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See detailMiospores from the type locality of the middle Famennian Esneux Formation in the Ourthe Valley, eastern Belgium
Loboziak, S; Avkhimovich, V I; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1996), 119(2), 111-118

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See detailGlycoprotein H (gII/gp108) and glycoprotein L form a functional complex which plays a role in penetration, but not in attachment, of bovine herpesvirus 1.
van Drunen Littel-van den Hurk, S.; Khattar, S.; Tikoo, S. K. et al

in Journal of General Virology (The) (1996), 77 ( Pt 7)

The glycoproteins of bovine herpesvirus 1 (BHV-1) play important roles in the interactions between virions and target cells. A 108 kDa glycoprotein, designated gII or gp 108, has been identified by two ... [more ▼]

The glycoproteins of bovine herpesvirus 1 (BHV-1) play important roles in the interactions between virions and target cells. A 108 kDa glycoprotein, designated gII or gp 108, has been identified by two different panels of monoclonal antibodies. The gII- and gp 108-specific monoclonal antibodies were shown to react with the same protein, which was identified by N-terminal sequencing as the homologue of herpes simplex virus type 1 (HSV-1) gH. When BHV-1 gH was purified by immunoadsorbent chromatography, gL was co-purified. The gH-gL complex induced the production of antibodies that neutralized virus infectivity and inhibited virus penetration. Affinity-purified gH-gL did prevent penetration, but not attachment of BHV-1, which suggests that the gH-gL complex is essential for penetration of BHV-1 into susceptible cells. [less ▲]

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See detailThe Use Of N-15-Labeled Dietary Proteins For Determining True Ileal Amino Acid Digestibilities Is Limited By Their Rapid Recycling In The Endogenous Secretions Of Pigs
Leterme, Pascal; Thewis, André ULg; Francois, Etienne et al

in Journal of Nutrition (1996), 126(9), 2188-2198

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary ... [more ▼]

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary N excretion pattern at the ileum subsequent to the ingestion of a single 15N-labeled meal. In a second experiment, we compared ileal endogenous AA outputs and true AA digestibility estimates obtained in pigs ingesting 15N-labeled dietary proteins in a single meal vs. intravenous infusion of 15N-leucine for 10 d during the ingestion of a pea-based diet and a protein-free starch diet. The proportion of endogenous N found in the ¡leal digesta differed when the label was delivered orally (50%) vs. intravenously (72%) and changed with time. As a consequence, the true ileal AA digestibilities measured with labeled diets were lower. A third experiment demonstrated that this was due to the rapid recycling of labeled dietary N in endogenous moieties, because 15N was found in blood within 10 min of consuming the labeled meal, within 50 min of consumption in pancreatic enzymes, 90 min in bile and 4 h in ¡leal mucins. We conclude that the use of 15N-labeled meals for determination of true ¡leal AA digestibilities is limited by the fast recycling of dietary N in endogenous secretions following a single 15N-labeled meal. The accuracy of results will depend on meaningful estimates of AA flow during a limited period and accurate estimates of 15N in AA. [less ▲]

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See detailLocalisation respiratoire d'un lymphosarcome cutané chez un cheval.
Anciaux, Nathalie; Amory, Hélène ULg

in Pratique Vétérinaire Equine (1996), 28

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See detailCharacterization of the potato mitochondrial transcription unit containing 'native' trnS (GCU), trnF (GAA) and trnP (UGG)
Remacle, Claire ULg; MarechalDrouard, L.

in Plant Molecular Biology (1996), 30(3), 553-563

In order to identify the sequences promoting the expression of plant mitochondrial tRNA genes, we have characterized the trnS (GCU), trnF (GAA) and trnP (UGG) transcription unit of the potato ... [more ▼]

In order to identify the sequences promoting the expression of plant mitochondrial tRNA genes, we have characterized the trnS (GCU), trnF (GAA) and trnP (UGG) transcription unit of the potato mitochondrial genome. These three tRNA genes were shown to be co-transcribed as a 1800 nt long primary transcript. The transcription initiation site located 305 to 312 nt upstream of trnS is surrounded by a purine-rich region but does not contain the consensus motif proposed as a promoter element in dicotyledonous plants. Differential labelling of potato mitochondrial RNA with either guanylyltransferase or T4 polynucleotide kinase suggests that this site corresponds to the unique functional region responsible for the transcription of these three tRNA genes. The initiation site recently found upstream of Oenothera mitochondrial rr trnF does not seem to be used in potato mitochondria, although a very similar sequence is present 317 nt upstream of the corresponding potato gene. Major processing sites were identified at the 3' end of each tRNA gene. Another processing site, surrounded by a double hairpin structure, is located 498 nt downstream of trnP in stretch of 10 A residues. As judged from northern experiments, this region is close to the determination site of this transcription unit. [less ▲]

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See detailPrediction of response to recombinant human erythropoietin (rHuEpo) in anemia of malignancy.
Cazzola, M.; Ponchio, L.; Pedrotti, C. et al

in Haematologica (1996), 81(5), 434-41

BACKGROUND: Since only a portion of anemic patients outside the uremia setting benefit from erythropoietin treatment, a reliable means of predicting potential responders and nonresponders would be very ... [more ▼]

BACKGROUND: Since only a portion of anemic patients outside the uremia setting benefit from erythropoietin treatment, a reliable means of predicting potential responders and nonresponders would be very useful. MATERIALS AND METHODS: We retrospectively reviewed the clinical records of 58 patients with refractory anemia associated with various malignant disorders who had been treated with subcutaneous rHuEpo. The starting rHuEpo dose was 375 U/kg/week for 4 weeks, and was increased to 750 U/kg/week for another 4 weeks if no response was observed. Response was defined as a Hb increase > or = 2 g/dL with no need for blood transfusion. We examined the value of various laboratory parameters (baseline levels, 2-week and 4-week changes) as predictors of response. Endogenous erythropoietin production was evaluated by its serum level and erythroid activity was assessed through reticulocyte count and circulating transferrin receptor. RESULTS: Forty-eight individuals were evaluable, 58% of whom responded to rHuEpo within 8 weeks. Multiple regression analysis showed that 53% of the variation in the 8-week Hb concentration was explained by variations in baseline serum erythropoietin and the 2-week change in serum transferrin receptor (p < 0.001). Based on these two parameters, response prediction in individual patients would have resulted in a sensitivity of 96%, a specificity of 79% and an overall accuracy of 88%. In addition, 58% of the variation in the 8-week Hb was explained by variations in the 4-week changes in Hb and reticulocyte count (p < 0.001). Utilizing these latter parameters and baseline serum erythropoietin, response prediction in individual patients would have resulted in a sensitivity of 92%, a specificity of 82% and an overall accuracy of 88%. CONCLUSIONS: This retrospective analysis suggests that response to rHuEpo can be reasonably predicted by pretreatment serum erythropoietin together with early changes in simple laboratory parameters. [less ▲]

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See detailImpairement of Memory for spatial Context in Schizophrenia
Rizzo, L.; Danion, J.M.; Van der Linden, Martial ULg et al

in Neuropsychology (1996), 10

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See detailRevascularisation rénale pour sauvetage ou préservation néphronique
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Gillain et al

in Revue Médicale de Liège (1996), 51(2), 175-86

La néphropathie ischémique est une entité de plus en plus fréquente, à cause du vieillissement de la population et du contrôle médicamenteux de l'hypertension. Une ischémie de l'ensemble de la masse ... [more ▼]

La néphropathie ischémique est une entité de plus en plus fréquente, à cause du vieillissement de la population et du contrôle médicamenteux de l'hypertension. Une ischémie de l'ensemble de la masse rénale (sténoses serrées concernant les deux reins ou un rein unique) compromet la filtration glomérulaire et constitue une des rares formes d'insuffisance rénale chronique réversible. Actuellement, 30 à 50% des patients sélectionnés pour une revascularisation rénale ont une fonction rénale altérée. L'histoire naturelle des sténoses rénales (surtout les lésions athéroscléreuses) montre une évolutivité vers l'obstruction progressive avec perte de parenchyme fonctionnel. Une revascularisation rénale envisage soit la protection du capital néphronique (intervention prophylactique), soit un sauvetage néphronique (restauration ou stabilisation d'une fonction rénale déjà altérée). Les critères prédictifs de bénéfice à long terme sont analysés. Les rôles respectifs de l'angioplastie transluminale percutanée et de la chirurgie sont discutés. L'intérêt de la revascularisation rénale sur la fonction rénale a été apprécié chez 23 malades réno-vasculaires et azotémiques (créatinine > 20 mg/l) ainsi que chez 8 patients en oligoanurie d'origine ischémique. [less ▲]

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See detailThe degree/rapidity of the metabolic deterioration following interruption of a continuous subcutaneous insulin infusion is influenced by the prevailing blood glucose Level.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Journal of Clinical Endocrinology and Metabolism (1996), 81(5), 1975-8

This study aims at investigating the influence of the prevailing blood glucose level on the metabolic deterioration that follows a nocturnal interruption of a continuous sc insulin infusion (CSII ... [more ▼]

