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See detailA control strategy for controllable series capacitor in electric power systems
Ghandhari, Mehrdad; Andersson, Goran; Pavella, Mania ULg et al

in Automatica (2001), 37

It has been veri"ed that a controllable series capacitor with a suitable control scheme can improve transient stability and help to damp electromechanical oscillations. A question of great importance is ... [more ▼]

It has been veri"ed that a controllable series capacitor with a suitable control scheme can improve transient stability and help to damp electromechanical oscillations. A question of great importance is the selection of the input signals and a control strategy for this device in order to damp power oscillations in an e!ective and robust manner. Based on Lyapunov theory a control strategy for damping of electromechanical power oscillations in a multi-machine power system is derived. Lyapunov theory deals with dynamical systems without inputs. For this reason, it has traditionally been applied only to closed-loop control systems, that is, systems for which the input has been eliminated through the substitution of a predetermined feedback control. However, in this paper, we use Lyapunov function candidates in feedback design itself by making the Lyapunov derivative negative when choosing the control. This control strategy is called control Lyapunov function for systems with control inputs. Also, two input signals for this control strategy are used. The "rst one is based on local information and the second one on remote information derived by the single machine equivalent method. [less ▲]

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See detailPropofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography study.
Bonhomme, Vincent ULg; Fiset, P.; Meuret, P. et al

in Journal of Neurophysiology (2001), 85(3), 1299-308

We investigated the effects of the general anesthetic agent propofol on cerebral structures involved in the processing of vibrotactile information. Using positron emission tomography (PET) and the H(2)(15 ... [more ▼]

We investigated the effects of the general anesthetic agent propofol on cerebral structures involved in the processing of vibrotactile information. Using positron emission tomography (PET) and the H(2)(15)O bolus technique, we measured regional distribution of cerebral blood flow (CBF) in eight healthy human volunteers. They were scanned under five different levels of propofol anesthesia. Using a computer-controlled infusion, the following plasma levels of propofol were targeted: Level W (Waking, 0 microg/ml), Level 1 (0.5 microg/ml), Level 2 (1.5 microg/ml), Level 3 (3.5 microg/ml), and Level R (Recovery). At each level of anesthesia, two 3-min scans were acquired with vibrotactile stimulation of the right forearm either on or off. The level of consciousness was evaluated before each scan by the response of the subject to a verbal command. At Level W, all volunteers were fully awake. They reported being slightly drowsy at Level 1, they had a slurred speech and slow response at Level 2, and they were not responding at all at Level 3. The following variations in regional CBF (rCBF) were observed. During the waking state (Level W), vibrotactile stimulation induced a significant rCBF increase in the left thalamus and in several cortical regions, including the left primary somatosensory cortex and the left and right secondary somatosensory cortex. During anesthesia, propofol reduced in a dose-dependent manner rCBF in the thalamus as well as in a number of visual, parietal, and prefrontal cortical regions. At Level 1 through 3, propofol also suppressed vibration-induced increases in rCBF in the primary and secondary somatosensory cortex, whereas the thalamic rCBF response was abolished only at Level 3, when volunteers lost consciousness. We conclude that propofol interferes with the processing of vibrotactile information first at the level of the cortex before attenuating its transfer through the thalamus. [less ▲]

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See detailEugène Monseur (1860-1912)
Boutier, Marie-Guy ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2001), (1),

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See detailEntre symbolisme et avant-garde : le modernisme de Franz Hellens dans la première série du Disque Vert (1921-1925)
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2001), (20), 66-75

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See detailQuelle réparation de l'accident de travail mortel est-elle réservée au concubin? Une réponse attendue de la Cour d'Arbitrage.
Michiels, Olivier ULg; Joskin, Véronique

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

Cette note aborde la quesiton suivante : L'article 12 de la loi du 12 avril 1971 relative aux accidents du travail viole-t-il les articles 10 et 11 de la Constitution en ce qu'il réserve le bénéfice d'une ... [more ▼]

Cette note aborde la quesiton suivante : L'article 12 de la loi du 12 avril 1971 relative aux accidents du travail viole-t-il les articles 10 et 11 de la Constitution en ce qu'il réserve le bénéfice d'une rente viagère au conjoint ni divorcé, ni séparé de corps ainsi qu'au conjoint divorcé ou séparé de corps qui bénéficiait d'une pension alimentaire à charge de la victime ? [less ▲]

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See detailNumerical modelling of coupled transient phenomena
Charlier, Robert ULg; Radu, Jean-Pol ULg; Collin, Frédéric ULg

in Revue Française de Génie Civil (2001), 5(6), 719-743

The basic phenomena involved in thermo-hydro-mechanical processes in geomaterials have been described in the 1st chapter. The equations describing these phenomena are non-linear differential equations ... [more ▼]

The basic phenomena involved in thermo-hydro-mechanical processes in geomaterials have been described in the 1st chapter. The equations describing these phenomena are non-linear differential equations. Their solution can generally only be approximated thanks to numerical methods. This is the main subject of the present chapter. First the type of problems and the set of equations to be solved will be shortly recalled. Emphasis will be given on the non-linear contributions. In a second section, the mostly developed numerical method, i.e. the finite difference and the finite element methods will be discussed under the light of the problems to be treated. The iterative techniques allowing the solution of non linear equations will be described. A third section will be dedicated to the coupling terms and to their modelling. The question that rises then is How to model efficiently problems, which may differ highly from, the point of view of the time and length scales? [less ▲]

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See detailImproving the bias/variance tradeoff of decision trees - towards soft tree induction
Geurts, Pierre ULg; Olaru, Cristina; Wehenkel, Louis ULg

in Engineering intelligent systems (2001), 9

One of the main difficulties with standard top down induction of decision trees comes from the high variance of these methods. High variance means that, for a given problem and sample size, the resulting ... [more ▼]

One of the main difficulties with standard top down induction of decision trees comes from the high variance of these methods. High variance means that, for a given problem and sample size, the resulting tree is strongly dependent on the random nature of the particular sample used for training. Consequently, these algorithms tend to be suboptimal in terms of accuracy and interpretability. This paper analyses this problem in depth and proposes a new method, relying on threshold softening, able to significantly improve the bias/variance tradeoff of decision trees. The algorithm is validated on a number of benchmark problems and its relationship with fuzzy decision tree induction is discussed. This sheds some light on the success of fuzzy decision tree induction and improves our understanding of machine learning, in general. [less ▲]

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See detailCaractérisation et valorisation du savoir paysan sur les insectes nuisibles du pois cajan (Cajanus cajan (L.) Millsp.) dans le Nord de l'Ouganda
Velay, F.; Baudoin, Jean-Pierre ULg; Mergeai, Guy ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(2), 105-114

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See detailValue of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase III trial.
Millot, F; Suciu, S; Philippe, N et al

in Journal of Clinical Oncology (2001), 19

PURPOSE: The European Organization for Research and Treatment of Cancer 58881 study was designed to test in a prospective multicentric randomized trial the value of high-dose (HD) intravenous (IV ... [more ▼]

PURPOSE: The European Organization for Research and Treatment of Cancer 58881 study was designed to test in a prospective multicentric randomized trial the value of high-dose (HD) intravenous (IV) cytarabine (Ara-C) added to HD IV methotrexate (MTX) to reduce the incidence of CNS and systemic relapses in children with increased-risk acute lymphoblastic leukemia (ALL) or stage III and IV lymphoblastic lymphoma treated with a Berlin-Frankfurt-Munster (BFM)-based regimen. PATIENTS AND METHODS: After completion of induction-consolidation phase, children with increased-risk (risk factor > 0.8 or T-lineage) ALL or stage III and IV lymphoblastic lymphoma were randomized to receive four courses of HD MTX (5 g/m(2) over 24 hours every 2 weeks) and four intrathecal administrations of MTX (Arm A) or the same treatment schedule with additional HD IV Ara-C (1 g/m(2) in bolus injection 12 and 24 hours after the start of each MTX infusion) (Arm B). RESULTS: Between January 1990 and January 1996, 653 patients with ALL (593 patients) or lymphoblastic lymphoma (60 patients) were randomized: 323 were assigned to Arm A (without Ara-C) and 330 to Arm B (with Ara-C). A total of 190 events (177 relapses and 13 deaths without relapse) were reported, and the median follow up was 6.5 years (range, 2 to 10 years). The incidence rates of CNS relapse were similar in both arms whether isolated (5.6% and 3.3%, respectively) or combined (5.3% and 4.6%, respectively). The estimated 6-year disease-free survival (DFS) rate was similar (log-rank P =.67) in the two treatment groups: 70.4% (SE = 2.6%) in Arm A and 71.0% (SE = 2.5%) in Arm B. The 6-year DFS rate was similar for ALL and LL patients: 70.2% (SE = 1.9%) versus 76.3% (SE = 5.6%). CONCLUSION: Prevention of CNS relapse was satisfactorily achieved with HD IV MTX and intrathecal injections of MTX in children with increased-risk ALL or stage III and IV lymphoblastic lymphoma treated with our BFM-based treatment protocol in which cranial irradiation was omitted. Disappointingly, with the dose schedule used in this protocol, HD Ara-C added to HD MTX, although well tolerated, failed to further decrease the incidence of CNS relapse or to improve the overall DFS. [less ▲]

