References of "Article"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailQuelles alternatives aux oestrogènes pour la prévention de l'ostéoporose post-ménopausique ?
Reginster, Jean-Yves ULg

in Lettre du Rhumatologue (La) (1991), 170

Detailed reference viewed: 10 (1 ULg)
Peer Reviewed
See detailCaractéristiques hygrométriques et niveau de pollution de l'air dans 9 locaux en porcherie d'élevage
Debliquy, P.; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1991), 135

Detailed reference viewed: 12 (1 ULg)
Peer Reviewed
See detailNasal salmon calcitonin in prevention of postmenopausal osteoporosis
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Sarlet, N et al

in Revista Clinica Espanola (1991), 188

Detailed reference viewed: 5 (2 ULg)
Full Text
See detailEcologie de la loutre dans le Marais Poitevin III. Variations du régime et tactique alimentaire.
Libois, Roland ULg; Rosoux, René; Delooz, Etienne

in Cahiers d'Ethologie (1991), 11(1), 31-50

During the spring 1988, spraint samples were collected on the banks of 3 watercourses (one river and two canals) crossing the Marais Poitevin. Their general characteristics (flow rate, conductivity ... [more ▼]

During the spring 1988, spraint samples were collected on the banks of 3 watercourses (one river and two canals) crossing the Marais Poitevin. Their general characteristics (flow rate, conductivity, hydrographic regime) are quite different. The fish community of the two canals was sampled by electrofishing and we estimated the relative abundance of the different fish species. After a check of the reliability of our spraint analysis technique (feeding trials with captive otters), we made an estimate of the relative abundance of the prey items in the otters diet and an assessment of the length and of the weight of each individual fish preyed upon. They are indeed very strong length-weight correlations in fish and also close relationships between the length of some skull bones and the total length od a fish. The diet is mostly made up by the eel. It comprises also a great variety of other fish species, nearly all that were observend in the habitat. Much frogs, some snakes, birds, mammals, insects and crustaceans were also discovered. They are only slight diet differences between the main watercourses which probably are related to the characteristics of their fish fauna (e.g. much more sticklebacks when waters are becoming brackish; big amount of Atherina in salt marshes). No marked variations were found during a normal summer but fish is obviously less eaten during a severe drought. Comparing the frequency-distributions of fish in the diet and in the habitat, we found no selective predation in respect with fish (eel, cyprinids) size. From that point of view, the otter display a generalistic-opportunistic pattern of foraging. As far as the relative abundance of the various species is considered, otters take much less roaches and much more eels and tenches than present in the habitat. It remains to be seen if that is the consequence of a 'deliberate choice' or of a peculiar way of underwater huntig. A fact is that the otter principally eats bottom living fishes. [less ▲]

Detailed reference viewed: 30 (1 ULg)
Full Text
Peer Reviewed
See detailPeut-on utiliser l'auto-estimation à l'école ? Qu'en aurait dit DESCARTES ?
Leclercq, Dieudonné ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1991), 22

Detailed reference viewed: 27 (2 ULg)
Full Text
Peer Reviewed
See detailLe culte de la Persuasion. Peithô en Grèce ancienne
Pirenne-Delforge, Vinciane ULg

in Revue de l'Histoire des Religions (1991), 208

Detailed reference viewed: 42 (4 ULg)
Peer Reviewed
See detailIntérêt de la différence aterio-veineuse en O2 dans l'approche thérapeutique de l'hypertension intracrânienne post-traumatique
Franssen, Christine ULg; Hans, Pol ULg; Deprez, Josette ULg et al

in Agressologie : Revue Internationale de Physio-Biologie et de Pharmacologie Appliquées aux Effets de l'Agression (1991), 32(6-7), 366-368

Elevated intracranial pressure (ICP) is undoubtedly a determinant factor of outcome in severe head injured patient. Until now, medical treatment of elevated ICP in diffuse brain lesions consisted of ... [more ▼]

Elevated intracranial pressure (ICP) is undoubtedly a determinant factor of outcome in severe head injured patient. Until now, medical treatment of elevated ICP in diffuse brain lesions consisted of hyperventilation, CSF drainage, mannitol and barbiturates without accurate selection criteria. In fact, in comatose patients, the cerebral blood flow (CBF) can vary independently of the cerebral metabolic rate of oxygen (CMRO2) which is typically reduced. The venous oxygen saturation (SjO2) measured in the jugular bulb and the arterial-jugular oxygen difference (ajDO2) can be used for more appropriately selecting therapeutic measures. According to the following equation: CMRO2 = CBF x ajDO2, the measurement of the changes in ajDO2 might serve as an indicator of CBF adequacy, out of the presence of cerebral ischemia. A decreased ajDO2 suggests that CBF is excessive for cerebral metabolic requirements and an elevated ajDO2 indicates a decreased CBF. Consequently, treatment of elevated ICP in the presence of a low ajDO2 should be more oriented towards moderate hyperventilation and administration of metabolic depressive agents with maintenance of normal arterial blood pressure. Conversely, in case of high ajDO2, ICP control should aim to increase CBF by maintaining normocapnia, improving hemodynamic status or reducing extravascular volume accordingly. [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailCharacterization of an unusual thyroid response unit in the promoter of the human placental lactogen gene
Voz, Marianne ULg; Peers, Bernard ULg; Belayew, Alexandra et al

in Journal of Biological Chemistry (1991), 266(20), 13397-404

The human placental lactogen B (hCS-B) promoter activity is strongly stimulated by thyroid hormones in the rat pituitary GC cell line. The minimal DNA sequence required for stimulation, as determined by ... [more ▼]

The human placental lactogen B (hCS-B) promoter activity is strongly stimulated by thyroid hormones in the rat pituitary GC cell line. The minimal DNA sequence required for stimulation, as determined by transfection with 5' and 3' deletion mutants, spans 67 base pairs, from coordinate -97 to -31. DNase I footprinting experiments show that this thyroid response unit includes two adjacent binding sites: one for the thyroid receptor (-67/-41), the other for the pituitary-specific factor GHF1 (-95/-68). Neither region alone is sufficient to confer thyroid responsiveness. The thyroid receptor binding element (TBE) does not contain any repeats or palindromes but is composed of two different domains, one of which is very similar to the half-palindromic motif described by Glass et al. (Glass, C.K., Holloway, J.M., Devary, O.L., and Rosenfeld, M.G. (1988) Cell 54, 313-323). The other is very rich in purine. The normal human growth hormone (hGH-N) promoter, which is 94% similar to the hCS-B promoter, differs from its hCS-B counterpart precisely in this TBE. This difference may explain the opposite 3,5,3'-triiodothyronine (T3) regulation of these two genes. [less ▲]

Detailed reference viewed: 20 (0 ULg)
Peer Reviewed
See detailExperimental study of the non-linear behaviour of beam-to-column composite joints
Altmann, R.; Maquoi, René ULg; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (1991), 18

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailLes plantes emsiennes de Marchin (bord nord du Synclinorium de Dinant, Belgique). II. Forgesia curvata gen. et sp. nov.
Gerrienne, Philippe ULg

in Comptes Rendus de l'Académie des Sciences. Série II. Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (1991), 313

Detailed reference viewed: 5 (3 ULg)
Peer Reviewed
See detailL’ordinateur pour apprendre le latin
Denooz, Joseph ULg

in EVPRHOSYNE (1991), 19

Detailed reference viewed: 51 (4 ULg)
See detailUne note de l'Essai sur l'origine des langues de Jean-Jacques Rousseau. Analyse textuelle
Tilkin, Françoise ULg

in Espace pour un humanisme européen (1991), 8

Detailed reference viewed: 9 (4 ULg)
Peer Reviewed
See detailVirulence factors associated with cytotoxic necrotizing factor two in bovine diarrheic and septicemic strains of Escherichia coli.
Oswald, E.; De Rycke, J.; Lintermans, P. et al

in Journal of Clinical Microbiology (1991), 29

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailCharacterization of a set of variable number of tandem repeat markers conserved in Bovidae
Georges, Michel ULg; Gunawardana, A.; Threadgill, D. et al

in Genomics (1991), 11(1), 24-32

Screening purpose-built libraries with minisatellite probes, we have isolated 36 bovine variable number of tandem repeat markers (VNTRs) characterized by a mean heterozygosity of 59.3 within the American ... [more ▼]

