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See detailRobust Validation of Measurements on jet Engines
Dewallef, Pierre ULg; Léonard, Olivier ULg

in European Journal of Mechanical and Environmental Engineering (2001), 46(4), 237-242

Nowadays, most of turbine engine tests are processed using an open loop, i.e. the measurements are verified and treated a posteriori, sometimes weeks or months after the end of the test. The scope of the ... [more ▼]

Nowadays, most of turbine engine tests are processed using an open loop, i.e. the measurements are verified and treated a posteriori, sometimes weeks or months after the end of the test. The scope of the present project is to develop a new methodology which enables real time detection of faulty measurements and the suppression of the source of these faults during the test. This implies the development of a method which is sufficiently robust to cope with a lot of faulty data (up to 20 to 30 % of the measurements). Most of the existing methods make use of a least square approach so that a set of parameters is sought which minimizes the RMS error between the measurements and the values provided by a numerical model of the installation. This type of approach is efficient in finding whether a set of measurements is valid but cannot locate the fault(s). In this paper an alternative is proposed based on a distribution of the measurement noise introduced by Huber. This so-called robust validation method has been tested on a single spool, single flow and variable geometry nozzle turbojet. Both the least square and Huber's function approaches have been tested and compared in terms of efficiency. The robust estimator based on Huber's error function has shown to be much more powerful for both finding an invalid set of measurements and locating the faulty measurements. [less ▲]

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See detailDissemination of Catabolic Plasmids among Desiccation-Tolerant Bacteria in Soil Microcosms
Weekers, Frederic; Rodriguez, Christian; Jacques, Philippe ULg et al

in Applied Biochemistry and Biotechnology (2001), 91-93(Spring), 219-32

The dissemination of catabolic plasmids was compared to bioaugmentation by strain inoculation in microcosm experiments. When Rhodococcus erythropolis strain T902, bearing a plasmid with trichloroethene ... [more ▼]

The dissemination of catabolic plasmids was compared to bioaugmentation by strain inoculation in microcosm experiments. When Rhodococcus erythropolis strain T902, bearing a plasmid with trichloroethene and isopropylbenzene degradation pathways, was used as the inoculum, no transconjugant was isolated but the strain remained in the soil. This plasmid had a narrow host range. Pseudomonas putida strain C8S3 was used as the inoculum in a second approach. It bore a broad host range conjugative plasmid harboring a natural transposon, RP4::Tn4371, responsible for biphenyl and 4-chlorobiphenyl degradation pathways. The inoculating population slowly decreased from its original level (10(6) colony-forming units [CFU]/g of dry soil) to approx 3 x 10(2) CFU/g of dry soil after 3 wk. Transconjugant populations degrading biphenyl appeared in constant humidity soil (up to 2 x 10(3) CFU/g) and desiccating soil (up to 10(4) CFU/g). The feasibility of plasmid dissemination as a bioaugmentation technique was demonstrated in desiccating soils. The ecologic significance of desiccation in bioaugmentation was demonstrated: it upset the microbial ecology and the development of transconjugants. [less ▲]

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See detailEtude clinique du mois. Protection secondaire de l'accident vasculaire cerebral par le perindopril: l'etude PROGRESS.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(11), 792-5

PROGRESS ("Perindopril pROtection aGainst REcurrent Stroke Study") demonstrated that blood-pressure lowering treatment with perindopril, an angiotensin converting enzyme inhibitor (combined with the ... [more ▼]

PROGRESS ("Perindopril pROtection aGainst REcurrent Stroke Study") demonstrated that blood-pressure lowering treatment with perindopril, an angiotensin converting enzyme inhibitor (combined with the diuretic agent indapamide when necessary), reduces the risk of stroke by 28% (95% CI: 17-38, p < 0.0001) among patients with a history of stroke or transient ischaemic attack. This protective effect was observed among both hypertensive and non-hypertensive individuals. It was more marked in the patients receiving combined perindopril + indapamide treatment (-43%; 95% CI 30-54) who were those who showed the greatest reduction in arterial blood pressure (-12/5 mm Hg). According to these observations, the authors concluded that treatment with these two agents should now be considered routinely for patients with a history of stroke or transient ischaemic attack, irrespective of their blood pressure. [less ▲]

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See detailA magnetic and conversion electron Mossbauer spectral study of amorphous Dy20Fe80-yCoy thin films
Fleury-Frenette, Karl ULg; Delwiche, Jacques ULg; Grandjean, Fernande ULg et al

in IEEE Transactions on Magnetics (2001), 37(4), 2311-2314

Amorphous thin films of Dy20Fe80-yCoy, with 0 < y < 20 and of ca. 40 nm thickness, have been prepared by sputtering on polyimide substrates. The 295 K conversion electron Mossbauer spectra (CEMS) of these ... [more ▼]

Amorphous thin films of Dy20Fe80-yCoy, with 0 < y < 20 and of ca. 40 nm thickness, have been prepared by sputtering on polyimide substrates. The 295 K conversion electron Mossbauer spectra (CEMS) of these films consist of broadened sextets which have been analyzed with a distribution of hyperfine fields in which the iron moments are oriented perpendicular to the plane of the film, an orientation which is in agreement with the perpendicular magnetic anisotropy observed herein at 295 K by vibrating sample magnetrometry. The average hyperfine field and isomer shift increase linearly with increasing Co content. Both increases arise from an increase in the electron occupation of the 3d states as the cobalt content increases. [less ▲]

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See detailYoung Investigators Workshop participants (P.A Coucke) and N. Coleman : Radiation Research program, Radiation Oncology Sciences Program, National Cancer Institue, Nih, August 1-2, 2000
Coucke, Philippe ULg

in International Journal of Radiation, Oncology, Biology, Physics (2001), 49(5), 1505-1516

INTRODUCTION The one-and-a-half day Young Investigators Workshop was held in the Holiday Inn, Bethesda, August 1–2, 2000. Using the SCAROP mailing list and recommendations from department chiefs ... [more ▼]

INTRODUCTION The one-and-a-half day Young Investigators Workshop was held in the Holiday Inn, Bethesda, August 1–2, 2000. Using the SCAROP mailing list and recommendations from department chiefs, approximately 55 “early-career” physicianscientists were invited to attend the workshop. Table 1 includes the participants. The goals of the meeting were: c To bring together radiation oncology physician-scientists who were in the early part of their career to discuss research ideas and opportunities as well as potential barriers to progress for the field and for young-investigator careers. c To help develop camaraderie among and a critical-mass of a new generation of physician-scientists with interests ranging from technology development, to basic and translational research, to outcomes research and analysis. c To help the young investigators gain familiarity with the NIH grant programs. c To prepare a “white paper” with their vision and ideas for potential opportunities for the future. If possible, a shortand long-term agenda were to be proposed. The first morning included presentations from a variety of NCI programs. Three breakout sessions were held in the afternoon. Breakout Group Reports were discussed by the entire group the following morning. A fourth discussion topic on “Barriers To a Successful Research Career” was conducted by the entire group. Drafts of this entire Workshop Report were circulated to the participants. The final document represents the efforts of the entire Young Investigators Workshop and provides the perspective from the point of view of the investigators who have many years to invest in the future of radiation oncology. The Radiation Research Program (RRP) is grateful to all the participants for a lively workshop and to the session co-chairs for the timely preparation of this report. [less ▲]

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See detailPour une télématique de service public
Rondeaux, Giseline ULg; Schoenaers, Frédéric ULg

in Revue de Gestion (2001), (printemps),

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See detailDistinct carbohydrate recognition domains of an invertebrate defense molecule recognize Gram-negative and Gram-positive bacteria.
Bilej, M.; De Baetselier, P.; Van Dijck, E. et al

in Journal of Biological Chemistry (2001), 276(49), 45840-7

Coelomic fluid of Eisenia foetida earthworms (Oligochaeta, Annelida) contains a 42-kDa defense molecule named CCF for coelomic cytolytic factor. By binding microbial antigens, namely the O-antigen of ... [more ▼]

Coelomic fluid of Eisenia foetida earthworms (Oligochaeta, Annelida) contains a 42-kDa defense molecule named CCF for coelomic cytolytic factor. By binding microbial antigens, namely the O-antigen of lipopolysaccharide (LPS), beta-1,3-glucans, or N,N'-diacetylchitobiose present, respectively, on Gram-negative bacteria or yeast cell walls, CCF triggers the prophenoloxidase activating pathway. We report that CCF recognizes lysozyme-predigested Gram-positive bacteria or the peptidoglycan constituent muramyl dipeptide as well as muramic acid. To identify the pattern recognition domains of CCF, deletion mutants were tested for their ability to reconstitute the prophenoloxidase cascade in E. foetida coelomic fluid depleted of endogenous CCF in the presence of LPS, beta-1,3-glucans, N,N'-diacetylchitobiose, and muramic acid. In addition, affinity chromatography of CCF peptides was performed on immobilized beta-1,3-glucans or N,N'-diacetylchitobiose. We found that the broad specificity of CCF for pathogen-associated molecular patterns results from the presence of two distinct pattern recognition domains. One domain, which shows homology with the polysaccharide and glucanase motifs of beta-1,3-glucanases and invertebrate defense molecules located in the central part of the CCF polypeptide chain, interacts with LPS and beta-1,3-glucans. The C-terminal tryptophan-rich domain mediates interactions of CCF with N,N'-diacetylchitobiose and muramic acid. These data provide evidence for the presence of spatially distinct carbohydrate recognition domains within this invertebrate defense molecule. [less ▲]

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See detailOptimisation and Use of Tandem-in-Time Mass Spectrometry in Comparison with Immunoassay and Hrgc/Hrms for Pcdd/F Screening
Focant, Jean-François ULg; Eppe, Gauthier ULg; De Pauw, Edwin ULg

in Chemosphere (2001), 43(4-7, May-Jun), 417-24

Rapid screening of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans using quadrupole ion storage tandem-in-time mass spectrometry (QISTMS) conjointly with polyclonal antibody ... [more ▼]

Rapid screening of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans using quadrupole ion storage tandem-in-time mass spectrometry (QISTMS) conjointly with polyclonal antibody immunoassay has been considered. The optimisation of the fragmentation of the parent ion in the trap has been completed. The analysis of fly ashes from a municipal waste incinerator contaminated at different levels has then been realised. Results obtained using QISTMS, HRMS and immunoassay are compared. [less ▲]

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See detailKöln und das 'Oberländische' im Spätmittelalter
Möller, Robert ULg

in Rheinische Vierteljahrsblätter (2001), 65

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See detailAn 'other-race' effect in age estimation from faces
Dehon, Hedwige ULg; Brédart, Serge ULg

in Perception (2001), 30(9), 1107-1113

Previous studies have shown that, in person-recognition tasks, people performance better for gaces belonging to their own race than for those belonging to another race. Recently, however, this 'other-race ... [more ▼]

