentally induced bronchoconstriction. Inhaled bronchodilators significantly influenced the clinical and functional responses of bovines subjected to a 5-hydroxytryptamine perfusion. However, despite a mean (standard error) wash-out period of 11.2 (3.1) and 7.5 (0.9) d after the 1st and the 2nd one-day challenges, respectively, first-order carry-over effects (ie those remaining from the previous treatment), effects of the period during which the treatment was allocated and interaction effects did not allow a definitive interpretation of overall treatment differences. [less ▲]

Detailed reference viewed: 42 (12 ULg)
Full Text
Peer Reviewed
See detailLichens and lichenicolous fungi on Laing Island (Papua New Guinea)
Aptroot, André; Diederich, Paul; Sérusiaux, Emmanuël ULg et al

in Bibliotheca Lichenologica (1995), 57

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detail- Establishment of normal and transformed root cultures of Artemisia annua L. for artemisinin production.
Jaziri, M.; Shimomura, K.; Yoshimatsu, K. et al

in Journal of Plant Physiology (1995), 145(1-2), 175-177

Transformed cultures of Artemisia annua L. (Asteraceae) were established by the co-culture method using leaf segments of A. annua and Agrobacterium rhizogenes NCIB 8196 or MAFF 03-01724. The hairy root ... [more ▼]

Transformed cultures of Artemisia annua L. (Asteraceae) were established by the co-culture method using leaf segments of A. annua and Agrobacterium rhizogenes NCIB 8196 or MAFF 03-01724. The hairy root clones thus obtained grew vigorously on hormone-free medium, showing the typical transformed morphology. The genetic transformation of the root was proved by the opine assay. Normal root and shoot cultures were also established. A highly specific and sensitive enzyme-linked immuno-sorbent assay (ELISA) method was used for the detection and semi-quantitative determination of artemisinin and structurally related compounds in these cultures. The presence of artemisinin was confirmed by gas chromatography coupled to mass spectrometry (GC-MS) analysis. The hairy roots cultured in the dark produced no detectable level of artemisinin as shown by the adventitious shoots cultured under light conditions. The ELISA analysis of the green hairy roots cultured in liquid medium under a 16 h light/day photoperiod showed the existence of compound(s) structurally related to artemisinin, though normal and hairy roots cultured in the dark give no detectable levels of immuno-signal. [less ▲]

Detailed reference viewed: 63 (8 ULg)
Full Text
Peer Reviewed
See detailEtude épidémiologique de la toxoplasmose chez les femmes enceintes à Amiens (Picardie): nécessité d'une enquête nationale
Carme, Bernard; Lenne, Evelyne; Tirard, Véronique et al

in Journal de Pédiatrie et de Puériculture (1995), 8(1), 761-763

Il s'agit d'une enquête réalisée à Amiens du 1er mars 1993 au 28 février 1994 chez les femmes venant d'accoucher pour évaluer leur niveau d'immunité vis à vis de la toxoplasmose et leur connaissances des ... [more ▼]

Il s'agit d'une enquête réalisée à Amiens du 1er mars 1993 au 28 février 1994 chez les femmes venant d'accoucher pour évaluer leur niveau d'immunité vis à vis de la toxoplasmose et leur connaissances des mesures préventives. L'analyse des données s'est faite grâce au locigiel Epidemio sur un total de 987 femmes. La séroprévalence est de 58% et l'analyse montre que c'est la consommation de viande peu ou pas cuite et la présence d'un chat dans l'entourage qui sont les 2 facteurs de risque majeurs. La quasi totalité des femmes a pu citer au moins 2 moyens de prévention efficaces et les reccommandations sont largement suivies. En conclusion, les résultats sont rassurants. Cependant, une enquête nationale serait nécessaire pour permettre une évaluation sur le plan national. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Peer Reviewed
See detailAn approach to corrective control of voltage instability using simulation and sensitivity
Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (1995), 10

Detailed reference viewed: 23 (1 ULg)
Peer Reviewed
See detailLes cellules dendritiques folliculaires: phenotype, origine et fonctions.
Heinen, Ernst ULg

in Pathologie Biologie (1995), 43(10), 848-57

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic ... [more ▼]

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic cells presenting antigens to T cells. They are long-lived and derived from local mesenchymal cells. Their complex cytoplasmic extensions, covered with dendrites, are intermingled in a network which surrounds germinal B and T cells. On their surface, receptors fix immune complexes without endocytosis and adhesion molecules ensure close contacts to the lymphoid cells. FDC influence the migration, activation, proliferation, survival and differentiation of B cells into memory cells and probably act also on the germinal center T cells. [less ▲]

