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See detailThe antiangiogenic factor 16K PRL induces programmed cell death in endothelial cells by caspase activation
Martini, J. F.; Piot, C.; Humeau, L. M. et al

in Molecular Endocrinology (2000), 14(10), 1536-49

We asked whether the antiangiogenic action of 16K human PRL (hPRL), in addition to blocking mitogen-induced vascular endothelial cell proliferation, involved activation of programmed cell death. Treatment ... [more ▼]

We asked whether the antiangiogenic action of 16K human PRL (hPRL), in addition to blocking mitogen-induced vascular endothelial cell proliferation, involved activation of programmed cell death. Treatment with recombinant 16K hPRL increased DNA fragmentation in cultured bovine brain capillary endothelial (BBE) and human umbilical vein endothelial (HUVE) cells in a time- and dose-dependent fashion, independent of the serum concentration. The activation of apoptosis by 16K hPRL was specific for endothelial cells, and the activity of the peptide could be inhibited by heat denaturation, trypsin digestion, and immunoneutralization, but not by treatment with the endotoxin blocker, polymyxin-B. 16K hPRL-induced apoptosis was correlated with the rapid activation of caspases 1 and 3 and was blocked by pharmacological inhibition of caspase activity. Caspase activation was followed by inactivation of two caspase substrates, poly(ADP-ribose) polymerase (PARP) and the inhibitor of caspase-activated deoxyribonuclease (DNase) (ICAD). Furthermore, 16K hPRL increased the conversion of Bcl-X to its proapoptotic form, suggesting that the Bcl-2 protein family may also be involved in 16K hPRL-induced apoptosis. These findings support the hypothesis that the antiangiogenic action of 16K hPRL includes the activation of programmed cell death of vascular endothelial cells. [less ▲]

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See detailClinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantation.
Baron, Frédéric ULg; Gothot, André ULg; Salmon, Jean ULg et al

in British Journal of Haematology (2000), 111(3), 745-53

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome ... [more ▼]

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome, termed autologous GVHD has notable anti-tumour activity in animal studies. We intended to induce autologous GVHD with CyA in patients undergoing an autologous HSCT. We prospectively studied 118 patients with miscellaneous malignancies undergoing an autologous HSCT with low-dose CyA to characterize the clinical syndrome, its frequency and clinical course, and to determine the factors affecting its incidence. Patients received CyA from d -1 through to d 28, first starting at 2 mg/kg intravenously and then orally as soon as feasible. The dose was adjusted to achieve pre-dose blood levels around 100 ng/ml. A skin biopsy was performed when a skin rash was observed. Thirty-three percent of the patients developed clinical GVHD: clinical stage 1 in 21 patients, stage 2 in seven patients, and stage 3 in three patients. Although total body irradiation (TBI) or high-dose cyclophosphamide were previously thought to be needed, autologous GVHD occurred in five out of 12 patients (42%) after a preparative regimen with high-dose melphalan alone. Autologous GVHD was significantly more frequent in patients older than 33 years, in patients who had received high doses of granulocyte-macrophage colony forming units (CFU-GM) and in those with a diagnosis of myeloid malignancy, compared with those with lymphoid malignancies or solid tumours. A significant negative association was also found with HLA-DR6. In lymphoma patients, GVHD occurred more frequently in advanced disease than in first or second complete remission (CR1-2) patients. All other factors studied were not predictive for GVHD. In conclusion, CyA-induced GVHD is reproducibly and safely induced with doses of CyA adapted to achieve blood levels around 100 ng/ml. In retrospective analysis, there was no survival advantage for patients with GVHD. Phase III trials with this approach are needed to evaluate its anti-tumoral effect. [less ▲]

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See detailCellulite: from standing fat herniation to hypodermal stretch marks.
Pierard, Gérald ULg; NIZET, Jean-Luc ULg; PIERARD-FRANCHIMONT, Claudine ULg

in American Journal of Dermatopathology (2000), 22(1), 34-7

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens ... [more ▼]

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens. A control group consisted of 4 women and 11 men showing no evidence of cellulite. The lumpy aspect of the dermohypodermal interface appeared to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite identified by the mattress phenomenon was related to the presence of focally enlarged fibrosclerotic strands partitioning the subcutis. Such strands possibly serve as a physiologic buttress against fat herniation limiting the outpouching of fat lobules on pinching the skin. These structures might represent a reactive process to sustained hypodermal pressure caused by fat accumulation. Full-blown cellulite likely represents subjugation of the hypertrophic response when connective tissue is overcome by progressive fat accumulation. Histologic aspects reminiscent of stretch marks are identified within the hypodermal strands, resulting in clinical skin dimpling. [less ▲]

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See detailp63 is a prostate basal cell marker and is required for prostate development.
Signoretti, Sabina; Waltregny, David ULg; Dilks, James et al

in American Journal of Pathology (2000), 157(6), 1769-75

The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many ... [more ▼]

The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many epithelial organs and its germline inactivation in the mouse results in agenesis of organs such as skin appendages and the breast. Here, we show that prostate basal cells, but not secretory or neuroendocrine cells, express p63. In addition, prostate basal cells in culture predominantly express the DeltaNp63alpha isotype. In contrast, p63 protein is not detected in human prostate adenocarcinomas. Finally, and most importantly, p63(-/-) mice do not develop the prostate. These results indicate that p63 is required for prostate development and support the hypothesis that basal cells represent and/or include prostate stem cells. Furthermore, our results show that p63 immunohistochemistry may be a valuable tool in the differential diagnosis of benign versus malignant prostatic lesions. [less ▲]

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See detailCrystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family.
Bompard-Gilles, C.; Remaut, H.; Villeret, V. et al

in Structure (2000), 8(9), 971-80

BACKGROUND: beta-Lactam compounds are the most widely used antibiotics. They inactivate bacterial DD-transpeptidases, also called penicillin-binding proteins (PBPs), involved in cell-wall biosynthesis ... [more ▼]

BACKGROUND: beta-Lactam compounds are the most widely used antibiotics. They inactivate bacterial DD-transpeptidases, also called penicillin-binding proteins (PBPs), involved in cell-wall biosynthesis. The most common bacterial resistance mechanism against beta-lactam compounds is the synthesis of beta-lactamases that hydrolyse beta-lactam rings. These enzymes are believed to have evolved from cell-wall DD-peptidases. Understanding the biochemical and mechanistic features of the beta-lactam targets is crucial because of the increasing number of resistant bacteria. DAP is a D-aminopeptidase produced by Ochrobactrum anthropi. It is inhibited by various beta-lactam compounds and shares approximately 25% sequence identity with the R61 DD-carboxypeptidase and the class C beta-lactamases. RESULTS: The crystal structure of DAP has been determined to 1.9 A resolution using the multiple isomorphous replacement (MIR) method. The enzyme folds into three domains, A, B and C. Domain A, which contains conserved catalytic residues, has the classical fold of serine beta-lactamases, whereas domains B and C are both antiparallel eight-stranded beta barrels. A loop of domain C protrudes into the substrate-binding site of the enzyme. CONCLUSIONS: Comparison of the biochemical properties and the structure of DAP with PBPs and serine beta-lactamases shows that although the catalytic site of the enzyme is very similar to that of beta-lactamases, its substrate and inhibitor specificity rests on residues of domain C. DAP is a new member of the family of penicillin-recognizing proteins (PRPs) and, at the present time, its enzymatic specificity is clearly unique. [less ▲]

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See detailErgotamine in the acute treatment of migraine: a review and European consensus.
Tfelt-Hansen, P.; Saxena, P. R.; Dahlof, C. et al

in Brain : A Journal of Neurology (2000), 123 ( Pt 1)

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe ... [more ▼]

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe reviewed the pre-clinical and clinical data on ergotamine as it relates to the treatment of migraine. From this review, specific suggestions for the patient groups and appropriate use of ergotamine have been agreed. In essence, ergotamine, from a medical perspective, is the drug of choice in a limited number of migraine sufferers who have infrequent or long duration headaches and are likely to comply with dosing restrictions. For most migraine sufferers requiring a specific anti-migraine treatment, a triptan is generally a better option from both an efficacy and side-effect perspective. [less ▲]

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See detailIncreased synovial fluid levels of soluble CD23 are associated with an erosive status in rheumatoid arthritis (RA).
Ribbens, Clio ULg; Bonnet, V.; Kaiser, Marie-Joëlle ULg et al

in Clinical & Experimental Immunology (2000), 120(1), 194-199

Synovial fluid (SF) levels of soluble CD23 (sCD23) were determined in 96 patients presenting with an inflammatory knee effusion (73 with RA and 23 with reactive arthritis (ReA) serving as a control ... [more ▼]

Synovial fluid (SF) levels of soluble CD23 (sCD23) were determined in 96 patients presenting with an inflammatory knee effusion (73 with RA and 23 with reactive arthritis (ReA) serving as a control inflammatory non-erosive group) and were correlated with the degree of joint destruction, with local immune parameters (IL-1beta, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12 and sCD25) and with serum markers of inflammation, C-reactive protein and erythrocyte sedimentation rate. RA patients, classified as erosive or not according to Larsen's grade, were separated as follows: (i) 13 patients with non-erosive RA; (ii) 16 RA patients with erosions in hands but not in knees, matched for disease duration with the first group; (iii) 44 RA patients with hand and knee erosions, matched with the second group for rheumatoid factor positivity but of longer disease duration. SF sCD23 levels were significantly increased in both erosive RA groups compared with non-erosive diseases, whether RA or ReA (P < 0.05), whose SF levels were not different. SF IL-10 showed a similar profile to that of SF sCD23 and was the only other parameter characteristic of erosive RA, but no direct correlation was found between the two. SF sCD23 was significantly correlated with IL-12 (r = 0.65, P = 0.0001) and sCD25 (r = 0.39, P = 0.0019) exclusively in the two erosive RA populations. In conclusion, these data showing that increased levels of sCD23 are not only found in the SF of erosive joints but also in knee SF of patients with erosive RA but without knee x-ray-diagnosed erosions suggest that this parameter might be of predictive value for joint destruction. Longitudinal studies are however needed to confirm its potential clinical interest. [less ▲]