This study aims at investigating the influence of the prevailing blood glucose level on the metabolic deterioration that follows a nocturnal interruption of a continuous sc insulin infusion (CSII). Fifteen CSII-treated, C-peptide negative, diabetic patients have been studied CSII was interrupted from 2300 h to 0500 h. Blood was collected hourly from 2200 h to 0600 h. According to blood glucose (BG) levels at 2300 h, patients were classified as hypoglycemic (BG between 1.5 and 2.5 mmol/L, n = 5), normoglycemic (BG between 4.0 and 8.0 mmol/L, n = 5), or hyperglycemic (BG between 9.0 and 15.0 mmol/L, n = 5). At 2300 h, BG (mean +/- SEM) was 1.9 +/- 0.1, 6.2 +/- 0.7 and 11.2 +/- 1.0 mmol/L, respectively. After 6 h of CSII interruption, BG increased to 13.5 +/- 1.3, 14.1 +/- 1.2, and 19.4 +/- 1.2 mmol/L, respectively. At 2300 h, plasma 3-OH-butyrate levels were similar in the three groups (around 150 micromol/L). At 0500 h, significantly higher values were obtained for hyperglycemic (1460 +/- 127 micromol/L) than for normoglycemic (868 +/- 150 micromol/L) or hypoglycemic (837 +/- 80 micromol/L) patients. Enhanced lipolysis in initially hyperglycemic patients may contribute to accelerated ketogenesis and metabolic degradation. In conclusion, the metabolic deterioration that follows CSII interruption is influenced by the initial metabolic situation. Hypoglycemic patients deteriorate more rapidly, and hyperglycemic patients suffer a more important degradation. The latter are prone to rapid ketoacidosis if accidental CSII interruption occurs. [less ▲]

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See detailEx-vivo cytokine production by whole blood cells from cancer patients
De Groote, Donat; Vrindts-Gevaert, Yvonne; Lopez Y Cadenas, Miguel ULg et al

in Cancer Detection & Prevention (1996), 20

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See detailUne statuette d'adorant de l'âge du Bronze ancien provenant de Tell Amarna (Syrie)
Tunca, Önhan ULg

in Colloctanea Orientalia. Histoire, arts de l'espace et industrie de la terre. Etudes offertes en hommage à Agnès Spycket (1996)

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See detailDevelopmental and evolutionary aspects of thymic T-cell education to neuroendocrine self
Geenen, Vincent ULg; Benhida, Abdellah; Kecha, Ouafae et al

in Acta Haematologica (1996), 95

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See detailModulation Of Cd3-Gamma Gene Expression After Hiv Type 1 Infection Of The We17/10 T Cell Line Is Progressive And Occurs In Concert With Decreased Production Of Viral P24 Antigen
Willardgallo, Ke.; Delmellewibaut, C.; Segurazapata, I. et al

in Aids Research and Human Retroviruses (1996), 12(8),

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See detailDefective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis.
Cazzola, M.; Ponchio, L.; de Benedetti, F. et al

in Blood (1996), 87(11), 4824-30

Systemic-onset juvenile chronic arthritis (SoJCA) is associated with high levels of circulating interleukin-6 (IL-6) and is frequently complicated by severe microcytic anemia whose pathogenesis is unclear ... [more ▼]

Systemic-onset juvenile chronic arthritis (SoJCA) is associated with high levels of circulating interleukin-6 (IL-6) and is frequently complicated by severe microcytic anemia whose pathogenesis is unclear. Therefore, we studied 20 consecutive SoJCA patients with hemoglobin (Hb) levels <12 g/dL, evaluating erythroid progenitor proliferation, endogenous erythropoietin production, body iron status, and iron supply for erythropoiesis. Hb concentrations ranged from 6.5 to 11.9 g/dL. Hb level was directly related to mean corpuscular volume (r = .82, P < .001) and inversely related to circulating transferrin receptor (r = -.81, P < .001) suggesting that the severity of anemia was directly proportional to the degree of iron-deficient erythropoiesis. Serum ferritin ranged from 18 to 1,660 microgram/L and was unrelated to Hb level. Bone marrow iron stores wore markedly reduced in the three children investigated, and they also showed increased serum transferrin receptor and normal-to-high serum ferritin. All 20 patients had elevated IL-6 levels and normal in vitro growth of erythroid progenitors. Endogenous erythropoietin (epo) production was appropriate for the degree of anemia as judged by both the observed to predicted log (serum epo) ratio 10.95 +/- 0.12) and a comparison of the serum epo-Hb regression found in these subjects with that of thalassemia patients. Multiple regression analysis showed that serum transferrin receptor was the parameter most closely related to hemoglobin concentration: variation in circulating transferrin receptor explained 61% of the variation in Hb level (P < .001). In 10 severely anemic patients, amelioration of anemia following intravenous iron administration resulted in normalization of serum transferrin receptor. Defective iron supply to the erythron rather than blunted epo production is the major cause of the microcytic anemia associated with SoJCA. A true body-iron deficiency caused by decreased iron absorption likely complicates long-lasting inflammation in the most anemic children, and this can be recognized by high serum transferrin receptor levels. Although oral iron is of no benefit, intravenous iron saccharate is a safe and effective means for improving iron availability for erythropoiesis and correcting this anemia. Thus, while chronically high endogenous IL-6 levels do not appear to blunt epo production, they are probably responsible for the observed abnormalities in iron metabolism. Anemia of chronic disease encompasses a variety of anemic conditions whose peculiar features may specifically correlate with the type of cytokine(s) predominantly released. [less ▲]

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See detailRemarques sur le bilinguisme gréco-latin
Rochette, Bruno ULg

in Etudes Classiques (Namur, Belgium) (1996), 64

Réflexions sur la coexistence de l'emploi des langues grecque et latine dans le monde méditerranéen antique, ce phénomène étant considéré principalement sous son aspect littéraire, dans une perspective ... [more ▼]

Réflexions sur la coexistence de l'emploi des langues grecque et latine dans le monde méditerranéen antique, ce phénomène étant considéré principalement sous son aspect littéraire, dans une perspective diachronique. Les pionniers de la littérature latine furent des affranchis de langue grecque qui s'exprimaient en latin. Dès la fin du deuxième siècle av. J.-C., même si l'apport des affranchis grecs à l'histoire romaine reste important, de nombreux Romains cultivés s'expriment en grec. Devant les ressources qu'offre la langue grecque, plus d'un auteur latin, jusqu'à la fin de la République, déplore la « patrii sermonis egestas ». Mais Cicéron affirme la richesse du lexique latin et entreprend avec un grand souci d'exactitude des traductions du grec en latin. Finalement, durant toute la période impériale, les deux langues se complètent et s'équilibrent. [less ▲]

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See detailCan Motor Recovery in Stroke Patients Be Predicted by Early Transcranial Magnetic Stimulation ?
Rapisarda, Giuseppe; Bastings, Eric; MAERTENS DE NOORDHOUT, Alain ULg et al

in Stroke (1996), 27(12), 2191-2196

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See detailEffects of castration on fear reactions of male sheep.
Vandenheede, Marc ULg; Bouissou, Marie-France

in Applied Animal Behaviour Science (1996), 47

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See detailTchétchénie: histoire d'un conflit
Bachkatov, Nina ULg; Wilson, Andrew

in Etudes Internationales (1996), 27(4),

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See detailMeasurement of tomato firmness by using a non-destructive mechanical sensor
Lesage, Patrick; Destain, Marie-France ULg

in Postharvest Biology & Technology (1996), 8

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate ... [more ▼]

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate lever mechanism. A highly significant correlation exists between firmness measurements performed with this device and the Stable Micro Systems (SMS), fitted with the same plunger dimaeter. Using the Cantifruit, data related to firmness variability and changes are easily obtained. The firmness of tomatoes varies about 12 % around its circumference. In a single lot of tomatoes picked at the same time, the variability may exceed 25 %. If the tomatoes are stored at 4-5 °C and 92-99 % relative humidity (RH), their firmness decreases by about 20 % over ten days. [less ▲]

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See detailFormal Methods: State of the Art and Future Directions
Clarke, Edmund M; Wing, Jeannette M; Alur, Rajeev et al

in ACM Computing Surveys (1996), 28(4), 626--643

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See detailIn vitro evaluation of lipid matrices for the development of a sustained-release sulfamethazine bolus for lambs
Evrard, Brigitte ULg; Delattre, Luc ULg

in Drug Development & Industrial Pharmacy (1996), 22(2), 111-118

The aim of this study is the development of a high-density bolus to be given to lambs in order to release sulfamethazine during 4 days after a single oral administration. The suitability of 12 lipid ... [more ▼]

The aim of this study is the development of a high-density bolus to be given to lambs in order to release sulfamethazine during 4 days after a single oral administration. The suitability of 12 lipid matrix formulations was assessed in order to maintain the integrity of the tablet even after complete dissolution of the active substance. The influence of both nature and concentration of the lipid excipient on the in vitro release of sulfamethazine was investigated. The influences of the granulation method and of the compression force were assessed on a formulation containing Cutina® HR as a binding and sustained-release agent. Finally, stability tests showed that the in vitro release characteristics remain unchanged during storage. [less ▲]

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See detailVariations interannuelles des précipitations mensuelles et leur répartition spatiale en Belgique
Alexandre, Jean ULg; Mabille, Georges ULg; Erpicum, Michel ULg

in Publication Association Internationale de Climatologie (1996), 9

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See detailAnalysis of structural members under elevated temperature conditions- Discussion
Franssen, Jean-Marc ULg

in Journal of Structural Engineering (1996), 10

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See detailNéphropathie tubulo-interstitielle aigue avec uvéite: à propos d'un cas
Weber, T.; Beckers, C.; Kaye, O. et al

in Acta Clinica Belgica (1996), 51(1), 53-56

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment ... [more ▼]

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment needed to reach the diagnosis. The evolution is unusually favourable with steroid therapy. [less ▲]

