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See detailThe hair eclipse phenomenon: sharpening the focus on the hair cycle chronobiology.
Pierard, Claudine ULiege; Petit, L.; Loussouarn, G. et al

in International Journal of Cosmetic Science (2003), 25(6), 295-9

Chronobiology governing the hair cycle is a fascinating and complex process. Both the hair growth cycle and the hair shaft growth are coordinated and depend on the interplay of different biological ... [more ▼]

Chronobiology governing the hair cycle is a fascinating and complex process. Both the hair growth cycle and the hair shaft growth are coordinated and depend on the interplay of different biological signals and various exogenous stimuli. A latency period may occur between hair shedding (teloptosis, exogen phase) and the early emergence of the next anagen VI stage. This lag time referred to on the hair eclipse phenomenon likely depends on the influence of a series of distinct synchronizers, and does not represent per se a peculiar hair cycle phase. It is the result of some dysregulations of the hair cycling, involving early teloptosis, delayed anagen I initiation or stunted hair growth at any stage between the anagen I and anagen V phases. As such, the hair eclipse phenomenon may be an erratic process occurring in physiopathological conditions affecting hair follicles singly or in focal to generalized patterns. It may be more frequent when it follows synchronized teloptosis occurring in telogen effluvium (newborn alopecia, post-partum alopecia, seasonal alopecia and alopecia areata). It may also be prominent when microinflammation is abutted on the permanent portion of the hair follicle as in dandruff, seborrhoeic dermatitis, androgenic alopecia and photoageing baldness. Local synchronizers such as growth factors and other mediators may eventually be lacking or involved in the hair eclipse phenomenon. Their identification and characterization might drive new corrective or preventive applications. [less ▲]

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See detailComment je traite ... une hypertrichose.
Pierard, Claudine ULiege; Henry, Frédérique ULiege; Paquet, Philippe ULiege et al

in Revue Médicale de Liège (2003), 58(10), 605-10

Hypertrichosis can result from various origins and exhibit diverse clinical presentations. Any etiological treatment, when available, does not always lead to regression of the excess in pilosity. Most ... [more ▼]

Hypertrichosis can result from various origins and exhibit diverse clinical presentations. Any etiological treatment, when available, does not always lead to regression of the excess in pilosity. Most often, hypertrichosis represents a real esthetic burden and affects the patient's self-esteem. Currently the laser epilation technique offers new and promising therapeutic possibilities. [less ▲]

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See detailPrediction of organoleptic and technological characteristics of pork meat by near infrared spectroscopy
Meulemans, A.; Dotreppe, Olivier ULiege; Leroy, Bernadette ULiege et al

in Sciences des Aliments (2003), 23(1), 159-162

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See detailEvaluation des risques biomécaniques pour la colonne lombaire au moyen d'un questionnaire
Somville, Pierre-René ULiege; Mairiaux, Philippe ULiege

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2003), 40(1), 5-17

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See detailTreatment failures and relapses in onychomycosis: a stubborn clinical problem.
Arrese Estrada, Jorge ULiege; Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 207(3), 255-60

The therapeutic outcome of onychomycoses is uncertain. Comparative short-term efficacy studies on antifungals abound and report contradictory findings. Few unbiased follow-up studies have scrutinized the ... [more ▼]

The therapeutic outcome of onychomycoses is uncertain. Comparative short-term efficacy studies on antifungals abound and report contradictory findings. Few unbiased follow-up studies have scrutinized the long-term outcome. Basically, none of the current antifungals can guarantee cure in all instances. In addition, relapses are not rare. The causes of therapeutic failure in onychomycoses are multiple. The most important are the lack of diagnostic accuracy, inadequate antifungal choice or delivery modality, and presence of dormant conidia, sequestrated mycelium pockets or resistant fungal species. The concept of fungicidal drug derived from selected in vitro studies appears irrelevant in clinical practice. [less ▲]

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See detailBisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells
Wins, Pierre; Margineanu, Ilca; Penelle, Jacques et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (2003), 367(3), 253-259

Several mono- and bisindole quaternary alkaloids isolated from the stem bark of Strychnos guianensis have recently been shown to be effective blockers of neuromuscular transmission in mice. In this study ... [more ▼]

Several mono- and bisindole quaternary alkaloids isolated from the stem bark of Strychnos guianensis have recently been shown to be effective blockers of neuromuscular transmission in mice. In this study, we used a human clonal cell line (TE671) expressing muscle-type nicotinic acetylcholine receptors. The agonist carbamylcholine activated a receptor-mediated Rb-86(+) efflux and this activation was antagonized by the indole alkaloids, the most active being bisindole bisquaternary compounds. The most effective antagonist, guiachrysine, had an IC50 around 0.43 muM in the presence of 0.5 mM carbamylcholine, compared to 0.16 muM for d-tubocurarine, the most potent curarizing alkaloid. Guiaflavine and 5',6'-dehydroguiaflavine were slightly less effective. Monoindole compounds were 10 to 100 times less potent than bisindole alkaloids. Kinetic analysis showed that the inhibition of the carbamylcholine-dependent Rb-86(+) efflux by guiaflavine was of mixed competitive and uncompetitive type. The competitive component (K-I = 0.21 muM) is presumably due to binding at the acetylcholine site, while the uncompetitive component (K'(I) = 0.92 muM) may be due to open channel block. [less ▲]

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See detailLes lymphomes
Jerusalem, Guy ULiege; Hustinx, Roland ULiege; Beguin, Yves ULiege et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2003), 27(8), 401-410

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique ... [more ▼]

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique concernant le diagnostic, la classification de la maladie et la détermination des facteurs pronostiques permet de choisir la thérapeutique la plus appropriée. Les auteurs passent en revue les examens à réaliser au diagnostic et discutent de la place de la tomographie à émission de positons (TEP) dans cette indication. Ils évoquent ensuite le problème des masses résiduelles. La TEP est maintenant l'examen de choix pour établir le bilan de fin de traitement. Les auteurs discutent également du rôle potentiel de la TEP pour l'évaluation thérapeutique précoce et le suivi régulier des patients après traitement pour lymphome. Enfin, l'aspect particulier des lymphomes de l'enfant est abordé. [less ▲]

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See detailAn X-ray Rietveld, infrared, and Mossbauer spectral study of the NaMn(Fe1-xInx)(2)(PO4)(3) alluaudite-type solid solution
Hatert, Frédéric ULiege; Hermann, Raphaël ULiege; Long, Gary J. et al

in American Mineralogist (2003), 88(1), 211-222

Several compounds of the NaMn(Fe1-xInx)(2)(PO4)(3) solid solution were synthesized by solid state reaction in air; pure alluaudite-like compounds were obtained for x = 0.00 to 1.00. X-ray Rietveld ... [more ▼]

Several compounds of the NaMn(Fe1-xInx)(2)(PO4)(3) solid solution were synthesized by solid state reaction in air; pure alluaudite-like compounds were obtained for x = 0.00 to 1.00. X-ray Rietveld refinements indicate the presence of Na+ at the A1 and A2' sites, Mn2+ at the M1 site, and Fe2+, Fe3+, and In3+ at the M2 site. The presence of small amounts of In3+ at the M I site, and Mn2+ at the M2 site, indicates a partially disordered distribution between these cations. A good correlation was also established between the M1-M2 bond distance and the beta angle of the alluaudite-like compounds. The disordered distribution of Fe2+, Fe3+, and In3+ at the M2 site is confirmed by the broadness of the infrared absorption bands. The Mossbauer spectra, measured between 90 and 295 K, were analyzed in terms of a model that takes into account the next-nearest neighbor interactions around the M2 crystallographic site. In all cases these spectra reveal the unexpected presence of small amounts of Fe2+ at the M2 site, an amount that decreases as the In3+ content increases. The Fe2+ and Fe3+ isomer shifts are typical of the alluaudite structure and vary with temperature, as expected from a second-order Doppler shift. The derived iron vibrating masses and Mossbauer lattice temperatures are within the expected range of values for iron cations in an octahedral environment. The Fe2+ and Fe3+ quadrupole splittings are also typical of the alluaudite structure and the temperature dependence of the Fe2+ quadrupole splitting was fit with the model of Ingalls (1964), which yielded a ground state orbital splitting of ca. 380 to 570 cm(-1) for the Fe2+ sites. [less ▲]

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See detailFrom skin microrelief to wrinkles. An area ripe for investigation.
Pierard, Gérald ULiege; Uhoda, Isabelle; Pierard, Claudine ULiege

in Journal of Cosmetic Dermatology (2003), 2(1), 21-8

Skin microrelief alters progressively with age. Wrinkles do not result from these changes but are superimposed upon them. Wrinkles result from structural changes in the epidermis, dermis and hypodermis ... [more ▼]

Skin microrelief alters progressively with age. Wrinkles do not result from these changes but are superimposed upon them. Wrinkles result from structural changes in the epidermis, dermis and hypodermis. Four types of wrinkles can be recognized. Type 1 wrinkles are atrophic. Type 2 wrinkles are elastotic. Type 3 wrinkles are expressional. Type 4 wrinkles are gravitational. Each type of wrinkle is characterized by distinct microanatomical changes and each type of wrinkle develops in specific skin regions. Each is likely to respond differently to treatment. Skin microrelief and skin folds can be identified on histological examination. By contrast, only minimal dermal changes are found beneath permanent or reducible wrinkles compared with immediately adjacent skin. A series of objective and non-invasive methods is available to quantify the severity of wrinkling. [less ▲]