Screening purpose-built libraries with minisatellite probes, we have isolated 36 bovine variable number of tandem repeat markers (VNTRs) characterized by a mean heterozygosity of 59.3 within the American Holstein breed. Matching probabilities and exclusion powers were estimated by Monte-Carlo simulation, showing that the top 5 to 10 markers could be used as a very efficient DNA-based system for individual identification and paternity diagnosis. The isolated VNTR systems should contribute significantly to the establishment of a bovine primary DNA marker map. Linkage analysis, use of somatic cell hybrids, and in situ hybridization demonstrate that these bovine VNTRs are scattered throughout the bovine genome, without evidence for proterminal confinement as in the human, and that at least some of them are organized as clusters. Moreover, Southern blot analysis and in situ hybridization demonstrate conservation of sequence and map location of minisatellites within Bovidae [less ▲]

Detailed reference viewed: 13 (4 ULg)
Full Text
Peer Reviewed
See detailLa biologie des infections par morbillivirus
Pastoret, Paul-Pierre ULg; Van Bressem, M. F.; Diallo, A. et al

in Annales de Médecine Vétérinaire (1991), 135

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detailPotentialités physiques et stratégies de mise en valeur dans le Haut Bassin du fleuve Gambie (Cas d'étude : le village de Téliré)
Henquin, Bruno; Avril, Claire; Bock, Laurent ULg et al

in Annales de Gembloux (1991), 4ème trimestre(4), 277-291

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailVariations de l'antigéniémie dans l'infection persistante des bovins par le virus de la diarrhée virale bovine (BVD)
Waxweiler, S.; Mignon, Bernard ULg; Boulanger, D. et al

in Annales de Médecine Vétérinaire (1991), 135

Detailed reference viewed: 5 (1 ULg)
Peer Reviewed
See detailOstéite sternale et médiastinite après chirurgie de pontage aorto-coronaire
DETROZ, B.; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Annales de Chirurgie (1991), 45(2), 128-35

Between 1980 and 1987, 31 cases of osteitis (n = 9) and/or mediastinitis (n = 22) were observed after 2,801 consecutive aorto-coronary bypasses (1.1%). Three types of treatment were used: 1) sternal ... [more ▼]

Between 1980 and 1987, 31 cases of osteitis (n = 9) and/or mediastinitis (n = 22) were observed after 2,801 consecutive aorto-coronary bypasses (1.1%). Three types of treatment were used: 1) sternal debridement with osteosynthesis and continuous mediastinal irrigation (n = 25); 2) sternal and mediastinal debridement with open drainage without osteosynthesis (n = 2); 3) incision and debridement of sternal abscesses (n = 4). The overall mortality was 26% (8/31), i.e. 11% (1/9) for isolated osteitis and 32% (7/22) for mediastinitis. Four factors were statistically associated with infection: reoperation for hemorrhage (19.4%, p less than 0.001); preoperative diabetes (25%, p less than 0.001), postoperative low cardiac output (55%, p less than 0.001), postoperative respiratory insufficiency (45%, p less than 0.001). [less ▲]

Detailed reference viewed: 52 (0 ULg)
Peer Reviewed
See detailBranchial Arch Anomalies in Trisomy 18
Verloes, Alain ULg; Seret, N.; Bernier, V. et al

in Annales de Génétique (1991), 34(1), 22-4

The authors report two newborns and one fetus with trisomy 18, who have severe anomalies of the first branchial arch: extreme microtia with imperforate external meatus in two cases, and hemifacial ... [more ▼]

The authors report two newborns and one fetus with trisomy 18, who have severe anomalies of the first branchial arch: extreme microtia with imperforate external meatus in two cases, and hemifacial microsomia in a third one. Those cases point to the huge phenotypic variability of the trisomy 18. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailAsymmetric Diels-Alder reactions of a nitroso compound derived from D-bornane-10,2-sultam
Gouverneur, Véronique; Dive, Georges ULg; Ghosez, Léon

in Tetrahedron, Asymmetry (1991), 2(12), 1173-1176

Detailed reference viewed: 13 (2 ULg)
Peer Reviewed
See detailIdentité sociale et fédéralisme
Jacquemain, Marc ULg; Doutrelepont, René; Vandekeere, Michel

in Fédéralisme - Régionalisme (1991), 2

Based on survey results, the paper shows that feelings of belonging go together witht different attitude toward federalism.

Detailed reference viewed: 11 (2 ULg)
Peer Reviewed
See detailComment utiliser les calcitonines dans l'ostéoporose ?
Reginster, Jean-Yves ULg

in Dialogue Omni-praticien (1991), 1233

Detailed reference viewed: 10 (2 ULg)
See detailLa phytotechnie du triticale.
Bodson, Bernard ULg

in Bulletin des Recherches Agronomiques de Gembloux (1991), 26(4), 507-518

Detailed reference viewed: 3 (0 ULg)
Peer Reviewed
See detailIntérêt de l'électromyostimulation de basse fréquence dans la rééducation du quadriceps
Constant, T.; Vanderthommen, Marc ULg

in STAPS : Revue Internationale des Sciences du Sport et de l'Education Physique (1991), 24

Detailed reference viewed: 6 (2 ULg)
Peer Reviewed
See detailEffects of specific dopaminergic agonists and antagonists in the open-field test.
Bruhwyler, J.; Chleide, E.; Liégeois, Jean-François ULg et al

in Pharmacology, Biochemistry & Behavior (1991), 39(2), 367-71

It has been found that dopaminergic transmission could be involved in some aspects of anxiety. The present study aims to explore this hypothesis further, using specific DA1 (SKF 38393) and DA2 ... [more ▼]

It has been found that dopaminergic transmission could be involved in some aspects of anxiety. The present study aims to explore this hypothesis further, using specific DA1 (SKF 38393) and DA2 (bromocriptine) agonists or DA1 (SCH 23390), and DA2 (zetidoline) antagonists in the open-field test. The results confirm previous studies indicating that DA1 and DA2 agonists predominantly increase locomotor activity, while DA1 and DA2 antagonists predominantly decrease it. However, at low doses, the four drugs increase the peripheral ambulation score significantly and, with the exception of zetidoline, also increase the central ambulation score. The observations made with zetidoline confirm the hypothesis that a specific presynaptic DA2 antagonism could be determinant for the disinhibitory effects of low doses of neuroleptics. A collateral action on 5HT transmission is also suggested to explain an hypothetic anxiolytic action of DA agonists and SCH 23390 at lower doses. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailKinetic study of the aspartate/glutamate carrier in intact rat heart mitochondria and comparison with a reconstituted system.
Sluse, Francis ULg; Evens, A.; Dierks, T. et al

in Biochimica et Biophysica Acta-Bioenergetics (1991), 1058

The homologous exchange of external [14C] aspartate/internal aspartate catalyzed by the aspartate/glutamate carrier of rat heart mitochondria was investigated using aspartate-loaded, glutamate-depleted ... [more ▼]