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See detailAn On-line Glossary as a way to foster the construction of a common culture among urban experts, stakeholders and decision-makers
Teller, Jacques ULg

in Construction Innovation (2001), 1/4

Negotiation and public participation are a key aspect of present urban development projects. Argumentation support tools, based on the Toulmin logic, have often been presented as a way to increase the ... [more ▼]

Negotiation and public participation are a key aspect of present urban development projects. Argumentation support tools, based on the Toulmin logic, have often been presented as a way to increase the accountability of the debates between the different urban actors. It should still be assumed that any collaborative decision making requires some common culture to make the dialogue possible and constructive. Such a common understanding of basic terms, references and methods is often missing in present-day urban disputes, especially when complex issues like cultural heritage are at stake. The present paper discusses the relevancy of Web Glossaries as a way to build up such a common culture among urban experts, stakeholders and decision-makers. [less ▲]

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See detailRole of interface deformations in Benard-Marangoni instability
Lebon, Georgy ULg; Dauby, Pierre ULg; Regnier, Vincent

in Acta Astronautica (2001), 48(5-12), 617-627

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See detailAnalyse sociologique de la gestion des services de police, pour une compréhension par le jeu autour des règles
Schoenaers, Frédéric ULg

in Gestion : Revue Internationale de Gestion (2001), 25(4), 45-55

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See detailSémiologie cardiaque dans l’espèce équine. 2- L’auscultation.
Amory, Hélène ULg

in Pratique Vétérinaire Equine (2001)

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See detailLocation and Phenotype of Proliferating T cells in Secondary Lymph Follicles
Hoshi, S.; Bouzahzah, F.; Mancini, I. et al

in Journal of Clinical and Experimental Hematopathology [=JCEH] (2001), 42

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See detailThe Immuno-Inflammatory Reaction in Crohn's Disease and Ulcerative Colitis: Characterisation, Genetics and Clinical Application. Focus on Tnf Alpha
Louis, Edouard ULg

in Acta Gastro-Enterologica Belgica (2001), 64(1), 1-5

Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-inflammatory reaction, on genetic predisposition and on potential ... [more ▼]

Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-inflammatory reaction, on genetic predisposition and on potential clinical application of blood immuno-inflammatory markers in these diseases. This paper summarizes some aspects of this work, focusing on TNF. Following points are developed: production of TNF by inflamed mucosa, genetic control of TNF production, TNF gene polymorphim in inflammatory bowel disease, and evaluation of serum TNF as a marker of disease activity or evolutivity. [less ▲]

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See detailModelling and design of an electrostatically levitated disc for inertial sensing applications
Kraft, Michael ULg; Farooqui, Mateen M.; Evans, Alan G. R.

in Journal of Micromechanics and Microengineering (2001), 11(4), 423--427

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See detailGenetics of menopause-associated diseases.
Massart, François ULg; REGINSTER, Jean-Yves ULg; Brandi, M L

in Maturitas (2001), 40(2), 103-16

Menopause is the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. It is estimated that perhaps 50 million women worldwide will go into menopause annually ... [more ▼]

Menopause is the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. It is estimated that perhaps 50 million women worldwide will go into menopause annually. Atherosclerotic cardiovascular disease, osteoporotic fractures and Alzheimer's dementia are common chronic disorders after menopause, representing major health problems in most developed countries. Apart from being influenced by environmental factors, these chronic disorders recognize a strong genetic component, and there are now considerable clinic evidences that these disorders are related to low hormonal milieu of postmenopausal women. Here, we review up-to-date available data suggesting that genetic variation may contribute to higher susceptibility to four sporadic chronic syndromes such as osteoporosis (OP), osteoarthritis (OA), Alzheimer's disease (AD) and coronary artery disease (CAD). For these four syndromes candidate genes that today appear as major loci in genetic susceptibility encode for proteins specific of a given system, as the vitamin D receptor (VDR) gene for the skeleton and, therefore, OP or angiotensin converting enzyme (ACE) for the cardiovascular system and, therefore, CAD. The investigation of gene polymorphisms in various pathological conditions typical of postmenopause offer an explanation not only of their genetic inheritance but also of their co-segregation in given individuals. In this view, it may be possible to identify a common set of genes whose variants contribute to a common genetic background for these different disorders. Ideal candidates appear genes of the estrogen response cascade [i.e. estrogen receptor (ERs), enzymes involved in estrogen metabolism or co-activators and co-inhibitors]. All together this information may represent the basis both for future recognition of individuals at risk and for the pharmacogenetic driving of drug responsiveness. [less ▲]

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See detailThe Syntrichia Ruralis Complex In Belgium
Vanderpoorten, Alain ULg

in Cryptogamie Bryologie (2001), 22(2),

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See detailLe pilotage des systèmes d'enseignement
de Landsheere, Gilbert ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (5-6), 115-120

Un peu moins de trois ans après le congrès 'La Wallonie au futur. Le défi de l'éducation' (Namur, octobre 1991), Gilbert de Landsheere reprend la parole lors de l'introduction d'une conférence-consensus ... [more ▼]

Un peu moins de trois ans après le congrès 'La Wallonie au futur. Le défi de l'éducation' (Namur, octobre 1991), Gilbert de Landsheere reprend la parole lors de l'introduction d'une conférence-consensus (Namur, mars 1994) sur le thème 'Où en est et où va le système éducatif en Wallonie? Comment le savoir ?'. Il y est plus inquiet et en colère que jamais... et il le fait savoir ! Il poursuit la réflexion qu'il avait livrée dans deux des textes que nous publions également dans ces Cahiers ('L'avenir de l'enseignement' et 'Propositions relatives à l'enseignement'). Il expose aussi la substance de l'ouvrage qu'il fera publié chez De Boeck la même année. [less ▲]

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See detailLife-cycle modelling of bequests and its implications for annuity valuation
Jousten, Alain ULg

in Journal of Public Economics (2001), 79

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes ... [more ▼]

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes.We find that consumption is non-increasing in the linear bequest parameter for the simplest certainty case, but that the same is not true for life-span uncertainty. Second, we study the issue of annuity valuation. For a sufficiently strong bequest motive, the true value of an annuity is equal to the actuarial value. This invalidates a previous claim that, for imperfect annuity markets, it is close to the simple financial value. [less ▲]

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See detailA Parametric Distance Function Approach for Malmquist Productivity Index Estimation
Fuentes, Hugo J.; Grifell-Tatjé, Emili; Perelman, Sergio ULg

in Journal of Productivity Analysis (2001), 15

Malmquist indexes of productivity are generally estimated using index number techniques or non-parametric frontier approaches. The aim of this paper is to showthat Malmquist indexes can be estimated in a ... [more ▼]

Malmquist indexes of productivity are generally estimated using index number techniques or non-parametric frontier approaches. The aim of this paper is to showthat Malmquist indexes can be estimated in a similar way using parametric-deterministic or parametric-stochastic frontier approaches. To allow a multi-output multi-input technology and for technical change in production, we adopt an output distance function which is specified in a translog form. We then show that using the estimated parameters, several radial distance functions can be calculated and combined in order to estimate and decompose the productivity index. Finally, this approach is applied to a panel of Spanish insurance companies. The main results confirm those generally obtained for financial services: very low rates of growth and technical change in spite of a rapid deregulation process and expansion of activity. [less ▲]

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See detailAssociations between casein haplotypes and first lactation milk production traits in Finnish Ayrshire cows
Ikonen, T.; Bovenhuis, H.; Ojala, M. et al

in Journal of Dairy Science (2001), 84(2), 507-514

The objective of this study was to estimate the effects of ß--casein (CN) haplotypes on first-lactation milk production traits. The ß--CN haplotypes were deduced using information on ß- and -CN genotypes ... [more ▼]

