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See detailUna Cabeza Bien Hecha O Una Cabeza Repleta ?
Crahay, Marcel ULg

in Perspectivas (1996), XXVI(1),

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See detailCrystallization and preliminary X-ray diffraction studies of a-amylase from the antarctic psychrophile Alteromonas haloplanctis A23
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (1996), 5(10), 2128-2129

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the ... [more ▼]

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the molecular basis of cold adaptations, crystallographic studies of this cold-adapted enzyme have been initiated because a three-dimensional structure of a mesophilic counterpart, pig pancreatic alpha-amylase, already exists. alpha-Amylase from A. haloplanctis, which shares 53% sequence identity with pig pancreatic alpha-amylase, has been crystallized and data to 1.85 A have been collected. The space group is found to be C222(1) with a = 71.40 A, b = 138.88 A, and c = 115.66 A. Until now, a three-dimensional structure of a psychrophilic enzyme is lacking. [less ▲]

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See detailPseudoaneurisma gigante del ventriculo izquierdo
Olivieri, E.; Guessaghi, R.; Chavin, A. et al

in Prensa Medica Argentina (1996), 83(10), 919-924

A 85 years old patient was hospitalized because of thoracic pain, lasting since three months. He suffered of Parkinson's disease and he was a smoker. The pain increased with cough and Vansalva's test. His ... [more ▼]

A 85 years old patient was hospitalized because of thoracic pain, lasting since three months. He suffered of Parkinson's disease and he was a smoker. The pain increased with cough and Vansalva's test. His left arm was cianotic. An arterial obstruction was suspected. Dopler ultrasound of the left arm confirmed a partial obstruction of the left axillar artery. Surprisingly, thoracic scan and MRI found an important cardiomegaly. The heart was in contact with the diaphragmatic and gastric region. Ecocardiography confirmed a 7 cm pseudo aneurysm of the left ventricle. Coronarography showed extreme hypokinesia of the left ventricle. There was also an obstruction of the right coronary and 50 % stenosis of the left coronary. Pseudo aneurysm was a complication of myocardial infarction of the left ventricle. Surgery was offered to the patient, but he declined the intervention. He was dismissed with medical treatment and anticoagulation. The patient deceased three months later. [less ▲]

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See detailThe development of a European questionnaire for quality of life in patients with vertebral osteoporosis
Lips, P; Agnusdei, D; Caulin, F et al

in Scandinavian Journal of Rheumatology (1996), 25(103), 84-85

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See detailOpportunities for using two low-cost methods for treatment of metal bearing aqueous streams
Gaydardzhiev, Stoyan ULg; Hadjihristova, M.; Tichy, R.

in Minerals Engineering (1996), 9

The feasibility of two non-traditional approaches - reedbeds as a natural wetland and adsorption on lignite and its maceral fractions - for their application in metal bearing effluent treatment is ... [more ▼]

The feasibility of two non-traditional approaches - reedbeds as a natural wetland and adsorption on lignite and its maceral fractions - for their application in metal bearing effluent treatment is discussed. The main mechanisms of metals uptake are otulined. The preliminary results from a pilot scale wetland operation for metallurgical effluents purification are analysed. For the second approach - the different maceral fractions derived from coal refining have shown different metal uptake apptitude. Zeta potential studies and adsorption isotherms have explained these findings. [less ▲]

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See detailPremière approche de la flore macrolichénique corticole de la Région de Bruxelles-Capitale en situation de dépollution au SO2
Tanghe, Martin; Richel, Thierry; Crisan, Florin et al

in Belgian Journal of Botany (1996), 129

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See detailMolecular Evidence That The Whitefly-Transmitted Sweetpotato Mild Mottle Virus Belongs To A Distinct Genus Of The Potyviridae
Colinet, Dominique; Kummert, Jean; Lepoivre, Philippe ULg

in Archives of Virology (1996), 141(1), 125-135

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See detailCalcium et squelette, base physiologique d’une prévention
Reginster, Jean-Yves ULg

in Les Nouvelles de Rhumatologie (1996), 1

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See detailFreud, l'individu et le groupe : Hier et aujourd'hui
Carels, N.; Gauthier, Jean-Marie ULg

in Revue Belge de Psychanalyse (1996), 29

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See detailA comprehensive pollen- and tephra- based chronostratigraphic model for the Late Glacial and Holocene Period in the French Massif Central.
Juvigné, Etienne ULg; Bastin, B; Delibrias, G et al

in Quaternary International (1996), 34-36

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See detailA systematic view on medical informatics.
Hasman, A; Haux, R; Albert, Adelin ULg

in Computer Methods & Programs in Biomedicine (1996), 51(3), 131-9

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics ... [more ▼]

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics (including health informatics), its aim, methods and tools, and its relevance to other disciplines in medicine and health sciences are outlined. It is recognized that one of the major tasks of medical informatics is modelling processes. In this context, biological, communication, decision, engineering, educational, organizational and computational processes are distinguished and described. [less ▲]

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See detailSexual differentiation of odor and partner preference in the rat.
Bakker, Julie ULg; Van Ophemert, J.; Slob, A. K.

in Physiology & Behavior (1996), 60(2), 489-94

Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an ... [more ▼]

Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an altered sexual partner preference. When tested in a three-compartment box, such gonadally intact ATD males approach and mate both with the estrous female and the sexually active male, whereas normal males prefer to approach and mate with the estrous female, avoiding the stimulus male. After castration in adulthood and estradiol treatment, ATD males prefer sexually active males. Similarly treated normal males prefer estrous females, and estrous females prefer to mate with males. In the present study, we asked what stimulus characteristics of active males vs. estrous females determined the different sexual preferences of males, ATD males, and of females. Were they chemosensory cues or more distal cues such as actually seeing and hearing the stimulus animals or the reward of sexual activity with the stimulus animals? Sex differences in preference were evident when animals were given a choice between soiled bedding from estrous females and from sexually active males. ATD and control males spent significantly more time on soiled bedding from estrous females than on soiled bedding from sexually active males. Control females spent significantly more time on soiled bedding from sexually active males than on soiled bedding from estrous females. More distal cues, such as seeing and hearing the stimulus animals, revealed differences in preference between control males and females, but not between ATD and control males. Physical interaction with the stimulus animals was a prerequisite for revealing differences in preference between ATD and control males. Then, the behavior of ATD males was clearly intermediate between that of normal male and female rats. In conclusion, neonatal estradiol is important for the psychosexual development of the male rat. However, the present data suggest that the psychosexual development of the male rat also requires either prenatal estradiol or perinatal testosterone. [less ▲]

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See detailOscillator strengths for Ca-like iron, cobalt and nickel (Fe VII, Co VIII, Ni IX)
Quinet, Pascal ULg; Hansen, J E

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailFinite element modelling of the competition between shear bands in the early stage of thrusting : Strain localisation and constitutive law influence
Barnichon, Jean-Dominique; Charlier, Robert ULg

in Special Publication - Geological Society of London (1996), 99

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See detailEnergy levels and oscillator strengths for transitions in Pd II
Quinet, Pascal ULg

in Physica Scripta (1996), 54

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See detailAcute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine.
Louis, Renaud ULg; Radermecker, Maurice ULg

in European Respiratory Journal (1996), 9(7), 1414-20

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in ... [more ▼]