Previous studies have shown that, in person-recognition tasks, people performance better for gaces belonging to their own race than for those belonging to another race. Recently, however, this 'other-race' effect has also been found in a sex-discrimination task (O'Toole et al, 1996, Perception 25, 669-676). In the present study, we investigated wheter this finding extends to age perception. Caucasian and African participants were asked to estimate the age of Caucasian and African faces. The main result of this experiment was a significant 'race of subject' x 'race of face' interaction showing that Caucasian participants performed better at evaluating Caucasian faces than African faces. However, African participants performed equally with both type of faces. This result is explained by the Africans' time of residence in Belgium. This implication of this 'older-race' effect for age estimation is discussed with respect to eyewitness reports. [less ▲]

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See detailL'exigence de motivation des décisions ordonnant un repérage ou une écoute téléphonique
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2001)

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See detailThe ornithine decarboxylase gene is essential for cell survival during early murine development
Pendeville-Samain, Hélène ULg; Carpino, Nick; Marine, Jean-Christophe et al

in Molecular & Cellular Biology (2001), 21(19), 6549-58

Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse ... [more ▼]

Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse biological processes, including cell growth, differentiation, transformation, and apoptosis. To explore the physiological function of ODC in mammalian development, we generated mice harboring a disrupted ODC gene. ODC-heterozygous mice were viable, normal, and fertile. Although zygotic ODC is expressed throughout the embryo prior to implantation, loss of ODC did not block normal development to the blastocyst stage. Embryonic day E3.5 ODC-deficient embryos were capable of uterine implantation and induced maternal decidualization yet failed to develop substantially thereafter. Surprisingly, analysis of ODC-deficient blastocysts suggests that loss of ODC does not affect cell growth per se but rather is required for survival of the pluripotent cells of the inner cell mass. Therefore, ODC plays an essential role in murine development, and proper homeostasis of polyamine pools appears to be required for cell survival prior to gastrulation. [less ▲]

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See detailA thoughtful approach to brain tumours
Deprez, Manuel ULg

in Lancet (2001), Vol 358

Brain Tumours is a serious book, more than 1000 pages long, with 50 chapters, and the efforts of nearly 100 contributors. The editors begin by reminding us that surgery has always had a central role in ... [more ▼]

Brain Tumours is a serious book, more than 1000 pages long, with 50 chapters, and the efforts of nearly 100 contributors. The editors begin by reminding us that surgery has always had a central role in the management of brain tumours. However, surgical resection is often incomplete because of diffuse infiltration and the anatomical limits imposed by the surgical approach, or by proximity to the eloquent cortex. Incomplete resection undoubtedly contributes to tumour progression or recurrence, and the means to solve this dilemma lie in the collaborative effort of various medical and scientific disciplines. [less ▲]

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See detailEvaluation of ruthenium-based complexes for the controlled radical polymerization of vinyl monomers
Simal, François; Jan, Dominique; Delaude, Lionel ULg et al

in Canadian Journal of Chemistry (2001), 79(5-6), 529-535

New complexes of the type RuCl2(p-cymene)L where the ligand L is either a phosphine or a stable triazolinylidene carbene have been tested and compared to the Grubbs' benzylidene complex RuCl2(=CHPh)(PCy3 ... [more ▼]

New complexes of the type RuCl2(p-cymene)L where the ligand L is either a phosphine or a stable triazolinylidene carbene have been tested and compared to the Grubbs' benzylidene complex RuCl2(=CHPh)(PCy3)(2) as catalyst precursors for the controlled atom transfer radical polymerization (ATRP) of methyl methacrylate and of various para-substituted styrenes. Kinetic data and Hammett rho constants are reported, as well as the X-ray structure of the ortho-metallated triazolinylidene-ruthenium(II) complex RuCl(p-cymene)[1,2-phenylene[3,4-diphenyl-1H-1,2,4-triazol-1-yl-5(4H)-yl idene]]. [less ▲]

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See detailMetabolic and Structural Abnormalities in Dogs with Early Left Ventricular Dysfunction Induced by Incessant Tachycardia
Mc Entee, Kathleen ULg; Flandre, Thierry; Doizé, Cécile ULg et al

in American Journal of Veterinary Research (2001), 62(6), 889-94

OBJECTIVE: To assess morphologic and metabolic abnormalities in dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP). ANIMALS: 7 Beagles. PROCEDURE: Plasma ... [more ▼]

OBJECTIVE: To assess morphologic and metabolic abnormalities in dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP). ANIMALS: 7 Beagles. PROCEDURE: Plasma carnitine concentrations were measured before and after development of ELVD induced by RRVP. At the same times, transvenous endomyocardial biopsy was performed, and specimens were submitted for determination of myocardial carnitine concentrations and histologic, morphometric, and ultrastructural examination. RESULTS: In 4 dogs in which baseline plasma total carnitine concentration was normal, RRVP induced a decrease in myocardial total and free carnitine concentrations and an increase in myocardial esterified carnitine concentration. In 3 dogs in which baseline plasma total carnitine concentration was low, plasma and myocardial carnitine concentrations were unchanged after pacing. Structural changes associated with pacing included perinuclear vacuolization in 3 dogs. Morphometric analyses indicated there was a decrease in myofiber cross-sectional diameter and area following pacing. Electron microscopy revealed changes in myofibrils and mitochondria following pacing. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that moderate to severe alterations in myocyte cytoarchitecture are present in dogs with ELVD induced by RRVP and that in dogs with normal plasma carnitine concentrations, myocardial carnitine deficiency may be a biochemical marker of ELVD. Results also indicated that transvenous endomyocardial biopsy can be used to evaluate biochemical and structural myocardial changes in dogs with cardiac disease. [less ▲]

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See detailHuman viral infections derived from food
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Point Vétérinaire (2001), 32(218, AUG-SEP),

Several viruses may be transmitted to humans via food including hepatitis A and E virus (VHA and VHE), Norwalk type calicivirus, rotavirus and astrovirus. Enterovirus and enteric adenovirus may also be ... [more ▼]

Several viruses may be transmitted to humans via food including hepatitis A and E virus (VHA and VHE), Norwalk type calicivirus, rotavirus and astrovirus. Enterovirus and enteric adenovirus may also be transmitted. Sick people or healthy carriers excrete these viruses in their stools. Shellfish and water are the most frequently contaminated foodstuffs. Another route of infection is during handling of food. Detection of these viruses in food is complex for several reasons: the interaction of virus and food makes viral concentration and purification difficult, in vitro culture of these viruses is difficult if not impossible, and the quantity of virus present in the sample is low. Molecular technology (PCR) is the most suitable method of detection. Another method is to choose an indicator of viral faecal contamination. [less ▲]

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See detailThe behavioral effects of acute and chronic JL 13, a putative antipsychotic, in Cebus non-human primates
Casey, Daniel; Bruhwyler, Jacques; Delarge, Jacques et al

in Psychopharmacology (2001), 157

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See detailProtein adsorption on preadsorbed polyampholytic monolayers
Mahltig, Boris; Werner, Carsten; Müller, Martin et al

in Journal of Biomaterials Science. Polymer Edition (2001), 12(9), 995-1010

The adsorption behaviour of five different globular proteins on pure silicon substrates and on preadsorbed polyampholytic monolayers has been investigated as a function of protein concentration. The ... [more ▼]

The adsorption behaviour of five different globular proteins on pure silicon substrates and on preadsorbed polyampholytic monolayers has been investigated as a function of protein concentration. The prelayers were prepared by adsorption of the ampholytic diblock copolymer poly(methacrylic acid)-block-poly ((dimethylamino)ethyl methacrylate) (PMAA-b-PDMAEMA). This polyampholyte adsorbs in densely packed micelles directly from aqueous solution. Ellipsometry was used to determine the amount of adsorbed polyampholyte and protein. While ATR-IR spectroscopy gives information about the adsorption and desorption behaviour of the preadsorbed polyampholytic layer, the lateral structures of the dried films were investigated by scanning force microscopy (SFM). The amount of protein adsorbed was found to be strongly influenced by the preadsorbed polyampholyte compared to the adsorption on the pure silicon substrates. No displacement of the polyampholyte by the proteins was detected. In most cases the protein adsorption was reduced by the preadsorbed polyampholytic layer. The observed trends are explained by the change in electrostatic and hydrophilic characteristics of the substrates. Furthermore, the entropy of adsorption has to be taken into account. [less ▲]

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See detailIntensive and Prolonged Health Promotion Strategy May Increase Awareness of Osteoporosis among Postmenopausal Women
Tellier, V.; De Maeseneer, J.; De Prins, L. et al

in Osteoporosis International (2001), 12(2), 131-5

The aim of the study was to measure the results of a 15-year health promotion strategy towards osteoporosis, in an urban community of subjects over 45 years old, in terms of osteoporosis awareness and ... [more ▼]

The aim of the study was to measure the results of a 15-year health promotion strategy towards osteoporosis, in an urban community of subjects over 45 years old, in terms of osteoporosis awareness and handling. To this end an ancillary study to a large survey of the Belgian population's self-perceived health status was carried out. A rectangular sample of 4800 individuals over 45 years old was randomly selected in two Belgian cities, among the affiliates of the two main health insurance providers. One of the cities (Liege) had been, since the early 1980s, the target of a constant health promotion strategy, directed to both the medical community and the general population, aimed at increasing osteoporosis awareness in women after the menopause. During the same period, no particular steps were taken in the other city (Aalst) to increase osteoporosis awareness in the community. In our study, the participants were asked to spontaneously report any chronic, serious and/or severe disorders that they had been suffering from, for at least 6 months, during the previous 12 months. They also provided a list of drugs they were taking at the time of the survey. Osteoporosis was reported to be a disease affecting 1.5% of men in Aalst and 1.3% of men in Liege (p = 0.61). For women, osteoporosis was reported to be present in 4.8% in Aalst and 10.8% in Liege (p<0.001). Self-reporting of osteoporosis prevalence in Liege was statistically significantly higher in women aged 45-64 years, 65-74 years or over 75 years (p<0.001). Obesity, alcohol consumption or physical activity were equally distributed between women from Liege and Aalst. Prescription drugs used for osteoporosis had been delivered to a similar proportion of men in Aalst and Liege. In women, a statistically significant difference in these prescription drugs was observed between Liege and Aalst, both for the overall population (p<0.001) and in each of the age classes (p<0.001 for 45-64 years and 65-74 years; p<0.009 for over 75 years). A continuous long-term health promotion strategy, directed toward both physicians and the general population, thus appears to increase awareness about osteoporosis in women over 45 years and/or in the medical community. This is reflected by an increase in self-reported prevalence of osteoporosis and in the prescription of drugs aimed at prevention and treatment of this disorder. Whether these observations reflect an appropriate diagnosis and a proper handling of the disease remains to be evaluated by objective diagnostic tools such as bone densitometry and by an evaluation of the effectiveness of prescription practices in postmenopausal women. [less ▲]

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See detailStability of strange quark matter in an effective chiral model with scale anomaly
Jaminon, Martine ULg; Van den Bossche, Bruno

in Nuclear Physics A (2001), 686

Stability of strange quark matter is investigated within a chiral model which implements the scale anomaly of QCD. As far as quark confinement is mimicked by a large value of the u-quark mass, the model ... [more ▼]

