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See detailSeasonal temperature and salinity fields in the Mediterranean Sea: Climatological analyses of a historical data set
Brasseur, P.; Beckers, Jean-Marie ULg; Brankart, J. M. et al

in Deep-Sea Research Part I, Oceanographic Research Papers (1996), 43(2), 159-192

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly ... [more ▼]

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly distributions of hydrographic properties have been computed by a variational inverse method as an alternate to the standard Gandin (1969; Objective analysis of meterological fields, Israeli Program for Scientific Translation, Jerusalem) procedure. The spline solutions of the minimization problem are demonstrated to be numerically and theoretically equivalent to field estimates obtained by conventional objective analysis. The application of a finite-element technique allows analysis to be performed in the model space rather than in the observational space, which substantially improves the numerical efficiency of the procedure. The parameters of the scheme are adjusted according to the statistics of the climatological data. The results,realized as gridded data sets (horizontal resolution of 0.25 degrees), show some trends in seasonal variability affecting the properties of water masses. As expected, the upper layer is subject to a well-defined seasonal signal affecting both the temperature and salinity fields. Error maps, reflecting the degree of uncertainty in the analyses, have been systematically produced. The present work is conceived as a basic support to more advanced studies such as diagnostic calculations, initialization of dynamical models, assimilation of hydrological data into primitive equation models, or planning of experimental surveys. New versions of the climatological fields will be released as data are added to the historical data base. Copyright (C) 1996 Elsevier Science Ltd. [less ▲]

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See detailHumanitarian aid and health services in Eastern Kivu, Zaïre: collaboration or competition
Goyens, Philippe; Porignon, Denis ULg; Mugisho Soron'Gane, Etienne et al

in Journal of Refugee Studies (1996), 9(3), 268-280

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean ... [more ▼]

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean health services in the health districts of Rutshuru, Kirotshe and Masisi, in spite of the political and socioeconomic disintegration of the country, were still functioning, and the local hospitals and health centres, although overwhelmed, contributed to a large extent to the disaster response. Prominent among the major problems facing the local health services were their limited adaptability, the inadequate coordination and collaboration offered to them by the humanitarian aid agencies, and the discrimination between the direct and secondary victims of the emergency. The public health consequences of the Rwandan refugee crisis for the Zairean population constitute an integral part of the disaster. [less ▲]

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See detailAcrylonitrile on Cu(100): a density functional theoretical study of adsorption and electrochemical grafting
Geskin, V. M.; Lazzaroni, Roberto; Mertens, Marc et al

in Journal of Chemical Physics (1996), 105(8), 3278-3289

We present a density functional theoretical study of neutral and negatively charged complexes of acrylonitrile (AN) with several clusters representing the Cu(100) surface. An external electric field is ... [more ▼]

We present a density functional theoretical study of neutral and negatively charged complexes of acrylonitrile (AN) with several clusters representing the Cu(100) surface. An external electric field is used to induce electron transfer onto the adsorbed molecule, in order to model the initial stage of electrochemical polymerization of AN on a copper electrode. We compare different possibilities of AN interaction with the metal and determine the most favorable configurations of the adsorbates in the absence and in the presence of the electric field. We discuss the influence of the electrochemical polarization on the type of AN adsorption, in relation with the experimental data on the adsorption of AN and electrochemical grafting of polyacrylonitrile. [less ▲]

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See detailAtomic data from the IRON Project. XIX. Radiative transition probabilities for forbidden lines in Fe II
Quinet, Pascal ULg; Le Dourneuf, M; Zeippen, C J

in Astronomy and Astrophysics. Supplement Series (1996), 120

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See detailPlace de la nalbuphine (Nubain) dans l'arsenal analgésique moderne
SENARD, Marc ULg; Tazarourte, K.; Darmon, P. L.

in Urgences médicales (1996), 15

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See detailTreatment of osteoporosis
Reginster, Jean-Yves ULg

in Medycina Po Dyplomie (1996)

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See detailUne cause parfois meconnue de lesions vasculaires: la maladie de Behcet.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1996), 51(10), 639-46

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See detailInteractions between acetylcholine and substance P effects on lung mechanics in the rabbit.
Delaunois, Annie ULg; Gustin, Pascal ULg; Segura, P. et al

in Fundamental & Clinical Pharmacology (1996), 10(3), 278-88

The pharmacological mechanisms involved in the acetylcholine (ACh)- and substance P (SP)-induced changes in pulmonary mechanics were studied in isolated perfused rabbit lungs. Tracheal pressure (Ptr) and ... [more ▼]

The pharmacological mechanisms involved in the acetylcholine (ACh)- and substance P (SP)-induced changes in pulmonary mechanics were studied in isolated perfused rabbit lungs. Tracheal pressure (Ptr) and airflow were measured by a Fleisch pneumotachograph and pressure transducers. Air volume, lung resistance (RL) and dynamic compliance (Cdyn) were calculated. ACh induced a dose-dependent increase in Ptr and RL, and a decrease in Cdyn. These effects were strongly prevented by atropine, and partly by SR140333, a neurokinin NK1 receptor antagonist; SR48968, a neurokinin NK2 receptor antagonist; indomethacin and antihistaminics. Ketanserin had no significant protective effect against ACh. SP also induced concentration-dependent increases in RL and decreases in Cdyn. SR140333 and atropine strongly inhibited the effects of SP, while ketanserin, SR48968, antihistaminics and indomethacin did not protect the lungs against this drug. 5-hydroxytryptamine induced no significant change in lung mechanic parameters. Cumulative concentrations of histamine increased RL and decreased Cdyn. We conclude that ACh-induced changes in lung resistance and compliance are in part mediated by a direct effect on airway smooth muscle and in part by the stimulation of C fibers, by the release of histamine from mast cells and by the synthesis of arachidonic acid metabolites. In turn, the effects of SP on lung mechanics are partly due to cholinergic activation. [less ▲]

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See detailThe efficacy of a phyto-aromatic ear gel against auricular mange in rabbits and carnivores
Mignon, Bernard ULg; Losson, Bertrand ULg

in Veterinary Record : Journal of the British Veterinary Association (1996), 138

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See detailLa place des bisphosphonates dans le traitement de l’ostéoporose
Reginster, Jean-Yves ULg

in Lettre du Rhumatologue (La) (1996), 222

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See detailL'échec, un problème de culture pédagogique
Crahay, Marcel ULg

in Journal of Education (1996), Octobre

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See detailTreatment of osteoporosis: where are we and where are we going to
Reginster, Jean-Yves ULg

in Revista de Reumatologia (1996), 4

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See detailParticle Production in a Hadron Collider Rapidity Gap: The Higgs Case
Cudell, Jean-René ULg; Hernandez, Oscar F

in Nucl. Phys. (1996), B471

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See detailTransition probabilities for [Ni I] and [Ni II] lines
Quinet, Pascal ULg; Le Dourneuf, M

in Astronomy and Astrophysics. Supplement Series (1996), 119

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See detailStabilization of human triosephosphate isomerase by improvement of the stability of individual alpha-helices in dimeric as well as monomeric forms of the protein
Mainfroid, Véronique; Mande, Shekhar C; Hol, Wim G J et al

in Biochemistry (1996), 35(13), 4110-7

Human triosephosphate isomerase (hTIM) is a dimeric enzyme of identical subunits, adopting the alpha/beta-barrel fold. In a previous work, a monomeric mutant of hTIM was engineered in which Met14 and ... [more ▼]

Human triosephosphate isomerase (hTIM) is a dimeric enzyme of identical subunits, adopting the alpha/beta-barrel fold. In a previous work, a monomeric mutant of hTIM was engineered in which Met14 and Arg98, two interface residues, were changed to glutamine. Analysis of equilibrium denaturation of this monomeric mutant, named M14Q/R98Q, revealed that its conformational stability, 2.5kcal/mol, is low as compared to the stability of dimeric hTIM (19.3 kcal/mol). The fact that this value is also lower than the conformational stabilities usually found for monomeric proteins suggests that the hTIM monomers are thermodynamically unstable. In the present work, we attempted to stabilize the M14Q/R98Q mutant by introducing stabilizing mutations in alpha-helices of the protein. Five mutations were proposed, designed to increase alpha-helix propensity by introducing alanines at solvent-exposed sites (Q179A, K193A), to introduce favorable interactions with helix dipoles (Q179D, S105D), or to reduce the conformational entropy of unfolding by introducing proline residues at the "N-cap" position of alpha-helices (A215P). Three replacements (Q179D, K193A, and A215P) were found to increase the stability of the native dimeric hTIM and the monomeric M14Q/R98Q. These results suggest that the monomeric hTIM mutant can be stabilized to a considerable extent by following well-established rules for protein stabilization. A comparison of the stabilizing effect performed by the mutations on the dimeric hTIM and the monomeric M14Q/R98Q allowed us to reinforce a model of equilibrium denaturation proposed for both proteins. [less ▲]