The homologous exchange of external [14C] aspartate/internal aspartate catalyzed by the aspartate/glutamate carrier of rat heart mitochondria was investigated using aspartate-loaded, glutamate-depleted mitochondria. An inhibitor-stop technique was developed for kinetic studies by applying pyridoxal phosphate. Direct initial rate determinations from the linear phase of [14C] aspartate uptake were insufficiently accurate at high external and/or low internal substrate concentrations. Therefore, the full time-course of [14C] aspartate uptake until reaching isotope equilibrium was fitted by a single exponential function and was used to calculate reliable initial steady-state rates. This method was applied in bisubstrate analyses of the antiport reaction for different external and internal aspartate concentrations. The kinetic patterns obtained in double reciprocal plots showed straight lines converging on the abscissa. This result is consistent with a sequential antiport mechanism. It implies the existence of a catalytic ternary complex that is formed by the translocator and substrate molecules bound from both sides of the membrane. The Km values for aspartate were clearly different for the external and the internal sides of the membrane, 216 +/- 23 microM and 2.4 +/- 0.5 mM, respectively. These values indicated a definite transmembrane asymmetry of the carrier. The same asymmetry became evident when investigating the isolated protein from bovine heart mitochondria after reconstitution into liposomes. In this case the Km values for external and internal aspartate were determined to be 123 +/- 11 microM and 2.8 +/- 0.6 mM, respectively. This comparison demonstrates a right-side out orientation of the carrier after insertion into liposomal membranes. The sequential transport mechanism of the aspartate/glutamate carrier, elucidated both in proteoliposomes and in mitochondria, also seems to be a common characteristic of other mitochondrial antiport carriers [less ▲]

Detailed reference viewed: 9 (2 ULg)
See detailLes restes anthracologiques du Titelberg.
Gerrienne, Philippe ULg; Fairon-Demaret, Muriel ULg

in Bulletin de la Société Préhistorique du Luxembourg (1991), 13

Detailed reference viewed: 4 (0 ULg)
Full Text
See detailHow do preschool teacher's requests influence children's behaviors ?
Crahay, Marcel ULg; Delhaxhe, Arlette

in Teaching & Teacher Education (1991), 7(3), 221-239

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailL'utilisation des forces tractrices en rivières naturelles
Petit, François ULg

in De Aardrijkskunde (1991), 15(2), 193-218

Detailed reference viewed: 11 (4 ULg)
Peer Reviewed
See detailPAF receptor and cache-oreilles effect. Simple PAF antagonists
Lamotte-Brasseur, Josette; Heymans, Françoise; Dive, Georges ULg et al

in Lipids (1991), 26(12), 1167-1171

Detailed reference viewed: 9 (2 ULg)
Peer Reviewed
See detailSténose de l'artère rénale droite par les piliers du diaphragme. A propos d'un cas
Vahdat, H.; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Journal des Maladies Vasculaires (1991), 16(3), 304-7

We present one case of arterial hypertension that had rapidly developed in a 23-year-old patient. Arteriography demonstrates a light stenosis of the root of the right renal artery and an obstruction of ... [more ▼]

We present one case of arterial hypertension that had rapidly developed in a 23-year-old patient. Arteriography demonstrates a light stenosis of the root of the right renal artery and an obstruction of the superior mesenteric artery. After an attempt of intraluminal dilatation had failed, we decided to carry out double revascularization with a venous graft. Postoperative control arteriography demonstrated early thrombosis in both grafts. Our second operation directly approached the lesion on the root of the renal artery, which was stenosed by muscle fibers from the right column of the diaphragm muscle. The resection of these fibers released the renal artery, which was otherwise normal, as was confirmed by the postoperative arteriogram. In a second part, we discuss the etiology of this double stenosis and our surgical strategy. [less ▲]

Detailed reference viewed: 9 (0 ULg)
See detailL'immersion dans la vie professionnelle dès la formation initiale : pourquoi ?
Beckers, Jacqueline ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1991), 2

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailConformational analysis of beta and gamma lactam antibiotics
Lamotte, Josette ULg; Dive, Georges ULg; Ghuysen, Jean-Marie ULg

in European Journal of Medicinal Chemistry (1991), 26(1), 43-50

Geometry optimization, superimposition searches and conformational analysis carried on several lactam antibiotics show that reactivity with the active-site serine penicillin-binding proteins is related to ... [more ▼]

Geometry optimization, superimposition searches and conformational analysis carried on several lactam antibiotics show that reactivity with the active-site serine penicillin-binding proteins is related to a particular spatial disposition of 2 flanking functional groups - namely a C = O or C-OH on 1 side and a carboxylate on the other - with respect to the central scissile amide bond. Such a binding entity is found in one of the most stable conformers of the tripeptide diacetyl-L-Lys-D-Ala-D-Ala conferring substrate activity, and in benzylpenicillin, cephapyrin, thienamycin, gamma-lactam, the 6-spiro-epoxypenicillin S and in one epimer of lactivicin, conferring inactivating potency. This binding entity generates a particular electronic distribution and the fact that it is conserved in compounds belonging to very different chemical families strongly suggests that it is an important feature required for enzyme recognition. [less ▲]

Detailed reference viewed: 85 (6 ULg)
Full Text
Peer Reviewed
See detailInfluence of basement membrane molecules on directional migration of human breast cell lines in vitro.
Coopman, P. J.; Bracke, M. E.; Lissitzky, J. C. et al

in Journal of Cell Science (1991), 98(Pt 3), 395-401

Spheroidal cell aggregates were prepared from four tumorigenic human breast cell lines (HBL-100 and three MCF-7 variants). Cells from these aggregates were allowed to migrate towards lanes of basement ... [more ▼]

Spheroidal cell aggregates were prepared from four tumorigenic human breast cell lines (HBL-100 and three MCF-7 variants). Cells from these aggregates were allowed to migrate towards lanes of basement membrane components coated on a glass substratum. Matrigel (reconstituted basement membrane) lanes permanently arrested the migration of one MCF-7 cell line, while migration of the others was permitted. Amongst several purified basement membrane constituents only laminin, not collagen type IV or fibronectin, was found to cause the same arrest of migration. Within the laminin molecule only the pepsin P1, not the elastase E8 fragment, efficiently arrested migration of that cell line. Although migration was inhibited by these components, time-lapse video recordings revealed that arrested cells still proliferated and actively ruffled on top of the coatings. These data suggest that, amongst several basement membrane components, laminin can function as a stop signal for cell migration. Within laminin, this activity seems to be mainly associated with the P1 fragment. We conclude that laminin is the major determinant of the barrier-function of the basement membrane, to which some cell types have become insensitive. [less ▲]

Detailed reference viewed: 13 (0 ULg)
Peer Reviewed
See detailThe seismic cataclysm of 29 March 1000 : genesis of a mistake
Alexandre, Pierre ULg

in Tectonophysics (1991), 193

Detailed reference viewed: 13 (2 ULg)
Peer Reviewed
See detailStructure du méthyl-4 pipérazinyl-1)-10 pyrido[4,3-b][1,4]benzothiazépine
Dupont, L.; Dideberg, O.; Liégeois, Jean-François ULg et al

in Acta Crystallographica Section C-Crystal Structure Communications (1991), C47

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailPathological Aspects of Carotid Plaques: Surgical and Clinical Significance
VAN DAMME, Hendrik ULg; Demoulin, J.C.; Limet, Raymond ULg

in VASA. Supplementum (1991), 32

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailTranscription des usages du sol par le modèle de potentiel
Binard, Marc ULg; Donnay, Jean-Paul ULg; Nadasdi, Istvan

in Mappemonde (1991), 3

The paper deals with an application of the potential model to the urban environment of the city of Luxembourg. Specific loadings are assigned to urban and vegetable land uses, identified according to a ... [more ▼]

The paper deals with an application of the potential model to the urban environment of the city of Luxembourg. Specific loadings are assigned to urban and vegetable land uses, identified according to a supervised classification of remote sensed SPOT data. Then, the two sets of loadings are separately submitted to potential models and the resulting images are merged by chromatic synthesis to obtain a map of the residential environment of the town. [less ▲]

Detailed reference viewed: 43 (5 ULg)
Peer Reviewed
See detailConserved KRAB protein domain identified upstream from the zinc finger region of Kox 8
Thiesen, H. J.; Bellefroid, E.; Revelant, O. et al

in Nucleic Acids Research (1991), 19(14), 3996

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailStructures du 11-formyl-5-(4-méthylpipérazin-1-yl)-11H-pyrido[2,3b][1,5]benzodiazépine et du 6-(4-méthylpipérazin-1-yl)-11-méthyl-11H-pyrido[2,3-b][1,4]benzodiazépine
Dupont, L.; Englebert, S.; Dideberg, O. et al

in Acta Crystallographica Section C-Crystal Structure Communications (1991), C47

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailHow to decrease pragmatic interferences : the impact of different techniques
Dardenne, Benoît ULg

in European Bulletin of Cognitive Psychology (1991), 11

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailLa cellule beta dans le diabète de type II: coupable ou victime?
SCHEEN, André ULg; Paquot, Nicolas ULg; Lefebvre, P. J.

