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See detailComparative immunohistochemical study of herpes-simplex and varicella-zoster infections
Nikkels, Arjen ULg; Debrus, S.; Sadzot-Delvaux, Catherine ULg et al

in Virchows Archiv. A : Pathological Anatomy and Histopathology (1993), 422(2), 121-126

Herpes simplex (HSV) and varicella-zoster (VZV) skin infections share so many histological similarities that distinguishing between them may prove to be impossible. We developed and characterized a new ... [more ▼]

Herpes simplex (HSV) and varicella-zoster (VZV) skin infections share so many histological similarities that distinguishing between them may prove to be impossible. We developed and characterized a new monoclonal antibody, VL8, IgG kappa isotype, directed to the VZV envelope glycoprotein gpI. Immunohistochemistry with VL8 appeared highly sensitive and specific on formalin-fixed paraffin-embedded biopsies and a clear-cut distinction between HSV and VZV infections was possible. The pattern of VL8 immunolabelling in VZV infections was strikingly different from that found in HSV infections studied with polyclonal antibodies to HSV I and II. Double immunolabelling revealed the VL8 positivity of sebaceous cells, endothelial cells, Mac 387-and CD68-positive monocyte-macrophages, and factor XIIIa-positive perivascular, perineural and interstitial dendrocytes. Intracytoplasmic VL8 labelling of endothelial cells and perivascular dendrocytes was found at the site of leukocytoclastic vasculitis. [less ▲]

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See detailL'angoisse minimaliste
Demoulin, Laurent ULg

in Indications. La Revue des Romans (1993), 1(50), 27-31

Description de quelques caractéristiques du roman français contemporain.

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See detailBrain Aromatase and the Control of Male Sexual Behavior
Balthazart, Jacques ULg; Foidart, Agnès ULg

in Journal of Steroid Biochemistry & Molecular Biology (1993), 44(4-6), 521-40

The activational effects of testosterone (T) on male copulatory behavior are mediated by its aromatization into estradiol. In quail, we have shown by stereotaxic implantation of steroids and metabolism ... [more ▼]

The activational effects of testosterone (T) on male copulatory behavior are mediated by its aromatization into estradiol. In quail, we have shown by stereotaxic implantation of steroids and metabolism inhibitors and by electrolytic lesions that the action of T and its aromatization take place in the sexually dimorphic medial preoptic nucleus (POM). The distribution and regulation of brain aromatase was studied in this species by product-formation assays measuring aromatase activity (AA) in microdissected brain regions and by immunocytochemistry (ICC). Aromatase-immunoreactive (ARO-ir) neurons were found in four brain regions: the POM, the septal region, the bed nucleus of the stria terminals (BNST) and the tuberal hypothalamus. ARO-ir cells actually outline the POM boundaries. ARO-ir material is found not only in the perikarya of neurons but also in the full extension of their cellular processes including the axons and the presynaptic boutons. This is confirmed at the light level by the demonstration of immunoreactive fibers and punctate structures in brain regions that are sometimes fairly distant from the closest ARO-ir cells. A lot of ARO-ir cells in the POM and BNST do not contain immunoreactive estrogen receptors (ER-ir) as demonstrated by double label ICC. These morphological data suggest an unorthodox role for the enzyme or the locally formed estrogens. In parallel with copulatory behavior, the preoptic AA decreases after castration and is restored by T to levels seen in sexually mature males. This probably reflects a change in enzyme concentration rather than a modulation of the activity in a constant number of molecules since the maximum enzymatic velocity (Vmax) only is affected while the affinity (Km) remains unchanged. In addition, T increases the number of ARO-ir neurons in POM and other brain areas suggesting that the concentration of the antigen is actually increased. This probably involves the direct activation of aromatase transcription as demonstrated by RT-PCR studies showing that aromatase mRNA is increased following T treatment of castrates. These activating effects of T seem to result from a synergistic action of androgenic and estrogenic metabolites of the steroid. The anatomical substrate for these regulations remains unclear at present especially in POM where ARO-ir cells do not in general contain ER-ir while androgen receptors appear to be rare based on both [3H] dihydrotestosterone autoradiography and ICC. Transynaptic mechanisms of control may be considered. A modulation of brain aromatase by catecholamines is also suggested by a few pharmacological studies.(ABSTRACT TRUNCATED AT 400 WORDS) [less ▲]

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See detailHIV-1 promoter activation following an oxidative stress mediated by singlet oxygen
Legrand, Sylvie ULg; Hoebeke, Maryse ULg; Vaira, Dolorès ULg et al

in Journal of Photochemistry and Photobiology B : Biology (1993), 17(3), 229-237

Various biological processes, such as photosensitization or inflammatory reactions, can generate singlet oxygen (O-1(2)) as one of the major oxidative species. Because this oxidant can be generated either ... [more ▼]

Various biological processes, such as photosensitization or inflammatory reactions, can generate singlet oxygen (O-1(2)) as one of the major oxidative species. Because this oxidant can be generated either extracellularly or intracellularly, it can cause severe damage to various biological macromolecules, even to those deeply embedded inside the cells such as DNA. Sublethal biological modifications induced by different DNA-damaging agents can promote various cellular responses initiated by the activation of various cellular genes and certain heterologous viruses. Since O-1(2) fulfils essential prerequisites for a genotoxic substance, we have examined the effects of an oxidative stress, mediated by this species, on cells harbouring a heterologous promoter-leader sequence derived from the human immunodeficiency virus type 1 (HIV-1). Our results demonstrate that HIV-1 long terminal repeat (LTR), integrated into the cellular I)NA of epithelial cells, can be transactivated following an oxidative stress mediated by O-1(2). In addition, using HIV-1 latently infected promonocytes or lymphocytes, it can be shown that virus reactivation can be induced through a sublethal dose of O-1(2) generated intracellularly. An extracellular generation of O-1(2) can promote a substantial lethal effect without HIV-1 reactivation. These data may be relevant to the understanding of the events converting a latent infection into a productive one and to the appearance of the acquired immune deficiency syndrome. [less ▲]

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See detailSobre a construção de porjetores ortogonais
Iemma, A. F.; Palm, Rodolphe ULg; Claustriaux, Jean-Jacques ULg

in Revista de Matemática e Estatìstica (1993), 11

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See detailMagnitudes des étoiles doubles.
Renson, Pierre ULg

in Ciel et Terre (1993), 109

Not Available

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See detailEfficient Immunoselection of Cytolytic Effectors with a Magnetic Cell Sorter
Jacobs, Nathalie ULg; Moutschen, Michel P; Boniver, Jacques ULg et al

in Research in Immunology (1993), 144(2), 141-50

This paper describes a rapid and efficient method for the sorting of in vitro activated cytolytic effectors cells. For cytotoxic assays, a large number of cells with conserved function must be rapidly ... [more ▼]

This paper describes a rapid and efficient method for the sorting of in vitro activated cytolytic effectors cells. For cytotoxic assays, a large number of cells with conserved function must be rapidly obtained. Immunomagnetic sorting was chosen because it is faster than flow cytometry sorting. The MACS system requires the use of paramagnetic beads of small diameter (100-150 nm), reputed to interfere minimally with cell function. In order to generate the cytolytic effectors, peripheral blood lymphocytes were cultivated in the presence of interleukin-2 (50 U/ml) and anti-CD3 monoclonal antibody (BMA030, 100 ng/ml) for 4 days. Cell separation was based on the membrane expression of the CD3 complex. The purity obtained for positive (CD3+) cell sorting with the MACS was higher than 95%. The purity of negative (CD3-) cell fraction was more variable, but further purification by flow cytometry rapidly yielded purity higher than 95%. Cytotoxic assays were performed against four target cell lines (K562, Daudi, HL60 and U937) and proliferation assays showed that both negatively and positively selected populations had conserved their function acquired during culture in the presence of anti-CD3 mAb and IL2. [less ▲]

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See detailEvaluation quantitative de l'érythème par colorimétrie. Effets de l'histamine de corticostéroïdes et d'extraits végétaux
Arrese Estrada, Jorge ULg; Nikkels, Arjen ULg; El Fekih, N. et al

in Journal d'Actualités Médicales Belges (1993), 5

L'évaluation de l'érythème est difficile et souvent aléatoire en clinique. Afin d'étudier la couleur des téguments, la colorimétrie est proposée depuis quelques années. Elle permet plus de rigueur. En ... [more ▼]

L'évaluation de l'érythème est difficile et souvent aléatoire en clinique. Afin d'étudier la couleur des téguments, la colorimétrie est proposée depuis quelques années. Elle permet plus de rigueur. En tous cas, elle permet d'aligner des chiffres dont les variations peuvent être étudiées dans le temps. Le présent travail a permis de tester, de "calibrer" la méthodologie colorimétrique dans le domaine de l'érythème cutané. D'une part, l'effet vasodilatateur (érythémateux) de l'histamine, de l'autre, le blanchiment induit par l'application de topiques corticoïdes et phytopharmaceutiques ont été mesurés et discutés. [less ▲]

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See detailAspects immunologiques et hématologiques de l'infection par le virus HIV
Delhougne, B.; Fillet, Georges ULg

in Revue Médicale de Liège (1993), 48(2), 72-80

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See detailAn Unusual Case of Cor Triatriatum: Clinical Presentation and the Haemodynamics of a Rare Anomaly
Radermecker, M. A.; Grenade, Thierry ULg; Jalali, H. et al

in Cardiovascular Surgery (1993), 1(1), 83-5

The case of a 24-year-old woman with cor triatriatum sinister and a persistent left superior vena cava connected to the junction of the left upper pulmonary vein and left atrium is reported. A diagnosis ... [more ▼]

The case of a 24-year-old woman with cor triatriatum sinister and a persistent left superior vena cava connected to the junction of the left upper pulmonary vein and left atrium is reported. A diagnosis of partial anomalous pulmonary venous return had been made and the patient underwent surgery. Inspection of the left atrium revealed a complex form of left triatrial heart. The general haemodynamics of the malformation are discussed, with particular emphasis on the features accounting for variation in the clinical presentation. This rare anomaly often remains undiagnosed before surgery and should be considered whenever obstruction of pulmonary venous flow above the mitral valve is not explained by pulmonary vein stenosis, mitral or mitral valve-linked abnormalities, atrial tumours or anomalous pulmonary venous drainage with high resistance to flow. [less ▲]

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See detailStrychnopentamine, a Potential Anticancer Agent
Quetin-Leclercq, J.; Bouzahzah, B.; Pons, A. et al

in Planta Medica (1993), 59(1), 59-62

We analysed the effects of strychnopentamine, an alkaloid isolated from Strychnos usambarensis, on an Ehrlich ascites tumor growing in the mouse after inoculation. Four subcutaneous injections of 1.5 mg ... [more ▼]

We analysed the effects of strychnopentamine, an alkaloid isolated from Strychnos usambarensis, on an Ehrlich ascites tumor growing in the mouse after inoculation. Four subcutaneous injections of 1.5 mg strychnopentamine (1 per day) induce a significant decrease of the number of tumor cells and a significant increase of the survival of the treated mice. Observed side effects are partial haemolysis and some liver damage. [less ▲]

