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See detailFamily size and optimal income taxation
Cremer, Helmuth; Dellis, Arnaud; Pestieau, Pierre ULiege

in Journal of Population Economics (2003), 16(1), 37-54

This paper studies the role of family size in the design of optimal income taxation. We consider a second best setting where the government observes the number of children and the income of the parents ... [more ▼]

This paper studies the role of family size in the design of optimal income taxation. We consider a second best setting where the government observes the number of children and the income of the parents but not their productivity. With a linear tax schedule the marginal tax rate is shown to decrease with the number of children, while the relationship between the demogrant and family size appears to be ambiguous. With two ability levels, optimal non-linear income tax implies zero marginal tax rates for the higher ability parents; low ability parents have positive marginal tax rates that decrease with family size. [less ▲]

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See detailLong-term efficacy of risedronate: a 5-year placebo-controlled clinical experience
Sorensen, O. H.; Crawford, G. M.; Mulder, H. et al

in BONE (2003), 32(2), 120-126

Limited placebo-controlled data are available to assess the long-term fracture efficacy of bisphosphonates. In order to determine the effects of 5 years of risedronate treatment, we extended a 3-year ... [more ▼]

Limited placebo-controlled data are available to assess the long-term fracture efficacy of bisphosphonates. In order to determine the effects of 5 years of risedronate treatment, we extended a 3-year, placebo-controlled vertebral fracture study in osteoporotic women for an additional 2 years; women who entered the extension study continued to receive 5 mg risedronate or placebo according to the original randomization, with maintenance of blinding. End points included vertebral and nonvertebral fracture assessments, bone mineral density measurements, and changes in biochemical markers of bone turnover. A total of 265 women (placebo, 130; 5 mg risedronate, 135) entered the study extension and 220 (83%) completed the additional 2 years. Fracture results observed in the study extension were consistent with those observed in the first 3 years. The risk of new vertebral fractures was significantly reduced with risedronate treatment in years 4 and 5 by 59% (95% confidence interval, 19 to 79%, P = 0.01) compared with a 49% reduction in the first 3 years. Rapid and significant decreases in markers of bone turnover observed in the first 3 years were similarly maintained in the next 2 years of treatment. Increases in spine and hip bone mineral density that occurred in the risedronate group during the first 3 years were maintained or increased with a further 2 years of treatment. The mean increase from baseline in lumbar spine BMD over 5 years was 9.3% (P < 0.001). This study demonstrates that the effects of risedronate over 3 years on vertebral fracture and BMD are maintained with a further 2 years of treatment. (C) 2003 Elsevier Science (USA). All rights reserved. [less ▲]

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See detailResults of exercise testing at a mean age of 10 years after neonatal arterial switch operation.
Hovels-Gurich, H. H.; Kunz, D.; Seghaye, Marie-Christine ULiege et al

in Acta paediatrica (Oslo, Norway : 1992) (2003), 92(2), 190-6

AIM: This prospective follow-up study investigated long-term exercise capacity at a mean age of 10 y after neonatal arterial switch operation for transposition of the great arteries in a large group of ... [more ▼]

AIM: This prospective follow-up study investigated long-term exercise capacity at a mean age of 10 y after neonatal arterial switch operation for transposition of the great arteries in a large group of homogeneous unselected children. METHODS: 56 asymptomatic children, aged 7.9-14.3 y (10.5 +/- 1.6, mean +/- SD), were examined with respect to exercise tolerance, electrocardiographic (ECG) response and activity of biochemical markers for myocardial injury. The protocol included standard electrocardiography, M-mode and two-dimensional echocardiography at rest, a Bruce walking treadmill test to voluntary exhaustion, and determination of cardiac troponin I and T, creatine kinase and myoglobin from venous blood samples at rest and 4 h after exercise. Heart rate, blood-pressure response to exercise stress and endurance time were compared with published results of age-matched normal children. RESULTS: 54 patients (96.4%) had normal exercise capacity; a reduction in 2 patients was not due to cardiac disease. Heart rate and systolic blood pressure rose significantly between rest and peak exercise and did not differ from normal controls, whereas diastolic blood pressure was lower. ECG remained normal at rest and on exercise in 54 children (96.4%). Serum values of cardiac troponin I and T, creatine kinase and myoglobin were normal at rest and after exercise in all patients. CONCLUSION: The study demonstrates excellent long-term exercise capacity after neonatal arterial switch operation. Exercise testing is a useful and non-invasive screening method to detect patients with clinically relevant exercise-induced myocardial ischaemia and should be routinely performed in growing patients. [less ▲]

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See detailPatient assessment using standardized bone mineral density values and a national reference database: implementing uniform thresholds for the reimbursement of osteoporosis treatments in Belgium
Boonen, S.; Kaufman, J. M.; Reginster, Jean-Yves ULiege et al

in Osteoporosis International (2003), 14(2), 110-115

Dual-energy X-ray absorptiometry (DXA) devices from the three main manufacturers provide different bone mineral density (BMD) values, due in part to technical differences in the algorithms for bone ... [more ▼]

Dual-energy X-ray absorptiometry (DXA) devices from the three main manufacturers provide different bone mineral density (BMD) values, due in part to technical differences in the algorithms for bone mineral content (BMC) and area measurements and in part to the use of different manufacturer-derived reference databases. As a result, significant differences exist between Hologic, Lunar and Norland systems in the reported young normal standard deviation scores or T-scores. In a number of European countries, including Belgium, a T-score below -2.5 is one of the key criteria for reimbursement of osteoporosis treatments. This paper addresses the first attempt to implement a nationwide, uniform expression of BMD in patients, in order to harmonize drug reimbursement. To this end, measures were taken to implement a uniform expression of BMD in Belgian patients, by converting each manufacturer's absolute BMD to standardized BMD (sBMD) values and by establishing a single national reference range. [less ▲]

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See detailMorphological study of magnesium hydroxide nanoparticles precipitated in dilute aqueous solution
Henrist, Catherine ULiege; Mathieu, J. P.; Vogels, C. et al

in Journal of Crystal Growth (2003), 249(1-2), 321-330

Among other applications, magnesium hydroxide is commonly used as a flame-retardant filler in composite materials, as well as a precursor for magnesium oxide refractory ceramic. The microstructure of the ... [more ▼]

Among other applications, magnesium hydroxide is commonly used as a flame-retardant filler in composite materials, as well as a precursor for magnesium oxide refractory ceramic. The microstructure of the powder is of prime importance in both technical applications. The influence of synthesis parameters on the morphological characteristics of magnesium hydroxide nanoparticles precipitated in dilute aqueous medium was studied. Several parameters were envisaged such as chemical nature of the base precipitant, type of counter-ion, temperature and hydrothermal treatment. Special attention was given to the obtaining of platelet-shaped, nanometric and de-agglomerated powders. The powders were characterized in terms of particle size distribution, crystal habits, morphology and ability to be redispersed in water. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption and laser diffusion analyses were used for this purpose. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailIndolomonoterpenic alkaloids from Strychnos icaja roots
Philippe, Geneviève ULiege; De Mol, Patrick ULiege; Zeches-Hanrot, M. et al

in Phytochemistry (2003), 62(4), 623-629

In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos ... [more ▼]

In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos nux-vomica, pseudostrychnine, already found in the leaves of the plant, a new bisindolic alkaloid, named strychnogucine C, and the first naturally occurring trimeric indolomonoterpenic alkaloid: strychnohexamine. This latter trimeric alkaloid presented an antiplasmodial activity against the FCA Plasmodium falciparum line near I muM. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailLire ou ne pas lire : état de la question
Baye, Ariane ULiege; Lafontaine, Dominique ULiege; Vanhulle, Sabine

in Cahiers du Centre de Lecture publique de la Communauté française (2003), 4

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See detailMineralogical gradients associated with alvinellids at deep-sea hydrothermal vents
Zbinden, M.; Le Bris, N.; Compère, Philippe ULiege et al

in Deep-Sea Research Part I-Oceanographic Research Papers (2003), 50(2), 269-280

Alvinella pompejana and Alvinella caudata live in organic tubes on active sulphide chimney walls at deep-sea hydrothermal vents. These polychaete annelids are exposed to extreme thermal and chemical ... [more ▼]

Alvinella pompejana and Alvinella caudata live in organic tubes on active sulphide chimney walls at deep-sea hydrothermal vents. These polychaete annelids are exposed to extreme thermal and chemical gradients and to intense mineral precipitation. This work points out that mineral particles associated with Pompeii worm (A. pompejana and A. caudata) tubes constitute useful markers for evaluating the chemical characteristics of their micro-environment. The minerals associated with these worm tubes were analysed on samples recovered from an experimental alvinellid colony, at different locations in the vent fluid-seawater interface. Inhabited tubes from the most upper and lower parts of the colony were analysed by light and electron microscopies, X-ray microanalysis and X-ray diffraction. A change was observed from a Fe-Zn-S mineral assemblage to a Zn-S assemblage at the millimeter scale from the outer to the inner face of a tube. A similar gradient in proportions of minerals was observed at a decimeter scale from the lower to the upper part of the colony. The marcasitc/pyrite ratio of iron disulphides also displays a steep decrease along the few millimeters adjacent to the external tube surface. The occurrence of these gradients indicates that the microenvironment within the tube differs from that outside the tube, and suggests that the tube wall acts as an efficient barrier to the external environment. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailOn functional and structural heterogeneity of VIM-type metallo-beta-lactamases
Docquier, J. D.; Lamotte-Brasseur, J.; Galleni, Moreno ULiege et al

in Journal of Antimicrobial Chemotherapy (2003), 51(2), 257-266

The VIM metallo-beta-lactamases are emerging resistance determinants, encoded by mobile genetic elements, that have recently been detected in multidrug-resistant nosocomial isolates of Pseudomonas ... [more ▼]

The VIM metallo-beta-lactamases are emerging resistance determinants, encoded by mobile genetic elements, that have recently been detected in multidrug-resistant nosocomial isolates of Pseudomonas aeruginosa and other Gram-negative pathogens. In this work a T7-based expression system for overproduction of the VIM-2 enzyme by Escherichia coli was developed, which yielded similar to80 mg of protein per litre of culture. The enzyme was mostly released into the medium, from which it was recovered at >99% purity by an initial ammonium sulphate precipitation followed by two chromatography steps, with almost 80% efficiency. Determination of kinetic parameters of VIM-2 under the same experimental conditions previously used for VIM-1 (the first VIM-type enzyme detected in clinical isolates, which is 93% identical to VIM-2) revealed significant differences in K-m values and/or turnover rates with several substrates, including penicillins, cephalosporins and carbapenems. Compared with VIM-1, VIM-2 is more susceptible to inactivation by chelators, indicating that the zinc ions of the latter are probably more loosely bound. These data indicated that at least some of the amino acid differences between the two proteins have functional significance. Molecular modelling of the two enzymes identified some amino acid substitutions, including those at positions 223, 224 and 228 (in the BBL numbering), that could be relevant to the changes in catalytic behaviour. [less ▲]

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See detailEffect of intra-operative magnesium sulphate on pain relief and patient comfort after major lumbar orthopaedic surgery
Levaux, Christine ULiege; Bonhomme, Vincent ULiege; Dewandre, Pierre-Yves et al

in Anaesthesia (2003), 58(2), 131-135

The effects of intra-operative magnesium sulphate on pain relief after major lumbar surgery were investigated in 24 patients. Patients were randomly allocated to receive either an infusion of 50 mg x kg ... [more ▼]

The effects of intra-operative magnesium sulphate on pain relief after major lumbar surgery were investigated in 24 patients. Patients were randomly allocated to receive either an infusion of 50 mg x kg(-1) magnesium sulphate or an equivalent volume of saline at induction of anaesthesia. Anaesthesia was induced with propofol and remifentanil. Tracheal intubation was facilitated using rocuronium. Maintenance was achieved with remifentanil and sevoflurane in nitrous oxide/ oxygen. Intra-operative monitoring included standard equipment and neuromuscular transmission. During surgery, neuromuscular block recovery was longer in the magnesium group. Postoperative opioid consumption and pain scores were lower in the magnesium group. The first night's sleep and the global satisfaction scores were better in the magnesium group. The results of the study support magnesium sulphate as a useful adjuvant for postoperative analgesia after major lumbar surgery. [less ▲]

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See detailStrontium ranelate: A new paradigm in the treatment of osteoporosis
Reginster, Jean-Yves ULiege; Deroisy, Rita ULiege; Jupsin, Isabelle ULiege

in Drugs of Today (2003), 39(2), 89-101

Not one of the currently available medications has, so far, unequivocally demonstrated its ability to fully prevent the occurrence of new vertebral or peripheral osteoporotic fractures once osteoporosis ... [more ▼]