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in the specific conductance (sGaw) and forced expiratory volume in one second (FEV1) in 12 asthmatics and 12 normal subjects after inhalation of doubling doses of PAF (15-120 micrograms) and methacholine (18 to at least 144 micrograms). In order to take into account a possible tachyphylaxis, we compared PAF dose-response curves performed on one day with the curves obtained by giving the same doses separately on different days. Repeated inhalations of doubling doses of PAF caused sGaw and FEV1 to plateau after the second dose in each group, whereas methacholine provoked a dose-related decrease in sGaw and FEV1. A dose-dependent decrease in the functional indices was restored when the different doses of PAF were administered on separate days. In both groups, the fall in sGaw after inhalation of 60 micrograms as a single dose was higher than that achieved when this dose was given during a full bronchial challenge. The falls in sGaw and FEV1 after PAF inhalation were significantly higher in the asthmatics than in the normal subjects. The provocative dose of PAF causing a 35% fall in sGaw (PD35,sGaw) PAF was only twofold lower in the asthmatics than in the normal subjects (p < 0.05), while it was 11 fold lower for methacholine (p < 0.001). When the PD35,sGaw values were compared, PAF was found on a molar basis to be 33 fold more potent than methacholine in the normal subjects, but only fivefold more potent in the asthmatics (p < 0.05). The percentage falls in FEV1 (calculated by interpolation) for a 35% fall in sGaw, were greater in asthmatics than in normals both for methacholine (p < 0.05) and PAF (p = 0.09). Our results demonstrate a tachyphylaxis after inhalation of platelet-activating factor in normal subjects and asthmatics, and show that asthmatics develop a greater bronchial obstruction than normal subjects even if methacholine is more sensitive than platelet-activating factor at discriminating between the two groups. [less ▲]

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See detailProduction of anti-PMSG antibodies and its relation to the productivity of rabbit does
Lebas, F.; Theau-Clement, M.; Remy, Benoît ULg et al

in World Rabbit Science (1996), 4(2), 57-62

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See detailDe wildste bloei van overgave en genade. Over Gezelle en Van Ostaijen
Spinoy, Erik ULg

in Gezelliana (1996), 8(1), 1-42

This article reflects on the importance of the 19th century romantic poet Guido Gezelle for the expressionist Paul van Ostaijen, who repeatedly stressed the pioneering character of this poetic oeuvre and ... [more ▼]

This article reflects on the importance of the 19th century romantic poet Guido Gezelle for the expressionist Paul van Ostaijen, who repeatedly stressed the pioneering character of this poetic oeuvre and the influence it had on his own work. [less ▲]

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See detailOrdovician and Silurian cryptospores and miospores from southeastern Turkey
Steemans, Philippe ULg; Le Hérissé, A; Bozdogan, N

in Review of Palaeobotany and Palynology (1996), 93(1-4), 35-76

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See detailLocalization of nucleic acids in hepatocyte nucleoli of rats upon D-galactosamine-induced block of transcription.
Mikhaylova, V. T.; Thiry, Marc ULg; Stephanova, E. et al

in Experimental Cell Research (1996), 225(2), 389-98

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection ... [more ▼]

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection: osmium-ammine staining and terminal deoxynucleotidyl transferase reaction for DNA, and immunoelectron microscopy with anti-RNA antibodies, RNase-gold, and autoradiography with tritiated orotic acid for RNA. The blocking of transcription was followed by the disappearance of intranucleolar condensed chromatin. Agglomerates of thin extended DNA filaments were found to change their location to the nucleolar periphery and to coalesce with each other. At the last stage of nucleolar segregation they were concentrated at the pole of the nucleolar fibrillar remnant while the rest of the nucleolus did not contain any DNA. No DNA was found in the dense fibrillar component of both intact and treated hepatocyte nucleoli. During the process of nucleolar segregation the bulk of the nucleolar RNA was found within the so-called spherical bodies. This RNA appeared to be synthesized shortly before or even after drug administration. The results obtained are in agreement with the hypothesis that the fibrillar centers are the site of nucleolar transcription. They also show that uncompleted molecules of pre-rRNA whose synthesis has been blocked are segregated from the rest of nucleolar RNA species into the spherical bodies. [less ▲]

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See detailDe modernist en de massacultuur: Van Ostaijens ‘Huldegedicht aan Singer’
Spinoy, Erik ULg

in Filosofie Magazine (1996), 5(3), 29

This article re-reads the famous poem 'Huldegedicht aan Singer' in view of Van Ostaijen's increasingly critical attitude towards the emerging consumer society of the 1920s.

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See detailCaractéristiques des lésions résultant d'une pathologie périnatale
Dubru, Jean-Marie ULg; Leroy, Patricia; Misson, Jean-Paul ULg

in Acta Paediatrica Belgica (1996), 28(3), 203-204

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See detailA simple technique to relieve Tribolium castaneum (Coleoptera: Tenebrionidae) of Acarophenax tribolii (Acarina: Pyemotidae).
Arnaud, Ludovic; Mignon, Jacques ULg; Gilson, Jean-Claude et al

in Tribolium Information Bulletin (1996), 36

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See detailLe cas clinique du mois : syndrome de Moskowitz chez un patient traité par ticlopidine
FRANCHIMONT, D; Freres, Pierre ULg; LEBRUN, F et al

in Revue Médicale de Liège (1996), 51(3), 214-216

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See detailRNA editing of larch mitochondrial tRNA(His) precursors is a prerequisite for processing
MarechalDrouard, L.; Kumar, R.; Remacle, Claire ULg et al

in Nucleic Acids Research (1996), 24(16), 3229-3234

Larch mitochondria contain a 'native' tRNA(His) which is absent from angiosperms, Sequence comparisons of genomic DNA and cDNA obtained from unprocessed primary transcripts of the larch mitochondrial gene ... [more ▼]

Larch mitochondria contain a 'native' tRNA(His) which is absent from angiosperms, Sequence comparisons of genomic DNA and cDNA obtained from unprocessed primary transcripts of the larch mitochondrial gene trnH encoding this tRNA revealed three nucleotide discrepancies. These three nucleotide alterations, in the acceptor stem, D stem and anticodon stem respectively, are conversions of genomic cytidines to thymidines in the cDNA (uridines in the tRNA) and thus resemble the RNA editing events observed in nearly all plant mitochondrial mRNAs. Two cases of editing affecting mitochondrial tRNAs from angiosperms have already been described, but we present here the first example of such events in a gymnosperm mitochondrial tRNA. All three editing events correct mismatched C . A base pairs which appear when folding the gene sequence into the standard cloverleaf structure, thereby improving the secondary structure of the tRNA. When incubated with a heterologous potato mitochondrial processing extract, only the edited form of the larch mitochondrial tRNA(His) precursor was efficiently processed in vitro. These data strongly suggest that editing of larch mitochondrial tRNA(His) is a prerequisite for its processing. [less ▲]

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See detailThe Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment: Deployment on the ATLAS Space Shuttle missions
Gunson, Michael R.; Abbas, M. M.; Abrams, M. C. et al

in Geophysical Research Letters (1996), 23(17), 2333-2336

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events ... [more ▼]

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events provided measurements of more than 30 atmospheric trace gases at latitudes 3-49 degrees N and 65-72 degrees S, including observations both inside and outside the Antarctic polar vortex. The instrument configuration, data retrieval methodology, and mission background are described to place in context analyses of ATMOS data presented in this issue. [less ▲]

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See detailLa pratique de la mise en observation psychiatrique
Boxho, Philippe ULg

in Revue Médicale de Liège (1996), 52

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See detailQuestions de regards
Havelange, Carl ULg

in Le Carnet et les Instants (1996), septembre-novembre 1996(n° 94), 57

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See detailTussen moderniteit en reactionair katholicisme. Joris van Severen en het eerste nummer van Ter Waarheid
Spinoy, Erik ULg

in Dietsche Warande en Belfort (1996), 140(6), 700-714

This article takes a closer look at the literary, artistic and ideological programme of the first issue of Ther Waarheid, the journal published by Joris van Severen, who would go on to become one of the ... [more ▼]