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See detailMultiple System Organ Failure after open-heart surgery in infants and children
Seghaye, Marie-Christine ULg; Engelhardt, W.; Grabitz, R. G. et al

in Thoracic and Cardiovascular Surgeon (1993), 41(1), 49-53

Between January 1985 and March 1989 we retrospectively observed Multiple System Organ Failure (MSOF) in 16 of 460 children (3.5%) who underwent cardiac surgery with cardiopulmonary bypass for congenital ... [more ▼]

Between January 1985 and March 1989 we retrospectively observed Multiple System Organ Failure (MSOF) in 16 of 460 children (3.5%) who underwent cardiac surgery with cardiopulmonary bypass for congenital heart disease. MSOF was arbitrarily defined as a clinical entity with failure of two or more vital organ systems associated with high fever, thrombocytopenia, and cardiocirculatory insufficiency and occurring within the first postoperative week. In 13 children the first clinical manifestations of MSOF were evident on the first postoperative day and in the other 3 on the second or third postoperative day. All children showed acute renal failure, acute hepatic failure, high fever, and thrombocytopenia. Most of them showed respiratory insufficiency and neurological involvement. Seven of the 16 children died. Four of the 9 surviving patients had neurological sequelae still present 6 months after the operation, and the others recovered completely. [less ▲]

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See detailBrachymorphism-Onychodysplasia-Dysphalangism Syndrome
Verloes, Alain ULg; Bonneau, D.; Guidi, O. et al

in Journal of Medical Genetics (1993), 30(2), 158-61

Three unrelated children are reported with intrauterine proportionate growth retardation and facial dysmorphism (broad nose, flat malar area, large mouth, pointed chin), microcephaly, hypo/aplasia of the ... [more ▼]

Three unrelated children are reported with intrauterine proportionate growth retardation and facial dysmorphism (broad nose, flat malar area, large mouth, pointed chin), microcephaly, hypo/aplasia of the terminal fifth digits, and (sub)normal intelligence. Radiological findings include hypo/aplasia or fusion of the distal phalanges of the fifth finger and toe, brachymesophalangism V, and nail dysplasia or aplasia. One child had cystic adenomatoid disease of the lung. The pattern of anomalies presented by these children closely resembles a syndrome incompletely delineated in 1971 by Senior in six children, which has often been considered to be a mild form of Coffin-Siris syndrome. We suggest that this is an independent entity (BOD syndrome). The aetiology is still unknown. Differential diagnosis and nosological difficulties are discussed. [less ▲]

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See detailLas cosas escritas en la Nueva España
Vanden Berghe, Kristine ULg

in L'ordinaire. Mexique Amérique Centrale (1993), 143

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See detailCloning, Sequence and Structural Features of a Lipase from the Antarctic Facultative Psychrophile Psychrobacter Immobilis B10
Arpigny, J. L.; Feller, Georges ULg; Gerday, Charles ULg

in Biochimica et Biophysica Acta (1993), 1171(3), 331-3

A lipase gene (lip1) from the facultative psychrophilic strain Psychrobacter immobilis B10 has been cloned and sequenced. The deduced preprotein sequence is composed of 317 amino acids with a predicted M ... [more ▼]

A lipase gene (lip1) from the facultative psychrophilic strain Psychrobacter immobilis B10 has been cloned and sequenced. The deduced preprotein sequence is composed of 317 amino acids with a predicted M(r) of 35,288. A primary structure alignment of lipases including lip1 shows conserved elements for which a structural role is proposed in the light of recent crystallographic studies. The analysis of the psychrophilic enzyme sequence suggests characteristics in relation with the adaptation to cold. [less ▲]

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See detailA first look at the ASSI ultraviolet results
Chakrabarti, S.; Gladstone, G. R.; Tobiska, W. K. et al

in Advances in Space Research (1993), 13

The Airglow and Solar Spectrometer Instrument (ASSI) on the San Marco D satellite has obtained near-simultaneous measurements of solar irradiances and airglow emissions in the 200-7000 A spectral region ... [more ▼]

The Airglow and Solar Spectrometer Instrument (ASSI) on the San Marco D satellite has obtained near-simultaneous measurements of solar irradiances and airglow emissions in the 200-7000 A spectral region. The satellite was placed in an equatorial, elliptical orbit on 25 March 1988, which permitted observations of airglow emissions in the 280-600-km altitude range at various local times. The instrument complement on the satellite provides an opportunity both for self-consistent examination of the excitation mechanisms of various airglow features and for constraining model parameters. An overview of the data obtained by ASSI is presented along with preliminary modeling results of the UV airglow. [less ▲]

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See detailAutres médiateurs de l'inflammation et du sepsis
Lamy, Maurice ULg; Deby, Ginette ULg; Damas, Pierre ULg

in Revue du Praticien (La) (1993), 43(1), 19-25

During sepsis, the systemic inflammatory response is characterized by the release of numerous mediators supporting and dispersing inflammation. In Gram negative sepsis, the endotoxins play a starting role ... [more ▼]

During sepsis, the systemic inflammatory response is characterized by the release of numerous mediators supporting and dispersing inflammation. In Gram negative sepsis, the endotoxins play a starting role, while in other sepsis, the triggering mediators or mechanisms are unknown but lead to a similar inflammatory reaction. Coagulation and complement cascades are activated, with the release of chemoattractive substances, mediators and proteases and the activation of phagocytic cells. Macrophages/monocytes and polymorphonuclear leucocytes produce then active oxygen species and cytokines; they degranulate (releasing active enzymes such as myeloperoxidase), they express an increasing number of membrane receptors able to interact with endothelial cells and release a supplementary lot of inflammatory mediators (prostanoids, platelet activating factor, leukotrienes ... ). Platelets, also activated, produce the same mediators (TXA2, PAF ...) or specific ones such as serotonine, platelet factor 4, growth factors. Last, but not least, the endothelial cells are stimulated, directly (by endotoxins) or undirectly (by cytokines, C5a, PAF ...). These cells play then a main role by their own phagocytic activity, by alteration of their antithrombotic and fibrinolytic potential, by their secretion of inflammatory mediators and by an increased expression of receptors of adhesivity for the activated phagocytes or platelets, what leads to endothelium injury with membrane permeability alterations. These cascades of activation, these extensions of the inflammatory reaction by the mediators and by the phagocytes and platelets can explain the frequency of multiple organ failure during sepsis as well as the difficulty of an adequate pharmacological therapy. [less ▲]

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See detailResults of metagnostic (system-oriented) and diagnostic (process-oriented) models
Beckers, Jean-Marie ULg; Haus, J.; Nihoul, Jacques ULg et al

in Progress in Belgian Oceanographic Research (1993)

After a review of the Mediterranean system, and the justification of the scientific interest, we examine the type of model (scope, purview and resolution) used for the description and simulation of the ... [more ▼]

After a review of the Mediterranean system, and the justification of the scientific interest, we examine the type of model (scope, purview and resolution) used for the description and simulation of the Mediterranean circulation from a system-oriented view and a process-oriented view. These two aspects of mathematical simulations are then illustrated by two examples: a) The simulation of the month to month variability of the general circulation in the Western Mediterranean Sea shows the main physical features, but the choice of initial conditions is crucial for a realistic simulation, and an inverse model is proven to be absolutely necessary for a valuable prognostic model. b) Secondly, a high resolution simulation of the Algerian Current instability is performed. It is well known that the Atlantic water flows along the Algerian coast as a light water intrusion. This current is unstable, and mesoscale activities generate cyclones and anticyclones, but only the latter grow enough to get separated from the mean flow. Numerical simulations, in an idealized case, and reality show strong instabilities that are analyzed by energy budgets. It is suggested that the instabilities are primarily baroclinic, which is consistent with initial vertical movements at the front. [less ▲]

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See detailPulmonary Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1993), 54(1), 168-73

The purpose of this study was to investigate the mechanism by which 5-hydroxytryptamine (5-HT) modifies respiratory function, specifically, hyperventilation, diffuse bronchoconstriction, and pulmonary ... [more ▼]

The purpose of this study was to investigate the mechanism by which 5-hydroxytryptamine (5-HT) modifies respiratory function, specifically, hyperventilation, diffuse bronchoconstriction, and pulmonary arterial hypertension in cattle. We determined whether the IV response to 5-HT in calves was attributable to stimulation of 5-HT2 receptors. Six healthy unsedated young bull calves of the Friesian (n = 4) and of the Belgian White and Blue (n = 2) breeds were used. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg of body weight) was administered IM 30 minutes before the cattle were given a 5-minute IV 5-HT infusion. Pulmonary function values were registered before, during, and after the 5-HT challenge infusion. Minute volume increased significantly, because of an increase in respiratory rate. Conversely, lung dynamic compliance, total pulmonary resistance, and pulmonary arterial pressure were not changed. We concluded that in cattle, 5-HT-induced ventilatory response is not mediated through activation of 5-HT2 receptors. However, the 5-HT2 receptors are involved in 5-HT-induced broncho- and pulmonary vasoconstriction. [less ▲]

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See detailIdentification of Different Target Glycoproteins for Bovine Herpes Virus Type 1-Specific Cytotoxic T Lymphocytes Depending on the Method of in Vitro Stimulation
Denis, M.; Slaoui, M.; Keil, G. et al

in Immunology (1993), 78(1), 7-13

Vaccinia virus recombinants expressing the three major bovine herpes virus-1 (BHV-1) glycoproteins gI, gIII and gIV were used to identify the major target antigens for BHV-1-specific CTL isolated from ... [more ▼]

Vaccinia virus recombinants expressing the three major bovine herpes virus-1 (BHV-1) glycoproteins gI, gIII and gIV were used to identify the major target antigens for BHV-1-specific CTL isolated from immune cattle. Peripheral blood mononuclear cells (PBMC) expanded in vitro in the presence of interleukin-2 (IL-2) and lysed both gIII- and gIV-infected target cells. Secondary in vitro stimulation of PBMC was also performed in the presence of either fixed BHV-1-infected autologous fibroblasts or ultraviolet (UV)-inactivated virus. Both methods of antigen presentation allowed the proliferation of BHV-1-specific CTL but the target glycoprotein for these CTL differed depending on the method of stimulation. Vaccinia-gIV-infected targets were lysed predominantly when PBMC were stimulated by fixed infected fibroblasts, whilst PBMC stimulated by UV-inactivated virus lysed mostly vaccinia-gIII-infected targets. This observation could be explained by a different processing pathway of BHV-1 antigens in each cell type involved. [less ▲]

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See detailComparison between Alprazolam and Hydroxyzine for Oral Premedication
Franssen, Colette ULg; Hans, Pol ULg; Brichant, Jean-François ULg et al

in Canadian Journal of Anaesthesia = Journal Canadien d'Anesthésie (1993), 40(1), 13-7

The safety and efficacy of alprazolam and hydroxyzine administered orally as surgical premedicants were compared in a double-blind controlled study. Sixty-five patients were given either alprazolam 1 mg ... [more ▼]

