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See detailExpérimentation médicale sur l'être humain. Propositions pour un cadre législatif.
Palermini, Patricia ULg; Delfosse, Marie-Luce

in Revue de Droit de la Santé = Tijdschrift voor Gezondheidsrecht (1997), (5), 333-344

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See detailSignes cliniques et diagnostic des tumeurs de la cavité nasale chez le chien: une analyse de 81 cas.
Clercx, Cécile ULg; Peeters, Dominique ULg; Gilbert, S. et al

in Annales de Médecine Vétérinaire (1997), 141

The paper describes clinical signs and diagnosis in 81 cases of intranasal tumors n the dog, examined at the Small Animal Clinic of the Faculty of Veterinary Medicine of the University of Liege (1990-1995 ... [more ▼]

The paper describes clinical signs and diagnosis in 81 cases of intranasal tumors n the dog, examined at the Small Animal Clinic of the Faculty of Veterinary Medicine of the University of Liege (1990-1995). Recent diagnostic techniques and therapeutic options are discussed. The most frequently encountered signs included a decreased or absence of unilateral air passage, observed in 78 cases (96%), and hemorrhagic discharge, observed in 65 cases (80%). Histopathology identified 2 benign and 79 malignant tumors, 57 epithelial and 22 mesenchymatous, including 2 lymphomas. In 74 cases, rhinoscopy identified an intranasal neoplastic mass; in the 7 remaining cases, tissular material of undetermined nature was observed, and histology of biospsied material confirmed the neoplastic nature. The time interval between the diagnosis and the death of the animal (spontaneous or by euthanasia) was longer in dogs with an intranasal sarcoma (mean time interval of 7 months) than in dogs with an intranasal carcinoma (mean time interval of 3 months). [less ▲]

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See detailGenetics and Inflammatory Bowel Disease: From Association Studies to Wide Genome Screen
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1997), 60(3, Jul-Sep), 201-3

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See detailSpectroscopy of Ne IV in the wavelength Range 450–1100 Å
Bastin, Thierry ULg; Biémont, Emile ULg; Dumont, Paul-Dominique ULg et al

in Journal of the Optical Society of America. B, Optical Physics (1997), 14

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution ... [more ▼]

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution that was achieved, with a normal-incidence 2-m spectrometer, was sufficient to identify 53 new Ne IV lines and, consequently, to determine 18 new levels in the quartet and doublet systems and one sextet term. The energy values of 13 additional levels were also revised. The classification work was facilitated by the use of scaled relativistic Hartree–Fock calculations. [less ▲]

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See detailA propos d'un cas de rupture myocardique dans un traumatisme thoracique ferme.
Demarche, M.; SakalihasanN, Natzi ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1997), 52(2), 105-9

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See detailFoaming properties of a natural cyclic lipoheptapeptide belonging to a special class of amphiphilic molecules
Razafindralambo, Hary ULg; Paquot, Michel ULg; Baniel, A. et al

in Food Hydrocolloids (1997), 11(1), 59-62

The foaming properties of surfactin, a natural cyclic lipoheptapeptide from Bacillus subtilis, were investigated in comparison and in association with those of bovine serum albumin (BSA). An apparatus ... [more ▼]

The foaming properties of surfactin, a natural cyclic lipoheptapeptide from Bacillus subtilis, were investigated in comparison and in association with those of bovine serum albumin (BSA). An apparatus combining bubbling, optical and conductimetric methods was used to study continuously foam formation and stability in terms of the quantity and density of foam. The increase in surfactin concentration from 0.05 to 0.2 mg/ml had little effect on its foaming capacity, measured by the bubbling time to produce the required foam volume, but improved the foam maximum density significantly. Surfactin produced foam with higher maximum density and stability, and forms more regular and smaller bubbles than BSA. In addition, a synergistic effect was observed on the stability of liquid in foam prepared with a mixture of 50:50 surfactin/BSA. The liquid half-life of BSA foam was enhanced up to 40% when surfactin was added to the solution. [less ▲]

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See detailHarm avoidance dimension of the Tridimensional Personality Questionnaire and serotonin-1A activity in depressed patients.
Hansenne, Michel ULg; Pitchot, William ULg; Moreno, A. G. et al

in Biological Psychiatry (1997), 42(10), 959-61

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See detailRegolazione della crescité follicolare e luteinica. Folliculogenesi e atresia. Summa.
Drion, Pierre ULg; Beckers, Jean-François ULg; Ectors, Fabien ULg et al

in Summa (1997), 14(9), 5-16

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for ... [more ▼]

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for follicular recruiment. The recruited follicles produce estradiol, inhibin and follistatin which reduce the FSH secretion (negative feed back) reducing their support to hormonodependant follicles which become atresic. The dominant follicle, subjected to internal self stimulation is not sensitive to the reduction in FSH levels and carries on synthesising more and more estradiol. [less ▲]

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See detailDidactique du latin et observation statistique
Denooz, Joseph ULg

in Euphrosyne (1997)

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See detailDetermination of radiative lifetimes of neutral sulphur by time-resolved three-photon VUV laser spectroscopy
Berzinsh, U.; Caiyan, L.; Zerne, R. et al

in Physical Review. A : General Physics (1997), 55

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See detailA Deletion in the Bovine Myostatin Gene Causes the Double-Muscled Phenotype in Cattle
Grobet, L.; Martin, L. J.; Poncelet, D. et al

in Nature Genetics (1997), 17(1), 71-74

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled ... [more ▼]

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-muscle hyperplasia-that is, an increase in the number of muscle fibers rather than in their individual diameter. Although the hereditary nature of the double-muscled condition was recognized early on, the precise mode of inheritance has remained controversial; monogenic (domainant and recessive), oligogenic and polygenic models have been proposed. In the Belgian Blue cattle breed (BBCB), segregation analysis performed both in experimental crosses and in the outbred population suggested an autosomal recessive inheritance. This was confirmed when the muscular hypertrophy (mh) locus was mapped 3.1 cM from microsatellite TGLA44 on the centromeric end of bovine chromosome 2 (ref. 5). We used a positional candidate approach to demonstrate that a mutation in bovine MSTN, which encodes myostatin, a member of the TGF beta superfamily, is responsible for the double-muscled phenotype. We report an 11-bp deletion in the coding sequence for the bioactive carboxy-terminal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle. [less ▲]

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See detailEvidence for enhanced inflammatory cell activity, ICAM-1 expression and eosinophil chemotactic activity in the sputum of asthmatics.
Louis, Renaud ULg; Shute, J.; Biaggi, S. et al

in American Journal of Respiratory & Critical Care Medicine (1997), 155(2), 466-472

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma ... [more ▼]

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects contained increased numbers of eosinophils and levels of eosinophil cationic protein (ECP) and mast cell tryptase. Eosinophil numbers, and ECP and histamine levels correlated with the degree of methacholine airways responsiveness, and ECP, tryptase, and histamine correlated with raised concentrations of albumin. Using the micro-Boyden chamber technique eosinophil chemotactic activity was identified only in the sputum from asthmatics. The correlation between the raised levels of total IgA, IL- 8/IgA complexes, and tryptase and the degree of sputum eosinophilia and ECP levels, suggests possible mechanisms for eosinophil chemotaxis and activation in asthma. Row cytometric analysis of sputum lymphocytes showed an increase in CD4+ T cells and T cells expressing intercellular adhesion molecule-1 (ICAM-1) in asthma which, together with the finding of raised levels of soluble ICAM-1 in the sputum, indicates upregulation of this adhesion molecule. Finally, the proportion of CD16+ natural killer (NK) cells was reduced in the sputum of asthmatics. These observations highlight the importance of the airway inflammation in causing asthma and further confirm the usefulness of sputum induction as a tool in asthma research. [less ▲]

