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See detailTranscription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer.
Timm, J; Perilli, M G; Duez, Colette ULg et al

in Molecular Microbiology (1994), 12(3), 491-504

The gene encoding a class A beta-lactamase was cloned from a natural isolate of Mycobacterium fortuitum (blaF) and from a high-level amoxicillin-resistant mutant that produces large amounts of beta ... [more ▼]

The gene encoding a class A beta-lactamase was cloned from a natural isolate of Mycobacterium fortuitum (blaF) and from a high-level amoxicillin-resistant mutant that produces large amounts of beta-lactamase (blaF*). The nucleotide sequences of the two genes differ at 11 positions, including two in the region upstream from the coding sequence. Gene fusions to Escherichia coli lacZ and transcription and expression analysis of the cloned genes in Mycobacterium smegmatis indicated that high-level production of the beta-lactamase in the mutant is mainly or wholly due to a single base pair difference in the promoter. These analyses also showed that transcription and translation start at the same position. A comparison of the amino acid sequence of BlaF, as predicted from the nucleotide sequence, with the determined N-terminal amino acid sequence indicated the presence of a typical signal peptide. The fusion of blaF (or blaF*) to the E. coli gene phoA resulted in the production of BlaF-PhoA hybrid proteins that had alkaline phosphatase activity. These results demonstrate that phoA can be used as a reporter gene for studying protein export in mycobacteria. [less ▲]

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See detailL'hyperthermie, une modalité oncologique pluridisciplinaire
Coucke, Philippe ULg; GUILLEMIN; RAIMONDI et al

in Médecine et Hygiène (1994), 52(2037), 1720-1722

L-hyperthermie consiste en l'élévation de la température du corps ou d'une de ses parties, par des moyens externes au-delà de 41°C. La chaleur a une activité cytotoxique propre et provoque une ... [more ▼]

L-hyperthermie consiste en l'élévation de la température du corps ou d'une de ses parties, par des moyens externes au-delà de 41°C. La chaleur a une activité cytotoxique propre et provoque une sensibilisation des cellules aux radiations ionisantes ou à la chimiothérapie. Le gain thérapeutique est environ de 2. Seules les tumeurs superficielles peuvent être traitées adéquatement par les moyens actuels. Les indications sont la palliation de tumeurs superficielles telles que les récidives loco-régionales du cancer du sein, les récidives ganglionnaires de cancers ORL et les cancers de la peau, en particulier les mélanomes [less ▲]

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See detailLa métropolisation, une nouvelle donne
Merenne-Schoumaker, Bernadette ULg

in Acta Geographica Lovaniensia (1994), (34), 165-174

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has ... [more ▼]

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has tackled successively four points: the concepts of metropolis and metropolization, the metropolization process, the metropolization and the city systems, the metropolization in Europe and Belgium. [less ▲]

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See detailInsulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.
Peers, Bernard ULg; Sharma, S.; Teitelman, G. et al

in Molecular Endocrinology (1994), 8(12), 1798-806

The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin ... [more ▼]

The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-expressing cells. The mechanism by which these peptide hormone genes are induced and then either maintained or repressed during development is unknown, but their coexpression in early precursor cells suggests the involvement of common regulatory factors. Here we show that the somatostatin transcription factor STF-1 is also a principal regulator of insulin expression in beta-cells of the pancreas. STF-1 stimulates the insulin gene by recognizing two well defined islet-specifying elements on the insulin promoter and by subsequently synergizing in trans with the juxtaposed helix-loop-helix protein E47. Within the STF-1 protein, an N-terminal trans-activation domain functions cooperatively with E47 to stimulate insulin transcription. As truncated STF-1 polypeptides lacking the N-terminal activation domain strongly inhibit insulin promoter activity in beta-islet cells, our results suggest that the specification of islet cell types during development may be in part determined by the expression of STF-1 relative to other islet cell factors. [less ▲]

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See detailLe financement au niveau communal
Jurion, Bernard ULg

in Mouvement communal, Union des Villes et des Communes de Belgique (1994)

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See detailEffet différentiel d'un didacticiel d'apprentissage de l'orthographe selon le mode d'utilisation de l'ordinateur
Crahay, Marcel ULg; Huberman, M.

in Education et Recherche (1994), 16(3), 300-326

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See detailAnalysis by in Situ Hybridization of Cytokine Mrnas Expression in Thymic Nurse Cells
Deman, J.; Humblet, Chantal ULg; Martin, M. T. et al

in Advances in Experimental Medicine and Biology (1994), 355

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See detailDetailed Study of a Molecule in a Molecule N-Acetyl-L-Tryptophanamide in a Active-Site Model of Alpha-Chymotrypsin
Dive, Georges ULg; Dehareng, Dominique ULg; Ghuysen, Jean-Marie ULg

in Journal of the American Chemical Society (1994), 116(6), 2548-2556

Six complexes between a model active site of alpha-chymotrypsin (261 atoms) and N-acetyl-L-tryptophanamide (33 atoms) were optimized at the semiempirical AM1 level. In one of these complexes, a water ... [more ▼]

Six complexes between a model active site of alpha-chymotrypsin (261 atoms) and N-acetyl-L-tryptophanamide (33 atoms) were optimized at the semiempirical AM1 level. In one of these complexes, a water molecule was included. A detailed study at the geometric and energetic levels is presented. The discussion deals with the nature of the interaction, the effect of the environment, the ligand deformation, the backbone relaxation, the water molecule freedom, and the comparison with the molecular mechanics results. [less ▲]

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See detailLes fleurs pâles du souvenir... Sur Guillaume Lekeu
Pirenne, Christophe ULg; Vendrix, Philippe ULg

in La Vie Wallonne (1994), 110

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See detailEtude épidémiologique de la toxoplasmose chez les femmes enceintes à Amiens (Picardie). Nécessité d'une enquête nationale
Carme, Bernard; Lenne, Evelyne; Tirard, Véronique et al

in Médecine et Maladies Infectieuses (1994), 24

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives ... [more ▼]

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives vis à vis de cette parasitose. Cette étude a permis de mettre en évidence la bonne connaissance des mesures préventives vis à vis de la toxoplasmose chez les femmes non immunes. Ceci a permis également de préciser les données épidémiologiques de la toxoplasmose à Amiens. Le choix d'un protocole incluant les femmes au moment de l'accouchement pourrait être complété par celui de femmes en début de grosesse pour éviter d'exclure les interruptions de grossesse. Cette étude devrait déboucher sur une enquête nationale qui permettrait de préciser l'épidémiolgoie de la toxoplasmose en France. [less ▲]

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See detailOptimisation du plan parcellaire d'une exploitation agricole: une application de la theorie des graphes.
Dupont, Pascal ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(3),

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See detailL'inventaire forestier wallon: un outil de developpement regional
Rondeux, Jacques ULg

in Wallonie (1994), 21(34), 3-8

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See detailGéologie de la région de Puagne, Bande de Sambre-et-Meuse (Belgique). Hypothèses basées sur l'état de maturation des palynomorphes fossiles
Steemans, Philippe ULg

in Comptes Rendus de l'Académie des Sciences. Série 2, Sciences de la Terre et des Planètes (1994), 318(11), 1551-1556

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See detailOnce-a-day administration of amikacin in neonates: clinical evidence of the validity of a pharmacokinetic according to the gestational age
Battisti, Oreste ULg; Wallemacq P; Langhendries JP

in Early Human Development (1994), 38

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See detailParametric Cubic Equations For Modeling Moldboard Plow Surfaces
Ravonison, Nm.; Destain, Marie-France ULg

in Soil & Tillage Research (1994), 31(4), 363-373

Mouldboard shape identification is needed to compare and analyse the performance of different plough bottoms. The paper presents a method for describing an existing mouldboard mathematically. The ... [more ▼]

Mouldboard shape identification is needed to compare and analyse the performance of different plough bottoms. The paper presents a method for describing an existing mouldboard mathematically. The technique used is based on a Bezier form of three dimensional parametric cubics and it focuses on an algorithm to improve the efficiency of approximation of a theoretical surface and the actual one. The method is well suited to describing mouldboard designs. [less ▲]

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See detailSynthesis of barium-titanate by the sol-gel process
LEMOINE, Christine; Gilbert, Bernard ULg; MICHAUX, Bernard et al

in Journal of Non-Crystalline Solids (1994), 175(1), 1-13

Homogeneous BaTiO3 gels were prepared by hydrolysis and polycondensation reactions between titanium isopropoxide and barium hydroxide in the presence of methoxyethanol, methanol and water. Gel formation ... [more ▼]

