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See detailDissections artérielles et manipulations cervicales
DELVAUX, Valérie ULg; GERARD, Pascale ULg; DE PASQUA, Victor ULg et al

in Revue Neurologique (1999), 155(Supp 1), 160

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See detailLes conséquences de l'infection des bovins par le virus de la rhinotrachéite infectieuse bovine
Thiry, Etienne ULg; Lemaire, Mylène; Schynts, Frédéric et al

in Point Vétérinaire (1999), 30

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See detailImpairment of neuromuscular transmission in a subgroup of migraine patients
Ambrosini, Anna; MAERTENS DE NOORDHOUT, Alain ULg; Alagona, Giovanna et al

in Neuroscience Letters (1999), 276(3), 201-3

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura ... [more ▼]

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholine release. Using single fiber EMG recordings we were able to demonstrate subclinical abnormalities of neuromuscular transmission in a subgroup of patients suffering from migraine with aura. This could be related to genetic abnormalities of P/Q Ca2+ channels in certain patients suffering from migraine with aura, which needs to be explored by proper genetic analyses. [less ▲]

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See detailGalectin-1 Expression in Prostate Tumor-Associated Capillary Endothelial Cells Is Increased by Prostate Carcinoma Cells and Modulates Heterotypic Cell-Cell Adhesion
Clausse, Nathalie; van den Brule, Frédéric; Waltregny, David ULg et al

in Angiogenesis (1999), 3(4), 317-25

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host ... [more ▼]

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host immune cells. Galectin-1, a soluble human lectin, is involved in numerous biological functions including cell-cell and cell-substrate interactions. In addition, galectin-1 is able to induce apoptosis of activated T-lymphocytes. In this study, we have examined galectin-1 expression in capillaries associated to the carcinoma cells or present in the remote non-tumoral stroma of 100 human prostate carcinoma samples by immunoperoxidase staining. Galectin-1 was expressed by endothelial cells from capillaries infiltrating the tumor tissue in 64% (64/100) of the cases. On the contrary, endothelial cells in the adjacent non-tumoral stroma expressed galectin-1 in very few cases (7/100). Increased frequency of galectin-1-positive capillaries in the tumor-associated compared to the tumor-free areas was observed in 63% of the cases. This striking contrast led us to set up an in vitro model to test whether tumor cells could induce galectin-1 expression by endothelial cells. Incubation of human umbilical vein endothelial cells with conditioned media from PC-3 or DU 145 prostate carcinoma cells led to a significant increase of galectin-1 protein expression (+32.97% and 37.91% P < 0.01 and P < 0.05, respectively). PC-3 conditioned medium also induced increased adhesion values of PC-3 cells to the endothelial cells (53.4 +/- 4.7 vs. 38.5 +/- 3.5 after 30 min; 66.6 +/- 7.8 vs. 46.2 +/- 6.4 after 60 min). An anti-galectin-1 antiserum abolished this modulation, and recombinant galectin-1 also induced increased adhesion values in a dose-dependent fashion. This effect was specific as no such modulations were observed using normal lymphocytes instead of PC-3 cells. Preferential galectin-1 expression in the endothelial cells close to the cancer cells could provide these latter with increased abilities to interact with the endothelial cells as well as a defense against the host immune system. [less ▲]

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See detailQuantitative determination of haptoglobin (HAP) in human and bovine sera by capillary zone electrophoresis (CZE).
Pirlot, Alain ULg; Janssens, J.; Skinner, G. et al

in Veterinary research (1999), 30(5), 483-93

This study describes an original assay for serum haptoglobin determination by measuring the capacity of human haptoglobin (hHAP) and bovine haptoglobin (bHAP) to bind haemoglobin (Hb) as established by ... [more ▼]

This study describes an original assay for serum haptoglobin determination by measuring the capacity of human haptoglobin (hHAP) and bovine haptoglobin (bHAP) to bind haemoglobin (Hb) as established by capillary zone electrophoresis (CZE). This method involves the addition of Hb in excess to the serum and the separation of the HAP-Hb complexes from free haemoglobin by CZE. Protein migration was recorded at a wavelength of 415 nm which reveals Hb alone (free or bound), and the concentration of HAP was indirectly estimated by measuring bound Hb. Different CZE conditions and the peak migration time of Hb from various species (human, equine, bovine, canine) were investigated. The electrophoretic separation of free human Hb (hHb) in excess and the hHAP-hHb complex was fully achieved by CZE, allowing a quantitative determination of hHAP. However, bovine haemoglobin (bHb) bound to bHAP and free bHb were poorly separated under the same conditions. The best detachment between bHAP-Hb complexes and free Hb was only attained in the bovine sample by use of canine haemoglobin (cHb). CZE assays performed with cHb gave very close values to those of a classic photometric method which measured the peroxidase activity of the haptoglobin-cyanmethaemoglobin complexes (y = 1.0168x - 0.072; r2 = 0.97). CZE assay was fast (< 10 min), inexpensive, did not require the use of a specific antibody and was reproducible (coefficient of variation, CV 3.6%). [less ▲]

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See detailMécanismes de l'action hypnotique des agents anesthésiques
Bonhomme, Vincent ULg; Brichant, Jean-François ULg; Dewandre, Pierre-Yves ULg et al

in Praticien en Anesthésie Réanimation (Le) (1999), 3

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See detailContribution of the carbohydrate moiety to conformational stability of the carboxypeptidase Y high pressure study.
Dumoulin, Mireille ULg; Ueno, H.; Hayashi, R. et al

in European Journal of Biochemistry (1999), 262(2), 475-83

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the ... [more ▼]

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the catalytic activity and, the intrinsic and 8-anilino-1-naphthalene sulfonic acid binding fluorescences. Pressure-induced denaturation of carboxypeptidase Y is a process involving at least three transitions. Low pressures (below 150 MPa) induced slight conformational changes characterized by a slight decrease in the center of the spectral mass of intrinsic fluorescence, whereas no changes in 8-anilino-1-naphthalene sulfonic acid binding fluorescence were observed and 80% of the catalytic activity remained. Higher pressure (150-500 MPa) induced further conformational changes, characterized by a large decrease in the center of the spectral mass of intrinsic fluorescence, a large increase in the 8-anilino-1-naphthalene sulfonic acid binding fluorescence and the loss of all catalytic activity. Thus, this intermediate exhibited characteristics of molten globule-like state. A further increase, in pressure (above 550 MPa) induced transition from this first molten globule-like state to a second molten globule-like state. This two-stage denaturation process can be explained by assuming the existence of two independent structural domains in the carboxypeptidase molecule. A similar three-transition process was found for unglycosylated carboxypeptidase Y, but, the first two transitions clearly occurred at lower pressures than those for glycosylated carboxypeptidase Y. These findings indicate that the carbohydrate moiety protects carboxypeptidase Y against pressure-induced denaturation. The origin of the protective effects is discussed based on the known crystallographic structure of CPY. [less ▲]

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See detailMimicry and the judgment of emotional facial expression
Blairy, Sylvie ULg; Herrera, P; Hess, U

in Journal of Nonverbal Behavior (1999), 23(1), 5-41

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See detailDe l'intelligence à la personnalité: une analyse sociocognitive
Garcet, Serge ULg

in Revue Scientifique de l'AIGS (1999), 2

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See detailPunch Press Vibration Isolation: a Case History
Golinval, Jean-Claude ULg; Géradin, Michel ULg

in European Journal of Mechanical and Environmental Engineering (1999), 44(3), 141-145

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See detailPrise en charge diagnostique d'un amas de calcifications atypiques par la méthode MIBB
LIFRANGE, Eric ULg; BOURDOUX, B; DESREUX, Joëlle ULg et al

in Gunaïkeia (1999), 4

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See detailL'accès à la communication scientifique, un concept global
Pochet, Bernard ULg

in Documentation & Bibliothèques (1999), 45(3), 101-105

After the observation of information retrieval behaviors and the use and management of scholarly information it is obvious that we need for information literacy courses. After several years of practice ... [more ▼]

After the observation of information retrieval behaviors and the use and management of scholarly information it is obvious that we need for information literacy courses. After several years of practice, research and reflexion quickly described, and an overview of the literature the author suggest to think scientific communication as a whole and to consider the student and researcher both as a user and as author. The article defines this whole conception of scientific communication and gives as an example a information literacy course based on this principle, making the bet that learning of scientific culture and the world of science communication must be part of the same draft training. [less ▲]

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See detailThe structure of two fengycins from Bacillus subtilis S499.
Schneider, J.; Taraz, K.; Budzikiewicz, H. et al

in Zeitschrift für Naturforschung. C, Journal of Biosciences (1999), 54(11), 859-66

The structures of the two fengycins, lipopeptides from Bacillus subtilis, were elucidated by spectroscopic methods and chemical degradation. They show a close structural relationship to the plipastatins ... [more ▼]

The structures of the two fengycins, lipopeptides from Bacillus subtilis, were elucidated by spectroscopic methods and chemical degradation. They show a close structural relationship to the plipastatins from Bacillus cereus differing only in the stereochemistry of the Tyr residues. [less ▲]

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See detailIn vitro stimulation of human gingival epithelial cell attachment to dentin by surface conditioning.
Van Heusden, Alain ULg; Goffinet, Gerhard ULg; Zahedi, Sharham et al

in Journal of Periodontology (1999), 70(6), 594-603

BACKGROUND: Chemical root conditioning is widely used to improve the outcome of regenerative periodontal therapies by favoring the attachment of the regenerated periodontal structures. Although the effect ... [more ▼]