Not one of the currently available medications has, so far, unequivocally demonstrated its ability to fully prevent the occurrence of new vertebral or peripheral osteoporotic fractures once osteoporosis is established. Therefore, several new therapies are currently under development to optimize the risk/benefit ratio of osteoporosis treatment. Strontium ranelate is composed of an organic moiety (ranelic acid) and of two atoms of stable nonradioactive strontium. In vitro, strontium ranelate increases Collagen and noncollagenic proteins synthesis by mature osteoblast enriched cells. The effects of strontium ranelate on bone formation were confirmed as strontium ranelate enhanced pre-osteoblastic cell replication. The stimulation by strontium ranelate of the replication of osteoprogenitor cell and collagen, as well as noncollagenic protein synthesis in osteoblasts, provides substantial evidence to categorize strontium ranelate as a bone-forming agent. In the isolated rat osteoclast assay, a pre-incubation of bone slices with strontium ranelate induced a dose-dependent inhibition of the bone resorbing activity of treated rat osteoclast. Strontium ranelate also dose-dependently inhibited, in a chicken bone marrow culture, the expression of both carbonic anhydrase 11 and the (x-subunit of the vitronectin receptor. These effects showing that strontium ranelate significantly affects bone resorption due to a direct and/or matrix-mediated inhibition of osteoclast activity and also inhibits osteoclasts differentiation, are compatible with the profile of an anti-resorptive drug. In normal rats, administration of strontium ranelate induces an improvement in the mechanical properties of the humerus and/or the lumbar vertebra associated with a commensurate increase in bone dimension, shaft and volume. Strontium ranelate was administered in 160 early postmenopausal women, in a 24-month, double-blind, placebo-controlled, prospective randomized study. Daily oral dose of 125 mg, 500 mg and 1 g of strontium ranelate were compared with a placebo. At the conclusion of the study, the percent variation of lumbar-adjusted bone mineral density from baseline was significantly different in the group receiving 1 g/day of strontium ranelate compared with placebo (+1.41% vs. -0.98%, respectively). Increase in total hip and neck bone mineral density averages, respectively, 3.2% and 2.5%. Strontium ranelate does not induce any significant adverse reaction compared with those observed in women receiving a placebo for the same duration. In a phase 11 study, the effect of strontium ranelate in postmenopausal women with vertebral osteoporotic fractures was assessed during a double-blind, placebo-controlled trial. Doses of 500 mg, 1 g and 2 g daily of strontium ranelate or placebo were given to 353 Caucasian women with prevalent osteoporosis. At the conclusion of this 2-year study, the annual increase in lumbar-adjusted bone mineral density of the group receiving 2 g of strontium ranelate was +2.97%. This result was significantly different compared with placebo. A significant increase in bone alkaline phosphatase and, over a 6-month period, a significant decrease in urinary-pyridium crosslinks (NTX) were evidenced. During the second year of treatment, the dose of 2 g was associated with a 44% reduction in the number of patients experiencing a new vertebral deformity. Bone histomorphometry showed no mineralization defects. The same percentage of withdrawals following an adverse effect was observed for patients receiving placebo and for those receiving 2 g of strontium ranelate. The compound was further investigated in a large phase III program that included two extensive trials for the treatment of severe osteoporosis, one assessing the effects of strontium ranelate on the risk of vertebral fractures (SOTI) and one evaluating its effects on peripheral (nonspinal) fractures (TROPOS). The primary analysis of the SOTI study, evaluating the effect of 2 g of strontium ranelate on vertebral fracture rates, revealed a 41% reduction in the relative risk of experiencing a first new vertebral fracture with strontium ranelate, throughout the 3-year study, compared with placebo. The TROPOS study, showed a significant (p = 0.05) reduction in the relative risk of experiencing a first non-vertebral fracture in the group treated with strontium ranelate throughout the 3-year study compared with placebo in the intention-to-treat population. A 41% reduction in the relative risk of experiencing a hip fracture was demonstrated in the per protocol population. All these results imply that strontium ranelate is a new, effective and safe treatment for vertebral and nonvertebral osteoporosis, with a unique mode of action. (C) 2003 Prous Science. All rights reserved. [less ▲]

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See detailA new proposal of a simple model for the lateral-torsional buckling of unrestrained steel I-beams in case of fire: experimental and numerical validation
Vila Real, Paolo; Piloto, Paolo; Franssen, Jean-Marc ULiege

in Journal of Constructional Steel Research (2003), 59(2), 179-199

The behaviour of Steel I-Beams exhibiting lateral-torsional buckling at elevated temperature has been studied by means of experimental and numerical analysis. The authors in an earlier paper have ... [more ▼]

The behaviour of Steel I-Beams exhibiting lateral-torsional buckling at elevated temperature has been studied by means of experimental and numerical analysis. The authors in an earlier paper have presented an analytical formula for the buckling resistance moment in the fire design situation. This new proposal, different from the actual proposal of the Eurocode 3 Part 1.2 has been validated in this work by comparison with the results from a set of 120 experimental and numerical tests performed on IPE 100 beams, submitted to temperatures varying from room temperature to 600 degreesC. The numerical simulations have been based on the measured geometrical dimensions of the cross-sections, the longitudinal imperfections, i.e. the out of straightness of the beams, the residual stresses and the yield strength. The Eurocode simple model promotes ultimate loads that depend mainly on the non-dimensional slenderness of the beams. The analytical results provided by the Eurocode 3, for a certain range of the slenderness, appear to be unsafe when compared with the numerical and experimental results. It is shown that the new proposal is safer than the Eurocode 3 formulas. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailTraitement hormonal apres cancer du sein. Oui ... ou non?
Foidart, Jean-Michel ULiege; Desreux, Joëlle ULiege; Lifrange, Eric ULiege et al

in Revue Médicale de Liège (2003), 58(2), 77-82

Clinical and experimental studies indicate that combined unique conjugated estrogens and medroxyprogesterone acetate moderately increase the risk of breast cancer in postmenopausal women. Classically ... [more ▼]

Clinical and experimental studies indicate that combined unique conjugated estrogens and medroxyprogesterone acetate moderately increase the risk of breast cancer in postmenopausal women. Classically, hormone replacement therapy is contra-indicated in women with a past history of breast cancer due to the fear of recurrence. However, these postmenopausal patients complain about hot flushes and adjuvant hormonal therapies (such as aromatase inhibitors, SERMs and Tamoxifen...) aggravate their symptoms. Observational studies and their meta-analyses do not show a deleterious effect but rather a beneficial impact of hormone replacement therapy among women with a past history of breast cancer. We summarise all these studies and their biological, clinical and epidemiological interpretations. We conclude that short term hormone replacement therapy is safe among those women requesting a replacement therapy after complete information. It is however advisable to conclude definitely only when prospective randomised trials with estradiol or tibolone (a promising alternative) will be available. Such ongoing studies will allow to conclude definitely the possible benefits and risks of hormone replacement therapy among patients with a past history of breast cancer. [less ▲]

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See detailLine profile variability in the spectra of Oef stars. I. BD + 60deg 2522
Rauw, Grégor ULiege; De Becker, Michaël ULiege; Vreux, Jean-Marie ULiege

in Astronomy and Astrophysics (2003), 399

We report the analysis of a long term observing campaign designed to monitor the spectroscopic variability of the Oef star BD +60deg 2522. We find that the double-peaked He {II} lambda 4686 emission line ... [more ▼]

We report the analysis of a long term observing campaign designed to monitor the spectroscopic variability of the Oef star BD +60deg 2522. We find that the double-peaked He {II} lambda 4686 emission line undergoes strong profile variability on time scales of 2-3 day. However, the time scale as well as the pattern of these variations turn out to be epoch dependent and the phenomenon is thus most likely not ruled by a single stable clock. On the other hand, the absorption lines in the spectrum of BD +60deg 2522 display line profile variability on time scales of a few hours that might be related to non-radial pulsations. We tentatively propose that the beating of several non-radial pulsation modes triggers transient large-scale density perturbations in a confined stellar wind that produce the 2-3 day time scale variability. [less ▲]

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See detailLa mesure du débit de filtration glomérulaire en clinique quotidienne
Delanaye, Pierre ULiege; Chapelle, Jean-Paul ULiege; Ferir, Anne-Marie et al

in Revue Médicale de Liège (2003), 58(2), 95-100

Glomerular filtration rate (GFR) is the most frequently used parameter to evaluate the renal function. GFR may be estimated with serum creatinine, creatinine clearance based on 24 hours urine collection ... [more ▼]

Glomerular filtration rate (GFR) is the most frequently used parameter to evaluate the renal function. GFR may be estimated with serum creatinine, creatinine clearance based on 24 hours urine collection or Cockcroft formula. All these methods have bias. Other approaches have thus been proposed. The limitations and advantages of isotopic methods and recent mathematical approaches (MDRD formula) are reviewed. [less ▲]

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See detailDeficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice.
Lijnen, Roger; Demeulemeester, Diego; Van Hoef, B. et al

in Thrombosis and Haemostasis (2003), 89(2), 249-255

Tissue inhibitor of matrix metalloproteinase-1 deficient (TIMP-1(-/-)) mice and wild-type (TIMP-1(+/+)) controls were kept on a standard (SFD) or a high fat diet (HFD) for 15 weeks. At the time of ... [more ▼]

Tissue inhibitor of matrix metalloproteinase-1 deficient (TIMP-1(-/-)) mice and wild-type (TIMP-1(+/+)) controls were kept on a standard (SFD) or a high fat diet (HFD) for 15 weeks. At the time of sacrifice, TIMP-1(-/-) mice on HFD had a significantly lower body weight (29 +/- 1.5 versus 41 +/- 1.8 g, p <0.005), and significantly less subcutaneous (0.81 +/- 0.19 versus 1.78 +/- 0.21 g, p <0.05) and gonadal (0.87 +/- 0.17 versus 1.85 +/- 0.18 g, p <0.005) fat mass. These differences were much less pronounced for mice on SFD. On HFD but not on SFD, adipocyte diameters were significantly lower in the adipose tissue of TIMP-1(-/-) mice. Plasma leptin levels in TIMP-1(-/-) mice on HFD were significantly lower as compared to TIMP-1(+/-) mice, and strongly correlated with adipose tissue mass for both genotypes. Staining with an endothelial cell specific lectin revealed a significantly higher blood vessel density, larger stained area and vessel size in adipose tissue of TIMP-1(-/-) mice on HFD. This difference disappeared after normalization to the adipocyte number, suggesting that it does not represent a true enhancement of angiogenesis. Thus, in a murine model of nutritionally induced obesity, TIMP-1 promotes adipose tissue development. [less ▲]

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See detail"Dermato-couture": points de suture utiles en chirurgie dermatologique
Jacquemin, Gael; Richert, Bertrand ULiege; de LA BRASSINNE, Michel ULiege

in Revue Médicale de Liège (2003), 58(2), 88-94

Dermatologists performing skin surgery mostly use the square knot. Other underused or even forgotten suturing techniques may still be helpful in some instances. We shall emphasize some simple techniques ... [more ▼]

Dermatologists performing skin surgery mostly use the square knot. Other underused or even forgotten suturing techniques may still be helpful in some instances. We shall emphasize some simple techniques such as the horizontal mattress suture, the “cross stitch”, the “corner stitch” (half buried mattress suture), the buried dermal suture, the buried vertical mattress suture, the continuous mattress suture and the running intradermal suture. In given circumstances, all of them may improve suturing and promote healing. Technical aspects, advantages and disadvantages of each type of suture will be briefly described. [less ▲]

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See detailRadiative lifetime and oscillator strength determinations in SmIII
Biémont, Emile ULiege; Garnir, Henri-Pierre ULiege; Litzen, U. et al

in Astronomy and Astrophysics (2003), 399(1), 343-349

Radiative lifetimes of 6 levels belonging to the 4f(5)((6)Hdegrees, (6)Fdegrees)5d configuration of Sm III have been measured for the first time using a time-resolved laser-induced fluorescence technique ... [more ▼]

Radiative lifetimes of 6 levels belonging to the 4f(5)((6)Hdegrees, (6)Fdegrees)5d configuration of Sm III have been measured for the first time using a time-resolved laser-induced fluorescence technique. Experimental data have been compared with semi-empirical calculations. The agreement is excellent for 4 levels with (6)Fdegrees as a parent term. Larger discrepancies (53 and 37%) are observed for 2 levels with (6)Hdegrees and (6)Fdegrees, respectively, as a parent term and are explainable by strong mixing and cancellation effects occurring in the line strength calculations which are responsible of "instabilities" occurring in the lifetimes considered as a function of J value within the term. Branching ratios for the lines depopulating the levels of interest have been measured by Fourier transform spectroscopy. A first set of oscillator strengths has been deduced for this ion. [less ▲]

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See detailStripe patterns in self-stratification experiments
Lecocq, N.; Vandewalle, Nicolas ULiege

in Fractals-Complex Geometry Patterns and Scaling in Nature and Society (2003), 11(Suppl. S), 259-269

We report pattern formation of complex stripes with binary and ternary granular mixtures. Ternary mixtures lead to a particular ordering of the strates which was not accounted for in former explanations ... [more ▼]

We report pattern formation of complex stripes with binary and ternary granular mixtures. Ternary mixtures lead to a particular ordering of the strates which was not accounted for in former explanations. Bouncing grains are found to have an important effect on strate formation. A complementary mechanism for self-stratification of binary and ternary granular mixtures is proposed. This mechanism leads to a simple model. Eventually we report the observation of self-stratification for a binary mixture of grains of the same size but with different shapes. [less ▲]

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See detailDetermination of polyisoprene-block-poly(methyl methacrylate) domain sizes using 1H spin diffusion
Werkhoven, Thekla M; Mulder, Fokko M; Zune, Catherine et al

in Macromolecular Chemistry and Physics (2003), 204(1), 46-51

The microphase structure of polyisoprene-block-poly(methyl methacrylate) diblock copolymers was studied using solid-state NMR techniques. Wideline separation spectroscopy reveals a narrow interphase ... [more ▼]