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See detailLes Deux Gredins et l'Ange énonciateur
Defays, Jean-Marc ULg

in Alice (des littératures de jeunesse) (1996), 1

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See detailRegulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.
De Smedt, T.; Pajak, B.; Muraille, E. et al

in Journal of Experimental Medicine (1996), 184(4), 1413-24

Dendritic cells (DC) are described as "nature's adjuvant," since they have the capacity to sensitize T cells in vivo upon first encounter with the antigen. The potent accessory properties of DC appear to ... [more ▼]

Dendritic cells (DC) are described as "nature's adjuvant," since they have the capacity to sensitize T cells in vivo upon first encounter with the antigen. The potent accessory properties of DC appear to develop sequentially. In particular, the ability to process antigens and to sensitize native T cells develops in sequence, a process termed "maturation" that is well described in vitro. Here, we obtain evidence for maturation in vivo in response to the bacterial product lipopolysaccharide (LPS). Before LPS treatment, many DC are found at the margin between the red and white pulp. These cells lack the M342 and DEC-205 markers, but process soluble proteins effectively. 6 h after LPS, DC with the M342 and DEC-205 markers are found in increased numbers in the T cell areas. These cells have a reduced capacity to process proteins, but show increases in the B7 costimulator and T cell stimulatory capacity. 48 h after LPS, the number of DC in the spleen is reduced markedly. We interpret these findings to mean that LPS can cause DC in the marginal zone to mature and to migrate into and then out of the T cell areas. [less ▲]

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See detailCarotid Surgery in Octogenarians: Is It Worthwhile?
VAN DAMME, Hendrik ULg; Lacroix; Desiron, Quentin ULg et al

in Acta Chirurgica Belgica (1996), 96(2), 71-7

Controversy surrounds the role of carotid endarterectomy in octogenarians. Although the prognosis of severe degree carotid stenosis is more ominous in the elderly, operative risk seems more important in ... [more ▼]

Controversy surrounds the role of carotid endarterectomy in octogenarians. Although the prognosis of severe degree carotid stenosis is more ominous in the elderly, operative risk seems more important in the aged. To evaluate the presumed detrimental effect of advanced age on the mortality-morbidity of carotid endarterectomy, the authors reviewed their common experience with carotid surgery in patients aged 80 years or more. From 1980 to 1994, 129 octogenarians were operated on for occlusive carotid artery disease in two university hospitals. The data for these patients, 80 years of age and older (group 1) are compared to these for a large middle age group (less than 80 years) (group 2) operated by the same surgeons during that period. The baseline characteristics of both groups were similar, except for smoking, diabetes and previous myocardial revascularization, more prevalent in the younger age group. In the elderly group prophylactic surgery for asymptomatic stenosis was done in 36%, versus 40% of the middle aged patients, and for stroke in evolution in 8% versus 4% (p < 0.05). The perioperative stroke rate was 0.8% in the group older than 80 years, compared to 1.2% for non octogenarians (NS). The operative mortality was similar for both age groups (2.3 and 1.5 respectively). The long-term results gave a similar outlook for both age groups. The 5-year stroke-free rate reached 89% for group 1 versus 91% for group 2. The 5-year survival rate, however, was less for the elderly patients (47% versus 77%, mean follow-up periods of 30 and 49 months). These results suggest that carotid endarterectomy can be safely done in elderly patients, with a similar risk/benefit ratio as for the younger patients. Advanced age, by itself, is not to be considered as contraindication to carotid surgery. [less ▲]

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See detailThe influence of follicular dendritic cells on B-cell proliferation depends on the activation of B cells and the mitogen used.
Bosseloir, A.; Bouzahzah, F.; Defrance, T. H. et al

in Scandinavian Journal of Immunology (1996), 43(1), 23-30

Follicular dendritic cells (FDC) are unique non-lymphoid cells found only in lymph follicles. They play a part in the survival, proliferation and differentiation of B cells. To analyse the influence of ... [more ▼]

Follicular dendritic cells (FDC) are unique non-lymphoid cells found only in lymph follicles. They play a part in the survival, proliferation and differentiation of B cells. To analyse the influence of FDC on B-lymphocyte proliferation, we isolated them from human tonsils on albumin gradients and treated them with mitomycin C to prevent the multiplication of lymphoid cells harboured in their cytoplasmic evaginations. FDC cultured for 12-16 h remained attached to the substrate; non-adherent cells were carefully eliminated by washing. Purified B cells cultured alone or with contaminant-cleared FDC were maintained for 2 days in the presence or absence of various stimulants, after which tritiated thymidine uptake by these cells was measured. In the absence of activators, FDC did not induce B-cell multiplication. B cells cultured in the presence of FDC exhibited increased 3H-TdR uptake when activated with anti-CD40 MoAb, anti-immunoglobulin MoAb or transferrin, but not when stimulated with Staphylococcus aureus strain Cowan I (SAC) at a given concentration. In the latter case, B-cell proliferation clearly decreased. In control cocultures where mitomycin-C-treated non-adherent cells were used instead of FDC in the presence of the different stimulants, no increase in B-cell proliferation was observed. The results suggest that, inside the germinal centres, FDC modulation of B-cell proliferation depends on the activation state of the B cells and on the stimulant encountered. [less ▲]

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See detailThe Potent Angioinhibin Agm-1470 Stimulates Normal but Not Human Tumoral Lymphocytes
Antoine, Nadine ULg; Daukandt, M.; Locigno, R. et al

in Tumori (1996), 82(1, Jan-Feb), 27-30

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects ... [more ▼]

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects have already led to phase I clinical trials in patients with solid cancers. However, neither the exact mechanisms of action of AGM-1470 nor its effects on the host of normal cells have been extensively studied. Recently, we showed that AGM-1470 enhanced the proliferation of B lymphocytes in the presence of T cells. Since AGM-1470 could potentially be used in patients with lymphoma, it was urgent to test the effect of the molecule on the proliferation of tumor lymphocytes. METHODS: The possible effect of AGM-1470 on the proliferation of normal or tumor lymphocytes was evaluated by thymidine-incorporated assays. Normal T and B lymphocytes were purified from human tonsils. The tumor lymphocytes used in the study were Molt 3, Molt 4 and Jurkatt cell lines for the T lineage and Daudi and Radji cell lines for the B lineage. RESULTS: As shown previously, AGM-1470 stimulates the proliferation of normal B lymphocytes through an action on normal T cells. THe angioinhibin was ineffective ont eh proliferation of both T and B transformed cells. Moreover, in the presence of the drug, tumor T cells co-cultured with normal B lymphocytes did not induce any increase in B cell proliferation, as previously observed with normal T lymphocytes. Inversely, tumor B cells co-cultured with normal T lymphocytes were insensitive to the drug. CONCLUSIONS: Our results demonstrate that AGM-1470 is ineffective on lymphoid tumor cell proliferation and could potentially be safely administered to lymphoma patients. [less ▲]

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See detailUna Cabeza Bien Hecha O Una Cabeza Repleta ?
Crahay, Marcel ULg

in Perspectivas (1996), XXVI(1),

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See detail8-Chloro-5-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,5]benzodiazepine
Dupont, L.; Liégeois, Jean-François ULg; Rogister, F. et al

in Acta Crystallographica Section C-Crystal Structure Communications (1996), C52

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See detailMutations structurelles d'emploi et insertion professionnelle
Gavray, Claire ULg

in Lettre d'information TEF (1996), 4

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See detailComparison of some modules of the Lie algebra of vector fields
Lecomte, Pierre ULg; Mathonet, Pierre ULg; Tousset, E.

in Indagationes Mathematicae (1996), 7(4), 461-471

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See detailSimulation of pumping and artificial recharge in the phreatic aquifer near Bucarest (Romania)
Stefanescu, Christian; Dassargues, Alain ULg

in Hydrogeology Journal (1996), 4(3), 72-83

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See detailNew ribonucleotide reductase inhibitor, (E)-2′-deoxy-(fluromethylene) cytidine, acts as a radiosensitizer on human colon and cervix cancer cell lines
Coucke, Philippe ULg; LI, XY; Cottin, E et al

in Radiotherapy & Oncology (1996), 40(Supplément 1), 135

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See detailFormes pharmaceutiques à libération prolongée en médecine vétérinaire : systèmes à rétention dans le réticulo-rumen = Sustained-released veterinary dosage forms : retention devices in the reticulorumen
Evrard, Brigitte ULg; Delattre, Luc ULg

in STP Pharma Pratiques (1996), 6(6), 479-486

L'industrialisation des productions animales a mis en évidence la nécessité d'éviter des administrations réitérées chez des animaux dont la manipulation est difficile, et de développer des formes à ... [more ▼]

