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See detailPrévention des cancers cutanés par les crèmes de protection solaire.
Uhoda, I.; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(8), 505-8

How do sunscreens protect against skin cancers? The answer to this question is a matter of controversy among scientist for several years. The doubt persists because the wise use of such products is only ... [more ▼]

How do sunscreens protect against skin cancers? The answer to this question is a matter of controversy among scientist for several years. The doubt persists because the wise use of such products is only one of the factors involved in sun behavior together with avoiding excessive sunlight exposure and wearing protective clothes. [less ▲]

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See detailPrévention et traitement des nausées et vomissements après chimiothérapie anticancéreuse
Brasseur, Edmond ULg; Silvestre, Rose-Marie; Jerusalem, Guy ULg et al

in Médecine et Hygiène (2002), 60

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See detailEcueils et chausse-trapes.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 249

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See detailEffect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses
Kirschvink, Nathalie; Smith, N.; Fievez, Laurence ULg et al

in Equine Veterinary Journal (2002), 34(6), 563-571

In heaves-affected horses the relation between oxidant status, airway inflammation (AI) and pulmonary function (PF) is unknown. The oxidant status of blood and pulmonary epithelial lining fluid (PELF) of ... [more ▼]

In heaves-affected horses the relation between oxidant status, airway inflammation (AI) and pulmonary function (PF) is unknown. The oxidant status of blood and pulmonary epithelial lining fluid (PELF) of healthy (H, n = 6) and heaves-affected horses in clinical remission (REM, n = 6) and in crisis (CR, n = 7) was assessed at rest, during and after standardised exercise test by measurement of reduced and oxidised glutathione, glutathione redox ratio [GRR%]; uric acid and 8-epi-PGF2alpha. Oxidant status was related to PF parameters (mechanics of breathing and arterial blood gas tension) and Al parameters (bronchoalveolar lavage [BAL] neutrophil % and AI score). Haemolysate glutathione was significantly different between groups and was correlated with PF and AI parameters; GRR in PELF was increased during CR and was correlated with PF and AI parameters. Exercise induced an increase of plasma uric acid that was significantly higher both in REM and CR. PELF 8-epi-PGF2alpha was significantly increased in CR and correlated with PF and AI parameters. These results suggest that oxidative stress occurring in heaves is correlated with PF and AI and may be locally assessed by PELF glutathione status, uric acid and 8-epi-PGF2alpha. Systemic repercussions are reflected by assay of GSH in resting horses and by uric acid in exercising horses. [less ▲]

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See detailDissociations between categorization and similarity judgements as a result of learning feature distributions
Thibaut, Jean-Pierre; Dupont, Myriam; Anselme, Patrick ULg

in Memory & Cognition (2002), 30(4), 647-656

A dissociation between categorization and similarity was found by Rips (1989). In one experiment, Rips found that a stimulus halfway between a pizza and a quarter was categorized as a pizza but was rated ... [more ▼]

A dissociation between categorization and similarity was found by Rips (1989). In one experiment, Rips found that a stimulus halfway between a pizza and a quarter was categorized as a pizza but was rated as more similar to a quarter. Smith and Sloman (1994) discussed these results in terms of the role of necessary and characteristic features. In two experiments, participants had to learn to categorize novel artificial shapes composed of a nonsalient necessary feature combined with a salient characteristic feature. Participants categorized stimuli on the basis of a necessary feature, whereas their similarity judgments relied on characteristic features. The role of deep (essential) features in dissociations is considered. Results are discussed in terms of the differences between requirements of categorization and similarity judgments. [less ▲]

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See detailL'hyperglycemie post-prandiale. I. Physiopathologie, consequences cliniques et approaches dietetiques.
Scheen, André ULg; Paquot, Nicolas ULg; Jandrain, Bernard ULg et al

in Revue Médicale de Liège (2002), 57(3), 138-41

Postprandial hyperglycaemia depends on the amount and type of ingested carbohydrates and/or the degree of inhibition of hepatic glucose output following a meal. The kinetics of carbohydrate absorption is ... [more ▼]

Postprandial hyperglycaemia depends on the amount and type of ingested carbohydrates and/or the degree of inhibition of hepatic glucose output following a meal. The kinetics of carbohydrate absorption is directly influenced by the type of food (carbohydrates with variable glycaemic indices, fibre content of the meal) and by the speed of gastric emptying. Hepatic glucose output is remarkably inhibited by insulin and strongly stimulated by glucagon. It remains abnormally high after a meal in diabetic patients because of insufficient portal insulin concentrations, hepatic insulin resistance and/or hyperglucagonaemia. In diabetic patients, postprandial hyperglycaemia contributes to the aggravation of chronic hyperglycaemia, and thus to the increase of glycated haemoglobin levels. Furthermore, it has been recently demonstrated that postprandial hyperglycaemia increases the cardiovascular risk, even in nondiabetic subjects, probably by inducing endothelial dysfunction. Appropriate dietary counselling plays a key-role in the control of postprandial hyperglycaemia. Generally speaking, it includes a selection of carbohydrates with low glycaemic index and a higher fibre intake. Pharmacological interventions may also be considered when necessary. [less ▲]

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See detailCoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.
Piret, Jean-Pascal; Mottet, Denis ULg; Raes, Martine et al

in Annals of the New York Academy of Sciences (2002), 973

HIF-1 (hypoxia-inducible factor-1) is the major transcription factor that is specifically activated during hypoxia. This transcription factor is composed of two subunits: HIF-1alpha and ARNT (aryl ... [more ▼]

HIF-1 (hypoxia-inducible factor-1) is the major transcription factor that is specifically activated during hypoxia. This transcription factor is composed of two subunits: HIF-1alpha and ARNT (aryl hydrocarbon receptor nuclear translocator). ARNT is constitutively expressed, whereas HIF-1alpha is targeted to proteasome degradation by ubiquitination during normoxia. In hypoxia, HIF-1alpha is stabilized and translocates to the nucleus, where it binds to ARNT. The active HIF-1 induces expression of various genes whose products play an adaptive role to the new conditions induced by hypoxia. Besides the role played by HIF-1 in the adaptation to hypoxia, recent data describe a possible role for HIF-1 in the modulation of apoptosis. According to some authors, hypoxia induces apoptosis. However, it has also been reported that hypoxia could protect cells against apoptotic cell death induced by various agents such as serum deprivation and incubation in the presence of chemotherapy agents. These contradictory data suggest that HIF-1 could display either a proapoptotic or an antiapoptotic role according to the conditions. In order to study how HIF-1 can modulate apoptosis, we studied whether hypoxia or cobalt chloride, a chemical inducer of HIF-1, could influence apoptosis induced by tert-butyl hydroperoxide (t-BHP), serum deprivation, or both in hepatoma cell line HepG2. HepG2 cells were incubated 8 hours under normoxia or hypoxia in the presence of t-BHP with or without CoCl2. CoCl2 reduced the apoptotic death of HepG2 cells induced by t-BHP and serum deprivation, as measured by DNA fragmentation. This effect was confirmed by measurement of the caspase activity. Moreover, hypoxia also prevented t-BHP- or serum deprivation-induced DNA fragmentation and caspase activation-however, to a lower extent than CoCl2. These different data suggest a possible antiapoptotic role of HIF-1. More experiments are needed to define if HIF-1 actually plays an active role in cell death protection and to determine the exact mechanism underlying this effect. [less ▲]

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See detailWilliam S. Burroughs: Du cut-up au simulacre
Claisse, Frédéric ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2002), (94-95-96), 151-174

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See detailLe beau et l’idée du beau: Les mots pour le dire
Winand, Jean ULg

in Beautés d’Égypte (2002)

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See detailL'hyperglycemie post-prandiale. II. Approches therapeutiques medicamenteuses.
Scheen, André ULg; Letiexhe, Michel ULg; Geronooz, I. et al

in Revue Médicale de Liège (2002), 57(4), 196-201

Besides dietary approaches, various pharmacological means have been recently developed in order to better control postprandial hyperglycaemia. This objective may be obtained: 1) by slowing down the ... [more ▼]

Besides dietary approaches, various pharmacological means have been recently developed in order to better control postprandial hyperglycaemia. This objective may be obtained: 1) by slowing down the intestinal absorption of carbohydrates; 2) by insuring a better insulin priming soon after the meal; and 3) by inhibiting post-prandial glucagon secretion or action. Some hormones (amylin, glucagon-like peptide-1) can slow gastric emptying while alpha-glucosidase inhibitors (acarbose, miglitol) retard intestinal digestion and resorption of complex carbohydrates. A more physiological post-meal profile of insulin may be obtained in type 2 diabetes by using new insulin secretagogues of the glinide family (repaglinide, nateglinide) with an earlier and shorter insulinotropic action or, mainly in type 1 diabetes but also in type 2 diabetes, by using short-acting insulin analogues (lispro. Asp B28) or inhated insulin the action of which is faster than that of subcutaneous insulin. Post-prandial glucagon secretion can be inhibited by amylin. GLP-1 or insulin while other glucagon antagonists are currently in development. [less ▲]

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See detailLe mélange épicéa-douglas, une association intéressante pour le sylviculteur ? 1ère partie
Colson, Vincent ULg; Claessens, Hugues ULg; Pauwels, D. et al

in Silva Belgica (2002), 109(3), 34-38

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See detailThe role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell
Dremier, S.; Coulonval, K.; Perpete, S. et al

in Annals of the New York Academy of Sciences (2002), 968

Cyclic AMP has been shown to inhibit cell proliferation in many cell types and to activate it in some. The latter has been recognized only lately, thanks in large part to studies on the regulation of ... [more ▼]

Cyclic AMP has been shown to inhibit cell proliferation in many cell types and to activate it in some. The latter has been recognized only lately, thanks in large part to studies on the regulation of thyroid cell proliferation in dog thyroid cells. The steps that led to this conclusion are outlined. Thyrotropin activates cyclic accumulation in thyroid cells of all the studied species and also phospholipase C in human cells. It activates directly cell proliferation in rat cell lines, dog, and human thyroid cells but not in bovine or pig cells. The action of cyclic AMP is responsible for the proliferative effect of TSH. It accounts for several human diseases: congenital hyperthyroidism, autonomous adenomas, and Graves' disease; and, by default, for hypothyroidism by TSH receptor defect. Cyclic AMP proliferative action requires the activation of protein kinase A, but this effect is not sufficient to explain it. Cyclic AMP action also requires the permissive effect of IGF-1 or insulin through their receptors, mostly as a consequence of PI3 kinase activation. The mechanism of these effects at the level of cyclin and cyclin-dependent protein kinases involves an induction of cyclin D3 by IGF-1 and the cyclic AMP-elicited generation and activation of the cyclin D3-CDK4 complex [less ▲]

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See detailÉtude dendrométrique d’Acacia auriculiformis A. Cunn. ex Benth. en mélange sur vertisol au Bénin
Fonton, N. H.; Glele Kakai, R.; Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(1), 29-37

Acacia auriculiformis is a fast growing species planted on vertisols in Benin. An inventory of 11 mixed stands of Acacia, which are 7 to 9 years old, has been realized to estimate growth parameters of the ... [more ▼]

Acacia auriculiformis is a fast growing species planted on vertisols in Benin. An inventory of 11 mixed stands of Acacia, which are 7 to 9 years old, has been realized to estimate growth parameters of the stands. The present study shows that, for the dendrometrical parameters, there is no difference between species associations at a 0.05 significance level. Nevertheless, the largest values of quadratic mean diameter of the stems foot are observed in the species associations including Leucaena leucocephala. Moreover, the branch volume decreases with the increasing of the number of stems per tree. The most appropriate volume function for Acacia auriculiformis is the one that takes into account the diameter of the stems foot and the total height. Otherwise, the species associations do not influence the profile of Acacia trees, which is constant within the associations. The predicted conversion and cutting coefficients show that the stacked wood volume represents about 144 % of the real stand volume. [less ▲]

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See detailPhylogeny of the genus Apodemus with a special emphasis on the subgenus Sylvaemus using the nuclear IRBP gene and two mitochondrial markers: cytochrome b and 12S rRNA.
Michaux, Johan ULg; Chevret, P.; Filippucci, M*-G et al

in Molecular Phylogenetics & Evolution (2002), 23(2), 123-36

Phylogenetic relationships among 17 extant species of Murinae, with special reference to the genus Apodemus, were investigated using sequence data from the nuclear protein-coding gene IRBP (15 species ... [more ▼]