Stability of strange quark matter is investigated within a chiral model which implements the scale anomaly of QCD. As far as quark confinement is mimicked by a large value of the u-quark mass, the model behaves in the chiral limit as a MIT bag model: it yields a stable system composed of quarks surrounded by the vacuum. As soon as finite current quark masses are taken into account, stability is however lost. [less ▲]

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See detailExtended analysis of the spectrum of triply-ionozed Ytterbium (Yb IV) and transition probabilities
Wyart, J.-F.; Tchang-Brillet, W. U. L.; Spector, N. et al

in Physica Scripta (2001), 63

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See detailNouvelles approches thérapeutiques puor l'hypernéphrome métastasique
Sylvestre, Rose-Marie; Jerusalem, Guy ULg; Sautois, Brieuc ULg et al

in Médecine et Hygiène (2001), 59

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See detailUne innovation dans la chirurgie hellénistique: l'opération de la cataracte
Marganne, Marie-Hélène ULg

in Medizinhistorisches Journal (2001), 36(1), 23-33

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See detailVerifìcarea unei structuri metalice pentru depozitare paletizata la actinuea focului
Zaharia, R.; Franssen, Jean-Marc ULg

in Zilele Academice Timisorene Editia VII - Buletinul Stiintific al Universitatii Politehnica din Timisoara (2001), 46(60), 288-298

The paper presents a fire design study case for a high-rise storage rack supporting building. Standardised ISO and natural fire models were considered for the fire action. The advanced numerical analysis ... [more ▼]

The paper presents a fire design study case for a high-rise storage rack supporting building. Standardised ISO and natural fire models were considered for the fire action. The advanced numerical analysis was carried out by means of SAFIR program, a FEM software specialised for the mechanical analysis of structures under elevated temperatures. [less ▲]

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See detailImplication de la neurohypophyse dans le stress psychique
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Legros, Jean-Jacques ULg

in Encéphale (L') (2001), 27(3, May-Jun), 245-59

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various ... [more ▼]

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various psychiatric diseases such an anorexia nervosa, bipolar disorder, schizophrenia and obsessive-compulsive disorder. AVP and OT are secreted into the hypophyseal portal circulation by neurons which project from the paraventricular nucleus to the external zone of the median eminence. AVP and OT-containing neurons in the suprachiasmatic and paraventricular nuclei project to limbic areas, including the hippocampus, the subiculum, the ventral nucleus of the amygdala and the nucleus of the diagonal band. Specific AVP receptors which are pharmacologically different from the pressor and antidiuretic AVP receptors have been found in the anterior pituitary. OT receptors have been identified in a variety of forebrain sites. The neurohypophyseal secretion is regulated by the cholinergic muscarinic, histaminergic and beta-adrenergic systems. Stress alters the secretion of one or more of the hypothalamic factors which interact at the pituitary to increase the secretion of ACTH. AVP and OT have been shown to modulate the effect of Corticotropin-Releasing Factor (CRF) on ACTH secretion and appear to play a key role in mediating the ACTH response to stress. Although AVP is a relatively weak secretagogue for ACTH, it markedly potentiates the activity of CRF both in vitro and in vivo. The role of OT is more complex. In vitro, OT stimulates ACTH release at high doses whereas in human it inhibits ACTH secretion at low doses. The type of stressor appear to determine the relative importance of these secretatogues in ACTH response. Several recent studies indicate that psychological stressors display a similar degree of variety of secretagogue release patterns as was found earlier for physical stressors. A bewildering array of technique produces a bewildering array of conclusions. In rats, OT may be an important secretagogue during a novel stimulus, whereas the role for AVP is less clear. Indeed two studies out of ten suggest a stimulating role for AVP. In response to frustration and submission, OT and AVP are secreted. Regarding social isolation, results are difficult to interpret and the role of AVP could be species-dependent. In contrast plasma OT levels do not change. After restraint, ACTH release is primarily mediated by the active increase of OT and AVP does not appear to play a role. When restraint is associated with moderate levels of physical components and during immobilisation, all two secretagogs are involved in the ACTH response. With fear, ACTH response appears to be driven by OT. In humans, one study indicates that high emotionality women increase plasma OT in response to uncontrollable noise. Various neuroendocrine dysregulations have been observed in psychiatric disease. Either an increase or a decrease of the hypothalamic-pituitary-adrenal (HPA) function have been described in several illnesses. Effects of OT appear to be reciprocal to the effects of AVP. OT has been called the "amnestic" neuropeptide due to its capacity to attenuate memory consolidation and retrieval. AVP exhibits a central activating action on mood, memory and selective attention. Underweight patients with anorexia nervosa have abnormally high levels of centrally directed AVP and reduced OT levels. These modifications could enhance the retention of cognitive distortions of aversive consequences of eating. Patients with bipolar disorder show a biphasic secretion of AVP. Depressive episodes are associated with decreased vasopressinergic activity whereas manic episodes involve an increased release. AVP might be responsible for an increased catecholamine activity. In addition, lithium could act as an antagonist to AVP. In schizophrenic patients, studies using the apomorphine stimulation suggest increased oxytoninergic and decreased vasopressinergic functions. These findings are consistent with the beneficial role of AVP on schizophrenic symptoms noted in several trials. The increased OT could be responsible for "positive" symptomatology such as delusions and hallucinations. Obsessive compulsive disorder (OCD) includes a range of cognitive and behavioral disturbances that could be influenced by OT. In animals, several studies have emphasized the role of AVP in promoting repetitive grooming behaviors and maintaining conditioned response to aversive stimuli. In OCD patients, one study have reported that AVP/OT ratio was negatively correlated with symptom severity. However, an independent report found similar AVP concentrations in OC patients without a personal or family history of tic disorder and in normal subjects. Whether these modifications are only a consequence of the central disturbances or whether those peptides could participate in the pathogenesis of these affections remains to be elucidated. [less ▲]

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See detailIncreased Camp Levels and Protein Kinase (Pka) Type I Activation in Cd4+ T Cells and B Cells Contribute to Retrovirus-Induced Immunodeficiency of Mice (Maids): A Useful in Vivo Model for Drug Testing
Rahmouni, Souad ULg; Aandahl, Einar Martin; Trebak, Mohamed et al

in FASEB Journal (2001), 15(8), 1466-1468

Murine AIDS (MAIDS) is characterized by a lymphoproliferative disease and a profound anergy, which involves mostly CD4(+) T cells. To better define the mechanisms responsible for anergy, we measured cAMP ... [more ▼]

Murine AIDS (MAIDS) is characterized by a lymphoproliferative disease and a profound anergy, which involves mostly CD4(+) T cells. To better define the mechanisms responsible for anergy, we measured cAMP concentrations in the different lymphocyte subsets of the infected mice. CD4(+) T cells and B cells displayed a dramatic 10- to 30-fold increase of cAMP. cAMP was also significantly increased in CD8(+) T cells, although to a far lesser extent. The unusual CD4(+) CD90(-) T cells, typical of MAIDS, were characterized by a much higher cAMP level than their CD90(+) counterparts. T cells of the infected mice were much more sensitive to inhibition by the cAMP analogue 8-CPT-cAMP, which confirmed increased in vivo exposure to cAMP. In accordance with the increased cAMP levels, PKA type I was constitutively activated and its C subunit was translocated to the nucleus. Finally, the profound T-cell anergy associated with MAIDS could be reversed by treating T cells with a PKA type I-selective antagonist ex vivo. MAIDS could constitute a suitable model for the study of new pharmacological agents aimed at reversing the immunosuppressive effects of cAMP previously shown to be involved in several pathological states, including HIV infection and common variable immunodeficiency. [less ▲]

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See detailKinetics of light emission and oxygen consumption by bioluminescent bacteria.
Bourgeois, J. J.; Sluse, Francis ULg; Baguet, F. et al

in Journal of Bioenergetics & Biomembranes (2001), 33

Oxygen plays a key role in bacterial bioluminescence. The simultaneous and continuous kinetics of oxygen consumption and light emission during a complete exhaustion of the exogenous oxygen present in a ... [more ▼]

Oxygen plays a key role in bacterial bioluminescence. The simultaneous and continuous kinetics of oxygen consumption and light emission during a complete exhaustion of the exogenous oxygen present in a closed system has been investigated. The kinetics are performed with Vibrio fischeri, V. harveyi, and Photobacterium phosphoreum incubated on respiratory substrates chosen for their different reducing power. The general patterns of the luminescence time courses are different among species but not among substrates. During steady-state conditions, substrates, which are less reduced than glycerol, have, paradoxally, a better luminescence efficiency. Oxygen consumption by luciferase has been evaluated to be approximately 17% of the total respiration. Luciferase is a regulatory enzyme presenting a positive cooperative effect with oxygen and its affinity for this final electron acceptor is about 4-5 times higher than the one of cytochrome oxidase. The apparent Michaelis constant for luciferase has been evaluated to be in the range of 20 to 65 nM O2. When O2 concentrations are as low as 10 nM, luminescence can still be detected; this means that above this concentration, strict anaerobiosis does not exist. By n-butyl malonate titration, it was clearly shown that electrons enter the luciferase pathway only when the cytochrome pathway is saturated. It is suggested that, in bioluminescent bacteria, luciferase acts as a free-energy dissipating valve when anabolic processes (biomass production) are impaired. [less ▲]

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See detailFrontières d’efficacité et processus d’appariement sur le marché du travail au Maroc
Ibourk, Aomar; Perelman, Sergio ULg

in Economie et Prévision (2001), (150-151), 33-45

La capacité d’un marché du travail à générer de nouveaux emplois à partir d’un stock donné de postes vacants et de chômeurs est interprétée comme une forme d’efficacité transactionnelle. Elle peut être ... [more ▼]

La capacité d’un marché du travail à générer de nouveaux emplois à partir d’un stock donné de postes vacants et de chômeurs est interprétée comme une forme d’efficacité transactionnelle. Elle peut être mesurée à partir de l’estimation d’une fonction d’appariement qui décrit la situation d’échange entre la demande, exprimée par les firmes, et l’offre, représentée par les travailleurs à la recherche d’un emploi. Dans cet article, nous proposons l’utilisation des techniques des frontières d’efficacité pour ces estimations. Deux méthodes alternatives, paramétrique et non paramétrique, sont appliquées au cas des marchés du travail régionaux au Maroc. Les résultats obtenus permettent une évaluation de l’efficacité des appariements sur chacun des marchés ainsi qu’une évaluation de l’activité des centres d’information et d’orientation pour l’emploi (CIOPE) qui ont été créés au début des années quatre-vingt-dix aux fins de faciliter l’appariement de l’offre et de la demande des diplômés. [less ▲]

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See detailLe domicile : une notion plurielle
d'Huart, Véronique ULg

in Répertoire notarial (2001), VII

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See detailTrophic diversiy within the eastern Weddell Sea amphipod community
Dauby, Patrick ULg; Scailteur, Yves; De Broyer, Claude

in Hydrobiologia (2001), 443

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See detailLes nouveaux critères de sélection porcine
Leroy, Pascal ULg

in Carrefour des Productions animales Gembloux (2001)