Homogeneous BaTiO3 gels were prepared by hydrolysis and polycondensation reactions between titanium isopropoxide and barium hydroxide in the presence of methoxyethanol, methanol and water. Gel formation mechanisms were investigated by Raman scattering spectrometry. Two drying methods are carried out: either in air with a possible formation of barium carbonate or in a vacuum furnace, sheltered from CO2. The influence of the drying method on texture is studied through nitrogen adsorption-desorption isotherm analyses. A heat treatment is deduced from thermogravimetry and differential scanning calorimetry results. The influence of the calcining temperature on the texture and the crystallization of the solids has been measured. For the first time, the transformation at 900 degrees C from the cubic to the tetragonal form of BaTiO3 has been observed by polarization microscopy. [less ▲]

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See detailSTRUCTURAL AND KINETIC CHARACTERIZATION OF A BETA-LACTAMASE-INHIBITOR PROTEIN
STRYNADKA, N. C. J.; JENSEN, S. E.; JOHNS, K. et al

in Nature (1994), 368(6472), 657-660

THE past decade has seen an alarming worldwide increase in resistance to beta-lactam antibiotics among many pathogenic bacteria1, which is due mainly to plasmid- or chromosomally encoded beta-lactamases ... [more ▼]

THE past decade has seen an alarming worldwide increase in resistance to beta-lactam antibiotics among many pathogenic bacteria1, which is due mainly to plasmid- or chromosomally encoded beta-lactamases that specifically cleave penicillin and cephalosporins, rendering them inactive. There is therefore a need to develop new strategies in the design of effective inhibitors of beta-lactamase. All the small-molecule inhibitors in clinical use are not very effective and are rapidly degraded2,3. Furthermore, newly characterized mutants of the plasmid-mediated beta-lactamase TEM-1 are highly resistant to these small-molecule inhibitors, including clavulanic acid and tazobactam4. It has been shown that Streptomyces clavuligerus produces an exocellular beta-lactamase inhibitory protein (BLIP; M(r) 17.5 K)5. Here we present data defining BLIP as the most effective known inhibitor of a variety of beta-lactamases, with K(i) values in the subnanomolar to picomolar range. To identify those features in BLIP that make it such a potent inhibitor, we have determined its molecular structure at 2.1 angstrom resolution. BLIP is a relatively flat molecule with a unique fold, comprising a tandem repeat of a 76-amino-acid domain. Each domain consists of a helix-loop-helix motif that packs against a four-stranded antiparallel beta-sheet (Fig. 1a). To our knowledge, BLIP is the first example of a protein inhibitor having two similarly folded domains that interact with and inhibit a single target enzyme. [less ▲]

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See detailMassive Ketonuria During Sedation with Propofol in a 12 Year Old Girl with Severe Head Trauma
Canivet, Jean-Luc ULg; Gustad, K.; Leclercq, P. et al

in Acta Anaesthesiologica Belgica (1994), 45(1), 19-22

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial ... [more ▼]

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial hypertension; as a part of our management protocol, glucose intake was restricted to 5 Kcal/h. After 18 hours of propofol infusion there was intense ketonuria (8+ by Ketostix) without any evidence of metabolic acidosis (pH, HCO3- and anion gap were within normal values). At this time, indirect calorimetry (Deltatrac) confirmed that energy expenditure was principally based on fat consumption (70% of energy expenditure). Lowering the propofol infusion rate and increasing glucose intake reduced fat consumption to 39% within 8 hours: at this time, Ketostix was negative for ketone bodies. This case illustrates a potential risk of ketonuria during prolonged sedation with propofol (a 10% solution of intralipid), particularly if glucose intake is restricted. Monitoring urinary ketone bodies is recommended under these circumstances. [less ▲]

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See detailA semiautomated test apparatus for studying partner preference behavior in the rat.
Bakker, Julie ULg; van Ophemert, J.; Eijskoot, F. et al

in Physiology & Behavior (1994), 56(3), 597-601

A semiautomated three-compartment box (3CB) for studying partner preference behavior of rats is described. This apparatus automatically records the rat's time spent in each compartment, as well as the ... [more ▼]

A semiautomated three-compartment box (3CB) for studying partner preference behavior of rats is described. This apparatus automatically records the rat's time spent in each compartment, as well as the locomotor activity (i.e., the number of visits an animal pays to each compartment). Software was developed for calculating partner preference scores. Behavioral testing in the semiautomated 3CB, which is a modification of an earlier version, is less time consuming and less laborious. Three 3CBs can be observed simultaneously by two trained observers, and the behavioral interactions of three experimental animals with the stimulus animals can be observed and scored by hand. The use of the new apparatus was validated by studying adult partner preference behavior of neonatally ATD-treated male rats. The collected data fully corroborate previous results, obtained in the earlier version of the 3CB, again revealing the behavioral bisexual nature of these ATD males. A new finding was the much higher locomotor activity of the ATD males compared to controls. [less ▲]

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See detailAssessment of the new immunological test Hemoblot for detecting occult blood in faeces
Jeanson, Antoinette; Jamart, J.; Maisin, J. M. et al

in European Journal of Cancer Prevention (1994), 3(5), 407-412

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and ... [more ▼]

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and with a guaiac test (Hemoccult II, SmithKline Diagnostics). The analytical sensitivity of Hemoblot is 0.15 mg haemoglobin/g faeces and the test is specific for human haemoglobin. In addition, 135 symptomatic patients who had to undergo a colonoscopy were tested using the three tests. Two criteria were considered for the analysis: (1) the blood criterion: any pathology likely to cause colorectal or other bleeding; and (2) the precancerous-cancerous criterion: the pathology being either a colorectal polyp > 0.5 cm or a colorectal cancer. Considering both criteria, the sensitivity of Hemoblot was significantly higher than the sensitivity of Hemoccult: 38% and 23%, respectively, for the blood criterion; and 54% and 29% for the precancerous-cancerous criterion. Sensitivity and specificity did not differ statistically between Hemoblot and HemeSelect but Hemoblot was faster and simpler to perform. It could be widely used in mass screening. [less ▲]

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See detailJean Capart ou la naissance de l’égyptologie belge
Winand, Jean ULg

in Egyptes (1994), 4

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See detailLe prix de la vie: une approche ex post
Faudemer, S.; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Risques (1994), (19), 117-132

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See detailComplete Dna-Sequence Of Yeast Chromosome-Xi
Dujon, Bernard; Esteban, Pf.; Fernandes, L. et al

in Nature (1994), 369(6479),

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See detailBacillus subtilis as a biopesticide : biochemical and technological aspects
Thonart, Philippe ULg; Heuze, V.; Destain, Jacqueline ULg et al

in Progress in biotechnology (1994), 9

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See detailConditional watershed segmentation for grain boundary reconstruction
Pirard, Eric ULg; Delanaye, Annick ULg

in Acta Stereologica (1994), 14(1), 23-28

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See detailModèles de cubage pour essences multi-tiges: application à des plantations d'acacia.
Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Cahiers Agricultures (1994), 3(3),

Des tarifs de cubage individuels ont été construits pour estimer le volume de plantations d'Acacia auriculiformis A. Cunn. ex Benth destinées à la production de bois de feu. Ces tarifs fournissent, d'une ... [more ▼]

Des tarifs de cubage individuels ont été construits pour estimer le volume de plantations d'Acacia auriculiformis A. Cunn. ex Benth destinées à la production de bois de feu. Ces tarifs fournissent, d'une part, le volume total incluant le bois de tiges et de branches jusqu'à une découpe de 9 cm de circonférence et, d'autre part, ce volume réparti en classes de circonférences de 9 à 14 cm, 15 à 44 cm et plus de 45 cm. Cette essence est généralement abondamment ramifiée, ce qui complique la détermination de son volume et interfère avec la caractérisation d'une variable dendrométrique déterminante, à savoir la circonférence ou le diamètre à 1,30m au-dessus du niveau du sol. Lorsque plusieurs tiges sont observées à 1,30m de hauteur, il est proposé de considérer une circonférence théorique résultant de la somme quadratique des circonférences des brins mesurés à ce niveau. Différentes équations de cubage mettant en oeuvre les circonférences à la base de l'arbre (niveau d'abattage) ou à 1,30m, ainsi que la hauteur totale, l'âge et le nombre de brins, sont proposées pour des plantations âgées de quelques dizaines de mois. En termes de compromis entre précision des estimations et coût des mesures, l'équation faisant intervenir la circonférence à 1,30m, l'âge et le nombre de brins s'est avérée la plus satisfaisante. En ce qui concerne les estimations de volume par assortiments, applicables à des plantations plus âgées, les équations ne faisant intervenir que la seule circonférence à 1,3m sont largement acceptables. [less ▲]