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See detailLa responsabilité extra-contractuelle des dirigeants de sociétés
Caprasse, Olivier ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailBiodiversity, molecular phylogeny, and trophodynamics of amphipod crustaceans in the Antarctic deep-sea
De Broyer, Claude; Dauby, Patrick ULiege; Nyssen, Fabienne et al

in Berichte zur Polar- und Meeresforschung (2003), 470

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See detailResponsive corneosurfametry following in vivo skin preconditioning.
Uhoda, Emmanuelle ULiege; Goffin, Véronique ULiege; Pierard, Gérald ULiege

in Contact Dermatitis (2003), 49(6), 292-6

Skin is subjected to many environmental threats, some of which altering the structure and function of the stratum corneum. Among them, surfactants are recognized factors that may influence irritant ... [more ▼]

Skin is subjected to many environmental threats, some of which altering the structure and function of the stratum corneum. Among them, surfactants are recognized factors that may influence irritant contact dermatitis. The present study was conducted to compare the variations in skin capacitance and corneosurfametry (CSM) reactivity before and after skin exposure to repeated subclinical injuries by 2 hand dishwashing liquids. A forearm immersion test was performed on 30 healthy volunteers. 2 daily soak sessions were performed for 5 days. At inclusion and the day following the last soak session, skin capacitance was measured and cyanoacrylate skin-surface strippings were harvested. The latter specimens were used for the ex vivo microwave CSM. Both types of assessments clearly differentiated the 2 hand dishwashing liquids. The forearm immersion test allowed the discriminant sensitivity of CSM to increase. Intact skin capacitance did not predict CSM data. By contrast, a significant correlation was found between the post-test conductance and the corresponding CSM data. In conclusion, a forearm immersion test under realistic conditions can discriminate the irritation potential between surfactant-based products by measuring skin conductance and performing CSM. In vivo skin preconditioning by surfactants increases CSM sensitivity to the same surfactants. [less ▲]

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See detailAllons-nous mourir bronzés ou ostéomalaciques? Le dilemme de la protection solaire entre Charybde et Scylla
Uhoda, I.; Crestey, M.; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2003), 58(5), 307-9

Sun is at the origin of life. It can also be responsible for death. In the past decades cutaneous melanoma killed more and more young adults. Currently, the disease still progresses in the population, but ... [more ▼]

Sun is at the origin of life. It can also be responsible for death. In the past decades cutaneous melanoma killed more and more young adults. Currently, the disease still progresses in the population, but survival increases hopefully. Sun is pointed out as the main culprit. Hence, protection against harmful effects of ultraviolets is mandatory. However, preventive measures to be taken generate heated scientific argument. Sunlight exposure particularly in moderation is indeed necessary for health through vitamin D3 synthesis and psychological effects on wellbeing. Vitamin D3 provides numerous biological effects, particularly on bone calcification and also by inhibiting proliferation and migration of malignant cells including melanoma cells. Hence, we are facing the dilemma between too much and too little ultraviolet light exposure. Anyway, one cannot advocate that people lie in the sun until they burn or until they turn a rich brown complexion. [less ▲]

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See detailCTD measurements, with emphasis on Elephant Island surroundings
Dauby, Patrick ULiege

in Berichte zur Polar- und Meeresforschung (2003), 470

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See detailAnalysis Of Accessible Surface Of Residues In Proteins
Lins, Laurence ULiege; Thomas, Annick ULiege; Brasseur, Robert ULiege

in Protein Science : A Publication of the Protein Society (2003), 12(7),

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See detailModelling eutrophication in mesotidal and macrotidal estuaries. The role of intertidal seaweeds.
Alvera Azcarate, Aïda ULiege; Ferreira, Joao; Nunes, Joao

in Estuarine Coastal & Shelf Science (2003), 57

The role of intertidal seaweeds in the primary production of mesotidal and macrotidal estuaries has been examined by means of a model, applied to the Tagus Estuary (Portugal). Special attention was paid ... [more ▼]

The role of intertidal seaweeds in the primary production of mesotidal and macrotidal estuaries has been examined by means of a model, applied to the Tagus Estuary (Portugal). Special attention was paid to the description of the underwater light climate in intertidal areas, and to the importance of the formation of tidal pools. Two approaches were compared for the simulation of suspended particulate matter (SPM) in the pool areas, using three algal species. The use of an erosion–deposition approach to simulate the distribution of SPM in tidal pools gives an increase in net primary productivity per unit area of between 130 and 1300%, when compared to the more conventional approach where the suspended matter in the overlying water in intertidal areas is considered identical to that in the channels. The upscaled erosion–deposition model was applied to tidal pool areas and combined with the more conventional model for other intertidal areas. Results show that annual carbon fixation by intertidal seaweeds in the estuary exceeds 13,500 t C yr−1, and accounts for 21% of the total carbon fixed by all primary producers. The corresponding nitrogen removal by seaweeds corresponds to the annual nutrient loading of a population of 490,000 inhabitants. [less ▲]

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See detailAndropause and psychopathology: minor symptoms rather than pathological ones.
Delhez, Marie; Hansenne, Michel ULiege; Legros, Jean-Jacques ULiege

in Psychoneuroendocrinology (2003), 28(7), 863-74

This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects ... [more ▼]

This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects were 153 men, aged 50-70 years, who participated in a screening of andropause. Total testosterone, FSH, LH and SHBG levels were measured. Depressed mood was assessed with the Carroll Rating Scale, anxiety with the "anxiety-insomnia" dimension of the General Health Questionnaire, and quality of life with the World Health Organisation Quality of Life questionnaire. The results showed that levels of free T decreased with age, whereas FSH and LH increased. Carroll Rating Scale scores were higher among hypogonadal subjects, but the mean score was low and not pathological. A negative correlation was observed between severity of depression as assessed by the Carroll Rating Scale and free T levels. However, subjects with a significant score on this scale did not exhibit different free T levels compared to subjects with a non-significant depressive score. Anxiety and quality of life did not differ between hypogonadal and eugonadal subjects. The present study therefore suggests that andropause is not characterised by specific psychological symptoms, but may be associated with "depressive symptoms" that are not considered as pathological. [less ▲]

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See detailLe catastérisme chez Homère. Le cas d'Orion
Renaud, Jean-Michel ULiege

in Gaia. Revue interdisciplinaire sur la Grèce archaïque (2003), 7

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See detailCell Handling, Membrane-Binding Properties, And Membrane-Penetration Modeling Approaches Of Pivampicillin And Phthalimidomethylampicillin, Two Basic Esters Of Ampicillin, In Comparison With Chloroquine And Azithromycin
Chanteux, H.; Paternotte, I.; Mingeot-Leclercq, Mp. et al

in Pharmaceutical Research (2003), 20(4), 624-31

PURPOSE: The purpose of this work was to examine and understand the cellular pharmacokinetics of two basic esters of ampicillin, pivaloyloxymethyl (PIVA) and phthalimidomethyl (PIMA), in comparison with ... [more ▼]

PURPOSE: The purpose of this work was to examine and understand the cellular pharmacokinetics of two basic esters of ampicillin, pivaloyloxymethyl (PIVA) and phthalimidomethyl (PIMA), in comparison with lysosomotropic drugs (chloroquine, azithromycin). METHODS: Cell culture studies (J774 macrophages) were undertaken to study uptake and release kinetics and to assess the influence of concentration, pH, proton ionophore (monensin), and MRP and P-gp inhibitors (probenecid, gemfibrozil, cyclosporin A, GF 120918). Equilibrium dialysis with liposomes were performed to directly asses the extent of drug binding to bilayers. Conformational analysis modeling of the drug penetration in bilayers was conducted to rationalize the experimental observations. RESULTS: PIVA and PIMA showed properties in almost complete contrast with those of chloroquine and azithromycin, i.e., fast apparent accumulation and fast release at 4 degrees C as well as at 37 degrees C, saturation of uptake (apparent Kd 40 microM), no influence of monensin, MRP, or P-gp inhibitors; tight binding to liposomes (Kd approx. 40 microM); and sharp increase in calculated free energy when forced in the hydrophobic domain. CONCLUSIONS: Although they are weak organic bases, PIVA and PIMA show none of the properties of lysosomotropic agents. We hypothesize that they remain locked onto the pericellular membrane and may never penetrate cells as such in significant amounts. [less ▲]

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See detailCellular Uptake Of Antennapedia Penetratin Peptides Is A Two-Step Process In Which Phase Transfer Precedes A Tryptophan-Dependent Translocation
Dom, G.; Shaw-Jackson, C.; Matis, C. et al

in Nucleic Acids Research (2003), 31(2), 556-61

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third alpha ... [more ▼]

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third alpha-helix of the homeodomain, also known as Penetratin. Biophysical studies demonstrate that entry of Penetratin into cells requires its binding to surface lipids but that binding and translocation are differentially affected by modifications of some physico-chemical properties of the peptide, like helical amphipathicity or net charge. This suggests that the plasma membrane lipid composition affects the internalization of Penetratin and that internalization requires both lipid binding and other specific properties. Using a phase transfer assay, it is shown that negatively charged lipids promote the transfer of Penetratin from a hydrophilic into a hydrophobic environment, probably through charge neutralization. Accordingly, transfer into a hydrophobic milieu can also be obtained in the absence of negatively charged lipids, by the addition of DNA oligonucleotides. Strikingly, phase transfer by charge neutralization was also observed with a variant peptide of same charge and hydrophobicity in which the tryptophan at position 6 was replaced by a phenylalanine. However, Penetratin, but not its mutant version, is internalized by live cells. This underscores that charge neutralization and phase transfer represent only a first step in the internalization process and that further crossing of a biological membrane necessitates the critical tryptophan residue at position 6. [less ▲]