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See detailFungal contamination in barley and Kashin-Beck disease in Tibet
Chasseur, Camille; Suetens, Carl; Nolard, Nicole et al

in Lancet (1997), 350

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See detailAn introduction to ET-LOTOS for the description of time-sensitive systems
Léonard, Luc; Leduc, Guy ULg

in Computer Networks & ISDN Systems (1997), 29(3), 271-292

Enhanced Timed-LOTOS, called ET-LOTOS, is an extension of LOTOS allowing the modelling of time-sensitive systems (i.e. systems whose behaviour is influenced by the passing of time). It is the basis of the ... [more ▼]

Enhanced Timed-LOTOS, called ET-LOTOS, is an extension of LOTOS allowing the modelling of time-sensitive systems (i.e. systems whose behaviour is influenced by the passing of time). It is the basis of the timed extension of LOTOS currently developed by ISO (1995). The purpose of this paper is to present ET-LOTOS in a tutorial style and show its applicability. The detailed study of the formal semantics is addressed in another paper. A collection of small but realistic, examples illustrates a wide variety of time-sensitive protocol mechanisms. These examples are used to introduce and justify the extensions of our language. Finally, the basics of the formal semantics are given and a comparison is made with other timed formalisms. [less ▲]

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See detailL’arsénopyrite du Massif de Stavelot, Belgique
Hatert, Frédéric ULg

in Bulletin de la Société Royale des Sciences de Liège (1997), 66

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See detailLes modes de transmission du virus de l'hépatite C
Delwaide, Jean ULg; Gerard, Christiane ULg; Sondag, Danièle ULg et al

in Revue Médicale de Liège (1997), 52(6), 388-391

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See detailPostoperative spirometry after laparoscopy for lower abdominal or upper abdominal surgical procedures.
Joris, Jean ULg; Kaba, Abdourahmane ULg; Lamy, Maurice ULg

in British Journal of Anaesthesia (1997), 79(4), 422-6

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation ... [more ▼]

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation) (n = 10 in each group) to determine if lower abdominal laparoscopy results in less postoperative pulmonary dysfunction than upper abdominal laparoscopy. Pulmonary testing was performed before operation, and 3 and 6 h after operation, on the first and second days after surgery. After operation, a significant reduction in forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow rate occurred after laparoscopic cholecystectomy at each time. There were no significant changes after minor gynaecologic laparoscopy, whereas laparoscopic gynaecological surgery resulted in minor pulmonary dysfunction on the day of surgery only. We conclude that postoperative pulmonary function was less impaired after gynaecological laparoscopy than after laparoscopic cholecystectomy. This study suggests that the site of surgery is an important determinant of lung dysfunction after laparoscopy. [less ▲]

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See detailBeam-laser measurements and relativistic Hartree-Fock calculations of the lifetimes of the 3d94p levels in Cu II
Pinnington, E. H.; Rieger, G.; Kernahan, J. A. et al

in Canadian Journal of Physics (1997), 75

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See detailDe différences en disparités : les effets d'un système éducatif 'non compréhensif'
Lafontaine, Dominique ULg

in Scientia Paedagogica Experimentalis (1997), XXXIV(2), 267-281

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique ... [more ▼]

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique, organisation en tronc commun ou en filières, présence ou non d'une carte scolaire) et différents indices de performance ou d'équité : performances moyennes en lecture à un test international comparatif, degré d'hétérogénéité des performances entre élèves, disparités de rendement selon l'établissement ou la filière fréquenté(e). Les résultats montrent que le redoublement, largement pratiqué en Communauté française de Belgique, ne débouche ni sur des meilleures performances, ni sur une réduction sensible des disparités entre élèves. L'absence de tronc commun et de sectorisation engendre en outre de fortes disparités selon la filière et selon l'établissement fréquenté. Le premier degré du secondaire de la Communauté française, organisé en système 'non compréhensif', semble ainsi de nature à amplifier plutôt qu'à corriger les inégalités entre élèves issus du primaire. [less ▲]

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See detailIntegrator forwarding : a new recursive nonlinear robust design
Sepulchre, Rodolphe ULg; Jankovic, M.; Kokotovic, Petar V.

in Automatica (1997), 33(5), 979-984

We consider the global stabilization of nonlinear systems in strict feedforward form. We show that these systems, while not feedback linearizable, can be (globally) transformed by feedback and ... [more ▼]

We consider the global stabilization of nonlinear systems in strict feedforward form. We show that these systems, while not feedback linearizable, can be (globally) transformed by feedback and diffeomorphism into a lower-triangular form. The transformation is explicit and recursive. We employ this transformation to design a globally stabilizing controller with optimality properties and an input-to-state stability property with respect to matched uncertainties. [less ▲]

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See detailExamen échographique de l'articulation métacarpo-phalangienne. Corrélation signes échographiques - lésions
Denoix, Jean-Marie; Thill, Emanuelle; Houliez, Didier et al

in Pratique Vétérinaire Equine (1997), 29

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and ... [more ▼]

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and sensitivity and specificity of the technique have been calculated. [less ▲]

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See detailLa vaccination contre les hépatites A et B
Delwaide, Jean ULg; Belaiche, Jacques ULg

in Revue Médicale de Liège (1997), 52(10), 639-643

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See detailExperimental induction of prenucleolar bodies (PNBs) in interphase cells: interphase PNBs show similar characteristics as those typically observed at telophase of mitosis in untreated cells.
Zatsepina, O. V.; Dudnic, O. A.; Todorov, I. T. et al

in Chromosoma (1997), 105(7-8), 418-30

Recently, it was shown that a short exposure of living mammalian cells to low ionic strength buffers (hypotonic shock) caused partial or almost complete unraveling of interphase nucleoli. However, when ... [more ▼]

Recently, it was shown that a short exposure of living mammalian cells to low ionic strength buffers (hypotonic shock) caused partial or almost complete unraveling of interphase nucleoli. However, when the cells were released from the hypotonic shock and transferred to normal isotonic medium, functionally active and structurally integral nucleoli were reassembled at their initial positions within interphase nuclei. Here, we show further that this process is accompanied by the appearance of numerous discrete extranucleolar bodies, which have striking similarities to the prenucleolar bodies (PNBs) observed in untreated cells at telophase of mitosis. (1) Like PNBs at mitosis, hypotonically induced interphase PNBs are composed of RNA-positive granules and fibrils, contain the major nucleolar protein B23 and silver-binding proteins, but lack DNA and RNA polymerase I transcription factor UBF. (2) As for mitotic PNBs, disappearance of the interphase PNB counterparts coincides with the increase in size of reconstructed nucleoli. (3) Addition of actinomycin D does not prevent assembly of interphase PNBs, but does arrest their coalescence with the chromosomal nucleolus-organizing regions and blocks the complete reformation of nucleoli. It is concluded that the assembly of PNBs generally observed at telophase of mitosis can be induced experimentally in nuclei of interphase mammalian cells in vivo. At interphase, this process is probably initiated by changes in the intracellular ionic environment. [less ▲]

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See detailEngraissement du taurillon Blanc-Bleu belge
Minet, Vincent; Van Eenaeme, Christian ULg; Raskin, Pascale et al

in Agricontact (1997), 291

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See detailIdiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature.
Deprez, Manuel ULg; Born, Jacques; Hauwaert, Cécile ULg et al

in Acta Neuropathologica (1997), 94(4), 385-9

A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were ... [more ▼]

A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were suggestive of multiple meningeal neoplasms and a correct diagnosis was made only after meningeal biopsy. This 44-year-old patient had a previous history of an ill-defined systemic disorder associating episcleritis, erythroderma nodosa and multiple peripheral arthritis. We review previous reports of idiopathic cranial pachymeningitis with emphasis on radiological investigation techniques, histopathology and possible dysimmune mechanisms of pathogenesis. [less ▲]