Phylogenetic relationships among 17 extant species of Murinae, with special reference to the genus Apodemus, were investigated using sequence data from the nuclear protein-coding gene IRBP (15 species) and the two mitochondrial genes cytochrome b and 12S rRNA (17 species). The analysis of the three genes does not resolve the relationships between Mus, Apodemus, and Rattus but separates Micromys from these three genera. The analysis of the two mitochondrial regions supported an association between Apodemus and Tokudaia and indicated that these two genera are more closely related to Mus than to Rattus or Micromys. Within Apodemus, the mitochondrial data sets indicated that 8 of the 9 species analyzed can be sorted into two main groups: an Apodemus group, with A. agrarius, semotus, and peninsulae, and a Sylvaemus group, with uralensis, flavicollis, alpicola, sylvaticus, and hermonensis. The position of Apodemus mystacinus is ambiguous and might be either included in Sylvaemus or considered a distinct subgenus, Karstomys, more closely related to Sylvaemus than to Apodemus. Estimation of the divergence time for these taxa suggests a separation between 7 and 8 My ago for the three groups (mystacinus and the two subgenera Apodemus and Sylvaemus). Within each subgenus, divergence times are between 5.4 and 6 My for Apodemus and between 2.2 and 3.5 My for Sylvaemus and mystacinus. [less ▲]

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See detailStructural determinants of cold adaptation and stability in a psychrophilic alpha-amylase
D'Amico, Salvino ULg; Gerday, Charles ULg; Feller, Georges ULg

in Biologia (2002), 57(Suppl. 11), 213-219

The heat-labile alpha-amylase from an Antarctic bacterium is the largest known protein that unfolds reversibly according to a two-state transition, as shown by differential scanning calorimetry. Mutants ... [more ▼]

The heat-labile alpha-amylase from an Antarctic bacterium is the largest known protein that unfolds reversibly according to a two-state transition, as shown by differential scanning calorimetry. Mutants of this enzyme were produced, carrying intended additional weak interactions of a type found in thermostable alpha-amylases. It is shown that single amino acid side chain substitutions can significantly modify the melting point T-m, the calorimetric enthalpy DeltaH(cal), the cooperativity and reversibility of unfolding, the thermal inactivation rate constant, and the kinetic parameters k(cat) and K-m. Although all mutations were located far from the active site, their overall trend is to decrease both k(cat) and K-m, probably by making the molecule more rigid, but this protects mutants against thermal inactivation. [less ▲]

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See detailFactor XIII a-positive dermal dendrocytes and shear wave propagation in human skin.
Hermanns-Lê, Trinh ULg; Uhoda, I.; Pierard, Claudine ULg et al

in European Journal of Clinical Investigation (2002), 32(11), 847-51

BACKGROUND: The in vivo interdependence between the phenotypic characteristics of dermal cells and the strain imposed on the tissue has not been studied thoroughly in humans. In particular the mechanical ... [more ▼]

BACKGROUND: The in vivo interdependence between the phenotypic characteristics of dermal cells and the strain imposed on the tissue has not been studied thoroughly in humans. In particular the mechanical force modulation of Factor XIII a expression in dermal dendrocytes (DD) remains unknown. MATERIALS AND METHODS: The present study compares the numerical density of Factor XIII a-positive DD and the in vivo shear wave velocity in the skin. The investigation was performed in 20 men of normal weight and 20 obese men before and after entering a slimming process. RESULTS: Excess cutaneous fat places the skin under increased intrinsic tension. The resonance running time measurement (RRTM) and the DD density were significantly reduced in overweight individuals. After a short-term but intense slimming process, the same individuals showed a trend to normalization of these two parameters without, however, reaching significance. Pooling all data yielded a significant logarithmic correlation between RRTM values and densities in Factor XIII a-positive DD. CONCLUSION: Factor XIII a expression in human DD may be partially regulated by the intrinsic resting tensions in the skin. [less ▲]

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See detailStunting may determine the severity of malaria-associated anemia in African children.
Verhoef, Hans; West, Clive E; Veenemans, Jacobien et al

in Pediatrics (2002), 110(4), 48

OBJECTIVE: Evidence from previous studies that malnourished children are protected against malaria is controversial. In individuals repeatedly exposed to malaria, immunity may develop first against severe ... [more ▼]

OBJECTIVE: Evidence from previous studies that malnourished children are protected against malaria is controversial. In individuals repeatedly exposed to malaria, immunity may develop first against severe disease, then against pyrogens, and last, against parasites. If this is true, this would suggest that reduced immune function that may exist in stunted children exacerbates the severity of malarial signs and symptoms, rather than the occurrence of parasitemia. On the other hand, several studies have suggested that malnourished children are protected to some degree against malaria. Our aim was to evaluate whether observational data support the hypothesis that nutritional inadequacies that cause stunting modify the associations between malaria and hematologic indicators such as hemoglobin concentration and serum concentrations of C-reactive protein and soluble transferrin receptor (sTfR). We showed earlier that increased serum concentrations of these receptors in asymptomatic malaria may be explained, at least in part, by increased erythropoiesis to compensate for malaria-induced hemolysis. METHODOLOGY: Community-based cluster survey among Kenyan children aged 2 to 36 months asymptomatic for malaria or anemia (n = 318). RESULTS: When adjusted for age and wasting, the malaria-associated decrease in mean hemoglobin concentration was 8.5 g/L and 15.8 g/L in nonstunted and stunted children, respectively. The malaria-associated increase in geometric mean serum concentrations of sTfR was 1.1-fold and 1.8-fold in nonstunted and stunted children, respectively. The malaria-associated increase in geometric mean serum concentrations of C-reactive protein was 1.4-fold and 2.3-fold in nonstunted and stunted children, respectively. Thus, children with malaria and those who were stunted suffered from more severe anemia and had higher serum concentrations of C-reactive protein and sTfR than would be expected from the combined effect of the 2 working independently. CONCLUSIONS: Our results are consistent with the notion that the nutritional inadequacies causing stunting also impair host immunity, thus increasing the degree to which malaria is associated with decreased concentrations of hemoglobin, with increased inflammation, and with increased iron demand in developing erythroblasts. Increased intake of micronutrients may not only reduce stunting and nutritional anemia, but also reduce malaria-associated anemia. [less ▲]

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See detailThe use of blood pepsinogen as a biomarker of the integrity of the porcine gastric mucosa : A review. Part 1: History, physiopathology of gastric mucosa and different forms of pepsinogens
Banga-Mboko, Henri; Godeau, Jean-Marie ULg; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (2002), 146(6), 339-346

Because the history is defined as the account of the passed events, this manuscript is an Update research on swine pepsinogens since their discovery by Theodor Schwann. Progress was particularly made in ... [more ▼]

Because the history is defined as the account of the passed events, this manuscript is an Update research on swine pepsinogens since their discovery by Theodor Schwann. Progress was particularly made in the localization within the gastric mucosa membrane of the specialized cells involved in the secretion of pepsinogens. These progresses also included identification, isolation purification and the classification of the zymogens. [less ▲]

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See detailSynthesis and ring-opening metathesis polymerization of eight-membered unsaturated lactams and related monomers
Baran, Janusz; Bogdanska, Irena; Jan, Dominique et al

in Journal of Molecular Catalysis A-Chemical (2002), 190(1-févr Sp. Iss. SI), 109-116

Novel eight-membered ring unsaturated lactams were synthesized and tested as monomers for the ruthenium-catalyzed ring-opening metathesis polymerization (ROMP). The reaction of a N-protected cyclic ... [more ▼]

Novel eight-membered ring unsaturated lactams were synthesized and tested as monomers for the ruthenium-catalyzed ring-opening metathesis polymerization (ROMP). The reaction of a N-protected cyclic alkeneamine was also investigated. The Grubbs' benzylidene complexes RuCl2(=CHPh)(PCy3)(2) or RUCl2(=CHPh)(PCy3)(IMesH(2)) and selected ruthenium-arene species bearing either phosphine or stable Arduengo-type N-heterocyclic carbene ligands served as catalyst precursors. In most cases, isomerization of the starting materials took place and only 1-benzyl-1-aza-2-ketocyclooct-5-ene afforded a polymeric product. This polyamide was characterized by numerous analytical techniques. (C) 2002 Elsevier Science B.V All rights reserved. [less ▲]

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See detailCa2+/calmodulin dependent protein kinase regulates GABA activated Cl- current in cockroach dorsal unpaired median neurons
Alix, Philippe ULg; Grolleau, F; Hue, B

in Journal of Neurophysiology (2002), 87

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in ... [more ▼]

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in symmetrical chloride solutions. All DUM neurons voltage-clamped at -50 mV displayed inward currents (I(GABA)) when 10(-4) M of GABA was applied by pneumatic pressure-ejection pulses. The semi-logarithmic curve of I(GABA) amplitude versus the ejection time yielded a Hill coefficient of 4.0. I(GABA) was chloride (Cl-) because the reversal potential given by the current-voltage (I-V) curve varied according to the value predicted by the Nernst equation for Cl- dependence. In addition, I(GABA) was almost completely blocked by bath application of the chloride channel blockers picrotoxin (PTX) or 3,3-bis(trifluoromethyl)bicyclo-[2,2,1]heptane-2,2-diacarbonitrile (BIDN). The I-V curve for I(GABA) displayed a unexpected biphasic aspect and was best fitted by two linear regressions giving two slope conductances of 35.6 +/- 2.1 and 80.9 +/- 4.1 nS for potentials ranging from 0 to -30 and -30 to -70 mV, respectively. At -50 mV, the current amplitude was decreased by cadmium chloride (CdCl2, 10(-3) M) and calcium-free solution. The semi-logarithmic curve for CdCl2-resistant I(GABA) gave a Hill coefficient of 2.4. Hyperpolarizing voltage step from -50 to -80 mV was known to increase calcium influx through calcium-resting channels. According to this protocol, a significant increase of I(GABA) amplitude was observed. However, this effect was never obtained when the same protocol was applied on cell body pretreated with CdCl2. When the calmodulin blocker N-(6-aminohexyl)-5-chloro-1-naphtalene-sulfonamide or the calcium-calmodulin-dependent protein kinase blocker 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) was added in the pipette solution, I(GABA) amplitude was decreased. Pressure ejection application of the cis-4-aminocrotonic acid (CACA) on DUM neuron cell body held at -50 mV, evoked a Cl- inward current which was insensitive to CdCl2. The Hill plot yielded a Hill coefficient of 2.3, and the I-V curve was always linear in the negative potential range with a slope conductance of 32.4 +/- 1.1 nS. These results, similar to those obtained with GABA in the presence of CdCl2 and KN-62, indicated that CACA activated one subtype of GABA receptor. Our study demonstrated that at least two distinct subtypes of Cl--dependent GABA receptors were expressed in DUM neurons, one of which is regulated by an intracellular Ca2+-dependent mechanism via a calcium-dependent protein kinase. The consequences of the modulatory action of Ca2+ in GABA receptors function and their sensitivity to insecticide are discussed. [less ▲]

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See detailKeratinocyte injury in drug-induced toxic epidermal necrolysis: Simultaneous but distinct topographic expression of CD95R and calprotectin.
Paquet, Philippe ULg; Pierard, Gérald ULg

in International Journal of Molecular Medicine (2002), 10(2), 145-7

Keratinocyte injury in drug-induced toxic epidermal necrolysis (TEN) is attributed to a dysregulation in the complex apoptotic machinery. This study was performed to investigate some aspects of the ... [more ▼]

Keratinocyte injury in drug-induced toxic epidermal necrolysis (TEN) is attributed to a dysregulation in the complex apoptotic machinery. This study was performed to investigate some aspects of the apoptotic pathomechanism involving calprotectin and the CD95 receptor (CD95R, FasR) in TEN. The expression of these two molecules corresponds to calcium-dependent and calcium-independent processes, respectively. Biopsies were collected from blistering skin in 21 TEN patients and from clinically uninvolved skin in 16 of these patients. Immunohistochemistry was performed using specific antibodies directed to CD95R and calprotectin. Half (8/16) of the biopsy specimens taken from clinically uninvolved sites showed the expression of calprotectin throughout the epidermis or restricted to the suprabasal layers. In these samples, a strong CD95R immunoreactivity was often restricted to the basal layer (8/16). Calprotectin was present in all biopsies of bullous skin, especially in suprabasal layers (15/21) or throughout the epidermis (6/21). By contrast, the prominent expression of CD95R was confined almost exclusively to the basal layer (15/21), and more rarely throughout the epidermis (2/21), and it remained sometimes unexpressed (4/21). A clear-cut boundary was often present between the areas labeled by the two antibodies with exceptional overlap between them. The simultaneous expression of calprotectin and CD95R in TEN at distinct levels of the epidermis indicates that the pathomechanism leading to keratinocyte death does not belong to a single process in TEN. Their expression in clinically uninvolved skin suggests that these processes are early and widespread events in TEN. [less ▲]