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See detailCombined enzymatic hydrolysis and HPAEC method for simultaneous analysis of galacturonic acid and neutral sugars of pectin.
Garna, H.; Mabon, N.; Wathelet, Bernard ULiege et al

in Communications in Agricultural and Applied Biological Sciences (2003), 68(2 Pt A), 297-300

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See detailDiurnal Centroid Of Ecosystem Energy And Carbon Fluxes At Fluxnet Sites
Wilson, Kb.; Baldocchi, D.; Falge, E. et al

in Journal of Geophysical Research. Atmospheres (2003), 108(D21),

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See detailIntercalative polymerization of cyclic esters in layered silicates : thermal vs. catalytic activation
Pantoustier, Nadège; Alexandre, Michaël ULiege; Degée, Philippe et al

in Composite Interfaces (2003), 10(4-5), 423-433

Poly(ε-caprolactone) layered silicate nanocomposites were synthesized by in situ inter-calative ring-opening polymerization (ROP) of ε-caprolactone. The polymerization was promoted by thermal or catalytic ... [more ▼]

Poly(ε-caprolactone) layered silicate nanocomposites were synthesized by in situ inter-calative ring-opening polymerization (ROP) of ε-caprolactone. The polymerization was promoted by thermal or catalytic initiation starting from either non-modified natural sodium-montmorillonite (MMT-Na) or montmorillonite modified by different ammonium cations bearing either non-functional alkyl chains or chains terminated by carboxylic acid or hydroxyl functions. The resulting compositions were analyzed by small-angle X-ray diffraction and transmission electron microscopy. The clay dispersion depended on the structure of the alkyl ammonium. Exfoliated nanocomposites were formed when hydroxyl-containing alkyl-ammonium was used; otherwise, partially intercalated/partially exfoliated structures were observed. Moreover, caving to the inherent catalytic properties of the montmo-rillomte surface, it was also possible to prepare intercalated nanocomposites by in situ polymerization of ε-caprolactone in presence of non-modified montmorillonite-Na (MMT-Na) without any added catalyst. [less ▲]

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See detailMilitantisme pas mort ?
Biquet, Véronique ULiege; Jacquemain, Marc ULiege; Stangherlin, Gregor

in Politique : Revue de Débats (2003), (29), 12-15

L'article reprend les thèses classiques sur la transformation du militantisme vers un engagement distancié (Ion) en montrant comment ces thèses peuvent s'appuyer sur les théories du postmatérialisme ... [more ▼]

L'article reprend les thèses classiques sur la transformation du militantisme vers un engagement distancié (Ion) en montrant comment ces thèses peuvent s'appuyer sur les théories du postmatérialisme (Inglehart). Il s'interroge aussi sur la capacité de l'altermondialisme, dans ce contexte, à constituer à terme une alternative au militantisme classique. [less ▲]

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See detailEnfin "Tubambe" devoile son identite! Hadraphe ethiopica (Bethune-Baker) (Limacodidae), une chenille comestible des forets claires zambeziennes.
Malaisse, François ULiege; Demesmaecker, Anne; Matera, Joseph et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(2), 67-77

La consommation humaine de chenilles de Limacodidae avait été signalée en Afrique centro-australe. L’une de ces espèces, Hadraphe ethiopica, a été déterminée. Des données relatives à sa biologie ont été ... [more ▼]

La consommation humaine de chenilles de Limacodidae avait été signalée en Afrique centro-australe. L’une de ces espèces, Hadraphe ethiopica, a été déterminée. Des données relatives à sa biologie ont été rassemblées. Des analyses d’échantillons séchés ont permis de préciser leur composition chimique et leur valeur nutritionnelle, notamment sur le plan des acides aminés et des acides gras. [less ▲]

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See detailDust-acoustic modes in plasmas with dust distributions and charge fluctuations
Verheest, F.; Jacobs, G.; Cattaert, Tom ULiege

in New Journal of Physics (2003), 5

Charge fluctuations in dusty plasmas are discussed starting from charge, mass, momentum and current equations for the combined dusty plasma. This allows a generic description of low-frequency waves in ... [more ▼]

Charge fluctuations in dusty plasmas are discussed starting from charge, mass, momentum and current equations for the combined dusty plasma. This allows a generic description of low-frequency waves in plasmas with dust distributions, and leads to the damping and other modifications of the dust-acoustic and related modes, like generalized dust-Coulomb modes. [less ▲]

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See detailA retrospective study of non-specific rhinitis in 22 cats and the value of nasal cytology and histopathology
Michiels, L.; Day, M. J.; Snaps, Frédéric ULiege et al

in Journal of Feline Medicine and Surgery (2003), 5(5), 279-285

Case records from 40 cats subjected to rhinoscopic examination for investigation of chronic nasal disease were reviewed. Cases in which no specific underlying cause (eg neoplasia) was detected were ... [more ▼]

Case records from 40 cats subjected to rhinoscopic examination for investigation of chronic nasal disease were reviewed. Cases in which no specific underlying cause (eg neoplasia) was detected were further selected for detailed retrospective study. In these 22 cats (55% of the initial population), a final diagnosis of non-specific chronic nasal disease was made. The radiographic, rhinoscopic, cytological and histopathological findings were reviewed. Mucosal biopsy specimens were obtained in 20 cases. Despite clinical signs of more than 4 weeks duration, histopathology indicated acute inflammation in four cases. Two cases had chronic lymphoplasmacytic inflammation and 14 had mixed (lymphoplasmacytic and neutrophilic) inflammation. Specimens for cytology were obtained from 17 cases by brush sampling. Three of these samples were not diagnostic due to the poor quality of the slides; one showed normal cytology. Acute inflammation was diagnosed by cytology (n = 11) more commonly than chronic (n = 1) or mixed inflammation (n = 1). Concurrent samples, of quality suitable for both histopathological and cytological interpretation, were collected from 12 cases only. Cytological results were in agreement with the histological results in 25%, of these cases, the main discrepancy being the nature of the dominant inflammatory cell type. Therefore cytology does not appear to be a reliable means for detection of chronic inflammation. Further studies are needed in order to investigate the correlation between the nature of mucosal inflammation as defined by both histological and cytological evaluation, and the relationship of these test results to prognosis and therapy. (C) 2003 Published by Elsevier Ltd on behalf of ESFM and AAFP. [less ▲]

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See detailCreolization in Robert Antoni's Blessed Is the Fruit: A Linguistic Analysis
Ledent, Bénédicte ULiege

in Matatu : Journal for African Culture and Society (2003), 27-28

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See detailHigh-Performance Liquid Chromatography Analyses Of Pyoverdin Siderophores Differentiate Among Phytopathogenic Fluorescent Pseudomonas Species
Bultreys, Alain; Gheysen, Isabelle; Wathelet, Bernard ULiege et al

in Applied and Environmental Microbiology (2003), 69(2),

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See detailFronts and mesoscale variability in the southern Indian Ocean as inferred from the TOPEX/POSEIDON and ERS-2 altimetry data
Kostianoy, Andrey G.; Ginzburg, Anna I.; Lebedev, Sergey Anatolievich et al

in Oceanology (2003), 43(5, SEP-OCT), 632-642

Charts of sea level anomalies (SLA) based on the combined altimetry data from the TOPEX/POSEIDON and ERS-2 satellites, as well as the corresponding charts of the sea surface dynamic heights (constructed ... [more ▼]

Charts of sea level anomalies (SLA) based on the combined altimetry data from the TOPEX/POSEIDON and ERS-2 satellites, as well as the corresponding charts of the sea surface dynamic heights (constructed by the superposition of SLA distributions over the climatic dynamic topography) and the temperature gradients at the ocean surface on the basis of the satellite Multi-Channel Sea Surface Temperature (MCSST) data, were used to study the mesoscale variability related to the fronts in the Southern Indian Ocean (30degrees-60degrees S, 20degrees-150degrees E). An analysis of these three types of satellite information for the central weeks of each month during the period from 1997 to 1999 allowed us to distinguish zones of enhanced meandering (eddy formation) within the basin under study, as well as the contributions of individual fronts and their interaction to the regional mesoscale variability. The problems of the correlation between the intensity of mesoscale variability and peculiarities of the local bottom topography and seasonal/interannual variability of mesoscale dynamics are addressed. [less ▲]

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See detailResolution of chylothorax after resection of rib chondroma in a dog
Watine, Séverin; Hamaide, Annick ULiege; Peeters, Dominique ULiege et al

in Journal of Small Animal Practice (2003), 44(12), 546-549

A six-year-old, male dobermann was presented with a history of dyspnoea and bouts of coughing. Radiography and computed tomography of the thorax showed pleural effusion and a well-circumscribed, calcified ... [more ▼]

A six-year-old, male dobermann was presented with a history of dyspnoea and bouts of coughing. Radiography and computed tomography of the thorax showed pleural effusion and a well-circumscribed, calcified mass of 10 cm in diameter, appearing to originate from the left first rib. Thoracocentesis revealed that the pleural fluid was chylous in nature. An inclsional biopsy was performed, which gave a histological diagnosis of chondroma. Resolution of the chylothorax after en-bloc surgical removal of the tumour suggested that the rib tumour was the initiating cause of the chylothorax. Seventeen months later, rib neoplasia recurred without pleural effusion, and was removed successfully. To the authors' knowledge, rib chondroma, which is an unusual tumour in dogs, has not been previously documented as a cause of chylothorax. [less ▲]