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See detailComparison of Neuromuscular Block of Atracurium and Rocuronium in Adults
Hans, Pol ULg; Brichant, Jean-François ULg; Franzen, A. et al

in Acta Anaesthesiologica Belgica (1996), 47(2), 53-8

We studied the time-course of action of atracurium 0.5 mg kg-1 and rocuronium 0.6 mg kg-1 in 24 healthy adult patients. Anesthesia was induced with thiopentone and sufentanil, and maintained with 50 ... [more ▼]

We studied the time-course of action of atracurium 0.5 mg kg-1 and rocuronium 0.6 mg kg-1 in 24 healthy adult patients. Anesthesia was induced with thiopentone and sufentanil, and maintained with 50% nitrous oxide and 1% enflurane in oxygen. Neuromuscular transmission was monitored by stimulating the ulnar nerve at the wrist and measuring the acceleration of the thumb using the TOF-Guard accelerograph monitor. Supramaximal stimuli of 0.2 ms duration were applied in a single twitch stimulation mode at 1 Hz frequency until completion of block, and in train-of four (TOF) sequence at 2 Hz every 15 sec thereafter. Onset time was longer with atracurium (mean +/- SD:90 +/- 18 sec) than with rocuronium (49 +/- 6 sec). Clinical duration of action (Tl25) was longer with atracurium (52.3 +/- 7.2 min) than with rocuronium (40.0 +/- 6.4 min). Recovery index (Tl25-Tl75) and time for TOF ratio to recover to 0.75 were 17.8 +/- 4.2 and 73.9 +/- 8.8 min with atracurium, and 13.8 +/- 4.1 and 70.4 +/- 14.1 min with rocuronium. The differences between both groups were statistically significant except the difference in the time for TOF to return to 0.75. [less ▲]

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See detailFirst approach on the skull morphology of the black rat (Rattus rattus) from Terceira and São Miguel islands (Azores archipelago)
Ramalhinho, Maria da Graça; Mathias, Maria da Luz; Santos Reis, Margarita et al

in Vie et milieu (1996), 46(3-4), 245-251

The present paper deals with an analysis of metric (cranial measurements) and non metric (epigenetic cranial characters) variation in black rat populations from S. Miguel and Terceira islands compared to ... [more ▼]

The present paper deals with an analysis of metric (cranial measurements) and non metric (epigenetic cranial characters) variation in black rat populations from S. Miguel and Terceira islands compared to a continental sample. Assuming the Azorean rats originate from the European continent, we tested the similarity between the samples, considering only adult and subadult animals. Having verified that there was no sexual dimorphism in the characters studied, we computed discriminant functions and made a PCA with the most discriminant variables. The three samples are clearly separated by these functions, the Azorean rats showing a larger general skull size and differing between the two islands. The Mean Measure of Divergence (MMD), based on non metric cranial traits frequencies, was also used to express the interpopulational differences: the rats of Terceira differ significantly either from the continental ones or from those of S. Miguel. Finally, the possible origin of these differences is disussed. [less ▲]

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See detailLe juste entre l’universel et le contextuel. Le débat anglo-saxon contemporain et son apport pour une approche socio-anthropologique du sens ordinaire de la justice dans un pays de tradition arabo-islamique
Nachi, Mohamed ULg

in Social Science Information/Information sur les sciences sociales (1996), 35(2), 389-425

Le présent article met en évidence les pertinences de l'idée d'un recours à la pensée philosophique pour mieux asseoir une approche socio-anthropologique du sens ordinaire de la justice. Pour se faire, l ... [more ▼]

Le présent article met en évidence les pertinences de l'idée d'un recours à la pensée philosophique pour mieux asseoir une approche socio-anthropologique du sens ordinaire de la justice. Pour se faire, l'auteur se propose d'analyser les présupposés épistémologiques et théoriques des trois courants philosophiques anglo-saxons qui placent au centre de leurs réflexions la question de la justice. Il montre, ce faisant, les limites de la thèse "libérale" et les apports respectifs des thèses marxienne et communautarienne. Certaines positions théoriques d'auteurs dits communautariens se révèlent plus pertinentes dans la mesure où elles permettent de situer la question de la justice à l'intérieur d'une tradition et de lui conférer un contenu socio-historique. Elles débouchent, de ce fait, sur une conception pluraliste de la justice qui permet de prendre en compte les données empiriques propres à une société de tradition arabo-islamique. [less ▲]

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See detailAssessment of nuclear totipotency of fetal bovine diploid germ cells by nuclear transfer.
Moens, A.; Chesne, P.; Delhaise, F. et al

in Theriogenology (1996), 46(5), 871-80

Nuclear transfer was used to study nuclear reprogramming of fetal diploid bovine germ cells collected at two stages of the fetal development. In the first case, germ cells of both sexes were collected ... [more ▼]

Nuclear transfer was used to study nuclear reprogramming of fetal diploid bovine germ cells collected at two stages of the fetal development. In the first case, germ cells of both sexes were collected during their period of intragonadal mitotic multiplication at 48 days post coitum (d.p.c.). In the second case, only male germ cells were collected after this period, between 105 and 185 d.p.c. Isolated germ cells were fused with enucleated oocytes. Reconstituted embryos were cultured in vitro and those reaching the compacted morula or blastocyst stage were transferred into synchronous recipient heifers. Of 511 reconstituted embryos with 48 d.p.c. germ cells (309 males and 202 females), 48% (247/511 ) cleaved; 2.7% (14/511 ) reached the compacted morula stage and 8 of them the blastocyst stage (1.6%). No difference was observed between sexes. All 14 compacted morulae/blastocysts were transferred into 6 recipients and one pregnancy was initiated. This recipient was slaughtered at Day 35 and an abnormal conceptus (extended trophectoderm and degenerated embryo) was collected. Its male sex, genetically determined, corresponded to that of donor fetus. Of 380 reconstituted embryos with male 105 to 185 d.p.c. germ cells, 72.1% (274/380 ) cleaved, 2.1% (8 380 ) reached the compact morula stage and 7 of these the blastocyst stage (1.8%). Three blastocysts and one morula were transferred into 4 recipients. Two became pregnant at Day 21 but only one at Day 35 which aborted around Day 40. Our results show that the nucleus of diploid bovine germ cells of both sexes can be reprogrammed. However, in the absence of further development of these reconstituted embryos, nuclear totipotency of bovine diploid germ cells remains to be evidenced. [less ▲]

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See detailAntipeptide antibody against the bovine IGF-BP-2 : application to the detection of BST-treated cows
Scippo, Marie-Louise ULg; Degand, Guy ULg; Duyckaerts, Anne et al

in Food & Agricultural Immunology (1996), 8

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See detailDélocalisation d'une division de l'entreprise et intérêt social
Thirion, Nicolas ULg

in Revue pratique des sociétés (1996), (1), 60-90

Les titulaires d'intérêts catégoriels dans une société (tels que les travailleurs) disposent-ils d'un droit d'agir en justice au nom de l'intérêt social, à la suite de la décision de délocalisation de l ... [more ▼]

Les titulaires d'intérêts catégoriels dans une société (tels que les travailleurs) disposent-ils d'un droit d'agir en justice au nom de l'intérêt social, à la suite de la décision de délocalisation de l'activité sociétaire? [less ▲]

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See detailChemotaxis-Promoting and Adhesion Properties of Human Tonsillar Follicular Dendritic Cell Clusters
Bouzahzah, F.; Antoine, Nadine ULg; Simar, Léon ULg et al

in Research in Immunology (1996), 147(3, Mar-Apr), 165-73

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role ... [more ▼]

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role played by FDCs in attracting and binding cells. FDCs prepared from human tonsils by mild separation techniques appeared in the form of clusters (FDC clusters), where, via cytoplasmic extensions, they enveloped lymphoid cells. Using Boyden's chambers, we demonstrated that these FDC clusters produced one or more chemoattractants capable of inducing chemotaxis of lymphoid cells. Supernatants of FDC cluster cultures also exerted a chemotaxis-promoting effect. FDC clusters induced true chemotaxis, not merely chemokinesis due to cell activation. They secreted a substance or substances that stuck to the substrate (a cellulose filter) and thus induced haptotaxis. B as well as T cells were attracted, but B cells apparently required the presence of T cells to respond fully to the chemoattractant(s). Subtypes of B cells (IgD+ and IgD-) and T cells (CD4+, CD8+, CD57+ AND CD57-) were tested and all were attracted. Since purified lymphoid cells did not induce these phenomena, FDCs were suspected to do so. FDCs have been shown to establish contact with lymphoid cells. Here we have determined that CD4+ T cells adhere in greater number to FDC clusters than do CD8+ T cells. We thus propose that FDCs specifically contribute to construction of lymph follicles by attracting and determining their cell composition. [less ▲]

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See detailForbidden Lines in 6pk (j=1-5) configurations
Biémont, Emile ULg; Quinet, Pascal ULg

in Physica Scripta (1996), 54

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See detailProposition for the acylation mechanism of serine proteases: A one-step process?
Dive, Georges ULg; Dehareng, Dominique ULg; Peeters, Daniel

in International Journal of Quantum Chemistry (1996), 58(1), 85-107

This work proposes a very detailed ab initio study of the hypothesis for a one-step serine protease acylation process with one water molecule acting as the main catalyst reactant. For the 11 increasing ... [more ▼]

This work proposes a very detailed ab initio study of the hypothesis for a one-step serine protease acylation process with one water molecule acting as the main catalyst reactant. For the 11 increasing complexity models considered, the minimum and transition state conformations for the reaction are determined by full geometry optimizations at the ab initio self-consistent field (scF) levels within several basis sets, from MINI-1 to 6-31G, and, for the smallest complexes, at the post-SCF MP2 level within the 6-31G** basis set. The related thermodynamical quantities are calculated for all the conformations. The influence of the oxyanion hole stabilizer and of the dyad His57-Asp102 is quantified and a very good agreement is obtained with point mutagenesis. The activation barrier is found in the range 15-18 kcal/mol. (C) 1996 John Wiley & Sons, Inc. [less ▲]

