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See detailThe relation of ventilatory failure to pulmonary, respiratory muscle and central nervous system disturbances in calves with an experimentally produced pneumonia
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Journal of Comparative Pathology (1996), 115(3), 203-219

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a ... [more ▼]

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a period of 10 h. Measurements were made of inspired minute ventilation VE), ventilatory pattern [inspiratory time (TI), expiratory time (TE), respiratory rate (RR) and tidal volume (VT)], transdiaphragmatic pressure (Pdi), occlusion pressure at the airway opening 100 milliseconds after onset of inspiration (Pawo100ms), arterial blood gas tensions and pH and recorded diaphragmatic electromyogram (EMGdi) and rectal temperature (Tr). On and after the third hour after inoculation, the animals varied in respect of clinical signs, Tr, RR, VE, Pawo100ms/EMGdi, and arterial gases and pH. In benign cases, diminished alertness, laboured respiration and fall of arterial oxygen pressure (PaO2) worsened up to 7 h after inoculation, but then progressively improved, VE being maintained at approximately 150% baseline throughout the study (10 h). Neither arterial carbon dioxide pressure (PaCO2) nor pH was altered. Moderate cases resembled benign cases in respect of laboured respiration, VE, PaO2 and PaCO2; however, pH was at first maintained at preinoculation levels, but declined thereafter. In severe cases, the animals were drowsy between hours 3 and 7, and became comatose between hours 8 and 10; in contrast to both benign and moderate cases: (1) RR was reduced by hour 5, (2) there was no trend towards recovery of PaO2 and pH, (3) VE, Pdi, Pawo100ms and Pawo100ms/EMGdi were severely decreased, and (4) PaCO2 increased. These results suggest that pneumonia does not alter ventilatory neuromuscular pump function in calves, unless concomitant cardiovascular collapse occurs. It is not clear whether fatal ventilatory failure is caused mainly by deterioration in ventilatory muscle fibre processes or structures, altered central nervous system adjustment of ventilatory timing, or cardiovascular dysfunction. However, inspiratory pressures fall when excitation to the diaphragm is still growing, which suggests peripheral respiratory muscle fatigue. [less ▲]

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See detailTheoretical Radiative Lifetimes of 3p3(4S°)4s5S° and 3S° States in S I
Biémont, Emile ULg; Storey, P. J.; Zeippen, C. J.

in Astronomy and Astrophysics (1996), 309

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See detailThe equatorial boundary of the ultraviolet Jovian north aurora observed with multispectral Hubble Space Telescope images
Grodent, Denis ULg; Dols, V.; Gérard, Jean-Claude ULg et al

in Journal of Geophysical Research (1996), 101(E1), 2163-2168

Multispectral observations of the far ultraviolet Jovian aurora with the faint object camera (FOC) on board the Hubble Space Telescope are reported. They are used to describe and compare the morphology ... [more ▼]

Multispectral observations of the far ultraviolet Jovian aurora with the faint object camera (FOC) on board the Hubble Space Telescope are reported. They are used to describe and compare the morphology and the mean brightness of the H-2 Lyman and Werner bands observed at 153, 125, and 130 nm. It is shown that most of the emissions are confined inside the 6 R(J) O-6-GSFC auroral oval and fill a large fraction of the polar cap. During the similar to 50 hours time span of the observations following a very strong aurora, no bright are was observed along the oval mapping the 30 R(J) O-6 oval. Hydrogen emissions at 125 and 130 nm are observed down to 50 degrees N and somewhat below, a region not accessible to previous FOC observations at longer wavelengths. Temporal variations are also observed on timescales of hours to days. [less ▲]

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See detailThe inducible 70,000 molecular/weight heat shock protein is expressed in the degenerating dentate hilus and piriform cortex after systemic administration of kainic acid in the rat.
Armstrong, J. N.; Plumier, Jean-Christophe ULg; Robertson, H. A. et al

in Neuroscience (1996), 74(3), 685-93

Using both immunohistochemistry and in situ hybridization, we examined the rat brain for the expression of the inducible 70,000 mol. wt heat shock protein, Hsp70, at 3,6,12 and 24 h after systemic ... [more ▼]

Using both immunohistochemistry and in situ hybridization, we examined the rat brain for the expression of the inducible 70,000 mol. wt heat shock protein, Hsp70, at 3,6,12 and 24 h after systemic administration of kainic acid. In contrast to previous reports, the present study demonstrates that neurons in the regions most susceptible to seizure-induced cell death accumulate both Hsp70 messenger RNA and protein. Neurons in the denate hilus and piriform cortex contained Hsp70 messenger RNA at 6 h and protein at 12 h. These neutrons contained little or no Hsp70 messenger RNA or protein at 24 h when the majority of cells in these area were pyknotic. Injured neurons in areas such as the parietal cortex, which are less susceptible to seizure-induced cell death, expressed and maintained high levels of Hsp70 messenger RNA and protein at 12 and 24 h. This work suggest that Hsp70 messenger RNA and protein are rapidly and transiently expressed in dying neurons, and contradicts the notion that Hsp70 only accumulates in injured neurons that survive. [less ▲]

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See detailThe Potent Angioinhibin Agm-1470 Stimulates Normal but Not Human Tumoral Lymphocytes
Antoine, Nadine ULg; Daukandt, M.; Locigno, R. et al

in Tumori (1996), 82(1, Jan-Feb), 27-30

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects ... [more ▼]

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects have already led to phase I clinical trials in patients with solid cancers. However, neither the exact mechanisms of action of AGM-1470 nor its effects on the host of normal cells have been extensively studied. Recently, we showed that AGM-1470 enhanced the proliferation of B lymphocytes in the presence of T cells. Since AGM-1470 could potentially be used in patients with lymphoma, it was urgent to test the effect of the molecule on the proliferation of tumor lymphocytes. METHODS: The possible effect of AGM-1470 on the proliferation of normal or tumor lymphocytes was evaluated by thymidine-incorporated assays. Normal T and B lymphocytes were purified from human tonsils. The tumor lymphocytes used in the study were Molt 3, Molt 4 and Jurkatt cell lines for the T lineage and Daudi and Radji cell lines for the B lineage. RESULTS: As shown previously, AGM-1470 stimulates the proliferation of normal B lymphocytes through an action on normal T cells. THe angioinhibin was ineffective ont eh proliferation of both T and B transformed cells. Moreover, in the presence of the drug, tumor T cells co-cultured with normal B lymphocytes did not induce any increase in B cell proliferation, as previously observed with normal T lymphocytes. Inversely, tumor B cells co-cultured with normal T lymphocytes were insensitive to the drug. CONCLUSIONS: Our results demonstrate that AGM-1470 is ineffective on lymphoid tumor cell proliferation and could potentially be safely administered to lymphoma patients. [less ▲]

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See detailComparison of some modules of the Lie algebra of vector fields
Lecomte, Pierre ULg; Mathonet, Pierre ULg; Tousset, E.

in Indagationes Mathematicae (1996), 7(4), 461-471

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See detailLifetimes of the 3d2D levels in Ca II
Biémont, Emile ULg; Zeippen, C. J.