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See detailReich-Ranicki und die ‚Erotik'. In: Das Internet-Portal Marcel Reich-Ranicki
Pontzen, Alexandra ULiege

in Literaturkritik.de (2003)

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See detailEmile Adan en de introductie van reisinstructies voor de Belgische wetenschappelijke exploratie in Midden-Afrika.
Vandersmissen, Jan ULiege

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in Belgie (2003), 74(1-4), 205-217

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See detailPatterns Of Bryophyte Diversity And Rarity At A Regional Scale
Vanderpoorten, Alain ULiege; Engels, Patrick ULiege

in Biodiversity & Conservation (2003), 12(3),

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See detailThe emotional content of material and reality monitoring function in subjects predisposed towards hallucinations
Laroi, Frank ULiege; Marczewski, P.; Van der Linden, Martial ULiege et al

in Brain and Cognition (2003), 51

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See detailThe family systems approach to treating families of persons with brain injury: a potential collaboration between family therapist and brain injury professional
Laroi, Frank ULiege

in Brain Injury (2003), 17

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a ... [more ▼]

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a family education and support perspective and not from a family therapy perspective. The aim of the following paper is to illustrate the important role that a family systems approach can play in treating families of individuals with brain injury. In particular, clinical examples taken from the literature will be presented that illustrate how family roles can be modified as a consequence of a brain injury, and the importance of re-establishing or re-distributing these roles. It will be argued that an intimate collaboration between family therapist and brain injury professional is essential, and that the ideal professional make-up of clinicians working with families of persons with brain injury are those well-versed in both brain injury rehabilitation and family therapy. [less ▲]

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See detailL'image du mois. Myiase furonculoide americaine.
Leonard, Philippe ULiege; Martalo, O.; Pierard, Gérald ULiege

in Revue Médicale de Liège (2003), 58(12), 721-2

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See detailILLUSTRATION OF MODERN BENTHIC FORAMINIFERA FROMBERMUDA AND REMARKS ON DISTRIBUTION IN OTHER SUBTROPICAL/TROPICAL AREAS
Javaux, Emmanuelle ULiege; Scott, David

in Palaeontologia Electronica (2003), 6(4), 1-29

A scanning light microscope (SLM) is used to illustrate recent benthic foraminiferal species from surface sediment samples collected in Bermuda subtropical environments. Species illustrated here are the ... [more ▼]

A scanning light microscope (SLM) is used to illustrate recent benthic foraminiferal species from surface sediment samples collected in Bermuda subtropical environments. Species illustrated here are the main foraminiferal species found in Bermuda lagoons, reefs, caves, mangroves, and ponds, but also occur in most subtropical and tropical areas. The SLM permits photography of specimens without coating and gives pictures most similar to specimens that micropaleontologists see under a dissecting reflected light microscope in a petri dish with water, in contrast to images made with scanning electron microscopes. These pictures are the first SLM illustrations of subtropical/tropical species of benthic foraminifera and will be very useful for their identification. Bermuda recent sediment hosts a benthic foraminifera fauna as diverse as in other subtropical and tropical areas, and the general trends of foraminiferal distribution and morphology are similar. Remarks on foraminiferal distribution in Bermuda and other subtropical/tropical areas are also presented. [less ▲]

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See detailLe vers contemporain : recherches et innovations en France dans les années 80 et 90
Purnelle, Gérald ULiege

in Formes poétiques contemporaines (2003), 1

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See detailCloches et plaies des pieds.
Crosset, A.; Uhoda, Emmanuelle ULiege; Pierard, Gérald ULiege

in Pharma-Sphère (2003), 78

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See detailAtypical recurrent varicella in 4 patients with hemopathies.
Nikkels, Arjen ULiege; Simonart, Thierry; Kentos, Alain et al

in Journal of the American Academy of Dermatology (2003), 48(3), 442-7

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with ... [more ▼]

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with malignant hemopathies who had an unusual form of recurrent varicella develop. Conventional microscopy, immunohistochemistry, and in situ hybridization were applied to smears and skin biopsy specimens. The patients presented a few dozen, scattered, large, papulovesicular lesions with central crusting. No zoster-associated pain or dermatomal distribution of the lesions was noted. Conventional microscopy revealed vascular changes and epidermal alterations typical for alpha-herpes virus infection. The varicella zoster virus major viral envelope glycoproteins gE and gB, and the immediate-early varicella zoster virus IE63 protein and the corresponding genome sequence for gE were detected on Tzanck smears; they were localized in endothelial cells and keratinocytes on skin biopsy specimens. The varicella zoster virus infection in endothelial cells, the vascular involvement, and the widespread distribution of the lesions suggest that the reported eruptions are vascular rather than neural in origin. These findings invalidate the diagnosis of herpes zoster but strongly support the diagnosis of recurrent varicella in an indolent and yet unreported presentation. Furthermore, these eruptions differ from relapsing varicella in children and young adults by the age of the patients, the paucity of clinical lesions, the larger diameter of the lesions and their peculiar clinical aspect, the significantly longer time interval between primary varicella and the recurrence, the prolonged healing time of the lesions, their mild disease course, and the fact that all the lesions are in the same stage of development. [less ▲]

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See detailAlcoolisme ou aldehydisme : Role de l'acetaldehyde dans les effets psychotropes de l'alcool
Quertemont, Etienne ULiege

in Alcoologie et Addictologie (2003), 25(1), 33-39

De récentes études ont suggéré que l’acétaldéhyde, premier produit du métabolisme de l’éthanol, participe aux effets psychotropes résultant de la consommation d’alcool. L’acétaldéhyde semble ... [more ▼]

De récentes études ont suggéré que l’acétaldéhyde, premier produit du métabolisme de l’éthanol, participe aux effets psychotropes résultant de la consommation d’alcool. L’acétaldéhyde semble particulièrement impliqué dans les effets renforçants de l’éthanol, ce qui suggère un rôle important pour ce métabolite dans l’abus d’alcool et l’alcoolisme. Cette mise au point passe en revue les preuves expérimentales qui tendent à démontrer le rôle de l’acétaldéhyde dans les effets psychotropes de l’alcool. Les études animales et humaines indiquent que l’acétaldéhyde exerce une action renforçante plus puissante que l’éthanol dans le cerveau. Au contraire, il semble que l’accumulation d’acétaldéhyde dans le sang périphérique provoque des effets désagréables et une aversion pour l’alcool. Les effets hédoniques de l’acétaldéhyde seraient donc déterminés par le lieu, central ou périphérique, de son accumulation principale. Toutefois, l’acétaldéhyde ne doit pas être considéré comme le seul principe actif responsable de tous les effets psychotropes de l’éthanol. Plusieurs études ont par exemple démontré que l’acétaldéhyde ne participe pas significativement aux effets subjectifs de l’éthanol. Si l’acétaldéhyde exerce effectivement un rôle dans les effets renforçants de l’éthanol, il ne doit donc pas être tenu pour responsable de tous les effets pharmacologiques de la consommation d’alcool. [less ▲]

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See detailElectromagnetic modes in dusty plasmas with charge and mass distributions
Verheest, F.; Cattaert, Tom ULiege

in Physics of Plasmas (2003), 10(4), 956-962

Electromagnetic modes in dusty plasmas are studied for polydisperse dust grains with a distribution in charge and mass. Owing to the different charge and mass weightings of the velocities, there occurs an ... [more ▼]

Electromagnetic modes in dusty plasmas are studied for polydisperse dust grains with a distribution in charge and mass. Owing to the different charge and mass weightings of the velocities, there occurs an infinite chain of equations of motion, coupled through the magnetic part of the Lorentz force. Depending on the frequency and associated convergence regimes, one has to close the chain in ascending or in descending order. Both series together lead to the polydisperse dispersion law that is a generalization of monodisperse or size distributed dust. Power-law distributions typical for heliospheric plasmas are discussed as an application. (C) 2003 American Institute of Physics. [less ▲]

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See detailSkin-lightening products revisited.
Petit, Ludivine; Pierard, Gérald ULiege

in International Journal of Cosmetic Science (2003), 25(4), 169-81

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and ... [more ▼]

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and phaeomelanins are of utmost importance. These biomolecules result from the multi-step enzymatic and non-enzymatic conversion of tyrosine into melanins. Pigmentation disorders are multiple and depend on alterations in the density in active melanocytes, and on specific abnormalities of any of the complex melanogenesis mechanisms. This review presents some of the main skin-lightening agents with respect to their mechanisms of action and side-effects. Some of the novel compounds may lead to new perspectives in the fields of dermatology and cosmetology. The methods commonly used to assess efficacy of skin-lightening products rely on in vitro models including cell-free enzymatic assays, melanocyte cultures and reconstructed epidermis bioassays. Animal models have little relevance. By contrast, human testing with the support of instrumental evaluations is the most informative. [less ▲]

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See detailMycotoxins in stored Barley (Hordeum vulgare) in Tibet Autonomous Region (People’s Republic of China.
Haubruge, Eric ULiege; Chasseur, Camille

in Mountain Research & Development (2003), 23

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See detailLombalgies et remise au travail : Quel modèle d'intervention privilégier ?
Mairiaux, Philippe ULiege