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See detailReduction of the acute bioavailability of metformin by the alpha-glucosidase inhibitor acarbose in normal man.
Scheen, André ULg; de Magalhaes, A. C.; Salvatore, T. et al

in European Journal of Clinical Investigation (1994), 24 Suppl 3

In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy ... [more ▼]

In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy young male volunteers was randomly allocated during two consecutive 7 day periods to either acarbose (days 1-3: 3 x 50 mg day-1; days 4-7: 3 x 100 mg day-1) or placebo. At day 7 and 14 of the study, the overnight-fasted subjects ingested 1000 mg metformin with the first bite of a standardized breakfast (500 kcal; 60 g carbohydrates) and together with either placebo or 100 mg acarbose. Acarbose significantly (P < 0.05) reduced the meal-induced increase in blood glucose and plasma insulin levels. Acarbose induced a significant (P < 0.05) reduction in early (90, 120, 180 min) serum levels, peak concentrations (Cmax: 1.22 +/- 0.14 vs. 1.87 +/- 0.60 mg l-1) and area under the curve of metformin (AUC 0-540 min: 423 +/- 55 vs. 652 +/- 55 mg min l-1), but did not diminish its 24 h urinary excretion. In conclusion, acarbose significantly reduces the acute bioavailability of metformin in normal subjects. [less ▲]

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See detailPlasmids for heavy metal resistance in Alcaligenes eutrophus CH34: Mechanisms and applications
Collard, Jean-Marc; Corbisier, Philippe; Diels, Ludo et al

in FEMS Microbiology Reviews (1994), 14

Alcaligenes eutrophus CH34 is the main representative of a group of strongly related strains (mostly facultative chemolithotrophs) that are well adapted to environments containing high levels of heavy ... [more ▼]

Alcaligenes eutrophus CH34 is the main representative of a group of strongly related strains (mostly facultative chemolithotrophs) that are well adapted to environments containing high levels of heavy metals. It harbors the megaplasmids pMOL28 and pMOL30 which carry resistance determinants to Co2+, Ni2+, CrO42-, Hg2+, Tl+, Cd2+, Cu2+ and Zn2+. Among the best characterized determinants are the cnr operon (resistance to Co, Ni) an pMOL28 and the czc operon on pMOL30 (resistance to Co, Cd and Zn). Although the two systems reveal a significant degree of amino acid similarity in the structural genes, the regulation of the operons is different. The resistance mechanism in both cases is based on efflux. The efflux mechanism leads to a pH increase outside of the cytoplasmic membrane. Metals are sequestered from the external medium through the bioprecipitation of metal carbonates formed in the saturated zone around the cell. This latter phenomenon can be exploited in bioreactors designed to remove metals from effluents. The bacteria are immobilized on composite membranes in a continuous tubular membrane reactor (CTMR). The effluent continuously circulates through the intertubular space, while the external surface of the tubes is in contact with the growth medium. Metal crystals are eventually removed by the effluent stream and collected on a glass bead column. The system has been applied to effluents containing Cd, Zn, Co, Ni and Cu. By introducing catabolic plasmids involved in the aerobic degradation of PCBs and 2,4-D into metal-resistant A. eutrophus strains, the application range was widened to include effluents polluted with both organic and inorganic substances. Biosensors have been developed which are based on the fusion of genes induced by metals to a reporter system, the lux operon of Vibrio fischeri. Bacterial luciferases produce light through the oxidation of fatty aldehydes. The gene fusions are useful both for the study of regulatory genes and for the determination of heavy metal concentrations in the environment. [less ▲]

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See detailFate of unstimulated Latissimus Dorsi transposed into the chest and applied to cardiomyoplasty
Radermecker, M. A.; Reznik, M.; Vivario, M. et al

in Research in Surgery (1994), 6(1), 35-39

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See detailL'identité wallonne saisie par l'enquête : une approche constructiviste de l'identité collective
Jacquemain, Marc ULg; Vandekeere, Michel; Doutrelepont, René

in Res Publica (1994), 26

The paper shows how a constructivist approach of collective identity makes sense of the use of survey data to approach regional walloon identity

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See detailEffect of recombinant human erythropoietin on platelets in patients with anemia of renal failure: correlation of platelet count with erythropoietic activity and iron parameters.
Beguin, Yves ULg; Loo, Martine; R'Zik, Samir ULg et al

in European Journal of Haematology (1994), 53(5), 265-70

We examined the effect of treatment with rHuEpo on platelet counts in 61 hemodialysis patients and correlated them with changes in erythropoietic activity, iron status and inflammation. Platelets (10(9)/1 ... [more ▼]

We examined the effect of treatment with rHuEpo on platelet counts in 61 hemodialysis patients and correlated them with changes in erythropoietic activity, iron status and inflammation. Platelets (10(9)/1) increased from 220 +/- 80 to 245 +/- 102 after 14 days and stabilized at that level up to day 90 (p < 0.0001). The increment was similar in complete or partial responders but was not observed in failures. Serum transferrin receptor (sTfR, a measure of total erythropoiesis) and Het rose much more progressively, but relative platelet increments correlated with relative increases in sTfR and Hct. Relative platelet increments correlated inversely with relative changes of SeFe or transferrin saturation, but not with their absolute values, nor with baseline ferritin or its progressive decrease. Although baseline platelet count was 12% higher in patients with inflammation and correlated with serum haptoglobin, relative increases were similar in patients with or without inflammation. In conclusion, rHuEpo produced a clinically minor but consistent elevation of platelet counts. These modifications were not related primarily to modifications in iron stores, functional iron deficiency, or inflammation, but paralleled the expansion of erythropoietic activity. The results suggest that rHuEpo has a small positive effect on platelet production, but it cannot be ruled out that this could be partially mediated through functional iron deficiency. [less ▲]

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See detailThe mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.
Wilkin, J M; Dubus, Alice ULg; Joris, Bernard ULg et al

in Biochemical Journal (1994), 301 ( Pt 2)

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the ... [more ▼]

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the active-site cavity. Thr299 corresponds to the second residue of the Lys-Thr(Ser)-Gly triad, highly conserved in active-site beta-lactamases and penicillin-binding proteins (PBPs). Modification of Thr301 resulted only in minor alterations of the catalytic and penicillin-binding properties of the enzyme. No selective decrease of the rate of acylation was observed for any particular class of compounds. By contrast, the loss of the hydroxy group of the residue in position 299 yielded a seriously impaired enzyme. The rates of inactivation by penicillins were decreased 30-50-fold, whereas the reactions with cephalosporins were even more affected. The efficiency of hydrolysis against the peptide substrate was also seriously decreased. More surprisingly, the mutant was completely unable to catalyse transpeptidation reactions. The conservation of an hydroxylated residue in this position in PBPs is thus easily explained by these results. [less ▲]

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See detailEvaluation du débit sanguin lors de contractions volontaires et évoquées électriquement
Vanderthommen, Marc ULg; Depresseux, J.C.; BAUVIR, Philippe ULg et al

in Kiné 2000 (1994), 5

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See detailExpression and function of DRC-1 antigen.
Bosseloir, A. L.; Antoine, Nadine ULg; Heinen, Ernst ULg et al

in Advances in Experimental Medicine and Biology (1994), 355

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See detailRelationship between alpha 2-adrenergic function and suicidal behavior in depressed patients.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Psychiatry Research (1994), 52(2), 115-23

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible implication of the noradrenergic function. In the present study, we assessed the growth hormone response to clonidine, a selective alpha 2-adrenergic agonist, in 15 DSM-III-R major depressive inpatients with a history of suicide attempts, compared with 15 age- and gender-matched major depressive inpatients without a history of suicidal behavior. Mean (+/- SD) growth hormone peak responses to clonidine were significantly lower in the group of suicide attempters than in the control group: 2.93 +/- 3.01 ng/ml vs. 8.28 +/- 8.15 ng/ml. Therefore, these results suggest that a blunted growth hormone response to clonidine could be a biological correlate of suicidal behavior. [less ▲]

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See detailCharacterization and Tumorigenicity of Spheroids Composed of Pigmented or Non Pigmented B16 Melanoma Cells
Coucke, P. H.; Gillet, Marie-Claire ULg; Bonjean, K. A. et al

in In Vivo (Athens, Greece) (1994), 8(3, May-Jun), 333-8

A parental line of mouse B16 melanoma cells (B16) and two derived cloned lines, either pigmented (B16P) or non pigmented (B16NP), were cultured in vitro as spheroids. After 48 hrs, the pigmented cells ... [more ▼]