BACKGROUND: Chemical root conditioning is widely used to improve the outcome of regenerative periodontal therapies by favoring the attachment of the regenerated periodontal structures. Although the effect of root conditioning on periodontal mesenchymal cells is well documented, very little is known about its potential effect on the re-formation of the junctional epithelium, a crucial event for the protection of the wound. The goal of the present study was to test in vitro the consequences of dentin conditioning with citric acid or minocycline on the attachment kinetics and morphology of human gingival keratinocytes (HGK). METHODS: The attachment kinetics of HGK to samples of powdered human dentin (particle size 44 to 76 microm) were examined by use of 3H-labeled cells. The morphology of attached epithelial cells was then determined by scanning electron microscopy (SEM). RESULTS: When the initial adhesion kinetics of cells on untreated dentin were tested, the percentage of attached HGK proved to be dependent on the number of plated cells and the time of incubation (from 0 to 12 hours). Conditioning the dentin by 3% citric acid or by minocycline-HCl (at 0.01, 0.1, or 2.5%) significantly increased (P <0.005) keratinocyte attachment beyond 6 hours, without notable differences between the 2 substances at any concentration. The attachment kinetics of HGK preincubated for 24 hours by 10 microg/ml minocyline-HCl on untreated dentin was found to be similar to that observed for non-preincubated cells. These results are in agreement with the SEM observations: indeed, the surface conditioning of dentin significantly modified the morphology of attached HGK, whereas the preincubation of these cells with minocyline-HCl did not. CONCLUSIONS: These results suggest that minocycline-HCl does not exert a direct effect on human gingival epithelial cells. In contrast, conditioning the dentin by citric acid or by minocycline stimulates the attachment of HGK, which could lead to a rapid periodontal healing by favoring the re-formation of a junctional epithelium. [less ▲]

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See detailComputer Simulation Of Surfactin Conformation At A Hydrophobic/Hydrophilic Interface
Gallet, X.; Deleu, Magali ULg; Razafindralambo, Hary ULg et al

in Langmuir (1999), 15(7), 2409-13

Using a molecular modeling method, different conformations of surfactin at a hydrophobic/hydrophilic interface are established. Two conformations of the peptide ring (S1 and S2) provided by NMR ... [more ▼]

Using a molecular modeling method, different conformations of surfactin at a hydrophobic/hydrophilic interface are established. Two conformations of the peptide ring (S1 and S2) provided by NMR experiments built with three different aliphatic chains in folded or extended configurations were studied. For the structures including the S2 peptide ring conformation, the theoretical interfacial molecular area corresponds to the experimental limiting area A0 value obtained with a Langmuir film balance. The peptide ring is positioned in the plane of the interface with the two acidic chains close to each other and protruding in the aqueous phase, and the β-hydroxy fatty acid chain, folded to interact mainly with the Leu2 side chain and also with the Val4 side chain. This design has the largest calculated molecular area and would correspond to the most stable amphipathic structure representing the surfactin experimental behavior in weak compression. [less ▲]

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See detailDelayed massive immune hemolysis mediated by minor ABO incompatibility after allogeneic peripheral blood progenitor cell transplantation.
Salmon, Jean ULg; Michaux, S.; Hermanne, J. P. et al

in Transfusion (1999), 39(8), 824-7

BACKGROUND: Bone marrow transplantation with minor ABO incompatibility may be followed by moderate delayed hemolysis of the recipient's red cells by donor-derived ABO antibodies. This reaction may be more ... [more ▼]

BACKGROUND: Bone marrow transplantation with minor ABO incompatibility may be followed by moderate delayed hemolysis of the recipient's red cells by donor-derived ABO antibodies. This reaction may be more severe after transplantation of peripheral blood progenitor cells (PBPCs). CASE REPORT: A 16-year-old boy underwent an allogeneic PBPC transplant from his HLA-mismatched mother as treatment for acute myeloblastic leukemia that had proved resistant to induction chemotherapy. Transfusion of the unmanipulated PBPCs proceeded without any complication, despite the difference in ABO blood group (donor, O Rh-positive; recipient, A Rh-positive). On Day 7, a rapid drop in hemoglobin to 4 g per dL was observed, which was attributed to a massive hemolysis. All the recipient's group A red cells were destroyed within 36 hours. This delayed and rapidly progressive hemolytic anemia was not associated with the transfusion of the donor's plasma. Rather, the anti-A titer increased in parallel with marrow recovery, which suggested an active synthesis of these antibodies by immunocompetent cells from the donor against the recipient's red cells. The mother's anti-A titer was retrospectively found to be 2048. Her unusually high titer is probably due to prior sensitization during pregnancies. On Day 12, the patient developed grade IV graft-versus-host disease, which proved resistant to all treatments instituted and led to his death on Day 35. CONCLUSION: PBPC transplantation with minor ABO incompatibility may be associated with significant risk of massive delayed hemolysis. [less ▲]

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See detailPrognostic Factors in Urothelial Renal Pelvis and Ureter Tumours: a Multicentre Rare Cancer Network Study
Ozsahin, M; Zouhair, A; Villa, S et al

in European Journal of Cancer & Clinical Oncology (1999), 35/5

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter ... [more ▼]

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n=71), nephroureterectomy and lymphadenectomy (n=20), nephroureterectomy and partial bladder resection or transurethral resection (n=20), nephrectomy (n=10), and ureterectomy (n=5). Sixty-one per cent (n=77) of the tumours were located in the renal pelvis, and 21% (n=27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis. [less ▲]

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See detailL'université, entre pouvoirs et contre-pouvoir
Bachelet, Jean-François ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1999), 85-86-87(1999), 51-60

Réflexion sur la signification du processus de transformation de l'institution universitaire.

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See detailCorrelative and experimental investigations on the segregation of aquatic bryophytes as a function of water chemistry in the Walloon hydrographic network
Vanderpoorten, Alain ULg

in Lejeunia, Revue de Botanique (1999), (No. 159), 1-17

The aquatic bryophyte assemblages of the Walloon hydrographic network [Belgium] are significantly correlated to the gradients of water pollution. Experimental cultures showed that Fe and benzopyrene ... [more ▼]

The aquatic bryophyte assemblages of the Walloon hydrographic network [Belgium] are significantly correlated to the gradients of water pollution. Experimental cultures showed that Fe and benzopyrene, which were among the most significantly correlated factors with the changes in the aquatic bryophyte assemblages, did not inhibit the growth of the investigated taxa, at concentrations much higher than those measured in rivers. The correlation of these factors with the floristic assemblages is thus an artefact due to the inter-correlation between the variables. The concentrations of N-NH4+ inducing a growth inhibition varied between 10 mg/litre in a population of Amblystegium tenax and 500 mg/litre in A. riparium. The lethal concentrations are similar to the current annual mean concentrations of this factor in the polluted rivers of this network. This factor is thus directly implied in the segregation of these species along a gradient of water pollution. The populations of A. tenax coming from a heavily polluted area exhibited a tolerance to N-NH4+ five to ten times higher than the populations coming from unpolluted rivers. These result suggest that ecotypes may exist in this species [less ▲]

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See detailMedicaments et grossesse.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(5), 409-14

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the ... [more ▼]

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the public as well as among medical doctors. However, the complexity of the problem, the lack of robust scientific data and the emotional context characterizing this period make the prescription of medications to a pregnant woman a difficult task for every people involved in health care, the pharmacist, the general practitioner and even the gynaecologist. [less ▲]

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See detailAPH-1, a POU homeobox gene expressed in the salt gland of the crustacean Artemia franciscana
Chavez, Marcela; Landry, Claire; Loret, Suzanne et al

in Mechanisms of Development (1999), 87(1-2), 207-12

We characterized the first POU-homeoprotein in a crustacean (designated APH-1 for Artemia POU-Homeoprotein, EMBL Y15070). The amino acid sequence of the APH-1 POU-domain is identical, except for two ... [more ▼]

We characterized the first POU-homeoprotein in a crustacean (designated APH-1 for Artemia POU-Homeoprotein, EMBL Y15070). The amino acid sequence of the APH-1 POU-domain is identical, except for two residues, to that of the two class III POU proteins Cf1-a (Drosophila) and POU-M1 (Bombyx mori). Southern blot analysis suggests that crustaceans have only one class III POU gene. RT-PCR and whole-mount in situ hybridization show that APH-1 mRNA is present in larvae specifically in the salt gland, an organ which is involved in osmoregulation, and disappears in the adult. [less ▲]

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See detailDual time point fluorine-18 fluorodeoxyglucose positron emission tomography: a potential method to differentiate malignancy from inflammation and normal tissue in the head and neck.
Hustinx, Roland ULg; Smith, R. J.; Benard, F. et al

in European Journal of Nuclear Medicine (1999), 26(10), 1345-8

Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) studies imaging FDG PET imaging is used to detect and stage head and neck cancers. However, the variable physiologic uptake of FDG ... [more ▼]

Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) studies imaging FDG PET imaging is used to detect and stage head and neck cancers. However, the variable physiologic uptake of FDG in different normal structures as well as at inflammatory sites may either obscure a tumor focus or be falsely interpreted to represent tumor activity. Twenty-one patients (9 men, 12 women, median age 59) were scanned serially at two time points, one at 70 min (range 47-112) and the second at 98 min (77-142) after the intravenous injection of 4.3 MBq/kg of FDG. The mean interval between emission scans was 28 min (13-49). Transmission scans were performed and regions of interest (ROIs) were overlayed on the fully corrected images. Standardiued uptake values (SUVs) were generated for the cerebellum, tongue, larynx, every lesion, and a matched contralateral site. Follow-up and pathologic studies revealed 18 squamous cell carcinomas and nine inflammatory or infectious lesions. Tumor SUVs were 4.0+/-1.6 (mean +/- SD) for the first scan and 4. 5+/-2.2 for the second scan. Contralateral SUVs were 1.2+/-0.5 and 1. 1+/-0.5 for the two scans. Tumor SUVs increased by 12%+/-12% as compared with a 5%+/-17% decrease for contralateral sites (P<0.05). SUVs for inflammatory sites (2.0+/-0.7 and 2.0+/-0.9), cerebellum (4. 2+/-1.3 and 4.3+/-1.4), tongue (1.8+/-0.4 and 1.9+/-0.5) and larynx (1.5+/-0.6 and 1.5+/-0.6) remained constant over time (+0.6%, +2.8%, +1.4%, and -2.4%; P<0.05 when compared with tumor SUV changes). The ratio tumor/contralateral SUV increased by 23%+/-29% over time while this ratio for inflamed sites increased by only 5%+/-15% (P=0.07). The time interval between scans correlated with increase in SUV for tumors (r=0.55, P<0.05) but not for any of the other ROIs. Separation was superior when studies were performed more than 30 min apart (P<0.05). These preliminary data suggest that dual time point imaging compatible with a clinical study protocol is helpful in differentiating malignant lesions from inflammation and normal tissues, especially when separated by a sufficient time interval. [less ▲]