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2003), XL(4), 185-188

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See detailTrou Al'Wesse : Rapport préliminaire des fouilles 2003
Miller, Rebecca ULiege; Otte, Marcel ULiege

in Notae Praehistoricae (2003), 23

This article presents a summary of the first field season of the second phase of excavations at the site of Trou Al'Wesse as well as proposing a series of hypotheses concerning possible contacts between ... [more ▼]

This article presents a summary of the first field season of the second phase of excavations at the site of Trou Al'Wesse as well as proposing a series of hypotheses concerning possible contacts between Mesolithic and Neolithics populations. [less ▲]

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See detailAmphiphilic copolymers of epsilon-caprolactone and gamma-substituted epsilon-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles
Gautier, Sandrine; D'Aloia, Violetta; Halleux, Olivier et al

in Journal of Biomaterials Science. Polymer Edition (2003), 14(1), 63-85

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were ... [more ▼]

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were synthesized by controlled copolymerization of epsilon-caprolactone and epsilon-caprolactone substituted in the gamma-position by a hydrophilic X group, where X is either a cationic pyridinium (gamma-Py-CL) or a non-ionic hydroxyl (gamma-OH-CL). Nanoparticles were prepared by co-precipitation of PLA with the P(CL-co-gamma-XCL) copolyester from a DMSO solution. Small amounts of cationic P(CL-co-gamma-Py-CL) copolymers are needed to quantitatively form stable nanoparticles (ca. 10 mg/100 mg PLA), although larger amounts of non-ionic P(CL-co-gamma-OH-CL) copolymers are needed (ges12.5 mg/100 mg PLA). Copolymers with a low degree of polymerization (ca. 40) are more efficient stabilizers, probably because of faster migration towards the nanoparticle-water interface. The nanoparticle diameter decreases with the polymer concentration in DMSO, e.g. from ca. 160 nm (16 mg/ml) to ca. 100 nm (2 mg/ml) for PLA/P(CL-co-gamma-Py-CL) nanoparticles. Migration of the P(CL-co-gamma-XCL) copolyesters to the nanoparticle surface was confirmed by measurement of the zeta potential, i.e. ca. +65 mV for P(CL-co-gamma-Py-CL) and -7 mV for P(CL-co-gamma-OH-CL). The polyamphiphilic copolyesters stabilize PLA nanoparticles by electrostatic or steric repulsions, depending on whether they are charged or not. They also impart functionality and reactivity to the surface, which opens up new opportunities for labelling and targeting purposes. [less ▲]

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See detailRhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.
Clercx, Cécile ULiege; Reichler, I.; Peeters, Dominique ULiege et al

in Journal of Veterinary Internal Medicine (2003), 17(6), 843-9

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK ... [more ▼]

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent rhinorrhea, cough, and respiratory dyspnea. Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected dogs, but no characteristic primary ciliary defects (primary ciliary dyskinesia) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected dogs and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected dogs tested, whereas BALF IgA concentration was above the normal range in 2 affected adult dogs. The CD4 to CD8 lymphocyte subset ratio (CD4:CD8) in peripheral blood was tested in 3 affected dogs and was within the normal range. BALF CD4:CD8 was tested in 1 affected dog and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 dogs tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss dogs revealed common ancestry, suggesting a heritable syndrome. [less ▲]

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See detailLe cancer medullaire de la thyroide ou, comment des marqueurs tumoraux et les outils de la genetique autorisent le deploiement de mesures preventives.
Meurisse, Nicolas ULiege; Defechereux, Thierry ULiege; Hamoir, Etienne ULiege et al

in Revue Médicale de Liège (2003), 58(5), 346-350

Medullary thyroid cancer (MTC) arises from parafollicular C cells secreting calcitonin. MTC occurs both as sporadic tumors and as part of specific inherited autosomal dominant syndromes in which point ... [more ▼]

Medullary thyroid cancer (MTC) arises from parafollicular C cells secreting calcitonin. MTC occurs both as sporadic tumors and as part of specific inherited autosomal dominant syndromes in which point mutations within a discrete set of RET codons were described. Total thyroidectomy and aggressive neck dissection represents the only chance for cure in the affected patients. Therefore, all patients with thyroid nodular disease should undergo measurement of calcitonin plasma levels to allow preclinical diagnosis of the disease and early appropriate surgery ("secondary prevention"). In case of proband patient for inherited disease, all the family members should be genetically screened to detect the disease gene carriers. Patients with germline mutation would benefit either from earlier surgery at the stage of C-cell hyperplasia or microcarcinoma or prophylactic surgery (total thyroidectomy without neck dissection) (primary prevention) before the onset of any C-cells pathology. The ideal age for performance of such prophylactic surgery is determined by the genotypic features of the disease. [less ▲]

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See detailPhylogeny
Baudoin, Jean-Pierre ULiege; Maquet, A.

in Plant and Soil (2003), 252(1), 55-128

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See detailSapling diversity in canopy gaps in an Ecuadorian rain forest.
Salvador-Van Eysenrode, D; Bogaert, Jan ULiege; Zak-Mnacek, V et al

in Forest Science (2003), 49(6), 909-917

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See detailLe Gigantisme : Un mystère élucidé
Beckers, Albert ULiege

in Revue Roumaine d'Endocrinologie (2003), 2(4), 88-9394-97

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See detailZur diatopischen Gliederung des alltagssprachlichen Wortgebrauchs
Möller, Robert ULiege

in Zeitschrift für Dialektologie und Linguistik (2003), 70

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See detailNudging epidermal field cancerogenesis by imiquimod.
Uhoda, Isabelle; Quatresooz, Pascale ULiege; Pierard, Claudine ULiege et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 357-60

BACKGROUND: The coexistence of malignancies close to each other on the skin has been occasionally reported. The concept of field cancerogenesis applies to such cases. Given the purported mechanism of ... [more ▼]

BACKGROUND: The coexistence of malignancies close to each other on the skin has been occasionally reported. The concept of field cancerogenesis applies to such cases. Given the purported mechanism of action of imiquimod, it should not be surprising that this treatment could inhibit epidermal field cancerogenesis. AIM: To assess the effect of imiquimod applied twice weekly on incipient bowenoid changes disclosed in the vicinity of basal cell carcinomas. MATERIALS AND METHOD: Biopsies were taken before treatment and after 4-6 weeks and 12 weeks of imiquimod treatment. RESULTS: Large atypical bowenoid keratinocytes and dyskeratotic cells were cleared in time while factor-XIIIa-positive dermal dendrocytes appeared boosted and admixed with a brisk lymphocytic infiltration. CONCLUSION: Epidermal field cancerogenesis appears to be controlled by imiquimod. Dermal dendrocytes might play a pivotal role in this regression phenomenon. [less ▲]

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See detailAnalyses technologiques d'un atelier de taille aurignacien à Maisières - Canal (Province du Hainaut, Belgique)
Miller, Rebecca ULiege; Flas, Damien; Guillaume, Alain et al

in Notae Praehistoricae (2003), 23

This articles presents the results of the spatial distribution of lithic refits and a dynamic technological analysis of the Aurignacian assemblage from the site of Maisières-Canal.

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See detailLe délai de prescription de l'action civile résultant d'une infraction : fin d'une controverse
Monville, Pierre ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailThe cutting edge of superabrasives quality control
Pirard, Eric ULiege

in Industrial Diamond Review (2003), 03(3), 49-50

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See detailGuidelines for the use of epoetin: have quality-of-life benefits been proven?
Bottomley, Andrew; Thomas, Ronald; Van Steen, Kristel ULiege et al

in Journal of Clinical Oncology (2003), 21(11), 22232224-5

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See detailPerfluorocarbons and Haemoglobin Solutions: Will They Ever Reach Clinical Practice?
Lamy, Maurice ULiege; Deby-Dupont, G.

in Acta Anaesthesiologica Belgica (2003), 54(4), 299-300

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See detailA local influence approach applied to binary data from a psychiatric study.
Jansen, Ivy; Molenberghs, Geert; Aerts, Marc et al

in Biometrics (2003), 59(2), 410-9

Recently, a lot of concern has been raised about assumptions needed in order to fit statistical models to incomplete multivariate and longitudinal data. In response, research efforts are being devoted to ... [more ▼]

Recently, a lot of concern has been raised about assumptions needed in order to fit statistical models to incomplete multivariate and longitudinal data. In response, research efforts are being devoted to the development of tools that assess the sensitivity of such models to often strong but always, at least in part, unverifiable assumptions. Many efforts have been devoted to longitudinal data, primarily in the selection model context, although some researchers have expressed interest in the pattern-mixture setting as well. A promising tool, proposed by Verbeke et al. (2001, Biometrics 57, 43-50), is based on local influence (Cook, 1986, Journal of the Royal Statistical Society, Series B 48, 133-169). These authors considered the Diggle and Kenward (1994, Applied Statistics 43, 49-93) model, which is based on a selection model, integrating a linear mixed model for continuous outcomes with logistic regression for dropout. In this article, we show that a similar idea can be developed for multivariate and longitudinal binary data, subject to nonmonotone missingness. We focus on the model proposed by Baker, Rosenberger, and DerSimonian (1992, Statistics in Medicine 11, 643-657). The original model is first extended to allow for (possibly continuous) covariates, whereafter a local influence strategy is developed to support the model-building process. The model is able to deal with nonmonotone missingness but has some limitations as well, stemming from the conditional nature of the model parameters. Some analytical insight is provided into the behavior of the local influence graphs. [less ▲]