in Comments on Atomic and Molecular Physics (1996), 33

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See detailStrategic directions in concurrency research
Cleaveland, R.; Smolka, S. A.; Alur, R. et al

in ACM Computing Surveys (1996), 28(4), 607-625

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See detailMutations structurelles d'emploi et insertion professionnelle
Gavray, Claire ULg

in Lettre d'information TEF (1996), 4

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See detailRadiative Lifetimes for States in Cu I
Biémont, Emile ULg; Fryczynski, F.; Palmeri, P. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (1996), 55

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See detailL'efficacité des services publics
Perelman, Sergio ULg

in Revue Française de Finances Publiques (1996), (55), 65-79

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See detailNéphropathie tubulo-interstitielle aigue avec uvéite: à propos d'un cas
Weber, T.; Beckers, C.; Kaye, O. et al

in Acta Clinica Belgica (1996), 51(1), 53-56

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment ... [more ▼]

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment needed to reach the diagnosis. The evolution is unusually favourable with steroid therapy. [less ▲]

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See detailExperimental model for the study by chemiluminescence of the activation of isolated equine leucocytes.
Benbarek, H.; Deby, Ginette ULg; Deby, C. et al

in Research in Veterinary Science (1996), 61(1), 59-64

The activation of human polymorphonuclear leucocytes (the respiratory burst) can be studied by measuring their chemiluminescent response. This technique was adapted to equine leucocytes to investigate the ... [more ▼]

The activation of human polymorphonuclear leucocytes (the respiratory burst) can be studied by measuring their chemiluminescent response. This technique was adapted to equine leucocytes to investigate the effects of cell number, activator concentration, enhancers of chemiluminescence, pH, temperature and inhibitors. Leucocytes were isolated from citrated blood from healthy horses and chemiluminescence was measured with a Bio-Orbit luminometer sensitive to 900 nm light. The optimal cell density for the maximal chemiluminescent response ranged from 10(6) to 10(7) leucocytes 600 microliters-1. Chemiluminescence increased as a function of temperature, and the concentrations of luminol, lucigenin and phorbol myristate acetate (PMA), and was pH related (optimal pH value = 8.0 for lucigenin and 8.5 for luminol). The inhibition of chemiluminescence by 5 x 10(-5) M azide was 88 per cent for luminol and 37 per cent for lucigenin. Superoxide dismutase (100 IU) totally inhibited the chemiluminescence response. Approximately 30 per cent variability in chemiluminescence was observed under the same assay conditions, depending on the origin of the leucocytes. Based on these results, the conditions selected for the measurement of equine leucocyte chemiluminescence were: 10(6) to 10(7) leucocytes 600 microliters-1, 1 x 10(-6)M PMA, 1 mM luminol or 0.4 mM lucigenin, physiological pH (7.4) and physiological temperature (37.8 degrees C). These conditions were similar to those used for measuring the chemiluminescent response of human leucocytes. [less ▲]

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See detailCan Motor Recovery in Stroke Patients Be Predicted by Early Transcranial Magnetic Stimulation ?
Rapisarda, Giuseppe; Bastings, Eric; MAERTENS DE NOORDHOUT, Alain ULg et al

in Stroke (1996), 27(12), 2191-2196

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See detailMortality in Oryzaephilus surinamensis following short-term exposure to conditioned kernels by high-density culture
Mignon, Jacques ULg; Haubruge, Eric ULg; Lienard, Valérie et al

in Entomologia Experimentalis et Applicata (1996), 80(3), 555-557

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See detailLocalisation respiratoire d'un lymphosarcome cutané chez un cheval.
Anciaux, Nathalie; Amory, Hélène ULg

in Pratique Vétérinaire Equine (1996), 28

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See detailThe holodisc distance transform and its applications in image analysis
Pirard, Eric ULg

in Microscopy, Microanalysis, Microstructures (1996), 7

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See detailMiospore ranges near the D/C Boundary and extinction events.
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (1996), 12

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See detailHeat shock-induced myocardial protection against ischemic injury: a role for Hsp70?
Plumier, Jean-Christophe ULg; Currie, R. W.

in Cell Stress & Chaperones (1996), 1(1), 13-7

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See detailRecommendations for the registration of agents used in the prevention and treatment of glucocorticoid-induced osteoporosis
Compston, JE; Audran, M; Avouac, B et al

in Calcified Tissue International (1996), 59

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See detailPrognostic Significance of bcl-2 Protein Expression in Aggressive Non-Hodkin's Lymphoma
Hermine, Olivier; Haioun, Corinne; Lepage, Eric et al

in Blood (1996)

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See detailTribology in Aerospace Propulsion Mechanisms
Bozet, Jean-Luc ULg

in Space Scientific Research in Belgium, vol. IV : Space Technology (1996), 4

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See detailMise au point medicale avant gastroplastie: indications et contre-indications.
Scheen, André ULg

in Revue Médicale de Bruxelles (1996), 17(4), 232-5

Because of the common failure of the various medical procedures used for the treatment of morbid obesity, surgeons have searched alternatives among which gastroplasty appears to offer now the best ... [more ▼]

Because of the common failure of the various medical procedures used for the treatment of morbid obesity, surgeons have searched alternatives among which gastroplasty appears to offer now the best efficacy/safety ratio. Such approach has become more and more popular in our country, but success is almost highly variable from patient to patient. A careful medical assessment is necessary before performing gastroplasty. It mainly aims at choosing the appropriate indications (failure of previous well-applied medical therapy, exclusion of any hormonal cause of obesity, presence of complications due to weight excess, ...) and at excluding cardiovascular (unstable coronaropathy, carotid stenosis, ...), digestive (recurrent oesophagitis, ...) or psychiatric contra-indications. Such medical assessment before gastroplasty should allow to increase the success rate and to reduce the incidence of complications after the surgical procedure. [less ▲]

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See detailA comprehensive pollen- and tephra- based chronostratigraphic model for the Late Glacial and Holocene Period in the French Massif Central.
Juvigné, Etienne ULg; Bastin, B; Delibrias, G et al

in Quaternary International (1996), 34-36

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See detailPerforation Strength of Geosynthetics and Sphericity of Coarse Grains: a new approach
Courard, Luc ULg; Antoine, R.

in Geotextiles & Geomembranes (1996), 14

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See detailBenard-Marangoni instability in rigid rectangular containers
Dauby, Pierre ULg; Lebon, Georgy ULg

in Journal of Fluid Mechanics (1996), 329

Not Available

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See detailHeparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells.
Incardona, F.; Lawler, J.; Cataldo, Didier ULg et al

in Journal of Cellular Biochemistry (1996), 62(4), 431-42

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains ... [more ▼]

