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See detail5-HT1A dysfunction in borderline personality disorder.
Hansenne, Michel ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in Psychological Medicine (2002), 32(5), 935-41

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used ... [more ▼]

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used in these studies since fenfluramine and m-CPP are not only serotonergic agents but also induce release of catecholamines, particularly dopamine. Therefore, we tested whether subjects with BPD showed a blunted prolactin (PRL) response to flesinoxan, a highly potent and selective 5-HT1A agonist. METHODS: Flesinoxan challenge test was carried out in 20 BPD in-patients and 20 healthy controls matched for gender but not for age. Since 16 BPD in-patients exhibited major depressive co-morbidity, a group of 20 depressed in-patients matched for gender but not for age was also included. RESULTS: BPD in-patients exhibited blunted PRL responses as compared to controls, whereas depressed in-patients did not differ from controls. Moreover, PRL responses were lower among BPD in-patients than among depressed in-patients. Among the BPD in-patients, PRL responses to flesinoxan were lower in patients with past history of suicide attempts (N = 8) than in those with a negative history. CONCLUSIONS: The results show major involvement of serotonergic function in BPD and are consistent with previous studies linking lower serotonergic activity with impulsivity. More particularly, our data suggest that BPD is characterized by lower 5-HT1A receptor sensitivity. Moreover, the data support the involvement of 5-HT1A activity in suicidal behaviour. However, this conclusion is limited because other hormonal responses such as ACTH and cortisol were not assessed, and because BPD was assessed by a self-report questionnaire and not a structured clinical interview. [less ▲]

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See detailIsolement et caractérisation de l'ostéocalcine équine
Carstanjen, Bianca; Wattiez, R.; Amory, Hélène ULg et al

in Annales de Médecine Vétérinaire (2002), 146

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the ... [more ▼]

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the purification procedure was based on reverse phase chromatography, gel filtration and ion exchange chromatography. The amino acid sequence of the primary structure has been determined to be YLDHWLGA(HYP) APYPDPL(GLA)PRR(GLA)VC (GLA)LNPDCDELADHIGF-AYRRFYGPV. The protein has a calculated molecular weight of 5,732 kDa and a calculated isoelectric point of 4,45. It contains 49 amino acids, from which 3 are gamma-carboxyglutamic acid residues at position 17, 21 and 24 and has a fully hydroxylated proline in position nine and cysteine in position 23 and 29. Equine osteocalcin shows a strong homology with bovine (98%), ovine (96%) and human (94%) osteocalcin [less ▲]

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See detailJuvenile acanthosis nigricans and insulin resistance.
Hermanns-Lê, Trinh ULg; Hermanns, Jean-François ULg; Pierard, Gérald ULg

in Pediatric Dermatology (2002), 19(1), 12-4

Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. In the early stage the skin lesions appeared to be ... [more ▼]

Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. In the early stage the skin lesions appeared to be erythematous and pruritic, mimicking an inflammatory dermatitis. Dietary control and oral metformin hydrochloride markedly improved the lesions. Topical calcipotriol may also help to control the skin condition. [less ▲]

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See detailLa châsse de saint Remacle (1263-1268) et Liège
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (2002), t. XIV, n° 298-299

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See detailDetermination of a coalescence parameter from batch-settling experiments
Henschke, M; Schlieper, L; Pfennig, Andreas ULg

in Chemical Engineering Journal (2002), 85((2-3)), 369-378

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See detailUnusual traits of the pyoverdin-mediated iron acquisition system in Pseudomonas putida strain BTP1.
Ongena, MARC ULg; Jacques, Philippe ULg; Delfosse, Philippe et al

in Biometals (2002), 15(1), 1-13

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin ... [more ▼]

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin, Pseudomonas putida strain BTP1 could represent a valuable tool in an attempt to correlate the structural features of these compounds with some specificity in their two main properties i.e. affinity for iron and recognition rate by other Pseudomonas strains. An uncommonly high affinity for iron of the pyoverdin synthetized by P. putida BTP1 was observed by comparing both the apparent stability constant and the decomplexation kinetic of its ferric complex with those of ferripyoverdins from other strains. On another hand, results from growth stimulation experiments and labeled ferripyoverdin uptake assays highlighted the very low recognition rate of BTP1 isopyoverdins by membrane receptors of foreign strains. By contrast, P. putida BTP1 was able to utilize a broad spectrum of structurally unrelated exogenous pyoverdins by means of multiple receptors that are likely constitutively expressed in its outer membrane. The unusual traits of its pyoverdin-mediated iron acquisition system should contribute to enlarge the ecological competence of Pseudomonas putida BTP1 in terms of colonization and persistence in the rhizosphere. [less ▲]

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See detailRecommendations for a standardized report for adult transthoracic echocardiography: a report from the American Society of Echocardiography's Nomenclature and Standards Committee and Task Force for a Standardized Echocardiography Report.
Gardin, Julius M.; Adams, David B.; Douglas, Pamela S. et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2002), 15(3), 275-90

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See detailVoir les pyramides et en ramener un souvenir.
Fraiture, A. L.; Braham, Catherine; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2002), 69

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See detailL'image du mois. Une tumeur du cuir chevelu révélatrice d'une naevomatose basocellulaire.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(4), 185-6

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See detailEnergy Partitioning Between Latent And Sensible Heat Flux During The Warm Season At Fluxnet Sites
Wilson, Kell B.; Baldocchi, Dennis D.; Aubinet, Marc ULg et al

in Water Resources Research (2002), 38(12),

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See detailIconographies de saints mosans : Liège, ULG Wittert 82
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (2002)

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See detailObesity and liver disease.
Scheen, André ULg; Luyckx, Françoise ULg

in Best practice & research. Clinical endocrinology & metabolism (2002), 16(4), 703-16

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and ... [more ▼]

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. The identification of obese patients who may progress from steatosis to NASH and from NASH to fibrosis/cirrhosis is an important clinical challenge. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by a remarkable regression of liver steatosis in most patients, although increased inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome, and perhaps being part of it, especially in obese patients. [less ▲]

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See detailA role for the Clostridium perfringens beta 2 toxin in bovine enterotoxaemia?
Manteca, Christophe; Daube, Georges ULg; Jauniaux, Thierry ULg et al

in Veterinary Microbiology (2002), 86(3), 191-202

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and ... [more ▼]

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and haemorrhagic enteritis. The purpose of this study was to investigate the putative role of the more recently described beta2 toxin. Seven hundred and fourteen non-enterotoxigenic type A C. perfringens isolated from 133 calves with lesions of enterotoxaemia and high clostridial cell counts (study population) and 386 isolated from a control population of 87 calves were tested by a colony hybridisation assay for the beta2 toxin. Two hundred and eighteen (31%) C perfringens isolated from 83 calves (62%) of the study population and 113 (29%) C. perfringens isolated from 51 calves (59%) of the control population tested positive with the beta2 probe. Pure and mixed cultures of four C perfringens (one alpha+beta2+, one alpha+enterotoxin-1 and two alpha+) were tested in the ligated loop assay in one calf. Macroscopic haemorrhages of the intestinal wall, necrosis and haemorrhages of the intestinal content, and microscopic lesions of necrosis and polymorphonuclear and mononuclear cell infiltration of the intestinal villi were more pronounced in loops inoculated with the a and beta2-toxigenic C. perfringens isolate. These results suggest in vivo synergistic role of the alpha and beta2 toxins in the production of necrotic and haemorrhagic lesions of the small intestine in cases of bovine enterotoxaemia. However, isolation of beta2-toxigenic C. perfringens does not confirm the clinical diagnosis of bovine enterotoxaemia and a clostridial cell counts must still be performed. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailQuelques tournures péjoratives dans le débat philosophiques en sanskrit
Verpoorten, Jean-Marie ULg

in Indologica Taurinensia (2002)

Répertoire de 48 termes méprisants ou insultants utilisés par des philosophes antagonistes pour qualifier leurs adversaires et leurs doctrines. On notera d’ailleurs qu’il existe également des auteurs qui ... [more ▼]

Répertoire de 48 termes méprisants ou insultants utilisés par des philosophes antagonistes pour qualifier leurs adversaires et leurs doctrines. On notera d’ailleurs qu’il existe également des auteurs qui écrivent leurs œuvres en igorant toute polémique et toute attaque personnelle. Ainsi Maņḍanamiśra (vers 700.). D’autres, au nombre de 26 ci-après, se laissent aller à la critique personnelle (sans d’ailleurs citer l’opposant par son nom) et à l’invective. L’article énumère les mots ainsi utilisés dans l’ordre alphabétique du sanskrit et y joint un bref commentaire. Voici quelques exemples. Le bouddhiste Dignāga décrit ses adversaires comme de « mauvais logiciens » (kutarka) imbus de leurs vues erronées (abhimāna). Tout en utilisant le terme de « votre honneur » (āyuṣmant , tatrabhavant) , on traitera l’opposant de « fou » (unmatta, jaḍa, mūrkha, pramatta, manda, mūḍha), de « gosse » (bāla), d’ « animal » (paśu). A noter l’expression devānāṃpriya « chéri des dieux » synonyme de « fou », qui équivaut mutatis mutandis à « imbécile heureux ». On peut ajouter des expressions d’indignation et de mépris comme « ah, la grande folie ! propos totalement stupide, propos d’aveugle, divagation, énormité ». [less ▲]

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See detailThe flowering process: On the track of controlling factors in Sinapis alba
Bernier, Georges ULg; Corbesier, Laurent; Périlleux, Claire ULg

in Russian Journal of Plant Physiology (2002), 49(4, JUL-AUG), 445-450

The major physiological theories of the control of the flowering process are first presented and their inferences tested in the long-day plant Sinapis alba. Then, the genetic analyses of the control of ... [more ▼]