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See detailThe state of stress near the Mendocino triple Junction from inversion of earthquake focal mechanism
Schwartz, S. Y.; Hubert, Aurelia ULg

in Geophysical Research Letters (1997), 23

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See detailLes modes de transmission du virus de l'hépatite C
Delwaide, Jean ULg; Gerard, Christiane ULg; Sondag, Danièle ULg et al

in Médecine & Chirurgie Digestives (1997), 26

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See detailMolecular adaptations of enzymes from psychrophilic organisms
Feller, Georges ULg; Arpigny, J. L.; Narinx, E. et al

in Comparative Biochemistry and Physiology. A : Comparative Physiology (1997), 118(3), 495-499

The dominating adaptative character of enzymes from cold-evolving organisms is their high turnover number (k(cat)) and catalytic efficiency (k(cat)/K-m), which compensate for the reduction of chemical ... [more ▼]

The dominating adaptative character of enzymes from cold-evolving organisms is their high turnover number (k(cat)) and catalytic efficiency (k(cat)/K-m), which compensate for the reduction of chemical reaction rates inherent to low temperatures. This optimization of the catalytic parameters can originate from the highly flexible structure of these proteins providing enhanced abilities to undergo conformational changes during catalysis at low temperatures. Molecular modelling of the 3-D structure of cold-adapted enzymes reveals that only subtle modifications of their conformation can be related to the structural flexibility. The observed structural features include: 1) the reduction of the number of weak interactions involved in the folded state stability like salt bridges, weakly polar interactions between aromatic side chains, hydrogen bonding, arginine content and charge-dipole interactions in alpha-helices; 2) a lower hydrophobicity of the hydrophobic clusters forming the core of the protein; 3) deletion or substitution of proline residues in loops or turns connecting secondary structures; 4) improved solvent interactions with a hydrophilic surface via additional charged side chains; 5) the occurence of glycine clusters close to functional domains; and 6) a looser coordination of Ca2+ ions. No general rule from the molecular changes observed; rather, each enzyme adopts its own strategy by using one or a combination of these altered interactions. Enzymes from thermophiles reinforce the same type of interactions indicating that there is a continuity in the strategy of protein adaptation to temperature. (C) 1997 Elsevier Science Inc. [less ▲]

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See detailColestasis asociada a ticlopidina
Diaz Fuenzalida, A.; VALDES SOCIN, Hernan Gonzalo ULg; Laudano, O. et al

in Gastroenterologia y Hepatologia (1997), 20(3), 128-30

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of ... [more ▼]

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of jaundice, choluria, and itching of one month of evolution. The patient had taken ticlopidine twice a day for 3 months up to one week prior to admission for peripheral arteriopathy. Biopsy was performed showing acinar cholestasis and portal inflammatory infiltrate compatible with cholestasis due to hypersensitivity. Ticlopidine was discontinued by the patient himself one week prior to admission. The drug was not readministered and the evolution of the clinical and biochemical parameters of cholestasis decreased. The patient was asymptomatic and laboratory data were normal 4 months later. [less ▲]

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See detailMotivation des jeunes à la pratique des activités physiques et sportives
Ledent, Maryse; Cloes, Marc ULg; Onofre, C. Jordan et al

in Sport (1997), 159/160

Nombreux sont ceux qui attribuent une importance capitale aux motivations à la participation des jeunes au sport. En effet, les modalités de pratique et la qualité des expériences vécues dans le domaine ... [more ▼]

Nombreux sont ceux qui attribuent une importance capitale aux motivations à la participation des jeunes au sport. En effet, les modalités de pratique et la qualité des expériences vécues dans le domaine des activités physiques et sportives exerceraient de profonds effets dans la perspective d'un style de vie actif et sain à l'âge adulte. Cette croyance, bien établie chez les éducateurs physiques et les partisans du sport, doit néanmoins être prise avec beaucoup de prudence lorsque l'on considère les résultats des études longitudinales. ... [less ▲]

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See detailRecommandations pour la prévention de l’infection tuberculeuse dans les institutions de soins
Gosset, Christiane ULg; Prignot, J.; Schandevyl, W. et al

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (1997), 24(1), 50-56

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See detailLe cas clinique du mois, A propos d'un cas de myelinolyse centropontique chez un éthylique chronique
Lebrun, F.; Lambermont, Bernard ULg; Ghuysen, Alexandre ULg et al

in Revue Médicale de Liège (1997), 52(1), 7-11

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See detailOrigine des produits animaux et empreinte génétique
Portetelle, Daniel ULg; Mortiaux, Frédéric; Burny, Arsène et al

in Agricontact (1997), 294

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See detailAnti-PMSG in sheep subjected annualy to oestrus synchronisation
Bodin, L.; Drion, Pierre ULg; Remy, Benoit et al

in Reproduction Nutrition Development (1997), 37

Estimation of the long-term consequences on reproduction performance of the oestrus synchronisation treatments that are annually applied to ewes was carried out on nine officially controlled dairy flocks ... [more ▼]

Estimation of the long-term consequences on reproduction performance of the oestrus synchronisation treatments that are annually applied to ewes was carried out on nine officially controlled dairy flocks in the Roquefort region of France. A hormonal treatment combining the insertion of a vaginal fluoro-gestone acetate (FGA) sponge for 14 days and the injection of about 500 IU of pregnant mare serum gonadotropin (PMSG) at withdrawal was applied to the ewes in seven of the nine flocks. The ewes in the two other flocks were used as controls. Blood samples were taken from each female just before the treatment (to test for the presence of residual antibodies) and 20 days after the PMSG injection. Anti-PMSG antibody binding rates were calculated for each blood sample. The residual binding rate increased with age and induce negative effects on the following years reproduction performances, ie, they increased the probability that the ewes would not become pregnant. [less ▲]

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See detailPirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties.
Bruhwyler, J.; Liégeois, Jean-François ULg; Geczy, J.

in Pharmacological Research (1997), 36(1), 23-33

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical ... [more ▼]

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical irreversible monoamine oxidase inhibitors. Its main mechanism of action consists of a selective and reversible inhibition of monoamine oxidase A. Secondarily, it exerts an inhibitory effect on noradrenaline and 5-hydroxytryptamine reuptakes. It has no effect on the dopaminergic and cholinergic systems. It has only a low potential for amplifying tyramine and noradrenaline pressor effect, which makes one expect that it will not be at the basis of a 'cheese effect'. Pirlindole has an absolute bioavailability of between 20 and 30% due to an extensive first-pass effect. Orally, the Tmax varies between 2.5 and 6 h in the rat and 0.8 and 2 h in the dog. Two phases of elimination (7.5 and 34-70 h) are measured in the rat and three phases in the dog (1.3, 10.8 and 185 h); it is extensively metabolized. The rat eliminates mainly unconjugated products while the dog eliminates mostly conjugated products. Acute and chronic toxicological studies have not revealed potentially dangerous effects of the drug at the usual doses. It does not present measurable mutagenic, clastogenic or carcinogenic properties. Thus, pirlindole shows pharmacological, pharmacokinetic and toxicological properties which make it suitable for the management of depression. [less ▲]

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See detailTrois ivoires médiévaux au Musée de l’Oeuvre Notre-Dame à Strasbourg
Van den Bossche, Benoît ULg

in Cahiers Alsaciens d’Archéologie, d’Art et d’Histoire (1997), XL

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See detailThe role of bisphosphonates in the treatment of osteoporosis
Reginster, Jean-Yves ULg; Halkin, V.; Gosset, Christiane ULg et al

in Drugs of Today (Barcelona, Spain : 1998) (1997), 33

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See detailMesures d'incitation en faveur de la conservation de la diversite genetique en matiere agricole. 2. Analyse des mesures agri-environnementales belges.
Lepoivre, Philippe ULg; Baltus, Carine

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(3), 187-195

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See detailEn mai élis qui te plaît
Durand, Pascal ULg

in Liège Université (1997), (été), 3

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See detailHair follicle involvement in herpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Virchows Archiv : An International Journal of Pathology (1997), 430