This article takes a closer look at the literary, artistic and ideological programme of the first issue of Ther Waarheid, the journal published by Joris van Severen, who would go on to become one of the leaders of Flemish fascism in the 1930s. [less ▲]

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See detailImproved RAPD amplification of recalcitrant plant DNA by the use of activated charcoal during DNA extraction.
Vroh Bi, I.; Harvengt, L.; Chandelier, A. et al

in Plant Breeding (1996), 115(3),

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See detailPratiques d'auto-formation : une enquête en communauté française de Belgique
Denis, Brigitte ULg

in Cahiers d'Etudes du C U E E P (1996), 32-33

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See detailRené Zazzo, poète et psychologue
Richelle, Marc ULg

in Enfance (1996), (2), 233-237

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See detailBequest motives and the level and composition of wealth in Belgium. A survey based analysis
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Cahiers Economiques de Bruxelles (1996), (149), 31-53

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See detailPrognostic indices for mortality of hospitalized children in central Africa.
Dramaix, M.; Brasseur, D.; Donnen, P. et al

in American journal of epidemiology (1996), 143(12), 1235-43

A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This ... [more ▼]

A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This study analyzes the mortality in hospital; its objectives are to evaluate the prognostic power of edema and anthropometric and biologic indicators and to seek indices that perform better. Receiver operating characteristic curves were established for each parameter under study and for each index constructed. Areas under receiver operating characteristic curves were highest for biologic indicators, and simple indices, obtained by counting the number of risk factors present, performed best. In the absence of biologic parameters, the authors suggest classifying children as at risk of dying when they present with edema and/or with arm circumference of less than 115 mm. When biologic measurements are possible, in addition to edema and arm circumference, the authors suggest taking serum albumin and transthyretin into account. For serum albumin and transthyretin, mortality risk is defined in terms of values of less than 16 g/liter and 6.5 mg/dl, respectively. Children will be classified as at risk of dying when they present with at least two of the four risk factors. The resulting diagnostic test has a high sensitivity (91.2%) and positive and negative predictive values of 40.8% and 97.9%, respectively. [less ▲]

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See detailGuide bibliographique pour l'histoire de la principauté de Liège au 18e siècle : La vie intellectuelle
Droixhe, Daniel ULg; Vanwelkenhuyzen, Nadine ULg

in Annuaire d'Histoire Liégeoise (1996), Numéro spécial

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See detailAge and correlation of the Barreinrinha Formation (Curua Group, Amazon Basin) : new evidence from the Miospore biostratigraphy
Loboziak, S.; Melo, J.H.G.; Rodriguez, R. et al

in Anais da Academia Brasileira de Ciencias (1996), 68(2), 207-212

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See detailThe relation of ventilatory failure to pulmonary, respiratory muscle and central nervous system disturbances in calves with an experimentally produced pneumonia
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Journal of Comparative Pathology (1996), 115(3), 203-219

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a ... [more ▼]

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a period of 10 h. Measurements were made of inspired minute ventilation VE), ventilatory pattern [inspiratory time (TI), expiratory time (TE), respiratory rate (RR) and tidal volume (VT)], transdiaphragmatic pressure (Pdi), occlusion pressure at the airway opening 100 milliseconds after onset of inspiration (Pawo100ms), arterial blood gas tensions and pH and recorded diaphragmatic electromyogram (EMGdi) and rectal temperature (Tr). On and after the third hour after inoculation, the animals varied in respect of clinical signs, Tr, RR, VE, Pawo100ms/EMGdi, and arterial gases and pH. In benign cases, diminished alertness, laboured respiration and fall of arterial oxygen pressure (PaO2) worsened up to 7 h after inoculation, but then progressively improved, VE being maintained at approximately 150% baseline throughout the study (10 h). Neither arterial carbon dioxide pressure (PaCO2) nor pH was altered. Moderate cases resembled benign cases in respect of laboured respiration, VE, PaO2 and PaCO2; however, pH was at first maintained at preinoculation levels, but declined thereafter. In severe cases, the animals were drowsy between hours 3 and 7, and became comatose between hours 8 and 10; in contrast to both benign and moderate cases: (1) RR was reduced by hour 5, (2) there was no trend towards recovery of PaO2 and pH, (3) VE, Pdi, Pawo100ms and Pawo100ms/EMGdi were severely decreased, and (4) PaCO2 increased. These results suggest that pneumonia does not alter ventilatory neuromuscular pump function in calves, unless concomitant cardiovascular collapse occurs. It is not clear whether fatal ventilatory failure is caused mainly by deterioration in ventilatory muscle fibre processes or structures, altered central nervous system adjustment of ventilatory timing, or cardiovascular dysfunction. However, inspiratory pressures fall when excitation to the diaphragm is still growing, which suggests peripheral respiratory muscle fatigue. [less ▲]

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See detailPeritoneal endometriosis and "endometriotic" nodules of the rectovaginal septum are two different entities.
Donnez, Jacques; NISOLLE, Michelle ULg; Smoes, Pierre et al

in Fertility and Sterility (1996), 66(3), 362-8

OBJECTIVES: To compare histologically and stereologically the endometriotic nodule of the rectovaginal septum to peritoneal endometriosis. DESIGN: Morphometric investigation, cytokeratin and vimentin ... [more ▼]

OBJECTIVES: To compare histologically and stereologically the endometriotic nodule of the rectovaginal septum to peritoneal endometriosis. DESIGN: Morphometric investigation, cytokeratin and vimentin content, and steroid receptor evaluation were performed on endometriotic tissue from the peritoneum (n = 52) and rectovaginal nodules (n = 68). SETTING: An academic teaching hospital. PATIENTS: Biopsies were taken from 120 patients undergoing a laparoscopy for infertility and/ or pelvic pain (52 from typical black peritoneal endometriotic implants and 68 from endometriotic nodule of the rectovaginal septum). None of the patients were treated. RESULTS: Mitotic activity was found to be significantly different in peritoneal and rectovaginal endometriosis. The evaluation suggested that the stroma is not mandatory for the invasion of glandular epithelium in the rectovaginal nodule, which is, like a adenomyoma, a circumscribed nodular aggregate of smooth muscle and glandular elements. Cytokeratin and vimentin content as well as the estrogen receptor (ER) and P receptor (PR) content were significantly lower in both types of lesion when compared with eutopic endometrium. But vimentin immunoreactivity in epithelium, as well as the ER and PR content, were significantly lower in nodules when compared with black peritoneal lesions. CONCLUSION: It is suggested that the rectovaginal endometriotic nodule is a different disease from peritoneal endometriosis and must be called rectovaginal adenomyosis or rectovaginal adenomyoma. Its histopathogenesis probably is not related to the implantation of regurgitated endometrial cells but to the metaplasia of Müllerian rests. [less ▲]

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See detailThe Ahrensburgian site at Zonhoven-Molenheide
Vermeersch, Pierre M.; Peleman, Chris; Rots, Veerle ULg et al

in Notae Praehistoricae (1996), 16

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See detailCurrent therapies for shingles
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Expert Opinion on Investigational Drugs (1996), 5

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but ... [more ▼]

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but its moderate bioavailability renders five oral daily doses mandatory. Recent anti-VZV drug research has been oriented towards agents with increased oral bioavailability. Famciclovir and valaciclovir were originally developed as oral prodrugs for^penciclovir and acyclovir, respectively, but, together with the new antivirals, sorivudine and brovavir, they appear to be effective as oral therapy for shingles. Ongoing clinical trials will determine their relative merits in the management of shingles. The experimental agents H2G, HPMPC, mappicine ketone and A-73209 have potential in the treatment of VZV and are undergoing further investigation and development. [less ▲]

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See detailPreliminary study of the Black Sea's plankton bloom
Grégoire, Marilaure ULg; Beckers, Jean-Marie ULg; Nihoul, Jacques ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1996), 65(1), 91-94