Detailed reference viewed: 81 (5 ULg)
Full Text
Peer Reviewed
See detailFast Routine Production of L-[11C-methyl]methionine with Al2O3KF
Schmitz, Frédéric; Plenevaux, Alain ULg; Del-Fiore, Guy et al

in Applied Radiation & Isotopes (1995), 46(9), 893-897

No-carrier-added (nca) L-[11C-methyl]methionine was prepared via the very fast S-alkylation of L-homocysteine adsorbed on AI203/KF with [11C]iodomethane at room temperature in ethanol. The alkylation was ... [more ▼]

No-carrier-added (nca) L-[11C-methyl]methionine was prepared via the very fast S-alkylation of L-homocysteine adsorbed on AI203/KF with [11C]iodomethane at room temperature in ethanol. The alkylation was realized with a radiochemical yield of 94 +/- 4% EOB (n = 20). More than 90% (n = 20) of the precursor L-homocysteine remained adsorbed on the solid support and was eliminated by a simple filtration. After reaction, neither racemization nor by-product were detected. The purification process was thus limited to a C18 Sep-Pak followed by an alumina Sep-Pak. The radiochemical purity measured on the final solution was shown to be > 99%. The only chemical contaminant was L-homocysteine (+ 10 µg). With this new technique, L-[11C-methyl]methionine was ready for injection within 10 min from [11C]CO2 with a specific activity ranging around 37 + 5.6 GBq (1 +/- 0.15 Ci)//tmol EOB. Through this procedure L-[11C-methyl]methionine can be prepared without preparative HPLC purification, This is an important simplification for the fast routine production of one of the most widely used radiopharmaceutical compounds for PET. [less ▲]

Detailed reference viewed: 97 (2 ULg)
Peer Reviewed
See detailActivation of leucocytes after prolonged physical exercise
Bury, Thierry ULg; PIRNAY, Freddy ULg

in Mediators of Inflammation (1995), 4

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailPropagations en réseaux de cours d'eau d'ondes de crues incluant des ressauts
Pirotton, Michel ULg

in Tribune de l'Eau (La) (1995), 49(574), 23-33

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailSOURCE STRATEGIES AND THE MEDIATIZATION OF CLIMATE-CHANGE
Mormont, Marc ULg; Dasnoy, Christine ULg

in Media, Culture & Society (1995), 17(1), 49-64

A wide approach to the problem of science-media relations is taken in this study of the visibility of science in three >European countries. Differences of national cultures within France, Germany and ... [more ▼]

A wide approach to the problem of science-media relations is taken in this study of the visibility of science in three >European countries. Differences of national cultures within France, Germany and Belgium hod the key to the analysis. This paper explores the impact on the media's representation of climate change that derives from the variations in the balance of power between the press, its scientific sources and other actors, especially pressure groups whoa have interest in how science is represented. France and Germany are shown to have very different approaches scignificantly in distinctive models of the role of media held by scinetists. These models look to be based in what is termed a "spontaneous media sociology" that frame the webs of relations between media and their sources and have a feedback effect oin them. [less ▲]

Detailed reference viewed: 272 (4 ULg)
Peer Reviewed
See detailEvaluation bryologique d'un projet de réinondation par les crues du Rhin: l'exemple de la réserve naturelle d'Erstein (Alsace, France)
Vanderpoorten, Alain ULg; Klein, J. P.; De Zuttere, P.

in Belgian Journal of Botany (1995), 128

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailInsulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.
Malaisse, W. J.; Nadi, A. B.; Malaisse-Lagae, F. et al

in General Pharmacology (1995), 26(6), 1319-25

1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial ... [more ▼]

1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailThe Kozani-Grevena (Greece) earthquake of May 13, 1995, Ms=6.6, Preliminary results of a field multidisciplinary survey
Hatzfeld, D.; Nord, J.; Paul, A. et al

in Seismological Research Letters (1995), 66

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailA comprehensive analysis of mid-term voltage stability
Van Cutsem, Thierry ULg; Jacquemart, Yannick; Marquet, Jean-Noël et al

in IEEE Transactions on Power Systems (1995), 10

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailCell surface binding of TIMP-2 and pro-MMP-2/TIMP-2 complex
Emmert-Buck, M. R.; Emonard, H. P.; Corcoran, M. L. et al

in FEBS Letters (1995), 364(1), 28-32

Tissue inhibitor of metalloproteinases (TIMP-2) is a low molecular weight proteinase inhibitor capable of inhibiting activated matrix metalloproteinases (MMPs). TIMP-2 is found both free and in a 1:1 ... [more ▼]