L'industrialisation des productions animales a mis en évidence la nécessité d'éviter des administrations réitérées chez des animaux dont la manipulation est difficile, et de développer des formes à libération contrôlée ou du moins fortement prolongée. L'anatomie particulière du tube digestive des ruminants offre en outre des possibilités inédites pour le développement de tels systèmes thérapeutiques, notamment grâce à la rétention dans le réticulo-rumen. De telles formes ont essentiellement été développées pour l'administration de médicaments antiparasitaires et antibactériens, de suppléments nutritionnels et de promoteurs croissance. Cette revue décrit les applications potentielles de la technologie des formes à libération contrôlée et prolongée en médecine vétérinaire et les différents dispositifs à rétention dans le réticulo-rumen décrits dans la littérature, brevetés ou commercialisés. More intensive methods ofanimal husbandry have revealed the necessity of avoiding repeated administration ofmedication to animals which are difficult to handle and of developing controlled and sustained release dosage forms. The physiological characteristics of the digestive tract of ruminants provide unique opportunity for controlled release technology, especially due to the animal's reticulo-rumen retention ability. The majorareas of application of these controlled and sustained release dosage forms include the delivery of antibiotic and antiparasitic agents, trace nutrients and growth promoting agents. This review describes the potential applications of controlled and sustained release technology in veterinary medicine and the various reticulo-rumen retention devices which are patented, marketed or described in the literature. [less ▲]

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See detailStrategic directions in concurrency research
Cleaveland, R.; Smolka, S. A.; Alur, R. et al

in ACM Computing Surveys (1996), 28(4), 607-625

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See detailChemical Composition Of Pea Fibre Isolates And Their Effect On The Endogenous Amino Acid Flow At The Ileum Of The Pig
Leterme, Pascal; Thewis, André ULg; Van leeuwen, Piet et al

in Journal of the Science of Food and Agriculture (1996), 72(1), 127-134

Pea starch, hulls and cotyledon inner fibres, isolated from pea seeds, were incorporated in N-free diets, on a NDF-content basis, in order to study their effect on the ileal endogenous amino acid (AA ... [more ▼]

Pea starch, hulls and cotyledon inner fibres, isolated from pea seeds, were incorporated in N-free diets, on a NDF-content basis, in order to study their effect on the ileal endogenous amino acid (AA) excretion in the growing pig. Maize starch and wood cellulose were selected as references. The inner fibrecontaining diet was also supplemented with enzymatically hydrolysed casein (EHC) in order to test the peptide alimentation method on a diet containing a fibre source with a high water-holding capacity (WHC = 10.9 g water g-' DM). The fibres were also analysed by different methods (crude fibre, NDF, ADF, enzymatic-gravimetric method, Englyst method). The fibre content of the inner fibre fraction varied widely from one method to another and ranged from 109 g crude fibre to 480 g AOAC fibre kg-' DM. Compared to the 'maize starch + wood cellulose' diet (11.0 g AA excreted kg-' DM intake), pea starch had no effect on ileal AA losses (9.6 g), whereas pea hulls slightly increased them (14.2 g). The AA excretion dramatically increased with the incorporation of inner fibres (28.0 g), because of their very high WHC. The addition of EHC increased the output (48.0 g) further, at a level that can hardly be explained only by an increase of the endogenous secretions. The results suggest that the NDF content of grain legume products is not indicative of their effect on the ileal endogenous AA losses in pigs and that the physiological effects of fibres along the gastrointestinal tract are due to both their chemical and physical properties. [less ▲]

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See detailCloning and expression of a new HOXC6 transcript encoding a repressing protein
Chariot, Alain ULg; Castronovo, Vincenzo ULg; Le, P. et al

in Biochemical Journal (1996), 319

Homeodomain-containing proteins are transcription factors that regulate the co-ordinated expression of multiple genes involved in development, differentiation and malignant transformation. In an attempt ... [more ▼]

Homeodomain-containing proteins are transcription factors that regulate the co-ordinated expression of multiple genes involved in development, differentiation and malignant transformation. In an attempt to characterize expressed homeobox (HOX) genes in breast cancer cells, we cloned two distinct HOXC6 transcripts from an MCF7 cDNA library, Interestingly, one of them represents a new HOXC6 mRNA encoding a homeodomain-containing protein harbouring a unique N-terminal sequence. Moreover we demonstrate that this HOXC6 transcript is less abundant in human breast cancer cells than in non-tumorigenic cell lines, is detected in breast carcinomas and adjacent tissues and is expressed in a variety of human tumours. In addition, transient co-transfection experiments illustrated that both HOXC6 transcripts encode gene products that repress transcription from a HOX binding sequence in MDA-MB231 cells and co-operate with other HOX gene products such as HOXB7 on their target genes. Taken together, our results suggest that HOXC6 proteins might contribute to the breast cell phenotype through co-operative interactions with other HOX-derived proteins and repression of their target genes. [less ▲]

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See detailThe holodisc distance transform and its applications in image analysis
Pirard, Eric ULg

in Microscopy, Microanalysis, Microstructures (1996), 7

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See detailNéphropathie tubulo-interstitielle aigue avec uvéite: à propos d'un cas
Weber, T.; Beckers, C.; Kaye, O. et al

in Acta Clinica Belgica (1996), 51(1), 53-56

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment ... [more ▼]

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment needed to reach the diagnosis. The evolution is unusually favourable with steroid therapy. [less ▲]

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See detailHeparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells.
Incardona, F.; Lawler, J.; Cataldo, Didier ULg et al

in Journal of Cellular Biochemistry (1996), 62(4), 431-42

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains ... [more ▼]

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains of thrombospondin that mediate its binding to specific receptors on the human breast adenocarcinoma cell line, MDA-MB-231. Two recombinant fragments from the amino-terminus (TSPN18 and TSPN28), and the fusion proteins of the type 1 and type 2 repeats of human thrombospondin, inhibited binding of radiolabeled thrombospondin to MDA-MB-231 cells in suspension by 40-60% at 50 micrograms/ml whereas the type 3 repeat, carboxy-terminus and unfused glutathione-S-transferase as well as the synthetic peptide Gly-Arg-Gly-Asp-Ser (500 micrograms/ml) had little or no effect. Heparin and various glycosaminoglycans as heparan sulfate, chondroitin sulfates A, B or C, and fucoidan inhibited thrombospondin binding to MDA-MB-231 cells by more than 60% whereas dextran sulfate had only little effect. Treatment of cells with heparitinase, chondroitinase ABC, and hyaluronidase, but not with neuraminidase, induced 30-50% inhibition of thrombospondin binding suggesting the participation of both heparan sulfate and chondroitin sulfate cell surface-associated molecules. Inhibition of proteoglycan sulfation by chlorate or inhibition of glycosaminoglycan chain formation by two beta-D-xylosides also led to a substantial inhibition of thrombospondin binding. Our results indicate that several domains within the thrombospondin molecule, namely the amino-terminus, type 1 and type 2 repeats, participate in its binding to specific receptors bearing sulfated glycosaminoglycans on MDA-MB-231 cells. Biological assays have indicated that, in addition to these domains, the peptide Gly-Arg-Gly-Asp-Ser inhibited MDA-MB-231 cell attachment to thrombospondin suggesting that the last type 3 repeat of the molecule may also contribute to its cell adhesive activity. [less ▲]

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See detailRadiative Lifetimes for States in Cu I
Biémont, Emile ULg; Fryczynski, F.; Palmeri, P. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (1996), 55

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See detailActualités thérapeutiques dans la thrombocytémie essentielle
Hermanne, J.-P.; Tassin, F.; Beguin, Yves ULg et al

in Médecine et Hygiène (1996), 54

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of ... [more ▼]

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of thrombocythaemia is controversial. Since th relationship of thrombosis and hemorrhage to platelet counts is not demonstrated, ther is no clear inidcation for using drugs capable of lowering platelet counts in young asymptomatic subjects. However, treatment should be offered to patients with a definite high risk of major or life-threatening hemostatic complications. The present paper reviews the incidence and risk factors for thrombotic complications and the use of medications inhibiting platelet production. [less ▲]

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See detailLocalisation respiratoire d'un lymphosarcome cutané chez un cheval.
Anciaux, Nathalie; Amory, Hélène ULg

in Pratique Vétérinaire Equine (1996), 28

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See detailStandardisation des mesures en imagerie thermique infrarouge chez les grands animaux domestiques
Ghafir, Y.; Spruyt, P.; Art, Tatiana ULg et al

in Annales de Médecine Vétérinaire (1996), 140

Thermography studies pictures recorded from radiant thermal emissions of a body. This paper analyses several measurement conditions in order to make thermographic unit reliable, ie the effects of distance ... [more ▼]

Thermography studies pictures recorded from radiant thermal emissions of a body. This paper analyses several measurement conditions in order to make thermographic unit reliable, ie the effects of distance and position of the camera, the color, lenght and power. Moreover, the effects of the site on cutaneous temperature measurements were studied in exercising horses. It can be concluded that infrared thermography is a technical to measure skin temperature which requires a few conditions to be respected. Moreover, it is a sure, simple and fast method. The ideal site for measuring skin temperature inexercising horses is the neck because of its vascularisation. [less ▲]