The objective of this study was to estimate the effects of ß--casein (CN) haplotypes on first-lactation milk production traits. The ß--CN haplotypes were deduced using information on ß- and -CN genotypes of cows and their sires for 16,973 Finnish Ayrshire cows that had at least nine paternal half sibs. Effects of CN haplotypes on milk production traits were estimated for one haplotype at a time using an animal model, which included the fixed effects for calving year and month, age at calving, days open, ß-lactoglobulin, and a ß--CN haplotype. Differences in milk production traits were also estimated between haplotype combinations A1A+A2B and A1B+A2A within ß--CN genotype A1A2AB and between combinations A1E+A2A and A1A+A2E within genotype A1A2AE. The ß--CN haplotypes A2A and A2B were associated with high milk and protein yields and low fat content, and those that included the ß-CN A1 allele were associated with low yields and high fat content. Protein content was affected by the -CN locus; haplotype A1B was associated with high protein content and A1E was with low protein content. The haplotype combination A1A+A2B was associated with 140 kg more milk yield (P = 0.045) and 0.03 percentage units less protein content (P = 0.055) than combination A1B+A2A, and combination A1A+A2E showed 0.02 percentage units greater protein content (P = 0.098) than A1E+A2A. These results indicate that genes linked to the CN loci contribute to the variation in milk yield and protein content. [less ▲]

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See detailÉtude de l'influence de l'hydrodynamique sur une bactérie filamenteuse par analyse d'images
Groslambert, Sylvie ULg; Blacher, Silvia ULg; Crine, Michel ULg

in Récents Progrès en Génie des Procédés (2001), 78(18), 153-158

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See detailAn algorithm and a method to search bifurcation points in non-linear problems
Chambon, René; Crochepeyre, Stéphane; Charlier, Robert ULg

in International Journal for Numerical Methods in Engineering (2001), 51(3), 315-332

This paper is devoted to a numerical method able to help the determination of the bifurcation threshold in non-linear time-independent continuum mechanic problems. First, some theoretical results about ... [more ▼]

This paper is devoted to a numerical method able to help the determination of the bifurcation threshold in non-linear time-independent continuum mechanic problems. First, some theoretical results about uniqueness are recalled. In the framework of the large-strain assumption, the differences between the classical finite-step problem and the rate problem are presented. An iterative algorithm able to solve the rate problem is given. Using different initializations, it is seen in some numerical experiments that it is possible with this algorithm to get different solutions when the underlying mathematical problem solved does not enjoy a uniqueness property. The constitutive equations used have been chosen to be simple enough to deduce some theoretical knowledge about the corresponding uniqueness problems. Finally, a method is given which is able in some case to give an upper bound of the bifurcation threshold. Copyright (C) 2001 John Wiley & Sons, Ltd. [less ▲]

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See detailPreparation of mebendazole HP-beta-cyclodextrin complexes using water-soluble polymers and organic acids
Alvarez, Covadonga; Van Hees, Thierry ULg; Piel, Géraldine ULg et al

in STP Pharma Sciences (2001), 11(6), 439-442

Mebendazole (MBZ) is a carbamate derivative with an aminobenzimidazole structure. It possesses antihelminthic properties and is particularly insoluble in water. In order to increase its aqueous solubility ... [more ▼]

Mebendazole (MBZ) is a carbamate derivative with an aminobenzimidazole structure. It possesses antihelminthic properties and is particularly insoluble in water. In order to increase its aqueous solubility, hydroxpropyl-beta-cyclodextrin (HP-beta-CD) was used in combination with water-soluble polymers (polyvinylpyrrolidone or hydroxypropymethyl cellulose) and different organic acids (citric or tartaric). Increased solubility was observed on heating the mixture. The effects of the time and temperature of the heating process on drug solubility and stability were investigated. The results clearly show that the best conditions for increasing solubility and limiting degradation of MBZ is to heat a combination of MBZ, HP-beta-CD (200 mM), tartaric or citric acid (50 mM) and HPMC (0.1% w/v) in a water-bath at 95degreesC for 60 min. This method increases solubility to about 680 mug/ml and limits degradation to 2.5%. [less ▲]

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See detailDie endoluminale, kardiovaskuläre Radiotherapie:ein neuer Standard
Coucke, Philippe ULg; Ciernik, I-F

in Praxis (2001), 90

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of ... [more ▼]

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of coronary stenting further reducing cardiac morbidity. However, the incidence of restenosis after cardiovascular angioplasty remains high. The restenosis process is mainly explained by neo-intimal proliferation. Therefore, the utility of ionizing radiation has been systematically investigated in order to reduce proliferation of the neointimal tissue. Radiation therapy turns out to be a very efficient approach in reducing the rate of both de novo lesions as well as of instant restenosis. Recent clinical data from randomized trials confirm the utility of intracoronary radiation therapy and change the treatment standards in interventional cardiology. [less ▲]

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See detailThe effect of food on growth and metamorphosis of paedomorphs in Triturus alpestris apuanus
Denoël, Mathieu ULg; Poncin, Pascal ULg

in Archiv für Hydrobiologie (2001), 152(4), 661-670

The effect of food level on growth and metamorphosis of paedomorphs was examined in an experimental replicated design in Triturus alpestris apuanus. Paedomorphosis concerns the retention of larval ... [more ▼]

The effect of food level on growth and metamorphosis of paedomorphs was examined in an experimental replicated design in Triturus alpestris apuanus. Paedomorphosis concerns the retention of larval characteristics in adult individuals. Newts that forgo metamorphosis and then retain gill and gill slits in the adult stage maintain an aquatic life but keep potential for undergoing metamorphosis. Paedomorphs metamorphosed later in treatments with food as a non-limiting factor than in stressful treatments where food was limited. Timing of metamorphosis did not differ between males and females. Food level greatly affected growth rates. These results confirm and extend optimality models that predict paedomorphosis under advantageous aquatic conditions (paedomorph advantage hypothesis) and metamorphosis in stressful aquatic habitats. [less ▲]

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See detailProfils de la progestérone des vaches zébu ‘Azawak’ et taurin ‘Gourunsi’ après induction de l’œstrus aux progestagènes combinés à la prostaglandine
Zongo, M.; Pitala, W.; Boly, H. et al

in Tropicultura (2001), 19(3), 131-134

Un dosage radioimmunologique a été utilisé pour mesurer les concentrations de progestérone chez les zébus “Azawak” (Bos indicus, n = 6) et taurins Gourunsi (Bos taurus, n = 5) après induction de l'œstrus ... [more ▼]

Un dosage radioimmunologique a été utilisé pour mesurer les concentrations de progestérone chez les zébus “Azawak” (Bos indicus, n = 6) et taurins Gourunsi (Bos taurus, n = 5) après induction de l'œstrus. Les observations ont été menées sur 11 vaches non gestantes (groupe I composé de 3 zébus Azawak et 3 taurins Gourunsi; groupe II composé de 3 zébus Azawak et 2 taurins Gourunsi), soumises à un traitement hormonal reposant sur l’administration d’un implant de progestagène, d’une injection de prostaglandine F2alpha et, pour une partie des femelles (groupe I), d’une injection de PMSG. Les implants ont été placés sous la peau de la face externe de l’oreille et maintenus pendant une période de 10 jours. Au 8e jour du traitement, les femelles ont reçu une injection intramusculaire de prostaglandine F2 (5 mg/100 kg) et au 10e jour, au moment du retrait, une injection de PMSG (400 UI/300 kg de poids vif) a été pratiquée sur les animaux du groupe I. Chez les taurins Gourunsi et chez les zébus Azawak ayant reçu l’injection de PMSG, le traitement a été suivi d’un œstrus dans 2 cas sur 3. Chez les animaux appartenant au groupe II, l’œstrus ne fut observé chez aucun taurin et seulement chez 1 des 3 zébus. Les concentrations de progestérone mesurées au cours des phases lutéales qui ont suivi sont restées faibles chez les taurins Gourunsi. Chez les zébus Azawak, les concentrations se sont révélées plus élévées chez les femelles ayant reçu l’injection de PMSG (6,0 +/- 1,2 ng/ml) que chez celles qui n’avaient pas reçu (3,2 +/- 0,8 ng/ml). [less ▲]

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See detail«Lo sconosciuto Panegirico in lode di Carlo II di Gregorio Leti (ms. Liège, Université, W. 77)»
Moreno, Paola ULg

in Studi e Problemi di Critica Testuale (2001), LXI

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See detailMonitoring biologique des greffes de cellules souches hématopoïétiques
GOTHOT, André ULg

in Focus Diagnostica (2001), 9

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See detailIdentification of Brucella spp. genes involved in intracellular trafficking.
Delrue, R. M.; Martinez-Lorenzo, M.; Lestrate, P. et al

in Cellular Microbiology (2001), 3(7), 487-97

After uptake by host cells, the pathogen Brucella transits through early endosomes, evades phago-lysosome fusion and replicates in a compartment associated with the endoplasmic reticulum (ER). The ... [more ▼]