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See detailHacia una cartografía del boom. Una polémica en Zona Franca (ag.-dic.1972).
Vanden Berghe, Kristine ULg

in América. Cahiers du CRICCAL (1996), 15/16

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See detailDifférenciation génétique et morphologique du mulot, Apodemus sylvaticus, dans le bassin Méditerranéen occidental
Michaux, Johan ULg; Libois, Roland ULg; Fons, Roger

in Vie et Milieu (1996), 46(3-4), 193-203

Many questions are still unanswered about the biogeography and the origin of the wood mouse in the Mediterranean area, namely on the islands where some giant forms are described. In order to characterize ... [more ▼]

Many questions are still unanswered about the biogeography and the origin of the wood mouse in the Mediterranean area, namely on the islands where some giant forms are described. In order to characterize the genetic structure of these insular populations and their level of morphological differentiation, 232 animals originating from 30 localities situated on several western Mediterranean islands and on the continent, either along the sea coast or more inland, were trapped. Their skulls were measured and their mtDNA purified and analysed by RFLP techniques. The wood mice living on small islands are generally bigger than their relatives living on the continent whereas the size of those living on larger islands is quite the same. This kind of insular gigantism ought to be more an adaptive response to peculiar insular environmental conditions (particularly a lower predation pressure) than a consequence of a founder effect. The mtDNA of the wood mice from north-eastern Spain belongs to the previously identified northwestern group (Michaux et al., 1996). Consequently, the Pyrenees are not a biogeographic barrier to the wood mouse. The Sicilian mice, which are genetically different from all the other west European or north-African animals, are morphologically similar to the Sardinian and Italian ones. [less ▲]

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See detailComparative evaluation of impulse oscillometry and a monofrequency forced oscillation technique in clinically healthy calves undergoing bronchochallenges
Reinhold, Petra; MacLeod, D.; Lekeux, Pierre ULg

in Research in Veterinary Science (1996), 61

Multifrequency impulse oscillometry (IOS) was compared with a monofrequency forced oscillation technique (MFO) in calves undergoing experimentally induced bronchoconstriction and subsequent ... [more ▼]

Multifrequency impulse oscillometry (IOS) was compared with a monofrequency forced oscillation technique (MFO) in calves undergoing experimentally induced bronchoconstriction and subsequent bronchodilatation. The dynamic lung compliance (Cdyn) was also measured by conventional methods. For each test, the baseline mean and the responses to saline, a bronchoconstrictive agent (carbachol) and a bronchodilator (fenoterolhydrobromide) were calculated. Using the IOS, the information was markedly frequency-dependent. The resistance (R) and the magnitude of respiratory impedance (Z) were only sensitive at 5 Hz, leading to negative frequency dependence of these parameters as an indicator of peripheral airway obstruction. A high sensitivity for reactance (X) and phase angle phi values was observed between 5 and 20 Hz. For MFO (10 Hz), the parameters Ros (which includes resistive and capacitive components of the respiratory system), phase shift (psi), and the oscillatory derived compliance of the respiratory system (Crs) were of the greatest clinical potential. Crs showed a significant coefficient of linear correlation (r = 0.88, P < 0.001) with Cdyn. At the 10 Hz test frequency similar results were observed with MFO and IOS, suggesting that for healthy calves the measurement effect of an impulse is not significant. With respect to peripheral airway calibre, a test frequency less than 10 Hz appeared to be most sensitive and least variable. [less ▲]

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See detail"Parce que je ne connais pas bien le grec..." (P. Col. Zen. II 66)
Rochette, Bruno ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1996), 71(142), 311-316

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See detailRecently advanced computerized technology was applied to the investigation of morphometric, immunohistological and three-dimensional changes of the endometrial mucosa in order to evaluate quantitatively the effects of three doses of a new slow-release vaginal progesterone on the endometrium in post-menopausal women. A total of 20 menopausal women, deprived of ovarian function, were given oestrogen for 12 days and a combined therapy of oestrogen (administered orally) and progesterone for another 12 day period. Progesterone was administered vaginally through a new gel (Crinone) utilizing a bioadhesive, biocompatible polymer as a base to achieve a sustained release effect. An endometrial biopsy was taken before treatment, after oestrogen-only treatment and after the oestro-progestogen therapy. Before treatment, all the patients exhibited an atrophic endometrium. After oestrogen-only treatment, typical proliferative changes occurred: an increase in the endometrium thickness, an increase in the mitotic index, numerous cylinder-like glands and no coiled glands, and high concentrations of oestrogen receptors (ER) and progesterone receptors (PR). After the oestro-progestogen therapy, whatever the dose of progesterone given, a secretory transformation of the endometrial mucosa occurred, mitotic activity decreased significantly, more ramified and coiled glands were observed, and a decrease in PR content was noted in epithelial and stromal nuclei, and a decrease in PR content was also observed in epithelial nuclei but not in stromal nuclei. Accurate new techniques of image analysis have shown that crinone therapy could eliminate the proliferative effects of oestrogen treatment in post-menopausal women, despite doses as low as 45 mg of progesterone administered vaginally every other day. The results suggest that the sustained release effects of Crinone are clinically relevant.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise et al

in Human Reproduction (1996), 11(1), 224-8

A computerized morphometrical investigation was performed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologically the ... [more ▼]

A computerized morphometrical investigation was performed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologically the rectovaginal septum endometriotic nodule to peritoneal endometriosis. Mitotic activity, stromal vascularization and the epithelium/stroma ratio were found to be significantly different in peritoneal and rectovaginal endometriosis. The evaluation revealed a major role of glandular epithelium in rectovaginal nodules where the stroma sometimes appeared absent around glandular epithelium. The study demonstrated opposite effects of gonadotrophin-releasing hormone agonists (GnRHa) and lynestrenol on the two lesions. Indeed, in peritoneal endometriosis, after GnRHa therapy, our study demonstrated a lower rate of mitosis and poor stromal vascularization. The same drug was unable to induce the same effects in the nodule although, in contrast, lynestrenol has a strong effect on nodule vascularization. In conclusion, it is suggested that the rectovaginal adenomyotic nodule is a specific disease, different from peritoneal endometriosis. It is not the consequence of 'deep infiltrating' endometriosis but can probably develop from Mullerian rests present in the rectovaginal septum. [less ▲]

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See detailThe catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.
Damblon, Christian ULg; Raquet, X.; Lian, L. Y. et al

in Proceedings of the National Academy of Sciences of the United States of America (1996), 93(5), 1747-52

Beta-Lactamases are widespread in the bacterial world, where they are responsible for resistance to penicillins, cephalosporins, and related compounds, currently the most widely used antibacterial agents ... [more ▼]

Beta-Lactamases are widespread in the bacterial world, where they are responsible for resistance to penicillins, cephalosporins, and related compounds, currently the most widely used antibacterial agents. Detailed structural and mechanistic understanding of these enzymes can be expected to guide the design of new antibacterial compounds resistant to their action. A number of high-resolution structures are available for class A beta-lactamases, whose catalytic mechanism involves the acylation of a serine residue at the active site. The identity of the general base which participates in the activation of this serine residue during catalysis has been the subject of controversy, both a lysine residue and a glutamic acid residue having been proposed as candidates for this role. We have used the pH dependence of chemical modification of epsilon-amino groups by 2,4,6,-trinitrobenzenesulfonate and the pH dependence of the epsilon-methylene 1H and 13C chemical shifts (in enzyme selectively labeled with [epsilon-13C]lysine) to estimate the pKa of the relevant lysine residue, lysine-73, of TEM-1 beta-lactamase. Both methods show that the pKa of this residue is > 10, making it very unlikely that this residue could act as a proton acceptor in catalysis. An alternative mechanism in which this role is performed by glutamate-166 through an intervening water molecule is described. [less ▲]