The safety and efficacy of alprazolam and hydroxyzine administered orally as surgical premedicants were compared in a double-blind controlled study. Sixty-five patients were given either alprazolam 1 mg or hydroxyzine 75 mg, one to two hours before surgery. Anxiety was assessed by both the patient and the anaesthetist, the patient using a visual analogue scale, the anaesthetist employing both analogue and ordinal ratings. Sedation was assessed by the anaesthetist only, using the same two methods. Amnesia was appraised with a simple memory test. Safety was assessed by recording adverse effects and measuring haemodynamic variables. Premedication with alprazolam produced a modest reduction in anxiety (28%) (P < 0.01) while hydroxyzine had no detectable effect. The comparison of the sedation level and of the memory test revealed no difference between the two premedicants. Minor side effects were only observed in the hydroxyzine group. Changes in blood pressure were more pronounced in the hydroxyzine group. This study shows that alprazolam and hydroxyzine are safe and efficient oral premedicants. However, alprazolam is preferable to hydroxyzine in terms of anxiolytic and adverse effects. [less ▲]

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See detailPlasma Na-K ATPase inhibitor activity and intracellular ions during hemodialysis
Krzesinski, Jean-Marie ULg; Du, F.; Pequeux, M. L. et al

in International Journal of Artificial Organs (1993), 16(1), 23-30

We have investigated the relationship between plasma Na-K ATPase inhibitor activity (EDLS) and intracellular ions in 37 uremic hemodialysed hypertensive patients, and in 20 normotensive non uremic ... [more ▼]

We have investigated the relationship between plasma Na-K ATPase inhibitor activity (EDLS) and intracellular ions in 37 uremic hemodialysed hypertensive patients, and in 20 normotensive non uremic controls (NC). As compared with the NC population, significantly enhanced values for erythrocyte (RBC) Na, Ca, platelet cytosolic Ca and EDLS were observed in all the uremic patients tested just before a dialysis session, as well as a decrease in RBC Ca ATPase and in the platelet pH. In uremia, significant correlations have been noted between RBC Na and platelet Ca (r = 0.6) or systolic BP (r = 0.45); between platelet Ca and systolic blood pressure (r = 0.8) or diastolic BP (r = 0.5) and between EDLS and RBC Na, Ca or platelet Ca (r = 0.5). Anti-hypertensive treatment has no influence on these parameters. During dialysis, a significant decrease has been noted in RBC Na, Ca, platelet Ca, SBP (only in untreated patients) and EDLS and an increase in RBC Ca ATPase and platelet pH. These modifications are significantly correlated with the weight change. [less ▲]

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See detailVivre avec un nouveau coeur
Triffaux, Jean-Marc ULg

in Revue Médicale de Liège (1993), 48(1), 19-25

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See detailPaget's Disease of Bone Treated with a Five Day Course of Oral Tiludronate
Reginster, Jean-Yves ULg; Lecart, Marie-Paule ULg; Deroisy, Rita ULg et al

in Annals of the Rheumatic Diseases (1993), 52(1), 54-7

Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have ... [more ▼]

Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have only been seen at doses much higher than those required to decrease osteoclastic activity, it could be given at high doses over a short period of time. Eighteen patients with Paget's disease of bone were randomly allocated to three therapeutic groups receiving respectively 600, 800, and 1200 mg/day tiludronate for five days. Serum alkaline phosphatase activity and the urinary hydroxyproline/creatinine ratio were quickly and drastically reduced in all three groups. A significant reduction of serum alkaline phosphatases and the hydroxyproline/creatinine ratio was still present six months after the five day therapeutic course, reflecting a sustained activity of tiludronate even after stopping treatment. Dose dependent short and long term reductions of bone turnover rate were observed. Biochemical assessment of haematological, renal, or hepatic tolerance did not show any toxicity of tiludronate. Fifty per cent of patients treated by a dose of 1200 mg/day reported gastrointestinal disturbances, however, making this dosage unsuitable for clinical practice. [less ▲]

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See detailA novel mutation in the proteolipid protein gene leading to Pelizaeus-Merzbacher disease.
Otterbach, B.; Stoffel, W.; RAMAEKERS, Vincent ULg

in Biological chemistry Hoppe-Seyler (1993), 374(1), 75-83

Point mutations of the gene of human proteolipid protein (PLP) have been recognized as the molecular basis of one form of leukodystrophy, the X-chromosome-linked Pelizaeus-Merzbacher disease (PMD). We ... [more ▼]

Point mutations of the gene of human proteolipid protein (PLP) have been recognized as the molecular basis of one form of leukodystrophy, the X-chromosome-linked Pelizaeus-Merzbacher disease (PMD). We report the molecular analysis of four PMD patients in three unrelated families and describe a point mutation (G-->A transition) in exon V which leads to the substitution of Gly216 by a serine residue in a highly conserved extracytosolic domain and a Mae I RFLP. Molecular modelling with energy minimization indicates that this seemingly minor alteration of the amino-acid sequence induces a considerable conformational change and tight packing of the polypeptide chain apparently not compatible with the regular PLP function in oligodendrocytes. This mutation has been detected and characterized by PCR amplification of genomic DNA using intron and exon primers and the complete sequence analysis of the seven exons and a 300 bp promoter region of the PLP gene of two affected brothers. The sequence analysis of a PCR fragment representing exon V amplified from genomic DNA of different kindreds of the pedigree revealed the mother as the only carrier indicating that the mutation has occurred de novo in the mother's germline. PLP gene (including the 8.8 kb intron I) rearrangements have been excluded by Southern blot hybridization and overlapping PCR amplification of genomic DNA. [less ▲]

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See detailPhotophysical investigation of Rose Bengal in aqueous sodium taurocholate solutions
Seret, Alain ULg; Van de Vorst, Albert

in Journal of Photochemistry and Photobiology B : Biology (1993), 17(1), 47-56

The photophysics of rose bengal has been studied in aqueous sodium taurocholate solutions with or without 0.6 mol NaCl dm−3. The ground and first excited singlet states solubilize only in the aggregates ... [more ▼]

The photophysics of rose bengal has been studied in aqueous sodium taurocholate solutions with or without 0.6 mol NaCl dm−3. The ground and first excited singlet states solubilize only in the aggregates formed by sodium taurocholate, whereas the first triplet state solubilizes both in the bulk phase and in the aggregates. A lower limit of the corresponding entry and exit rate constants ke and ks, respectively has been estimated: ke ≥ 5 X 106 dm3 mol−1 s−1 (2x107 dm3 mol−1 s−1 with 0.6 mol NaCl dm−3) and ks ≥ 105 s−1. The triplet state as well as the semioxidized radical react with the taurocholate anion. The former reaction leads to the formation of semireduced dye. The latter is responsible for the detection of only semioxidized radicals which move freely in the aqueous phase. The results are compared with those obtained previously in aqueous sodium dodecyl sulphate solutions and the possible biological implication is discussed. [less ▲]

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See detailMisdiagnosed Malignancy in Transplanted Organs
Detry, Olivier ULg; Detroz, Bernard ULg; D'Silva, M. et al

in Transplant International (1993), 6(1), 50-4

The case reports of three patients who received cancer-bearing organs at this institution are presented. A fourth recipient, who was to be transplanted with a cancerous kidney, was spared this disastrous ... [more ▼]

The case reports of three patients who received cancer-bearing organs at this institution are presented. A fourth recipient, who was to be transplanted with a cancerous kidney, was spared this disastrous complication. The relevant data regarding the donors is also alluded to, with special reference to the type and site of the primary malignancy. Following these case reports, the implications of these issues, their possible prevention, and further management are discussed. [less ▲]

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See detailHeightened selectivity in aromatic nitrations and chlorinations by the use of solid supports and catalysts
Delaude, Lionel ULg; Laszlo, Pierre ULg; Smith, Keith

in Accounts of Chemical Research (1993), 26(12), 607-613

The heightened selectivity in aromatic nitrations and chlorinations using solid supports and catalysts is reviewed with 67 references.

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See detailCHARACTERIZATION OF A HIGHLY PHOTOACTIVE MOLECULAR SEMICONDUCTOR - OXOTITANIUM PHTHALOCYANINE
Ghosez, Philippe ULg; COTE, R.; GASTONGUAY, L. et al

in Chemistry of Materials (1993), 5(10), 1581-1590

Oxotitanium phthalocyanine (OTiPc) thin films have been sublimed at various thicknesses on SnO2 and glass substrates. The morphology, crystallinity, and photoelectrochemical activity of the films have ... [more ▼]

Oxotitanium phthalocyanine (OTiPc) thin films have been sublimed at various thicknesses on SnO2 and glass substrates. The morphology, crystallinity, and photoelectrochemical activity of the films have been studied. It was found that the physical and photoelectrochemical properties of the films are greatly influenced by the temperature reached by the substrate during the sublimation. Below 80-degrees-C, amorphous films are obtained while the films are partially crystalline when the substrate is allowed to reach about 140-degrees-C. Amorphous films are made of tightly packed aggregates of circular section while partially crystalline films consists of platelets. All films are porous and permeable to the I3-/I- redox system. The dominant polymorph in partially crystalline films is not the same for all film thicknesses. It is phase IV OTiPc (as deduced by electron diffraction) for films thinner than about 2000 angstrom. On the other hand, for films thicker than about 8000 angstrom, phase I OTiPc becomes the dominant polymorph (as deduced by X-ray diffraction). It is replaced by phase II for 20 000-angstrom-thick films of OTiPc. Partially crystalline films are the only ones to absorb in the near-infrared (NIR) region. This typical absorption is going along with an improvement of the photoactivity of the films. In partially crystalline films, energy is transferred from the amorphous to the crystalline regions where most of the charges are generated. Quantum yields for electron collection per incident photon may reach over 25% in short circuit conditions, at 850 nm, the Q-band absorption maximum for 8000-angstrom-thick films. Those films are phase I OTiPc. Under 35 MW CM-2 polychromatic illumination, the same films are characterized by short circuit photocurrents of 1.5 mA cm-2. A NIR absorbance is an important factor required to obtain a high photoactivity, but it is not the only one. Interaction of OTiPc with oxygen at the purification level of the crude material is very important as well. [less ▲]

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See detailOn the Use of Distance in the Taxonomic Study of Critical Plant Groups-Case Studies of Western European Orchidaceae
Tyteca, D.; Dufrêne, Marc ULg

in Annals of Botany (1993), 71(3), 257-277

Four distance coefficients are compared on four data sets composed of samples coming from western European populations of the genera Dactylorhiza, Orchis and Epipactis (Orchidaceae). The performance of ... [more ▼]

Four distance coefficients are compared on four data sets composed of samples coming from western European populations of the genera Dactylorhiza, Orchis and Epipactis (Orchidaceae). The performance of the distance coefficients is evaluated through: (a) the quality of clusters obtained by five classical methods (as compared to a priori classification), (b) the Mantel statistic with respect to an a priori distance matrix resulting from previous knowledge, (c) the result obtained with the k-means method, and (d) principal coordinate diagrams. It appears that: (a) the Mahalanobis distance based on the pooled dispersion matrix performs best on the whole; (b) a distance based on the recently developed Common Principal Component model, used with a log transformation, also provides useful information and performs best on the largest data set; (c) the Gölz and Reinhard taxonomic distance, widely used among orchidologists, is attractive for its simplicity, yet good performance and the valuable information it provides, despite its theoretical shortcomings. A brief taxonomic discussion is made on the results obtained for the Dactylorhiza samples, especially about samples whose identification was in doubt. [less ▲]