After uptake by host cells, the pathogen Brucella transits through early endosomes, evades phago-lysosome fusion and replicates in a compartment associated with the endoplasmic reticulum (ER). The molecular mechanisms underlying these processes are still poorly understood. To identify new bacterial factors involved in these processes, a library of 1800 Brucella melitensis 16M mini-Tn5catkm mutants was screened for intracellular survival and multiplication in HeLa cells and J774A.1 macrophages. Thirteen mutants were identified as defective for their intracellular survival in both cell types. In 12 of them, the transposon had inserted in the virB operon, which encodes a type IV-related secretion system. The preponderance of virB mutants demonstrates the importance of this secretion apparatus in the intracellular multiplication of B. melitensis. We also examined the intracellular fate of three virB mutants (virB2, virB4 and virB9) in HeLa cells by immunofluorescence. The three VirB proteins are not necessary for penetration and the inhibition of phago-lysosomal fusion within non-professional phagocytes. Rather, the virB mutants are unable to reach the replicative niche and reside in a membrane-bound vacuole expressing the late endosomal marker, LAMP1, and the sec61beta protein from the ER membrane, proteins that are present in autophagic vesicles originating from the ER. [less ▲]

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See detailEffets benefiques de l'activite physique sur les facteurs de risque cardio-vasculaire.
Scheen, André ULg; Paquot, Nicolas ULg

in Revue Médicale de Liège (2001), 56(4), 239-43

Numerous observational (epidemiological surveys) or interventional (controlled trials) studies demonstrated that regular physical activity increases insulin sensitivity in normal subjects and decreases ... [more ▼]

Numerous observational (epidemiological surveys) or interventional (controlled trials) studies demonstrated that regular physical activity increases insulin sensitivity in normal subjects and decreases insulin resistance in patients with obesity and/or type 2 diabetes. These favourable effects are at least partially linked to a reduction in abdominal fat mass. This results in a significant improvement of lipid profile, with a decrease in the concentrations of total cholesterol, LDL cholesterol and triglycerides, associated with an increase of HDL cholesterol level. Such favourable metabolic effects related to regular physical activity probably explain the better cardiovascular prognosis observed in regularly exercising subjects as compared to sedentary individuals. These observations should motivate any practitioner to promote endurance physical exercise in every subject, especially in individuals at high cardiovascular risk. [less ▲]

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See detailAspidothelium gemmiferum sp. nov., from Papua new Guinea (Lichenized Ascomycetes)
Sérusiaux, Emmanuël ULg; Lücking, Robert

in Mycotaxon (2001), 79

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See detailOral vitamin C attenuates acute ischaemia-reperfusion injury in skeletal muscle.
Kearns, S. R.; Moneley, D.; Murray, P. et al

in Journal of Bone & Joint Surgery, British Volume (2001), 83(8), 1202-6

Ischaemia-reperfusion injury (IRI) is caused by endothelial and subendothelial damage by neutrophil-derived oxidants. Vitamin C is an antioxidant which attenuates endothelial injury after IRI. Our aim was ... [more ▼]

Ischaemia-reperfusion injury (IRI) is caused by endothelial and subendothelial damage by neutrophil-derived oxidants. Vitamin C is an antioxidant which attenuates endothelial injury after IRI. Our aim was to evaluate the effect of oral vitamin C in the prevention of IRI in skeletal muscle. We used a model of cross-clamping (3 hours) and reperfusion (1 hour) of the cremaster muscle in rats. Muscle function was assessed electrophysiologically by electrical field stimulation. Infiltration by neutrophils was determined by the activity of tissue myeloperoxidase (MPO) and tissue oedema by the wet-to-dry ratio. Neutrophil respiratory burst activity was measured in control animals and groups pretreated with vitamin C. IRI significantly decreased muscle function and increased muscle neutrophil MPO activity and muscle oedema. Pretreatment with vitamin C preserved muscle function and reduced tissue oedema and neutrophil infiltration. Neutrophil respiratory burst activity was reduced in the group treated with vitamin C compared with the control group. We conclude that pretreatment with oral vitamin C protects against acute muscle IRI, possibly by attenuating neutrophil respiratory burst activity. [less ▲]

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See detailN N scattering phase shifts in a chiral constituent quark model
Bartz, Daniel ULg; Stancu, Floarea ULg

in Nuclear Physics A (2001), A688

We study the nucleon-nucleon interaction within a chiral constituent quark model which reproduces succesfully the baryon spectra. We calculate the $^3S_1$ and $^1S_0$ phase shifts by using the resonating ... [more ▼]

We study the nucleon-nucleon interaction within a chiral constituent quark model which reproduces succesfully the baryon spectra. We calculate the $^3S_1$ and $^1S_0$ phase shifts by using the resonating group method. They clearly indicate the presence of a strong repulsive interaction at short distance, due to the spin-flavour symmetry of the quark-quark interaction and of the quark interchange between the two interacting nucleons. A $\sigma$-meson exchange quark-quark interaction, providing a medium-range attraction, helps to get closer to the experimental phase shifts. [less ▲]

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See detailShort-term variations of the partial pressure of CO2 in surface waters of the Galician upwelling system
Borges, Alberto ULg; Frankignoulle, Michel

in Progress in Oceanography (2001), 50(2-4), 283-302

The partial pressure of CO2 (pCO2) and dissolved oxygen saturation level (%O2) were monitored continuously during a cruise in August 1998, which sampled surface waters off the Galician coast. Data are ... [more ▼]

The partial pressure of CO2 (pCO2) and dissolved oxygen saturation level (%O2) were monitored continuously during a cruise in August 1998, which sampled surface waters off the Galician coast. Data are presented from two Lagrangian experiments carried out in an upwelling on the continental shelf and in the core of an offshore filament. The data show that daily variations in surface pCO2 and oxygen (%O2) were controlled by the diurnal cycle of primary production/respiration, temperature variations and air–sea exchange. Data obtained during various cross-shelf and cross-filament transects are also discussed and give an insight into the processes controlling large scale variations of pCO2 and %O2 in the Galician upwelling system. These data suggest that upwelling filaments are an important feature of the inorganic carbon cycle of upwelling systems. However more field data in the various eastern boundary current systems worldwide are needed. [less ▲]

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See detailGenesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies: the stochastic model revisited
Paulus, Jean-Michel ULg; Levin, Jack; Debili, Najet et al

in International Society for Experimental Hematology (2001), 29(nd), 1256-69

OBJECTIVE: We previously showed that the distributions of the numbers of doublings (NbD) undergone by individual megakaryocyte progenitors before commitment to polyploidization are markedly skewed and can ... [more ▼]

OBJECTIVE: We previously showed that the distributions of the numbers of doublings (NbD) undergone by individual megakaryocyte progenitors before commitment to polyploidization are markedly skewed and can consistently be fitted to straight lines when plotted on semilogarithmic coordinates. The slope of such lines, which yields the probability of polyploidization per doubling, is made less steep by stimulators of megakaryocyte colony formation and is less steep in mixed erythroid-megakaryocyte than in pure megakaryocyte colonies. Therefore, megakaryocytopoiesis provides a unique model for the study of clonal heterogeneity in a hemopoietic lineage, which is the subject of this review. DATA SOURCES: Articles relevant to the interpretation of these data were selected from the authors' and public databases. DATA SYNTHESIS: Exponential NbD distributions were first explained by postulating that following the assembly of thrombopoiesis-specific regulators, megakaryocyte progenitors require only a single random event to arrest proliferation and commit to polyploidization. However, this stochastic model was refuted by data indicating that intrinsic properties of individual progenitors affect the NbD they achieve. We suggest that the unequal repartition of critical compounds (including receptors, signaling molecules, and gene regulators) inherent in the stem cell-progenitor transition causes a heritable heterogeneity in megakaryocyte progenitor responsiveness to polyploidization inducers. This model would be compatible with 1) the evidence for intraclonal synchronization in megakaryocyte and other hemopoietic clones generated by committed progenitors; 2) the low probability of polyploidization of the relatively insensitive bipotent megakaryocyte progenitors; and 3) the thesis that stimulators act in part by recruiting megakaryocyte progenitor cells endowed with lesser responsiveness to polyploidization inducers and higher proliferative potential. CONCLUSION: The responsiveness of individual megakaryocyte progenitors to polyploidization inducers may be a major determinant of the exponential shape of NbD distributions. [less ▲]

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See detailMons/Maisières : le site de plein air de Maisières-Canal
Miller, Rebecca ULg; Otte, Marcel ULg; Haesaerts, Paul

in Chronique de l'Archéologie Wallonne (2001), 9

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See detailQuelle biodiversite pour nos lisieres forestieres?
Branquart, E.; Doucet, Jean-Louis ULg; Liesse, D. et al

in Parcs & Réserves (2001), 56(1), 26-32

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See detailTeloptosis, a Turning Point in Hair Shedding Biorhythms
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 203(2), 115-7

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from ... [more ▼]