Tissue inhibitor of metalloproteinases (TIMP-2) is a low molecular weight proteinase inhibitor capable of inhibiting activated matrix metalloproteinases (MMPs). TIMP-2 is found both free and in a 1:1 stoichiometric complex with the pro-enzyme form of MMP-2 (pro-MMP-2/TIMP-2 complex). We have measured the binding of recombinant TIMP-2 to intact HT-1080 and MCF-7 cells. HT-1080 cells in suspension bound 125I-labeled rTIMP-2 with a Kd of 2.5 nM and 30,000 sites/cell. Monolayers of MCF-7 cells were similarly found to bind [125I]rTIMP-2 with a Kd of 1.6 nM and 25,000 sites/cell. Specific binding of MMP-2 alone to HT-1080 cells was not observed; however, pro-MMP-2/TIMP-2 complex was capable of binding to the surface of HT-1080 cells in a TIMP-2-dependent manner. Binding of rTIMP-2 was not competed by the presence of TIMP-1. These results suggest that rTIMP-2 alone binds directly to the cell surface of HT-1080 and MCF-7 cell lines, and TIMP-2 is capable of localizing MMP-2 to the surface of HT-1080 cells via interaction with a specific binding site. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailThe hydrophobic effect in protein folding.
Lins, Laurence ULg; Brasseur, Robert ULg

in FASEB Journal (1995), 9(7), 535-40

In this review of protein folding we consider the noncovalent interactions existing between atoms or molecules at the molecular level. The electrostatic, Van der Waals, hydrogen bonding, and hydrophobic ... [more ▼]

In this review of protein folding we consider the noncovalent interactions existing between atoms or molecules at the molecular level. The electrostatic, Van der Waals, hydrogen bonding, and hydrophobic interactions are described and their contribution to protein conformation is discussed. The growing interest in the hydrophobic effect arises from its importance in the protein folding process, and a semiempirical simulation of the free energy of solvation is proposed. In most proteins, the different forces we describe contribute to the stability of the protein conformation in a complex way. However, in the case of the apolipoproteins and cytochrome C551, the energetic contributions are easily distinguished. For this reason, these proteins are used to illustrate the importance of the different energy fields. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Peer Reviewed
See detailR&D, technological progress and efficiency change in industrial activities
Perelman, Sergio ULg

in Review of Income and Wealth (1995), (41), 349-366

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic ... [more ▼]

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic frontiers and non-parametric production frontiers (DEA). The TFP is decomposed into two components, technological progress and efficiency change, that can also be interpreted as the results of the innovation and catching-up process, respectively. Finally their relationship is tested with a set of potential explanatory variables that includes R&D expenditures, international competition, and structural characteristics. It appears that the distinction between technological and efficiency performances does matter and must be taken into account in the design of industrial policy. [less ▲]

Detailed reference viewed: 47 (1 ULg)
See detailTrente cinq années de programmes d'histoire dans l'enseignement secondaire francophone
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1995), 45e année(n°3), 1-6

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailEndogenous reproductive hormones and nocturnal rhythms in partner preference and sexual behavior of ATD-treated male rats.
Bakker, Julie ULg; van Ophemert, J.; Timmerman, M. A. et al

in Neuroendocrinology (1995), 62(4), 396-405

Male rats received subcutaneously silastic capsules, containing the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD), shortly after birth. Control males were given silastic capsules containing ... [more ▼]

Male rats received subcutaneously silastic capsules, containing the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD), shortly after birth. Control males were given silastic capsules containing cholesterol. The capsules were removed at the age of 21 days. In adulthood, blood serum was collected early and late in the dark phase of the light/dark cycle (experiment I). Testosterone and luteinizing hormone and follicle stimulating hormone (FSH) fluctuated nocturnally, both in ATD and control males, with highest levels late in the dark phase. FSH levels were significantly higher in ATD males. Nocturnal levels of inhibin, a selective suppressor of pituitary FSH secretion, also fluctuated in both ATD and control males, with lowest levels late in the dark phase. In experiment II, ATD and control males were tested for partner preference behavior in a three-compartment box (choice: sexually active male vs. estrous female) early and late in the dark phase. When gonadally intact, ATD males, but not controls, showed a clear nocturnal rhythmicity in partner preference behavior and sexual behavior. Early in the dark phase, such ATD males preferred the vicinity of and interaction with a sexually active male. Late in the dark phase, this preference for the active male shifted to a preference for the estrous female. Control males preferred the estrous female. After castration and subsequent treatment with testosterone via silastic capsules, which ensured constant blood serum levels, ATD males continued to show their nocturnal rhythms in partner preference behavior and in sexual behavior. Thus, the underlying mechanism of the nocturnal rhythmicity phenomenon is an organizational effect of neonatal ATD treatment rather than an activational effect of fluctuating serum hormone levels. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailRobert Feulgen Prize Lecture 1995. New approaches to in situ detection of nucleic acids.
Thiry, Marc ULg

in Histochemistry & Cell Biology (1995), 104(2), 81-95

The present paper reviews recent results obtained by different molecular biology-based, immunocytological approaches to the localization and identification of nucleic acids in sections of biological ... [more ▼]