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See detailConsensus statement on the treatment of septic shock
Spapen, H.; Damas, Pierre ULg; D'Orio, Vincenzo ULg et al

in Acta Clinica Belgica (1999), 54(5), 256-262

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See detailDeep circulation changes in the Labrador sea since the last glacial maximum: New constraints from Sm-Nd data on sediments
Fagel, Nathalie ULg; Innocent, C.; Stevenson, R. K. et al

in Paleoceanography (1999), 14(6), 777-788

Sm-Nd concentrations and Nd isotopes were investigated in the fine fraction of two Labrador Sea cores to reconstruct the deep circulation patterns through changes in sedimentary supply since the last ... [more ▼]

Sm-Nd concentrations and Nd isotopes were investigated in the fine fraction of two Labrador Sea cores to reconstruct the deep circulation patterns through changes in sedimentary supply since the last glacial stage. Three sources are involved: the North American Shield, Palaeozoic rocks from northeastern Greenland, and mid-Atlantic volcanism. The variable input of these sources provides constraints on the relative sedimentary supply, in conjunction with inception of deep currents. During the last glacial stage a persistent but sluggish current occurred inside the Labrador Basin. An increasing discharge of volcanic material driven by the North East Atlantic Deep Water is documented since 14.3 kyr, signaling the setup of a modern-like deep circulation pattern throughout the Labrador, Irminger, and Iceland basins. During the last deglacial stage the isotopic record was punctually influenced by erosion processes related mainly to ice-sheet instabilities, especially 11.4, 10.2, and 9.2 kyr ago. [less ▲]

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See detailImproving The Catabolic Functions Of Desiccation-Tolerant Soil Bacteria
Weekers, F.; Jacques, Philippe ULg; Springael, D. et al

in Applied Biochemistry and Biotechnology (1999), 77-9

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See detailMagnetic resonance arthrography of cubital joint in dogs affected with fragmented medial coronoid process
Snaps, Frédéric ULg; Park, R. D.; Saunders, J. et al

in American Journal of Veterinary Research (1999), 20

Objective-To evaluate efficacy of intra-articular injection of gadolinium tetra- azacyclododecane tetraacetic acid (gadolinium-DOTA) for delineating fragmented medial coronoid processes (FMCP) and lesions ... [more ▼]

Objective-To evaluate efficacy of intra-articular injection of gadolinium tetra- azacyclododecane tetraacetic acid (gadolinium-DOTA) for delineating fragmented medial coronoid processes (FMCP) and lesions on the medial aspect of the humeral condyle (MAHC). Sample Population-14 cubital joints in 9 dogs. Procedure-Magnetic resonance imaging (MRI) was performed with and without intra-articular injection of a solution of 2 mmol of gadolinium-DOTA/L. Arthrographic images obtained after injection of contrast medium were compared with those obtained without contrast medium. Evidence of contrast medium around or in the medial coronoid process and infiltration of contrast medium in subchondral bone lesions was recorded, Twenty-four hours after imaging, arthroscopy was performed, and lesions detected were correlated with results of MRI. Results-An abnormal coronoid process was diagnosed in 13 of 14 joints. A fragmented process (free) was seen in 7 of 14 joints; nondisplaced mineralized medial tin situ) coronoid processes were evident in 4 joints; and nondisplaced unmineralized medial coronoid processes were evident in 2 joints. Lesions on the MAHC were diagnosed in 4 of 12 joints. In 5 joints, a hyperintense signal resulted from contrast medium that infiltrated between the fragmented process and ulna. In 2 joints, contrast medium did not infiltrate completely around the process and was stopped by an isointense structure tie, abnormal cartilage). Subchondral bone lesions were enhanced by use of contrast medium. Conclusion and Clinical Relevance-Use of arthrography enabled us to identify FMCP easily, but did not provide important additional information about changes on the medial coronoid process, compared with MRI performed without contrast medium. [less ▲]

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See detailLe sémioticien
Durand, Pascal ULg

in Art&Fact (1999), (18), 81-82

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See detailShort-term toxicity of various pharmacological agents on the in vitro nitrification process in a simple closed aquatic system
Nimenya, H.; Delaunois, Annie; La Duong, Duc ULg et al

in Alternatives to Laboratory Animals (1999), 27

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures ... [more ▼]

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures of nitrifying bacteria. The purpose of this study was to quantify the inhibitory effects of 15 pharmacological agents, which are often used as therapeutic agents in ichthyopathology, on ammonia removal and nitrate production in a simple closed aquatic system. The experiments were conducted in polyethylene bags containing activated biofilters and synthetic water solutions, held in a water bath. Ammonia was added to initiate the nitrification process, and graded concentrations of various pharmacological agents were added. The effects of the pharmacological agents on in vitro nitrification were assessed by monitoring ammonia and nitrate concentrations compared to controls with no added agents, for 24 hours. Graded concentrations of ampicillin (Albipen(R)), chloramine T, enrofloxacin (Baytril(R)), erythromycin, levamisole, methylene blue and polymyxin B induced dose-dependent inhibitions of ammonia removal and nitrate production. The corresponding linear regression curves showed high correlation coefficients and were highly significant (p < 0.05). The addition of chloramphenicol, copper (II) sulphate, kanamycin disulphate, malachite green, neomycin sulphate, potassium penicillin G, tetracycline and a mixture of trimethoprim and sulphadoxin (Duoprim(TM)) had no significant effects on the nitrification process. A significant dose-related inhibition of nitrate production, but not of ammonia oxidation, was observed with enrofloxacin. The significant correlation (r = 0.940; p < 0.001) between the degrees of inhibition of ammonia oxidation and nitrate production for the various inhibitory pharmacological agents has also been calculated, with a view to validating this method. The data presented suggest that separate tank facilities for hospitalisation or quarantine are necessary when treating diseased fish with ampicillin, enrofloxacin, chloramine T, erythromycin, levamisole, methylene blue or polymyxin B, in order to avoid ammonia poisoning. [less ▲]

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See detailLes aliments industriels chez les carnivores domestiques : I. Caractéristiques et développement du secteur des aliments "Premium"
Derua, N.; Istasse, Louis ULg; Diez, Marianne ULg

in Annales de Médecine Vétérinaire (1999), 143

The petfood industry is developping considerably over the last years. Nowadays commercial pet foods are used to a larger extent than home made diets. New types of pet foods as premium or super-premium ... [more ▼]

The petfood industry is developping considerably over the last years. Nowadays commercial pet foods are used to a larger extent than home made diets. New types of pet foods as premium or super-premium appeared in order to meet more closely the requirements of dogs and cats and the wishes of their owners. The present paper aims to describe the different forms of pet foods along with their main characteristics. The major trends of petfood market, the concept of premium foods and their characteristics will also be presented. Finally, palatability tests and digestibility trials will be explained. [less ▲]

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See detailShiga/Verocytotoxins and Shiga/Verotoxigenic Escherichia coli in Animals
Mainil, Jacques ULg

in Veterinary Research (1999), 30(2-3, Mar-Jun), 235-257

Vero/Shiga toxins (VT/Stx) have an A-B structure: the A subunit carries the enzymatic activity and the B subunit binds the toxin to the membrane receptor (Gb3 or Gb4). The VT/Stx inhibit protein synthesis ... [more ▼]

Vero/Shiga toxins (VT/Stx) have an A-B structure: the A subunit carries the enzymatic activity and the B subunit binds the toxin to the membrane receptor (Gb3 or Gb4). The VT/Stx inhibit protein synthesis in the target eucaryotic cells, mainly the endothelial cells of blood vessels. The VT/Stx are subdivided into two families. VT1/Stx1 is a homogeneous family of toxins identical to the Stx of Shigella dysenteriae. VT2/Stx2 is a more heterogeneous family of toxins more distantly related to this Stx toxin. The VT2/Stx2 variants can be distinguished by the polymerase chain reaction (PCR) and/or the reaction with monoclonal antibodies. The VT/Stx-producing Escherichia coli are also subdivided into two main groups on the basis of the presence or absence of additional properties: the enterohaemorrhagic E. coli (EHEC) induce the formation of attaching/effacing lesions and carry a 60 MD plasmid encoding a specific haemolysin (the enterohaemolysin); the vero/shiga-toxigenic E. coli (VTEC/STEC) do not show these properties. The EHEC are isolated from humans and ruminants, especially young calves. They are associated with haemorrhagic enterocolitis and its sequelae in humans, the haemolytic-uraemic syndrome (HUS). The VT/Stx play a role in the occurrence of blood in the faeces and in the HUS by their action on the endothelial cells of blood vessels in the intestinal submucosa and in the renal glomeruli, after resorption through the intestinal walls. The VTEC/STEC are isolated from piglets, calves and humans. In recently weaned piglets, they cause the oedema disease, an enterotoxaemia characterized by subcutaneous, mesenteric and cerebral oedemas, with nervous disorders as main clinical signs. The oedema disease is the consequence of the action of the VT/Stx on the endothelial cells of blood vessels in various organs. In calves and humans, the role in disease of VTEC/STEC is controversial, but they could be associated with some cases of diarrhoea and HUS. The case of the O157:H7 EHEC which are present in healthy cattle of various ages, but are highly virulent for humans is of special interest. The potential zoonotic aspect of VT/Stx-producing E. coli infections in animals is detailed chapter by chapter. Prophylaxis of these infections by vaccination is the subject of the discussion on the future of the research studies on these pathogenic bacteria. [less ▲]

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See detailBibliographie concernant la loi de protection des malades mentaux
Boxho, Philippe ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1999), 21

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See detailPit-1 mediates cell-specific and cAMP-induced transcription of the tilapia GH gene
Sekkali, B.; Belayew, A.; Bortolussi, M. et al

in Molecular & Cellular Endocrinology (1999), 152(1-2), 111-23

Expression of the tilapia growth hormone (tiGH) gene is pituitary-specific and controlled by intracellular cAMP levels. DNaseI protection experiments allowed us to identify four Pit-1 binding sites in the ... [more ▼]