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from teloptosis. Both events are triggered by distinct factors. Indeed, teloptosis is the result of the loss of adhesion between cells of the club hair and those of its epithelial envelope. Teloptosis synchronization is perceived as telogen effluvium, related or not to shortening of the anagen phase. Subtle changes leading to early or delayed teloptosis affect hair density. It is possible to distinguish two types of telogen hairs on a trichogram. Those with an epithelial sheath indicate strong binding, suggesting early telogen, whereas the absence of an epithelial sheath indicates loose binding, conveying teloptosis. [less ▲]

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See detailPlante-t-on l'épicéa n'importe où ? L'apport d'une analyse objective de la pessière wallonne.
Claessens, Hugues ULg; Lecomte, Hugues; Lejeune, Philippe ULg et al

in Forêt Wallonne (2001), (49-50), 45-51

Depuis son introduction dans la sylviculture belge au milieu du XIXe siècle, l'épicéa s'est progressivement imposé principalement grâce à sa bonne adaptation aux difficiles conditions écologiques de l ... [more ▼]

Depuis son introduction dans la sylviculture belge au milieu du XIXe siècle, l'épicéa s'est progressivement imposé principalement grâce à sa bonne adaptation aux difficiles conditions écologiques de l'Ardenne, la facilité de sa culture et sa haute productivité en sols pauvres. Il est devenu la première essence de la forêt wallonne où il représente près de la moitié du volume de bois sur pied. Mais petit à petit, l'impact négatif de sa culture à grande échelle sur l'environnement s'est aussi révélé, notamment lors de son introduction dans des milieux fragiles qu'il a altérés, voire détruits. Ces erreurs ont progressivement amené de plus en plus d'observateurs de notre patrimoine naturel à rejeter globalement l'épicéa et sa culture en Belgique. Ces cas malheureux sur lesquels se sont focalisées l'opinion publique et scientifique sont-ils l'exeption ? Dans quelle mesure l'épicéa a-t-il colonisé à tort certains milieux ? Dans quelles conditions sa culture est-elle acceptable, tolérée ou à exclure ? C'est à ce type de question que la présente étude tente de répondre. [less ▲]

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See detailLe transsexualisme et l'anorexie mentale : emprise et tyrannie de la subjectivité : approches méthodologiques
Mormont, Christian ULg; Frankignoul, A.; Michel, Aude

in Pratiques psychologiques (2001), (3), 25-36

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See detailHelping children to learn languages (Aider son enfant à apprendre les langues)
Blondin, Christiane ULg

in European Parents Association - Info Bulletin (2001), (Hiver 2001), 11-16

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See detailChronic rupture of abdominal aortic aneurysm manifesting as crural neuropathy.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; LAVIGNE, Jean-Paul ULg et al

in Annals of Vascular Surgery (2001), 15(3), 405-11

Chronic rupture of abdominal aortic aneurysm (AAA) resulting in unusual clinical manifestations can occur if the resistance of structures surrounding the aorta is sufficient to contain hemorrhage. In this ... [more ▼]

Chronic rupture of abdominal aortic aneurysm (AAA) resulting in unusual clinical manifestations can occur if the resistance of structures surrounding the aorta is sufficient to contain hemorrhage. In this report, we describe five cases of chronic ruptured AAA in which the presenting feature was crural neuropathy. All patients were male with a mean age of 74 +/- 1.8 years. At the time of presentation, crural neuropathy had been ongoing for 3 to 9 weeks. In three cases, AAA was not initially suspected because an inadequate clinical examination was performed (not in the vascular surgery department) and because of the small diameter of the aorta in relation to the patient's morphology. Two patients had one episode of hypotension that was wrongly attributed to vagal attack. Abdominal CT scanning was always diagnostic of chronic rupture. In two cases, rupture was associated with erosion of the body of one or more vertebrae and laboratory evidence of inflammation, i.e., increase in sedimentation rate and fibrinogen level. The mean diameter of the AAA was 7.1 +/- 0.9 cm (range 5-10 cm). All patients underwent midline laparotomy, which was performed under emergency conditions in two cases, under semi-emergency conditions in one case, and electively in two cases. Perforation was consistently located on the posterolateral wall of the aorta and varied from 1 to 3 cm in length. Repair was performed using an aortobifemoral prosthesis in four cases, and a straight tube in one case. The patient who underwent emergency surgery died 4 days after the procedure. The remaining four patients recovered uneventfully and were discharged after 10 days. In the elderly, ruptured AAA should be included in the differential diagnosis of crural neuropathy. An episode of hypotension, regardless of its duration, in an elderly patient should be given serious consideration as a possible sign of ruptured AAA with ongoing retroperitoneal hemorrhage. [less ▲]

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See detailUn exemple de gestion originale de la nature : la restauration de forêts alluviales de l’Elbe
Claessens, Hugues ULg

in Parcs & Réserves (2001), 56(1), 23-25

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See detailThe 'Aesthetics of Personalism' in Caryl Phillips's Writing: Complexity as a New Brand of Humanism
Ledent, Bénédicte ULg

in World Literature Written in English (2001), 39(1), 75-85

This paper attempts to underline the epistemological implications of Phillips's handling of diasporic history through a focus on individual lives in Cambridge (1991) and The Nature of Blood (1997). His ... [more ▼]

This paper attempts to underline the epistemological implications of Phillips's handling of diasporic history through a focus on individual lives in Cambridge (1991) and The Nature of Blood (1997). His confessional first-person narratives highlight the intricacies inherent in human nature, thereby resisting the globalizing discourse of liberal humanism. Even more importantly, his fictions seem to illustrate a new, more understanding approach to this often hackneyed term, for they give voice to individuals whose multiple differences are, paradoxically, part proof of a common humanity, viewed here as an inclusive rather than exclusive concept. [less ▲]

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See detailLes mélèzes
Rondeux, Jacques ULg; Pauwels, D.

in Fiche technique (2001)

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See detailSynthesis and optical properties of opal and inverse opal photonic crystals
Johnson, N. P.; McComb, D. W.; Richel, Aurore ULg et al

in Synthetic Metals (2001), 116(1-3), 469-473

We describe the synthesis of two complementary photonic crystals: opal and an inverted opal structure consisting of air spheres in a titania matrix. From optical measurements and comparison with the ... [more ▼]

We describe the synthesis of two complementary photonic crystals: opal and an inverted opal structure consisting of air spheres in a titania matrix. From optical measurements and comparison with the literature, the mechanical strength and effective refractive index are increased by sintering for opal and because of compression for the inverse opal. However, this is at the expense of reducing the PBG in the [1 1 1] direction. [less ▲]

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See detailA comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatment of patients with osteoarthritis of the lumbar spine.
Valat, J P; Accardo, S; REGINSTER, Jean-Yves ULg et al

in Inflammation Research (2001), 50(Suppl 1), 30-4

OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine. SUBJECTS: 229 patients with ... [more ▼]

OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine. SUBJECTS: 229 patients with radiologically confirmed osteoarthritis of the lumbar spine. TREATMENT AND METHODS: Once-daily meloxicam 7.5 mg tablet or diclofenac 100 mg slow release tablet. Efficacy and tolerability parameters were assessed at baseline and after 3, 7 and 14 days of treatment. RESULTS: The two drugs had equal short-term efficacy, with pain on motion of lumbar spine significantly (p<0.05) decreased at Day 3. Secondary efficacy variables were also significantly improved at Days 3, 7 and 14. There were no statistically significant differences between the two drugs, although the global tolerability of meloxicam was significantly better than for diclofenac, as assessed by the investigators (p = 0.0072) and the patients (p = 0.049). CONCLUSIONS: Meloxicam and diclofenac were equivalent in relieving the acute pain associated with osteoarthritis of the lumbar spine. However, meloxicam was much better tolerated. [less ▲]

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See detailA propos du remplage de la verrière d'Esther.
Morard, Thomas ULg

in Arte Cristiana (2001), 89(802), 23-30

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See detailLe point sur le dépérissement de l’aulne
Claessens, Hugues ULg; Cavelier, Marc

in Forêt Wallonne (2001), 49/50

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See detailUn nouveau projet archéologique de l'Université de Lyon 2.
Morard, Thomas ULg; Wavelet, David

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2001), 113(1), 477-481

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See detailLes surcoûts de l’étalement urbain en Wallonie
Halleux, Jean-Marie ULg

in Etudes Foncières (2001), (94), 18-21

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See detailInfections virales humaines d'origine alimentaire
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Point Vétérinaire (2001), 218

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See detailThe use of additives to prepare low-density xerogels
Alié, Christelle ULg; Pirard, René ULg; Lecloux, A. J. et al

in Journal of Non-Crystalline Solids (2001), 285

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See detailTreatment of drug-induced toxic epidermal necrolysis (Lyell’s syndrome) with intravenous human immunoglobulins
Paquet, Philippe ULg; JACOB, Eric; Damas, Pierre ULg et al

in Burns : Journal of the International Society for Burn Injuries (2001), 27(6), 652-655