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See detailL'image du mois. Hématome hépatique après une réanimation cardio-pulmonaire
Delanaye, Pierre ULiege; De Fooz, Geoffroy; NCHIMI LONGANG, Alain ULiege et al

in Revue Médicale de Liège (2003), 58(7-8, Jul-Aug), 463-464

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See detailThe Zápara Indians : the Consecration of an Endangered People
Bilhaut, Anne-Gaël ULiege

in Museum International (2003), 55(2), 25-30

Focuses on the United Nations Educational, Scientific and Cultural Organization's (UNESCO) declaration of the oral heritage and cultural manifestations of the Zápara people of Amazonia as a 'Masterpiece ... [more ▼]

Focuses on the United Nations Educational, Scientific and Cultural Organization's (UNESCO) declaration of the oral heritage and cultural manifestations of the Zápara people of Amazonia as a 'Masterpiece of the Oral and Intangible Heritage of Humanity.' Impact that the UNESCO recognition has had on the Zápara; Details of how the Zápara were able to secure sacred status from the UNESCO. [less ▲]

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See detailThe use of data assimilation in coupled hydrodynamic, ecological and biogeochemical models of the ocean
Grégoire, Marilaure ULiege; Brasseur, Pierre; Lermusiaux, Pierre

in Journal of Marine Systems (2003), 40-41(1-3), 405

The International Lie`ge Colloquium on Ocean Dynamics is organized annually. The topic differs from year to year in an attempt to address, as much as possible, recent problems and incentive new subjects ... [more ▼]

The International Lie`ge Colloquium on Ocean Dynamics is organized annually. The topic differs from year to year in an attempt to address, as much as possible, recent problems and incentive new subjects in oceanography. Assembling a group of active and eminent scientists from various countries and often different disciplines, the Colloquia provide a forum for discussion and foster a mutually beneficial exchange of information opening on to a survey of recent discoveries, essential mechanisms, impelling question marks and valuable recommendations for future research. The objective of the 2001 Colloquium was to evaluate the progress of data assimilation methods in marine science and, in particular, in coupled hydrodynamic, ecological and bio-geo-chemical models of the ocean. [less ▲]

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See detailEffect of different doses of prostaglandin on the area of corpus luteum, the largest follicle and progesterone concentration in the dairy cow
Repasi, A.; Beckers, Jean-François ULiege; Sulon, Joseph ULiege et al

in Reproduction in Domestic Animals (2003), 38(6), 423-428

Lactating dairy cows with a mature corpus luteum (CL) (diameter of greater than or equal to17 mm determined by ultrasonography) and having a follicle with a diameter of 10 mm (n = 49) were randomly ... [more ▼]

Lactating dairy cows with a mature corpus luteum (CL) (diameter of greater than or equal to17 mm determined by ultrasonography) and having a follicle with a diameter of 10 mm (n = 49) were randomly assigned to three groups. The first group was treated with a single dose of exogenous prostaglandin (25 mg), while the second group was treated with 35 mg on day 0, and the third group served as control in order to evaluate the effect of rectal manipulation on the CL during ultrasonographic examination. Blood samples were collected daily for analysing progesterone (P4) concentrations. In group 1 the incidence of oestrus and artificial insemination (AI) in 10 days after treatment was 95% (19 of 20). The conception rate was 31.6%, and the average time to oestrus after treatment was 3.7 day. In group 2 the incidence of oestrus and A.I. was 84.2% (16/19). The conception rate was 31.2%, and the average time to oestrus after treatment was 2.8 day. In the untreated group only two cows (2/10) exhibited oestrus during the examined period and none of them became pregnant. There were no significant differences between the two treated groups in terms of reduction in the area of CL and P4 concentrations and of an increase in the area of the dominant follicles. At the same time, the decrease in the percentage changes relative to the area of CL and to the concentrations of P4 were statistically significant in both treated groups. [less ▲]

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See detailModulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene.
Grobet, Luc ULiege; Pirottin, Dimitri ULiege; Farnir, Frédéric ULiege et al

in Genesis (2003), 35(4), 227-38

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular ... [more ▼]

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. [less ▲]

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See detailInorganic and organic carbon biogeochemistry in the Gautami Godavari estuary (Andhra Pradesh, India) during pre-monsoon : the local impact of extensive mangrove forests
Bouillon, Steven; Frankignoulle, Michel; Dehairs, Frank et al

in Global Biogeochemical Cycles (2003), 17(4),

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the ... [more ▼]

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the oligohaline and mesohaline section (salinity 0–15) of the estuary, internal production of total alkalinity (TAlk) and dissolved inorganic carbon (DIC) was recorded, and the d13CDIC profile suggests that carbonate dissolution may be an important process determining the DIC dynamics in this section of the Godavari. The partial pressure of CO2 (pCO2) was fairly low along the entire salinity gradient, (293–500 ppm), but much higher and more variable (1375–6437 ppm) in the network of tidal mangrove creeks in the delta. Here, variations in the concentration and d13C of the DIC pool were shown to result largely from the mineralization of organic matter. The present study clearly identifies the mangrove creeks as an active site of mineralization and CO2 efflux to the atmosphere, but shows that these changes in the aquatic biogeochemistry are a localized feature, rapidly fading in the adjacent Kakinada Bay. Our data indicate that mineralization of dissolved organic carbon (DOC) of mangrove origin, and its subsequent efflux as CO2 to the atmosphere may represent an important fate for mangrove carbon. Although further quantification of this process in a variety of systems is required, we suggest that some of the current ideas on the role of mangroves in the carbon budget of the coastal zone may need to be reconsidered. [less ▲]

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See detailThe course of some bone remodelling plasma metabolites in healthy horses and in horses offered a calcium-deficient diet.
de Behr, V.; Daron, D.; Gabriel, Annick ULiege et al

in Journal of Animal Physiology & Animal Nutrition (2003), 87(3-4), 149-59

An inquiry was carried out to assess the concentrations of plasma metabolites related to bone remodelling in 21 saddle horses of Warmblood breed aged 4-26 years, five draught horses of Ardennes breed aged ... [more ▼]

An inquiry was carried out to assess the concentrations of plasma metabolites related to bone remodelling in 21 saddle horses of Warmblood breed aged 4-26 years, five draught horses of Ardennes breed aged 4-10 years, and 10 Ardennes foals aged 9-11 months. They were fed according to normal feeding practice in Belgium. The changes in some bone remodelling plasma metabolite concentrations were studied when an unbalanced diet was offered and later corrected for four Warmblood horses. Bone formation was evaluated by bone alkaline phosphatase (BALP), total alkaline phosphatase (TALP) and osteocalcin (bone gla-protein, OC). Bone resorption was assessed by hydroxyproline (HYP). Total calcium, ionized calcium, phosphorus (P) and 25-hydroxyvitamin D3 [25-(OH)D] concentrations were more or less constant. The comparison of four bone remodelling factors between the Ardennes and Warmblood horses showed higher concentrations in the Ardennes breed. Bone marker concentrations decreased according to age. The correction of the unbalanced Ca : P diet induced inconsistent effects at plasma level. The interpretation of the different bone parameters appeared to be difficult if not associated with other parameters such as a complete anamnesis and clinical examination of the animal in addition to dietary evaluation. [less ▲]

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See detailDistribution of surface carbon dioxide and air-sea exchange in the English Channel and adjacent areas
Borges, Alberto ULiege; Frankignoulle, Michel

in Journal of Geophysical Research (2003), 108(C5),

In the present paper we report the distribution of the partial pressure of CO2 (pCO2) in surface waters along 13 transects in the English Channel, covering the four seasons. The spatial and temporal ... [more ▼]

In the present paper we report the distribution of the partial pressure of CO2 (pCO2) in surface waters along 13 transects in the English Channel, covering the four seasons. The spatial and temporal variability of pCO2 is controlled by a complex combination of primary production (from May to June), degradation of organic matter, temperature change, and freshwater inputs. Preliminary air-sea CO2 exchange computations suggest that the Channel is not a major sink of atmospheric CO2 and is probably neutral from the point of view of atmospheric coupling. This is mainly related to a relatively low export and/or burial of organic carbon and intense benthic calcification. [less ▲]

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See detailCarbon dioxide daily variations and atmospheric fluxes over the Great Bahama Bank using a novel autonomous measuring system
Frankignoulle, Michel; Biondo, Renzo ULiege; Théate, Jean-Marie et al

in Caribbean Journal of Sience (2003), 39(3), 257-264

A novel autonomous measuring device that acquires the partial pressure of CO2 (pCO2) by equilibration and several other parameters is described. This device, the Floating Equilibrator System (FES) was ... [more ▼]

A novel autonomous measuring device that acquires the partial pressure of CO2 (pCO2) by equilibration and several other parameters is described. This device, the Floating Equilibrator System (FES) was tested in field conditions for the first time in the Great Bahama Bank, in December 2000. We successfully carried out two 24 h cycles in Norman’s Pond, one in front of the Caribbean Marine Research Centre (CMRC) and another one near Bock Cay. Over-saturation of CO2 with respect to atmospheric equilibrium was observed systematically at the three sites, although significantly more marked at Norman’s Pond. The higher values of pCO2 and atmospheric CO2 fluxes obtained at Norman’s Pond, than in the adjacent open waters of the Great Bahama Bank, suggest a comparatively stronger heterotrophy at Norman’s Pond. This is most likely related to the organic carbon inputs to the water column and sediments from the dense mangrove forest surrounding Norman’s Pond. The larger amplitude of pCO2 daily variations observed, during the Norman’s Pond 24 h cycles, is probably due to higher biological activity than in the adjacent open waters of the Great Bahama Bank. This is corroborated by a tentative estimation of Gross Primary Production based on simple computations. We speculate that calcification could also contribute to some extent to different amplitude of the pCO2 daily variations between the mangrove pond and the open waters of the Great Bahama Bank. [less ▲]