The present paper reviews recent results obtained by different molecular biology-based, immunocytological approaches to the localization and identification of nucleic acids in sections of biological material. Examples of sensitive, high-resolution detection methods for RNA, DNA or specialized DNA regions are presented. Special emphasis is placed on the potential values and limitations of these new methods. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Peer Reviewed
See detailCompressive strength for service and accident conditions
Schneider, Ulrich; Schwesinger, P.; Debicki, Gérard et al

in Materials and Structures (1995), 28(181), 410-414

Detailed reference viewed: 26 (1 ULg)
Peer Reviewed
See detailLumière und der Augen-Blick
Belloi, Livio ULg

in KINtop : Jahrbuch zur Erforschung des frühen Films (1995), 4

Analyse de la pratique de la vue chez Lumière, envisagée dans sa double dimension spatiale et temporelle.

Detailed reference viewed: 20 (2 ULg)
See detailLa naissance des cités au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

Detailed reference viewed: 21 (2 ULg)
See detailNotice sur Marcel Migeotte
Biémont, Emile ULg

in Annuaire de l'Académie Royale de Belgique (1995)

Detailed reference viewed: 6 (2 ULg)
See detailLa géodésie spatiale à l'Observatoire Royal de Belgique
Warnant, René ULg; Bruyninx, Carine

in Nouvelles de la Science et des Technologies (1995), 13(2/3/4), 29-31

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailInhaled nitric oxide for hemodynamic support after postpneumectomy ARDS
Chiche, Jean-Daniel; Canivet, Jean-Luc ULg; Damas, Pierre ULg et al

in Intensive Care Medicine (1995), 21(8), 675-678

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailPain after laparoscopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine.
Joris, Jean ULg; Thiry, E.; Paris, P. et al

in Anesthesia and Analgesia (1995), 81(2), 379-84

Although pain after laparoscopic cholecystectomy is less intense than after open cholecystectomy, some patients still experience considerable discomfort. Furthermore, the characteristics of ... [more ▼]

Although pain after laparoscopic cholecystectomy is less intense than after open cholecystectomy, some patients still experience considerable discomfort. Furthermore, the characteristics of postlaparoscopy pain differ considerably from those seen after laparotomy. Therefore, we investigated the time course of different pain components after laparoscopic cholecystectomy and the effects of intraperitoneal bupivacaine on these different components. Forty ASA physical status grade I-II patients were randomly assigned to receive either 80 mL of bupivacaine 0.125% with epinephrine 1/200,000 (n = 20) or the same volume of saline (n = 20) instilled under the right hemidiaphragm at the end of surgery. Intensity of total pain, visceral pain, parietal pain, and shoulder pain was assessed 1, 2, 4, 6, 8, 24, and 48 h after surgery. Analgesic consumption was also recorded. Patient data were similar in the two groups. In the saline group, visceral pain was significantly more intense than parietal pain at each time point; visceral and parietal pain were greater than shoulder pain during the first 8 h postoperatively. Intraperitoneal bupivacaine did not significantly affect any of the different components of postoperative pain. Analgesic consumption was similar in the two groups. This study demonstrates that visceral pain accounts for most of the pain experienced after laparoscopic cholecystectomy. Intraperitoneal bupivacaine is not effective for treating any type of pain after laparoscopic cholecystectomy. [less ▲]

Detailed reference viewed: 57 (0 ULg)
Peer Reviewed
See detailIS THE PRESENCE OF MESOTROPHIC PLANT-COMMUNITIES IN THE PEAT-BOGS OF HAUTES-FAGNES (BELGIUM) CONNECTED WITH TONALITE INTRUSIONS IN THE REVINIAN LAYERS
Hambuckers, Alain ULg; Schumacker, René ULg; Remacle, Jean ULg et al

in Belgian Journal of Botany (1995), 128(1), 48-56

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species ... [more ▼]

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species. Based on the fact that there are several outcrops of tonalite in the region and particularly one in the Nature Reserve, a hypothesis to explain these singularities of the vegetation implies discontinuities of the bedrock provoked by intrusions of this magmatic rock in the Revinian layer covering the region. Seventeen plots containing Phragmites australis were examined and vegetation was described. Silt and soil water were sampled and analyzed for mineral contents in 15 sites. The differences of mineral composition between the P. australis plots and their surrounding environment confirmed the more mesotrophic characteristics of these plots (i.e. higher pH, higher Ca and Mg contents, lower Al content). However, the lower Zn, Pb and Fe contents would lead to reject the hypothesis of intrusions of tonalite since these elements are more abundant in the tonalite and its mineralization than in the Revinian rock. Nevertheless, the overall ecological conditions of the examined plots and the differences of plant species composition suggested that the observed chemical environment could be evoked for explaining the distribution of the mesotrophic species in the oligotrophic environment of the Nature Reserve. Consequently, an alternative hypothesis is proposed. [less ▲]