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See detailSystemic Induction Of Phytoalexins In Cucumber In Response To Treatments With Fluorescent Pseudomonads
Ongena, MARC ULg; Daayf, F.; Jacques, Philippe ULg et al

in Plant Pathology (2000), 49(4),

The Pseudomonas putida isolate BTP1 and its sid2 mutant M3 were recently reported to protect cucumber against Pythium aphanidermatum root rot. This protection was mainly associated with an accumulation of ... [more ▼]

The Pseudomonas putida isolate BTP1 and its sid2 mutant M3 were recently reported to protect cucumber against Pythium aphanidermatum root rot. This protection was mainly associated with an accumulation of antifungal phenolics in the treated roots. In this study, analyses of root extracts from split-root experiments showed that these phytoalexins were produced systemically. Indeed, several antifungal molecules accumulated similarly in both treated and nontreated root parts of plants protected against P. aphanidermatum with BTP1 or M3. In addition, analyses of leaf samples also revealed increased amounts of fungitoxic molecules in PGPR-treated plants, although the nature of these molecules appeared to be different from those detected in roots. The antifungal compounds isolated both from roots and leaves were mainly detected in acid-hydrolyzed extracts containing aglycones. These results suggest that PGPR can elicit phytoalexins systemically in cucumber and that the overall defence response is not based on a single phytoalexin but is chemically complex and organ-specific. [less ▲]

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See detailLocalization of Nadph-Protochlorophyllide Reductase in Plastids of Barley at Different Greening Stages
Barthelemy, X.; Bouvier, G.; Radunz, A. et al

in Photosynthesis Research (2000), 64(1), 63-76

The localization of protochorophyllide (Pchlide) and of NADPH-protochlorophyllide oxidoreductase (POR, EC 1.6.99.1) within (etio)chloroplasts has been investigated at selected stages of greening of barley ... [more ▼]

The localization of protochorophyllide (Pchlide) and of NADPH-protochlorophyllide oxidoreductase (POR, EC 1.6.99.1) within (etio)chloroplasts has been investigated at selected stages of greening of barley seedlings. Pchlide pigment and POR protein contents were evaluated in different plastid membrane fractions by fluorescence spectroscopy and immunoblot analysis using a monospecific polyclonal antibody raised against the purified enzyme. Fluorescence analysis showed the presence of Pchlide in both the envelope and thylakoid membranes. During greening, the Pchlide content, expressed on a total protein basis, decreased in thylakoid membranes, whereas it increased in the envelope membranes. POR proteins were detected mainly in thylakoid membranes at early greening stages. In contrast, the weak amount of POR proteins was associated more specifically with envelope membranes of mature chloroplasts. Whatever the greening stage, thylakoid-bound Pchlide and POR proteins were more abundant in the thylakoid regions which remained unsolubilized after mild Triton treatment used as standard procedure to prepare PS II particles. This suggests the preferential association of Pchlide and POR to the appressed regions of thylakoids. [less ▲]

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See detailEvaluating risk in unstable angina: role of pharmacological stress echocardiography.
Pierard, Luc ULg

in European heart journal (2000), 21(13), 1041-3

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See detailDual Formulations for the Modeling of Thin Electromagnetic Shells using Edge Elements
Geuzaine, Christophe ULg; Dular, Patrick ULg; Legros, Willy ULg

in IEEE Transactions on Magnetics (2000), 36(4), 799-803

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See detailRéflexions sur l'avenir de la Belgique et de Bruxelles
Martiniello, Marco ULg; Swyngedouw, Marc

in Utinam : Revue de Sociologie et d'Anthropologie (2000), 3

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See detailEffects of cold and warm ischemia on the mitochondrial oxidative phosphorylation of swine lung.
Willet, Katty; Detry, Olivier ULg; Lambermont, Bernard ULg et al

in Transplantation (2000), 69(4), 582-588

BACKGROUND: The aim of the study was to investigate the consequence of warm and cold ischemia on lung mitochondria in order to define bioenergetic limits within lung could be suitable for pulmonary ... [more ▼]

BACKGROUND: The aim of the study was to investigate the consequence of warm and cold ischemia on lung mitochondria in order to define bioenergetic limits within lung could be suitable for pulmonary transplantation. METHODS: Twenty-two pigs underwent lung harvesting after lung flush with Euro-Collins solution. Mitochondria were isolated from fresh lungs, from lungs submitted to 24 or 48 hr of cold ischemia, to 30 or 45 min of warm ischemia, and to 30 min of warm ischemia followed by 24 or 48 hr of cold ischemia. Mitochondrial oxidative phosphorylation parameters were determined in isolated mitochondria by in vitro measurement of oxygen consumption. RESULTS: Relative to controls, mitochondria submitted to cold ischemia showed an alteration in the oxidoreductase activities of the respiratory chain but no membrane permeability alteration. After 48 hr of cold ischemia, there was a decrease in the yield of the oxidative phosphorylation. Thirty minutes of warm ischemia did not alter the mitochondrial respiratory parameters. However, lung submitted to 45 min of warm ischemia showed mitochondrial damage as a decrease in the oxidative phosphorylation efficiency and ADP availability but no change in the oxidoreductase activities. Relative to cold ischemia alone, 30 min of warm ischemia preceding cold ischemia promoted no significant change in the respiratory parameters. CONCLUSIONS: On bioenergetic basis, lung submitted to warm ischemia could be suitable for transplantation if the warm ischemia duration does not exceed 30 min. This could be a major concern in lung procurement from non-heart beating donors. [less ▲]

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See detailPour concevoir et déployer des dispositifs d'accompagnement d'équipes éducatives dans l'élaboration de pratiques collectives
Mouvet, Bernadette ULg; Lenoir, Anne-Sophie; Massart, Valérie ULg et al

in Point sur la Recherche en Education (Le) (2000), 17

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See detailAlteration of thyroid hormones, insulin-like growth factor-I (IGF-I) and IGFBPs in finishing calves treated with dexamethasone
Bertozzi, Carlo; Massart, Serge; Darras, Veerle et al

in Canadian Journal of Animal Science (2000), 80

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See detailThe Bureaucracy of Crime : J. G. Ballard’s Cocaine Nights and the Speculative Thriller
Delville, Michel ULg

in Analele Universităţii Oradea - Seria Filologie, Fascicola Limba şi literatura (2000), 8

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See detailOral contraception and cardiovascular risk factors during adolescence
Paulus, Dominique; Saint-Remy, Annie ULg; JeanJean, Michel

in Contraception (2000)

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study ... [more ▼]

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study was conducted in 24 Belgian secondary schools. Most students (1526 adolecents aged 12-17 years) agreed to participate (participation rate: 83.6%). Smoking, physical activity habits, menarche, and OC use were assessed by a self-administered questionnaire. Total cholesterol level, blood pressure and anthropometric measurements were also measured. Fourteen per cent of mature girls (14%, n=92) were OC users. Two-thirds of them (66.3%, n=61) were taking OC which contained either gestodene or desogestrel. Blood pressure and BMI were similar for OC users and non-users. Total cholesterol level was significantly higher in OC users than in non-users (191 mg/dL versus 172 mg/dL). Logistic regression model confirmed the significant influence of OC use on total cholesterol level (OR=3.08). OC users were also often smokers (39% versus 20% for non-users). In conclusion, the present study has found significant relationship between OC use and cardiovascular risk factors i.e., high total cholesterol and smoking. The first implication is a need for further research on lipoprotein profile in young OC users. Secondly, the combined use of OC and smoking in teenagers calls for preventive actions. [less ▲]

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See detailVery Low Surfactant Protein C Contents in Newborn Belgian White and Blue Calves with Respiratory Distress Syndrome
Danlois, F.; Zaltash, S.; Johansson, J. et al

in Biochemical Journal (2000), 351(Pt 3), 779-87

We have studied a respiratory distress syndrome (RDS) occurring in newborn calves of the Belgian White and Blue (BWB) breed that represents the large majority of beef cattle in Belgium. Pulmonary ... [more ▼]

We have studied a respiratory distress syndrome (RDS) occurring in newborn calves of the Belgian White and Blue (BWB) breed that represents the large majority of beef cattle in Belgium. Pulmonary surfactant isolated from 14 BWB newborn calves that died from RDS and from 7 healthy controls was analysed for composition and surface activity. An extremely low content or, in some instances, an absence of surfactant protein C (SP-C) was detected in the RDS samples by Western blotting and differential amino acid analysis [0.03+/-0.01% (w/w) relative to total phospholipids, compared with 0.39+/-0.06% for healthy controls (means+/-S.E.M., P < 0.001)]. The contents of surfactant protein B (SP-B) were similar in RDS and control samples. The crude surfactant samples isolated from RDS calves had higher ratios of total protein to total phospholipid, altered phospholipid profiles and lower SP-A contents. Both crude and organic extracts of RDS surfactant samples showed increased dynamic surface tension compared with healthy controls when evaluated with a pulsating-bubble surfactometer. The addition of purified SP-C to organic extracts of RDS surfactant samples lowered surface tension. Strongly decreased levels of mature SP-C associated with fatal RDS and altered surface activity in vitro have, to the best of our knowledge, not been previously reported. The mechanisms underlying RDS and the decrease in SP-C in BWB calves remain to be established. [less ▲]

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See detailMelanoma screening: results of the first one-day campaign in Belgium (‘Melanoma Monday’)
Vandaele, M.; Richert, Bertrand ULg; Van der Endt, J. M. et al

in Journal of the European Academy of Dermatology & Venereology (2000), 14

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a ... [more ▼]

