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See detailComparaison empirique des estimateurs des taux d'erreur en analyse discriminante
Glele Kakai, R.; Piraux, F.; Fonton, N. H. et al

in Revue de Statistique Appliquée (2003), LI(3), 61-74

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi ... [more ▼]

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi-square and beta) have been considered. Estimators eOS (for actual and expected error rate) and eB (for optimal error rate) are the best, except for distributions very different from normal distributions. The e632 estimator is the best non parametric estimator. This estimator is better than parmetric estimators for distributions very different from normal distributions. [less ▲]

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See detailInteraction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Twizere, Jean-Claude ULiege; Kruys, Veronique; Lefebvre, Laurent et al

in Journal of the National Cancer Institute (2003), 95(24), 1846-59

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell ... [more ▼]

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell leukemia viruses and bovine leukemia virus). To better understand the molecular pathways leading to cell transformation, we aimed to identify cellular proteins interacting with Tax. METHODS: We used a yeast two-hybrid system to identify interacting cellular proteins. Interactions between Tax and candidate interacting cellular proteins were confirmed by glutathione S-transferase (GST) pulldown assays, co-immunoprecipitation, and confocal microscopy. Functional interactions between Tax and one interacting protein, tristetraprolin (TTP), were assessed by analyzing the expression of tumor necrosis factor-alpha (TNF-alpha), which is regulated by TTP, in mammalian cells (HeLa, D17, HEK 293, and RAW 264.7) transiently transfected with combinations of intact and mutant Tax and TTP. RESULTS: We obtained seven interacting cellular proteins, of which one, TTP, was further characterized. Tax and TTP were found to interact specifically through their respective carboxyl-terminal domains. The proteins colocalized in the cytoplasm in a region surrounding the nucleus of HeLa cells. Furthermore, coexpression of Tax was associated with nuclear accumulation of TTP. TTP is an immediate-early protein that inhibits expression of TNF-alpha at the post-transcriptional level. Expression of Tax reverted this inhibition, both in transient transfection experiments and in stably transfected macrophage cell lines. CONCLUSION: Tax, through its interactions with the TTP repressor, indirectly increases TNF-alpha expression. This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis. [less ▲]

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See detailTotaal cardiovasculair risico: HOPE doet langer leven!
Krzesinski, Jean-Marie ULiege

in Tempo Médical (2003), 247

Cardiovasculaire aandoeningen blijven de belangrijkste doodsoorzaak bij volwassenen. Dat onderstreept het belang van een adequate behandeling van het risico, met name in de algemene geneeskunde. Oe meest ... [more ▼]

Cardiovasculaire aandoeningen blijven de belangrijkste doodsoorzaak bij volwassenen. Dat onderstreept het belang van een adequate behandeling van het risico, met name in de algemene geneeskunde. Oe meest recente aanbevelingen gaan steeds meer in de zin van een aanpak van het totale cardiovasculaire risico, waarbij minder belang wordt gehecht aan de absolute waarde van de atzonderlijke risicotactoren. Patienten met het grootste totale risico moeten uiteraard prioritair behandeld worden. Deze houding is gebaseerd op de resultaten van enkele grote klinische studies, waaronder HOPE (Heart Outcomes Prevention Evaluation). In dit artikel krijgt u een overzicht van de resultaten van deze opmerkelijke studie en een commentaar op deze nieuwe preventieve aanpak van het cardiovasculaire risico in het gezelschap van enkele sprekers op het congres Cardio 2003. [less ▲]

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See detail« ‘Soñar, recordar y vivir con eso’. Los sueños de los Záparas en la construcción del pasado, Amazonia Ecuatoriana »,
Bilhaut, Anne-Gaël ULiege

in Estudios Atacameños (2003), 26

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental ... [more ▼]

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental role in their daily life. We will see how their history is constructed by means of dream experiences, and how these are used strategically in the present. Dreams, furthermore, guarantee the cultural and ritual continuity of this group on the verge of extinction. [less ▲]

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See detailRisque cardiovasculaire global: HOPE fait vivre plus longtemps
Krzesinski, Jean-Marie ULiege

in Tempo Médical (2003), 247

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les ... [more ▼]

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les recommandations les plus récentes vont de plus en plus dans le sens d'une prise en charge du risque cardiovasculaire global, accordant moins d'importance à la valeur absolue de chacun des facteurs de risque; les patients présentant le plus grand risque global devant, bien entendu, être prioritairement traités. Une attitude, basée sur les résultats de quelques grandes études cliniques, dont HOPE (Heart Outcomes Prevention Evaluation). Nous vous proposons ici un rappel des résultats de cette étude remarquable, ainsi qu'un commentaire sur cette nouvelle approche préventive du risque CV, en compagnie de quelques uns des orateurs du congrès Cardio 2003. [less ▲]

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See detailProlactin Suppresses Glucocorticoid-Induced Thymocyte Apoptosis in Vivo
Krishnan, Nithya; Thellin, Olivier ULiege; Buckley, Donna J. et al

in Endocrinology (2003), 144(5), 2102-2110

The hypothesis that prolactin (PRL) functions as an immunomodulator was based on studies showing lymphocyte PRL receptors, and its effects on growth, differentiation, and apoptosis in lymphoid cells ... [more ▼]

The hypothesis that prolactin (PRL) functions as an immunomodulator was based on studies showing lymphocyte PRL receptors, and its effects on growth, differentiation, and apoptosis in lymphoid cells. However, studies of PRL (PRL-/-) and PRL receptor knockout mice indicated that PRL was not required for immune system development or function under basal conditions. Because PRL maintains survival in glucocorticoid (GC)-treated Nb2-T lymphocytes in vitro, and PRL and GCs are elevated during stress, we investigated whether PRL protected T cells in vivo from GC-induced apoptosis. Adrenalectomized mice [PRL -/-, undetectable PRL; pituitary grafted PRL-/- (PRL-/-Graft), elevated PRL; and PRL+/-, normal PRL] were treated with dexamethasone (DEX) or PBS. Thymocytes and splenocytes were isolated and annexin V labeling of phosphatidylserine, DNA fragmentation, and caspase-3 activation were assessed as indices of apoptosis. Total thymocytes and CD4+ and CD8+ T cells obtained from DEX-treated PRL-/- mice exhibited significantly increased annexin V binding. In contrast, binding was not altered by DEX in PRL-/-Graft thymocytes. In addition, DEX induced classic DNA fragmentation in PRL-/- thymocytes. Elevated serum PRL reduced this effect. Thymocytes from DEX-treated PRL-/- mice exhibited increased caspase-3 activation, which was inhibited in cells from PRL-/-Graft mice. Finally, elevated expression of X-linked inhibitor of apoptosis, XIAP, was observed in thymi from DEX-treated PRL -/-Graft mice. This is the first demonstration that elevated PRL antagonizes apoptosis in thymocytes exposed to GCs in vivo. These observations suggest that, under conditions of increased GCs, such as during stress, elevated PRL functions physiologically to maintain survival and function of T-lymphocytes. [less ▲]

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See detailFunctional neuroimaging of auditory processing
Laureys, Steven ULiege; Salmon, Eric ULiege; Goldman, Serge et al

in Acta Oto-Rhino-Laryngologica Belgica (2003), 57(4), 267-273

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm ... [more ▼]

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm the spatial distribution of brain activation in temporal areas for the processing of simple acoustic stimuli. Brain activity is much more complex for words, and different networks can be recruited when phonological, lexical and semantic levels of processing are engaged. [less ▲]

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See detailL’herpèsvirus bovin 4
Markine-Goriaynoff, N.; Minner, F.; De Fays, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 215-247

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a ... [more ▼]

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a worldwide distribution in the cattle population. It has been isolated from cattle showing various clinical signs as well as from healthy cattle. The interest of the scientific community for BoHV-4 is explained by two reasons. Firstly, BoHV-4 represents an homologous virus/host species model to study the biology of gammaherpesviruses. Secondly, the use of BoHV-4 as a recombinant vector for expression both in vitro and in vivo has been proposed. For these reasons, a considerable amount of data has been collected on this virus. In the present paper, the authors will present a general overview of the literature published on this virus addressing clinical, epidemiological and fundamental aspects of BoHV-4. Finally, in the light of their recent phylogenetic data, the authors will discuss the origin and the host species of BoHV-4 leading to the conclusion that this virus should be considered as a virus of the African buffalo rather than cattle. [less ▲]

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See detailMitochondrial phylogeography of the Woodmouse (Apodemus sylvaticus) in the Western Palearctic region.
Michaux, Johan ULiege; Magnanou, E.; Paradis, E. et al

in Molecular Ecology (2003), 12(3), 685-97

We sequenced 965 base pairs of the mitochondrial DNA cytochrome b from 102 woodmice (Apodemus sylvaticus) collected from 40 European localities. The aims of the study were to answer the following ... [more ▼]