in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (1991)

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailAntiamoebic and Antiplasmodial Activities of Alkaloids Isolated from Strychnos usambarensis
Wright, Colin; Bray, Dorothy; O'Neill, Melanie et al

in Planta Medica (1991), 57

Seven alkaloids isolated from Strychnos usambarensis have been assessed for in vitro activities against Entamoeba histolytica and Plasmodium falciparum and for in vivo activity against Plasmodium berghei ... [more ▼]

Seven alkaloids isolated from Strychnos usambarensis have been assessed for in vitro activities against Entamoeba histolytica and Plasmodium falciparum and for in vivo activity against Plasmodium berghei in mice. Strychnopentamine and 3'-4'-dihydrousambarensine were highly active against P. falciparum in vitro, but were inactve and non-toxic against P.berghei in vivo.Usambarensine, usambarine and 18,19-dihydrousambarine were highly active against E. histolytica in vitro, but were less active against P. falciparum in vitro. Nb-methylusambarensine was less active against both protozoa than was usambarensine, and akagerine possessed little antiprotozoal activity.Structure-activity relationships are discussed in the context of the reported cytotoxic and pharmacological properties of those alkaloids. [less ▲]

Detailed reference viewed: 30 (6 ULg)
Peer Reviewed
See detailDes nouveaux supports électroniques. Pour qui ? pour quoi ?
Denooz, Joseph ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1991), 27

Detailed reference viewed: 32 (3 ULg)
Full Text
Peer Reviewed
See detailPhotosystem II assembly in 2-day-old bean leaves during the first 16 hrs. of greening
Schoefs, Benoît; Franck, Fabrice ULg

in Comptes Rendus de l'Académie des Sciences. Série III, Sciences de la Vie (1991), 313(10), 441-445

We have studied the assembly of the photosynthetic apparatus during the greening of 2-day-old bean leaves in continuous white light by using fluorimetric methods. We have recorded 77 and 298 K ... [more ▼]

We have studied the assembly of the photosynthetic apparatus during the greening of 2-day-old bean leaves in continuous white light by using fluorimetric methods. We have recorded 77 and 298 K fluorescence kinetics at 690 nm in order to detect electron flow through the photosystem II reaction centre (RC(II)) at increasing greening periods. In those experiments, the 77 K fluorescence spectra were also considered. Charge separation is detected 1 hr. after the onset of the illumination. Room temperature fluorescence variation showing the << O-I-P >> phases are detected after 4 hrs. of illumination. Typical fluorescence bands at 688, 697 and 735 nm appear after 14 hrs. of illumination. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailGerminal centres and the immune response - Discussion
Cebra, J.; Schrader, C.; Shroff, K. et al

in Research in Immunology (1991), 142

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailOntogeny of radial and other astroglial cells in murine cerebral cortex
Misson, Jean-Paul ULg; Takahashi, Takao; Caviness, V. S.

in Glia (1991), 4

Detailed reference viewed: 3 (1 ULg)
Full Text
Peer Reviewed
See detailAbcès thyroïdien a streptocoque pneumoniae associé à un goitre nodulaire toxique. A propos d'un cas
Panas, N.; Zgheib, A.; Desaive, Claude ULg et al

in Annales de Chirurgie (1991), 45(5), 429-31

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic ... [more ▼]

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic inflammation induced by this association. [less ▲]

Detailed reference viewed: 51 (0 ULg)
Peer Reviewed
See detailOn the characterization of some terpenes from Renealmia alpinia Rott. (Maas) oleoresin.
Lognay, Georges ULg; Marlier, M.; Severin, M. et al

in Flavour and Fragrance Journal (1991), 6(1),

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailAugmentation of type IV collagenase, laminin receptor, and Ki67 proliferation antigen associated with human colon, gastric, and breast carcinoma progression.
D'Errico, A.; Garbisa, S.; Liotta, L. A. et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (1991), 4(2), 239-46

The proportion of neoplastic cells immunocytochemically positive for type IV collagenase (IVase), laminin receptor (LR), and Ki67 proliferation-associated antigen increased during the progression of human ... [more ▼]

The proportion of neoplastic cells immunocytochemically positive for type IV collagenase (IVase), laminin receptor (LR), and Ki67 proliferation-associated antigen increased during the progression of human colon, gastric, and breast carcinomas. Thirty cases of colonic adenoma were compared with 30 cases of Dukes' A or B stage carcinoma and ten cases of Dukes' C stage carcinoma. The percentage of positive cells increased significantly (P less than 0.001) for all three antigens comparing carcinomas with adenomas and Dukes' C stage compared with Dukes' A/B stage. The same pattern of antigen correlation with progression was found with 40 human gastric carcinomas. Gastric carcinomas classified as well-differentiated advanced stage contained a significantly higher proportion of tumor cells positive for IVase (P less than 0.001), LR (P less than 0.001), and Ki67 (P less than 0.001) compared with well-differentiated superficial tumors. Gastric carcinomas classified as poorly differentiated superficial had a significantly higher proportion of cells positive for Ki67 (P less than 0.016), but not IVase (P less than 0.069) or LR (P less than 0.075), compared with poorly differentiated advanced tumors. Metastasis of colon and gastric carcinoma retained the immunostaining pattern of the primary tumors. Thirty cases of breast neoplasia were compared with 30 adjacent samples of normal duct epithelium. A positive correlation (P less than 0.001) was found for the immunoreactivity of all three antigens in the invasive carcinomas compared with the normal epithelium. Invasive ductal carcinoma and invasive lobular carcinoma had a significantly higher percentage of immunoreactivity for the three antigens compared with corresponding in situ lesions. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailMyeloperoxidase and elastase as markers of leukocyte activation during cardiopulmonary bypass in humans
Faymonville, Marie ULg; Pincemail, Joël ULg; Duchateau, J. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (1991), 102

Detailed reference viewed: 41 (8 ULg)
Peer Reviewed
See detailRaynal à Liège: censure, vulgarisation, révolutions
Droixhe, Daniel ULg

in Studies on Voltaire (1991), 286

Detailed reference viewed: 30 (6 ULg)
Peer Reviewed
See detailACCUMULATION OF ACYL-ENZYME IN DD-PEPTIDASE-CATALYZED REACTIONS WITH ANALOGS OF PEPTIDE-SUBSTRATES
JAMIN, M.; Adam, Maggy; Damblon, Christian ULg et al

in Biochemical Journal (1991), 280(Part 2), 499-506

Thioester substrates can be used to study the hydrolysis and transfer reactions catalysed by beta-lactamases and DD-peptidases. With the latter enzymes, accumulation of the acyl-enzyme can be detected ... [more ▼]

Thioester substrates can be used to study the hydrolysis and transfer reactions catalysed by beta-lactamases and DD-peptidases. With the latter enzymes, accumulation of the acyl-enzyme can be detected directly. The efficiency of various amines as acceptor substrates was in excellent agreement with previous results obtained with peptide substrates of the DD-peptidases. The results indicated the presence of a specific binding site for the acceptor substrates, Although most of the results agreed well with a simple partition model, more elaborate hypotheses will be needed to account for all the data presented. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailA new Theory for frequencies computation of overhead lines with bundle conductors.
dubois, Hervé; Dal Maso, Filipo; Lilien, Jean-Louis ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1991), 1

Vertical, horizontal and torsional mechanical frequencies are studies for both single and bundle conductor lines. Models and tests are presented. These data are of particular impact on galloping ... [more ▼]

Vertical, horizontal and torsional mechanical frequencies are studies for both single and bundle conductor lines. Models and tests are presented. These data are of particular impact on galloping phenomenon. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailSécurité et violence dans les stades de football
Comeron, Manuel ULg

in Revue de Droit Pénal et de Criminologie (1991), 9

Analyse des facteurs de risque dans l'organisation d'un match de football professionnel et étude d'un noyau dur de supporters.