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a media campaign, with more relevant information and the opportunity for free skin inspections. Methods: A ‘Task Force’ organized a media campaign in April 1999 and convinced 65% of the Belgian dermatologists to give up 4 h of their time to do free skin examinations for skin cancer on Monday 26 April 1999; it was called ‘Melanoma Monday’. Results: A total 2767 patients were screened. We found 25 melanomas and suspected 59 basal cell carcinomas. In the following 4 weeks another 141 melanomas were found. These 166 melanomas found in one month represent 15 –20% of the total number of melanomas per year in Belgium. Summary: A media campaign with relevant information combined with screening opportunities can lead to the early detection of melanomas in a large number of patients and can continue to alert people at risk in the following weeks. [less ▲]

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See detailTechnical efficiency of European railways: a distance function approach
Coelli, Tim; Perelman, Sergio ULg

in Applied Economics (2000), 32

This study has two principal objectives. The first objective is to measure and compare the performance of European railways. The second objective is to illustrate the usefulness of econometric distance ... [more ▼]

This study has two principal objectives. The first objective is to measure and compare the performance of European railways. The second objective is to illustrate the usefulness of econometric distance functions in the analysis of production in multioutput industries, where behavioural assumptions such as cost minimization or profit maximization, are unlikely to be applicable. Using annual data on 17 railways companies during 1988± 1993, multioutput distance functions are estimated using corrected ordinary least squares (COLS). The resulting technical efficiency estimates range from 0.980 for the Netherlands to 0.784 for Italy, with a mean of 0.863. The distance function results are also compared with those obtained from single-output production functions, where aggregate output measures are formed using either total revenue or a Tornqvist index. The results obtained indicate substantial differences in parameter estimates and technical efficiency rankings, casting significant doubt upon the reliability of these single-output models, particularly when a total revenue measure is used to proxy aggregate output. [less ▲]

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See detailDelayed control of axial compressors
Aernouts, Werner; Sepulchre, Rodolphe ULg; Roose, Dirk

in International Journal of Bifurcation & Chaos in Applied Sciences & Engineering (2000), 10(5),

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See detailLa néosporose chez la chèvre : résultats de deux enquêtes sérologiques dans l'Ouest de la France
Chartier, C.; Baudry, C.; Losson, Bertrand ULg et al

in Point Vétérinaire (2000), 31

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See detailLa variation de l’équilibre glycémique (mais pas du poids) est corrélée positivement à la modification du risque cardiovasculaire absolu chez le patient diabétique
Hadjadj, Samy; Guilloteau, Gérard; Weekers, Laurent ULg et al

in Archives des Maladies du Coeur et des Vaisseaux (2000), 93(8), 1033-1036

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See detailRelationship between the drift of macroinvertebrates and the activity of brown trout in a small stream
Giroux, F.; Ovidio, Michaël ULg; Philippart, Jean-Claude ULg et al

in Journal of Fish Biology (2000), 56(5), 1248-1257

Brown trout Saline trutta were most active in a small stream at night. dusk and dawn when drift rate was highest, but correlations between hourly drift rates and the trout's activity varied substantially ... [more ▼]

Brown trout Saline trutta were most active in a small stream at night. dusk and dawn when drift rate was highest, but correlations between hourly drift rates and the trout's activity varied substantially between individuals, between different dates for a single individual, and between different periods of the daily cycle. On some occasions. the trout were responsive to the total drift rate, either at night or during the day, and on others to the largest drifting organisms only (terrestrial organisms, adults of Ephemeroptera, Diptera and Trichoptera). The study supports the idea that trout adapt their activity pattern to the abundance of drifting prey, either as generalists towards any organism, or as specialists towards the largest ones. (C) 2000 The Fisheries Society of the British Isles. [less ▲]

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See detailL'éclairage : à nouveaux critères, nouveaux outils de mesure, de calcul et de simulation
Eugène, Christian; Rombauts, Patrick; Embrechts, Jean-Jacques ULg et al

in Revue de l'Electricité et de l'Electronique (2000), 7

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See detailDNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase.
Verdemato, P. E.; Brannigan, J. A.; Damblon, Christian ULg et al

in Nucleic Acids Research (2000), 28(19), 3710-8

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and ... [more ▼]

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and thermodynamic studies were carried out to obtain a model of the DNA-binding process. Nuclear magnetic resonance (NMR) studies map the DNA-binding site to helix 5, and a loop region (residues 151-160) which form the recognition helix and the 'wing' of a helix-turn-wing motif, respectively. The NMR data also suggest the absence of a large conformational change in the protein upon binding to DNA. Hence, an O:(6)-methylguanine (O:(6)meG) lesion would be inaccessible to active site nucleophile Cys146 if the modified base remained stacked within the DNA duplex. The experimentally determined DNA-binding face of Ada-C was used in combination with homology modelling, based on the catabolite activator protein, and the accepted base-flipping mechanism, to construct a model of how Ada-C binds to DNA in a productive manner. To complement the structural studies, thermodynamic data were obtained which demonstrate that binding to unmethylated DNA was entropically driven, whilst the demethylation reaction provoked an exothermic heat change. Methylation of Cys146 leads to a loss of structural integrity of the DNA-binding subdomain. [less ▲]

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See detailActualité choisie du TIG et de la formation
Dantinne, Michaël ULg; Van Doosselaere, Denis

in Revue de Droit Pénal et de Criminologie (2000), (11),

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See detailEntre stalle et prie-Dieu. La religieuse liégeoise en prière
Henneau, Marie-Elisabeth ULg

in Revue de l'Histoire des Religions (2000), 217(3), 327-344

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See detailA natural dominant negative P2X1 receptor due to deletion of a single amino acid residue.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Van Geet, Chris et al

in Journal of Biological Chemistry (2000)

We describe a naturally occurring dominant negative P2X1 mutant. This mutant lacks one leucine within a stretch of four leucine residues in its second transmembrane domain (TM2) (amino acids 351-354 ... [more ▼]

We describe a naturally occurring dominant negative P2X1 mutant. This mutant lacks one leucine within a stretch of four leucine residues in its second transmembrane domain (TM2) (amino acids 351-354). Confocal microscopy revealed proper plasma membrane localization of the mutant in stably transfected HEK293 cells. Nevertheless, voltage-clamped HEK293 cells expressing mutated P2X1 channels failed to develop an ATP or ADP-induced current. Furthermore, when co-expressed with the wild type receptor in Xenopus oocytes, the mutated protein exhibited a dose-dependent dominant negative effect on the normal ATP or ADP-induced P2X1 channel activity. These data indicate that deletion of a single apolar amino acid residue at the inner border of the P2X1 TM2 generates a nonfunctional channel. [less ▲]

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See detailL'etude clinique du mois. Insulino-independance prolongee apres transplantation d'ilots de langerhans chez le patient diabetique de type 1: l'aboutissement d'un reve?
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(8), 803-5

A Canadian research team recently reported a series of 7 consecutive patients with type 1 brittle diabetes who could achieve sustained excellent metabolic control in the absence of insulin therapy after ... [more ▼]

A Canadian research team recently reported a series of 7 consecutive patients with type 1 brittle diabetes who could achieve sustained excellent metabolic control in the absence of insulin therapy after successful islet transplantation. This exceptional success, which contrasts with previous less favourable results, is probably due to the transplantation of a higher number of islets of good quality and to the use of a new glucocorticoid-free immunosuppressive regimen. These remarkable results which provide proof of the principle that islet transplantation can be reproducibly successful, at least for one year, may raise new hope in patients with type 1 diabetes. However, the problem of supply and demand of islets is huge and will require a careful, and probably difficult, selection of the best candidates to benefit from this new therapeutic approach. [less ▲]

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See detailGelling properties of whey proteins after enzymic fat hydrolysis
Blecker, Christophe ULg; Paquot, Michel ULg; Deroanne, C.

in Journal of Food Science (2000), 65(4), 561-563

The effect of residual fat hydrolysis upon the gelation of whey protein concentrate (WPC) was studied. Gelling properties of a commercial WPC and lipase-treated WPC were evaluated on the basis of least ... [more ▼]

The effect of residual fat hydrolysis upon the gelation of whey protein concentrate (WPC) was studied. Gelling properties of a commercial WPC and lipase-treated WPC were evaluated on the basis of least concentration endpoint gelation, penetration test, texture profile analysis and water-holding capacity. Heat treatment of lipase-treated WPC led to gels with the highest hardness, springiness, cohesiveness and water retention. Such transformed WPC could be advantageously used to help improve texture in formulated meat, bakery, and confectionery products. [less ▲]

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See detailLes stratégies de reproduction chez les poissons labridés méditerranéens
Ylieff, Marc ULg

in Cahiers d'Ethologie (2000), 20(1), 113-138

In contrast to tropical environments, Mediterranean fish assemblages have been exposed to greater seasonal fluctuations of climatic factors (water temperature, photoperiod), which have impacted more or ... [more ▼]

In contrast to tropical environments, Mediterranean fish assemblages have been exposed to greater seasonal fluctuations of climatic factors (water temperature, photoperiod), which have impacted more or less significantly on the biology of fish. The labrid fishes (wrasses) are good examples of how climatic changes influence behavioural strategies. The European wrasses differ mainly from the tropical ones by their particular reproductive behavioural patterns. In these wrasses, the variety of the reproductive strategies (hermaphroditism or gonochorism, spawning seasonality in open water or on substrates, degrees of parental care, etc.) make it possible to study the evolution of these strategies. If in tropics, most of wrasses exhibit planktonic spawning, the Mediterranean ones adapted their behaviour, developing modes of reproduction unusual in tropics: short periods of reproduction, spawning eggs on substrates or in elaborated nest, parental cares. This evolution is dictated, in particular, by the pressure of climatic factors, such as water temperature on the presence or the absence of parental care. Of the 21 Mediterranean species, almost all the species studied lay their eggs on substrates or in a nest built by the large territorial male. Only Coris julis, Thalassoma pavo and Xyrichthys novacula (protogynous hermaphroditism fishes) spawn in open water (planktonic spawning) as tropical species do. Moreover, the majority of Symphodus males have complex social structures where nesting territorial, satellite and sneaker males can be recognised. These sneakers adopt reproductive behavioural patterns known as alternative reproductive behaviour. They can either steal the spawn (streaking), or steal the female (sneaking). Finally, the majority of these Symphodus give parental care throughout each nesting cycle (2 to 5 nests are elaborated during the reproductive season in spring), which always comprises three phases: nest building phase (construction with alive algae of a substrate for spawning or a true nest in form of cup), sexual activity phase (the very moment the females come to spawn in the nest) and fanning phase (oxygenation of eggs, by the beat of the pectoral fins, until hatching). The diversity of the biological and behavioural adaptations developed by the numerous tropical and temperate species of labrid fishes allow us to consider the family as an ideal group to investigate various problems in behavioural ecology. [less ▲]