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains of thrombospondin that mediate its binding to specific receptors on the human breast adenocarcinoma cell line, MDA-MB-231. Two recombinant fragments from the amino-terminus (TSPN18 and TSPN28), and the fusion proteins of the type 1 and type 2 repeats of human thrombospondin, inhibited binding of radiolabeled thrombospondin to MDA-MB-231 cells in suspension by 40-60% at 50 micrograms/ml whereas the type 3 repeat, carboxy-terminus and unfused glutathione-S-transferase as well as the synthetic peptide Gly-Arg-Gly-Asp-Ser (500 micrograms/ml) had little or no effect. Heparin and various glycosaminoglycans as heparan sulfate, chondroitin sulfates A, B or C, and fucoidan inhibited thrombospondin binding to MDA-MB-231 cells by more than 60% whereas dextran sulfate had only little effect. Treatment of cells with heparitinase, chondroitinase ABC, and hyaluronidase, but not with neuraminidase, induced 30-50% inhibition of thrombospondin binding suggesting the participation of both heparan sulfate and chondroitin sulfate cell surface-associated molecules. Inhibition of proteoglycan sulfation by chlorate or inhibition of glycosaminoglycan chain formation by two beta-D-xylosides also led to a substantial inhibition of thrombospondin binding. Our results indicate that several domains within the thrombospondin molecule, namely the amino-terminus, type 1 and type 2 repeats, participate in its binding to specific receptors bearing sulfated glycosaminoglycans on MDA-MB-231 cells. Biological assays have indicated that, in addition to these domains, the peptide Gly-Arg-Gly-Asp-Ser inhibited MDA-MB-231 cell attachment to thrombospondin suggesting that the last type 3 repeat of the molecule may also contribute to its cell adhesive activity. [less ▲]

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See detailHigh neuron specific enolase levels in bronchoalveolar lavage fluid of patients with lung carcinoma: diagnostic value, relation to serum neuron specific enolase, and staging.
Dowlati, A; Bury, Thierry ULg; CORHAY, Jean-Louis ULg et al

in Cancer (1996), 77(10), 2039-43

BACKGROUND: High levels of neuron specific enolase (NSE) have recently been described in the bronchoalveolar lavage (BAL) fluid of patients with lung carcinoma. Although its value in serum has been ... [more ▼]

BACKGROUND: High levels of neuron specific enolase (NSE) have recently been described in the bronchoalveolar lavage (BAL) fluid of patients with lung carcinoma. Although its value in serum has been extensively studied, its diagnostic value in BAL fluid in terms of sensitivity, specificity, and predictive value have not been evaluated. In addition, its value in staging and relation to serum NSE are yet unknown. METHODS: NSE levels were determined on the same day in the BAL fluid and the sera of two groups of patients: those with newly diagnosed lung carcinoma and those with smoking related chronic obstructive pulmonary disease (COPD). Clinical TNM staging was also performed. Levels of NSE in BAL fluid were expressed as nanograms per 100 international units of lactate dehydrogenase. BAL fluid NSE levels of the two groups were compared with staging and serum NSE. RESULTS: A highly significant difference exists in BAL NSE in the two groups. For diagnostic purposes, the simultaneous measurements of serum NSE increases its sensitivity, but specificity remains unchanged. No correlation exists between BAL NSE and serum NSE, tumor size, nodal status, or the presence of metastases. BAL NSE is a better predictor of malignancy than serum NSE. CONCLUSION: BAL fluid measurements of NSE may have diagnostic value, specially if it is simultaneously measured in the serum. However, our study does not show any value for this technique in staging of lung carcinoma. Also it has no correlation with serum NSE. Studies will have to be performed to determine if BAL NSE can predict chemotherapeutic sensitivity. [less ▲]

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See detailBiogeography and taxonomy of Apodemus sylvaticus (the woodmouse) in the Tyrrhenian region: Enzymatic variations and mitochondrial DNA restriction pattern analysis
Michaux, Johan ULg; Filippucci, M. G.; Libois, Roland ULg et al

in Heredity (1996), 76(Part 3), 267-277

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown ... [more ▼]

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown in geographical terms. In order to examine the level of genetic relatedness of insular and continental woodmice, 258 animals were caught in 24 localities distributed in Belgium, France, mainland Italy, Sardinia, Corsica and Elba. Electrophoresis of 33 allozymes and mtDNA restriction fragments were performed and a UPGMA dendrogram built from the indices of genetic divergence. The dendrogram based on restriction patterns shows two main groups: 'Tyrrhenian', comprising all the Italian and Corsican animals and 'North-western', corresponding to all the other mice trapped from the Pyrenees to Belgium. Since all the Tyrrhenian mice are similar and well isolated from their relatives living on the western edge of the Alpine chain, they must share a common origin. The insular populations are consequently derived from peninsular Italian ones. From a taxonomic point of view and taking the priority rules into account, we have to invalidate A. s. clanceyi Harrison, 1948 and to consider the Tyrrhenian woodmice as belonging to A. s. milleri de Beaux, 1926, whereas the North-western ones must be referred to as the nominal subspecies. As far as the Elban woodmouse is concerned, at the moment we prefer to keep its present subspecific status because we only studied one animal. [less ▲]

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See detailTransition probabilities for forbidden lines of Fe III
Quinet, Pascal ULg

in Astronomy and Astrophysics. Supplement Series (1996), 116

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See detailUsefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study.
Daubresse, Jean-Claude; Kolanowski, J.; Krzentowski, G. et al

in Obesity Research (1996), 4(4), 391-6

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent ... [more ▼]

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent diabetics, moderately obese (BMI = 30 - 39 kg/m2), were given for an 8-week period either placebo (P) or fluoxetine (F), a specific serotonin reuptake inhibitor, in addition to their usual antidiabetic treatment. Thirty-nine of them received 60 mg fluoxetine a day and 43 were given the placebo. At admission, both groups had similar weight excess, metabolic control and serum lipid values. In comparison with the P-treated subjects, those treated with fluoxetine (F) lost more weight after 3 weeks (-1.9 vs. -0.7 kg, p < -0.0009) and after 8 weeks (-3.1 vs. -0.9 kg, p < 0.0007). Fasting blood glucose decreased in group F after 3 weeks (-1.5 vs -0.4 mmol/L, p < 0.003) and after 8 weeks (-1.7 vs. -0.02 mmol/L, p < 0.0004). HbAlc decreased from 8.5% to 7.7% in group F and from 8.6% to 8.3% in group P (p = 0.057). Mean triglyceride level was also reduced in group F after 8 weeks (p = 0.042). Fasting C-peptide did not change in either group, but fasting insulin values decreased in group F after 3 weeks (p < 0.02) and after 8 weeks (p < 0.05). The insulin/C-peptide molar ratio decreased significantly in group F after 3 weeks (p < 0.04) and after 8 weeks (p < 0.05) in comparison with group P. The drug was generally well tolerated and no major side effects were reported. In conclusion, the addition of fluoxetine to the usual oral hypoglycemic agent therapy might be beneficial in obese non-insulin-dependent diabetics, at least on a short-term basis. [less ▲]

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See detailLigniculture et maintien de la fertilité des sols dans l'Ouest-Cameroun
Njoukam, Raphaël; Bock, Laurent ULg; Hebert, Jacques ULg et al

in Bois et Forêts des Tropiques (1996), (249), 33-49

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See detailL’éducation géographique. Pour une vision citoyenne du monde
Merenne-Schoumaker, Bernadette ULg

in Géographes Associés (1996), (19), 65-69

Brief reflection on the place of the teaching of geography in education for citizenship

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See detailModelling the competition between two phytoplanktonic species
Elkafazi, Abderahman; Djenidi, Salim ULg; Nihoul, Jacques ULg

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailUna Cabeza Bien Hecha O Una Cabeza Repleta ?
Crahay, Marcel ULg

in Perspectivas (1996), XXVI(1),

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See detailMaladie pulmonaire obstructive chronique dans l'espèce équine
Vandenput, Sandrina ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Equine chronic obstructive pulmonary disease (COPD), also known as <<heaves>>, is a respiratory syndrome associated with stabling or exposure to hay or conditions in which molds or dust prevail. This ... [more ▼]