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See detailEssai comparatif de deux antalgiques, la floctafénine et le paracétamol, au cours de l’arthrose des membres inférieurs
Lequesne, M; Fannius, J; Reginster, Jean-Yves ULg et al

in Revue du Rhumatisme (1997), 64(5), 349-355

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See detailGlucose turnover in humans in the basal state and after intravenous glucose: a comparison of two models.
Overkamp, D.; Gautier, J. F.; Renn, W. et al

in American Journal of Physiology (1997), 273(2 Pt 1), 284-96

This study investigated the ability of two models to represent glucose kinetics in the basal steady state and during an intravenous glucose tolerance test (IVGTT). Six young nonobese male subjects were ... [more ▼]

This study investigated the ability of two models to represent glucose kinetics in the basal steady state and during an intravenous glucose tolerance test (IVGTT). Six young nonobese male subjects were studied after an overnight fast. Two bolus injections of [U-13C]glucose were given 150 min apart, the first without and the second together with concomitant injection of unlabeled glucose. [3-3H]glucose was constantly infused throughout the study and served to provide an independent means for evaluation of system responses. A linear time-invariant three-compartmental model and the two-compartment time-variant model proposed by Caumo and Cobelli were used to interpret measured time courses of [U-13C]glucose and to reconstruct endogenous glucose production and glucose removal. The ability of the two models to describe the glucose tracer time course was comparable. Simulation studies showed that the two-compartmental time-variant system better predicted measured [3-3H]glucose concentration profiles than did the three-compartmental time-invariant model. However, endogenous glucose production and the integral of excess glucose removal over basal during the IVGTT derived from the two models were almost identical. [less ▲]

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See detailMitochondrial Asparaginyl-Trna Synthetase Is Encoded By The Yeast Nuclear Gene Ycr24c
Landrieu, I.; Vandenbol, Micheline ULg; Hartlein, M. et al

in European Journal of Biochemistry (1997), 243(1-2),

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See detailInfluence du climat sur l'évolution de la population de tétras lyres Tetrao tetrix dans les Hautes-Fagnes de Belgique de 1967 à 1996
Loneux, Michèle ULg; Lindsey, James ULg; Ruwet, Jean-Claude

in Cahiers d'Ethologie (1997), 17(2-3-4), 345-386

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See detailRegolazione della crescité follicolare e luteinica. Ovulazione, corpo luteo e luteolisi
Drion, Pierre ULg; Ectors, Fabien; Hanzen, Christian ULg et al

in Riproduzione dei Ruminanti (1997), 14(9), 17-25

Most ovarian follicles (99.9%) will end up with follicular atresia. During antral stages atresia depends on a reduction of FSH levels secondary to estradiol and inhibin secretions by the dominant follicle ... [more ▼]

Most ovarian follicles (99.9%) will end up with follicular atresia. During antral stages atresia depends on a reduction of FSH levels secondary to estradiol and inhibin secretions by the dominant follicle. Plasma levels in estradiol higher than 12pg/ml for at least 12 hours in bovine will cause the reversal of the negative feed-back effect of estradiol on the hypothalamus inducing the preovulatory peak of LH. So that the ovulatory discharge does not occur prematurely, the dominant follicle also secretes GnSIF which desensitises the hypohtesis to the action of GnRH. After ovulation, the corupus luteum, a true endocrine gland, develops. [less ▲]

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See detailPost-operative adjuvant therapy for non-small-cell lung cancer
Barthelemy, Nicole ULg; Johnson; Arriagada et al

in Lung Cancer (1997), 17(supp 1),

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See detailDevelopment of a positron emission tomography radiopharmaceutical for imaging thymidine kinase gene expression : Synthesis and in vitro evaluation of 9-{3-[18F] Fluoro-1-hydroxy-2-propoxymethyl guanine
Monclus, Michel; Luxen, André ULg; Cool, Vincent et al

in Bioorganic and Medicinal Chemistry Letters (1997), 7(14), 1879-1882

9-[(3-fluoro-1-hydroxy-2-propoxy)methyl]guanine (FHPG) 2 has been labeled with fluorine-18 and evaluated in vitro as a potential radiotracer for mapping gene expression in vivo with positron emission ... [more ▼]

9-[(3-fluoro-1-hydroxy-2-propoxy)methyl]guanine (FHPG) 2 has been labeled with fluorine-18 and evaluated in vitro as a potential radiotracer for mapping gene expression in vivo with positron emission tomography (PET). [less ▲]

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See detailL'article 185, alinéa 2, du Code civil et les opérations sur titres
Partsch, Philippe-Emmanuel ULg

in Revue Pratique des Sociétés (1997)

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See detailPemphigus foliacé dans l'espèce équine : synthèse et description de 2 cas.
Amory, Hélène ULg; Beco, Luc; Desmecht, Daniel ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailGenetic Structure Of A Lima Bean Base Collection Using Allozyme Markers
Maquet, A.; Bi, Iz.; Delvaux, M. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1997), 95(5-6),

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See detailNote sous Cassation, 7 mai 1996
Orban, Lionel ULg

in Actualités du Droit (1997)

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See detailKlanknabootsingen in strips
Meesters, Gert ULg

in Nederlands van nu (1997), 45(3), 82-83

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See detailExtensive Ulcerative Colitis and Extraintestinal Manifestations in a Patient with Hiv Infection and Significant Cd4 T-Cell Lymphopenia
Louis, Edouard ULg; Moutschen, Michel ULg; de Marneffe, Pierre et al

in Gastroentérologie Clinique et Biologique (1997), 21(11), 884-7

We report a heterosexual patient with HIV infection and a CD4 T-cell count of 0.45 x 10(9)/L who developed mild ulcerative proctitis, sacroileitis and oligoarthiritis. While he was treated with 5 ... [more ▼]

We report a heterosexual patient with HIV infection and a CD4 T-cell count of 0.45 x 10(9)/L who developed mild ulcerative proctitis, sacroileitis and oligoarthiritis. While he was treated with 5-aminosalicylic enemas, the patient rapidly developed severe pancolitis. An emergency colectomy without procetectomy was performed. A few months later, he suffered recurrence of ulcerative proctitis, aggravation of arthritic pain and developed anterior uveitis. All symptoms disappeared after proctectomy. There was no evidence for opportunistic infection or Kaposi's sarcoma. Antineutrophil cytoplasmic antibodies were positive and the HLA-B27 antigen was present. CD4 counts were lower during the phases of active disease than during remission. This case demonstrates that severe ulcerative colitis can occur in the presence of moderate T-cell defects. In view of a recent report of remission of Crohn's disease under comparable circumstances, it is possible that the extent of T-cell involvement in both diseases is radically different. [less ▲]

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See detailLa responsabilité civile et professionnelle des administrateurs
Caprasse, Olivier ULg

in Actualités du Droit (1997)

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See detailInventaire forestier régional et applications cartographiques.
Rondeux, Jacques ULg; George, B.; Lecomte, Hugues

in Silva Belgica (1997), 104(3),

Il est pratiquement possible de représenter, par voie cartographique, tous les résultats issus d'un inventaire réalisé par échantillonnage, que ce soit en termes de variables quantitatives réparties en ... [more ▼]

Il est pratiquement possible de représenter, par voie cartographique, tous les résultats issus d'un inventaire réalisé par échantillonnage, que ce soit en termes de variables quantitatives réparties en classes d'amplitudes fixées ou de variables qualitatives codées sur une échelle de valeurs prédéfinie. A la condition d'être de type systématique [RONDEUX, 1993], cet échantillonnage assure une représentation cartographique homogène d'autant plus fine, lisible et fiable que la maille définissant l'emplacement des unités de sondage est dense et que la variabilité de l'élément ou de la variable à illustrer est faible. La localisation géographique de l'information, en particulier forestière, permet de donner une autre dimension aux résultats et offre d'évidentes perspectives de valorisation de ceux-ci, en particulier lorsqu'il s'agit de problèmes relevant de la gestion de l'espace et de stratégies touchant son organisation à une large échelle. Ces propos sont illustrés par la réalisation de cartes relatives à une situation photographiée par le premier inventaire forestier wallon mis en oeuvre [RONDEUX, 1988] entre 1980 et 1984. Elles concernent, à titre d'exemple et compte tenu des contraintes exposées au paragraphe 2, la répartition entre propriétés publiques et privées, les types de peuplement (feuillus ou résineux) et la structure de ceux-ci, les volumes à l'hectare de la totalité du matériel ligneux vivant et les niveaux de productivité des peuplements d'épicéa commun. Nous envisagerons sur un plan général le type de relations unissant un inventaire par échantillonnage à une représentation cartographique thématique (paragraphe 2), nous présenterons ensuite les documents proposés après avoir précisé la définition aussi stricte que possible des variables entrant en ligne de compte (paragraphe 3) avant de terminer par une brève conclusion (paragraphe 4). [less ▲]