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See detailDNA bending by the silencer protein NeP1 is modulated by TR and RXR.
Arnold, R.; Burcin, M.; Kaiser, Bruno ULg et al

in Nucleic Acids Research (1996), 24(14), 2640-7

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing ... [more ▼]

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing mechanism acting independently of the relative promoter position. Here we show that NeP1 alone can induce a significant directed bend on DNA. The chicken homologue of human NeP1, CTCF, shows identical binding and bending properties. In contrast, the isolated DNA binding domain of CTCF efficiently binds DNA, but fails to confer bending. Similarly, the TR-RXR hetero- or homodimer, binding adjacent to NeP1 at the F2 sequence, do not show significant DNA bending. The binding of the T3 ligand to TR changes neither the magnitude nor the direction of the NeP1 induced bend. However, when all factors are bound simultaneously as a quaternary complex, the TR-RXR heterodimer changes the location of the bend center, the flexure angle and the bending direction. [less ▲]

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See detailCosmological formation of low-mass objects
Haiman, Z.; Thoul, Anne ULg; Loeb, A.

in Astrophysical Journal (1996), 464(2), 523-538

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks ... [more ▼]

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks starting from the linear perturbative regime. The initial parameters correspond to density peaks of various widths and heights in a cold dark matter cosmology. We use a one-dimensional spherical Lagrangian hydrodynamics code to follow the dynamical, thermal, and nonequilibrium chemical evolution of the gas. The system includes a collisionless dark matter component and a baryonic component composed of the nine species H, H-, H+, He, He+, He++, H-2, H-2(+), and e(-). All relevant chemical reactions between these species and their cooling mechanisms are included in the calculations. We explore the dependence of the dynamical evolution of the gas on two parameters: the initial mass scale and the initial overdensity of the system. We follow the evolution of the density, temperature, and abundance profiles within the cloud, assuming two types of central boundary conditions for the collisionless component: in one the infalling dark matter virializes through a reflection from a hard sphere, while in the other it accretes onto a central sink. We find that in both cases, radiative cooling by H-2 affects the collapse dynamics of the gas only after it has already virialized and become part of the bound object. Therefore, radiative cooling is unlikely to have triggered the initial collapse of perturbations at redshifts z>10. Nevertheless, baryonic objects with masses well below the linear theory Jeans mass (less than or similar to 10(3) M.) form at high redshifts because of shell crossing by the dark matter. Such objects could be the progenitors of a primordial population of high-mass stars in the intergalactic medium. [less ▲]

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See detailPhénologie et domaine vital de la salamandre terrestre Salamandra salamandra terrestris (Amphibia, Caudata) dans un bois du Pays de Herve (Belgique)
Denoël, Mathieu ULg

in Cahiers d'Ethologie (1996), 16

The aim of this study was to approach some aspects of the life-history of the fire salamander Salamandra s. terrestris in a small wood of the Vesdre Valley (Liege Province, Belgium). In 1996, 189 ... [more ▼]

The aim of this study was to approach some aspects of the life-history of the fire salamander Salamandra s. terrestris in a small wood of the Vesdre Valley (Liege Province, Belgium). In 1996, 189 salamanders were marked and 68 recaptured. Their cartographic position and the meteorological conditions were noted. Salamanders were active from March to October, mated from May to August and females gave birth to larvae in March-April. Only a small part of the population was active at the same moment. Salamanders were generally faithful to a home range, in spite of some erratic individuals, and are apparently non-territorial. They moved principally along a path. The population is important but strongly threatened by the perturbation of its environment: stream drying, clearing and forest fire. [less ▲]

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See detailFibres alimentaires chez le chien : I. Définition et composition chimique
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1996), 140

The present paper is the first part of a review on dietary fibres. Dietary fibres, frequently used in humans, are at present proposed to be incorporated in feed for pets. Definitions, types of fibres and ... [more ▼]

The present paper is the first part of a review on dietary fibres. Dietary fibres, frequently used in humans, are at present proposed to be incorporated in feed for pets. Definitions, types of fibres and the principal chemical constituents are described along with the potential applications in the agro-industry and therapy. [less ▲]

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See detailAnaesthesia for cardiac surgery
Larbuisson, Robert ULg; Lamy, Maurice ULg

in Current Opinion in Anaesthesiology (1996), 9

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See detailMaladie de Hodgkin et facteurs de croissance
Fillet, Georges ULg

in Tempo Médical (1996), 166

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See detailRole of the metallothioneins in metal regulation by the guillemot Uria aalge
Bouquegneau, Jean-Marie ULg; Debacker, Virginie ULg; Gobert, Sylvie ULg et al

in Comparative Biochemistry and Physiology. C : Comparative Pharmacology and Toxicology (1996), 113C(2), 135-139

Guillemots, like other seabird species living in the North Sea, appear to be heavily contaminated by copper. Metallothioneins are present in both liver and kidney but, at least in the specimens stranded ... [more ▼]

Guillemots, like other seabird species living in the North Sea, appear to be heavily contaminated by copper. Metallothioneins are present in both liver and kidney but, at least in the specimens stranded along the Belgian coast, fail to maintain constant the copper, zinc and cadmium load of the high molecular weight soluble proteins of both organs, stressing the potential toxic role of these metals, mainly copper. [less ▲]

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See detailLessons from the discovery of leptin: is obesity an endocrine disease?
Scheen, André ULg

in Acta Clinica Belgica (1996), 51(6), 371-6

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See detailA computer controlled PIGE setup for the analysis of thin samples
Strivay, David ULg; Garnir, Henri-Pierre ULg; Weber, Georges

in Nuclear Instruments & Methods in Physics Research Section B (1996), 113(1-4), 407-410

A computer controlled PIGE setup has been improved by adding a beam energy disperser which whips out most of the structure of the proton excitation functions and allows better analysis of thin samples.

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See detailEvolution des directions et des vitesses des vents de 1951 à 1994 sur la façade Atlantique de l’Afrique de l’Ouest du sud du Sénégal au nord de la Mauritanie.
Ozer, Pierre ULg

in Publications de l'Association Internationale de Climatologie (1996), 9

The Sahel is affected by a severe drought since the late 1960s. This paper analyses the potential fluctuations of wind on a 44-year period (1951-1994) on the Atlantic coast of West Africa. The change in ... [more ▼]

The Sahel is affected by a severe drought since the late 1960s. This paper analyses the potential fluctuations of wind on a 44-year period (1951-1994) on the Atlantic coast of West Africa. The change in wind direction could be a witness of a modification on a synoptic scale. The wind velocity recorded in four meteorological stations does not show any rise which could be linked with a continuous aridification. [less ▲]

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See detailRéactions physiologiques face à des conditions extrêmes de chaleur et d'humidité relative: Etude des effets de l'exercice
Art, Tatiana ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (1996), 28

The purpose of this study was to investigate the effect of a hot and humid environment on the pattern of breathing and the gas exchange in heavily exercising horses. Five healthy fit standardbred horses ... [more ▼]

The purpose of this study was to investigate the effect of a hot and humid environment on the pattern of breathing and the gas exchange in heavily exercising horses. Five healthy fit standardbred horses (493± 14 kg; 4± 0,5yrs) were investigated twice at eight days interval, once in temperated atmos¬pheric conditions (TC) (ambient temperature : 15o C; relative humidity : 55 %) and once in hot and humid conditions (HHC) (ambient temperature : 30°C; relative humidity : 75 %). The standardized treadmill exercise test consisted in 8 min warm-up and in 8 min exer¬cise (1 min at 1,7, 4, 7, 8, 9 and 10 m/sec and 2 min at 4 m/sec with a 6% slope). Respiratory airflow, tidal volume, respiratory frequency as well as the 02 and C02 fraction in the inspired and expired gases were continuously recorded, using 2 ultrasonic pneumo¬tachographs connected to a face mask and a mass spectrometer. Oxygen uptake (VO2, carbon dioxide output (VCO2,), respiratory quotient (RQ) and expired minute volume (VE.) as well as alveolar partial pressure in C02 (PAC02) were obtained on a breath-by--breath basis. The maximal values obtained during the highest intensity were used for the comparison between both tests. Heart rate and skip temperature were continuously recorded, using a heart rate recording system and a real time infrared thermographic unit, respecti¬vely. Venous blood was sampled before and 2 min after the completion of the test for hematological and biochemical analysis, namely plasma lactate (LA), beta-endorphins, cortisol (Cor). Running in HHC induced a significant decrease in peak VE, VO2, VCO2 and oxygen pulse, while RQ remained unchanged and PAC02 increased. The changes in skin temperature (ST), i.e. the difference between ST at rest and at 10 m/sec, was dramatically higher in HHC. As well, the test-induced changes, i.e. the differences between the values before and after the test, in Cor, beta-endorphins and LA values after the test were significantly higher. This study shows that performing a strenuous exercise in hot, humid conditions in unacclimatized horses induced a reduction of the aerobic capacity, i.e. decrease of the VO2 and increase of LA production. A relative hypoventilation could be partly responsible for this observation, but all the steps of the oxygen transport from the pulmonary ventilation to the muscle metabolism could also potentially be impaired in such conditions [less ▲]