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See detailManger juste. Les droits de l'animal dans les encyclopédies de 1750 à 1800. De l'éthique au politique
Strivay, Lucienne ULg

in Colloques d'Histoire des Connaissances Zoologiques (1996), 7

Les encyclopédistes du 18° inclurent leurs définitions de la spécificité humaine par rapport à celle de l'animal dans leur nouvelle synthèse du savoir. A la même époque, resurgit le concept des "droits de ... [more ▼]

Les encyclopédistes du 18° inclurent leurs définitions de la spécificité humaine par rapport à celle de l'animal dans leur nouvelle synthèse du savoir. A la même époque, resurgit le concept des "droits de l'animal" (relayant les anciens procès intentés à des animaux). La communication examine comment Diderot et d'Alembert, Panckoucke, Robinet, De Lisle de Sales, Valmont de Bomare, etc., s'y prirent pour concilier les droits de l'homme et ceux de l'animal dans les articles de leurs encyclopédies. Si l'animal appartient à la catégorie de "l'autre", sa proximité avec l'homme, en raison du développement des premières intuitions transformistes et du sensualisme matérialiste, s'affirme de plus en plus, en opposition au cartésianisme qui considérait l'animal comme une machine et l'écartait, par essence, de l'homme et de Dieu. En conséquence, les points de vue qui s'expriment au siècle des Lumières au sujet des animaux ont suscité des idées dérangeantes sur le lien unissant tous les êtres vivants entre eux et, d'autre part, ils ont soulevé de nouvelles questions, les unes théoriques : au sujet de l'origine des espèces, les autres pratiques : sur le droit de l'homme à manger les animaux, le choix des viandes et ses conséquences morales, voire politiques. Car, fondé comme il l'est sur des formes de violence publique ou privée, l'abattage des animaux afin de produire de la viande a toujours eu de nombreuses implications, notamment sociales, propres à induire finalement des réformes ou des changements d'ensemble. [less ▲]

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See detailA promoter element active in run-off transcription controls the expression of two cistrons of nad and rps genes in Nicotiana sylvestris mitochondria
Lelandais, C.; Gutierres, S.; Mathieu, C. et al

in Nucleic Acids Research (1996), 24(23), 4798-4804

The expression of two mitochondrial gene clusters (orf87-nad3-nad1/A and orf87-nad3-rps 12) was studied in Nicotiana sylvestris. 5' and 3' termini of transcripts were mapped by primer extension and ... [more ▼]

The expression of two mitochondrial gene clusters (orf87-nad3-nad1/A and orf87-nad3-rps 12) was studied in Nicotiana sylvestris. 5' and 3' termini of transcripts were mapped by primer extension and nuclease S1 protection. Processing and transcription initiation sites were differentiated by in vitro phosphorylation and capping experiments. A transcription initiation site, present in both gene clusters, was found 213 nucleotides upstream of orf87. This promoter element matches the consensus motif for dicotyledonous mitochondrial promoters and initiates run-off transcription in a pea mitochondrial purified protein fraction, Processing sites were identified 5' of nad3, nad1/A and rps12 respectively. These results suggest that (i) the expression of the two cistrons is only controlled by one duplicated promoter element, and (ii) multiple processing events are required to produce monocistronic nad3, nad1/A and rps12 transcripts. [less ▲]

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See detailPaget’s disease of bone : diagnosis and management
Hosking, D; Meunier, PJ; Ringe, JD et al

in British Medical Journal (1996), 312

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See detailMagnetic alignment in 2212 Bi-based superconducting system .1. Magnetic orientation of Bi2Sr2Ca1-x(RE)(x)Cu2O8-y [(RE)=Gd, Dy, Ho, Er] powder dispersed in epoxy resin at room temperature
Stassen, S.; Cloots, Rudi ULg; Vanderbemden, Philippe ULg et al

in Journal of Materials Research (1996), 11(5), 1082-1085

The magnetic anisotropy of rare-earth substituted 2212 materials (Bi(2)Sr(2)Ca(0.8)RE(0.2)Cu(2)O(x) with RE = Gd, Dy, Ho, Er) is put into evidence. Superconducting powder dispersed in epoxy resin is ... [more ▼]

The magnetic anisotropy of rare-earth substituted 2212 materials (Bi(2)Sr(2)Ca(0.8)RE(0.2)Cu(2)O(x) with RE = Gd, Dy, Ho, Er) is put into evidence. Superconducting powder dispersed in epoxy resin is oriented under an external magnetic field (4 T) in a direction that depends on the nature of the rare-earth used in the substitution. Both directions of observation (parallel or perpendicular to the field) were investigated. Splitting of (00l) peaks is neatly observed and discussed. [less ▲]

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See detailEstimations du taux de la plus-value en Belgique (1948-1994): méthode et résultats
Geerkens Provin, Eric ULg

in Contradictions (1996), (78-79), 85-98

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See detailDeposition in the Distal Parts of the Bovine Respiratory Tract: Assessment of Equipment Suitable for Drug Inhalation
Genicot, Bruno; Votion, Dominique ULg; Munsters, K. et al

in Veterinary Record : Journal of the British Veterinary Association (1996), 138(13), 302-304

The efficiency of equipment suitable for the inhalation of drugs by calves was assessed in six animals which inhaled radioisotopically labelled particles while suffering from reversible diffuse ... [more ▼]

The efficiency of equipment suitable for the inhalation of drugs by calves was assessed in six animals which inhaled radioisotopically labelled particles while suffering from reversible diffuse bronchoconstriction induced experimentally with 5-hydroxytryptamine and while they were breathing normally. Respiratory rates and data from pulmonary function tests and scintiscans were recorded during both investigations. After the first investigation, a mean (se) wash-out period of 9.8 (3.2) days was allowed. Under diffuse bronchoconstriction, the respiratory rate, the oscillatory resistance and the compliance of the respiratory system reached 282.1 (22.0), 161.1 (10.8) and 68.8 (2.7) per cent of their respective baseline values. When the calves were breathing normally these parameters did not change over time. The ratios (Cp/Ct) of the counts of gamma-disintegrations in the peripheral part (Cp) of the lungs and in the total lung area (Ct) were not significantly different when comparing the results from the two investigations. The ratios of Cp/Ct in the left lungs did not differ significantly from those in the right lungs. [less ▲]

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See detailCalculation of inner shell transitions in Mn+
Quinet, Pascal ULg; Hibbert, A

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailStable isotope studies: a remarkable tool in delianating organic matter pathways between pelagic and benthic realms. In memoriam Fiorentina Mosora
Mosora, Fiorentina; Dauby, Patrick ULg

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailPhylogenetic Relationships of Nonaxenic Filamentous Cyanobacterial Strains Based on 16S rRNA Sequence Analysis
Nelissen, Bart; De Baere, Raymond; Wilmotte, Annick ULg et al

in Journal of Molecular Evolution (1996), 42

In order to determine the nearly complete 16S rRNA gene sequences of cyanobacteria originating from nonaxenic cultures, a cyanobacterium-specific oligonucleotide probe was developed to distinguish ... [more ▼]