The microphase structure of polyisoprene-block-poly(methyl methacrylate) diblock copolymers was studied using solid-state NMR techniques. Wideline separation spectroscopy reveals a narrow interphase between the two polymers. The domain sizes of a lamellar sample and a sample with hexagonally ordered cylinders were determined using 1H spin diffusion. The lamellar sample shows a domain size of 16 ± 2 nm for the minor polyisoprene phase and a long period of 33 ± 4 nm. The cylindrical structure has a long period of 38 ± 7 nm, the diameter of the PMMA cylinders is 21 ± 4 nm. These results are about 20% below the estimates obtained from theoretical calculations according to Helfand and Wasserman [less ▲]

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See detailThree-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril
Garcia-Saez, I.; Mercuri, Paola ULiege; Papamicael, C. et al

in Journal of Molecular Biology (2003), 325(4), 651-660

The beta-lactamases are involved in bacterial resistance to penicillin and related compounds. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are thus becoming of major ... [more ▼]

The beta-lactamases are involved in bacterial resistance to penicillin and related compounds. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are thus becoming of major clinical importance. The structures of the Zn-beta-lactamase from Fluoribacter gormanii (FEZ-1) in the native and in the complex form are reported here. FEZ-I is a monomeric enzyme, which possesses two zinc-binding sites. These structures are discussed in comparison with those of the tetrameric L1 enzyme produced by Stenotrophomonas maltophilia. From this analysis, amino acids involved in the oligomerization of L1 are clearly identified. Despite the similarity in fold, the active site of FEZ-1 was found to be significantly different. Two residues, which were previously implicated in function, are not present in L1 or in FEZ-1. The broad-spectrum substrate profile of Zn-beta-lactamases arises from the rather wide active-site cleft, where various P-lactam compounds can be accommodated. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailProbing of the reaction progress at a PMMA/PS interface by using anthracene-labeled reactive PS chains
Yin, Zhihui; Koulic, Christian; Pagnoulle, Christophe et al

in Langmuir (2003), 19(2), 453-457

The progress of the interfacial reaction of polystyrene chains end-capped by a primary amine (PS-NH2) and PMMA chains end-capped by an anhydride (PMMA-anh) has been monitored by SEC-UV, by using ... [more ▼]

The progress of the interfacial reaction of polystyrene chains end-capped by a primary amine (PS-NH2) and PMMA chains end-capped by an anhydride (PMMA-anh) has been monitored by SEC-UV, by using anthracene-labeled polystyrene chains (anth-PS-NH2) as a probe. Assemblies of an anth-PS-NH2 layer and a PMMA-anh layer were annealed at 200 degreesC for various periods of time. The interfacial reaction rate depends on the molecular weight (MW) of the reactive precursors in relation to the gammaN value of the chains. For chains of low gammaN (chiN = 6), the reaction is faster because the interface becomes more diffuse with time, as observed by TEM and AFM, consistent with compatibilization of the weakly immiscible polymers by the copolymer formed in-situ. For chains of higher molecular weight and chiN (10, instead of 6), the interface is much sharper and the residence time at the interface of the symmetric diblock copolymer of higher molecular weight is also increased, which dramatically restricts the progress of the interfacial reaction under the annealing conditions used in this work. [less ▲]

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See detailDetermination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample
Dehouck, Pieter; Vander Heyden, Yvan; Smeyers-Verbeke, Johanna et al

in Analytica Chimica Acta (2003), 481

The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of ... [more ▼]

The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of uncertainty have been proposed. They include: within-laboratory uncertainty, reproducibility uncertainty, bias-included uncertainty and absolute uncertainty. Here we consider the evaluation of the reproducibility uncertainty derived from the results obtained in an inter-laboratory experiment. Nine laboratories participated in an inter-laboratory study for the analysis of phenoxymethylpenicillin. The analyses consisted of a Karl–Fischer water determination, an acid–base titration to assay phenoxymethylpenicillin and a liquid chromatography (LC) method to determine 4-hydroxyphenoxymethylpenicillin and other impurities. The experimental set-up allowed to obtain for each determination s2 r and s2L as estimates of the repeatability variance (σ2r ) and the between-laboratory variance (σ2L), respectively. The reproducibility uncertainties for the different assays were then derived from these estimates. [less ▲]

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See detailStabilization of a cocontinuous phase morphology by a tapered diblock or triblock copolymer in polystyrene-rich low-density polvethylene/polstyrene blends
Harrats, Charef; Fayt, Roger; Jérôme, Robert ULiege et al

in Journal of Polymer Science. Part B, Polymer Physics (2003), 41(2), 202-216

The stability against the thermal annealing of a cocontinuous two-phase morphology developed in polystyrene (PS)/low-density polyethylene (LDPE) blends containing 80 wt % PS was investigated. Blends ... [more ▼]

The stability against the thermal annealing of a cocontinuous two-phase morphology developed in polystyrene (PS)/low-density polyethylene (LDPE) blends containing 80 wt % PS was investigated. Blends containing 1, 5, and 10 wt % of a tapered diblock poly(styrene-block-hydrogenated butadiene) (P(S-b-hB)) or triblock poly(styrene-block-hydrogenated butadiene-block-styrene) (P(S-hB-S)) copolymer were melt-blended with roll-mill mixing equipment. The efficiency of each of the two copolymers in stabilizing against coalescence the cocontinuous morphology was examined. The tensile properties of the resulting blends, annealed and nonannealed, were also examined in relation to the morphology induced by thermal annealing. The phase morphology was studied by optical and scanning electron microscopy. With computer-aided image analysis, it was possible to obtain a measurable characteristic parameter to quantify the cocontinuous phase morphology. When it was necessary, the extraction of one phase with a selective solvent was performed. Although the observed differences were subtle, the tapered diblock exhibited a more efficient compatibilizing activity than the triblock copolymer, particularly at a low concentration of about 2 wt %. The superiority of the tapered diblock over the triblock might be due to its ability to quantitatively locate at the LDPE/PS interface and consequently form a more efficient barrier against the subsequent breakup of the elongated structures of the cocontinuous phase morphology. The tensile properties of the triblock-modified blends were more sensitive to thermal annealing than the tapered-modified ones. This deficiency was ascribed to the phase morphology coarsening of the dispersed polyethylene phase. [less ▲]

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See detailProperties of molten Ge chalcogenides: an ab initio molecular dynamics study
Raty, Jean-Yves ULiege; Gaspard, Jean-Pierre ULiege; Bichara, C.

in Journal of Physics : Condensed Matter (2003), 15(1 Sp. Iss. SI), 167-173

In this study, we perform first-principles molecular dynamics simulations of the eutectic alloy Ge15Te85 at five different densities and temperatures. We obtain structures in agreement with the available ... [more ▼]

In this study, we perform first-principles molecular dynamics simulations of the eutectic alloy Ge15Te85 at five different densities and temperatures. We obtain structures in agreement with the available diffraction data and obtain a new view of the molten Ge chalcogenides. We show that the anomalous volume contraction observed in the liquid 30 K above the eutectic temperature corresponds to a significant change of the Ge-Te partial structure factor. The detailed structural analysis shows that volume variations observed upon melting in Ge15Te85, as in liquid, GeSe and GeTe, can be explained in terms of the competition between two types of local environment of the germanium atoms. A symmetrical coordination octahedron is entropically favoured at high temperature, while an asymmetrical octahedron resulting from the local manifestation of the Peierls distortion is electronically favoured at lower temperatures. [less ▲]

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See detailAlong or across front survey strategy? An operational example at an unstable front
Rixen, Michel; Allen, J. T.; Alderson, S. et al

in Geophysical Research Letters (2003), 30(1),

[1] We present results of the optimization of near-real time on-board sampling strategy in the Iceland-Faroes oceanic frontal area, based on the outputs of a mesoscale 3D operational data assimilation ... [more ▼]

[1] We present results of the optimization of near-real time on-board sampling strategy in the Iceland-Faroes oceanic frontal area, based on the outputs of a mesoscale 3D operational data assimilation forecasting experiment. By minimizing a root mean square error cost function, we show that in this example an along-front sampling strategy, i.e. with transects parallel to the front, produces smaller errors in temperature, salinity, nitrate, phytoplankton, and zooplankton fields, as a result of a combination of the direction of the sampling of the front and errors associated with the asynopticy of observations (Doppler effect). This is contrary to the classic across-front sampling strategies that are used in most field experiments reported in the literature, i.e. where transects are perpendicular to the front. A control model shows that at these spatio-temporal scales, the along front sampling strategy is optimal when the frontal instability has sufficiently developed. [less ▲]

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See detailSex differences in the distribution of the steroid receptor coactivator SRC-1 in the song control nuclei of male and female canaries
Charlier, Thierry ULiege; Balthazart, Jacques ULiege; Ball, Gregory F

in Brain Research (2003), 959(2), 263-274

The steroid receptor coactivator SRC-1 modulates ligand-dependent transactivation of several nuclear receptors, including the receptors for sex steroid hormones. The distribution of SRC-1 transcripts was ... [more ▼]

The steroid receptor coactivator SRC-1 modulates ligand-dependent transactivation of several nuclear receptors, including the receptors for sex steroid hormones. The distribution of SRC-1 transcripts was analyzed here by in situ hybridization in coronal sections through the brain of male and female canaries. A broad but heterogeneous distribution of SRC-1 transcripts was observed with high numbers of densely labeled cells being present in many steroid-sensitive areas including the medial preoptic nucleus, several hypothalamic nuclei, five song control nuclei (HVc, the lateral and medial portion of the magnocellular nucleus of the anterior neostriatum, area X and the nucleus uvaeformis) and several catecholaminergic areas (area ventralis of Tsai, substantia nigra, locus coeruleus). The volume of two song control nuclei, HVc and area X were reconstructed based on the boundaries of the cell groups exhibiting a denser SRC-1 expression as compared to the surrounding areas. Sex differences in the expression of SRC-1 were also detected in several song control nuclei. In particular, the volume of HVc based on the high density of SRC-1 expression was significantly larger in males than in females. The effect of steroids on the song control system could be, at least in part, indirect and result from a modulation by steroids of the catecholaminergic inputs to the song control nuclei. The presence of the steroid receptor coactivator SRC-1 in the telencephalic song control nuclei and in the catecholaminergic cell groups that innervate the song system supports the idea that SRC-1 expression could play an active role in the control of singing behavior by modulating estrogen and androgen receptor action at both locations. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailDe novo backbone and sequence design of an idealized alpha/beta-barrel protein: Evidence of stable tertiary structure
Offredi, Fabrice; Dubail, Fabien; Kischel, Philippe ULiege et al

in Journal of Molecular Biology (2003), 325(1), 163-174

We have designed, synthesized, and characterized a 216 amino acid residue sequence encoding a putative idealized alpha/beta-barrel protein. The design was elaborated in two steps. First, the idealized ... [more ▼]

We have designed, synthesized, and characterized a 216 amino acid residue sequence encoding a putative idealized alpha/beta-barrel protein. The design was elaborated in two steps. First, the idealized backbone was defined with geometric parameters representing our target fold: a central eight parallel-stranded beta-sheet surrounded by eight parallel alpha-helices, connected together with short structural turns on both sides of the barrel. An automated sequence selection algorithm, based on the dead-end elimination theorem, was used to find the optimal amino acid sequence fitting the target structure. A synthetic gene coding for the designed sequence was constructed and the recombinant artificial protein was expressed in bacteria, purified and characterized. Far-UV CD spectra with prominent bands at 222nm and 208nm revealed the presence of alpha-helix secondary structures (50%) in fairly good agreement with the model. A pronounced absorption band in the near-UV CD region, arising from immobilized aromatic side-chains, showed that the artificial protein is folded in solution. Chemical unfolding monitored by tryptophan fluorescence revealed a conformational stability (DeltaG(H2O)) of 35kJ/mol. Thermal unfolding monitored by near-UV CD revealed a cooperative transition with an apparent T(m) of 65 degrees C. Moreover, the artificial protein did not exhibit any affinity for the hydrophobic fluorescent probe 1-anilinonaphthalene-8-sulfonic acid (ANS), providing additional evidence that the artificial barrel is not in the molten globule state, contrary to previously designed artificial alpha/beta-barrels. Finally, 1H NMR spectra of the folded and unfolded proteins provided evidence for specific interactions in the folded protein. Taken together, the results indicate that the de novo designed alpha/beta-barrel protein adopts a stable three-dimensional structure in solution. These encouraging results show that de novo design of an idealized protein structure of more than 200 amino acid residues is now possible, from construction of a particular backbone conformation to determination of an amino acid sequence with an automated sequence selection algorithm. [less ▲]