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See detailThe influence of follicular dendritic cells on B-cell proliferation depends on the activation of B cells and the mitogen used.
Bosseloir, A.; Bouzahzah, F.; Defrance, T. H. et al

in Scandinavian Journal of Immunology (1996), 43(1), 23-30

Follicular dendritic cells (FDC) are unique non-lymphoid cells found only in lymph follicles. They play a part in the survival, proliferation and differentiation of B cells. To analyse the influence of ... [more ▼]

Follicular dendritic cells (FDC) are unique non-lymphoid cells found only in lymph follicles. They play a part in the survival, proliferation and differentiation of B cells. To analyse the influence of FDC on B-lymphocyte proliferation, we isolated them from human tonsils on albumin gradients and treated them with mitomycin C to prevent the multiplication of lymphoid cells harboured in their cytoplasmic evaginations. FDC cultured for 12-16 h remained attached to the substrate; non-adherent cells were carefully eliminated by washing. Purified B cells cultured alone or with contaminant-cleared FDC were maintained for 2 days in the presence or absence of various stimulants, after which tritiated thymidine uptake by these cells was measured. In the absence of activators, FDC did not induce B-cell multiplication. B cells cultured in the presence of FDC exhibited increased 3H-TdR uptake when activated with anti-CD40 MoAb, anti-immunoglobulin MoAb or transferrin, but not when stimulated with Staphylococcus aureus strain Cowan I (SAC) at a given concentration. In the latter case, B-cell proliferation clearly decreased. In control cocultures where mitomycin-C-treated non-adherent cells were used instead of FDC in the presence of the different stimulants, no increase in B-cell proliferation was observed. The results suggest that, inside the germinal centres, FDC modulation of B-cell proliferation depends on the activation state of the B cells and on the stimulant encountered. [less ▲]

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See detailMicroscopic observation of the retinal photoreceptor layer of the common barbel (Teleostei: Cyprinidae)
Compère, Philippe ULg; Poncin, Pascal ULg

in Belgian Journal Of Zoology (1996), 126(1), 49-56

Light and electron microscopic observations show that cones-belonging to four types are present in the retina of the common barbel Barbus barbus (L.): short single cones, long single cones, twin cones ... [more ▼]

Light and electron microscopic observations show that cones-belonging to four types are present in the retina of the common barbel Barbus barbus (L.): short single cones, long single cones, twin cones, and unequal double cones. They do not exhibit any particular arrangement. Estimates of cone density suggest that the common barbel has multichromatic vision but of low acuity and that no difference exists between the lower and the upper parts of the retina. Both cone density (approximately 3000 units/mm(2)) and the proportion of double cones to single cones (approximately 1:3) are low. The view that the barbel has an inferior colour vision is in good agreement with the fact that this species is active mainly at twilight, but with diurnal activity during spawning. [less ▲]

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See detailMaurice Streel, an annotated list of his publications.
Steemans, Philippe ULg; Loboziak, S

in Annales de la Société Géologique de Belgique (1996), 117

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See detailInsulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells.
l'Allemand, D.; Penhoat, A.; LEBRETHON, Marie-Christine ULg et al

in The Journal of clinical endocrinology and metabolism (1996), 81(11), 3892-7

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation ... [more ▼]

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation. In the present study, we examined the long term effects of IGF-I and -II on human adult adrenal fasciculata-reticularis cells cultured in a chemically defined medium and compared them to the effects of insulin, human GH, and ACTH. Treatment for 3 days with IGF-I or -II at nanomolar concentrations or with insulin at micromolar concentrations slightly increased the production of androstenedione, cortisol, and dehydroepiandrosterone about 1.5-fold over that by control cells. Moreover, the acute steroidogenic response to ACTH of cells pretreated with IGF-I, IGF-II, or insulin was 3- to 6-fold higher than that of control cells. For each hormone, these effects of IGF-I and -II were dose dependent between 0.1-26 nmol/L (1-200 ng/mL). The secretion of androstenedione was more potently stimulated than that of dehydroepiandrosterone and cortisol, and this effect was more clearly yielded by pretreatment with IGF-II than with IGF-I or insulin. Human GH had no effect on these cells. In cells treated with IGF-I or -II, the messenger ribonucleic acid (mRNA) levels of cytochrome P450 17 alpha-hydroxylase and of 3 beta-hydroxysteroid dehydrogenase were increased, and the abundance of ACTH receptor mRNA was also slightly enhanced, but the mRNA of cytochrome P450 cholesterol side-chain cleavage enzyme was unchanged. In conclusion, IGFs enhance the steroidogenesis and ACTH responsiveness of human adrenocortical cells in culture. We speculate, that by this mechanism, IGFs may contribute to clinical states with hyperandrogenemia. [less ▲]

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See detailExpression of the Mr 67,000 laminin receptor is an adverse prognostic indicator in human thyroid cancer: an immunohistochemical study.
Basolo, F.; Pollina, L.; Pacini, F. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1996), 2(10), 1777-80

Increased expression of the Mr 67,000 laminin receptor (LR) is a consistent event which appears as cancer cells acquire an invasive and metastatic phenotype. The Mr 67,000 LR is one of the many laminin ... [more ▼]

Increased expression of the Mr 67,000 laminin receptor (LR) is a consistent event which appears as cancer cells acquire an invasive and metastatic phenotype. The Mr 67,000 LR is one of the many laminin-binding proteins able to interact with the major glycoprotein of basement membranes, laminin. The recent development of a specific monoclonal antibody directed against the Mr 67,000 LR MLuC5 has allowed us to study large retrospective groups of human cancers with the aim of correlating the Mr 67,000 LR expression to the clinical, pathological, and survival data of the patients. A significant correlation has already been established between the increased expression of Mr 67,000 LR and survival of patients with breast, colon, ovary, lung, and endometrial cancers. In this study, we investigated the possibility that the detection of Mr 67,000 LR in thyroid human cancers could also be of prognostic value. We analyzed the expression of Mr 67,000 LR with immunohistochemistry using MLuC5 antibodies in paraffin sections of 40 benign and 170 malignant thyroid human tumors. We found that Mr 67,000 LR was not usually detectable in normal thyroid tissues adjacent to the lesion. Only 3 of the 40 thyroid adenomas examined (7.5%) presented cells positive for Mr 67,000 LR. For the malignant thyroid tumors examined, we found that 22.3% of papillary thyroid carcinomas, 38% of follicular thyroid carcinomas, 40% of poorly differentiated carcinomas, 25% of medullary carcinomas, and 58.3% of anaplastic carcinomas expressed a high level of Mr 67,000 LR. Although no correlation between the Mr 67,000 LR expression and survival was found in patients with follicular thyroid carcinomas, papillary thyroid carcinomas, anaplastic carcinomas, and medullary carcinomas, there was a significant correlation in primary thyroid cancers. Our data represent the first extensive study of the Mr 67,000 LR expression in human thyroid cancers and strongly suggest that its detection could be of prognostic value in the investigation of primary thyroid cancers. [less ▲]

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See detailCase management voor psychogeriatrishe patiënten: de case manager
Borgermans, L.; Milisen, K.; Dejace, Alain ULg et al

in Acta Hospitalia (1996), 4

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See detailFusogenic Properties Of The C-Terminal Domain Of The Alzheimer Beta-Amyloid Peptide
Pillot, T.; Goethals, M.; Vanloo, B. et al

in Journal of Biological Chemistry (1996), 271(46), 28757-65

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was ... [more ▼]

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was investigated. These peptide domains were identified by computer modeling and correspond to respectively the C-terminal (e.g. residues 29-40 and 29-42) and a central domain (13-28) of the beta-amyloid peptide. The C-terminal peptides are predicted to insert in an oblique way into a lipid membrane through their N-terminal end, while the mutants are either parallel or perpendicular to the lipid bilayer. Peptide-induced vesicle fusion was demonstrated by several techniques, including lipid-mixing and core-mixing assays using pyrene-labeled vesicles. The effect of peptide elongation toward the N-terminal end of the entire beta-amyloid peptide was also investigated. Peptides corresponding to residues 22-42 and 12-42 were tested using the same techniques. Both the 29-40 and 29-42 beta-amyloid peptides were able to induce fusion of unilamellar lipid vesicles and calcein leakage, and the amyloid 29-42 peptide was the most potent fusogenic peptide. Neither the two mutants or the 13-28 beta-amyloid peptide had any fusogenic activity. Circular dichroism measurements showed an increase of the alpha-helical content of the two C-terminal peptides at increasing concentrations of trifluoroethanol, which was accompanied by an increase of the fusogenic potential of the peptides. Our data suggest that the alpha-helical content and the angle of insertion of the peptide into a lipid bilayer are critical for the fusogenic activity of the C-terminal domain of the amyloid peptide. The differences observed between the fusogenic capacity of the amyloid 29-40 and 29-42 peptides might result from differences in the degree of penetration of the peptides into the membrane and the resulting membrane destabilization. The longer peptides, residues 22-42 and 12-42, had decreased, but significant, fusogenic properties associated with perturbation of the membrane permeability. These data suggest that the fusogenic properties of the C-terminal domain of the beta-amyloid peptide might contribute to the cytotoxicity of the peptide by destabilizing the cell membrane. [less ▲]

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See detailThe seasonality of the CO2 exchange between the atmosphere and the land biosphere: A study with a global mechanistic vegetation model
Nemry, B.; François, Louis ULg; Warnant, Pierre ULg et al

in Journal of Geophysical Research (1996), 101(D3), 7111-7125

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR ... [more ▼]