In order to determine the nearly complete 16S rRNA gene sequences of cyanobacteria originating from nonaxenic cultures, a cyanobacterium-specific oligonucleotide probe was developed to distinguish polymerase chain reaction (PCR) products of the cyanobacterial rRNA operons from those resulting from amplification of contaminating bacteria. Using this screening method the 16S rRNA genes of four nonaxenic filamentous cyanobacterial strains belonging to the genera Leptolyngbya and OscitIatoria were cloned and sequenced. For the genus Leptolyngbya, the 16S rRNA sequence of the axenic strain PCC 73110 was also determined. Phylogenetic trees were constructed based on complete and partial sequences. The results show that the strains Leptolyngbya Jbveolarum Kom~rek 1964/112, Leptolyngbya sp. VRUC 135 Albertano t985/1, and LeptoIyngbya boryanum PCC 73110 belong to the same cluster. Strain Oscillatoria cf. corallinae SAG 8.92, which contains the rare photosynthetic pigment CUphycoerythrin, is not closely related to other CUphycoerythrin- containing cyanobacteria. Oscillatoria agardhii CYA 18, which is a representative of planktonic Oscillatoria species that form toxic blooms in Norwegian inland waters, has no close relatives in the tree. [less ▲]

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See detailRecommendations for registration of drugs used in the treatment of osteoarthritis
Dougados, M; Devogelaer, JP; Annefeldt, M et al

in Annals of the Rheumatic Diseases (1996), 55

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See detailLa genèse du héros médiocre. Simenon à l'époque Fayard
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (1996), (8), 27-42

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See detailLe Rohypnol, une drogue dure amnésiante : résultats d'une recherche en médecine de famille
Jamoulle, Marc ULg

in Psychotropes : Revue Internationale des Toxicomanies et des Addictions (1996), 2(2), 53-66

Objectifs : Etudier le profil de l'usage de médicaments chez les toxicomanes à l'héroïne Sujets et méthodes : 89 héroïnomanes, enrôlés dans un programme de maintenance par la méthadone en médecine de ... [more ▼]

Objectifs : Etudier le profil de l'usage de médicaments chez les toxicomanes à l'héroïne Sujets et méthodes : 89 héroïnomanes, enrôlés dans un programme de maintenance par la méthadone en médecine de famille, ont fait l'objet d'une enquête. Les patients pharmacophiles et leurs préférences ont été identifiés par questionnaire. L'enregistrement d'interviews face à face semistructurés a permis de mettre en évidence le profil de 56 patients ainsi que le tableau clinique résultant de l'abus de médicament. Une revue bibliographique et une investigations auprès de praticiens de différents pays renforcent l'étude. Résultats : 60%(53/89) des consultants ont abusé de médicaments au moins une fois. Le Rohypnol™ (Flunitrazépam), un hypnotique puissant, est placé en premier choix comme succédané de l'héroïne par 66% de ces utilisateurs abusifs. " Etre en Roche " est une expression utilisée par les toxicomanes euxmêmes pour désigner le tableau clinique consécutif à la prise diurne d'un ou plusieurs (jusqu'à 30 c à 2mg par jour) comprimés de Rohypnol™, associé ou non à l'alcool. Un comprimé de Rohypnol™est appelé un " Roche " et un utilisateur compulsif un " Rocheman ". Le tableau clinique est caractérisé par un état d'obnubilation ( « Etre ravagé, pété, mort »), une dysarthrie, une sensation d'invincibilité, une perte d'inhibition avec possible passage à l'acte et agression suivis d'endormissement et d'amnésie antérograde totale. L'information concernant la dangerosité de ce produit n'a pas été diffusée . Le Rohypnol™ est une drogue de rue dans tous les pays étudiés. Conclusions : Le Rohypnol™ est une drogue dure, succédané de l'héroïne et un amnésiant puissant. Ce produit est dangereux par son pouvoir amnésiant et désinhibant. Ce produit n'a plus de place en thérapeutique. [less ▲]

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See detailA study of general practitioners' prescribing behaviour to the elderly in Wallonia, Belgium
Taziaux, P.; Franck, J.; Ludovicy, R. et al

in European Journal of Public Health (1996), 6(1)

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See detailSeasonal and interannual influences of the terrestrial ecosystems on atmospheric CO2: a model study
François, Louis ULg; Nemry, Bernard; Warnant, Pierre ULg et al

in Physics & Chemistry of the Earth - Parts A/B/C (1996), 21

The prognostic CARAIB (Carbon Assimilation In the Biosphere) model has been used in conjunction with the Max-Planck Institut TM2 atmospheric transport model to calculate the atmospheric CO2 fluctuations ... [more ▼]

The prognostic CARAIB (Carbon Assimilation In the Biosphere) model has been used in conjunction with the Max-Planck Institut TM2 atmospheric transport model to calculate the atmospheric CO2 fluctuations at the global scale. Two applications are briefly described. In the first one, the seasonal CO2 variation is calculated and a Fourier analysis is performed to determine the relative contributions of the various vegetation types. It is found that the seasonal signal is dominated by the grasslands and needle leaf forests in the northern boreal and temperate zones. In the southern hemisphere, tropical deciduous forests and grasslands make the primary contribution. In the second application, the net primary productivity (NPP), soil heterotrophic respiration (SHR) and net ecosystem productivity (NEP) are calculated for years 1987 and 1988 with the model driven by observed climatic variables. Preliminary results indicate that the NEP variations between these two years are strongly dominated by tropical ecosystems. However, it is shown that the results are strongly dependent on the dataset used for the 1987-88 temperature record, raising the question of reliability of sudl modelling studies of the interannual variability of the biosphere. 01997 Elsevier Science Ltd [less ▲]

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See detailImplicit learning in amnesic subjects: A comparison with a large group of normal control subjects
Wilson, B. A.; Green, R.; Teasdale, T. et al

in Clinical Neuropsychologist (1996), 10

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See detailL'échec, un problème de culture pédagogique
Crahay, Marcel ULg

in Journal of Education (1996), Octobre

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See detailLaparoscopic myomectomy today. Fibroids: management and treatment: the state of the art.
Donnez, Jacques; Mathieu, Pierre Emmanuel; Bassil, Salim et al

in Human Reproduction (1996), 11(9), 1837-40

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See detailCO2 atmosphérique et simulation de ses variations d'origine naturelle et anthropique
Gérard, Jean-Claude ULg; François, Louis ULg

in Revue de la Science et des Techniques (1996), 14

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1996), 37

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See detailBibliographie de Jean Haust
Boutier, Marie-Guy ULg

in Dialectes de Wallonie (1996), 23-24

Bibliographie de Jean Haust et index raisonné de l'ensemble de l'oeuvre.

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See detailLe campus universitaire comme espace public : des représentations aux pratiques
Frankignoulle, Pierre ULg; Bodson, Edith

in Etudes de Communication (1996), 18

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See detailMise au point relative à l'utilisation de la gonadolibérine en reproduction bovine. 1. Justifications physiologiques de son application au traitement de l'infertilité
Hanzen, Christian ULg; Houtain, Jean Yves; Laurent, Yves

in Médecin Vétérinaire du Québec (1996), 26(1), 7-10

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See detailUtilisation des antibiotiques dans la maladie de Crohn : de la théorie à la pratique
Louis, Edouard ULg; Drion, V.; Belaiche, Jacques ULg

in Médecine et Hygiène (1996), 54

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See detailLa surveillance de l'environnement à la F.U.L.
Nicolas, Jacques ULg

in Environnement et Société (1996), (15/16), 17-30

L'article décrit les activités de recherche et d'enseignement en surveillance de l'environnement à la Fondation Universitaire Luxembourgeoise à Arlon. Il présente le contexte historique qui a initié ces ... [more ▼]

L'article décrit les activités de recherche et d'enseignement en surveillance de l'environnement à la Fondation Universitaire Luxembourgeoise à Arlon. Il présente le contexte historique qui a initié ces activités, intégrant plusieurs chercheurs de disciplines diverses. Travailler sur le milieu naturel impose des contraintes, mais celles-ci sont compensées par une exigence modérée en ce qui concerne la précision de certains résultats. L'approche de l'unité de recherche utilise le milieu comme source d'information pour développer des méthodes de mesure, en exploitant notamment les concepts de bio-capteurs et de bio-indicateurs. L'agrégation des variables en indicateurs globaux et l'utilisation de modèles comme outils de surveillance de l'environnement figurent également parmi les originalités de la démarche. [less ▲]