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See detailMagnetic texturing of bulk samples of the superconductor Bi2Sr2Ca0.8Dy0.2Cu2O8-y
Stassen, Sophie; Rulmont, André ULg; Vanderbemden, Philippe ULg et al

in Journal of Applied Physics (1996), 79(1), 553-555

The texturing process of Bi-Sr-Ca(Dy)-Cu-O (2212) is optimized by sintering under a magnetic field. The precursor crystalline powder is melted and grown under a 1.2 T magnetic field. Textured samples are ... [more ▼]

The texturing process of Bi-Sr-Ca(Dy)-Cu-O (2212) is optimized by sintering under a magnetic field. The precursor crystalline powder is melted and grown under a 1.2 T magnetic field. Textured samples are characterized by x-ray diffraction, scanning electron microscopy, electrical resistivity, and magnetic susceptibility. (C) 1996 American Institute of Physics. [less ▲]

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See detailAutologous stem cell transplantations in elderly AML patients
Archimbaud, E.; Jehn, U.; De Cataldo, F. et al

in Trends in Onco-Hematology (1996), 4(2), 28-29

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See detailDélocalisation d'une division de l'entreprise et intérêt social
Thirion, Nicolas ULg

in Revue pratique des sociétés (1996), (1), 60-90

Les titulaires d'intérêts catégoriels dans une société (tels que les travailleurs) disposent-ils d'un droit d'agir en justice au nom de l'intérêt social, à la suite de la décision de délocalisation de l ... [more ▼]

Les titulaires d'intérêts catégoriels dans une société (tels que les travailleurs) disposent-ils d'un droit d'agir en justice au nom de l'intérêt social, à la suite de la décision de délocalisation de l'activité sociétaire? [less ▲]

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See detailTwo dimensional self-organized transitions for propagation in random media
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg; Cloots, Rudi ULg

in Czechoslovak Journal of Physics (1996), 46(Suppl. 4), 2277-2278

A simple so-called dynamic epidemic model, for the evolution of an advancing interface through a two-dimensional medium containing mobile impurities is investigated. A short range repulsion between the ... [more ▼]

A simple so-called dynamic epidemic model, for the evolution of an advancing interface through a two-dimensional medium containing mobile impurities is investigated. A short range repulsion between the front and the impurities leads to an aggregation process along the front, and to trapping of aggregates. The pattern of trapped impurities is found to be self-organized. The critical concentration of impurity for growth blocking on a square lattice is 0..56. The kinetics of this self-organization is analyzed and discussed. [less ▲]

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See detailInfluence of thermal acclimation on the survival of Sitophilus granarius (L) and Oryzaephilus surinamensis (L) at low temperatures
Mignon, Jacques ULg; Haubruge, Eric ULg; Gaspar, Charles ULg

in Netherlands Journal of Zoology (1996), 46(3-4), 317-325

Low temperatures have been used for many years to control populations of stored-product insects. The aim of aeration was primarily to cool down the grain and then to prevent its deterioration by reducing ... [more ▼]

Low temperatures have been used for many years to control populations of stored-product insects. The aim of aeration was primarily to cool down the grain and then to prevent its deterioration by reducing the number of insects. In Belgium, the mild winters enable insects to survive to the next season. In autumn, the progressive lowering of temperature has an acclimation effect on stored-product insects. The present study was undertaken to determine the survival at low temperatures of non cold-acclimated and laboratory- and field-cold-acclimated insects. We have chosen to work with the granary weevil Sitophilus granarius (L.) and the saw-toothed grain beetle Oryzaephilus surinamensis (L.). They are the most frequent stored-grain pests in Belgium. To compare the cold-hardiness of different laboratory cold-acclimated insects, S. granarius and O. surinamensis were placed at nine different cold-acclimation temperature regimes. Insects were kept at 5 degrees C for 2, 4 and 6 weeks or at -5 degrees C for 4, 7 and 14 days. To assess the field-cold-acclimation in autumn and in winter, insects were monthly taken from a bin and transferred to 5 degrees C for 6 weeks. S. granarius adults were more cold-hardy than O. surinamensis, but O. surinamensis adults compensated their cold-sensibility by a great ability to acclimate. S. granarius is able to survive the winter in Belgium because of its cold-hardiness while O. surinamensis survives because of its ability to acclimate to low temperatures. [less ▲]

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See detailBiogeography and taxonomy of Apodemus sylvaticus (the woodmouse) in the Tyrrhenian region: Enzymatic variations and mitochondrial DNA restriction pattern analysis
Michaux, Johan ULg; Filippucci, M. G.; Libois, Roland ULg et al

in Heredity (1996), 76(Part 3), 267-277

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown ... [more ▼]

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown in geographical terms. In order to examine the level of genetic relatedness of insular and continental woodmice, 258 animals were caught in 24 localities distributed in Belgium, France, mainland Italy, Sardinia, Corsica and Elba. Electrophoresis of 33 allozymes and mtDNA restriction fragments were performed and a UPGMA dendrogram built from the indices of genetic divergence. The dendrogram based on restriction patterns shows two main groups: 'Tyrrhenian', comprising all the Italian and Corsican animals and 'North-western', corresponding to all the other mice trapped from the Pyrenees to Belgium. Since all the Tyrrhenian mice are similar and well isolated from their relatives living on the western edge of the Alpine chain, they must share a common origin. The insular populations are consequently derived from peninsular Italian ones. From a taxonomic point of view and taking the priority rules into account, we have to invalidate A. s. clanceyi Harrison, 1948 and to consider the Tyrrhenian woodmice as belonging to A. s. milleri de Beaux, 1926, whereas the North-western ones must be referred to as the nominal subspecies. As far as the Elban woodmouse is concerned, at the moment we prefer to keep its present subspecific status because we only studied one animal. [less ▲]

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See detailLe fonctionnement de la mémoire à court terme auditive-vocale dans le syndrome de Down : Implications pour le modèle de mémoire de travail
Comblain, Annick ULg

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (1996), 8(4-5), 137-147

Since the end of the sixties, number of studies have put in obviousness that the short-term memory span of mentally retarded subjects remains largely below the level expected regarding their mental age ... [more ▼]

Since the end of the sixties, number of studies have put in obviousness that the short-term memory span of mentally retarded subjects remains largely below the level expected regarding their mental age and their chronological age. Mackenzie and Hulme (1987) and Hulme and Mackenzie (1992), for example, showed that verbal short-term memory abilities of mentally retarded subjects do not develop at the same rate than other cognitives aspects. These results provide important information on the development of memory span in those subjects but do not provide information on the functioning of the different components of their verbal short-term memory. We conducted several experiments in order to supply with this deficit and to describe the functioning of the verbal short-term memory in a group of Down's syndrome subjects. Our data put in obviousness the similarity of verbal short-term memory's functioning in Down's syndrome subjects and in normal children (phonological similarity effect and word length effect). The absence of a significant correlation between articulation rate and memory span in Down's syndrome people (like in less than 6 years old normal children, see Gathercole et al., 1993, 1994) leads us to discuss a central point of the working memory model (Baddeley, 1986). [less ▲]

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See detailHybridization of 2,659 Clostridium Perfringens Isolates with Gene Probes for Seven Toxins (Alpha, Beta, Epsilon, Iota, Theta, Mu, and Enterotoxin) and for Sialidase
Daube, Georges ULg; Simon, Patricia ULg; Limbourg, Bernard et al

in American Journal of Veterinary Research (1996), 57(4), 496-501

OBJECTIVE--To genetically characterize Clostridium perfringens isolates for association of pathologic type with various diseases. DESIGN--Prospective study. SAMPLE POPULATION--2,659 C perfringens isolates ... [more ▼]

OBJECTIVE--To genetically characterize Clostridium perfringens isolates for association of pathologic type with various diseases. DESIGN--Prospective study. SAMPLE POPULATION--2,659 C perfringens isolates from various nonhuman animals species, human beings, and foods. PROCEDURE--Colony hybridization with DNA probes for 7 toxin (alpha, beta, epsilon, iota (subunits a and b), theta, mu, and enterotoxin) genes and 1 sialidase gene were performed to group the isolates by pathologic type. RESULTS--Enterotoxin-negative type-A isolates were the most common (2,575/2,659), were isolated from all sources, and were separated into 5 pathologic types. In cattle and horses with enterotoxemia, essentially only these pathologic types were identified. The enterotoxin-negative isolates of types C or D each had a single pathologic type. Type-C isolates were isolated only from swine with necrotic enteritis and type-D isolates from small ruminants with enterotoxemia, except that 1 type-D isolate was also found from a healthy fish. Type-B or -E isolates were not found. Among the 47 enterotoxin-positive isolates, 5 isolates from sheep or deer were type D and the other 42 were type A. These 42 isolates were grouped into 3 pathologic types: 1 type was isolated from samples of almost all origins, but the other 2 types were found in only 5 fish, 4 human beings, and 1 dog. CONCLUSIONS AND CLINICAL RELEVANCE--Genetic characterization of these isolates allowed identification of 11 different pathologic types. This approach may be useful in molecular diagnosis and prophylaxis of clostridial disease. [less ▲]