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR), and a mechanistic model of carbon assimilation in the biosphere (CARAIB) that estimates the net primary production (NPP) of continental vegetation. The steady state hypothesis of the biosphere allows the spatial distribution and the global content of the soil carbon to be expressed as a function of the root fractions of soil respiration under forested and herbaceous vegetation covers. The sensitivity of the modeled CO2 signal to the wind field does not exceed the observed interannual variability. The influence of the various vegetation zones is quantified by the Fourier analysis of the modeled atmospheric signal. In the northern hemisphere, the temperate ecosystems dominate the seasonal atmospheric signal of the extratropical latitudes. The ecosystems of the tropical northern zone determine the local signal, while the southern tropical ecosystems influence largely the signal in the whole southern hemisphere. The results give credence to the mechanistic modeling of NPP since the simulated atmospheric signal is comparable with that obtained with normalized difference vegetation index (NDVI) based diagnostic models coupled with a parameterization of SHR fitted to optimize the atmospheric signal. [less ▲]

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See detailCodon adjustment to maximise heterologous gene expression in Streptomyces lividans can lead to decreased mRNA stability and protein yield.
Lammertyn, E; Van Mellaert, L; Bijnens, A P et al

in Molecular & General Genetics [=MGG] (1996), 250(2), 223-9

The impact of the codon bias of the mouse tumour necrosis factor alpha (mTNF) gene cloned in Streptomyces lividans on the efficiency of expression and secretion was analysed. Minor codons occurring in the ... [more ▼]

The impact of the codon bias of the mouse tumour necrosis factor alpha (mTNF) gene cloned in Streptomyces lividans on the efficiency of expression and secretion was analysed. Minor codons occurring in the mTNF gene were therefore adapted to the codon bias of Streptomyces by site-directed mutagenesis. No improvement in mTNF yield could be detected. The stability of the transcript derived from the construct was shown to be more important for determining the final level of mTNF production. A strong correlation was observed between the yield of secreted biologically active mTNF and the amount of mTNF mRNA present in the cells. [less ▲]

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See detailGranuloma tuberculoide post-herpético en un paciente con leucemia linfocítica crónica
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Medicina Cutanea Ibero-Latino-Americana (1996), 24

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See detailCarotid Surgery in Octogenarians: Is It Worthwhile?
VAN DAMME, Hendrik ULg; Lacroix; Desiron, Quentin ULg et al

in Acta Chirurgica Belgica (1996), 96(2), 71-7

Controversy surrounds the role of carotid endarterectomy in octogenarians. Although the prognosis of severe degree carotid stenosis is more ominous in the elderly, operative risk seems more important in ... [more ▼]

Controversy surrounds the role of carotid endarterectomy in octogenarians. Although the prognosis of severe degree carotid stenosis is more ominous in the elderly, operative risk seems more important in the aged. To evaluate the presumed detrimental effect of advanced age on the mortality-morbidity of carotid endarterectomy, the authors reviewed their common experience with carotid surgery in patients aged 80 years or more. From 1980 to 1994, 129 octogenarians were operated on for occlusive carotid artery disease in two university hospitals. The data for these patients, 80 years of age and older (group 1) are compared to these for a large middle age group (less than 80 years) (group 2) operated by the same surgeons during that period. The baseline characteristics of both groups were similar, except for smoking, diabetes and previous myocardial revascularization, more prevalent in the younger age group. In the elderly group prophylactic surgery for asymptomatic stenosis was done in 36%, versus 40% of the middle aged patients, and for stroke in evolution in 8% versus 4% (p < 0.05). The perioperative stroke rate was 0.8% in the group older than 80 years, compared to 1.2% for non octogenarians (NS). The operative mortality was similar for both age groups (2.3 and 1.5 respectively). The long-term results gave a similar outlook for both age groups. The 5-year stroke-free rate reached 89% for group 1 versus 91% for group 2. The 5-year survival rate, however, was less for the elderly patients (47% versus 77%, mean follow-up periods of 30 and 49 months). These results suggest that carotid endarterectomy can be safely done in elderly patients, with a similar risk/benefit ratio as for the younger patients. Advanced age, by itself, is not to be considered as contraindication to carotid surgery. [less ▲]

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See detailCase management voor psychogeriatrishe patiënten: theoritisch kader van een verpleegkundig demonstratieproject
Borgermans, L.; Milisen, K.; Dejace, Alain ULg et al

in Acta Hospitalia (1996), 4

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See detailImmunoreactive levels of α-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1
Mastrogiacomo, Frank; LaMarche, Jacques; Dozic, Slobodan et al

in Neurodegeneration : A Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration (1996), 5

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See detailYounger age as a bad prognostic factor in patients with carcinoma of the cervix.
Delaloye, J-F; Pampallona, S; COUCKE, Philippe ULg et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (1996)

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre ... [more ▼]

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre Hospitalier Universitaire Vaudois of Lausanne were subdivided according to the following age categories: _<45, 46-60, 61-69 and > 70 years. Taking the 46-60 years age group as the reference, the hazard ratios (HR) of death and corresponding 95% confidence intervals (95% CI) were estimated by means of a Cox multivariate analysis. Results: The 5-year survival rates were, respectively, 57%, 67%, 60% and 45%. For the youngest women the risk of death was significantly increased (HR = 2.00, 95% CI [1.32-3.00]) and was even more accentuated in advanced stages. Conclusion: Age under 45 years is a bad prognostic factor in carcinoma of the cervix. [less ▲]

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See detailMechanism of Single-Electron Capture by the Dichlorocarbene Dication.
Leyh, Bernard ULg; Hautot, D.

in Journal of the American Society for Mass Spectrometry (1996), 7

The single-electron capture (SEC) by dichlorocarbene with eight different atomic and molecular target gases, (CCl2)2++G->(CCl2)++G+, has been studied by product ion spectroscopy and ion kinetic energy ... [more ▼]

The single-electron capture (SEC) by dichlorocarbene with eight different atomic and molecular target gases, (CCl2)2++G->(CCl2)++G+, has been studied by product ion spectroscopy and ion kinetic energy spectroscopy. The experimental data have been interpreted in the framework of a theoretical model that describes the charge exchange process. Exothermic charge exchange is handled within the Landau-Zener model, whereas endothermic charge exchange is described by the Demkov model. The calculated data reproduce qualitatively the essential features of the experimental results: (1) the appearance of a reaction window centered at an exothermicity in the 4-4.5 eV range, (2) the lower SEC cross sections for endothermic charge exchange, (3) the wider internal energy distributions obtained for CCl2+ in the endothermic regime than in the exothermic one, which results in larger dissociation yields, (4) the excitation of molecular targets that accompany their ionization in the SEC process, and (5) the kinetic energy released on the CCl++Cl fragments in dissociative SEC. [less ▲]

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See detailActivités sportives et système immunitaire
PIRNAY, Freddy ULg; Bury, Thierry ULg

in Médecine et Hygiène (1996), 54

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See detailAssesment of nuclear totipotency of fetal bovine diploid germ cells by nuclear transfer
Moens, André; Chesné, Patrick; Delhaize, Françoise et al

in Theriogenology (1996), 46

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See detailOscillator strengths for Ca-like iron, cobalt and nickel (Fe VII, Co VIII, Ni IX)
Quinet, Pascal ULg; Hansen, J E

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailInfluence of thermal acclimation on the survival of Sitophilus granarius (L) and Oryzaephilus surinamensis (L) at low temperatures
Mignon, Jacques ULg; Haubruge, Eric ULg; Gaspar, Charles ULg

in Netherlands Journal of Zoology (1996), 46(3-4), 317-325

Low temperatures have been used for many years to control populations of stored-product insects. The aim of aeration was primarily to cool down the grain and then to prevent its deterioration by reducing ... [more ▼]

Low temperatures have been used for many years to control populations of stored-product insects. The aim of aeration was primarily to cool down the grain and then to prevent its deterioration by reducing the number of insects. In Belgium, the mild winters enable insects to survive to the next season. In autumn, the progressive lowering of temperature has an acclimation effect on stored-product insects. The present study was undertaken to determine the survival at low temperatures of non cold-acclimated and laboratory- and field-cold-acclimated insects. We have chosen to work with the granary weevil Sitophilus granarius (L.) and the saw-toothed grain beetle Oryzaephilus surinamensis (L.). They are the most frequent stored-grain pests in Belgium. To compare the cold-hardiness of different laboratory cold-acclimated insects, S. granarius and O. surinamensis were placed at nine different cold-acclimation temperature regimes. Insects were kept at 5 degrees C for 2, 4 and 6 weeks or at -5 degrees C for 4, 7 and 14 days. To assess the field-cold-acclimation in autumn and in winter, insects were monthly taken from a bin and transferred to 5 degrees C for 6 weeks. S. granarius adults were more cold-hardy than O. surinamensis, but O. surinamensis adults compensated their cold-sensibility by a great ability to acclimate. S. granarius is able to survive the winter in Belgium because of its cold-hardiness while O. surinamensis survives because of its ability to acclimate to low temperatures. [less ▲]

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See detailThe development of a European questionnaire for quality of life in patients with vertebral osteoporosis
Lips, P; Agnusdei, D; Caulin, F et al

in Scandinavian Journal of Rheumatology (1996), 25(103), 84-85

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See detailOverexpression of the 67-kD laminin receptor correlates with tumour progression in human colorectal carcinoma.
Sanjuan, X.; Fernandez, P. L.; Miquel, R. et al

in Journal of Pathology (The) (1996), 179(4), 376-80

The high affinity 67-kD laminin receptor (67LR) is a cell surface protein whose expression is increased in a number of human carcinoma models. To date, 67LR expression in colorectal carcinomas has been ... [more ▼]