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See detailDifferential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories
Vörös, Gabor; Maquoi, Erik ULiege; Collen, Désiré et al

in Biochimica et Biophysica Acta-Gene Structure and Expression (2003), 1625(1), 36-42

ur objective was to investigate expression of A disintegrin and metalloproteinase (ADAM) and ADAM proteins with a thrombospondin (TS) motif (ADAMTS) family members in adipose tissue of lean and obese mice ... [more ▼]

ur objective was to investigate expression of A disintegrin and metalloproteinase (ADAM) and ADAM proteins with a thrombospondin (TS) motif (ADAMTS) family members in adipose tissue of lean and obese mice. Five-week-old male mice were kept on standard chow (SFD) or on high fat diet (HFD) for 15 weeks, and subcutaneous (SC) and gonadal (GON) adipose tissue, as well as mature adipocytes and stromal–vascular (S–V) cells were harvested. mRNA levels of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-α (TNF-α), ADAM-17 (TACE or TNF-α converting enzyme), ADAMTS-1 and ADAMTS-8 were quantified in isolated adipose tissues and cell fractions, and during differentiation of murine preadipocytes. The HFD resulted in a significantly enhanced weight of isolated SC and GON fat pads, and in enhanced blood levels of glucose, cholesterol and PAI-1. ADAM-17, TNF-α, PAI-1, ADAMTS-1 and ADAMTS-8 mRNA were detected in both SC and GON adipose tissue of lean mice (SFD). In SC adipose tissue of obese mice (HFD), the expression of ADAM-17 and PAI-1 was enhanced and that of ADAMTS-1 reduced, whereas in GON adipose tissue expression of TNF-α was enhanced and that of ADAMTS-8 reduced. In lean and obese mice, expression of ADAM-17, ADAMTS-1 and ADAMTS-8 was higher in the S–V cell fraction than in mature adipocytes. During differentiation of murine 3T3-F442A preadipocytes, expression of ADAM-17 and ADAMTS-1 remained virtually unaltered, whereas that of ADAMTS-8 decreased as adipocytes matured. Several ADAM and ADAMTS family members are expressed in adipose tissue and during differentiation of preadipocytes. Modulation of their expression upon development of obesity is adipose tissue-dependent. [less ▲]

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See detailLong-term optical spectrophotometric monitoring of comet C/1995 O1 (Hale-Bopp)
Rauer, H.; Helbert, J.; Arpigny, Claude ULiege et al

in Astronomy and Astrophysics (2003), 397

We observed comet C/1995 O1 (Hale-Bopp) at 4.6-2.9 AU pre-perihelion and 2.8-12.8 AU post-perihelion with optical long-slit spectroscopy. Emission bands of CN, C[SUB]3[/SUB], C[SUB]2[/SUB] and NH[SUB]2 ... [more ▼]

We observed comet C/1995 O1 (Hale-Bopp) at 4.6-2.9 AU pre-perihelion and 2.8-12.8 AU post-perihelion with optical long-slit spectroscopy. Emission bands of CN, C[SUB]3[/SUB], C[SUB]2[/SUB] and NH[SUB]2[/SUB] have been covered. Emission of C[SUB]3[/SUB] was detected up to 7.0 AU, and CN could be followed up to 9.8 AU post-perihelion. Spatial column density profiles of the radicals have been used to derive effective parent Haser scale lengths for heliocentric distances beyond 3 AU. Production rates were derived based on these Haser scale lengths. The observations of CN are in agreement with HCN as the major parent molecule of this radical at large distances from the Sun (i.e. beyond ~ 3 AU). We compare the measured CN production rate to sublimation rates of HCN from a simple nucleus sublimation model. The variation of CN production rates with changing heliocentric distance gives no indication for sublimation from the interior and is consistent with very little thermal lag of the nucleus. Based on observations collected at the European Southern Observatory, Chile, and the Observatoire de Haute Provence, France. [less ▲]

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See detailNutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1
Lijnen, Roger; Maquoi, Erik ULiege; Morange, Pierre et al

in Arteriosclerosis, Thrombosis, and Vascular Biology (2003), 23(1), 78-84

OBJECTIVE: The objective of this study was to investigate the role of plasminogen activator inhibitor-1 (PAI-1) in adipose tissue development in vivo. METHODS AND RESULTS: Transgenic (Tg) mice ... [more ▼]

OBJECTIVE: The objective of this study was to investigate the role of plasminogen activator inhibitor-1 (PAI-1) in adipose tissue development in vivo. METHODS AND RESULTS: Transgenic (Tg) mice overexpressing murine PAI-1 under control of the adipocyte promoter aP2 and wild-type (WT) controls were kept on standard food (SFD) or on high-fat diet (HFD) for 15 weeks. The body weight and the weight of the isolated subcutaneous and gonadal fat deposits of the Tg mice kept on the HFD were significantly lower than those of the WT mice. The number of adipocytes in the adipose tissue was similar for Tg and WT mice on the HFD, but adipocyte hypotrophy and a significantly lower ratio of stroma cells/adipocytes were observed in the Tg mice. A significant negative correlation (P<0.01) was observed between expression of preadipocyte factor-1, which blocks adipocyte differentiation, and adipose tissue weight. Fasting insulin and total cholesterol levels on the HFD were lower in Tg than in WT mice. CONCLUSIONS: High circulating PAI-1 levels attenuate nutritionally induced obesity. This may be related to modifications in adipose tissue cellularity affecting weight and plasma metabolic parameters. [less ▲]

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See detailClose pairs of quasars with different redshifts: New observations and results
Sluse, Dominique ULiege; Surdej, Jean ULiege; Claeskens, Jean-François ULiege et al

in Astronomy and Astrophysics (2003), 397

Burbidge et al. (\cite {burbidge}) argue that the observed number of quasar pairs with small angular separations and different redshifts (typically Delta theta <= 5 arcsec and Delta z > 0.1 ) is not ... [more ▼]

Burbidge et al. (\cite {burbidge}) argue that the observed number of quasar pairs with small angular separations and different redshifts (typically Delta theta <= 5 arcsec and Delta z > 0.1 ) is not compatible with a random distribution of quasars over the sky. After a brief review of all known quasar pairs with different redshifts, we show by means of very simple calculations that the probability of finding the three accepted pairs accidentally is of the order of 10%. We conclude that, under realistic hypotheses, the observed number of quasar pairs with different redshifts is not unlikely. We also present arguments showing that gravitational lensing biases are probably not strong enough to significantly increase the expected number of quasar pairs. The failure to detect with HST a secondary lensed image of the background quasar near the foreground one in these three pairs supports this view. [less ▲]

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See detailCost Action F3 'Structural Dynamics' (1997-2001) - An European Co-operation in the Field of Science and Technology
Golinval, Jean-Claude ULiege; Link, M.

in Mechanical Systems & Signal Processing (2003), 17(1), 3-7

This section is concerned with presenting the objective, the scientific programme and the organisation of COST Action F3 in Structural Dynamics. (C) 2003 Elsevier Science Ltd. All rights reserved.

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See detailSafe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine
Kaskas, B. A.; Louis, Edouard ULiege; Hindorf, U. et al

in Gut (2003), 52(1), 140-142

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6 ... [more ▼]

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recommended that these patients should not receive AZA or 6-MP treatment for inflammatory bowel disease. We report for the first time that Crohn's disease patients with TPMT deficiency can be successfully treated with AZA. We illustrate this with three cases where treatment has been successful and toxicity has been avoided by carefully titrating the drug dose. Thus very low TPMT activity demands pharmacogenetically guided dosing. [less ▲]

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See detailECL benchmark: Application of the proper orthogonal decomposition
Lenaerts, Vincent; Kerschen, Gaëtan ULiege; Golinval, Jean-Claude ULiege

in Mechanical Systems & Signal Processing (2003), 17(1), 237-242

The aim of this paper is to apply the proper orthogonal decomposition method to a non-linear system consisting of an experimental cantilever beam with a geometrical non-linearity. (C) 2003 Elsevier ... [more ▼]

The aim of this paper is to apply the proper orthogonal decomposition method to a non-linear system consisting of an experimental cantilever beam with a geometrical non-linearity. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailMutuelle communautaire de croissance (MC²) et développement rural à Baham (Cameroun)
Lekane Tsobgou, Dieudonné ULiege

in Cahiers d'Outre-Mer (Les) (2003), 221(janvier-Maars), 67-86

A micro-bank for rural development in Baham (Cameroon). The creation of microfinancing institutions for rural activities has enabled rural development to take off in poor countries. In Baham, amicro-bank ... [more ▼]

A micro-bank for rural development in Baham (Cameroon). The creation of microfinancing institutions for rural activities has enabled rural development to take off in poor countries. In Baham, amicro-bank was created with the technical and financial support of such partners as the ADAF and the afriland first-Bank. It aims at combining modern techniques of management and sociocultural values, in order to make as many members as possible benefit by its services. This study focuses on the nature and the functioning of the bank, its means of action and financing, its role in the agro-pastoral development and the socio-economical evolution of the district and of the village. [less ▲]

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See detailHRM practices in a process of organisational change: A contextualist perspective
Pichault, François ULiege; Schoenaers, Frédéric ULiege

in Applied Psychology : An International Review = Psychologie Appliquée : Revue Internationale (2003), 52(1), 120-143

This paper explores the interactions between HRM practices and contextual factors in a process of organisational change. We first present a typology of HRM models, in line with Mintzberg's organisational ... [more ▼]

This paper explores the interactions between HRM practices and contextual factors in a process of organisational change. We first present a typology of HRM models, in line with Mintzberg's organisational configurations. We then develop a contingent view on HRM issues-highlighting the influence of some contextual factors-followed by a more political view which reveals the power games between the different stakeholders, each of them enacting specific contextual factors. Finally, we give a more concrete understanding of the contextualist framework discussing its application to a case study in the alimentary sector. [less ▲]

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See detailEffects of Alzheimer's disease on the recognition of novel versus familiar words : Neuropsychological and clinico-metabolic data
Lekeu, Françoise ULiege; Van der Linden, Martial ULiege; Degueldre, Christian ULiege et al

in Neuropsychology (2003), 17(1), 143-154

This study explored recognition memory performance for novel versus familiar words in Alzheimer's disease (AD) patients and normal controls (NCs), using an adaptation of E. Tulving and N. Kroll's (1995 ... [more ▼]

This study explored recognition memory performance for novel versus familiar words in Alzheimer's disease (AD) patients and normal controls (NCs), using an adaptation of E. Tulving and N. Kroll's (1995) procedure. Results showed that both groups exhibited more hits and more false alarms for familiar than for novel words. The groups did not differ in the recognition of familiar words, reflecting preserved familiarity processes in AD. However, AD patients made more false alarms than NCs in the recognition of novel words, reflecting impairment of recollection processes in AD. A positron emission tomography analysis of clinico-metabolic correlations in AD patients showed a correlation between recognition of novel words and right hippocampal activity, whereas recognition of familiar words was more related to metabolic activity in the left posterior orbitofrontal cortex. [less ▲]

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See detailLaparoscopic liver resection of benign liver tumors - Results of a multicenter European experience
Descottes, B.; Glineur, D.; Lachachi, François et al

in Surgical Endoscopy and Other Interventional Techniques (2003), 17(1), 23-30

Objective: The objective of this study was to assess the feasibility, safety, and outcome of laparoscopic liver resection for benign liver tumors in a multicenter setting. Background: Despite restrictive ... [more ▼]

Objective: The objective of this study was to assess the feasibility, safety, and outcome of laparoscopic liver resection for benign liver tumors in a multicenter setting. Background: Despite restrictive, tailored indications for resection in benign liver tumors, an increasing number of articles have been published concerning laparoscopic liver resection of these tumors. Methods: A retrospective study was performed in 18 surgical centres in Europe regarding their experience with laparoscopic resection of benign liver tumors. Detailed standardized questionnaires were used that focused on patient's characteristics, clinical data, type and characteristics of the tumor, technical details of the operation, and early and late clinical outcome. Results: From March 1992 to September 2000, 87 patients suffering from benign liver tumor were included in this study: 48 patients with focal nodular hyperplasia (55%), 17 patients with liver cell adenoma (21%), 13 patients with hemangioma (15%), 3 patients with hamartoma (3%), 3 patients with hydatid liver cysts (3%), 2 patients with adult polycystic liver disease (APLD) (2%), and 1 patient with liver cystadenoma (1%). The mean size of the tumor was 6 cm, and 95% of the tumors were located in the left liver lobe or in the anterior segments of the right liver. Liver procedures included 38 wedge resections, 25 segmentectomies, 21 bisegmentectomies (including 20 left lateral segmentectomies), and 3 major hepatectomies. There were 9 conversions to an open approach (10%) due to bleeding in 45% of the patients. Five patients (6%) received autologous blood transfusion. There was no postoperative mortality, and the postoperative complication rate was low (5%). The mean postoperative hospital stay was 5 days (range, 2-13 days). At a mean follow-up of 13 months (median, 10 months; range, 2-58 months), all patients are alive without disease recurrence, except for the 2 patients with APLD. Conclusions: Laparoscopic resection of benign liver tumors is feasible and safe for selected patients with small tumors located in the left lateral segments or in the anterior segments of the right liver. Despite the use of a laparoscopic approach, selective indications for resection of benign liver tumors should remain unchanged. When performed by expert liver and laparoscopic surgeons in selected patients and tumors, laparoscopic resection of benign liver tumor is a promising technique. [less ▲]

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See detailLa détention et l'expulsion collective des étrangers. Commentaire de l'affaire Conka
Carlier, Jean-Yves ULiege

in Revue Trimestrielle des Droits de l'Homme (2003), 14(53), 198-222

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See detailAnatomical relationships between aromatase-immunoreactive neurons and nitric oxide synthase as evidenced by NOS immunohistochemistry or NADPH diaphorase histochemistry in the quail forebrain
Balthazart, Jacques ULiege; Panzica, G. C.; Krohmer, R. W.

in Journal of Chemical Neuroanatomy (2003), 25(1), 39-51

In Japanese quail (Coturnix japonica), previous studies indicated that the distribution of reduced nicotinamide dinucleotide phosphate (NADPH) diaphorase overlaps with steroid-sensitive areas that contain ... [more ▼]