Equine chronic obstructive pulmonary disease (COPD), also known as <<heaves>>, is a respiratory syndrome associated with stabling or exposure to hay or conditions in which molds or dust prevail. This paper reviews the different aspects of the equine COPD. Etiology, potential evolutions, treatment and prevention of this disease are evolved. [less ▲]

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See detailSeasonal temperature and salinity fields in the Mediterranean Sea: Climatological analyses of a historical data set
Brasseur, P.; Beckers, Jean-Marie ULg; Brankart, J. M. et al

in Deep-Sea Research Part I, Oceanographic Research Papers (1996), 43(2), 159-192

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly ... [more ▼]

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly distributions of hydrographic properties have been computed by a variational inverse method as an alternate to the standard Gandin (1969; Objective analysis of meterological fields, Israeli Program for Scientific Translation, Jerusalem) procedure. The spline solutions of the minimization problem are demonstrated to be numerically and theoretically equivalent to field estimates obtained by conventional objective analysis. The application of a finite-element technique allows analysis to be performed in the model space rather than in the observational space, which substantially improves the numerical efficiency of the procedure. The parameters of the scheme are adjusted according to the statistics of the climatological data. The results,realized as gridded data sets (horizontal resolution of 0.25 degrees), show some trends in seasonal variability affecting the properties of water masses. As expected, the upper layer is subject to a well-defined seasonal signal affecting both the temperature and salinity fields. Error maps, reflecting the degree of uncertainty in the analyses, have been systematically produced. The present work is conceived as a basic support to more advanced studies such as diagnostic calculations, initialization of dynamical models, assimilation of hydrological data into primitive equation models, or planning of experimental surveys. New versions of the climatological fields will be released as data are added to the historical data base. Copyright (C) 1996 Elsevier Science Ltd. [less ▲]

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See detailCloning, sequencing and overexpression in Escherichia coli of the alginate lyase-encoding aly gene of Pseudomonas alginovora: identification of three classes of alginate lyases
Chavagnat, Frederic; Duez, Colette ULg; Guinand, Micheline et al

in Biochemical Journal (1996), 319(Pt 2), 575-583

A gene of Pseudomonas alginovora, called aly, has been cloned in Escherichia coli using a battery of PCR techniques and sequenced. It encodes a 210-amino-acid alginate lyase (EC 4.2.2.3), Aly, in the form ... [more ▼]

A gene of Pseudomonas alginovora, called aly, has been cloned in Escherichia coli using a battery of PCR techniques and sequenced. It encodes a 210-amino-acid alginate lyase (EC 4.2.2.3), Aly, in the form of a 233-amino-acid precursor. P. alginovora Aly has been overproduced in E. coli with a His-tag sequence fused at the C-terminal end under conditions in which the formation of inclusion bodies is avoided. His-tagged P. alginovora Aly has the same enzymic properties as the wild-type enzyme and has the specificity of a mannuronate lyase. It can be purified in a one-step procedure by affinity chromatography on Ni(2+)-nitriloacetate resin. The yield is of 5 mg of enzyme per litre of culture. The amplification factor is 12.5 compared with the level of production by wild-type P. alginovora. The six alginate lyases of known primary structure fall into three distinct classes, one of which comprises the pair P. alginovora Aly and Klebsiella pneumoniae Aly. [less ▲]

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See detailThe Ovine Callipyge Locus: A Paradigm Illustrating the Importance of Non-Mendelian Genetics in Livestock
Georges, Michel ULg; Cockett, N.

in Reproduction Nutrition Development (1996), 36(6), 651-7

An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge (CLPG) gene mapped to ovine chromosome 18. We demonstrate in this work that the callipyge ... [more ▼]

An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge (CLPG) gene mapped to ovine chromosome 18. We demonstrate in this work that the callipyge phenotype is characterized by a non-Mendelian inheritance pattern, referred to as polar overdominance, in which only heterozygous individuals having inherited the CLPG mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged. [less ▲]

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See detailStorm surges in the Arabian/Persian Gulf
Djenidi, Salim ULg; Neuberg, Luc

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailEvaluation de l'effet apaisant d'un dermocosmétique: Soin intense apaisant
Nikkels, Arjen ULg; Jacquet, A.; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1996), 15

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation ... [more ▼]

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation and sites chromametry) and indirect investigations (corneocyte harvesting and chromametric analysis) have been conducted. The excellent correlation between the results has lead us to prove a very obvious soothing effect of SOIN INTENSE APAISANT (care range Hydrocapteur of Castalia, Laboratoires Lavipharm). [less ▲]

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See detailA systematic view on medical informatics.
Hasman, A; Haux, R; Albert, Adelin ULg

in Computer Methods & Programs in Biomedicine (1996), 51(3), 131-9

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics ... [more ▼]

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics (including health informatics), its aim, methods and tools, and its relevance to other disciplines in medicine and health sciences are outlined. It is recognized that one of the major tasks of medical informatics is modelling processes. In this context, biological, communication, decision, engineering, educational, organizational and computational processes are distinguished and described. [less ▲]

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See detailDiagnostico del sindrome del canal carpiano en el caballo: 6 casos clinicos
Denoix, Jean-Marie; Romero, Antonio; Vàzquez, Francisco J et al

in Medicina Veterinaria (1996), 13

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See detailIsolation of nucleoli from ELT cells: a quick new method that preserves morphological integrity and high transcriptional activity.
Vandelaer, M.; Thiry, Marc ULg; Goessens, Guy ULg

in Experimental Cell Research (1996), 228(1), 125-31

We have developed a quick new method for isolating nucleoli which, unlike the methods in current use, preserves the nucleolar ultrastructure. Until now, the isolation process has generally been assumed to ... [more ▼]

We have developed a quick new method for isolating nucleoli which, unlike the methods in current use, preserves the nucleolar ultrastructure. Until now, the isolation process has generally been assumed to empty one of the three major compartments of the nucleolus, the fibrillar center, of its content. We have used the AgNOR staining and in vitro transcription assay to test the degree of structural and functional preservation of the isolated nucleoli. Our results demonstrate the value of our procedure as a reliable tool for biochemical and ultrastructural studies on the nucleolus. Moreover, these proprieties prompt us to investigate the rRNA synthesis, using a nonisotopic approach, within morphologically intact isolated nucleoli. Thus, we show that newly synthesized rRNA transcripts are located not only in the dense fibrillar component, but also indubitably in the fibrillar center. [less ▲]

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See detailLa dérivée schwarzienne
Bair, Jacques ULg; Haesbroeck, Gentiane ULg

in Mathématique et Pédagogie (1996), 108

Dans cette note est introduit le concept de dérivée schwarzienne pour une fonction réelle univariée. Diverses propriétés et applications sont également proposées.