We sequenced 965 base pairs of the mitochondrial DNA cytochrome b from 102 woodmice (Apodemus sylvaticus) collected from 40 European localities. The aims of the study were to answer the following questions. (i) Did the Mediterranean peninsulas play a role as refuge for woodmice? (ii) Is genetic variability of A. sylvaticus higher in the Mediterranean region compared with northern Europe? (iii) Are the patterns of the postglacial colonization of Europe by woodmice similar to those presently recognized for other European species? The results provide a clear picture of the impact of the Quaternary glaciations on the genetic and geographical structure of the woodmouse. Our analyses indicate a higher genetic variability of woodmice in the Mediterranean peninsulas compared to northern Europe, suggesting a role of the former as refuge regions for this small mammal. An original pattern of postglacial colonization is proposed where the Iberian and southern France refuge populations colonized almost all European regions. The Sicilian population appears to be very differentiated and highly variable. This emphasizes the importance of this island as a 'hot spot' for the intraspecific genetic diversity of the woodmouse. Finally, woodmice in North Africa originated from southwestern Europe, most probably as a result of a recent anthropogenic introduction. [less ▲]

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See detailLa peau de l'acromégale.
Hermanns-Lê, Trinh ULiege; QUATRESOOZ, Pascale ULiege; Arrese Estrada, Jorge ULiege et al

in Dermatologie Actualité (2003), 75

L'acromégalie est l'expression clinique d'une hypersécrétion chronique de l'hormone de croissance dont la source est, dans la plupart des cas, un adénome hypophysaire. Son diagnostic est souvent posé ... [more ▼]

L'acromégalie est l'expression clinique d'une hypersécrétion chronique de l'hormone de croissance dont la source est, dans la plupart des cas, un adénome hypophysaire. Son diagnostic est souvent posé tardivement, car les signes cliniques se développent de façon insidieuse. [less ▲]

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See detailModèle de croissance pour les plantations de mélèzes.
Pauwels, D.; Lejeune, Philippe ULiege; Rondeux, Jacques ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(2), 87-97

A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches ... [more ▼]

A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches (Japanese, European and Hybrid larches) in 99 stands. It enables to predict tree circumference increment from circumference, dominant height, basal area, age and site index of stands. Estimating increments of 1283 larches in 48 stands has been used to validate the model that gives unbiased estimates of the increments (mean error = -0.002 cm with standard deviation of 0.60 cm). The mean absolute error of estimates is 0.46 cm.year-1. The model has also been tested to predict the increment of larches in French experimental plots having very different silvicultural treatments. The residues of these estimations depend on the stand basal area: the lesser the stand basal area, the higher the residues of the estimation. A correction factor, linked to basal area through a Bailey and Clutter curve, has been introduced to extend the validity of the model to stands with a basal area lower than 12 m2.ha-1. This factor does not affect the increment estimations if the stand characteristics are close to mean value of the sample used to build the model (correction factor close to 1). The introduction in the model of competition indexes distance dependant or site qualitative variables does not significantly improve the growth model. [less ▲]

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See detailEpisode de dyspnée consécutive à une intoxication par l’ergot dans une exploitation laitière
Brihoum, Mounir ULiege; Desmecht, Daniel ULiege; Bony, S. et al

in Annales de Médecine Vétérinaire (2003), 147(5), 353-358

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These ... [more ▼]

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These troubles can be compared to many observations done in humans after long lasting treatments with ergot derivatives [less ▲]

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See detailEffet de la géométrie et de la disposition des mobiles d'agitation sur la formation de mousse en cuve agitée
Delvigne, Frank ULiege; Bruxelmane, Marc; Thonart, Philippe ULiege

in Tribune de l'Eau (La) (2003), 622(2), 65-70

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See detailLa maladie du hêtre en Région wallonne : état des lieux chiffré de 2001 à 2003
Rondeux, Jacques ULiege; Huart, O.; Lecomte, H. et al

in Silva Belgica (2003), 110(3), 18-28

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See detailA dip into the world of veterinary nuclear medicine: equine lung scintigraphy
Votion, Dominique ULiege; Lekeux, Pierre ULiege

in Clinical Techniques in Equine Practice (2003), 2(3), 222-230

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology ... [more ▼]

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology, for the knowledge of animal peculiarities, for the study and diagnosis of equine respiratory disorders as well as for the development of their treatment. This article surveys some methodological constraints due to the scanning of a noncooperative large-sized animal, reviews the contribution of equine nuclear imaging in lung physiology and pathology, and discusses future clinical and fundamental applications of lung scintigraphy. [less ▲]

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See detailIntroduction of australian diploid cotton genetic variation into upland cotton
Ahoton, L.; Lacape, Jm.; Baudoin, Jean-Pierre ULiege et al

in Crop Science (2003), 43(6), 1999-2005

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailModélisation 3D d’un groupe de pieux pour le pont-canal de Houdeng
Trevisan, Stefano; Li, Xian Ling; Collin, Frédéric ULiege et al

in Revue Française de Géotechnique (2003), 105

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group ... [more ▼]

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group of piles and to the quality of the drilled piles of the canal-bridge of Houdeng (Belgium) are analysed in a non conventional fashion, based on a finite element analysis, thanks to sufficient experimental data. The influence of an imperfectly cleaned excavation bottom and of the destructuration of the bottom rocks caused by the drilling of the piles is investigated. A particular attention is also given to the behaviour of a group of piles. [less ▲]

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See detailIndole alkaloids from Strychnos species and their antiplasmodial and cytotoxic activities
Frederich, Michel ULiege; Tits, Monique ULiege; Angenot, Luc ULiege

in Chemistry of Natural Compounds (2003), 39(6, NOV-DEC), 513-519

Strychnos species (Loganiaceae) have been studied in the laboratory of Pharmacognosy of the University of Liege for more than fifty years. Although investigations into the Strychnos genus have been going ... [more ▼]

Strychnos species (Loganiaceae) have been studied in the laboratory of Pharmacognosy of the University of Liege for more than fifty years. Although investigations into the Strychnos genus have been going on for a long time in the case of Asian tetanizing and American curarizing species, the first chemical and pharmacological screening on African species was undertaken in the early nineteen fifties by the late Prof A. Denoel (University of Liege, Belgium), who examined twenty-five species of Strychnos collected in the Belgian Congo [1]. This research programme was also an offshoot of an inventory of medicinal and toxic plants in Rwanda, carried out during the years 1969-1970. The Belgian scientists were lucky to observe the tribe of Banyambo, living along the Akagera river on the border between Rwanda and Tanzania, where hunters prepared in front of them an arrow poison with Strychnos usambarensis roots and leaves as the main ingredients [2]. Strychnos species have several ethnobotanical uses. A few species are well known for their incorporation into arrow and ordeal poisons, but play more a role in ethnomedicine against fever, rheumatism, worms, ulcers, leprosy, snake-bites, and so forth [3]. In fact, among about one hundred and ninety species, only six would contain strychnine (1) (Strychnos nux-vomica L. [4-7], S. ignatii P. Bergius [8, 9], and S. wallichiana Steud ex DC. [7, 10] from Asia, S. lucida R. Br. [7, 11] from Australia, S. icaja Baillon [1, 12] from Africa, and S. panamensis [13-15] from South America). Strychnos alkaloids are in fact an example of molecular and pharmacological biodiversity. More than 300 different Strychnos alkaloids have been isolated to date and theypresent various biological activities in several fields: parasitology (amoebiasis, paludism, etc.) [ 16-18], cancer [ 19-22], neurology (tetanizing or curarizing effects) [14, 23, 24-26], inflammation [27], and so on. [less ▲]

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See detailPostexposure management of hepatitis A, B or C: treatment, postexposure prophylaxis and recommendations
Delwaide, Jean ULiege

in Acta Gastro-Enterologica Belgica (2003), 66(3), 250-254

Although there is no consensus on the best management of acute hepatitis C or on optimal strategy of follow-up after potential contamination, certain guidelines can nevertheless be proposed for the care ... [more ▼]

Although there is no consensus on the best management of acute hepatitis C or on optimal strategy of follow-up after potential contamination, certain guidelines can nevertheless be proposed for the care of these patients in practice. It is now recommended that acute hepatitis C be treated by interferon monotherapy in the presence of a C viremia, detectable by polymerase chain reaction, and an elevation of the transaminases. The earlier the treatment is started after appearance of symptoms, the more effective it is. Management of a potentially contaminated individuals consists of screening for the C virus as early as the fifteenth day after the potentially contaminating act and, in the case of virus transmission, starting interferon treatment as soon as elevation of the transaminases appears. No special precautions are to be taken by the person potentially contaminated for avoiding possible secondary C virus transmission during the follow-up period. In the case of acute hepatitis B, antiviral treatment should not be started, in view of the high percentage of spontaneous recoveries and the potentially negative effect of treatment on the chances of spontaneous recovery. Post-exposure prophylaxis by anti-hepatitis B immunoglobin injections and/or vaccination should be considered after evaluation of the hepatitis B surface antigen status of the source and of the vaccination and vaccine-response status of the exposed person. The classic scheme for selecting the most appropriate postexposure prophylaxis is reminded. In post-exposure prophylaxis for hepatitis A virus, although there have been no studies comparing the effectiveness of vaccination with that of immunoglobin injections, it is at present proposed to provide only vaccination. The target groups eligible for post-exposure prophylaxis are evoked. [less ▲]