Detailed reference viewed: 27 (5 ULg)
Peer Reviewed
See detailtracheal agenesis: an unusual cause of neonatal respiratory distress
Battisti, Oreste ULg

in Pediatric Pulmonology (1991), 150

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailA propos de 2 cas de lymphangiomyomatose traités par agoniste de la LH-RH
RADERMECKER, Marc ULg; Corhay, Jean-Louis ULg; Broux, R. et al

in Revue Médicale de Liège (1991), 46(5), 286-93

Detailed reference viewed: 20 (0 ULg)
See detailEfficacité productive et rendements d'échelle dans les banques belges
Gathon, Henry-Jean ULg; Grosjean, Fabienne

in Cahiers Economiques de Bruxelles (1991), 130(Summer), 145-160

Detailed reference viewed: 4 (2 ULg)
Peer Reviewed
See detailImmunohistochemical expression of epidermal growth factor receptors in nuclei of a subpopulation of keratinocytes and sweat gland cells.
Pierard, Claudine ULg; Colige, Alain ULg; Arrese Estrada, Jorge ULg et al

in Dermatologica (1991), 183(1), 7-9

We have raised a polyclonal antibody to the 170-kD epidermal growth factor receptor. We found an intercellular pattern of immunoreactivity in the epidermis as well as a positivity of the cytoplasm of ... [more ▼]

We have raised a polyclonal antibody to the 170-kD epidermal growth factor receptor. We found an intercellular pattern of immunoreactivity in the epidermis as well as a positivity of the cytoplasm of keratinocytes and eccrine secretory cells. In some samples, a nuclear labelling was evidenced in these type of cells. There is a close resemblance in the topographical distribution of these cells with nuclear labelling and those synthesizing DNA under phytohaemagglutinin stimulation. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detailCephalic and extracephalic pressure pain thresholds in chronic tension-type headache.
Schoenen, Jean ULg; Bottin, D.; Hardy, F. et al

in Pain (1991), 47(2), 145-9

Pressure pain thresholds were assessed with an algometer (Somedic Inc.), over the forehead, temple and suboccipital region as well as over the Achilles tendon. A group of 32 patients suffering from ... [more ▼]

Pressure pain thresholds were assessed with an algometer (Somedic Inc.), over the forehead, temple and suboccipital region as well as over the Achilles tendon. A group of 32 patients suffering from chronic tension-type headache was compared to 20 healthy controls and to 10 migraineurs without aura. Although individual values were widely scattered, pressure pain thresholds were on average significantly lower in chronic tension-type headache, not only at pericranial sites but also over the Achilles tendon. Only 50% of these patients had one or more pericranial thresholds 1.5 S.D. below the mean of controls. After muscular biofeedback therapy, all pain thresholds were on average increased. Along with results obtained previously, the present data support the hypothesis that diffuse disruption of central pain-modulating systems, possibly due to a modified limbic input to the brain-stem, is pivotal in the pathophysiology of chronic tension-type headache. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Peer Reviewed
See detailLaminin binding and internalization by human and murine mammary gland cell lines in vitro.
Coopman, P. J.; Nuydens, R.; Leunissen, J. et al

in European Journal of Cell Biology (1991), 56(2), 251-9

We have studied the binding and internalization of Engelbreth-Holm-Swarm mouse sarcoma laminin labeled with colloidal gold (LN-G40) by human and murine mammary gland cell lines. Interactions between the ... [more ▼]

We have studied the binding and internalization of Engelbreth-Holm-Swarm mouse sarcoma laminin labeled with colloidal gold (LN-G40) by human and murine mammary gland cell lines. Interactions between the LN-G40 probe and the cells spread on a glass coverslip were monitored with video-enhanced contrast microscopy (Nanovid). Transmission electron microscopy allowed the quantitation of the LN-G40 probe at various cellular locations. During the first 15 min, a homogeneous binding of LN-G40 probe to the cell surface was observed with all cell lines. This binding did not occur with gold particles that were not conjugated to laminin. Then, the LN-G40 probe began to cluster on the cell surface and was, during the following 20 h, internalized by pits that were not coated. In the cells, the LN-G40 probe sometimes showed saltatory movements along linear tracks. The LN-G40 probe was intracellularly found in vesicles, multivesicular bodies, cisternal structures, and lysosomes, suggesting the degradation of the internalized laminin. However, not all cell surface-bound LN-G40 probe was internalized after 20 h. Differences between the cell lines were quantitative, but no clear correlation could be made between migration of cells on laminin and internalization of laminin. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailPredictive value and rate of change of blood pressure throughout adolescence : a Belgian prospective study
Saint-Remy, Annie ULg; Rorive, Georges ULg

in Journal of Hypertension (1991), 9(suppl 6), 266-267

We performed a prospective study on the natural course of blood pressure throughout adolescence. The major goals were to assess the predictive value of a high blood pressure level at the age of 12 years ... [more ▼]

We performed a prospective study on the natural course of blood pressure throughout adolescence. The major goals were to assess the predictive value of a high blood pressure level at the age of 12 years and the feasibilty of developing a screening test for the early detection of young subjects at risk of developing chronic hypertension. By measuring the relationship between the initial level and subsequent changes in blood pressure, we looked for a phenomenon previously demonstrated in adults. [less ▲]

Detailed reference viewed: 14 (4 ULg)
Peer Reviewed
See detailIncreased expression of the laminin receptor in human colon cancer.
Cioce, V.; Castronovo, Vincenzo ULg; Shmookler, B. M. et al

in Journal of the National Cancer Institute (1991), 83(1), 29-36

It has been proposed that among the various cell-surface proteins capable of interacting with laminin, the 67-kd high-affinity laminin receptor plays a crucial role during tumor invasion and metastasis ... [more ▼]

It has been proposed that among the various cell-surface proteins capable of interacting with laminin, the 67-kd high-affinity laminin receptor plays a crucial role during tumor invasion and metastasis. In this study, the expression of laminin-receptor-precursor messenger RNA (mRNA) and 67-kd protein was analyzed in human colon adenocarcinoma. In 22 of 23 patients with colon cancer, we found a 2- to 23-fold increase in levels of laminin-receptor-precursor mRNA in the cancer tissues compared with those in matched normal adjacent colonic mucosa. In 10 of 11 cases studied, the level of 67-kd laminin receptor, detected by affinity-purified anti-laminin-receptor synthetic peptide antibodies on immunoblots of matched tumor and normal tissue extracts, was higher in the colon carcinoma tissue. Immunodetection of laminin receptor in tissue sections using anti-laminin-receptor-peptide antibodies confirmed that the increased expression of laminin receptor was specifically associated with the cancer cells. In a series of 72 paraffin sections of colon lesions, we observed a correlation between the expression of the laminin receptor and the Dukes' classification. Our observations indicate that increased expression of laminin-receptor-precursor mRNA is associated with enhanced levels of the 67-kd laminin receptor as well as with the invasive phenotype of colon carcinoma. Detection of this metastasis-associated gene product may be a valuable adjunct in the evaluation of human colon cancer. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailPerspectives diagnostiques et thérapeutiques de l'érythropoïétine
Beguin, Yves ULg; Sautois, Brieuc ULg; Fillet, Georges ULg

in Médecine et Hygiène (1991), 49

L'érythropoïétine est une hormone produite par le rein en réponse à une hypoxie rénale et qui stimule l'activité érythropoïétine de la moelle osseuse. Le dosage de l'érythropoïétine sérique, toujours ... [more ▼]

L'érythropoïétine est une hormone produite par le rein en réponse à une hypoxie rénale et qui stimule l'activité érythropoïétine de la moelle osseuse. Le dosage de l'érythropoïétine sérique, toujours interpété en fonction de l'hématocrite circulante, est utilise dans le diagnostic différentiel des polyglobulies et dans certains cas particuliers d'anémie. L'utilisation thérapeutique de l'érythropoïétine recombinée a permis de corriger l'anémie de l'insuffisance rénale chronique et est actuellement étudiée dans d'autres indications. [less ▲]