Toxic epidermal necrolysis (TEN) is a rare drug-induced life-threatening disease. Currently, the disease is only treated by supportive and antiseptic measures. Quite recently intravenous immunoglobulins ... [more ▼]

Toxic epidermal necrolysis (TEN) is a rare drug-induced life-threatening disease. Currently, the disease is only treated by supportive and antiseptic measures. Quite recently intravenous immunoglobulins (IG) were shown to be a promising TEN treatment. The rationale for their use is based on the fact that keratinocyte apoptosis in TEN involves the CD95 (APO-1/Fas) cell surface receptor–ligand system. We successfully treated a TEN patient with high dose of intravenous IG. The clinical recovery appeared exceptionally rapid. Immunohistochemistry showed that the IG action probably developed on the CD95 receptor–ligand system at the keratinocytes surface. [less ▲]

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See detailLow TSH requirement and goiter in transgenic mice overexpressing IGF-1 and IGF-1R in the thyroid gland
Clément, S.; Refetoff, S.; Robaye, B. et al

in Endocrinology (2001), 142(12), 5131-5139

Through the cAMP signaling pathway, TSH stimulates thyroid follicular cell proliferation, differentiation, and function. Although the autocrine production of IGF-I in the thyroid gland suggests an ... [more ▼]

Through the cAMP signaling pathway, TSH stimulates thyroid follicular cell proliferation, differentiation, and function. Although the autocrine production of IGF-I in the thyroid gland suggests an important physiological function for this factor in these processes, the exact role of the IGF-I/IGF-I receptor system in vivo remains unclear. Although the mitogenic action of TSH requires the presence of IGF-I or insulin in primary culture of dog and human thyroid cells, IGF-I has an effect equal to and independent of the effect of TSH on cell proliferation in rat thyroid cell lines and may even be the main growth regulator in this case. To investigate the in vivo function of the IGF-I/IGF-I receptor system, transgenic mice overexpressing human IGF-I, IGF-I receptor, or both in the thyroid were generated. Adult transgenic mice did not present external signs of thyroid dysfunction, but mice overexpressing both transgenes had significantly increased gland weight and follicular lumen area. A decreased TSH level together with a slightly increased serum T4 concentration and increased thyroidal iodine uptake were also observed, suggesting that IGF-I and IGF-I receptor stimulate thyroid function to some extent in vivo [less ▲]

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See detailLes devoirs : un canal de communication entre l’école et la famille ?
Poncelet, Débora; Schillings, Patricia ULg; Hindryckx, Geneviève ULg et al

in Point sur la Recherche en Education (Le) (2001), 20

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See detailSurface Modification of Polycarbonate and Poly(ethyleneterephthalate) Films and Membranes by Polyelectrolyte Deposition
Dauginet, Laurence; Duwez, Anne-Sophie ULg; Legras, Roger et al

in Langmuir (2001), 17

The surface modification by chemical or physical adsorption of a polyelectrolyte (polyallylamine, PAH) was established using hydrolyzed polycarbonate (PC) and poly(ethylene terephthalate) (PET) thick and ... [more ▼]

The surface modification by chemical or physical adsorption of a polyelectrolyte (polyallylamine, PAH) was established using hydrolyzed polycarbonate (PC) and poly(ethylene terephthalate) (PET) thick and thin films. Contact angle data indicated changes in the hydrophilicity of PET film surfaces in terms of the chemical treatment. XPS analysis showed that the immobilization of PAH on PET and PC films was effective and that the amount of chemically or/and physically bounded PAH depends on the pH of the electrolyte solution used for the adsorption. Similar treatments have been successfully applied to polymeric track-etched membranes. These modified membranes have been used as templates for the synthesis of polypyrrole (PPy) nanotubules. FE-SEM analysis showed that much thicker PPy tubules were obtained in modified membranes than in virgin ones. This indicates that the surface chemistry of the pore walls plays an important role in the morphology of the nanostructures synthesized within the pores [less ▲]

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See detailRole de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumorale
Bajou, Khalid ULg; Devy, L.; Masson, Véronique ULg et al

in Thérapie (2001), 56(5, Sep-Oct), 465-72

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen ... [more ▼]

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen activation system, and paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been correlated with a poor prognosis for patients with cancers of different types. Recent findings clearly suggest that PAI-1 is essential for capillary sprouting during tumour angiogenesis. Moreover, there is accumulating evidence that both the urokinase receptor and PAI-1 are multifunctional proteins involved not only in extracellular matrix proteolysis but also in cellular adhesion and migration through their binding site for vitronectin. The understanding of whether PAI-1 plays a regulatory role in angiogenesis by tightly controlling proteolytic activity or by influencing cell migration could allow a new anti-angiogenic approach for tumour therapy. [less ▲]

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See detailSize-related predation reduces intramorph competition in paedomorphic Alpine newts
Denoël, Mathieu ULg; Joly, Pierre

in Canadian Journal of Zoology (2001), 79(6), 943-948

Evolutionary theory assumes that facultative paedomorphosis in newts and salamanders is adaptive in allowing either a younger age at maturity or resource partitioning between the heterochronic morphs. In ... [more ▼]

Evolutionary theory assumes that facultative paedomorphosis in newts and salamanders is adaptive in allowing either a younger age at maturity or resource partitioning between the heterochronic morphs. In newt populations that only take the metamorphic ontogenetic pathway, juveniles are terrestrial and avoid food competition with larvae and breeding adults. In contrast, in populations where paedomorphosis occurs, branchiate newts of all sizes coexist in the aquatic habitats, posing the question of whether intramorph competition exists and its relationship with the evolution of paedomorphosis. We studied size-related predation in such a size-structured community of branchiate Alpine newts (Triturus alpestris) inhabiting a deep alpine lake. Although gape limitation may explain such size-related predation, individuals also exhibited selectivity according to prey size. Amongst small prey that were within the capture range of all newt size classes, smaller newts preyed on smaller items than did larger ones. We assume that such decisions favour the coexistence of different-sized individuals. It is suspected that such size-selective predation on items which are avoided by water-living metamorphs allows the maintenance of facultative paedomorphosis, in favouring resource partitioning between morphs. [less ▲]

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See detailGene structure and promoter function of a teleost ribosomal protein: a tilapia (Oreochromis mossambicus) L18 gene
Molina, Alfredo; Iyengar, Arati; Marins, Luis F. et al

in Biochimica et Biophysica Acta (2001), 1520(3), 195-202

We have cloned and characterized a tilapia (Oreochromis mossambicus) L18 ribosomal protein gene, including the complete transcribed region and 488 bp of upstream regulatory sequences. We have also ... [more ▼]

We have cloned and characterized a tilapia (Oreochromis mossambicus) L18 ribosomal protein gene, including the complete transcribed region and 488 bp of upstream regulatory sequences. We have also isolated two L18 cDNAs from another tilapia (Oreochromis niloticus) with a few conservative nucleotide differences. Our results suggest the presence of two genes in both species. Reporter constructs were tested for transient expression in CV1 cells and in microinjected zebrafish and tilapia embryos. The tilapia L18 promoter was able to drive expression of the reporter gene in all three experiments, with no apparent preference for a particular tissue. The tilapia L18 promoter is therefore likely to be a powerful tool to drive tissue-independent gene expression in fish. [less ▲]

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See detailÉvolution des accessibilités et des mobilités des localisations commerciales
Merenne-Schoumaker, Bernadette ULg

in Travaux de l’Institut de Géographie de Reims (2001), 27(107-108), 7-23

In order to be able to study the links between the evolution of accessibilities and mobilities and the dynamics of the commercial localizations, the article has been organized in three parts : firstly ... [more ▼]

In order to be able to study the links between the evolution of accessibilities and mobilities and the dynamics of the commercial localizations, the article has been organized in three parts : firstly, the definition of the concepts of accessibility and mobility as well as the distance; secondly, analysis of the role of these two concepts in the commercial field and the their most evident recent evolutions; lastly, research into corresponding links. On the basis of this work, everything indicates the priority of mobility over accessibility as well as very close relations between the mutations of urbanized territories and the installation of the new commercial framework, which is strongly governed by car mobility. [less ▲]

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See detailChromogenic detection of aminoglycoside phosphotransferases.
Amoroso, Ana Maria ULg; Gutkind, G. O.

in Methods in molecular medicine (2001), 48

Acquired resistance to aminoglycosides is most frequently due to the presence of the so-called aminoglycoside modifying enzymes (AGME) (1) able to catalyze one or more of three general reactions: N ... [more ▼]