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See detailInduce triploidy by heat shock in Eurasian perch, Perca fluviatilis
Rougeot, Carole ULiege; Minet, Laurent; Prignon, Christian ULiege et al

in Aquatic Living Resources (2003), 16(2, MAR-APR), 90-94

In Eurasian perch (Perca fluviatilis), females grow significantly faster than males. Moreover, gonadal development has a significant negative impact on somatic growth and fillet yield. In order to induce ... [more ▼]

In Eurasian perch (Perca fluviatilis), females grow significantly faster than males. Moreover, gonadal development has a significant negative impact on somatic growth and fillet yield. In order to induce sterility, triploidy induction was attempted by subjecting fertilised eggs to heat shocks. Different combinations of temperature (28, 30, 34, 35 and 36 degreesC), duration (2, 5, 10 and 25 min) and time of shock initiation (TI = 3, 5 and 7 min post-fertilisation) were tested. Flow cytometry analysis was used to assess ploidy level of control and heat-shocked larvae. Low intensity (28-30 degreesC) and long duration (10 and 25 min) shocks lead to significantly higher survival (44 +/- 26%) and triploidisation (71 +/- 26%) rates than high intensity (34-36 degreesC) and short duration (2 and 5 min) shocks (17 +/- 19% and 21 +/- 26%, respectively). The most effective conditions for efficient triploidy induction were low intensity shock of 30 degreesC, applied 5 min post-fertilisation for 25 min. This treatment led to the production of all-triploid populations (100%) with up to 43% survival rate. (C) 2003 Editions scientifiques et medicales Elsevier SAS and Ifremer/IRD/Inra/Cemagref. All rights reserved. [less ▲]

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See detailLes protéines de choc thermique (heat shock proteins). II Les protéines de choc thermique (heat shock proteins). II. Hsp70, biomarqueur, bioprotecteur.
Wirth, Delphine; Gustin, Pascal ULiege; Drion, Pierre ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(2), 127-144

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was ... [more ▼]

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was initially discovered in Drosophila. The genes hsps were among the first eukaryotic genes to be cloned and whose regulation, which involves activation of heat shock factor (HSF), was elucidated. More recently, study of Hsp functions, particularly Hsp70, started. Their protective role, related to their molecular chaperon function, was inferred from experiments showing that Hsp70 expression, induced by a first stress, results in a cellular tolerance to second stress. Better understanding of the heat shock response had led to the development of two search fields on Hsp70 expression : (1) its use as biomarker of cellular stress and (2) the exploitation of its cytoprotective functions against various insults. This review includes historic of the research on the heat shock response, description of regulation mechanism of Hsp70 expression, and the interesting perspectives allocated to Hsp70 as biomarker and therapeutic tool. ----------- L’exposition de tout organisme à des températures élevées induit l'expression cellulaire rapide et transitoire de protéines spécifiques, les protéines de choc thermique (Hsps pour " heat shock proteins "). Cette réponse des cellules au choc thermique ou " heat shock response " a été initialement découverte chez la drosophile. Les gènes hsps furent parmi les premiers gènes eucaryotes à être clonés et utilisés comme paradigme dans l'étude des mécanismes de régulation transcriptionnelle faisant intervenir l'activation d'un ou plusieurs " heat shock factors" (HSFs). C'est plus récemment que l'étude des fonctions des Hsps, particulièrement Hsp70, a débuté. Le rôle protecteur de celle-ci, lié à sa fonction de " chaperon " protéique, a été déduit d'expériences montrant que l'induction de l'expression de Hsp70 lors d'un stress était associée au développement d'une tolérance cellulaire vis-à-vis d'un stress ultérieur. En plus d'un intérêt fondamental pour la compréhension de la "réponse au choc thermique", deux axes de recherche appliquée se sont développés visant à investiguer la possibilité d'utiliser l'expression de Hsp70 comme biomarqueur de souffrance cellulaire d'une part et, d'autre part, d'exploiter ses fonctions comme moyen de protection des cellules contre divers types d'agressions. Cette revue décrit l'historique des découvertes sur la " réponse au choc thermique ", le mécanisme régulant l'expression de Hsp70 ainsi que les perspectives intéressantes s'ouvrant à l'utilisation de l'expression de Hsp70 en tant que biomarqueur et outil thérapeutique. [less ▲]

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See detailAnimal welfare: The contribution of ethology
Vandenheede, Marc ULiege

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 17-22

During the last fifty years, intensive husbandry has profoundly modified the animal living conditions, especially in pigs and poultry. At the same time, concerns about animal welfare were growing on ... [more ▼]

During the last fifty years, intensive husbandry has profoundly modified the animal living conditions, especially in pigs and poultry. At the same time, concerns about animal welfare were growing on. "Welfare " (" le bien-etre " in french) can be defined as a state of dynamic balance (homeostasy) between the animal and its environment (internal and external). The attempts of the animal to maintain or to adjust this balance may induce physical and mental sufferings, eventually harmful even on a health than on a performance point of view. Welfare of farm animals is assessed using 4 complementary and closely linked types of measures, i.e. performance, health, physiology and ethology. Ethological measurements involve a lot of advantages and are more and more utilised: study of adaptation abilities, behavioural disorders or animal motivation and preference. Ethology is thus considered as a very useful tool that can not be neglected, as shown by the important scientific work, notably in pigs and poultry. Research results have to constitute an essential prerequisite to the ethical reflection process regarding animal welfare, allowing to induce concrete and relevant political acts. [less ▲]

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See detailSHIP2 et signalisation de l'insuline: quel role dans la pathogenese et le traitement du diabete de type 2?
Schurmans, Stéphane ULiege

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2003), 158(7-9), 335-9

Based on the analysis of SHIP2+/- and SHIP2-/- mice showing that the lipid phophatase SHIP2 is an important negative regulator of the insulin pathway, we have suggested that the enzyme is a candidate gene ... [more ▼]

Based on the analysis of SHIP2+/- and SHIP2-/- mice showing that the lipid phophatase SHIP2 is an important negative regulator of the insulin pathway, we have suggested that the enzyme is a candidate gene for genetic predisposition to type 2 diabetes, and a potential therapeutic target for the same disease. Two years after, we propose to review these hypothesis in light of recent results from our laboratory, from international collaborations and from competitors in the field. [less ▲]

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See detailInterprétation géométrique de la régression
Iemma, A. F.; Palm, Rodolphe ULiege

in Notes de Statistique et d'Informatique (2003), (2), 1-28

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See detailOff-line processing of memory traces during human sleep: Contribution of functional neuroimaging
Maquet, Pierre ULiege; Peigneux, Philippe ULiege; Laureys, Steven ULiege et al

in Sleep & Biological Rhythms (2003), 1

Sleep is thought to participate in the consolidation of recent memory traces. We tested this hypothesis in humans by using functional neuroimaging (functional magnetic resonance imaging and positron ... [more ▼]

Sleep is thought to participate in the consolidation of recent memory traces. We tested this hypothesis in humans by using functional neuroimaging (functional magnetic resonance imaging and positron emission tomography). First, following the training procedural visuo-motor learning task (pursuit task), total sleep deprivation on the first post-training night significantly deteriorates the gain in performance, which is usually observed after one complete night of sleep. In parallel, sleep deprivation hampers the changes in functional segregation and connectivity, which underpin the gain in performance usually observed in subjects allowed to sleep on the first post-training night. Second, following the training on an implicit memory task (probabilistic serial reaction time task), some brain areas are reactivated during rapid eye movement (REM) sleep on the first post-training night. The reactivation was shown to be related to the processing of high-level material and to be modulated by the amount of learning achieved during the training session. These changes in activity do not involve isolated brain areas but entire macroscopic cortico-subcortical networks. Taken together, the results suggest an off-line processing of recent memory traces during sleep. [less ▲]

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See detailLa possible modification de la procédure de révision de la Constitution belge
Behrendt, Christian ULiege

in Revue Française de Droit Constitutionnel (2003)

The article examines the question whether it is appropriate to alter the current amendment procedure of the Belgian constitution. Furthermore, the articles enquires into the possible design of a new ... [more ▼]

The article examines the question whether it is appropriate to alter the current amendment procedure of the Belgian constitution. Furthermore, the articles enquires into the possible design of a new amendment procedure. [less ▲]

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See detailThe callipyge locus: evidence for the trans interaction of reciprocally imprinted genes
Georges, Michel ULiege; Charlier, Carole ULiege; Cockett, N.

in Trends in Genetics (2003), 19

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See detailSpinal mechanisms contribute to analgesia produced by epidural sufentanil combined with bupivacaine for postoperative analgesia
Joris, Jean ULiege; Jacob, Eric; Sessler, Daniel et al

in Anesthesia and Analgesia (2003), 97

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See detailMarocains de Belgique : du travailleur immigré au citoyen transnational
Bousetta, Hassan ULiege; Martiniello, Marco ULiege

in Hommes & Migrations (2003), 1242(Mars-Avril), 94-106

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See detailHow ergodic is the fragmentation of the pyridine cation? A maximum entropy analysis
Gridelet, E.; Locht, Robert ULiege; Lorquet, Andrée ULiege et al

in International Journal of Mass Spectrometry (2003), 228(2-3), 389-402

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the ... [more ▼]