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See detailAcute pancreatitis attributed to the use of interferon alfa-2b
Eland, I. A.; Rasch, M. C.; Sturkenboom, M. J. et al

in Gastroenterology (2000), 119(1), 230-233

Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection. The first patient was a 40-year-old man ... [more ▼]

Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection. The first patient was a 40-year-old man who developed acute pancreatitis after 15 weeks of treatment with 3 MU IFN-alpha subcutaneously (SC) 3 times weekly and 1200 mg ribavirin. After disappearance of symptoms and normalization of laboratory values, oral intake of solid foods and IFN-alpha therapy were restarted. Within hours, a relapse of acute pancreatitis occurred. A rechallenge with IFN-alpha 4 days later was followed by a prompt increase in serum lipase level, and IFN-alpha therapy was discontinued. The second patient was a 38-year-old man who developed acute pancreatitis 2 hours after SC administration of 5 MU IFN-alpha. Ultrasound endoscopy showed sludge in the gallbladder. The patient was rechallenged 5 weeks later with 3 MU IFN-alpha SC. Although serum amylase and lipase levels increased after readministration of IFN-alpha, treatment was continued. The patient was readmitted 2 weeks later with severe abdominal pain, and IFN-alpha administration was discontinued. Considering the temporal relationship between the start of IFN-alpha treatment and development of acute pancreatitis, the absence of other clear etiologic factors for acute pancreatitis, disappearance of symptoms after discontinuation of IFN-alpha, and positive reactions to rechallenge, IFN-alpha is the most probable cause for development of acute pancreatitis in these patients. [less ▲]

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See detailOsmotic behaviour of in vitro produced bovine blastocysts in cryoprotectant solutions as a potential predictive test of survival
Kaidi, Safia; Donnay, I.; Lambert, Philippe ULg et al

in Cryobiology (2000), 41

The osmotic behavior of bovine blastocysts produced in vitro was filmed during exposure to and dilution of cryoprotectant solutions used for vitrification. The relationship between the changes in the ... [more ▼]

The osmotic behavior of bovine blastocysts produced in vitro was filmed during exposure to and dilution of cryoprotectant solutions used for vitrification. The relationship between the changes in the diameter of embryos and their subsequent survival was assessed. Embryos collected on Day 6 and Day 7 postinsemination were exposed to 10% glycerol (GLY) for 5 min, 10% GLY + 20% ethylene glycol (EG) for 5 min, and 25% Gly + 25% EG for 30 s, before dilution in 0.85 M galactose and finally in embryo transfer freezing medium (ETF). Embryos that had a higher probability of survival behaved as perfect osmometers, shrinking, reexpanding, or swelling according to an identical pattern, whereas embryos that deviated from this standard usually did not survive. The initial embryo diameter, duration of shrinkage and expansion in 10% glycerol, duration of reexpansion in ETF, and final embryo diameter were clearly predictive of the ability to hatch after culture in vitro. On a given day postinsemination, larger blastocysts were more likely than smaller blastocysts to survive and hatch after exposure to cryoprotectants with or without vitrification. [less ▲]

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See detailEcological, morphological and allozymic differentiation between diploid and tetraploid knapweeds (Centaurea jacea) from a contact zone in the Belgian Ardennes
Hardy, O. J.; Vanderhoeven, SONIA ULg; De Loose, M. et al

in New Phytologist (2000), 146(2), 281-290

In the northeastern part of Belgium, the Centaurea jacea complex shows extensive morphological variation and is represented by a diploid (2n = 22) and a tetraploid (2n = 44) cytotype. Polysomic ... [more ▼]

In the northeastern part of Belgium, the Centaurea jacea complex shows extensive morphological variation and is represented by a diploid (2n = 22) and a tetraploid (2n = 44) cytotype. Polysomic inheritance of allozyme markers in the tetraploids, suggesting autopolyploidy, is here demonstrated for the first time. In order to test whether the tno cytotypes occupy distinct habitats and possess different gene pools, patterns of allozymic and morphological variation were investigated in relation to ploidy level and site characteristics in 26 populations from the Belgian Ardennes. The two cytotypes showed a parapatric distribution, the diploids occurring at higher elevations (mostly above 500 m) than the tetraploids (mostly below 500 m). Three mixed populations were found near the contact zone of the two cytotypes. Within the mixed populations no triploid plant and no evidence for gene flow between cytotypes were found, despite widely overlapping flowering periods. The two cytotypes can be distinguished on the basis of morphological traits and enzymatic gene pools. The congruence of morphological and allozymic variation with chromosome numbers suggests a secondary contact between the two cytotypes with limited gene flow between them. The origin and persistence of the parapatric distribution are discussed. [less ▲]

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See detailPercolation as a model for informetric distributions: fragment size distribution characterised by Bradford curves
Bogaert, Jan ULg; Rousseau, R; Van Hecke, P

in Scientometrics (2000), 47(2), 195-206

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See detailProgress in Arabidopsis genome sequencing and functionnal genomics.
Wambutt, R.; Portetelle, Daniel ULg; Vandenbol, Micheline ULg et al

in Journal of Biotechnology (2000), 78

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See detailEurojust ou Ministère public européen : Un choix de politique criminelle
Flore, Daniel ULg

in Agon (2000), 28

Les autorités nationales ne sont plus en mesure d'appréhender de façon adéquate les phénomènes criminels qui dépassent les frontières d'un Etat membre.

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See detailBooklist 1999
Pirenne, Christophe ULg

in Popular Music (2000), 19(3), 403-434

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See detailAutour de Stavelot-Malmedy (VIIe-IXe siècles)
George, Philippe ULg

in Publications de la Section Historique de l'Institut Royal Grand-Ducal de Luxembourg (2000)

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See detailSignificance of random illite-vermiculite mixed layers in Pleistocene sediments of the northwestern Atlantic Ocean
Vanderaveroet, P.; Bout-Roumazeilles, V.; Fagel, Nathalie ULg et al

in Clay Minerals (2000), 35(4), 679-691

The clay mineralogy of Pleistocene sediments of eleven sediment cores at three ODP sites from 30 degrees N to 60 degrees N northwestern Atlantic Ocean has been investigated. The sediments are ... [more ▼]

The clay mineralogy of Pleistocene sediments of eleven sediment cores at three ODP sites from 30 degrees N to 60 degrees N northwestern Atlantic Ocean has been investigated. The sediments are characterized by the presence of random illite-vermiculite mixed layers (I-V) (up to 32% of the clay mineral assemblage). The I-V clays are much more abundant during interglacial periods than during glacial ones. They are attributed to detrital supply through erosion of high-latitude continental areas from which they are derived mainly from chemical weathering of micaceous phyllosilicates. Their spatial distribution and the specific conditions for their formation through weathering suggest that I-V mixed layers are mainly derived from the Canadian Shield. They were transported From their source to marine deposition areas by rivers, deep water masses or nepheloid layers. Due to the specific conditions required For the Formation of I-V, its occurrence and abundance are used as a palaeoclimate and palaeocirculation proxy for northwestern Atlantic Pleistocene sediment. [less ▲]

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See detailJuvenile Nephropathy in a Boxer, a Rottweiler, a Collie and an Irish Wolfhound
Peeters, Dominique ULg; Clercx, Cécile ULg; Michiels, L. et al

in Australian Veterinary Journal (2000), 78(3), 162-5

Juvenile nephropathy was diagnosed in a Boxer, a Rottweiler, a Collie and an Irish Wolfhound dog, each presenting with signs compatible with chronic renal failure. The diagnosis in each case was based on ... [more ▼]

Juvenile nephropathy was diagnosed in a Boxer, a Rottweiler, a Collie and an Irish Wolfhound dog, each presenting with signs compatible with chronic renal failure. The diagnosis in each case was based on the presence of persistence of poorly differentiated tissue (immature glomeruli and/or tubules, persistent mesenchyme) on histopathologic examination. Although juvenile nephropathy has been reported in many breeds of dog, this is the first report of the condition in the Collie and the Irish Wolfhound and only the second description in the Boxer and the Rottweiler. The possibility of an inherited origin of the condition in these four breeds is at present unknown. [less ▲]

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See detailEffet de l’ammoniac sur la fibre C impliquée dans le réflexe de la toux chez le porc
Moreaux, B.; Nemmar, R.; Gustin, Pascal ULg

in Journées de la Recherche Porcine en France (2000), 32

The effect of ammonia on the C-fibre which is involved in the citric acid induced coughing reflex was assessed. The piglets were exposed during a period of 24 hours or 4 days to a concentration of 15 or ... [more ▼]

The effect of ammonia on the C-fibre which is involved in the citric acid induced coughing reflex was assessed. The piglets were exposed during a period of 24 hours or 4 days to a concentration of 15 or 30 ppm ammonia in an inhalation chamber . During this challenge, the animais underwent cough induction tests at two days intervals. Another group was exposed to ammonia (30 ppm) for 48 hours, after this period, substance P was assayed in liquids collected from broncho-alvealor and tracheal washings (BAL and TAL) and in tracheal and airway mucosa . Ammonia (30 ppm) induced an inhibition 0f the coughing reflex in pigs. The minimum period of exposure necessary to provoke this effect was 48 hours. The same ammonia concentration aiso induced o significant increase in substance P concentrations in BAL and TAL and a significant decrease in concentrations of the tracheal mucosa. We conclude that ammonia at o concentration of 30 ppm inhibits the citric acid induced coughing reflex. The effect was partly mediated by the release of substance P from the C-fibre. [less ▲]