A parental line of mouse B16 melanoma cells (B16) and two derived cloned lines, either pigmented (B16P) or non pigmented (B16NP), were cultured in vitro as spheroids. After 48 hrs, the pigmented cells (B16, B16P) formed smaller and looser aggregates, with higher rates of cell proliferation and lower amounts of extracellular matrix as compared to B16NP spheroids. The three lines were more tumorigenic when inoculated subcutaneously as spheroids than as isolated cells. Furthermore, B16P or B16 spheroids developed richly vascularized subcutaneous tumors and metastases more rapidly than B16NP aggregates. After intravenous injection of spheroids, the measurement with an image analyzer of the area of sections in lung colonies indicated that B16P colonies were larger and more numerous than those induced by B16NP cells. [less ▲]

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See detailEtude des relations entre les microstructures obtenues par vieillissement isotherme et le comportement mécanique (fatigue, résilience) dans des alliages Zn-Al et Zn-Al-Cu
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Wegria, J.

in Revue de Métallurgie [=Revue de Métallurgie. Cahiers d'Informations Techniques] (1994), 91[5]

L’article présenté établit une corrélation entre le comportement mécanique (fluage, résilience) et les microstructures qui apparaissent au cours d’un traitement thermique isotherme (100 ou 250 °C) dans ... [more ▼]

L’article présenté établit une corrélation entre le comportement mécanique (fluage, résilience) et les microstructures qui apparaissent au cours d’un traitement thermique isotherme (100 ou 250 °C) dans des alliages Zn-Al et Zn-Al-Cu1. Le but est de mettre en évidence l’intérêt pratique des modifications structurales obtenues. On observe un meilleur résultat pour des échantillons vieillis pendant une semaine environ. La température de traitement la plus favorable est 250 °C. De plus, les alliages contenant du cuivre possèdent un meilleur comportement que les alliages binaires Zn-Al. [less ▲]

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See detailBovine Leukaemia Virus: biology and mode of transformation
Burny, A.; Willems, Luc ULg; Callebaut, I. et al

in Viruses and Cancer, Cambridge University Press (1994)

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See detailAttitude vis-à-vis de l’école chez des enfants en âge d’école primaire, participant ou non à un programme scolaire d’activités physiques quotidiennes
Delfosse, Catherine; Cloes, Marc ULg; Ledent, Maryse et al

in Revue de l'Education Physique (1994), 34(2-3), 77-88

Les questions relatives aux attitudes et à leur modification font très largement partie des préoccupations relevées dans les environnements éducatifs considérés habituellement: l'école et le monde des ... [more ▼]

Les questions relatives aux attitudes et à leur modification font très largement partie des préoccupations relevées dans les environnements éducatifs considérés habituellement: l'école et le monde des loisirs actifs. A l'école, les objectifs d'un programme d'activités physiques et sportives sont évidemment de développer des attitudes favorables à l'égard de l'activité physique régulière. ... [less ▲]

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See detailLa maladie de Lyme : une nouvelle maladie?
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailErythropoietic activity and iron metabolism in autologous blood donors during recombinant human erythropoietin therapy.
Biesma, D. H.; Van de Wiel, A.; Beguin, Yves ULg et al

in European Journal of Clinical Investigation (1994), 24(6), 426-32

The use of recombinant human erythropoietin (rhEPO) to intensify the erythropoietic response in autologous donors may reduce homologous blood requirement. We studied the effect of subcutaneous rhEPO (500 ... [more ▼]

The use of recombinant human erythropoietin (rhEPO) to intensify the erythropoietic response in autologous donors may reduce homologous blood requirement. We studied the effect of subcutaneous rhEPO (500 U kg-1 body weight twice weekly during a 3 week period) on variables of erythropoiesis and iron metabolism in 62 autologous blood donors, of whom 32 received rhEPO (epo group) and 30 did not (control group). Patients donated only 2 units of blood and received oral iron in order to restrict phlebotomy-induced decrease of iron stores. Pre-phlebotomy haemoglobin concentration (14.0 +/- 0.8 g dl-1) was completely regenerated in the epo group at surgery (13.7 +/- 1.3 g dl-1); haemoglobin concentration in the control group fell from 13.5 +/- 1.4 g dl-1 to 11.6 +/- 1.4 g dl-1 after the phlebotomies and did not improve during the pre-operative phase. Total erythropoietic activity expressed as serum transferrin receptor concentration (sTfR) showed a 4-fold increase from 3.8 +/- 0.9 micrograms ml-1 to 14.9 +/- 4.8 micrograms ml-1 in the epo group. Effective erythropoietic activity measured by absolute reticulocyte count, however, declined after the fourth rhEPO injection in the epo group. Serum ferritin was lower in the epo group, but no differences in serum iron, transferrin concentration and transferrin saturation were observed between the groups. A marked increase in free erythrocyte protoporphyrin (FEP) was observed in the epo group, whereas FEP levels in the controls remained within normal ranges. Despite oral iron supplementation and the limited number of phlebotomies, the effect of rhEPO therapy in autologous donors is restricted by iron depletion. [less ▲]

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See detailAN IMPROVED ONE-POINT INTEGRATION METHOD FOR LARGE-STRAIN ELASTOPLASTIC ANALYSIS
Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in Computer Methods in Applied Mechanics & Engineering (1994), 118(1-2), 163-177

In this paper, we present a new one-point integration method generalizing Flanagan and Belytschko's method (Internat. J. Numer. Methods Engrg. 17 (1981) 679-706) and a modification of Belytschko and ... [more ▼]

In this paper, we present a new one-point integration method generalizing Flanagan and Belytschko's method (Internat. J. Numer. Methods Engrg. 17 (1981) 679-706) and a modification of Belytschko and Bindeman's method (Comput. Methods Appl. Mech. Engrg. 88 (1991) 311-340), both in the frame of large deformation elastoplastic analysis. These stabilization methods are combined with the radial return method used to integrate the constitutive law. Plane strain problems are first considered, and the method is then generalized to axisymmetrical situations. The explicit time integration scheme with its critical timestep is also considered. A few examples are presented that show the great time savings that can be obtained with reduced integration without any loss of accuracy, and even with a gain in the solution quality, since the underintegrated elements prove to be 'flexurally superconvergent'. [less ▲]

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See detailPilot trial of combined administration of erythropoietin and granulocyte colony-stimulating factor to children undergoing allogeneic bone marrow transplantation.
Locatelli, F.; Zecca, M.; Ponchio, L. et al

in Bone Marrow Transplantation (1994), 14(6), 929-35

We carried out a pilot study to evaluate the combined use of recombinant human erythropoietin (rhEpo) and granulocyte colony-stimulating factor (G-CSF) for accelerating marrow engraftment in children ... [more ▼]

We carried out a pilot study to evaluate the combined use of recombinant human erythropoietin (rhEpo) and granulocyte colony-stimulating factor (G-CSF) for accelerating marrow engraftment in children given allogeneic bone marrow transplantation (BMT). Fifteen consecutive children were enrolled in this study; 13 completed it and were evaluable. Using analysis of variance, laboratory and clinical data referring to these children were compared with those of 15 patients previously treated with rhEpo alone and with those of 16 historical controls. Erythroid repopulation, evaluated sequentially through serum transferrin receptor and reticulocyte count, was similarly accelerated in children receiving rhEpo alone and in those receiving combined treatment. These latter, however, showed a further reduction in the total number of red blood cell units required to reach transfusion independence (1.1 +/- 0.7 in the study population vs 2.7 +/- 1.2 in rhEpo group vs 4.2 +/- 2.3 in historical controls; values are mean +/- 1 SD; p < 0.001). Neutrophil engraftment, i.e. time for neutrophils to reach 0.5 x 10(9)/l, was 11 +/- 3 days in children receiving combined treatment, significantly shorter than that of the control groups (16 +/- 3 and 18 +/- 5, respectively; p < 0.001). Acceleration of neutrophil recovery translated into fewer infections: days of fever were significantly reduced in the study population (4 +/- 2 vs 11 +/- 8 vs 15 +/- 6, respectively).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailDNase I hypersensitive sites far upstream of the rat tryptophan oxygenase gene direct developmentally regulated transcription in livers of transgenic mice.
Kaltschmidt, Christian; Muller, Marc ULg; Brem, Gottfried et al

in Mechanisms of Development (1994), 45(3), 203-10

Expression of the gene coding for tryptophan oxygenase (TO) is switched on in rat liver about two weeks after birth. We identified two clusters of DNaseI hypersensitive (HS) sites in the TO gene upstream ... [more ▼]