The high affinity 67-kD laminin receptor (67LR) is a cell surface protein whose expression is increased in a number of human carcinoma models. To date, 67LR expression in colorectal carcinomas has been examined in a small number of cases. 67LR expression has been immunohistochemically analysed in a large series of human colorectal neoplasms, using the MLuC5 monoclonal antibody. The study included 59 samples of non-neoplastic mucosa, 45 polyps (11 hyperplastic, 34 adenomas), 196 carcinomas, and lymph node metastases of 87 carcinomas. Epithelial cells of normal mucosa and hyperplastic polyps were negative or showed weak positivity in the paranuclear and apical areas of the cytoplasm. In adenomas and carcinomas, the staining was stronger, with a membranous or cytoplasmic pattern. The expression of 67LR correlated significantly with the progression from normal mucosa (22 per cent) to adenoma (44 per cent), carcinoma (61 per cent), and lymph node metastasis (75 per cent) (P < 0.0001). Expression of the laminin receptor showed a tendency to be more frequently positive in advanced stage (III+IV; 67 (III+IV; 67 per cent) when compared with early stage (I+II) carcinomas (54 per cent). The difference, however, was not statistically significant (P = 0.058). In addition, 14 out of 28 (50 per cent) primary carcinomas without 67LR expression became positive in lymph node metastases, while most (86 per cent) of the MLuC5-positive primary carcinomas were also immunoreactive in metastases. In conclusion, these results indicate that 67LR is up-regulated in the progression of human colorectal carcinomas and may play a role in the local and metastatic progression of these tumours. [less ▲]

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See detailRecommendations for the registration of agents used in the prevention and treatment of glucocorticoid-induced osteoporosis
Compston, JE; Audran, M; Avouac, B et al

in Calcified Tissue International (1996), 59

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See detailPorous biomaterials tailored for cell culture.
Grandfils, Christian ULg; Maquet, V; Ropson, N et al

in Cytotechnology (1996), 21

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See detailIncidence du martelage sur l'exploitation mécanisée des premières éclaircies résineuses
Hebert, Jacques ULg; Lejeune, Philippe ULg; Van Belle, Jean-François et al

in Silva Belgica (1996), 103(6), 7-14

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See detailRadiosensitization in vitro by (E)-2′-(fluoromethylene)-deoxy-cytidine (FMdC), pentoxifylline (PTX) or a combination
Li; COUCKE, Philippe ULg; Paschoud et al

in International Journal of Radiation, Oncology, Biology, Physics (1996), 36(1 (supp1)), 383

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See detailImpairement of Memory for Spatial Context in Schizophrenia
Van der Linden, Martial ULg; Rohmer, J.G.; Rizzo, L. et al

in Neuropsychology (1996), 10

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See detailCongenital psoriasis following the lines of Blaschko.
Lehners-Weber, C.; de LA BRASSINNE, Michel ULg; Dezfoulian, Bita ULg et al

in Pediatric Dermatology (1996), 13(3), 219-221

Congenital psoriasis without an underlying nevus following the lines of Blaschko is described in a 6-year-old girl. In addition to this special type of psoriasis, she suffered from atopic dermatitis. The ... [more ▼]

Congenital psoriasis without an underlying nevus following the lines of Blaschko is described in a 6-year-old girl. In addition to this special type of psoriasis, she suffered from atopic dermatitis. The lesions were aggravated by sun exposure and phototherapy treatments, as well as by upper airways infections, without any clear explanation of these trigger factors. We propose to call this form of psoriasis congenital blaschkoid psoriasis. [less ▲]

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See detailDeffand, Marie de Vichy-Chamrond, marquise du
Tilkin, Françoise ULg

in Voir barré (1996), 12-13

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See detailLa traversée des candiatures universitaires : Une analyse de cas
Beckers, Jacqueline ULg; Boxus, Elise ULg

in Res Academica (1996), 13(1-2), 85-104

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See detailEnergy levels and oscillator strengths for transitions in Pd II
Quinet, Pascal ULg

in Physica Scripta (1996), 54

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See detailPeptide G, containing the binding site of the 67-kDa laminin receptor, increases and stabilizes laminin binding to cancer cells.
Magnifico, A.; Tagliabue, E.; Buto, S. et al

in Journal of Biological Chemistry (1996), 271(49), 31179-84

We investigated the effect of peptide G, a synthetic peptide derived from the sequence of the 37-kDa laminin receptor precursor, on the interaction of laminin in two tumor cell lines one of which produces ... [more ▼]

We investigated the effect of peptide G, a synthetic peptide derived from the sequence of the 37-kDa laminin receptor precursor, on the interaction of laminin in two tumor cell lines one of which produces laminin and one of which does not. Addition of peptide G to the culture medium induced a significant increase in the amount of endogenous laminin detectable on the cell membrane of both cell lines. Moreover, pretreatment of exogenous laminin with peptide G dramatically increased laminin binding on both cell lines. Kinetics analysis of membrane-bound labeled laminin revealed a 3-fold decrease in the kd of peptide G-treated laminin compared with untreated or unrelated or scrambled peptide-treated laminin. Moreover, the affinity constant of peptide G-treated laminin increased 2-fold, with a doubling of the number of laminin binding sites, as determined by Scatchard analysis. Expression of the VLA6 integrin receptor on the cell membrane increased after incubation with peptide G-treated laminin. However, the lower binding inhibition of peptide G-treated laminin after anti-VLA6 antibody or cation chelation treatment indicates that membrane molecules in addition to integrin receptors are involved in the recognition of peptide G-modified laminin. These "new" laminin-binding proteins also mediated cell adhesion to laminin, the first step in tumor invasion. Together, the data suggest that peptide G increases and stabilizes laminin binding on tumor cells, involving surface receptors that normally do not take part in this interaction. This might explain the abundant clinical and experimental data suggesting a key role for the 67-kDa laminin receptor in the interaction between cancer cells and the basement membrane glycoprotein laminin during tumor invasion and metastasis. [less ▲]

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See detailA comprehensive pollen- and tephra- based chronostratigraphic model for the Late Glacial and Holocene Period in the French Massif Central.
Juvigné, Etienne ULg; Bastin, B; Delibrias, G et al

in Quaternary International (1996), 34-36

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See detailInfections oculaires traumatiques et iatrogènes: prélèvements et rôle du laboratoire
Melin, Pierrette ULg

in Bulletin de la Société Belge d'Ophtalmologie (1996), 260

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological ... [more ▼]

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological diagnostic. The indications and techniques for investigations are determined by the site of infection, severity of the process, and knowledge of the likely responsible organisms. Immediate inoculation of specimens on culture media in the examining room is often recommended. This article describes organisms associated with ocular infections, and is designed to assists ophthalmologists in the collection, processing and transport of specimens. [less ▲]

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See detailCalcitonin
Reginster, Jean-Yves ULg

in Current Opinion in Orthopaedics (1996), 7

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See detail8-Chloro-5-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,5]benzodiazepine
Dupont, L.; Liégeois, Jean-François ULg; Rogister, F. et al

in Acta Crystallographica Section C-Crystal Structure Communications (1996), C52

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See detailIntestinal Permeability in Crohn's Disease
Franchimont, D.; Louis, Edouard ULg; Simon, Sarah ULg et al

in Acta Gastro-Enterologica Belgica (1996), 59(1, Jan-Mar), 15-9

We summarize the anatomical and physiological basis and the ways of measuring the intestinal permeability. We review the studies of the intestinal permeability in Crohn's disease. We analyse the ... [more ▼]

We summarize the anatomical and physiological basis and the ways of measuring the intestinal permeability. We review the studies of the intestinal permeability in Crohn's disease. We analyse the involvement of an abnormal intestinal permeability in the pathogenesis of Crohn's disease, as a primary or secondary defect. We discuss the potential usefulness of the measure of intestinal permeability in Crohn's disease activity assessment, relapse prediction and efficacy of treatment. [less ▲]

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See detailAssureurs et prédations: Les développements de l'assurance contre le vol en France
Lemaître, André ULg

in Les Cahiers de la Sécurité Intérieure (1996), N°25

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See detailOne-pot enzymatic synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc sequence with in situ UDP-Gal regeneration.
Hokke, Cornelis H; Zervosen, Astrid ULg; Elling, Lothar et al

in Glycoconjugate Journal (1996), 13(4), 687-92

The trisaccharide Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was enzymatically synthesized, with in situ UDP-Gal regeneration. By combination in one pot of only four enzymes, namely ... [more ▼]

The trisaccharide Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was enzymatically synthesized, with in situ UDP-Gal regeneration. By combination in one pot of only four enzymes, namely, sucrose synthase, UDP-Glc 4'-epimerase, UDP-Gal:GlcNAc beta 4-galactosyltransferase and UDP-Gal:Gal beta 1-->4GlcNAc alpha 3-galactosyltransferase, Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was formed in a 2.2 mumol ml-1 yield starting from the acceptor GlcNAc beta 1-->O-(CH2)8COOCH3. This is an efficient and convenient method for the synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc epitope which pays an important role in various biological and immunological processes. [less ▲]

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See detailSpontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome.
Beguin, Yves ULg; Collignon, Jacques ULg; Laurent, C. et al

in British Journal of Haematology (1996), 94(3), 507-9

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a ... [more ▼]