Detailed reference viewed: 30 (4 ULg)
Peer Reviewed
See detailA Simple Model for the Fire Resistance of Axially-Loaded Members According to Eurocode 3
Franssen, Jean-Marc ULg; Schleich, Jean-Baptiste; Cajot, Louis-Guy

in Journal of Constructional Steel Research (1995), 35

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental ... [more ▼]

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental test results. This model has been subsequently included in Eurocode 3. [less ▲]

Detailed reference viewed: 26 (1 ULg)
Peer Reviewed
See detailEffects of infused sodium lactate on glucose and energy metabolism in healthy humans.
Paquot, Nicolas ULg; Schneiter, P.; Cayeux, M. C. et al

in Diabètes & Métabolism (1995), 21(5), 345-52

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg ... [more ▼]

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg-1.min-1) euglycaemic clamp. Glucose rate of appearance (GRa) and disappearance (GRd) were measured from plasma dilution of infused U- 13C glucose, and glucose oxidation (G(ox)) from breath 13CO2 and plasma 13C glucose. In basal conditions, lactate infusion did not alter G(ox) (8.8 +/- 0.9 vs 9.2 +/- 1.1 mumol.kg-1.min-1), while GRa slightly decreased from 15.2 +/- 0.8 basal to 13.9 +/- 0.9 mumol.kg-1.min-1 after lactate (p < 0.05). During a hyperinsulinaemic clamp, hepatic glucose production was completely suppressed with or without lactate. Lactate decreased G(ox) from 17.1 +/- 0.4 to 13.4 +/- 1.2 mumol.kg-1.min-1 (p < 0.05), whereas GRd was unchanged (39.7 +/- 3.6 vs 45.6 +/- 2.6 mumol.kg-1.min-1. It is concluded that infusion of lactate in basal conditions does not increase GRa or interfere with peripheral glucose oxidation, and that during hyperinsulinaemia lactate decreases glucose oxidation but does not alter hepatic or peripheral insulin sensitivity. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Peer Reviewed
See detailRadiochirurgie et radiothérapie stéréotaxique
Coucke, Philippe ULg; FANKHAUSER

in Médecine et Hygiène (1995), 53(2088), 2002--2009

La radiochirurgie, appelée radiothérapie stéréotaxique lorsqu'il s'agit d'un traitement fractionné, s'effectue en Suisse depuis 1993, soit par accélérateur linéaire modifié, soit par Gamma Knife. Par ... [more ▼]

La radiochirurgie, appelée radiothérapie stéréotaxique lorsqu'il s'agit d'un traitement fractionné, s'effectue en Suisse depuis 1993, soit par accélérateur linéaire modifié, soit par Gamma Knife. Par cette technique on arrive à administrer une dose élevée de radiations à des lésions intracrâniennes circonscrites d'une taille de 3 à 4 cm au maximum, tout en ménageant les tissus normaux avoisinants. Lorsque les lésions sont plus grandes, mal délimitées, ou de forme irrégulière, c'est la radiothérapie conventionnelle et conformationnelle qui offre une meilleure répartition des doses. Les principales lésions considérées pour la radiochirurgie sont les malformations artérioveineuses, les métastases cérébrales solitaires, les méningiomes de la base, les schwannomes vestibulaires et certaines récidives focales de gliomes. [less ▲]

Detailed reference viewed: 35 (0 ULg)
Peer Reviewed
See detailFear reactions of domestic sheep confronted with either a human or a human-like model
Bouissou, Marie-France; Vandenheede, Marc ULg

in Behavioural Processes (1995), 34

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailIndications et sélection du candidat aux implants
Geerts, Sabine ULg

in Actualités Dentaires de l'Université de Liège (1995), 17

Detailed reference viewed: 26 (5 ULg)
Peer Reviewed
See detailGlucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies.
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1995), 19 Suppl 3

Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for ... [more ▼]

Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for insulin resistance by peripheral hyperinsulinism, the latter resulting from both increased insulin secretion and reduced insulin clearance. Impaired glucose tolerance is observed when insulin resistance is associated to impaired first-phase insulin response, which results in a significant increase in plasma glucose levels and a late insulin hyperresponsiveness. Both hyperinsulinaemia and hyperglycaemia are then able to overcome peripheral insulin resistance and impaired glucose disposal. When a more marked defect in insulin secretion is present, hyperglycaemia progresses, probably due to an additional participation of impaired suppression of hepatic glucose output. Overt diabetes then occurs with persistent post-absorptive hyperglycaemia. All these abnormalities can be reversed after a marked weight loss and recovery of ideal body weight, arguing for acquired rather than inherited metabolic defects in presence of morbid obesity. If a sufficient weight reduction can not be obtained, pharmacological approaches may be considered to improve insulin resistance of obese subjects, especially those with impaired glucose tolerance or overt diabetes. [less ▲]