The major physiological theories of the control of the flowering process are first presented and their inferences tested in the long-day plant Sinapis alba. Then, the genetic analyses of the control of flowering time in Arabidopsis thaliana are also summarized with a brief overview of the several pathways, each including several genes, identified. Clearly, both the experimental data of physiological experiments and the multiplicity of interacting genetic pathways best support the theory of the multifactorial control of flowering. This is further shown by the fact that a critical gene expressed in the shoot meristem at floral transition in S. alba, MADS A (orthologous to A. thaliana SOC1), can be upregulated by a single dose of a cytokinin or a gibberellin, without leading to flowering. This indicates that the floral shift requires upregulation of other genes by other factors. [less ▲]

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See detailOntología y fenomenología en el pensamiento de Saussure
Badir, Sémir ULg

in Topicos del Seminario (2002), 8

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See detailCharacterization Of Kenyan Isolates Of Fusarium Udum From Pigeonpea [Cajanus Cajan (L.) Millsp.] By Cultural Characteristics, Aggressiveness And Aflp Analysis
Kiprop, E. K.; Baudoin, Jean-Pierre ULg; Mwang'Ombe, A. W. et al

in Journal of Phytopathology-Phytopathologische Zeitschrift (2002), 150

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See detailMeasurements Of The Horizontal Sprayer Boom Movements By Sensor Data Fusion
Ooms, David ULg; Lebeau, Frédéric ULg; Ruter, R. et al

in Computers and Electronics In Agriculture (2002), 33(2),

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See detailBa distribution in surface Southern Ocean sediments and export production estimates
Fagel, Nathalie ULg; Dehairs, Frank; André, Luc ULg et al

in Paleoceanography (2002), 17(2, MAR-JUN),

[1] We present excess Ba (Baxs) data (i.e., total Ba corrected for lithogenic Ba) for surface sediments from a north-south transect between the Polar Front Zone and the northern Weddell Gyre in the ... [more ▼]

[1] We present excess Ba (Baxs) data (i.e., total Ba corrected for lithogenic Ba) for surface sediments from a north-south transect between the Polar Front Zone and the northern Weddell Gyre in the Atlantic sector and between the Polar Front Zone and the Antarctic continent in the Indian sector. Focus is on two different processes that affect excess Ba accumulation in the sediments: sediment redistribution and excess Ba dissolution. The effect of these processes needs to be corrected for in order to convert accumulation rate into vertical rain rate, the flux component that can be linked to export production. In the Southern Ocean a major process affecting Ba accumulation rate is sediment focusing, which is corrected for using excess Th-230. This correction, however, may not always be straightforward because of boundary scavenging effects. A further major process affecting excess Ba accumulation is barite dissolution during exposure at the sediment-water column interface. Export production estimates derived from excess Th-230 and barite dissolution corrected Baxs accumulation rates (i.e., excess Ba vertical rain rates) are of the same magnitude but generally larger than export production estimates based on water column proxies (Th-234-deficit in the upper water column; particulate excess Ba enrichment in the mesopelagic water column). We believe export production values based on excess Ba vertical rain rate might be overestimated due to inaccurate assessment of the Baxs preservation rate. Barite dissolution has, in general, been taken into account by relating it to exposure time before burial depending on the rate of sediment accumulation. However, the observed decrease of excess Ba content with increasing water column depth (or increasing hydrostatic pressure) illustrates the dependence of barite preservation on degree of saturation in the deep water column in accordance with available thermodynamic data. Therefore correction for barite dissolution would not be appropriate by considering only exposure time of the barite to some uniformly undersaturated deep water but requires also that regional differences in degree of undersatuation be taken into account. [less ▲]

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See detailExistence de karsts en roches cristallines silicatées non carbonatées en Afrique sahélienne et équatoriale, implications hydrogéologiques
Willems, Luc ULg; Pouclet, André; Vicat, Jean-Paul

in Bulletin de la Société Géologique de France (2002), 173(4), 337-345

Various cavities studied in western Niger and South Cameroon show the existence of important karstic phenomena into metagabbros and gneisses. These large-sized eaves resulted from generalized dissolution ... [more ▼]

Various cavities studied in western Niger and South Cameroon show the existence of important karstic phenomena into metagabbros and gneisses. These large-sized eaves resulted from generalized dissolution of silicate formations in spite of their low solubility. Karstification is produced by deep hydrous transfer along lithological discontinuities and fracture net works. The existence of such caves has major implications in geomorphology, under either Sahelian and Equatorial climate, and in hydrogeology and water supply, particularly in the Sahel area. [less ▲]

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See detailPseudomonas aeruginosa displays an epidemic population structure.
Pirnay, Jean-Paul; De Vos, Daniel; Cochez, Christel et al

in Environmental microbiology (2002), 4(12), 898-911

Bacteria can have population structures ranging from the fully sexual to the highly clonal. Despite numerous studies, the population structure of Pseudomonas aeruginosa is still somewhat contentious. We ... [more ▼]

Bacteria can have population structures ranging from the fully sexual to the highly clonal. Despite numerous studies, the population structure of Pseudomonas aeruginosa is still somewhat contentious. We used a polyphasic approach in order to shed new light on this issue. A data set consisting of three outer membrane (lipo)protein gene sequences (oprI, oprL and oprD), a DNA-based fingerprint (amplified fragment length polymorphism), serotype and pyoverdine type of 73 P. aeruginosa clinical and environmental isolates, collected across the world, was analysed using biological data analysis software. We observed a clear mosaicism in the results, non-congruence between results of different typing methods and a microscale mosaic structure in the oprD gene. Hence, in this network, we also observed some clonal complexes characterized by an almost identical data set. The most recent clones exhibited serotypes O1, 6, 11 and 12. No obvious correlation was observed between these dominant clones and habitat or, with the exception of some recent clones, geographical origin. Our results are consistent with, and even clarify, some seemingly contradictory results in earlier epidemiological studies. Therefore, we suggest an epidemic population structure for P. aeruginosa, comparable with that of Neisseria meningitidis, a superficially clonal structure with frequent recombinations, in which occasionally highly successful epidemic clones arise. [less ▲]

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See detailPaedomorphosis in the Alpine newt (Triturus alpestris): decoupling behavioural and morphological change
Denoël, Mathieu ULg

in Behavioral Ecology and Sociobiology (2002), 52(5), 394-399

Paedomorphosis is a heterochronic pattern leading to morphological change, i.e. retention of larval characters in the adult phenotype. The aim of this study was to find out whether behaviour and ... [more ▼]

Paedomorphosis is a heterochronic pattern leading to morphological change, i.e. retention of larval characters in the adult phenotype. The aim of this study was to find out whether behaviour and morphology are decoupled in heterochronic phenotypes. To this end, I compared qualitative and quantitative aspects of courtship behaviour in syntopic metamorphic and paedomorphic Alpine newts, Triturus alpestris. Morphologically, the two morphs differ considerably (e.g. by the presence of gills only in paedomorphs), but their patterns of sexual behaviours are exhibited at similar frequencies and males use the same alternative reproductive tactics to attract unresponsive females. These results show that morphology and behaviour follow different ontogenetic pathways and are thus decoupled. Decoupling of the two traits offers the possibility of morphological evolution without alteration of sexual patterns. [less ▲]

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See detailClassical and Bayesian inference in neuroimaging : Theory
Friston, Karl J; Penny, W.; Phillips, Christophe ULg et al

in Neuroimage (2002), 16(2), 465-483

This paper reviews hierarchical observation models, used in functional neuroimaging, in a Bayesian light. It emphasizes the common ground shared by classical and Bayesian methods to show that conventional ... [more ▼]

This paper reviews hierarchical observation models, used in functional neuroimaging, in a Bayesian light. It emphasizes the common ground shared by classical and Bayesian methods to show that conventional analyses of neuroimaging data can be usefully extended within an empirical Bayesian framework. In particular we formulate the procedures used in conventional data analysis in terms of hierarchical linear models and establish a connection between classical inference and parametric empirical Bayes (PEB) through covariance component estimation. This estimation is based on an expectation maximization or EM algorithm. The key point is that hierarchical models not only provide for appropriate inference at the highest level but that one can revisit lower levels suitably equipped to make Bayesian inferences. Bayesian inferences eschew many of the difficulties encountered with classical inference and characterize brain responses in a way that is more directly predicated on what one is interested in. The motivation for Bayesian approaches is reviewed and the theoretical background is presented in a way that relates to conventional methods, in particular restricted maximum likelihood (ReML). This paper is a technical and theoretical prelude to subsequent papers that deal with applications of the theory to a range of important issues in neuroimaging. These issues include; (i) Estimating nonsphericity or variance components in fMRI time-series that can arise from serial correlations within subject, or are induced by multisubject (i.e., hierarchical) studies. (ii) Spatiotemporal Bayesian models for imaging data, in which voxels-specific effects are constrained by responses in other voxels. (iii) Bayesian estimation of nonlinear models of hemodynamic responses and (iv) principled ways of mixing structural and functional priors in EEG source reconstruction. Although diverse, all these estimation problems are accommodated by the PEB framework described in this paper. [less ▲]

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See detailStrontium ranelate in osteoporosis
Reginster, Jean-Yves ULg

in Current Pharmaceutical Design (2002), 8

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See detailInitiation à une pédagogie active de l'éveil scientifique : analyse d'une démarche d'observation en formation continuée d'enseignants
Geurden, Christine; Hanck, Marianne; Giot, Bernadette ULg et al

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 9-10

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See detailRandomized controlled study of the influence of two low estrogen dose oral contraceptives containing gestodene or desogestrel on carbohydrate metabolism.
Ludicke, Frank; Gaspard, Ulysse ULg; Demeyer, Fabienne ULg et al

in Contraception (2002), 66(6), 411-5

This study compared the impact on carbohydrate metabolism of two combinedoral contraceptives (COCs). This open-label, single-center trial enrolled participants for a total of 15 cycles. Thirty-six women ... [more ▼]