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See detailSupplemental oxygen does not reduce postoperative nausea and vomiting after thyroidectomy
Joris, Jean ULiege; Poth, N. J.; Djamadar, A. M. et al

in British Journal of Anaesthesia (2003), 91(6), 857-61

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See detailL’enseignement universitaire demain. Le cas de la Belgique francophone
Merenne-Schoumaker, Bernadette ULiege

in Géographes Associés (2003), (27), 63-65

Courte présentation de la situation de la géographie dans le monde universitaire francophone de Belgique au moment de la Réforme de Bologne

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See detailDu Séminaire de Géographie au Département de Géographie, Cent ans de géographie à l’Université de Liège, 1903-2003
Merenne-Schoumaker, Bernadette ULiege

in Bulletin de la Société Géographique de Liège (2003), (43), 3-17

100-year history of teaching and research in geography at the University of Liege

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See detailLa Société géographique de Liège
Merenne-Schoumaker, Bernadette ULiege

in Bulletin de la Société Géographique de Liège (2003), (43), 185-194

75-year history of the Geographical Society of Liege

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See detailLa servitude légale d'enclave : un tour d'horizon
Boufflette, Sophie ULiege

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2003)

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See detailInfluence of a nonlinear reference temperature profile on oscillatory Benard-Marangoni convection.
Dondlinger, M.; Colinet, P.; Dauby, Pierre ULiege

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2003), 68(6 Pt 2), 066310

We analyze oscillatory instabilities in a fluid layer of infinite horizontal extent, heated from above or cooled from below, taking into account the nonlinearity of the reference temperature profile ... [more ▼]

We analyze oscillatory instabilities in a fluid layer of infinite horizontal extent, heated from above or cooled from below, taking into account the nonlinearity of the reference temperature profile during the transient state of heat conduction. The linear stability analysis shows that a nonlinear reference temperature profile can have a strong effect on the system, either stabilizing or destabilizing, depending on the relative importance of buoyancy and surface tension forces. For the nonlinear analysis we use a Galerkin-Eckhaus method leading to a finite set of amplitude equations. In the two-dimensional (2D) case, we show the solution of these amplitude equations are standing waves. [less ▲]

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See detailFin de législature: le point sur l'autonomie fiscale des communautés et des régions
Bourgeois, Marc ULiege

in Comptabilité et Fiscalité Pratiques (2003)

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See detailRecognizing and interpreting the fossils of early eukaryotes
Javaux, Emmanuelle ULiege; Knoll, A. H.; Walter, M.

in Origins of Life & Evolution of the Biosphere (2003), 33(1), 75-94

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context ... [more ▼]

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context of early eukaryotic diversification. For this reason, recognition of eukaryotic fossils in Proterozoic rocks is key to the integration of geological and comparative biological perspectives on protistan evolution. Microfossils preserved in shales of the ca. 1500 Ma Roper Group, northern Australia, display characters that ally them to the Eucarya, but, at present, attribution to any particular protistan clade is uncertain. Continuing research on wall ultrastructure and microchemistry promises new insights into the nature and systematic relationships of early eukaryotic fossils. [less ▲]

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See detailLa cartographie et la géomatique
Donnay, Jean-Paul ULiege

in Bulletin de la Société Géographique de Liège (2003), 43

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See detailWithin-herd effects of age at test day and lactation stage on test-day yields
Bormann, J.; Wiggans, G. R.; Druet, Tom ULiege et al

in Journal of Dairy Science (2003), 86(11), 3765-3774

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve ... [more ▼]

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve the accuracy of estimation. Test-day data starting with 1990 calvings for the entire US Jersey population and Holsteins from California, Pennsylvania, Wisconsin, and Texas were analyzed. Test-day yields were adjusted for across-herd effects using solutions from a regional analysis. Estimates of the relative variance ( fraction of total variance) due to within-herd age effects were small, indicating that regional adjustments for age were adequate. The relative variances for within-herd lactation stage were large enough to indicate that accuracy of genetic evaluations could be improved by including herd stage effects in the model for milk, fat, and protein, but not for somatic cell score. Because the within-herd lactation stage effect is assumed to be random, the effect is regressed toward the regional effects for small herds, but in large herds, lactation curves become herd specific. Model comparisons demonstrated the greater explanatory power of the model with a within-herd-stage effect as prediction error standard deviations were greater for the model without this effect. The benefit of the within-herd-stage effects was confirmed in a random regression model by comparing variance components from models with and without random within-herd regressions and through log-likelihood ratio tests. [less ▲]

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See detailRegulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Mottet, Denis ULiege; Dumont, Valery; Deccache, Yann et al

in Journal of Biological Chemistry (2003), 278(33), 31277-85

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms ... [more ▼]

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms involving stabilization of HIF-1alpha, phosphorylations, modifications of redox conditions, and interactions with coactivators. However, it appears that some of these steps can be cell type-specific. Among them, the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in the regulation of HIF-1 by hypoxia remains controversial. Here, we investigated the activation state of PI3K/Akt/glycogen synthase kinase 3beta (GSK3beta) in HepG2 cells. Increasing incubation times in hypoxia dramatically decreased both the phosphorylation of Akt and the inhibiting phosphorylation of GSK3beta. The PI3K/Akt pathway was necessary for HIF-1alpha stabilization early during hypoxia. Indeed, its inhibition was sufficient to decrease HIF-1alpha protein level after 5-h incubation in hypoxia. However, longer exposure (16 h) in hypoxia resulted in a decreased HIF-1alpha protein level compared with early exposure (5 h). At that time, Akt was no longer present or active, which resulted in a decrease in the inhibiting phosphorylation of GSK3beta on Ser-9 and hence in an increased GSK3beta activity. GSK3 inhibition reverted the effect of prolonged hypoxia on HIF-1alpha protein level; more stabilized HIF-1alpha was observed as well as increased HIF-1 transcriptional activity. Thus, a prolonged hypoxia activates GSK3beta, which results in decreased HIF-1alpha accumulation. In conclusion, hypoxia induced a biphasic effect on HIF-1alpha stabilization with accumulation in early hypoxia, which depends on an active PI3K/Akt pathway and an inactive GSK3beta, whereas prolonged hypoxia results in the inactivation of Akt and activation of GSK3beta, which then down-regulates the HIF-1 activity through down-regulation of HIF-1alpha accumulation. [less ▲]

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See detailSynopsis des dermatomycoses invasives chez l'immunodéprimé.
Quatresooz, Pascale ULiege; Arrese Estrada, Jorge ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2003), 58(11), 690-4

The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These ... [more ▼]

The immune system plays a prominent role in the defense against a wide variety of pathogen fungi. Thus, the immunocompromised patient becomes a potential victim of mycoses originating from the skin. These mycoses may become invasive and a fatal issue is possible. In other circumstances, the inoculation site is pulmonary or digestive, and the cutaneous lesions represent secondary localizations. [less ▲]

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See detailLe cas clinique du mois. Masse médiastinale antérieure chez une patiente acromégale.
Laret, Vinciane ULiege; Valdes Socin, Hernan Gonzalo ULiege; Betea, Daniela ULiege et al

in Revue Médicale de Liège (2003), 58(12), 724-728

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the ... [more ▼]

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the first diagnostic step consists of finding the etiology of the disease in order to use adequate treatment. This can be complicated by the fact that acromegaly can be associated with other tumors (for instance in MEN-1 disease and Carney Complex) and because chronic GH hypersecretion can stimulate tumor overgrowth and perhaps tumor formation. We describe the case of a 44-year-old acromegalic woman with an anterior mediastinal mass. We present the different diagnoses and a review of the literature. [less ▲]

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See detailAutoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: A prospective cohort study
Vermeire, S.; Noman, M.; Van Assche, G. et al

in Gastroenterology (2003), 125(1), 32-39

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and ... [more ▼]

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and the relationship with autoimmunity have not been investigated. We investigated the occurrence of antinuclear antibodies in 125 consecutive Crohn's disease patients and studied the relationship with symptoms of autoimmunity. Methods: Autoantibodies and clinical data were investigated before and 1, 2, and 3 months after infliximab infusion. If antinuclear antibodies were greater than or equal to1:80, further study of double-stranded DNA, single-stranded DNA, histones, and ENA was performed. Results: Cumulative antinuclear antibody incidence at 24 months was 71 of 125 (56.8%). Almost half of these patients developed antinuclear antibodies after the first infusion, and >75% became antinuclear antibody positive after fewer than 3 infusions. So far, only :15 of 71 patients have become seronegative, after a median of 12 months. Of 43 antinuclear antibody-positive patients who were further subtyped, 14 of 43 (32.6%) had double-stranded DNA, 17 (39.5%) had single-stranded DNA, 9 (20.9%) had antihistone, and 0% were ENA positive. Two patients (both antihistone and double-stranded DNA positive) developed drug-induced lupus without major organ damage, and I developed autoimmune hemolytic anemia. Antinuclear antibodies were associated with the female sex (odds ratio, 3.166; 95% confidence interval, 1.167-8.585; P = 0.024) and with papulosquamous or butterfly rash (odds ratio, 10.016; 95% confidence interval, 1.708-58.725; P = 0.011). Conclusions: The cumulative incidence of antinuclear antibodies was 56.8% after 24 months in this cohort of infliximab-treated Crohn's disease patients. Antinuclear antibodies persisted up to I year after the last infusion, and only a few patients became seronegative. Two patients developed drug-induced lupus erythematosus. Antinuclear antibodies were associated with the female sex and skin manifestations. [less ▲]