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See detailLes chimpanzés : un modèle animal de la relation clientélaire
Servais, Véronique ULg

in Terrain (1993), 21(octobre), 67-80

The paper is about the dominance and coalition relationship among male chimpanzees. It focuses on the dependance relationship between the members of the coalition and distinguishes stable and unstable ... [more ▼]

The paper is about the dominance and coalition relationship among male chimpanzees. It focuses on the dependance relationship between the members of the coalition and distinguishes stable and unstable coalitions. A coalition is unstable if the support of the dominated individual is conditional and stable if it is not (i.e. among two brothers). In an unstable coalition the dominated indivuual can afford some priviledge, the dominant is very dependent on the subordinate and the relationship with the dominant is tense. Analogies with human power relationships are suggested. [less ▲]

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See detailContribution à l'étude des effets de l'exposition à des champs magnétiques 50 Hz sur certains paramètres neuropsychologiques et neuroendocriniens
Crasson, Marion ULg; Timsit-Berthier, Martine; Legros, Jean-Jacques ULg

in Psychologie Médicale (1993), 25(13), 1341-1346

Depuis une trentaine d'années, l'exposition des populations industrialisées aux champs électromagnétiques 50/60 Hz n'a cessé de susciter des polémiques concernant ses éventuels effets nocifs. Cette étude ... [more ▼]

Depuis une trentaine d'années, l'exposition des populations industrialisées aux champs électromagnétiques 50/60 Hz n'a cessé de susciter des polémiques concernant ses éventuels effets nocifs. Cette étude préliminaire a été réalisée avec un appareillage original, qui génère des champs magnétiques comparables à ceux rencontrés dans la vie quotidienne. Deux groupes de 10 volontaires en bonne santé ont participé à cette recherche, le premier réellement exposé à un champ d'induction magnétique de 142 microtesla, 50 Hz, pendant une demi-heure, le deuxième exposé de manière simulée. Nos résultats montrent que le champ magnétique n'engendre aucun effet perceptible mais qu'il provoque une légère modification de certains paramètres psychologiques (humeur, attention visuelle). [less ▲]

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See detailOptimal Foraging By Hoverflies (Diptera, Syrphidae) And Ladybirds (Coleoptera, Coccinellidae) - Mechanisms
Hemptinne, Jl.; Dixon, Afg.; Doucet, Jean-Louis ULg et al

in European Journal of Entomology (1993), 90(4), 451-455

Coccinellids and syrphids that feed on aphids and coccids face the same problem: an unstable food supply. Their eggs and larvae face cannibalism and/or starvation if the aphid colony they attack declines ... [more ▼]

Coccinellids and syrphids that feed on aphids and coccids face the same problem: an unstable food supply. Their eggs and larvae face cannibalism and/or starvation if the aphid colony they attack declines in abundance before they mature. Optimal foraging theory predicts that such predators should lay a few eggs early in the development of an aphid colony. Studies on two species of coccinellid and one species of syrphid revealed that they do respond to the quality as well as the abundance of their prey. By refraining from laying eggs in aphid colonies already exploited by predators and those that are shortly to decline in abundance when the aphids disperse, these predators are able to forage in a way that is consistent with the predictions of optimal foraging theory. [less ▲]

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See detailON THE FORMATION OF PHOTOSYSTEM-II CHLOROPHYLL PROTEINS AFTER A SHORT LIGHT FLASH IN ETIOLATED BARLEY LEAVES, AS MONITORED BY INVIVO FLUORESCENCE SPECTROSCOPY
Franck, Fabrice ULg

in Journal of Photochemistry and Photobiology B : Biology (1993), 18(1), 35-40

The biogenesis of photosystem II (PSII) was investigated using 77 K fluorescence spectroscopy in etiolated barley leaves subjected to a millisecond flash which reduced all protochlorophyllide (Pchlide ... [more ▼]

The biogenesis of photosystem II (PSII) was investigated using 77 K fluorescence spectroscopy in etiolated barley leaves subjected to a millisecond flash which reduced all protochlorophyllide (Pchlide) into chlorophyllide (Chlide). In darkness after the flash, a slow chlorophyll (Chl) band shift from 682 to 684 nm was associated with the development of PSII variable fluorescence. Two Chl fluorescence bands at 678 and 687 nm were formed during the shift, the 687 nm band corresponding to the spectrum of the PSII variable fluorescence. The development of PSII fluorescence was inhibited by chloramphenicol and enhanced by cyclobeximide, suggesting a competition between plastid- and nucleus-encoded proteins for Chl binding. [less ▲]

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See detailAérosolthérapie chez le cheval : 3. Etude clinique
Lekeux, Pierre ULg; Genicot, Bruno; Votion, Dominique ULg et al

in Pratique Vétérinaire Equine (1993), 25(4), 245-248

This review analyzes the advantages, disadvantages, limites and clinical applications of aerosoltherapy in equine medicine

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See detailCloning and overexpression of the triosephosphate isomerase genes from psychrophilic and thermophilic bacteria. Structural comparison of the predicted protein sequences
Rentier-Delrue, Françoise ULg; Mande, Shekhar C; Moyens, Sylvianne et al

in Journal of Molecular Biology (1993), 229(1), 85-93

We focused on the temperature adaptation of triosephosphate isomerase (TIM; E.C. 5.3.1.1.) by comparing the structure of TIMs isolated from bacterial organisms living in either cold or hot environments ... [more ▼]

We focused on the temperature adaptation of triosephosphate isomerase (TIM; E.C. 5.3.1.1.) by comparing the structure of TIMs isolated from bacterial organisms living in either cold or hot environments. The TIM gene from psychrophilic bacteria Moraxella sp. TA137 was cloned and its nucleotide sequence determined. Its deduced amino acid sequence revealed 34% identity with the thermophilic bacteria Bacillus stearothermophilus TIM. Expression vectors were constructed and recombinant Moraxella TA137 and Bacillus stearothermophilus TIMs were overproduced and purified to homogeneity. Recombinant TIM inactivation constants (Ki), measured at various temperatures, compared to those of the mesophilic Escherichia coli recombinant TIM clearly show that Moraxella TA137 and B. stearothermophilus TIMs have respectively psychrophilic and thermophilic characteristics. To try to elucidate the structure-thermolability and structure-thermostability relationship, factors affecting the overall stability of these two TIMs were examined, based on the alignment with the mesophilic chicken TIM, the three-dimensional structure of which is already known. From this comparison, it appears that the adaptability of TIM to high temperature is favored by better stabilizing residues for the helix dipole as well as better helix-forming residues whereas the adaptability of TIM to low temperature seems to reside in the nature of helix-capping residues. [less ▲]

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See detailReaction Dynamics of the Dichlorocarbene Anion Using tandem Mass Spectrometry.
Leyh, Bernard ULg; Mélon, Pierre

in Organic Mass Spectrometry (1993), 28

The dissociation dynamics of CCl2- anions were studied under various internal energy conditions. This study involved the measurement of daughter-ion spectra and branching ratios and of the amount of ... [more ▼]

The dissociation dynamics of CCl2- anions were studied under various internal energy conditions. This study involved the measurement of daughter-ion spectra and branching ratios and of the amount of kinetic energy released (KER) on the fragments. The competition between C and Cl loss for CCl2- ions created by many of the following sequence of processes: CCl4->CCl2+->(G=Xe, Kr C6H6)->CCl2--> fragments (1); CCl4->(CCl2--+[Cl,Cl]+;CCl2-; CCl2- (Ne)-> Fragments (2); CCl4->(CCl2)2+ (C6H6)->CCl2--> fragments (3) was particularly investigated. For process (1), the amount of fragmentating CCl2- ions is 8-10 times larger with Kr than with Xe or C6H6. The KER for Cl loss is smaller than 0.20 eV with the three target gases used. For the loss of C, the KER is much larger (0.7 eV). This KER is, however, equal to 0.21 eV for the collisionally activated C loss in process (2). For this latter process, the C loss vs Cl loss branching ratio decreases with increasing internal energy. The KERs measured for process (3) are vary similar to those obtained for process (1). It is suggested that repulsive or slightly bound excited states which correlate directly to the Cl2-(X2Sigma+)+C asymptote and which are vibronically coupled to the ground state play an important role in these dissociation processes. [less ▲]

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See detailUsing Partial Orders for the Efficient Verification of Deadlock Freedom and Safety Properties
Godefroid, Patrice; Wolper, Pierre ULg

in Formal Methods in System Design (1993), 2(2), 149--164

This article presents an algorithm for detecting deadlocks in concurrent finite-state systems without incurring most of the state explosion due to the modeling of concurrency by interleaving. For systems ... [more ▼]

This article presents an algorithm for detecting deadlocks in concurrent finite-state systems without incurring most of the state explosion due to the modeling of concurrency by interleaving. For systems that have a high level of concurrency, our algorithm can be much more efficient than the classical exploration of the whole state space. Finally, we show that our algorithm can also be used for verifying arbitrary safety properties. [less ▲]

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See detailCHARACTERIZATION OF 3 LABDANE DITERPENES FROM AFRAMOMUM-ALBOVIOLACEUM
Marlier, Michel; LEGUELLEC, G.; Lognay, Georges ULg et al

in Planta Medica (1993), 59(5), 455-457

Two labdane diterpenes were isolated from the seeds and the rhizomes of Aframomum alboviolaceum (Ridley) K. Schum (Zingiberaceae) and identified by GC-MS, H-1-, and C-13-NMR as (E)-labda-8(17),12-diene-15 ... [more ▼]

Two labdane diterpenes were isolated from the seeds and the rhizomes of Aframomum alboviolaceum (Ridley) K. Schum (Zingiberaceae) and identified by GC-MS, H-1-, and C-13-NMR as (E)-labda-8(17),12-diene-15,16-dial (1) and (E)-8beta,17-epoxylabd-12-ene-15,16-dial (2). A third minor compound could be the methyl (E)-14xi,15-epoxylabd-8(17), 12-dien-16-oate. The simultaneous occurrence of these three molecules has been mentioned only in one other species of the same genus, Aframomum daniellii (1). [less ▲]

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See detailPharmacological treatment of the obese diabetic patient.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabète & Métabolisme (1993), 19(6), 547-59

Obesity is a well-known risk factor for non-insulin-dependent (or Type 2) diabetes mellitus. Consequently, reduction of weight excess comes to the front line in the prevention and management of NIDDM. It ... [more ▼]