Expression of the tilapia growth hormone (tiGH) gene is pituitary-specific and controlled by intracellular cAMP levels. DNaseI protection experiments allowed us to identify four Pit-1 binding sites in the tiGH - 465/ + 19 region. Deletion and mutagenesis analysis revealed that the - 131/+ 19 region, containing two Pit-1 sites, or four copies of the most proximal site tiGHF1 fused to the heterologous Tk promoter, confer high level expression in rat pituitary cells and direct transcription in non-pituitary cells only after expression of rat Pit-1. We show that a tilapia pituitary factor specifically binds to site tiGHF1 and obtained a partial cDNA sequence coding for tilapia Pit-1. The cAMP stimulation is mediated by the proximal (- 131/- 31) promoter region. It is Pit-1-dependent and requires the tiGHF1 site. In addition, four copies of this site confer cAMP inducibility to the Tk promoter in GC cells. [less ▲]

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See detailLes aliments industriels chez les carnivores domestiques : II. Choix des ingrédients et application aux aliments "Premium"
Derua, N.; Istasse, Louis ULg; Diez, Marianne ULg

in Annales de Médecine Vétérinaire (1999), 143

Over the last 10 years the number of premium foods is increasing in the petfood industry for companion animals. It is often difficult for the vets in practice to compare different premium foods. The ... [more ▼]

Over the last 10 years the number of premium foods is increasing in the petfood industry for companion animals. It is often difficult for the vets in practice to compare different premium foods. The ingredients sources used in diet formulation remain a criterion to indirectly evaluate the quality. A judicious choice of feedstuffs directly influences palatability and digestibility of each diet. The present paper aims to describe the different nutrient sources used in the premium foods industry. Each nutrient and its sources are presented separately starting by protein, fat and carbohydrates and ending with vitamins and minerals. Labelling according to the offical recommandations is also reported. [less ▲]

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See detailIn vitro root cultures of Panax ginseng and P-quinquefolium
Kevers, Claire ULg; Jacques, Philippe ULg; Thonart, Philippe ULg et al

in Plant Growth Regulation (1999), 27(3), 173-178

The paper describes a procedure for the initiation, subculture and continued proliferation of adventitious roots of Panax ginseng and Panax quinquefolium, which resemble hairy roots. The technique took ... [more ▼]

The paper describes a procedure for the initiation, subculture and continued proliferation of adventitious roots of Panax ginseng and Panax quinquefolium, which resemble hairy roots. The technique took advantage of the high powerful activity of a new synthetic auxin: benzo[b]selenienyl acetic acid (BSAA). Such initiation from root explants was dependent upon the season, the type and concentration of auxin. The hairy-like roots of ginseng could be subcultured by transfer every 4 weeks to fresh liquid medium either in agitated Erlenmeyer flasks or in bioreactors. Optimal conditions for a continued multiplication (up to 14 per month) were determined. The only practical problem was the limitation of the fresh mass as inoculum: the multiplication rate decreased with the increased quantity of roots. It is postulated that a root growth inhibiting substance was released into the media by the proliferating ginseng hairy roots. [less ▲]

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See detailAn imprinted QTL with major effect on muscle mass and fat deposition maps to the IgfII locus in pigs
Nezer, C.; Moreau, L.; Brouwers, B. et al

in Nature Genetics (1999), 21

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See detailAbsces mammaire et toxemie gravidique revelateurs d'une tuberculose multiresistante.
GACH, Olivier ULg; CORHAY, Jean-Louis ULg; Lousberg, Laurent ULg et al

in Revue des Maladies Respiratoires (1999), 16(5), 842-5

We report here the case of a 33-year-old woman admitted in hospital for eclampsia. An infectious course led to the diagnosis of tuberculosis breast abscess with laryngitis and tuberculous bilateral ... [more ▼]

We report here the case of a 33-year-old woman admitted in hospital for eclampsia. An infectious course led to the diagnosis of tuberculosis breast abscess with laryngitis and tuberculous bilateral excavated bronchopneumonia. The isolated strain demonstrated resistance to the principals antituberculous agents. However outcome was favorable after cesarean and treatment adapted to sensitivity studies. [less ▲]

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See detailHeavy metals, organochlorines and polycyclic aromatic hydrocarbons in sperm whales stranded in Southern North sea during the 1994/1995 winter,
Hoolsbeek, L.; Joiris, C. R.; Debacker, Virginie ULg et al

in Marine Pollution Bulletin (1999), 38

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See detailThe Locus for Enterocyte Effacement (Lee) of Enteropathogenic Escherichia Coli (Epec) from Dogs and Cats
Goffaux, F.; China, B.; Janssen, L. et al

in Advances in Experimental Medicine and Biology (1999), 473

Enteropathogenic Escherichia coli (EPEC) produce attaching and effacing lesions. The genes responsible for this lesion are clustered on the chromosome forming a 35.5 kilobase pathogenesis island called ... [more ▼]

Enteropathogenic Escherichia coli (EPEC) produce attaching and effacing lesions. The genes responsible for this lesion are clustered on the chromosome forming a 35.5 kilobase pathogenesis island called LEE. The LEE was identified, characterized and completely sequenced from the human EPEC strain E2348/69. The LEE carries genes coding for: a type III secretion system (genes esc and sep), the translocated intimin receptor (gene tir), the outer membrane protein intimin (gene eae) and the E. coli secreted proteins EspA, EspB, and EspD (genes esp). In addition to man and farm animals, EPEC are also isolated from dogs and cats. We studied structurally and functionally the LEE of dog and cat EPEC. First, we used four probes scattered along the LEE to identify the presence of a LEE in canine and feline EPEC isolates. Second, by PCR, we checked the presence of genes homologous to eae, sep, esp, and tir genes in these strains. Third, since the four types of eae and tir genes were described, we developed a multiplex PCR in order to determine the type of eae and tir genes present in each strain. Fourth, we determined by PCR the site of the LEE insertion on the chromosome. Fifth, we tested several of the canine EPEC in their capacity to induce attaching and effacing lesions in the rabbit intestinal loop assay. We can conclude from this study: first, that the a LEE-like structure is present in all tested strains and that it contains genes homologous to esp, sep, tir, and eae genes; second, that there is some preferential associations between the type of eae gene and the type of tir gene present in a strain; third, that the majority of the tested strains contained a LEE located elsewhere on the chromosome in comparison to the human EPEC strain E2348/69; and fourth that dog EPEC were able to induce attaching and effacing lesions in rabbit ileal loop assay. [less ▲]

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See detailLa mortalité embryonnaire. 2. Implications hormonales
Hanzen, Christian ULg; Lourtie, O.; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailCan the standardized uptake value characterize primary brain tumors on FDG-PET?
Hustinx, Roland ULg; Smith, R. J.; Benard, F. et al

in European Journal of Nuclear Medicine (1999), 26(11), 1501-9

The aim of this study was to evaluate the usefulness of measuring the standardized uptake value (SUV) in primary brain tumors on fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET ... [more ▼]

The aim of this study was to evaluate the usefulness of measuring the standardized uptake value (SUV) in primary brain tumors on fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scans. Two groups of patients were studied. Whole-brain glucose cerebral metabolic rates (wCMRs) and SUVs were obtained in 20 normal subjects. Twenty-seven patients with histology-proven malignant primary CNS tumors (high-grade gliomas n=22, primitive neuroectodermal tumors n=3, ependymomas n=2) were also studied. The degree of FDG uptake was assessed by visual inspection and thereafter regions of interest were placed over the lesion, the contralateral cortex and white matter and the whole brain. Average (avg) and maximum (max) pixel values were determined in each site. Based on these measurements, SUV, tumor to cortex (T/C) and tumor to white matter (T/WM) activity ratios were calculated. There was no correlation between wCMRs (4.55+/-0.36 mg min(-1) 100 g(-1)) and wSUVs (5.41+/-0.43) in the normal subjects (r=0.18, P=0.45). In the second group, 17 lesions were described as definitely and seven as probably malignant. However, SUVs in these tumors and in the contralateral cortex were not significantly different. Although the SUVs were generally higher in the tumor than in the contralateral white matter, there was a significant overlap between the values. The range of the SUVs was wide: 2.54-11.8 for the tumors, 2.98-9.96 for the cortex and 1.87-6.76 for the white matter. SUVs in the normal cortex were negatively correlated with blood glucose level at the time of the injection. SUVs in the whole brain and in the cortex were lower in patients previously treated by irradiation, even months after completion of the treatment. No correlation was detectable between any of the SUVs and the age of the patients, tumor type, time post injection, use of dexamethasone, patient weight, dose injected and visual score. With cutoff levels of 1.5 for T max/WM and 0.6 for T max/C, the sensitivity of the activity ratios was 74% and 96% respectively. In conclusion, SUVs do not correlate with CMRs across subjects and appear to be of limited value in characterizing brain tumors. Visual assessment and measurement of the activity ratios currently remain the most reliable methods of analysis. [less ▲]

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See detailA critical compilation and extended analysis of the Ne IV spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1999), 7

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete ... [more ▼]

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete and consistent up-to-date tables of spectral lines and energy levels, particularly of the neon-ions spectra, notably reduces possibilities of interpretation of astrophysical and laboratory spectra. In the present paper, all optical spectral lines of Ne IV observed in 24 previous works have been systematised together with recent observations made by means of the beam-foil method at Liège University. As a result of our extended analysis of the whole set of available data, 35 new energy levels have been found and 90 newly classi ed spectral lines have been listed for the Ne IV spectrum, only a few of them having been reported previously. A complete table of observed and classi ed spectral lines has been built, and the list of optimised energy levels has been derived from it in a consistent way. A new, improved, ionisation potential of Ne IV has been deduced from the experimental data. [less ▲]

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See detailMolecular Evidence For An Andean Origin And A Secondary Gene Pool For The Lima Bean (Phaseolus Lunatus L..) Using Chloroplast Dna
Fofana, B.; Baudoin, Jean-Pierre ULg; Vekemans, X. et al

in Theoretical and Applied Genetics (1999), 98(2),

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See detailHypertension arterielle et diabete de type 2.
Scheen, André ULg; Estrella, F.; Weekers, Laurent ULg

in Revue Médicale de Liège (1999), 54(10), 789-95

Diabetes mellitus is frequently associated with arterial hypertension and the combination of both entities markedly increases the vascular risk. In type 2 diabetes, hypertension appears very early ... [more ▼]