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See detailEstimation of (co)variance components for Jersey type traits using a repeatability model
Gengler, Nicolas ULg; Wiggans, G. R.; Wright, J. R. et al

in Journal of Dairy Science (1997), 80(8), 1801-1806

(Co)variance components for final score and 15 linear type traits of Jersey cows were estimated by multitrait REML using multiple diagonalization and a repeatability model with 34,999 records of 22,354 ... [more ▼]

(Co)variance components for final score and 15 linear type traits of Jersey cows were estimated by multitrait REML using multiple diagonalization and a repeatability model with 34,999 records of 22,354 cows. Multiple diagonalization gave relative off-diagonals (ratio of squared off-diagonals to the product of diagonals) of <0.1%. Heritabilities and repeatabilities, respectively, were estimated as 0.29 and 0.48 for final score, 0.40 and 0.57 for stature, 0.26 and 0.39 for strength, 0.28 and 0.43 for dairy form, 0.13 and 0.25 for foot angle, 0.13 and 0.25 for rear legs (side view), 0.27 and 0.41 for body depth, 0.31 and 0.52 for rump angle, 0.22 and 0.33 for thurl width, 0.22 and 0.36 for fore udder attachment, 0.28 and 0.46 for rear udder height, 0.26 and 0.42 for rear udder width, 0.32 and 0.48 for udder depth, 0.20 and 0.36 for udder cleft, 0.29 and 0.46 for front teat placement, and 0.31 and 0.48 for teat length. Estimates of heritability generally were higher, and estimates of repeatability were lower, than values used previously for USDA genetic evaluations, which were based on data from the 1970s and early 1980s. Final score was highly correlated both genetically and phenotypically with dairy form and rear udder traits. These estimates of heritabilities and (co)variance components are necessary for multitrait genetic evaluation of linear type traits of US Jerseys. [less ▲]

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See detailSoluble and cell-associated transferrin receptor in lung cancer.
Dowlati, A.; Loo; Bury, Thierry ULg et al

in British Journal of Cancer (1997), 75(12), 1802-6

The expression of transferrin receptor (TfR) has been identified in many malignant tumours. In lung cancer, lymphoma and breast cancer, it has been shown that the expression of TfR correlates with tumour ... [more ▼]

The expression of transferrin receptor (TfR) has been identified in many malignant tumours. In lung cancer, lymphoma and breast cancer, it has been shown that the expression of TfR correlates with tumour differentiation, probably implying some prognostic value. A soluble form of TfR (sTfR) in human serum has been shown to be proportional to the number of cellular TfRs. Based on these data we examined the utility of measuring sTfR in the serum and bronchoalveolar lavage (BAL) fluid of patients with lung cancer (n = 32) and patients with chronic obstructive pulmonary disease (n = 22). BAL fluid was centrifuged to separate the supernatant from the cellular component. Cells were lysed in a detergent and cell-associated TfR was measured by enzyme-linked immunosorbent assay (ELISA) and expressed as ng 10(-6) cells in this cellular component. There was no difference in serum sTfR between the cancer and chronic obstructive pulmonary disease (COPD) groups. A higher level of cell-associated TfR was found in BAL of non-small-cell lung cancer patients than in COPD patients (P = 0.01). The calculated number of TfR molecules per cell in BAL correlated positively with the percentage of macrophages in BAL (P < 0.0001), suggesting that cell-associated TfR in BAL originates primarily from macrophages in this fluid. No correlation existed between BAL cell-associated TfR and tumour size, nodal status, the presence of metastases and serum sTfR. BAL cell-associated TfR was negatively correlated with BAL supernatant neuron-specific enolase (NSE) (P = 0.01). A combination of BAL supernatant NSE and cell-associated TfR detected lung cancer with a sensitivity of 91%, a specificity of 59% and positive and negative predictive values of 81% and 71% respectively. In conclusion, BAL cell-associated TfR may help in the differential diagnosis of lung cancer vs pneumonia. [less ▲]

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See detailChanges in the Western Boundary Undercurrent outflow since the Last Glacial Maximum, from smectite/illite ratios in deep Labrador Sea sediments
Fagel, Nathalie ULg; Hillaire-Marcel; Robert, Christian

in Paleoceanography (1997), 12(1), 79-96

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador ... [more ▼]

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador Rise) of the Western Boundary Undercurrent (WBUC) gyre. At the two sites, smectites transported from the eastern Iceland and Irminger basins by the WBUC are observed. Clay mineral changes are used as proxies for the paleointensity reconstruction of the WBUC. On the Greenland Rise, a clay mineral index (smectite/illite (S/I) ratio) is defined. A S/I ratio of similar to 1 characterized the Last Glacial Maximum. It increased after similar to 17 ka, and reached a maximum value of 4 during the early Holocene, The mineralogical changes are gradual and do not show any reversal during the Younger Dryas, This pattern, which is confirmed by first-order estimations of smectite and illite fluxes, suggests gradually increasing sedimentary fluxes and WBUC intensity since the Last Glacial Maximum, A peak in the velocity of the WBUC at similar to 9 ka, as recorded by clay assemblages, is consistent with other regional studies based on pollen, foraminifera, or grain-size measurements, A massive dilution of smectites by illite and chlorite (S/I approximate to 3) occurs at similar to 8.5 ka. It corresponds to a period of rapid sediment accumulation and reflects an intensified illite-rich detrital supply by meltwaters from the southern Greenland Ice Margin. On the Labrador Rise, the smectite content varies between 20 and 60% with no obvious trend through time. The mineralogical composition is strongly influenced by ice-rafted deposition and by the abundance of fast deposit units (cf, Heinrich layers in the North Atlantic) which contain abundant detrital carbonates spilled-over from the North-West Atlantic Mid-Ocean Channel. In such layers, smectites are present but are diluted by the addition of illites, chlorites, and kaolinites. This provides evidence for a discrete and continuous WBUC supply of fine particles from the Irminger and Iceland Basins as far as the southeastern part of the Labrador Basin, Early deglacial smectite-rich layers (up to 60%) are also observed at this site, They indicate an increase in the outflow of the WBUC at similar to 13.5 ka, (Bolling-Allerod), as previously reported from grain size or foraminiferal assemblage studies. [less ▲]

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See detailEvidence For The Assignment Of Two Strains Of Splv To The Genus Potyvirus Based On Coat Protein And 3' Non-Coding Region Sequence Data
Colinet, Dominique; Kummert, Jean; Lepoivre, Philippe ULg

in Virus Research (1997), 49(1), 91-100

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See detailAlteration of radiation response in vitro by simultaneous modulation of the de novo and salvage pathways to deoxynucleoside triphosphate pool by (E)-2′-Deoxy-(Fluoromethylene)cytidine and thymidine analogs
Coucke, Philippe ULg; Li, Ye-Xiong; Cottin, Eliane et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 39(2 (supp1)), 257

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See detailNumerical simulation of a quantum particle in a box
Hermann, Raphaël ULg

in Journal of Physics : A Mathematical & General (1997), 30(11), 3967-3975

It is shown how one can get numerical prediction of quantum mechanical particle behaviour without using the Schrodinger equation. The main steps of this development are the non-differentiability ... [more ▼]