Obesity is a well-known risk factor for non-insulin-dependent (or Type 2) diabetes mellitus. Consequently, reduction of weight excess comes to the front line in the prevention and management of NIDDM. It is only when diet and physical exercise fail that drug treatment should be considered. Pharmacological treatment of obesity should favour drugs which not only promote weight loss, by reducing caloric intake and/or increasing thermogenesis and energy expenditure, but also, and especially, improve insulin sensitivity. Serotoninergic anorectic compounds (dexfenfluramine, fluoxetine) appear to possess, to some extent, all these properties. Metformin significantly reduces insulin resistance and improves glycaemic control without inducing weight gain, and even favouring some weight loss. This biguanide is now considered as the first line drug for the obese diabetic patient. Alpha-glucosidase inhibitors may help to reduce post-prandial glucose excursions but do not promote weight loss per se. Sulfonylureas can be prescribed to an obese patient when hyperglycaemia persists despite diet and the above-mentioned oral agents, but their use should be associated with reinforcement of dietary advices in order to prevent further weight increase; it is also the case for insulin therapy. Finally, drugs specifically stimulating thermogenesis and energy expenditure, new agents sensitizing tissues to the action of insulin and various compounds interfering with lipid metabolism are currently under extensive investigation with promising preliminary results in the obese diabetic patient. In conclusion, obesity remains a major problem in the management of Type 2 diabetes mellitus and this justifies the search for new, safe and effective, pharmacological approaches. [less ▲]

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See detailL'immersion : une autre façon d'apprendre une langue étrangère
Blondin, Christiane ULg

in Recherche en Education. Théorie & Pratique (1993), 14

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See detailLate Famennian miospore assemblages from the Bergisch Gladbach - Paffrath Syncline, Rhenish Slate Mountains, Germany
Hartkopf-Fröder, C; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1993), 116(2), 333-357

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See detailSequence of a gene encoding a (poly ManA) alginate lyase active on Pseudomonas aeruginosa alginate
Malissard, Martine; Duez, Colette ULg; Guinand, Micheline et al

in FEMS Microbiology Letters (1993), 110(1), 101-106

The recombinant plasmid pAL-A3 bears a (poly ManA) alginate lyase-encoding gene that originates from the marine bacterium ATCC 433367 (Brown et al., Appl. Environ. Microbiol. (1991) 57, 1870-1872). The ... [more ▼]

The recombinant plasmid pAL-A3 bears a (poly ManA) alginate lyase-encoding gene that originates from the marine bacterium ATCC 433367 (Brown et al., Appl. Environ. Microbiol. (1991) 57, 1870-1872). The alginate lyase produced by Escherichia coli TC4 harbouring pAL-A3 was purified to protein homogeneity and the corresponding gene sequenced, giving access to the first known primary structure of an alginate lyase. The 265-amino acid residue alginate lyase showed lytic activity on a Pseudomonas aeruginosa alginate isolated from a cystic fibrosis patient. Unexpectedly, the alginate lyase thus characterized differed from that isolated from the culture medium of the bacterium ATCC 433367 (Romeo and Preston, Biochemistry (1986) 25, 8385-8391). [less ▲]

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See detailDynamics of mitotic activity and expression of viral proteins gp51 and p24 of Bovine Leukemia Virus producing cells.
Roussev, Roussi; Polianova, M.; Portetelle, Daniel ULg et al

in Folia Biologica (1993), 39

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See detailHemodynamic changes during laparoscopic cholecystectomy.
Joris, Jean ULg; Noirot, Didier P; Legrand, Marc ULg et al

in Anesthesia and Analgesia (1993), 76(5), 1067-71

Hemodynamics during laparoscopic cholecystectomy under general anesthesia (isoflurane in N2O/O2 (50%)) were investigated in 15 nonobese ASA Class I patients by using invasive hemodynamic monitoring ... [more ▼]

Hemodynamics during laparoscopic cholecystectomy under general anesthesia (isoflurane in N2O/O2 (50%)) were investigated in 15 nonobese ASA Class I patients by using invasive hemodynamic monitoring including a flow-directed pulmonary artery catheter. During surgery, intraabdominal pressure was maintained automatically at 14 mm Hg by a CO2 insufflator, and minute ventilation was controlled and adjusted to avoid hypercapnia. Hemodynamics were measured before anesthesia, after the induction of anesthesia, after tilting into 10 degrees head-up position, 5 min, 15 min, and 30 min after peritoneal insufflation, and 30 min after exsufflation. Induction of anesthesia decreased significantly mean arterial pressure and cardiac index (CI). Tilting the patient to the head-up position reduced cardiac preload and caused further reduction of CI. Peritoneal insufflation resulted in a significant increase (+/- 35%) of mean arterial pressure, a significant reduction (+/- 20%) of CI, and a significant increase of systemic (+/- 65%) and pulmonary (+/- 90%) vascular resistances. The combined effect of anesthesia, head-up tilt, and peritoneal insufflation produced a 50% decrease in CI. Administration of increasing concentrations of isoflurane, via its vasodilatory activity, may have partially blunted these hemodynamic changes. These results demonstrate that laparoscopy for cholecystectomy in head-up position results in significant hemodynamic changes in healthy patients, particularly at the induction of pneumoperitoneum. [less ▲]

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See detailL'évaluation des effets de LOGO : un bilan vingt ans après ...
Denis, Brigitte ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1993)

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See detailAnalgésie postopératoire par analgésie péridurale autocontrôlée
Joris, Jean ULg

in Douleur et analgésie (1993), 4

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in New Steel Construction (1993), 1(N°6), 30-33

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See detailEchec des élèves, échec de l'école ?
Crahay, Marcel ULg

in Recherche en Education. Théorie & Pratique (1993), 11-12

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See detailLa myocardiopathie hypertrophique obstructive: options therapeutiques chirurgicales.
Radermecker, Marc ULg; SAKALIHASAN, Natzi ULg; Partoune, B. et al

in Revue Médicale de Liège (1993), 48(12), 659-65

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See detailEffect of a Booster Vaccination against Influenza and Equine Herpes Virus on Cardio-Respiratory Adjustments to Strenuous Exercise and Training in Thoroughbred Horses
Art, Tatiana ULg; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40(7), 481-491

This study was conducted in order to assess whether exercise- and training-induced cardio-respiratory adjustments are modified during the 10-day period which follows a booster vaccination with an oily ... [more ▼]

This study was conducted in order to assess whether exercise- and training-induced cardio-respiratory adjustments are modified during the 10-day period which follows a booster vaccination with an oily adjuvanted inactivated vaccine against influenza and equine herpesvirus-1 (Equiffa). Nine healthy vaccinated thoroughbred horses were used. Six were revaccinated and three were kept as control. All the horses completed a standardised exercise test (SET) that was repeated 4 times, i.e. 10 (SET1) and 2 (SET2) days before revaccination, and 2 (SET3) and 10 (SET4) days after revaccination. During the whole experimental period the horses were trained 6 days per week according to an interval training schedule. Respiratory airflow, tidal volume, respiratory rate and expired minute volume (VE) were measured using a face mask and 2 ultra-sonic pneumotachographs. The oxygen uptake (VO2) and carbon dioxide production (VCO2) were obtained on a breath-by-breath basis, using a mass spectrometer. Heart rate (HR) was continuously measured with a polar horse tester. Venous blood was sampled before and after the test and analysed for biochemical determinations. Blood was also sampled before and 21 days after the booster vaccination for circulating antibody titration. The peak VO2, VCO2, ventilatory equivalent (VE/VO2) and oxygen pulse (VO2/HR) were significantly improved by the 3-week training period. The other cardio-respiratory parameters as well as most of the blood parameters remained unchanged throughout the 4 SETs. The revaccination did not impair any of the parameters measured before, during, or after the SETs. All revaccinated horses showed a rise in antibodies against influenza virus type A1 and A2 and EVH-1 compared to the control horses. It was concluded that, in our horses, revaccination with an oily adjuvanted inactivated vaccine against influenza and EVH-1 did not impair their cardiorespiratory and metabolic adjustments to strenuous exercise and intense training, and that the seroconversion due to revaccination was unaffected by the intense daily exercise experienced by the animals in the post-vaccination period [less ▲]

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See detailTemporal reasoning and reasoning theories : a case study in anaesthesiology
Sougné, Jacques ULg; Nyssen, Anne-Sophie ULg; De Keyser, Véronique ULg

in Psychologica Belgica (1993), 33(2), 311-328

The purpose of this article is to clarify the theoritical base necessary for the design of a computer-based simulation of temporal reasoning. Simulation allows a better understanding of phenomena that ... [more ▼]

The purpose of this article is to clarify the theoritical base necessary for the design of a computer-based simulation of temporal reasoning. Simulation allows a better understanding of phenomena that appear in working situations and even, understanding and preventing some human errors. In order ot illustrate theoritical concepts, we will provide examples of a situation in which the dynamic character of the evolution, the critical character of the planning and of the synchronization force temporal reasoning. This situation will be that of anaesthesia. [less ▲]

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See detailStructure of the 16 S ribosomal RNA of the thermophilic cyanobacterium Chlorogloeopsis HTF (‘Mastigocladus laminosus HTF’) strain PCC75 18, and phylogenetic analysis
Wilmotte, Annick ULg; Van Der Auwera, Gert; De Wachter, Rupert

in FEBS Letters (1993), 317

The thermophilic cyanobacterial strain, PCC7518, originally identified as ‘Mu~tigocludus hminosus HTF’ does not show branchings or heterocysts. The absence of branchings supports the later assignment to ... [more ▼]

The thermophilic cyanobacterial strain, PCC7518, originally identified as ‘Mu~tigocludus hminosus HTF’ does not show branchings or heterocysts. The absence of branchings supports the later assignment to the genus Chlorogloeopsu. The absence of heterocysts may be the result of a mutation because heterocysts were observed in the original isolate. Alternatively, contamination may have happened. To solve this problem, the 16 S rRNA sequence was determined and used to infer a secondary structure model and build distance trees. The trees showed that strain PCC7518 belongs to the cluster of heterocystous species and has most probably lost the abihty to produce heterocysts by mutation. It is only distantly related to Chlorogloeopsis fritschii PCC67 18. [less ▲]

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See detailDecision tree approaches to voltage security assessment
Van Cutsem, Thierry ULg; Wehenkel, Louis ULg; Pavella, Mania ULg et al

in IEE Proceedings - Generation, Transmission & Distribution (1993), 140

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See detailEpidural anesthesia and intrathoracic blood volume.
Warner, David O; Brichant, Jean-François ULg; Ritman, Erik L et al

in Anesthesia and Analgesia (1993), 77(1), 135-40

To investigate how epidural anesthesia changes intrathoracic gas volume, high epidural anesthesia was administered to five pentobarbital-anesthetized dogs lying supine, and the total intrathoracic volume ... [more ▼]