Diabetes mellitus is frequently associated with arterial hypertension and the combination of both entities markedly increases the vascular risk. In type 2 diabetes, hypertension appears very early, especially in the presence of obesity, is part of the insulin resistance syndrome, and contributes to high cardiovascular morbidity and mortality rates in this population. Appropriate regulation of blood pressure is crucial in order to reduce not only microangiopathy (nephropathy and retinopathy) but also macroangiopathy (coronary heart disease and stroke) in hypertensive type 2 diabetic patients. Target blood pressure values have been decreased in recent years and should be < 130/85 mmHg, and may be even lower according to recent data. The optimal modalities of pharmacological treatment remain controversial, but obviously several medications are required to reach such objectives in most hypertensive patients with type 2 diabetes. [less ▲]

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See detailLe statut du texte littéraire dans les manuels belges d'aujourd'hui. Petite excursion dans un maquis
De Croix, Séverine ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1999), 45

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See detailA critical compilation and extended analysis of the Ne V spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1999), 7

Previous works devoted to the Ne V spectrum are very fragmentary and yield a rather controversial picture of this ion. A lot of unidentifi ed lines are still reported in these multiple studies. In the ... [more ▼]

Previous works devoted to the Ne V spectrum are very fragmentary and yield a rather controversial picture of this ion. A lot of unidentifi ed lines are still reported in these multiple studies. In the present paper, Hartree-Fock calculations and least-squares fi ts over the whole set of the available data (including the most recent ones) have been performed. As a result, a comprehensive view of the Ne V spectrum is presented. 10 new energy levels and 40 newly classi fied lines are proposed. An improved value of the ionisation potential of Ne V is also proposed. [less ▲]

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See detailAn Evolutive Software Environment for Teaching the Finite Element Method in Electromagnetism
Dular, Patrick ULg; Geuzaine, Christophe ULg; Genon, André ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1682--1685

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See detailÉtats de la prose contemporaine
Badir, Sémir ULg

in Prétexte (1999), 21/22

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See detailDo babies resemble their fathers more than their mothers ? : a failure to replicate Christenfeld and Hill
Brédart, Serge ULg; French, R.

in Evolution and Human Behavior : Official Journal of the Human Behavior and Evolution Society (1999), 20(3), 129-135

Contrary to Christenfeld

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See detailLignosulfonates: Novel promoting additives for plant tissue cultures
Kevers, Claire ULg; Soteras, G.; Baccou, J. C. et al

in In Vitro Cellular and Developmental Biology - Plant (1999), 35(5), 413-416

Lignosulfonates (LIGNs) are low-cost by-products from the paper industry and are already commercialized as fertilizers. Because earlier laboratory and glasshouse assays had shown a beneficial effect of ... [more ▼]

Lignosulfonates (LIGNs) are low-cost by-products from the paper industry and are already commercialized as fertilizers. Because earlier laboratory and glasshouse assays had shown a beneficial effect of LIGNs on rooting and general plant vigor, their incorporation in several plant tissue culture types was examined here. The present assays indicated that well-chosen concentrations of LIGNs, whether they were chelated with Ca or Fe, stimulated growth of a normal and an habituated sugarbeet callus, improved multiplication rate and vigor of a shoot-proliferating poplar cluster, and increased the rooting percentage of holly, ginseng, and poplar shoots. Complementing the exogenous rooting auxin with LIGNs enhanced the increases of endogenous levels of indoleacetic acid and its aspartate conjugate in the basal parts of poplar shoots at the rooting inductive phase. Although LIGNs exerted some effects in the absence of the growth regulators, they could not replace them. Their possible mode of action is discussed. [less ▲]

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See detailCarbon stocks and isotopic budgets of the terrestrial biosphere at mid-Holocene and last glacial maximum times
François, Louis ULg; Godderis, Y.; Warnant, Pierre ULg et al

in Chemical Geology (1999), 159(1-4), 163-189

The carbon fluxes, stocks and isotopic budgets of the land biosphere at mid-Holocene (6 ka BP) and last glacial maximum (21 ka BP) times are reconstructed with the CARbon Assimilation In the Biosphere ... [more ▼]

The carbon fluxes, stocks and isotopic budgets of the land biosphere at mid-Holocene (6 ka BP) and last glacial maximum (21 ka BP) times are reconstructed with the CARbon Assimilation In the Biosphere (CARATB) model forced with two different sets of climates simulated by the European Centre-HAMburg (ECHAM) and LMD general circulation models. It is found that the trends predicted on the basis of both sets of GCM climatic fields are generally consistent with each other, although substantial discrepancies in the magnitude of the changes may be observed. Actually, these discrepancies in the biospheric results associated with the use of different GCM climatic fields are usually smaller than the differences between biospheric runs performed while considering or neglecting the CO2 fertilization effect (which might, however, be overestimated by the model due to uncertainties concerning changes in nutrient availability). The calculated changes with respect to the present of the biosphere carbon stock range from - 132 to + 92 Gt C for the mid-Holocene and from -710 to +70 Gt C for the last glacial maximum. It is also shown that the relative contribution of the material synthesized by C-4 plants to the total biomass of vegetation, litter and soils was substantially larger at mid-Holocene and last glacial maximum times than today. This change in the relative importance of the C-3 and C-4 photosynthetic pathways induced changes in the C-13 fractionation of the land biosphere. These changes in the average biospheric fractionation resulting from the redistribution of C-3 and C-4 plants were partly compensated for by changes of opposite sign in the fractionation of C-3 plants due to the modification of the intercellular CO2 pressure within their leaves. With respect to present times, the combination of both processes reduced the C-13 discrimination (i.e., less negative fractionation) of the land biosphere by 0.03 to 0.32 parts per thousand during the mid-Holocene and by 0.30 to 1.86 parts per thousand at the last glacial maximum. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailOptimization of biosurfactant lipopeptide production from Bacillus subtilis S499 by Plackett-Burman design
Jacques, Philippe ULg; Hbid, C.; Destain, Jacqueline ULg et al

in Applied Biochemistry and Biotechnology (1999), 77-9

Bacillus subtilis S499 is well-known for its ability to produce two families of surfactant lipopeptides: Iturin A and Surfactin S1. Fermentation optimization for this strain was performed to amplify the ... [more ▼]

Bacillus subtilis S499 is well-known for its ability to produce two families of surfactant lipopeptides: Iturin A and Surfactin S1. Fermentation optimization for this strain was performed to amplify the surfactant production. Ten active variables were analyzed by two successive Plackett-Burman designs, consisting respectively of 12 and 16 experiments to give an optimized medium. The amount of biosurfactant lipopeptides in the supernatant of a culture carried out in this optimized medium was about five times higher than that obtained in nonoptimized rich medium. The analysis of the surfactant molecules produced in such optimized conditions has revealed the presence of a third family of lipopeptides: the fengycins. The time-dependent production of these three families of molecules in bioreactors showed that surfactin S1 is produced during the exponential phase and iturin A and fengycins during the stationary phase. [less ▲]

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See detailMedical aspects of obesity.
Scheen, André ULg; Luyckx, Françoise ULg

in Acta Chirurgica Belgica (1999), 99(3), 135-9

Obesity poses a serious health hazard and its treatment is often disappointing. Major advances have been made during recent years in the understanding of body weight regulation, with the discovery of ... [more ▼]

Obesity poses a serious health hazard and its treatment is often disappointing. Major advances have been made during recent years in the understanding of body weight regulation, with the discovery of leptin, a protein produced by adipocytes and acting on the central nervous system to reduce food intake, and that of beta-3 adrenergic receptors and uncoupling proteins which contribute to stimulate energy expenditure. Numerous metabolic complications are associated with abdominal obesity and most of them, such as diabetes mellitus, dyslipidaemias and arterial hypertension, appear to be linked to insulin resistance and may be part of the socalled metabolic syndrome or syndrome X. While very-low-calorie diets are usually effective in the short-term, they cannot, in the long-term and for most patients, solve the problem of severe obesity. Pharmacological antiobesity treatment may include drugs that reduce food intake, drugs that increase energy expenditure and drugs that affect nutrient partitioning or metabolism. All of these pharmacological approaches have potential efficacy, but unfortunately serious limitations. This is also the case of mechanical means, such as intragastric balloons. Consequently, bariatric surgery may be considered as a valuable alternative therapy in well-selected patients with morbid obesity refractory to classical treatments. In conclusion, obesity is a chronic disease and should be treated as such with reasonable expectations. [less ▲]

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See detailVillers-le-Bouillet/Vaux-et-Borset: campagne de fouilles “A la Croix Marie-Jeanne”
Caspar, Jean-Paul; Delye, Emmanuel ULg; Rots, Veerle ULg et al

in Chronique de l’Archéologie Wallonne (1999), 7

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See detailThe long-term cytoskeletal rearrangement induced by rabbit enteropathogenic Escherichia coli is Esp-dependent but intimin-independent
Nougayrède, J. P.; Marchès, O.; Boury, M. et al

in Molecular Microbiology (1999), 31

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See detailNanometer scale organization of mixed surfactin/phosphatidylcholine monolayers
Deleu, Magali ULg; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Biophysical Journal (1999), 77(4), 2304-2310

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic ... [more ▼]

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). AFM topographic images revealed phase separation for mixed monolayers prepared at 0.1, 0.25, and 0.5 surfactin molar ratios. This was in agreement with the monolayer properties at the air-water interface indicating a tendency of the two compounds to form bidimensional domains in the mixed systems. The step height measured between the surfactin and the DPPC domains was 1.2 +/- 0.1 nm, pointing to a difference in molecular orientation: while DPPC had a vertical orientation, the large peptide ring of surfactin was lying on the mica surface. The N/C atom concentration ratios obtained by XPS for pure monolayers were compatible with two distinct geometric models: a random layer for surfactin and for DPPC, a layer of vertically-oriented molecules in which the polar headgroups are in contact with mica. XPS data for mixed systems were accounted for by a combination of the two pure monolayers, considering respective surface coverages that were in excellent agreement with those measured by AFM. These results illustrate the complementarity of AFM and XPS to directly probe the molecular organization of multicomponent monolayers. [less ▲]