It is shown how one can get numerical prediction of quantum mechanical particle behaviour without using the Schrodinger equation. The main steps of this development are the non-differentiability hypothesis, the equations of motion entailed by this hypothesis, and the numerical formulation of a simple one-dimensional problem: the particle in a box. [less ▲]

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See detailApplication of canonical transformation with missing values to multitrait evaluation of Jersey type
Gengler, Nicolas ULg; Wiggans, G. R.; Wright, J. R. et al

in Journal of Dairy Science (1997), 80(10), 2563-2571

A multitrait animal model was used to calculate predicted transmitting ability and reliabilities for final score and 15 linear type traits of 225,632 US Jersey cows. Records were adjusted for age and ... [more ▼]

A multitrait animal model was used to calculate predicted transmitting ability and reliabilities for final score and 15 linear type traits of 225,632 US Jersey cows. Records were adjusted for age and stage of lactation before analysis. The model contained effects for interactions of herd and date scored; year scored, parity, and age; and herd and sire; effects of permanent environment and additive genetics were also included. Of the 381,511 records included, some observations were missing for final score (8%), body depth (43%), and teat length (33%). The evaluation system used a canonical transformation, included several random effects, and estimated missing values with each iteration. Inbreeding was considered in the computations. Convergence was achieved in approximately 50 rounds of iteration. Correlations between animal and sire model predicted transmitting ability ranged from 0.56 to 0.95 and generally were higher for bulls than for cows and for more recent birth years. Genetic trend was strongly positive for dairy form, final score, and rear udder traits (height and width) and negative for udder depth. For other traits, genetic trend was small. This methodology should improve the accuracy of genetic evaluations for type traits of US Jerseys. [less ▲]

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See detailElectrospray Mass Spectrometry Study of Selective Complexes of Polyammonium Macrotricyclic Ligands with Dicarboxylic Acids
Collette, Caroline ULg; Meunier, Cécile; De Pauw, Edwin ULg et al

in Rapid Communications in Mass Spectrometry : RCM (1997), 11

Macrocyclic and macropolycyclic polyammonium host molecules have been shown to complex a variety of inorganic and organic anions strongly and selectively. The selectivity of the complexation depends on ... [more ▼]

Macrocyclic and macropolycyclic polyammonium host molecules have been shown to complex a variety of inorganic and organic anions strongly and selectively. The selectivity of the complexation depends on the substrate lenght and on the size of the host cavity of the macrocycle. We describe in this article the analysis of the complexation of dicarboxylic acid substrates by a macrotricyclic host using electrospray mass spectrometry. [less ▲]

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See detailChanging sensitivity to duration in human scalar timing: An experiment, a review, and some possible explanations
Ferrara, André ULg; Lejeune, Helga ULg; Wearden, J. H.

in Quarterly Journal of Experimental Psychology. B, Comparative & Physiological Psychology (1997), 50B

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See detailFusion Of Bovine Leukemia Virus With Target Cells Monitored By R18 Fluorescence And Pcr Assays
Zarkik, S.; Defrisequertain, F.; Portetelle, Daniel ULg et al

in Journal of Virology (1997), 71(1),

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See detailJustinien et la langue latine. A propos d'un prétendu oracle rendu à Romulus d'après Jean le Lydien
Rochette, Bruno ULg

in Byzantinische Zeitschrift (1997), 90(2), 413-415

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See detailDes auteurs dans les ruines. Parcours arbitraire
Delhalle, Nancy ULg

in Alternatives Théâtrales (1997)

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See detailPresence of pap-, sfa- and afa-related sequences in necrotoxigenic Escherichia coli isolates from cattle : evidence for new variants of the AFA family
Mainil, Jacques ULg; Jacquemin, E.; Hérault, F. et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1997), 61

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See detailHerpesvirus Of Turkeys Homologue Of Hsv Vp16 Is Structurally Related To Varicella Zoster Virus Trans-Inducing Protein Encoded By Orf 10
Kopacek, J.; Zelnik, V.; Brasseur, Robert ULg et al

in Virus Genes (1997), 15(1), 45-52

Expression of the immediate-early genes of alpha-herpesviruses is stimulated by a family of trans-inducing factors represented by VP16 of HSV-1 and ORF10 gene product of VZV. We have identified and ... [more ▼]

Expression of the immediate-early genes of alpha-herpesviruses is stimulated by a family of trans-inducing factors represented by VP16 of HSV-1 and ORF10 gene product of VZV. We have identified and determined the nucleotide sequence of the UL48 gene encoding the herpesvirus of turkeys (HVT) homologue of HSV VP16. The gene maps to the BamHI-J fragment and appears to be expressed in a form of bicistronic transcript together with UL49. The deduced amino acid sequence of the protein encoded by HVT UL48 gene shows 55% identity with MDV UL48 gene product. Like the majority of related proteins in other alpha-herpesviruses, the protein encoded by HVT UL48 gene lacks the acidic C-terminal tail, known to possess the transactivation capacity of HSV VP16. Hydrophobic cluster analysis has revealed that its predicted domain composition is closely related to the transactivator protein encoded by ORF10 of VZV. However, the putative amino-terminal activation domain of the HVT homologue of HSV VP16 does not contain a typical horseshoe-like hydrophobic cluster found in other alpha-herpesvirus homologues, suggesting either that it acts as a transactivator via a different activation domain or that its transactivation potential is diminished. [less ▲]

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See detailDensity-functional theory of polar insulators
Gonze, X.; Ghosez, Philippe ULg; Godby, R. W.

in Physical Review Letters (1997), 78(2), 294-297

We examine the density-functional theory of macroscopic insulators, obtained in the large-cluster limit or under periodic boundary conditions. For polar crystals, we find that the two procedures are not ... [more ▼]

We examine the density-functional theory of macroscopic insulators, obtained in the large-cluster limit or under periodic boundary conditions. For polar crystals, we find that the two procedures are not equivalent. In a large-cluster case, the exact exchange-correlation potential acquires a homogeneous ''electric field'' which is absent from the usual local approximations, and the Kohn-Sham electronic system becomes metallic. With periodic boundary conditions, such a field ist forbidden, and the polarization deduced from Kohn-Sham wave functions is incorrect even if the exact functional is used. [less ▲]

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See detailPerspective in the treatment of insulin resistance.
Scheen, André ULg

in Human Reproduction (1997), 12 Suppl 1

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including ... [more ▼]

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including upper body adiposity, glucose intolerance, hypertension, dyslipidaemia, etc.) in industrialized countries and its dramatic consequences for public health. Insulin sensitivity can be improved by non-pharmacological means, essentially reduction of excessive body weight, promotion of regular physical activity and modification of dietary habits, as well as, possibly, cessation of smoking and correction of subclinical magnesium deficiency. Currently available pharmacological means mainly include the biguanide compound metformin and possibly anti-obesity agents, such as (d-) fenfluramine, fluoxetine and benfluorex. New compounds aiming at improving the action of insulin are in development, especially the thiazolidinedione derivatives (e.g. troglitazone), known as 'insulin sensitizers'. Treatment of insulin resistance may have important gynaecological applications, essentially in polycystic ovary syndrome and, possibly, after menopause. Hopefully, improving insulin sensitivity could ameliorate the cardiovascular prognosis of numerous individuals having some or all components of insulin resistance syndrome. [less ▲]

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See detailDamping rates of hard momentum particles in a cold ultrarelativistic plasma
Vanderheyden, Benoît ULg; Ollitrault, J. Y.

in Physical Review. D : Particles and Fields (1997), 56(8), 5108-5122

We compute the damping rates of one-particle excitations in a cold ultrarelativistic plasma to leading order in the coupling constant e for three types of interaction: Yukawa coupling to a massless scalar ... [more ▼]