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See detailContribution à l'étude de la qualité bactériologique des eaux de surface à vocation touristique en Wallonie (Belgique)
Rosillon, Françis ULg; Culot, Marc ULg; Bosser, C. et al

in Cahiers de l'association scientifique européenne pour l'eau et la santé (2002), 7(1), 3-13

Au cours de la saison estivale 2000 et 2001, 33 zones récréatives en cours d'eau ont fait l'objet d'un suivi de la qualité bactériologique. Au-delà d'une simple surveillance, un profil de zone a été ... [more ▼]

Au cours de la saison estivale 2000 et 2001, 33 zones récréatives en cours d'eau ont fait l'objet d'un suivi de la qualité bactériologique. Au-delà d'une simple surveillance, un profil de zone a été établi. Celui-ci consiste à identifier et à hiérarchiser l'importance des sources de contamination fécale pouvant influencer la zone récréative. Lors d'événements pluvieux, une dégradation plus importante de la qualité des eaux a pu être mise en évidence. La diversité des sources de contamination implique une démarche multi-acteurs. A des actions ponctuelles de remédiation, s'ajoutent des mesures préventives d'accompagnement au sein de périmètres de protection. Une meilleure connaissance de la dynamique des germes fécaux dans le milieu naturel et du phénomène d'auto-épuration bactérienne devrait permettre de mieux définir les limites de ces périmètres de protection [less ▲]

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See detailCaractéristiques du système immunitaire du fœtus bovin et du veau nouveau-né. Implications dans la prévention et le diagnostic des infections d’origine virale
Thiry, Etienne ULg; Schynts, F.; Lemaire, Mylène

in Annales de Médecine Vétérinaire (2002), 146(4, AUG-SEP), 225-232

In this review the characteristics of the immune system of the bovine fetus and neonate are presented. These characteristics are important for the prevention and diagnosis of viral infections. Three ... [more ▼]

In this review the characteristics of the immune system of the bovine fetus and neonate are presented. These characteristics are important for the prevention and diagnosis of viral infections. Three examples are illustrated in this review : direct and indirect consequences of the infection of the fetus by the bovine viral diarrhea virus; guidelines for a prevention and diagnosis of this viral infection are given; the infection of the neonate by rotaviruses where colostral immunity has a key role in the prevention of the disease; the infection of the neonate by bovine herpesvirus 1 in the presence of colostral immunity which does not prevent latency and can lead to seronegative latent carriers after the disappearance of maternal antibodies. [less ▲]

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See detailElectronic structure of thallium filled skutterudites studied by x-ray absorption and Mossbauer spectroscopy
Long, G. J.; Mahieu, B.; Sales, B. C. et al

in Journal of Applied Physics (2002), 92(12), 7236-7241

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4 ... [more ▼]

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4-yFeySb12 and TlxCo4Sb12-zSnz compounds with a range of x, y, and z values. The thallium L-III-edge x-ray absorption spectra are independent of x, y, and z and are well reproduced by full multiple scattering calculations with a cluster with a radius of 8.5 Angstrom centered on thallium. The iron-57 Mossbauer spectra consist of two doublets and the major component is assigned to iron on the cobalt sublattice in view of its hyperfine parameters. The origin of the minor component is uncertain and is tentatively assigned to either iron with thallium vacancies as next nearest neighbors or to iron in the voids. The tin-119 Mossbauer spectral hyperfine parameters clearly indicate that tin substitutes for antimony in the skutterudite structure. Further, the tin electronic configuration is very similar to that of antimony and is insensitive to the thallium content. (C) 2002 American Institute of Physics. [less ▲]

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See detailResearch on Instruction in Physical Education. Review of the Research in Selected Roman Languages.
Piéron, Maurice ULg; Cloes, Marc ULg

in International Journal of Physical Education (2002), 39(1), 12-20

In French, the term "intervention" is used since a few years. The paper will: (1) deal with the topic of instruction limites to teachers' decisions and interventions during the interactive phase in ... [more ▼]

In French, the term "intervention" is used since a few years. The paper will: (1) deal with the topic of instruction limites to teachers' decisions and interventions during the interactive phase in teaching; during this phase, activities planned in the pre-interactive phase are implemented: the interactive phase concerns the task's presentation, the pupils' activity and the control of this activity in terms of behavioural management and of the quality of the eprformance (feedback); (2) refer to the main research methods used in gathering data, and (3) develop the main findings in the domain of instruction: teacher thinking and behaviour, pupils' thoughts and behaviour, management of the class or in other words control of pupils' behaviour. It is evident that thougts and behaviours are closely related and are part of the relationship between teachers and pupils. The paper focused only on texts appearing in French, Portuguese and Spanish published since 1997 in Physical eeducation journals and Proceeddings of international congresses. [less ▲]

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See detailLe médecin du travail face au harcèlement moral au travail : constats et prespectives
Gruslin, Isabelle ULg; Italiano, Patrick ULg; Faulx, Daniel ULg

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2002), 39(2), 61-68

L'article de D. Faulx et C. Geuzaine, paru dans le numéro 3-2000 de cette revue, aborde l'étendue du phénomène du harcèlement moral ainsi que les aspects juridiques de la définition, la description du ... [more ▼]

L'article de D. Faulx et C. Geuzaine, paru dans le numéro 3-2000 de cette revue, aborde l'étendue du phénomène du harcèlement moral ainsi que les aspects juridiques de la définition, la description du processus, ses conséquences médicales et les facteurs de risque. Dans la suite de cette étude, nous présentons ici les résultats d'une enquête menée auprès des médecins du travail, en tant que témoins et intervenants privilégiés dans le domaine du harcèlement. Cette enquête vise à apporter des informations descriptives originales concernant les attitudes, les opinions et représentations des médecins du travail par rapport au phénomène de harcèlement moral. En outre, elle est l'occasion de tester une série d'hypothèses sur les facteurs pouvant influencer l'attitude des médecins du travail vis-à-vis du harcèlement moral. [less ▲]

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See detailCharacterisation of aphid myrosinase and degradation studies of glucosinolates
Francis, Frédéric ULg; Lognay, Georges ULg; Wathelet, Jean-Paul ULg et al

in Archives of Insect Biochemistry and Physiology (2002), 50(4), 173-182

Myrosinase from Brevicoryne brassicae was purified by ammonium sulfate fractionation, dialysis, and chromatography on a DEAE column. The chromatography yielded a single peak and a 115.6-fold purification ... [more ▼]

Myrosinase from Brevicoryne brassicae was purified by ammonium sulfate fractionation, dialysis, and chromatography on a DEAE column. The chromatography yielded a single peak and a 115.6-fold purification. Further FPLC gel filtration gave a single peak at 120 kDa. Denaturing SDS/PAGE of the protein revealed a single band at 60 kDa, indicating that the native B. brassicae myrosinase is a dimer. Kinetic parameters towards 8 glucosinolates were calculated. Strong differences of V-max and Km were observed depending on the substrate. Degradation products of each glucosinolate were identified and quantified by GC-MS and GLC-FID, respectively. Using both crude aphid homogenates and purified myrosinase, two unique hydroxyglucosinolates, 3-butenyl- and benzyl-isothiocyanates were identified from progoitrin ((2S)-2-hydroxybut-3-enyl-glucosinolate) and sinalbin (4-hydroxybenzyl-glucosinolate) degradation respectively. Addition of ascorbic acid to the reaction mixtures containing sinalbin and progoitrin caused the production of hydroxyloted degradation products usually associated with plant myrosinase metabolisation. The occurrence of the myrosinase system in B. brassicae is discussed in terms of similar allelochemical adaptation between the herbivore and its host plant. (C) 2002 Wiley-Liss, Inc. [less ▲]

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See detailAortofemorographie par resonance magnetique nucleaire versus arteriographie conventionnelle: evaluation prospective.
NCHIMI LONGANG, Alain ULg; Brisbois, D.; Donkers, E. et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2002), 85(5), 246-51

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively ... [more ▼]

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively compared to DSA in 49 consecutive patients (40 males, 9 females; age range 38-80 years; mean age 64 years). According to Leriche and Fontaine's clinical gradation of lower limb ischemia, 5 patients were graded I, 37 graded II, 4 graded III, and 3 graded IV. Two observers graded stenoses for DSA and three for MRA. Cohen's kappa statistics were used to evaluate interobserver variability using MRA, as well as to compare MRA to DSA. In addition, sensitivity, specificity, positive and negative predictive values of MRA for the assessment of stenosis superior to 80% were calculated by using DSA as a gold standard, respectively for arterial trunks above and below the level of the knees. RESULTS: Overall accuracy of MRA was 92%. Comparison of DSA and MRA yielded a kappa value of 0.87 (0.95 for arterial trunks located above the level of the knees and 0.75 below). Interobserver agreement was very good. Sensitivity, specificity, positive and negative predictive values of MRA for the diagnosis of > 80% stenosis were respectively 98, 98, 85 and 99% above the level of the knees and 87, 91, 77 and 96% below the knees. CONCLUSION: MRA can be considered as valuable technique for the evaluation of peripheral arterial obstructive disease, especially for stenosis located above the level of the knees. [less ▲]

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See detailThe Belgian PCB/dioxin incident: analysis of the food chain contamination and health risk evaluation.
Bernard, Alfred; Broeckaert, Fabrice; De Poorter, Geert et al

in Environmental Research (2002), 88(1), 1-18

The Belgian PCB incident occurred at the end of January 1999 when a mixture of polychlorinated biphenyls (PCBs) contaminated with dioxins was accidentally added to a stock of recycled fat used in the ... [more ▼]

The Belgian PCB incident occurred at the end of January 1999 when a mixture of polychlorinated biphenyls (PCBs) contaminated with dioxins was accidentally added to a stock of recycled fat used in the production of animal feeds. Although signs of poultry poisoning were noticed by February, 1999, the source and the extent of the contamination were discovered only in May 1999, when it appeared that more than 2500 farms could have been supplied with contaminated feeds. This resulted in a major food crisis, which rapidly extended to the whole country and could be resolved only by the implementation of a large PCB/dioxin food monitoring program. Screening for PCB contamination was based on the determination of the seven PCB markers. When PCB concentrations exceeded the tolerance levels of 0.1 (milk), 0.2 (poultry, bovine, and pig meat), or 1 (animal feed) microg/g fat, dioxins (17 PCDD/Fs congeners) were also determined. At the end of December 1999, the database contained the results of more than 55,000 PCB and 500 dioxin analyses. The study of PCB levels and profiles in contaminated feeds delivered to poultry or pig farms confirmed that the Belgian PCB incident was due to a single source of PCB oil introduced into the food chain at the end of January 1999. This PCB oil had a congeners pattern closely matched to a mixture of Aroclor 1260/1254 in the proportion 75/25. The total amount of PCBs added to recycled fats was estimated at 50 kg (sum of the seven markers) or approximately 150 kg total PCBs, which corresponds to about 100 liters of PCB oil. This PCB mixture contained about 1g TEQ dioxins (more than 90- contributed by PCDFs) and about 2g TEQ dioxin-like PCBs. The proportions of PCB 52 and 101 congeners were fairly constant in animal feeds, excluding the possibility of secondary contamination due to fat recycling from contaminated animals. The highest concentrations of PCBs and dioxins were found in poultry and especially in the reproduction animals (hens and chicks), which showed the classical manifestations of chick edema disease. The pigs were also affected but to a lesser extent and no sign of intoxication was observed. The study of PCB/dioxin patterns and of the PCB:dioxin ratios revealed major differences in the metabolism of these compounds by farm animals. Whereas the PCBs:dioxins ratio was fairly constant in all poultry products with a mean value similar to that found in contaminated feeds (50,000), in pigs this ratio was both much higher and more variable (values up to 10,000,000), reflecting a faster elimination of dioxins than PCBs in these animals. These metabolic differences also emerged from the PCB and dioxin patterns which were altered much more in pigs than in poultry. Although the most contaminated food products (chicken meat) had PCB and dioxin levels more than 100 times above maximal recommended values, it is unlikely that this incident could have caused adverse effects in the general population of Belgium. A doubling of the PCB and dioxin burden of the young adult population would require the consumption of, respectively, 10 and 20 highly contaminated meals. In view of the very limited proportion of the poultry chain effectively contaminated during the incident (around 2%), such an extreme scenario was quite improbable for the general population except perhaps for farmers consuming their own products. But even in that case, it would have meant going back to the levels in the 1980s or attaining the body burden of subjects regularly eating contaminated seafood. [less ▲]