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See detailEvidence of rainbow trout prolactin interaction with its receptor through unstable homodimerisation.
Le Rouzic, Philippe; Sandra, Olivier; Grosclaude, Jeanne et al

in Molecular & Cellular Endocrinology (2001), 172(1-2), 105-13

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow ... [more ▼]

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow trout intestine cDNA library with a probe corresponding to the extracellular domain (ECD) of tilapia PRLR, we have cloned a 2.5 kb insert coding for the PRLR. The mature protein of 614 amino acid residues is similar to PRLR isolated in tilapia and also the long form of mammalian PRLR. Analysis of PRLR gene expression in osmoregulatory organs revealed the presence of a unique transcript, thus confirming the involvement of this hormone in the control of osmoregulation in this fish species. By using surface plasmon resonance (SPR) technology, kinetic measurement of interaction between trout PRL and its receptor ECD was studied. This approach allowed us to demonstrate the formation of a transient, unstable homodimeric complex. This unstability could explain the inability to perform binding experiments using homologous PRL. In contrast, heterologous lactogenic ligands were able to interact through a more stable complex. Whether these characteristics of PRL-receptor interaction in rainbow trout are different to what occurs in tilapia where a homologous radioreceptor assay was developed would require further studies. [less ▲]

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See detailThe Vacuum UV Photoabsorption spectrum of Methyl Chloride (CH3Cl) and its perdeuterated Isotopomer CD3Cl. II. A vibrational Analysis.
Locht, Robert ULg; Leyh, Bernard ULg; Hoxha, A. et al

in Chemical Physics (2001), 272

The fine structure of the vacuum UV photoabsorption spectrum of CH3Cl and CD3Cl has been analyzed in the 7.5-10.5 eV photon energy range. A large number of lines have been observed, classified and ... [more ▼]

The fine structure of the vacuum UV photoabsorption spectrum of CH3Cl and CD3Cl has been analyzed in the 7.5-10.5 eV photon energy range. A large number of lines have been observed, classified and assigned to vibrational excitation accompanying a series of Rydberg transitions. The vibronic transitions involve both Jahn-Teller distortion and spin-orbit splitting. The former effect has been evaluated by ab initio calculations showing that the 2E state (in the C3v symmetry group) splits into 2A' and 2A" states in the Cs symmetry group. The 2A' state is energetically the lowest component whereas the 2A" is found to be a transition state. The Jahn-Teller stabilisation energy and the wavenumbers associated with all vibrational modes have been calculated. Experimentally, the entire fine structure could be described by using the vibrational modes, i.e. hcomega5= 104+/-7 meV, hcomega6= 77+/-7 meV and homega=162+/-3 meV respectively, as resulting from an average over all the analyzed Rydberg states. In CD3Cl the corresponding energies are hcomega5= 81+/-4 meV, hcomega6= 66+/-5 meV and hcomega= 124+/-4 meV. These values are in good agreement with those predicted by the present ab initio calculations for the ion ground state. However, the agreement is not so good for the wavenumber omega which could be assigned to the nu3 or nu4 vibrational modes. Though some arguments favour nu4 (the CH3 umbrella mode), within the error limits on the present measurements it is formally not possible to ascribe this wavenumber to one of these two vibrations. [less ▲]

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See detailCharacterization of TRIP-assisted multiphase steel surface topography by atomic force microscopy
Ros-Yanez, Tanya; Houbaert, Yvan; Mertens, Anne ULg

in Materials Characterization (2001), 47

Transformation-induced plasticity (TRIP)-assisted multiphase steels have a complicated microstructure consisting of different phases, mainly ferrite, retained austenite, bainite and martensite. Atomic ... [more ▼]

Transformation-induced plasticity (TRIP)-assisted multiphase steels have a complicated microstructure consisting of different phases, mainly ferrite, retained austenite, bainite and martensite. Atomic force microscopy has been used for the phase identification and characterization of the phases in this kind of steel. A series of tests has been made on a C-Mn-Si and a C-Mn-Al TRIP-assisted steel after two different heat treatments: intercritical annealing followed by quench, and intercritical annealing followed by aging. After the aging process, the C-Mn-Al alloy was tempered in order to make metallographic observation easier, except the samples for mechanical testing, XRD or Mössbauer spectroscopy. It has been possible to identify the different phases and their topographic characteristics and to study their morphology using atomic force microscopy. The fine and complex microstructures of TRIP-assisted multiphase steels require improvements of the existing observation techniques, like electron backscattered diffraction and atomic force microscopy. Results of these techniques are presented. [less ▲]

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See detailThiazolidinediones and liver toxicity.
Scheen, André ULg

in Diabètes & Métabolism (2001), 27(3), 305-13

Thiazolidinediones or glitazones specifically target insulin resistance. They have proven efficacy for reducing plasma glucose levels of type 2 diabetic patients treated with diet alone, sulphonylureas ... [more ▼]

Thiazolidinediones or glitazones specifically target insulin resistance. They have proven efficacy for reducing plasma glucose levels of type 2 diabetic patients treated with diet alone, sulphonylureas, metformin or insulin. In addition, they may be associated to some improvement of cardiovascular risk profile. However, troglitazone, the first compound approved by the FDA in the US, proved to be hepatotoxic and was withdrawn from the market after the report of several dozens of deaths or cases of severe hepatic failure requiring liver transplantation. It remains unclear whether or not hepatotoxicity is a class effect or is related to the unique tocopherol side chain of troglitazone. Rosiglitazone and pioglitazone, two other glitazones, appear to have similar efficacy on blood glucose control of type 2 diabetic patients as compared to troglitazone. In controlled clinical trials, the incidence of significant increases in liver enzyme levels (ALT) was similar with rosiglitazone or pioglitazone as compared to placebo, whereas troglitazone was associated with a threefold greater incidence. In contrast to the numerous case reports of acute liver failure in patients receiving troglitzone, only two cases of severe reversible liver failure have been reported in patients treated with rosiglitazone, with a causal relationship remaining uncertain. Furthermore, no single case of severe hepatotoxicity has been reported yet with pioglitazone. While regular monitoring of liver enzymes is still recommended and more long-term data are desirable, current clinical evidence supports the conclusion that rosiglitazone and pioglitazone do not share the hepatotoxic profile of troglitazone. [less ▲]

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See detailLe concept d'insulinosensibilite
Scheen, André ULg

in Diabètes & Métabolism (2001), 27(2 Pt 2), 193-200

Insulin resistance was already suspected in the thirties from clinical observations in diabetic patients, then better appreciated in the early sixties with the development of insulin radioimmunoassay, and ... [more ▼]

Insulin resistance was already suspected in the thirties from clinical observations in diabetic patients, then better appreciated in the early sixties with the development of insulin radioimmunoassay, and finally confirmed in the last 20 years by using various sophisticated methods able to quantify insulin action. First demonstrated in obese and/or type 2 diabetic patients, the diminution of insulin sensitivity may in fact concern a much larger population. The concept of insulin sensitivity gained a considerable importance when Reaven, in 1988, emphasized the role of insulin resistance in different human diseases. The metabolic syndrome or syndrome X is characterized by the association of various cardiovascular risk factors (among which impaired glucose tolerance, arterial hypertension and dyslipidaemias), all closely linked to insulin resistance which is indeed the core of the syndrome. Even if insulin action signalling appears to be rather complex and the mechanisms leading to insulin resistance still largely unknown, it is essential to develop pharmacological or non pharmacological strategies to improve insulin sensitivity for treating insulin-resistant individuals. Such an approach should allow not only to provide a better blood glucose control in patients with type 2 diabetes, but also to improve the cardiovascular prognosis of numerous patients, with or without diabetes mellitus, who have the metabolic syndrome. [less ▲]

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See detailLe point sur le dépérissement de l’aulne
Claessens, Hugues ULg; Cavelier, Marc

in Forêt Wallonne (2001), 49/50

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See detailSuppression of matching field effects by splay and pinning energy dispersion in YBa2Cu3O7 with columnar defects
Niebieskikwiat, D.; Silhanek, Alejandro ULg; Civale, L. et al

in Physical Review. B : Condensed Matter (2001), 63(14),

We report measurements of the irreversible magnetization M-i of a large number of YBa2Cu3O7 single crystals with columnar defects (CD). Some of them exhibit a maximum in M-i when the density of vortices ... [more ▼]

We report measurements of the irreversible magnetization M-i of a large number of YBa2Cu3O7 single crystals with columnar defects (CD). Some of them exhibit a maximum in M-i when the density of vortices equals the density of tracks, at temperatures above 40 K. We show that the observation of these matching field effects is constrained to those crystals where the orientational and pinning energy dispersion of the CD system lies below a certain threshold. The amount of such dispersion is determined by the mass and energy of the irradiation ions, and by the crystal thickness. Time relaxation measurements show that the matching effects are associated with a reduction of the creep rate, and occur deep into the collective pinning regime. [less ▲]

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See detailHepatotoxicity with thiazolidinediones: is it a class effect?
Scheen, André ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (2001), 24(12), 873-88

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications ... [more ▼]

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications. Thiazolidinediones, more commonly termed glitazones, are the first drugs to specifically target muscular insulin resistance. They have proven efficacy for reducing plasma glucose levels in patients with type 2 diabetes mellitus treated with diet alone, sulphonylureas, metformin or insulin. In addition, they are associated with some improvement of the cardiovascular risk profile. However, troglitazone, the first compound approved by the Food and Drug Administration in the US, proved to be hepatotoxic and was withdrawn from the market after the report of several dozen deaths or cases of severe hepatic failure requiring liver transplantation. It remains unclear whether or not hepatotoxicity is a class effect or is related to unique properties of troglitazone. Rosiglitazone and pioglitazone, two other glitazones, appear to have similar efficacy with regard to blood glucose control in patients with type 2 diabetes mellitus as compared with troglitazone. In controlled clinical trials, the incidence of significant (> or =3 x upper limit of normal) increases in liver enzyme levels (ALT in particular) was similar with rosiglitazone or pioglitazone as compared with placebo, whereas troglitazone was associated with a 3-fold greater incidence. In contrast to the numerous case reports of acute liver failure in patients receiving troglitzone, only a few case reports of hepatotoxicity have been reported in patients treated with rosiglitazone until now, with a causal relationship remaining uncertain. Furthermore, no single case of severe hepatotoxicity has been reported yet with pioglitazone. It should be mentioned that troglitazone, unlike pioglitazone and rosiglitazone, induces the cytochrome P450 isoform 3A4, which is partly responsible for its metabolism, and may be prone to drug interactions. Importantly enough, obesity, insulin resistance and type 2 diabetes mellitus are associated with liver abnormalities, especially non-alcoholic steatohepatitis, independent of any pharmacological treatment. This association obviously complicates the selection of patients who are good candidates for a treatment with glitazones as well as the monitoring of liver tests after initiation of therapy with any thiazolidinedione compound. While regular monitoring of liver enzymes is still recommended and more long term data are desirable, current evidence from clinical trials and postmarketing experience in the US supports the conclusion that rosiglitazone and pioglitazone do not share the hepatotoxic profile of troglitazone. [less ▲]