To investigate how epidural anesthesia changes intrathoracic gas volume, high epidural anesthesia was administered to five pentobarbital-anesthetized dogs lying supine, and the total intrathoracic volume at end-expiration was measured with a high-speed three-dimensional x-ray scanner. The amount of gas in the lungs at end-expiration [the functional residual capacity (FRC)] was measured with a nitrogen washout technique, and the intrathoracic tissue volume, including the intrathoracic blood volume, was calculated as the difference between intrathoracic volume at end-expiration and FRC. High epidural anesthesia with the local anesthetic etidocaine to a T-1 myotomal level significantly (P < 0.05) increased intrathoracic volume at end-expiration [76 +/- 35 mL (M +/- SD)] by significantly increasing both intrathoracic tissue volume (33 +/- 15 mL) and FRC (43 +/- 26 mL). Increases in intrathoracic tissue volume were probably caused by increases in intrathoracic blood volume. We conclude that increases in FRC caused by epidural anesthesia in anesthetized dogs lying supine may be minimized by a concurrent increase in intrathoracic blood volume. These results suggest that measurements of thoracic gas volume alone may be insufficient to describe chest wall responses to epidural anesthesia. [less ▲]

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See detailLa racine grb et l'Amon-grb
Malaise, Michel ULg; Winand, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1993), 68

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See detailMetabolism of Thiamine Triphosphate in Rat Brain: Correlation with Chloride Permeability
Bettendorff, Lucien ULg; Peeters, Maryline; Wins, Pierre et al

in Journal of Neurochemistry (1993), 60(2), 423-434

Our results show that a net synthesis of thiamine triphosphate (TTP) can be demonstrated in vitro using rat brain extracts. The total homogenate was preincubated with thiamine or its diphosphate ... [more ▼]

Our results show that a net synthesis of thiamine triphosphate (TTP) can be demonstrated in vitro using rat brain extracts. The total homogenate was preincubated with thiamine or its diphosphate derivative (TDP), centrifuged, and washed twice. With TDP (1 mM) as substrate, a 10-fold increase in TTP content was observed in this fraction (nuclear fraction, membrane vesicles). A smaller, but significant, increase was observed in the P2 fraction (mitochondrial/synaptosomal fraction). In view of the low TTP content of our fractions, it was carefully assessed that authentic TTP was being formed. Incorporation of radioactivity from [beta-32P]TDP and [gamma-32P]ATP in TTP suggests that these two compounds are its precursors. Furthermore, TTP synthesis was inhibited by ADP and relatively low concentrations of Zn2+. These results suggest that TTP synthesis is catalyzed by an ATP:TDP transphosphorylase rather than by the cytoplasmic adenylate kinase that may be present in the vesicles. After osmotic lysis of the vesicles at alkaline pH, TTP was recovered in protein-bound form. Concomitantly, a soluble thiamine triphosphatase, with alkaline pH optimum, was also released from the vesicles. No net synthesis could be obtained in the cytosolic fraction or in detergent-solubilized systems. Like TTP synthesis, chloride permeability of the vesicles was increased when the homogenate had been incubated with thiamine and particularly with TDP. Our results suggest a regulatory role of TTP on chloride permeability, but the target remains to be characterized. [less ▲]

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See detailMicroencapsulation by Coacervation of Poly(lactide-co-glycolide)-II:Encapsulation of a Dispersed Aqueous Phase
Nihant, Nicole; Stassen, S; Grandfils, Christian ULg et al

in polymer International (1993), 32

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This ... [more ▼]

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drugs phase, and microcapsule solidification. This paper focuses on the physico-chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium. [less ▲]

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See detailAssociation of Aortic Stenosis and Gastrointestinal Bleeding (Heyde's Syndrome). Report of Two Cases
Natowitz, L.; DEFRAIGNE, Jean ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1993), 93(1), 31-3

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent ... [more ▼]

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent small intestinal bleeding originating from angiodysplasia stopped after aortic valve replacement. We report two cases of patients presenting with a recurrent small intestinal bleeding originating from digestive angiodysplasia and suffering from aortic stenosis. Diagnosis of both pathologies is well documented in both cases. The replacement of the aortic valve by a biologic prosthesis stopped the bleeding. Prior to aortic valve replacement, the two patients suffered severe recurrent blood loss from intestinal angiodysplasia. The treatment of aortic stenosis greatly favored both cardiac and general status. We recommend aortic valve replacement with a biologic prosthesis prior to intestinal resection in patients presenting with Heyde's syndrome. We stress on the fact that anticoagulants must be stopped in order to minimize the risk of further bleeding. [less ▲]

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See detailPlasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro
Delree, P.; Ribbens, Clio ULg; Martin, Didier ULg et al

in Brain Research Bulletin (1993), 30(3-4), 231-7

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo ... [more ▼]

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo are also mentioned. Cultured developing and adult DRG neurons can be switched from an apolar to a multipolar phenotype by fetal calf serum or fibronectin. The effect is concentration dependent and occurs through an early modification of cell-substratum interaction. Adult DRG neurons synthesize and release within hours after injury TGF beta-1, which is a mitogen and a differentiation factor for Schwann cells. Finally, adult DRG neurons express in vitro neurotransmitters that are not expressed in vivo. This neurotransmitter plasticity can be modulated in vitro by some growth factors and in vivo by distal or proximal axotomy. [less ▲]

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See detailTHE CERTIFIED TOTAL GLUCOSINOLATE CONTENT IN 3 RAPESEEDS (CRM-190, CRM-366 AND CRM-367)
Wathelet, Jean-Paul ULg; WAGSTAFFE, P. J.; BOENKE, A. et al

in Fresenius' Journal of Analytical Chemistry (1993), 347(10-11), 396-399

The preparation of certified rapeseed reference materials and the steps taken to establish the certified values for total glucosinolate contents are described. Details are given of the studies to ... [more ▼]

The preparation of certified rapeseed reference materials and the steps taken to establish the certified values for total glucosinolate contents are described. Details are given of the studies to demonstrate the homogeneity and stability of the material. The results of the certification exercise for total glucosinolate content, which involved European laboratories who applied a variety of methods (high-pressure liquid chromatography, gas liquid chromatography, determination of enzymatically released glucose and sulphate), are presented and discussed. The certified values for the glucosinolate content (mumol/g of non-defatted whole seeds) and the 95% confidence level are the following: CRM 366 (12.1 +/- 0.8 mumol/g), CRM 190 (25.5 +/- 0.9 mumol/g) and CRM 367 (102.4 +/- 3 mumol/g) (CRM = certified reference material). Indicative values (not certified) for individual glucosinolates are also given. Certified sulphur values (mg/g of non defatted whole seeds) have been determined by other laboratories: CRM 366 (3.41 +/- 0.12 mg/g), CRM 190 (4.93 +/- 0.15 mg/g) and CRM 367 (10.5 +/- 0.40 mg/g). [less ▲]

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See detailNo significant effect of an "atraumatic" needle on incidence of post-lumbar puncture headache or traumatic tap.
Lenaerts, M.; Pepin, J. L.; Tombu, S. et al

in Cephalalgia : An International Journal of Headache (1993), 13(4), 296-7

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients ... [more ▼]

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients punctured with Sprotte's "atraumatic" needle. No significant difference was found between the two groups in incidence of headache or in frequency of traumatic taps. [less ▲]

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See detailSolid-state nuclear magnetic resonance studies of the transformation of the zeolite Y catalyst in the course of hydrochlorination of 1-methylcyclohexene by thionyl chloride
Kolodziejski, Waclaw; Delaude, Lionel ULg; Laszlo, Pierre ULg et al

in Applied Catalysis A : General (1993), 98(1), 71-79

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated ... [more ▼]

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated framework aluminium in the parent sample coexisting with a small amount of immobile extra-framework aluminium at ca. -1 ppm is completely removed after just one reaction run and transformed into two distinct 6-coordinated species resonating at 0.2 and -3.1 ppm. The former line is assigned to Al(H2O)63+ cations, the latter is likely to come from a species with mixed solvation shells, probably Al(Cl-)(H2O)52+ and Al(OH-)(H2O)52+. Crystallinity of the catalyst is seriously affected by the reaction. The spectra confirm that before reaction the zeolite contains Si(3Si,1OH) and Si(2Si,2OH) groups. During the reaction most hydroxyl groups created by dealumination are removed, although some Si(3Si,1OH) remain. MAS NMR spectra are fully consistent with the proposed reaction mechanism. [less ▲]

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See detailLe nom du bison en grec et en latin
Purnelle, Gérald ULg

in Latomus : Revue d'Etudes Latines (1993), 52(3), 567-580

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See detailNUCLEOPHILIC ENANTIOSELECTIVE SYNTHESIS OF 6-[F-18]FLUORO-L-DOPA VIA 2 CHIRAL AUXILIARIES
Lemaire, Christian ULg; Plenevaux, Alain ULg; Cantineau, Robert et al

in Applied Radiation & Isotopes (1993), 44(4), 737-744

Asymmetric nucleophilic synthesis of 6-[F-18]fluoro-L-dopa was investigated in order to reach an enantiomeric excess of close to 100% of the L form of this amino acid. The radiochemical synthesis required ... [more ▼]

Asymmetric nucleophilic synthesis of 6-[F-18]fluoro-L-dopa was investigated in order to reach an enantiomeric excess of close to 100% of the L form of this amino acid. The radiochemical synthesis required [F-18]fluoride as fluorinating agent and regioselective nucleophilic substitution of commercially available 6-nitroveratraldehyde. The [F-18]fluorobenzaldehyde thus obtained was easily converted to the corresponding 2-[F-18]fluoro-4,5-dimethoxybenzyl bromide. This alkylating agent was added to the lithium enolates of 1-(S)-(-)camphor imine of t-butyl glycinate (1) and (S)-(-)- 1 -Boc-2-t-butyl-3-methyl-4-imidazolidinone [(S)- Boc-BMI] (2) in order to compare the enantiomeric excess of the L form obtained in each case with these two chiral inductors. The L-isomer of fluorodopa was isolated after H1 hydrolysis and HPLC purification in 5-10% radiochemical yield (decay corrected). The overall synthesis time was of 110 min. Through this synthetic pathway, the L-isomer of fluorodopa was obtained in 83% e.e with 1 and 96% e.e with 2 respectively, as determined by chiral HPLC. A practical three step preparative scale synthesis of 6-[F-19]fluoro-D,L-dopa is also presented. [less ▲]

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See detailAnalgesic Efficiency of Propacetamol Hydrochlorid after Lumbar Disc Surgery
Hans, Pol ULg; Brichant, Jean-François ULg; Bonhomme, Vincent ULg et al

in Acta Anaesthesiologica Belgica (1993), 44(4), 129-33

The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients ... [more ▼]

The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients scheduled for lumbar disc surgery were randomly allocated to two groups. They were given either propacetamol 2 g or saline every 6 hours, starting at the end of procedure for a 24 hours period. The pain intensity (VAS) was not significantly different between the two groups except 3 and 4 hours after surgery, where it was higher in the paracetamol group. The cumulative narcotic consumption (piritramide on request) was higher in the placebo group from 6 hours till 9 hours after surgery but not significantly different after 24 hours. Piritramide administration decreased VAS score significantly in both groups while propacetamol reduced it in a significant way only when given from 12 hours after surgery. [less ▲]

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See detailA finite element code for subsidence problems: LAGAMINE
Charlier, Robert ULg; Radu, Jean-Pol ULg; Li, Q. F.