Acquired resistance to aminoglycosides is most frequently due to the presence of the so-called aminoglycoside modifying enzymes (AGME) (1) able to catalyze one or more of three general reactions: N-acetylation, O-nucleotidylation and O-phosphorylation (2). Although resistance phenotype (to different (substrate or not for enzymatic modification) may serve as an approach for identifying actual enzymes present in a given isolate (3), results can be obscured or confusing, particularly when several different enzymes (4) (even, isoenzymes with different affinities) are superimposing their action in a single microorganism with potential "permeability" or target alterations. Thus, identification of the AGME content of a given strain also requires screening at the DNA level using probes specific to all the known AGME (5). However, the complete set of probes is available only to a few laboratories around the world, making surveillance for the appearance of novel enzymes, or the unlikely evolution of those already known, a relatively nonfeasible goal, as search for new enzymes may begin only after failing to hybridize to all known probes. [less ▲]

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See detailImage analysis, impedance spectroscopy and mercury porosimetry characterisation of freeze-drying porous materials
Blacher, Silvia ULg; Maquet, Véronique; Pirard, René ULg et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2001), 187-188

Image analysis and impedance spectroscopy have been used as potential tools for the characterization of the texture of ultramacroporous PLA foams prepared by freeze-drying. It has been shown that these ... [more ▼]

Image analysis and impedance spectroscopy have been used as potential tools for the characterization of the texture of ultramacroporous PLA foams prepared by freeze-drying. It has been shown that these two techniques actually provide valuable information on the structure of this material. They are complementary to mercury porosimetry, which does not allow morphological details to be distinguished. Image analysis of SEM micrographs of transverse cross-sections at two different magnifications gave information on both the macroporosity (1 μm < width < 10 μm) and ultramacroporosity (width > 10 μm). Impedance spectroscopy was used to investigate the transport properties of the three-dimensional porous matrices by measurement of ionic conduction [less ▲]

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See detailL'invention de la mélancolie. Note sur l'ancienneté de la photographie
Havelange, Carl ULg

in Journal Français de Psychiatrie. Clinique, Scientifique et Psychanalytique (2001), 16

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See detailInsecticide resistance gene transmission by insecticide-susceptible insects
Arnaud, Ludovic; Callaghan, Amanda; Haubruge, Eric ULg

in Functional Ecology (2001)

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See detailRisedronate Increases Bone Mineral Density and Reduces the Vertebral Fracture Incidence in Postmenopausal Women
Reginster, Jean-Yves ULg

in Clinical and Experimental Rheumatology (2001), 19(1), 121-2

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See detailLa lecture littéraire : le pour et le contre
Dumortier, Jean-Louis ULg

in Education-Formation (2001), 262

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See detailIntégration régionale et démocratie. Quelques réflexions à partir de la pensée d'Alexis de Tocqueville
Carlier, Jean-Yves ULg

in Revue Burkinabè du droit (2001), (39-40), 9-20

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See detailHIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.
Michiels, C.; Minet, E.; Michel, G. et al

in IUBMB Life (2001), 52(1-2), 49-53

HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the ... [more ▼]

HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively. [less ▲]

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See detailCatalytic asymmetric dihydroxylation of C,C double bonds with osmium tetroxide using selenoxides as co-oxidants
Krief, A.; Colaux, Catherine ULg

in Synlett (2001), (4), 501-504

Asymmetric dihydroxylation of olefins has been achieved in good yields and ee's using potassium osmate dihydrate (K2OsO2(OH)(4), the pre-oxidant), (DHQD)(2)PHAL (the chiral ligand), potassium carbonate ... [more ▼]

Asymmetric dihydroxylation of olefins has been achieved in good yields and ee's using potassium osmate dihydrate (K2OsO2(OH)(4), the pre-oxidant), (DHQD)(2)PHAL (the chiral ligand), potassium carbonate (the base) and selenoxides (the co-oxidants). Bath the yield and the ee proved to be pH dependent, the highest yield and ee being found at almost the same pH values. The rate of the reaction was found to be highly dependent upon the structure of the selenoxide used. Some representative examples involving aminoxides are presented for comparison. [less ▲]

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See detailComparison between the GIRBAS Scale and the Acoustic and Aerodynamic Measures Provided by EVA for the Assessment of Dysphonia following Unilateral Vocal Fold Paralysis.
Morsomme, Dominique ULg; Jamart, Jacques; Wery, Carine et al

in Folia Phoniatrica et Logopaedica (2001), 53(6), 317-25

The aim of this study is to establish relevant objective parameters for evaluating dysphonia following unilateral vocal fold paralysis. To do so, the study compares objective and perceptual voice measures ... [more ▼]

The aim of this study is to establish relevant objective parameters for evaluating dysphonia following unilateral vocal fold paralysis. To do so, the study compares objective and perceptual voice measures. The objective measures were obtained using a voice analysis software (Evaluation Vocale Assistee), whereas the perceptual measures were established with the GIRBAS Scale (grade, instability, roughness, breathiness, asthenia, and strain). All measurements were performed on 40 voice samples: 28 dysphonic subjects with unilateral laryngeal paralysis, and 12 control subjects. The intra- and inter-judge agreements were fairly good, at least for control subjects. The six GIRBAS measures obtained from the pathological voices were higher than those from the control voices (p < 0.001) and the correlation between both groups was good. Grade, breathiness and asthenia correlated with the objective parameters that express the aperiodicity of the phonatory signal (p < 0.01), namely, the coefficient of variability of the fundamental frequency, the coefficient of variability of intensity, and jitter. Our findings suggest that the perceptual reality of laryngeal paralysis-induced dysphonia depends more on grade, breathiness and asthenia than it does on roughness or instability. [less ▲]

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See detailSome properties of generalized age-distribution equations in fluid dynamics
Beckers, Jean-Marie ULg; Delhez, Eric ULg; Deleersnijder, Eric

in SIAM Journal on Applied Mathematics (2001), 61(5), 1526-1544

The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry ... [more ▼]

The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry properties arise for the age field. In particular, for a point release, the age field is isotropic, regardless of the direction of the ow and the value of the diffusion coefficient. The analysis is then extended to situations with time-varying currents, where the symmetry can be broken under some circumstances. Finally, we show a method by which a time-dependent problem can be used to assess a stationary concentration distribution function, providing details about the propagation of younger and older material at a given location. [less ▲]

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See detailA finite element formulation for spectral problems in optical fibers
Guenneau, S.; Nicolet, A.; Zolla, F. et al

in COMPEL (2001), 20(1), 120--131

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See detailValidation d'un test d'évaluation du comportement gestuel du patient lombalgique chronique
Vanderthommen, Marc ULg; Boulanger, A.S.; DEFAWEUX, Michel ULg et al

in Annales de Réadaptation et de Médecine Physique (2001), 44

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See detailVers un système d'information régional à caractère territorial
Rondeux, Jacques ULg

in Cahiers de l'Urbanisme (Les) (2001), (34), 73-79

Il n'est pas imaginable de penser, d'agir et de décider en matière de développement du territoire wallon, sans disposer d'informations de qualité sur les différentes facettes de l'occupation de l'espace ... [more ▼]

Il n'est pas imaginable de penser, d'agir et de décider en matière de développement du territoire wallon, sans disposer d'informations de qualité sur les différentes facettes de l'occupation de l'espace et nombre d'activités très diversifiées qui en découlent ou l'influencent. Créer une structure fonctionnelle interactive organisant la cohérence des données pertinentes, disponibles ou à récolter, évaluer leur validité, assurer et contrôler leur diffusion, en un mot gérer celles-ci pour mieux les valoriser justifie la création d'un outil mobilisateur d'aide à la décision dont les principaux objectifs, les concepts, l'organisation et les perspectives sont décrits dans les lignes qui suivent. [less ▲]

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See detailLes flux d'azote mobilisés par les agricultures belges
Debouche, Charles ULg

in Bulletin d'Information (Association Royale des Ingénieurs Issus de la Fusagx - Aigx) (2001), 4

Les flux de matières azotées mobilisés par les exploitations agricoles sont identifiés et quantifiés par divers modèles mathématiques. Ceux-ci sont conçus de manière à pouvoir être appliqués tant au ... [more ▼]

Les flux de matières azotées mobilisés par les exploitations agricoles sont identifiés et quantifiés par divers modèles mathématiques. Ceux-ci sont conçus de manière à pouvoir être appliqués tant au niveau d'une exploitation agricole qu'au niveau d'un territoire déterminé. Après avoir décrit succinctement ces modèles, leurs caractéristiques et leurs limites, le résultat de leur application aux agricultures flamande et wallonne est présenté. Il met en évidence une différence importante entre ces deux agricultures, notamment quant à leurs responsabilités environnementales. Les flux d'azote mobilisés par des exploitations agricoles existantes sont également estimés. Ils illustrent la grande diversité de comportement d'exploitations agricoles apparemment semblables. [less ▲]