Expression of the gene coding for tryptophan oxygenase (TO) is switched on in rat liver about two weeks after birth. We identified two clusters of DNaseI hypersensitive (HS) sites in the TO gene upstream region; one near the promoter, the other at a distant upstream location (-8.5 kb). Hypersensitivity of upstream sites was present in adult and in 7 day old rat liver, but absent in kidney. To investigate their role in transcriptional regulation, a reporter gene controlled by both HS site regions was used to generate transgenic mice. In these animals the transgene followed the cell specific and developmental regulation of the endogenous gene: inactive after birth and active in adult liver. Transgenes containing only the promoter proximal HS site were non-functional. [less ▲]

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See detailUse of recombinant human erythropoietin after bone marrow transplantation in pediatric patients with acute leukemia: effect on erythroid repopulation in autologous versus allogeneic transplants.
Locatelli, F.; Zecca, M.; Pedrazzoli, P. et al

in Bone Marrow Transplantation (1994), 13(4), 403-10

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) in children undergoing allogeneic or mafosfamide-purged autologous BMT for ALL or AML. rHuEPO was administered ... [more ▼]

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) in children undergoing allogeneic or mafosfamide-purged autologous BMT for ALL or AML. rHuEPO was administered intravenously at a dose of 75 U/kg/day for 30 days after transplant. Ten rHuEPO-treated patients receiving allogeneic BMT and 10 given autologous BMT were compared with 15 allogeneic and 10 autologous historical controls. Endogenous EPO production was appropriate for the degree of anemia after autologous BMT. In these patients, rHuEPO did not accelerate erythroid repopulation and did not modify transfusion requirements. With allogeneic BMT, erythroid marrow activity increased faster in patients given rHuEPO than in controls and resulted in higher red cell production, the mean reticulocyte count on day +30 being 187 +/- 51 x 10(9)/l in treated patients versus 107 +/- 63 x 10(9)/l in controls (p < 0.01). The total number of RBC units administered was 1.7 +/- 1.3 in the rHuEPO group versus 5.1 +/- 3.0 in the control group (p < 0.001). The total number of platelet transfusions was 4.0 +/- 2.3 for patients given allogeneic BMT and receiving rHuEPO versus 8.4 +/- 6.8 for historical controls (p < 0.05) whereas it was similar in rHuEPO-treated and control autologous BMT patients.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailLa formation des agents de santé scolaire dans le cadre du programme "Je mange bien à l'école"
Vandoorne, Chantal ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), (3),

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See detailImproved Experimental and Theoretical Energy Levels of Neon I
Chang, E. S.; Schoenfeld, W. G.; Biémont, Emile ULg et al

in Physica Scripta (1994), 49

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See detailEvaluation d’une expérience de rénovation de l’enseignement fondamental: Méthodologie de recherche
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine

in Revue de l'Education Physique (1994), 34(2-3), 117-120

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples ... [more ▼]

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples éclairages. Par les personnes auxquelles il s'adresse, par la diversité de ces effets et par l'organisation qu'il requiert, par la nécessité de mettre en évidence les relations de causalité, il a nécessité une méthodologie d'évaluation multidimensionnelle. ... [less ▲]

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See detailInteractions between the biofilm growth and the hydrodynamics in an aerobic trickling filter
Lekhlif, B.; Toye, Dominique ULg; Marchot, Pierre ULg et al

in Water Science & Technology (1994), 29

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See detailStructure and orientation of apo B-100 peptides into a lipid bilayer.
Lins, Laurence ULg; Brasseur, Robert ULg; Rosseneu, M. et al

in Journal of Protein Chemistry (1994), 13(1), 77-88

Peptides corresponding to lipid binding domains of Apo B-100 were synthesized, purified, and incubated with dimyristoylphosphatidylcholine (DMPC) liposomes. The secondary structure of the apo B-100 ... [more ▼]

Peptides corresponding to lipid binding domains of Apo B-100 were synthesized, purified, and incubated with dimyristoylphosphatidylcholine (DMPC) liposomes. The secondary structure of the apo B-100 peptide-lipid complexes was evaluated by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Those peptides belonging to the hydrophobic "core" domain of apo B-100 when associated with phospholipids were rich in beta sheet structure; a predominant alpha helical conformation was shown to be associated with one peptide located in a surface region of apo B-100. IR dichroic spectra revealed, in the case of the "core" peptides, that the beta sheet component is the only oriented structure with respect to the phospholipid acyl chains. This orientation of the beta sheet was recently found in LDL particles after proteolytic digestion by trypsin (Goormaghtigh, E., Cabiaux, V., De Meutter, J., Rosseneu, M., and Ruysschaert, J. M., 1993, Biochemistry 32, 6104-6110). Altogether, the data suggest that beta sheet, present in a high proportion in the native apo B-100, is probably another protein structure in addition to the amphipathic helix which strongly interacts with the lipid outer layer surrounding the LDL particle. [less ▲]

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See detailConstruction d'un modèle de répartition des arbres par classes de grosseur pour des plantations d'épicéa commun (Picea abies L Karst) en Ardenne belge
Lejeune, Philippe ULg

in Annales des Sciences Forestières (1994), 51(1), 53-65

The construction of a girth distribution model for Norway spruce (Picea abies L Karst) plantations has been considered using 141 sample plots of 1 000 m². The effects of the theoretical distribution ... [more ▼]

The construction of a girth distribution model for Norway spruce (Picea abies L Karst) plantations has been considered using 141 sample plots of 1 000 m². The effects of the theoretical distribution (comparison of the normal and Weibull distributions) and the estimation methods have been analysed. Despite the higher flexibility of the Weibull distribution, its use does not lead to a more accurate prediction of the distribution. The small number of samples measured in the plots seems to be the primary cause of the inaccuracy of the various models. Considering the data analysed, the normal distribution, which is easier to use, is proving to be more suitable for the creation of distribution model for such stands. [less ▲]

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See detailEtude comparative de six systèmes d'immunodosage de la ferritine sérique au cours de maladies rhumatismales
Revenant, M. C.; Vernet, M.; Rymer, J. C. et al

in Eurobiologiste (L') (1994), XXVIII(2), 35-41

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See detailDo canine scalene and sternomastoid muscles play a role in breathing?
De Troyer, A.; Cappello, M.; Brichant, Jean-François ULg

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1994), 76(1), 242-52

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on ... [more ▼]

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on the electrical activity of these muscles in 18 supine anesthetized spontaneously breathing animals. The sternomastoids never showed any activity, and the scalenes showed some inspiratory activity during occlusion in only two animals. The adoption of the prone position and bilateral cervical vagotomy did not affect this pattern. Hypercapnia also did not elicit any sternomastoid activity and induced scalene inspiratory activity during occlusion in only four of nine animals. On microscopic examination, however, both muscles were found to contain large numbers of spindles, suggesting that they have the capacity to respond to stretch. In addition, with increases in inspiratory resistance, both the sternum and ribs were displaced in the caudal direction. As a result, the scalenes demonstrated a gradual inspiratory lengthening and the normal inspiratory lengthening of the sternomastoids was accentuated. Additional studies in three unanesthetized animals showed consistent activity in the scalene and sternomastoid muscles during movements of the trunk and neck but no activity during breathing, including occluded breathing. These observations thus indicate that the alpha-motoneurons of the scalene and sternomastoid muscles in the dog have very small central respiratory drive potentials with respect to their critical firing threshold. In this animal, these muscles do not have a significant respiratory function. [less ▲]

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See detailHématome extradural cervical spontané de la femme enceinte
Mahieu, X.; Kridelka, Frédéric ULg; Pintiaux, Axelle ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(1), 99-102

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The ... [more ▼]

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The patient underwent first a caesarean and thereafter a prompt spinal surgical decompression. Complete sensory-motor recovery occurred after 48 hours. Differential diagnosis of cord compression, etiology of bleeding, conditions of recovery after surgery are discussed. [less ▲]

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See detailThe Unbearable Burden of Being: Janet Frame's "Snowman, Snowman"
Delrez, Marc ULg

in Commonwealth : Essays and Studies (1994), 17(1), 89-99

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See detailRock progressif et analyse musicale
Pirenne, Christophe ULg

in Art&Fact (1994), 13

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See detailControl of the Illegal Administration of Natural Steroid Hormones in the Plasma of Bulls and Heifers
Scippo, Marie-Louise ULg; Degand, Guy ULg; Duyckaerts, Anne et al

in Analyst (1994), 119(12), 2639-44

In the context of the control of the illegal administration of natural steroid hormones in cattle husbandry, an attempt was made to establish the decision levels for sex steroid hormones in the plasma of ... [more ▼]