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the reaction threshold. This extends our previous study limited to the metastable domain [Int. J. Mass Spectrom. Ion Process. 185/186/187 (1999) 155]. Retarding potential curves resulting from dissociative photoionization using the He(I), Ne(I), and Ar(II) resonance lines have been analyzed by the maximum entropy method. The comparison between the experimentally measured curves and those calculated for the prior (i.e., most statistical) situation reveals the existence of dynamical constraints that prevent phase space from being fully explored. The "ergodicity index" F(E) that measures the efficiency of phase space sampling as a function of the internal energy E of the molecular ion is found to decrease steadily as a function of E and to level off at a value of about 50% when E greater than or equal to 2.5 eV At these high internal energies where phase space exploration no longer decreases, spontaneous intramolecular vibrational energy redistribution (i.e., resulting from the anharmonicity of the molecular vibrations) is thought to contribute to internal energy randomization to a limited extent only. When the lifetime is short, phase space exploration is believed to result instead from the relaxation of the electronic energy via a cascade of non-radiative transitions, which leads to a great diversity of initial conditions, and thus, contributes to statisticity. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailVascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas.
Munaut, Carine ULiege; Noël, Agnès ULiege; Hougrand, Olivier ULiege et al

in International Journal of Cancer = Journal International du Cancer (2003), 106(6), 848-55

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of ... [more ▼]

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors (VEGFR-1, its soluble form sVEGFR-1, VEGFR-2 and neuropilin-1) are expressed predominantly by endothelial cells. Infiltrating tumour cells and newly-formed capillaries progress through the extracellular matrix by local proteolysis involving matrix metalloproteinases (MMPs). Recent studies have shown that VEGF expression and bioavailability can be modulated by MMPs. We reported previously that the expression of MT1-MMP in human breast cancer cells was associated with an enhanced VEGF expression. We used quantitative RT-PCR, Western blot, gelatin zymography and immunohistochemistry to study the expression of VEGF, VEGFR-1, VEGFR-2, sVEGFR-1, neuropilin-1, MT1-MMP, MMP-2, MMP-9 and TIMP-2 in 20 human GBMs and 5 normal brains. The expression of these MMPs was markedly increased in most GBMs with excellent correlation between mRNA and protein levels; activated forms of MMP-2 and MMP-9 were present in 8/18 and 7/18 of GBMs. A majority of GBMs (17/20) also expressed high levels of VEGF, as previously reported, with strong correlation between VEGF and MT1-MMP gene expression levels, and double immunostaining showed that VEGF and MT1-MMP peptides co-localize in tumour and endothelial cells. Our results suggest that the interplay between metalloproteinases and VEGF previously described in experimental tumours may also be operative in human GBMs. Because of its dual ability to activate MMP-2 and to up-regulate VEGF, MT1-MMP might be of central importance in the growth of GBMs and represent an interesting target for anti-cancer treatments. [less ▲]

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See detailInteraction Of Surfactin With Membranes: A Computational Approach
Deleu, Magali ULiege; Bouffioux, O.; Razafindralambo, Hary ULiege et al

in Langmuir (2003), 19(8),

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See detailAmélioration de la détection d’une maladie émergente : exemple de l’ encépahlopathie spongiforme bovine
Saegerman, Claude ULiege; Berkvens, D.; Speybroeck, N. et al

in Epidémiologie et Santé Animale (2003), 44

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See detailCell cycle duration at the time of maternal zygotic transition for in vitro produced bovine embryos: effect of oxygen tension and transcription inhibition.
Lequarré, Anne-Sophie ULiege; Marchandise, J.; Massip, A. et al

in Biology of Reproduction (2003), 69(5), 1707-13

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to ... [more ▼]

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to assess embryo quality. The goal of this study was to evaluate the duration of the fourth cell cycle, at the time of maternal-to-zygotic transition (MZT) in in vitro-produced bovine embryos by means of cinematographic analysis. We found that 75% of the embryos displayed a long fourth cycle (43.5 +/- 5.4 h) whereas the remaining embryos had a very short fourth cell cycle (8.9 +/- 2.9 h). Both groups did not differ in cleavage rhythm up to the eight-cell stage and timing of cavitation and blastocyst expansion was identical. However, embryos with a short fourth cell cycle had a better blastocyst rate than embryos with a long cycle (59% versus 38%, P < 0.01). Total cell number, inner cell mass (ICM):total cell ratio, and hatching rate were identical for blastocysts produced from embryos with either a long or a short fourth cell cycle. In a second experiment, we showed that increasing the oxygen tension, from 5% to 20%, decreased the percentage of embryos with a short fourth cell cycle, from 25% to 11% (P < 0.01), indicating that suboptimal culture conditions can influence the length of this cycle. Finally, we investigated whether fourth cell cycle duration could be influenced by transcription inhibition. With alpha-amanitin added at 18 h postinsemination (HPI), cleavage was reduced (66% versus 79%) and, at 70 HPI, the 9- to 16-cell rate increased (50% versus 25%) concomitantly with a 5- to 8-cell rate decrease (16% versus 47%). A similar pattern was observed when the drug was added at 6 HPI or 42 HPI but not at 0 HPI. Cinematographic analysis revealed that alpha-amanitin increased the first cell cycle duration whereas the second and third cell cycles were not affected. With the drug, one third of the embryos could develop up to the 9- to 16-cell stage and they all had a short fourth cell cycle (11.2 +/- 3.7 h) with a good synchrony of cleavage between blastomeres. These results suggest that duration of the fourth cell cycle of bovine embryo, during the MZT, is under a zygotic transcriptional control that can be affected by oxidative conditions. [less ▲]

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See detailModeling tracer injection and well-aquifer interactions: A new mathematical and numerical approach
Brouyère, Serge ULiege

in Water Resources Research (2003), 39(3),

[1] A new mathematical and numerical approach is presented to model solute exchange between a well and the surrounding aquifer for the interpretation of field tracer tests. On the basis of water and ... [more ▼]

[1] A new mathematical and numerical approach is presented to model solute exchange between a well and the surrounding aquifer for the interpretation of field tracer tests. On the basis of water and tracer mass balance equations integrated over the volume of water in the well, the approach allows for finite volumes of tracer fluid and water flush. It deals with tracer mixing and capturing in the well bore, local distortion of the flow field around the well, and possible tracer back-migration into the well. A numerical solution, implemented in the three-dimensional finite element groundwater flow and transport simulator SUFT3D, is proposed that allows for modeling nonuniform distributions of tracer mass fluxes along the well screens related to variations in aquifer hydraulic conductivity. Showing its ability to reproduce concentration evolutions monitored in a well during field tracer experiments, considering various injection conditions, validates the approach. [less ▲]

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See detailCharacterization of UDP-glucose : protein transglucosylase genes from potato.
Wald, F. A.; Kissen, R.; du Jardin, Patrick ULiege et al

in Plant Molecular Biology (2003), 52

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See detailEffect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
Mogensen, Carl Erik; Viberti, Giancarlo; Halimi, Serge et al

in Hypertension (2003), 41(5), 1063-71

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril ... [more ▼]

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP > or =140 mm Hg, <180 mm Hg, diastolic BP <110 mm Hg) were randomly assigned (age 59+/-9 years, 77% previously treated for hypertension). Results from 457 patients (intention-to-treat analysis) were available. After a 4-week placebo period, patients with albuminuria >20 and <500 microg/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg enalapril. The main outcome measures were overnight AER and supine BP. Both treatments reduced BP. Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3.0 [95% CI -5.6, -0.4], P=0.012; systolic BP -1.5 [95% CI -3.0, -0.1] diastolic BP P=0.019) and AER -42% (95% CI -50%, -33%) versus -27% (95% CI -37%, -16%) with enalapril. The greater AER reduction remained significant after adjustment for mean BP. Adverse events were similar in the 2 groups. Thus, first-line treatment with low-dose combination perindopril/indapamide induces a greater decrease in albuminuria than enalapril, partially independent of BP reduction. A BP-independent effect of the combination may increase renal protection. [less ▲]

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See detailCacophonie jurisprudentielle autour de la notion d’impôt
Rosoux, Géraldine ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

The article analyzes a decision of the Belgian judicial Supreme Court concerning the concept of "tax", and emphasizes the conflict between this decision and the case-law of the Belgian constitutional Court

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See detailInfluence Molecular Arrangement in Self-assembled Monolayers on Adhesion Forces Measured by Chemical Force Microscopy
Duwez, Anne-Sophie ULiege; Jonas, Ulrich; Klein, Hubert

in Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry (2003), 4

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See detailImproved rank-based dependence measures for categorical data
Vandenhende, François; Lambert, Philippe ULiege

in Statistics & Probability Letters (2003), 63

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for ... [more ▼]

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for dependence models using copulas. [less ▲]

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See detailFlow cytometric cerebrospinal fluid analysis in children
Häusler, M.; Sellhaus, B.; Schweizer, K. et al

in Pathology Research and Practice (2003), 199(10), 667-675

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume ... [more ▼]