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See detailNew bisphosphonates for the treatment of osteoporosis : concerns and hopes
Reginster, Jean-Yves ULg

in Revue du Rhumatisme (English ed.) (1996), 63(7-8), 461-464

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See detailCurrent therapies for shingles
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Expert Opinion on Investigational Drugs (1996), 5

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but ... [more ▼]

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but its moderate bioavailability renders five oral daily doses mandatory. Recent anti-VZV drug research has been oriented towards agents with increased oral bioavailability. Famciclovir and valaciclovir were originally developed as oral prodrugs for^penciclovir and acyclovir, respectively, but, together with the new antivirals, sorivudine and brovavir, they appear to be effective as oral therapy for shingles. Ongoing clinical trials will determine their relative merits in the management of shingles. The experimental agents H2G, HPMPC, mappicine ketone and A-73209 have potential in the treatment of VZV and are undergoing further investigation and development. [less ▲]

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See detailInfections oculaires traumatiques et iatrogènes: prélèvements et rôle du laboratoire
Melin, Pierrette ULg

in Bulletin de la Société Belge d'Ophtalmologie (1996), 260

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological ... [more ▼]

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological diagnostic. The indications and techniques for investigations are determined by the site of infection, severity of the process, and knowledge of the likely responsible organisms. Immediate inoculation of specimens on culture media in the examining room is often recommended. This article describes organisms associated with ocular infections, and is designed to assists ophthalmologists in the collection, processing and transport of specimens. [less ▲]

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See detailImpact of the microbiology in the epuration processes.
Thonart, Philippe ULg; Destain, Jacqueline ULg; Antoine, Patrice et al

in Cerevisia and Biotechnology (1996), 21(2), 76-79

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at ... [more ▼]

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at very low concentrations of pollutants. Two approaches can be considered for developing biological processes of epuration : addition of bioactivators for improving endogenous microorganisms capabilities or introduction of microorganism starters for accelerating the epuration process. These two ways need as prerequisite a basic knowledge of the metabolic pathways for specific compound degradation and of microbial ecology [less ▲]

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See detailDNA bending by the silencer protein NeP1 is modulated by TR and RXR.
Arnold, R.; Burcin, M.; Kaiser, Bruno ULg et al

in Nucleic Acids Research (1996), 24(14), 2640-7

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing ... [more ▼]

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing mechanism acting independently of the relative promoter position. Here we show that NeP1 alone can induce a significant directed bend on DNA. The chicken homologue of human NeP1, CTCF, shows identical binding and bending properties. In contrast, the isolated DNA binding domain of CTCF efficiently binds DNA, but fails to confer bending. Similarly, the TR-RXR hetero- or homodimer, binding adjacent to NeP1 at the F2 sequence, do not show significant DNA bending. The binding of the T3 ligand to TR changes neither the magnitude nor the direction of the NeP1 induced bend. However, when all factors are bound simultaneously as a quaternary complex, the TR-RXR heterodimer changes the location of the bend center, the flexure angle and the bending direction. [less ▲]

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See detailL’éducation géographique. Pour une vision citoyenne du monde
Merenne-Schoumaker, Bernadette ULg

in Géographes Associés (1996), (19), 65-69

Brief reflection on the place of the teaching of geography in education for citizenship

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See detailThe development of a European questionnaire for quality of life in patients with vertebral osteoporosis
Lips, P; Agnusdei, D; Caulin, F et al

in Scandinavian Journal of Rheumatology (1996), 25(103), 84-85

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See detailYounger age as a bad prognostic factor in patients with carcinoma of the cervix.
Delaloye, J-F; Pampallona, S; COUCKE, Philippe ULg et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (1996)

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre ... [more ▼]

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre Hospitalier Universitaire Vaudois of Lausanne were subdivided according to the following age categories: _<45, 46-60, 61-69 and > 70 years. Taking the 46-60 years age group as the reference, the hazard ratios (HR) of death and corresponding 95% confidence intervals (95% CI) were estimated by means of a Cox multivariate analysis. Results: The 5-year survival rates were, respectively, 57%, 67%, 60% and 45%. For the youngest women the risk of death was significantly increased (HR = 2.00, 95% CI [1.32-3.00]) and was even more accentuated in advanced stages. Conclusion: Age under 45 years is a bad prognostic factor in carcinoma of the cervix. [less ▲]

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See detailInhibition of Paf-Induced Platelet Aggregation by Web 2086 'in-Vitro', an Antagonist to the Receptor for Platelet-Activating Factor, in Bovine
Bastos da Silva, Miriam; Herion, Francine ULg; Raskinet, Renée ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1996), 43(7), 399-413

The sensitivity of bovine platelet aggregation in response to PAF stimulation and the ability of WEB 2086 (a thieno-triazolodiazepine) to inhibit response to PAF-induced platelet aggregation were ... [more ▼]

The sensitivity of bovine platelet aggregation in response to PAF stimulation and the ability of WEB 2086 (a thieno-triazolodiazepine) to inhibit response to PAF-induced platelet aggregation were investigated in the blood from five healthy male Belgian Blue calves. The recorded response to PAF showed a plateau which was dependent on the PAF concentration. Platelet aggregation induced by PAF consists of two mechanisms: reversible and irreversible aggregations which are accompanied by the release of platelet granule contents. Reversible aggregation occurred above (2 . 10(-9) mol/l) PAF, and irreversible aggregation occurred above (2 . 10(-7) mol/l) PAF. Addition of WEB 2086 to bovine platelets in vitro induced a rightward shift in the dose-response curve to PAF. WEB 2086 inhibited PAF-induced aggregation in a competitive reversible manner (pA2 = 7.61). The results of our study show that PAF induces platelet aggregation in platelet-rich plasma (PRP) and that addition of WEB 2086 to bovine platelets in vitro inhibits PAF-induced Platelet Aggregation. [less ▲]

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See detailA comprehensive pollen- and tephra- based chronostratigraphic model for the Late Glacial and Holocene Period in the French Massif Central.
Juvigné, Etienne ULg; Bastin, B; Delibrias, G et al

in Quaternary International (1996), 34-36

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See detailHeparin-coated Palmaz-Schatz stents in human coronary arteries. Early outcome of the Benestent-II Pilot Study.
Serruys, P. W.; Emanuelsson, H.; van der Giessen, W. et al

in Circulation (1996), 93(3), 412-22

BACKGROUND: The purpose of the Benestent-II Pilot Study was to evaluate the safety of delaying and eliminating anticoagulant therapy in patients receiving a heparin-coated stent in conjunction with ... [more ▼]

BACKGROUND: The purpose of the Benestent-II Pilot Study was to evaluate the safety of delaying and eliminating anticoagulant therapy in patients receiving a heparin-coated stent in conjunction with antiplatelet drugs. METHODS AND RESULTS: The study consisted of three initial phases (I, II, III) during which resumption of heparin therapy after sheath removal was progressively deferred by 6, 12, and 36 hours. In phase IV, coumadin and heparin were replaced by 250 mg ticlopidine and 100 mg aspirin. Of the 207 patients with stable angina pectoris and a de novo lesion in whom heparin-coated stent implantation was attempted, implantation was successful in 202 patients (98%). Stent thrombosis did not occur during all four phases, and the overall clinical success rate at discharge was 99%. Bleeding complications requiring blood transfusion or surgery fell from 7.9% in phase I to 5.9%, 4%, and 0% in the three following phases. Hospital stay was 7.4, 6.1, 7.2, and 3.1 days for the consecutive phases. The restenosis rate for the combined four phases was 13% (15% in phase I, 20% in phase II, 11% in phase III, and 6% in phase IV). The overall rate of reintervention for the four phases was 8.9%. At 6 months, 84%, 75%, 94%, and 92% of the patients of phases I to IV, respectively, were event free. For the four phases, the event-free rate was 86%, which compares favorably with the rate observed in the Benestent-I study (80%; relative risk, 0.68 [0.45 to 1.04]). CONCLUSIONS: The implantation of stents coated with polyamine and end-point-attached heparin in stable patients with one significant de novo coronary lesion is well tolerated, is associated with no (sub)acute stent thrombosis, and results in a favorable event-free survival after 6 months. [less ▲]

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See detailPerforation Strength of Geosynthetics and Sphericity of Coarse Grains: a new approach
Courard, Luc ULg; Antoine, R.

in Geotextiles & Geomembranes (1996), 14

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See detailAn efficient procedure for the production of fatty acid hydroperoxides from hydrolyzed flax seed oil and soybean lipoxygenase.
Fauconnier, Marie-Laure ULg; Marlier, M.

in biotechnology techniques (1996), 10(11), 839-844

Production of 13-linolenic acid hydroperoxides Tom hydrolyzed flax seed oil using lipoxygenase extracted Tom soybean seedshas been achieved with high transformation yields (60 g.l.-1h-1) with a high ... [more ▼]