We compute the damping rates of one-particle excitations in a cold ultrarelativistic plasma to leading order in the coupling constant e for three types of interaction: Yukawa coupling to a massless scalar boson, QED, and QCD. Damping rates of charged particles in QED and QCD are of order e(3) mu, while the damping rates of other particles are of order e(4) mu or e(4) mu log(1/e). We find that the damping rate of an electron or of a quark is constant far from the Fermi surface, and decreases linearly with the excitation energy close to the Fermi surface. This unusual behavior is attributed to the long-range magnetic interactions. [less ▲]

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See detailDe l’acyclovir au valacyclovir: la biodisponibilité en plus de l’efficacité et de la tolérance
Rentier, Bernard ULg

in Virologics (1997), (Septembre), 10-11

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See detailDifferential expression of galectin 3 and galectin 1 in colorectal cancer progression.
Sanjuan, X.; Fernandez, P. L.; Castells, A. et al

in Gastroenterology (1997), 113(6), 1906-15

BACKGROUND & AIMS: Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and ... [more ▼]

BACKGROUND & AIMS: Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS: Galectin 3 expression was examined immunohistochemically in 39 samples of normal mucosae, 25 adenomas, 87 carcinomas, and 39 lymph node metastases. Galectin 1 was analyzed in 25 samples of mucosae, 15 adenomas, 25 carcinomas, and 11 metastases. Western blot analysis was also performed. RESULTS: All normal mucosae showed strong nuclear galectin 3 expression, which was down-regulated in the neoplastic progression, because only 60% of adenomas, 48% of carcinomas, and 44% of metastases were strongly positive (P < 0.0001). Cytoplasmic expression was down-regulated in adenomas (16%) but increased again in carcinomas (64%) (P < 0.0001). Galectin 1 expression was mainly detected in stromal cells and correlated with tumor progression from normal mucosae to adenomas and carcinomas (P < 0.0001). CONCLUSIONS: Galectin 3 expression is down-regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Galectin 1 in colorectal mucosa is predominantly a stromal product whose overexpression is associated with the neoplastic progression of colorectal cancer. [less ▲]

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See detailThe Burden of Hypopituitarism in Adults after Pituitary Surgery
Van Roijen, L.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Journal of Clinical Endocrinology and Metabolism (1997), 4(Suppl. B), 139-142

The burden of illness was assessed in 183 hypopituitary patients, with growth hormone deficiency, who had received pituitary surgery at the Centre Hospitalier Universitaire de Liège, Belgium. The Short ... [more ▼]

The burden of illness was assessed in 183 hypopituitary patients, with growth hormone deficiency, who had received pituitary surgery at the Centre Hospitalier Universitaire de Liège, Belgium. The Short-Form 36 (SF-36) was used to assess health status, and the Health and Labour Questionnaire was used to obtain data on production loss and reduced labout performance. Data on medical consumption were also collected. The overall response rate was 72 %. Hypopituitary patients reported a lower health status than that of the mean population in all but two dimensions of the SF-36 (bodily pain and physical functioning). A relativelu high percentage of hypopituitary patients reported being incapacitated for paid employment, and those in paid employment reported higher absence rates compared with reference data. However, while at work there was no indication that hypopituitary patients perform less well due to health problems than the average population. Healthcare costs for hypopituitary patients who had undergone pituitary surgery were higher than for the reference population. [less ▲]

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See detailLinear Benard-Marangoni instability in rigid circular containers
Dauby, Pierre ULg; Lebon, Georgy ULg; Bouhy, E.

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 56(1), 520-530

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See detailRelationships of growth hormone gene and milk protein polymorphisms to milk production traits in Simmental cattle
Falaki, M.; Prandi, A.; Corradini, C. et al

in Journal of Dairy Research (1997), 64(1), 47-56

The importance of milk proteins and the positive effect of administration of growth hormone (GH) on milk production, and the presence in some dairy cattle lines of greater GH concentrations prompted us to ... [more ▼]

The importance of milk proteins and the positive effect of administration of growth hormone (GH) on milk production, and the presence in some dairy cattle lines of greater GH concentrations prompted us to examine the presence of restriction fragment length polymorphism at the GH gene using the restriction enzyme TaqI and to investigate associations between this polymorphism in Simmental cows and bulls, as well as milk protein variants in Simmental cows, and milk production traits. Blood and milk were sampled from 279 Italian Simmental cows and semen was collected from 148 bulls of the same breed. Two fragment bands, denoted A and B, of 6200 and 5200 bp respectively, were examined and three patterns, AA, AB and BB, were found in both animal samples. All variants previously reported in other studies, for kappa, beta, and alpha(s1)-caseins, and beta-lactoglobulin, were found in the cows' samples. For the cows' samples, a BLUP (Best Linear Unbiased Predictor) analysis of results was performed using a REML (Restricted Maximum Likelihood) program and known heritabilities, whereas for bulls we have performed a General Linear Model analysis. The effect of GH gene polymorphism, using TaqI restriction enzyme, on milk production traits was not significant, but bulls of BB pattern had a higher breeding value for milk yield than AA bulls (P < 0.05). For the kappa-casein genotypic effects, cows of AB genotype gave milli with 1.53+/-0.70 g/kg less fat than cows of AA genotype. In addition, breeding values for milk protein content were significantly higher in BB bulls, with 0.87+/-0.32 and 0.71+/-0.34 g/kg more milk protein than AA and AB bulls respectively. Thus, our results revealed a GH gene polymorphism and indicated significant effects of milk protein polymorphisms on milk production traits in the Italian Simmental breed. [less ▲]

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See detailTell Amarna 1997
Tunca, Önhan ULg

in Chronique archéologique en Syrie 2 (1997)

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See detailFatal Mural Endocarditis and Cutaneous Botryomycosis after Heart Transplantation
Defraigne, Jean-Olivier ULg; Demoulin, J. C.; Pierard, Gérald ULg et al

in American Journal of Dermatopathology (1997), 19(6), 602-5

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a ... [more ▼]

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a left atrial thrombus and was complicated by cerebral embolization. Simultaneously, skin nodules manifested on both forearms. Histologic examination revealed typical aspects of early evolving botryomycosis with massive infiltration of the dermis and hypodermis by necrotic granulomas framed by grains of Gram-positive coccoid forms. Bacteria were decorated by a nonspecific polyclonal antibody to Mycobacterium bovis. [less ▲]

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See detailAcute Functional Iron Deficiency in Obese Subjects During a Very-Low-Energy All-Protein Diet
Beguin, Yves ULg; Grek, Vincent; Weber, Georges ULg et al

in American Journal of Clinical Nutrition (1997), 66(1), 75-9

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 ... [more ▼]

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 g protein after a 1-wk period during which total daily energy intake was progressively reduced to 1.26 MJ. Serum iron fell sharply by approximately equal to 50% (P < 0.0001), and despite a small decrease in total-iron-binding capacity, transferrin saturation decreased from 30 +/- 11% to 18 +/- 5% (P < 0.0001). Serum ferritin did not change significantly but serum soluble transferrin receptor (sTfR), an indicator of iron deficiency, increased progressively from 4630 +/- 1110 to 6070 +/- 1390 micrograms/L (P < 0.0001). Changes in sTfR correlated inversely with prior changes in serum iron. Changes in iron metabolism did not translate into changes in erythropoiesis or red cell indexes, but the white blood cell count decreased from 7.3 +/- 1.6 to 6.2 +/- 1.9 x 10(9)/L (P < 0.002). There was no evidence of deficiency for the other trace elements and minerals tested. Daily supplementation with 200 mg Fe in 18 other subjects only partially corrected these observations despite some increase in iron stores. These results indicate that during a 2-wk VLED serum iron is significantly depressed, inducing functional tissue iron deficiency too short in duration to produce alterations in red blood cell indexes. These changes are not mediated by absolute iron deficiency, inflammation, or protein malnutrition but could be related to alterations in the iron storage and release behavior of the reticuloendothelial cell during energy deprivation alone. [less ▲]

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See detailInfluence of whole milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats
Hornick, Jean-Luc ULg; Clinquart, Antoine ULg; Van Eenaeme, Christian ULg et al

in Livestock Production Science (1997), 48

Influence of milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats. The use of milk as component ... [more ▼]