This study compared the impact on carbohydrate metabolism of two combinedoral contraceptives (COCs). This open-label, single-center trial enrolled participants for a total of 15 cycles. Thirty-six women were randomized to receive either 20 microg ethinyl estradiol (EE) and 75 microg gestodene (GSD) or 20 microg ethinyl estradiol and 150 microg desogestrel (DSG) daily for 21 days out of 28. A glucose tolerance test was performed at baseline and cycles 6 and 13. The area under the curve (AUC) for glucose increased in both study groups. The change was statistically significant (p = 0.036) for the 20 EE/75 GSD group at cycle 6 versus baseline. Fasting blood glucose at cycle 13 was significantly (p < 0.01) higher for both treatment groups compared to baseline. No changes were found for fasting insulin and fasting C-peptide levels or for the AUCs of insulin or C-peptide. Both regimens were well tolerated. Gestodene and desogestrel in combination with 20-microg ethinyl estradiol induce similar changes in carbohydrate metabolism which are smaller than those described earlier for COCs containing higher estrogen doses or more androgenic progestins such as levonorgestrel. [less ▲]

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See detailLa reconnaissance et le financement de la laïcité organisée (I)
Sägesser, Caroline; Husson, Jean-François ULg

in Courrier Hebdomadaire du CRISP (2002), (1756), 3-43

This publication details the political process having led to the official recognition of the free thinkers organisations on a footing quite silmilar to religious denominations.

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See detailLa critique historique: méthode ou théorie de l'histoire? Libres propos en faveur du constructivisme
Havelange, Carl ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2002), 94-95-96

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See detailLes racines de l'arc-en-ciel
Jacquemain, Marc ULg

in Politique : Revue de Débats (2002), 26

L'article explore les fondements idéologiques qui ont présidé à la construction de la coalition libérale-socialiste-écologiste qui a dirigé la Belgique de 1999 à 2003. Si les écologistes se sont imposés ... [more ▼]

L'article explore les fondements idéologiques qui ont présidé à la construction de la coalition libérale-socialiste-écologiste qui a dirigé la Belgique de 1999 à 2003. Si les écologistes se sont imposés in extremis à la faveur de la crise de la dioxine en 1999, cela faisait un certain temps qu'un accord entre socialistes et libéraux pour mettre les partis chrétiens dans l'opposition était "dans l'air" : il s'agissait d'en finir avec un certain nombre de "verrous moraux" venus du monde catholique (notamment autour des valeurs familiales), qui apparaissaient de moins en moins en phase avec l'opinion publique. Cette mise à l'arrière-plan du clivage gauche/droite au profit du clivage laïque/clérical a sans doute bousculé plus durablement que prévu le paysage idéologique. [less ▲]

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See detailThe Disulphide Mapping, Folding and Characterisation of Recombinant Ber e 1, an Allergenic Protein, and SFA8, Two Sulphur-rich 2 S Plant Albumins
Alcocer, Marcos; Murtagh, G. J.; Bailey, Kevin et al

in Journal of Molecular Biology (2002), 324

We have cloned and expressed genes encoding the allergenic brazil nut 2 S albumin (Ber e 1) and the sunflower albumin 8 (SFA8) in the methylotrophic yeast Pichia pastoris. We show that both proteins were ... [more ▼]

We have cloned and expressed genes encoding the allergenic brazil nut 2 S albumin (Ber e 1) and the sunflower albumin 8 (SFA8) in the methylotrophic yeast Pichia pastoris. We show that both proteins were secreted at high levels and that the purified proteins were properly folded. We also showed that Ber e 1 is glycosylated during secretion and that the glycan does not interfere with the folding or immunoreactivity. The disulphide map of the Ber e 1 protein was experimentally established and is in agreement with the conserved disulphide structure of other members of the 2 S albumin family. A model three-dimensional structure of the allergen was generated. During the expression studies and through mutation we have also shown that alteration of the sequences around the Kex2 endoproteolytic processing site in the expressed fusion protein can compromise the secretion by targeting part of the protein for possible degradation. The secreted production of these properly folded sulphurrich plant albumins presents an opportunity to delineate the attributes that make an allergen and to facilitate the diagnosis and therapy of type I allergy. [less ▲]

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See detailAcute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
Hafezi-Moghadam, Ali; Simoncini, Tommaso; Yang, Zequan et al

in Nature Medicine (2002), 8(5), 473-9

Corticosteroids have been shown to exert beneficial effects in the treatment of acute myocardial infarction, but the precise mechanisms underlying their protective effects are unknown. Here we show that ... [more ▼]

Corticosteroids have been shown to exert beneficial effects in the treatment of acute myocardial infarction, but the precise mechanisms underlying their protective effects are unknown. Here we show that high-dose corticosteroids exert cardiovascular protection through a novel mechanism involving the rapid, non-transcriptional activation of endothelial nitric oxide synthase (eNOS). Binding of corticosteroids to the glucocorticoid receptor (GR) stimulated phosphatidylinositol 3-kinase and protein kinase Akt, leading to eNOS activation and nitric oxide dependent vasorelaxation. Acute administration of pharmacological concentrations of corticosteroids in mice led to decreased vascular inflammation and reduced myocardial infarct size following ischemia and reperfusion injury. These beneficial effects of corticosteroids were abolished by GR antagonists or eNOS inhibitors in wild-type mice and were completely absent in eNOS-deficient (Nos3(-/-)) mice. The rapid activation of eNOS by the non-nuclear actions of GR, therefore, represents an important cardiovascular protective effect of acute high-dose corticosteroid therapy. [less ▲]

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See detailLa reconnaissance et le financement de la laïcité (II)
Husson, Jean-François ULg; Sägesser, Caroline

in Courrier Hebdomadaire du CRISP (2002), (1760), 3-52

This paper details the administrative organisation and financial support for the various organisations and services from the Belgian free thinkers, after an official recognition on a footing quite similar ... [more ▼]

This paper details the administrative organisation and financial support for the various organisations and services from the Belgian free thinkers, after an official recognition on a footing quite similar to the one of religious denominations. [less ▲]

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See detailProblèmes, situations-problèmes en mathématique : un regard pluraliste.
Schneider, Marguerite ULg

in Mathématique et Pédagogie (2002), 137

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See detailGene transcript quantitation by real-time RT-PCR in cells selected by immunohistochemistry-laser capture microdissection.
Lindeman, Neal; Waltregny, David ULg; Signoretti, Sabina et al

in Diagnostic Molecular Pathology : The American Journal of Surgical Pathology, Part B (2002), 11(4), 187-92

Studying tissue-based gene expression in different cell populations often requires immunohistochemistry-guided microdissection. However, mRNA degradation occurs during long staining procedures. We ... [more ▼]

Studying tissue-based gene expression in different cell populations often requires immunohistochemistry-guided microdissection. However, mRNA degradation occurs during long staining procedures. We combined a novel rapid immunoperoxidase technique with laser capture microdissection (LCM) and real-time quantitative RT-PCR to compare p27 mRNA expression in prostatic basal/secretory cells. Eight frozen prostate sections were immunostained with antibody 34betaE12 (high-molecular-weight keratin). Secretory and basal cells were separately collected by LCM. p27 transcripts from each cell group were quantitated by real-time RT-PCR, with GAPDH as standard. Immunostaining took 22 minutes, with RNA extraction from approximately 40 dissected cells from each compartment initiated within 40 minutes. Qualitative RT-PCR gave a product of the expected size from each sample. Quantitative RT-PCR gave basal/secretory p27/GAPDH ratios of 0.99-16.24 (mean 5.53 +/- 0.643). Immunostaining for keratin 34betaE12 can be done on frozen sections in approximately 20 minutes, and mRNA from pure cell populations can be quantitated by RT-PCR. We used this technique to show that p27 transcript levels are greater in basal than in secretory prostate cells, suggesting, when combined with prior studies, that regulation of p27 occurs at the protein level in normal cells. This technique may have wide applicability to studies of gene expression in distinct cell populations in heterogeneous tissues. [less ▲]

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See detailLa science au service de l'apostolat. L'enseignement des Jésuites anglais à Liège aux XVIIe et XVIIIe siècles
Opsomer, Carmélia ULg

in Archives Internationales d'Histoire des Sciences (2002), 52(148), 212-226

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See detailRate coefficient determination in charge transfer reactions
Vaeck, Nathalie; Baloïtcha, Ezinvy; Desouter, Michèle ULg et al

in International Journal of Molecular Sciences (2002), 3

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See detailL'exclusion de la réassurance des règles européennes de conflits de juridictions en matière de contrats d'assurance
Boularbah, Hakim ULg

in Bulletin des Assurances = Tijdschrift voor Verzekeringen (2002)

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See detailA double-blind placebo-controlled study of ketoconazole + desonide gel combination in the treatment of facial seborrheic dermatitis.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(4), 344-7

BACKGROUND: The pathobiology of seborrheic dermatitis is rooted in a peculiar inflammatory reaction to Malassezia spp. Both topical corticosteroids and antifungals are routinely used with success, either ... [more ▼]