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume, surface antigen expression) even in small amounts of cells. Data on CSF FC in children are very limited. Here, we summarize our 3-year experience of CSF FC routinely performed in pediatric patients with assumed inflammatory central nervous system (CNS) disease. Among 109 samples sent for analysis, flow cytometric detection of major leukocyte subsets was possible in 78% (85 out of 109), which exceeds the 31% rate of our retrospective microscopic pediatric control group. Apart from physiologic lymphocytes (100%) or monocytes (48%), 11 out of these 85 samples showed granulocytes, two showed proliferated monocytes, and nine displayed proliferated lymphocytes. In most children, the proliferated lymphocytes consisted of a polyclonal population of CD4+ and CD8+ T cells. Compared with literature data, eight children showed abnormally composed lymphocyte subsets (surface antigen expression) within the main lymphocyte population. However, none of these changes was specific for distinct diseases or allowed a distinction between patients with and without primary inflammatory processes. These data suggest that CSF FC may be the most effective modality to differentiate major CSF leukocyte subsets. At present, further differentiation of distinct cell populations, such as proliferated lymphocytes, is of limited clinical impact. This may, however, gain increasing interest in the future. [less ▲]

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See detailInduction of potato (Solanum tuberosum L.) tuber sprouting by hydrogen peroxide.
Bajji, M.; M'Hamdi, M.; Gastiny, F. et al

in Free Radical Research (2003), 37

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See detailLe complexe Chrysoperla carnea en Belgique (Neuroptera : Chrysopidae)
Bozsik, Andras; Mignon, Jacques ULiege; Gaspar, Charles

in Notes Fauniques de Gembloux (2003), 50

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à ... [more ▼]

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à l’aide d’un filet représente le principal mode d’échantillonnage. Les individus capturés furent identifiés sur base des descriptions de Thierry et al. (1992), Duelli (1995, 1999 communication personnelle), ainsi que par comparaison, soit avec différents types morphologiques (de D. Thierry), soit à des individus identifiés sur base de leurs chants (par P. Duelli). Chrysoperla kolthoffi sensu Cloupeau (Ch.c.c.4. ou « motorboat » sensu Henry) constitue le taxon le plus représenté dans les différentes localités. Chrysoperla carnea sensu Cloupeau (« low motorboat » sensu Henry) est également souvent rencontrée abondamment, principalement en automne. Seule Chrysoperla lucasina Lacroix est observée plus rarement chaque année et dans chaque lieu. La fréquence saisonnière de Ch. carnea s.C. est variable. Ainsi, elle est relativement faible en été et elle augmente progressivement au cours de l’automne. A cette période, les proportions de Ch. kolthoffi diminuent tandis que le taux de Ch. lucasina reste stable. [less ▲]

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See detailBiogeographical Observations On Four Scolytids (Coleoptera, Scolytidae) And One Lymexylonid (Coleoptera, Lymexylonidae) In Wallonia (Southern Belgium)
Henin, Jm.; Huart, O.; Rondeux, Jacques ULiege

in Belgian Journal of Zoology (2003), 133(2), 175-180

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999 ... [more ▼]

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999. Consequently, the ambrosia beetles Trypodendron domesticum L. and T. signatum (Fabricius) (Coleoptera, Scolytidae) initiated outbreaks and, in 2000 and 2001, they heavily contributed to the depreciation of nearly 1,600,000 m3 of stem volume (to upper limit girth of 22 cm) in the natural regions of “Ardenne” and “Belgian Lorraine”. Because of the lack of biogeographical data on both insects, of their conspicuous aggressiveness towards apparently healthy trees and of the economic importance of the beech wood chain in Belgium, a large-scale survey was undertaken in 2001, in order to outline the range of both ambrosia beetles in Wallonia. To this effect, a network of 172 traps baited with ethanol was set up, attempting to cover the Walloon beech forest as representatively as possible. Two other scolytids and one lymexylonid were also frequently caught, which made it possible to outline their regional distribution too. Although the damage was limited to the Ardenne and Belgian Lorraine, T. domesticum and T. signatum are widespread throughout Wallonia. We discuss these results, their long-term validity, the secondary pest status of these insects and the need for a permanent monitoring of the major forest pest species and diseases. [less ▲]

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See detailLa Belgique francophone face au référendum sarrois de 1955
Lanneau, Catherine ULiege

in Revue d'Allemagne et des Pays de Langue Allemande (2003), 35(4), 525-545

Since 1945, French-speaking Belgians were looking at the « Saar problem », stumbling block of Europe’s build-up, with a mixture of awe and hope. In 1955, as the inhabitants were asked to vote on a ... [more ▼]

Since 1945, French-speaking Belgians were looking at the « Saar problem », stumbling block of Europe’s build-up, with a mixture of awe and hope. In 1955, as the inhabitants were asked to vote on a peculiar status of “Europeanised” autonomous territory (within the WEU but keeping economical union with France), the coming plebiscite was seen as a good bid on Europe’s future. At first, Belgian public opinion was under the influence of optimistic statements made by official French and autonomist propaganda. After the failure of the plebiscite, Belgian journalists and diplomats tried to find some simple and often rather bombastic explanations: intern and extern weakness of France seen as over-cautious or tinted with europhobia, lack of appeal of the European idea, attractiveness of the German economical bloom, Nazi nostalgia or even perennial nationalism of the German man. Then, Saarland, having refused to be an oddity in a nation-based Europe, fell from public interest into oblivion... [less ▲]

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See detailLes lymphomes
Jerusalem, Guy ULiege; Hustinx, Roland ULiege; Beguin, Yves ULiege et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2003), 27(8), 401-410

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique ... [more ▼]

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique concernant le diagnostic, la classification de la maladie et la détermination des facteurs pronostiques permet de choisir la thérapeutique la plus appropriée. Les auteurs passent en revue les examens à réaliser au diagnostic et discutent de la place de la tomographie à émission de positons (TEP) dans cette indication. Ils évoquent ensuite le problème des masses résiduelles. La TEP est maintenant l'examen de choix pour établir le bilan de fin de traitement. Les auteurs discutent également du rôle potentiel de la TEP pour l'évaluation thérapeutique précoce et le suivi régulier des patients après traitement pour lymphome. Enfin, l'aspect particulier des lymphomes de l'enfant est abordé. [less ▲]

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See detailLa libre circulation des personnes dans l’Union européenne. Chronique de jurisprudence et de législation
Carlier, Jean-Yves ULiege

in Journal de Droit Européen [=JDE] (2003), 11(107), 79

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See detailPara-Adrenal Adrenal Pseudocyst
Milicevic, Mladen ULiege; Dondelinger, Robert ULiege; Detry, Olivier ULiege

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2003), 86(3, May-Jun), 166-7

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See detailA la recherche d'une langue perdue
Boutier, Marie-Guy ULiege

in Bulletin de la Commission Royale de Toponymie et de Dialectologie = Handelingen van de Koninklijke Commissie voor Toponymie en Dialectologie (2003), 75

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See detailL'urticaire et ses implications systémiques
Dezfoulian, Bita ULiege; Khalil, Z.; de LA BRASSINNE, Michel ULiege

in Revue Médicale de Liège (2003), 58(12), 751-756

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several ... [more ▼]

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several etiological, pathophysiological and therapeutic problems. We will develop the acute and chronic urticaria as well as their different associations with systemic diseases. Some current data concerning chronic idiopathic autoimmune urticaria is reviewed. The management and therapeutics will be discussed. [less ▲]

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See detailCognitive impairment, dementia and quality of life.
Kurz, Xavier; Scuvée-Moreau, Jacqueline ULiege; Vernooij-Dassen, M. et al

in Acta Neurologica Belgica (2003), 103

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See detailUrticaire de contact suite à l’application d’un fond de teint contenant de l’huile de sésame
Dezfoulian, Bita ULiege; de LA BRASSINNE, Michel ULiege

in Revue Française d'Allergologie et d'Immunologie Clinique (2003), 43

A number of cosmetic products containing sesame oil are used for daily cutaneous care. The risk of secondary induction of eczema or even anaphylactic shock after topical use of products containing ... [more ▼]

A number of cosmetic products containing sesame oil are used for daily cutaneous care. The risk of secondary induction of eczema or even anaphylactic shock after topical use of products containing vegetable oils is still unknown. We describe the case of 36-years-old atopic, sesame sensitized women who presented with contact urticaria after application of a foundation cream containing sesame oil. Immediate prick and patch tests with sesame oil, sesame grains, the foundation cream and its components confirmed this sensitization. We discuss the innocuousness of vegetable and animal products present in foods and in cosmetics and problems that may occur when they are used by patients during an inflammatory phase of atopic dermatitis and by patients with specific sensitization to these allergens. [less ▲]

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See detailPiracetam Inhibits The Lipid-Destabilising Effect Of The Amyloid Peptide A Beta C-Terminal Fragment
Mingeot-Leclercq, Mp.; Lins, Laurence ULiege; Bensliman, M. et al

in Biochimica et Biophysica Acta-Biomembranes (2003), 1609(1), 28-38

Amyloid peptide (Abeta) is a 40/42-residue proteolytic fragment of a precursor protein (APP), implicated in the pathogenesis of Alzheimer's disease. The hypothesis that interactions between Abeta ... [more ▼]