In Japanese quail (Coturnix japonica), previous studies indicated that the distribution of reduced nicotinamide dinucleotide phosphate (NADPH) diaphorase overlaps with steroid-sensitive areas that contain dense populations of aromatase-immunoreactive (ARO-ir) cells. We investigated here the anatomical relationships between aromatase (ARO) and nitric oxide synthase (NOS)containing cells that were visualized both by NOS-immunohistochemistry and NADPH-histochemistry. The distribution of ARO-ir and of NADPH-positive cells in the forebrain observed here matched exactly the distribution previously reported. The distribution of NOS-immunoreactive material in the vicinity of ARO-ir cell groups appeared similar to the distribution of NADPH-positive structures previously identified by histochemistry. The number of NOS-immunoreactive cells was similar to the number of NADPH-positive cells and them were found in the same brain regions. In contrast. few NOS-immunoreactive fibers were observed whereas numerous NADPH-positive fibers and Punctuate structures were present in many areas. Major groups of NOS-immunoreactive/ NADPH-positive neurons were adjacent to the main ARO-ir cell groups, such as the medial preoptic nucleus. the bed nucleus of the stria terminalis and the nucleus ventromedialis hypothalamic. Hove ever. examination of adjacent sections indicated that there is very little overlap between the NOS-immunoreactive and ARO-ir cell populations. This notion got further support by double-labeled sections where no double-labeled cells could be identified. In sections stained simultaneously by histochemistry for NADPH and immunohistochemistry for ARO, many NADPH-positive fibers and punctate structures were closely associated with ARO-ir perikarya. Taken together, the present data indicate that NOS is not or very rarely colocalized with ARO but that NOS inputs are closely associated with ARO-ir cells. Based on previous work in a variety of model systems. it can be hypothesized that these inputs modulate the expression or activity of ARO in the quail brain. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailNew nanocomposite materials based on plasticized poly(L-lactide) and organo-modified montmorillonites: thermal and morphological study
Paul, Marie-Amélie; Degée, Philippe; Henrist, Catherine ULiege et al

in Polymer (2003), 44(2), 443-450

Plasticized poly(L-lactide) (PLA) based nanocomposites were prepared by melt blending of the matrix with 20 wt% of poly(ethyleneglycol) 1000 (PEG 1000) and different amounts of montmorillonite, organo ... [more ▼]

Plasticized poly(L-lactide) (PLA) based nanocomposites were prepared by melt blending of the matrix with 20 wt% of poly(ethyleneglycol) 1000 (PEG 1000) and different amounts of montmorillonite, organo-modified or not. The intercalation of the polymer chains between the aluminosilicates layers and morphological structure of the filled PLAs were analysed by wide-angle X-ray scattering (WAXS). Thermogravimetric analyses (TGA) and differential scanning calorimetry (DSC) were performed to study the thermal behaviour of the prepared composites. At constant filler level, it appears that from all the clays studied, the montmorillonite organo-modified by bis-(2-hydroxyethyl)methyl (hydrogenated tallowalkyl) ammonium cations brings the greater effect in terms of thermal stability. Increasing the amount of clay allows to delay the onset of thermal degradation of the plasticized polymer matrix. It was also pointed out, by WAXS and DSC analyses, that it exists a real competition between PEG 1000 and PLA for the intercalation into the interlayer spacing of the clay. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailCoût d'oeil
Gauthier, Jean-Marie ULiege

in Cahiers de Psychologie Clinique (2003)

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See detailLes anevrysmes ventriculaires: principes de leur traitement chirurgical
Radermecker, M.A.; Moscato, A.; Coimbra, C. et al

in Revue Médicale de Liège (2003), 58(1), 33-6

After reviewing the historical background, the morphology and physiopathology of left ventricular aneurysms, the authors review the physiology, the technical aspects, and the current surgical indications ... [more ▼]

After reviewing the historical background, the morphology and physiopathology of left ventricular aneurysms, the authors review the physiology, the technical aspects, and the current surgical indications of aneurysmectomy, with a particular emphasis on the concept of endoventriculoplasty of Jatene [less ▲]

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See detailPregnancy in rabbits actively immunized against bovine pregnancy-associated glycoprotein 1
Banga-Mboko, Henri; Halloy, D.; Perenyi, Zsolt et al

in Fertility and Sterility (2003), 79(1), 226-227

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See detailRandom mutagenesis of PDZOmi domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis
Junqueira, Daniela; Cilenti, Lucia; Musumeci, Lucia ULiege et al

in Oncogene (2003), 22

Omi is a mammalian serine protease that is localised in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting ... [more ▼]

Omi is a mammalian serine protease that is localised in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the Xchromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies on its proteolytic activity. Omi is synthesized as a precursor polypeptide and is processed to an active serene protease with a unique PDZ domain. PDZ domains recognise the extreme carboxyl terminus of target proteins. Internal peptides that are able to fold into a b-finger are also reported to bind some PDZ domains. Using a modified yeast two-hybrid system, PDZOmi mutants were isolated by their ability to bind the carboxyl terminus of human Myc oncoprotein in yeast as well as in mammalian cells. One such PDZm domain (PDZ-M1), when transfected into mammalian cells, was able to bind to endogenous Myc protein and induce cell death. PDZ-M1-induced apoptosis was entirely dependent on the presence of Myc protein and was not observed when c-myc null fibroblasts were used. Our studies indicate that the PDZ domain of Omi can provide a prototype that could easily be exploited to target specifically and inactivate oncogenes by binding to their unique carboxyl terminus. [less ▲]

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See detailEuropean Organization for Research and Treatment of Cancer (EORTC) 08957 phase II study of topotecan in combination with cisplatin as second-line treatment of refractory and sensitive small cell lung cancer
Ardizzoni, A.; Manegold, C.; Debruyne, C. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2003), 9(1), 143-150

Purpose: The purpose of this study was to assess the activity and toxicity of a combined regimen of topotecan and cisplatin in "sensitive" (s) and "refractory" (r) small-cell lung cancer (SCLC) patients ... [more ▼]

Purpose: The purpose of this study was to assess the activity and toxicity of a combined regimen of topotecan and cisplatin in "sensitive" (s) and "refractory" (r) small-cell lung cancer (SCLC) patients treated previously. Experimental Design: Patients with measurable SCLC and progressive disease after one first-line regimen were eligible for the study. Patients were enrolled in two separate groups: r group (patients who failed first-line treatment <3 months from treatment discontinuation) and s group (patients who responded to first-line treatment and progressed 2:3 months after treatment discontinuation). Cisplatin was given i.v. at the dose of 60 mg/m(2) on day 1, and topotecan was administered as a daily i.v. infusion at the dose of 0.75 mg/m(2) from day 1 to 5, every 3 weeks. Results: A total of 110 eligible (68 s and 42 r) patients were enrolled from 24 institutions. The main patient characteristics were as follows: median age 60 (s) and 55 (r) years, median performance status 1 for both (s) and (r). Seventy-four percent (s) and 67% (r) had extensive stage disease, including 22% and 36%, respectively, with brain metastases. A total of 398 chemotherapy courses were administered [median 4 (s) and 3 (r) per patient]. The most frequent and serious toxicity was myelosuppression. Grade IV neutropenia occurred in 62% (s) and 49% (r) of patients, with a 19% (s) and 15% (r) incidence of febrile neutropenia, and grade IV thrombocytopenia in 54% (s) and 44% (r). Most of these toxicities occurred during the first chemotherapy course and led to topotecan dose reduction and/or delay in the following courses. Grade III-IV nonhematological toxicity was uncommon. Five deaths possibly related to toxicity occurred among s patients only. Objective responses have been documented in 20 s patients, 19 partial responses and 1 complete response, (29.4% response rate; 95% confidence interval, 19-42), whereas, among r patients, 10 partial responses have been observed (23.8% response rate; 95% confidence interval, 12-39). Median survival for s and r was 6.4 and 6.1 months, respectively. Conclusions: The combination of cisplatin and topotecan, at this dose and schedule, shows activity and promising results in patients with refractory SCLC, with reversible myelosuppression being the main side effect. Additional development of this regimen, using better-tolerated schedules, is warranted in patients with refractory SCLC. [less ▲]

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function
Dogné, Jean-Michel ULiege; de Leval, X.; Kolh, Philippe ULiege et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003), 68(1), 49-54

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and ... [more ▼]

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and thromboxane synthase of human platelets. The drug affinity for TP receptors of human washed platelets has been determined. In this test BM-567 showed a high affinity (IC50: 1.1+/-0.1 nM) for the TP receptors in comparison with BM-531 (IC50: 7.8+/-0.7 nM) and sulotroban (IC50: 931+/-85 nM), two TXA(2) antagonists. We also demonstrated that BM-567 prevented platelet aggregation induced by arachidonic acid (AA) (600 muM) (ED100: 0.20+/-0.10muM), U-46619, a stable TXA(2) agonist (1 muM) (ED50: 0.30+/-0.04 muM) and collagen (1 mug ml(-1)) (% of inhibition: 44.3+/-4.3% at 10 muM) and inhibited the second wave of ADP (2 muM). Moreover, when BM-567 was incubated in whole blood from healthy donors, the closure time measured by the Platelet Function analyzer (PFA-100) was significantly prolonged (closure time: 215+/-21 s) by using collagen/epinephrine cartridges. Finally, at the concentration of 1 muM, BM-567 completely reduced the TXB2 production from human platelets stimulated with AA (600 muM). These results indicate that BM-567 is a novel combined TXA(2) receptor antagonist and thromboxane synthase inhibitor characterized by a powerful antiplatelet potency. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailEarly reactions of light-induced protochlorophyllide and chlorophyllide transformations analyzed in vivo at room temperature with a diode array spectrofluorometer
Boddi, B.; Popovic, R.; Franck, Fabrice ULiege

in Journal of Photochemistry and Photobiology B : Biology (2003), 69(1), 31-39

The steps of protochlorophyllide (Pchlide) photoreduction and subsequent chlorophyllide (Chlide) transformations which occur in the seconds to minutes time-scale were studied using a diode array ... [more ▼]

The steps of protochlorophyllide (Pchlide) photoreduction and subsequent chlorophyllide (Chlide) transformations which occur in the seconds to minutes time-scale were studied using a diode array spectrofluorometer in dark-grown barley leaves. The intensity of the excitation light was varied between 3 and 2500 mumol m(-2) s(-1) and a series of fluorescence spectra were recorded at room temperature in the seconds and minutes time scales. In certain experiments, 77-K emission spectra were measured with the same equipment. The high quality of the spectra allowed us to run spectral resolution studies which proved the occurrence, at room temperature, of multiple Pchlide and Chlide forms found previously in 77-K spectra. The comparison of the 77-K and room-temperature spectra showed that the fluorescence yields of the nonphotoactive 633-nm Pchlide form and of the Chlide product emitting at 678 nm were temperature independent. The fluorescence intensity of aggregated NADPH-pigment-POR complexes (photoactive 656-nm Pchlide and 693-nm Chlide forms) were strongly increased at 77 K, while that of the NADP(+)-Chlide-POR (684-686-nm Chlide form) was much less affected by temperature. Information was obtained also about the dynamics of the transformation of pigment forms in the light at different photon densities. At low light intensities, the phototransformation of the 642-644-nm Pchlide form was faster than that of the 654-656-nm form. The relative amplitudes of Gaussian components related to different Chlide forms found after exposure to a constant amount of photons strongly depended on the light intensity used. Strong quenching of all Chlide components occurred upon prolonged exposure to high intensity light. These effects are discussed by considering the interconversion processes between different forms of the pigment-protein complexes, their relative fluorescence yields and energy migration processes. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailCorrelation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate.
Bruyère, Olivier ULiege; Honore, Aline; Ethgen, Olivier ULiege et al

in Osteoarthritis and Cartilage (2003), 11(1), 1-5

OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year ... [more ▼]

OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year randomized, placebo-controlled, prospective study, of 212 patients with knee OA, recruited in an osteoarthritic outpatient clinic and having been part of a study evaluating the effect of glucosamine sulfate on symptom and structure modification in knee OA. MATERIAL AND METHODS: Measurements of mean joint space width (JSW), assessed by a computer-assisted method, were performed at baseline and after 3 years, on weightbearing anteroposterior knee radiographs. RESULTS: In the placebo group, baseline JSW was significantly and negatively correlated with the joint space narrowing observed after 3 years (r=-0.34, P=0.003). In the lowest quartile of baseline mean JSW (<4.5mm), the JSW increased after 3 years by (mean (S.D.)) 3.8% (23.8) in the placebo group and 6.2% (17.5) in the glucosamine sulfate group. The difference between the two groups in these patients with the most severe OA at baseline was not statistically significant (P=0.70). In the highest quartile of baseline mean JSW (>6.2mm), a joint space narrowing of 14.9% (17.9) occurred in the placebo group after 3 years while patients from the glucosamine sulfate group only experienced a narrowing of 6.0% (15.1). Patients with the most severe OA at baseline had a RR of 0.42 (0.17-1.01) to experience a 0.5mm joint space narrowing over 3 years, compared to those with the less affected joint. In patients with mild OA, i.e. in the highest quartile of baseline mean JSW, glucosamine sulfate use was associated with a trend (P=0.10) towards a significant reduction in joint space narrowing. CONCLUSION: These results suggest that patients with the less severe radiographic knee OA will experience, over 3 years, the most dramatic disease progression in terms of joint space narrowing. Such patients may be particularly responsive to structure-modifying drugs. [less ▲]

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See detailEffect of manipulation and irrelevant noise on working memory capacity of patients with Alzheimer's dementia
Belleville, Sylvie; Rouleau, Nancy; Van der Linden, Martial ULiege et al

in Neuropsychology (2003), 17(1), 69-81

The effect of manipulation and distracting noise on immediate serial recall was measured in patients with dementia of the Alzheimer type (DAT), neurologically healthy elderly individuals and young adults ... [more ▼]