BACKGROUND: The pathobiology of seborrheic dermatitis is rooted in a peculiar inflammatory reaction to Malassezia spp. Both topical corticosteroids and antifungals are routinely used with success, either singly or in combination. OBJECTIVE: To assess the effect of a new combination therapy in this condition. METHODS: Eighteen patients with facial seborrheic dermatitis were treated in a pilot double-blind trial with an anhydrous gel containing the combination of 2% ketoconazole and 0.05% desonide (n = 9) or the unmedicated gel (n = 9). The products were applied once daily for 3 consecutive weeks. Disease severity was assessed at the start and weekly during treatment, as well as 2, 4 and 8 weeks after the end of treatment or at the time of recurrence. The overall clinical assessments were performed using a visual analogue scale. Objective measurements included squamometry X after harvesting the stratum corneum and the erythema index yielded by narrow-band reflectance spectrophotometry. Data were evaluated in an intent-to-treat analysis. RESULTS: The combination therapy yielded reductions in the overall clinical symptom severity of 49, 84 and 92% after 1, 2 and 3 weeks of treatment, respectively. The corresponding improvements with the placebo gel were significantly smaller (p < 0.01), reaching 23, 29 and 42% at successive 1-week intervals. At the end of the 3-week treatment, the clinical signs had completely subsided in 6/9 patients treated with the medicated gel and in only 1/9 patients using the placebo gel. Thus, the clinical response rate was significantly faster (p < 0.01) with the combination therapy than with the vehicle. Differences between the treatment groups using objective noninvasive assessments were also significantly (p < 0.01) in favor of the combination therapy. The squamometry X measurements showed 47, 67 and 74% improvements with the combination gel after 1, 2 and 3 weeks, respectively. The corresponding values with the placebo gel were 34, 46 and 53%, respectively. The erythema index was almost completely reduced to normal at week 2 of treatment in contrast with about 50% reduction with the unmedicated vehicle. None of the patients reported any side effects. CONCLUSION: The combination of ketoconazole with desonide in an anhydrous gel is well tolerated and proves to be significantly more effective than the vehicle for treating facial seborrheic dermatitis. The fast response to treatment and the limited additional improvement between weeks 2 and 3 of the treatment suggest that this combination product may be efficacious with once daily applications for 2 weeks. These data call for expanded studies comparing each single compound, the vehicle and the combination therapy. [less ▲]

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See detailL'entrée en vigueur du permis d'environnement et du permis unique
Pâques, Michel ULg

in Actualité législative en droit immobilier (2002)

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See detailAnalysis Of The C-Terminal Membrane Anchor Domains Of Hepatitis C Virus Glycoproteins E1 And E2: Toward A Topological Model
Charloteaux, Benoît ULg; Lins, Laurence ULg; Moereels, H. et al

in Journal of Virology (2002), 76(4), 1944-58

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen ... [more ▼]

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen where they remain. The 31 C-terminal residues of the E1 protein and the 29 C-terminal residues of the E2 protein are implicated in the ER retention. Moreover, the E1 and E2 C termini are implicated in E1-E2 heterodimerization. We studied the E1 and E2 C-terminal sequences of 25 HCV strains in silico using molecular modeling techniques. We conclude that both C-terminal domains should adopt a similar and peculiar configuration: one amphipathic alpha-helix followed by a pair of transmembrane beta-strands. Several three-dimensional (3-D) models were generated. After energy minimization, their ability to interact with membranes was studied using the molecular hydrophobicity potentials calculation and the IMPALA procedure. The latter simulates interactions with a membrane by a Monte Carlo minimization of energy. These methods suggest that the beta-hairpins could anchor the glycoproteins in the ER membrane at least transiently. Anchoring could be stabilized by the adsorption of the nearby amphipathic alpha-helices at the membrane surface. The 3-D models correlate with experimental results which indicate that the E1-E2 transmembrane domains are involved in the heterodimerization and have ER retention properties. [less ▲]

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See detailEvidence for a persistent and extensive greening trend in Eurasia inferred from satellite vegetation index data.
Bogaert, Jan ULg; Zhou, L; Tucker, C J et al

in Journal of Geophysical Research (2002), 107(D11),

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See detailOn-line fruit grading according to their external quality using machine vision
Leemans, Vincent ULg; Magein, Hugo ULg; Destain, Marie-France ULg

in Biosystems Engineering (2002), 83(4), 397-404

This paper presents apple grading into four classes according to European standards. Two varieties were tested: Golden Delicious and Jonagold. The image database included more than a 1000 images of fruits ... [more ▼]

This paper presents apple grading into four classes according to European standards. Two varieties were tested: Golden Delicious and Jonagold. The image database included more than a 1000 images of fruits (528 Golden Delicious, 642 Jonagold) belonging to the three acceptable categories-Extra, I and II-and the reject (each class represents, respectively, about 60, 10 and 20% of the sample size). The image grading was achieved in six steps: image acquisition; ground colour classification; defect segmentation; calyx and stem recognition; defects characterisation and finally the fruit classification into quality classes. The proposed method for apple external quality grading showed correct classification rates of 78 and 72%, for Golden Delicious and Jonagold apples, respectively. Taking into account that the healthy fruit were far better graded and considering that this class was under represented in the sample compared with the fruit population, the results of the proposed method (an error rate which drops to 5 and 10%, respectively) are compatible with the requirements of European standards. (C) 2002 Silsoe Research Institute. Published by Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPositron emission tomography in non-Hodgkin's lymphoma (NHL): relationship between tracer uptake and pathological findings, including preliminary experience in the staging of low-grade NHL.
Jerusalem, Guy ULg; Beguin, Yves ULg

in Clinical Lymphoma (2002), 3(1), 56-61

Advances in imaging techniques have allowed more precise staging and better evaluation of the effect of new treatment modalities. The limitations of conventional morphologic imaging techniques are well ... [more ▼]

Advances in imaging techniques have allowed more precise staging and better evaluation of the effect of new treatment modalities. The limitations of conventional morphologic imaging techniques are well known. Positron emission tomography (PET) using fluorine-18-labeled fluorodeoxyglucose is now routinely used for initial staging and re-evaluation during or after treatment of Hodgkin's disease and aggressive non-Hodgkin's lymphoma (NHL), but not in low-grade NHL. In the first part of this review, the relationship between glucose metabolism as measured by PET, pathological findings including histological grade and proliferative activity, and prognosis are analyzed. In the second part, the potential role of PET in the staging and follow-up of low-grade NHL is discussed. Published data indicate that PET may contribute to the management of low-grade follicular NHL. [less ▲]

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See detailFactor XIII a-positive dermal dendrocytes and shear wave propagation in human skin.
Hermanns-Lê, Trinh ULg; Uhoda, I.; Pierard, Claudine ULg et al

in European Journal of Clinical Investigation (2002), 32(11), 847-51

BACKGROUND: The in vivo interdependence between the phenotypic characteristics of dermal cells and the strain imposed on the tissue has not been studied thoroughly in humans. In particular the mechanical ... [more ▼]

BACKGROUND: The in vivo interdependence between the phenotypic characteristics of dermal cells and the strain imposed on the tissue has not been studied thoroughly in humans. In particular the mechanical force modulation of Factor XIII a expression in dermal dendrocytes (DD) remains unknown. MATERIALS AND METHODS: The present study compares the numerical density of Factor XIII a-positive DD and the in vivo shear wave velocity in the skin. The investigation was performed in 20 men of normal weight and 20 obese men before and after entering a slimming process. RESULTS: Excess cutaneous fat places the skin under increased intrinsic tension. The resonance running time measurement (RRTM) and the DD density were significantly reduced in overweight individuals. After a short-term but intense slimming process, the same individuals showed a trend to normalization of these two parameters without, however, reaching significance. Pooling all data yielded a significant logarithmic correlation between RRTM values and densities in Factor XIII a-positive DD. CONCLUSION: Factor XIII a expression in human DD may be partially regulated by the intrinsic resting tensions in the skin. [less ▲]

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See detailFatty Acid Hydroperoxides Biotransformation By Potato Tuber Cell-Free Extracts
Fauconnier, Marie-Laure ULg; Delcarte, J.; Jaziri, M. et al

in Journal of Plant Physiology (2002), 159(10),

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See detailProteus syndrome of the hand.
Fraiture, Anne Laure; Ihou, E David; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(4), 318-20

Proteus syndrome exhibits an expanded phenotype. We report a case with restricted macrodactyly and cerebriform hypertrophy of one palm. The differential diagnosis with macrodactyly and other hamartomatous ... [more ▼]

Proteus syndrome exhibits an expanded phenotype. We report a case with restricted macrodactyly and cerebriform hypertrophy of one palm. The differential diagnosis with macrodactyly and other hamartomatous overgrowth syndromes is discussed. [less ▲]

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See detailLes mutualités professionnelles, un axe majeur de la politique sociale patronale pendant l'Entre-deux-guerres en Belgique ?»,
Geerkens, Eric ULg

in Revue Belge de Philologie et d'Histoire (2002), 80(4), 1275-1349

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See detailRadiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.
Egger, J-F; Coindre, J-M; Benhattar, J et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2002), 15(9), 998-1004

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant ... [more ▼]

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004 [less ▲]

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See detailLa réalité morale du sociologue : le cognitivisme de Raymond Boudon
Jacquemain, Marc ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2002), 94-95-96

Raymond Boudon defends that the social actor holds overall rational beliefs : we have "good reasons" for most of our beliefs. But he also defends the idea that those "good reasons" can lead to "moral ... [more ▼]

Raymond Boudon defends that the social actor holds overall rational beliefs : we have "good reasons" for most of our beliefs. But he also defends the idea that those "good reasons" can lead to "moral truths". How then can he avoid pure platonism (the idea that "values" exist objectively in a world of their own) ? When confronting to to the task of defending through concrete examples how we can differentiate "good reasons" from bad ones, he says that good reasons are widely shared. But then the idea of objectivity of values dissolves in a loose theory of opinion, that's to say "doxa", which is the very contrary of platonic ideas. So the intent to point to "objective" values seems to lead either to pure dogmatism or to pure relativism. [less ▲]

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See detailThe beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study.
Fumal, I.; Braham, C.; Paquet, Philippe ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204 Suppl 1