Amyloid peptide (Abeta) is a 40/42-residue proteolytic fragment of a precursor protein (APP), implicated in the pathogenesis of Alzheimer's disease. The hypothesis that interactions between Abeta aggregates and neuronal membranes play an important role in toxicity has gained some acceptance. Previously, we showed that the C-terminal domain (e.g. amino acids 29-42) of Abeta induces membrane permeabilisation and fusion, an effect which is related to the appearance of non-bilayer structures. Conformational studies showed that this peptide has properties similar to those of the fusion peptide of viral proteins i.e. a tilted penetration into membranes. Since piracetam interacts with lipids and has beneficial effects on several symptoms of Alzheimer's disease, we investigated in model membranes the ability of piracetam to hinder the destabilising effect of the Abeta 29-42 peptide. Using fluorescence studies and 31P and 2H NMR spectroscopy, we have shown that piracetam was able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. While the peptide induced lipid disorganisation and subsequent negative curvature at the membrane-water interface, the conformational analysis showed that piracetam, when preincubated with lipids, coats the phospholipid headgroups. Calculations suggest that this prevents appearance of the peptide-induced curvature. In addition, insertion of molecules with an inverted cone shape, like piracetam, into the outer membrane leaflet should make the formation of such structures energetically less favourable and therefore decrease the likelihood of membrane fusion. [less ▲]

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See detailModulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.
Liégeois, Jean-François ULiege; Mercier, Frédéric ULiege; Graulich, Amaury et al

in Current Medicinal Chemistry (2003), 10(8), 625-47

Small conductance calcium-activated potassium (SK) channels are found in many types of neurons as well as in some other cell types. These channels are selective for K(+) and open when intracellular Ca(2 ... [more ▼]

Small conductance calcium-activated potassium (SK) channels are found in many types of neurons as well as in some other cell types. These channels are selective for K(+) and open when intracellular Ca(2+) rises to omega 500 nM. In neurons, this occurs during and after an action potential. Activation of SK channels hyperpolarizes the membrane, thus reducing cell excitability for several tens or hundreds of milliseconds. This phenomenon is called a afterhyperpolarization (AHP). Three subtypes of SK channels (SK1, SK2, SK3) have been cloned and exhibit a differential localization in the brain. SK channels may play a role in physiological and pathological conditions. They may be involved in the control of memory and cognition. Moreover, they are heavily expressed in the basal ganglia (in particular in the substantia nigra, pars compacta) and in the limbic system, suggesting that they may modulate motricity and emotional behaviour. Based on these facts, SK channel subtypes may be a suitable target for developing novel therapeutic agents, but more work is needed to validate these targets. Hence, there is a great need for selective ligands. Moreover, although the risk of peripheral side-effects for SK channel modulators appears to be low, some questions remain to be investigated. Currently, different molecules are known as SK channel modulators. Apamin is a very potent peptidic agent; it produces a strong blockade of these targets which is only very slowly reversible and it has limited selectivity. Dequalinium was found to be an effective blocker. Different chemical modulations on the dequalinium structure led to the discovery of highly potent bis-quinolinium derivatives such as UCL 1684. Other bis-(2-amino-benzimidazole) derivatives are in development. On the other hand, quaternary salts of bicuculline were reported to be effective in inhibiting AHPs. More recent developments on structurally-related molecules revealed that methyl-laudanosine is a new interesting tool for exploring SK channel pharmacology. Finally, a family of compounds has been shown to facilitate SK channel opening. Such compounds may be useful in treating disorders involving neuronal hyperexcitability. [less ▲]

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See detailFaillite de l'imaginaire, la dermatite atopique ?
Dracoulis, H.; Gauthier, Jean-Marie ULiege

in Revue Française de Psychiatrie et de Psychologie Médicale (2003), 7(66), 51-56

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See detailEtudes des impacts hydrauliques, sédimentologiques et écologiques liés aux travaux hydrauliques sur la Semois
Gob, Frédéric; Houbrechts, Geoffrey ULiege; Mols, Julien et al

in Belgeo (2003), 3

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux ... [more ▼]

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux, géomorphologiques et sédimentologiques. [less ▲]

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See detailEffect of somatic growth, strain and sex on double-chamber plethymosgraphic respiratory function values in healthy mice
Flandre, Th.; Leroy, Pascal ULiege; Desmecht, Daniel ULiege

in Journal of Applied Physiology (2003), 94(3), 1129-1136

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See detailLa résolution de problèmes : un processus complexe de 'modélisation mathématique'
Fagnant, Annick ULiege; Demonty, Isabelle ULiege; Lejong, Michèle ULiege

in Informations pédagogiques (2003), 54

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See detailImpact of medical specialist' locus of control on communication skills in oncological interviews
Libert, Y.; Janne, P.; Razavi, D. et al

in British Journal of Cancer (2003), 88

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See detailFin de législature: le point sur l'autonomie fiscale des communautés et des régions
Bourgeois, Marc ULiege

in Comptabilité et Fiscalité Pratiques (2003)

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See detailLoss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice
Robaye, B.; Ghanem, E.; Wilkin, F. et al

in Molecular Pharmacology (2003), 63(4), 777-783

The P2Y4 receptor is responsive to UTP in human and to ATP and UTP in rodents. With the aim of identifying its pharmacotherapeutic interest, we generated P2Y4-null mice by a classic gene targeting method ... [more ▼]

The P2Y4 receptor is responsive to UTP in human and to ATP and UTP in rodents. With the aim of identifying its pharmacotherapeutic interest, we generated P2Y4-null mice by a classic gene targeting method. The proportion of genotypes was consistent with X-linked Mendelian transmission. Gene inactivation was checked by the complete disappearance of P2Y4 receptor mRNA from liver, stomach, and intestine. The P2Y4-null mice had a grossly normal behavior, growth, and reproduction. Chloride secretion by the jejunal epithelium was assessed in Ussing chambers by the measurement of the short circuit current in the presence of phlorizin. We show here that the UTP- and ATPinduced chloride secretory responses observed in wild-type mice are abolished in P2Y4-null mice. This is the first clearcut demonstration of a biological role of the P2Y4 receptor [less ▲]

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See detailTopical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo.
Humbert, Philippe G; Haftek, Marek; Creidi, Pierre et al

in Experimental Dermatology (2003), 12(3), 237-44

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this ... [more ▼]

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this molecule as a potential candidate for use in the prevention and treatment of skin ageing. A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment. A double-blind, randomized trial was performed over a 6-month period, comparing the action of the vitamin C cream vs. excipient on photoaged skin. Clinical assessments included evaluation at the beginning and after 3 and 6 months of daily treatment. They were performed by the investigator and compared with the volunteer self assessment. Skin relief parameters were determined on silicone rubber replicas performed at the same time-points. Cutaneous biopsies were obtained at the end of the trial and investigated using immunohistochemistry and electron microscopy. Clinical examination by a dermatologist as well as self-assessment by the volunteers disclosed a significant improvement, in terms of the 'global score', on the vitamin C-treated side compared with the control. A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and well-tolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing. [less ▲]

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See detailEtude rétrospective de quarante et un cas d’insuffisance mitrale chez le cheval (1995-2001).
Maurin, Emmanuel; Amory, Hélène ULiege; Sandersen, Charlotte ULiege

in Pratique Vétérinaire Equine (2003), 35

Une étude rétrospective portant sur quarante et un chevaux qui présentent une insuffisance cardiaque mitrale a été réalisée afin de mieux décrire cette affection et de préciser les répercussions médicales ... [more ▼]

Une étude rétrospective portant sur quarante et un chevaux qui présentent une insuffisance cardiaque mitrale a été réalisée afin de mieux décrire cette affection et de préciser les répercussions médicales et sportives liées à cette maladie. L'insuffisance mitrale est diagnostiquée grâce à des examens cliniques et échographiques, puis un questionnaire (évolution clinique et sportive) est adressé aux propriétaires des animaux. L’analyse de ces dossiers permet en particulier d’évaluer, d'une part, l’existence d’une association entre les signes d’insuffisance cardiaque congestive et certaines lésions cardio-vasculaires (lésions valvulaires, dilatation de l’atrium gauche, etc.) ou d'autres symptômes (fibrillation auriculaire, etc.), d'autre part, d’apprécier la corrélation éventuelle entre ces différents symptômes ou lésions et la survie des chevaux affectés. Les résultats ainsi que les biais possibles de cette étude sont ensuite discutés. [less ▲]

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See detailLa figure de la Vierge Marie dans l’histoire des femmes et du féminisme
Delfosse, Annick ULiege

in Hieros : Bulletin Annuel de la Société Belgo-luxembourgeoise d'Histoire des Religions (2003), 8

The A. offers to study the place of the Marian figure in the women story. She proves to show various points of view: the masculine cleric authorities’ use of the Virgin as an identification norm imposed ... [more ▼]