Detailed reference viewed: 52 (1 ULg)
Full Text
Peer Reviewed
See detailMétoda Marginilor Rigidizate
Rigo, Philippe ULg; Mircea Soare, V.

in Studii şi Cercetări de Mecanică Aplicată (1991)

Detailed reference viewed: 25 (0 ULg)
Peer Reviewed
See detailMolecular inhibition of cancer cell invasion and metastasis.
Castronovo, Vincenzo ULg; Stetler-Stevenson, W. G.; Sobel, M. E. et al

in Princess Takamatsu Symposia (1991), 22

A group of coordinated cellular processes, not just one gene product, is responsible for invasion and metastasis, the most life-threatening aspect of cancer. It is now recognized that negative factors may ... [more ▼]

A group of coordinated cellular processes, not just one gene product, is responsible for invasion and metastasis, the most life-threatening aspect of cancer. It is now recognized that negative factors may be just as important as positive elements. Genetic changes causing an imbalance of growth regulation lead to uncontrolled proliferation necessary for both primary tumor and metastasis expansion. However, unrestrained growth does not, by itself, cause invasion and metastasis. This phenotype may require additional genetic changes. Thus, tumorigenicity and metastatic potential have both overlapping and separate features. Invasion and metastasis can be facilitated by proteins which stimulate tumor cell attachment to host cellular or extracellular matrix determinants, tumor cell proteolysis of host barriers, such as the basement membrane, tumor cell locomotion, and tumor cell colony formation in the target organ for metastasis. Facilitory proteins may act at many levels both intracellularly and extracellularly, but are counterbalanced by factors which can block their production, regulation or action. A common theme has emerged: in addition to loss of growth control, an imbalanced regulation of adhesion, proteolysis, and motility appears to be required for invasion and metastasis. Re-equilibrating the expression of the genes involved in these tumor invasion related events could potentially constitute the basis for new anti-cancer therapeutic strategies. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailBlood pressure, the prevalence of cardiovascular diseases, and exposure to cadmium : a population study
Staessen, J.; Amery, A.; Bernard, A. et al

in American Journal of Epidemiology (1991), 134(3), 257-267

In a population study conducted from 1985 to 1989 in Belgium, the authors investigated whether exposure to cadmium is associated with blood pressure elevation and with an increased prevalence of ... [more ▼]

In a population study conducted from 1985 to 1989 in Belgium, the authors investigated whether exposure to cadmium is associated with blood pressure elevation and with an increased prevalence of cardiovascular diseases. The participants, aged 20-88 years, constituted a random sample of the households living in two low exposure areas (n = 803) and two high exposure areas (n = 1,283). For each exposure level, a rural and an urban district were selected. The cadmium levels in blood (8.5 vs. 11.0 nmol/liter) and urine (7.2 vs. 8.7 nmol/24 hours) were significantly (p less than 0.001) raised in the two high exposure areas compared with the two low exposure areas (p less than 0.001). Systolic pressure was similar in both rural areas, but in the urban area with high exposure systolic pressure was 5 mmHg (p less than 0.001) higher than in the control town. Diastolic pressure was similar in the four districts and the same was true for the prevalence of hypertension and of other cardiovascular diseases. Adjustment of systolic pressure for blood and urinary cadmium did not remove the difference in systolic pressure between both urban areas, suggesting that it was not related to the cadmium burden on the environment. Further analyses in individual subjects showed that neither blood pressure nor the presence of cardiovascular diseases were significantly and positively correlated with blood and urinary cadmium. Thus, the present population study did not confirm the hypothesis that increased exposure of the population to cadmium is associated with blood pressure elevation and with a higher prevalence of cardiovascular diseases. [less ▲]

Detailed reference viewed: 11 (2 ULg)
Peer Reviewed
See detailComparaison de modèles agrométéorologiques de type statistique empririque construits à partir de différents ensembles de variables météorologiques
Palm, Rodolphe ULg; De Bast, A.; Lahlou, M.

in Bulletin des Recherches Agronomiques de Gembloux (1991), 26(1), 71-89

On compare des modèles agrométéorologiques de type statistique empirique construits à partir de différents ensembles de variables météorologiques et destinés à prévoir les rendements en maïs dans une ... [more ▼]

On compare des modèles agrométéorologiques de type statistique empirique construits à partir de différents ensembles de variables météorologiques et destinés à prévoir les rendements en maïs dans une série de départements français. La qualité des ajustements est très satisfaisante, pour autant qu'on dispose d'un nombre suffisant de variables explicatives potentielles, mais la valeur prédictive des modèles construits est nulle, puisque leur utilisation introduit une variable supplémentaire. On montre également que l'étude des résidus prédits par la méthode du "jackknife" ne permet pas d'apprécier valablement la qualité du modèle. [less ▲]

Detailed reference viewed: 24 (6 ULg)
Full Text
See detailParticularités physiologiques et physiopathologiques de la fonction pulmonaire des bovins
Lekeux, Pierre ULg

in Point Vétérinaire (1991), 23(140), 793-799

This review détails the specific factors of respiratory function in cattle, the purpose being to understand cattle's great sensitivity te respiratory conditions, to be able to breed them for an optimal ... [more ▼]

This review détails the specific factors of respiratory function in cattle, the purpose being to understand cattle's great sensitivity te respiratory conditions, to be able to breed them for an optimal functioning of their respiratory metabolism, and to adapt the prevention of respiratory conditions to the physiological specificity of this species. For each main respiratory syndrome, the consequences on the vital functions, and particularly for the respiratory function, are analyzed (9 tables, 33 references). [less ▲]

Detailed reference viewed: 82 (7 ULg)
Peer Reviewed
See detailThe Solar Abundance of Iron: a "Final" Word !
Biémont, Emile ULg; Baudoux, M.; Kurucz, R.L. et al

in Astronomy and Astrophysics (1991), 249

Detailed reference viewed: 4 (1 ULg)
Peer Reviewed
See detailMétabolisme et toxicité pulmonaires des pesticides chez les mammifères
Delaunois, A.; Gustin, Pascal ULg; Ansay, M.

in Annales de Médecine Vétérinaire (1991), 135

Detailed reference viewed: 37 (1 ULg)
Full Text
Peer Reviewed
See detailFunctional domains of the 67-kDa laminin receptor precursor.
Castronovo, Vincenzo ULg; Taraboletti, G.; Sobel, M. E.

in Journal of Biological Chemistry (1991), 266(30), 20440-6

We report the characterization of two functional domains of the metastasis-associated 67-kDa laminin receptor (67-LR). Using synthetic peptides deduced from the cDNA sequence of the 37-kDa precursor of ... [more ▼]

We report the characterization of two functional domains of the metastasis-associated 67-kDa laminin receptor (67-LR). Using synthetic peptides deduced from the cDNA sequence of the 37-kDa precursor of the laminin receptor (37-LRP) as well as their corresponding affinity-purified polyclonal antibodies, we identified a unique laminin binding site as well as a membrane-associated domain of the receptor. In laminin dot blot and solid phase radioligand assays, a 20 amino acid synthetic peptide (IPCNNKGAHSVGLMWWMLAR, amino acid residues 161-180, designated peptide G) specifically bound to laminin with high affinity (Kd = 5 x 10(-8) M). Peptide G also specifically eluted the 67-LR from a laminin affinity column. Peptide G and laminin reacted with a 1:1 stoichiometry, suggesting that there is one recognition site on laminin for the peptide G domain. Immunofluorescence studies, performed on permeabilized and nonpermeabilized human A2058 melanoma cells using 10 different affinity-purified antibodies to distinct regions of the 37-LRP, identified an unusually short membrane-associated domain that was consistent with a computer predicted transmembrane domain (residues 86-101). Our data demonstrate for the first time that the 37-LRP has two functional domains consistent with the characteristics of the mature 67-LR. Furthermore, we propose peptide G as a potential inhibitor of tumor cell interactions with laminin. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailQuestion sociale et politique pontificale. L'itinéraire d'un démocrate chrétien: Antoine Pottier (1849-1923)
Jadoulle, Jean-Louis ULg

in Revue belge de philologie et d'histoire (1991), t. LXIX(n°2), 300-321

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailContribution a l'etude de l'influence de divers facteurs meteorologiques sur la production et la qualite des fibres chez le cotonnier Gossypium hirsutum L.
Mergeai, Guy ULg; Demol, J.