Detailed reference viewed: 38 (2 ULg)
Full Text
Peer Reviewed
See detailMéthodologie pour une meilleure représentation spatio-temporelle des fluctuations pluviométriques observées au Niger depuis 1905
Ozer, Pierre ULg; Erpicum, Michel ULg

in Sécheresse (1995), 6(1), 103-108

The fluctuations of annual precipitation observed in Niamey and Zinder (Niger) since the turn of the century warranted a comparison of rainfall maps and rainy-season characteristics between 1950-1967 ... [more ▼]

The fluctuations of annual precipitation observed in Niamey and Zinder (Niger) since the turn of the century warranted a comparison of rainfall maps and rainy-season characteristics between 1950-1967 (period of high rainfall) and 1968-1985 (period of low rainfall). Calculating two specific annual spatiotemporal rainfall profiles provided precisions as to the irregular and heterogeneous advance of the drought through Niger. [less ▲]

Detailed reference viewed: 88 (18 ULg)
Full Text
Peer Reviewed
See detailAminoglycoside Antibiotics Induce Aggregation But Not Fusion Of Negatively-Charged Liposomes
Vanbambeke, F.; Tulkens, Pm.; Brasseur, Robert ULg et al

in European Journal of Pharmacology-Molecular Pharmacology Section (1995), 289(2), 321-33

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical ... [more ▼]

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical modifications of the membrane properties. This work examines the capacity of aminoglycosides to induce membrane aggregation and fusion. Three techniques were used in parallel: (i) measurement of the dequenching rate of a lipid-soluble fluorescent probe (octadecylrhodamine B) incorporated at self-quenched concentration in membranes; (ii) measurement of the increase in the energy transfer between two fluorescent derivatives of phospholipids; and (iii) electron microscopy of negatively-stained replicas. The results were compared with those obtained with spermine (an aggregating polycation) and melittin (a fusogenic peptide). The three approaches indicate that aminoglycosides induce liposomes aggregation, but not fusion. Aggregation is related to the capacity of each drug studied to bind phosphatidylinositol, as evaluated by its energy of interaction with this acidic phospholipid, and to its toxic potential. Membrane aggregation occurring in vivo could therefore contribute to, or be a determinant of this toxicity, which could rationally be screened for new derivatives by the methods applied here. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailNew dibenzazepine derivatives with disinhibitory and/or antidepressant potential: neurochemical and behavioural study in the open-field and forced swimming tests.
Bruhwyler, J.; Liégeois, Jean-François ULg; Lejeune, C. et al

in Behavioural pharmacology (1995), 6(8), 830-838

Original bioisosteric analogues of clozapine were evaluated for potential disinhibitory and/or antidepressant effects using the open-field test in the rat and Porsolt's forced swimming test in the mouse ... [more ▼]

Original bioisosteric analogues of clozapine were evaluated for potential disinhibitory and/or antidepressant effects using the open-field test in the rat and Porsolt's forced swimming test in the mouse. Attempts to relate the behavioural results to the binding affinities for dopamine (D1, D2), serotonin (5-HT(2)) and muscarinic (M) receptors were also undertaken. In the open-field test, two main profiles were observed. The first profile corresponded to disinhibitory molecules resembling diazepam and ritanserin. The second profile corresponded to antipsychotic compounds resembling either typical (haloperidol, clothiapine) or atypical (clozapine) neuroleptics. The results obtained in the forced swimming test confirmed the neuroleptic-like activity of the second group of compounds, while two compounds of the first group (JL 3 and JL 26) showed an antidepressant-like activity, JL 3 being as active as imipramine. While it was not possible to relate the first profile to any binding interaction, a relation could be established among the second group of compounds between the typical or atypical antipsychotic behavioural profile and the 5-HT(2)/D2 ratio. [less ▲]

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailMapping quantitative trait loci controlling milk production by exploiting progeny testing
Georges, Michel ULg; Nielsen, D.; Mackinnon, M. et al

in Genetics (1995), 139

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny ... [more ▼]

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding. [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailConfirmation bias as a social skill
Dardenne, Benoît ULg; Leyens, J.

in Personality & Social Psychology Bulletin (1995), 21

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailThe mh gene causing double-muscling in cattle maps to bovine chromosome 2
Charlier, Carole ULg; Coppieters, Wouter ULg; Farnir, Frédéric ULg et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1995), 6