Production of 13-linolenic acid hydroperoxides Tom hydrolyzed flax seed oil using lipoxygenase extracted Tom soybean seedshas been achieved with high transformation yields (60 g.l.-1h-1) with a high purity (94 % of i3-isomers) in a 10 liter reactor without addition of any solvent or surfactant. The reaction limiting factor is, probably, the accessibility of the substrate to the enzyme. [less ▲]

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See detailLa bryoflore d'une mosaïque alluviale rhénane: la réserve naturelle de la Petite Camargue Alsacienne (Haut-Rhin)
Vanderpoorten, Alain ULg; Klein, J. P.; Jaegly, E. et al

in Bulletin de la Société Botanique du Centre-Ouest (1996), 27

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See detailA Non-Cofactor Role of Thiamine Derivatives in Excitable Cells?
Bettendorff, Lucien ULg

in Archives of Physiology & Biochemistry (1996), 104(6), 745-751

Thiamine diphosphate (TDP) is an important cofactor of pyruvate (PDH) and alpha-ketoglutarate (KGDH) dehydrogenases and transketolase. Thiamine deficiency leads to reversible and irreversible brain ... [more ▼]

Thiamine diphosphate (TDP) is an important cofactor of pyruvate (PDH) and alpha-ketoglutarate (KGDH) dehydrogenases and transketolase. Thiamine deficiency leads to reversible and irreversible brain lesions due to impaired oxidative metabolism. A specific non-cofactor role for thiamine has also been proposed in excitable cells and thiamine triphosphate (TTP) might be involved in the regulation of ion channels. Thiamine is taken up by neuroblastoma cells through a high affinity transporter. Inside the cells, it is rapidly phosphorylated to TDP. This high turnover TDP pool is the precursor for TTP. Most of the TDP however has a low turnover and is associated with PDH and KGDH in mitochondria. In excised inside-out patches from neuroblastoma cells, TTP, at a concentration of 1 microM, activates chloride channels of large unitary conductance, the so-called maxi-Cl- channels. These channels are inhibited by oxythiamine from the outide. In addition to the role of TTP in the regulation of chloride channels, thiamine itself, or a presently unknown analog, may have trophic effects on neuronal cells. [less ▲]

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See detailCase management voor psychogeriatrishe patiënten: gezondheidstoestand van deze ouderen en de zorgbelasting van hun centrale verzorgers
Milisen, K.; Borgermans, L.; Dejace, Alain ULg et al

in Acta Hospitalia (1996), 4

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See detailEnergy levels and oscillator strengths for transitions in Pd II
Quinet, Pascal ULg

in Physica Scripta (1996), 54

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See detailUsefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study.
Daubresse, Jean-Claude; Kolanowski, J.; Krzentowski, G. et al

in Obesity Research (1996), 4(4), 391-6

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent ... [more ▼]

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent diabetics, moderately obese (BMI = 30 - 39 kg/m2), were given for an 8-week period either placebo (P) or fluoxetine (F), a specific serotonin reuptake inhibitor, in addition to their usual antidiabetic treatment. Thirty-nine of them received 60 mg fluoxetine a day and 43 were given the placebo. At admission, both groups had similar weight excess, metabolic control and serum lipid values. In comparison with the P-treated subjects, those treated with fluoxetine (F) lost more weight after 3 weeks (-1.9 vs. -0.7 kg, p < -0.0009) and after 8 weeks (-3.1 vs. -0.9 kg, p < 0.0007). Fasting blood glucose decreased in group F after 3 weeks (-1.5 vs -0.4 mmol/L, p < 0.003) and after 8 weeks (-1.7 vs. -0.02 mmol/L, p < 0.0004). HbAlc decreased from 8.5% to 7.7% in group F and from 8.6% to 8.3% in group P (p = 0.057). Mean triglyceride level was also reduced in group F after 8 weeks (p = 0.042). Fasting C-peptide did not change in either group, but fasting insulin values decreased in group F after 3 weeks (p < 0.02) and after 8 weeks (p < 0.05). The insulin/C-peptide molar ratio decreased significantly in group F after 3 weeks (p < 0.04) and after 8 weeks (p < 0.05) in comparison with group P. The drug was generally well tolerated and no major side effects were reported. In conclusion, the addition of fluoxetine to the usual oral hypoglycemic agent therapy might be beneficial in obese non-insulin-dependent diabetics, at least on a short-term basis. [less ▲]

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See detailHigh neuron specific enolase levels in bronchoalveolar lavage fluid of patients with lung carcinoma: diagnostic value, relation to serum neuron specific enolase, and staging.
Dowlati, A; Bury, Thierry ULg; CORHAY, Jean-Louis ULg et al

in Cancer (1996), 77(10), 2039-43

BACKGROUND: High levels of neuron specific enolase (NSE) have recently been described in the bronchoalveolar lavage (BAL) fluid of patients with lung carcinoma. Although its value in serum has been ... [more ▼]

BACKGROUND: High levels of neuron specific enolase (NSE) have recently been described in the bronchoalveolar lavage (BAL) fluid of patients with lung carcinoma. Although its value in serum has been extensively studied, its diagnostic value in BAL fluid in terms of sensitivity, specificity, and predictive value have not been evaluated. In addition, its value in staging and relation to serum NSE are yet unknown. METHODS: NSE levels were determined on the same day in the BAL fluid and the sera of two groups of patients: those with newly diagnosed lung carcinoma and those with smoking related chronic obstructive pulmonary disease (COPD). Clinical TNM staging was also performed. Levels of NSE in BAL fluid were expressed as nanograms per 100 international units of lactate dehydrogenase. BAL fluid NSE levels of the two groups were compared with staging and serum NSE. RESULTS: A highly significant difference exists in BAL NSE in the two groups. For diagnostic purposes, the simultaneous measurements of serum NSE increases its sensitivity, but specificity remains unchanged. No correlation exists between BAL NSE and serum NSE, tumor size, nodal status, or the presence of metastases. BAL NSE is a better predictor of malignancy than serum NSE. CONCLUSION: BAL fluid measurements of NSE may have diagnostic value, specially if it is simultaneously measured in the serum. However, our study does not show any value for this technique in staging of lung carcinoma. Also it has no correlation with serum NSE. Studies will have to be performed to determine if BAL NSE can predict chemotherapeutic sensitivity. [less ▲]

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See detailFalls among the elderly: a community problem
Reginster, Jean-Yves ULg; Gosset, Christiane ULg; Reginster-Haneuse, G.

in Archives of Public Health (1996), 54

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See detailA systematic view on medical informatics.
Hasman, A; Haux, R; Albert, Adelin ULg

in Computer Methods & Programs in Biomedicine (1996), 51(3), 131-9

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics ... [more ▼]

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics (including health informatics), its aim, methods and tools, and its relevance to other disciplines in medicine and health sciences are outlined. It is recognized that one of the major tasks of medical informatics is modelling processes. In this context, biological, communication, decision, engineering, educational, organizational and computational processes are distinguished and described. [less ▲]

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See detailA simple technique to relieve Tribolium castaneum (Coleoptera: Tenebrionidae) of Acarophenax tribolii (Acarina: Pyemotidae).
Arnaud, Ludovic; Mignon, Jacques ULg; Gilson, Jean-Claude et al

in Tribolium Information Bulletin (1996), 36

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See detailCloning, sequencing and overexpression in Escherichia coli of the alginate lyase-encoding aly gene of Pseudomonas alginovora: identification of three classes of alginate lyases
Chavagnat, Frederic; Duez, Colette ULg; Guinand, Micheline et al

in Biochemical Journal (1996), 319(Pt 2), 575-583

A gene of Pseudomonas alginovora, called aly, has been cloned in Escherichia coli using a battery of PCR techniques and sequenced. It encodes a 210-amino-acid alginate lyase (EC 4.2.2.3), Aly, in the form ... [more ▼]

A gene of Pseudomonas alginovora, called aly, has been cloned in Escherichia coli using a battery of PCR techniques and sequenced. It encodes a 210-amino-acid alginate lyase (EC 4.2.2.3), Aly, in the form of a 233-amino-acid precursor. P. alginovora Aly has been overproduced in E. coli with a His-tag sequence fused at the C-terminal end under conditions in which the formation of inclusion bodies is avoided. His-tagged P. alginovora Aly has the same enzymic properties as the wild-type enzyme and has the specificity of a mannuronate lyase. It can be purified in a one-step procedure by affinity chromatography on Ni(2+)-nitriloacetate resin. The yield is of 5 mg of enzyme per litre of culture. The amplification factor is 12.5 compared with the level of production by wild-type P. alginovora. The six alginate lyases of known primary structure fall into three distinct classes, one of which comprises the pair P. alginovora Aly and Klebsiella pneumoniae Aly. [less ▲]