The A. offers to study the place of the Marian figure in the women story. She proves to show various points of view: the masculine cleric authorities’ use of the Virgin as an identification norm imposed to the women as well as the claim of these latter to define the Virgin also as an emancipation tool. [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULiege; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

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See detailInterlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty.
Dehouck, P.; Vander Heyden, Y.; Smeyers-Verbeke, J. et al

in Journal of Chromatography. A (2003), 1010(1), 63-74

Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been ... [more ▼]

Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in one laboratory, the method was now validated in an interlaboratory study. Validation studies are commonly used to test the fitness of the analytical method prior to its use for routine quality testing. The data derived in the interlaboratory study can be used to make an uncertainty statement as well. The relationship between validation and uncertainty statement is not clear for many analysts and there is a need to show how the existing data, derived during validation, can be used in practice. Eight laboratories participated in this interlaboratory study. The set-up allowed the determination of the repeatability variance, s(2)r and the between-laboratory variance, s(2)L. Combination of s(2)r and s(2)L results in the reproducibility variance s(2)R. It has been shown how these data can be used in future by a single laboratory that wants to make an uncertainty statement concerning the same analysis. [less ▲]

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See detailLe cas clinique du mois. La maladie de still de l'adulte: une cause rare d'hepatite aigue febrile
Michels, V.; Delwaide, Jean ULiege; Vermeulen, P. et al

in Revue Médicale de Liège (2003), 58(12), 729-733

A 63-year-old woman was hospitalized for the third time in one year for asthenia, fever and chills, jaundice, cytolysis and cholestasis. An adult onset Still's disease was diagnosed. Hepatic ... [more ▼]

A 63-year-old woman was hospitalized for the third time in one year for asthenia, fever and chills, jaundice, cytolysis and cholestasis. An adult onset Still's disease was diagnosed. Hepatic manifestations, diagnostic criteria and efficient therapy of AOSD will be reviewed. [less ▲]

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; De Nève, Nancy et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULiege; Balsat, Alain; Dujardin, Marco et al

Scientific journal (2003)

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See detailAdaptive mesh generation for mould filling problems in resin transfer moulding
Béchet, Eric ULiege; Ruiz, E.; Trochu, François et al

in Composites : Part A, Applied Science & Manufacturing (2003), 34(9), 813-834

In injection moulding processes such as Resin Transfer Moulding (RTM) for example, numerical simulations are usually performed on a fixed mesh, on which the numerical algorithm predict the displacement of ... [more ▼]

In injection moulding processes such as Resin Transfer Moulding (RTM) for example, numerical simulations are usually performed on a fixed mesh, on which the numerical algorithm predict the displacement of the flow front. Error estimations can be used in the numerical algorithm to optimise the mesh for the finite element analysis. The mesh can be also adapted during mould filling to follow the shape of the moving boundary. However, in order to minimize computer time, it is preferable to optimise the mesh before carrying out the filling calculation. In this paper, these ideas are adapted to 3D shells, which represent the most common type of composite parts manufactured by RTM. An error estimator generally used in planar or solid geometries is extended for curved 3D surfaces in the specific case of RTM calculations. The extension consists of a projection of the solution field in the tangent plane to avoid problems related to the curvature of the part. Some other issues specific to shell geometries are pointed out and the results of a filling simulation made on a real part are presented. Non-isothermal filling simulations are also carried out in a rectangular mould to illustrate the stability conditions that arise from the convective heat transfer problem. Finally, an analytical study of radial injections is carried out to illustrate issues related to four types of different mesh refinement procedures: (1) a constant time step, (2) constant radial density (to allow a regular progression of the flow front at each time step), (3) a constant Courant number (to ensure stable thermal simulations); and (4) finally, a constant interpolation error. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailAcetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
Ambrosini, A.; Pierelli, F.; Schoenen, Jean ULiege

in Cephalalgia : An International Journal of Headache (2003), 23(2), 75-8

Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2 ... [more ▼]

Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2+-channels on motor axons controlling stimulation-induced acetylcholine release. Acetazolamide, which is thought to ameliorate ion channel function, was shown effective in familial hemiplegic migraine and episodic ataxia type 2, both of which are associated with mutations of the neuronal Ca2+-channel gene CACNA1A, as well as in aura status. We treated therefore in an open pilot study five non-hemiplegic migraineurs showing mild SFEMG abnormalities with acetazolamide for several weeks. This was followed by a normalization of SFEMG recordings in all patients and by clinical improvement in four. These results support the assumption that the subclinical impairment of neuromuscular transmission found in certain migraineurs might be due to dysfunctioning Ca2+-channels. [less ▲]

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See detailDevelopment Of Real-Time Pcr For The Rapid Detection Of Episomal Banana Streak Virus (Bsv)
Delanoy, Martine; Salmon, Marc ULiege; Kummert, Jean et al

in Plant Disease (2003), 87(1), 33-38

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See detailIndo-iranien *aruna
Swennen, Philippe ULiege

in Journal Asiatique (2003), 291

In sanskrit, aruna- means "red, pink". In Avestan, occidental scholars translate auruna by "wild". Nothing explains this paradox between two words whose etymological equivalence is obvious. A precise ... [more ▼]

In sanskrit, aruna- means "red, pink". In Avestan, occidental scholars translate auruna by "wild". Nothing explains this paradox between two words whose etymological equivalence is obvious. A precise reading of the Rig-Vedic stanzas shows that the feminine form of this adjective always qualifies the Dawn. This systematic use modified the meaning of the adjective. Beyond its chromatic value, it indicates in the Rigvedic poetries the intermediate time linking day and night. [less ▲]

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See detailLiège-Paris 1848 : Littérature, féminisme et Révolution
Droixhe, Daniel ULiege

in Bulletin de l'Académie Royale de Langue et de Littérature Françaises (2003), LXXXI(1-2), 41-49

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See detailSpeed of Sound Measurements of the Third Metacarpal Bone in Young Exercising Thoroughbred Racehorses
Carstanjen, B.; Lepage, O. M.; Hars, O. et al

in BONE (2003), 33

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See detailLa Zone Villageoise de Chasse de Sia (Ranch de Gibier de Nazinga, Burkina Faso)
Vermeulen, Cédric ULiege; Ouédraogo, M.

in Parcs & Réserves (2003), 58(2), 32-44

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See detailDetuning effects in the one-photon mazer
Bastin, Thierry ULiege; Martin, John ULiege

in Physical Review. A (2003), 67

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far ... [more ▼]

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far from being direct. Interesting effects of the mazer physics are pointed out. In particular, it is shown that the cavity may slow down or speed up the atoms according to the sign of the detuning and that the induced emission process may be completely blocked by use of a positive detuning. It is also shown that the detuning adds a potential step effect not present at resonance and that the use of positive detunings defines a well-controlled cooling mechanism. In the special case of a mesa cavity mode function, generalized expressions for the reflection and transmission coefficients have been obtained. The general properties of the induced emission probability are finally discussed in the hot, intermediate, and cold atom regimes. Comparison with the resonant case is given. [less ▲]

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See detailLes onychomycoses--echec et mat?
Arrese Estrada, Jorge ULiege; Quatresooz, Pascale ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2003), 58(9), 559-62

According to individuals, onychomycoses or their treatments can be held in check. Some of the "promises" sometimes offered by pharmaceutical companies are not fully kept and hopes of cure may remain wild ... [more ▼]

According to individuals, onychomycoses or their treatments can be held in check. Some of the "promises" sometimes offered by pharmaceutical companies are not fully kept and hopes of cure may remain wild. Some special therapeutic strategies should be employed in case of recalcitrant or recurrent onychomycosis. [less ▲]

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See detailLarge phosphorus hyperfine coupling as a sensitive tool for studying molecular dynamics : ESR and Molecular Mechanics studies of ring interconversion in cis-2,5-diphosphoryl-2,5-dimethyl-pyrrolidinoxyl radical
Rockenbauer, Antal; Gaudel-Siri, Anouk; Siri, Didier et al

in Journal of Physical Chemistry A (2003), 107(19), 3851-3857

ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was ... [more ▼]

ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was observed for t-1; however, for c-1, the inner lines of the 1:2:1 triplet showed a dramatic broadening characteristic of chemical exchange between two equivalent conformations. Owing to the large difference in the hyperfine splitting constants (hfsc) of the exchanging phosphorus (¢aP 21 G), the coalescence temperature was unusually high (193 K, in n-pentane), and the potential barrier for ring interconversion (10.5 kJ mol-1) was easily obtained from the temperature dependence of the exchange rate. This value was in very good agreement with the value obtained for an empirical pseudorotational potential (11 kJ mol-1) that was adjusted to fit the temperature dependence of the phosphorus hfsc. For c-1, molecular mechanics calculations gave similar characteristics for the pseudorotational potential and indicated the existence of two identical minima with distorted geometries lying between 3T4 and 3E or 4T3 and E3. For t-1, only the 3T4 conformer was found to be significantly populated. Frozen solution spectra showed that the phosphorus hfsc anisotropy is higher when the C-P bond is pseudoaxial; this result can be explained by a geometry-dependent delocalization of the unpaired electron into the phosphorus 3p orbitals. [less ▲]