Influence of milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats. The use of milk as component of a fattening diet for bulls was studied in an experiment carried-out over 2 years with Belgian Blue bulls. The animals weighed 305 kg at the beginning of the experiment. In all, 15 bulls were given a control concentrate fattening diet (control group, CG), while 11 others were fed concentrate plus 6.5 to 11 1 whole milk per day according to weight or age (milk group, MG). The fattening period lasted for 174 and 181 d respectively in groups CG and MG. The MG-group had a higher killing-out percentage (P < 0.01) and the meat was characterized by a lower b* value and a lower dry matter content (P < 0.1). Whole milk in the diet increased the proportion of shorter chain and saturated fatty acids in fat (P < 0.001) and reduced the proportion of mono- and polyunsaturated acids (P < 0.05; P < 0.1). The extent of the changes were larger in subcutaneous and intermuscular fats than in intramuscular fat. [less ▲]

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See detailAutoregulation of endogenous glucose production in man.
Tappy, L.; Tounian, P.; Paquot, Nicolas ULg

in Biochemical Society Transactions (1997), 25(1), 11-3

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See detailLuteinizing hormone increases the abundance of various transcripts, independently of the androgens, in the rat prostate.
Reiter, E.; Poncin, Joseph ULg; Hennuy, Benoît ULg et al

in Biochemical and Biophysical Research Communications (1997), 233(1), 108-12

Differential display analysis was carried out to find, in the rat prostate, genes that could be regulated by Luteinizing Hormone (LH), independently of the androgens. Hypophysectomized and castrated adult ... [more ▼]

Differential display analysis was carried out to find, in the rat prostate, genes that could be regulated by Luteinizing Hormone (LH), independently of the androgens. Hypophysectomized and castrated adult rats were treated with either LH, testosterone or saline. Regulated discrete bands have been eluted and reamplified. After Northern blotting, the levels of mRNA corresponding to 8 PCR fragments were significantly increased by LH treatment. None of these inserts were found to be induced by testosterone. One insert was subcloned, sequenced and identified as the ribosomial protein S 23. A competitive RT-PCR assay was carried out on the full length S 23 cDNA and confirmed that its mRNA levels were stimulated by LH but not by testosterone. These results strongly suggest that the LH membrane receptor, previously shown to be expressed in the rat prostate, has a physiological significance in this organ. Moreover, it appears that the effect of LH on the rat prostate are independent of the androgens. [less ▲]

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See detailA novel seizure-induced synaptotagmin gene identified by differential display.
Babity, J. M.; Armstrong, J. N.; Plumier, Jean-Christophe ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94(6), 2638-41

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of ... [more ▼]

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of motor convulsions and the degeneration of neurons in the hippocampus and piriform cortex. Differential display PCR was used to identify mRNAs that are differentially expressed between degenerating and nondegenerating tissues in the brain after kainic acid-induced seizure activity. A novel cDNA fragment expressed in the degenerating hippocampus and piriform cortex, but not in the nondegenerating parietal cortex, was identified, cloned, and sequenced. This novel cDNA fragment identified a new member of the synaptotagmin gene family that is rapidly and transiently induced in response to seizure activity. Differential expression of this synaptotagmin gene, syt X, was confirmed by Northern blot analysis and in situ hybridization. This novel, inducible synaptotagmin gene may provide a direct link between seizure-induced neuronal gene expression and subsequent modulation of synaptic structure and function. [less ▲]

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See detailHooliganisme: la délinquance des stades de football
Comeron, Manuel ULg

in Déviance et Société (1997), 21(1), 97-113

Analyse de la violence des supporters: individuelle, groupale, foule et sociétale.

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See detailMeasurements of the ground state ionization energy and wavelengths for the 1snp1P1 - 1s2 1S0(n=4-10) lines of O VII
Bartnik, A.; Biémont, Emile ULg; Dyakin, V. M. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1997), 30

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See detailScintigraphic visualization of intrathecal liposome biodistribution.
Umbrain, V; D'Haese, J; Alafandy, M et al

in Acta Anaesthesiologica Scandinavica (1997), 41(1 Pt 1), 25-34

BACKGROUND: Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers ... [more ▼]

BACKGROUND: Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers. Therefore, we observed the biodistribution of liposomes after intrathecal injection in rats by scintigraphic imaging during 24 h. METHODS: We administered 99mTc-labeled multilamellar (MLV) and small unilamellar vesicles (SUV) of defined size and volume dispersities into the cerebrospinal fluid at the lumbar level. Those vesicles were free of contamination by radiolabeled colloids as visualized by light and electron microscopy and of neurotoxic products from phosphatidylcholine hydrolysis and peroxidation, both during the preparation process and after 24 h incubation in cerebrospinal fluid at 37 degrees C in vitro. RESULTS: SUV immediately diffused from the lumbar site of injection to the head and were cleared between 1 and 24 h after injection. MLV were cleared more slowly from the spinal space and appeared in the head region 1 h after injection where they accumulated up to 24 h. These differences were explained in terms of vesicle sizes and volumes. SUV with 0.05 micron diameters were rapidly absorbed into the blood through the arachnoid granulations. In contrast, particles larger than the upper size limit of the arachnoid granulations permeability (+/- 8 microns) could accumulate in the head with a slow elimination rate. CONCLUSION: This difference in clearance from the intrathecal space outlines the importance of defining the size of the liposomes, the distribution of a tracer or a drug inside the liposomal preparation, the chemical stability and the absence of toxic degradation products of liposome formulations before clinical use. [less ▲]

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See detailCharacterization of Clostridium perfringens isolates from goats.
Phukan, A.; Dutta, G.-N.; Daube, Georges ULg et al

in Indian Veterinary Journal (The) (1997), 74

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See detailInterobserver agreement on MNA nutritional scale of hospitalized elderly patients
Gazzotti, C.; Pepinster, A.; Petermans, Jean ULg et al

in Journal of Nutrition, Health & Aging (The) (1997), 1

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See detailReprésentation de l'espace ouvert dans un système d'information de projet urbain
Dupagne, A.; Teller, Jacques ULg

in Ingénierie des Systèmes d'Information (1997), 5(2), 219-240

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See detailCombined Effect of Web 2086 (Paf Antagonist) and Ketoprofen (Nsaid) on Paf-Induced Ex Vivo Platelet Aggregation in Bovine
Bastos da Silva, Miriam; Herion, Francine ULg; Raskinet, Renée ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1997), 44(2), 65-71

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich ... [more ▼]

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich plasma (PRP). WEB 2086 was infused intravenously over 1 min followed immediately by ketoprofen administration over 1 s (both drugs = 3 mg/kg), in a group of six healthy male Friesian calves. Depending on the PAF concentration, a reversible (10(-8)-10(-9) mol/l) and irreversible (10(-5)-10(-7) mol/l) platelet aggregation was observed. The reversible aggregation was completely blocked by pretreatment of the animal with WEB 2086 and ketoprofen. The inhibitory effects observed during the irreversible aggregation were 47.22%, 54.00% and 88.00% at 10(-5), 10(-6) and 10(-7) mol/l PAF, respectively. Moreover, the aggregation obtained in these condition became reversible. Maximal inhibitory effect of WEB 2086 and ketoprofen on PAF-induced platelet aggregation in calves was observed within 30 min after administration of both drugs. This inhibition persisted even after 24 h and was significantly different from control with P < 0.05. The combined effect of both drugs exceeded the sum of the individual effects (synergism). It was concluded that WEB 2086 and ketoprofen very effectively blocked PAF-induced bovine platelet aggregation in platelet-rich plasma. The study also suggested a synergism between both substances. [less ▲]

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See detailEffect of diet and bST on mRNA for IGF-I binding proteins (BP)-2 and -3 in dairy cattle
Sharma, B. K.; Vandehaar, M. J.; Tucker, H. A. et al

in Journal of Dairy Science (1997), 80(suppl 1), 176

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