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See detailCharacterization of YKL165c a new essential gene of the yeast Saccharomyces cerevisiae.
Delbecq, Xavier; Godrie, Thérèse ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie et de Biochimie (1999), 107

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See detailPrinciples of QoS in group communications
Mathy, Laurent ULg; Edwards, C.; Hutchison, D.

in Telecommunication Systems (1999), 11(1), 59--84

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See detailProtochlorophyllide-NADP(+) and protochlorophyllide-NADPH complexes and their regeneration after flash illumination in leaves and etioplast membranes of dark-grown wheat
Franck, Fabrice ULg; Bereza, B.; Boddi, B.

in Photosynthesis Research (1999), 59(1), 53-61

The fast (1 min) regeneration process of the photoactive Pchlide forms after a light flash was studied in etiolated wheat leaves, and this process was simulated in vitro by incubating etioplast inner ... [more ▼]

The fast (1 min) regeneration process of the photoactive Pchlide forms after a light flash was studied in etiolated wheat leaves, and this process was simulated in vitro by incubating etioplast inner membranes of wheat with excess NADPH or NADP(+). The 77 K fluorescence spectra were recorded after flash illumination, dark incubation and a subsequent flash illumination of the samples. A non-photoactive Pchlide form with an emission maximum at 650 nm was transiently detected in leaves during regeneration of a photoactive Pchlide form with an emission maximum at 654 nm. Gaussian deconvolution of fluorescence spectra of isolated membranes showed that this 650 nm form appeared in conditions of excess NADP(+), as suggested in previous studies. Additionally a Pchlide form emitting at 638.5 nm was detected in the same conditions. The analysis of the spectra of leaves at different times after a flash indicated that these two non-photoactive forms are involved as intermediates in the regeneration of photoactive Pchlide. This regeneration is in correlation with the production of the Chlide form emitting at 676 nm. The results demonstrate that, in vivo, part of the NADPH:protochlorophyllide oxidoreductase is reloading with nonphotoactive Pchlide on a fast time-scale and that the 676 nm Chlide form is the released product of the phototransformation in this process. [less ▲]

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See detailTranslocation (2;3)(p21;q26) as the sole anomaly in a case of primary myelofibrosis.
Herens, Christian ULg; Hermanne, Jean-Philippe; Tassin, Françoise ULg et al

in Cancer Genetics & Cytogenetics (1999), 110(1), 62-4

Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with ... [more ▼]

Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with the 11 other previously published myeloid-associated t(2p;3q) cases confirms that this nonrandom translocation involves a pluripotent stem cell and is associated with a poor prognosis. [less ▲]

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See detailH-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase
Damblon, Christian ULg; Prosperi, Christelle ULg; Lian, L. Y. et al

in Journal of the American Chemical Society (1999), 121(49), 11575-11576

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See detailNC100100, a new echo contrast agent for the assessment of myocardial perfusion--safety and comparison with technetium-99m sestamibi single-photon emission computed tomography in a randomized multicenter study.
Binder, T.; Assayag, P.; Baer, F. et al

in Clinical cardiology (1999), 22(4), 273-82

BACKGROUND AND HYPOTHESIS: Myocardial contrast echocardiography using second-generation agents has been proposed to study myocardial perfusion. A placebo-controlled, multicenter trial was conducted to ... [more ▼]

BACKGROUND AND HYPOTHESIS: Myocardial contrast echocardiography using second-generation agents has been proposed to study myocardial perfusion. A placebo-controlled, multicenter trial was conducted to evaluate the safety, optimal dose, and imaging mode for NC100100, a novel intravenous second-generation echo contrast agent, and to compare this technique with technetium-99m sestamibi (MIBI) single-photon emission computed tomography (SPECT). METHODS: In a placebo-controlled, multicenter trial, 203 patients with myocardial infarction > 5 days and < 1 year previously underwent rest SPECT and MCE. Fundamental and harmonic imaging modes combined with continuous and electrocardiogram-- (ECG) triggered intermittent imaging were used. Six dose groups (0.030, 0.100, and 0.300 microliter particles/kg body weight for fundamental imaging; and 0.006, 0.030, and 0.150 microliter particles/kg body weight for harmonic imaging) were tested. A saline group was also included. Safety was followed for 72 h after contrast injection. Myocardial perfusion by MCE was compared with myocardial rest perfusion imaging using MIBI as a tracer. RESULTS: NC100100 was well tolerated. No serious adverse events or deaths occurred. No clinically relevant changes in vital signs, laboratory parameters, and ECG recordings were noted. There was no significant difference between adverse events in the NC100100 (25.7%) and in the placebo group (17.9%, p = 0.3). Intermittent harmonic imaging using the intermediate dose was superior to all other modalities, allowing the assessment of perfusion in 76% of all segments. Eighty segments (96%) with normal perfusion by SPECT imaging also showed myocardial perfusion with MCE. However, a substantial percentage of segments (61-80%) with perfusion defects by SPECT imaging also showed opacification by MCE. This resulted in an overall agreement of 66-81% and a high specificity (80-96%), but in low sensitivity (20-39%) of MCE for the detection of perfusion defects. CONCLUSION: NC100100 is safe in patients with myocardial infarction. Intermittent harmonic imaging with a dose of 0.03 microliter particles/kg body weight can be proposed as the best imaging protocol. Myocardial contrast echocardiography with NC 100100 provides perfusion information in approximately 76% of segments and results in myocardial opacification in the vast majority of segments with normal perfusion as assessed by SPECT. Although the discrepancies between MCE and SPECT with regard to the definition of perfusion defects requires further investigation, MCE with NC 100100 is a promising technique for the noninvasive assessment of myocardial perfusion. [less ▲]

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See detailL'etude clinique du mois. L'etude CAPPP: "The Captopril Prevention Project".
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(3), 197-9

The Captopril Prevention Project (CAPPP) was a prospective, randomized, open trial which aimed at comparing the prevention by captopril (n = 5492) or by a conventional treatment (n = 5493; diuretics or ... [more ▼]

The Captopril Prevention Project (CAPPP) was a prospective, randomized, open trial which aimed at comparing the prevention by captopril (n = 5492) or by a conventional treatment (n = 5493; diuretics or beta-blockers) of cardiovascular morbidity and mortality in patients with hypertension (diastolic blood pressure > 100 mmHg). After a mean follow-up of 6.1 years, the results regarding the primary endpoint and most secondary endpoints were not significantly different between the two therapeutic modalities. The only differences (perhaps due to a randomisation bias) were a slightly higher incidence of stroke, but a lower risk of diabetes mellitus, in the captopril group than in the group receiving conventional treatment. In conclusion, the CAPPP study demonstrates, for the first time, that captopril, an angiotensin-converting-enzyme inhibitor, is as effective as conventional treatment with diuretics or beta-blockers, two drugs whose efficacy has already been demonstrated when compared to placebo, in the prevention of cardiovascular morbidity and mortality in hypertensive patients. [less ▲]

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See detailWestward propagation of the North Anatolian fault into the northern Aegean: Timing and kinematics
Armijo, R.; Meyer, B.; Hubert, Aurelia ULg et al

in Geology (1999), 27

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the ... [more ▼]

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the finite displacement after, the passage of the propagating tip of the fault. The accuracy of the observations is due to interplay between deformation and the sea-level changes in the Mediterranean (the well-known Messinian regression followed by the Pliocene transgres- sion). The long-term kinematics around the Sea of Marmara pull-apart (total displacement of about 85 km over the past 5 m.y.) is similar to the present-day kinematics deduced from space geodesy. At a larger scale, westward propagation of the North Anatolian fault over nearly 2000 km in the past 10 m.y. appears to be associated with strain recovery, suggesting that the continental lithosphere retains long-term elasticity. [less ▲]

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See detailDe Luikse regio: een gebied in verandering
Merenne-Schoumaker, Bernadette ULg

in De Aardrijkskunde (1999), (4), 3-44

Excusion booklet-guide in the Region of Liege with the aim to pin the principal changes occurred recently in the economy and within Liege spaces. Five parts : - a introduction presenting the program of ... [more ▼]

Excusion booklet-guide in the Region of Liege with the aim to pin the principal changes occurred recently in the economy and within Liege spaces. Five parts : - a introduction presenting the program of the excursion, - a short analysis of the town, - a recent assessment of the district econmy, - a general statistical file and - eleven thematic files devoted to eleven major points of the excusion [less ▲]

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See detailEndogenous auxin and cytokinin levels in shoots of a nonrooting tobacco mutant
Faivre-Rampant, O.; Kevers, Claire ULg; Gaspar, Th

in Bulletin de la Societe Royale des Sciences de Liege (1999), 68(5-6), 318

[No abstract available]

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See detailCurrent perspectives on developmental dysphasias
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Journal of Neurolinguistics (1999), 12(3-4), 181-212

This paper documents the major difficulties observed in the oral language development of individuals with mental retardation of genetic origin. The extent of inter- and within-syndrome variability is ... [more ▼]

This paper documents the major difficulties observed in the oral language development of individuals with mental retardation of genetic origin. The extent of inter- and within-syndrome variability is evaluated. More specifically, a comparative analysis of typical language phenotypes in several genetic syndromes is attempted and the possible brain underpinnings of the observed differences are envisaged. Recent cases of favorable language development in individuals with mental retardation are summarized and explanatory variables are discussed. [less ▲]

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See detailMass-Transfer Enhancement in Single-Drop Extraction Experiments
Henschke, Martin; Pfennig, Andreas ULg

in AIChE Journal (1999), 45(10), 2079-2086

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See detailEncurvadura Lateral de Vigas Metalicas Sujeitas à Acçao do Fogo - Estudo Numerico e Experimental
Vila Real, Paulo; Piloto, Paulo; Franssen, Jean-Marc ULg et al

in Mecânica Experimental (1999), 4

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See detailGEQUAC, an excess Gibbs energy model describing associating and non-associating liquid mixtures by a new model concept for functional groups
Egner, Katja; Gaube, Johann; Pfennig, Andreas ULg

in Fluid Phase Equilibria (1999), 158(381-389),

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See detailLes etudes cliniques controlees, support incontournable de la medecine basee sur l'evidence.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1999), 54(1), 1