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See detailInfluence Of A New Axial Impeller On K(L)A And Xylanase Production By Penicillium Canescens 10-10c
Bakri, Yasser; Jacques, Philippe ULg; Shi, Kui et al

in Applied Biochemistry and Biotechnology (2002), 98

The effects of a new axial impeller (HTPG4) on oxygen volumetric transfer coefficient, KLa, and xylanase production by Penicillium canescens 10-10c were studied and compared for dual-impeller systems, one ... [more ▼]

The effects of a new axial impeller (HTPG4) on oxygen volumetric transfer coefficient, KLa, and xylanase production by Penicillium canescens 10-10c were studied and compared for dual-impeller systems, one with one DT4 impeller below and one HTPG4 above (DT4-HTPG4) and one with two DT4 (DT4-DT4) impellers, in a 5-L bioreactor. The volumetric coefficient of oxygen transfer was measured in culture medium using a gassing-out method at different gassing rates and agitation speeds. We observed that the DT4-HTPG4 combination provided better KLa performance than the DT4-DT4 combination. The two combinations were also tested for their influence on xylanase production by a filamentous microorganism; P. canescens 10-10c. These experiments demonstrated that the DT4-HTPG4 combination impeller enhanced enzyme production up to 23% compared with the DT4-DT4 combination at an aeration rate of 1 vvm and an agitation speed of 600 rpm. The main cause for this difference is thought to be a higher shear stress generated by the DT4-DT4 combination, which damages the mycelium of P. canescens and decreases xylanase production. [less ▲]

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See detailDelays in claiming social security benefits
Jousten, Alain ULg; Diamond, P.; Coile, C. et al

in Journal of Public Economics (2002), 84

This paper focuses on Social Security benefit claiming behavior, a take-up decision that has been ignored in the previous literature. Using financial calculations and simulations based on an expected ... [more ▼]

This paper focuses on Social Security benefit claiming behavior, a take-up decision that has been ignored in the previous literature. Using financial calculations and simulations based on an expected utility maximization model, we show that delaying benefit claim for a period of time after retirement is optimal in a wide variety of cases and that gains from delay may be significant.We find that approximately 10% of men retiring before their 62nd birthday delay claiming for at least 1 year after eligibility. We estimate hazard and probit models using data from the New Beneficiary Data System to test four cross-sectional predictions. While the data suggest that too few men delay, we find that the pattern of delays by early retirees is generally consistent with the hypotheses generated by our theoretical model. [less ▲]

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See detail- La bande dessinée muette et le texte
Paques, Frédéric ULg

in Art&Fact (2002), 21

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See detailIntranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs.
Zonderland, Jean-Luc; Stork, Christoph; Saunders, Jimmy et al

in Journal of the American Veterinary Medical Association [=JAVMA] (2002), 221

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See detailThe potential of the beta-Microprobe, an intracerebral radiosensitive probe, to monitor the [(18)F]MPPF binding in the rat dorsal raphe nucleus.
Zimmer, L.; Pain, F.; Mauger, G. et al

in European Journal of Nuclear Medicine and Molecular Imaging (2002), 29(9), 1237-47

The aim of this study was to demonstrate the ability of a recently developed beta(+)-range sensitive intracerebral probe (beta-Microprobe) to measure the binding kinetics of [(18)F]MPPF, a well-documented ... [more ▼]

The aim of this study was to demonstrate the ability of a recently developed beta(+)-range sensitive intracerebral probe (beta-Microprobe) to measure the binding kinetics of [(18)F]MPPF, a well-documented 5-HT(1A) serotoninergic receptor ligand, in the dorsal raphe nucleus (DRN) of the anaesthetised rat. This midbrain nucleus presents a high concentration of 5-HT(1A) receptors known to be implicated in the effects of antidepressants. The difficulty confronting this study lay in the fact that the dimensions of the DRN are smaller than the detection volume of the beta-Microprobe. In the first part of the study, we studied the feasibility of this measurement from a theoretical point of view by autoradiography and a Monte Carlo simulation. We determined the optimal beta-Microprobe location close to the DRN and verified that this configuration allowed accurate determination of [(18)F]MPPF specific binding in the nucleus. In the second part of our study, we measured the in vivo time-concentration curves of [(18)F]MPPF binding in the DRN in comparison with the cerebellum. The specificity of [(18)F]MPPF binding in the DRN was confirmed by its displacement after non-labelled 5-HT(1A)antagonist injection (MPPF or WAY-100635). Moreover, we verified the feasibility of using beta-Microprobe monitoring and simultaneous validation by microdialysis to study the effect of an increase in extracellular serotonin, induced by fenfluramine injection, on [(18)F]MPPF binding in the DRN. Our theoretical simulations, confirmed by our experimental results, demonstrate the ability of this new device to monitor in vivo the binding of [(18)F]MPPF in the DRN of anaesthetised rodents. [less ▲]

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See detailPrimary Structure of Selected Archaeal Mesophilic and Extremely Thermophilic Outer Surface Layer Proteins
Claus, Harald; Akça, Erol; Debaerdemaeker, Tony et al

in Systematic & Applied Microbiology (2002), 25

The archaea are recognized as a separate third domain of life together with the bacteria and eucarya. The archaea include the methanogens, extreme halophiles, thermoplasmas, sulfate reducers and sulfur ... [more ▼]

The archaea are recognized as a separate third domain of life together with the bacteria and eucarya. The archaea include the methanogens, extreme halophiles, thermoplasmas, sulfate reducers and sulfur metabolizing thermophiles, which thrive in different habitats such as anaerobic niches, salt lakes, and marine hydrothermals systems and continental solfataras. Many of these habitats represent extreme environments in respect to temperature, osmotic pressure and pH-values and remind on the conditions of the early earth. The cell envelope structures were one of the first biochemical characteristics of archaea studied in detail. The most common archaeal cell envelope is composed of a single crystalline protein or glycoprotein surface layer (S-layer), which is associated with the outside of the cytoplasmic membrane. The S-layers are directly exposed to the extreme environment and can not be stabilized by cellular components. Therefore, from comparative studies of mesophilic and extremely thermophilic S-layer proteins hints can be obtained about the molecular mechanisms of protein stabilization at high temperatures. First crystallization experiments of surface layer proteins under microgravity conditions were successful. Here, we report on the biochemical features of selected mesophilic and extremely archaeal S-layer (glyco-) proteins. [less ▲]

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See detailEvaluation of ocean model ventilation with CFC-11: comparison of 13 global ocean models
Dutay, J.-C.; Bullister, J. L.; Doney, S. C. et al

in Ocean Modelling (2002), 4(2), 89-120

We compared the 13 models participating in the Ocean Carbon Model Intercomparison Project (OCMIP) with regards to their skill in matching observed distributions of CFC-11. This analysis characterizes the ... [more ▼]

We compared the 13 models participating in the Ocean Carbon Model Intercomparison Project (OCMIP) with regards to their skill in matching observed distributions of CFC-11. This analysis characterizes the abilities of these models to ventilate the ocean on timescales relevant for anthropogenic CO2 uptake. We found a large range in the modeled global inventory (+/- 30\%), mainly due to differences in ventilation from the high latitudes. In the Southern Ocean, models differ particularly in the longitudinal distribution of the CFC uptake in the intermediate water, whereas the latitudinal distribution is mainly controlled by the subgrid-scale parameterization. Models with isopycnal diffusion and eddy-induced velocity parameterization produce more realistic intermediate water ventilation. Deep and bottom water ventilation also varies substantially between the models. Models coupled to a sea-ice model systematically provide more realistic AABW formation source region; however these same models also largely overestimate AABW ventilation if no specific parameterization of brine rejection during sea-ice formation is included. In the North Pacific Ocean, all models exhibit a systematic large underestimation of the CFC uptake in the thermocline of the subtropical gyre, while no systematic difference toward the observations is found in the subpolar gyre. In the North Atlantic Ocean, the CFC uptake is globally underestimated in subsurface. In the deep ocean, all but the adjoint model, failed to produce the two recently ventilated branches observed in the North Atlantic Deep Water (NADW). Furthermore, simulated transport in the Deep Western Boundary Current (DWBC) is too sluggish in all but the isopycnal model, where it is too rapid. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailRisk factors for hepatitis C: past, present and future
Delwaide, Jean ULg; Bourgeois, N.; Colle, I. et al

in Acta Gastro-Enterologica Belgica (2002), 65(2), 87-89

Patients at risk for hepatitis C (HCV) are those exposed to a major risk factor (i.e. blood transfusion prior 1990, and intravenous drug abuse), and those exposed to a minor risk factor (sexual, mother-to ... [more ▼]

Patients at risk for hepatitis C (HCV) are those exposed to a major risk factor (i.e. blood transfusion prior 1990, and intravenous drug abuse), and those exposed to a minor risk factor (sexual, mother-to-infant transmission, household contact, nosocomial contamination). The present paper aims to review the current and past modes of transmission of the virus C. [less ▲]

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See detailInfluence of the metal electronic properties on the sum-frequency generation spectra of dodecanethiol self-assembled monolayers on Pt (111), Ag (111) and Au (111) single crystals
Dreesen, Laurent ULg; Humbert, Christophe; Celebi, M. et al

in Applied Physics B : Lasers & Optics (2002), 74

Infrared-visible sum-frequency generation (SFG) spectroscopy is performed at different visible wavelengths between 450 and 650 nm in order to investigate the interaction between metallic substrates (Pt ... [more ▼]

Infrared-visible sum-frequency generation (SFG) spectroscopy is performed at different visible wavelengths between 450 and 650 nm in order to investigate the interaction between metallic substrates (Pt, Ag and Au) and 1-dodecanethiol self-assembled monolayers. We show that such measurements provide a means to study the electronic properties of metals as well as the interference phenomena between the SFG signals from the adsorbate and the substrate. The common features of the three interfaces are the vibration modes of the terminal methyl groups. However, these resonances appear as peaks for Pt (111) and as dips in the case of Ag (111). Their shape is not modified when the visible wavelength is tuned between 450 and 650 nm. Moreover, the metal sum-frequency generation contribution is slightly modified in that spectral range. For Au (111) samples, the sum-frequency generation spectrum drastically evolves with the visible wavelength: the peak resonant sum-frequency generation signal at 450 nm becomes rather dip-shaped at 650 nm. The non-linear response of gold is also enhanced when the wavelength associated with the sum-frequency process is close to 480 nm. These results are interpreted on the basis of the metal electronic properties that are responsible for the non-resonant contribution to the SFG signal. [less ▲]

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See detailLe roman poétique en 1929. Nord, entre fantastique réel et réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 31-40

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See detailEuclidean and fractal computer-assisted corneofungimetry: a comparison of 2% ketoconazole and 1% terbinafine topical formulations.
Arrese Estrada, Jorge ULg; Fogouang, L.; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(3), 222-7

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups ... [more ▼]

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups of 15 volunteers, corneofungimetry was used to compare the effect of 5-day b.i.d. treatments with 2% ketoconazole and 1% terbinafine creams. METHODS: The bioassay was performed using 10 isolates of each of the 3 fungi Trichophyton rubrum, T. mentagrophytes var. interdigitale and Candida albicans put to grow on human stratum corneum. Controls were stratum corneum either untreated or enriched in propylene glycol contained in an unmedicated vehicle. Quantitative assessments were made using both Euclidean and fractal geometry parameters. RESULTS: In comparison with untreated stratum corneum, the fungitoxic activity of the 2% ketoconazole and 1% terbinafine formulations was obvious and similar against dermatophytes. By contrast, 2% ketoconazole was significantly more active against C. albicans than 1% terbinafine. The propylene-glycol-containing vehicle did not exhibit a significant effect upon the dermatophyte growth. Positive linear correlations were yielded between the extent area and the fractal dimension D of dermatophyte mycelia. By contrast, D appeared unrelated to the relative area of dermatophyte growth compared to controls. CONCLUSION: The combination of Euclidean and fractal analyses improves the information provided by the corneofungimetry bioassay. Creams containing 2% ketoconazole and 1% terbinafine appear equally effective against dermatophytes while the former is more potent against Candida albicans. [less ▲]

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See detailDetermination of affinity, stoichiometry and sequence selectivity of minor groove binder complexes with double-stranded oligodeoxynucleotides by electrospray ionization mass spectrometry
Rosu, Frédéric ULg; Gabelica, Valérie ULg; Houssier, Claude ULg et al

in Nucleic Acids Research (2002), 30(16), 82

Electrospray mass spectrometry was evaluated regarding the reliability of the determination of the stoichiometries and equilibrium association constants from single spectra. Complexes between minor groove ... [more ▼]