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See detailActivités sportives et système immunitaire
PIRNAY, Freddy ULg; Bury, Thierry ULg

in Médecine et Hygiène (1996), 54

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See detailRelationships between sleep quality and glucose regulation in normal humans.
Scheen, André ULg; Byrne, M. M.; Plat, L. et al

in American Journal of Physiology (1996), 271(2 Pt 1), 261-70

To define the effects of sleep on glucose regulation, we analyzed plasma glucose levels, insulin secretion rates (ISR), and plasma growth hormone and cortisol levels in normal subjects receiving a ... [more ▼]

To define the effects of sleep on glucose regulation, we analyzed plasma glucose levels, insulin secretion rates (ISR), and plasma growth hormone and cortisol levels in normal subjects receiving a constant glucose infusion during nocturnal sleep, nocturnal sleep deprivation, and daytime recovery sleep. Plasma glucose and ISR markedly increased during early nocturnal sleep and returned to presleep levels during late sleep. These changes in glucose and ISR appeared to reflect the predominance of slow-wave (SW) stages in early sleep and of rapid-eye-movement and wake stages in late sleep. Major differences in glucose and ISR profiles were observed during sleep deprivation as glucose and ISR remained essentially stable during the first part of the night and then decreased significantly, despite the persistence of bed rest and constant glucose infusion. During daytime recovery sleep, SW stages were increased, glucose levels peaked earlier than during nocturnal sleep, and the decreases of glucose and ISR in late sleep were reduced by one-half. Thus sleep has important effects on brain and tissue glucose utilization, suggesting that sleep disturbances may adversely affect glucose tolerance. [less ▲]

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See detailInfluence des facteurs individuels et de troupeau sur les performances de reproduction bovine
Hanzen, Christian ULg; Houtain, J. Y.; Laurent, Y. et al

in Annales de Médecine Vétérinaire (1996), 140

Through a wide review of the litterature (330 references), the authors have tried to describe the determinant or predisposing effects of factors usually involved in the reproduction problems in beef or ... [more ▼]

Through a wide review of the litterature (330 references), the authors have tried to describe the determinant or predisposing effects of factors usually involved in the reproduction problems in beef or dairy cattle. These factors have been qualified as individual or herd factors. The first ones involve the animal itself like age, genetic, milk production level, dystocia, twinning, perinatal mortality, placental retentio, milk fever, uterine involution, metritis, post-partum ovarian activity. The second ones concern the environnement of the animal i.e. first insemination policy, oestrus detection, insemination time and technic, nutrition, season, stabulation, herd size or management capacity of the farmer. The authors conclude to the multifactorial etiology of the reproduction pathologies. It also appears necessary to develop data collection systems like herd health management programs. Such systems should be able to offer to the practitionner the opportunity to be involved more efficiently in the economic health of the herd using epidemiological tools to study the different implied factors. [less ▲]

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See detailPréventeurs de tous les pays, unissez-vous
Lemaître, André ULg

in Revue de Droit Pénal et de Criminologie (1996), 7-8

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See detailMutation analysis of the pyruvate dehydrogenase E1 alpha gene in eight patients with a pyruvate dehydrogenase complex deficiency.
Lissens, W.; De Meirleir, L.; Seneca, S. et al

in Human mutation (1996), 7(1), 46-51

Most of the mutations causing deficiency of the pyruvate dehydrogenase (PDH) complex are in the X-linked E1 alpha gene. We have developed a rapid screening method for the detection of mutations in this ... [more ▼]

Most of the mutations causing deficiency of the pyruvate dehydrogenase (PDH) complex are in the X-linked E1 alpha gene. We have developed a rapid screening method for the detection of mutations in this gene using reverse transcription of total RNA, polymerase chain reaction amplification of the whole coding region of the gene and single-strand conformation polymorphism (SSCP) analysis. With this method, we studied eight patients with a PDH complex deficiency, using cultured fibroblasts. In all patients, aberrant SSCP patterns were found and, after sequencing of the corresponding fragments, we were able to identify six new mutations and two mutations already described previously. The mutations are point mutations leading to amino acid substitutions (5) and direct repeat insertions (3). The presence of the mutations was confirmed in genomic fibroblast DNA. The 4 female patients were shown to carry both a normal and a mutated E1 alpha gene. [less ▲]

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See detailNeonatal inhibition of brain estrogen synthesis alters adult neural Fos responses to mating and pheromonal stimulation in the male rat.
Bakker, Julie ULg; Baum, M. J.; Slob, A. K.

in Neuroscience (1996), 74(1), 251-60

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and ... [more ▼]

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vomeronasal projection circuit, which responds to reproductively relevant pheromonal cues. The medial preoptic area also receives genital somatosensory inputs via the midbrain central tegmental field and the medial amygdala. We used Fos immunoreactivity as a marker of neuronal activation to determine whether there is a correspondence between the behavioral profiles of neonatally ATD-treated male rats and their neuronal responses in the medial preoptic area and other brain regions to somatosensory and chemosensory stimuli. Achieving eight intromissions with an estrous female led to a greater neuronal Fos immunoreactivity in the medial preoptic area of neonatally ATD-treated male rats compared with neonatally cholesterol-treated male rats. Exposure for 1.5 h to chemosensory cues derived from soiled bedding of estrous females induced Fos immunoreactivity throughout the vomeronasal pathway (i.e. medial amygdala, bed nucleus of the stria terminalis and medial preoptic area) in both ATD and cholesterol males (Experiment 2a). By contrast, exposure for 1.5 h to chemosensory cues derived from soiled bedding of sexually active males revealed clear differences between ATD and cholesterol males in neuronal Fos immunoreactive (Experiment 2b). At peripheral portions of the vomeronasal pathway (i.e. the accessory olfactory bulb and the medial amygdala), there were no differences in the number of Fos immunoreactivity neurons between ATD and cholesterol males. However, neurons in the more central portions of the vomeronasal pathway (i.e. the bed nucleus of the stria terminalis and the medial preoptic area) showed increased Fos immunoreactivity after exposure to odors from sexually active males in ATD males as opposed to cholesterol males. Females, like ATD males, showed neuronal Fos immunoreactivity at each level of the vomeronasal pathway after being exposed to odors from sexually active males. These results suggest that the responsiveness of neurons in the central portion of the vomeronasal projection circuit to odors from sexually active males, but not estrous females, is sexually differentiated in male rats due to the neonatal action of estrogens. [less ▲]

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See detailCalcitonin
Reginster, Jean-Yves ULg

in Current Opinion in Orthopaedics (1996), 7

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See detailCase management voor psychogeriatrishe patiënten: gezondheidstoestand van deze ouderen en de zorgbelasting van hun centrale verzorgers
Milisen, K.; Borgermans, L.; Dejace, Alain ULg et al

in Acta Hospitalia (1996), 4

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See detailDe la phrase au texte dans l'enseignement d'une langue étrangère
Defays, Jean-Marc ULg

in Dialogues et cultures (1996), 40

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See detailAn investigation of the effects of daily physical education in kindergarten and elementary schools
Piéron, Maurice ULg; Cloes, Marc ULg; Delfosse, Catherine et al

in European Physical Education Review (1996), 2(2), 116-132

The project used different methods of data collection: tests, questionnaires and systematic observation of pupils and teachers. In developing a multiple viewpoint approach, we attenpted to sketch a ... [more ▼]