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See detailAffections musculaires et intolrance à l'effort. 1- Pathogénie et approche diagnostique
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical ... [more ▼]

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical diagnosis (is the horse suffering from rhabdomyolysis or not ?) and the aetiology (what is/are the cause(s) of the condition ?) and also to provide an effective treatment [less ▲]

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See detailInfo-congres. L'etude "MIRACL" ou "Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering".
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(12), 1064-6

The results of the "MIRACL" trial ("Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering") were presented at the recent annual meeting of the American Heart Association in New Orleans last ... [more ▼]

The results of the "MIRACL" trial ("Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering") were presented at the recent annual meeting of the American Heart Association in New Orleans last November 2000. This study demonstrates that atorvastatin, at a daily dose of 80 mg starting within the first 24 to 96 hours after an acute coronary event (unstable angina or non-Q-wave acute myocardial infarction) and maintained for 4 months, improves the cardiovascular prognosis by decreasing the combined risk of death (any cause), nonfatal myocardial infarction, resuscitated cardiac arrest and worsening angina with new objective evidence of ischemia requiring urgent hospitalization (-16% versus placebo, p < 0.05). [less ▲]

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See detailLe controle glycemique chez le patient diabetique. Recommandations apres les etudes DCCT et UKPDI.
Paquot, Nicolas ULg; Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (2000), 55(5), 372-5

Diabetes mellitus is a chronic disorder characterized by microvascular and cardiovascular complications that substantially increase the morbidity and mortality associated with the disease. Several studies ... [more ▼]

Diabetes mellitus is a chronic disorder characterized by microvascular and cardiovascular complications that substantially increase the morbidity and mortality associated with the disease. Several studies showed the association between the complications of diabetes and elevated blood glucose levels. Clinical trials have also demonstrated that treatment that lowers blood glucose reduces the risks of diabetic complications (mainly microvascular complications). The control of diabetes is assessed by frequent measurements of HbA1c. A reasonable goal in type 1 diabetes is a value of HbA1c < or = 7.2%. In type 2 diabetes, the optimal goal is a value of HbA1c < or = 6.5%, but a value < or = 8% seems to be an acceptable goal in these patients. [less ▲]

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See detailLa prescription de l'action publique
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2000)

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See detailMedium-size droplets of methyl ricinoleate are reduced by cell-surface activity in the γ-decalactone production by Yarrowia lipolytica
Waché, Y.; Bergmark, K.; Courthaudon, J.-L. et al

in Letters in Applied Microbiology (2000), 30(3), 183-187

Size of methyl ricinoleate droplets during biotransformation into γ-decalactone by Yarrowia lipolytica was measured in both homogenized and non-homogenized media. In non-homogenized but shaken medium ... [more ▼]

Size of methyl ricinoleate droplets during biotransformation into γ-decalactone by Yarrowia lipolytica was measured in both homogenized and non-homogenized media. In non-homogenized but shaken medium, droplets had an average volume surface diameter d 32 of 2.5 μm whereas it was 0.7 μm in homogenized and shaken medium. But as soon as yeast cells were inoculated, both diameters became similar at about 0.7 μm and did not vary significantly until the end of the culture. The growth of Y. lipolytica in both media was very similar except for the lag phase which was lowered in homogenized medium conditions. [less ▲]

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See detailPreventie van postmenopauzale osteoporose
Reginster, Jean-Yves ULg; Halkin, V

in De agenda Gynaecologie (2000), 19

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See detailRelative impact of a seagrass bed and its adjacent epilithic algal community in consumer diets
Lepoint, Gilles ULg; Nyssen, Fabienne ULg; Gobert, Sylvie ULg et al

in Marine Biology (2000), 136

The aim of this work was to identify and compare, using nitrogen and carbon stable isotope data, the food sources supporting consumer communities in a Mediterranean seagrass bed (Gulf of Calvi, Corsica ... [more ▼]

The aim of this work was to identify and compare, using nitrogen and carbon stable isotope data, the food sources supporting consumer communities in a Mediterranean seagrass bed (Gulf of Calvi, Corsica) with those in an adjacent epilithic algal dominated community. Isotopic data for consumers are not significantly different in the two communities. Particulate matter and algal material (seagrass epiflora and dominant epilithic macroalgae) appear to be the main food sources in both communities. Generally, the 13C of animals suggests that the seagrass Posidonia oceanica (L.) Delile represents only a minor component of their diet or of the diet of their prey, but the occurrence of a mixed diet is not excluded. P.oceanica dominates the diet of only of few species, among which holothurians appear as key components in the cycling of seagrass material. [less ▲]

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See detailNon-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss.
Luyckx, Françoise ULg; Lefebvre, Pierre ULg; Scheen, André ULg

in Diabètes & Métabolism (2000), 26(2), 98-106

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance, and is now considered as one of the commonest liver diseases in western countries. It is frequently associated with ... [more ▼]

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance, and is now considered as one of the commonest liver diseases in western countries. It is frequently associated with severe obesity, especially abdominal adiposity, and is intimately related to various clinical and biological markers of the insulin resistance syndrome. Especially, both the prevalence and the severity of liver steatosis are related to male sex, body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. A substantial weight loss following gastroplasty is accompanied by a marked reduction in the prevalence and the severity of the various biological abnormalities of the metabolic syndrome and, concomitantly, by an important regression of liver steatosis in most obese patients. However, in some patients, this rapid and drastic weight loss may result in a mild increase in inflammatory lesions (hepatitis), despite the regression of steatosis, which might result from the rapid mobilization of fatty acids or cytokines from adipose tissue, especially visceral fat. The intimate relationship between NASH and obesity leads to the concept that NASH may be considered as another disease of affluence, as is the insulin resistance syndrome and perhaps being part of it. [less ▲]

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See detailInvolvement of acyl coenzyme A oxidase isozymes in biotransformation of methyl ricinoleate into γ-decalactone by Yarrowia lipolytica
Waché, Y.; Laroche, C.; Bergmark, K. et al

in Applied and Environmental Microbiology (2000), 66(3), 1233-1236

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes ... [more ▼]

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes (POX1 through POX5) (H. Wang et al., J. Bacteriol. 181:5140-5148, 1999). Here, these mutants were studied for lactone production. Monodisrupted strains produced similar levels of lactone as the wild-type strain (50 mg/liter) except for Δpox3, which produced 220 mg of γ-decalactone per liter after 24 h. The Δpox2 Δpox3 double-disrupted strain, although slightly affected in growth, produced about 150 mg of lactone per liter, indicating that Aox2p was not essential for the biotransformation. The Δpox2 Δpox3 Δpox5 triple- disrupted strain produced and consumed lactone very slowly. On the contrary, the Δpox2 Δpox3 Δpox4 Δpox5 multidisrupted strain did not grow or biotransform methyl ricinoleate into γ-decalactone, demonstrating that Aox4p is essential for the biotransformation. [less ▲]

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See detailProbing Organization and Structural Characteristics of Alkanethiols Adsorbed on Gold and of Model Alkane Compounds through their Valence Electronic Structure: an Ultraviolet Photoelectron Spectroscopy Study
Duwez, Anne-Sophie ULg; Pfister-Guillouzo, G.; Delhalle, Joseph et al

in Journal of Physical Chemistry B (2000), 104

In this paper we report an ultraviolet photoelectron spectroscopy (UPS) study of saturated alkane chains in various configurations and conformations. The dependence of the valence spectra on molecular ... [more ▼]

In this paper we report an ultraviolet photoelectron spectroscopy (UPS) study of saturated alkane chains in various configurations and conformations. The dependence of the valence spectra on molecular structure characteristics has been assessed by comparing the results obtained from n-alkanethiol, R,ö-alkanedithiol, and R-cycloalkyl-ö-alkanethiol monolayers adsorbed on gold, and from gas-phase model alkane compounds. The differences between the spectra reflect directly the structural changes induced in the electronic structure of the alkane chains. We have determined the type of folding sequences adopted in a 1,12-dodecanedithiol monolayer. Angular dependent measurements and investigations on the photoelectron attenuation length have evidenced very fine structural differences between films obtained on deposited gold films, annealed gold films, and gold single crystals [less ▲]

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See detailMolecular diversity of Microcystis strains (Cyanophyceae, Chroococcales) based on 16S rDNA sequences
LEPERE, Claire ULg; Wilmotte, Annick ULg; Meyer, Barbara

in Systematics and Geography of Plants (2000), 70

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These ... [more ▼]

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These sequences appear very similar to each other and to those of 71 Microcystis strains from four continents available in the databases. This great genotypic homogeneity, as measured by 16S rDNA sequence similarity (334 characters), is contrasting with the conspicuous morphological differences observed for the studied strains. [less ▲]

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See detailRecombinant prolactin Receptor Extracellular Domain of Rainbouw trout (Oncorhynchus mykiss): subcloning, preparation and characterization
Sandowski, Y.; Cohen, Y.; Le Rouzic, P. et al

in General and Comparative Endocrinology (2000), 118

The cDNA of the extracellular domain of rainbow trout (Oncorhynchus mykiss) prolactin receptor (trPRLR-ECD) was cloned in the prokaryotic expression vector pMON to enable its expression in Escherichia ... [more ▼]