BACKGROUND: Some of the views contrasting the beneficial and toxic effects of antimicrobials upon wound healing remain controversial. OBJECTIVE: To assess the clinical relevance of histological findings ... [more ▼]

BACKGROUND: Some of the views contrasting the beneficial and toxic effects of antimicrobials upon wound healing remain controversial. OBJECTIVE: To assess the clinical relevance of histological findings following antimicrobial applications on chronic leg ulcers. METHOD: The present study was performed in three parallel groups of 17 patients suffering from at least 2 similar chronic leg ulcers. Clinical planimetric assessments were performed before and after 3 and 6 weeks of treatment using hydrocolloid dressings. In addition, 1 ulcer in each patient received applications of povidone-iodine (PVP-I), silver sulfadiazine or chlorhexidine digluconate. Histological examinations were made at inclusion and after the 6-week therapy. Time to healing was also recorded. RESULTS: At entry in the study, fibroblasts, macrophages, neutrophils and vessels were abundant in the ulcers. In addition, focal necrotizing vasculitis was related to the microbiological load. Compared to the control lesions, both the healing rate and time to healing of the leg ulcers showed a modest improvement at the sites receiving silver sulfadiazine (2-7%) or chlorhexidine digluconate (-1 to 5%). By contrast, PVP-I increased significantly the healing rate (4-18%, p < 0.01), and time to healing was reduced by 2-9 weeks (p < 0.01). The 3 antimicrobials decreased the bacterial density, and the vascular margination and migration of inflammatory cells, thus abating the vasculitic changes. PVP-I applications did not alter the microvessels and did not significantly reduce the density in dendrocytes and fibroblasts. By contrast, both silver sulfadiazine and chorhexidine digluconate appeared to alter the superficial microsvasculature including the dendrocyte population. CONCLUSION: Although topical antimicrobials may apparently achieve almost similar activity on the bacterial load inside chronic leg ulcers, the toxicity upon host cells was different among these agents. PVP-I appeared to be an efficient compound in these respects exhibiting a positive and relevant clinical effect. [less ▲]

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See detailModélisation de l’impact de mollusques filtreurs sur le phytoplancton de la Moselle.
Descy, Jean-Pierre; Everbecq, Etienne ULg; Gosselain, Véronique ULg et al

in Tribune de l'Eau (La) (2002), 55-56(n° 619-620), 130-138

Le modèle POTAMON (Everbecq & al., 2001) a été utilisé pour simuler l'effet de mollusques bivalves (principalement Dreissena polymorpha) sur le phytoplancton et le zooplancton d'une rivière de plaine, la ... [more ▼]

Le modèle POTAMON (Everbecq & al., 2001) a été utilisé pour simuler l'effet de mollusques bivalves (principalement Dreissena polymorpha) sur le phytoplancton et le zooplancton d'une rivière de plaine, la Moselle. Les simulations suggèrent un impact significatif des mollusques filtreurs sur le phytoplancton, en particulier en été. Les simulations ont également permis d'établir un bilan carbone de la rivière et d'expliquer les déficits en oxygène observés dans la Moselle. [less ▲]

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See detailNeoliberaal literatuuronderzoek. Thomas Vaessens over zijn methode, lecturen en stijl
Spinoy, Erik ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2002), 118(3),

This article is a reaction to Thomans Vaessens defence of his book Circus Dubio & Schroom.

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See detailBlanche-Neige était-elle transsexuelle ?
Michel, Aude; Mormont, Christian ULg

in Encéphale (L') (2002), 28(1), 59-64

The Rorschach Ink Blot test is considered to be an essential analytical instrument when studying the personalities of individuals presenting gender identity disorders, in particular, in the context of a ... [more ▼]

The Rorschach Ink Blot test is considered to be an essential analytical instrument when studying the personalities of individuals presenting gender identity disorders, in particular, in the context of a sex change request. Nevertheless, there exist less than 20 studies of transsexualism utilising the Rorschach since the creation of this diagnostic category in 1953. This research has mostly concerned itself with relations between psychopathology and transsexualism. Practically non-existent are studies investigating the psychological conditions that permit, shape or induce sex change requests in individuals. Transsexuals request the removal of their genitals through mutilation surgery, which can be seen as subjects literally crying out to be castrated. This request is all the more surprising given that castration, in psychoanalytic terms, is considered to be the most severe punishment that an individual (woman or man) can be threatened with. Therefore, we asked ourselves which psychic conditions could motivate such as request. Based on any earlier study where answers (some explicit, others symbolic) given by sex-change applicants tested on the Rorschach were analysed, results seemed to suggest a counter-phobic attitude underlying sex-reassignment requests (28). According to these hypotheses, the fear of castration (banal as such) can only be overcome through the active search for castration itself. In opting for castration, the transsexual puts an end to the states of anxious waiting that are dominated by feelings of the incertitude and unpredictability of an eventual castration. Once obtained, the threat it constituted disappears, and with it so does the fear. Thus, by taking this active and voluntary step, the subject is no longer exposed to an imminent danger in a passive manner. This in itself creates a great feeling of relief, if not of actual pleasure in the subject (28). In this article, we postulated in a purely speculative manner, the existence of one or several modalities in the transsexual dynamics. Nevertheless, one can ask oneself about the possibility of a request based on a desire rather than on a defense, or even on the existence of a defensive process diametrically opposed to the counter-phobic attitude and which, instead of actively provoking the dreaded reality, would privilege its avoidance and the search of passivity. This latter hypothesis has the advantage of being rather easy to explore with the Rorschach because, according to Exner, the predominance of passive compared to active human movement responses (which he terms the Snow White Syndrome) indicates the propensity to escape into passive fantasies and the tendency to avoid the initiative for behaviour or decision-making, if other people can do it in the subject's place (12). Our results largely confirmed the hypothesis of the existence of an opposite mechanism, as a third of subjects (n = 26) presented Snow White Syndrome. According to Exner, these transsexuals are typically characterized by hiding into a world of make believe, avoiding all responsibility, as well as any decision-making. This passivity in our Snow White Syndrome group was all the more remarkable in that, on the whole, it infiltrated into all the movement responses and seemed to define a rigid style of thinking and mental elaboration, in addition to a suggestive content of passivity. However, this condition cannot be associated with a general lack of dynamism or energy. In fact, the treatment of information, which provides data concerning the motivation to treat a stimulus field of the stimulus--whether this concerns the capture (L) of the stimulus or the elaboration (DQ+) of the response--displayed a sufficient amount of motivation. Furthermore, internal resources (EA) were considerable and were brought into play whenever it was necessary to adopt a behaviour or make a decision. Furthermore, based on these Rorschach findings, we note that in transsexuals with Snow White Syndrome, there is a stereotyped tendency to shy away from difficulties by seeking refuge in realistic representations (but that lack in variety), which could be materialized by actions, but where the initiative is delegated to others. These transsexuals appear to shy away from the difficulties of life by seeking refuge into a world of fantasy, which they fill with the representations borrowed from reality (rather than fantasy) and consequently that are liable to be transposed, if necessary, back into reality. Therefore, one can better understand why they shun away from the deceiving reality that their physical sex represents, into the satisfying dream where they possess the genitals of the opposite sex, that is, a perfectly real organ, no longer the result of the subject's fantasy world. [less ▲]

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See detailPrésentation. Du fantastique réel au réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 7-9

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See detailComment je traite ... la paralysie faciale par anastomose hypoglosso-faciale.
Courtmans, I; Born, J D; CARLIER, Alain ULg et al

in Revue Médicale de Liège (2002), 57(1), 3-6

Thirteen patients underwent a hypoglosso- or a spino-facial nerve anastomosis between 1990 and 1996. Facial palsy was the result of surgery in 12 cases and of radiosurgery in 1 case. The mean interval ... [more ▼]

Thirteen patients underwent a hypoglosso- or a spino-facial nerve anastomosis between 1990 and 1996. Facial palsy was the result of surgery in 12 cases and of radiosurgery in 1 case. The mean interval between facial palsy and anastomosis was 12 months. Facial nerve function is determined on the basis of clinical examination according to the classification of House-Brackmann and our own evaluation. According to House, 10 patients are classified grade III and 3 grade IV. Our evaluation defines in 10 grade III, 7 good results and 3 fair results. As far as the good results are concerned, the mean interval between palsy and anastomosis is short (< 3 months). The permanent eating and swallowing dysfunctions are consecutive to multiple cranial nerve deficits. The post-paralysis hemifacial spasm is facilitated by prolongated electric stimulations. [less ▲]

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See detailIs HIF-1alpha a pro- or an anti-apoptotic protein?
Piret, Jean-Pascal; Mottet, Denis ULg; Raes, Martine et al

in Biochemical Pharmacology (2002), 64(5-6), 889-92

Hypoxia-inducible factor-1 (HIF-1) is the major transcription factor specifically activated by hypoxia. It induces the expression of different genes whose products play an adaptive role for hypoxic cells ... [more ▼]

Hypoxia-inducible factor-1 (HIF-1) is the major transcription factor specifically activated by hypoxia. It induces the expression of different genes whose products play an adaptive role for hypoxic cells and tissues. Besides these protective responses, HIF-1 and/or hypoxia have also been shown to be either anti-apoptotic or pro-apoptotic, according to the cell type and experimental conditions. More severe or prolonged hypoxia rather induces apoptosis that is, at least in part, initiated by the direct association of HIF-1alpha and p53 and p53-induced gene expression. On the other hand, HIF-1alpha dimerized with ARNT, as an active transcription factor, can protect cells from apoptosis induced by several conditions. This review is aimed to describe the different mechanisms that account for these opposite effects of HIF-1alpha. [less ▲]