Electrospray mass spectrometry was evaluated regarding the reliability of the determination of the stoichiometries and equilibrium association constants from single spectra. Complexes between minor groove binders (Hoechst 33258, Hoechst 33342, DAPI, netropsin and berenil) and 12mer oligonucleotide duplexes with a central sequence (A/T)(4) flanked by G/C base pairs were chosen as model systems. To validate the electrospray ionization mass spectrometry (ESI-MS) method, comparisons were made with circular dichroism and fluorescence spectroscopy measurements. ESI-MS allowed the detection of minor (2 drug + DNA) species for Hoechst 33258, Hoechst 33342, DAPI and berenil with duplex d(GGGG(A/T)(4)GGGG). d(CCCC(A/T)(4)CCCC), which were undetectable with the other techniques. Assuming that the duplexes and the complexes have the same electrospray response factors, the equilbrium association constants of the 1:1 and 2:1 complexes were determined by ESI-MS, and the values show a good quantitative agreement with fluorescence determined constants for Hoechst 33258 and Hoechst 33342. It is also shown that ESI-MS can quickly give reliable information on the A/T sequence selectivity of a drug: the signal of a complex is directly related to the affinity of the drug for that particular duplex. The potential of ESI-MS as a qualitative and quantitative affinity screening method is emphasized. [less ▲]

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See detailEffect of instillation into lung of autologous blood on pulmonary function and tracheobronchial wash cytology
Art, Tatiana ULg; Tack, S.; Kirschvink, Nathalie et al

in Equine Veterinary Journal. Supplement (2002), 34

This study aimed at measuring the functional consequences and the pulmonary cytology changes following a simulation of pulmonary haemorrhage. Pulmonary function tests including lobeline-induced ... [more ▼]

This study aimed at measuring the functional consequences and the pulmonary cytology changes following a simulation of pulmonary haemorrhage. Pulmonary function tests including lobeline-induced hyperventilation, cytology of tracheo-bronchial wash (TBW) and thoracic radiographs were performed before, as well as 1, 7, 14 and 28 days after, the instillation of 300 ml of blood into the lungs of 4 horses deemed free of exercise-induced pulmonary haemorrhage (Group 1). Control data (Group 2) were obtained by instilling the same volume of saline into the lungs of the same horses in a crossover design (control). The instillation of blood or saline resulted in an increase in the number of neutrophils in the TBW. Thoracic radiographs showed increased opacity in the caudodorsal region of the lungs in 4/4 (Day 1) and 2/4 horses (Day 7), in Group 1, and in 2/4 (Day 1) and 0/4 horses (Day 7) in the control group. These changes were attributed to the instillation procedure rather than the nature of the instilled material. Breathing mechanics and arterial blood gases at rest were not affected in either Groups 1 or 2. However, the maximal expiratory peak flow recorded during lobeline-induced hyperventilation was significantly lower (P<0.05) and the total pulmonary resistance significantly higher (P<0.05) on Day 1 in Group 1, but not Group 2. These observations suggest that expiratory flows might be partly limited in bleeders when breathing at high airflow [less ▲]

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See detailResults of a whole genome scan targeting QTL for growth and carcass traits in a Pietrain x Large White intercross
Nezer, C.; Moreau, L.; Wagenaar, D. et al

in Genetics, Selection, Evolution (2002), 34(3, May-Jun), 371-387

We herein report the results of a whole genome scan performed in a Pietrain x Large White intercross counting 525 offspring to map QTL influencing economically important growth and carcass traits. We ... [more ▼]

We herein report the results of a whole genome scan performed in a Pietrain x Large White intercross counting 525 offspring to map QTL influencing economically important growth and carcass traits. We report experiment-wide significant lod scores (> 4.6) for meatiness and fat deposition on chromosome SSC2, and for average daily gain and carcass length on chromosome SSC7. Additional suggestive lod scores (> 3.3) for fat deposition are reported on chromosomes SSC1, SSC7 and SSC13. A significant dominance deviation was found for the QTL on SSC1, while the hypothesis of an additive QTL could not be rejected for the QTL on SSC7 and SSC13. No evidence for imprinted QTL could be found for QTL other than the one previously reported on SSC2. [less ▲]

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See detailLa peau et son horloge chronobiologique au quotidien.
Henry, Frédérique ULg; Arrese Estrada, Jorge ULg; Claessens, N. et al

in Revue Médicale de Liège (2002), 57(10), 661-5

Some cutaneous functions of importance are governed by periodical variations according to the nycthemeral timing. Similarly to other organs, the skin is under the influence of a coherent organisation of ... [more ▼]

Some cutaneous functions of importance are governed by periodical variations according to the nycthemeral timing. Similarly to other organs, the skin is under the influence of a coherent organisation of circadian and nythemeral rhythms modulating various biological cycles which usually display a wide amplitude. The cutaneous biorhythms in humans suggest that during daylight the skin boosts diverse protective functions with regard to environmental threats. In the evening and at night, the skin increases its renewal and diverse metabolic processes. Biorhythms in the skin which are in line with the organism's needs, merit to be recognized. Chronophysiology, chronopathology and clinical chronopharmacology may help reach optimal therapeutic decisions. [less ▲]

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See detailEcology of Salmonella in slaughter pigs digestive tract and study of the contamination of carcasses
Boudry, Christelle ULg; Korsak Koulagenko, Nicolas ULg; Jacob, Benoit et al

in Annales de Médecine Vétérinaire (2002), 146(6, DEC-JAN), 353-360

This article presents a study on the Salmonella asymptomatic carriage of finishing pigs and its consequences on the contamination of carcasses. Twenty finishing pigs were followed to determine the faecal ... [more ▼]

This article presents a study on the Salmonella asymptomatic carriage of finishing pigs and its consequences on the contamination of carcasses. Twenty finishing pigs were followed to determine the faecal shedding of Salmonella. No sample was positive but at the slaughterhouse, the analysis of tonsils and certain parts of the digestive tract (mesenterial lymph nodes, ileum and large intestine content) revealed that 70% of the pigs were positive. The strains isolated from the faecal samples of the large intestine and from tonsils were identical, which might indicate that there has been an oral contamination from pig to pig due to the shedding of Salmonella or a carriage of different strains in different organs. The mesenterial lymph nodes (40 % positive) were contaminated by strains which were different from those from the faecal samples and tonsils. Salmonella strains were only found on the swabs of one carcass. A complementary assay has shown the negative role played by the scalding step. This latter may contaminate the oral and rectal cavities of slaughtered animals. This entire study reveals the difficulty to predict the contamination risk at the slaughterhouse from the analysis of finishing pigs faecal samples. Therefore, a better knowledge of the carriage and the shedding of Salmonella during the finishing period and during the slaughter is necessary to minimise meat contamination. [less ▲]

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See detailPlacental GH, IGF-I, IGF-binding protein-1 and leptin during a glucose challenge test in pregnant women : relation with maternal body weight, glucose tolerance, and birth weight
Verhaeghe, J.; Pintiaux, Axelle ULg; Van Herck, E. et al

in Journal of Clinical Endocrinology and Metabolism (2002), 87(6), 2875-2882

The prediction of birth weight may be improved by the measurement of hormones or growth factors in the mother. We measured body weight (BW) and plasma levels of placental GH (PGH), IGF-I, IGF-binding ... [more ▼]

The prediction of birth weight may be improved by the measurement of hormones or growth factors in the mother. We measured body weight (BW) and plasma levels of placental GH (PGH), IGF-I, IGF-binding protein-1 (IGFBP-1), and leptin at the time of the glucose challenge test (GCT) in 289 women, who were pregnant with a single fetus, between 24 and 29 wk gestational age (GA). Delivery occurred 12 +/- 2 (mean +/- SD) wk later. First, we examined which variables regulate these hormonal factors. Multiple regression showed that PGH concentrations were determined by GA at sampling and were negatively related to BW. IGF-I levels were mainly determined by PGH, and also by insulin, BW, and (negatively) age. IGFBP-1 concentrations were negatively determined by BW, insulin, and IGF-I. BW was also a powerful determinant of leptin levels, with insulin as a less robust determinant. Second, we examined the relation to glucose levels. PGH, IGF-I, and IGFBP-1 concentrations were not correlated with post-GCT glucose levels and were comparable in women with a normal or disturbed GCT (glucose >/=7.8 mmol/liter; n = 72). Finally, we examined the relation with birth weight and placental weight. Birth weight, corrected for GA and stratified into percentile groups, and the ponderal index at birth were strongly related to maternal BW, but not to maternal PGH, IGF-I, or IGFBP-1 levels. Neither was maternal leptin related to birth weight, but leptin concentrations were slightly higher in women who delivered obese babies. Placental weight was not related to any of the hormonal factors. This prospective study indicates that the variation in circulating PGH, IGF-I, IGFBP-1, and leptin between 24 and 29 wk of pregnancy is strongly dependent on maternal BW, but is unrelated to glucose tolerance. In addition, the measurement of PGH, IGF-I, IGFBP-1, or leptin at the time of the GCT is not useful clinically to predict birth weight. [less ▲]

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See detailNormative and psychometric data from the Body Image Assessment - Revised in a population of french-speaking women
Bragard, Isabelle ULg; Mayers, I.; Demoulin, Catherine et al

in Psychologica Belgica (2002), 42(4), 227-249

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female ... [more ▼]

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female subjects. They completed questionnaires assessing body experience, eating pathology, psychological functioning, general perception and the BIA-R (Beebe et al., 1999). This test consists of nine silhouettes from which the subject has to choose the somatotype corresponding to her actual shape (cognitive response), the way she feels (affective response) and the way she would like to look (optative response). The results show a good concurrent validity for the cognitive and affective indices and the affective/ cognitive vs. optative divergences. On the other hand, we were not able to demonstrate such validity for the optative index and the affective vs. cognitive divergence index [less ▲]

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See detailDes pratiques aux performances : la littératie chez les jeunes de 15 ans
Lafontaine, Dominique ULg

in Lettre de la DFLM (La) (2002), 30

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See detailDifferential expression of two somatostatin genes during zebrafish embryonic development
Devos, Nathalie; Deflorian, Gianluca; Biemar, Frédéric et al

in Mechanisms of Development (2002), 115(1-2), 133-7

We have identified the cDNAs of two new zebrafish preprosomatostatins, PPSS1 and PPSS3, in addition to the previously cloned PPSS2 (Argenton et al., 1999). PPSS1 is the orthologue of mammalian PPSSs, with ... [more ▼]

We have identified the cDNAs of two new zebrafish preprosomatostatins, PPSS1 and PPSS3, in addition to the previously cloned PPSS2 (Argenton et al., 1999). PPSS1 is the orthologue of mammalian PPSSs, with a conserved C-terminal SS-14 sequence, PPSS2 is a divergent SS precursor and PPSS3 is a cortistatin-like prohormone. Using whole-mount in situ hybridisation, we have analysed the expression of PPSS1 and PPSS2 in zebrafish embryos up to 5 days post fertilisation. PPSS1 was expressed in the developing pancreas and central nervous system (CNS), whereas PPSS2 expression was exclusively pancreatic. In the CNS, PPSS1 was detected in several areas, in particular in the vagal motor nucleus and in cells that pioneer the tract of the postoptic commissure. PPSS1 was also expressed transiently in the telencephalon and spinal motor neurons. In all areas but the telencephalon PPSS1 was coexpressed with islet-1. [less ▲]

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See detailRadiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.
Egger, J-F; Coindre, J-M; Benhattar, J et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2002), 15(9), 998-1004

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant ... [more ▼]

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004 [less ▲]

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See detailThe effect of pH on the alternative oxidase activity in isolated Acanthamoeba castellanii mitochondria.
Jarmuszkiewicz, W.; Hryniewiecka, L.; Sluse, Francis ULg

in Journal of Bioenergetics & Biomembranes (2002), 34(3), 221-226

Mitochondria of Acanthamoeba castellanii possess a cyanide-resistant GMP-stimulated ubiquinol alternative oxidase in addition to the cytochrome pathway. In a previous work it has been observed that an ... [more ▼]