In the context of the control of the illegal administration of natural steroid hormones in cattle husbandry, an attempt was made to establish the decision levels for sex steroid hormones in the plasma of adult cattle, taking into account the effect of the treatment. Bulls and heifers were treated with two injections, at a two week interval, of an estradiol-testosterone cocktail. Steroid hormone and biochemical precursor concentrations were measured in plasma samples by using specific radioimmunoassays, before and after the treatment. When the treatment significantly (p < 0.05) modified a hormone concentration, a decision level was established for that hormone concentration. At each decision level, a score was assigned that represented the percentage of treated animals detected when the decision limit was applied. For heifers, 17 beta-estradiol and testosterone concentrations in plasma, which increased after the treatment, are the best criteria to use to detect treated animals, with decision limits of 20 pg ml-1 and 125 pg ml-1, respectively. In the instance of bulls, both testosterone and steroid biochemical precursor concentrations decreased in the plasma after the treatment. We proposed decision limits of 1500 pg ml-1 and 28 pg ml-1 for testosterone and androstenedione concentrations, respectively, the bulls displaying concentrations below these limits being positive. We observed that the repetition of the injection increased the score of the decision limit. The scores for testosterone are 70%, 14d after the first injection and 100% 14 d after the second injection, and for androstenedione, these scores are 60 and 100%, respectively. [less ▲]

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See detailAlienating Language and Darl's Narrative Consciousness in As I Lay Dying
Delville, Michel ULg

in The Southern Literary Journal (1994)

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See detailLes indices de déformation plio-quaternaire de la bordure occidentale du bassin des Iullemenden dans la région de Niamey (Niger).
Vicat, Jean-Paul; Léger, Jean-Marc; AHMED, Y et al

in Revue de Géographie Alpine (1994), 5

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See detailAbnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.
Van Cauter, E. V.; Polonsky, K. S.; Blackman, J. D. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 79(6), 1797-805

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep ... [more ▼]

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep, 28 h of continuous wakefulness, and 8 h of daytime sleep. Blood samples were collected at 20-min intervals to assay glucose, insulin, C-peptide, cortisol, and GH. Sleep was polygraphically monitored. Abnormal temporal profiles of glucose regulation were observed during wakefulness and sleep in obese subjects. During daytime hours, the normal profile of glucose tolerance was reversed, as an improvement, rather than a deterioration, was observed from morning to late evening. This reversal of the daytime pattern appeared to be caused by a dual defect in glucose regulation during the previous night. Indeed, during early sleep, GH secretion was markedly reduced, and the nocturnal rises of glucose and insulin secretion were dampened. During late sleep, obese subjects failed to suppress insulin secretion and plasma glucose, resulting in high morning levels. Comparisons of metabolic and hormonal patterns during nocturnal and daytime sleep suggest that the failure to suppress insulin secretion in late sleep may reflect a relative insensitivity of the beta-cell to acute inhibitory effects of cortisol in addition to insulin resistance. [less ▲]

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See detailFunctional Sites Of The Bovine Leukemia-Virus Envelope Glycoproteins Using Structural And Immunological Data
Callebaut, I.; Mornon, Jp.; Burny, A. et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailDetection of early sympathetic cardiovascular neuropathy by squatting test in NIDDM.
Marfella, R.; Salvatore, T.; Giugliano, D. et al

in Diabetes Care (1994), 17(2), 149-51

OBJECTIVE--To determine the role of the squatting test in the detection of early sympathetic neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--Three ... [more ▼]

OBJECTIVE--To determine the role of the squatting test in the detection of early sympathetic neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--Three groups of nonsmoking, nonobese subjects were studied: 10 healthy subjects, 10 NIDDM patients without autonomic neuropathy (AN), and 10 NIDDM patients with AN defined by the presence of a pathological deep-breathing value. All subjects were given three postural tests: lying-to-standing, sitting-to-standing, and squatting test. Heart rate (HR) and finger arterial pressure were recorded with a noninvasive technique. RESULTS--Blood pressure (BP) fall (expressed as decremental area) was not significantly different among the groups at standing up after sitting or lying. By contrast, a significantly greater BP drop occurred in NIDDM patients with AN (1,123 +/- 245 mm2) compared with NIDDM patients without AN (460 +/- 232 mm2) or normal subjects (429 +/- 138 mm2, P < 0.001). The HR increase after all the orthostatic maneuvers was smaller in diabetic patients with AN (P < 0.01) compared with that recorded in other groups. Significant correlations were observed between BP fall after squatting and either the expiration:inspiration ratio at deep breathing (r = -0.77, P < 0.001) or the duration of diabetes (r = 0.76, P < 0.001). CONCLUSIONS--The intrinsic orthostatic load of the squatting test, which is greater than conventional postural maneuvers, makes the squatting test an easy and useful test to detect early orthostatic dysregulation in NIDDM. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Bouwen met Staal (1994), n°117

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See detailThe use of acarbose in the prevention and treatment of hypoglycaemia.
Lefebvre, Pierre ULg; Scheen, André ULg

in European Journal of Clinical Investigation (1994), 24 Suppl 3

This paper reviews the use of acarbose in the prevention and treatment of hypoglycaemia. In diet- or sulfonylurea-treated patients, acarbose may reduce the incidence of late postprandial hypoglycaemia. In ... [more ▼]

This paper reviews the use of acarbose in the prevention and treatment of hypoglycaemia. In diet- or sulfonylurea-treated patients, acarbose may reduce the incidence of late postprandial hypoglycaemia. In insulin-treated patients, acarbose treatment usually requires reduction of the insulin dose; one study has shown that 100 mg acarbose at night significantly reduces the incidence of mid-evening and nocturnal hypoglycaemia. Several studies have suggested acarbose to be a useful adjunct to the management of reactive hypoglycaemia in the non-diabetic patients. Long-term prospective studies are still needed to document this last indication of acarbose or other alpha-glycosidase inhibitors. [less ▲]

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See detailEst-ce ainsi que les jeunes Belges lisent? Résultat d'une enquête internationale
Lafontaine, Dominique ULg; Lafontaine, Annette ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1994), 31(7), 31

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See detailIsolation of the missing 5-end of the encoding region of the bovine leukemia virus cell receptor gene.
Ban, J.; Truong, A. T.; Horion, B. et al

in Archives of Virology (1994), 138(3-4),

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See detailMeasurement of apolipoproteins B and A by radial immunodiffusion: methodological assessment and clinical applications.
Cano, M. D.; Gonzalvo, C.; Scheen, André ULg et al

in Annales de Biologie Clinique (1994), 52(9), 657-61

The clinical evaluation of apolipoproteins is of interest in order to characterize the risk profile for ischemic heart disease both in normolipidemic and hyperlipidemic subjects. In the non-specialized ... [more ▼]

The clinical evaluation of apolipoproteins is of interest in order to characterize the risk profile for ischemic heart disease both in normolipidemic and hyperlipidemic subjects. In the non-specialized and/or small practice clinical laboratory, the measurement of some apolipoproteins can be undertaken by simple methods of immunological analysis, among which radial immunodiffusion can be of interest due to its simplicity of use and because it does not require specific equipment. In this work several methodological questions concerning the measurement of plasma apolipoproteins B and A by radial immunodiffusion have been addressed; the results show that this method is particularly reliable for the apo B assay. Regression analysis between values obtained with radial immunodiffusion and radioimmunoassay was r = 0.972 for apo B and r = 0.782 for apo A. The recovery rate was above 90% for both apolipoproteins (93.8% for apo B and 99.5% for apo A). The inter and intraassay coefficients of variation were below 5%, and the detection limits were estimated as 9.6 mg/dl for apo A and 6.9 mg/dl for apo B. Neither the ingestion of a standard breakfast (500 Cal, 17 g fat, 120 mg cholesterol) 2 h prior to testing nor freezing the sample significantly affected the measurement of apolipoproteins B and A. Mean plasma concentrations of both apolipoproteins measured by radial immunodiffusion in normo and hyperlipidemic subjects are also presented. [less ▲]

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See detailCrise de presse. Le journalisme au péril du « reportage » (France, 1870-1890)
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1994), 24(automne), 123-152

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See detailTamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype
Bracke, M. E.; Charlier, Corinne ULg; Bruyneel, E. A. et al

in Cancer Research (1994), 54

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See detailEnzyme Immobilization in Nanoparticles produced by Inverse Microemulsion Polymerization
Daubresse, Catherine; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Colloid & Interface Science (1994), 168