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See detailA STUDY OF VACUUM FREEZE-DRYING OF FROZEN WET PAPERS
Carapelle, Alain ULg; Henrist, Marc; Rabecki, Frédéric ULg

in Drying Technology (2001), 19(6), 1113-1124

Vacuum freeze-drying of frozen wet papers was investigated experimentally. A freeze-drying facility was built to study the process by monitoring the various physical parameters (pressure, sample ... [more ▼]

Vacuum freeze-drying of frozen wet papers was investigated experimentally. A freeze-drying facility was built to study the process by monitoring the various physical parameters (pressure, sample temperature, heater temperature, water content of the sample and cold panel temperature). A simple phenomenological model was developed to explain experimental results. The values of the physical parameters were optimized to make the process cost effective. [less ▲]

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See detailDégradation de dalles de tablier de ponts en Belgique. Etude d'une pathologie complexe
Demars, Philippe; Gilles, Pierre; Darimont, Anne ULg

in Bulletin des Laboratoires des Ponts et Chaussées (2001), 232

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See detailProcollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis.
Fernandes, R. J.; Hirohata, S.; Engle, J. M. et al

in Journal of Biological Chemistry (2001), 276(34), 31502-9

The amino and carboxyl propeptides of procollagens I and II are removed by specific enzymes as a prerequisite for fibril assembly. Null mutations in procollagen I N-propeptidase (ADAMTS-2) cause ... [more ▼]

The amino and carboxyl propeptides of procollagens I and II are removed by specific enzymes as a prerequisite for fibril assembly. Null mutations in procollagen I N-propeptidase (ADAMTS-2) cause dermatosparaxis in cattle and the Ehlers-Danlos syndrome (dermatosparactic type) in humans by preventing proteolytic excision of the N-propeptide of procollagen I. We have found that procollagen II is processed normally in dermatosparactic nasal cartilage, suggesting the existence of another N-propeptidase(s). We investigated such a role for ADAMTS-3 in Swarm rat chondrosarcoma RCS-LTC cells, which fail to process the procollagen II N-propeptide. Stable transfection of RCS-LTC cells with bovine ADAMTS-2 or human ADAMTS-3 partially rescued the processing defect, suggesting that ADAMTS-3 has procollagen II N-propeptidase activity. Human skin and skin fibroblasts showed 30-fold higher mRNA levels of ADAMTS-2 than ADAMTS-3, whereas ADAMTS-3 mRNA was 5-fold higher than ADAMTS-2 mRNA in human cartilage. We propose that both ADAMTS-2 and ADAMTS-3 process procollagen II, but ADAMTS-3 is physiologically more relevant, given its preferred expression in cartilage. The findings provide an explanation for the sparing of cartilage in dermatosparaxis and, perhaps, for the relative sparing of some procollagen I-containing tissues. [less ▲]

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See detailDistinct carbohydrate recognition domains of an invertebrate defense molecule recognize Gram-negative and Gram-positive bacteria.
Bilej, M.; De Baetselier, P.; Van Dijck, E. et al

in Journal of Biological Chemistry (2001), 276(49), 45840-7

Coelomic fluid of Eisenia foetida earthworms (Oligochaeta, Annelida) contains a 42-kDa defense molecule named CCF for coelomic cytolytic factor. By binding microbial antigens, namely the O-antigen of ... [more ▼]

Coelomic fluid of Eisenia foetida earthworms (Oligochaeta, Annelida) contains a 42-kDa defense molecule named CCF for coelomic cytolytic factor. By binding microbial antigens, namely the O-antigen of lipopolysaccharide (LPS), beta-1,3-glucans, or N,N'-diacetylchitobiose present, respectively, on Gram-negative bacteria or yeast cell walls, CCF triggers the prophenoloxidase activating pathway. We report that CCF recognizes lysozyme-predigested Gram-positive bacteria or the peptidoglycan constituent muramyl dipeptide as well as muramic acid. To identify the pattern recognition domains of CCF, deletion mutants were tested for their ability to reconstitute the prophenoloxidase cascade in E. foetida coelomic fluid depleted of endogenous CCF in the presence of LPS, beta-1,3-glucans, N,N'-diacetylchitobiose, and muramic acid. In addition, affinity chromatography of CCF peptides was performed on immobilized beta-1,3-glucans or N,N'-diacetylchitobiose. We found that the broad specificity of CCF for pathogen-associated molecular patterns results from the presence of two distinct pattern recognition domains. One domain, which shows homology with the polysaccharide and glucanase motifs of beta-1,3-glucanases and invertebrate defense molecules located in the central part of the CCF polypeptide chain, interacts with LPS and beta-1,3-glucans. The C-terminal tryptophan-rich domain mediates interactions of CCF with N,N'-diacetylchitobiose and muramic acid. These data provide evidence for the presence of spatially distinct carbohydrate recognition domains within this invertebrate defense molecule. [less ▲]

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See detailHeterogeneity of (co)variance components for Jersey type traits
Gengler, Nicolas ULg; Dusseldorf, T.; Wiggans, G. R. et al

in Journal of Dairy Science (2001), 84

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See detailMerisier : les variétés multiclonales ont-elles un avenir ?
Curnel, Yanick; van de waele, Isabelle; Jacques, Dominique et al

in Silva Belgica (2001), 108(2), 32-37

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See detailWILSON "BOOZOO" CHAVIS - nécrologie
Sacré, Robert ULg

in Soul Bag (2001), (163), 42-43

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See detailEthnobotanical And Chemical Surveys Of An Edible Wild Legume: Uraria Picta (Jacq.) Dc.
Ambe, Guy-Alain; Lognay, Georges ULg; Wathelet, Bernard ULg et al

in Ecology of Food and Nutrition (2001), 40(5),

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See detailApplication of the accelerated shelf life testing method (ASLT) to study the survival rates of freeze-dried Lactococcus starter cultures
Achour, M.; Mtimet, N.; Cornelius, C. et al

in Journal of Chemical Technology & Biotechnology (2001), 74

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See detailGeometrical considerations for evaluation of reserve design.
Bogaert, Jan ULg; Salvador-Van Eysenrode, D; Van Hecke, P et al

in Web Ecology (2001), (2), 65-70

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See detailIntroduction à la programmation avec Matlab sous windows
Akossou, A. Y. J.; Fonton, N. H.; Claustriaux, Jean-Jacques ULg

in Notes de Biométrie et d'Informatique (2001), 2

This note aims to introduce Matlab software. Through this presentation we show a few advantages of the software. This presentation is then illustrated by a few examples of program with the software.

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See detailAll detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis.
Amoroso, Ana Maria ULg; Demares, D.; Mollerach, M. et al

in Antimicrobial agents and chemotherapy (2001), 45(7), 2075-81

All detectable high-molecular-mass penicillin-binding proteins (HMM PBPs) are altered in a clinical isolate of Streptococcus mitis for which the beta-lactam MICs are increased from those previously ... [more ▼]

All detectable high-molecular-mass penicillin-binding proteins (HMM PBPs) are altered in a clinical isolate of Streptococcus mitis for which the beta-lactam MICs are increased from those previously reported in our region (cefotaxime MIC, 64 microg/ml). These proteins were hardly detected at concentrations that saturate all PBPs in clinical isolates and showed, after densitometric analysis, 50-fold-lower radiotracer binding. Resistance was related to mosaic structure in all HMM PBP-coding genes, where critical region replacement was complemented not only by substitutions already reported for the closely related Streptococcus pneumoniae but also by other specific replacements that are presumably close to the active-site serine. Mosaic structure was also presumed in a pbp1a-sensitive strain used for comparison, confirming that these structures do not unambiguously imply, by themselves, detectable critical changes in the kinetic properties of these proteins. [less ▲]

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See detailMechanisms of unconsciousness during general anaesthesia
BONHOMME, Vincent ULg; Hans, Pol

in Current Anaesthesia and Critical Care (2001), (12), 109-113

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See detailA note on the use of fluorescently labelled algae for the determination of gut passage time in Bosmina and Daphnia
Cauchie, Henry-Michel ULg; Deguée, N.; Joaquim-Justo, Célia ULg et al

in Verhandlungen der Internationalen Vereinigung für Theoretische und Angewandte Limnologie = Proceedings of the International Association of Theoretical and Applied Limnology (2001), 27

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See detailAnalysis Of The Chromosome Sequence Of The Legume Symbiont Sinorhizobium Meliloti Strain 1021
Capela, Delphine; Barloy-Hubler, Frédérique; Gouzy, Jérôme et al

in Proceedings of the National Academy of Sciences of the United States of America (2001), 98(17),

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