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See detailDeffand, Marie de Vichy-Chamrond, marquise du
Tilkin, Françoise ULg

in Voir barré (1996), 12-13

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See detailWhat policies for biodiversity management in the Wallonia region? Biodiversity and its audiences: Sociological reflections on biodiversity protection
Mormont, Marc ULg

in Annales de Gembloux (1996), 102(1-2), 19-30

Current popular concepts of biodiversity are examined, with particular application to Belgium, using a three stage analysis. The way in which the link was made between a scientific concept and a ... [more ▼]

Current popular concepts of biodiversity are examined, with particular application to Belgium, using a three stage analysis. The way in which the link was made between a scientific concept and a sociopolitical definition is analysed. Consideration is made of society's idea of 'nature' and the 'return to nature' concept. Ways in which the public can adapt its behaviour and ideals to protect biodiversity (local ecology programmes, environmentally friendly farming etc) are examined. [less ▲]

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See detail"Aquí, allá y en todas partes": La (con)version de la Identidad Caribeña por Michelle Cliff
Ledent, Bénédicte ULg; Ortega, María Teresa

in Anales del Caribe (1996), 16-18

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See detailPolymerization of β-butyrolactone initiated with Al(OiPr)3
Kurcok, Piotr; Dubois, Philippe ULg; Jérôme, Robert ULg

in Polymer International (1996), 41(4), 479-485

Polymerization of gamma-butyrolactone has been studied in toluene with Al(OiPr)3 as an initiator. The ring-opening polyaddition proceeds through a coordination-insertion mechanism at a very low rate. Well ... [more ▼]

Polymerization of gamma-butyrolactone has been studied in toluene with Al(OiPr)3 as an initiator. The ring-opening polyaddition proceeds through a coordination-insertion mechanism at a very low rate. Well defined -isopropylester, -hydroxy poly(-butyrolactone)s (PBL) are formed with a narrow molecular weight distribution at low monomer-to-initiator molar ratios, When this ratio is higher (ca. 170), a competition occurs between propagation and side reactions, i.e. elimination, inter- and intra-molecular transesterifications and thermal degradation, which is responsible for a loss of control of the PBL molecular charcteristics. The addition of a Lewis base (1 equivalent of nicotine/Al) to the Al-alkoxide initiator has no significant effect on the polymerization rate, although the chain microstructure is deeply affected since predominantly syndiotactic PBL chains are formed (63% syndio-diads) in contrast to a completely atactic polymer in the absence of nicotine. [less ▲]

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See detailCalcitonin
Reginster, Jean-Yves ULg

in Current Opinion in Orthopaedics (1996), 7

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See detailSexual differentiation of odor and partner preference in the rat.
Bakker, Julie ULg; Van Ophemert, J.; Slob, A. K.

in Physiology & Behavior (1996), 60(2), 489-94

Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an ... [more ▼]

Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an altered sexual partner preference. When tested in a three-compartment box, such gonadally intact ATD males approach and mate both with the estrous female and the sexually active male, whereas normal males prefer to approach and mate with the estrous female, avoiding the stimulus male. After castration in adulthood and estradiol treatment, ATD males prefer sexually active males. Similarly treated normal males prefer estrous females, and estrous females prefer to mate with males. In the present study, we asked what stimulus characteristics of active males vs. estrous females determined the different sexual preferences of males, ATD males, and of females. Were they chemosensory cues or more distal cues such as actually seeing and hearing the stimulus animals or the reward of sexual activity with the stimulus animals? Sex differences in preference were evident when animals were given a choice between soiled bedding from estrous females and from sexually active males. ATD and control males spent significantly more time on soiled bedding from estrous females than on soiled bedding from sexually active males. Control females spent significantly more time on soiled bedding from sexually active males than on soiled bedding from estrous females. More distal cues, such as seeing and hearing the stimulus animals, revealed differences in preference between control males and females, but not between ATD and control males. Physical interaction with the stimulus animals was a prerequisite for revealing differences in preference between ATD and control males. Then, the behavior of ATD males was clearly intermediate between that of normal male and female rats. In conclusion, neonatal estradiol is important for the psychosexual development of the male rat. However, the present data suggest that the psychosexual development of the male rat also requires either prenatal estradiol or perinatal testosterone. [less ▲]

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See detailPremière approche de la flore macrolichénique corticole de la Région de Bruxelles-Capitale en situation de dépollution au SO2
Tanghe, Martin; Richel, Thierry; Crisan, Florin et al

in Belgian Journal of Botany (1996), 129

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See detailDivorce et annulation du mariage simulé
Paris, Catherine ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1996)

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See detailCrystallization and preliminary X-ray diffraction studies of a-amylase from the antarctic psychrophile Alteromonas haloplanctis A23
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (1996), 5(10), 2128-2129

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the ... [more ▼]

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the molecular basis of cold adaptations, crystallographic studies of this cold-adapted enzyme have been initiated because a three-dimensional structure of a mesophilic counterpart, pig pancreatic alpha-amylase, already exists. alpha-Amylase from A. haloplanctis, which shares 53% sequence identity with pig pancreatic alpha-amylase, has been crystallized and data to 1.85 A have been collected. The space group is found to be C222(1) with a = 71.40 A, b = 138.88 A, and c = 115.66 A. Until now, a three-dimensional structure of a psychrophilic enzyme is lacking. [less ▲]

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See detailRecent advances in prostate cancer metastasis
Waltregny, David ULg; Castronovo, Vincenzo ULg

in Tumori (1996), 82(3, May-Jun), 193-204

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy ... [more ▼]

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy that exists between the prevalence of 'latent' cancer, recognizable only histologically, and that of the clinical disease. Histologically detected localized prostate cancers are heterogeneous, with only a small subset having undergone all of the malignant changes required to produce clinically aggressive tumors. Most of these 'latent' carcinoma never become fully malignant and do not threaten the life or well-being of the host. At present, it is not possible to predict which localized cancers will progress to clinically overt disease. Likewise, many patients have underevaluated and unpredictable extent of their prostate carcinoma, thus resulting in inadequate therapeutic strategies. It is clear that we need to identify molecular and/or cellular markers that are able to define the invasive and metastatic potential of prostate cancer on an individual patient basis. Acquisition of metastatic ability is a definitive criterion by which substage localized prostate cancers. Under the light of recent studies designed to identify some of the features associated with the metastatic phenotype of prostate cancer, the authors review recent advances aimed at gaining insight into those factors that may be involved in prostate cancer metastasis. [less ▲]

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See detailThe lichen genus Lecanactis and allied genera in Papua New Guinea
Egea, J.M.; Sérusiaux, Emmanuël ULg; Torrente, Pilar

in Mycotaxon (1996), 59

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See detailRelationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines
Creuven, Isabelle; Evrard, Christine ULg; Olivier, Anne et al

in Antiviral Research (1996), 30

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the ... [more ▼]

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the different affinity of the compounds for the herpes simplex virus type 1 (HSV-1) thymidine kinase. These compounds present a variable affinity according to the position of the heteroatom substituting the five-membered ring. An unfavourable substitution in the five-membered ring for interaction with the HSV-1 thymidine kinase has been identified. [less ▲]

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See detailMutation analysis of the pyruvate dehydrogenase E1 alpha gene in eight patients with a pyruvate dehydrogenase complex deficiency.
Lissens, W.; De Meirleir, L.; Seneca, S. et al

in Human mutation (1996), 7(1), 46-51

Most of the mutations causing deficiency of the pyruvate dehydrogenase (PDH) complex are in the X-linked E1 alpha gene. We have developed a rapid screening method for the detection of mutations in this ... [more ▼]

Most of the mutations causing deficiency of the pyruvate dehydrogenase (PDH) complex are in the X-linked E1 alpha gene. We have developed a rapid screening method for the detection of mutations in this gene using reverse transcription of total RNA, polymerase chain reaction amplification of the whole coding region of the gene and single-strand conformation polymorphism (SSCP) analysis. With this method, we studied eight patients with a PDH complex deficiency, using cultured fibroblasts. In all patients, aberrant SSCP patterns were found and, after sequencing of the corresponding fragments, we were able to identify six new mutations and two mutations already described previously. The mutations are point mutations leading to amino acid substitutions (5) and direct repeat insertions (3). The presence of the mutations was confirmed in genomic fibroblast DNA. The 4 female patients were shown to carry both a normal and a mutated E1 alpha gene. [less ▲]

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See detailClinical pharmacokinetics of metformin.
Scheen, André ULg

in Clinical Pharmacokinetics (1996), 30(5), 359-71

The biguanide metformin (dimethylbiguanide) is an oral antihyperglycaemic agent widely used in the management of non-insulin-dependent diabetes mellitus (NIDDM). Considerable renewal of interest in this ... [more ▼]