The cDNA of the extracellular domain of rainbow trout (Oncorhynchus mykiss) prolactin receptor (trPRLR-ECD) was cloned in the prokaryotic expression vector pMON to enable its expression in Escherichia coli after induction with nalidixic acid. The bacterially expressed trPRLR-ECD protein, contained within the refractile body pellet, was solubilized in 4.5 M urea, refolded, and purified on a Q-Sepharose column, pH 8, by stepwise elution with NaCl. The bioactive monomeric 26-kDa fraction was eluted in 0.2 M NaCl, yielding 20 mg/2.5 L of induced culture. The purified protein was over 98% homogeneous, as shown by SDS-PAGE in the presence or absence of reducing agent and by chromatography on a Superdex column. Binding experiments using [125I]ovine placental lactogen (oPL) as a ligand revealed that human growth hormone (hGH), oPL, and ovine prolactin (oPRL) were the most effective competitors, with respective IC50 values of 1.32, 2.27, and 2.70 nM. Chicken (ch) PRL did not compete at all, and homologous trPRL was much less effective, with a corresponding IC50 value of 1826 nM. Gel-filtration was used to determine the stoichiometry of trPRLR-ECD's interaction with oPL, hGH, and oPRL. Only oPL yielded a 2:1 complex, whereas hGH and oPRL formed only 1:1 complexes, with excess trPRLR-ECD being seen at the initial 2:1 trPRLR-ECD:hGH or trPRLR-ECD:oPRL ratios. No studies were performed with chPRL because of its inability to compete with [125I]oPL or with trPRL because of its low affinity toward trPRLR-ECD. The present results agree with previous findings indicating, as in mammals, that homologous PRL interacts transiently with its receptor and suggest that transient homologous PRL-induced homodimerization of the receptor is sufficient to initiate a biological signal, despite the fact that, in classical binding experiments, only low specific binding can be detected. [less ▲]

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See detailLa place de l'intervention de Ross (autogreffe pulmonaire) dans la chirurgie de la valve aortique
RADERMECKER, Marc ULg; GRENADE, Thierry ULg; Gach, J. et al

in Revue Médicale de Liège (2000), 55(1), 35-8

The pulmonary autograft operation consists of an aortic replacement using the autologous pulmonary valve. The pulmonary valve is substituted by a cryopreserved pulmonary homograft. This operation is in ... [more ▼]

The pulmonary autograft operation consists of an aortic replacement using the autologous pulmonary valve. The pulmonary valve is substituted by a cryopreserved pulmonary homograft. This operation is in fact a delicate double valve replacement whose benefits are linked to the viability of the new aortic substitute. The pulmonary autograft has superb hemodynamic features and very low thrombogenicity. The report of a selected observation offers the occasion of defining the current indications of this operation in aortic valve surgery. [less ▲]

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See detailQuantitative bacterial cultures and cytological examination of bronchoalveolar lavage specimens in the diagnosis of lower respiratory tract disease in dogs: a retrospective study of 48 cases.
Peeters, Dominique ULg; McKierman, B.; Weisiger, R. et al

in Journal of Veterinary Internal Medicine (2000), 14(5), 534-541

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective ... [more ▼]

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective study was conducted to determine the usefulness of quantitative aerobic cultures and Gram stain intracellular bacteria counts from bronchoalveolar lavage (BAL) specimens in dogs in diagnosing lower respiratory tract infection (LRTI) and to determine whether chronic bronchitis is associated with marked bacterial growth in dogs. The threshold determined to define clinically relevant bacterial growth was 1.7 x 10(3) colony-forming units per milliliter of BAL fluid. We used this threshold and found that diagnostic sensitivity and specificity were 86% and 100%, respectively. With a threshold for infection of >2 intracellular bacteria observed in any of 50 fields, microscopic examination of Gram stain BAL preparations had a sensitivity of 71% and a specificity of 97% in establishing LRTI. There was a high correlation between bacterial morphology on BAL Gram stain and bacterial cultures. Combining the results of intracellular bacteria counts from the BAL Gram stain with those from the quantitative cultures, the sensitivity in diagnosing LRTI was 87% and the specificity was 97%. BAL quantitative cultures as well as quantitating intracellular bacteria on Gram stain BAL cytology were revealed to be useful in identifying LRTI in dogs. Chronic bronchitis does not appear to be associated with marked bacterial growth in dogs. [less ▲]

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See detailLes brulis, un outil de gestion de la faune en region Afrique inter-tropicale.
Cornelis, D.; Lungren, C.; Ouedraogo, Mohamar moussa ULg et al

in Parcs & Réserves (2000), 55(3-4),

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See detailThe internet: A global telecommunications solution?
Mathy, Laurent ULg; Edwards, C.; Hutchison, D.

in IEEE Network (2000), 14(4), 46--57

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See detailLa contamination de l'eau et des aliments par les virus pathogènes pour l'homme
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (2000), 144

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See detailEclipse totale du 11 août 1999 et évolution de la basse ionosphère
Delcourt, J. J.; Jodogne, J.-C.; Biémont, Emile ULg

in Ciel et Terre (2000), 116(1), 6-7

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See detailLes caractéristiques de l'enseignant expert
Piéron, Maurice ULg; Delfosse, Catherine ULg; Ledent, Maryse ULg et al

in Revue de l'Education Physique (2000), 40(4), 173-180

L'étude fait partie du projet de recherche 157/1997 de la Communauté française, projet confié au service de Pédagogie des activités physiques et sportives de l'Université de Liège. D'autres aspects de ... [more ▼]

L'étude fait partie du projet de recherche 157/1997 de la Communauté française, projet confié au service de Pédagogie des activités physiques et sportives de l'Université de Liège. D'autres aspects de cette recherche furent présentés dans les numéros 1, 2 et 3 du volume 40 de la Revue de l'Education Physique. [less ▲]

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See detailLe principe de precaution et l'obligation d'action medicale
Foidart, Jean-Michel ULg

in Bulletin de l'Académie Nationale de Médecine (2000), 184(5), 937-43943-4

Since Antiquity, medicine has been based upon the principle of prudence. In recent years, the principle of precaution has stolen over the medical conscience and has especially been forced on doctors under ... [more ▼]

Since Antiquity, medicine has been based upon the principle of prudence. In recent years, the principle of precaution has stolen over the medical conscience and has especially been forced on doctors under pressure from a Society searching for a new Holy Grail; the utopia of zero risk and the fear for magical power of an omnipotent medicine. The principle of precaution should be capable of warding off all these evils of techno-scientific progress applied to Health. Thus, in a few years, a new norm has established itself first for the environment but which has today extended to the domain of medical decisions. It is essential that the medical authorities attract the attention of politics and of the judiciary to the dangers of blindly transposing the principle of precaution in ecology to the world of medicine. The risks of deviation are numerous, the eventual perverse effects would be detrimental to patients and health security would be endangered by paralysis and conservatism. Medicine is neither the Art of Curing nor the Art of not Harming, ... it is the Art of Caring! ... [less ▲]

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See detailLes composantes d'un management efficace dans le cadre des organisations sportives
Cloes, Marc ULg

in Sport (2000), 172

L'objectif de cet article consiste à réaliser une synthèse des notions abordées par les auteurs du colloque "Initiatives en matière de management du sport" et de fournir un outil permettant aux ... [more ▼]

L'objectif de cet article consiste à réaliser une synthèse des notions abordées par les auteurs du colloque "Initiatives en matière de management du sport" et de fournir un outil permettant aux responsables d'organisatons sportives de s'engager dans une auto-analyse des structures dont ils ont la charge. Pour rappel, le management se définit comme l'action de gérer, de diriger, d'assurer le succès d'une organisation. [less ▲]

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See detailExample of application of the new strategy proposed for the validation of chromatographic bioanalytical methods
Chapuzet, E.; Mercier, N.; Bervoas-Martin, S. et al

in STP Pharma Pratiques (2000), 10(2), 79-101

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See detailEpidemiologie, physiopathologie et traitement d'une affection frequente: tinea pedis.
Lambert, Jean-Luc ULg; Richert, Bertrand ULg; Dezfoulian, Bita ULg et al

in Revue Médicale de Liège (2000), 55(3), 161-8

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly ... [more ▼]

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly responsible for the increase of cases of tinea pedis as dermatophytes grow preferentially in warm and humid environments. The clinical aspect is affected by several factors such as the host reaction to the infection, the virulence of the infective strain, species, and some local and environmental factors. If a dermatophytosis is suspected, it is mandatory to validate the provisional diagnosis by demonstration of the fungus (by culture or/and microscopic examination) to avoid useless and expensive treatments. The new antifungal molecules are very effective, well tolerated and allow short course of therapy improving the compliance of the patient in clinical practice. Relapse of tinea pedis is very common but could be avoided by several simple preventive measures of hygiene. [less ▲]

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See detailContribution à la connaissance des Chrysopidae de Belgique : bilan des captures réalisées à Gembloux.
Mignon, Jacques ULg; Bozsik, Andras; Gaspar, Charles

in Notes Fauniques de Gembloux (2000), 41

Douze espèces de Chrysopidae furent identifiées: H. elegans, N. flava, N. pallida, Ch. ciliata, Ch. perla, Ch. pallens, D. flavifrons, D. prasina, D. ventralis, T. gracilis, Ch. carnea et C. albolineata ... [more ▼]

Douze espèces de Chrysopidae furent identifiées: H. elegans, N. flava, N. pallida, Ch. ciliata, Ch. perla, Ch. pallens, D. flavifrons, D. prasina, D. ventralis, T. gracilis, Ch. carnea et C. albolineata. Une espèce, Tjederina ventralis est nouvelle pour la faune belge. [less ▲]

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See detailLes souches pathogènes d'Escherichia coli chez les chiens et chats : II) Données cliniques et bactériologiques sur les souches entéropathogènes
Mainil, Jacques ULg; Janssen, L.; Charlier, G. et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailEnantioselective Syntheses and Absolute Configuration of the Ladybird Defence Alkaloids (+)-Calvine and (+)-2-Epicalvine
Laurent, Pascal ULg; Braekman, Jean-Claude; Daloze, Désiré

in European Journal of Organic Chemistry (2000), 11

Enantiomerically pure (+)-calvine (1a) and (+)-2-epicalvine (Ib), two piperidine alkaloids isolated from ladybird beetles of the genus Calvia (Coccinellidae), were synthesized by two different strategies ... [more ▼]