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a relapse of his MDS with complete disappearance of donor haemopoiesis. After two episodes of CMV pneumonia and continued prophylactic use of ganciclovir thereafter, he experienced a spontaneous complete disappearance of all signs of MDS, including myelofibrosis, and a complete return to donor haemopoiesis. This case is the first one to suggest a graft-versus-leukaemia effect (GVL) in MDS patients. It depicts the complex relationship between GVL, graft-versus-host disease (GVHD) and graft rejection. It could also constitute a clinical illustration of the possible antileukaemic effect of CMV infection and its treatment with ganciclovir. [less ▲]

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See detailStorm surges in the Arabian/Persian Gulf
Djenidi, Salim ULg; Neuberg, Luc

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailComment les professeurs de mathématiques évaluent-ils leurs élèves ?
Demonty, Isabelle ULg; Detheux-Jehin, M.; Vlassis, Joëlle ULg

in Informations Pédagogiques (1996), 27

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See detailA New Equilibrium Cell with Variable Cell Volume for Static Vapour-Pressure Measurements
Gaube, J; Hammer, S; Pfennig, Andreas ULg

in Fluid Phase Equilibria (1996), 123((1-2)), 245-257

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See detailLe vétérinaire et la qualité microbiologique des denrées alimentaires d’origine animale
Vindevogel, Henri ULg; Daube, Georges ULg; Denys, Jacques et al

in Annales de Médecine Vétérinaire (1996), 141

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See detailPremière approche de la flore macrolichénique corticole de la Région de Bruxelles-Capitale en situation de dépollution au SO2
Tanghe, Martin; Richel, Thierry; Crisan, Florin et al

in Belgian Journal of Botany (1996), 129

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See detailNew isozymes markers for the study of the gene pool Phaseolus lunatus L.
Zoro Bi, Irié; Maquet, Alain; Wathelet, Bernard ULg et al

in Annual Report of the Bean Improvment Cooperative (1996), 39

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See detailHeparin-coated Palmaz-Schatz stents in human coronary arteries. Early outcome of the Benestent-II Pilot Study.
Serruys, P. W.; Emanuelsson, H.; van der Giessen, W. et al

in Circulation (1996), 93(3), 412-22

BACKGROUND: The purpose of the Benestent-II Pilot Study was to evaluate the safety of delaying and eliminating anticoagulant therapy in patients receiving a heparin-coated stent in conjunction with ... [more ▼]

BACKGROUND: The purpose of the Benestent-II Pilot Study was to evaluate the safety of delaying and eliminating anticoagulant therapy in patients receiving a heparin-coated stent in conjunction with antiplatelet drugs. METHODS AND RESULTS: The study consisted of three initial phases (I, II, III) during which resumption of heparin therapy after sheath removal was progressively deferred by 6, 12, and 36 hours. In phase IV, coumadin and heparin were replaced by 250 mg ticlopidine and 100 mg aspirin. Of the 207 patients with stable angina pectoris and a de novo lesion in whom heparin-coated stent implantation was attempted, implantation was successful in 202 patients (98%). Stent thrombosis did not occur during all four phases, and the overall clinical success rate at discharge was 99%. Bleeding complications requiring blood transfusion or surgery fell from 7.9% in phase I to 5.9%, 4%, and 0% in the three following phases. Hospital stay was 7.4, 6.1, 7.2, and 3.1 days for the consecutive phases. The restenosis rate for the combined four phases was 13% (15% in phase I, 20% in phase II, 11% in phase III, and 6% in phase IV). The overall rate of reintervention for the four phases was 8.9%. At 6 months, 84%, 75%, 94%, and 92% of the patients of phases I to IV, respectively, were event free. For the four phases, the event-free rate was 86%, which compares favorably with the rate observed in the Benestent-I study (80%; relative risk, 0.68 [0.45 to 1.04]). CONCLUSIONS: The implantation of stents coated with polyamine and end-point-attached heparin in stable patients with one significant de novo coronary lesion is well tolerated, is associated with no (sub)acute stent thrombosis, and results in a favorable event-free survival after 6 months. [less ▲]

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See detailGrowth hormone response to apomorphine in obsessive-compulsive disorder.
Pitchot, William ULg; Hansenne, Michel ULg; Moreno, A. G. et al

in Journal of Psychiatry & Neuroscience [=JPN] (1996), 21(5), 343-5

Several lines of evidence suggest that dopamine plays a role in the pathophysiology of obsessive-compulsive disorder (OCD). Indeed, some trials have shown the efficacy of neuroleptic addition in the ... [more ▼]

Several lines of evidence suggest that dopamine plays a role in the pathophysiology of obsessive-compulsive disorder (OCD). Indeed, some trials have shown the efficacy of neuroleptic addition in the treatment of OCD patients. In this study, we assessed the growth hormone (GH) response to 0.5 mg apomorphine(sc) in 8 drug-free inpatients (6 male, 2 female; mean age +/- SD = 34.7 +/- 12.6) meeting DSM-III-R criteria for OCD without major depression and compared their responses with those of 8 healthy male volunteers (mean age = 27.1 +/- 8.5). The groups did not differ in their mean GH peak response: 12.4 +/- 9.7 ng/mL in OCD patients versus 21.1 +/- 14.2 ng/mL in normal controls (F = 0.9, df1, 14, P = 0.37). These results do not support the hypothesis of dopaminergic overactivity in OCD. In fact, the completely blunted GH response to apomorphine in 2 OCD patients suggests the biological heterogeneity of OCD. Some dopaminergic disturbances could be observed in patients with comorbid diagnoses or patients unresponsive to serotonin reuptake inhibitors, but the results of this study require confirmation from a larger sample with a precise assessment of comorbidity. [less ▲]

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See detailChronic Exposure of Pigs to Airborne Dust and Endotoxins in an Environmental Chamber: Technical Note
Urbain, B.; Prouvost, J. F.; Beerens, Dominique ULg et al

in Veterinary Research (1996), 27(6), 569-578

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were ... [more ▼]

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were evaluated in a chamber containing two pigs of 10 kg body-weight: inhalable and respirable dust gravimetric concentrations were measured using area samplers and expressed as mg/m3. The respirable dust concentration was also measured using a "TM digital microP respirable dust-measuring instrument', which has been shown to give similar results to the gravimetric method. The endotoxin concentration was evaluated using the Limulus-assay and expressed as ng/m3 of air containing the inhalable or respirable dust or as ng/mg of inhalable and respirable dust. Feed flour dust was introduced into the chamber to obtain different concentrations of inhalable and respirable dust ranging from 3.62 to 76.66 mg/m3 and from 0.24 to 1.40 mg/m3, respectively. The endotoxin concentration was modulated by mixing the feed flour with Escherichia coli endotoxins before blowing it into the chamber. The endotoxin concentrations in the air containing inhalable or respirable dust ranged from 28.9 to 270.0 ng/m3 and from 2.22 to 36.38 ng/m3, respectively, depending on the amount of endotoxins added to the dust. Data were also obtained in a piggery. The experimental setup detailed in this paper could be used to study the significance of air contaminants in the development of pig respiratory diseases. [less ▲]

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See detailLe fonctionnement de la mémoire à court terme auditive-vocale dans le syndrome de Down : Implications pour le modèle de mémoire de travail
Comblain, Annick ULg

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (1996), 8(4-5), 137-147

Since the end of the sixties, number of studies have put in obviousness that the short-term memory span of mentally retarded subjects remains largely below the level expected regarding their mental age ... [more ▼]

Since the end of the sixties, number of studies have put in obviousness that the short-term memory span of mentally retarded subjects remains largely below the level expected regarding their mental age and their chronological age. Mackenzie and Hulme (1987) and Hulme and Mackenzie (1992), for example, showed that verbal short-term memory abilities of mentally retarded subjects do not develop at the same rate than other cognitives aspects. These results provide important information on the development of memory span in those subjects but do not provide information on the functioning of the different components of their verbal short-term memory. We conducted several experiments in order to supply with this deficit and to describe the functioning of the verbal short-term memory in a group of Down's syndrome subjects. Our data put in obviousness the similarity of verbal short-term memory's functioning in Down's syndrome subjects and in normal children (phonological similarity effect and word length effect). The absence of a significant correlation between articulation rate and memory span in Down's syndrome people (like in less than 6 years old normal children, see Gathercole et al., 1993, 1994) leads us to discuss a central point of the working memory model (Baddeley, 1986). [less ▲]

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See detailThe lichen genus Lecanactis and allied genera in Papua New Guinea
Egea, J.M.; Sérusiaux, Emmanuël ULg; Torrente, Pilar

in Mycotaxon (1996), 59

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See detailLes adénomes gonadotropes
Beckers, Albert ULg; Stevenaert, Achille ULg

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1996), 37(4-5), 299-305

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait ... [more ▼]

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait gonadotropes. Étant donné l'absente de symptomatologie spécifique, ils ne sont souvent reconnus que lorsqu'ils sont volumineux, ayant déjà entraîné un syndrome neurologique, une compression du chiasma optique. Dans la plupart des cas il est possible de les identifier grâce aux produits de sécrétion ou encore par méthodes d'immunohistochimie ou encore par la détection de l'ARN messager correspondant aux sous-unités hormonales. Le traitement reste essentiellement neuro-chirurgical (chirurgie trans-sphénoidale) car, dans la plupart des cas, les agonistes dopaminergiques et les analogues agonistes ou antagonistes de GnRH sont inefficaces. [less ▲]

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See detailTransition probabilities for forbidden lines of Fe III
Quinet, Pascal ULg

in Astronomy and Astrophysics. Supplement Series (1996), 116

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See detailSeduzione borghese e cultura dell'artificio. Femmes fatales in Oriani e Chelli
Curreri, Luciano ULg

in Italian Quarterly (1996), 129-130

Detailed reference viewed: 8 (0 ULg)