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See detailPurification of soybean lipoxygenase isoenzyme-1 and characterization of its inhibition by 13-hydroperoxides.
Fauconnier, Marie-Laure ULg; Marlier, M.

in Grasas y Aceites (1996), 47(4), 242-246

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See detailLe clonage par transfert de noyau dans l'espece bovine: resultats et perspectives.
Ectors, Fabien ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(12), 493-9

A all in vitro cloning technique was developed in which the reconstituted embryos from the first cycle nuclear transfer (cloning) were used as blastomere donor for the second cycle nuclear transfer ... [more ▼]

A all in vitro cloning technique was developed in which the reconstituted embryos from the first cycle nuclear transfer (cloning) were used as blastomere donor for the second cycle nuclear transfer (recloning). Such method permitted to produce 14.5% of morulae and 14.9% of blastocysts after the first and second cycles of nuclear transfer, respectively. The rates of birth obtained after transfer of such embryos were 21.4% et 20.8% for first and second cycles respectively, corresponding to 6 et 5 calves for 28 et 24 transferred embryos. Unfortunately, gestation pathologies and an increase of birth weights were observed. It seems that the in vitro presence of gametes and/or embryos may be responsible of an alteration in the control of gene expression. [less ▲]

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See detailL'immaginario lunare
Curreri, Luciano ULg

in La Battana (1996), 120

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See detail"Le plus subtil ouvrir de monde" Godefroid de Huy,orfèvre mosan
George, Philippe ULg

in Cahiers de Civilisation Médiévale (1996), XXXIX

http://www.persee.fr/web/revues/home/prescript/article/ccmed_0007-9731_1996_num_39_156_2659

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See detailHypertension artérielle et antagonistes du récepteur de l'angiotensine II
Krzesinski, Jean-Marie ULg; Turatzinse, L.; Rorive, Georges ULg

in Médecine et Hygiène (1996), 2127

Dans l'hypertension artérielle et la décompensation cardiaque, les inhibiteurs de l'enzyme de conversion constituent un outil thérapeutique important mais, parfois, au prix de certains effets secondaires ... [more ▼]

Dans l'hypertension artérielle et la décompensation cardiaque, les inhibiteurs de l'enzyme de conversion constituent un outil thérapeutique important mais, parfois, au prix de certains effets secondaires (par exemple, la toux). De nouvelles perspectives de contrôle du système rénine angiotensine-aldostérone se profilent à l'horizon avec l'avènement des antagonistes des récepteurs de l'angiotensine Il. Le losartan est lepremier agent de cette famille, de nature non peptidique et actif par voie orale. Sa longue durée d'action permet une seule administration par jour. Cet agent bloque tous les effets connus de l'angiotensine II par une action au niveau des récepteurs appelés AT1. Au vu des premiers résultats publiés, il constitue un concurrent des inhibiteurs de l'enzyme de conversion dans l'hypertension et la décompensation cardiaque. [less ▲]

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See detailSeabirds mortality during the 1992-1993 winter along the Belgian coast
Jauniaux, Thierry ULg; Brosens, L.; Farnir, Frédéric ULg et al

in Annales de Médecine Vétérinaire (1996), 140(3), 149-

During the 1992-1993 133 seabirds found on Belgian beaches were necropsied. Most frequent species were the guillemot (Uria aalge), the oystercatcher (Haematopus ostralegus), the kittiwake (Rissa ... [more ▼]

During the 1992-1993 133 seabirds found on Belgian beaches were necropsied. Most frequent species were the guillemot (Uria aalge), the oystercatcher (Haematopus ostralegus), the kittiwake (Rissa tridactyla), the razorbill (Alca torda) and the herring gull (Larus argentatus). The three main observations were, in decreasing order, cachexia, acute and hemorrhagic gastroenteritis, and oil contamination of plumage and intestinal tract. The pelagic origin of seabirds was associated with all 3 observations; oil contamination was associated with acute gastro-enteritis and cachexia and, finally, the immature character was associated with cachexia. A hypothetical mechanism of death would be oiled pelagic seabirds that become cachectic and die of acute gastroenteritis. It is unlikely that seabirds act as a reservoir for bacteria, that were only occasionally identified in our material. Therefore, it appears that infectious agents play a minor role in seabirds stranding. [less ▲]

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See detailIpriflavone in prevention and treatment of postmenopausal and senile osteoporosis
Reginster, Jean-Yves ULg

in Osteoporosis News (1996), 4

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See detailChemical Composition Of Pea Fibre Isolates And Their Effect On The Endogenous Amino Acid Flow At The Ileum Of The Pig
Leterme, Pascal; Thewis, André ULg; Van leeuwen, Piet et al

in Journal of the Science of Food and Agriculture (1996), 72(1), 127-134

Pea starch, hulls and cotyledon inner fibres, isolated from pea seeds, were incorporated in N-free diets, on a NDF-content basis, in order to study their effect on the ileal endogenous amino acid (AA ... [more ▼]

Pea starch, hulls and cotyledon inner fibres, isolated from pea seeds, were incorporated in N-free diets, on a NDF-content basis, in order to study their effect on the ileal endogenous amino acid (AA) excretion in the growing pig. Maize starch and wood cellulose were selected as references. The inner fibrecontaining diet was also supplemented with enzymatically hydrolysed casein (EHC) in order to test the peptide alimentation method on a diet containing a fibre source with a high water-holding capacity (WHC = 10.9 g water g-' DM). The fibres were also analysed by different methods (crude fibre, NDF, ADF, enzymatic-gravimetric method, Englyst method). The fibre content of the inner fibre fraction varied widely from one method to another and ranged from 109 g crude fibre to 480 g AOAC fibre kg-' DM. Compared to the 'maize starch + wood cellulose' diet (11.0 g AA excreted kg-' DM intake), pea starch had no effect on ileal AA losses (9.6 g), whereas pea hulls slightly increased them (14.2 g). The AA excretion dramatically increased with the incorporation of inner fibres (28.0 g), because of their very high WHC. The addition of EHC increased the output (48.0 g) further, at a level that can hardly be explained only by an increase of the endogenous secretions. The results suggest that the NDF content of grain legume products is not indicative of their effect on the ileal endogenous AA losses in pigs and that the physiological effects of fibres along the gastrointestinal tract are due to both their chemical and physical properties. [less ▲]

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See detailModelling irregularly sampled profiles of nonnegative dog triglyceride responses under different distributional assumptions
Lambert, Philippe ULg

in Statistics in Medicine (1996), 15

General methodology for modelling series of non-negative data observed at unequally spaced times is developed. The parameterization enables both the importance of the serial association, as well the order ... [more ▼]

General methodology for modelling series of non-negative data observed at unequally spaced times is developed. The parameterization enables both the importance of the serial association, as well the order of this dependence to be expressed. An example is given where the effects of three fibre based diets on dog triglyceride profiles are analysed and compared. Many different types of models based on common distributions such as the normal, exponential, gamma, Weibull and log-normal observations are presented. Comparison of possibly non-nested models fitted on the same data set is made using the Akaike criterion. [less ▲]

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See detailParticle Production in a Hadron Collider Rapidity Gap: The Higgs Case
Cudell, Jean-René ULg; Hernandez, Oscar F

in Nucl. Phys. (1996), B471

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See detailFréquence et importance du charriage dans des rivières à charge de fond graveleuse
Petit, François ULg; Pauquet, A.; Pissart, Albert ULg

in Géomorphologie : Relief, Processus, Environnement (1996)

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See detailExpansive benign lesions: treatment by laser.
Smets, Mireille; NISOLLE, Michelle ULg; Bassil, Salim et al

in European Journal of Obstetrics and Gynecology (1996), 65(1), 101-5

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ... [more ▼]