Enantiomerically pure (+)-calvine (1a) and (+)-2-epicalvine (Ib), two piperidine alkaloids isolated from ladybird beetles of the genus Calvia (Coccinellidae), were synthesized by two different strategies starting from (-)-2,3,6,7,8,8a-hexahydro-3-phenyl-5H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile (2). The key steps of these syntheses are the stereocontrolled formation of an asymmetric centre a to the nitrogen atom of 2 and the subsequent introduction of the methoxycarbonylmethyl substituent at the u'-position. Comparison of the optical rotations of the synthetic benzoates (12a) and (12b) with those of the corresponding benzoates derived from the natural compounds has revealed the absolute configuration of (+)-calvine to be (2S,6S) and that of (+)-2-epicalvine to be (2R,6S). [less ▲]

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See detailMotivations et apports d'une prise en charge ambulatoire pluridisciplinaire de la santé des adolescents
Bourguignon, Jean-Pierre ULg; Grignard, Sophie ULg; Glowacz, Fabienne ULg et al

in Bulletin d'Education du Patient à sa Maladie (2000), 19(3), 126-129

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils ... [more ▼]

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils consultent peu à ce sujet. En particulier, ils évoquent rarement les aspects psychosociaux des problèmes auxquels ils sont confrontés. Ils fonctionnent dans le clivage entre somatique et psychologique bien que ces deux aspects soient indissociables. Les adolescents sont souvent amenés en consultation par d’autres, dont les parents. Un travail d’identification de la demande réelle de l’adolescent est donc nécessaire pour que celui-ci puisse se mobiliser vers une prise en charge. La confidentialité est cruciale de même que le respect de l’adolescent, ainsi que la reconnaissance de ses craintes et des limites qu’il met à l’accès aux informations par l’anamnèse et l’examen clinique. Il appartient au médecin de lire la demande de l’adolescent dans un double registre, à la fois somatique et psychique et de resituer cette demande dans le contexte de vie particulier à l’adolescent. Aussi, la lecture de la demande intégrera non seulement les problèmes invoqués par l’adolescent mais aussi ceux relevés par l’anamnèse et l’examen clinique. Une telle lecture peut prendre du temps pour les intervenants de santé mais aussi pour l’adolescent, avant qu’il n’aboutisse à l’émergence de sa demande et, dès lors, à une demande de prise en charge. Celle-ci devra parfois faire appel à une équipe spécifique et pluridisciplinaire telle que celle où collaborent les auteurs du présent article, au Centre de Santé de l’Adolescent à Liège. [less ▲]

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See detailDerived Categories for Functional Analysis
Prosmans, Fabienne ULg

in Publications of the Research Institute for Mathematical Sciences (2000), 36(1), 19-83

We study the homological algebra of the category of locally convex topological vector spaces from the point of view of derived categories.

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See detailLandscape fragmentation assessment using a single measure.
Bogaert, Jan ULg; Van Hecke, P; Salvador-Van Eysenrode, D et al

in Wildlife Society Bulletin (2000), 28(4), 875-881

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See detailOppositions locales et dynamiques d'environnementalisation
Mormont, Marc ULg; Bertrand, Anne

in Espaces et Sociétés (Paris, France) (2000), (101-102), 93-112

Local conflicts provoke collective action that through new coalitions induce reformulations of the problems and elarge scope and scaling of environmental problems. These processes are called ecologization ... [more ▼]

Local conflicts provoke collective action that through new coalitions induce reformulations of the problems and elarge scope and scaling of environmental problems. These processes are called ecologization dynamics and are going to transform environmental politics. [less ▲]

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See detailAutomatisation d'un banc de répartition pour buses de pulvérisation
Lebeau, Frédéric ULg; Hamza, Elies; Destain, Marie-France ULg

in Cahiers Agricultures (2000)

Les bancs de répartition constituent l'élement de base permettant de tester la sensibilité de la distribution transversale des buses de pulvérisation aux différents paramètres de fonctionnement. L'article ... [more ▼]

Les bancs de répartition constituent l'élement de base permettant de tester la sensibilité de la distribution transversale des buses de pulvérisation aux différents paramètres de fonctionnement. L'article présente un banc d'essai conforme à la norme ISO 5682/1 qui permet une lecture automatisée des différentes grandeurs (pression, débit, volume recueilli). [less ▲]

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See detailLe développement folliculaire chez la vache. 2. Mécanismes hormonaux au cours du cycle et du postpartum.
Drion, Pierre ULg; Beckers, Jean-François ULg; Derkenne, F. et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailLa douleur pelvienne chez le patient oncologique
Jansen, Nicolas ULg; Nickers, Philippe ULg; Devoghel, Jean-Claude ULg

in Oncologie (2000), 2(4), 187-200

Pelvic pain is a common problem in the general population. In cancer patients this pain can be secondary to tumor activity or recent tumor related interventions (surgery, radiotherapy, chemotherapy). On ... [more ▼]

Pelvic pain is a common problem in the general population. In cancer patients this pain can be secondary to tumor activity or recent tumor related interventions (surgery, radiotherapy, chemotherapy). On the other hand cancer patients can also suffer from not cancer related pain. Cancer related pain is often chronic. Whatever the cause of this pain, an important psychological factor is often present, if not attributing to the pathogenesis of the pain, then as an secondary effect from the pain. Managing pelvic pain requires knowledge of the regional anatomy. A general overview is given of the approach to an oncological patient presenting with pelvic pain. Three different possibilities are discussed: (1) pain in a patient without a presently known pelvic or abdominal malignancy, (2) pain in a patient treated recently for a tumor in the pelvic area or lower abdomen, (3) pain in an so far untreated patient with a known tumor. Finally an overview of treatment options is presented. [less ▲]

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See detailPharma clinics. Comment je traite ... un trouble de la kaliémie
Neven, Ingrid; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2000), 55(1), 4-7

The treatment of dyskalemia must be primarily etiological and later symptomatic. When moderate but significant hypokalemia exists (K < 3 mmol/l or 3.5 mmol/l with cardiac disease), oral K supplements must ... [more ▼]

The treatment of dyskalemia must be primarily etiological and later symptomatic. When moderate but significant hypokalemia exists (K < 3 mmol/l or 3.5 mmol/l with cardiac disease), oral K supplements must be given. The intravenous route must be reserved for emergency or impossible oral administration. Acute and severe hyperkalemia (K > 7 mmol/l) must be first corrected by different intravenous measures with secondary oral intervention. In chronic and/or moderate hyperkalemia (K > 5.5 mmol/l), the oral route for treatment is prefered. In any case, the research of the cause (mainly drug induced) is fundamental. [less ▲]

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See detailL'influence de l'article 6 de la Convention européenne des droits de l'homme sur la procédure pénale belge
Jacobs, Ann ULg; Berbuto, Sandra

in Revue de Droit International et de Droit Comparé (2000)

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See detailUnawareness of illness in chronic schizophrenia and its relationship to structural brain measures and neuropsychological tests
Laroi, Frank ULg; Fannemel, M.; Ronneberg, U. et al

in Psychiatry Research : Neuroimaging Section (2000), 100(1), 49-58

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See detailL'écriture en chantier. Une brochure destinée aux enseignants du secondaire
Baye, Ariane ULg; Denooz, Régine

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), 7-8

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See detailLe virus de la varicelle et du zona dans le système nerveux : retraite silencieuse ou guérilla permanente ?
Rentier, Bernard ULg; Sadzot-Delvaux, Catherine ULg

in Virologie (2000), 4(3), 207-216

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features : chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological ... [more ▼]

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features : chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological aspects of these diseases such as complications of chicken pox, viral latency in sensory gan-glia and reactivation as shingles with concurrent and at times subsequent prolonged pain, are the sequels of the invasion of the peripheral nervous system during primary infection. Prevention is achieved by vaccination with a live attenuated virus strain and therapy calls for specific antiviral agents. In many respects, VZV behaves differently from close relatives. In particular, viral latency in the nervous system is quite different from that of other Herpesviri-dae. The recent discovery of the expression and accumulation of some viral regulatory proteins during latency, although VZV latency had always been considered silent, as well as the demonstration that these proteins are immu-nogenic are opening new avenues to investigate the mechanisms of VZV latency and the immune control of VZV reactivation. [less ▲]

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See detailNumerical discretization of rotated diffusion operators in ocean models
Beckers, Jean-Marie ULg; Burchard, Hans; Deleersnijder, Eric et al

in Monthly Weather Review (2000), 128(8), 2711-2733

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on ... [more ▼]

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on the so-called z-coordinate system is presented. The authors then focus exclusively on the dynamically passive tracers and analyze some different approaches to the numerical discretization. Monotonic schemes are designed but are found to be rather complex, while simpler, linear schemes are shown to produce unphysical undershooting and overshooting. It is suggested that the choice of an appropriate discretization method depends on the importance of the rotated diffusion in a given simulation, whether the field to be diffused is dynamically active or not. [less ▲]

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See detailTEP et tumeurs endocrines
Rigo, Pierre ULg; Belhocine, Tarik; Hustinx, Roland ULg et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2000), 24(5), 275-282

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les ... [more ▼]

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les tumeurs neuroendocrines, gastroentéropancréatiques et carcinoïdes, sont également analysées. Habituellement, les tumeurs différenciées ayant une faible activité métabolique et proliférative, elles ne fixent que peu le FDG. Dans l'évaluation des tumeurs endocrines, la TEP au FDG n'intervient en général pas en première intention mais elle joue un rôle complémentaire d'autres scintigraphies spécifiques. [less ▲]

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See detailLégislation et exercice de l'entomologie en Région wallonne
Fagot, Jean ULg; Dethier, Michel ULg

in Notes Fauniques de Gembloux (2000), 41

In Wallonia, a new law is in study to set up a better level of protection for the fauna and the flora, and that, in respect of the european spirit of Nature preservation. On the other hand, a lot of ... [more ▼]