The effect of manipulation and distracting noise on immediate serial recall was measured in patients with dementia of the Alzheimer type (DAT), neurologically healthy elderly individuals and young adults. In experiment 1, the authors compared serial word recall with word recall in alphabetical order. Alphabetical recall requires the active manipulation of the contents of working memory. Findings indicated that DAT patients were severely impaired in the alphabetical recall task, whereas the performance of neurologically healthy elderly participants was comparable with the performance of young adult participants. In experiment 2, the authors investigated the effect of different irrelevant auditory backgrounds on immediate digit recall. In this task, both elderly participants and DAT patients performed similarly to the group of young adult participants, indicating comparable efficacy to resist auditory distraction. [less ▲]

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See detailLes Guerres d'Emmanuel
Dejasse, Erwin ULiege

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (2003), 8

Two of Emmanuel Guibert's works have the Second World War as backdrop: "Brune", his first album, and "La Guerre d'Alan" which he started six yeras later. Erwin Dejasse does a comparative study that shows ... [more ▼]

Two of Emmanuel Guibert's works have the Second World War as backdrop: "Brune", his first album, and "La Guerre d'Alan" which he started six yeras later. Erwin Dejasse does a comparative study that shows how dissimilar they are and to what extent "La Guerre d'Alan" obtained succes in oposition to the earlier work. [less ▲]

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See detailDoes radiotherapy have consequences on plasma concentration of toxic pollutants?
Charlier, Corinne ULiege; Closon, Marie-Thérèse ULiege; Plomteux, Guy ULiege

in Bulletin of Environmental Contamination & Toxicology (2003), 70(1), 17-21

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See detailUse of a weighted random regression test-day model to better relate observed somatic cell score to mastitis infection likelihood
Gengler, Nicolas ULiege; Mayeres, P.

in Interbull Bulletin (2003), 31

Current methods to analyze somatic cell counts or scores do not differentiate the origins of observed values, they rely on the simple hypothesis that a "higher" value is linked to an intra-mammarian ... [more ▼]

Current methods to analyze somatic cell counts or scores do not differentiate the origins of observed values, they rely on the simple hypothesis that a "higher" value is linked to an intra-mammarian infection. This hypothesis may not be totally valid, but until now proposed alternatives were not usable in large scale genetic evaluations. A simple modification of currently used random regression test-day models is presented that weight observed somatic cell scores by a weight that expresses mastitis infection likelihood. Results showed that despite high correlation with breeding values obtained without the weight, differences that were observed were highly related to mastitis results in Nordic countries. Sire breeding values obtained with this method were also submitted to the March 2003 INTERBULL test-run. They showed the largest average correlations of all populations with mastitis results from Nordic populations. The proposed method is currently implemented and used in routine in the genetic evaluation for somatic cell score in the Walloon Region of Belgium. [less ▲]

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See detailVagus nerve stimulation in awake rats reduces formalin-induced nociceptive behaviour and fos-immunoreactivity in trigeminal nucleus caudalis
Bohotin, C.; Scholsem, M.; Multon, Sylvie ULiege et al

in Pain (2003), 101(1-2), 3-12

Besides its well-established efficacy in epilepsy, vagus nerve stimulation (VNS) may be of potential interest in pain treatment. It has, however, not yet been assessed in animal pain models with the ... [more ▼]

Besides its well-established efficacy in epilepsy, vagus nerve stimulation (VNS) may be of potential interest in pain treatment. It has, however, not yet been assessed in animal pain models with the devices and stimulation protocols used in humans. We have therefore studied in awake rats the effects of left cervical VNS on trigeminal nociception using an implantable electrode and stimulator (NCP-Cyberonics((R)). VNS was applied for 24 h at 2 mA intensity, 20 Hz frequency, 0.5 ms pulse width and a duty cycle of 20 s ON/18 s OFF. As a nociceptive stimulus, we injected formalin into the left mystacial vibrissae, assessed behaviour for 45 min and sacrificed the animals 45 min later. Fos-immunoreactive (Fos-Ir) neurons were counted in laminae I-II of trigeminal nucleus caudalis (TNC on both sides. We used three groups of control animals: VNS without formalin, formalin without VNS and sham VNS (implanted without stimulation or formalin). Whereas sham VNS had no significant effect, VNS alone increased Fos expression in ipsilateral TNC in addition to the expected increase in nucleus tractus solitarius. It also significantly attenuated the increase of Fos-Ir neurons observed in ipsilateral TNC laminae I-II after formalin injection. If the proper VNS effect on Fos-expression was subtracted, the reduction of formalin-induced nociceptor activation was 55%. VNS also reduced nociceptive behaviour on average by 96.1% during the early phase (0-6 min) and by 60.7% during the late phase (6-45 min) after the formalin injection. These results suggest that VNS applied with a device used in human therapy may have in awake rats a significant antinociceptive effect in a model of trigeminal pain. (C) 2002 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPhenomenal characteristics of cryptomnesia
Brédart, Serge ULiege; Lampinen, J. M.; Defeldre, A. C.

in Memory (2003), 11(1), 1-11

Qualitative characteristics of cryptomnesia, or unintentional plagiarism were investigated. In Experiment I we compared accurate and inaccurate source attributions in terms of their level of confidence ... [more ▼]

Qualitative characteristics of cryptomnesia, or unintentional plagiarism were investigated. In Experiment I we compared accurate and inaccurate source attributions in terms of their level of confidence using instructions that did not require a fixed number of responses. Confidence was lower for plagiarised responses than for correct responses. Nevertheless, participants provided high ratings of certainty for a large proportion of their plagiarised responses. In Experiment 2 the phenomenological differences between plagiarised recall and veridical recall were compared by using an adaptation of the memory characteristics questionnaire (Johnson, Foley, Suengas, [less ▲]

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See detailResults obtained by minimising natural frequency and mac-value errors of a beam model
Thonon, C.; Golinval, Jean-Claude ULiege

in Mechanical Systems & Signal Processing (2003), 17(1), 65-72

This paper reports the procedure followed by the 'LTAS-Vibrations et Identification des Structures' research group to generate a low-order finite element (FE) model of the GARTEUR SM-AG19 structure. The ... [more ▼]

This paper reports the procedure followed by the 'LTAS-Vibrations et Identification des Structures' research group to generate a low-order finite element (FE) model of the GARTEUR SM-AG19 structure. The model is made of beam elements, local inertia and rigid body elements. The philosophy of the updating method is first based on the correlation of the experimental data with the results of the FE model and on the localisation of errors in the model. Updating parameters are then selected using eigenvalue sensitivity and model error localisation analyses. After updating, the quality of the FE model is assessed in terms of accuracy of the response prediction to structural modifications. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailModal identification and damage detection using the data-driven stochastic subspace and ARMAV methods
Bodeux, Jean-Bernard; Golinval, Jean-Claude ULiege

in Mechanical Systems & Signal Processing (2003), 17(1), 83-89

This paper presents results of modal identification and damage detection on the Steel-Quake structure using the autoregressive moving average vector and data-driven stochastic subspace methods. The ... [more ▼]

This paper presents results of modal identification and damage detection on the Steel-Quake structure using the autoregressive moving average vector and data-driven stochastic subspace methods. The methods directly work with the recorded time signals and allow to analyse linear systems where only the system output is measured, while the input is unknown but produced by uncorrelated random signals. These techniques can also be used directly to analyse data obtained from the free response of linear systems. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailDescription of the STEELQUAKE benchmark
Molina, F. J.; Pascual, R.; Golinval, Jean-Claude ULiege

in Mechanical Systems & Signal Processing (2003), 17(1), 77-82

A large-size two-storey steel structure with reinforced-concrete slabs was used for a damage detection benchmark. The modal tests at the original and damaged states were performed by impact-hammer ... [more ▼]

A large-size two-storey steel structure with reinforced-concrete slabs was used for a damage detection benchmark. The modal tests at the original and damaged states were performed by impact-hammer excitation. The damage consisted of major cracks at some of the beam-to-column joints and was introduced by seismic testing up to large deformations by means of hydraulic jacks. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailThe stem cell mobilizing capacity of patients with acute myeloid leukemia in complete remission correlates with relapse risk: results of the EORTC-GIMEMA AML-10 trial
Keating, S.; Suciu, S.; de Witte, T. et al

in Leukemia (2003), 17(1), 60-67

Variable numbers of CD34(+) cells can be harvested from the blood of AML patients in CR after G-CSF supported mobilization following consolidation chemotherapy. We hypothesized that a decreased ability to ... [more ▼]

Variable numbers of CD34(+) cells can be harvested from the blood of AML patients in CR after G-CSF supported mobilization following consolidation chemotherapy. We hypothesized that a decreased ability to mobilize stem cells reflects a chemotherapy-induced reduction in the number of normal and leukemic stem cells. We therefore analyzed whether the mobilizing capacity of these patients was of prognostic significance. 342 AML-patients in first CR received daily G-CSF from day 20 of the consolidation course and underwent 1-6 aphereses to obtain a minimum dose of 2 x 10(6) CD34(+) cells/kg. Afterwards they were randomized for autologous bone marrow (M) or blood SCT. As a surrogate marker for the mobilizing capacity, the highest yield of CD34(+) cells of a single apheresis was adopted. Patients could be categorized into four groups: no harvest (n = 76), low yield (<1 x 10(6) CD34(+)/kg; n = 50), intermediate yield (1-6.9 x 10(6) CD34(+) cells/kg; n = 128) and high yield ( :7 x 106 CD34+ cells/kg; n = 88). The median follow-up was 3.4 years; 163 relapses and 16 deaths in CR were reported. Autologous blood or BM SCT was performed in 36%, 64%, 81% and 88%, respectively, of the patients assigned to the no harvest, low, intermediate and high CD34(+) yield group. The 3-year disease-free survival rate was 46.7%, 65.0%, 50.4% and 26.9% (P= 0.0002) and the relapse incidence was 47.5%, 30.1%, 43.1% and 71.9% (P < 0.0001). Multivariate Cox's proportional hazards model showed that the CD34(+) yield was the most important independent prognostic variable (P = 0.005) after cytogenetics. Patients with the highest mobilizing capacity have a poor prognosis due to an increased relapse incidence. [less ▲]

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See detailFire tests and calculation methods for circular concrete columns
Franssen, Jean-Marc ULiege; Dotreppe, Jean-Claude ULiege

in Fire Technology (2003), 39(1), 89-97

The introduction sets the scene of the present paper i.e. the extensive research works performed at the University of Liege in order to derive acceptable calculation methods for the re design of concrete ... [more ▼]

The introduction sets the scene of the present paper i.e. the extensive research works performed at the University of Liege in order to derive acceptable calculation methods for the re design of concrete columns. It is explained that all previous works have been based on square or rectangular cross sections, for which corner spalling was observed very often, whereas circular section are nowadays becoming more and more popular. In order to examine the influence of the circular shape on the behavior under re conditions, an experimental research study has been performed recently at the University of Liege. This paper describes the test procedure, the observations made, and the values obtained for the re resistance. Theoretical methods have been developed for a quick, safe, and efficient design of concrete columns under re conditions. These methods have been applied successfully to the recently tested circular columns. [less ▲]

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See detailDownregulation of putative tumor suppressor gene TSC-22 in human brain tumors.
Shostak, Kateryna ULiege; Dmitrenko, Vladimir V.; Garifulin, Oleg M. et al

in Journal of Surgical Oncology (2003), 82(1), 57-64

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and ... [more ▼]

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and human postnatal brain cDNA libraries was performed by differential hybridization with glioblastoma multiforme and human normal brain cDNAs. RESULTS: Repeated differential hybridization of more than 100 cDNA clones selected by primary screening and analysis of RNA from adult normal brain and glial tumors showed 16 nucleotide sequences differentially expressed between normal brain and brain tumors. Among others, decreased content in astrocytic tumors was determined for TSC-22 mRNA corresponding to cDNA in the ICRFp507J1041 clone from human fetal brain cDNA library. Northern blot hybridization of RNA from different human brain tumors showed very low amounts of TSC-22 mRNA in most investigated samples of GBM, anaplastic astrocytoma, and some other tumors. Complete lack of expression of TSC-22 occurred in one sample of anaplastic astrocytoma, as well as in meningioma, brain sarcoma, sarcomatous meningioma, and oligodendroglioma. The differential expression of TSC-22 gene was confirmed by semiquantitative RT-PCR in 15 samples of astrocytomas WHO grade II-IV and three samples of normal brain. CONCLUSIONS: Significantly decreased levels of TSC-22 mRNA in human brain and salivary gland tumors and antiproliferative role of TSC-22 strongly suggest a tumor suppressor role for TSC-22. J. [less ▲]

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See detailOccurrence of sulphides on the bornite-idaite join from Vielsalm, Stavelot Massif, Belgium
Hatert, Frédéric ULiege

in European Journal of Mineralogy (2003), 15(6, NOV-DEC), 1063-1068

Sulphides with chemical compositions between idaite and bornite have been identified from several quartz veins crosscutting Ordovician schists in Vielsalm, Belgium. Idaite is an oxidation product of ... [more ▼]