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See detailHepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients.
Paquot, Nicolas ULg; Scheen, André ULg; Dirlewanger, Mirjam et al

in Obesity Research (2002), 10(3), 129-34

OBJECTIVE: Obese non-diabetic patients are characterized by an extra-hepatic insulin resistance. Whether obese patients also have decreased hepatic insulin sensitivity remains controversial. RESEARCH ... [more ▼]

OBJECTIVE: Obese non-diabetic patients are characterized by an extra-hepatic insulin resistance. Whether obese patients also have decreased hepatic insulin sensitivity remains controversial. RESEARCH METHODS AND PROCEDURES: To estimate their hepatic insulin sensitivity, we measured the rate of exogenous insulin infusion required to maintain mildly elevated glycemia in obese patients with type 2 diabetes, obese non-diabetic patients, and lean control subjects during constant infusions of somatostatin and physiological low-glucagon replacement infusions. To account for differences in insulin concentrations among the three groups of subjects, an additional protocol was also performed in healthy lean subjects with higher insulin infusion rates and exogenous dextrose infusion. RESULTS: The insulin infusion rate required to maintain glycemia at 8.5 mM was increased 4-fold in obese patients with type 2 diabetes and 1.5-fold in obese non-diabetic patients. The net endogenous glucose production (measured with 6,6-(2)H(2)-glucose) and total glucose output (measured with 2-(2)H(1)-glucose) were approximately 30% lower in the patients than in the lean subjects. Net endogenous glucose production and total glucose output were both markedly increased in both groups of obese patients compared with lean control subjects during hyperinsulinemia. DISCUSSION: Our data indicate that both obese non-diabetic and obese type 2 diabetic patients have a blunted suppressive action of insulin on glucose production, indicating hepatic and renal insulin resistance. [less ▲]

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See detailCa2+/calmodulin dependent protein kinase regulates GABA activated Cl- current in cockroach dorsal unpaired median neurons
Alix, Philippe ULg; Grolleau, F; Hue, B

in Journal of Neurophysiology (2002), 87

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in ... [more ▼]

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in symmetrical chloride solutions. All DUM neurons voltage-clamped at -50 mV displayed inward currents (I(GABA)) when 10(-4) M of GABA was applied by pneumatic pressure-ejection pulses. The semi-logarithmic curve of I(GABA) amplitude versus the ejection time yielded a Hill coefficient of 4.0. I(GABA) was chloride (Cl-) because the reversal potential given by the current-voltage (I-V) curve varied according to the value predicted by the Nernst equation for Cl- dependence. In addition, I(GABA) was almost completely blocked by bath application of the chloride channel blockers picrotoxin (PTX) or 3,3-bis(trifluoromethyl)bicyclo-[2,2,1]heptane-2,2-diacarbonitrile (BIDN). The I-V curve for I(GABA) displayed a unexpected biphasic aspect and was best fitted by two linear regressions giving two slope conductances of 35.6 +/- 2.1 and 80.9 +/- 4.1 nS for potentials ranging from 0 to -30 and -30 to -70 mV, respectively. At -50 mV, the current amplitude was decreased by cadmium chloride (CdCl2, 10(-3) M) and calcium-free solution. The semi-logarithmic curve for CdCl2-resistant I(GABA) gave a Hill coefficient of 2.4. Hyperpolarizing voltage step from -50 to -80 mV was known to increase calcium influx through calcium-resting channels. According to this protocol, a significant increase of I(GABA) amplitude was observed. However, this effect was never obtained when the same protocol was applied on cell body pretreated with CdCl2. When the calmodulin blocker N-(6-aminohexyl)-5-chloro-1-naphtalene-sulfonamide or the calcium-calmodulin-dependent protein kinase blocker 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) was added in the pipette solution, I(GABA) amplitude was decreased. Pressure ejection application of the cis-4-aminocrotonic acid (CACA) on DUM neuron cell body held at -50 mV, evoked a Cl- inward current which was insensitive to CdCl2. The Hill plot yielded a Hill coefficient of 2.3, and the I-V curve was always linear in the negative potential range with a slope conductance of 32.4 +/- 1.1 nS. These results, similar to those obtained with GABA in the presence of CdCl2 and KN-62, indicated that CACA activated one subtype of GABA receptor. Our study demonstrated that at least two distinct subtypes of Cl--dependent GABA receptors were expressed in DUM neurons, one of which is regulated by an intracellular Ca2+-dependent mechanism via a calcium-dependent protein kinase. The consequences of the modulatory action of Ca2+ in GABA receptors function and their sensitivity to insecticide are discussed. [less ▲]

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See detailTNF-alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB
Relic, Biserka ULg; Bentires-Alj, Mohamed; Ribbens, Clio ULg et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2002), 82(12), 1661-1672

TNF-alpha plays a key role in rheumatoid arthritis, but its effect on chondrocyte survival is still conflicting. In the present study, we tested how TNF-alpha influences chondrocyte survival in response ... [more ▼]

TNF-alpha plays a key role in rheumatoid arthritis, but its effect on chondrocyte survival is still conflicting. In the present study, we tested how TNF-alpha influences chondrocyte survival in response to nitric oxide (NO)-related apoptotic signals, which are abundant during rheumatoid arthritis. Human primary articular chondrocytes or cartilage explants were pretreated with TNF-alpha for 24 hours and then treated with the proapoptotic NO donor sodium-nitro-prusside (SNP) for an additional 24 hours. TNF-alpha pretreatment markedly protected chondrocytes from SNP-induced cell death. Preincubation of chondrocytes with TNF-alpha inhibited both SNP-induced high-molecular weight DNA fragmentation and annexin V-FITC binding. Of interest, TNF-alpha induced persistent nuclear factor-kappaB (NF-kappaB)-DNA binding activity even in the presence of SNP, mirroring apoptosis protection effects. Both the TNF-alpha antiapoptotic effect and NF-kappaB-DNA binding activity were significantly inhibited by NF-kappaB inhibitors, Bay 11-7085, MG-132, and adenovirus-expressing mutated IkappaB-alpha. Phosphatidylinositol-3 kinase inhibitor LY 294002 also markedly inhibited the antiapoptotic effect of TNF-alpha. In primary chondrocytes, TNF-alpha induced expression of the antiapoptotic protein Cox-2, which persisted in the presence of SNP, and a specific Cox-2 inhibitor significantly blocked the TNF-alpha protective effect. We therefore conclude that TNF-alpha-mediated protection of chondrocytes from NO-induced apoptosis acts through NF-kappaB and requires Cox-2 activity. [less ▲]

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See detailComment j'explore.... Une sclérodermie cutanée d'une manière non invasive.
Fraiture, A. L.; Henry, Frédérique ULg; Goffin, Véronique ULg et al

in Revue Médicale de Liège (2002), 57(3), 179-82

There exists several clinical types of scleroderma. Most of them show cutaneous manifestations. Skin involvement may be isolated (morphea) or be part of a multi-organ systemic disease. Objective non ... [more ▼]

There exists several clinical types of scleroderma. Most of them show cutaneous manifestations. Skin involvement may be isolated (morphea) or be part of a multi-organ systemic disease. Objective non-invasive functional methods are useful in order to better assess the severity and evolution of the disease and the effects of treatments. Measurements of the thickness and mechanical properties of the skin as well as the visualization of the cutaneous blood flow prove to be informative. [less ▲]

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See detailPregnancy and inflammatory bowel disease
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (2002), 65(4, Oct-Dec), 230-232

Overall, around 25% of women with inflammatory bowel disease will conceive during their disease. Most of the women with inflammatory bowel disease will have a normal pregnancy and healthy children ... [more ▼]

Overall, around 25% of women with inflammatory bowel disease will conceive during their disease. Most of the women with inflammatory bowel disease will have a normal pregnancy and healthy children. However, specific problems may arise related to these pregnancies. This paper reviews what is known on fertility, risk of disease transmission, effect of the disease on the pregnancy and the reverse, delivery, medical follow up and treatment as well as breastfeeding in the setting of inflammatory bowel disease. [less ▲]

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See detailWilliam S. Burroughs: Du cut-up au simulacre
Claisse, Frédéric ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2002), (94-95-96), 151-174

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See detailSingle step synthesis of metal catalysts supported on porous carbon with controlled texture
Job, Nathalie ULg; Ferauche, fabrice; Pirard, René ULg et al

in Studies in Surface Science and Catalysis (2002), 143

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See detailLa forêt et la protection du sol dans le cadre d'aménagement forestiers intégrés
Huart, O.; Adam, V.; Quevy, B. et al

in Fiche technique (2002), (14),

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See detailAllergic reactions to decorative skin paintings
Nikkels, Arjen ULg; Henry, Frédérique ULg; Pierard, Gérald ULg

in Allergy Review series (2002), 3

Three children presented with contact sensitization to decorative skin paintings applied during their summer holidays. Patch testing revealed severe contact hypersensitivity to p-phenylenediamine (PPD) in ... [more ▼]

Three children presented with contact sensitization to decorative skin paintings applied during their summer holidays. Patch testing revealed severe contact hypersensitivity to p-phenylenediamine (PPD) in all patients. The eruptions healed following spontaneous elimination of the dyes and application of topical corticosteroids, but left postinflammatory depigmentation. PPD was the main allergen identified in allergic reactions to decorative skin paintings. [less ▲]

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See detailStudy of the early abortion in reciprocal crosses between Phaseolus vulgaris L. and Phaseolus polyanthus Greenm
Geerts, P.; Toussaint, André ULg; Mergeai, Guy ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(2), 109-119

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See detailLong-pulsed ruby laser-assisted hair removal in male-to-female transsexuals.
Paquet, Philippe ULg; Fumal, I.; Pierard, Claudine ULg et al

in Journal of Cosmetic Dermatology (2002), 1(1), 8-12

BACKGROUND: Unwanted male-pattern pilosity is a heavy psychological burden and can cause distress for male-to-female transsexuals. Orchidectomy and oestrogen supplementation combined with antiandrogens ... [more ▼]