in Bulletin of Engineering Geology & the Environment (1993), 47(1 / avril), 5-11

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See detailPressure effects, kinetics, and rheology of anorthositic and related magmas
Longhi, John; Fram, Miranda; Vander Auwera, Jacqueline ULg et al

in American Mineralogist (1993), 78

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See detailExteroceptive suppression of temporalis muscle activity in patients with chronic headache and in normal volunteers: methodology, clinical and pathophysiological relevance.
Schoenen, Jean ULg

in Headache (1993), 33(1), 3-17

Exteroceptive suppression of temporalis muscle activity was studied in patients with chronic headache and in healthy controls. Among different methods of recording, averaging 10 full-wave rectified EMG ... [more ▼]

Exteroceptive suppression of temporalis muscle activity was studied in patients with chronic headache and in healthy controls. Among different methods of recording, averaging 10 full-wave rectified EMG responses produces results with acceptable variability and discomfort. The late temporalis exteroceptive suppression period (ES2) is reduced on average in patients with chronic tension-type headache; this finding has been reproduced by several independent laboratories. Mean duration of temporalis ES2 is also diminished, but to a lesser degree, in daily drug abuse headache and, as shown by others, in episodic tension-type headache. It is normal in migraine between attacks, cluster headache and various types of symptomatic headaches. Temporalis ES2 may be decreased in untreated patients with major depression. In healthy volunteers, temporalis ES2 duration is reduced by a short-lasting painful stimulus to peripheral limbs after a delay of 50 to 60 ms, and by a sub-motor threshold electromagnetic stimulation to the contralateral cerebral cortex after a delay of 20 to 30 ms. In contrast, long-lasting trains of peripheral painful stimuli have no effect. Various pharmacological agents are able to modify temporalis ES2. Its duration is increased by 5-HT antagonists, but decreased by 5-HT uptake blockers. Pharmacological effects may differ between controls and patients. Considering these results and available data on the anatomo-functional organization of masticatory reflexes, we postulate that temporalis ES2 is a marker of the excitability of interneuronal nets in the ponto-medullary reticular formation. In chronic tension-type headache, excitability of these interneurons is decreased because of inadequate control by the serotonergic raphe magnus nucleus and the periaqueductal gray matter. Dysfunctioning of the latter structures might be caused by abnormal limbic inputs to the brain stem. Some steps of this pathophysiological hypothesis can be verified by modern neurophysiological techniques. [less ▲]

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See detailRespiratory response to abdominal and rib cage muscle paralysis in dogs.
Brichant, Jean-François ULg; Gorini, Massimo; De Troyer, André

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1993), 74(5), 2309-17

To assess the respiratory response to abdominal and rib cage muscle paralysis, we measured tidal volume, esophageal and gastric pressures, arterial blood gases, and the electromyogram (EMG) of the ... [more ▼]

To assess the respiratory response to abdominal and rib cage muscle paralysis, we measured tidal volume, esophageal and gastric pressures, arterial blood gases, and the electromyogram (EMG) of the diaphragm during progressive epidural anesthesia (lidocaine 2%) in 35 supine anesthetized dogs. The EMG activity of the diaphragm was measured with fine-wire electrodes; the abdominal cavity was thus left intact. Paralysis of the abdominal muscles alone did not produce any alterations. In contrast, when all rib cage muscles were also paralyzed, there were substantial increases in the peak height and the rate of rise of diaphragmatic EMG activity that were associated with a decrease in tidal volume and an increase in arterial PCO2 (PaCO2); swings in transdiaphragmatic pressure, however, were unchanged. The increased diaphragmatic activation due to rib cage muscle paralysis persisted after bilateral cervical vagotomy and was well explained by the increased PaCO2. These observations indicate that in the dog 1) the rib cage muscles contribute significantly to tidal volume, and their paralysis causes, through the increased hypercapnic drive, a compensatory increase in diaphragmatic activation; and 2) the rib cage inspiratory muscles enhance the diaphragm's ability to generate pressure during breathing. [less ▲]

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See detailDetection of mRNA encoding an antibacterial-metalloprotein (MPII) by in situ hybridization with a cDNA probe generated by PCR in the worm nereis diversicolor
Salzet-Raveillon, B.; Rentier-Delrue, Françoise ULg; Dhainaut, A.

in Cellular and Molecular Biology (1993)

Based on partial amino acid sequence of an antibacterial-metalloprotein (MPII) consisting of a N-terminal fragment (1-33th) and an 43 amino acids long internal fragment, two oligonucleotides primers were ... [more ▼]

Based on partial amino acid sequence of an antibacterial-metalloprotein (MPII) consisting of a N-terminal fragment (1-33th) and an 43 amino acids long internal fragment, two oligonucleotides primers were synthesized and used to generate a cDNA fragment by the PCR method. The specificity of the PCR synthesized 220 bp fragment was verified by hybrid-arrest translation and sequencing. In situ hybridization performed with this cDNA fragment on Nereis diversicolor whole body defined two specific sites of recognition: a cluster of cells floating in the coelom and two types of muscles (perineural and oblique). Finally, the chronological expression of the MPII was postulated. [less ▲]

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See detailPalynological data from the Devono-Carboniferous boundary beds in the new Stockum Trench II and the Hasselbachtal Borehole. Northern Rhenish Massif, Germany.
Higgs, K; Streel, Maurice ULg; Korn, D et al

in Annales de la Société Géologique de Belgique (1993), 115(2/1992), 551-557

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See detailQuantitative estimation of chimerism in mice using microsatellite markers
Delhaise, F.; Zhao, X.; Dessy, F. et al

in Molecular Reproduction and Development (1993), 34(2), 127-132

An embryonic stem cell line was established from SV129 mouse blastocysts and used to generate chimeric mice by injection into OF1 blastocysts; 18 out of the 30 resulting offspring appeared chimeric as ... [more ▼]

An embryonic stem cell line was established from SV129 mouse blastocysts and used to generate chimeric mice by injection into OF1 blastocysts; 18 out of the 30 resulting offspring appeared chimeric as judged from their coat color patterns, and 3 of the 13 males proved to be germ-line chimeras as they transmitted the SV129 agouti phenotype to all or part of their offspring. The degree of chimerism of these males was evaluated for different tissues using polymorphic microsatellite markers amplified by the polymerase chain reaction. It was shown that these new markers can be effectively used to quantitatively estimate levels of chimerism. The CKMM (creatine kinase, muscle) microsatellite system was used to distinguish the SV129 from the OF1 genotype. In all performed tests, the correlation between DNA ratio and signal ratio, expressed as a base 10 logarithm, was shown to exceed or equal 0.98 for known DNA ratios (SV129/OF1) ranging from 1/99 to 99/1. Linear calibration methods were used to predict the % SV129 DNA of a test sample based on the obtained signal ratio. The accuracy of the prediction was evaluated by performing repeated measurements. Differences among three repeated estimates ranged from 2 to 17% for a given sample. Microsatellite systems should be very useful to monitor chimerism involving strains that can not be discerned with coat color or biochemical markers. This will be particularly important when ES methodology becomes available in species other than mice. [less ▲]

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See detailQuantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin.
Beguin, Yves ULg; Clemons, G. K.; Pootrakul, P. et al

in Blood (1993), 81(4), 1067-76

We evaluated the quantitative value of a simple model of erythropoiesis, based on the basic assumptions that the red blood cell (RBC) mass determines erythropoietin (Epo) production, which in turn ... [more ▼]

We evaluated the quantitative value of a simple model of erythropoiesis, based on the basic assumptions that the red blood cell (RBC) mass determines erythropoietin (Epo) production, which in turn stimulates erythropoietic activity. The RBC mass was quantitated by direct isotopic measurement (RCM), Epo production by serum Epo levels, and erythropoiesis by the ferrokinetic measurement of the erythron transferrin uptake (ETU), the serum transferrin receptor (TfR) level, and the reticulocyte (retic) index, and was completed by an evaluation of overall marrow erythron cellularity. We studied a total of 195 subjects, including 31 normal individuals, 38 patients with polycythemia, and 126 patients with various forms of anemia. Instead of only quantitating Epo and erythropoiesis in absolute terms, we also evaluated them in relation to the degree of anemia or polycythemia, and expressed the results as a ratio of observed values to values predicted from the regression equations between hematocrit (Hct) on the one hand, and Epo, TfR, and ETU on the other, obtained in a carefully selected subpopulation. The slope of the regression of TfR (as well as ETU) versus Hct was very similar to the slope of the regression of Epo versus Hct. Average EPO and TfR (as well as ETU) values predicted from the regression equations were quite comparable to observed values in most groups of subjects, with exceptions predictable from knowledge of the pathophysiology of these hematologic disorders. We identified four major patterns of erythropoiesis, ie, normal, hyperdestruction (with variants of hemolysis or ineffective erythropoiesis), intrinsic marrow hypoproliferation, and defective Epo production. Dissecting out groups of patients showed much greater heterogeneity than when patients were analyzed by group. This was particularly true in the case of a hypoproliferative component being combined with hyperdestruction, giving what we called a "mixed disorder of erythropoiesis." We conclude that the pathophysiology of anemia can be assessed by a simple measurement of Hct, retic index, Epo, and TfR levels, with Epo and TfR being more informative when expressed in relation to the degree of anemia. The model is particularly useful for detecting the presence of multiple mechanisms of anemia in the same patient. However, it has limitations inherent to the relative invalidity of TfR in iron deficiency, the imprecision of a retic count, and the difficulty in distinguishing hemolysis from ineffective erythropoiesis in some patients and in recognizing a component of hyperdestruction in hypoproliferative anemia. [less ▲]

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See detailComment assurer efficacement le dépistage de l'ostéoporose ?
Reginster, Jean-Yves ULg

in Lettre du Rhumatologue (La) (1993), 196

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See detailL'ostéoporose
Reginster, Jean-Yves ULg

in Medipractice Digest (1993)

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See detailTEM investigation of transition phases precipitation in ZA alloys after isothermal aging at 250°C and subsequent creep at high temperature
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Wegria, J.

in Materials Science Forum (Intergranular and Interphase Boundaries in Materials) (1993), 126-128

Transition phases occurring during isothermal aging at 250°C af ternary Zri-A1-Cu alloys are modlifîed after creep at high temperature. fle pressure applkd during creep leads to a high dertsity of clef ... [more ▼]

Transition phases occurring during isothermal aging at 250°C af ternary Zri-A1-Cu alloys are modlifîed after creep at high temperature. fle pressure applkd during creep leads to a high dertsity of clef ects which modifies the ndcrostructure. 11e trnsitiôn phases are studied by me ans of transmission electron microscopy and diffraction technique. Œ’r and phases pile up on dislocations. 11e reaction «s + £ 4 T +r 1$ accelerated and the transition T’ -. e’ is proxnoted by the defects. [less ▲]

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See detailContingent negative variation: methods and potential interest in headache.
Schoenen, Jean ULg; Timsit-Berthier, M.

in Cephalalgia : An International Journal of Headache (1993), 13(1), 28-32

Contingent negative variation (CNV) is an event-related slow cerebral potential which has been found abnormal in migraine. Its methodology is described. Contrary to other neurophysiological techniques ... [more ▼]