Mitochondria of Acanthamoeba castellanii possess a cyanide-resistant GMP-stimulated ubiquinol alternative oxidase in addition to the cytochrome pathway. In a previous work it has been observed that an interaction between the two ubiquinol-oxidizing pathways exists in intact A. castellanii mitochondria and that this interaction may be due to a high sensitivity of the alternative oxidase to matrix pH. In this study we have shown that the alternative oxidase activity reveals a pH-dependence with a pH optimum at 6.8 whatever the reducing substrate may be. The GMP stimulation of alternative oxidase is also strongly dependent on pH implicating probably protonation/deprotonation processes at the level of ligand and protein with an optimum pH at 6.8. The ubiquinone redox state-dependence of alternative oxidase activity is modified by pH in such a way that the highest activity for a given ubiquinone redox state is observed at pH 6.8. Thus pH, binding of GMP, and redox state of ubiquinone collaborate to set the activity of the GMP-stimulated alternative oxidase in isolated A. castellanii mitochondria. The high pH sensitivity of the alternative oxidase could link inactivation of the cytochrome pathway proton pumps to activation of the alternative oxidase with acceleration of redox free energy dissipation as a consequence. [less ▲]

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See detailLa gestion des eaux par bassins hydrographiques
Pâques, Michel ULg; Leprince, Sylviane ULg

in Aménagement - Environnement (2002)

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See detailDe Mably à Marin. Dans le dédale ornemental de l'imprimeur parisien Quillau (XVIIIe siècle)
Droixhe, Daniel ULg

in Livre et l'Estampe (Le) (2002), 48(158), 43-69

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See detailModulation par le cycle cellulaire de l'implantation des cellules souches hématopoïétiques
Gothot, André ULg; Giet, Olivier ULg; Huygen, S. et al

in Hématologie (2002), 8

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See detailDust variability and land degradation in the Sahel
Ozer, Pierre ULg

in Belgeo (2002), 2002(2), 195-209

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See detailLe traitement de la phraséologie dans DEFI
Michiels, Archibal ULg

in Linguistica Antverpiensia (2002)

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See detailModélisation de l’impact de mollusques filtreurs sur le phytoplancton de la Moselle.
Descy, Jean-Pierre; Everbecq, Etienne ULg; Gosselain, Véronique ULg et al

in Tribune de l'Eau (La) (2002), 55-56(n° 619-620), 130-138

Le modèle POTAMON (Everbecq & al., 2001) a été utilisé pour simuler l'effet de mollusques bivalves (principalement Dreissena polymorpha) sur le phytoplancton et le zooplancton d'une rivière de plaine, la ... [more ▼]

Le modèle POTAMON (Everbecq & al., 2001) a été utilisé pour simuler l'effet de mollusques bivalves (principalement Dreissena polymorpha) sur le phytoplancton et le zooplancton d'une rivière de plaine, la Moselle. Les simulations suggèrent un impact significatif des mollusques filtreurs sur le phytoplancton, en particulier en été. Les simulations ont également permis d'établir un bilan carbone de la rivière et d'expliquer les déficits en oxygène observés dans la Moselle. [less ▲]

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See detailExplorer les secrets du patrimoine cheveux.
Franchimont, Claudine ULg; Pierard, Gérald ULg

in Skin (2002), 5

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See detailDoes sulfide detoxication occur in the gills of the hydrothermal vent shrimp, Rimicaris exoculata?
Compère, Philippe ULg; Martinez, Anne-Sophie; Charmantier-Daures, Mireille et al

in Comptes Rendus Biologies (2002), 325

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See detailRadiative transfer based scaling of LAI/FPAR retrievals from reflectance data of different resolutions.
Tian, Y; Wang, Y; Zhang, Y et al

in Remote Sensing of Environment (2002), 84(1), 143-159

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See detailComputed tomographic findings in 35 dogs with nasal aspergillosis
Saunders, J. H.; Zonderland, J. L.; Clercx, Cécile ULg et al

in Veterinary Radiology & Ultrasound (2002), 43(1, JAN-FEB), 5-9

The purpose of this study was to describe the computed tomographic (CT) features of nasal aspergillosis in dogs. Initial (n = 35) and follow-up (n = 12) CT images were available from 35 dogs. The most ... [more ▼]

The purpose of this study was to describe the computed tomographic (CT) features of nasal aspergillosis in dogs. Initial (n = 35) and follow-up (n = 12) CT images were available from 35 dogs. The most commonly encountered CT findings were (1) moderate to severe cavitary destruction of the turbinates with presence of a variable amount of abnormal soft tissue in the nasal passages, (2) non-specific thickening of the mucosa adjacent to the inner surface of bones of the frontal sinus, maxillary recess and nasal cavity and, (3) thickened reactive bone. The findings were consistent with a disease initially affecting one nasal cavity then progressing into the ipsilateral frontal sinus, the contralateral nasal cavity and the contralateral frontal sinus. Two dogs with associated nasal foreign body had a more localized invasion of the nasal cavity. Attenuation values and contrast enhancement were not specific. With follow-up examinations, a reduction in the amount of abnormal soft tissue was observed in all dogs except one, but this reduction could not be quantified. [less ▲]

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See detailNudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
Franchimont, Claudine ULg; Goffin, Véronique ULg; Henry, Frédérique ULg et al

in International Journal of Cosmetic Science (2002), 24(5), 249-56

Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic ... [more ▼]

Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, mug cm(-2) h(-1)) was also measured using a Sebumeter((R)). The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface. [less ▲]

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See detailAutorité parentale et actes médicaux
Leleu, Yves-Henri ULg; Delval, S.

in Journal du Droit des Jeunes (2002)

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See detailAnalyse de l'impact physiologique et economique de l'elagage des arbres d'alignement en port libre.
Toussaint, André ULg; Kervyn de Meerendre, V.; Delcroix, B. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(2), 99-107

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See detailRate coefficient determination in charge transfer reactions
Vaeck, Nathalie; Baloïtcha, Ezinvy; Desouter, Michèle ULg et al

in International Journal of Molecular Sciences (2002), 3

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See detailPhytoremediation to increase the degradation of PCBS and PCDD/Fs
Campanella, Bruno ULg; Bock, Claudia; Schröder, Peter

in Environmental Science and Pollution Research (2002), 9

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See detailAutomatic time stepping algorithms for implicit numerical simulations of non-linear dynamics
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Advances in Engineering Software (2002), 33(7-10, JUL-OCT), 589-603

When an implicit integration scheme is used, variable step strategies are especially well suited to deal with problems characterized by high non-linearities. Constant step size strategies generally lead ... [more ▼]

When an implicit integration scheme is used, variable step strategies are especially well suited to deal with problems characterized by high non-linearities. Constant step size strategies generally lead to divergence or extremely costly computations. An automatic time stepping algorithm is proposed that is based on estimators of the integration error of the differential dynamic balance equations. Additionally, the proposed algorithm automatically takes decisions regarding the necessity of updating the tangent matrix or stopping the iterations, further reducing the computational cost. As an illustration of the capabilities of this algorithm, several numerical simulations of both academic and industrial problems are presented. (C) 2002 Civil-Comp Ltd and Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailLa dignité humaine comme concept juridique
Fierens, Jacques ULg

in Journal des Tribunaux (2002)

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See detailPour une sémiologie historique de l'acte photographique
Havelange, Carl ULg

in Revue de la Faculté des Lettres d'El Jadida (2002)

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See detailDifferential pathomechanisms of epidermal necrolytic blistering diseases.
Paquet, Philippe ULg; Pierard, Gérald ULg

in International Journal of Molecular Medicine (2002), 10(6), 695-9

Staphylococcal scalded skin syndrome (SSSS) results from the effect of exfoliative-toxins produced by staphylococcal strains. The disease affects predominantly children, and is rare in adults. We report ... [more ▼]

Staphylococcal scalded skin syndrome (SSSS) results from the effect of exfoliative-toxins produced by staphylococcal strains. The disease affects predominantly children, and is rare in adults. We report two cases of the adult type of SSSS. Corticotherapy, chronic alcohol abuse and epilepsy-related immune changes might have been predisposing factors in these patients. The immunopathological characteristics of the inflammatory cell infiltrate in adults SSSS have not been thoroughly explored so far in the literature. Biopsies from 2 patients with bullous SSSS skin were studied by means of immunochemistry using a panel of 10 antibodies directed to FXIIIa, CD15, CD31, CD45R0, CD50, CD54, CD62E, CD95, CD106, and L1-protein, respectively. Cutaneous biopsies from related blistering diseases were compared. They included drug-induced toxic epidermal necrolysis (TEN), bullous impetigo and superficial pemphigus. A dense cell infiltrate composed of granulocytes (CD15+), macrophages (L1 protein+) and memory T cells (CD45R0+) and a strong expression of ICAM-3 (CD50) were present in the epidermis. CD95+ keratinocytes were lining the intraepidermal blisters. Type I dermal dendrocytes (Factor XIIIa+) were numerous and plump in the dermis. Bullous impetigo exhibited the same pattern of inflammatory cells, but with a lower density in type I dermal dendrocytes. TEN differed from SSSS by both the absence of CD15+ granulocytes and a stronger expression of the pro-apoptotic CD95 antigen in the epidermis. In superficial pemphigus, CD95 antigen was not expressed, and CD15+ granulocytes, CD45R0+ lymphocytes and L1 protein+ monocytes were much less numerous. It is concluded that the specific binding of SSSS-induced exotoxins to the desmosomes alters the keratinocyte metabolism leading to an inflammatory reaction followed by focal apoptosis. Our findings are in line with the concept that SSSS exotoxins might be superantigens. A common pathomechanism leading to epidermal destruction is likely operative in SSSS and bullous impetigo. The inflammatory cell composition in TEN and superficial pemphigus markedly differs from that in SSSS. [less ▲]

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See detailReplicon typing of the F18 fimbriae encoding plasmids of enterotoxigenic and verotoxigenic Escherichia coli strains from porcine postweaning diarrhoea and oedema disease
Fekete, PZs; Gérardin, J.; Jacquemin, E. et al

in Veterinary Microbiology (2002), 85

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See detailAsymmetrical international attitudes
Van Oudenhoven, J.; Askevis-Leherpeux, F.; Hannover, B. et al

in European Journal of Social Psychology (2002), 32(2), 275-289

In general, attitudes towards nations have a fair amount of reciprocity: nations either like each other are relatively indifferent to each other or dislike each other Sometimes, however international ... [more ▼]

In general, attitudes towards nations have a fair amount of reciprocity: nations either like each other are relatively indifferent to each other or dislike each other Sometimes, however international attitudes are asymmetrical. In this study, we use social identity theory in order to explain asymmetrical attitudes. Parting from social identity theory, asymmetrical attitudes can be predicted to occur most likely between countries that are linguistically either similar or closely related, but differ in size. Europe, more than any other continent, offers a rich variety of nations which represent natural conditions for our study, such as size and degree of linguistic similarity. In order to test hypotheses derived from social identity theory, we asked respondents (N = 405) from (Dutch- and French-speaking) Belgium, France, Germany, and The Netherlands to fill out a questionnaire on three large nations (Germany, Great Britain, France) and three smaller ones (The Netherlands, Belgium, and Denmark). Results strongly supported hypotheses and confirm that a social identity approach may help to better understand international attitudes. [less ▲]

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See detailPredicting transpiration from forest stands in Belgium for the 21st century
Misson, Laurent; Rasse, Daniel; Vincke, Caroline et al

in Agricultural and Forest Meteorology (2002), 111(4), 265-282

Canopy transpiration is a major element of the hydrological cycle of temperate forests. Levels of water stress during the 21st century will be largely controlled by the response of canopy transpiration to ... [more ▼]

Canopy transpiration is a major element of the hydrological cycle of temperate forests. Levels of water stress during the 21st century will be largely controlled by the response of canopy transpiration to changing environmental conditions. One year of transpiration measurement in two stands (Quercus robur L. and Fagus sylvatica L.) was used to calibrate the ASPECTS model on a(1) and D-0, two parameters of a modified version of Leuning's equation of stomatal conductance. A second year of data was used to validate the model. The results indicate a higher sensitivity of g(sc), to vapour pressure deficit (DS) in oak than in beech (D-0 (oak) < D-0 (beech)). To simulate future forest transpiration, site specific weather data sets were constructed from GCM outputs, spatially and temporally downscaled with local climatic data. Temperature increase between the end of the 20th and 21st centuries was predicted to be 2.8 degreesC in the beech stand and 3.1 degreesC in the oak stand. Based solely on temperature change, ASPECTS predicted an increase in transpiration of 17% in the beech and 6% in the oak stand, the difference being due to variation in local climate and the sensitivity of both species to D-s. Based solely on increased atmospheric CO2 (355 ppm in 1990 to 700 ppm in 2100), ASPECTS predicted that transpiration would decrease by 22% in beech and 19% in oak. With the combined scenarios of climatic change and increased atmospheric CO2, ASPECTS showed a decrease of 7% in transpired water in the oak stand and only 4% in the beech stand, which are not significant differences from zero. Consequently, water stress should not increase in either stand during the 21st century. (C) 2002 Elsevier Science B.V All rights reserved. [less ▲]