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See detailMerisier : les variétés multiclonales ont-elles un avenir ?
Curnel, Yanick; van de waele, Isabelle; Jacques, Dominique et al

in Silva Belgica (2001), 108(2), 32-37

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See detailCommentaire
Richelle, Marc ULg

in Intellectica (2001), 33

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See detailL’administration publique et les technologies de l’information
Cornet, Annie ULg; Rondeaux, Giseline ULg

in Gestion : Revue Internationale de Gestion (2001), 26(1), 28-30

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See detailOriginal 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP channel activity
Somers, F.; Ouedraogo, R.; Antoine, M.-H. et al

in Journal of Medicinal Chemistry (2001), 44

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See detailRole of interface deformations in Benard-Marangoni instability
Lebon, Georgy ULg; Dauby, Pierre ULg; Regnier, Vincent

in Acta Astronautica (2001), 48(5-12), 617-627

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See detailEstimation of additive and nonadditive genetic variances in Hereford, Gelbvieh, and Charolais by Method R.
Duangjinda, M.; Bertrand, K.; Misztal, I. et al

in Journal of Animal Science (2001), 79(12), 2997-3001

Parameters for direct and maternal dominance were estimated in models that included non-additive genetic effects. The analyses used weaning weight records adjusted for age of dam from populations of ... [more ▼]

Parameters for direct and maternal dominance were estimated in models that included non-additive genetic effects. The analyses used weaning weight records adjusted for age of dam from populations of Canadian Hereford (n = 467,814), American Gelbvieh (n = 501,552), and American Charolais (n = 314,552). Method R estimates of direct additive genetic, maternal additive genetic, permanent maternal environment, direct dominance, and maternal dominance variances as a proportion of the total variance were 23, 12, 13, 19, and 14% in Hereford; 27, 7, 10, 18, and 2% in Gelbvieh; and 34, 15, 15, 23, and 2% in Charolais. The correlations between direct and maternal additive genetic effects were -0.30, -0.23, and -0.47 in Hereford, Gelbvieh, and Charolais, respectively. The correlations between direct and maternal dominance were -0.38, -0.02, and -0.04 in Hereford, Gelbvieh, and Charolais, respectively. Estimates of inbreeding depression were -0.20, -0.18, and -0.13 kg per 1% of inbreeding for Hereford, Gelbvieh, and Charolais, respectively. Estimates of the maternal inbreeding depression were -0.01, -0.02, and -0.02 kg, respectively. The high ratio of direct dominance to additive genetic variances provided some evidence that direct dominance effects should be considered in beef cattle evaluation. However, maternal dominance effects seemed to be important only for Hereford cattle. [less ▲]

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See detailHST and ground-based observations of the gravitational lens system Q1009-0252 A & B
Claeskens, Jean-François ULg; Khmil, S. V.; Lee, Dong Wook et al

in Astronomy and Astrophysics (2001), 367

In this paper, we propose a critical study of direct images and spectra obtained for the doubly imaged QSO Q1009-0252 A & B (=LBQS1009-0252 A & B). First, we report new observations with the WFPC2 onboard ... [more ▼]

In this paper, we propose a critical study of direct images and spectra obtained for the doubly imaged QSO Q1009-0252 A & B (=LBQS1009-0252 A & B). First, we report new observations with the WFPC2 onboard the Hubble Space Telescope (HST), in which the lensing galaxy is very clearly detected. We combine these with existing NICMOS observations in order to characterize the nature and redshift of the lens. Our HST observations are also fitted with simple analytical lens models; estimates expected for the time delay and M/L of the lensing galaxy are derived. Secondly, new and existing ground-based observations are used in order to establish the first multicolour lightcurves of the lensed components. Although the time resolution is low, flux variability is detected for both components. Finally, ground-based spectroscopic observations published by Surdej et al. (1993) are re-processed with a new method designed to extract spectra with small angular separations. The final spectra are analysed on the basis of a simple model including macrolensing and microlensing amplifications and dust extinction. Based on observations collected at the European Southern Observatory (La Silla, Chile) and with the Hubble Space Telescope. [less ▲]

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See detailTriassic and Jurassic lithostratigraphic units (Belgian Lorraine)
Boulvain, Frédéric ULg; Belanger, I.; Delsate, D. et al

in Geologica Belgica (2001), 4(1-2), 113-119

A multidisciplinary study of some extensively cored boreholes together with the new 1/25,000 geological mapping of Wallonia led us to propose a new lithostratigraphic canvas for Belgian Lorraine. This ... [more ▼]

A multidisciplinary study of some extensively cored boreholes together with the new 1/25,000 geological mapping of Wallonia led us to propose a new lithostratigraphic canvas for Belgian Lorraine. This area is located on the NE border of the Paris Basin, south of the Ardennes; the studied stratigraphic interval covers the Keuper to the Bajocian. [less ▲]

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See detailDietary habits during adolescence - results of the Belgian Adolux Study
Paulus, Dominique; Saint-Remy, Annie ULg; JeanJean, Michel

in European Journal of Clinical Nutrition (2001), 55

STUDY: To analyse the usual dietary habits of Belgian adolescents from a high cardiovascular risk population. METHODS: A food frequency questionnaire (57 items) was administered to the whole sample ... [more ▼]

STUDY: To analyse the usual dietary habits of Belgian adolescents from a high cardiovascular risk population. METHODS: A food frequency questionnaire (57 items) was administered to the whole sample. Complementary questions specified some types of food (eg fat content). A subgroup of 234 adolescents gave detailed information on portion size (picture book and food samples). SETTING: Twenty-four secondary schools in the Belgian province of Luxembourg. SUBJECTS: A total of 1,526 adolescents (12-17y) selected by a multiclustered stage sampling (participation: 83.6%). RESULTS: Respectively 46% and 60% of the adolescents did not eat fruit and vegetables daily. Most of the adolescents (72%) consumed at least one dairy product daily. The frequent consumption of chocolate and French fries indicated the strong cultural influence on dietary habits while imported foods (like hamburgers) had little success. One-third of the adolescents (33%, n = 509) drank alcohol at least once a week and this proportion rose to 57% in the oldest age group. Boys and girls differed significantly in their diet, with girls choosing healthier foods. Dietary habits, in particular drinking habits, differed also significantly between education levels, assessed by the learning option of the participants. The semi-quantitative questionnaire showed that two-thirds of the adolescents had a lipid intake (mainly saturated fatty acids) which exceeded 35% of the total caloric intake. Complex carbohydrates represented less than half of the total carbohydrates intake. CONCLUSION: The study of the diet of Belgian adolescents confirmed the strong influence of tradition, in particular on the consumption of high fat content foods. The promotion of healthy diet in adolescents should consider the cultural influence, even for this young age group [less ▲]

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See detailAvancées récentes en biologie moléculaire du virus de la diarrhée virale bovine
Dehan, Pierre ULg; Hamers, C.; Couvreur, B. et al

in Annales de Médecine Vétérinaire (2001), 145

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See detailPropositions relatives à l'enseignement
de Landsheere, Gilbert ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (5-6), 79-84

Comme pour le texte 'L'avenir de l'enseignement' qui est publié dans ces Cahiers, il s'agit d'un texte qui date d'une dizaine d'années. Ces propositions ont été formulées peu de temps après la ... [more ▼]

Comme pour le texte 'L'avenir de l'enseignement' qui est publié dans ces Cahiers, il s'agit d'un texte qui date d'une dizaine d'années. Ces propositions ont été formulées peu de temps après la communautarisation complète de l'enseignement. A présent que 'nous sommes maîtres chez nous', qu'en est-il ? Quel chemin avons-nous parcouru ? S'agissait-il de prémonitions ? De rêves et d'utopies ? Chacun peut s'en faire une idée. Chacun peut aussi apprécier, sur la base d'un texte, ce qui se disait alors et ce que Gilbert de Landsheere envisageait comme souhaitable. [less ▲]

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See detailEuthanasia: a law in Belgium?
Damas, François ULg; Damas, Pierre ULg; Lamy, Maurice ULg

in Intensive Care Medicine (2001), 27(10), 1683

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See detailMolecular identification of three sympatric species of wood mice (Apodemus sylvaticus, A-flavicollis, A-alpicola) in western Europe (Muridae : Rodentia)
Michaux, Johan ULg; Kinet, Séverine ULg; Filippucci, M. G. et al

in Molecular Ecology Notes (2001), 1(4), 260-263

The woodmouse (Apodemus sylvaticus) and yellow-necked fieldmouse (Apodelnus flavicollis) are sympatric and even syntopic in many regions throughout their European range. Their field discrimination on the ... [more ▼]

The woodmouse (Apodemus sylvaticus) and yellow-necked fieldmouse (Apodelnus flavicollis) are sympatric and even syntopic in many regions throughout their European range. Their field discrimination on the basis of external characters is a real challenge for many fields of research. The problem is even more complicated in the Alpine chain where they live sympatrically with a third similar species: A. alpicola. A rapid and simple method is proposed to discriminate the three species in processing field-collected biopsies as well as ethanol-preserved museum samples. [less ▲]

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See detailAntimicrobial susceptilities of Campylobacter strains isolated from food animals in Belgium.
Van Looveren, M.; Daube, Georges ULg; De Zutter, L. et al

in Journal of Antimicrobial Chemotherapy (2001), 48

Afin d’assurer une transparence tout le long de la chaîne de transformation de la viande, il faut disposer d’un système de traçabilité performant. La traçabilité administative montre des limites que ... [more ▼]

Afin d’assurer une transparence tout le long de la chaîne de transformation de la viande, il faut disposer d’un système de traçabilité performant. La traçabilité administative montre des limites que l’utilisation de marqueurs génétiques pourrait surmonter. Le génome de chaque individu possède des différences de séquences, à la base du polymorphisme génétique, dont les marqueurs génétiques sont les témoins. Parmi ceux-ci, deux classes semblent s’imposer en matière de traçabilité : les microsatellites et les polymorphismes simple nucléotide. Les microsatellites sont caractérisés par un degré de polymorphisme important avec de nombreux allèles pour un même locus. De plus, leur détection se fait directement par amplification itérative. Techniquement, le problème se pose lors de la détection simultanée de plusieurs microsatellites où le patron obtenu est difficile à interpréter. Les polymorphismes simple nucléotide sont répresentés par des mutations ponctuelles dans la séquence nucléotidique. Ils sont fréquents, stables, répartis de façon aléatoire et généralement bialléliques. La détection se fait soit par hybridation sur des biopuces, soit par spectrométrie de masse ou par d’autres techniques facilement automatisables. Cette automatisation est nécessaire pour pouvoir tester un grand nombre de polymorphismes simultanément sur un grand nombre d’échantillons, permettant ainsi de diminuer les coûts. L’avantage majeur des polymophismes simple nucléotide est le signal binaire obtenu, son désavantage est le caractère population- spécifique de ce type de marqueur. [less ▲]