Contingent negative variation (CNV) is an event-related slow cerebral potential which has been found abnormal in migraine. Its methodology is described. Contrary to other neurophysiological techniques, CNV needs special equipment and expertise. On average, CNV amplitude is increased and its habituation is lacking in migraine without aura between attacks, but not in migraine with aura. The sensitivity of CNV as a diagnostic tool is low, but its specificity is high. CNV amplitude normalizes after treatment with beta-blockers. The CNV abnormalities in migraine might be due to hyperreactivity of central catecholaminergic pathways. [less ▲]

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See detailMeasurement of the 2s2p2(4P)3s 3P2 lifetime in N II by beam-foil-laser spectroscopy
Bastin, Thierry ULg; Baudinet-Robinet, Y.; Garnir, Henri-Pierre ULg et al

in Journal Physical II (1993), 3

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the ... [more ▼]

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the beam-foil lifetime values reported previously for the 3s' 3P term. No theoretical value for the lifetime of this term is available at the present time. [less ▲]

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See detailPalynological age for the lower part of the Hangenberg Shales in Sauerland, Germany
Higgs, K; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1993), 116(Z), 243-247

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See detailBIOLOGICAL-ACTIVITY OF THE SHRUB BOSCIA-SENEGALENSIS (PERS) LAM EX-POIR (CAPPARACEAE) ON STORED GRAIN INSECTS
SECK, D.; Lognay, Georges ULg; Haubruge, Eric ULg et al

in Journal of Chemical Ecology (1993), 19(2), 377-389

Biological activity of leaves, fruits and extract of the African shrub Boscia senegalensis (PERS.) LAM. ex Poir. was evaluated against five stored-grain insects. When added to cowpeas at 2-4% (w/w), fresh ... [more ▼]

Biological activity of leaves, fruits and extract of the African shrub Boscia senegalensis (PERS.) LAM. ex Poir. was evaluated against five stored-grain insects. When added to cowpeas at 2-4% (w/w), fresh ground fruits and leaves caused 80-100% mortality in Callosobruchus maculatus (F.) adults and significantly reduced both emergence and damage of the F1 progeny. Acetone fruit extract exhibited a potent fumigant effect on Prostephanus truncatus HORN., C maculatus, and Sitotroga cerealella OLIV.: with LT50 values of 3.8, 2.3, and below 1.5 hr, respectively. LC50 determination for B. senegalensis fruits and leaves as well as pure methylisothiocyanate (MITC) on Tribolium castaneum HERBST, Sitophilus zeamais MOTSCH. and C. maculatus showed a differential response of the insects to plant parts or MITC. Quantitative dosage of Boscia active components and LC50 values obtained for the plant tissues, compared to those of pure molecules, indicate that the biological activity of B. senegalensis is due to the liberation of MITC from a glucosinolate precursor glucocapparin contained in Boscia fruits and leaves. [less ▲]

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See detailThe Appearance of C2H3+ Ions from C2H3F by non-resonant Photoionization. A Translational Energy Surprisal Analysis.
Momigny, J.; Locht, Robert ULg

in Chemical Physics Letters (1993), 211(2,3), 161-165

It is shown that for a photon energy of 16.85 eV the translational energy surprisal of the C2H3++F dissociation products from C2H3F+ has a bimodal behaviour. The possibility of considering the bimodal ... [more ▼]

It is shown that for a photon energy of 16.85 eV the translational energy surprisal of the C2H3++F dissociation products from C2H3F+ has a bimodal behaviour. The possibility of considering the bimodal surprisal as due to the superposition of two translational energy distributions is consistent with the theoretical assumption of the concurrence of two channels in this dissociation process. The characteristics of these distributions, i.e. the energy width and the relative abundance, are in agreement with the results of an ab initio quantum-mechanical calculation of the dynamics of this dissociation. They are consistent with the simultaneous occurrence of a statistical dissociation of C2H3F+(X2A') into C2H3+(X1A') and an isolated state dissociation of C2H3F+(C2A") into C2H3+(a3A"). Negative lambda values obtained for the surprisal of both these distributions indicate an inversion of the translational level population of the dissociation products. [less ▲]

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See detailMicrosatellite mapping of a gene affecting horn development in Bos taurus
Georges, Michel ULg; Drinkwater, R.; Lefort, A. et al

in Nature Genetics (1993), 4(2), 206-210

The presence or absence of horns in Bos taurus is thought to be under the genetic control of the autosomal polled locus, characterized by two alleles: P dominant over p, and causing the polled or hornless ... [more ▼]

The presence or absence of horns in Bos taurus is thought to be under the genetic control of the autosomal polled locus, characterized by two alleles: P dominant over p, and causing the polled or hornless phenotype. We have demonstrated genetic linkage between the polled locus and two microsatellite markers, GMPOLL-1 and GMPOLL-2, and have assigned the corresponding linkage group to bovine chromosome 1. This confirms the existence of the postulated polled locus and the hypothesized inheritance pattern. It will allow marker assisted selection for the polledness trait in breeding programs and is a first step towards positional cloning and molecular study of a gene that has been subjected to both natural and artificial selection. [less ▲]

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See detailEvidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
Geenen, Vincent ULg; Achour, Imane; Robert, Françoise et al

in Thymus (1993), 21(2), 115-127

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human ... [more ▼]

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human thymic insulin-related self antigen able to represent the pancreatic islet ß cell function in face of the developing T cells. Immunofluorescence studies were performed on human and rat thymic sections, as wess as on the rat IT-45R1 thymic epithelial cell line using several antibodies to epitopes of the insulin peptide family. These studies identify beyond any doubt that IGF2 is the dominant thymic peptide of the insulin family. The sequence of an insulin-derived autoantigen is proposed. This autoantigen is a nonamer and has a hydrophobic residue leucine at position 9. In human species, this autoantigen would primarily be tolerogenic for the pancreatic ß-cell endocrine function during fetal development. [less ▲]

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See detailMicrosatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated QTL
Georges, Michel ULg; Lathrop, M.; Dietz, A. B. et al

in Proceedings of the National Academy of Sciences of the United States of America (1993), 90

A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from ... [more ▼]

A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from a pleiotropic effect of a single gene, or from linkage disequilibrium between the gene causing weaver disease and a quantitative trait locus (QTL) for milk production. To test these hypotheses, we performed an extensive linkage study in a bovine pedigree segregating for the weaver condition and identified a microsatellite locus (TGLA116) closely linked to the weaver gene (zmax, 8.15; theta, 0.03). TGLA116 and, by extension, the weaver locus were assigned to bovine synteny group 13. This microsatellite can be used to identify weaver carriers, to select against this genetic defect, and to study the effect of the corresponding chromosomal region on milk production in Brown Swiss and other breeds of cattle. [less ▲]

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See detailLa saisie électronique des données en forêt : réalités et perspectives
Rondeux, Jacques ULg

in Revue Forestière Française (1993), 45(n° sp), 20-26

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See detailIn vivo infection of sheep by bovine leukemia virus mutants.
Willems, Luc ULg; Kettmann, Richard ULg; Dequiedt, Franck ULg et al

in Journal of virology (1993), 67(7),

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See detailEvaluation of efficacy and safety of oral tiludronate in Paget's disease of bone: a double-blind, dose-ranging, placebo-controlled study
Reginster, Jean-Yves ULg; Colson, F; Morlock, G et al

in Arthritis and Rheumatism (1993), 36

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See detailConstruction of a bovine genomic library of large yeast artificial chromosome clones
Libert, F.; Lefort, A.; Okimoto, R. et al

in Genomics (1993), 18(2), 270-276

We have constructed a yeast artificial chromosome (YAC) library derived from bull fibroblasts in primary culture. The library consists of 21,500 clones arranged on 224 gridded plates (96 or 8×12 positions ... [more ▼]

We have constructed a yeast artificial chromosome (YAC) library derived from bull fibroblasts in primary culture. The library consists of 21,500 clones arranged on 224 gridded plates (96 or 8×12 positions) and in 2×224 96-well microplates maintained as permanent frozen stocks. An average insert size of 750 kb was estimated from the analysis of 200 randomly selected YACs, giving a sixfold coverage of the bovine genome for the total library. A screening strategy based on the polymerase chain reaction that allows the identification of individual clones has been devised. Screening of the library with six locus-specific markers of interest led to the isolation of 34 positive clones [less ▲]

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See detailEl analisis estructural semi-rigido: definicion, camp y mood de applicacion
Jaspart, Jean-Pierre ULg; Maquoi, René ULg

in Construcciones Metalicas y Caldereria (1993), 28

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See detailNew gamma-lactam homologs of penems
Marchand-Brynaert, Jacqueline; Couplet, Blandine; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry Letters (1993), 3(11), 2303-2308

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See detailSTUDY OF THE CRYSTALLIZATION PROCESS IN BI2-XPBXSR2CA2CU3O10-Y GLASS SYSTEMS - OPTICAL POLARIZED-LIGHT MICROSCOPY, ELECTRICAL AND MAGNETIC-PROPERTIES
Cloots, Rudi ULg; Romain, Anne-Claude ULg; Rulmont, André ULg et al

in Superconductor Science & Technology (1993), 6(12), 850-857

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C ... [more ▼]

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C for 96 or 144 h (with one intermediary grinding). High-resolution polarization micrographs and electrical (and magnetic susceptibility) measurements have been taken. Various growth mechanisms can thus be checked, and the physical properties are studied in relation to the microstructure. It is found that the 2223 phase does not crystallize directly from the amorphous one but results from a dissolution-reprecipitation process. The stability of the 2212 phase is emphasized. The 2201 phase precipitates at high temperature and rapidly reacts with the melt to form the 2223 phase. The kinetics of the lead-substituted sample seems to be controlled by the Ca2PbO4 phase. which acts as a flux. [less ▲]

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See detailEtude comparative des formules d'interaction poutre-poteau
Jaspart, Jean-Pierre ULg; Briquet, C.; Maquoi, René ULg

in Construction Métallique (1993), n°4

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See detailHomologous recombinant growth hormone and calcium metabolism in the tilapia oreochromis mossambicus, adapted to freshwater
Flik, G.; Atsma, W.; Fenwick, J. C. et al

in Journal of Experimental Biology (1993)

Homologous recombinant tilapia growth hormoe was tested for its effect on calcium metabolism in freshwater tilapia Oreochromis mossambicus. A comparison of the role of GH and prolactin in calcium ... [more ▼]

Homologous recombinant tilapia growth hormoe was tested for its effect on calcium metabolism in freshwater tilapia Oreochromis mossambicus. A comparison of the role of GH and prolactin in calcium regulation of the tilapia led to the conclusion that GH has specific calciopropic effects on freshwater Tilapia that differ from those of prolactin. [less ▲]

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See detailadministration en dose unique journalière de l'amikacine. Adaptation à la néonatalogie pour des enfants traités avant le 3° jour d'âge postnatal
Battisti, Oreste ULg; Langhendries, J. P.; Bertrand, J. M. et al

in Médecine et Maladies Infectieuses (1993), 23

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