The project used different methods of data collection: tests, questionnaires and systematic observation of pupils and teachers. In developing a multiple viewpoint approach, we attenpted to sketch a detached view of the implementation of DPE and of tis results. Goals were as follows: (1) Exploring the possible effects of the programme in various areas of children's life that do not arise directly from their activities during physical education lessons. (2) Identifying children's school-life context, in order to identify factors influencing several effects of DPE. The various viewports considered, the results, and the knowledge of external variables all allowed us to identify a convergent package of indications, thus allowing us to think in terms of causality. Often, the benefits came from the children's involvement in the experimental programme. Improvements of motor performance in primary school age children arise from a maturation process and from practice and learning. Nevertheless, it is particularly hard to identify the relative contributions of these two sources. Tracing pupil's development, fro the starting level at beginning of the school year, appeared to allow isolation of the part played by children's activities whitin the school environement. In all grade levels, comparisons confirmed pilot classes superiority. Performances were significantly better in many tests. However, during the year, it seemed that the development of performance due to maturation masked the potential effects of physical activities. A decline in favourable attitudes was observed in every school at the beginning and the end of the school year. A slide from very favourable attitudes towards simply favourable attitudes was observed. ... [less ▲]

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See detailIncidence du martelage sur l'exploitation mécanisée des premières éclaircies résineuses
Hebert, Jacques ULg; Lejeune, Philippe ULg; Van Belle, Jean-François et al

in Silva Belgica (1996), 103(6), 7-14

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See detailFalls among the elderly: a community problem
Reginster, Jean-Yves ULg; Gosset, Christiane ULg; Reginster-Haneuse, G.

in Archives of Public Health (1996), 54

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See detailPremière approche de la flore macrolichénique corticole de la Région de Bruxelles-Capitale en situation de dépollution au SO2
Tanghe, Martin; Richel, Thierry; Crisan, Florin et al

in Belgian Journal of Botany (1996), 129

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See detailThe BFKL pomeron: Can it be detected?
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P. V.

in Nuclear Physics B (1996), 482

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See detailYounger age as a bad prognostic factor in patients with carcinoma of the cervix.
Delaloye, J-F; Pampallona, S; COUCKE, Philippe ULg et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (1996)

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre ... [more ▼]

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre Hospitalier Universitaire Vaudois of Lausanne were subdivided according to the following age categories: _<45, 46-60, 61-69 and > 70 years. Taking the 46-60 years age group as the reference, the hazard ratios (HR) of death and corresponding 95% confidence intervals (95% CI) were estimated by means of a Cox multivariate analysis. Results: The 5-year survival rates were, respectively, 57%, 67%, 60% and 45%. For the youngest women the risk of death was significantly increased (HR = 2.00, 95% CI [1.32-3.00]) and was even more accentuated in advanced stages. Conclusion: Age under 45 years is a bad prognostic factor in carcinoma of the cervix. [less ▲]

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See detailSequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals
Goffin, VINCENT; Shiverick, KATHLEEN T; Kelly, PAUL A et al

in Endocrine Reviews (1996), 17(4), 385-410

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See detailCalcium et squelette, base physiologique d’une prévention
Reginster, Jean-Yves ULg

in Les Nouvelles de Rhumatologie (1996), 1

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See detailDivorce et annulation du mariage simulé
Paris, Catherine ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1996)

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See detailThe lichen genus Lecanactis and allied genera in Papua New Guinea
Egea, J.M.; Sérusiaux, Emmanuël ULg; Torrente, Pilar

in Mycotaxon (1996), 59

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See detailTwo dimensional self-organized transitions for propagation in random media
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg; Cloots, Rudi ULg

in Czechoslovak Journal of Physics (1996), 46(Suppl. 4), 2277-2278

A simple so-called dynamic epidemic model, for the evolution of an advancing interface through a two-dimensional medium containing mobile impurities is investigated. A short range repulsion between the ... [more ▼]

A simple so-called dynamic epidemic model, for the evolution of an advancing interface through a two-dimensional medium containing mobile impurities is investigated. A short range repulsion between the front and the impurities leads to an aggregation process along the front, and to trapping of aggregates. The pattern of trapped impurities is found to be self-organized. The critical concentration of impurity for growth blocking on a square lattice is 0..56. The kinetics of this self-organization is analyzed and discussed. [less ▲]

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See detailL’ostéoporose en questions : plus dure sera la chute
Reginster, Jean-Yves ULg

in Stethoscopie Magazine (1996), 63

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See detailRelationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines
Creuven, Isabelle; Evrard, Christine ULg; Olivier, Anne et al

in Antiviral Research (1996), 30

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the ... [more ▼]

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the different affinity of the compounds for the herpes simplex virus type 1 (HSV-1) thymidine kinase. These compounds present a variable affinity according to the position of the heteroatom substituting the five-membered ring. An unfavourable substitution in the five-membered ring for interaction with the HSV-1 thymidine kinase has been identified. [less ▲]

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See detailIncidence et coûts sociaux directs de la fracture du fémur
Gillet, Pierre ULg; Reginster, Jean-Yves ULg

in Archives of Public Health (1996), 53(S1), 61

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See detailLa thermographie infrarouge dans l'étude de la thermorégulation chez le cheval : effets de l'entraînement
Ghafir, Y.; Art, Tatiana ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of ... [more ▼]

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of measurements of rectal and skin temperature. The results have shown a smaller increase of rectal temperature and a greater increase of cutaneous temperature following a training period of 6 weeks. They suggest an improvement of thermoregulation via the skin. [less ▲]

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See detailOscillator strengths for Ca-like iron, cobalt and nickel (Fe VII, Co VIII, Ni IX)
Quinet, Pascal ULg; Hansen, J E

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailA. Kastler (1902-1984)
Biémont, Emile ULg; Glansdorff, P.

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1996), 6e série(VII), 131-149

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See detailHeparin-coated Palmaz-Schatz stents in human coronary arteries. Early outcome of the Benestent-II Pilot Study.
Serruys, P. W.; Emanuelsson, H.; van der Giessen, W. et al

in Circulation (1996), 93(3), 412-22

BACKGROUND: The purpose of the Benestent-II Pilot Study was to evaluate the safety of delaying and eliminating anticoagulant therapy in patients receiving a heparin-coated stent in conjunction with ... [more ▼]

BACKGROUND: The purpose of the Benestent-II Pilot Study was to evaluate the safety of delaying and eliminating anticoagulant therapy in patients receiving a heparin-coated stent in conjunction with antiplatelet drugs. METHODS AND RESULTS: The study consisted of three initial phases (I, II, III) during which resumption of heparin therapy after sheath removal was progressively deferred by 6, 12, and 36 hours. In phase IV, coumadin and heparin were replaced by 250 mg ticlopidine and 100 mg aspirin. Of the 207 patients with stable angina pectoris and a de novo lesion in whom heparin-coated stent implantation was attempted, implantation was successful in 202 patients (98%). Stent thrombosis did not occur during all four phases, and the overall clinical success rate at discharge was 99%. Bleeding complications requiring blood transfusion or surgery fell from 7.9% in phase I to 5.9%, 4%, and 0% in the three following phases. Hospital stay was 7.4, 6.1, 7.2, and 3.1 days for the consecutive phases. The restenosis rate for the combined four phases was 13% (15% in phase I, 20% in phase II, 11% in phase III, and 6% in phase IV). The overall rate of reintervention for the four phases was 8.9%. At 6 months, 84%, 75%, 94%, and 92% of the patients of phases I to IV, respectively, were event free. For the four phases, the event-free rate was 86%, which compares favorably with the rate observed in the Benestent-I study (80%; relative risk, 0.68 [0.45 to 1.04]). CONCLUSIONS: The implantation of stents coated with polyamine and end-point-attached heparin in stable patients with one significant de novo coronary lesion is well tolerated, is associated with no (sub)acute stent thrombosis, and results in a favorable event-free survival after 6 months. [less ▲]