Sulphides with chemical compositions between idaite and bornite have been identified from several quartz veins crosscutting Ordovician schists in Vielsalm, Belgium. Idaite is an oxidation product of bornite, and occurs in the more oxidised parts of the quartz veins. The alteration sequence bomite --> "anomalous bornite" --> idaite is observed, associated with the growth of chalcopyrite lamellae parallel to the {100} and {111} directions of precursor bornite. Electron microprobe analyses indicate a chemical composition significantly enriched in Cu, when compared with the ideal composition of idaite, Cu3FeS4, as well as a progressive compositional evolution from bomite to idaite. The X-ray powder pattern is indexed in the space group I (4) over bar 2m, similar to that of stannite, and gives the unit-cell parameters a = 5.279(4) and c = 10.47(2) Angstrom. [less ▲]

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See detailSolar-blind diamond detectors for LYRA, the solar VUV radiometer on board PROBA II
Benmoussa, A.; Hochedez, J. F.; Schmutz, W. K. et al

in Experimental Astronomy (2003), 16(3), 141-148

Fabrication, packaging and experimental results on the calibration of metal-semiconductor-metal (MSM) photodetectors made on diamond are reported. LYRA (Lyrnan-alpha RAdiometer onboard PROBA-2) will use ... [more ▼]

Fabrication, packaging and experimental results on the calibration of metal-semiconductor-metal (MSM) photodetectors made on diamond are reported. LYRA (Lyrnan-alpha RAdiometer onboard PROBA-2) will use diamond detectors for the first time in space for a solar physics instrument. A set of measurement campaigns was designed to obtain the XUV-to-VIS responsivity of the devices and other characterizations. The measurements of responsivity in EUV and VUV spectral ranges (40-240 nm) have been carried out by the Physkalisch-Technische Bundesanstalt (PTB) in Germany at the electron storage ring BESSY II. The longer wavelength range from 210 to 1127 nm was measured with monochromatic light by using a Xe-lamp at IMO-IMOMEC. The diamond detectors exhibit a photoresponse which lie in the 35-65 mA/W range at 200 nm (corresponding to an external quantum efficiency of 20-40%) and indicate a visible rejection ratio (200-500 nm) higher than four orders of magnitude. [less ▲]

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See detailPrincipal component analysis of Piezo-Sensor Array for damage localization
De Boe, Pascal; Golinval, Jean-Claude ULiege

in Structural Health Monitoring (2003), 2(2), 137-144

This paper focuses on applying statistical process control techniques, based on principal component analysis, to vibration-based damage diagnosis. It is well known that localized structural damages with ... [more ▼]

This paper focuses on applying statistical process control techniques, based on principal component analysis, to vibration-based damage diagnosis. It is well known that localized structural damages with relative small amplitude do not affect much the global modal response of the structure, at least at low frequencies. Nevertheless, it can be expected that the local dynamic behavior of a damaged structural subcomponent is significantly affected. Assuming that each structural subcomponent is monitored, local structural damage, with relative small amplitude, will only affect a particular sensor without affecting significantly the response of the others. By applying a principal component analysis on the sensor time responses, it is possible to see that any change of one particular sensor will affect the subspace spanned by the complete sensor response set. The subspace corresponding to the damaged structure can then be compared with the subspace of an initial state in order to diagnose possible damage. The principal component analysis may also be performed for every potential subset of damaged sensors in order to identify the involved sensor, and, therefore, the damaged structural component. The spatial information given by the distributed sensors (e.g. piezoelectric laminates) can be used to forecast structural damages on a critical area but damage localization is also possible with classical sensors (e.g. accelerometers). The damage may be located as the errors attain the maximum at the sensors instrumented in the damaged substructures. [less ▲]

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See detailLa varicelle et le zona ou les mystères de la latence d'un virus et de sa réactivation
Rentier, Bernard ULiege

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2003), 158(3-4), 169-73174-5

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features: chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological ... [more ▼]

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features: chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological features of these diseases such as complications of chicken pox, viral latency in sensory ganglia and reactivation as shingles with concurrent and possibly subsequent prolonged pain, are the sequels of the invasion of the peripheral nervous system during primary infection. Prevention is achieved by vaccination with a live attenuated virus strain and therapy calls for specific antiviral agents. In many respects, vzv behaves differently from close relatives. In particular, viral latency in the nervous system is basically different from that of other Herpesviridae. The recent discovery of the expression of some viral regulatory proteins during latency, although it had always been considered that vzv latency was silent, and demonstration that these proteins are immunogenic open new avenues concerning the immune control of vzv reactivation. [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULiege; De Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Pratique Vétérinaire Equine (2003), 35(139), 23-29

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ... [more ▼]

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ipratropium bromide have been tested. This study is to evaluate the efficacy of the synthetic antimuscarinic compound glycopyrrolate as a bronchodilator in horses. Respiratory crisis was induced in seven allergic horses by exposure to natural allergens. Prior to the study, it was established that the attack could be stopped using intravenous atropine sulphate. Pulmonary function tests (ventilation and arterial blood gas analysis) were performed on the horses before and then after aerosol administration of 1500 µg of glycopyrrolate (Robinul®). The attack was characterised by an increase in total pulmonary resis¬tance and maximum pleural pressure variation and by decreased compliance. This study demonstrates that glycopyrrolate exhibits affects that are just as rapid and effective as intravenous atropine or aerosol administration of 1200 µg dry powder Ipratropium. In addi¬tion the treatment was well tolerated and no side-effects were observed in contrast to those seen with intravenous administration of atro¬pine. Therefore this drug has an important role to play among the therapeutics available to practitioners for acute respiratory attacks in horses [less ▲]

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See detailUse of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury
Wirth, D.; Christians, E.; Li, Xiang ULiege et al

in Toxicology and Applied Pharmacology (2003), 192(1), 12-20

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection ... [more ▼]

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological changes occurring after Cd intranasal instillation (1 to 100 microg/mouse) was examined. HSF1-deficient mice were used to evaluate the role of this factor in lung protection. Cd instillation caused dose- and time-dependent changes in the respiratory pattern measured by plethysmography (Penh), and significant increases in lactate dehydrogenase (LDH) activity as well as macrophage and neutrophil counts in bronchoalveolar lavage fluids. HS preconditioning induced Hsp overexpression and reduced the Penh (-30%), LDH (-25%), and neutrophil (-55%) responses to subsequent administration of the highest Cd doses (50 and 100 microg) in wild-type mice. HSF1 deficiency abolished the HS response and its protective effect. In the absence of preconditioning, Hsf1(-/-) mice exhibited higher values of Penh (+70%) and LDH activity (+42%) compared with wild-type animals when exposed to the lowest Cd doses. Higher macrophage (+80%) and neutrophil counts (+115%) were recorded whatever the dose. Western blot analyses indicated that lung protection might be related to the kinetics of HSF1-dependent Hsp70 expression. Altogether, our data demonstrate that HS response elicited both by prior HS and by Cd itself moderates pulmonary injuries due to Cd instillation, and that HSF1 is a major mediator in this protection. [less ▲]

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See detailImbalance between lipoxin A(4) and leukotriene B-4 in chronic mastitis-affected cows
Boutet, Philippe ULiege; Bureau, Fabrice ULiege; Degand, Guy ULiege et al

in Journal of Dairy Science (2003), 86(11), 3430-3439

Persistent accumulation of inflammatory cells in the udder, with neutrophils being the predominant cell type, is a characteristic feature of chronic mastitis in dairy cows. Leukotriene (LT) B-4 is a ... [more ▼]

Persistent accumulation of inflammatory cells in the udder, with neutrophils being the predominant cell type, is a characteristic feature of chronic mastitis in dairy cows. Leukotriene (LT) B-4 is a potent chemotactic agent, known to induce recruitment and accumulation of neutrophils in the bovine mammary gland. The LTB4-stimulated neutrophil functional responses are closely opposed by lipoxin (LX) A(4), which promotes the resolution of inflammation. We thus hypothesized that the chronic inflammation of the udder could be associated with an unfavorable ratio between these two eicosanoids and that the persistence of neutrophil accumulation could be due to an increase in LTB4 synthesis and/or an impaired LXA(4) production. In an attempt to verify this hypothesis, we first measured LXA(4), LTB4, and their ratio in the milk of healthy and acute and chronic mastitis-affected quarters. Next, we studied the relationships between these variables and the degree of udder inflammation as assessed by somatic cell count measurement. The LTB4 concentration was low in healthy quarters, drastically increased in acute mastitis, and reached intermediate levels in chronic mastitis-affected quarters. However, whereas LXA(4) concentration was highly increased in acute mastitis, healthy and chronic quarters had similarly low values. The LXA(4):LTB4 ratio was thus significantly lower in chronic mastitis-affected cows. The LTB4 concentrations measured in chronic quarters were highly correlated to somatic cell count and to milk neutrophil and macrophage numbers. A weaker correlation was observed between LXA(4) and these variables. For both eicosanoids, the highest correlation was observed with the number of neutrophils. These results show the existence of an LXA(4):LTB4 imbalance in chronic mastitis-affected cows because of low LXA(4) concentrations. Further studies are needed to determine whether administration of LX or stable analogs could have therapeutic potential in the control of chronic bovine mastitis. [less ▲]

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See detailCarbon and nitrogen isotopic ratios of the seagrass Posidonia oceanica: Depth-related variations
Lepoint, Gilles ULiege; Dauby, Patrick ULiege; Fontaine, Michael ULiege et al

in Botanica Marina (2003), 46(6), 555-561

Nitrogen (delta(15)N) and carbon (delta(13)C) isotopic compositions of Posidonia oceanica were determined during three seasons along a bathymetric gradient (438 m depth).The delta(15)N values are low (2.2 ... [more ▼]

Nitrogen (delta(15)N) and carbon (delta(13)C) isotopic compositions of Posidonia oceanica were determined during three seasons along a bathymetric gradient (438 m depth).The delta(15)N values are low (2.2+/-0.9%) and variable.They do not show any relation to depth or sampling dates. There is a significant difference between the delta(15)N values of the youngest and the oldest leaves, probably as a result of N resorption and senescing during leaf ageing. The delta(13)C values of young Posidonia leaves vary with depth, showing the relationship between delta(13)C values and primary productivity rate, and the use of a bicarbonate/CO2 mixture as an inorganic carbon source. The delta(13)C values of the oldest P. oceanica leaves are depleted in C-13 compared to those of young leaves. This modification of the C-13 signatures in relation to leaf age is particularly important between 20 and 29 m depth. This modification could be related to photosynthetic rate change during ageing, but also to change in carbohydrate composition and content. [less ▲]

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See detailApproximation algorithms for the design of SDH/SONET networks
Brauner, Nadia; Crama, Yves ULiege; Finke, Gerd et al

in RAIRO : Operations Research = Recherche Opérationnelle (2003), 37(4, OCT-DEC), 235-247

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this ... [more ▼]

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this problem efficiently in practice, fast greedy algorithms and a tabu-search method are proposed and analyzed by means of an experimental study. [less ▲]

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See detailRole of catalase in ethanol-induced conditioned taste aversion : a study with 3-amino-1,2,4-triazole
Quertemont, Etienne ULiege; Escarabajal, M. Dolores; De Witte, Philippe

in Drug and Alcohol Dependence (2003), 70(1), 77-83

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain ... [more ▼]

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain metabolism of ethanol by the enzyme catalase. Therefore, the inhibition of catalase by 3-amino-1,2,4-triazole (aminotriazole) may help to clarify the involvement of acetaldehyde in ethanol's hedonic effects. In the present study, multiple doses of both ethanol and aminotriazole were used to investigate the effects of catalase inhibition on ethanol-induced conditioned taste aversion (CTA). A separate microdialysis experiment investigated the effects of aminotriazole pretreatment on the time course of brain ethanol concentrations. Ethanol induced a dose-dependent CTA with a maximal effect after conditioning with 2.0 g/kg ethanol. Aminotriazole pretreatments dose-dependently potentiated the CTA induced by 1.0 g/kg ethanol. However, aminotriazole pretreatments did not alter the CTA induced by higher ethanol doses (1.5 and 2.0 g/kg) probably because a maximal aversion for saccharin was already obtained without aminotriazole. The results of the microdialysis experiment confirmed that the effects of aminotriazole cannot be attributed to local alterations of brain ethanol levels. The present study argues against a role for brain acetaldehyde in ethanol's aversive effects but in favor of its involvement in ethanol rewarding properties. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailLe médecin, la trousse et le livre dans le monde gréco-romain
Marganne, Marie-Hélène ULiege

in Papyrologica Lupiensia (2003), 12

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Delarge, J. et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003)

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See detailObscure Sorrow Hill, The Caribbean Source of Wilson Harris's Fiction
Maes-Jelinek, Hena ULiege

in Caribbean Writer (The) (2003), 17

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See detailInvestigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry
Pochet, L.; Dieu, M.; Frederick, R. et al

in Tetrahedron (2003)

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See detailLes apports du projet Johns Hopkins dans la statistique du non-marchand
Mertens de Wilmars, Sybille ULiege

in Non Marchand : Management, Droit et Finance (2003), (11), 29-38

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See detailLa climatologie
Erpicum, Michel ULiege; Alexandre, Jean ULiege

in Bulletin de la Société Géographique de Liège (2003), 43(2003), 79-88

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See detailNitric oxide synthase inhibition lowers activity of neurons with meningeal input in the rat spinal trigeminal nucleus
De Col, R.; Koulchitsky, Stanislav ULiege; Messlinger, K. B.

in Neuroreport (2003), 14(2), 229-32

Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn and the spinal trigeminal nucleus, where nociceptive information from extra- and intracranial tissues ... [more ▼]

Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn and the spinal trigeminal nucleus, where nociceptive information from extra- and intracranial tissues is processed. Extracellular impulse activity was recorded from neurons in the rat spinal trigeminal nucleus with afferent input from the cranial dura mater. In contrast to the inactive isomer D-NAME, infusion of the nitric oxide synthase inhibitor L-NAME (20 mg/kg) significantly reduced neuronal activity and increased systemic blood pressure. It is concluded that nitric oxide production contributes to the ongoing activity of sensitized neurons in the spinal trigeminal nucleus. The results suggest that nitric oxide may be involved in the generation and maintenance of primary headaches such as migraine. [less ▲]

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See detailClearance of a productive lentivirus infection in calves experimentally inoculated with caprine arthritis-encephalitis virus
Morin, T.; Guigen, F.; Bouzar, Amel ULiege et al

in Journal of Virology (2003)

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See detailHC gp-39 gene is upregulated in glioblastomas.
Shostak, Kateryna ULiege; Labunskyy, Vyacheslav; Dmitrenko, Vladimir et al

in Cancer Letters (2003), 198(2), 203-10

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression ... [more ▼]

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression (SAGE). Analysis revealed HC gp-39 among the genes with the most pronounced changes of expression in tumor cells. Northern hybridization confirmed the results of computer analysis and showed that enhanced expression of the HC gp-39 gene was mainly in GBMs and occasionally in anaplastic astrocytomas. Neither SAGE nor Northern analysis revealed the presence of HC gp-39 mRNA in the glioblastoma cell line, thus the detection of increased quantities of this mRNA in GBMs may be associated with activated macrophages. Since the numbers of infiltrating macrophages and small vessel density are higher in glioblastomas than in anaplastic astrocytomas or astrocytomas, the HC gp-39 gene can be used as a molecular marker in the analysis of malignant progression of astrocytic gliomas. [less ▲]

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULiege et al

in Acta Crystallographica (2003)

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See detailIntérêt du monitoring continu du glucose interstitiel chez le patient diabétique de type 1
RADERMECKER, Régis ULiege; Sélam, Jean-Louis; SCHEEN, André ULiege

in Revue Médicale Suisse (2003), 61

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See detailLow T-cell chimerism is not followed by graft rejection after nonmyeloablative stem cell transplantation (NMSCT) with CD34-selected PBSC.
Baron, Frédéric ULiege; Baudoux, Etienne ULiege; Frere, Pascale ULiege et al

in Bone Marrow Transplantation (2003), 32(8), 829-34

We investigate the feasibility of CD34-selected peripheral blood stem cell (PBSC) transplantation followed by pre-emptive CD8-depleted donor lymphocyte infusions (DLI) after a minimal conditioning regimen ... [more ▼]

We investigate the feasibility of CD34-selected peripheral blood stem cell (PBSC) transplantation followed by pre-emptive CD8-depleted donor lymphocyte infusions (DLI) after a minimal conditioning regimen. Six patients with advanced hematological malignancies ineligible for a conventional myeloablative transplant (n=5) or metastatic renal cell carcinoma (n=1), and with an HLA-identical (n=4) or alternative (n=2) donor were included. The nonmyeloablative conditioning regimen consisted in 2 Gy TBI alone (n=4), 2 Gy TBI and fludarabine (RCC patient, n=1) or cyclophosphamide and fludarabine (patient who had previously received 12 Gy TBI, n=1). Post transplant immunosuppression was carried out with cyclosporin (CyA) and mycophenolate mofetil (MMF). Initial engraftment was achieved in all patients. One out of six patients (17%) experienced grade > or =2 acute GVHD only after abrupt cyclosporin discontinuation and alpha interferon therapy for life-threatening tumor progression. T-cell chimerism was 23% (19-30) on day 28, 32% (10-35) on day 100, 78% (49-95) on day 180 and 99.5% (99-100) on day 365. Three out of four patients who had measurable disease before the transplant experienced a complete response. We conclude that CD34-selected NMSCT followed by CD8-depleted DLI is feasible and preserves engraftment and apparently also the graft-versus-leukemia (GVL) effect. Further studies are needed to confirm this encouraging preliminary report. [less ▲]

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See detailRéférences et issues des accouchements au Kivu, République démocratiquedu Congo
Mugisho, E; Dramaix, M; Porignon, Denis ULiege et al

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2003), 51(2), 237-244

BACKGROUND: The process of referral between the first and the second level of the health system in the Democratic Republic of Congo is poorly understood. This report intends to study the association ... [more ▼]

BACKGROUND: The process of referral between the first and the second level of the health system in the Democratic Republic of Congo is poorly understood. This report intends to study the association between the referral and the hospital perinatal outcomes. METHODS: Delivery outcomes in a retrospective cohort of 1162 women admitted between June 95 and May 96, in two referral hospitals in Kivu were analyzed according to the referral status and the women's characteristics. RESULTS: Forty-three percent (n=492)of women admitted, corresponding to 2.3% of expected pregnant women, were referred. Referred women had higher risks of obstetrical complications (OR=2.0; CI95%: 1.3-3.1) and intervention (OR=1.5; CI95%: 1.0-2.3) and similar risks of low birth weight and perinatal mortality. Women with complications during the antenatal period had a double risk of intervention and perinatal mortality. The risk of obstetrical intervention was lower when women had attended 2 visits (OR=0.5; CI95%: 0.3-0.8); the risk of low birth weight was lowest only for mothers who had attended one visit (OR=0.5; CI95%: 0.3-0.9). Distance > or =90 minutes walking from home to hospital raised the risk of obstetrical complication (OR=1.7; CI95%: 1.1-2.5), the risk of obstetrical intervention (OR=1.5; CI95%: 1.0-2.1), and the risk of perinatal mortality (OR=1.6; CI95%: 1.0-2.7). Late admission raised the risk of perinatal mortality (OR=1.8; CI95%: 1.2-2.9) and lowered the risk of obstetrical complication (OR=0.7; CI95%: 0.5-1.0). Part payment of care was associated with higher risks of low birth weight (OR=1.9; CI95%: 1.3-2.9), perinatal mortality (OR=2.2; CI95%: 1.4-3.5) and obstetrical intervention (OR=2.4; CI95%: 1.7-3.4). CONCLUSION: These results suggest a deficit of referred cases considering that 15% of pregnant women in the area covered by the referral hospitals should have been referred. They confirm the negative influence of economic and geographic constraints on the delivery outcomes. They point out the relevance of making reorganization of the referral system a priority. [less ▲]

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See detailWithin-herd effects of age at test day and lactation stage on test-day yields
Bormann, J.; Wiggans, G. R.; Druet, Tom ULiege et al

in Journal of Dairy Science (2003), 86(11), 3765-3774

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve ... [more ▼]

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve the accuracy of estimation. Test-day data starting with 1990 calvings for the entire US Jersey population and Holsteins from California, Pennsylvania, Wisconsin, and Texas were analyzed. Test-day yields were adjusted for across-herd effects using solutions from a regional analysis. Estimates of the relative variance ( fraction of total variance) due to within-herd age effects were small, indicating that regional adjustments for age were adequate. The relative variances for within-herd lactation stage were large enough to indicate that accuracy of genetic evaluations could be improved by including herd stage effects in the model for milk, fat, and protein, but not for somatic cell score. Because the within-herd lactation stage effect is assumed to be random, the effect is regressed toward the regional effects for small herds, but in large herds, lactation curves become herd specific. Model comparisons demonstrated the greater explanatory power of the model with a within-herd-stage effect as prediction error standard deviations were greater for the model without this effect. The benefit of the within-herd-stage effects was confirmed in a random regression model by comparing variance components from models with and without random within-herd regressions and through log-likelihood ratio tests. [less ▲]

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See detailLe système d'échange de quotas d'émissions de gaz à effet de serre dans la Communauté européenne
Pâques, Michel ULiege

in Aménagement - Environnement (2003)

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See detailEmissions of ammonia, nitrous oxide, methane, carbon dioxide and water vapor in the raising of weaned pigs on straw-based and sawdust-based deep litters
Nicks, Baudouin ULiege; Laitat, Martine ULiege; Vandenheede, Marc ULiege et al

in Animal Research (2003), 52(3, MAY-JUN), 299-308

Five successive batches of 40 weaned pigs were raised on deep litter of sawdust or straw without changing the litter in between batches. The quantity of litter dry matter utilized in the two cases was 5 ... [more ▼]

Five successive batches of 40 weaned pigs were raised on deep litter of sawdust or straw without changing the litter in between batches. The quantity of litter dry matter utilized in the two cases was 5 kg per pig. The concentrations of gases were measured 8 times, at about one-month intervals, for 6 consecutive days and the ventilation flow was recorded continuously. Pig raising on saw-dust-based litter differed from that with straw by an emission of 2.6 times less ammonia (0.46 vs. 1.21 g per pig per day), 2.1 times less methane (0.77 vs. 1.58 g per pig per day), 3.9 times more N2O (1.39 vs. 0.36 g per pig per day), 4% more CO2 (481 vs. 463 g per pig per day) and 21% more H2O (1126 vs. 933 g per pig per day). All differences were significant. About 58% of the nitrogen excreted by the pigs was recovered in the gas form and for the two litters, about 79% in the form of N-2. [less ▲]

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See detailL'importance économique du bénévolat associatif en Belgique
Mertens de Wilmars, Sybille ULiege

in Non Marchand : Management, Droit et Finance (2003), (11), 9-22

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See detailEffect of residence time on the efficacy of antidandruff shampoos.
Pierard, Claudine ULiege; Uhoda, Emmanuelle ULiege; Loussouarn, G. et al

in International Journal of Cosmetic Science (2003), 25(6), 267-71

Dandruff is known to be controlled by fungistatic shampoos active against Malassezia spp. These products also remove the loosely attached scales. This study was performed to assess the effect of a 5-min ... [more ▼]

Dandruff is known to be controlled by fungistatic shampoos active against Malassezia spp. These products also remove the loosely attached scales. This study was performed to assess the effect of a 5-min residence time on the efficacy of antidandruff shampoos. Two commercially available shampoos were used in two groups of 21 panelists with severe dandruff. They contained either 1% ketoconazole or 1% piroctone olamine. In each group, intraindividual comparisons were made by a split-scalp design between the effect of a 5-min residence time versus no residence time. Both shampoos induced significant reductions in scaliness and yeast colonization. The beneficial effects were obvious immediately after one single shampooing and 3 days later as well. The improvement was greater with a 5-min residence time. The piroctone olamine treatment benefited more than the ketoconazole treatment from the extension of shampoo-exposure time. In conclusion, the benefit of a residence time in treating dandruff is documented. The level of improvement in efficacy may vary according to the nature of the shampoo. [less ▲]

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See detailEfficacité du piégeage, par les méthodes classiques, des coléoptères saproxyliques en Région wallonne (Belgique)
Lhoir, Jonathan; Fagot, Jean ULiege; Thieren, Yves et al

in Notes Fauniques de Gembloux (2003), 50

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont ... [more ▼]

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont (Daverdisse village). Both forests are caracterized by a large amount of dead wood standing and laying down. The trapping's results are presented, with regards on the different technics used, on the differences between sites, on the beetles families and their saproxylic behavior. [less ▲]

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See detailMoins-values et plus-values d'urbanisme: La révision de l'article 70 du CWATUP
Pâques, Michel ULiege

in Revue du Notariat Belge (2003)

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See detailApport à la connaisance du genre Rhizophagus Herbst, 1793 (Coleoptera: Clavicornia Monotomidae) en région wallonne (Belgique)
Thieren, Yves; Fagot, Jean ULiege; Lhoir, Jonathan et al

in Notes Fauniques de Gembloux (2003), 50

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations ... [more ▼]

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations between species and trapping methods and on the species activity during the six months trapping. Waiting for an exhaustive revision of the genera, a primary point is made on the Rhizophagus in Belgium and a prime list is given with a lot of ethological considerations. [less ▲]

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See detailHow ergodic is the fragmentation of the pyridine cation? A maximum entropy analysis
Gridelet, E.; Locht, Robert ULiege; Lorquet, Andrée ULiege et al

in International Journal of Mass Spectrometry (2003), 228(2-3), 389-402

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the ... [more ▼]

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the reaction threshold. This extends our previous study limited to the metastable domain [Int. J. Mass Spectrom. Ion Process. 185/186/187 (1999) 155]. Retarding potential curves resulting from dissociative photoionization using the He(I), Ne(I), and Ar(II) resonance lines have been analyzed by the maximum entropy method. The comparison between the experimentally measured curves and those calculated for the prior (i.e., most statistical) situation reveals the existence of dynamical constraints that prevent phase space from being fully explored. The "ergodicity index" F(E) that measures the efficiency of phase space sampling as a function of the internal energy E of the molecular ion is found to decrease steadily as a function of E and to level off at a value of about 50% when E greater than or equal to 2.5 eV At these high internal energies where phase space exploration no longer decreases, spontaneous intramolecular vibrational energy redistribution (i.e., resulting from the anharmonicity of the molecular vibrations) is thought to contribute to internal energy randomization to a limited extent only. When the lifetime is short, phase space exploration is believed to result instead from the relaxation of the electronic energy via a cascade of non-radiative transitions, which leads to a great diversity of initial conditions, and thus, contributes to statisticity. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detail« Comment servir le souverain ». A propos d’un traité pseudo-platonicien inédit
Bauden, Frédéric ULiege; Ghersetti, Antonella

in Quaderni di Studi Arabi (2003), 20-21

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