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See detailAccidental radiogenic ulcer of the fingers in an industrial setting.
Heymans, Olivier; Van Zeele, D.; Arrese Estrada, Jorge ULg et al

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

The incidence of accidental radiogenic damage to the skin is low. We report a case of delayed ulcerative contact radiodermatitis following accidental industrial exposure. Recurrent ulcerations of the ... [more ▼]

The incidence of accidental radiogenic damage to the skin is low. We report a case of delayed ulcerative contact radiodermatitis following accidental industrial exposure. Recurrent ulcerations of the fingers were treated successfully by flap surgical reconstruction. [less ▲]

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See detailL'école médicale d'Alexandrie et son influence sur la médecine de l'Egypte gréco-romaine
Marganne, Marie-Hélène ULg

in Medicina nei Secoli : Arte e Scienza (2002), 14(2), 359-82

The paper provides new information on the most famous centre of rational medicine in the Graeco-Roman world and its influence in Egypt. It uses at its point of departure a remarkable but insufficiently ... [more ▼]

The paper provides new information on the most famous centre of rational medicine in the Graeco-Roman world and its influence in Egypt. It uses at its point of departure a remarkable but insufficiently known documentation: Greek literary papyri (from IV/III B.C. to A.D. VI/VII), which often are unique witnesses to lost medical works, bearing testimony to original theories, practices and vocabulary. [less ▲]

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See detailAndrogenic alopecia and stress-induced premature senescence by cumulative ultraviolet light exposure.
Franchimont, Claudine ULg; Uhoda, I.; Saint Léger, Didier et al

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair ... [more ▼]

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair shedding and androgenic alopecia (AGA) is largely unknown. Objective : To compare the severity of AGA with the extent in solar elastosis. Method : The present study combining immunohistochemistry and computerized image analysis was undertaken in 140 men with AGA and 50 non-alopecic men. Solar elastosis was identified using the antibody to lyzozyme, and collagen was revealed by sirius red staining. The number and diameter of hair shafts were also assessed. Results : The scalp dermis was significantly thicker in AGA than in unaffected subjects. The difference was mainly due to a more severe elastosis in baldness. The earliest signs of solar elastosis preceded hair thinning. When elastosis was thicker than 0.2 mm, a negative exponential correlation was found between hair diameter and severity in solar elastosis. Conclusion : Chronic UVR exposure of the scalp may affect the hair cycle and be one exogenous factors influencing negatively the progression of AGA. The induction of stress-induced premature senescence (SIPS) through reactive oxygen species and microinflammation might be operative at the level of the follicular stem cells. [less ▲]

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See detailBlood oxygen binding in hypoxaemic calves
Cambier, Carole ULg; Clerbaux; Detry, Bruno et al

in Veterinary Research (2002), 33(3), 283-290

Blood oxygen transport and tissue oxygenation were studied in 28 calves from the Belgian White and Blue breed (20 healthy and 8 hypoxaemic ones). Hypoxaemic calves were selected according to their high ... [more ▼]

Blood oxygen transport and tissue oxygenation were studied in 28 calves from the Belgian White and Blue breed (20 healthy and 8 hypoxaemic ones). Hypoxaemic calves were selected according to their high respiratory frequency and to their low partial oxygen pressure (PaO2) in the arterial blood. Venous and arterial blood samples were collected, and 2,3-diphosphoglycerate, adenosine triphosphate, chloride, inorganic phosphate and hemoglobin concentrations, and pH, PCO, and PO2 were determined. An oxygen equilibrium curve (OEC) was measured in standard conditions, for each animal. The arterial and venous OEC were calculated, taking body temperature, pH and PCO2 values in arterial and venous blood into account. The oxygen exchange fraction (OEF%), corresponding to the degree of blood desaturation between the arterial and the venous compartments, and the amount of oxygen released at the tissue level by 100 mL of blood (OEF Vol%) were calculated from the arterial and venous OEC combined with the PO2 and hemoglobin concentration. In hypoxaemic calves investigated in this study, the hemoglobin oxygen affinity, measured under standard conditions, was not modified. On the contrary, in vivo acidosis and hypercapnia induced a decrease in the hemoglobin oxygen affinity in arterial blood, which combined to the decrease in PaO2 led to a reduced hemoglobin saturation degree in the arterial compartment. However, this did not impair the oxygen exchange fraction (OEF%), since the hemoglobin saturation degree in venous blood was also diminished. [less ▲]

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See detailOptimization and validation of arsenic determination in foods by hydride generation flame atomic absorption spectrometry
Kabengera, C.; Bodart, P.; Hubert, Philippe ULg et al

in Journal of AOAC International (2002), 85(1, Jan-Feb), 122-127

A hydride generation flame atomic absorption spectrometric method was developed and optimized to quantitate arsenic (As) in foods. A wet digestion of the samples with HNO3 + H2O2 was performed and excess ... [more ▼]

A hydride generation flame atomic absorption spectrometric method was developed and optimized to quantitate arsenic (As) in foods. A wet digestion of the samples with HNO3 + H2O2 was performed and excess oxidants were eliminated by addition of hydrochloric acid and urea. As5+ in As3+ was then reduced by potassium iodide. The As3+ solution was analyzed by generation of arsine with sodium tetrahydroborate. As determination ranged from 2.5 to 20 microg/L, with a determination coefficient of 0.997. The limits of detection (LOD) and quantitation (LOQ) were 0.6 and 2.1 microg/L, respectively. The method was validated and good results were obtained for recovery, precision, accuracy, LOD, and LOQ. This method is now used to analyze foods from Rwanda. [less ▲]

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See detailMurine 5T multiple myeloma cells induce angiogenesis in vitro and in vivo
Van Valckenborgh, E.; De Raeve, H.; Devy, L. et al

in British Journal of Cancer (2002), 86(5), 796-802

Multiple myeloma is a B cell malignancy. Recently, it has been demonstrated that bone marrow samples of patients with multiple myeloma display an enhanced angiogenesis. The mechanisms involved seem to be ... [more ▼]

Multiple myeloma is a B cell malignancy. Recently, it has been demonstrated that bone marrow samples of patients with multiple myeloma display an enhanced angiogenesis. The mechanisms involved seem to be multiple and complex. We here demonstrate that the murine 5T multiple myeloma models are able to induce angiogenesis in vitro by using a rat aortic ring assay and in vivo by determining the microvessel density. The rat aortic rings cultured in 5T multiple myeloma conditioned medium exhibit a higher number of longer and more branched microvessels than the rings cultured in control medium. In bone marrow samples from 5T multiple myeloma diseased mice, a statistically significant increase of the microvessel density was observed when compared to bone marrow samples from age-matched controls. The angiogenic phenotype of both 5T multiple myeloma cells could be related, at least in part, to their capacity to produce vascular endothelial growth factor. These data clearly demonstrate that the 5T multiple myeloma models are good models to study angiogenesis in multiple myeloma and will allow to unravel the mechanisms of neovascularisation, as well as to test new putative inhibitors of angiogenesis. [less ▲]

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See detailLa libre disposition du corps humain à la lumière de la jurisprudence Perruche
Leleu, Yves-Henri ULg

in Revue Générale des Assurances et des Responsabilités (2002)

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See detailSternal recumbency or suspension by the hind legs immediately after delivery improves respiratory and metabolic adaptation to extra uterine life in newborn calves delivered by caesarean section.
Uystepruyst, Christophe; Coghe, Joost; Dorts, Thierry et al

in Veterinary Research (2002), 33(6), 709-724

The aim of this study was to evaluate the effect of body positioning immediately after delivery on respiratory and metabolic adaptation to extra-uterine life in newborn calves. One hundred and one Belgian ... [more ▼]

The aim of this study was to evaluate the effect of body positioning immediately after delivery on respiratory and metabolic adaptation to extra-uterine life in newborn calves. One hundred and one Belgian White and Blue calves were delivered at term by an elective caesarean section and were assigned into three categories according to the body position imposed immediately after umbilical cord rupture: 71 calves were placed in lateral recumbency; 16 calves were placed in sternal recumbency and 14 calves were suspended by the hind legs for less than 90 seconds (75 +/- 5 s). Following this initial body position, the calves were allowed to move without restraint. They were examined at birth, 5, 15, 30, 45 and 60 minutes, and 2, 3, 6, 12 and 24 hours after birth by the following measurements: physical examination, heart rate, arterial blood gas analysis, pulmonary function tests using the esophageal balloon catheter technique, arterial and venous blood acid-base balance analysis, rectal temperature, jugular venous blood sampling for the determination of blood glucose, plasma lactate and serum cortisol concentrations, haematologic variables and passive immune transfer variables. Body positioning immediately after delivery clearly influenced respiratory and metabolic adaptation to extra-uterine life in term calves delivered by an elective caesarean section. Systematic sternal recumbency and suspension by the hind legs for less than 90 seconds immediately after umbilical cord rupture had a positive functional impact on postnatal pulmonary mechanics and gas exchange and on postnatal correction of mixed acidosis present at birth, contributing in turn to an enhanced passive immune transfer. These two body positions should be encouraged to improve adaptation at birth in healthy term calves delivered by an elective caesarean section. Evaluation of possible side-effects is required before application in severely asphyxiated calves. [less ▲]

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See detailComment j'explore ... une métastase orpheline d'un mélanome.
Henry, Frédérique ULg; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(6), 405-7

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then ... [more ▼]

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then be performed using non invasive and clinically oriented methods. Beside a thorough skin examination, otorhinolaryngological, ophtalmic and gynecologic searches are recommended. In addition, paraclinical investigations are conducted according to the metastatic location, the gender and the functional complaints of the patient. The prognosis of these orphan metastases is not more dramatic than when the primary lesion is identified. Therapies are similar to those proposed in the classical presentation of the disease. [less ▲]

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See detailGenetic factors affecting susceptibility to udder pathogens
Detilleux, Johann ULg

in Veterinary Immunology and Immunopathology (2002), 88(3-4), 103-110

Bovine mastitis remains the most costly disease in dairy cattle. Breeding for resistance to udder pathogens has been proposed as a complementary tool to therapeutic and prophylactic measures not totally ... [more ▼]

Bovine mastitis remains the most costly disease in dairy cattle. Breeding for resistance to udder pathogens has been proposed as a complementary tool to therapeutic and prophylactic measures not totally effective against the disease. This paper reviews factors affecting cows’ susceptibility to pathogens at the animal, cellular/hormonal and DNA levels. Such factors will be useful in achieving genetic improvement for resistance only if they have desirable properties at the genetic and immunological levels. Because such properties are not always of significant magnitude, further research is necessary to identify characteristics of resistance in cows, considering the constant and complex interactions that occur between hosts and pathogens. [less ▲]

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See detailThe use of random amplified polymorphic DNA (RAPD) analysis for studies of genetic variation in populations of Coccinella septempunctata in Belgium.
Haubruge, Eric ULg; Vanlerberghe-Masutti, Flavie; Collignon, Pierre et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2002), 67(3), 557-61

The movement and dispersion of Coccinella septempunctata and its efficacy as aphid control agent over large areas is not really understood because of the difficulty in identifying the origins of predators ... [more ▼]

The movement and dispersion of Coccinella septempunctata and its efficacy as aphid control agent over large areas is not really understood because of the difficulty in identifying the origins of predators. To quantify the genetic diversity within the species and monitor the spatial foraging, populations were sampled from Belgium and analysed for RAPD DNA variation. Twenty decamer primers generated more than hundred polymorphic RAPD bands and pairwise distances were calculated between populations according to Nei and Li, then used to construct a radial neighbour-joining dendrogram and examine intra- and inter-population variance coefficients, by analysis of molecular variation (AMOVA). This study shows that while a number of factors can complicate the use and interpretation of RAPD fragments as genetic markers, RAPD analysis can be a valuable technique for studies of intra-specific genetic variation in C. septempunctata. [less ▲]

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See detailImportance et dispersion de la maladie du hêtre en Région wallonne. Premier résultats d'un inventaire spécifique
Rondeux, Jacques ULg; Bourland, Nils ULg; Huart, O. et al

in Silva Belgica (2002), 109(3), 22-30

Suite aux attaques massives de scolytes sur les hêtres de Gaume et surtout d'Ardenne au printemps 2001, un inventaire spécifique a été mené dans les hêtraies publiques de Wallonie. Les auteurs se ... [more ▼]