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See detailComposition of the essential oil of Piper acutifolium Ruiz. and Pav. from Peru.
Lognay, Georges ULg; Bouxin, P.; Marlier, M. et al

in Journal of Essential Oil Research (1996), 8(6),

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See detailCrystallization and preliminary X-ray diffraction studies of a-amylase from the antarctic psychrophile Alteromonas haloplanctis A23
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (1996), 5(10), 2128-2129

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the ... [more ▼]

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the molecular basis of cold adaptations, crystallographic studies of this cold-adapted enzyme have been initiated because a three-dimensional structure of a mesophilic counterpart, pig pancreatic alpha-amylase, already exists. alpha-Amylase from A. haloplanctis, which shares 53% sequence identity with pig pancreatic alpha-amylase, has been crystallized and data to 1.85 A have been collected. The space group is found to be C222(1) with a = 71.40 A, b = 138.88 A, and c = 115.66 A. Until now, a three-dimensional structure of a psychrophilic enzyme is lacking. [less ▲]

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See detailLe diabete non insulinodependant: de la physiopathologie au traitement.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(7-9), 395-402402-5

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important ... [more ▼]

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important public health problem. This polygenic disease is often expressed late in life and its evolution is accelerated by environmental factors leading to obesity. It combines defects in both insulin secretion and insulin action, and such defects are present in various proportions according to the type of patient and the stage of the disease. Diet and physical activity recommendations are the basis of the treatment. Current pharmacological approaches aim at improving insulin secretion and/or insulin cellular action. After secondary failure to oral drugs, insulin therapy should be initiated, the patient becoming "insulin-requiring". A synergy should be searched in the combination of various therapeutic modalities in order to improve the glycaemic control. [less ▲]

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See detailPhénomènes karstiques en milieux non carbonatés. Etudes de cavités et problématique de leur développement au Niger Occidental
Willems, Luc ULg; Pouclet, André; Lenoir, François et al

in Zeitschrift für Geomorphologie (1996)

The study of several caves in siliceous formations belonging to the Precambrian basement and its Cenozoic sedimentary cover brings to the fore the importante of an underground drainage network in relation ... [more ▼]

The study of several caves in siliceous formations belonging to the Precambrian basement and its Cenozoic sedimentary cover brings to the fore the importante of an underground drainage network in relation with crustal fracturation. This network guides the waler transfer from the land surface to the depth and generates géomorphologic phenomena similar to those in calcareous areas. The study of caves in a siliceous environmemts shows the importance of solution phenomena in their formation and also in that of West Niger landscapes. Therfore, a general model of topographic evolution îs proposed. [less ▲]

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See detailLes reliques sur ordinateur
George, Philippe ULg

in Le médiéviste et l'ordinateur (1996)

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See detailThe development of a European questionnaire for quality of life in patients with vertebral osteoporosis
Lips, P; Agnusdei, D; Caulin, F et al

in Scandinavian Journal of Rheumatology (1996), 25(103), 84-85

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See detailActualités thérapeutiques dans la thrombocytémie essentielle
Hermanne, J.-P.; Tassin, F.; Beguin, Yves ULg et al

in Médecine et Hygiène (1996), 54

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of ... [more ▼]

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of thrombocythaemia is controversial. Since th relationship of thrombosis and hemorrhage to platelet counts is not demonstrated, ther is no clear inidcation for using drugs capable of lowering platelet counts in young asymptomatic subjects. However, treatment should be offered to patients with a definite high risk of major or life-threatening hemostatic complications. The present paper reviews the incidence and risk factors for thrombotic complications and the use of medications inhibiting platelet production. [less ▲]

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See detailA Non-Cofactor Role of Thiamine Derivatives in Excitable Cells?
Bettendorff, Lucien ULg

in Archives of Physiology & Biochemistry (1996), 104(6), 745-751

Thiamine diphosphate (TDP) is an important cofactor of pyruvate (PDH) and alpha-ketoglutarate (KGDH) dehydrogenases and transketolase. Thiamine deficiency leads to reversible and irreversible brain ... [more ▼]

Thiamine diphosphate (TDP) is an important cofactor of pyruvate (PDH) and alpha-ketoglutarate (KGDH) dehydrogenases and transketolase. Thiamine deficiency leads to reversible and irreversible brain lesions due to impaired oxidative metabolism. A specific non-cofactor role for thiamine has also been proposed in excitable cells and thiamine triphosphate (TTP) might be involved in the regulation of ion channels. Thiamine is taken up by neuroblastoma cells through a high affinity transporter. Inside the cells, it is rapidly phosphorylated to TDP. This high turnover TDP pool is the precursor for TTP. Most of the TDP however has a low turnover and is associated with PDH and KGDH in mitochondria. In excised inside-out patches from neuroblastoma cells, TTP, at a concentration of 1 microM, activates chloride channels of large unitary conductance, the so-called maxi-Cl- channels. These channels are inhibited by oxythiamine from the outide. In addition to the role of TTP in the regulation of chloride channels, thiamine itself, or a presently unknown analog, may have trophic effects on neuronal cells. [less ▲]

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See detailProduction, automatic delivery and bolus injection of O-15 water for positron emission tomography studies
VanNaemen, John; Monclus, Michel; Damhaut, Philippe et al

in Nuclear Medicine and Biology (1996), 23(4), 413-416

An automatic system allowing repetitive bolus injection of oxygen-15-labeled water for PET studies is described in this report. The production of this radiopharmaceutical by the 16O(p,pn)15O nuclear ... [more ▼]

An automatic system allowing repetitive bolus injection of oxygen-15-labeled water for PET studies is described in this report. The production of this radiopharmaceutical by the 16O(p,pn)15O nuclear reaction on H216O, its purification and delivery nearby the PET camera, the injection system, and the quality controls are presented. [less ▲]

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See detailOne-pot enzymatic synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc sequence with in situ UDP-Gal regeneration.
Hokke, Cornelis H; Zervosen, Astrid ULg; Elling, Lothar et al

in Glycoconjugate Journal (1996), 13(4), 687-92

The trisaccharide Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was enzymatically synthesized, with in situ UDP-Gal regeneration. By combination in one pot of only four enzymes, namely ... [more ▼]

The trisaccharide Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was enzymatically synthesized, with in situ UDP-Gal regeneration. By combination in one pot of only four enzymes, namely, sucrose synthase, UDP-Glc 4'-epimerase, UDP-Gal:GlcNAc beta 4-galactosyltransferase and UDP-Gal:Gal beta 1-->4GlcNAc alpha 3-galactosyltransferase, Gal alpha 1-->3Gal beta 1-->4GlcNAc beta 1-->O-(CH2)8COOCH3 was formed in a 2.2 mumol ml-1 yield starting from the acceptor GlcNAc beta 1-->O-(CH2)8COOCH3. This is an efficient and convenient method for the synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc epitope which pays an important role in various biological and immunological processes. [less ▲]