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See detailOptimisation de la transformation génétique de la pomme de terre par Agrobacterium tumefaciens. Utilisation de la résistance à l'hygromycine comme marqueur sélectif.
M'Hamdi, M.; Rouvière, C.; Rojas-Beltran J et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7

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See detailThe extraforaminal juxtafacet cyst as a rare cause of L5 radiculopathy: a case report.
Salmon, Bernard L; Deprez, Manuel ULiege; Stevenaert, Achille ULiege et al

in Spine (2003), 28(19), 405-7

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal ... [more ▼]

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal juxtafacet cysts develop most frequently at the dorsal aspect of the zygapophysial joint, sometimes in the posterolateral area of the canal. In one case, they have been described in the foraminal and extraforaminal region. METHODS: Description of the case report. RESULT: The authors report one case of a strictly extraforaminal juxtafacet cyst responsible for L5 sciatica. CONCLUSIONS: Juxtafacet cysts of the spine represent an infrequent cause of sciatica, usually when they grow in the canal, or more exceptionally when they occupy the foraminal or extraforaminal areas. [less ▲]

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Yeast (2003), 20(S291),

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See detailLe développement de la filière "Poulet d'Ardenne" en Région Wallonne
Leroy, Pascal ULiege

in Troupeaux et cultures des tropiques (2003), 2

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See detailThe fate of the adjacent motion segments after lumbar fusion.
Gillet, Philippe ULiege

in Journal of Spinal Disorders & Techniques (2003), 16(4), 338-45

Lumbar spine fusion is a commonly performed procedure in various pathologic conditions of the spine. Its role remains debated, and moreover, delayed complications may occur, among which is transitional ... [more ▼]

Lumbar spine fusion is a commonly performed procedure in various pathologic conditions of the spine. Its role remains debated, and moreover, delayed complications may occur, among which is transitional segment alteration leading to recurrence of back pain, gross instability, and neurologic symptoms. Little is known about the long-term prevalence of this complication because of a lack of specific studies. We analyzed the fate of the transitional segments in a homogeneous group of patients operated on during a 14-year period for degenerative conditions of the lumbar spine resistant to conservative treatment. Follow-up ranged from 2 to 15 years. Seventy-five percent of our study group had a minimal 5-year follow-up. In this subgroup, 41% of the patients developed transitional segment alterations, and 20% needed a secondary operation for extension of the fusion. Potential risk factors such as postoperative delay, length of fusion, and spine imbalance were recognized. The frequency of delayed alterations of the adjacent segment and the severity of symptoms related to this complication in this study raise questions about the justification of fusion procedures in degenerative conditions of the spine without threatening instability. Data from the literature confirm the severity of the problem, but many uncertainties remain because of the lack of homogeneous and complete data on both the normal evolution of motion segments of the lumbar spine with age and the fate of the same segments when transformed in transitional segments. Future prospective studies on the subject are needed and must deal with homogeneous groups of patients. More reconstructive surgical procedures need to be developed to lessen the need for fusion procedures. [less ▲]

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See detailNombres et jeux enfantins
Lempereur, Françoise ULiege

in Enquêtes du Musée de la Vie Wallonne (2003), XX

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ... [more ▼]

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ethnomusicologist Constantin Brailoiu [less ▲]

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See detailMéthodologie des plans de gestion piscicole en Région wallonne, application au bassin de la Semois
Conjaerts, C.; Hauptmann, Y.; Waltzing, D. et al

in Pêcheur Belge (Le) (2003), (8), 22-25

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See detailMycobacterium bovis meningitis in a cow with clinical signs of BSE.
Roels, S.; Walravens, K.; Saegerman, Claude ULiege et al

in Veterinary Record : Journal of the British Veterinary Association (2003), 152(26), 807-8

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See detailLeçons de l’éphémère. La Cour d’arbitrage et le "Renouveau’ électoral" – La Cour d’arbitrage et la suspension
Rosoux, Géraldine ULiege

in Revue Belge de Droit Constitutionnel (2003)

The articles analyzes the electoral reform of 2003 and points out the competence of the Belgian constitutional Court to suspend legislative norms.

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See detailDe Cheddar- en Creswell-spitsen van Zeijen (Dr.): ‘projectielen’ of ‘messen’?
Rots, Veerle ULiege; Stapert, Dick; Johanssen, Lykke

in Paleo-Aktueel (2003), 13

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See detailPhysical and textural characteristics of hydrogenated low-erucic acid rapeseed oil and low-erucic acid rapeseed oil blends
Danthine, Sabine ULiege; Deroanne, Claude ULiege

in Journal of the American Oil Chemists' Society (2003), 80(2), 109-114

Low-erucic acid rapeseed oil (LERO) and hydrogenated low-erucic acid rapeseed oil (HLERO) were blended in binary systems. The blends were then studied for their physical properties such as solid fat ... [more ▼]

Low-erucic acid rapeseed oil (LERO) and hydrogenated low-erucic acid rapeseed oil (HLERO) were blended in binary systems. The blends were then studied for their physical properties such as solid fat content, melting curves by DSC, textural properties, and polymorphism. Phase behavior diagrams were constructed from the DSC and X-ray results, and isosolid diagrams were constructed from the NMR results. The mixture of HLERO and LERO displayed a monotectic behavior for all the storage time at 15degreesC. The aim of this work was to evaluate physical characteristics of binary blends of HLERO and nonhydrogenated LERO in order to use only LERO and hardened LERO in bakery shortenings. The mixture of 60% HLERO and 40% LERO is suitable to use as a plastic shortening, This blend is beta tending upon storage at 15degreesC. It could be used in pie crust applications. [less ▲]

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See detailEstimation of habitat quality based on plant community, and effects of isolation in a network of butterfly habitat patches
Sawchik, J.; Dufrêne, Marc ULiege; Lebrun, Philippe

in Acta Oecologica (2003), 24(1), 25-33

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ... [more ▼]

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ecological network for five butterfly species (Brenthis ino, Clossiana selene, Lycaena helle, Lycaena hippothoe, Proclossiana eunomia) inhabiting wet meadows. Abundance predictions were performed on the basis of botanical relevés with a multiple-species approach combining canonical correspondence analysis and multiple regression. Models are defined on a reference site set and are evaluated on a test site set. All the fitted models predicted the abundance of the butterfly species considerably well (from 61 to 86% of the variation). We evaluated the potential consequences of isolation on local populations, by comparing predicted and observed abundance. It was expected that greater differences would be observed when sites were more isolated. On the test set, differences between predicted and observed abundance were largely correlated to site isolation for L. helle and P. eunomia. The most isolated sites had greater chances to be empty, even if they had high-quality habitat. Reciprocally, when the sites were less isolated, the abundance observed was always greater than predicted, seeming to confirm the role of rescue effects. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. [less ▲]

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See detailPerfluorocarbons and Haemoglobin Solutions: Will They Ever Reach Clinical Practice?
Lamy, Maurice ULiege; Deby-Dupont, G.

in Acta Anaesthesiologica Belgica (2003), 54(4), 299-300

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See detailA New Wor(l)d Order: Language in the Fiction of the New Caribbean Diaspora
Ledent, Bénédicte ULiege

in Revista Alicantina de Estudios Ingleses (2003), 16

Language has always been a major issue for post-colonial writers, being at once an instrument used by the colonial power and one of the prime avenues of resistance to this oppression. For displaced West ... [more ▼]

Language has always been a major issue for post-colonial writers, being at once an instrument used by the colonial power and one of the prime avenues of resistance to this oppression. For displaced West Indian writers in particular, English has been a significant tool for self-assertion, all the more ambiguous because it is their "mother tongue" while being the tongue of their ancestors' masters as well. This paper analyses how the younger novelists of the Caribbean diaspora use and transform the English language in their search for a new diasporic, cross-cultural identity. Robert Antoni, Michelle Cliff, Fred D'Aguiar, David Dabydeen, M. Nourbese Philip and Caryl Phillips will be among the writers mentioned in this paper. While some of them resort to non-standard linguistic forms and thereby deal head on with the tension between local languages and the need for international communication, others have had a more oblique approach to linguistic change, one that involves not so much lexis as tone and rhythm and often operates by rehabilitating silenced voices from the past. I will attempt to demonstrate how these writers have turned speech into a site of creolization expressive of what Caryl Phillips has called" A New World Order". [less ▲]

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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULiege; Henry, Frédérique ULiege; Paquet, Philippe ULiege et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailEstrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseases
Rakic, Jean-Marie ULiege; Lambert, Vincent ULiege; Deprez, Manuel ULiege et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]

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See detailCase 61: ileocecal sarcoidosis.
NCHIMI LONGANG, Alain ULiege; Francotte, Nadine; Rausin, Leon et al

in Radiology (2003), 228(2), 452-5

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See detailA review of the major causes of digestive disorders in the European rabbit
Marlier, Didier ULiege; Dewrée, Roxane; Delleur, Valéry et al

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 385-392

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state ... [more ▼]

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state of knowledge on two diseases of unknown origin, the so called Rabbit Epizootic Enteropathy and Mucoid Enteropathy is also presented. [less ▲]

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