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See detailMass transfer in low-density xerogel catalysts
Heinrichs, Benoît ULg; Pirard, Jean-Paul ULg; Schoebrechts, Jean-Paul

in AIChE Journal (2001), 47(8), 1866-1873

Texture and morphology of a Pd-Ag/SiO2 hydrodechlorination low-density xerogel catalyst prepared by a cogelation sot-gel process were characterized in detail to examine mass transfer in such catalysts ... [more ▼]

Texture and morphology of a Pd-Ag/SiO2 hydrodechlorination low-density xerogel catalyst prepared by a cogelation sot-gel process were characterized in detail to examine mass transfer in such catalysts. The catalyst consists of active Pd-Ag nanocrystallites trapped inside elementary 20 nm microporous silica particles arranged in larger aggregates, which constitute the macroscopic pellet. To reach active sites, reactants must first diffuse through large pores located between aggregates of SiO2 Particles and then through smaller pores located between those elementary particles inside the aggregates. Finally, they, diffuse through micropores located inside silica particles. Diffusion in such a "funnel" structure cannot be described assimilating the pellet to a pseudo-continuum. Diffusion should be examined carefully at three levels of decreasing size: the macroscopic pellet, the aggregate of silica particles, and the elementary silica particle. This approach shows that cogelled xerogel catalysts have remarkable mass-transfer properties. [less ▲]

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See detailImage analysis, impedance spectroscopy and mercury porosimetry characterisation of freeze-drying porous materials
Blacher, Silvia ULg; Maquet, Véronique; Pirard, René ULg et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2001), 187-188

Image analysis and impedance spectroscopy have been used as potential tools for the characterization of the texture of ultramacroporous PLA foams prepared by freeze-drying. It has been shown that these ... [more ▼]

Image analysis and impedance spectroscopy have been used as potential tools for the characterization of the texture of ultramacroporous PLA foams prepared by freeze-drying. It has been shown that these two techniques actually provide valuable information on the structure of this material. They are complementary to mercury porosimetry, which does not allow morphological details to be distinguished. Image analysis of SEM micrographs of transverse cross-sections at two different magnifications gave information on both the macroporosity (1 μm < width < 10 μm) and ultramacroporosity (width > 10 μm). Impedance spectroscopy was used to investigate the transport properties of the three-dimensional porous matrices by measurement of ionic conduction [less ▲]

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See detailInfo-congres. La cochrane collaboration, porte-parole de la medecine factuelle.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(11), 796-8

During the 9th International Cochrane Colloquium (Lyon October 9-13, 2001), around 700 participants discussed about how to make the evidence dissemination process more efficient in order to promote the ... [more ▼]

During the 9th International Cochrane Colloquium (Lyon October 9-13, 2001), around 700 participants discussed about how to make the evidence dissemination process more efficient in order to promote the Evidence-Based Medicine. The best evidence is summarized in systematic reviews of randomised and/or controlled clinical trials within the Cochrane Library which are prepared with a high methodological quality. However, these reviews should be completed to cover all medical domains, be actualized regularly, and, most importantly, be better known and more largely used by physicians in routine practice. All these objectives could not be attained without an official recognition and a financial support by the public health authorities. [less ▲]

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See detailDevelopment of a test battery for assessing cognitive functions of elderly patients with Down syndrome
Georges, Michel ULg; Thewis, B.; Van der Linden, Martial ULg et al

in Revue de Neuropsychologie (2001), 11(4), 549-579

Post-mortem studies of Down syndrome (DS) individuals older than 35 years show that almost 100% of them develop the neuropathological symptoms of Alzheimer disease (AD). A test battery designed to assess ... [more ▼]

Post-mortem studies of Down syndrome (DS) individuals older than 35 years show that almost 100% of them develop the neuropathological symptoms of Alzheimer disease (AD). A test battery designed to assess several domains of cognition was administered to a group of 12 DS individuals older than 35 years. It proved sensitive to individual differences and thus appears to be appropriate for the observation of cognitive change linked to age. Statistical analyses do not reveal cognitive changes in the DS subjects after one year time. However qualitative analyses of individual profiles suggest a cognitive decline in one subject. Additionally, in a PET-scan examination, three subjects present a mild decrease in cerebral glucose metabolism similar to that usually observed in AD. An AD diagnostic though remains uncertain at this stage. [less ▲]

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See detailEffect of conventional controlled-rate freezing and vitrification on quality of bovine blasotcysts produced in vitro
Kaidi, Safia; Bernard, S.; Lambert, Philippe ULg et al

in Biology of Reproduction (2001), 65

This study compares the effects of conventional controlled-rate freezing and vitrification on the morphology and metabolism of in vitro-produced bovine blastocysts. Day 7 expanded blastocysts cultured in ... [more ▼]

This study compares the effects of conventional controlled-rate freezing and vitrification on the morphology and metabolism of in vitro-produced bovine blastocysts. Day 7 expanded blastocysts cultured in synthetic oviduct fluid with 5% fetal calf serum were frozen in 1.36 M glycerol, 0.25 M sucrose or vitrified in 25% glycerol, 25% ethylene glycol. Cell alterations and in vitro development were evaluated immediately after thawing or after 72 h. The effect of cryopreservation on inner cell mass and trophectoderm (TE) cell number as well as glucose, pyruvate, and oxygen uptakes, and lactate release by blastocysts were evaluated. Immediately after thawing, blastocysts showed equivalent cell membrane permeabilization after both cryopreservation procedures, while alterations in nuclear staining were more frequent in vitrified embryos. After culture, similar survival and hatching rates were observed. Both procedures decreased cell number immediately after thawing and after 72 h. However, the number of TE cells was lower in frozen embryos than in vitrified ones. In relation to this, frozen blastocysts showed a decrease in glucose, pyruvate, and oxygen uptake, although those parameters were not altered in vitrified embryos. An increased glycolytic activity was also observed in frozen embryos, indicating a stress response to this procedure. [less ▲]

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See detailDown-Regulation of MT1-MMP expression by the alpha3 chain of type IV collagen inhibits bronchial tumor cell line invasion
Martinella-Catusse, C.; Polette, M.; Noël, Agnès ULg et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2001), 81

The basement membrane (BM) is the first barrier encountered by tumor cells when they become invasive. Moreover, some invasive tumor clusters are surrounded by a remnant or neosynthetized BM material. We ... [more ▼]

The basement membrane (BM) is the first barrier encountered by tumor cells when they become invasive. Moreover, some invasive tumor clusters are surrounded by a remnant or neosynthetized BM material. We have previously reported the presence of a particular alpha chain of type IV collagen, the alpha3(IV) chain, in bronchopulmonary carcinomas. This chain was not detected in the normal bronchial epithelium, but was found around some invasive tumor cluster BM. In the present study, we examined the effects of the alpha3(IV) chain on the invasive properties of bronchial tumor cell lines, with special emphasis on their expression of matrix metalloproteinase-2 (MMP-2) and its activator, membrane type 1-matrix metalloproteinase (MT1-MMP), which is largely involved in tumor progression. Two epithelial bronchial cell lines (16HBE14o- and BZR), showing different invasive abilities, were evaluated. Using the Boyden chamber invasion assay, we demonstrated that the alpha3(IV) chain inhibits the invasive properties of BZR cells and modifies their morphology by inducing an epithelial cell shape. In the presence of the recombinant NC1 domain of the alpha3(IV) chain, the expression of MMP-2 and tissue inhibitor of metalloproteinase-2 (TIMP-2) was not modified in either cell line. The NC1 alpha3(IV) domain did not modulate the MT1-MMP expression of noninvasive 16HBE14o- cells, whereas a 50% decrease of MT1-MMP mRNA was observed in invasive BZR cells. Accordingly, Western blot analyses showed a disappearance of the 45-kd MT1-MMP form when BZR cells were treated with the recombinant NC1 alpha3(IV) domain. These findings suggest that the alpha3 chain of type IV collagen may play a role in tumor invasion, at least by decreasing the expression and synthesis of MT1-MMP. [less ▲]

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See detailDe l'utilité de la modélisation numérique en hydrodynamique de surface
Archambeau, Pierre ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Ingenieurbiologie / Génie Biologique (2001), (4), 9-20

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See detailModélisation numérique de processus de transport sédimentaire en rivière
Dewals, Benjamin ULg

in Tribune de l'Eau (La) (2001), 54(611), 45-56

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See detailDégradation de dalles de tablier de ponts en Belgique. Etude d'une pathologie complexe
Demars, Philippe; Gilles, Pierre; Darimont, Anne ULg

in Bulletin des Laboratoires des Ponts et Chaussées (2001), 232

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See detailRecent biogeographic and ecological studies on otter (Lutra lutra) and European mink (Mustela lutreola) in France
de Bellefroid, Marie des Neiges; Libois, Roland ULg; Rosoux, René

in Säugetierkundliche informationen (2001), 25

Otter and European mink are two threatened species in France. The mink is even considered to be on the verge of extinction. Studies have been carried out for more than ten years to attempt to understand ... [more ▼]

Otter and European mink are two threatened species in France. The mink is even considered to be on the verge of extinction. Studies have been carried out for more than ten years to attempt to understand the changes in their distribution and the ecological needs of these two semi-aquatic mustelids. The results of the research programmes completed or still under way, are presented. The French Ministry of Environment has set up two specific restoration plans, with the contribution of Conversation societies for wild fauna and scientific institutions. [less ▲]

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See detailResonance-assisted tunneling in near-integrable systems
Brodier, O.; Schlagheck, Peter ULg; Ullmo, D.

in Physical Review Letters (2001), 87(6), 064101

Dynamical tunneling between symmetry related invariant tori is studied in the near-integrable regime. Using the kicked Harper model as an illustration, we show that the exponential decay of the wave ... [more ▼]

Dynamical tunneling between symmetry related invariant tori is studied in the near-integrable regime. Using the kicked Harper model as an illustration, we show that the exponential decay of the wave functions in the classically forbidden region is modified due to coupling processes that are mediated by classical resonances. This mechanism leads to a substantial deviation of the splitting between quasidegenerate eigenvalues from the purely exponential decrease with 1/(h) over bar obtained for the integrable system. A simple semiclassical framework, which takes into account the effect of the resonance substructure on the invariant tori, allows one to quantitatively reproduce the behavior of the eigenvalue splittings. [less ▲]

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See detailRapport sur le “Workshop on the open archive initiative (OAI) and peer review journals in Europe” - Genève (CERN) 22 au 24 mars 2001
Jérôme, Simone

in Cahiers de la Documentation = Bladen voor Documentatie (2001), (4), 59-63

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See detailHelioseismic Tests of the New Los Alamos LEDCOP Opacities
Neuforge-Verheecke, C.; Guzik, J. A.; Keady, J. J. et al

in Astrophysical Journal (2001), 561(1), 450-454

We compare the helioseismic properties of two solar models, one calibrated with the OPAL opacities and the other with the recent Los Alamos LEDCOP (Light Element Detailed Configuration Opacity) opacities ... [more ▼]