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See detailAstroglia-released factor with negative allosteric modulatory properties at the GABA A receptor.
Rigo, Jean-Michel; Belachew, Shibeshih ULg; Coucke, Paul et al

in Biochemical Pharmacology (1996), 52(3), 465-473

We have previously shown, using whole-cell patch-clamp techniques, that astrocytes release a negative allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor) with beta ... [more ▼]

We have previously shown, using whole-cell patch-clamp techniques, that astrocytes release a negative allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor) with beta-carboline-like properties, thus, likely to act at the benzodiazepine site. Here, using patch-clamp and binding techniques, we confirm that the low-molecular-weight fraction of astroglia-conditioned medium (ACM lmf) contains a factor(s) that negatively modulates GABAA-receptor function. This factor, like beta-carbolines, enhances the specific binding of [35S]t-butyl bicyclophosphorothionate (TBPS) to adult rat cortical membranes in the presence of GABA. However, it fails to interact with various ligands of the benzodiazepine (BZD) site of the GABAA receptor ([3H]flunitrazepam, [3H]Ro 15-1788 and [3H]Ro 15-4513). The question of the actual binding site of the astroglia-derived factor on the GABAA receptor, thus, remains open and can be addressed only after the purification of the active molecule(s) of ACM Imf has been completed, and a labeled form of the endogenous ligand becomes available. Taken together, however, the data suggest that type 1 astrocytes are able to modulate the effects of the main inhibitory neurotransmission in the central nervous system. [less ▲]

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See detail"Aquí, allá y en todas partes": La (con)version de la Identidad Caribeña por Michelle Cliff
Ledent, Bénédicte ULg; Ortega, María Teresa

in Anales del Caribe (1996), 16-18

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See detailObesity in children. Environmental and genetic Aspects
Guillaume, Michèle ULg; Bjorntorp, P.

in Hormone and Metabolic Research. Supplement Series (1996), 28

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See detailDeffand, Marie de Vichy-Chamrond, marquise du
Tilkin, Françoise ULg

in Voir barré (1996), 12-13

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See detailPersistency of lactation yields: A review
Gengler, Nicolas ULg

in Interbull Bulletin (1996), 12

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See detailChronic Exposure of Pigs to Airborne Dust and Endotoxins in an Environmental Chamber: Technical Note
Urbain, B.; Prouvost, J. F.; Beerens, Dominique ULg et al

in Veterinary Research (1996), 27(6), 569-578

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were ... [more ▼]

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were evaluated in a chamber containing two pigs of 10 kg body-weight: inhalable and respirable dust gravimetric concentrations were measured using area samplers and expressed as mg/m3. The respirable dust concentration was also measured using a "TM digital microP respirable dust-measuring instrument', which has been shown to give similar results to the gravimetric method. The endotoxin concentration was evaluated using the Limulus-assay and expressed as ng/m3 of air containing the inhalable or respirable dust or as ng/mg of inhalable and respirable dust. Feed flour dust was introduced into the chamber to obtain different concentrations of inhalable and respirable dust ranging from 3.62 to 76.66 mg/m3 and from 0.24 to 1.40 mg/m3, respectively. The endotoxin concentration was modulated by mixing the feed flour with Escherichia coli endotoxins before blowing it into the chamber. The endotoxin concentrations in the air containing inhalable or respirable dust ranged from 28.9 to 270.0 ng/m3 and from 2.22 to 36.38 ng/m3, respectively, depending on the amount of endotoxins added to the dust. Data were also obtained in a piggery. The experimental setup detailed in this paper could be used to study the significance of air contaminants in the development of pig respiratory diseases. [less ▲]

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See detailEnergy levels and oscillator strengths for transitions in Pd II
Quinet, Pascal ULg

in Physica Scripta (1996), 54

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See detailStromelysin-3 expression promotes tumor take in nude mice
Noël, Agnès ULg; Lefebvre, O.; Maquoi, Erik ULg et al

in Journal of Clinical Investigation (1996), 97

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer experiments using both anti-sense and sense ST3 expression vectors, and malignant cells either expressing (NIH 3T3 fibroblasts) or not (MCF7 epithelial cells) endogenous ST3. We have compared the ability of parental and transfected cells to cause subcutaneous tumor development in nude mice. 3T3 cells expressing anti-sense ST3 RNA showed reduced tumorigenicity, and MCF7 cells expressing mouse or human ST3 were associated with reduced tumor-free period leading to a significant increased tumor incidence(P<10(-4)). However, once established, the ST3 expressing tumors did not grow faster than those obtained with the parental MCF7 cell line. In addition, tumors obtained after sub-cutaneous injection of ST3-expressing or nonexpressing cells did not exhibit obvious histological differences, and careful examination did not reveal any local invasive tissue areas nor systemic metastases. These in vivo observations were in agreement with those obtained in vitro showing that ST3 expression did not modify proliferative nor invasive properties of transfected cells. Altogether, these results indicate that ST3 expression promotes tumor take in nude mice, presumably by favoring cancer cell survival in a tissue environment initially not permissive for tumor growth. These findings represent the first experimental evidence showing that ST3 can modulate cancer progression. [less ▲]

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See detailAn efficient procedure for the production of fatty acid hydroperoxides from hydrolyzed flax seed oil and soybean lipoxygenase.
Fauconnier, Marie-Laure ULg; Marlier, M.

in biotechnology techniques (1996), 10(11), 839-844

Production of 13-linolenic acid hydroperoxides Tom hydrolyzed flax seed oil using lipoxygenase extracted Tom soybean seedshas been achieved with high transformation yields (60 g.l.-1h-1) with a high ... [more ▼]

Production of 13-linolenic acid hydroperoxides Tom hydrolyzed flax seed oil using lipoxygenase extracted Tom soybean seedshas been achieved with high transformation yields (60 g.l.-1h-1) with a high purity (94 % of i3-isomers) in a 10 liter reactor without addition of any solvent or surfactant. The reaction limiting factor is, probably, the accessibility of the substrate to the enzyme. [less ▲]

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See detailContrefaçons liégeoises et maestrichtoises de Beaumarchais. Un exercice bibliographique
Droixhe, Daniel ULg

in Bulletin de l'Institut Archéologique Liégeois (1996), 107

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See detailModelling the North Sea hydrodynamics in a management perspective
Djenidi, Salim ULg; Delhez, Eric ULg; Martin, Géraldine ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailAntimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Wright, C. W.; Phillipson, J. D.; Awe, S. O. et al

in Phytotherapy Research (1996), 10

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar ... [more ▼]

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day. [less ▲]

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See detailImpact of the microbiology in the epuration processes.
Thonart, Philippe ULg; Destain, Jacqueline ULg; Antoine, Patrice et al

in Cerevisia and Biotechnology (1996), 21(2), 76-79

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at ... [more ▼]

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at very low concentrations of pollutants. Two approaches can be considered for developing biological processes of epuration : addition of bioactivators for improving endogenous microorganisms capabilities or introduction of microorganism starters for accelerating the epuration process. These two ways need as prerequisite a basic knowledge of the metabolic pathways for specific compound degradation and of microbial ecology [less ▲]

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See detailEvaluation of insuline-like growth horme-I (IGF-I) and their binding proteins (IGFBPs) in pigs
Renaville, Robert ULg; Prandi, Alberto; Claes, Victor et al

in Archivio Veterinario Italiano (1996), 46

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