While the hereditary nature of the double-muscling phenotype (a generalized muscular hypertrophy documented in several cattle breeds) is well established, its precise segregation mode has remained ... [more ▼]

While the hereditary nature of the double-muscling phenotype (a generalized muscular hypertrophy documented in several cattle breeds) is well established, its precise segregation mode has remained controversial. Both monogenic models (autosomal dominant or recessive) and oligogenic models have been proposed. Using a panel of 213 bovine microsatellite markers, and an experimental pedigree obtained by backcrossing double-muscled (Belgian Blue)xconventional (Friesian) F1 dams to double-muscled sire, we have mapped a locus on bovine Chromosome (Chr) 2 that accounts for all the phenotypic variance in the backcross generation. This locus, referred to as mh (muscular hypertrophy), has been positioned with respect to a map composed of seven Chr 2-specific microsatellites, at 2 cM from the closest marker. This result confirms the validity in the Belgian Blue population of the monogenic model involving an autosomal mh locus, characterized by a wild-type + and a recessive mh allele, causing the double-muscling phenotype in the homozygous condition. The linkage relationship between the mh locus and the Chr 2 markers was confirmed in three informative pedigrees collected from the general Belgian Blue Cattle population, reinforcing the notion of genetic homogeneity of the double-muscling trait in this breed. This work paves the way towards marker-assisted selection for or against the double-muscling trait, and towards positional cloning of the corresponding gene. [less ▲]

Detailed reference viewed: 70 (8 ULg)
Full Text
Peer Reviewed
See detailUrbanisme commercial et géographie
Merenne-Schoumaker, Bernadette ULg

in Revue Belge de Géographie (1995), 2(59), 307-315

The paper proposes a short reflection on the commercial planning issue. Five points will be considered : a definition of the urban planning field, a presentation of the methodological problems, the ... [more ▼]

The paper proposes a short reflection on the commercial planning issue. Five points will be considered : a definition of the urban planning field, a presentation of the methodological problems, the underscoring of the five major current challenges (new balance city center - out of town, central areas revival, traditional unplanned shopping center maintenance (or revival), local and neighbourhood centers maintenance, out of town developments planning), the first steps towards a new commercial policy, the analysis of the connections between commercial planning and geography. [less ▲]

Detailed reference viewed: 258 (3 ULg)
Peer Reviewed
See detailDecomposing efficiency into its managerial and its regulatory components: The case of European railways
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in European Journal of Operational Research (1995), 80

Detailed reference viewed: 15 (1 ULg)
Peer Reviewed
See detailSpatio-temporal aquatic vegetation patterns in former channels in relation to their isolation from the river Rhine (Eastern France)
Klein, J. P.; Robach, F.; Vanderpoorten, Alain ULg et al

in Acta Botanica Gallica : Bulletin de la Société Botanique de France (1995), 142

Detailed reference viewed: 16 (0 ULg)
See detailKarel Tchapek : humaniste et visionnaire
Mouton, Charles ULg

in Revue Générale (1995), (6/7), 71-80

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailChimiosensibilité in vivo et in vitro de Plasmodium falciparum à Brazzaville (Congo)
Chandenier, Jacques; Ndounga, Mathieu; Carme, Bernard et al

in Santé : Cahiers d'Etude et de Recherches Francophones (1995), 5(1), 25-29

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to ... [more ▼]

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to halofantrine was investigated in an in vitro survey using an isotopic micro test. The resistance rates were 61.8, 14.7, 3.0 and 0.0% respectively. Thus, the chemoresistance which first appeared in 1990 is confirmed and is stable in the population. This finding was further confirmed by a parallel in vitro analysis of sensitivity to chloroquine in Brazzaville. A chloroquine monitoring network is now being established throughout the country based on simplified WHO tests of 100 asymptomatic schoolchildren conducted every six months. The first results in 1993, from three Southern regions indicate that parasites are found in 20 to 60% of cases seven days after a standard 3 day treatment with 25 mg/kg, according to the region. The results of in vitro and in vivo tests are very variable. Indeed, the value of such results for these tests for national monitoring is questionable: a more reliable system of identifying true therapeutic failures would be better suited. [less ▲]

Detailed reference viewed: 39 (1 ULg)
See detailVictor Hugo, "Comme dans les étangs..." : Correction d'un exercice d'analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1995), 27

Detailed reference viewed: 25 (3 ULg)
Peer Reviewed
See detailNonfibrous mineralogical analysis of bronchoalveolar lavage fluid from blast-furnace workers.
CORHAY, Jean-Louis ULg; Bury, Thierry ULg; Delavignette, Jean-Paul ULg et al

in Archives of Environmental Health (1995), 50(4), 312-9

Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We demonstrated previously that steelworkers may be subject to an occult exposure to amphiboles in the plant ... [more ▼]

Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We demonstrated previously that steelworkers may be subject to an occult exposure to amphiboles in the plant environment. In the current study, we further analyzed bronchoalveolar lavage fluid of steelworkers by measuring intramacrophagic trace-metal content and nonfibrous mineral particles, using the particle-induced x-ray emission method and electron microscopy, respectively. Forty-seven blast-furnace workers and 45 healthy white-collar workers volunteered for this study. Significantly increased levels of iron, titanium, zinc, and bromine were found in the steelworkers, and levels of lead, chromium, arsenic, and strontium tended to increase in the macrophages and bronchoalveolar lavage fluid of the steelworkers. Nonfibrous particles, including illite, kaolinite, talc, chlorite, amorphous silica, quartz, iron (compounds), and titanium hydroxide, were found in both groups, but the particle number per ml bronchoalveolar lavage fluid (particularly iron hydroxides and silicates) was more pronounced in blast-furnace workers. These elements and particles may act synergistically with other occupational carcinogens and cigarette smoke, the result of which may be an increased incidence of lung cancer in the ironsteel industry. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Full Text
See detailGlageon: une coupe du Givetien en Avesnois (France). Sédimentologie, Coraux, géologie régionale, diagenèse
Boulvain, Frédéric ULg; Coen-Aubert, M.; Mansy, J. L. et al

in Bulletin de la Société Belge de Géologie (1995), 103(1-2), 171-203

Detailed reference viewed: 49 (4 ULg)
Peer Reviewed
See detailStromelysin-3 - a paradigm of extracellular proteinase expressed in stromal cells of human carcinomas.
Basset, P.; Rouyer, N.; Wolf, C. et al

in Cell Biology International (1995), 19(3), 242-242

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailThe Dissociative Ionization of Carbon Dioxide below 21.22 eV. A high Resolution PIPECO spectroscopic investigation.
Locht, Robert ULg

in International Journal of Mass Spectrometry and Ion Processes (1995), 148

The photoion-photoelectron spectrum of O+, CO+ and CO2+ has been investigated under high resolution conditions. The O+ ion production is found not to be restricted to the CO2+ (C2Sigma+/g,0,0,0 ... [more ▼]

The photoion-photoelectron spectrum of O+, CO+ and CO2+ has been investigated under high resolution conditions. The O+ ion production is found not to be restricted to the CO2+ (C2Sigma+/g,0,0,0) predissociation. The (0,1,0) and (1,0,0) levels are clearly shown to be involved. The CO+ ion production involves all the vibrational states reached in the Franck-Condon region, i.e. up to (2,0,1) at 19.94 eV. The CO2+ molecular ion does not survive the predissociation in the entire range covered in the present work. [less ▲]

Detailed reference viewed: 37 (11 ULg)
Full Text
Peer Reviewed
See detailAnalysis of the open reading frames of the main capsid proteins of actinophage VWB.
Anne, J; Fiten, P; Van Mellaert, L et al

in Archives of Virology (1995), 140(6), 1033-47

The nucleotide sequence of a 6 kb fragment encoding the main late proteins (p14, p38 and p24) of actinophage VWB was obtained. Sequence comparison of the encoded proteins with those filed in databases ... [more ▼]

The nucleotide sequence of a 6 kb fragment encoding the main late proteins (p14, p38 and p24) of actinophage VWB was obtained. Sequence comparison of the encoded proteins with those filed in databases indicated that the phage VWB main late proteins were all novel. A search for special motifs revealed that p14 (13.3 kDa) has a P-loop sequence commonly found in ATP- and GTP-binding proteins. This observation might indicate that p14 is important for ATP-driven DNA translocation during encapsidation of VWB phage DNA into the phage head. Furthermore, the polypeptide ORF2 (26.9 kDa) has an unusual primary structure consisting of 3 stretches of acidic amino acid residues and a glycine/arginine rich C-terminal end. From comparison with other proteins including the bacteriophage T4 prohead core component and from the data of special motif analysis the ORF2 gene product is probably involved in prohead core formation. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailBiological-Activity Of Fenoxycarb Against Sitophilus-Zeamais Motsch (Coleoptera, Curculionidae)
Letellier, C.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Journal of Stored Products Research (1995), 31(1),

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailActivation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin
D'Angelo, Gisela; Struman, Ingrid ULg; Martial, Joseph ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1995), 92(14), 6374-8

A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates ... [more ▼]

A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis. [less ▲]

Detailed reference viewed: 18 (5 ULg)
Full Text
Peer Reviewed
See detailOpera Latina : la banque de données de textes latins du L.A.S.L.A. sur CD-ROM
Purnelle, Gérald ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1995)

Detailed reference viewed: 13 (2 ULg)