We compare the helioseismic properties of two solar models, one calibrated with the OPAL opacities and the other with the recent Los Alamos LEDCOP (Light Element Detailed Configuration Opacity) opacities. We show that, in the radiative interior of the Sun, the small differences between the two sets of opacities (up to 6% near the base of the convection zone) lead to noticeable differences in the solar structure (up to 0.3% in sound speed), with the OPAL model being the closest to the helioseismic data. More than half of the difference between the two opacity sets results from the interpolation scheme and from the relatively widely spaced temperature grids used in the tables. The remaining 3% intrinsic difference between the OPAL and the LEDCOP opacities in the radiative interior of the Sun is well within the error bars on the opacity calculations resulting from the uncertainties on the physics. We conclude that both the OPAL and LEDCOP opacities produce solar models in close agreement with helioseismic inferences, but discrepancies still persist at the level of 0.6% between the calculated and inferred sound speed in the radiative interior of the Sun. [less ▲]

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See detailOn the symmetry of the age field of a passive tracer released into a one-dimensional fluid flow by a point-source
Deleersnijder, E.; Delhez, Eric ULg; Crucifix, M. et al

in Bulletin de la Société Royale de Liège (2001), 70

Tracer is released from a point-source into an incompressible, one-dimensional fluid flow, with constant velocity and diffusivity. The age of a tracer parcel, which is defined as the time elapsed since ... [more ▼]

Tracer is released from a point-source into an incompressible, one-dimensional fluid flow, with constant velocity and diffusivity. The age of a tracer parcel, which is defined as the time elapsed since leaving the source, may be evaluated as the ratio of the age concentration to the tracer concentration. The latter are governed by two partial differential equations. Time-dependent analytical solutions are derived, which show that the age is symmetric with respect to the source. This is astonishing, since it could have been expected that the age would reflect somehow the strong asymmetry of the tracer concentration, which tends to be much larger on the downstream side of the source than on the upstream side. Some finite-difference counterparts of this problem are seen to lead to age fields which, in their steady-state limit, are also symmetric with respect to the source. This is believed to be helpful to interpret the results of numerical models of complex fluid flows in which the age is introduced as a diagnostic variable. [less ▲]

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See detailAtomic transition probabilities in Bi II
Palmeri, P.; Quinet, Pascal ULg; Biémont, Emile ULg

in Physica Scripta (2001), 63

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See detailCell cycle activation of hematopoietic progenitor cells increases very late antigen-5-mediated adhesion to fibronectin.
Giet, Olivier ULg; Huygen, Sandra; Beguin, Yves ULg et al

in Experimental hematology (2001), 29(4), 515-24

Recent studies suggested that trafficking of hematopoietic progenitor cells is related to cell cycle status. We studied whether adhesion of progenitor cells to extracellular matrix proteins was modulated ... [more ▼]

Recent studies suggested that trafficking of hematopoietic progenitor cells is related to cell cycle status. We studied whether adhesion of progenitor cells to extracellular matrix proteins was modulated by cell cycle transit.Mobilized peripheral blood CD34+ cells were stimulated ex vivo for 48 hours with stem cell factor, flt-3 ligand, and thrombopoietin and fractionated by adhesion to fibronectin or vascular cell adhesion molecule-1 (VCAM-1). Adherent and nonadherent cells were assayed for cell cycle status, long-term culture-initiating cell frequency, and integrin function. Binding to fibronectin, but not to VCAM-1, displayed a cell cycle selectivity as the adherent fraction to fibronectin was enriched in cycling CD34+ cells and in cycling long-term culture-initiating cells compared to the nonadherent fraction. Combined cell cycle and phenotypic analysis showed that the expression of VLA-5 was upregulated during S/G2+M but that of VLA-4 remained constant. The selective binding of cycling CD34+ cells to fibronectin was reverted by anti-VLA-5 but not by anti-VLA-4 blocking antibodies. Also, cycling CD34+ cells preferentially adhered to the VLA-5 binding domain but not to the VLA-4 binding domain of fibronectin. Adhesion of cycling CD34+ cells to fibronectin was a reversible process modulated by cell cycle progression, because adherent cells could exit the cell cycle and return to a nonadhesive state within an additional 48-hour culture period.The results indicate that the enhanced binding capacity of cycling progenitor cells to fibronectin is mediated by VLA-5. [less ▲]

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See detailLe déroulement de la conférence sur le développement rural durable dans l'ensemble des pays d'Europe.
Christians, Charles ULg; Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (2001), 41

Présentation de l'organisation, du thème, de l'objectif et des activités (travaux sur le terrain et Conférence).

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See detailM. Migeotte
Biémont, Emile ULg

in Nouvelle Bibliographie Nationale, Académie Royale de Belgique (2001), 6

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See detailRésumé C.E. n°89.185, du 31 juillet 2000, Van Den Borre
Delnoy, Michel ULg

in Aménagement - Environnement (2001), 1

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See detailVoix de la mémoire et causes obscures
Gauthier, Jean-Marie ULg

in Cahiers de Psychologie Clinique (2001), 16

Freud a établi un lien très fort entre Inconscient et temporalité puisque, à l'inverse de toutes nos autres productions personnelles, seul celui-ci ne subirait pas les outrages du temps. Ce texte tente de ... [more ▼]

Freud a établi un lien très fort entre Inconscient et temporalité puisque, à l'inverse de toutes nos autres productions personnelles, seul celui-ci ne subirait pas les outrages du temps. Ce texte tente de montrer l'importance et la richesse de cette intuition freudienne à travers l'analyse du film de W. Wenders, 'Lisbon Story'. Il nous faut alors, pour reprendre les propos de Freud constater que la structure de nos temporalités intérieures est complexe, à la fois immuable et en perpétuelle transformation. [less ▲]

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See detailStability of perturbed functional differential equations and stabilization of nonlinear cascades
Michiels, Wim; Sepulchre, Rodolphe ULg; Roose, Dirk

in SIAM Journal on Control & Optimization (2001), 40

In this paper the effect of bounded input perturbation on the stability of nonlinear globally asymptotically stable delay differential equations is analyzed. We investigate under which conditions global ... [more ▼]

In this paper the effect of bounded input perturbation on the stability of nonlinear globally asymptotically stable delay differential equations is analyzed. We investigate under which conditions global stability in preserved and if not, whether semi-global stabilization is possible by controlling the size or shape of the perturbation. This results in a general framework, in which the stabilization of partial linear cascade systems using partial state feedback can be treated systematically. [less ▲]

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See detailSmectite composition as a tracer of deep circulation: the case of the Northern North Atlantic
Fagel, Nathalie ULg; Robert, Christian; Preda, Michel et al

in Marine Geology (2001), 172(3-4), 309-330

The link between smectite composition in sediments from the northern North Atlantic and Labrador Sea, and deep circulation is being further investigated through detailed studies of the X-ray pattern of ... [more ▼]

The link between smectite composition in sediments from the northern North Atlantic and Labrador Sea, and deep circulation is being further investigated through detailed studies of the X-ray pattern of smectites and cation saturations. This allows clear distinction of dominant terrigenous sources associated to the main components of the modern Western Boundary Undercurrent. Time variations of smectite characteristics in two piston cores from the inlet and outlet of the Western Boundary Undercurrent gyre in the Labrador Sea indicate: (1) a more southern circulation of North East Atlantic Deep Water during the Late Glacial; (2) a step by step transition to the modern pattern of deep circulation during the Late Glacial/Holocene transition, with intensification of North East Atlantic Deep Water and Davis Strait Overflow; (3) an expansion of Davis Strait Overflow and Labrador Sea Water circulation in relation to ice surges and deposition of detrital layers; (4) an intensified circulation of North East Atlantic Deep Water during the Younger Dryas; and (5) a very recent increased influence of Denmark Strait Overflow Water beginning between 4.4 and <1 kyr. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailComparison by image processing of target supports of spray droplets
Degre, Aurore ULg; Mostade, Olivier; Huyghebaert, Bruno et al

in transaction of the American society of Agricultural engineers (2001), 44(2), 217-222

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See detailCriterii de differentiere a unor specii de Veronica
Crisan, Gianina; Tamas, M.; Garbacki, Nancy ULg et al

in Farmacia (2001), 49(6), 67-73

We have tried to establish some criteria to avoid the substitution of Veronica officinalis L; with anti-ulcer and anti-inflammatory activities with other species of the genus Veronica, especially Veronica ... [more ▼]

We have tried to establish some criteria to avoid the substitution of Veronica officinalis L; with anti-ulcer and anti-inflammatory activities with other species of the genus Veronica, especially Veronica chamaedrys L. widely spread and without therapeutic use. We have studied the different histological, anatomical and phytochemical characters for the two species. A rapid method for the identification of both species is the TLC for flavonoids and phenylpropanic compounds was described. Moreover HPLC is useful to detect the presence of acteoside only in Veronica chamaedrys, while Veronica officinalis contains isoacteoside. [less ▲]

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See detailIsokinetic evaluation of hip strength muscle groups in unilateral lower limb amputees
Croisier, Jean-Louis ULg; Maertens De Noordhout, Benoît ULg; Maquet, Didier ULg et al

in Isokinetics & Exercise Science (2001), 9(4), 163-169

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order ... [more ▼]

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order to improve the usual rehabilitation programs. Thirty-three patients with unilateral lower limb amputation were included in this study; they served as their own controls, the amputated side being compared to the intact side. Using an isokinetic device, the relative peak torques (N.m by body weight), bilateral asymmetries and agonist/antagonist torque ratios were calculated for the hip flexor, extensor, adductor and abductor muscle groups. A significant reduction of mean concentric relative peak torque measured on the amputated limbs was generally observed when compared to the intact contralateral limb (p < 0.05). The mean percentage of relative peak torque decrease was greater for the extensors than for the flexors (33 +/- 20% and 22 +/- 23%, respectively, at 30degrees/s angular velocity), and for the abductors than for the adductors (23 +/- 22% and 11 +/- 19%, respectively, at 30degrees/s angular velocity). Furthermore, the flexor/extensor torque ratio was significantly increased for the amputated limb (for instance, 1.25 +/- 0.33 versus 1.09 +/- 0.25 for the intact limb at 30degrees/s). The reduction of the abductor/adductor ratio of the operated limb reached the level of statistical significance at 60degrees/s only (1.25 +/- 0.46 versus 1.07 +/- 0.36 for the intact limb). In conclusion, isokinetic testing revealed a significant reduction of the hip stabilizing muscle strength as a consequence of lower limb amputation. The more marked decrease of the strength of the abductor and extensor muscle groups, resulting in imbalances of the agonist/antagonist strength ratios should be taken into account to adapt the conventional rehabilitation programs. [less ▲]

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See detailPex, Analytical Tools For Pdb Files. II. H-Pex: Noncanonical H-Bonds In Alpha-Helices
Thomas, Annick ULg; Benhabiles, N.; Meurisse, R. et al

in Proteins-Structure Function and Genetics (2001), 43(1), 37-44

We use the H-Pex (Thomas et al., this issue) to analyze the main chain interactions in 131 proteins. In antiparallel beta-sheets, the geometry of the N...O bond is: median N...O distances, 2.9 SA, C==O ... [more ▼]