BACKGROUND: Unwanted male-pattern pilosity is a heavy psychological burden and can cause distress for male-to-female transsexuals. Orchidectomy and oestrogen supplementation combined with antiandrogens fail to make hair disappear. AIMS: To study the effect of long-pulsed ruby laser treatment. RESULTS: Hair density was successfully abated on the beard and chest of three male-to-female transsexuals. A lingering effect over 6 months with a 50-90% hair density reduction was obtained. CONCLUSION: Photothermolysis using the long-pulsed ruby laser is a promising, well-tolerated method of hair removal in male-to-female transsexuals under oestrogen supplementation and antiandrogens. [less ▲]

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See detailPositional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
Grisart, B.; Coppieters, Wouter ULg; Farnir, Frédéric ULg et al

in Genome Research (2002), 12(2), 222-231

We recently mapped a quantitative trait locus (QTL) with a major effect on milk composition-particularly fat content-to the centromeric end of bovine chromosome 14. We subsequently exploited linkage ... [more ▼]

We recently mapped a quantitative trait locus (QTL) with a major effect on milk composition-particularly fat content-to the centromeric end of bovine chromosome 14. We subsequently exploited linkage disequilibrium to refine the map position of this QTL to a 3-cM chromosome interval bounded by microsatellite markers BULGE13 and BULGE09. We herein report the positional candidate cloning of this QTL, involving (I) the construction of a BAC contig spanning the corresponding marker interval, (2) the demonstration that a very strong candidate gene, acylCoA:diacylglycerol acyltransferase (DGATf), maps to that contig, and (3) the identification of a nonconservative K232A substitution in the DGAT1 gene with a major effect on milk fat content and other milk characteristics. [less ▲]

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See detailAmélioration des ovins dans l'Ouémé et le Plateau en République du Bénin. Enjeux des croisements des ovins Djallonké avec les moutons du Sahel
Gbangboche, A. B.; Abiola, F. A.; Laporte, J.-P. et al

in Tropicultura (2002), 20(2), 70-75

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See detailBudesonide in Collagenous colitis: A Double-Blind Placebo-Controlled Trial With Histologic Follow-Up
Baert, Filip; Schmit, Alain; D'Haens, Geert et al

in Gastroenterology (2002), 122

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See detailStaging of regional nodes in AJCC stage I and II melanoma: 18FDG PET imaging versus sentinel node detection.
Belhocine, Tarik; Pierard, Gérald ULg; De Labrassinne, Michel et al

in Oncologist (2002), 7(4), 271-8

PRIMARY PURPOSE: The staging of regional nodes by means of sentinel node detection has been shown to accurately detect subclinical nodal metastases from cutaneous melanoma. On the other hand, the ... [more ▼]

PRIMARY PURPOSE: The staging of regional nodes by means of sentinel node detection has been shown to accurately detect subclinical nodal metastases from cutaneous melanoma. On the other hand, the oncological applications of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18FDG PET) are, nowadays, firmly established. However, the sensitivity of such metabolic imaging for staging the regional nodes in primary melanoma remains debatable. We prospectively assessed the actual value of PET for detecting sentinel node metastases in 21 consecutive patients presenting with early-stage melanoma. MATERIALS AND METHODS: Twenty-one melanoma patients scheduled for lymphatic mapping and sentinel lymphadenectomy underwent fully corrected whole-body PET using 18FDG. In all cases, the disease was initially classified as either stage I or II, from the latest version of the American Joint Committee on Cancer staging system. The sentinel node detection was systematically performed within the week following the PET scan. Serial sections of the sentinel nodes were analyzed by both conventional pathology and immunohistochemical staining. Metastatic sentinel nodes were also assessed for the size of tumor deposits and the degree of nodal involvement (focal, partial, or massive). The median follow-up time was 12 months. RESULTS: Six of the 21 patients (28.5%) had an involved sentinel node. PET was positive in only one case with a sentinel node >1 cm. In the five other cases, the sentinel nodes missed by PET were <1 cm with focal and/or partial involvements. One patient, free of regional nodal metastases in both sentinel node detection and PET imaging, had, however, a same-basin recurrence 3 months later. In another case, PET had one false positive result. Overall, the sentinel detection of subclinical nodal metastases had a sensitivity of 86%. PET detected only 14% of sentinel node metastases. CONCLUSIONS: Sentinel node detection remains the procedure of choice for detecting subclinical lymph node involvement from primary cutaneous melanoma. Owing to its limited spatial resolution, PET appears insufficiently sensitive to identify microscopic nodal metastases. As a practical consequence, metabolic imaging is not recommended as a first-line imaging strategy for staging regional lymph nodes in patients with stage I or II melanoma. [less ▲]

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See detailLe métabolisme du fer
Beguin, Yves ULg

in Hématologie (2002), 8

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See detailAn efficient time discretization procedure for finite element-electronic circuit equation coupling
Dular, Patrick ULg; Kuo-Peng, P.

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2002), 21(2), 274-285

An efficient and robust time discretization procedure of theta type is proposed in the frame of the finite element-circuit equation coupling for electronic circuits with switches, i.e. the use of diodes ... [more ▼]

An efficient and robust time discretization procedure of theta type is proposed in the frame of the finite element-circuit equation coupling for electronic circuits with switches, i.e. the use of diodes, thyristors and transistors. This procedure enables the use of the Crank-Nicolson scheme whatever the circuit and its working conditions by eliminating the undesirable oscillations of the solution peculiar to this scheme. It is based on the accurate determination of the switching instants and on a local modification of the theta parameter. [less ▲]

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See detailEvaluation par ultrasonographie en temps réel de la teneur en gras intramusculaire du porc Piétrain
Youssao, A. K. I.; Verleyen, Vincent ULg; Michaux, Charles ULg et al

in Annales de Médecine Vétérinaire (2002), 146(4), 249-255

Real-time ultrasound data collection, consisting specifically of longissimus thoracis muscle echogenicity, was carried out on 80 Pietrain pigs (42 gilts and 34 barrows) using the Pie Medical scanner 200 ... [more ▼]

Real-time ultrasound data collection, consisting specifically of longissimus thoracis muscle echogenicity, was carried out on 80 Pietrain pigs (42 gilts and 34 barrows) using the Pie Medical scanner 200 equipped with an ASP-18 probe and 3.5 MHz to predict intramuscular fat. Two ribs thickness (12th and 13th ribs) was excised from the longissimus thoracis muscle for subsequent ether extract value (EE) determination. The percentage of white pixels in the ultrasound image were related to EE percentage. The EE percentages were 1.44, 1.37 and 1.15 % respectively for the homozygous stress-negative Pietrain (CC), heterozygous stress-negative Pietrain (CT) and homozygous stress-positive Pietrain (TT) individuals. The percentage of white pixels in the longissimus thoracis images were 9.98, 8.75 and 7.79 % respectively for CC, CT and TT genotypes. The barrows had an higher intramuscular fat and white pixel percentage than the gilts. The determination coefficient (R 2) of the EE prediction model originating from the white pixels percentage was 0.35 with a root mean squared error of 0.26 %. These performance could be potentially improved using the calibration phantom of the ASP-18 probe, before taking images. [less ▲]

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See detailComment j'explore ... le syndrome d'Alport par la biopsie cutanée. Quand la peau parle pour le rein.
Delanaye, Pierre ULg; Nikkels, Arjen ULg; Martalo, O. et al

in Revue Médicale de Liège (2002), 57(10), 670-1

Alport's syndrome is a severe hereditary renal disease. Type IV collagen is abnormal in its molecular composition both in the kidneys and the skin. Immunohistochemistry performed on a conventional skin ... [more ▼]

Alport's syndrome is a severe hereditary renal disease. Type IV collagen is abnormal in its molecular composition both in the kidneys and the skin. Immunohistochemistry performed on a conventional skin biopsy allows to prove the diagnosis in the affected subjects and in healthy women exhibiting the mutation on a single X chromosome. [less ▲]

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See detailLes conséquences des abus sexuels: le poids des préjugés ou "Il faut brûler Galilée"
Mormont, Christian ULg

in Forensic (2002), 10

Tous les mineurs exposés à des comportements sexuels inappropriés ne présentent pas des séquelles significatives à l'âge adulte. Le fait d'avoir vécu ces expériences sexuelles de façon négative ou de ... [more ▼]

Tous les mineurs exposés à des comportements sexuels inappropriés ne présentent pas des séquelles significatives à l'âge adulte. Le fait d'avoir vécu ces expériences sexuelles de façon négative ou de façon neutre ou positive semble avoir beaucoup d'importance et devrait être pris en compte dans les recherches [less ▲]

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See detailImportance of pedogenic factors in the spatial distribution of some soils properties in the Belgian Loess Belt: II. Some loess-substratum contacts
Colinet, Gilles ULg; Lacroix, Daniel ULg; Bock, Laurent ULg

in Aardkundige Mededelingen (2002), 12

The geochemical influence of parent material on soil content in some metallic trace elements (MTE) is studied in the Belgian loess belt. The first results show straight sharp Transitions between loess and ... [more ▼]

The geochemical influence of parent material on soil content in some metallic trace elements (MTE) is studied in the Belgian loess belt. The first results show straight sharp Transitions between loess and substratum. This leads to the conclusion that most soils should have the same range of natural values of MTE content. [less ▲]

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See detailPhytoremediation of polyaromatic hydrocarbons, anilines and phenols
Harvey, P. J.; Campanella, Bruno ULg; Castro, P. et al

in Environmental Science and Pollution Research (2002), 9

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See detailObservations sur l'adage: Periculum est emptoris
Gerkens, Jean-François ULg

in Cahiers du Centre de Recherches en Histoire du Droit et des Institutions (2002), (17), 117-133