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See detailThe experience of the CHU Liege with conservative surgery in the management of upper urinary tract tumors.
Bouffioux, Christian ULg; Andrianne, Robert ULg; Bonnet, Pierre ULg et al

in Acta Urologica Belgica (1994), 62(4), 39-43

A review of 20 cases of conservative surgery for urothelial tumors of the upper tract is presented. The morbidity is limited; the recurrence rate is around 15% in the ipsilateral urinary tract with a mean ... [more ▼]

A review of 20 cases of conservative surgery for urothelial tumors of the upper tract is presented. The morbidity is limited; the recurrence rate is around 15% in the ipsilateral urinary tract with a mean follow up of 41 months. Conservative surgery does not seem to carry a higher fatal risk as compared to more radical surgery. It has indications in some cases which are defined. [less ▲]

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See detailLe tamoxifene dans le traitement du cancer du sein
Charlier, Corinne ULg; Colin, Claude ULg; Merville, Marie-Paule ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(7), 751-6

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on ... [more ▼]

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on oral adjuvant therapy in the early stages of breast cancer. A significative regression of the tumour was observed in most cases. Moreover, recent epidemiological studies suggest that tamoxifen could prevent new contralateral primary tumours. The risk of the disease should thus be reduced by the prophylactic use of antioestrogens such as tamoxifen. Investigations using a variety of models have evaluated the effect of tamoxifen on tumour promotion and cell growth. Tamoxifen-induced growth inhibition is associated with major changes in biochemical events in cultured human breast cancer cells including cell proliferation or growth factor production. Growth inhibition of oestrogen-responsive human breast cancer cells is associated with an induced secretion of autoinhibitory polypeptides (TGF beta) and an antagonistic effect on the synthesis of proliferative proteins (TGF alpha,...). The first step in the mechanism of action of the drug is binding of tamoxifen to the oestrogen receptors. Development of resistance to tamoxifen treatment is a great problem in treatment of breast cancer patients and the mechanism of resistance will require further study: under the influence of the drug, tumours could become remodelled as selected subpopulations emerge resistant-tamoxifen. The fact that some breast cancers which are oestrogen receptor-negative respond to antioestrogen suggests that parallel but separate pathways for oestrogen and antioestrogen action may exist. This paper summarizes the results of the most recent studies concerning this promising drug. [less ▲]

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See detailAsthme et hyperréactivité bronchique non spécifique
Louis, Renaud ULg; Kayembe, J. M.; Radermecker, Maurice ULg

in Acta Clinica Belgica (1994), 49(3-4), 148-57

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes ... [more ▼]

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes modifying the functional status of airway smooth muscle as well as the structure of the bronchial wall. The responsiveness toward a direct constricting pharmacological agent is poorly correlated to the one toward an indirect constricting agent or a physical stimulus which cause airway obstruction through a more complex mechanism. Transversal studies show a relationship between the severity of asthma and the level of methacholine airway responsiveness. Long term treatment with corticoids can reduce the bronchial hyperresponsiveness of asthmatics. [less ▲]

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See detailTechniques moleculaires de detection et d'identification des agents phytopathogenes.
Lepoivre, Philippe ULg; Kummert, J.; Colinet, D. et al

in Cahiers Agricultures (1994), 3(4),

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See detailLaparoscopic adrenalectomy in pheochromocytoma and Cushing's syndrome. Reflections about two case reports.
Meurisse, Michel ULg; Joris, Jean ULg; Hamoir, Etienne ULg et al

in Acta Chirurgica Belgica (1994), 94(6), 301-6

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open ... [more ▼]

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open method. In combination with intraoperative infusion of nicardipine, a calcium-channel blocker, the laparoscopic removal of a pheochromocytoma was performed safely and under stable conditions. In case of Cushing's syndrome, the laparoscopic approach reduces the problems related to poor healing. In all cases of laparoscopic adrenalectomy, this approach could offer the clear advantages of smaller incisions, reduced postoperative pain and incisional discomfort as well as complications related to large and invasive procedure and finally allows quicker recovery. Moreover, conversion to open surgery remains always possible, if needed. [less ▲]

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See detailLate Devonian-Early Carboniferous miospores from the Menen borehole, Namur Synclinorium, Belgium
Loboziak, S.; Streel, Maurice ULg; Dusar, M. et al

in Review of Palaeobotany and Palynology (1994), 80(1/2), 55-63

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See detailLe plan régional d'aménagement du territoire wallon
Delnoy, Michel ULg; Pâques, Michel ULg

in Aménagement - Environnement (1994), n° spécial

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See detailAcute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study.
Dahchour, Abdelkhader; Quertemont, Etienne ULg; De Witte, Philippe

in Alcohol & Alcoholism (1994), 29(5), 485-7

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain ... [more ▼]

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain nucleus accumbens were studied by the microdialysis technique coupled to HPLC-EC detection. Levels of GLU and GABA were not affected by ethanol, whereas those of TAU were increased by doses of the drug of 2-3 g/kg. [less ▲]

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See detailComparaison de plusieurs types d'unités d'échantillonnage dans la perspective d'un inventaire forestier régional.
Lecomte, H.; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Forestry Chronicle (1994), 70(3), 304-310

This study has been conducted in order to define the guidelines of a permanent forest inventory methodology that could applied to heterogenous forests located in the southern part of Belgium. Different ... [more ▼]

This study has been conducted in order to define the guidelines of a permanent forest inventory methodology that could applied to heterogenous forests located in the southern part of Belgium. Different types of sampling units generally used in European national inventories have been compared: fixed area sampling units (based upon 3 concentric circles), non fixed-area sampling units (Bitterlich plots using basal area factor of 2 and 4) and sampling units based upon a minimum number of trees (including nearly 15 measurable trees). In true conditions of application 259 sampling points have been selected according to a systematic rectangular grid (1.000 m x 500 m). Taking into account different criteria such as precision, cost and ease of use, the fixed-area sampling unit looks like the most adequate among the four types investigated. [less ▲]

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See detailUse Of Bacteria Protections In Pelleting For Preinoculation Of Bean-Seeds (Phaseolus-Vulgaris L)
Jansen, Jp.; Schiffers, Bruno ULg; Mathot, P. et al

in Seed Science and Technology (1994), 22(2), 329-336

Preinoculation of bean seeds (Phaseolus vulgaris L.) with Rhibozium phaseoli material has been carried out by incorporating the inoculum in seed pelleting. An inoculum was incorporated into a mixture of ... [more ▼]

Preinoculation of bean seeds (Phaseolus vulgaris L.) with Rhibozium phaseoli material has been carried out by incorporating the inoculum in seed pelleting. An inoculum was incorporated into a mixture of vermiculite and compost or wheat bran, and applied to seeds to produce a solid pellet. The pelleted seed contained a sufficient number of bacteria per seed for effective nodulation after 56 days storage of preinoculated pelleted seeds at 25°C. Those results are not achieved using a liquid inoculum of Rhibozium. [less ▲]

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See detailT-CELLS SKIN LYMPHOMA IN 3 DOGS
Gilbert, S.; Clercx, Cécile ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1994), 138(8), 587-595

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See detailGestion d'un épisode de peste porcine classique en Belgique
Vanthemsche, P.; Saegerman, Claude ULg

in Epidémiologie et Santé Animale (1994), 26

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See detailL'analyse des glucosinolates, travaux réalisés par l'Organisation internationale de standardisation et la CEE
Wathelet, Jean-Paul ULg; Ribaillier, Daniel; Severin, Michel et al

in Bulletin du GCIRC (1994)

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See detailMax Ophuls : le cristal et la tache
Belloi, Livio ULg

in Cinémathèque (1994), 6(automne),

Cette étude porte sur les quatre derniers films de Max Ophuls ("La Ronde", "Le Plaisir", "Madame de" et "Lola Montès") et s'attache à révéler, en eux, une forme de dilemme du visible (entre transparence ... [more ▼]

Cette étude porte sur les quatre derniers films de Max Ophuls ("La Ronde", "Le Plaisir", "Madame de" et "Lola Montès") et s'attache à révéler, en eux, une forme de dilemme du visible (entre transparence et opacité) que la modernité cinématographique inscrira résolument à son ordre du jour. [less ▲]

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See detailCaracteristiques des phosphatases acides de l'orge en condition de stress hydrique.
Ben-Naceur, M'B.; Paul, Roger ULg; Portetelle, Daniel ULg et al

in Cahiers Agricultures (1994), 3(4),

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See detailHIGH-RESOLUTION SPECTRA OF JUPITER NORTHERN AURORAL ULTRAVIOLET EMISSION WITH THE HUBBLE-SPACE-TELESCOPE
TRAFTON, L. M.; Gérard, Jean-Claude ULg; Munhoven, Guy ULg et al

in Astrophysical Journal (1994), 421(2), 816-827

The first spectroscopic observations of planetary aurora with the HST are reported. These include spectral regions centered on the H-2 Lyman and Werner bands of a region of Jupiter's northern aurora. The ... [more ▼]