We use the H-Pex (Thomas et al., this issue) to analyze the main chain interactions in 131 proteins. In antiparallel beta-sheets, the geometry of the N...O bond is: median N...O distances, 2.9 SA, C==O...N angles at 154 degrees and the C alpha--C==O...H angles are dispersed around 3 degrees. In some instances, the other side of the C==O axis is occupied by a HC alpha. As recently supported by Vargas et al. (J Am Chem Soc 2000;122:4750-4755) C alpha H...O and NH...O could cooperate to sheet stability. In alpha-helices, the main chain C==O interact with the NH of their n + 4 neighbor on one side, and with a C beta H or C gamma H on the other side. The median O...N distance (3.0 A) and C==N angle (147 degrees) suggest a canonical H-bond, but the C alpha--C==O...H dihedral angle invalidates this option, since the hydrogen attacks the oxygen at 122 degrees, i.e., between the sp(2) and pi orbitals. This supports that the H-bond is noncanonical. In many instances, the C gamma H or the C beta H of the n + 4 residue stands opposite to the NH with respect to the oxygen. Therefore, we propose that, in alpha-helices, the C gamma H or C beta H and the NH of the n + 4 residue hold the oxygen like an electrostatic pincher. [less ▲]

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See detailEmissions gazeuses en élevage porcin et modes de réduction : revue bibliographique
Degre, Aurore ULg; Verheve, Didier; Debouche, Charles ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(3), 135-143

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See detailLucien Lambotte, esquisse biographique
Pirenne, Christophe ULg

in Revue de la Société liégeoise de Musicologie (2001), 18

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See detailInfluence of electrical properties on the evaluation of the surface hydrophobicity of Bacillus subtilis
Ahimou, F.; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Journal of Microbiological Methods (2001), 45(2), 119-126

The surface hydrophobicity of nine Bacillus subtilis strains in different states (spores, vegetative cells, and dead cells) was assessed by water contact angle measurements, hydrophobic interaction ... [more ▼]

The surface hydrophobicity of nine Bacillus subtilis strains in different states (spores, vegetative cells, and dead cells) was assessed by water contact angle measurements, hydrophobic interaction chromatography (HIC) and bacterial adhesion to hydrocarbon (BATH). Electrokinetic properties of B, subtilis strains were characterized by zeta potential measurements and found to differ appreciably according to the strain, Correlations between HIC data, BATH data and zeta potential showed that HIC and RATH are influenced by electrostatic interactions. Water contact angle measurements thus provide a better estimate of cell surface hydrophobicity. The water contact angle of B. subtilis varied according to the strain and the state, the spores tending to be more hydrophobic than vegetative cells. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailSpirometric performance in Belgian Blue calves: I. Effects on economic losses due to the bovine respiratory disease complex.
Bureau, Fabrice ULg; Detilleux, Johann ULg; Dorts, T. et al

in Journal of Animal Science (2001), 79(5), 1301-1304

The aim of this study was to determine whether high spirometric performances in calves are associated with low economic losses due to the bovine respiratory disease complex (BRDC). Five spirometric ... [more ▼]

The aim of this study was to determine whether high spirometric performances in calves are associated with low economic losses due to the bovine respiratory disease complex (BRDC). Five spirometric variables (SV) were measured in 909 double-muscled Belgian Blue calves from 15 to 60 d of age. Afterward, calves were monitored for 6 mo to determine whether they developed BRDC and to determine the costs due to BRDC (i.e., medicine costs and veterinarians' fees, plus estimated financial losses due to mortality in case of death). To analyze the effects of spirometric performances on BRDC cost, a fixed linear model was used for each SV. In addition to SV, each model included the effects of sex, dam's parity, vaccination status, muscular development score, herd-period, and BW. Only herd-period and the maximal ventilation and the vital capacity had significant effects on costs due to BRDC, indicating that these two SV are major physiological determinants of economic losses associated with BRDC. Accordingly, it is assumed that an amelioration of maximal ventilation and vital capacity could result in increased resistance to BRDC in calves. [less ▲]

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See detail3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detailACTH silent adenoma shrinking under cabergoline.
Petrossians, Patrick ULg; Ronci, N.; Valdes Socin, Hernan Gonzalo ULg et al

in European Journal of Endocrinology (2001), 144(1), 51-57

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non ... [more ▼]

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non-functioning pituitary adenomas. DESIGN: Following the clinical and radiological improvement of a recurrent silent ACTH adenoma in a 77-year-old patient treated with cabergoline (0.5 mg every 2 days for 2 years), in vitro studies of the original tumor were performed. METHODS: The original tumor from the patient was studied by in situ hybridization and dopamine D2 receptor autoradiography. It was compared with four macroprolactinomas and two macroadenomas from patients with Cushing's disease. RESULTS: The D2 receptor mRNA signal of the reported case was intense and of the same order of magnitude as that observed in control prolactinomas. Dopamine D2 receptor autoradiography was twice that of control corticotroph adenomas and was close to that observed in prolactinomas. CONCLUSIONS: This is the first description of an in vivo shrinkage of an ACTH silent adenoma under cabergoline. We demonstrate in vitro, the presence of D2 receptors in the primitive tumor in concentrations similar to those found in control prolactinomas. These results suggest that therapeutic trials with cabergoline might be undertaken in recurring cases of ACTH silent tumors and more generally, non-functioning pituitary adenomas. [less ▲]

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See detailSpectroscopic evidence for high-altitude Aurora at Jupiter from Galileo Extreme Ultraviolet Spectrometer and Hopkins Ultraviolet Telescope observations
Ajello, Joseph M.; Shemansky, D. E.; Pryor, Wayne R. et al

in Icarus: International Journal of Solar System Studies (2001), 152(1), 151-171

The Galileo Extreme Ultraviolet Spectrometer (EUVS) and the Hopkins Ultraviolet Telescope (HUT) acquired UV spectra of Jupiter Aurora in the period from 1995 through 1997, The EUVS spectra spanned the ... [more ▼]

The Galileo Extreme Ultraviolet Spectrometer (EUVS) and the Hopkins Ultraviolet Telescope (HUT) acquired UV spectra of Jupiter Aurora in the period from 1995 through 1997, The EUVS spectra spanned the wavelength range 540-1280 Angstrom and the HUT spectra measured the extreme ultraviolet and far ultraviolet (EUV + FUV) wavelength range 830-1850 Angstrom. Both sets of spectra present evidence of high-altitude, optically thin H-2 band emissions from the exobase region, The analysis of the UV spectra with a two-stream electron transport model and a jovian model auroral atmosphere indicates that the primary electron flux is composed of both soft and hard electrons with characteristic energies in the soft electron energy range of 20-200 eV and the hard electron range of 5-100 keV, The soft electron flux causes enhanced EUV emission intensities below 1100 Angstrom. The soft electron flux may explain the high temperature of the upper atmosphere above the homopause as measured from Il: rovibrational temperatures in the IR. For the deep aurora, a high primary characteristic energy above 5 keV is known to be present. The Galileo Energetic Particle Detector (EPD) has measured the electron distribution functions for energies above 15 keV in the middle magnetosphere. The high-energy distribution functions can be modeled by a combination of Maxwellian and kappa distributions. However, the EUV (800-1200 Angstrom) portion of the HUT spectrum cannot be modeled with a single distribution of hard electrons as was possible in the past for the FUV (1200-1650 Angstrom) spectrum measured by itself, The combination of EUV and FUV spectral observations by HUT serves to identify the amount of soft electron flux relative to the hard primary flux required to produce the high-altitude aurora in the neighborhood of the exobase, (C) tool academic Press. [less ▲]

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See detailActualites therapeutiques 2001.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(9), 612-24

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule as well as its modalities of appropriate use in clinical practice will be pointed out. [less ▲]

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See detailla fièvre aphteuse : rappels épidémiologiques et cliniques
Thiry, Etienne ULg

in Point Vétérinaire (2001), 32

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See detailL'impact de la readaptation cardiaque sur la qualite de vie apres un pontage aorto-coronaire : Une etude belge
Etienne, Anne-Marie ULg; Fontaine, Ovide ULg; Dupuis, Gilles et al

in Revue Francophone de Clinique Comportementale et Cognitive (2001), 6(2), 15-25

The aim of this study was to measure the quality of life of coronary artery bypass surgery patients enrolled or not in a rehabilitation program. The study was prospective and longitudinal and used ... [more ▼]

The aim of this study was to measure the quality of life of coronary artery bypass surgery patients enrolled or not in a rehabilitation program. The study was prospective and longitudinal and used patients’ self selection as the allocation strategy to constitute the two groups: rehabilitation and no-rehabilitation. Forty first coronary bypass surgery patients (38 men and 2 women, mean age 59 +/-8) were recruited from four hospitals in a French area of Belgium. Patients were evaluated before and after surgery with: the Quality of Life Systemic Inventory (QLSI), the Beck Depression Inventory, the State Anxiety Inventory, a somatic symptoms questionnaire, a physical activities questionnaire, and a medical questionnaire. Both groups improved on the QLSI global score of quality of life, but the effect size (eta squared) was greater in the rehab group (0.5) compared to the no rehab group (0.25) [less ▲]

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See detailEpidémiologie moléculaire de la fièvre aphteuse
Thiry, Etienne ULg; Baranowski, Eric; Domingo, E.

in Epidémiologie et Santé Animale (2001), 39(59-67),

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See detailIntroduction générale aux techniques d'imagerie
Pirard, Eric ULg

in Techniques de l'Industrie Minérale (2001), 12

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See detailPharma clinics. Le medicament du mois. Le clopidogrel (Plavix).
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(3), 186-9

Clopidogrel is launched in Belgium by Sanofi-Synthelabo and Bristol-Myers Squibb under the trade name of Plavix. It is a potent and irreversible ADP receptor antagonist that proved to be more effective ... [more ▼]

Clopidogrel is launched in Belgium by Sanofi-Synthelabo and Bristol-Myers Squibb under the trade name of Plavix. It is a potent and irreversible ADP receptor antagonist that proved to be more effective than aspirin as antiplatelet agent in the multicentre, randomised double-blind CAPRIE study. It is indicated, at a dosage of 75 mg/day, for the reduction of atherosclerotic events including myocardial infarction, ischaemic stroke and vascular death in patients with atherosclerosis manifested by recent stroke, myocardial infarction or established peripheral vascular disease. Furthermore, recent studies demonstrated that the combination of clopidogrel with aspirin is more effective than aspirin alone and better tolerated than the combination ticlopidine-aspirin for the prevention of atherothrombosis after placement of intravascular stents. Ongoing trials are evaluating the efficacy and safety of such clopidogrel-aspirin combination after acute ischaemic coronary events or in patients at very high risk of stroke. Thus the indications of clopidogrel may become even larger in a next future. [less ▲]

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See detailLe dispositif d'évaluation externe en Communauté française de Belgique
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 195-218

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See detailLa recombinaison chez les alphaherpèsvirus
Meurens, François; Schynts, Frédéric; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (2001), 145

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