The biguanide metformin (dimethylbiguanide) is an oral antihyperglycaemic agent widely used in the management of non-insulin-dependent diabetes mellitus (NIDDM). Considerable renewal of interest in this drug has been observed in recent years. Metformin can be determined in biological fluids by various methods, mainly using high performance liquid chromatography, which allows pharmacokinetic studies in healthy volunteers and diabetic patients. Metformin disposition is apparently unaffected by the presence of diabetes and only slightly affected by the use of different oral formulations. Metformin has an absolute oral bioavailability of 40 to 60%, and gastrointestinal absorption is apparently complete within 6 hours of ingestion. An inverse relationship was observed between the dose ingested and the relative absorption with therapeutic doses ranging from 0.5 to 1.5 g, suggesting the involvement of an active, saturable absorption process. Metformin is rapidly distributed following absorption and does not bind to plasma proteins. No metabolites or conjugates of metformin have been identified. The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin. Metformin undergoes renal excretion and has a mean plasma elimination half-life after oral administration of between 4.0 and 8.7 hours. This elimination is prolonged in patients with renal impairment and correlates with creatinine clearance. There are only scarce data on the relationship between plasma metformin concentrations and metabolic effects. Therapeutic levels may be 0.5 to 1.0 mg/L in the fasting state and 1 to 2 mg/L after a meal, but monitoring has little clinical value except when lactic acidosis is suspected or present. Indeed, when lactic acidosis occurs in metformin-treated patients, early determination of the metformin plasma concentration appears to be the best criterion for assessing the involvement of the drug in this acute condition. After confirmation of the diagnosis, treatment should rapidly involve forced diuresis or haemodialysis, both of which favour rapid elimination of the drug. Although serious, lactic acidosis due to metformin is rare and may be minimised by strict adherence to prescribing guidelines and contraindications, particularly the presence of renal failure. Finally, only very few drug interactions have been described with metformin in healthy volunteers. Plasma levels may be reduced by guar gum and alpha-glucosidase inhibitors and increased by cimetidine, but no data are yet available in the diabetic population. [less ▲]

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See detailOscillator strengths for Ca-like iron, cobalt and nickel (Fe VII, Co VIII, Ni IX)
Quinet, Pascal ULg; Hansen, J E

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailA. Kastler (1902-1984)
Biémont, Emile ULg; Glansdorff, P.

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1996), 6e série(VII), 131-149

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See detailChronic Exposure of Pigs to Airborne Dust and Endotoxins in an Environmental Chamber: Technical Note
Urbain, B.; Prouvost, J. F.; Beerens, Dominique ULg et al

in Veterinary Research (1996), 27(6), 569-578

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were ... [more ▼]

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were evaluated in a chamber containing two pigs of 10 kg body-weight: inhalable and respirable dust gravimetric concentrations were measured using area samplers and expressed as mg/m3. The respirable dust concentration was also measured using a "TM digital microP respirable dust-measuring instrument', which has been shown to give similar results to the gravimetric method. The endotoxin concentration was evaluated using the Limulus-assay and expressed as ng/m3 of air containing the inhalable or respirable dust or as ng/mg of inhalable and respirable dust. Feed flour dust was introduced into the chamber to obtain different concentrations of inhalable and respirable dust ranging from 3.62 to 76.66 mg/m3 and from 0.24 to 1.40 mg/m3, respectively. The endotoxin concentration was modulated by mixing the feed flour with Escherichia coli endotoxins before blowing it into the chamber. The endotoxin concentrations in the air containing inhalable or respirable dust ranged from 28.9 to 270.0 ng/m3 and from 2.22 to 36.38 ng/m3, respectively, depending on the amount of endotoxins added to the dust. Data were also obtained in a piggery. The experimental setup detailed in this paper could be used to study the significance of air contaminants in the development of pig respiratory diseases. [less ▲]

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See detailAlterations in the ultradian oscillations of insulin secretion and plasma glucose in aging.
Scheen, André ULg; Sturis, J.; Polonsky, K. S. et al

in Diabetologia (1996), 39(5), 564-72

Normal insulin secretion includes oscillations with a period length of 80-150 min which are tightly coupled to glucose oscillations of similar period. To determine whether normal aging is associated with ... [more ▼]

Normal insulin secretion includes oscillations with a period length of 80-150 min which are tightly coupled to glucose oscillations of similar period. To determine whether normal aging is associated with alterations in these ultradian oscillations, eight, modestly overweight, older men (65 +/- 5 years) and eight weight-matched young control subjects (25 +/- 4 years) were studied during 53 h of constant glucose infusion. Blood samples were collected every 20 min and insulin secretion rates were calculated by deconvolution. Ultradian oscillations of glucose and insulin secretion were evident in both groups. Pulse frequency was similar for glucose and insulin secretion, and was not affected by age. The absolute amplitude of the glucose oscillations was similar in both groups but their relative amplitude was slightly dampened in the older adults. Both the absolute and the relative amplitudes of insulin secretory oscillations were markedly reduced in the older subjects. The normal linear increase in the amplitude of insulin oscillations occurring with increasing amplitudes of glucose oscillations was still present in the older adults but analysis of covariance indicated that the slope was significantly lower than in the young control subjects (p < 0.0005), reflecting a decreased responsiveness of the beta cell to glucose changes. The temporal concordance between insulin and glucose oscillations, as estimated by pulse concomitancy and cross-correlation, was also lower in older subjects. The similarities between the alterations in the ultradian oscillations of insulin secretion and glucose in older healthy adults and those occurring in diabetic patients suggest that an impairment of beta-cell function may play a primary role in the deterioration of glucose tolerance in aging. [less ▲]

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See detailTransition probabilities for forbidden lines of Fe III
Quinet, Pascal ULg

in Astronomy and Astrophysics. Supplement Series (1996), 116

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See detailLa dérivée schwarzienne
Bair, Jacques ULg; Haesbroeck, Gentiane ULg

in Mathématique et Pédagogie (1996), 108

Dans cette note est introduit le concept de dérivée schwarzienne pour une fonction réelle univariée. Diverses propriétés et applications sont également proposées.

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See detailActivités sportives et système immunitaire
PIRNAY, Freddy ULg; Bury, Thierry ULg

in Médecine et Hygiène (1996), 54

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See detailInterregional correlation of cerebral glucose metabolism in unmedicated schizophrenia
Biver, Françoise; Goldman, Serge; De Maertelaer, Viviane et al

in European Neuropsychopharmacology (1996), 6(2), 141-147

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in ... [more ▼]

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in 15 unmedicated schizophrenic patients and 15 healthy subjects. We analyzed correlations between glucose metabolism data of multiple brain regions using factorial analysis and correlation coefficient comparisons. Absolute regional intercorrelations in schizophrenic brains were found to be significantly stronger than in controls, in relationship to the greater variability of metabolic rates in schizophrenic patients. Variability of normalized metabolic rates and regional intercorrelations were not significantly different between schizophrenic patients and control subjects. We conclude that a global metabolic factor accounts for the variability of metabolic data in untreated schizophrenia. [less ▲]

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See detailBenard-Marangoni instability in rigid rectangular containers
Dauby, Pierre ULg; Lebon, Georgy ULg

in Journal of Fluid Mechanics (1996), 329

Not Available

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See detailLe diabete non insulinodependant: de la physiopathologie au traitement.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(7-9), 395-402402-5

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important ... [more ▼]

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important public health problem. This polygenic disease is often expressed late in life and its evolution is accelerated by environmental factors leading to obesity. It combines defects in both insulin secretion and insulin action, and such defects are present in various proportions according to the type of patient and the stage of the disease. Diet and physical activity recommendations are the basis of the treatment. Current pharmacological approaches aim at improving insulin secretion and/or insulin cellular action. After secondary failure to oral drugs, insulin therapy should be initiated, the patient becoming "insulin-requiring". A synergy should be searched in the combination of various therapeutic modalities in order to improve the glycaemic control. [less ▲]

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See detailModelling the competition between two phytoplanktonic species
Elkafazi, Abderahman; Djenidi, Salim ULg; Nihoul, Jacques ULg

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailCes histoires que l'on construit et que l'on se raconte...
Guillaume, Jean-François ULg

in Cahiers Internationaux de Sociologie (1996), 100

A partir des réflexions de Paul Ricoeur sur la temporalité et la narrativité, l'A. envisage les processus discursifs de construction identitaire chez les jeunes gens en fin de scolarité obligatoire. L ... [more ▼]

A partir des réflexions de Paul Ricoeur sur la temporalité et la narrativité, l'A. envisage les processus discursifs de construction identitaire chez les jeunes gens en fin de scolarité obligatoire. L'identité en construction est appréhendée à travers le récit qu'ils donnent de leurs projets d'avenir et de leur histoire familiale. La présentation de soi, perçue dans cette double dimension, est soumise à un ensemble de schèmes ou de modèles narratifs culturellement ancrés et socialement véhiculés. Elle prend forme et se constitue en une totalité cohérente et intelligible par une « mise en intrigue » de la diversité des péripéties vécues ou imaginées. [less ▲]

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See detailTribology in Aerospace Propulsion Mechanisms
Bozet, Jean-Luc ULg

in Space Scientific Research in Belgium, vol. IV : Space Technology (1996), 4

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