in Bulletin des Recherches Agronomiques de Gembloux (1991), 26(1),

Detailed reference viewed: 1 (0 ULg)
Peer Reviewed
See detailLe financement des communautés et des régions dans la perspective du Fiscal Federalism
Jurion, Bernard ULg

in Revue du Centre d'Etude du Fédéralisme (1991)

Detailed reference viewed: 5 (1 ULg)
Peer Reviewed
See detailSéance anatomo-clinique: hémoptysies et insuffisance rénale aigue chez un patient de 60 ans
MENDES, P; PARTOUNE, B; DECHENNE, Charles ULg et al

in Acta Clinica Belgica (1991), 46(4), 237-242

Detailed reference viewed: 37 (0 ULg)
Full Text
Peer Reviewed
See detailDetermination of Thiamin and Its Phosphate Esters in Cultured Neurons and Astrocytes Using an Ion-Pair Reversed-Phase High-Performance Liquid Chromatographic Method
Bettendorff, Lucien ULg; Peeters, Maryline; Jouan, Caroline ULg et al

in Analytical Biochemistry (1991), 198(1), 52-59

A sensitive method, based on fluorescence detection, for the determination of thiamin derivatives after precolumn derivatization is described. The separation is achieved on a PRP-1 column using ion-pair ... [more ▼]

A sensitive method, based on fluorescence detection, for the determination of thiamin derivatives after precolumn derivatization is described. The separation is achieved on a PRP-1 column using ion-pair reversed-phase HPLC. This method is especially well adapted to the detection of thiamin triphosphate in complex mixtures such as tissue extracts. The detection limit for TTP is 50 fmol. The contents of thiamin derivatives were determined in primary cultures of rat cerebellar granule neurons and cerebral astrocytes. The amount of TTP is about five times higher in neurons than in astrocytes. Thus in rat brain TTP seems to be essentially associated with neurons and the intracellular concentration is estimated to be about 0.2 microM. Our results suggest the existence, in nerve cells, of specific regulatory mechanisms not related to the blood-brain barrier and responsible for the maintenance of thiamin homeostasis in brain. [less ▲]

Detailed reference viewed: 28 (9 ULg)
Full Text
Peer Reviewed
See detailEffect of catechins and citrus flavonoids on invasion in vitro.
Bracke, M.; Vyncke, B.; Opdenakker, G. et al

in Clinical & Experimental Metastasis (1991), 9(1), 13-25

Catechins, a group of flavonoid molecules, inhibit invasion of mouse MO4 cells into embryonic chick heart fragments in vitro. The anti-invasive effects can be ranked as follows: (+)-catechin greater than ... [more ▼]

Catechins, a group of flavonoid molecules, inhibit invasion of mouse MO4 cells into embryonic chick heart fragments in vitro. The anti-invasive effects can be ranked as follows: (+)-catechin greater than (-)-epicatechin greater than 3-O-methyl-(+)-catechin greater than 3-O-palmitoyl-(+)-catechin. Most of the catechins are unstable in cell culture media, and their spontaneous rearrangement products tend to bind to extracellular matrix (ECM). Due to these interactions proteases such as tissue-type plasminogen activator (t-PA) are linked to the ECM glycoprotein laminin. This leads to a partial inactivation of the enzyme. Within the group of catechins we found a positive correlation between anti-invasive activity and linking of t-PA to laminin. Citrus flavonoids are also anti-invasive in vitro (tangeretin greater than nobiletin greater than hesperidin = naringin). However, these stable molecules show poor affinity for ECM, and do not link enzymes to laminin. These data suggest that catechins and citrus flavonoids inhibit invasion in vitro by different mechanisms. [less ▲]

Detailed reference viewed: 10 (2 ULg)
Peer Reviewed
See detailBelgian GIS Survey
Donnay, Jean-Paul ULg

in International GIS Sourcebook (1991), 1991-1992

Detailed reference viewed: 3 (2 ULg)
See detailLe Musée de la Famenne: un défi, une réussite
Van Ruymbeke, Muriel ULg

in La Vie wallonne (1991), (414-415), 157-160

Detailed reference viewed: 33 (9 ULg)
Full Text
Peer Reviewed
See detailFrom ethnobotanical uses of Strychnos henningsii to antiinflammatories, analgesics and antispasmodics
Tits, Monique ULg; Damas, Jacques ULg; Quetin-Leclercq, Joëlle et al

in Journal of Ethnopharmacology (1991), 34

Strychnos henningsii GILG is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints, malaria and snake bites. Different preliminary ... [more ▼]

Strychnos henningsii GILG is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints, malaria and snake bites. Different preliminary pharmacological experiments are described. The results show that some of the reported folk medicinal applications of S. henningsii can be at least partially explained by the presence of retuline-like alkaloids, whose use could lead to new antinociceptive (antiinflammatory and analgesic) and antispasmodic drugs. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
See detailChoix de l'habitat par le lynx européen et par sa proie principale, le chevreuil, dans un milieu de moyenne montagne (massif vosgien). 1. le cas du chevreuil
Anciaux, Marie Rose; Herrenschmidt, Véronique; Libois, Roland ULg

in Cahiers d'Ethologie (1991), 11(1), 51-66

Since 1983, 12 lynxes were reintroduced in the forests of Eastern France (massif des Vosges). They use their habitat in a patchy way. In this part, the authors deal with the ecological distridution of ... [more ▼]

Since 1983, 12 lynxes were reintroduced in the forests of Eastern France (massif des Vosges). They use their habitat in a patchy way. In this part, the authors deal with the ecological distridution of their main prey, the roe deer. It is to see to what extent the prey distribution can influence the predator habits. Roe deer observations were made during 4 consecutive springs and 3 consecutive summers and related with the environmental characteristics of the forest plots: physiographical factors, vegetation type, vegetation structure, relative cover of vegetation layer... Eight discriminant analysis were performed. They suggest that in our study area, the roe deer spatial distribution is mainly influenced by the altitude and the non deciduous tree cover. Other factors of less importance are the global tree cover and the understory (scrub layer). Moreover it seems that the presence of the red deer can also influence the roe deer habitat utilization. [less ▲]

Detailed reference viewed: 30 (4 ULg)
Full Text
Peer Reviewed
See detailQuantitative mineralogical analysis of Cobalt and Copper distribution in historical slags from Küre (Turkey)
Pirard, Eric ULg

in Canadian Mining and Metallurgical Bulletin (The) (1991), 84(946), 87-91

Detailed reference viewed: 18 (8 ULg)
Full Text
Peer Reviewed
See detailMesure de la dénitrification biologique potentielle dans les sols à l'aide de l'acétylène.
Trodoux, E.; Tychon, Bernard ULg; Vander Borght, Paul ULg

in Revue de l’Agriculture = Landbouwtijdschrift (1991), 44(4), 637-648

De nombreuses méthodes ont été établies pour quantifier et définir la cinétique de dénitrification mais elles se sont toutes confrontées à la difficulté de doser l'azote de l'air (N2) qui est l'élément ... [more ▼]