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ablation using the Nd-YAG laser and the advantages of the preoperative use of GnRH agonist therapy. They report their results in a series of 746 patients treated for meno-metrorrhagia (366 cases of myomectomy and 380 cases of endometrial ablation). [less ▲]

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See detailL'endotoxémie dans l'espèce équine. 1ère partie: étiologie et physiopathologie.
Amory, Hélène ULg

in Pratique Vétérinaire Equine (1996), 28

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See detailLa géographie au service du développement local. Le bilan du Colloque de Liège (16-18 novembre 1995) de l'Association de Géographes Français
Merenne-Schoumaker, Bernadette ULg

in Cahiers de Géographie du Quebec (1996), 40(111), 479-484

Summary of a symposium held in Liege from 16 to 18 November 1996 on the theme of local development

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See detailRetard neuromoteur et neuropsychologique: critères de recours à une prise en charge spécialisée
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia et al

in Percentile (1996), .(3), 103-107

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See detailStructure-activity relationships in platelet-activating factor (PAF).7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonist activity
Le Texier, Laurence; Favre, Edith; Redeuilh, Catherine et al

in Journal of Lipid Mediators and Cell Signalling (1996), 13

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See detailCardio-respiratory adjustments and arterial blood gases in exercising horses in crisis and in clinical remission
Art, Tatiana ULg; Anciaux, N.; Duvivier, H. et al

in Pferdeheilkunde (1996), 12(4), 717-718

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See detailPlasma Concentration of Estradiol Following Transdermal Administration of Systen 50 or Menorest 50
Reginster, Jean-Yves ULg; Albert, Adelin ULg; Deroisy, Rita ULg et al

in Scandinavian Journal of Rheumatology. Supplement (1996), 103

Circulating levels of 17 beta estradiol (E2) following the administration of fixed doses of E2, show a great variability in kinetics depending upon the product administrated, the routes of administration ... [more ▼]

Circulating levels of 17 beta estradiol (E2) following the administration of fixed doses of E2, show a great variability in kinetics depending upon the product administrated, the routes of administration, and the interindividual variations in absorption and metabolism. This might have important implications both in terms of tolerance and effectiveness. Two new forms of transdermal E2 (SYSTEN Cilag and MENOREST Rhone-Poulenc Rorer) have been recently accepted in Europe for the treatment of climacteric symptoms. The present study was undertaken to compare the pharmacokinetic characteristics of plasma E2 profile under these two drugs. It was carried out in 30 healthy postmenopausal volunteers according to good clinical practice after informed consent, as a single blind, randomised, cross-over study during the classical wearing period of 4 days. Plasma E2 concentration was determined 24 hours before, 1/2 hour before and then 2, 4, 8, 12, 24, 48, 72, 84, 96 hours after the first patch administration. E2 measurement was performed using a specific direct radioimmunoassay developed in the FRH laboratories. The main criteria for this method were an intraassay coefficient of variation (CV) less than 6%, an interassay CV less than 8% in a concentration range of 15-140 pg/ml and a quantitative detection limit (LOQ) of 2.7 pg/ml with a 20% CV. The following kinetic parameters were analysed: C(max), C(mean), C96 and MRT. The bioequivalence was assessed by analysis of variance of C(max), C(mean), C96 and AuC after logarithmic transformation, complemented by Westlake test (95%). Data show that these two products are identical in terms of C(max) but C(mean), C96 and AuC are statistically greater when MENOREST 50(R) is administered; furthermore, E2 levels decrease more rapidly and more deeply with SYSTEN 50 than MENOREST 50. The differences of pharmacokinetic profiles after administration of two different forms of the same dose of 50 micrograms transdermal 17 beta estradiol might have important medical consequences. [less ▲]

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See detailThe current situation of wild mammals in Belgium: an outline
Libois, Roland ULg

in Hystrix: the Italian Journal of Mammalogy (1996), 8(1-2), 35-41

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better ... [more ▼]

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better understanding of the current status of the different species. Conservation measures were olso proposed to the political authorities who thereafter edicted a legal protection of the most vulnerable species. Unfortunately, habitat protection is rather unachieved and the situation of the most endangered species is still getting worse. [less ▲]

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See detailComposition of the essential oil of Piper acutifolium Ruiz. and Pav. from Peru.
Lognay, Georges ULg; Bouxin, P.; Marlier, M. et al

in Journal of Essential Oil Research (1996), 8(6),

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See detailInfection of cattle with Yersinia enterocolitica O:9 a cause of the false positive serological reactions in bovine brucellosis diagnostic tests.
Weynants, V.; Tibor, A.; Denoel, P. A. et al

in Veterinary Microbiology (1996), 48(1-2), 101-12

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of ... [more ▼]

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of brucellosis was reported in these animals and no Brucella abortus strains were isolated. After two years, no brucellosis outbreak was registered in all of the herds concerned. On this basis, all the serological reactions observed were classified as false positive. An ELISA using Yersinia Outer membrane Proteins (YOPs) as antigens was developed in order to discriminate between a Yersinia enterocolitica O:9 infection and a Brucella abortus infection. Antibodies against YOPs were detected in sera from Y. enterocolitica O:9 experimentally infected cattle (n = 4) but not in sera from B. abortus experimentally infected cattle (n = 4). In a field study, 66.7% of the 174 serum samples from cattle presenting false positive serological reactions showed anti-YOPs antibodies whereas only 10% of 454 sera, classified negative by the brucellosis screening tests, showed anti-YOPs antibodies. Our results suggest that infections with Y. enterocolitica O:9 may cause false positive reactions in brucellosis testing. [less ▲]

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See detailManifestaciones cardiovasculares en el SIDA
Valdes, E. F.; Rostello, E.; Villanueva, H. R. et al

in Prensa Medica Argentina (1996), 83

Cardiovascular complications in acquired immunodeficiency syndrome. AIDS miocardiopathy has been described since 1983. Physiopathologic events leading to AIDS myocardiopathy are largely unknown: viral ... [more ▼]

Cardiovascular complications in acquired immunodeficiency syndrome. AIDS miocardiopathy has been described since 1983. Physiopathologic events leading to AIDS myocardiopathy are largely unknown: viral miocardiopathy, cytokines induced lesions, nutritional status, microvascular and ischemic miocadiopathy have been suspected. We describe a consecutive series of 50 patients (43 males, 7 women) with HIV infection and severe immunodepression (CD4<200/ml) that had clinical, ECG and echocardiographic evaluation. There were 24 drug addicted patients, 17 homosexual patients, and 10 heterosexuals. Some of these patients had the following opportunistic infections: tuberculosis (n=20), Pneumocystis carinii (n=9), Criptocococis (n=9), oropharyngeal candidosis (n=5), toxoplasmosis (n=5), histoplasmosis (n=1) and Kaposi’s sarcoma (n=2). After clinical evaluation 15/50 patients had some kind of cardiovascular complication: 6 patients had congestive heart failure, 5 patients presented with pericardial effusion, one patient has a reversible cardiac arrest, and one patient had pulmonary valvular endocarditis. After Doppler echocardiographic evaluation (according to the American echocardiography association), we found 20 patients with left ventricular diastolic dysfunction, 9 patients with right ventricular diastolic dysfunction and 6 patients with left ventricular systolic dysfunction. In conclusion, our series found left diastolic dysfunction in nearly 40 % of cases and cardiavasular events (pericarditis, heart congestive failure, arrhythmias) in 26% of cases. Cardiovascular complications have prognostic implications in AIDS and shoul be early detected. Further pathological and immunohistochemical studies are needed to clarify the phyiopathological etiologies in AIDS miocardiopathy. [less ▲]

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