Suite aux attaques massives de scolytes sur les hêtres de Gaume et surtout d'Ardenne au printemps 2001, un inventaire spécifique a été mené dans les hêtraies publiques de Wallonie. Les auteurs se proposent de vous présenter une première analyse des résultats. [less ▲]

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See detailL'étude MICROHOPE
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2002), 14(5), 170-172

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See detailDifferential taurine responsiveness to ethanol in high- and low-alcohol sensitive rats : a brain microdialysis study
Quertemont, Etienne ULg; Linotte, Sylvie; De Witte, Philippe

in European Journal of Pharmacology (2002), 444(3), 143-150

Several microdialysis studies have investigated the effects of acute ethanol on extracellular amino acids in various rat brain regions, However, these studies led to conflicting results, suggesting that ... [more ▼]

Several microdialysis studies have investigated the effects of acute ethanol on extracellular amino acids in various rat brain regions, However, these studies led to conflicting results, suggesting that individual differences between rat strains and lines may play an important role. In the present study, high-alcohol sensitive (HAS) and low-alcohol sensitive (LAS) rats were used to investigate the possible relationship between ethanol sensitivity and the concentrations of extracellular amino acids in the nucleus accumbens. Several groups of HAS and LAS rats were injected with either saline or ethanol (1.0, 2.0 or 3.0 g/kg, i.p.) and the concentrations of amino acids in the nucleus accumbens microdialysates were assayed by electrochemical detection. Acute ethanol induced a dose-dependent increase in extracellular taurine concentrations. However, this increase was significantly reduced at 2,0 and 3.0 g,,kg ethanol in HAS rats relative to LAS rats. Since the biological functions of taurine suggest its implication in the reduction of ethanol adverse effects, a higher increase in taurine concentrations may contribute to the lower ethanol sensitivity of LAS rats. Although 2.0 and 3.0 g/kg ethanol did not affect extracellular glutamate concentrations, a significant increase in glutamate was observed after 1.0 g/kg ethanol to HAS rats but not to LAS rats. Such an effect remains unexplained but suggests that discrepancies between the results of previous microdialysate studies may be related to differences in the ethanol sensitivities of various rat strains. (C) 2002 Elsevier Science B.V All rights reserved. [less ▲]

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See detailAnalysis Of The C-Terminal Membrane Anchor Domains Of Hepatitis C Virus Glycoproteins E1 And E2: Toward A Topological Model
Charloteaux, Benoît ULg; Lins, Laurence ULg; Moereels, H. et al

in Journal of Virology (2002), 76(4), 1944-58

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen ... [more ▼]

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen where they remain. The 31 C-terminal residues of the E1 protein and the 29 C-terminal residues of the E2 protein are implicated in the ER retention. Moreover, the E1 and E2 C termini are implicated in E1-E2 heterodimerization. We studied the E1 and E2 C-terminal sequences of 25 HCV strains in silico using molecular modeling techniques. We conclude that both C-terminal domains should adopt a similar and peculiar configuration: one amphipathic alpha-helix followed by a pair of transmembrane beta-strands. Several three-dimensional (3-D) models were generated. After energy minimization, their ability to interact with membranes was studied using the molecular hydrophobicity potentials calculation and the IMPALA procedure. The latter simulates interactions with a membrane by a Monte Carlo minimization of energy. These methods suggest that the beta-hairpins could anchor the glycoproteins in the ER membrane at least transiently. Anchoring could be stabilized by the adsorption of the nearby amphipathic alpha-helices at the membrane surface. The 3-D models correlate with experimental results which indicate that the E1-E2 transmembrane domains are involved in the heterodimerization and have ER retention properties. [less ▲]

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See detailDe la philosophie à la sociologie en compagnie de Pierre Bourdieu
Frère, Bruno ULg

in Revue de l'Institut de Sociologie (2002), 1-4

La compréhension adéquate des influences de Pierre Bourdieu peuvent nous permettre de diversifier sa pensée comme il diversifiait lui-même celle des autres. On sait qu’il utilise Wittgenstein dès l ... [more ▼]

La compréhension adéquate des influences de Pierre Bourdieu peuvent nous permettre de diversifier sa pensée comme il diversifiait lui-même celle des autres. On sait qu’il utilise Wittgenstein dès l'élaboration de son vocabulaire critique défiant les « prénotions » et les préjugés condamnés comme étant le fruit d'une sociologie spontanée et profane qui mine le jugement objectif. Mais il le quitte au moment où celui-ci manifeste le désir de revenir « au point de vue du sens commun ». Il semble bien que nous ayons alors affaire à « une quête fervente de l'ordinaire et du familier » à laquelle Bourdieu ne se référera plus.. En tenir compte peut nous permettre d’ouvrir le dialogue avec la sociologie pragmatique de Luc Boltanski et Laurent Thévenot. A la suite de Bourdieu, c’est alors en partie avec eux qu’on peut prolonger véritablement l’exigence wittgensteinienne : étudier les « exemples primitifs des langages communs ». Ces sociologies, on le sait, accueillent a priori le discours des acteurs comme le fruit d’un travail interprétatif cohérent. Qu’ils soient « justes » ou non par rapport à l’état du monde n’est pas l’essentiel. L’enjeu n’est plus d’évaluer leur valeur de vérité par rapport à la réalité - ce qu’autorise la pensée de Bourdieu - mais d’approcher « des sujets parlants ordinaires [… ]co-énonciateurs du discours intervenant en permanence dans la construction du sens » . Tous sont capables de construire et de déconstruire leurs pratiques et ce jeu de construction-déconstruction revêt un intérêt en soi. Il s’agit moins de nier le fait qu’un langage quelconque puisse être pétri d’illusions que de chercher à en saisir la portée significative. En définitive, les objectifs de ces paradigmes sont à la fois différents et tout à fait complémentaires. Il faut à présent chercher à saisir correctement les objets sociologiques ambigus qu’une sociologie hybride permettrait d’éclairer. C'est ce que nous nous suggérons de le présent article. [less ▲]

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See detailLes débuts du paléolithique supérieur dans le nord-ouest de l’Europe : le Lincombien-Ranisien-Jerzmanowicien (état de la question)
Flas, Damien ULg

in Anthropologica et Praehistorica : Bulletin de la Société Royale Belge d'Anthropologie et de Préhistoire (2002), 113

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See detailComment etablir le bilan de fin de traitement des patients atteints de lymphomes non-hodgkiniens (LNH) de malignite intermediaire ou elevee?
Warland, V.; Jerusalem, Guy ULg; Hustinx, Roland ULg et al

in Revue Médicale de Liège (2002), 57(12), 779-84

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to ... [more ▼]

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to use salvage therapy and possibly hematopoietic stem cell transplantation at the time of minimal disease rather than at the time of clinically overt relapse. The authors reviewed the most appropriate imaging techniques for the assessment of response to treatment. The limitations of CT and MRI for predicting the nature of residual masses are well known. 67Ga scintigraphy has become a standard procedure for the posttreatment evaluation of patients with lymphoma, but it appears that 18F-FDG PET may be a more effective method. Personal experience in the field of PET scan is reported. Although PET should be considered the noninvasive imaging modality of choice, a histological confirmation of residual disease is always necessary before starting salvage therapy. 18F-fluorodeoxyglucose is not a tumor specific radiotracer. [less ▲]

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See detailPrognosis of hematologic malignancies does not predict intensive care unit mortality.
MASSION, Paul ULg; Dive, Alain M; Doyen, Chantal et al

in Critical Care Medicine (2002), 30(10), 2260-70

OBJECTIVE: To evaluate the correlation between specific prognosis of hematologic malignancies on the one hand and intensive care unit and hospital mortality in critically ill patients with hematologic ... [more ▼]

OBJECTIVE: To evaluate the correlation between specific prognosis of hematologic malignancies on the one hand and intensive care unit and hospital mortality in critically ill patients with hematologic malignancies on the other hand. DESIGN: Observational study during a 10-yr period. SETTING: A 22-bed medical-surgical intensive care unit. PATIENTS: A total of 84 consecutive patients with nonterminal hematologic malignancies with medical complications requiring intensive care. INTERVENTIONS: None. MEASUREMENTS: Demographic factors, acute physiology and organ dysfunction scores, microbiology, therapeutic support, and hematologic factors data on admission and during the intensive care unit stay were collected, together with mortality follow-up. Based on specific-disease prognostic factors and related published survival curves, the prognosis of hematologic malignancies was assessed and defined as good, intermediate, or poor according to a 3-yr survival probability of >50%, 20-50%, or <20%, respectively. MAIN RESULTS: Prognosis of hematologic malignancies does not predict intensive care unit or hospital mortality and almost reaches significance for 6-mo mortality (53%, 71%, and 84% rate for patients with good, intermediate, and poor prognosis, respectively, p =.058), but it determines long-term survival (p =.008). Intensive care unit, hospital, and 6-mo overall mortality rates were 38%, 61%, and 75%, respectively. Using multivariate analysis, intensive care unit mortality was best predicted on admission by respiratory failure and fungal infection, whereas hospital mortality was predicted by the number of organ failures, the bone marrow transplant status, and the presence of fungal infection. The Acute Physiology and Chronic Health Evaluation II and the Simplified Acute Physiology Score II had no prognostic value, whereas the difference of the Multiple Organ Dysfunction Score between at the time of admission and at day 5 allowed quick prediction of hospital mortality. Diseases with the poorest 6-mo prognosis were acute myeloid leukemia and non-Hodgkin lymphoma. CONCLUSION The severity of the underlying hematologic malignancies does not influence intensive care unit or hospital mortality. Short-term prognosis is exclusively predicted by acute organ dysfunctions and by a pathogen's aggressiveness. Therefore, reluctance to admit patients with nonterminal hematologic malignancies to the intensive care unit based only on the prognosis of their underlying hematologic malignancy does not seem justified. [less ▲]

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See detailUncoupling proteins outside the animal and plant kingdoms: functional and evolutionary aspects.
Sluse, Francis ULg; Jarmuszkiewicz, W.

in FEBS Letters (2002), 510

The appearance of intracellular oxidative phosphorylation at the time of acquisition of mitochondria in Eukarya was very soon accompanied by the emergence of uncoupling protein, a carrier specialized in ... [more ▼]

The appearance of intracellular oxidative phosphorylation at the time of acquisition of mitochondria in Eukarya was very soon accompanied by the emergence of uncoupling protein, a carrier specialized in free fatty acid-mediated H(+) recycling that can modulate the tightness of coupling between mitochondrial respiration and ATP synthesis, thereby maintaining a balance between energy supply and demand in the cell and defending cells against damaging reactive oxygen species production when electron carriers of the respiratory chain become over-reduced. The simultaneous occurrence of redox free energy-dissipating oxidase, which has the same final effect, could be related to the functional interactions between both dissipative systems [less ▲]

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See detailChanges in motor unit numbers in patients with ALS: a longitudinal study using the adapted multiple point stimulation method.
Wang, François-Charles ULg; Bouquiaux, Olivier ULg; De Pasqua, Victor ULg et al

in Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders (2002), 3(1), 31-8

METHOD: The adapted multiple point stimulation (AMPS) method for calculating motor unit numbers (MUNE) was applied in 12 patients with amyotrophic lateral sclerosis (ALS) before riluzole therapy (T(0 ... [more ▼]

METHOD: The adapted multiple point stimulation (AMPS) method for calculating motor unit numbers (MUNE) was applied in 12 patients with amyotrophic lateral sclerosis (ALS) before riluzole therapy (T(0)) and again after 4, 8 and 12 months of treatment. RESULTS: Paired Student's t-test indicated a significant decrease of thenar MUNE and compound muscle action potential (CMAP) size at each 4-monthly interval, while average surface motor unit potential (SMUP) size did not change significantly over time. The rate of motor unit (MU) loss at month 4 was more than 20% in six patients (group 1) and less than 20% in six other patients (group 2). Comparison of groups 1 and 2 by Mann-Whitney U-testing indicated that percent changes in thenar MUNE and CMAP size compared to baseline were significantly different at months 4, 8 and 12, while no difference between the two groups was found for average SMUP size variations. In the group with a slow rate of MU loss, CMAP size remained stable, while in the group with a rapid rate of MU loss, there was a dramatic reduction in size of the CMAP. A positive correlation was found between percent change in thenar MUNE at T(4) and at T(12) (P < 0.001). CONCLUSION: AMPS is a useful technique to document MUNE, SMUP size and CMAP size changes over time in patients with ALS. [less ▲]

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See detailRemarques sur le vocabulaire grec de la traduction
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (2002), 80

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See detailA quinze ans, trop de jeunes sont brouillés avec la lecture
Lafontaine, Dominique ULg

in Caractères (2002), 7

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