The first spectroscopic observations of planetary aurora with the HST are reported. These include spectral regions centered on the H-2 Lyman and Werner bands of a region of Jupiter's northern aurora. The observations were made with the Goddard High Resolution Spectrograph (GHRS) using the Large Science Aperture as part of a campaign to study Jupiter at the time of the Ulysses flyby. The individual rotational-vibrational bands are resolved and the observed emissions are essentially all from H-2. A rotational-vibrational temperature for H-2 of 530 +/- 100 K is derived, a value significantly less than the 850-1100 K reported for Jovian H-3(+) in the near-infrared but consistent with the temperature reported for fundamental-band quadrupole H-2 emission. Comparison with the Faint Object Camera (FOC) images shows that the observed region was not one of the hot spots of the aurora. The results are interpreted in terms of electron impact excitation of H-2 from secondary particles generated by primaries precipitating into Jupiter's atmosphere from the magnetosphere. In the region of the aurora observed, the homopause level is found to be significantly hotter but not necessarily higher than observed at nonauroral latitudes. The equatorial H-2 dayglow spectrum was also detected; its intensity was 3.2 kR or 13% of the strength of the observed auroral emission. [less ▲]

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See detailLe paradis d'une ville au siècle de Louis XIV
George, Philippe ULg

in Annales du Cercle Hutois des Sciences et Beaux-Arts (1994), XLVIII

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See detailMeasurement of Right Ventricular Ejection Fraction and Volume by the Thermodilution Technique in the Unsedated Calf
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1994), 56(1), 75-81

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end ... [more ▼]

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in unsedated cattle. In the 16 healthy calves studied, it was possible, using a fast response thermodilution catheter, to obtain characteristic exponential steplike washout curves, allowing the calculation of right ventricular EF, EDV and ESV. Five to 10 successive thermodilution curves were recorded within a few minutes and two to five similar sets of measurements were performed throughout the same day to test the reproducibility of the technique. The same protocol was repeated the following day. Right ventricular EF, EDV and ESV were reproducible successively, throughout a given day and on following days. The mean intraset, intraday and interdays coefficients of variation ranged from a mean of 4.0 (SD 4.1) per cent to a mean of 18.2 (SD 7.9) per cent. Values of right ventricular volumes and EF agreed with those previously reported in various animal species. Thermodilution was, therefore, shown to be a useful method for measuring with a satisfactory reproducibility, right ventricular EF, EDV and ESV in the unsedated healthy calf [less ▲]

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See detailDifferential diagnosis of Alzheimer's disease with PET.
Salmon, Eric ULg; Sadzot, Bernard ULg; Maquet, Pierre ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1994), 35(3), 391-8

PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias ... [more ▼]

PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias. METHODS: To evaluate the diagnostic power of cerebral metabolic distribution patterns for "cortical" degenerative dementias, PET scans obtained from 129 patients referred for differential diagnosis of dementia were analyzed visually. RESULTS: Sixty-five patients had a final clinical diagnosis of probable AD. Ninety-seven percent (97%) of those had abnormal metabolic scans and 94% showed a suggestive pattern of bilateral or unilateral temporo-parietal hypometabolism (with or without frontal involvement). Hypometabolism was unilateral in 23% of patients. Five subjects with a neuropathologically proven diagnosis of Alzheimer's disease had a suggestive metabolic pattern. One of those was an early case with frontal hypometabolism exceeding temporo-parietal involvement. Two patients with Alzheimer's-type dementia had isolated bilateral frontal hypometabolism. CONCLUSIONS: This alternative metabolic pattern may correspond to a non-Alzheimer pathology occurring in 10%-20% of patients suffering from clinically probable Alzheimer's disease. Most of the patients with possible but atypical Alzheimer's-type dementia showed isolated bilateral frontal involvement. This metabolic pattern probably corresponds to different diseases, such as Pick's disease, frontal lobe dementia or progressive subcortical gliosis. [less ▲]

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See detailCharacterization of a single strong tissue-specific enhancer downstream from the three human genes encoding placental lactogen
Jacquemin, Patrick; Oury, Cécile ULg; Peers, Bernard ULg et al

in Molecular & Cellular Biology (1994), 14(1), 93-103

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3 ... [more ▼]

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3'. So far, a single placenta-specific enhancer has been identified in the locus, 2 kb downstream from the hCS-B gene, and shown to comprise one in vitro binding site for a nuclear protein. We here provide evidence that the hCS-B enhancer is more complex: (i) protection against DNase I digestion in the 3' flanking region of the hCS-B gene reveals four binding sites (DF-1, DF-2, DF-3, and DF-4) for nuclear proteins from either placental or HeLa cells, and (ii) placenta-specific enhancer activity can be fully exerted in transient expression experiments by a 126-bp fragment comprising the DF-3 and DF-4 protein-binding sites. By dissecting this region, we show that enhancer activity is mediated by a synergy between DF-3 and DF-4. Competitions with various oligonucleotides in footprinting and gel retardation experiments indicate that the same protein or set of proteins, different in HeLa and placenta cell nuclei, interacts with sites DF-2, DF-3, and DF-4. We also studied the regions of the hCS-L and hCS-A genes which are highly similar to the hCS-B enhancer. Although they each present the same four protein-binding sites, they exhibit only minor enhancer activity. [less ▲]

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See detailCrystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme
Mande, S. C.; Mainfroid, V.; Kalk, K. H. et al

in Protein Science : A Publication of the Protein Society (1994), 3(5), 810-21

The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement ... [more ▼]

The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement, the R-factor is 16.7% with good geometry. The asymmetric unit contains 1 complete dimer of 53,000 Da, with only 1 of the subunits binding the inhibitor. The so-called flexible loop, comprising residues 168-174, is in its "closed" conformation in the subunit that binds the inhibitor, and in the "open" conformation in the other subunit. The tips of the loop in these 2 conformations differ up to 7 A in position. The RMS difference between hTIM and the enzyme of Trypanosoma brucei, the causative agent of sleeping sickness, is 1.12 A for 487 C alpha positions with 53% sequence identity. Significant sequence differences between the human and parasite enzymes occur at about 13 A from the phosphate binding site. The chicken and human enzymes have an RMS difference of 0.69 A for 484 equivalent residues and about 90% sequence identity. Complementary mutations ensure a great similarity in the packing of side chains in the core of the beta-barrels of these 2 enzymes. Three point mutations in hTIM have been correlated with severe genetic disorders ranging from hemolytic disorder to neuromuscular impairment. Knowledge of the structure of the human enzyme provides insight into the probable effect of 2 of these mutations, Glu 104 to Asp and Phe 240 to Ile, on the enzyme. The third mutation reported to be responsible for a genetic disorder, Gly 122 to Arg, is however difficult to explain. This residue is far away from both catalytic centers in the dimer, as well as from the dimer interface, and seems unlikely to affect stability or activity. Inspection of the 3-dimensional structure of trypanosomal triosephosphate isomerase, which has a methionine at position 122, only increased the mystery of the effects of the Gly to Arg mutation in the human enzyme. [less ▲]

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See detailParadoxe sur le philosophe (kant entre Bourdieu et Derrida)
Steinmetz, Rudy ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994)

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See detailLe diabète insipide central : l'étiologie n'est pas toujours évidente
Geenen, Vincent ULg

in Actualité Médicale Belge (1994), 444

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See detailRelations à autrui et abus sexuel chez de jeunes délinquantes
Spitz, J.; Born, Michel ULg

in Bulletin de Criminologie (1994), 1

L'analyse des relations qu'entretiennent des adolescentes délinquantes avec leur entourage met en évidence des différences significatives selon que celles-ci ont été victimes ou non d'un abus sexuel dans ... [more ▼]

L'analyse des relations qu'entretiennent des adolescentes délinquantes avec leur entourage met en évidence des différences significatives selon que celles-ci ont été victimes ou non d'un abus sexuel dans leur enfance. Les rapports interpersonnels des adolescentes abusées se caractérisent par l'ambivalence et la dépendance, alors qu'une dimension de pouvoir et de domination détermine ceux des adolescentes non abusées. La prise en compte du niveau de maturité sociale de ces adolescentes, parallèlement à leurs modes de relations, permet la comparaison avec les types de délinquantes décrits par Margaret Warren et donne un sens particulier à leur délinquance persistante. [less ▲]

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