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See detailFormation continue en jonglerie
Fischbach, Willi; Cloes, Marc ULiege

in Revue de l'Education Physique (2003), 43(4), 114-125

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de ... [more ▼]

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de formations continuées proposées aux maîtres de stage qui collaborent à la formation des étudiants de l’AESS de l’Institut Supérieur d’Education Physique et de Kinésithérapie de l’ULg. [less ▲]

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See detailLa géographie appliquée à l’université de Liège
Binard, Marc ULiege; Devillet, Guénaël ULiege; Erpicum, Michel ULiege

in Bulletin de la Société Géographique de Liège (2003), 43

Historic of the applied geography within the various units of the Geographic Department of the University of Liège (Belgium)

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See detailProstatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation.
Cornet, Anne ULiege; Hanon, Emmanuel; Reiter, Eric R et al

in Prostate (The) (2003), 56(3), 220-30

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen ... [more ▼]

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen withdrawal. The regulation of PARM-1 by androgens is limited to this organ. We have studied the effects of PARM-1 overexpression in malignant prostate cells. METHODS: The PARM-1 cDNA was introduced into the rat cancer cell line MAT LyLu along with a doxycycline-dependent regulator. RESULTS: Maximal expression of PARM-1 (fivefold induction) was achieved by incubating the cells with 2 microM doxycycline for 48 hr. A study investigating the effect of PARM-1 overexpression on the transcription of 588 genes has shown that the TLP1 gene (encoding rat telomerase protein component 1) was the most up-regulated (fourfold). In addition, a dose-dependent increase in telomerase activity was observed in cells overexpressing PARM-1. In vivo, the androgen-deprived prostate showed an increased TLP1 level and increased telomerase activity. CONCLUSIONS: Increased telomerase activity is often associated with the immortalisation of cancer cell lines, particularly prostatic ones. This could mean that PARM-1 is involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells. [less ▲]

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See detailL'assurance dépendance: quels risques à assurer?
Jousten, Alain ULiege

in Risques (2003), 55

La perte d'autonomie est un thème d'actualité dans bon nombre de pays développés, notamment vu le processus de vieillissement démographique qui est en cours. Malgré ce constat commun à la majeure partie ... [more ▼]

La perte d'autonomie est un thème d'actualité dans bon nombre de pays développés, notamment vu le processus de vieillissement démographique qui est en cours. Malgré ce constat commun à la majeure partie des pays, les réponses apportées ou proposées dans les différents pays semblent différer de façon fondamentale. Nous proposons différentes classifications qui permettent de mieux comprendre les enjeux quant à l'étendue et le financement des prestations couvertes par les systèmes d'assurance dépendance. [less ▲]

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See detailImage analysis of PM powders adds a new dimension
Pirard, Eric ULiege

in Metal Powder Report (2003)

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See detailSpasmogenic action of endothelin-1 on isolated equine pulmonary artery and bronchus
Benamou, A. E. M.; Marlin, D. J.; Callingham, B. C. et al

in Equine Veterinary Journal (2003), 35(2), 190-6

Reasons for performing study: There is currently little published information about the effects of endothelin-1 (ET-1), a potent endogenous spasmogen of vascular and airway smooth muscle, on pulmonary ... [more ▼]

Reasons for performing study: There is currently little published information about the effects of endothelin-1 (ET-1), a potent endogenous spasmogen of vascular and airway smooth muscle, on pulmonary vasculature and airways or which ET receptor subtypes mediate ET-1 induced vasoconstrictive and bronchoconstrictive action in the horse. Objectives: To investigate the effect of endothelin-1 (ET-1) on smooth muscle from isolated equine pulmonary artery and bronchus. In addition, the roles of ETA and ETB receptors in ET-1 mediated contraction in these tissues were assessed. Methods: The force generation of ring segments from pulmonary arteries or third-generation airways (obtained from horses subjected to euthanasia for orthopaedic reasons) were studied in an organ bath at 37°C in response to exogenous endothelin and selective endothelin A (BQ123) or B receptor (BQ788) antagonists. Results: ET-1 produced concentration-dependent contractions of the equine pulmonary artery and bronchus. The threshold for contraction was 10-10 and 10-9 mol/l ET-1 for pulmonary artery and bronchus, respectively. The maximal contraction induced by the highest ET-1 concentration (10-7 mol/l) was 173 and 194% of the contraction obtained with 100 mmol/l KCl in pulmonary artery and bronchus, respectively. ET-1 potency was 25 times greater in equine pulmonary artery than in equine bronchus (concentration of ET-1 producing 50% of maximal contraction [EC50] = 5.6 10-9 mol/l and 2.2 10-8 mol/l, respectively). In pulmonary artery, ET-1 induced contractions were significantly inhibited by the ETA receptor antagonist BQ123 (1 μmol/l; dose-response curve to ET-1 was shifted to the right by 5.4-fold), but not by the ETB antagonist BQ788. In bronchus, dose-responses curves to ET-1 were shifted to the right by BQ123 (1 μmol/l; 2.5-fold), but not by BQ788 (1 μmol/l). In the presence of both antagonists, the dose-response curve to ET-1 was shifted to the right by 4.5-fold. Conclusions: These functional studies demonstrate that ET-1 is a potent spasmogen of equine third generation pulmonary artery and bronchus, and that contractions are mediated via ETA receptors in the former and both ETA and ETB receptors in the latter. Potential clinical relevance: Endothelin receptor antagonists may have potential for treating equine pulmonary hypertension or bronchoconstriction. [less ▲]

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See detailQuand l’employeur ne respecte pas les barèmes de rémunération
Kefer, Fabienne ULiege

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2003), (8/9), 22-26

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See detailDépart à la retraite: une perspective internationale
Jousten, Alain ULiege

in Revue Française d'Economie (2003), XVIII

Des différences internationales importantes persistent quant au taux d'activité des travailleurs âgés et à l'âge du départ à la retraite. Tandis que certains pays d'Europe continentale sont caractérisés ... [more ▼]

Des différences internationales importantes persistent quant au taux d'activité des travailleurs âgés et à l'âge du départ à la retraite. Tandis que certains pays d'Europe continentale sont caractérisés par des taux d'activités relativement faibles, d'autres pays développés ne connaissent pas cette tendance. Nous illustrons le rôle important joué par les décisions individuelles dans le contexte du départ à la retraite. [less ▲]

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See detailThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
Valdes Socin, Hernan Gonzalo ULiege; Chanson, Philippe; Delemer, B. et al

in European Journal of Endocrinology (2003), 148(4), 433-442

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 ... [more ▼]

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 male and 20 female) among 4400 pituitary adenomas followed between 1976 and 2001 in six Belgian and French centers. RESULTS: TSH was elevated in 18/43 and alpha subunit in 13/32 patients. In patients with intact thyroid (n=30), mean free tri-iodothyronine was 13.1 pmol/l (range 3.5-23) and mean free thyroxine was 38.4 pmol/l (range 10.2-62.7). Hyperprolactinemia and acromegaly were associated in 9/43 and 8/43 cases. The number of associated hypersecretions was higher in macroadenomas than in microadenomas (Chi square = 11.2, P<0.01). Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome. The proportion of microadenomas versus macroadenomas was 1/11 (period 1974-1986) and 8/32 (period 1987-2001). Bilateral petrosal sinus sampling, (111)In-pentreotide scintigraphy and ((11)C)-l-methionine positron emission tomography scan confirmed diagnosis in four questionable microadenomas. Macroadenomas with extrasellar extension (31 cases) had a tendency to be medially located. Medical treatment with somatostatin analogs was initiated as first-line treatment in 26 patients. TSH levels were reduced by more than 50% in 23/26 cases. A tumoral shrinkage of more than 20% was observed in 5/13 cases. Surgery was performed in 36 patients. After 1 year, 21 of them (58.3%) met the criteria of surgical favorable outcome. Pituitary radiotherapy (n=8) and somatostatin analogs allowed normalization in cases not cured by surgery. CONCLUSION: Ultrasensitive methods for TSH measurement led to an earlier recognition of TSH-secreting pituitary tumors. In this series, we observed that TSH-secreting pituitary tumors are today more frequently found at the stage of microadenomas, medially located, without associated hypersecretions and needing new exploration methods as compared with older series. This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease. [less ▲]

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See detailAnalyse de la cessation d'activité en Belgique
Jousten, Alain ULiege; Dellis, A.; Desmet, R. et al

in Revue Française d'Economie (2003), XVIII

L’objectif de cette étude est de montrer l’influence du système de retraite sur la cessation d’activité. La première étape consiste à estimer les incitations financières implicites à ce système et ensuite ... [more ▼]

L’objectif de cette étude est de montrer l’influence du système de retraite sur la cessation d’activité. La première étape consiste à estimer les incitations financières implicites à ce système et ensuite à les introduire comme variables explicatives du départ à la retraite dans une régression de type probit. Le résultat majeur de cette contribution est d’indiquer le rôle significatif de ces incitations sur les décisions individuelles. La seconde étape consiste à utiliser les résultats de cette modélisation pour analyser l’effet de réformes sur la prolongation de l’activité. Il apparaît que l’aménagement de certaines règles d’octroi et de calcul des pensions pourrait inciter les travailleurs âgés à différer l’âge de leur retraite. [less ▲]

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