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See detailGroup Contribution Method GTASQUAC
Lacmann, R; Schäfer, B; Brennecke, D et al

in Physical Chemistry Chemical Physics [=PCCP] (1999), 1

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See detailModelling of the liquid distribution in a trickle flow packed column based upon X-ray tomography images
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Chemical Engineering Communications (1999), 175

X-ray tomography is used to characterise the liquid distribution in a 0.6 meter diameter and 2 meter height column filled with gas-liquid absorption polypropylene packing elements (Cascade Mini-Ring 1A ... [more ▼]

X-ray tomography is used to characterise the liquid distribution in a 0.6 meter diameter and 2 meter height column filled with gas-liquid absorption polypropylene packing elements (Cascade Mini-Ring 1A, Glitsch Benelux). The liquid holdup distribution is determined for liquid flowrates ranging from 1000 l/h to 6000 l/h, that correspond to superficial velocities ranging from 10(-3) to 6 10(-3) m/s, in several cross sections situated at different heights in the packed column. A characteristic length, corresponding to the smallest scale beyond which the packing properties may be supposed statistically homogenous and isotropic, as determined by Means of the autocorrelation function method applied to the images of the solid distribution. Both local and global liquid holdup measurements are satisfactorily modelled by means of a partial wetting model based on a probabilistic approach. [less ▲]

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See detailFlora and vegetation of Turtell V, Turtell Islands group (Queensland, Australia).
De Sloover, Jacques; Dufrêne, Marc ULg

in Bulletin du Jardin Botanique National de Belgique = Bulletin van de Nationale Plantentuin van België (1999), 67

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See detailEvaluation du système de financement des journées hospitalières en fonction des pathologies
Fecher-Bourgeois, Fabienne ULg; Gillet, Pierre ULg

in Bulletin des Résumés d'Informations Hospitalières / Ministère des affaires sociales, de la santé publique et de l'environnement (1999), 16(Janvier/février/mars 1999),

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See detailCardiac autonomic dysfunction in diabetic children.
Massin, M. M.; Derkenne, B.; Tallsund, M. et al

in Diabetes care (1999), 22(11), 1845-50

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can ... [more ▼]

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can be used to detect subclinical autonomic neuropathy in diabetic children. RESEARCH DESIGN AND METHODS: We examined five time domain and three frequency domain HRV indices determined from 24-h Holter recordings in 73 diabetic children and adolescents aged 3-18 years (mean 12.1 years) with a mean duration of diabetes of 55 months. The measures were compared with normal ranges. Z scores were established for each parameter and were compared with classic risk factors of other diabetic complications. RESULTS: Most HRV indices were significantly depressed in children aged > or = 11 years, and the levels of HRV abnormalities were significantly correlated with long-term metabolic control (mean GHb for 4 years) in that age-group. In younger patients, HRV indices were within the normal range and were not correlated with the level of metabolic control. Illness duration and microalbuminuria but not short-term metabolic control (most recent GHb) were also independently predictive of HRV abnormalities. CONCLUSIONS: These results suggest that early puberty is a critical period for the development of diabetic cardiac autonomic dysfunction. Therefore, all type 1 diabetic patients should be screened for this complication by HRV analysis beginning at the first stage of puberty regardless of illness duration, microalbuminuria, and level of metabolic control. [less ▲]

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See detailIonization potentials of atoms and ions from lithium to tin (Z = 50)
Biémont, Emile ULg; Frémat, Y.; Quinet, Pascal ULg

in At. Data Nucl. Data Tables (1999), 71

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See detailInterfacial and emulsifying properties of lipopeptides from Bacillus subtilis
Deleu, Magali ULg; Razafindralambo, Hary ULg; Popineau, Y. et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (1999), 152(1-2), 3-10

The fundamental surface-active properties at the oil/water interface and emulsifying properties of surfactin, iturin A and fengycin, lipopeptides from Bacillus subtilis, were investigated. All ... [more ▼]

The fundamental surface-active properties at the oil/water interface and emulsifying properties of surfactin, iturin A and fengycin, lipopeptides from Bacillus subtilis, were investigated. All lipopeptides reduce rapidly the dynamic interfacial tension. Among lipopeptide families, surfactin is the most effective in terms of fundamental dynamic and equilibrium interfacial properties. Lipopeptides present intermediate properties in comparison with sodium dodecyl sulfate and beta-lactoglobulin concerning the stabilizing effect towards creaming-flocculation and the resistance to coalescence. Among lipopeptides, iturin A seems to show the best resistance to creaming-flocculation whereas fengycin exhibits the highest resistance to coalescence properties. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailChemical changes and influences of rapeseed antinutritional factors on lamb physiology and performance - 2. Plasma substances and activity of the thyroid
Mandiki, S. N. M.; Mabon, N.; Derycke, G. et al

in Animal Feed Science & Technology (1999), 81(1-2), 93-103

In order to study the effects of a high level of rapeseed meal in the diet on endocrine function and thyroid activity, sixty six Texel, Suffolk or crossbred lambs allocated to three groups were fed ad ... [more ▼]

In order to study the effects of a high level of rapeseed meal in the diet on endocrine function and thyroid activity, sixty six Texel, Suffolk or crossbred lambs allocated to three groups were fed ad libitum with concentrates containing 0% (Control) or 25% of rapeseed meal obtained with either Samourai (Samourai) or Honk (Honk) rapeseed varieties. Lambs were weaned at 88 +/- 8 days of age and 24 +/- 5 kg of live weight and were slaughtered when their fattening state was estimated to be satisfactory. Blood samples were taken fortnightly for the determinations of hormones, glucose and transaminases (GOT and GPT). To evaluate the capacity of hormone production, the thyroid glands were collected at slaughter and the in-vitro release of thyroid hormones was recorded. The plasma concentrations in triiodothyronine (T-3) and thyroxine (T-4) decreased (P <0.05) with the age of lambs and were lower (P <0.05) in the Samourai and Honk groups than in the Control. Moreover, the capacity of T-3 and T-4 production by the thyroid gland shown by the in-vitro T-3 and T-4 accumulation in the thyroid tissues was higher (P <0.05) in the Control than in the two rapeseed groups. In contrast, the concentrate with rapeseed meal had no effect on the plasma concentrations in GH, cortisol and insulin nor on other substances (glucose, GOT and GPT). These results indicate that the ingestion of rapeseed meal induces a low functional disorder of the thyroid without affecting the animal performance of lambs, as we reported previously. This is because the thyroid hormones do not appear to play a major role in the processes of growth and fattening, these having been successively taken under the control on priority by GH and insulin. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailConversion of green note aldehydes into alcohols by yeast alcohol dehydrogenase
Fauconnier, Marie-Laure ULg; Mpambara, A.; Delcarte, Jérôme et al

in Biotechnology Letters (1999), 21(7), 629-633

‘Green note’ aldehydes were successfully reduced into their corresponding alcohol by commercial yeast alcohol dehydrogenase. Among different yeasts tested for their ability to convert (Z)-3-hexenal into ... [more ▼]

‘Green note’ aldehydes were successfully reduced into their corresponding alcohol by commercial yeast alcohol dehydrogenase. Among different yeasts tested for their ability to convert (Z)-3-hexenal into (Z)-3-hexenol, Pichia anomala gave the best results. Conversion yields higher than 90% were also obtained by directly conducting the reaction in the medium where (Z)-3-hexenal is produced by the action of lipoxygenase and hydroperoxide lyase on <br />linolenic acid. [less ▲]

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See detail"Observations sur les observations ou de la sanction du délai prévu pour adresser des observations au juge de la mise en état"
Moreau, Pierre ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederechters (1999), (8, 9, 10), 357-361

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See detailUnimolecular reaction dynamics from kinetic energy release distributions. III. A comparative study of the halogenobenzene cations
Urbain, P.; Leyh, Bernard ULg; Remacle, Françoise ULg et al

in Journal of Chemical Physics (1999), 110(2-12), 2911-2921

The translational kinetic energy release distribution (KERD) in the halogen loss reaction of the chloro-, bromo-, and iodobenzene cations has been experimentally determined in the microsecond time scale ... [more ▼]

The translational kinetic energy release distribution (KERD) in the halogen loss reaction of the chloro-, bromo-, and iodobenzene cations has been experimentally determined in the microsecond time scale and theoretically analyzed by the maximum entropy method. The KERD is constrained by the square root of the translational energy, i.e., by the momentum gap law. This can be understood in terms of quantum-mechanical resonances controlled by a matrix element involving a localized bound state and a rapidly oscillating continuum wave function, as in the case of a vibrational predissociation process. The energy partitioning between the reaction coordinate and the set of the remaining coordinates is nearly statistical, but not quite: less translational energy is channeled into the reaction coordinate than the statistical estimate. The measured entropy deficiency leads to values of the order of 80% for the fraction of phase space sampled by the pair of fragments with respect to the statistical value. In the case of the dissociation of the chlorobenzene ion, it is necessary to take into account a second process which corresponds to the formation of the chlorine atom in the excited electronic state 2P 1/2 in addition to the ground state 2/ 1/2. The observations are compatible with the presence of a small barrier (of the order of 0.12 eV) along the reaction path connecting the D̃ 2A 1 state of C 6H 5Cl + to the Cl( 2P 1/2) + C 6H 5 +(X̃ 1A 1) asymptote. © 1999 American Institute of Physics. [less ▲]

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See detailCorticosensitivity in whole blood cell cultures in Crohn's disease and healthy subjects
Franchimont, Denis; Louis, Edouard ULg; Geenen, Vincent ULg et al

in Digestive Diseases & Sciences (1999), 44

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See detailShelley in travestie: De vertaalstrijd om 'Alastor'
Steyaert, Kris ULg

in Filter: Tijdschrift over Vertalen (1999), 6(3), 28-36

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See detailEcrire en deux langues. Remarques sur le mixage des écritures grecque et latine d'après les papyrus bilingues d'auteurs classiques
Rochette, Bruno ULg

in Scriptorium (1999), 53(2), 325-334

Quatre fragments des « Catilinaires » de Cicéron et dix de Virgile (un des « Georgiques » et neuf de l'« Énéide »), datant des 4e-6e s., nous renseignent sur la place et l'enseignement du latin dans l ... [more ▼]