In Wallonia, a new law is in study to set up a better level of protection for the fauna and the flora, and that, in respect of the european spirit of Nature preservation. On the other hand, a lot of territories are raised to different level of protection. The authors enumerate the consequences of the new act and European directives on the practice of the entomology in Wallonia. [less ▲]

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See detailLa compréhension des opérations additives et soustractives au travers de la résolution de problèmes arithmétiques : présentation des axes directeurs d'une thèse de doctorat en cours de préparation
Fagnant, Annick ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 117-132

Cette recherche fait l'objet d'une thèse de doctorat, présentée par l'auteur du présent article dans le cadre d'un mandat d'aspirant au F.N.R.S. Le projet est encadré par une comité de thèse constitué de ... [more ▼]

Cette recherche fait l'objet d'une thèse de doctorat, présentée par l'auteur du présent article dans le cadre d'un mandat d'aspirant au F.N.R.S. Le projet est encadré par une comité de thèse constitué de Marcel Crahay (directeur de thèse, ULg), de Jacqueline Beckers (ULg) et de Lieven Verschaffel (KUL). A l'heure actuelle, l'état d'avancement des travaux ne permet pas encore de présenter les résultats des investigations. Le présent article vise à donner un aperçu des différents axes sur lesquels porte l'étude. [less ▲]

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See detailPharma-clinics. Le medicament du mois. Le glimepiride (Amarylle).
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(3), 184-6

Glimepiride, commercialized in Belgium under the trade name of Amarylle by Aventis, is a new sulphonylurea compound which is indicated in the treatment of type 2 diabetes, after diet and exercise failure ... [more ▼]

Glimepiride, commercialized in Belgium under the trade name of Amarylle by Aventis, is a new sulphonylurea compound which is indicated in the treatment of type 2 diabetes, after diet and exercise failure. It is available as 2 mg tablets. The initial doses is 1 mg, to be progressively increased up to 4 mg per day, if necessary, with a maximal daily dose of 6 mg. It is recommended to take glimepiride once a day, with the first main meal. Because of a particular binding of this sulphonylurea to the B cells of Langerhans pancreatic islets and, perhaps, of the presence of some extrapancreatic effects, both hypoglycaemic risk and circulating plasma insulin levels are lower with glimepiride than with glibenclamide, the reference sulphonylurea agent used in comparative clinical trials. [less ▲]

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See detailHigh production of SPARC/osteonectin/BM-40 in mouse metastatic B16 melanoma cell lines
Kato, Y.; Frankenne, F.; Noël, Agnès ULg et al

in Pathology Oncology Research (2000), 6(1), 24-26

Abstract Production of SPARC/osteonectin/BM-40 was determined in mouse B16 melanoma clones BL6 and F10 (high metastatic) and F1 (low metastatic). SPARC was produced greater amount in BL6 and F10 than in ... [more ▼]

Abstract Production of SPARC/osteonectin/BM-40 was determined in mouse B16 melanoma clones BL6 and F10 (high metastatic) and F1 (low metastatic). SPARC was produced greater amount in BL6 and F10 than in F1 cells, showing a good agreement with their metastatic potentials. Moreover, SPARC production was not influenced by culture pH, even in the acidic conditions (= pH 5.9). Although tumor tissues show often low pH due to excessive amount of acidic metabolites such as lactate, most studies have been done in neutral pH. High SPARC production in the acidic medium, therefore, is thought to be an important potential for tumor invasive behaviour. [less ▲]

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See detailThe increase of the ionospheric activity as measured by GPS
Warnant, René ULg; Pottiaux, Eric

in Earth, Planets, and Space [=EPS] (2000), 52(11), 1055-1060

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See detailMission du team belge au Kosovo: science et justice à la rencontre du drame humain. Premiers résultats
BEAUTHIER, Jean-Pol; Boxho, Philippe ULg; CREVECOEUR, Jean-Marie et al

in Revue de Biométrie humaine et d'Anthropologie (2000)

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See detailDynamics and three-dimensional localization of ribosomal RNA within the nucleolus.
Thiry, Marc ULg; Cheutin, T.; O'Donohue, M. F. et al

in RNA (New York, N.Y.) (2000), 6(12), 1750-61

Although rRNA synthesis, maturation, and assembly into preribosomal particles occur within the nucleolus, the route taken by pre-rRNAs from their synthetic sites toward the cytoplasm remains largely ... [more ▼]

Although rRNA synthesis, maturation, and assembly into preribosomal particles occur within the nucleolus, the route taken by pre-rRNAs from their synthetic sites toward the cytoplasm remains largely unexplored. Here, we employed a nondestructive method for the incorporation of BrUTP into the RNA of living cells. By using pulse-chase experiments, three-dimensional image reconstructions of confocal optical sections, and electron microscopy analysis of ultrathin sections, we were able to describe topological and spatial dynamics of rRNAs within the nucleolus. We identified the precise location and the volumic organization of four typical subdomains, in which rRNAs are successively moving towards the nucleolar periphery during their synthesis and processing steps. The incorporation of BrUTP takes place simultaneously within several tiny spheres, centered on the fibrillar centers. Then, the structures containing the newly synthesized RNAs enlarge and appear as compact ringlets disposed around the fibrillar centers. Later, they form hollow spheres surrounding the latter components and begin to fuse together. Finally, these structures widen and form large rings reaching the limits of the nucleoli. These results clearly show that the transport of pre-rRNAs within the nucleolus does not occur randomly, but appears as a radial flow starting from the fibrillar centers that form concentric rings, which finally fuse together as they progress toward the nucleolar periphery. [less ▲]

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See detailChemical changes and influences of rapeseed antinutritional factors on lamb physiology and performance. 3. Antinutritional factors in plasma and organs
Mabon, N.; Mandiki, S. N. M.; Derycke, G. et al

in Animal Feed Science & Technology (2000), 85(1-2), 111-120

The impact of a high level of rapeseed meal in the diet on the concentration of antinutritional factors in plasma and organs was studied in 66 Texel, Suffolk or crossbred lambs. From 1 month of age till ... [more ▼]

The impact of a high level of rapeseed meal in the diet on the concentration of antinutritional factors in plasma and organs was studied in 66 Texel, Suffolk or crossbred lambs. From 1 month of age till slaughter (132+/-21 days), they were fed ad libitum with concentrates containing 0% or 25% of rapeseed meal obtained either Samourai or Honk rapeseed varieties. Lambs were weaned at 88+/-8 days of age and 24+/-5 kg live weight. Blood and organ samples were taken fortnightly for the determination of antinutritional factors. In plasma and organs, the thiocyanate concentrations were systematically higher in the Samourai and Honk lots than in the control. After weaning, the SCN- concentration in plasma increased up to 490 mu mol l(-1) in the Samourai lot. The goitrogen 5-vinyl-1,3-oxazolidine-2-thione (5-VOT) was determined in muscle, organs (thyroid, liver, kidney and lung) and biological fluid (plasma). The 5-VOT was present only after the ingestion of rapeseed meal but not to the same extent for the two varieties. The Honk rapeseed meal induced a 5-VOT level significantly (p<0.05) higher in the target organs such as lung and thyroid than Samourai. Very low levels were found in muscle, liver, kidney, plasma and lung. (C) 2000 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailThe bushlike radiation of muroid rodents is exemplified by the molecular phylogeny of the LCAT nuclear gene.
Michaux, Johan ULg; Catzeflis, F.

in Molecular Phylogenetics & Evolution (2000), 17(2), 280-93

Phylogenetic relationships among 40 extant species of rodents, with an emphasis on the taxonomic sampling of Muridae and Dipodidae, were studied using sequences of the nuclear protein-coding gene LCAT ... [more ▼]

Phylogenetic relationships among 40 extant species of rodents, with an emphasis on the taxonomic sampling of Muridae and Dipodidae, were studied using sequences of the nuclear protein-coding gene LCAT (lecithin cholesterol acyl transferase). Analysis of 804 bp from the exonic regions of LCAT confirmed many traditional groupings in and around Muridae. A strong support was found for the families Muridae (represented by 29 species) and Dipodidae (5 species). Compared with Sciuridae, Gliridae, and Caviomorpha, the Dipodidae family appeared the closest relative of Muridae, confirming the suprafamilial Myodonta concept. Within the speciose family Muridae, the first branching leads to the fossorial Spalacinae and semifossorial Rhyzomyinae. The remaining components of Muridae appear as a polytomy from which are issued Sigmodontinae, Calomyscinae, Arvicolinae, Cricetinae, Mystromyinae, Nesomyinae, and some Dendromurinae (Steatomys and Dendromus). This phylogeny is interpreted as the result of a bushlike radiation at the end of the early Miocene, leading to emergence of most living subfamilies. The separation between three additional taxa, Murinae, Gerbillinae, and "Acomyinae" (which comprises the genera Acomys, Deomys, Uranomys, and Lophuromys), has occurred more recently from a common ancestor issued from the main basal radiation. As previously shown by other molecular studies, the vlei rats, Otomyinae, are nested within Old World Murinae. In the same way, the zokors, Myospalacinae, appear strongly nested within the hamsters, Cricetinae. Finally, we propose a sister group relationship between Malagasy Nesomyinae and south African Mystromyinae. [less ▲]

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See detailComment je traite.... De la pharmacologie speciale a la therapeutique medicale: plaidoyer pour un enseignement privilegiant l'apprentissage au raisonnement therapeutique, de la decision a la prescription.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 811-6

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important ... [more ▼]

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important step of the medical approach. Such a learning should occur progressively throughout the medical education, focusing, first, on the therapeutic reasoning ("why?") and, second, on the practical application leading to the prescription ("how?"). The medical student should learn the difficult task of integrating disease, drug and patient, in order to optimize the benefit/risk ratio, while being informed about new concepts such as "Evidence-Based Medicine" and pharmacoeconomics. [less ▲]

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See detailLa prise en charge de patients Alzheimer au stade débutant : Rôle d'un centre de jour
Adam, Stéphane ULg; Van der Linden, Martial ULg

in Rééducation Orthophonique (2000), 201

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