De nombreuses méthodes ont été établies pour quantifier et définir la cinétique de dénitrification mais elles se sont toutes confrontées à la difficulté de doser l'azote de l'air (N2) qui est l'élément terminal de la chaîne de Payne (1973) : NO3 → NO2 → NO → N2O → N2. L'utilisation de l'acétylène a résolu ce problème en permettant l'inhibition de la réduction de l'oxyde nitreux (N2O) en N2, l'oxyde nitreux étant facilement dosable par chromatographie gazeuse. La technique utilisée lors de ce travail consiste à prélever un échantillon de sol dans l'horizon de surface. Après homogénéisation, il est placé dans des fioles à pénicilline hermétiques de 120 ml. Une préincubation de 50 h à 20-22° C sous anaérobiose engendre l'élimination des nitrates endogènes présents au départ dans le sol, ce qui permet par la suite d'ajouter des quantités précises de nitrates en vue d'effectuer des bilans de transformation du NO3 en N2O. Cette préincubation est suivie d'une incubation sous air, en présence d'acétylène (10 % vol/vol), à 20° C et à 100 % de saturation en eau. Sous ces conditions, la production de N-N2O et la disparition de N-NO3 sont mesurées, permettant ainsi de quantifier les bilans de transformation. En reportant les résultats obtenus pour 1 ha de sol (pour les 20 premiers cm), 12 kg d'azote sur les 20 présents au départ ont dénitrifié sur une période de 5 jours. De plus, cette disparition suit une cinétique à allure précise. Si ces estimations s'avéraient correspondre à la réalité, les mécanismes en cause seraient alors de la plus grande importance, tant pour l'agriculture en améliorant l'utilisation de l'azote, que pour l'environnement et la pollution de l'air et de l'eau. [less ▲]

Detailed reference viewed: 31 (1 ULg)
Peer Reviewed
See detailA partial wetting model of aerobic tricklin filters
Crine, Michel ULg; Schlitz, Marc; Vandevenne, L.

in Chemical Engineering (1991), 46

Detailed reference viewed: 4 (2 ULg)
See detailStarters pour la charcuterie
Evrard, P.; Rikir, R.; Thonart, Philippe ULg

in Viande et Bien-être = Vlees en Welzijn (1991), (2), 3-7

Detailed reference viewed: 5 (1 ULg)
Peer Reviewed
See detailUse of Peep in Management of Life-Threatening Status Asthmaticus: A Method for the Recovery of Appropriate Ventilation-Perfusion Ratio
Broux, R.; Foidart, G.; Mendes, P. et al

in Applied Cardiopulmonary Pathophysiology [=ACP] (1991), 4(1), 79-83

In 15 patients with asthma attack, evidence of the uneven distribution of air flow during controlled ventilation was obtained by detection of ventilatory asynchronism expressed by the incurvated profile ... [more ▼]

In 15 patients with asthma attack, evidence of the uneven distribution of air flow during controlled ventilation was obtained by detection of ventilatory asynchronism expressed by the incurvated profile of tracheal pressure waves associated with the repetitive interruptions of air flow. It was observed that low values of PEEP (mean: 5 +/- 2.5 cm H 2O) induced an increase in transbronchial pressure able to overcome ventilatory asynchronism. In these conditions, an appropriate ventilation-perfusion ratio was restored and improved gas exchanges as indicated by the mean increase of arterial PO 2 from 66.3 mmHg (+/- 2.57) to 96.89 mmHg (+/- 4.41) (p = 0.0005) associated with a mean decrease in arterial PCO 2 from 53.66 mmHg (+/- 2.71) to 42.07 mmHg (+/- 1.64) (p = 0.0005). Simultaneously hemoglobin oxygen saturation rose from 82.31% (+/- 1.97%) to 95.74% (+/- 0.5%). In our patients, such values of PEEP were not high enough to influence the pulmonary arterial circulation. The means of the pulmonary arterial pressures obtained before (syst.: 32.3; diast.: 15.1; mean: 22.00 mmHg) were quite the same (p greater than 0.2) as with PEEP (syst.: 32.00; diast.: 14.00; mean: 21.1 mmHg). The mean of the wedge pressure was found to be 8.3 (+/- 74 mmHg) prior to and 8.4 (+/- 0.68 mmHg) after PEEP (p greater than 0.3). Mean cardiac output rose slightly from 5.27 l/min (+/- 0.24) to 5.77 l/min (+/- 0.38) during PEEP (p = 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

Detailed reference viewed: 9 (0 ULg)
See detailCOST 93
Bera, François ULg

in VITA Magazine (1991), (88),

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailImportance de l'axe hypophyso-hepatique dans le regulation hormonale de la croissance chez le bovin.
Renaville, Robert ULg; Portetelle, Daniel ULg; Sneyers, M. et al

in Bulletin des Recherches Agronomiques de Gembloux (1991), 26(2),

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailEcologie de la loutre (Lutra lutra) dans le Marais Poitevin 2. Aperçu général du régime alimentaire
Libois, Roland ULg; Rosoux, René

in Mammalia (1991), 55(1), 35-47

From 1982 to 1987, 165 otter spraints samples were collected in the Marais Poitevin area (Western France). Eel is the main prey whichever way the results are presented: relative occurrence, relative ... [more ▼]

From 1982 to 1987, 165 otter spraints samples were collected in the Marais Poitevin area (Western France). Eel is the main prey whichever way the results are presented: relative occurrence, relative abundance or relative biomass. Despite their high frequency or abundance in the spraints, other preys such as Atherina, mosquito-fish, stickelback, stone loach, bluegill or invertebrates, are quite negligible as far as biomass is considered. In turn, less frequent bigger preys (mammals, tenches) are of geater importance. Except for cyprinid fishes, more frequent in spring, no marked seasonal variations were found in the otters diet. [less ▲]

Detailed reference viewed: 43 (1 ULg)
Full Text
Peer Reviewed
See detailEvidence that the interaction between circulating IgA and fibronectin is a normal process enhanced in primary IgA nephropathy.
Davin, J. C.; Li Vecchi, M.; Nagy, J. et al

in Journal of Clinical Immunology (1991), 11(2), 78-94

A solid-phase ELISA was set up to measure the direct binding capacity (BC) of different, commercially available, purified human IgA preparations to plates coated with human fibronectin (FN). It was found ... [more ▼]

A solid-phase ELISA was set up to measure the direct binding capacity (BC) of different, commercially available, purified human IgA preparations to plates coated with human fibronectin (FN). It was found that secretory, polymeric, and, to a much lesser extent, monomeric IgA exhibited elevated FN-BC as compared to their BC to plates coated with bovine serum albumin. This binding was specific since not observed with human IgG or IgM antibodies. In addition, we noted that this interaction was dose dependent, Ca2+ dependent, saturable, and not covalent, was inhibited by soluble FN, but not by a prior incubation of FN-coated plates with anti-human fibronectin antibodies, and appeared to involve on the dimeric FN other structures than its heparin-binding, collagen-binding, or C1q-binding domains. Similar experiments conducted with normal plasma indicated that plasma IgA, but not plasma IgG or IgM, was also capable of significant binding to FN-coated plates. In contrast, serum IgA did not significantly bind to those plates under otherwise identical experimental conditions. Thus, the coagulation process induces a strong decrease in the FN-BC of circulating IgA, which implies the necessity of using plasma rather than serum to study such interactions. The apparent molecular weight of plasma IgA interacting with FN-coated plates ranged between 450 and 900 kd, and its major binding characteristics were quite similar to those observed with purified polymeric IgA. The FN-BC of plasma IgA was then measured by the same ELISA in 30 patients with primary IgA nephropathy (IgAN) and in 23 healthy controls. The mean FN-BC of plasma IgA was significantly higher in patients than in normal controls. This enhancement was due mainly to the augmentation in the concentration of circulating "macromolecular" IgA and was significantly correlated with the plasma levels of IgA-FN complexes. However, the pathogenetic role of these findings was probably not determinant since similar observations were made in alcoholic liver cirrhosis without urinary abnormalities and since the FN-BC of plasma IgA or the plasma levels of IgA-FN complexes were not correlated with the various biological parameters of evolutivity of primary IgAN. In conclusion, these studies suggest that the ability of polymeric IgA to directly bind to FN is involved in the formation of circulating IgA-FN complexes and that this normal binding process, although enhanced in IgAN, is probably not responsible for kidney injury, at least in the patients studied. [less ▲]

Detailed reference viewed: 13 (2 ULg)