Quatre fragments des « Catilinaires » de Cicéron et dix de Virgile (un des « Georgiques » et neuf de l'« Énéide »), datant des 4e-6e s., nous renseignent sur la place et l'enseignement du latin dans l'univers égyptien hellénophone. L'étude comparée des écritures grecque et latine (onciale, semi-onciale et cursive) semble confirmer l'hypothèse d'un procédé d'écriture propre aux textes bilingues, imaginé par les scribes pour favoriser l'apprentissage du latin. La familiarité des traducteurs et des utilisateurs de ces textes avec le vocabulaire juridique est également patente, mais le phénomène des éditions bilingues touche des milieux variés et devient ainsi une première étape vers la formation d'une écriture latine largement redevable au grec, dans un monde où le bilinguisme est la règle. [less ▲]

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See detailDiagnostiquer les Troubles Spécifiques de l'Apprentissage
Garcet, Serge ULg

in Revue Scientifique de l'AIGS, (1999), 2

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See detailInventaire des plantes aquatiques du lit majeur de la Moselle, France, Luxembourg et Allemagne
Klein, J. P.; Vanderpoorten, Alain ULg

in Willemetia (1999), 3(18), 1-6

The inventory of the aquatic flora found in the Moselle river indicates the state of botanical knowledge at the end of 1999. It includes a total of 48 aquatic macrophytes and 20 bryophytes. Among the ... [more ▼]

The inventory of the aquatic flora found in the Moselle river indicates the state of botanical knowledge at the end of 1999. It includes a total of 48 aquatic macrophytes and 20 bryophytes. Among the recorded species two are protected in France (Luronium natans, Pilularia globulifera) and two in the Lorraine region (Potamogeton gramineus, Vallisneria spiralis). [less ▲]

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See detailLa petite musique d'Isabelle Stengers. Entretien avec une philosophe de l'invention
Havelange, Carl ULg; Despret, Vinciane ULg

in Le Carnet et les Instants (1999), juillet-décembre 1999(16 (paru en 2001)), 10-16

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See detailPLENA and FARINELLI: redundancy and regulatory interactions between two Antirrhinum MADS-box factors controlling flower development.
Davies, B.; Motte, Patrick ULg; Keck, E. et al

in EMBO Journal (1999), 18(14), 4023-34

We report the discovery of an Antirrhinum MADS-box gene, FARINELLI (FAR), and the isolation of far mutants by a reverse genetic screen. Despite striking similarities between FAR and the class C MADS-box ... [more ▼]

We report the discovery of an Antirrhinum MADS-box gene, FARINELLI (FAR), and the isolation of far mutants by a reverse genetic screen. Despite striking similarities between FAR and the class C MADS-box gene PLENA (PLE), the phenotypes of their respective mutants are dramatically different. Unlike ple mutants, which show homeotic conversion of reproductive organs to perianth organs and a loss of floral determinacy, far mutants have normal flowers which are partially male-sterile. Expression studies of PLE and FAR, in wild-type and mutant backgrounds, show complex interactions between the two genes. Double mutant analysis reveals an unexpected, redundant negative control over the B-function MADS-box genes. This feature of the two Antirrhinum C-function-like genes is markedly different from the control of the inner boundary of the B-function expression domain in Arabidopsis, and we propose and discuss a model to account for these differences. The difference in phenotypes of mutants in two highly related genes illustrates the importance of the position within the regulatory network in determining gene function. [less ▲]

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See detailCalcul et conception économique des assemblages de profilés reconstitués soudés
Braham, M.; Cerfontaine, F.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1999), (N°1), 5-24

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See detailLes biotechnologies vegetales appropriees dans le contexte du dialogue Nord-Sud.
Lepoivre, Philippe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(1),

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See detailReproduction of Lesions and Clinical Signs with a Cnf2-Producing Escherichia Coli in Neonatal Calves
Van Bost, S.; Mainil, Jacques ULg

in Advances in Experimental Medicine and Biology (1999), 473

CNF2-producing necrotoxigenic E. coli (NTEC2) are associated with diarrhoea and septicaemia in calves. We orally inoculated neonatal calves with a NTEC2 strain in order to reproduce clinical signs and ... [more ▼]

CNF2-producing necrotoxigenic E. coli (NTEC2) are associated with diarrhoea and septicaemia in calves. We orally inoculated neonatal calves with a NTEC2 strain in order to reproduce clinical signs and lesions. We observed diarrhoea in each inoculated calf, bacteraemia (80%), the presence of CNF2+ bacteria in the lungs (80%) and in the liver (20%). The observed lesions were inflammation of the entire gut, hypertrophy of the mesenteric lymph nodes and hepatisation of the lungs. We were unable to detect characteristic lesions that are classical signs of septicaemia. [less ▲]

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See detailParamètres hydrologiques et physicochimiques de sources de haute Belgique : ébauche d'une typologie régionale
Petit, François ULg; Araujo, J.; Brassine, B. et al

in Bulletin de la Société Géographique de Liège (1999)

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See detailUnunited medial epicondyle of the humerus in a dog : a case report
Snaps, Frédéric ULg; Balligand, Marc ULg; Saunders, J. et al

in Canine Practice (1999), 24(6), 7-10

A Labrador crossbreed female dog was presented for a right forelimb lameness of 4.5 years' duration. The severity of the symptoms had suddenly increased 8 months earlier, after a trauma. Surgical ... [more ▼]

A Labrador crossbreed female dog was presented for a right forelimb lameness of 4.5 years' duration. The severity of the symptoms had suddenly increased 8 months earlier, after a trauma. Surgical exploration did not reveal calcification either in the joint capsule or in the flexor tendons. The fragment was intraarticular. No evidence of bone repair was noticed at surgery which confirmed imaging findings. The histologic findings were very much like those observed with chronic fragmented coronoid process. Finally, the lameness, although suddenly exacerbated by a trauma, was already present. All these facts led to a final diagnosis of a true "ununited medial humeral epicondyle", a term introduced to describe the lack of fusion of the caudal part of the humeral medial epicondyle [less ▲]

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See detailAnalyse du comportement des structures métalliques en cas d'incendie
Franssen, Jean-Marc ULg; Dhima, Dhionis

in Construction Métallique (1999), 3

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See detailEarly prepubertal ontogeny of pulsatile gonadotropin-releasing hormone (GnRH) secretion: I. Inhibitory autofeedback control through prolyl endopeptidase degradation of GnRH.
Yamanaka, C.; LEBRETHON, Marie-Christine ULg; Vandersmissen, E. et al

in Endocrinology (1999), 140(10), 4609-15

GnRH[1-5], a subproduct resulting from degradation of GnRH by prolyl endopeptidase (PEP) and endopeptidase 24.15 (EP24.15) was known to account for an inhibitory autofeedback of GnRH secretion through an ... [more ▼]

GnRH[1-5], a subproduct resulting from degradation of GnRH by prolyl endopeptidase (PEP) and endopeptidase 24.15 (EP24.15) was known to account for an inhibitory autofeedback of GnRH secretion through an effect at the N-methyl-D-aspartate (NMDA) receptors. This study aimed at determining the possible role of such a mechanism in the early developmental changes in frequency of pulsatile GnRH secretion. Using retrochiasmatic explants from fetal male rats (day 20-21 of gestation), no GnRH pulses could be observed in vitro, whereas pulses occurred at a mean interval of 86 min from the day of birth onwards. This interval decreased steadily until day 25 (39 min), during the period preceding the onset of puberty. Based on GnRH[1-10] or GnRH[1-9] degradation and GnRH[1-5] generation after incubation with hypothalamic extracts, EP24.15 activity did not change with age, whereas PEP activity was maximal at days 5-10 and decreased subsequently until day 50. These changes were consistent with the ontogenetic variations in PEP messenger RNAs (mRNAs) quantitated using RT-PCR. Using fetal explants, the NMDA-evoked release of GnRH was potentiated in a dose-dependent manner by bacitracin, a competitive PEP inhibitor and the desensitization to the NMDA effect was prevented using 2 mM of bacitracin. At day 5, a higher bacitracin concentration of 20 mM was required for a similar effect. Pulsatile GnRH secretion from fetal explants was not caused to occur using bacitracin or Fmoc-Prolyl-Pyrrolidine-2-nitrile (Fmoc-Pro-PyrrCN), a noncompetitive PEP inhibitor. At postnatal days 5 and 15, a significant acceleration of pulsatility was obtained using 1 microM of Fmoc-Pro-PyrrCN or 2 mM of bacitracin. At 25 and 50 days, a lower bacitracin concentration of 20 microM was effective as well in increasing the frequency of GnRH pulsatility. We conclude that the GnRH inhibitory autofeedback resulting from degradation of the peptide is operational in the fetal hypothalamus but does not explain the absence of pulsatile GnRH secretion at that early age. After birth, PEP activity is high and may account for the low frequency of pulsatility. The potency of that effect decreases before the onset of puberty and may contribute to the acceleration of GnRH pulsatility. [less ▲]

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See detailApplication of Miller's theorem to the stability analysis of numerical schemes; some useful tools for rapid inspection of discretisations in ocean modelling
Beckers, Jean-Marie ULg

in Ocean Modelling (1999), 1

An old theorem about the roots of a polynomial is resurfaced and examined, focusing on the practical question of determining stability criteria for numerical schemes. Is is demonstrated that the theorem ... [more ▼]

An old theorem about the roots of a polynomial is resurfaced and examined, focusing on the practical question of determining stability criteria for numerical schemes. Is is demonstrated that the theorem can be useful both for analytical studies of the stability limits, as well as numerical searches for stability regions. It is particularly important that when deciding whether the scheme is stable or not, it is not necessary to search for the roots of the polynomial. Indeed, such a decision may be reached through a finite and small number of arithmetic operations and verifications of inequalities. In addition to the analysis of the theorem, some practical conditions for polynomial of different orders are presented, as well as some useful tips on how simply necessary or sufficient stability conditions can be obtained. [less ▲]

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