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See detailWhite-sided dolphin metallothioneins: purification, characterisation and potential role
Das, Krishna ULg; Jacob, Valérie; Bouquegneau, Jean-Marie ULg

in Comparative Biochemistry & Physiology Part C : Toxicology & Pharmacology (2002), 131(3),

Metallothioneins (MTs) were characterised in the kidneys of a white-sided dolphin Lagenorhynchus acutus stranded along the Belgian coast, displaying high levels of cadmium (Cd) and mercury (Hg) in liver ... [more ▼]

Metallothioneins (MTs) were characterised in the kidneys of a white-sided dolphin Lagenorhynchus acutus stranded along the Belgian coast, displaying high levels of cadmium (Cd) and mercury (Hg) in liver and kidney. The protein has two isoforms: MT-1 and MT-2. MT-1 binds Cu, Zn, Hg and Cd, while MT-2 only binds Zn, Hg and Cd. This suggests different metabolic functions for the two isoforms: MT-1 is mainly involved in Cu homeostasis; MT-2, which was fourfold more abundant than MT-1, detoxifies most of the accumulated cadmium. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailLe roman poétique en 1929. Nord, entre fantastique réel et réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 31-40

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See detailChoice of probing site for estimation of carcass lean percentage in Piétrain pig using the real-time ultrasound
Youssao, A. K. L.; Verleyen, Vincent ULg; Michaux, Charles ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(4), 195-200

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See detailPrise en compte du bien-être des animaux dans l’aménagement des porcheries : les aspects réglementaires
Nicks, Baudouin ULg; Laitat, Martine ULg; Vandenheede, Marc ULg

in Annales de Médecine Vétérinaire (2002), 146(1), 39-42

A new directive laying down standards for the protection of pigs was published in the Official Journal of the European Communities (directive 2001/88/CE ; OJC 1 Decembre 2001). This directive is amending ... [more ▼]

A new directive laying down standards for the protection of pigs was published in the Official Journal of the European Communities (directive 2001/88/CE ; OJC 1 Decembre 2001). This directive is amending directive 91/630/CEE entered into force in Belgium in 1994. The three main topics refer to : the characteristics of the flooring surfaces, pregnant sows housing and the feeding systems. This paper details and discusses these topics and other points involving modifications of pig housing and management. [less ▲]

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See detailPistes de réflexion pour développer, à l’école, les compétences de tous les élèves
Beckers, Jacqueline ULg

in L’École valdôtaine (2002), 55

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See detailFurther evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Pitchot, William ULg et al

in Personality & Individual Differences (2002), 33(6), 967-977

In the biosocial model of Cloninger, three major personality dimensions, novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are dependent on central monoaminergic systems, respectively ... [more ▼]

In the biosocial model of Cloninger, three major personality dimensions, novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are dependent on central monoaminergic systems, respectively dopaminergic, serotonergic, and noradrenergic. This study investigated the relationships between these major personality dimensions and growth hormone (GH) responses to both apomorphine and clonidine challenge tests in healthy subjects. GH responses to apomorphine were significantly correlated with NS when peak relative values were considered (r=0.47, P=0.03). HA and RD did not show any relationships with the endocrine responses. In contrast, no significant relationship existed between GH responses to clonidine and any of the three temperament dimensions. These results gave another support of the hypothesized link between NS and dopaminergic central neurotransmission. In contrast, the results did not confirm the association between RD and noradrenergic central neurotransmission, probably because RD is poorly validated. This partial confirmation might suggest that the link between personality traits and neurotransmission systems is probably indirect. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailTreatment of mucocutaneous presentations of herpes simplex virus infections.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2002), 3(7), 475-87

Infections by herpes simplex virus (HSV) types I and II are diverse and quite frequent. After primary infection, the virus establishes a life-long latency in the sensory ganglia and recrudescences may ... [more ▼]

Infections by herpes simplex virus (HSV) types I and II are diverse and quite frequent. After primary infection, the virus establishes a life-long latency in the sensory ganglia and recrudescences may occur at an unpredictable rate. Recurrent labial and genital herpes infections represent the majority of clinical manifestations of HSV infections. Their management is currently well established using evidence-based medicine data. Primary labial herpes is generally not treated with antivirals in otherwise healthy children, although intravenous aciclovir may be offered in severe primary infections, particularly in the immunocompromised patient. The decision whether or not to treat recurrent labial herpes should be evaluated individually and depends on the frequency and severity of relapses, the impairment of the quality of life, and the cost of therapy. Patients with mild disease may benefit from topical therapy, and those with severe and frequent recurrences may be considered for intermittent or long-term oral antiviral therapy. Primary genital herpes is treated with oral or intravenous antivirals, depending on the severity of the infection and associated symptoms. Recurrent genital herpes can be managed with episodic short courses of oral antivirals in patients whose recurrences are moderate to severe and rare, and have a clear prodrome. Patients with >5 episodes/year, severe recurrences or unrecognisable prodromes may be best managed with long-term suppressive antiviral prophylaxis. HSV is also responsible for a variety of other clinical manifestations, including herpetic whitlow, neonatal infection, disseminated and atypical cutaneous infections, traumatic herpes, eczema herpeticum, and HSV-associated erythema multiforme. HSV infection may also represent a complication following cosmetic procedures of the oro-facial region, surgical and dental interventions, sun exposure and burns. Precise treatment guidelines for these HSV infections are not firmly established. [less ▲]

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See detailOxidative stress in equine medicine - Current knowledge
Kirschvink, Nathalie; Lekeux, Pierre ULg

in Pferdeheilkunde (2002), 18(6), 569-573

Oxidative stress has become of increasing interest in research and human medicine. Oxidants or reactive oxygen species are generated by metabolic reactions and play an important role for the immune ... [more ▼]

Oxidative stress has become of increasing interest in research and human medicine. Oxidants or reactive oxygen species are generated by metabolic reactions and play an important role for the immune defence and the "redox-regulation" of gene expression, In physiological conditions, different categories of antioxidants maintain the equilibrium between the pro-oxidant burden and the endogenous antioxidant defence. However, when an imbalance between oxidants and antioxidants in favour of oxidants occurs, oxidative stress might induce irreversible lesions that can be evidenced and characterised by oxidant markers. In equine medicine, it has been shown that oxidative stress is occurring in lower airway disease and equine motor neuron disease. Moreover, adopted antioxicants therapy appears to have a beneficial effect on the antioxidant-oxidant imbalance. Exercise-induced oxidative stress and its impact on animal welfare and performance are also under investigation in equine sports medicine, Oxidative stress has been demonstrated to cepend on exercise type, intensity and duration. It might be modulated by training and/or adopted antioxidant therapy, aiming to maintain the antioxidant-oxidant equilibrium and thereby to improve animal welfare. [less ▲]

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See detailModellierung von Faserbett-Koaleszenzabscheidern
Speth, H; Pfennig, Andreas ULg; Chatterjee, M et al

in Chemie Ingenieur Technik (2002), 74(3), 266-270

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See detailRepeated intracoronary beta radiation for recurrent in-stent restenosis.
De Benedetti, E; Latchem, D; Roguelov, C et al

in Catheterization and Cardiovascular Interventions (2002), 55(2), 233-236

More than 70% of percutaneous coronary interventions are followed by a stent implantation. In-stent restenosis still occurs in 20-30% of patients and remains a therapeutic challenge. At present only ... [more ▼]

More than 70% of percutaneous coronary interventions are followed by a stent implantation. In-stent restenosis still occurs in 20-30% of patients and remains a therapeutic challenge. At present only vascular brachytherapy has been shown to be an effective treatment option. We report here one case of recurrent in-stent restenosis after vascular brachytherapy that was successfully treated by a second beta radiation treatment. Cathet Cardiovasc Intervent 2002;55:233–236. © 2002 Wiley-Liss, Inc. [less ▲]

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See detailRecurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability.
Paquet, Philippe ULg; Jacob, Eric; Damas, Pierre ULg et al

in Critical Care Medicine (2002), 30(11), 2580-3

OBJECTIVE: A series of antibiotics may be responsible for toxic epidermal necrolysis. We report two successive episodes of toxic epidermal necrolysis in the same patient. Drug imputability criteria ... [more ▼]

OBJECTIVE: A series of antibiotics may be responsible for toxic epidermal necrolysis. We report two successive episodes of toxic epidermal necrolysis in the same patient. Drug imputability criteria designate a cross-reactivity between two antibiotics of different chemical classes but sharing the beta-lactam ring in common. DESIGN: Descriptive case report and review of the literature. SETTING: Medical intensive care unit in a university medical center. PATIENT AND MAIN RESULTS: A 75-yr-old woman developed a first episode of toxic epidermal necrolysis (involving 40% of the body surface) after intake of cefotaxime, a third-generation cephalosporin. Perfusions of high-dose immunoglobulins rapidly improved the lesions, followed by partial reepithelialization in 5 days. Sepsis required the administration of meropenem, which is a carbapenem antibiotic. The epidermal destruction immediately recurred, with extension to previously uninvolved skin areas and fatal consequences. CONCLUSIONS: The beta-lactam ring present in cephalosporins and carbapenems represents the putative chemical structure responsible for the presently reported cross-reactivity to two antibiotics of different classes. Drugs having any chemical similarity to the initial culprit compound should be strictly avoided when possible in the management of toxic epidermal necrolysis. [less ▲]

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See detailFédéralisme et extrême droite au Royaume-Uni
Jamin, Jérôme ULg

in Fédéralisme - Régionalisme (2002), 2

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See detailUntersuchung von Spaltungs- und Koaleszenzvorgängen in einer Messzelle mit pulsierten Füllkörpern
Klinger, S; Henschke, M; Pfennig, Andreas ULg

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